I had had great hopes in Australia. Like many who came before or around the time when I came, I regarded Australia as a land of opportunity. However, that opportunity seemed to exist for Australians and people from other countries of the British Commonwealth and not the likes of me. Even though I had sworn my allegiance, Australians saw in me an un-Australian.-Ouyang Yu (2002)The Eastern Slope Chronicle is a novel about migration, focusing on dao Zhuang, a male Chinese migrant who seems unable to belong anywhere. it is also about the protagonist's self-discovery and discovery of his home and host countries. this paper examines the impact of migration on gender norms and how tensions between different gender norms, particularly models for masculinity, play out in the novel. While previous criticism has addressed The Eastern Slope Chronicle from the perspective of cultural, ethnic, or national identity,1 issues surrounding the impact of migration on gender identity remain virtually unexplored.The Eastern Slope Chronicle is a semi-autobiographical narrative in that author ouyang Yu and his character dao Zhuang have similar trajectories. ouyang is one of the numerous migrants from mainland China who have arrived in Australia since the mid-1980s. He arrived in 1991 to undertake a phd on the representation of Chinese in Australian fiction at Melbourne's La trobe University. A prolific writer in both Chinese and english, he is best known for his poetry collections Moon Over Melbourne and Songs of the Last Chinese Poet. The Eastern Slope Chronicle, his first novel, traces a life similar but not identical to his own, teasing the reader by offering not one but three alter egos for the author: dao Zhuang; Wu Liao, a character in a novel written by dao; and Wang Fu Fei, or Warne, dao's friend, who is also a writer. With the tiananmen square events of 1989 as the historical backdrop, The Eastern Slope Chronicle focuses on dao's multiple migrations between a fast-changing China and a multicultural Australia. Coming from "a family of scholars" (ouyang, Eastern Slope 105), dao completed a Bachelor's degree in english and a graduation certificate from a "postgraduate Class" in China, and taught english at Red Cliff University before traveling to Australia to pursue postgraduate studies. He has a master's degree in Chinese from an Australian university, and is a phd candidate in Cross-Cultural studies. dao's educational credentials establish him as what Kam Louie identifies as a wen man or a zhishi fenzi (intellectual) in the Chinese cultural discourse. in Theorising Chinese Masculinity: Society and Gender in China, Louie presents Chinese masculinity as a wen-wu dyad (roughly equivalent to brain-brawn). According to Louie, wen refers to "those genteel, refined qualities that were associated with literary and artistic pursuits of the classical scholars," and wu generally means "physical strength and military prowess" (14). to make the wen-wu dichotomy better understood by Western readers, he renders it as "cultural attainment-martial valour" (4). An ideal man is expected to possess either wen or wu, and a scholar is regarded as no less masculine than a soldier. A man who has both superb wen and superb wu qualities is believed to stand above other men who have only one of the two attributes. such a man is likely to become a supreme leader. Wen is given precedence over wu, even though both are indispensable components of Chinese masculinity. education in its wen sense is equated with power, so a well-educated man of wen feels that he is entitled to "a leadership role in the moral and social dimensions as well" (5).Chinese wen men or intellectuals in modern times are modeled on the Confucian scholars in imperial times. in imperial China, because the ruling class chose its bureaucrats from Confucian scholars, scholars were ranked above peasants, craftsmen, and businessmen. in the long sweep of Chinese history, wen masculinity, which values educational credentials and cultural attainments, has occupied a dominant position (Louie, Theorising 17-21). …


Coconut oil in microemulsion is a better option than conventional practice since it can incorporate bioactive ingredients with a stable control release property, especially for hair care products. This work aims to develop microemulsion systems based on coconut oil with the addition of Tween 20, Tween 40, and Tween 80 as non-ionic surfactants (S), and propylene glycol as a co-surfactant (CoS). The determination of microemulsion regions in the ternary phase diagram was carried out by water titration method and the properties of the microemulsion were analysed. Based on the results, the microemulsion system of coconut oil with Tween 80 produced the largest microemulsion region compared to Tween 40 and Tween 20. Microemulsion systems of coconut oil/Tween 80 with the addition of propylene glycol with the ratio of S/CoS at Km = 3:1, 2:1, and 1:1 resulted in a decrement of microemulsion regions compared to using merely Tween 80. The microemulsion system of coconut oil/Tween 80/water at the ratio of oil: surfactant = 1:9 was chosen for further characterisations. Viscosity and electrical conductivity studies showed that the microemulsion system was water-in-oil (w/o) type as there was no phase transition to bicontinuous (BC) or oil-in-water (o/w) type due to low percentage of water content. Stability studies showed that the microemulsion system remained clear and stable at 25 and 40°C upon one-month storage except at 4°C where the system became cloudy and turbid. For particle size analysis, the microemulsion system possessed particle size less than 100 nm.


TP53 is the most frequently mutated gene in human breast cancers and its mutations have been found in all breast cancer subtypes (e.g., luminal, basal-like, claudin-low). Genome-sequencing studies predict that TP53 mutation is an early event in breast cancer development. However, how p53-deficiency contributes to breast cancer initiation, leading to development of different subtypes of breast cancer, remains largely elusive. To address this, we developed a novel approach to trace development of breast cancer from luminal mammary epithelial cells (MECs), which may represent cells of origin for most breast cancers. Our approach is based on induced loss of p53 in luminal MECs at the level of single cells, via intraductal injection of Cre-expressing adenovirus under the control of the pan-luminal Keratin 8 promoter (Ad-K8-Cre). This genetic approach permits evolution of single mutant luminal MECs in their native habitat through interaction with the microenvironment (e.g., neighboring p53-wild type MECs, stromal cells, immune cells), and allows us to dissect contributions from genetic, epigenetic, and environmental factors to breast tumorigenesis. Lineage and clonal analyses revealed that induced loss of p53 alone in luminal MECs triggered their clonal expansion without affecting their original luminal identity, leading to formation of a p53-deficient luminal premalignant field. Molecular analysis of luminal MECs in this premalignant field revealed potential involvement of environmental factors (e.g., cyclic ovarian hormones, immune cells in the mammary gland microenvironment) in its formation. Claudin-low mammary tumors eventually emerged from this p53-deficient luminal premalignant field with 100% penetrance, apparently due to acquisition of spontaneous, recurrent mutations in p53-deficient MECs. These data support that p53-deficiency alone does not affect the fate of luminal MECs directly, but it facilitates development of mammary tumors with loss of the luminal identity after a long latency. As deficiencies of both p53 and BRCA1 in luminal MECs predispose them to development of basal-like breast cancer (rather than claudin-low cancer), we studied whether induced loss of BRCA1 in p53-deficient luminal MECs would lead to their cell fate alteration. In fact, when we induced loss of both p53 and BRCA1 in luminal MECs, we observed luminal-to-basal cell fate alteration only after a short latency. Together, our data suggest that loss of p53 in single luminal MECs leads to their clonal dominance over wild-type neighbors without directly impairing their luminal fate; it is the cooperating oncogenic events (e.g., loss of BRCA1, or acquisition of recurrent secondary mutations) that drive development of breast cancer from p53-deficient luminal cells toward different subtypes. Our results also predict that loss of p53 in luminal MECs of BRCA1 mutation carriers would not only lead to their clonal dominance, but also cause luminal-to-basal change within the mutant clones (as an early event), and ultimately development of basal-like breast cancer from these aberrant clones. This abstract is also being presented as Poster A35. Citation Format: Dongxi Xiang, Luwei Tao, Zhe Li. Elucidating mechanisms of p53-deficient breast cancer development via lineage tracing and clonal analysis [abstract]. In: Proceedings of the AACR Special Conference: Advances in Modeling Cancer in Mice: Technology, Biology, and Beyond; 2017 Sep 24-27; Orlando, Florida. Philadelphia (PA): AACR; Cancer Res 2018;78(10 Suppl):Abstract nr PR07.


Optofluidics is an intigration of microfluidics and optics based on the principles of natural fluid. It was applied and developed in various technologies, for instance, to combine the characteristics of microfluids and optics working together to be lab on a chip. This article explained the use of optofluidics which consisting of fluids and solids to develop the new innovation and modern technology. With the dissimilar properties of fluids and solids, optofluidics devices, thus, had been designed. Optofluidics was divided into three main groups: fluids in solids, fluids in fluids, and solids in fluids. Nowaday, optofluidics is applied in various ways, such as, medicine, biomedical engineering, biotechnology and sensors.


have not undergone appreciable change induced by failure to replace the bottle cap tightly within a few seconds of opening it. This latter precaution becomes extremely important if room conditions are hot and/or humid. Our concern with the procedure is that it may not be satisfactory for individuals who are not as conscientious as Mr. Bernstein. Ames Division believes that the user should recognize that good laboratory or home practice is necessary to achieve best results with the total Dextro System. The home user must recognize that since the meticulous attention to detail practiced by Mr. Bernstein is often difficult to achieve, we cannot officially recommend the procedure that he has advocated.


Objective To examine the effect of anting-anting (Acalypha indica Linn) extract with malondialdehyde levels of mice Balb/C induced streptozotocin.
Methode This study was a laboratory experimental post test only control group design. Diabetes was induced by intraperitoneal streptozotocin doses of 65mg/kg body weight dissolved in 0,02 M citrate saline buffer. The subjects used were 32 male mice divided into 4 groups (1) Non-diabetic control group; (2) Diabetic group; (3) Treated-diabetic group with metformin doses of 1,3 mg/mice/day and (4) Treated-diabetic group with anting-anting extract dose 1000mg/kg body weight/day.
Result MDA levels of non-diabetic control group 0,211±0,145µmol/L, diabetic group 0,363±0,208µmol/L, treated-diabetic group with metformin 0,389±0,187µmol/L and treated-diabetic group with anting-anting extract 0,309±0,145µmol/L.
Conclusion The experiment result showed that anting-anting (Acalypha indica Linn) extract at dose 1000mg/kg body-weight/day can reduce the MDA levels in Balb/C mice induced streptozotocin but not statistically significan. (p=0,538).


Kohut was instrumental in shifting our attention from the removal of individual defenses in the service of making the unconscious conscious to emphasizing the importance of empathically understanding the healthy, self-protective usefulness of defenses, both developmentally and during the therapeutic process. Despite this pivotal change in reactive tone toward defenses, there have been few experiences near attempts to describe how we help patients to modify characterological defenses that interfere with the healing process. In this article, I suggest that one of the most important but unrecognized ways we work through these resistances is by facilitating a shift in the patient from the need for self-protective defensiveness to a felt relational protectiveness. Verbatim clinical examples illustrate a protective attitude and explain how relational protectiveness is actualized when dealing with characterological defenses.


Discussions of urban representation have been hampered by a persistent contrast between the view from above and the view from street level, or between the urban planner's panoptic gaze and the flâneur's fleeting glance. This article challenges such contrasts by identifying a third way of representing a city, that of moving block-by-block along the length of its main thoroughfare. It traces the emergence of what it calls the "longitudinal view" back to antebellum New York, when tour guides and urban sketches promoted the "walk up Broadway" as a means to encompass the social and functional diversity of the expanding metropolis, and when visual genres such as the moving panorama and the pictorial directory offered a virtual simulation of that journey—one that echoed the perpendicular perspective of an omnibus passenger. It concludes by exploring the subsequent appropriation of the longitudinal view by artists, photographers, and filmmakers.


The importance of the early diagnosis of pulmonary tuberculosis has been fully established. The early detection of the pulmonary lesion has in the majority of instances enabled us either to cure the lesion or at least check its progress. The early diagnosis of laryngeal tuberculosis, however, is still being neglected, and too often we meet the advanced laryngeal cases, in which conservative treatment is of no avail, while radical treatment is also useless because of the existing extensive destruction of tissue. Such involvement of the larynx could often be avoided if treatment were instituted in the early infiltrative stage. Thus it could safely be said that, as in pulmonary tuberculosis, the prognosis and the successful treatment of tuberculous laryngitis depends largely on early diagnosis. In this paper, however, the discussion will not be limited to the diagnosis of the early lesion, but will include all stages and phases of laryngeal


The microbiome comprises many different types of microbes that contribute in various ways to human health, such as by aiding digestion, protecting the body against pathogens, and regulating the central nervous system. Several factors like age, diet, ethnicity, geographic location, etc., can influence the human microbiome. To understand the individual influence of a single determinant, the microbiomes of people who share similarities with respect to the other influencing factors, would need to be examined.


The effects of Ag under layer on the micro structural and magnetic properties of the FePt films were investigated. It was found that the thickness of the Ag under layer is very important factor to induce the L10 ordered FePt (001) films with high perpendicular anisotropy. The chemical ordering increased with increasing Ag layer thickness, reached its maximum at 40 nm, and then slightly decreased with further increasing Ag thickness to 50 nm. Moreover, the initial magnetization curve and the scanning electrode microscopy (SEM) results showed that the magnetization reversal mechanism of the Ag/FePt films changed from nucleation mode to pinning mode/S-W rotation with increasing the Ag thickness. The increase of the chemical ordering and the change of magnetization reversal mechanism from nucleation mode to pinning mode/S-W rotation led to the increase in out-of-plane coercivity when Ag thickness increased from 0 to 40 nm. For the sample with 50 nm Ag layer, the decrease in out-of-plane coercivity could be attributed to the decrease in the chemical ordering.


In the present study, the interaction of 5-Fluorouracil with herring sperm DNA is reported using spectroscopic and molecular modeling techniques. This binding study of 5-FU with hs-DNA is of paramount importance in understanding chemico–biological interactions for drug design, pharmacy and biochemistry without altering the original structure. The challenge of the study was to find the exact binding mode of the drug 5-Fluorouracil with hs-DNA. From the absorption studies, a hyperchromic effect was observed for the herring sperm DNA in the presence of 5-Fluorouracil and a binding constant of 6.153 × 103 M-1 for 5-Fluorouracil reveals the existence of weak interaction between the 5-Fluorouracil and herring sperm DNA. Ethidium bromide loaded herring sperm DNA showed a quenching in the fluorescence intensity after the addition of 5-Fluorouracil. The binding constants for 5-Fluorouracil stranded DNA and competitive bindings of 5-FU interacting with DNA–EB systems were examined by fluorescence spectra. The Stern–Volmer plots and fluorescence lifetime results confirm the static quenching nature of the drug-DNA complex. The binding constant Kb was 2.5 × 104 L mol-1 and the number of binding sites are 1.17. The 5-FU on DNA system was calculated using double logarithmic plot. From the Forster nonradiative energy transfer study it has been found that the distance of 5-FU from DNA was 4.24 nm. In addition to the spectroscopic results, the molecular modeling studies also revealed the major groove binding as well as the partial intercalation mode of binding between the 5-Fluorouracil and herring sperm DNA. The binding energy and major groove binding as -6.04 kcal mol-1 and -6.31 kcal mol-1 were calculated from the modeling studies. All the testimonies manifested that binding modes between 5-Fluorouracil and DNA were evidenced to be groove binding and in partial intercalative mode.


Objective To observe the efficacy of small doses of oral Aspirin combined Iressa and Iressa in treating the non-small cell lung cancer, and analyze that contrastively. Methods 56 non-small cell lung cancer patients admitted in our department from November 2010 to November 2012 were collected and randomly divided into two groups. 28 patients in the research group were given small doses of oral Aspirin combined with Iressa for chemotherapy, and 28 patients in the control group were given Iressa for chemotherapy. The chemotherapy was not terminated until the disease progressed or the side effects could not be tolerated. The curative effect and adverse reactions of the two different schemes for tumor after 2, 4, 6 cycles of treatment were observed, and one-year survival rate of both groups of patients was observed through follow-up, and the data of the two groups were compared,analyzed and evaluated. Results The effective rate of the research group was 14.3%, and that of the control group was 10.7%, the difference was statistically significant(P0.05); the disease control rate of the research group was 78.6%, and that of the control group was 75%, the difference was not statistically significant(P0.05); The side effects of Iressa mainly were a transient loss of appetite, mild rash and diarrhea. The incidence of a transient loss of appetite and mild rash in the research group was 32.1%,39.3%, respectively, obviously lower than that(60.7% and 67.9%, respectively) in the control group, the differences were statistically significant(P0.05); the one-year survival rate in the two groups was 50% and 39.3%, respectively, the difference was not statistically significant(P0.05). Conclusion The treatment of small doses of oral Aspirin combined with Iressa has better clinical efficacy than the treatment of Iressa for non-small cell lung cancer. Aspirin can decrease the high blood coagulation state, improve the treatment efficiency and survival time in tumor patients, which also can reduce the time of tumor progression, thereby improving the quality of life of tumor patients.


We classify all two-dimensional fundamental integrable spin chains which have regular R-matrices of difference form. This means that the R-matrix underlying the integrable structures is of the form R(u,v)=R(u-v) and reduces to the permutation operator at some particular point. We find a total of 14 independent solutions, 8 of which correspond to well-known eight or lower vertex models. The remaining 6 models appear to be new and some have peculiar properties such as not being diagonalizable or being nilpotent. Furthermore, for even R-matrices, we find a bijection between solutions of the Yang-Baxter equation and the graded Yang-Baxter equation which extends our results to the graded two-dimensional case.


Acquiring the 137Cs reference inventory values is the first step for using 137Cs technique to estimate rates of soil erosion and sediment deposition. The 137Cs reference inventories distribution in China is calculated in this paper by using the model and software of the fallout 137Cs reference inventory, which is established by Walling and He. The modeling results are compared with the measured 137Cs reference inventories in China, and then some defects of the Walling and He's model of the fallout 137Cs reference inventory are indicated. In this paper, the 137Cs reference inventories distribution pattern of China and the major influence factors are analyzed too.


Abundance ratios relative to iron for carbon, nitrogen, strontium, and barium are presented for a metal-rich main-sequence star ([Fe/H] = -0.74) in the globular cluster ω Centauri. This star, designated 2015448, shows depleted carbon and solar nitrogen but, more interestingly, shows an enhanced abundance ratio of strontium [Sr/Fe] ≈ 1.6 dex, while the barium abundance ratio is [Ba/Fe] ≤ 0.6 dex. At this metallicity one usually sees strontium and barium abundance ratios that are roughly equal. Possible formation scenarios of this peculiar object are considered.


This must-have student resource contains complete solutions to all end-of-chapter problems in Genetics: Analysis of Genes and Genomes, Eighth Edition, by Daniel L. Hartl and Maryellen Ruvolo, as well as a wealth of supplemental problems and exercises with full solutions, a complete chapter summary, and keyword section. The supplemental problems provided in this manual are designed as learning opportunities rather than exercises to be completed by rote. They are organized into chapters that parallel those of the main text, and all problems can be solved through application of the concepts and principles explained in Genetics, Eighth Edition.


CONDYLOMATA ACUMINATA, ALTHOUGH NOT A FREQUENT PATHOLOGY, IS USUALLY ASSOCIATED WITH HUMAN PAPILOMA VIRUS (HPV) INFECTION IN VULVAR AND ANOGENITAL TRACT. IT IS ASSOCIATED WITH HPV 6 AND 11. TREATMENT OF CONDYLOMATA LESIONS REDUCES THE RISK OF HPV TRANSMISSION AND THEREFORE THE POSSIBILITY OF SECONDARY NEOPLASIA. HPV VULVAR AND ANOGENITAL TRACT INFECTION HAS THREE STAGES: CLINICAL, SUBCLINICAL AND LATENT. THE CLINICAL STAGE USUALLY HAS DIFFERENT CONDYLOMATA FORMATIONS IN THE VAGINA OR THE KERATIN EPITHELIA. LESIONS ASSOCIATED WITH THE SUBCLINICAL STAGE, MORE FREQUENTLY OBSERVED IN THE CERVIX, ARE ONLY FOUND BY COLPOSCOPY AFTER 5% ACETIC ACID TREATMENT. FINALLY IN THE LATENT STAGE WHICH LACKS MACROSCOPIC LESIONS THE PRIORITY IS TO DETECT VIRAL DNA. BOTH, CLINICAL AND SUBCLINICAL STAGES CAN BE ASSOCIATED WITH BENIGN MORPHOLOGICAL CHANGES SUCH AS CONDYLOMATA LESIONS OR INTRAEPITHELIAL NEOPLASIA. THE AIM OF THIS WORK IS TO PROPOSE A NEW CONDYLOMA LESION CLASSIFICATION BASED ON STAGES WITH THE INTENTION OF SUGGESTING AN ALGORITHM OF THERAPEUTICAL USEFULNESS. OUR PROPOSAL CONSIDERS THE SIZE, NUMBER AND LOCATION OF LESIONS AND IT ALSO RECOMMENDS THREE SUBGROUPS FOR EACH ONE ACCORDING TO CERTAIN WELL DEFINED CHARACTERISTICS MENTIONED IN THE TEXT. WE BELIEVE THAT OUR PROPOSAL IS A PRACTICAL WAY TO CLASSIFY THE CONDYLOMATA LESIONS OF THE LOWER ANOGENITAL TRACT THAT WILL HELP THE CLINICIAN DECIDE A CONVENIENT THERAPEUTICAL APPROACH WITH THE ADVANTAGE OF BEING SIMPLE TO USE.


at City Week 2018. As is to be expected, Brexit is omnipresent on the agenda. But, as the Belgian friar Dominique Pire said when he received the Nobel Peace Prize in 1958, "men build too many walls and not enough bridges". That is why I am not going to speak about what divides us, but rather about what unites us. We are and will always remain close friends and partners, even if we will no longer be in the same European club. Today I will elaborate on two challenges that should unite us in the near future: the utmost need for active multilateralism and the finance of tomorrow in an interconnected world.


The offered technology on bioremediation of petropolluted soils by use of microorganisms-destructors of oil with high activity on technological platforms at correct application allows to finish residual mainte-nance of oil to sanitary level during the vegetative period.


Antiplatelet drugs are widely used for the prevention and treatment of vascular diseases of the heart and brain. The most popular drugs are non-steroidal anti-inflammatory drugs, the first place among which still belongs to acetylsalicylic acid (aspirin) and its derivatives. However, along with high clinical efficacy according to target parameters, these drugs have side effects that lead to damage to the mucous membrane of the gastrointestinal tract (GI). In order to eliminate the effects of damage to the gastrointestinal tract with the use of antiplatelet drugs, based on salicylic acid, using a natural dipeptide carnosine, a new compound was synthesized - salicyl-carnosine, which has an antiplatelet effect. A comparative study on carnosine, acetylsalicylic acid and salicyl-carnosine for the healing of ulcerative defect was carried out on the model of acetate gastric ulcer by Okabe. It was shown that salicyl-carnosine was more effective than carnosine both at the stage of ulcer formation (1-5 s) and at the stage of healing (5-10 s). Acetylsalicylic acid in the used model of gastric ulcer not only did not prevent the development of gastric ulcer, but also complicated the healing processes. The results indicate the possible prospects for the use of salicyl-carnosine as an antiplatelet drug in vascular pathologies (cardiac, Central nervous system, etc.), to avoid side effects associated with damage to the gastrointestinal tract, inherent in aspirin and other NSAIDs. Non-steroidal anti-inflammatory drugs


As someone who has sat on selection panels for senior management posts in the NHS, Steve Ainsworth is often asked what sort of person we are looking for. How do we ensure equality? Who has the right stuff?


Mobile technologies have become a social reality in large parts of the developing world in general and in Africa especially. The large scale connected representativeness of access to and often ownership of mobile devices opens many doors to innovative, far reaching mobile-based applications and services. This near ubiquitous access, however, is characterized by an entirely new set of challenges as different legacy devices and cutting edge smartphones make up a cornucopia of end user realities. In order to reach as many end users as possible through the devices that they already own and are comfortable with, channel agnostic access is needed that would support the different mobile access channels using a variety of communications protocols. This paper outlines the various technical and operational considerations associated with the conceptualization of a middleware platform for mobile enablement and its application in the health environment as a mobile health monitoring system for community health workers.


Objective To explore the correlation between HLA-A, B alleles polymorphism and hemorrhagic fever with renal syndrome (HFRS) among Han nationality in Zunyi area. Methods Using group study, HLA-A, B genotypes were conducted in 100 HFRS cases and 100 controls among Han nationality in Zunyi area with polymerase chain reaction-sequence specific primer (PCR-SSP), gene frequency (GF) and relative risk (RR) were compared and calculated. Results The frequencies of HLA-A * 31 and HLA-B * 58 alleles in HFRS cases (GF=4%,12.5%) were strikingly higher than that in the healthy controls (X2=6.380, 7.792, P<0.05;RR=18.47,2.91). The frequencies of HLA-B * 40 alleles in HFRS cases (GF=11%) were strikingly higher than that in the healthy controls (X2=6.095,P<0.01, RR=O.47). Conclusion HLA-A * 31, B * 58 genes are positively related to HFRS of Han nationality in Zunyi area, HLA-B * 40 gene is negatively related to HFRS of Han nationality in Zunyi area.

Key words:
HLA-A;  B gene;  Hemorrhagic fever with renal syndrome (HFRS);  Correlation


The preparation of the teacher for the realization of the process of integral diagnosis of the schoolchildren is of great importance in the current didactics; this constitutes its basic principle. The general objective of the proposal lies in the identification of dimensions, indicators and requirements for the effective implementation of the comprehensive diagnosis of schoolchildren. The main results consist of a broader characterization of the basic functions of the teacher, so that the process of comprehensive diagnosis of the schoolchild constitutes: the first moment of the guiding function, by requiring the psycho-pedagogical characterization and the pedagogical prognosis; the centre of the teacher's research and improvement work, by demanding the identification and hierarchization of the student's problems from the school, and in close connection with the family and the community, the critical analysis of regularities during the application of the diagnosis, the inquiring attitude to explore the student's personality, and the constant search and theoretical updating on the subject of school diagnosis, and finally, the compass of the work of teaching-methodology, by establishing a close relationship between diagnosis and the components of the process that guide the planning, execution, control and evaluation of the teaching-learning process.


This document refers to a judgment of the Court of Valparaíso pronounced on the requirement to be considered a consumer under the Chilean Consumer Law. Accordingly, it refers to the right of security in consumption and the need to prove damages in order to claim them.


Subarcsecond localization of the repeating fast radio burst FRB 121102 revealed its coincidence with a dwarf host galaxy and a steady ("quiescent") nonthermal radio source. We show that the properties of the host galaxy are consistent with those of long-duration gamma-ray bursts (LGRB) and hydrogen-poor superluminous supernovae (SLSNe-I). Both LGRBs and SLSNe-I were previously hypothesized to be powered by the electromagnetic spin-down of newly formed, strongly magnetized neutron stars with millisecond birth rotation periods ("millisecond magnetars"). This motivates considering a scenario whereby the repeated bursts from FRB 121102 originate from a young magnetar remnant embedded within a young hydrogen-poor supernova (SN) remnant. Requirements on the gigahertz free–free optical depth through the expanding SN ejecta (accounting for photoionization by the rotationally powered magnetar nebula), energetic constraints on the bursts, and constraints on the size of the quiescent source all point to an age of less than a few decades. The quiescent radio source can be attributed to synchrotron emission from the shock interaction between the fast outer layer of the supernova ejecta with the surrounding wind of the progenitor star, or the radio source can from deeper within the magnetar wind nebula as outlined in Metzger et al. Alternatively, the radio emission could be an orphan afterglow from an initially off-axis LGRB jet, though this might require the source to be too young. The young age of the source can be tested by searching for a time derivative of the dispersion measure and the predicted fading of the quiescent radio source. We propose future tests of the SLSNe-I/LGRB/FRB connection, such as searches for FRBs from nearby SLSNe-I/LGRBs on timescales of decades after their explosions.


The influence of adding molybdenum and niobium on the microstructure and mechanical properties of C5 steel used in railway wheels was studied. The samples were heated to 1250°C and hot rolled in four passes, starting at 1200°C, undergoing a total reduction of 67%, followed by air cooling. After rolling between 1200 and 1120°C, it was found that addition of molybdenum and niobium resulted in an increase of mechanical strength while maintaining the same ductility and toughness.


Subtitle: Auctions are now big business, part of an industry that grosses more than $82 billion in volume. Buyers and sellers are savvier, and the Internet has brought speed and reach to this remarketing channel.


Introduction: The aim of our work was to analyze the incidence of tunneled hemodialysis catheters‐related thrombosis in hemodialyzed patients depending on catheter tip depth and position and to evaluate the impact of other established risk factors responsible for development of central venous thrombosis.


Women in Kenya are underrepresented in decision-making positions, which appears as a remnant of persisting cultural gender roles that limit women from participating in activities critical for personal, societal, and national development. Such retrogressive ideas regarding a large number of the country's citizens have to be addressed early in the life of a girl to build in girls' self-esteem and facilitate them to develop leadership skills. This study investigated the extent to which girls in primary schools in Voi sub-county are involved in leadership in their schools. The study was based on the 2010 Kenya's constitution which ruled that no more than two-thirds of elected or appointed public institutions leaders should consist of one gender. The new legal framework seeks to break down the barriers women face in realizing their political, civil, economic, and social rights. It also ensures that women are involved in decision-making at all levels of government. In this study, data was collected from three mixed primary schools in Voi sub-county given codes A, B, and C. School A had a total of 470 pupils; 225 were boys and 245 were girls and the school had 21 leadership positions. The findings showed that the majority 14 (66.7%) of the leadership positions were occupied by boys while the few 7 (33.3%) were occupied by girls. In school B, there were a total of 1,056 pupils; 498 were boys and 558 were girls. There were 13 leadership positions. The majority of the positions 7 (53.8 %) were occupied by boys and minority 6 (46.2%) were occupied by girls. In school C, there were a total of 1,450 pupils and 680 were boys and 770 girls. There were 13 leadership positions. The majority 7 (53.8%) of the positions were occupied by boys while 6 (46.2%) were occupied by girls. In all the schools, there were more girls than boys but boys occupied more leadership positions than girls. Boys also took senior positions and girls were their deputies and were not as active as boys in areas such as class discussions and debate. It was recommended that conscious effort should be made to develop leadership skills in girls during their formative years.


The main objective of this research was to compare the results of the psychomotor evaluation between two groups of students, both belonging to the same school, in the city of Uruguaiana / RS. The present study analyzed 42 girls, aged between 11 and 13 years old, all from the Dom Hermeto State High School, in the municipality of Uruguaiana, and each group was composed of 21 girls, all from different classes and years. Among the 42 girls, 10 were of the 5th grade, 17 of the 6th grade and 15 of the 7th grade, all classes of the morning shift. The instrument used in this research, besides a mini-questionnaire to identify the history of the sports life of the students, was the BPM of Fonseca (1995), which provides a protocol for solving the student's psychomotor profile through the evaluation of seven factors psychomotors (Tonicity and Equilibration, Lateralization, Body Notion and Spatial-Temporal Structuring, Global Praxia and Fine Praxia). The results were in agreement with the objectives and the problems of this research, which demonstrated the possibility of measuring whether sports training provides above-normal psychomotor development for physically trained children when compared to untrained children. With this research we can demonstrate that sports practice from the earliest years of elementary education and from the primary in early childhood education can help children with motor learning difficulties. The average of the psychomotor profile of the trained students was 5.81% higher than the average of the untrained students. This study demonstrated the possible difference and elucidation of some of the benefits of practicing sports or any other physical activity since childhood.


. Detecting damage in transportation infrastructure structures es is particularly important to ensure safety and structural integrity. Using optimal algorithms in structural health monitoring has shown promising results in recent years. Among them, the artificial rabbits optimization (ARO) algorithm is one of the newest optimal algorithms applied to many optimization problems, including structural health monitoring. This article introduces the potential of ARO in diagnosing damage to suspension footbridge. A finite element model of the bridge will be built, and scenarios of damage will be simulated. The results show that ARO is effective in identifying damage in structures and its performance is equivalent to other optimal algorithms such as the teaching-learning-based optimization algorithm (TLBO), the cuckoo search algorithm (CS), the genetic algorithm (GA), and the swarm optimization algorithm (PSO). Moreover, ARO demonstrates superiority in terms of accuracy and computation time.


To analyze the main synthetic route for the study of the synthesis process of bilastine and its important intermediate.The results showed that the two-step synthesis method of the key intermediate had the advantages,avoiding long reaction steps and harsh reaction conditions of the other methods,and readily available raw materials,simple operation and low cost,friendly environment,more suitable for industrial production.


Atherosclerosis is an inflammatory disease that last for a long time with unseen progress. In the previous research, the assumption on red ginger as anti atherosclerosis agent is strengthened by lipid profile improvement compared to simvastatin. This study aimed to discover the active fractions from red ginger rhizomes to be developed further as anti-atherosclerosis agents. The selections are based on antioxidant activities. The antioxidant activities are assessed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) also cupric ion reducing antioxidant capacity (CUPRAC) method. The antioxidant activity measured by DPPH, ABTS and CUPRAC methods revealed red ginger rhizomes ethyl acetate fraction had the lowest IC50 (23.25 ± 10.74 µg/ml; 27.36 ± 6.43 µg/ml; and 15.17 ± 0.60 µg/ml). Blois classification indicated that ethanol extract and ethyl acetate fraction of red ginger rhizomes are potent antioxidants, while red ginger rhizomes essential oils classified as medium antioxidant by DPPH and CUPRAC method, as well as weak antioxidant by ABTS method. In conclusion, ethyl acetate fraction is the prime candidate for further development as anti-atherosclerotic agent.


This publication covers different themes in the field of assistive technology. The theme New technologies will explore the significant advances in technology research & development and how these can be harnessed to benefit people with disabilities. This will include evolving technologies, affording interesting insights into the future. The theme User Centred Approach will look at fundamental ways in which the EU advocate a philosophy of citizenship and governance and how this philosophy can be advanced to ensure that people with disabilities become central to the assistive technology process Another issue that is explored in this publication is Interdisciplinary Approaches which can be developed within assistive technology and the provision of services to people with disabilities. Finally, it concentrates on ways in which practitioners and users, working together within assistive technology, can achieve best practice in the development and implementation of Guidelines and Standards across a broad spectrum.


students to negotiate and explore the complexities of writing without the compulsions of many of the politically problematic commonplaces of composition pedagogy. We use zines to examine the unique ways in which their rhetorical devices address conflicts around questions of audience and diversity, as well as the particular questions that the zines raise about the politics of persuasion, our own writing practices, writing strategies that the zines suggest to us, and the construction of alternative communities.


Background: The Würzburg bleb classification score (WBCS) serves to assess filtering blebs in a standardized fashion. The purpose of this prospective masked agreement study was to evaluate the WBCS interobserver variability. Methods: The WBCS provides a scheme to grade clinical bleb morphology. It evaluates the following parameters: vascularity, corkscrew vessels, encapsulation, microcysts and bleb height. Thus, 113 eyes of 104 consecutive patients at various times after surgery were examined (slit lamp biomicroscopy) by 3 ophthalmologists with each observer being unaware of the findings reported by the others. To calculate the interobserver variability of the WBCS, the interobserver consistency and absolute agreement were determined with an intraclass correlation coefficient (ICC) using a 2-way random model. Results: The ICC values of a single rater's judgment were: vascularity +0.62, corkscrew vessels +0.67, encapsulation +0.63, bleb height +0.53, microcysts +0.52 and total score +0.74. The ICC values of the mean of all 3 raters were: +0.83 vascularity, +0.86 corkscrew vessels, +0.84 encapsulation, +0.77 bleb height, +0.76 microcysts and +0.90 total score. Conclusion: The WBCS is a bleb morphology score with high levels of interobserver consistency and absolute agreement in clinical practice.


Background: Premature rupture of membranes (PROM) is an obstetric condition that involves spontaneous amniotic fluid leakage at least one hour before onset of labor complicates 5-10% of all deliveries. Its etiology is multi-factorial as polyhydramnios, cervical incompetence, congenital uterine abnormality, trauma and previous cervical biopsy.
Objective: To assess the effect of vaginal colonization with group B streptococcal infection on the incidence of premature rupture of membranes and how to prevent its complications in pregnant women.
Patients and methods: This was a prospective study included the period between December 2018 till May 2020 and was conducted on one hundred and forty (140) pregnant women suffered from vaginal infection with group B streptococcal infection selected from the antenatal Care Clinic of the Obstetrics and Gynecology Department of Al-Azhar University Hospitals and Sedi Salem General Hospital. Pregnant women with single viable fetus, gestational age after 28 weeks, and those with no past history of premature rupture of membranes were included in this study. Those with polyhydramnious, UTI, dead fetus, Diabetes mellitus, congenital fetal malformation, multiple pregnancies and with fibroid disease were excluded from this study.
Results: The presence of vaginal infection increase the incidence of premature rupture of membranes, especially if those infections were due to streptococci group B, premature rupture of membranes increased.
Conclusion: The presence of vaginal infections increased the incidence of PROM more.


Lake and reservoir water quality is impacted greatly by the input of momentum, heat, oxygen, sediment, nutrients and contaminants delivered to them by riverine inflows. When such an inflow is negatively buoyant, it will plunge upon contact with the receiving ambient water and form a gravity-driven current near the bed (density current). If such a current is sediment-laden, its bulk density can be higher than that of the surrounding ambient water, even if its carrying fluid has a density lower than that of the surrounding ambient water. After sufficient sediment particles have settled however, the buoyancy of the current can reverse and lead to the plume rising up from the bed, a process referred to as lofting. In a stratified environment, the river plume may then find its way into a layer of neutral buoyancy to form an intermediate current (interflow). A deeper understanding of the wide range of hydrodynamic processes related to the transitions from open-channel inflow to underflow (plunging) and from underflow to interflow (lofting) is crucial in predicting the fate of all components introduced into the lake or reservoir by the inflow.

Field measurements of the plunging inflow of the negatively buoyant Rhône River into Lake Geneva (Switzerland/France) are presented. A combination of a vessel-mounted ADCP and remote sensing cameras was used to capture the three-dimensional flow field of the plunging and lofting transition zones over a wide range of spatial and temporal scales.

In the plunge zone, the ADCP measurements show that the inflowing river water undergoes a lateral (perpendicular to its downstream direction) slumping movement, caused by its density surplus compared to the ambient lake water and the resulting baroclinic vorticity production. This effect is also visible in the remote sensing images in the form of a distinct plume of sediment-rich water with a triangular shape leading away from the river mouth in the downstream direction towards a sharp tip. A wide range of vortical structures, which most likely impact the amount of mixing taking place, is also visible at the surface in the plunging zone.

In the lofting zone, the ADCP measurements show that the underflow undergoes a lofting movement at its edges. This is most likely caused by a higher sedimentation rate due to the lower velocities at the underflow edges and leads to a part of the underflow peeling off and forming an interflow, while the higher velocity core of the underflow continues following the bed. Here, the baroclinic vorticity production works in the opposite direction as that in the plunge zone. Further downstream, as more particles have settled and the surrounding ambient water has become denser, the remaining underflow also undergoes a lofting motion. The remnants of these lofting processes show in the remote sensing images as intermittent ‘boils’ of sediment rich water reaching the surface and traces of surface layer leakage.


Microbes in soil play a major role in the release of NO into the atmosphere and thereby indirectly impact to the radiative forcing. In this study DAPI cell counting, Clone libraries for RNA and a H2O Stable Isotope Probing (SIP) for DNA were used to identify microbial activity over different soil moisture contents within a drying out. An optimum function for the DAPI cell counting was observed for the drying out. Within a series of clone libraries over the drying out footprints for several genera of the classes Alphaproteobacteria, Gammaproteobacteria and Bacilli, Planctomycetacia, Fusobacteria, of microbial activity could be identified. By the use of qPCR for the SIP fractions it could be shown that the DNA is significantly labelled with O even in really short incubation times of ~9h. For further conclusions, in a future study the samples will be parameterized for their release of trace gases. Thomas Behrendt Max Planck Institute for Chemistry Microbial Diversity Summer Course 2012 Marine Biological Laboratory, Woods Hole, MA


We have developed a simple method for analysing gravity data to define 3D subsurface structures consistent with geological maps and reflection seismic survey results. This new method makes it possible to automatically separate gravity anomalies caused by structures that are the target of analysis (residual gravity) and not subject to gravity anomaly analysis (trend surfaces or regional gravity variations). This separation is achieved by assuming that the gravity anomaly trend surface is extremely smooth prior to analysis. In addition, this analysis can be carried out automatically, so it is possible to use a boot-strap simulation to evaluate the effect that gravity data accuracy and survey point distribution have on the analysis results. Using this newly developed method, we conducted a 3D subsurface structural analysis based on newly obtained gravity survey data in an area around Iwaki City, Fukushima Prefecture. The results of the 3D structural analysis revealed sharp depressions in the basement rock and basin-shaped underground structures along the Yunodake and Yamada faults. Finally, we were able to estimate the influence of survey point distribution and abrupt changes in the structure on the analysis results using a boot-strap simulation of the 3D analysis. We propose a simple method for analysing gravity data to define 3D subsurface structures based on automatic separation of gravity anomalies into residual gravity and trend surfaces. This is achieved by assuming that the gravity anomaly trend surface is extremely smooth prior to analysis. The new method was applied to an area around Iwaki City, Fukushima Prefecture, Japan, and the results evaluated using a boot-strap simulation.


At present,public security education is confronted with the situation of weak practical teaching system,so it is important that public security education must insist on the practical teaching. Therefore,we should improve the teaching mode in the course of Forensic Drug Chemistry,aiming at cultivating professional police candidates with practical experiences and innovative skills. Meanwhile,with reorganizing the teaching content,innovating the teaching methods and introducing the new evaluation system,we should adjust our practical teaching mode to the changing situation in order to help students to promote their accumulation and application of knowledge,as well as the practical ability.


Author(s): Canez, Jorge | Advisor(s): Monkkonen, Paavo | Abstract: The road safety Vision Zero policy of the City of Los Angeles is failing to prevent pedestrian fatalities and severe injuries. Since its implementation in 2015, tragic pedestrian crashes are increasing annually. This research studies the socio-demographic profiles of these pedestrians victims of traffic violence at the neighborhood level, and the political obstacles that prevent the redesign of the streets form the murderous car-oriented status quo to a peaceful people-oriented built environment. First, I assess the correlation between non-white, polluted census tracts, and pedestrian fatalities and severe injuries, and find that it is positive and statistically significant. At the same time, the median income, vulnerable age, and the number of cars in a household does not have a statistically significant relationship with pedestrians' road safety. I also found that in the City of LA, black people are only 8% of the population, but 20% of all pedestrian fatalities, being the ethnic group more overrepresented. Then, through interviews and a literature review, I identify the principal political obstacles to implementing pedestrian road safety infrastructure. There is a constant backlash from car-oriented neighbors, and the authorities are failing to support residents who demand pedestrian improvements. Based on the research, my main policy recommendation is to revive and strengthen the Vision Zero Dignity Infused Community Engagement strategy (DICE) of the Los Angeles Department of Transportation (LADOT). This program should continue building power and developing capabilities in communities, especially in historically underserved areas, towards a critical mass of residents fighting for safe streets.r


Introduction: calcifying fibrous tumor (cFt) is a rare, benign soft tissue tumor of unknown etiology. Previously reported in the subcutaneous and deep tissues of the extremities and trunk, sporadic accounts of intra-abdominal cFts associated with the peritoneum, mesentery and bowel have recently arose. case report: We present a previously unreported entity of a free-floating intra-abdominal presentation of cFt. We discuss its classical histological and immunohistochemical findings, possible differential diagnoses, and its implications on clinical management. conclusion: calcifying fibrous tumor (cFt) should be considered as a possible differential diagnosis of free-floating peritoneal masses


Objective: To investigate the effect of No.1 self-made formula on alcohol-induced hepatic injury of mice.Methods: Mice model with alcoholic liver injury were established by gastric perfusion of 50% ethanol.Levels of triglyceride,triglyeride in serum,malondialdehyde(MDA) and glutathione(GSH) were measured,and pathological examination was also performed.Results: It showed that MDA and TG level decreased significantly,and the hepatic pathological status was obviously improved and it was dose-dependent.The indexes in high dose group were similar to these in control group.Conclusions: No.1 self-made formula has remarked protective effect on hepatic injury due to alcohol.


Diphenyl ether is a very important pesticide intermediate. The nano-CuI was prepared in microemulsion which was applied to C-O cross-coupling reaction. Excellent yields of corresponding products were achieved in mild conditions.Such method could be applied in pesticide syntyesis.


The experiment was conducted with HSP21.4 gene.Adding Sac I site to the endpoints of objective genes by using PCR amplification,then ligated with pBI121.The recombinant plasmid was transferred into competent cells of Escherishia coli DH5α.The PCR and Sac I digestion test showed that the HSP21.4 gene was constructed into plant expression vector,and recombinant plasmid designated as pBI-CpHSP21.4.The recombinant plasmid was transferred into competent cells of Agrohacterium tumefaciens LBA4404.One A.tumefaciens clone harboring recombinant plasmind pBI-CpHSP21.4 was obtained.It lays a foundation for testing function of HSP21.4 gene and transgenic plant expressing.


Abstract : The Defense Strategic Guidance, published in January 2012, describes a rebalance toward the Asia-Pacific region and provides implementation guidance. This guidance places high priority on relationships with allies and partners and directs relationship expansion throughout the theater. The AirSea Battle concept has ignited a debate on the role of landpower in the Asia-Pacific, as well as the Army's role in ASB. But the argument should not be How can the Army get into the Pacific? The Army is already there and has been for decades. ASB as a strategy, while a useful and necessary approach to portions of the Asia-Pacific security challenge, neglects the reality of partner nation defense establishments which are overwhelmingly dominated by land forces both in sheer numbers and leadership. The majority of the Asia-Pacific security apparatus is land centric; therefore, landpower is critical to execute the guidance. This paper examines how landpower can be applied to build and strengthen relationships while keeping U.S. forces trained and ready, and the paper demonstrates why landpower could become a main effort in achieving desired end states.


The era of big data has had a more accurate, timely, extensive and lasting impact on the way of thinking and behavior of college students, which puts forward the reform requirements of "sense of the times" and "attraction" for ideological and political education in colleges and universities. However, the dilemmas in the process of combining the two are objective, such as the problems of the traditional subject-object relationship between the ideological and political educators and college students and the top-level design of school administration. Therefore, a two-way transformation combining top-down and bottom-up is the era requirement for traditional ideological and political education in the era of big data.


Meat foods are the main vehicle of foodborne diseases as a result of poor handling during processing. The objective of this study was to determine the frequency and antibiotic resistance factors of Escherichia coli in TIF plants of the Estado de Mexico. For this, 3 Federal Inspection Type (TIF) plants in Mexico were analyzed, with n = 90 samples, 10 raw meat product (beef, pork and turkey meat), 10 finished meat product and 70 work tools. Eighteen (20%) E. coli strains were isolated (3 raw meat product, 2 finished meat products and 13 work tools (P > 0.05). The E. coli isolates showed high levels of resistance to ampicillin (88.8%), cephalothin (88.8%), carbenicillin (83.3%) and chloramphenicol (61.1%). There was a relationship between E. coli strains resistant to ampicillin and chloramphenicol and presence of resistance genes Pse-1 4/18 (22%) and floR 4/18 (22%). Five (55.5%) positive isolates to Pse-1 and flo R, also exhibit the Cs3 Cs5 genes for the class I integrons. The results indicate that antimicrobial resistance and genetic resistance factors are present in Escherichia coli isolated from food processing plants, suggesting that they can be transmitted to the intestine microbiota of human population by contamination and consumption of improperly processed products and become a risk factor for public health.


Correspondence (İletişim): Arzu Yıldırım Ar, M.D. Saglik Bilimleri Universitesi, Fatih Sultan Mehmet SUAM, Anesteziyoloji ve Yogun Bakim Klinigi, Istanbul, Turkey Phone (Telefon): +90 505 382 27 29 E-mail (E-posta): email@example.com Submitted Date (Başvuru Tarihi): 11.06.2019 Accepted Date (Kabul Tarihi): 17.07.2019 Copyright 2019 Haydarpaşa Numune Medical Journal OPEN ACCESS This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/). 348 Yıldırım Ar et al., Evaluation of Intensive Care Patient Bed Cleanliness by ATP Bioluminescence / doi: 10.14744/hnhj.2019.02360 Resilience, virulence, ease of transfer, ability to colonize or infect patients, biofilm formation capacity and tolerance capacity of pathogens to antiseptics, disinfectants, or surface materials are important in environmental contamination and spread of pathogens. Furthermore, many factors, such as effective and frequent cleaning of the environment, isolation facilities, hand hygiene and antimicrobial consumption, are effective in reducing environmental contamination [5]. Apart from the training of hospital staff in environmental cleaning, a system that will control the reliability of cleaning is required. Thus, visual assessment of the environment, microbial methods, fluorescent marker, ATP (Adenosine Triphosphate) bioluminescence methods are being used [5–7]. ATP is present in all living cells. ATP is also an important building block in energy transfer reactions. ATP bioluminescence method can be defined as measuring the intensity of light emitted by enzymatic reactions. Bioluminescence is common in marine bacteria, fungi, some marine organisms, saltwater fish and fireflies in nature. The ATP bioluminescence method measures the presence of ATP on surfaces. This method is based on the reaction of ATP with the luciferin-luciferase enzyme to give bioluminescence light and measurement of this light by luminometer. On a standardized area, a sample is taken with a swap. Then, ATP reacts with luciferase to form Adenosine Monophosphate (AMP), which is measured with a bioluminometer and converted to numerical value as a relative light unit (RLU) [6, 8, 9]. This study aims to document and present the results of ATP measurement to observe environmental contamination at a time when infection rates have increased in our clinic. Materials and Methods Our intensive care clinic has 20 beds with a 100% occupancy rate. Health service providers are serving as shift workers from 08.00 to 16:00 and 16:00 to 08:00. Nine-ten nurses and three-four staff are employed during each shift period. Approval of the scientific studies board of our hospital (17073117-050.99) was obtained for this study. In our study, we retrospectively evaluated the results of ATP bioluminescence measurements that we performed on three different days in December 2017. Before and after cleaning the same area of 5x20 cm on the side edge of each bed we determined beforehand, with the disinfectant (40% n-Alkyl Dimethyl Benzyl Ammonium Chloride, 60% Urea) that we use for the routine cleaning, measurements with ATP Clean Trace (3M Company-USA) instrument were made and recorded as RLU. The threshold value for surface cleaning is between 100-500 RLU. In our clinic, we consider the most commonly used 250 RLU as a threshold value for similar surface cleaning [2]. When the value above 250 RLU was observed after cleaning, the cleaning was repeated and the measurement was renewed and recorded again. Statistical Analysis When evaluating the findings obtained in this study, IBM SPSS Statistics 22 for statistical analysis (SPSS IBM, Turkey) programs were used. While evaluating the study data, the suitability of the parameters to normal distribution was evaluated by the Shapiro-Wilks test and it was found that the parameters did not show normal distribution. Wilcoxon sign test was used for intragroup comparisons of the parameters before and after cleaning. Statistical significance was evaluated at p<0.05.


This thesis developed a method for real-time and handheld 3D temperature mapping using a combination of off-the-shelf devices and efficient computer algorithms. It contributes a new sensing and data processing framework to the science of 3D thermography, unlocking its potential for application areas such as building energy auditing and industrial monitoring.

New techniques for the precise calibration of multi-sensor configurations were developed, along with several algorithms that ensure both accurate and comprehensive surface temperature estimates can be made for rich 3D models as they are generated by a non-expert user.


Meteoroids are known to pose a threat to spacecraft; they can puncture components, disturb spacecraft attitude, and possibly create secondary electrical effects. Accurate environment models are therefore critical for mitigating meteoroid-related risks. While there are several meteoroid environment models available for assessing spacecraft risk, the uncertainties associated with these models are not well understood. Because meteoroid properties are derived from indirect observations such as meteors and impact craters, the uncertainty in the meteoroid flux is potentially quite large. We combine existing meteoroid flux measurements with new radar and optical meteor data to improve our characterization of the meteoroid flux onto the Earth and its velocity distribution. We use data extracted from the NASA all-sky network, the Canadian Automated Meteor Observatory, and the Canadian Meteor Orbit Radar. We improve our characterization of the observed meteoroid speed distribution by incorporating modern descriptions of the ionization efficiency (e.g., Thomas et al., 2016). We also present estimates of the uncertainties associated with our meteoroid flux distribution. Finally, we discuss the implications for spacecraft. Our model is constrained by the cratering rate on the space-facing surface of LDEF, and thus the risk posed to spacecraft by meteoroid-induced physical damage is the least uncertain component of our model. Other sources of risk, however, may vary. For instance, a lower average meteoroid speed would require a higher meteoroid mass flux in order to match the LDEF crater counts, leading to higher predicted rates of attitude disturbances.


The Polymer R&D Group at Swerea KIMAB AB (former Swedish Corrosion Institute) has more than 30 years of experience of the use of polymeric materials in process equipment. The core of our work lies ...


PURPOSE: A lifespan testing device for a thermoelectric generating module is provided to precisely test the characteristics applying to the thermoelectric generating element as a shearing force and evaluate the lifespan in a short time. CONSTITUTION: A lifespan testing device for a thermoelectric generating module includes a low temperature heat exchange element(31) serving as a circulation channel of a coolant for heat exchange with the outside, a temperature-variable heat exchange element(32) mounted correspondingly to the low temperature heat exchanger for forming a space with the low temperature heat exchanger to receive the thermoelectric module, a coolant supplying element(33) for supplying coolant below a predetermined temperature to the low temperature heat exchange element and/or the temperature-variable heat exchange element, a hot medium supplying element(34) for supplying a hot medium higher than a predetermined temperature to the variable-temperature heat exchange element, opening and closing elements(37) for opening or closing channels of the coolant or the hot medium to be supplied to the temperature-variable heat exchange element, and a control element(40) for controlling the channel opening/closing operation of the opening and closing elements.


In this work we present an investigation on a conductive thermoplastic nanocomposite used as flexible and stretchable strain gauge to be applied on inflatable structures for both terrestrial and extra-terrestrial applications. In particular we analysed the sensor behaviour by using an one-dimensional expansion system for increasing strain up to 5% and we studied the device changing in temperature. The strain gauge was also tested after several expansion cycles thus analysing the sensor response in time and ageing effects. Finally we tested the sensor on an inflatable naval fender in order to reproduce the sensor behaviour in real conditions.


Hydroxamic acids are salt free, organic compounds with affinities for cations such as Fe, Np and Pu and have been identified as suitable reagents for the control of Pu and Np in advanced nuclear fuel reprocessing. The results of a UV-visible-near IR spectrophotometric study of the 1:1 and 2:1 complexes formed between formoand acetohydroxamic acids (FHA, AHA) and Np(IV) ions are interpreted using speciation diagrams for the identification of the species present at diferent pH and ligand to metal ratios. A kinetic model that describes the instability of the complex due to the hydrolysis of the hydroxamate moeity, previously developed for the Fe(III)-AHA complexes [1], is tested here against experimental Np(IV)-FHA data. Consequently, the complexation constant for formation of the 1:1 Np(IV)-FHA complex in nitric acid is estimated at K1 = 2715, and indications are that complexation protects the ligand against hydrolysis at 0.1 > pH > -0.1.


This article describes the synthesis of silver nanoparticles using the aqueous extract of Alternanthera sessilis as a reducing agent by sonication, espousing green chemistry principles. Biologically synthesized nanoparti-cle-based drug delivery systems have significant potential in the field of biopharmaceutics due to its smaller size entailing high surface area and synergistic effects of embedded biomolecules. In the present work the cytotoxic effect of biosynthesized silver nanoparticles studied by MTT assay against breast cancer cells (MCF-7 cell line) showed significant cytotoxic activity with IC 50 value 3.04 l g/mL compared to that of standard cisplatin. The superior activity of the silver nanoparticles may be due to the spherical shape and smaller particle size 10–30 nm as confirmed from transmission electron microscope (TEM) analysis. The data obtained in the study reveal the potent therapeutic value of biogenic silver nanoparticles and the scope for further development of anticancer drugs.


Nowadays, continuous chemical processes ('flow chemistry') using micro process technology are becoming highly competitive, both for cost (better selectivity, higher productivity) and sustainability (low environmental impact) reasons. The first needs true process intensification and the second, among others, new eco-efficient starting and product materials. In this context, a new application for glycerol is reported with increasing industrial interest and tested here under highly intensified conditions. Starting from prior batch processing experience, it is reported about the transfer to a continuous process to transform dichloropropyl pivaloate, prepared from glycerol, into 3-chloro-2-hydroxypropyl ester. The continuous microreactor based process has up to three orders-of-magnitude reduced reaction times (5760×) by virtue of exploiting unusual experimental conditions in organic chemistry (Novel Process Windows), i.e. superheated pressurised processing much above the boiling point. The yields are fully comparable with the ones obtained under batch conditions, but with (expected) loss in selectivity through enhanced diproduct formation. This principally enables the new continuous process to target much higher productivities; however this also results in a more complex reaction mixture therefore the ease of separation and commercial value of the second product will decide its exploitation. Beyond such benefits for the individual reaction under investigation, this is among the very first reports about a superheated reaction with a distinct selectivity issue with two known byproduct pathways, and thus provides the first respective generic information after an upheavalled reporting on capillary- or microreactor-based superheated processing, so far mostly done for less complex reactions.


A trend in master of business administration (MBA) programs has been to offer more specializations beyond the traditional broad MBA. In this article, the authors explore the recruitment practices of business and the curricula of MBA programs comparing general MBA degrees with MBA degrees with specialization. The authors empirically examine whether employers prefer a general MBA or an MBA with a specialization. On the basis of an analysis of 758 employment advertisements and 27 MBA programs being offered by universities, the authors found a disconnection between what employers appeared to want and what business schools offered.


The toxicities of four insecticides and a herbicide to Tilapia macrochir were tested in the laboratory. The 24 hour LC50's were estimated as follows:
Endrin 20% ,0.008 ppm; Lindane 5% granules, 4.6 ppmm; Synexa 50 (HCH) 50%), 5.6 ppm; Synex 25 (HCH 25%), 14.8 ppm; TOK herbicide (Nitrofen), 100% survival for 24 hours at 100 ppm. These estimates agree with results obtained by other workers elsewhere in the world. The laboratory determination of toxicity is important in estimating the direct effects of poisonous substances on fish, but other indirect effects may result from their use. These should be investigated in the field.


There always exists uncertainty which is mainly due to uncertainty of the evaluation of a geotechnical structure at a site. The uncertainty in the geotechnical analysis can be considered in the probabilistic analysis using the Monte Carlo Simulation. It needs various soil profiles which could be possible at the target site. In this study, a new method is proposed to generate soil profiles which are probable at the site. The proposed method analyzes a structure of a site and generates one dimensional soil profiles for a probabilistic analysis. Through the field application, the applicability of the prosed method was shown.


High Altitude Long Endurance (HALE) platforms are a type of Unmanned Aerial Vehicle (UAV). With their relatively easy deployment and independence of a fixed orbit, HALE UAVs have the potential to re ...


HE use of early partial egg production records as a selection criterion for Timproving annual egg production was proposed by DEMPSTER and LERNER (1947). Their proposal was based on the contention of DICKERSON and HAZEL (19%) that genetic gain should be based on a unit of time, and that under certain conditions the genetic gain per unit of time could be increased by reducing the age of the parents. Further theoretical confirmation that the special case of selection on partial records to improve annual egg production met the required conditions was presented by LERNER and CRUDEN (1948), MADDISON (1954) and MORRIS (1956) based on parameter estimates in different populations. Further support for this hypothesis was provided by ERASMUS (1962) from what appear to be phenotypic correlation effects, and VAN VLECK and DOOLITTLE (1964) from genetic parameter estimates in the Cornel1 control population. Parameters estimated from still another population by OLIVER, BOHREN and ANDERSON (1957) indicated that this population should also gain more rapidly in annual record by selection on partial egg records to January 1 (approximately 40 weeks of age), than from selection on annual record. Furthermore, the parameter estimates obtained led to the conclusion that even greater gains in annual record could be achieved in that population by selecting on percent production to a fixed age (a measure of rate) rather than on number of eggs to a fixed age, which is influenced by both rate of production and age at maturity, Empirical evaluations of the hypothesis are difficult. MORRIS ( 1963) found that selection on part record egg numbers yielded direct response in part record for 12 generations, but that response in annual record ceased to increase after about four generations. Similar results from 10 and 11 generations of selection on number of eggs to 275 days of age in two strains were reported by GOWE and STRAIN (1963). MORRIS (1964) obtained parameter estimates in one of his populations which led to his suggestion that selection on percent production to a fixed age as pro-


HE comparisons and contrasts between India and Africa Tstood out dramatically. I found throughout the nine weeks that I was travelling in East Africa that there were constant letters in the East African Standard under the title of this article. The references of Mr. Nehru to Africa and the activities of his able but not overly tactful Commissioner in East Africa have raised the wrath of the European settlers. A by-product of Mau Mau has been the sharpening of racial feelings between all the races of this troubled area. Not only do the settlers assert that Indian have sold arms to the Kikuyu but also such fantastic stories are current as that Mr. Nehru applied to Mr. Trygve Lie when Secretary-General of the United Nations for "the Mandate" for Tanganyika-this I was asked to believe in all seriousness by a prominent European leader who was offended by my comment: "that's a good story !"


The Internet of Things (IoT) is one of the most trending technologies of the current era and is expected to cover a significant share of the global market in future. It connects physical objects to make them control and work for our daily chores; making it get its application in different fields of automation, thus reducing human effort. The objective of this paper is to emphasize on the different influencing aspects of IoT, namely Technology, Business and Society. After going through different journals, survey papers, blogs, newsletters, books and other information sources in this field, we pointed out the major Technological challenges of IoT; reviewed some relevant Business matters; and brought forward some affecting Social issues. We start this paper by presenting a brief overview of the IoT, and finally draw a relation among the different aspects of it.


333Background: The role of Helicobacter pylori-associated methylation in the inactivation of tumour-suppressor genes has been previously investigated. However, the relationship between H. pylori-as...


The James Webb Space Telescope (JWST), currently scheduled to launch in 2021, will dramatically advance our understanding of exoplanetary systems with its ability to directly image and characterize planetary-mass companions at wide separations through coronagraphy. Using state-of-the-art simulations of JWST performance, in combination with the latest evolutionary models, we present the most sophisticated simulated mass sensitivity limits of JWST coronagraphy to date. In particular, we focus our efforts towards observations of members within the nearby young moving groups β Pictoris and TW Hya. These limits indicate that whilst JWST will provide little improvement towards imaging exoplanets at short separations, at wide separations the increase in sensitivity is dramatic. We predict JWST will be capable of imaging sub-Jupiter mass objects beyond ∼30 au, sub-Saturn mass objects beyond ∼50 au, and that beyond ∼100 au, JWST will be capable of directly imaging companions as small as 0.1 MJ − at least an order of magnitude improvement over the leading ground-based instruments. Probing this unexplored parameter space will be of immediate value to modelling efforts focused on planetary formation and population synthesis. JWST will also serve as an excellent complement to ground-based observatories through its unique ability to characterize previously detected companions across the near- to mid-infrared for the first time.


The following work had as objective the elaboration of a content control system of the microsites of the academic units at ESPAM MFL that would allow to show, update and modify all type of information that is handled in the institution, whether galleries, events, news, projects, work team. The agile SCRUM methodology was used, which provides the necessary guidelines for the development of applications and consists of three phases. The first phase is the iteration planning, which includes the collection of the functional requirements of the system applying the IEEE 830 standard, the cases of use were also designed and the sprints that define the functional structure of the system from the point of view were planned from the user´s point of view. In the execution phase, we proceeded with the development of the web system: using the PHP technology tool with the Laravel development framework, with the MySQL database manager. In the last phase of inspection and adaptation, the respective delivery of the documentation was made, as is the user and programmer's manual, with the system completed based on the requested requirements.


The article dials with the study of the problems of native local history. The article is dedicated the investigation of papers of well-known historian A.P. Shapov. These papers consider the peculiarity of development russian regions. The article analyses main aspects of Shapov's regionalism.


This study is done to identify the attitudes of social work students towards LGBT individuals and to determine their levels of social justice advocacy skills and to analyse the relation between these attitudes. Ankara and Baskent Universities, which are located in Ankara and have official permission for research, constitute third and fourth grade social work students (n = 216). After analysis when the relationship between Homosexuality Attitude Scale score and subscales scores of Social Justice Advocacy Attitudes examined, there is no statistically significant relationship between homosexuality attitude scale scores and collaborative action, strengthening of the applicant, social / political advocacy, applicant / community advocacy, social justice advocacy total scores (p> 0,05 ).


In a scenario with two mutually distrusting players, Oblivious Transfer, a rather fundamental primitive in the design of cryptographic protocols, cannot be implemented with unconditional security over a standard, error-free communication medium. Various results, however, show that we can make use of noisy channels, where we can exploit errors in the communication to our advantage in order to implement OT in a secure fashion. First tested against standard primitives like the Binary Symmetric Channel, it has later been demonstrated how to build OT over a fair number of new noisy channels models proposed over the years. However, these models are usually derived from the BSC itself, and different sources of noise have been scarcely explored. In this paper we propose a new noisy channel primitive, called Binary Discretetime Delaying Channel. The aim is to model a realistic scenario in communication systems, while basing it on as few assumptions as possible. In particular, we make use of a rarely used error source, the delays in communication. We also provide a way to securely build OT over this new model in the semi-honest scenario, and then we add some robustness to the protocol, mitigating the influence of a cheating transmitter. The flexibility and generality of this new model may open the way for future implementation, especially in media where delays are a fundamental characteristic, as in the case of wireless communications.


Abstract Nodular amelanotic melanoma has been always a great challenge in dermatology. Because of lack of melanin pigment, tumors are diagnosed usually in advanced stage. Amelanotic melanoma can mimic basal cell carcinoma. Knowledge of typical dermoscopic structures helps to establish diagnosis and to plan surgery with appropriate safety margins. In amelanotic melanoma we can see typical vessels, white streaks or milky red globules on pink-reddish background. Vessels are typically thin and polymorphous in thick amelanotic melanoma. We had a case when vessels were polymorphous but thick. It can be confusing with nodular basal cell carcinoma where vessels are typically thick and arborizing. Nodular basal cell carcinoma is the most common form of basal cell carcinoma. Dermoscopy is a valuable tool for the diagnosis of basal cell carcinoma. Typical dermoscopic structures are arborizing vessels, possible sites of ulceration and/or pigmentation. We describe a case report of patient with typical dermoscopic structures seen in nodular basal cell carcinoma.


Current machine learning techniques for network-based intrusion detection cannot handle the evolving behavior of network traffic, requiring periodic model updates to be conducted. Besides requiring huge amounts of labeled network traffic to be provided, traditional model updates demand expressive computational costs. This paper proposes a new feasible model update procedure implemented in two steps. First, we use a Generative Adversarial Network (GAN) to augment the sampled network traffic. Next, we use the augmented dataset to perform model updates through a transfer learning-based approach. Thus, our model can decrease both the number of instances that must be labeled and the computational costs during model updates. Our experiments on a one-year dataset with over 8 TB of data show that literature techniques cannot handle changes in network traffic behavior. In contrast, the proposed model without updates improved true-positive rates by up to 25.6%. With monthly model updates, it requires only 14% of computational costs and 2.3% of instances to be provided.


Abstract The 1983 evaluation of A = 95 (83Lu03) has been updated using experimental decay and reaction data received by February 3, 1993.


Supernova remnants (SNRs) have emerged as one of the largest source classes in very-high-energy (VHE; E>0.1,TeV) astronomy. Many of the now known VHE gamma-ray emitting SNRs have been discovered by the H.E.S.S. imaging Cherenkov telescope array, thanks to its unique access to the inner galaxy. Statistically-significant emission of VHE gamma rays has now been detected from the direction of the supernova remnant G15.4+0.1. While the centroids of the H.E.S.S. source and the shell-type SNR are compatible, the VHE morphology suggests a center-dominated source at TeV energies, something which is at odds with the shell-like morphology observed at radio frequencies. This suggests that H.E.S.S. may be observing TeV emission from a previously unknown pulsar wind nebula (PWN) located within the boundaries of the radio shell. If this interpretation is correct, G15.4+0.1 would in fact be a composite SNR, the first case in which an SNR is identified as a composite on the basis of VHE gamma-ray observations. Archival data from MAGPIS gives exciting hints that there is radio emission from the central parts of the remnant, giving support to this hypothesis. Unfortunately, image artefacts from a nearby strong radio source produce considerable uncertainties in the radio analysis. Additional observations in both the radio and X-ray are needed to confirm the composite nature of G15.4+0.1 suggested by H.E.S.S.


Sound quality depends on cognitively processed features referenced to an assigned set of expectations. It describes the perception of suitability and desirability of a sound attached to a certain product. However, since experiences of electric vehicle technology and established expectations rarely exist, several questions remain unanswered. What are the references customers use to evaluate sound quality of electric vehicles? How to meet customers' needs without established targets? Is it possible to simply set sound quality standards, where customers will increasingly adapt to? Experiments and interviews are needed to answer reliably these questions. It is evident that successful sound design of electric vehicles depends on several aspects. Besides customer preferences, technology image, strategies of car manufacturers, economic and ecological factors, the social discussion of electric vehicle technology will contribute to the acceptance or rejection of sound design concepts. In fact, expectations are socially shaped and the impact of public discourse on expectations must be considered. The paper will present results gained in test drives, where subjects drove electric vehicles and commented different sound concepts. Moreover, the experimental results will be discussed from a broader contextual perspective.


Currently, over 16 million dementia caregivers in the US provide over 18 billion hours of care. As the number of persons living with dementia increases, so too will the number of family caregivers. Given the projected steady growth in caregivers and their health-related needs in caring for persons living with Alzheimer disease and related dementias, several initiatives are underway that focus on caregivers. One overlooked mechanism to meet caregiver needs is the National Institute on Aging's Alzheimer's Disease Research Centers (ADRCs). Through secondary analysis, we present a picture of dementia caregiving from the National Alzheimer's Coordinating Center's database and discuss a call to action for ADRCs to engage caregivers and further support the mission of the ADRC to advance the field of dementia research.


Objective: To evaluate the effectiveness of lidocaine gel in pain relief during endometrial sampling procedure (ESP).

Materials and Methods: A double-blinded randomized controlled trial was conducted at the gynecology clinic of Thammasat University Hospital between January and June 2020. Women aged over 35 years old with abnormal uterine bleeding were recruited. The participants were equally randomized assigned into two groups. The study and the control group received 3 mL of 2% lidocaine gel and lubricant gel locally applied at the cervix five minutes before performing ESP, respectively. The visual analog scale (VAS) was used to evaluate pain scores. Results were collected at five timeframes, insertion of a speculum, at the first, second, and third ESP, and five minutes post-procedure.

Results: One hundred and ten women, with 55 in each group, were eligible for randomization. Mean age of participants was 50 years old. Half of the cases (46/110) had complaint of irregular vaginal bleeding. Demographic characters of both groups were comparable. VAS at five timeframes in the study group and the control group were 19/23, 51/51, 56/60, 60/64, and 20/18, respectively, without statistical significance. The severe pain score was highest in the third ESP for both groups. Three cases of endometrial cancer were diagnosed. Ten percent (11/110) of tissue samples were inadequate for evaluation.

Conclusion: Application of lidocaine gel at the cervix could not effectively reduce pain during ESP.

Keywords: Pain; Endometrium sampling; Lidocaine gel


Melanoma is developed due to disturbances in the melanocytes of the skin cells. Every human skin color is defined by melanin, which is produced by melanocytes. Around the globe, the melanoma probability percentage age intervals are from 70 and older. Melanoma is a lethal form of cancer and can easily spread to other parts of the body. It needs to be detected and treated early to avoid mortality. Early diagnosis can be made by an automated diagnosis system to help clinicians for larger populations. In the proposed system, the input images are taken from Med Node, PH2, and HAM10000 Kaggle and given to the pre-trained architectures such as AlexNet, Vgg-16, ResNet50, Inception V3, and GoogleNet. The performance is analyzed using accuracy (AC), sensitivity (SE), specificity (SP), positive predictive value (PPV), and negative predictive value (NPV). Among all the architectures, InceptionV3 obtained the best accuracy of 97.1%, 97.2%, and 96.2% for the MedNode, PH2, and HAM10000 Kaggle datasets, respectively, in melanoma identification.


This paper centres on the question as to what constitutes "good policing"? Four approaches to defining good policing are identified; the objectives, professional ethics, generic competency and interactionist. It is argued that these are differentiated by the extent to which they concentrate on either instrumental and technical dimensions of policing or the social political impact of its outcomes. Through a detailed examination of one incident of routine policing, the authors argue that any analysis which separates technical questions about means from moral questions about ends will remain partial. Finally, it is argued that the development of good policing is a personal achievement on the part of officers and can only be systematically developed if the organisation creates the "ethical space" to allow officers to critically reflect on practice.


ABSTRACT Although students with disabilities are over-represented in the juvenile justice system and frequently receive poor educational services, few studies have examined strategies to increase compliance with student needs and individualized education programs. In this study, we conducted interviews with eight probation officers in the Advocacy Unit of a juvenile justice system in a large Midwestern city. We examined the advocacy strategies used by the probation officers as well as the barriers they faced in ensuring court-involved youth received appropriate educational supports. Advocacy strategies included: documentation, collaboration with other stakeholders, and assertive but not aggressive communication. Probation officers also mentioned more creative advocacy strategies. Barriers to effective advocacy included: poor working relationships with schools, older age of youth, and obstacles to parent involvement. We discuss implications for research and practice.


Graves' disease and thyroiditis are two common causes of hyperthyroidism in our clinical practice. Isotope scan is the test for differentiating Graves' disease from thyroiditis with thyrotoxicosis but not available widely in India [Figure 1]. In our cohort of consecutive 228 cases of Graves' disease and thyroiditis, we tried to compare the clinical and biochemical features at diagnosis. Our data favours a diagnosis of Graves' disease with positive family history, high Crooks Wayne's index, high free T4 and low ESR at the time of diagnosis. But these alone may not be sufficient as differentiating pointer between Graves' disease and thyroiditis with thyrotoxicosis.


This article presents a conveyor belt fire classification model that allows for the determination of the most effective firefighting strategy. In addition, the effect of belt design parameters on the fire classification was determined. A methodology that involves the use of numerical simulations and artificial neural networks was implemented. An approach previously proposed for modeling fires over conveyor belts was used. With the objective of obtaining some required modeling input parameter and verifying the capacity of this approach to get realistic results, computational fluid dynamics model calibration and validation were carried out using experimental test results available in the literature. Results indicated that scenarios with belt positions closer to the mine roof and greater tunnel heights require a higher longitudinal air velocity to be attacked directly. Furthermore, the belt fire classification model provided by the artificial neural network had an accuracy around 95% when test scenarios were classified.


Abstract : This report is concerned with a series of experiments in which the effects of manipulator restraints, i.e., load dynamics imposed on the operator, are central. The purposes of this investigation are to: Determine the load effects on the human operator's describing functions and performance measures for a representative variety of manipulator restraints and controlled elements. Provide inferential insight into the relative importance of limb position and output force senses in manual control.


Purpose - Existing literature about consumer perception has received substantial notice in the field of psychology. However, less is known about consumer perception of green marketing. To address t ...


In the drug industry, biopolymers play a key role in administering drugs to patients. The efficiency and activity of drug depends on its solubility-hence the need for an excellent hydrolytic decomposition of biopolymeric drug carriers. Biopolymers are natural polymers from living organisms. Human body contains many enzymes which help in metabolic activities. The effect of enzymes on effectiveness and efficacy of drugs have been studied. In this review, those studies have been analysed and presented critically with the aim of bringing to surface both positive and negative impacts.


Objective To observe the final adult height (FAH) outcome and influencing factors in Turner′s Syndrome(TS) children treated with recombinant human growth hormone ( rhGH ).Methods Thirty TS children treated with rhGH were compared with 16 TS children without rhGH treatment and were followed up to achieve their FAH.Comparisons were made regarding predicted adult height (PAH),height standard deviation score for chronological age( HtSDScA ),height SDS for BA( HtSDSRA ),and growth velocity ( GV ) between rhGH treatment and without treatment groups and between the onset and by the end of rhGH treatment group.The factors determining FAH were also evaluated.Results FAH in rhGH treatment group was obviously improved as compared with untreatment group[ ( 149.5±6.3 vs 142.4±5.2) cm,P<0.01 ].FAH in treatment group was positively correlated with height standard deviation score for chronological age ( Ht0 SDSCA ),Hto SDS for BA ( Hto SDSBA ),height age ( HA0 ) at preliminary diagnosis,and correlated with duration of rhGH therapy,duration of estrogen-free rhGH therapy,and PAH0SDS at preliminary diagnosis.Stepwise regression analysis indicated that duration of estrogen-free rhGH therapy and PAH0 SDS were the variables with the greatest identified influence on FAH (F =11.56 and F =86.91,P< 0.01 ).FAH in the 45,XO group was significantly different from the mosaicism group (45,XO/46,XX ) [ ( 147.2 ± 6.3 vs 153.3±6.4) cm,P =0.038].Conclusion rhGH treatment is efficacious in improving FAH of TS children,but a variability in the magnitude of the response to rhGH is recognized.Duration of estrogen-free rhGH therapy and PAH0SDS are the variables with the greatest identified influence on FAH,and karyotype may be one of the influence factors.rhGH treatment should be initiated as early as possible and sufficient course of estrogen-free rhGH therapy is needed to yield a satisfactory FAH.

Key words:
Recombinant human growth hormone;  Tumer′s syndrome;  Final adult height;  Influencing factors


A Latina teacherresearcher advocates for cultivating spaces of acompañamiento by centering student voices, stories, and knowledge through book clubs and young adult literature.


Polynucleotide phosphorylase synthesis is autocontrolled at a post‐transcriptional level in an RNase III‐dependent mechanism. RNase III cleaves a long stem–loop in the pnp leader, which triggers pnp mRNA instability, resulting in a decrease in the synthesis of polynucleotide phosphorylase. The staggered cleavage by RNase III removes the upper part of the stem–loop structure, creating a duplex with a short 3′ extension. Mutations or high temperatures, which destabilize the cleaved stem–loop, decrease expression of pnp, while mutations that stabilize the stem increase expression. We propose that the dangling 3′ end of the duplex created by RNase III constitutes a target for polynucleotide phosphorylase, which binds to and degrades the upstream half of this duplex, hence inducing pnp mRNA instability. Consistent with this interpretation, a pnp mRNA starting at the downstream RNase III processing site exhibits a very low level of expression, regardless of the presence of polynucleotide phosphorylase. Moreover, using an in vitro synthesized pnp leader transcript, it is shown that polynucleotide phosphorylase is able to digest the duplex formed after RNase III cleavage.