Search engines play a crucial role in the navigation through the vastness of the web. Today"s search engines do not just collect and index web pages, they also collect and mine information about their users. They store the queries, clicks, IP-addresses, and other information about the interactions with users in what is called a search log. In this paper, we analyze algorithms for publishing frequent keywords, queries, and clicks of a search log. We first show how methods that achieve variants of k-anonymity are vulnerable to active attacks. We then propose an algorithm ZEALOUS and show how to set its parameters to achieve probabilistic privacy. We also contrast our analysis of ZEALOUS with an analysis by Korolova et al. [17] that achieves in-distinguishability. Our paper concludes with a large experimental study using real applications where we compare ZEALOUS and previous work that achieves k-anonymity in search log publishing. Our results show that zealous yields comparable utility to k-anonymity while at the same time achieving much stronger privacy guarantees and also can be applied more generally to the problem of publishing frequent items or item sets. A topic of future work is the development of algorithms to release useful information about infrequent keywords, queries, and clicks in a search log while preserving user privacy.


93 strains of chicken pathogenic E.coli were isolated from illed chickens with different pathological changes from 32 districts and cities in Henan Province.The test of pathogenicity,biochemistry and serotype identification were also conducted.The results of serotyping shows that among the serotypes were identified as mainly O78?O1 and O2,the mean isolation percentage are 35.14%?18.92%?13.51%,respectively.There also shows that there are no relativity between the pathogenicity and the serotyping.


【Objective】To observe the changes of cytokines and renal function in elderly patients during gastric cancer surgery compared with young adults and investigate the relationship between perioperative inflammation and renal injury.【Methods】40 patients with elective surgery for gastric carcinoma under general anesthesia were divid-ed into two groups:group Ⅰ,patients aged 65 years or older(N=20),and group Ⅱ,younger than 60 years(N=20).Blood samples were analyzed for tumor necrosis factor-α(TNF-α),soluble TNF receptor-Ⅰ(sTNF-RⅠ),inter-leukin-6(IL-6),interleukin-10(IL-10)and urine for creatinine(Cr),β-N-acetyl-D-glucosaminidase(NAG),uri-nary α1-micro globulin(α1-MG),albumin(Alb)before general anesthesia induction(T0),1 h after incision(T1),on the first(T2),third(T3)and fifth day(T4)postoperatively.【Results】Plasma concentrations of TNF-α rose significant-ly at T1 and then returned to normal levels without difference between groups.Serum levels of sTNF-RⅠ rose signif-icantly from T1 to T4 without difference between groups.Interleukin-6(IL-6)at T2 and T3 in Group I were signifi-cantly higher than those in Group II(P 0.05).Serum concentrations of IL-10 were significantly raised at T1 and T2 in both groups with significantly higher in Group II(P 0.05).Urinary α1-MG/Cr and NAG/Cr in both groups in-creased significantly from T1 to T4(P 0.05),NAG/Cr in Group Ⅰ were significantly higher than those in Group Ⅱ during observation.Alb/Cr in Group Ⅰ rose significantly from T1 to T3(P 0.05),while Alb/Cr in Group Ⅱ returned to normal level at T3.【Conclusion】Compared with young adult patients,more serious postoperative renal tubule ep-ithelial cell injury in elderly during upper abdomen surgery may be due to more serious pro-inflammatory responses in the aged.


We describe the use of Google Earth during and after a large damaging earthquake that struck the central Japan coast on 16 July 2007 to collect and organize damage information and guide the reconnaissance activities. This software enabled greater real-time collaboration among scientists and engineers. After the field investigation, the Google Earth map is used as a final reporting product that was directly linked to the more traditional research report document. Finally, we analyze the use of the software within the context of a post-disaster reconnaissance investigation, and link it to student use of Google Earth in field situations.


The purpose of the study is the evaluation of the numerical accuracy of FIDAP (Fluid Dynamics Analysis Package). Accordingly, four test problems in laminar and turbulent incompressible flows are selected and the computational results of these problems compared with other numerical solutions and/or experimental data. These problems include: (1) 2-D laminar flow inside a wall-driven cavity; (2) 2-D laminar flow over a backward-facing step; (3) 2-D turbulent flow over a backward-facing step; and (4) 2-D turbulent flow through a turn-around duct.


Affordability is one important and widely accepted element of state and local debt policy. However, there is no well-established measure of affordability and no clear standard for making normative judgments about what amount of debt is affordable for a specific jurisdiction. This article suggests a six-step method for measuring affordability of state debt that provides a useful guideline for determining when a state may be entering a "danger zone" by having debt that exceeds norms of affordability.


BACKGROUND Nutrition is one of the fundamental needs of both patient and non-patient populations. General trends promote enteral feeding as a superior route, with the most common enteral access being the percutaneous endoscopic gastrostomy (PEG) as the first-line procedure, with surgical access including Witzel gastrostomy, Stamm Gastrostomy, Janeway gastrostomy (JG) as secondary means. AIM To describe cases and technique of laparoscopic Janeway gastrostomy (LJG) and perform a systematic review of the data. METHODS We successfully performed two LJG procedures, after which we conducted a literature review of all documented cases of LJG from 1991 to 2022. We surveyed these cases to show the efficacy of LJG and provide comparisons to other existing procedures with primary outcomes of operative time, complications, duration of gastrostomy use, and application settings. The data were then extracted and assessed on the basis of the Reference Citation Analysis (https://www.referencecitationanalysis.com/). RESULTS We presented two cases of LJG, detailing the simplicity and benefits of this technique. We subsequently identified 26 articles and 56 cases of LJG and extrapolated the data relating to our outcome measures. We could show the potential of LJG as a viable and preferred option in certain patient populations requiring enteral access, drawing reference to its favorable outcome profile and low complication rate. CONCLUSION The LJG is a simple, reproducible procedure with a favorable complication profile. By its technical ease and benefits relating to the gastric tube formed, we propose this procedure as a viable, favorable enteral access in patients with the need for permanent or palliative gastrostomy, those with neurologic disease, agitation or at high risk of gastrostomy dislodgement, or where PEG may be infeasible.


Korean Department of Police and Department of Justice co proposed ``forensic DNA data bank Act`` and sent it Korean Parliament on September, 2006. The purpose of this paper is to review and comment the draft bill from the perspective of informational Privacy. My position is balancing the need using DNA data bases and the need for some protection of personal privacy. Striking the right balance between too little protection for privacy to be preserved and too much protection for law enforcement to effectively function is very difficult and complex. In this paper the author uses OECD Guidelines on the Protection of Privacy and Trans border Flow of Personal Data(adopted in 1980)(from now on ``OECD Guidelines``) as a balancing tool. In 1996, South Korea became a member state of OECD. Even though domestic regulators are not bound these guidelines, the power of the guidelines lies in the substance of what they suggest and the expertise of their drafters. As such, these guidelines have offered legislature around the world a choice when creating laws affecting informational privacy. They are designed to aid in the creation of an appropriate balance between the necessity of processing, storing, and disseminating personal information and the individual`s need for informational privacy. In Part Ⅱ, the author comments the bill generally and roughly from the perspective of OECD guidelines. In Part Ⅲ, the author comments on several hard issues of the bill intensively from the perspective of OECD guidelines. In Part Ⅳ, the author comments on exclusively the issues of the consent of donors from the perspective of decisional privacy. In Part Ⅴ(conclusion), the author strongly suggests and proposes to prepare the Korean concept of genetic privacy.


In vitro antimicrobial and antioxidant activities of sequential bark extracts of Peltophorumpterocarpum Baker ex K. Heyne,was tested against four Gram negative, two Gram-positive bacteria and fivefungal isolates. Antioxidant profile was investigated using 2, 2-Diphenyl-1-picryl-hydrazyl and reductioncapability by ferric ion reducing antioxidant potentials method. Bark ethyl acetate extract showed significantactivity against B. subtilis and P. aruginosa (IZ 18.33 ± 0.33 mm and 18.33 ± 0.57 mm with MIC of 62.5 and31.25 μg/ml, respectively) similarly, higher antioxidant potentials with lower IC50value (5 μg/ml; %inhibition of 97.08 at 80 μg/ml), whereas in FRAP method, methanol extract (1463.33 ± 3.33 AAE/mg dwantioxidant potential) show better activity. Further, GC-MS analysis of the ethyl acetate extract confirmed33 compounds. The main identified constituent was 1,2-benzenedicarboxylic acid, bis(2-ethylhexyl) esterwith 48.9% availability.

http://www.envirobiotechjournals.com/AJMBES/vol 24 issue 2/AJ-37.pdf


Several immunological parameters were investigated on the lymphocytic component of eight persistent and seven hyperplastic thymuses, and of 10 thymomas from myasthenia gravis (MG) patients. As in the control thymus, the great majority of thymic lymphocytes of MG patients are T cells. A negligible B cell content was detected in thymomas and in MG thymuses with absent or rare lymph-follicles but a substantial B cell presence associated with significantly lower percentages of E-rosetting cells was found in all the hyperplastic thymuses with many germinal centers.I Lymphocytes from MG nonneoplastic thymuses and from six thymomas with moderate or predominant lymphocytic infiltrate were capable of forming stable-E rosettes (78.9 k 7.1 and 78.0 & 5.2, respectively), of binding peanut agglutinin (PNA) (71.2 5 10.1 and 67.3 k 8.6) and exhibiting receptors for the Fc portion of IgM (23.1 & 7.4 and 21.8 k 6.0) at percentages that were close to those found in the normal gland. On the other hand, lower numbers of stable-E rosetting cells (26.8 5 8.7), PNA positive cells (27.5 2 12.4), and remarkably higher percentages of cells with receptors for IgM (54.0 & 4.2) were displayed by the lymphocytic population from four thymomas with scant lymphocyte component.2 Similar, poor blastic responses to PHA were exhibited by cells from normal and MG nonneoplastic thymuses while lymphocytes from thymomas responded vigorously to phytomitogens. Moreover the highest responses were always shown by lymphocytes from tumors with a scant lymphocytic component. From these results the following conclusions can be drawn: The lymphocyte subsets, identified in MG nonneoplastic thymuses by surface markers techniques and by mitogen stimulation, did not significantly differ from those found in control glands, the only difference being a substantial B cell presence in MG hyperplastic thymuses with many germinal centers. The lymphocytes from thymomas with predominant lymphocyte infiltrate showed very close similarity with those from normal thymuses. Conversely, the immunological characteristics of lymphocytes from thymomas with scant lymphocyte component indicate that a more advanced maturative step is attained by these cells, as in the medulla of normal thymus gland, perhaps owing to a more intimate contact with the neoplastic epithelial component. The immunological similarities between thymoma and normal thymus lymphocytes strongly support an exclusively epithelial origin of thymomas. The lack of evidence for very prominent differences in surface markers expression and in blastic responses between thymocytes from normal subjects and MG patients, together with the well-known beneficial effect of thymectomy


The current study aimed to evaluate the physico-chemical, microbiological and organoleptic characteristics of proposed tuna (Thunnus thynnus) products during the storage under freezing conditions. Tuna products of burger, nuggets and fingers were prepared and stored at -18°C for six months. The above-mentioned characteristics were measured every two weeks as a time interval during the storage period. The moisture content significantly decreased over the storage time (3.11±0.83 g every two weeks). As a result, at the end of storage time (6 weeks), the loosing ratios in moisture content for burger, nuggets and fingers were 15.87, 16.03 and 15.84 (%), respectively. Heavy metals content in tuna was arranged in a descending order as iron> copper> lead> cadmium> mercury, with values being 27.7, 6.30, 2.035, 1.214, and 0.547 mg/kg fresh weight, respectively. There were no significant differences observed among the levels of the toxic metals (Hg, Pb and Cd) in raw tuna meat and its products. The results of microbiological analysis revealed that the total bacterial count and numbers of Salmonella sp. and E. coli were decreased over time under freezing condition. Except for firmness and gumminess, the texture characteristics of tuna products showed no significant changes during the storage period. The results concluded the stability and safety of tuna burger, nuggets and fingers under freezing conditions besides the high acceptability for these products between the consumers.


This paper addresses the form-meaning relation of multimodal communicative actions by means of a
grammar that combines verbal input with hand gestures. Unlike speech, gesture signals are
interpretable only through their semantic relation to the synchronous speech content. This relation
serves to resolve the incomplete meaning that is revealed by gestural form alone. We demonstrate
that by using standard linguistic methods, speech and gesture can be integrated in a constrained way
into a single derivation tree which maps to a uniform meaning representation.


Observations from the Rossi X-Ray Timing Explorer have shown the existence of high frequency quasiperiodic oscillations (HFQPOs) in the X-ray flux from accreting black hole binary systems. In at least two systems, these HFQPOs come in pairs with a 2:3 frequency commensurability. We propose a simple "hot spot" model to explain the position and amplitude of the HFQPO peaks. Using the exact geodesic equations for the Kerr metric, we calculate the trajectories of massive test particles, which are treated as isotropic, monochromatic emitters in their rest frames. Photons are traced from the accretion disk to a distant observer to produce timeand frequency-dependent images of the orbiting hot spot and background disk. The power spectrum of the X-ray light curve consists of multiple peaks at integral combinations of the black hole coordinate frequencies. In particular, if the radial frequency is one-third of the azimuthal frequency (as is the case near the inner-most stable circular orbit), beat frequencies appear in the power spectrum at two-thirds and four-thirds of the fundamental azimuthal orbital frequency, in agreement with observations. We also model the effects of shearing the hot spot in the disk, producing an arc of emission that also follows a geodesic orbit, as well as the effects of non-planar orbits that experience Lens-Thirring precession around the black hole axis. By varying the arc length, we are able to explain the different QPO features observed in "Type A" and "Type B" X-ray outbursts from XTE J1550-564. In the context of this model, the observed power spectra allow us to infer values for the black hole mass and angular momentum, and also constrain the parameters of the model, such as the hot spot size and luminosity. Subject headings: black hole physics – accretion disks – X-rays:binaries


In this paper, I analyze the joint design of capital requirements and fair value reporting rules for financial institutions with illiquid assets. I specifically examine how prudential regulation aimed at solving agency problems affects financial institutions' incentives to use Level 2 versus Level 3 fair value reporting, as well as financial stability. Crucially, Level 3 reporting allows financial institutions to use their private information, whereas Level 2 fair values are only measured with public information. Interestingly, my analysis shows regulators may leave to financial institutions the discretion to report illiquid assets at Level 2 or Level 3. Financial institutions then report at Level 3 only if they have good private information about the assets' quality. Moreover, prudential rules that only rely on Level 2 fair values may be efficient at solving agency problems within financial institutions but may also decrease financial stability. By contrast, prudential rules that leave to financial institutions the discretion to report illiquid assets at Level 2 or Level 3 while relaxing capital requirements may increase financial stability. This paper was accepted by Suraj Srinivasan, accounting. Funding: This work was supported by the H2020 European Research Council [Grant 669217]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2023.4692 .


Obesity and type 2 diabetes mellitus (T2DM) are risk factors for nonalcoholic fatty liver disease, including nonalcoholic steatohepatitis. This study assessed pegbelfermin (BMS‐986036), recombinant PEGylated human fibroblast growth factor 21 (FGF21), in patients with obesity and T2DM predisposed to fatty liver.


By processing the original data and modifying the initial condition of differential equations, an improved GM(1,1) model based on the modification of boundary condition is established and applied to the load forecasting of regional power network. The calculation results of actual examples show that the improved model can exponentially modify the forecasting values from generating sequences and original sequences, so the forecasting error can be decreased significantly and the forecasting accuracy can be improved.


The present study investigated the effect of cold rolling reduction on microstructure and mechanical properties of a 204C2 Cr–Mn austenitic stainless steel which contained 16%Cr, 2%Ni, 9%Mn and 0.083 %C). The 204C2 austenitic stainless steels were cold rolled at multifarious thickness reductions of 10%, 20%, 30%,40% and 50%, which were compared with the solution-treated one. Microstructure of them was investigated by means of optical microscopy, X-ray diffraction technique and scanning electron microscopy. For mechanical properties investigations, hardness and tensile tests were carried out. Results shows that the cold rolling reduction induced the martensitic transformation (γ→α ́) in the structure of the austenitic stainless steel. With the increase of the rolling reduction, the amount of strain-induced martensite increased gradually. Hardness, ultimate tensile strength and yield strength increased with the incremental rolling reduction in 204C2 stainless steels, while the elongation decreased. At the thickness reduction of 50%, the specimen obtained best strength and hardness. Hardness of 204C2 stain steel reached 679HV. Ultimate tensile strength reached 1721 MPa. Yield strength reached 1496 MPa.


In this paper, we investigate the problem of detecting and monitoring changes (abnormality) in molecular communication (MC), using the quickest change detection (QCD) schemes. The objective is to watch an environment using a sensor network and make decisions on the time and location of changes based on the received signals from sensors in the fusion center (FC). Such assumptions call for considering spatial and temporal correlations among sensors' transmitting signals. We use the framework of Partially Observable Markov Decision Processes (POMDPs) based on non-homogeneous Markov models. The metric in detection (stopping-time) scenario is to minimize the delay of announcing an abnormality occurrence from the real change time, in a two-hypothesis setting, subject to constraints on false alarm and missed identification probabilities. Since the optimum detector is very complicated, by utilizing a myopic policy, sub-optimum detectors with less complexity and acceptable performances are proposed. For monitoring scenario, the goal is to determine how the changes are spread in time, in a multi-hypothesis setting. Such goal asks for deciding on multiple changes in time, which is different from the stopping-time scenario. In the latter scenario, we decide only about whether one change has occurred or not, then we stop decision making. In the monitoring scenario, one optimum and two sub-optimum metrics are defined and their corresponding detectors are derived. In this scenario, the detectors make decisions only in the time slots that a reliable decision can be made. The defined metrics minimize the waiting-time, the time that the detector does not make decision about any of the hypotheses due to lack of assurance, subject to constraints on false alarm and missed identification probabilities. In both scenarios, we mathematically model the system and evaluate the performance of the proposed detectors. For performance evaluation, we consider modeling a previously reported system of tumor growth in a tissue. The results confirm out-performance of the proposed detectors in comparison with existing ones.


Based on the existing assessment theory and model, a newt campus security model is structured. Then use this model to evaluate campus security of four universities in Hebei province. The results showed that the model, based on grey cluster, not only could confirm the quality degree of every evaluation object but also could assess more objects at the same time and make comparison between different evaluation objects for campus security evaluation. That is mean grey cluster is feasible and instructive.


One bis-amide bis-phenoxi N2O2  ligand was obtained from the 2:1 molar reaction of phenyl salicylate and the diamine, 1,3-Diamino-2-2-dimethylpropane, to yield H4L. The ligand has been characterised by elemental analysis, IR, and 1H 13C  NMR spectroscopies, mass spectrometry (ES) and Xray  difraction.


Sutong and Bi feiyu are good at describing women's fate.There are both similarities and differences in their choosing the characters' conflict mode,describing the good and evil of the human nature,arranging the characters' stage and in the feeling and attitudes guiding their literary creation.By analyzing these aspects,we can find some features of the artistic selection and aesthetic preference of women characters' creation in new stage's novels


The memristor, a circuit element, was first presented by Leon Chua in 1971. The physical implementation of the memristor was created by scientists at HP Labs in 2008 and the coupled variable resistor model was proposed. Here we show a SPICE model for such a memristor using dependent voltage sources. The model is validated by simulating simple circuits and comparing with the expected results. The proposed model makes it possible to design and simulate memristor circuits using SPICE. We simulate two circuits, a low pass filter in which a memristor is in series with a resistor and an integrator circuit with operational amplifier. The results are compared with inductor circuits in which a memristor is replaced by an inductor. The comparison shows that a memristor is acting like an inductor under certain conditions. Since the memristor has great performance in terms of power dissipation and with its nanometer size there might be a possible application of the memristor to be used as an inductor.


Abstract Classical broad-band photometry can provide direct comparisons of star clusters both with each other and with theoretical models of stellar evolution. The confidence with which conclusions can be drawn is often limited by the accuracy of the measurements. The present work is part of a long-term attempt to improve photometric calibrations.


Foreword: It's all about the people, Acknowledgements - Part I: Incite - It may come as a surprise: Successful change, management is mainly a matter of letting it happen by Paul J. Kohtes - Accept change as a constant state - Dismantle obstacles - Get the current flowing again - Find your identity and change it constantly - Less method, more personality - Outlook.- The human factor in change processes: Success factors from a sociopsychological point of view by Marit Gerkhardt, Dieter Frey and Peter Fischer - Implementation strategies: Top-down or bottom-up? - Attitude patterns of the affected staff Causes and forms of resistance - Twelve success factors in change processes - Conclusion. - Accelerated change dynamics within the healthcare industry: Just a trend, or is there more to it? by Markus Pickel - High level of change dynamics within the healthcare industry - Why are change programmes more in demand today than ever before? - Portfolio - Process - People: The trinity of speed in change - A digression concerning the real power of corporate culture - Corporate communications as the mediator of change - Change communication as a key success factor for change - Structural prerequisites for change communication - Summary: Speed as a basis for change.- The power of ideas - Reputation management and successful change by Robert Wreschniok - Reputation, an acquirable good - Reputation management in change processes: Laws and regulations - An example from the financial sector - Conclusion. - Change management in alliances by Theresia Theurl and Eric Meyer - Building and managing alliances - The benchmark case: Continuous change - Change management in alliances - Considering the specifics - How to overcome the communication problem - How to overcome the competence problem - The role of contracts - Conclusion. - Part II: Insight - Winning people's hearts and minds by Katrin Schwabe - The power of dialogue - Tools for successful dialogue - Cascading waves- 'Time to people' - Town hall meetings - Keeping stakeholders in the loop - CEO breakfast - Forming an alliance - Ambassador platforms - Supporting special agents - Kick-off events - Enabling many-to-many conversations - Business simulations - Practice 'how to fly' before taking-off - Engagement throughout - Impact of change communication - Start talking.- Use of multipliers in change communication: How credible personal communication can make change effective by Eike Wagner - What is the multiplier approach and what is it not? - Where does it apply in practice? - What is the role of multipliers? - How much time do multipliers need? - How to choose multipliers? - How to prepare multipliers? - How to integrate multipliers into communication activities? - How to measure the success of the multiplier approach? - Benefits - Lessons learned. - Why engagement matters - From command and control to collective learning via social software by Sabine Stecher - Engagement in change processes - Engagement - Ideology or a measurable strategy for success? - Level of engagement - Engagement and communication - Social software as an engagement tool in change processes - Social software as a work platform - Paradigm shift in corporate communication - 2.0 = Too much effort and 0 results? - Social software in change communication - Chances and risks of social software in change communication - Cultural bridges - Conclusion. - The importance and use of analyses in change management by Rainer Lang and Julia Zangls - Change controlling - Demands on the execution of change controlling - Staff and change controlling - Areas of application for change controlling - Evaluation at staff level - Quantitative and qualitative methods - Feedback systems - The ratio-oriented approach: The Change Scorecard - Improving the prospects of success in change - 'Change Explorer' - Outlook . - Part III: Inside - The quiet transformation of an ugly duckling:


This study aimed to analyse superior squash rackets players' preference of racket shape and understanding of string elasticity. The conclusion analysed from the results of this study is as followed. Firstly, it shows high tendencies that female, young and short experienced players prefer 'Open Throat Head', while male, old and long experienced players prefer 'Small Round Head'. Secondly, most of players prefer middle rate string elasticity of 28~31 pounds and classic pattern string for easy control for they consider 'control' important as a string 'character. Thirdiy, old players understand highly of string tension, while young players understand highly of string length and power. In case of short experienced players, it shows that they understand string length and power highly.


The semantic and morphological activities of the terms pope , bishop and priest show uneven distribution in time. The Oxford English Dictionary (OED) dating of the first occurrences of semasiological and onomasiological developments related to these terms points to their increased activity in the period 1550–1700. This paper aims to explain the motivation of these processes, viewing them in the context of historical developments. The corpus consists of comic drama texts available from the Literature Online (LION) database. The relevant texts give evidence that semasiology and onomasiology overlap, being governed by the same patterns of motivation. The linguistic processes accounted for in the article are closely related to the social and political events of the post-Reformation period in England.


Cigarette smoke is an environmental risk factor for COPD and Lung cancer, leading causes of morbidity and mortality worldwide. In cancer, enhancer of zeste homolog 2 (EZH2) silenced disabled homolog 2 interacting protein gene (DAB2IP) (tumor-suppressor gene) bytri-methylation of lysine 27 on histone H3 (H3K27me3). We studied EZH2 and DAB2IP expression in airway epithelial cells from COPD patients and their potential involvement in the progression of COPD toward lung cancer. We assessed EZH2 and DAB2IPimmunoreactivity in bronchial epithelial cells from surgical specimens of COPD patients and healthy control subjects (HC) by immunohistochemistry. Bronchial epithelial cell line (16HBE), primary human bronchial epithelial cells (pHBE), lung cancer cell line (A549 and H292) were long term exposed to cigarette smoke extract (CSE) to study EZH2, DAB2IP and H3K27me3 expression and cell apoptosis. GSK343 (a selective inhibitor of EZH2) effect was tested on DAB2IP and H3K27me3 expression as well on cell apoptosis. DAB2IP immunoreactivity was significantly lower while EZH2 immunoreactivity was significantly higher in bronchial epithelium ( positive cells/mm 2 ) from COPD patients compared to bronchial epithelium from HC subjects. CSE treatment decreased DAB2IP while increased EZH2 and H3K27me3expression in 16HBE, pHBE, A549 and H292. Furthermore, GSK343 increased DAB2IP expression and cell apoptosis while decreased H3K27me3 in 16HBE, pHBE, A549 and H292 treated with CSE. Smoking habits generate a DAB2IP/EZH2 genes imbalance by H3K27me3 in bronchial epithelial cells from COPD patients, promoting defects in the apoptosis mechanism implicated in lung cancerogenesis.


COBOL Programs for Libraries. By WILLIAM J. KURMEY. Metuchen, N.J.: Scarecrow Press, 1990. Pp. xii+432. $49.50. ISBN 0-8108-2329-2. The Concise Oxford Dictionary. Edited by R. E. ALLEN. New York: Oxford University Press, 1990. Pp. xxxix+ 1454. $27.95. ISBN 0-19-861200-1. The Electronic Campus: An Information Strategy. Edited by LYNNE J. BRINDLEY. Library and Information Research Report, 73. Proceedings of a conference held on October 28-30, 1988, at Banbury. Wetherby, West Yorkshire: British Library Board, 1989. Pp. xiv+ 138. $45.00. ISBN 0-7123-3187-5.


The sticking coefficient, S, of CO on clean and K-, 0and H-modified Pt(ll1) surfaces has been measured directly using a simple kinetic uptake method, as a function of CO and modifier coverage and surface temperature. A simple method is also introduced to determine the ~erage-dependent desorption energy from these measurement without the need to know the pre-exponential factor or desorption order for those systems where S is only a function of coverage or only weakly dependent on temperature. The initiai sticking coefficient of CO on clean Pt(lll) is 0.9 and is independent of substrate temperature. The major influence of adsorbed K on the initial sticking coefficient of CO on Pt(ll1) at 320 K is site blocking, and the magnitude of this effect correlates well with the size of the adsorbed K ion or atom. The shape of S as a function of CO coverage for low K coverages in the ionic regime is similar to that of CO on clean Pt(ll1). A dramatic change occurs for K coverages near or greater than 0.24 ML, where S passes through a maximum at about f of the saturation CO coverage and coincident CO and K desorption is observed. This behavior of S, which has not been seen before, can be fit quite adequately by a simple model that incorporates the reduced site blocking effects of K due to the CO-induced transition of K from a metallic neutral to an ionic state and the accompanying size change of K atoms. These results are best described by a coverage-dependent alkali-CO interaction. In additional studies, we find that adsorption of 0.25 ML 0 on Pttlll) has no effect on S for low CO coverages at 100 K, and only the saturation CO coverage is reduced from 0.59 to 0.31 ML. In contrast, adsorbed H reduces not only the CO saturation coverage but also S even at low CO coverages.


The acoustic resonance frequency and amplitude of spherical sintered polycrystalline specimens of ${\mathrm{BaPb}}_{1\mathrm{\ensuremath{-}}\mathrm{x}}$${\mathrm{Bi}}_{\mathrm{x}}$${\mathrm{O}}_{3}$ (x=0.20 and 0.25) were measured as a function of temperature (300--4.2 K) and external magnetic field (0--5 T). The resonance amplitude was found to be dependent on the magnetic field and temperature; it changed drastically at the second critical magnetic field and at the critical temperature of the normal-superconducting transition. This effect is interpreted in terms of a model in which the electron-phonon coupling of the thermal phonons play an essential role in determining the amplitude of the resonance.


In order to improve the cycle stability of the La-Mg-Ni system (PuNi{sub 3}-type) hydrogen storage alloy, Ni in the alloy was partly substituted by Cu. Hydrogen storage alloys La{sub 0.7}Mg{sub 0.3}Ni{sub 2.55-x}Co{sub 0.45}Cu {sub x} (x = 0, 0.1, 0.2, 0.3, 0.4) were prepared by casting and rapid quenching. The effects of substituting Ni with Cu and the quenching rate on the microstructures and the cycle stability of the as-cast and quenched alloys were investigated in detail. The results obtained by X-ray diffraction show that the as-cast and quenched alloys have a multiphase structure, including the (La, Mg)Ni{sub 3} phase, the LaNi{sub 5} phase and the LaNi{sub 2} phase, and the amount of the LaNi{sub 2} phase increased with the increase of the Cu content. The substitution and rapid quenching have an inappreciable influence on the phase compositions of the alloys, but both obviously changed the phase abundances of the alloys. The results derived by transmission electron microscopy confirm that the substitution of Cu for Ni is favourable for the formation of an amorphous phase in the as-quenched alloys. The results obtained by the electrochemical measurement indicate that substituting Ni with Cu improved the cycle stability. When the Cu contentmore » increases from 0 to 0.4, the cycle lives of the as-cast and rapidly solidified alloys increased from 72 cycles to 88 cycles and from 100 cycles to 122 cycles, respectively.« less


The review presents the progress of the experiment study on the anti-aging function of tonic qi-blood Chinese drug in immune organ、T cell-mediated immunity、phagocytolytic immunity、erythrocytic immunity and humoral immunity.In recent years,we discover from the experiment that tonic qi-blood Traditional Chinese Medicine is beneficial for our immunity and anti-aging.


A variant in the PRDM16 locus has been correlated with QRS duration in an electrocardiogram genomewide association study, and the deletion of PRDM16 has been implicated as a causal factor of the dilated cardiomyopathy that is linked to 1p36 deletion syndrome. We aimed to determine how a null mutation of Prdm16 affects cardiac function and study the underlying mechanism of the resulting phenotype in an appropriate mouse model. We used cardiac-specific Prdm16 conditional knockout mice to examine cardiac function by electrocardiography. QRS duration and QTc interval increased significantly in cardiac-specific Prdm16 knockout animals compared with wild-type mice. Further, we assessed cardiomyopathy-associated features by trichrome staining, densitometry, and hydroxyproline assay. Prdm16-null hearts showed greater fibrosis and cardiomyocyte hypertrophy. By quantitative real-time PCR, Prdm16-null hearts upregulated extracellular matrix-related genes (Ctgf, Timp1) and a-smooth muscle actin (Acta2), a myofibroblast marker. Moreover, TGF-b signaling was activated in Prdm16-null hearts, as evidenced by increased Tgfb1-3 transcript levels and phosphorylated Smad2. However, the inhibition of TGF-b receptor did not reverse the aberrations in conduction in cardiac-specific Prdm16 knockout mice. To determine the underlying mechanisms, we performed RNA-seq using mouse left ventricular tissue. By functional analysis, Prdm16-null hearts experienced dysregulated expression of ion channel genes, including Kcne1, Scn5a, Cacna1h, and Cacna2d2. Mice with Prdm16-null hearts develop abnormalities in cardiac conduction and cardiomyopathy-associated phenotypes, including fibrosis and cellular hypertrophy. Further, the RNA-seq findings suggest that impairments in ion homeostasis (Ca2+, K+, and Na+) may at least partially underlie the abnormal conduction in cardiac-specific Prdm16 knockout mice.


The Council of State Governments argues that police should be better trained to deal with mentally ill offenders. Increased funding is being requested in Congress to support educational programs for law enforcement.


Fulminant septicemia caused by Bacillus cereus following reduced-intensity umbilical cord blood transplantation Haematologica 2005; 90:(2)e13-e14 L Le et tt te er r t to o t th he e E Ed di it to or r Bacillus cereus is a saprophyte that is prevalent in the environment, and is generally considered to be a weak pathogen. Identification of this organism in clinical cultures is assumed to represent contamination; 1 however, it occasionally causes serious infection in immunocompro-mised patients. 2 This organism produces extracellular toxins including phospholipase C, proteases, hemolysins, and enterotoxins, 3 which damage some vital organs. Patients with acute leukemia are particularly susceptible to bacteremia resulting from B. cereus. 2,4,5 We report clinical courses of a patient who developed fatal B. cereus sep-ticemia following reduced-intensity cord blood trans-plantation (RI-CBT). A 25-year-old man with chemore-fractory T-cell acute lymphoblastic leukemia was referred to our hospital in July 2003. He had received multiple courses of chemotherapy and autologous peripheral blood stem-cell transplantation. Physical examination revealed generalized lymphadenopathy and high-grade fever, but no signs of infection. High-dose methotrexate was initiated at 2 g/m 2 for 2 days; however, lym-phadenopathy recurred with fever, and prophylactic antibiotics including third-generation cephalosporins, ciprofloxacin and carbapenems were administered. He had not undergone rachicentesis. After providing written informed consent, he elected to undergo RI-CBT in August 2003. While surveillance culture was not obtained before transplantation, pretransplant evaluations failed to show any evidence of active infections. Acyclovir 600 mg/day, ciprofloxacin 600 mg/day, and flu-conazole 100 mg/day were administered orally as pro-phylaxis for infection. Preparative regimen comprised 25 mg/kg of fludarabine for 6 days, 4 mg/kg of busulfan for 2 days and 4 Gy total body irradiation (TBI). Prophylaxis for graft-versus-host-disease was oral cyclosporin 6 mg/kg/day. During the preparative regimen, neutrophil counts remained <0.×10 9 /L, but his clinical course was uneventful except for persistent low-grade fevers and mild nausea. We speculated that fever and gastrointesti-nal symptoms could be attributed to residual leukemic cells and regimen-related toxicities. He was transfused two antigen-mismatched cord blood containing 2.2× 10 7 /kg mononuclear cells. On day 1, he developed high-grade fever. While he remained alert, physical examination revealed nuchal rigidity and hypesthesia in the right lower extremity. Blood pressure decreased to 80 mmHg. Septic shock with probable meningeal involvement was diagnosed. Blood examination showed normal functions of the liver and kidney. Hydration and intravenous administration of cefepime, vancomycin and tobramycin were initiated. Over the …


INTRODUCTION. The therapeutic strategies for managing patients with comorbid conditions, such as arterial hypertension (AH) and prediabetes, are widely adopting non-drug methods along with the recommended medications.
AIM. To evaluate the effect on fat distribution and humoral status of sulfide balneotherapy in the conditions of the experiment on white rats and clinical study of AH and prediabetes patients.
MATERIAL AND METHODS. The study was of a clinical and experimental nature and consisted of 2 phases – experimental and clinical. The experimental study was carried out on obese, non-pedigreed white rats. Animals were exposed to sulfide baths and a combination of sulfide applications and baths. In the clinical phase of the study, patients with AH and prediabetes were included. All patients included in the present study received standardised drug therapy according to clinical guidelines, and patients in the observation group additionally received combined sulphide balneotherapy (Suksun lake sulphide applications and baths) for 14 days. The study program included assessment of weight, waist circumference (WC), body mass index (BMI), assessment of serum concentrations of vascular endothelial growth factor (VEGF); tissue growth factor (TGF b), insulin and leptin, as well as determination of epicardial fat thickness (EFT).
RESULTS AND DISCUSSION. The experimental conditions revealed lipolysis in adipocytes (omentum), as well as an increase in the number of hemocapillaries in all areas of the heart and the growth of CD34 expression. The results of the clinical stage of the study suggest redistribution of fat depots against the background of sulfide balneotherapy. There were no statistically significant differences in weight and BMI in the dynamics, but there was a significant decrease in OT and TEF in the group of patients who received balneotherapy, who also had a significant decrease in HEFR concentration, leptin and an increase in TEFR beta 1.
CONCLUSION. The presence of lipolytic, regenerative and adipokine-regulating effects of sulfide balneotherapy was demonstrated in the experiment and clinical study.


The aim of this paper to develop a theory for generic representation of 2-D shape, where structural descriptions are derived from the shocks (singularities) of a curve evolution process, acting on bounding contours. The shocks are organized into a directed, acyclic shock graph and complexity is managed by attending to the most significant (central) shape components first. The space of all such graphs is highly structured and can be characterized by the rules of a shock graph grammar which permits a reduction of a shock graph to a unique rooted shock tree. A novel tree matching algorithm which finds the best set of corresponding nodes between two shock trees in polynomial time.


Our objective in this essay is to present an analysis on the behaviour of the woman as an important reference in social transformation. We take into consideration some of the social and scientific characteristics of post moderntiy in order to be capable of verifying the relationship between culture, discourse and society. We make an analysis of the conquests of the woman while seeking to establish what the positive and negative consequences of this were so that she could face the social reality and how this was represented in discourse. To this end, we relate violence against the woman in the chronicle "Cordel da mulher gaieira e do seu marido machao" , of Affonso Romano de Sant'Anna, with the aim of showing the banality of "machismo" as the important presence in the relationship of man and woman. It is worth pointing out, that in the analysis made, there is significance in the relationship and role between the social characteristics and their literary representation.


The Actinide Source Term represents the quantity of actinides that could be mobilized within WIPP brines and could migrate with the brines away from the disposal room vicinity. This document presents the various proposed methods for estimating this source term, with a particular focus on defining these methods and evaluating the defensibility of the models for mobile actinide concentrations. The conclusions reached in this document are: the 92 PA {open_quotes}expert panel{close_quotes} model for mobile actinide concentrations is not defensible; and, although it is extremely conservative, the {open_quotes}inventory limits{close_quotes} model is the only existing defensible model for the actinide source term. The model effort in progress, {open_quotes}chemical modeling of mobile actinide concentrations{close_quotes}, supported by a laboratory effort that is also in progress, is designed to provide a reasonable description of the system and be scientifically realistic and supplant the {open_quotes}Inventory limits{close_quotes} model.


A novel phosphorus-containing epoxy resin was synthesized by the reaction of DOPO(9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide) and the diglycidyl ether of bisphenol A.The thermostability and flame retardancy after water immersion of phosphorus-containing epoxy resin were characterized by thermogravimetry analysis,limiting oxygen index test and UL-94 vertical combustion test.Test results showed that the intrinsically flame-retardant phosphorus-containing epoxy resin had better thermostability and more persistent flame retardancy,when compared with the phosphate-containing cases.


Introduction: CPX-351 is a liposomal formulation of cytarabine and daunorubicin encapsulated at a fixed 5:1 molar ratio. It is highly effective in patients with high-risk acute myeloid leukemia (AML). This study evaluated the impact of CPX-351 (100 units/m2) on cardiac repolarization.

Methods: This open-label, Phase II, pharmacokinetic (PK) and pharmacodynamic (PD) study entered AML and acute lymphocytic leukemia (ALL) patients with good risk hepatic function (Child-Pugh scores <7), and normal cardiac function (LVEF≥50%, QTcF<470 ms). Cardiac repolarization changes were assessed using conventional ECG and Holter monitor recordings. PK was assessed during the first 21 days for total cytarabine, daunorubicin, Ara-U and daunorubicinol. The relationship between CPX-351 PK, QTcF, and renal function using the equation to calculate the estimated glomerular filtration rate (eGFR) was evaluated.

Results: Twenty-six patients entered the study and 21 were evaluable for QT interval change from baseline. Evidence that CPX-351 prolongs the QTcF interval was not observed. The largest absolute and mean change from time-matched baseline was 12.56 and 8.03 ms, respectively (Day 1, hour 4). Mean QTcF change on Day 5 was unchanged from baseline. QTcF intervals >480 ms were never observed and no consistent QTcF intervals >450 ms were noted. Absolute QTcF increases between 30 and 60 ms were present in 4 of 25 patients and no changes >60 ms were observed. CPX-351 plasma concentration vs. time curves for day 1 and 5 exhibited a volume of distribution approximately equal to the plasma volume with prolonged single-exponential elimination half-lives for cytarabine and daunorubicin of ≥24 hours. The PK of CPX-351 was independent of renal function. Patients with moderately impaired (eGFR=30-59 mL/min/1.73m2) renal function exhibited similar drug exposure as those with mild and normal renal function.

| Analyte | Renal Function | | Cmax (ng/mL) | AUClast (ng*hr/mL) | AUCinf (ng*hr/mL) | T1/2 (hr) |
| -------------- | -------------- | ----- | ------------ | ------------------ | ----------------- | --------- |
| Cytarabine | Normal (n=3) | Mean | 59333 | 2893146 | 2902641 | 42.5 |
| %CV | 28.7 | 68.8 | 69 | 34.1 |
| Mild (n=7) | Mean | 58071 | 3599512 | 3606695 | 41.0 |
| %CV | 31.9 | 52.4 | 52.4 | 21.8 |
| Moderate (n=3) | Mean | 57333 | 3149303 | 3156738 | 38.0 |
| %CV | 46.6 | 50.7 | 50.6 | 21.9 |
| Daunorubicin | Normal (n=3) | Mean | 25967 | 754646 | 870861 | 24.9 |
| %CV | 23.1 | 63 | 65.3 | 56.0 |
| Mild (n=7) | Mean | 28686 | 865034 | 1021420 | 30.5 |
| %CV | 43.9 | 43.5 | 43.6 | 25.3 |
| Moderate (n=3) | Mean | 21933 | 671542 | 814732 | 35.4 |
| %CV | 50.9 | 35.9 | 33.5 | 31.2 |

Table 1.
Impact of renal function impairment on Day 5 CPX-351 PK parameters (mean, %CV):

Table 2 summarizes response and transplant outcomes. One of two ALL patients achieved CR and was transplanted. Among AML patients there were 7 CR and 2 CRi of which three went on to transplant. An additional four patients became morphologically leukemia free (MLF) and were transplanted before full documentation of CR was achieved. A large majority of patients given first-line treatment with CPX-351 responded or became suitable for transplant (10/13, 77%).

| Diagnosis | n | Response CR/CRi | Transplanted in CR/CRi | Induced MLF and Transplanted | No Response |
| ---------------------- | -- | ---------------------- | ---------------------- | ---------------------------- | ----------- |
| ALL-Relapsed | 2 | 1/0 | 1/0 | | 1 |
| AML-First Line de novo | 8 | 5/0 | | 1 | 2 |
| AML-First Line sAML | 5 | 1/2 | 1/1 | 1 | 1 |
| AML-Salvage | 11 | 1/0 | 1/0 | 2 | 8 |

Table 2.
206 Study Efficacy

Conclusions: Clinically relevant prolongation of QTcF is not a feature of CPX-351 treatment. CPX-351 exposure was independent of renal function, indicating no need for dose adjustment when renal function is impaired. The high rate of complete remission and referral for transplant corroborate the high level of efficacy observed in earlier studies with CPX-351.

Disclosures Stuart: Sunesis: Honoraria, Other: Advisory Board, Research Funding; Astellas Pharma, Inc: Research Funding. Michaelis: Incyte: Membership on an entity's Board of Directors or advisory committees; CTI Biopharma: Membership on an entity's Board of Directors or advisory committees; Wyeth: Membership on an entity's Board of Directors or advisory committees; Pfizer: Equity Ownership. Pentikis: Celator Pharmaceuticals: Consultancy. Alvarez: Celator Pharmaceuticals, Inc.: Employment, Equity Ownership. Mayer: Celator Pharmaceuticals, Inc.: Employment, Equity Ownership. Louie: Celator Pharmaceuticals, Inc.: Employment, Equity Ownership.


Moderate Resolution Imaging Spectroradiometer (MODIS) can monitor precipitable water vapor (PWV) with high accuracy and large scales over land and ocean, using both near-infrared (nIR) bands and traditional IR bands. The MODIS nIR PWV is only available during daytime, which can be retrieved at 1×1km spatial resolution with high accuracy, while the MODIS IR PWV can be obtained during both the day and night time with a lower spatial resolution (5×5km), but is less accurate than the nIR PWV. In this paper, the performances of MODIS water vapor products at IR and nIR bands are evaluated by comparing with ground continuous GPSobservations. Results show that the traditional linear regression analysis is not the best choice to calibrate the MODIS PWV from the IR band. A new calibration model is being developed for the MODIS IR water vapor product using the IGS and radiosonde observations within the MODIS image coverage, and calibrated results are presented and assessed.


An evacuated photocell including a pair of planar interdigitated electrodes fabricated on a sapphire substrate is proposed. Photocurrent in the photocell was found to be originated from both a photoemission effect on the gold cathode and an internal photoelectric effect in the sapphire substrate. Because of the robust nature of the sapphire substrate and the gold electrodes, the photocell reliably tolerated more than 105 shots of fluorine laser pulses as strong as 0.13 J/cm2/pulse on the 7×7 mm2 active area. The photocell was successfully employed for measuring the pulse shapes of F2 laser light with a temporal resolution shorter than 6 ns.


ABSTRACT This study was designed to investigate the formation of patrons' repurchase intentions of a luxury hotel restaurant product by considering the impact of image congruence, quality, and satisfaction. This research also examined if such decision formation differs between first-timers and repeaters and tested the direction of causality between quality and satisfaction. Results indicate that our model sufficiently accounted for the prominent relationships among image congruence, satisfaction, and repurchase intention. Overall, our empirical findings provide both industry practitioners and researchers with a deeper understanding of patrons' decision-making process for repurchasing the luxury hotel restaurant product.


5047 Background: NKTR-102, a topoisomerase-I inhibitor-polymer conjugate with markedly reduced peak concentrations and a continuous concentration profile, demonstrated broad antitumor activity per RECIST in a phase I study. The original phase 2 study in platinum-resistant/refractory ovarian cancer showed a 21% confirmed objective response rate (ORR) (RECIST; Vergote, ASCO 2010).

METHODS
71 pts with platinum resistant/refractory ovarian cancer (PROC) were originally randomized to NKTR-102 IV at a dose of 145 mg/m2 q14d vs. q21d. In addition to being resistant/refractory to platinum, 33 pts in this analysis (16/q14d; 17/q21d) had also progressed on prior PLD. 6 of these 33 pts were platinum-refractory (progression within 28 days of last platinum dose). Eligible pts had ECOG PS 0-1, adequate renal, hepatic, and marrow function. The primary endpoint was ORR per RECIST; secondary endpoints included PFS, OS and safety.

RESULTS
For the 33 PROC pts pre-treated with PLD, median age was 59; ECOG PS 0/1 was 46%/54%; median number of prior cancer treatments was 4, with 2 of the treatments being platin-based. All but 2 pts received prior taxanes. 58% had received prior gemcitabine. Median platinum-free interval after prior platin-based regimen was 2.9 months. Confirmed ORR equaled 20%, 21%, and 21% for the q14d, q21d, and all pts combined, respectively. For all pts combined, median PFS was 5.5 months and median OS was 14.0 months. Common related Grade ≥ 3 toxicities (q14d/q21d) were diarrhea (31%/18%), nausea (31%/6%), hypokalemia (38%/0%), dehydration (19%/6%), fatigue (6%/18%) and vomiting (25%/0%). In contrast to other commonly used agents in PROC, NKTR-102 did not show clinically significant myelosuppression, neuropathy or alopecia.

CONCLUSIONS
NKTR-102 demonstrated clinically significant activity (confirmed ORR by RECIST of 21%) as a single agent in pts with heavily pretreated PROC who have also failed prior PLD. This study is being expanded to enroll an additional 50 pts with PROC having progressed on prior PLD. All pts are now receiving NKTR-102 on the q21d regimen due to the better toxicity profile.(Vergote, ASCO 2010).


In this paper, an improved wavelet threshold denoising with combined translation invariance(TI)method is adopted to remove noises existed in the bio-chemical spectrum. Meanwhile, a novel wavelet threshold function and an optimal threshold determination algorithm are proposed. The new function is continuous and high-order derivable, it can overcome the vibration phenomena generated by the classical threshold function and decrease the error of reconstructed spectrum. So, it is superior to the frequency-domain filtering methods, the soft- and hard-threshold function proposed by D.L. Donoho and the semisoft-threshold function proposed by Gao, etc. The experimental results show that the improved TI wavelet threshold(TI-WT) denoising method can availably eliminate the Pseudo-Gibbs phenomena generated by the traditional wavelet thresholding method. At the same time, the improved wavelet threshold function and the TI-WT method present lower root mean-square-error (RMSE) and higher signal-to-noise ratio(SNR) than the frequency-domain filtering, classical soft and hard-threshold denoising The SNR increasing from 17.3200 to 32.5609, the RMSE decreasing from 4.0244 to 0.6257. Otherwise, The improved denoising method not only makes the spectrum smooth, but also effectively preserves the edge characteristics of the original spectrum.


The working memory is a set of processes that allows us to keep and process information in a short period of time, to do cognitive tasks such as reading comprehension, make decisions, reach objectives, resolve problems in different ways, accordingly is an influential factor in learning, hence, this research that has a qualitative-quantitative, transversal, descriptive-correlational design approach, with a sample of 168 students, ages between 8 to 12 years of age. The main objective was to describe the influence of working memory on the academic performance of children from 8 to 12 years of age of the Unidad Educativa "San Francisco de Asis", to measure working memory, two subtests of WISC IV were applied: Retention of Digits and Succession of Numbers and Letters, to relate to the academic record. The results indicate the existence of a relation moderately significant between working memory and academic performance. Hence, in the present investigation it is concluded that the kids and girls with a good working memory development, they will have a better performance in the education field, however, it should be taken into account that the relationship found in this study is moderate, so it is suggested to take into account the presence of other factors involved in the student's academic performance.
Keywords: Executive Functions, WISC IV, learning, education.


Objective To investigate the effects of periodontitis and smoking by single factor and two-factor synergistic action on the peri-implant alveolar bone loss.Methods Four groups of posterior partially edentulous patiens were established:healthy control group;periodontitis group;smoking group;periodontitis combined with smoking group.ITI implants were embedding into the jaws of patiens in four groups seperately.X-ray examinations were made and implant marginal alveolar bone loss (MBL) were measured 12 months after loading with the SIDEXIS-XG software.Besides,12 months after loading,improved plaque index (mPLI),modified bleeding index (mSBI),probing depth (PD) were also recorded.SPSS 12.0 was applied to analyze the data.Results There were no significant difference between periodontitis group and healthy control group (P 0.05).Simultaneously,no significant difference between smoking group and healthy control group (P 0.05).There were,however,significant difference in the MBI and mSBI (P 0.05),no significant difference (P 0.05) in the mPLI and PD between smoking combined with periodontitis group and healthy control group.Conclusions Reliable effects can be achieved when ITI implant system is applied in periodontitis patiens with effective periodontal treatments and maintenances.However,it may appear obvious marginal bone resorption in periodontitis plus smoking group,which should be careful during cases choosing.


The recent dramatic fall in oil prices has led to extensive capital rationing in international oil companies, and subsequent fierce competition between resource extraction countries to attract scarce investment. This situation is not adequately addressed by the large literature on international taxation and multinational companies, since it fails to take account of capital rationing in its assumption that companies sanction all projects with a positive net present value. The paper examines the effect of tax design on international capital allocation when companies ration capital. We analyse capital allocation and government take for four equal oil projects in three different fiscal regimes: the US GoM, UK upstream and Norway offshore. Implications for optimal tax design are discussed.


Abstract A previous study (Godfrey, 1947) has indicated a relationship between egg shell color and hatchability. It was found that in certain brown egg laying breeds, the medium to dark brown shell colored eggs hatch better than do eggs with light brown shell color. The object of the present study was to determine whether or not dark brown shells were of better quality than light brown shells. In the first test of a possible association of egg shell color and shell quality, the specific gravity, egg shell color and breaking strength of 146 eggs from New Hampshire pullets (Ohio) were recorded the day after laying. Each egg was from a different hen so that the individual characteristics of several hens might not bias the sample. Specific gravity was determined according to Munro's (1940) method. Egg shell color was classified using the same color standards and the same color range as previously . . .


Objective To study the benefit effect of qi clearing heat and nourishing yin decoction on Th1 / Th2 related cytokine level in the mose model of lung cancer cachexia. Method The mice models of advanced lung cancer cachexia were established and randomized into four group:normal control group,model group,TCM group and MPA group. The levels of IL-2,IL-4 and IL-10 in spleen lymphocyte suspension were measured using enzyme linked immunosorbent assay(ELISA). Result The result of ELISA showed that IL-2 level in TCM group was higher than that in any other group,but IL-4 and IL-10 level were lower than those in other groups. Conclusion Qi clearing heat and nourishing yin decoction may weaken the immune disturbance of mouse model of lung cancer cachexia by adjusting the lvels of Th1 / Th2 related cytokines.


1. A method of performing hybrid automatic repeat request (H-ARQ), the method comprising the steps of: determining employed H-ARQ mode based on a coding type; transmitting to the receiving device a message indicating use H-ARQ mode; and transmit H-ARQ-packet using the H-ARQ.2 mode. A method according to claim 1, wherein the step of determining employed H-ARQ mode comprises determining employed H-ARQ modes based on the coding with a base or by combining tracked with increasing izbytochnostyu.3. A method according to claim 1, further comprising kotoryhopredelyayut type of DL-MAP, subtype DL-MAP, and the length of H-ARQ mode; and transmitting to the receiver a message containing the type of DL-MAP, subtype DL-MAP, and the length H-ARQ.4 mode. A method according to claim 1, further comprising kotoryhopredelyayut type of DL-MAP, subtype DL-MAP, and the length of H-ARQ mode; and transmitting to the receiver a message in form of an information element (IE) in accordance with standard 802.16, wherein the IE comprises a type of DL-MAP, subtype DL-MAP, and the length H-ARQ.5 mode. A method according to claim 1, wherein the message transmitting step comprises the step of transmitting the information element (IE) regime change in accordance with the IEEE 802.16 standard comprising H-ARQ.6 mode. Apparatus comprising an encoder for encoding data; logic for determining the type of H-ARQ based on the type of coding used by the encoder; and a transmitter for transmission by radio to the receiving device a message indicating the type of H-ARQ.7. The apparatus of claim 6, wherein the type of coding used comprises a base or combination of the monitored growing izbytochnost.8. The device according to claim 6, wherein the message sodas


This article is devoted to the analysis of antithesis as a stylistic device.Its functional possibilities in works of art by A. P. Chekhov written in 1890s are discussed.


Abstract : Composite oxide films on bare 2024-T3 aluminum were produced by surface chemical treatments followed by anodic oxidation in a barrier forming electrolyte. The chemical characteristics of the composite film are studied. This type of information can be important in determining the overall corrosion resistance and durability of adhesively bonded structures.


Greater amounts of oxalic acid and high shikimate dehydrogenase (SKDH) activity are associated with Helianthus annuus L. infected with Sclerotinia sclerotiorum (Lib.) de Bary, which causes Sclerotinia crown and stem rot. In order to evaluate the relationship between these two aspects of the infection process, we sampled seedlings of five sunflower genotypes, all inbred lines (HA 410, HA 411, HA 89, C, AC4122) which were subjected to artificial inoculation with the culture filtrate of Sclerotinia sclerotiorum. We also compared the effect of exogenous synthetic and endogenous production of oxalic acid in the samples. The reaction of the genotypes was measured as the reduction in many growth characters compared with the control. The measurements revealed more deleterious effects of exogenous oxalic acid than its endogenous addition, probably due to some unknown complex metabolism of this acid secreted by the pathogen. A positive correlation was found between the increase of oxalic acid and the increase of shikimate dehydrogenase activity in both treatments.


The major aim of this work is to uncover the accuracy of the Bitcoin price in any fiat/flat currency that can be predicted in advance. Bitcoin is a form of cryptocurrency and is now one of the most popular types of investments in the stock market. And bitcoin is the only form of cryptocurrency that has been on the rise in the last few years, and sometimes a sudden collapse without knowing the impact behind it in the stock market. To utilize the long short-term memory for predicting the bitcoin value in advance. Many researchers used RNN for this bitcoin prediction and observed that it lacks in consistency, to overcome this issue LSTM and ARIMA are used to ensure the accuracy and yields better prediction in terms of time series and proves that it is superior to existing state of art techniques.


Leucine (Leu) is the most potent branched‐chain amino acid that selectively enhances protein synthesis via intracellular signaling pathways. Since protein synthesis is an energy consuming process, we hypothesized that Leu may enhance mitochondrial biogenesis and functions. We determined the effect of Leu at mitochondrial mRNA levels, enzyme activities, and ATP production rate (MAPR) in cultured human liver cell line THLE‐3. Cells were pre‐incubated in a low‐Leu (0.1mM), serum‐free media for 24 hours and gene transcript profiles were measured using Affymetrix HG‐U133A GeneChips at 0, 30, 60, 120 and 480 minutes after increasing the Leu concentrations from to 2.0 mM. Thirty mitochondrial gene transcripts, both mitochondrial DNA and nuclear‐encoded, were significantly increased at various time points with treatment of higher concentrations of Leu. The mRNA levels of 6 mitochondrial genes including two ATP synthase, cytochrome P450, cytochrome C oxidase III, and NADH dehydrogenase 4 were confirmed by real‐time PCR measurements. Western blot analysis showed that 8 hours of high concentrations of Leu increased protein levels of key mitochondrial proteins, citrate synthase and cytochrome c oxidase I, by 42% and 20% respectively. In addition, the enzyme activity of citrate synthase was significantly increased by 25%, and MAPR by 30–40% using various substrates after 8 hours of high Leu. In conclusion, Leu stimulated mitochondrial biogenesis and oxidative phosphorylation in liver cells.


In this study, parents of pre-school children (0–6 years) answered an online questionnaire (444 girls, 447 boys). Children's bedtimes are earlier before weekdays and later before weekend days, and this difference becomes greater with age suggesting an increasing social jet lag at an early developmental stage. Half of the children have a sleep-onset latency of 15 min or shorter. When asked for children's optimal wake/bedtimes, parents would prefer later weekend rise times but earlier bedtimes both during the week and the weekend. Weekday rise times are determined by bedtimes during the week, awakening of children, parents' schedule and working hours per week. Bedtimes are determined by daytime napping, parental setting of bedtimes, and parental efforts for earlier bedtimes, parental efforts for regular bedtimes and by parental age. Chronotype changes and misalignment occurs at an early developmental stage, suggesting that parental influence exists and has an impact on the sleep–wake cycle (e.g. delaying of bedtimes at the weekend). We encourage parents to maintain a stable bedtime to avoid misalignment.


Cotton harvest can be increased by having real-time information on the state of cotton aphid populations. However, traditional cotton aphid monitoring relies on ground sample methods supported by models such as linear regression, resulting in low forecast accuracy. Therefore, this paper purposes to enhance the precision of the remote sensing prediction model by investigating the cotton aphid prediction model construction approach. We explored the effectiveness of the XGBoost algorithm combined with the GWO algorithm and SVR method for cotton aphid prediction relying on vegetation indices derived from UAV multispectral photography. Originally, 12 indices related to cotton aphids were calculated by UAV multispectral reflectance. Additionally, the optimal index combination for pest prediction was determined utilizing analysis of correction and two-way ANOVA, combined with the XGBoost algorithm. Furthermore, a pest prevalence prediction model for cotton aphids was constructed via the SVR methodology associated with the optimal catalog combination, and the model was optimized using the GWO algorithm. Compared with the seven algorithms, experimental results demonstrate that the MSE and MAE of the XGBoost-GWO-SVR model are reduced by 90.20% and 70.36% (SVR), 90.14% and 70.26% (XGBoost-SVR), 7.47% and 0.14% (XGBoost-GA-SVR), 5.80% and 0.11% (XGBoost-PSO-SVR), 12.06% and 58.95% (LR), and 84.77% and 89.22% (BPNN), whereas the <inline-formula> <tex-math notation="LaTeX">$R^{2}$ </tex-math></inline-formula> is increased by 22.5% (SVR and XGBoost-SVR), 0.3% (LR), and 12.51% (BPNN). The <inline-formula> <tex-math notation="LaTeX">$R^{2}$ </tex-math></inline-formula> of the prediction model of XGBoost-SVR combined with GWO, PSO, and GA is not significantly different. Among these models, the XGBoost-GWO-SVR obtained the highest <inline-formula> <tex-math notation="LaTeX">$R^{2}$ </tex-math></inline-formula> of 0.980 and the lowest MAE of 2.838.


This paper examines the relationship between political culture and information control. What does 'freedom of information' mean? Governmental institutions produce a diffused body of grey literature. Some parts of these vast grey information resources are accessible but a significant number are not for a number of reasons. On one hand the public in democratic societies has a right to know as formulated in freedom of information laws. On the other hand problems of national security do prevent and restrict access to grey resources. Secrecy has to be maintained because it concerns the quintessential function of the state. There is a public need to know if open government is the preferred political culture. But in an age with an ongoing war on terror, governments are understandingly less eager to stimulate an open society. Openness might harm the national security. This article evaluates (a) The historical background of government information resources in relation to freedom of information, (b) The working of the FOIA (Freedom of Information Act) in the United States and Europe in general and the public access to grey governmental resources, and (c) more specific the impact of the events of 9/11 and public access to grey government resources. Indicators show that government secrecy has continued to rise since September 11, 2001. However some progress has been made. In general the use of the different freedom of information laws in democratic countries to obtain information from the government continues to rise. Methodology and materials In this paper a case study is presented on the effects of 9/11 attacks and the availability of "sensitive" unclassified governmental information within the existing framework of national Freedom of Information Laws. The used methodology is a case study based on comparative research. Data for research was gathered and analyzed from reports and quantitative/qualitative data resources from different organizations: US government agencies i.e. the US General Accounting Office, European Union institutions and non-govermental organizations . In addition relevant international literature on the topic of Freedom of Information was researched.


Building on Polanyi's concept of the "double-movement" through which society defends itself against domination by the self-regulating market, this article sets out some key organizational and ideological hurdles that the contemporary "movement of movements" must surmount to challenge the hegemony of neo-liberal globalization. After outlining neo-liberalism's failures, it makes an argument for the possibility of "counter-hegemonic globalization," defined as a globally organized project of transformation aimed at replacing the dominant (hegemonic) global regime with one that maximizes democratic political control and makes the equitable development of human capabilities and environmental stewardship its priorities.


The temperature dependence of the dispersion relation of the transverse plasmon in a two-dimensional electron gas is calculated using the Sommerfeld expansion for the retarded current response function and the self-consistent linear response approximation for the electromagnetic field. The index of refraction and the penetration depth for the electromagnetic wave propagating in the two-dimensional electron gas are obtained.


Abstract 3134 Background: Concurrent t(14;18) and 8q24 translocations involving BCL2 and MYC in non-Hodgkin lymphomas (NHL) are rare, but are associated with a inferior overall survival (OS) regardless of the presenting or antecedent histological features (Johnson N, et al. Blood 2009). We sought to confirm these observations in an independent cohort of patients with NHL. Methods: Metaphase karyotypes and/or fluorescence in-situ hybridization (FISH) were used to identify cases of NHL with cytogenetic abnormalities involving 18q21 and 8q24 ( BCL2 and MYC ). Clinical and cytogenetic characteristics of these patients were assessed for correlations with pathological and clinical variables including outcome. Histological diagnoses were determined according to the 2008 World Health Organization Classification. Overall survival (OS) was calculated from the date a biopsy demonstrated an abnormality involving MYC to the last follow up date or death, as some cases acquired these lesions during their clonal evolution. Result: Among ∼1700 NHL patients diagnosed and/or treated at Stanford University Medical Center on whom cytogenetic studies were routinely performed, we identified 26 patients with evidence for concurrent cytogenetic abnormalities involving BCL2 and MYC . The histological diagnoses at the time of BCL2 and MYC rearrangements were available for 25 of the patients and included follicular lymphoma (FL1-2, n=3; FL3A, n=4), diffuse large B-cell lymphoma (DLBCL, n=2), and B cell lymphoma, unclassifiable, with features intermediate between Burkitt Lymphoma and DLBCL (BCLU, n=16). Cytogenetic analysis revealed that 13/26 cases with both BCL2 and MYC rearrangements had MYC translocations involving the immunoglobulin ( Ig) loci. However, in striking contrast to the MYC , without Ig- BCL2 rearrangements, 9 of these13 cases (69%) involved IgL t(8;22), and only 4 of these 13 cases (31%) involved IgH t(8;14). 9/26 MYC translocations involved various non- Ig loci (35%). One case (1/26) demonstrated amplification of ?both the BCL2 and the MYC loci by FISH, while one case showed trisomy 8 (1/26). Three cases had FISH analysis only, precluding assessment of the MYC rearrangement partner. No correlation between MYC partner and histology was observed, although this analysis was limited by small sample sizes. Non-FL histology correlated with significantly poorer than expected outcome, with a median OS of 4 months compared to 2 y for FL (p=0.003). Interestingly, we found cases with low-grade follicular lymphoma (FL1-2) histology which harbored both BCL2 and MYC rearrangements. To better define the frequency of 8q24 anomalies in an unselected cohort of follicular lymphoma cases, FISH for MYC and BCL2 rearrangements was performed on 192 independent low-grade follicular lymphoma (FL1-2) cases. While a subset of these cases (71) showed the expected frequency of BCL2 rearrangements (72%) by FISH, none showed concomitant 8q24 anomalies by FISH, suggesting that routine FISH analysis of low-grade follicular lymphoma for MYC rearrangements would have a low diagnostic yield. Conclusion: NHL with rearrangements of both BCL2 and MYC are under-recognized due to lack of routine karyotyping or FISH analysis. Comprehensive analysis of BCL2 and MYC status should be performed on all HGBCL in the new WHO (2008) classification, though the low frequency of these lesions among FL tumors precludes a similar conclusion for low grade NHL. Disclosures: No relevant conflicts of interest to declare.


—Open data initiatives have been gaining increasing momentum in recent times both with national government as well as regional governing bodies. Increasing number of governments are realising the need for the role of transparency in governance. In congruence to this, a number of governments have been working towards opening up government operational data to the public, however the data is extremely large, disparate and segmented, hence is hardly useable by general public as well as data consumers. A number of countries have worked on the open data initiatives and attempted to link the data using diverse frameworks and publishing tools. This paper presents an analysis of the works that have developed ontologies and frameworks to link the data released by governments as part of open data initiatives. It also provides a critical evaluation of the techniques used and suggestions of novel techniques that can be used to improve the frameworks and ontologies. We also present the results of a case study that used an ontology-based linking of data released by governments as part of the open data initiative. The results show that and an ontology mapping of such raw data drastically enhances the usability and the quality of the raw data.


1 The At-Risk Teenage Brain 2 Teaching the At-Risk Adolescent 3 Staying and Thriving in School 4 An Emotional Commotion 5 Emotions Gone Awry 6 The Social Life of Teens 7 Getting Physical 8 Meeting Special Challenges 9 Addiction: Alcohol, Drugs, and Smoking 10 One More Chance: Education in Juvenile Correctional Facilities


List of Contributors.Preface.Preface to the First Edition.Acknowledgements.I: Background to Medicines Research and Development.Pharmaceutical Medicine-A Specialist Discipline (F. Gabbay).The Contribution of Academic Clinical Pharmacology to Medicine Research (C. George).A Career in Drug Discovery (D. Ellis).II: Careers in Pre-Clinical and Clinical Research.A Career in Clinical Pharmacology (R. Yates).Career Opportunities for Physicians in the Pharmaceutical Industry (B. Spilker).The Clinical Research Associate (G. Hayes).Clinical Trial Administrator and Study Site Co-ordinator-Key Roles in Clinical Research (N. Murgatroyd, et al.).Statisticians in the Pharmaceutical Industry (C. Hilton and T. Lewis).Careers in Data Management (S. Varley).Working in a Contract Research Organisation (J. Barrett).III: Careers in Sales and Marketing.A Career in Product Management (R. Carlisle).A Career in Medical Sales and Medical Sales Management (R. Carlisle).IV: General Careers with the Pharmaceutical Industry.The Role of the Pharmacist in Healthcare (D. Jordan).Careers for Nurses with the Pharmaceutical Industry (J. Kenkre).The Toxicologist in Pharmaceutical Medicine (G. Diggle).A Career in Clinical Quality Assurance (R. Hattemer-Apostel).A Career in Product Registration and Regulatory Affairs (P. Turmer).Careers in Drug Safety and Pharmacovigilance (P. Barnes).Careers in Medical Information (J. Taylor).Medical Writing as a Career (B. Mullinger).Career Opportunities in Medicines Regulation-The Medical Assessor (N. Baber).Pharmaceutical Law - A Growing Legal Specialty (I. Dodds-Smith)Industry Careers for Pharmacoeconomists (N. Bosanquet).Consultant in Pharmaceutical Medicine (B. Gennery).V: Career Progression.Landing that Job-Recruitment, CVs and Interviews (S. Ransom).Career Development in Pharmaceuticals (R. Stephens).Opportunities for Education and Training in the Pharmaceutical Industry (P. Stonier and G. Hayes).Useful Information.Index.


【The purpose of the study is to analyze children's proportional reasoning and problem solving in proportional problems with/without iconic representations. Proportional problems include 3 tasks such as (a) without any picture, (b) with simple picture, and (c) with/without iconic representation. As a result, children didn't show any significant differences in two tasks such as (a) and (b). However, children showed better proportional reasoning with iconic representation. In addition, 'build-up expression' strategy was used mostly in solving problems and 'additive strategy' was shown as an error which students didn't make an appropriate proportional relation expression and they made a wrong additive strategy.】


Traditionally, security constrained economic dispatch is implemented by adding constraints to the plain economic dispatch-typically limits on line flows and nodal voltages for all credible post-disturbance configurations. However, advances in power electronics, and in particular the concept of FACTS are now challenging conventional approaches to system security operation, planning and overall economy of power systems. Based on FACTS devices, some part: of the security of the system can be achieved in post contingency mode, after an outage occurs. Such an economic dispatch, that incorporates the abilities of FACTS devices to assist in post-fault rearranging of transmission system power flows, allows the system to be operated with relaxed security most of the time. This results in reduction of the system operating costs without actually jeopardising the level of system security. In the context of the England and Wales electricity market, this paper demonstrates how FACTS devices can be used in uplift control. The paper proposes a method to the solution of the economic dispatch problem with an optimal balance between the level of security achieved in preventive and in corrective mode. The method is based on mathematical programming decomposition techniques that allow the iterative solution of a base-case economic dispatch for the intact system and separate contingency analysis with post-contingency corrective control by FACTS devices used to eliminate line/transformer overloads. A case study on a test system is presented and discussed.


An epidermoid cyst is a benign cyst of pilosebaceous origin. It is most commonly located on scalp, back and trunk1-3. Breast is a rare site for the occurence of this pathology. Very few cases have been reported in the literature 6,7. The mammographic and ultrasonographic pictures of this lesion can mimic carcinoma breast and thus identifying the lesion by fine needle aspiration cytology can help to reach the diagnosis with minimum effort and time.


In the era of miniaturization, micro energy storage devices become an essential part of the progress in many fields starting from simple sensors to medical devices. However upcoming developments in all these fields are restricted to finding safe, reliable and high-performance micro batteries with the shapes that is not limited only to rectangles, cylinders, and pouches. The research is confronted with challenges of fitting a battery into a microdevice. Lithium-ion batteries (LIBs), a mature energy storage technology, are a leading candidate for the development of micro batteries that can be easily integrated into microelectronic devices. However, despite significant achievements in the field of micro batteries, limitations in areal capacity and in power densities still motivate the search for alternative designs and novel concepts in the battery field. Insufficient areal energy density from planar micro batteries has inspired a search for three-dimensional micro batteries. The power output of a three-dimensional micro battery is expected to be higher than that of a two-dimensional battery of equal size, as a result of the higher ratio of electrode-surface-area to volume and lower Ohmic losses. Within a battery electrode, the 3D architecture provides large surface area, increasing power by reducing the diffusion path for Li ions. Additive manufacturing, also known as 3D printing, has appeared as a novel class of free form fabrication technologies that have a variety of possibilities for the rapid creation of complex architectures at lower cost than conventional methods. 3D printing enables the controlled creation of functional materials with three-dimensional architectures, representing a promising approach for the fabrication of next-generation electrochemical energy-storage devices and has many unique advantages over conventional manufacturing methods. In this work, printer is employed to print a 3D micro battery with MXene electrodes that can be printed easily and can be fitted into any small device.


Virtual laboratory is a computer application platform which use the application of virtual reality simulation technology. This paper discusses the application of virtual experiment in teaching professional practice of automation and indicates a typical open-ended virtual laboratory framework which is through a variety of simulation software and virtual instrument technology to achieve a combination of hardware. The paper also describes the teaching practice of professional design projects in a virtual laboratory platform through examples of ways. The operation of the laboratory reflects the higher engineering education in f a combination of the practice of teaching and the practical engineering design, at the same time the practice of students in the laboratory can stimulate students the awareness of independent study innovation.


Words are the basic material of langu age .It is very important for student s to grasp a certain amount of words.This paper d iscusses some methods that students should learn to grasp words:to combine words with its pron unciation and meaning;to associate as many words as pos-sible;to separate words according t o words formation,etc.Teachers should also encourage students to use words they have learned as ofte n as possible.


tal cancer incidental diagnosis or real association? Final answer. Journal of Clinical Gastroenterology, 50(S1), S39–S40. doi: 10.1097/ MCG.0000000000000643 . Shahedi, K., Fuller, G., Bolus, R., Cohen, E., Vu, M., Shah, R., . . . Spiegel, B. (2013). Long-term risk of acute diverticulitis among patients with incidental diverticulosis found during colonoscopy. Clinical Gastroenterology and Hepatology, 11(12), 1609–1613. doi: 10.1016/j.cgh.2013.06.020 . Slack, W. W. (1962). The anatomy, pathology, and some clinical features of diverticulitis of the colon. The British Journal of Surgery, 50(220), 185–190. doi: 10.1002/bjs.18005022012 . Spiller, R. C. (2015). Changing views on diverticular disease: Impact of waging, obesity, diet, and microbiota. Neurogastroenterology & Motility, 27(3), 305–312. doi: 10.1111/nmo.12526 . Sugihara, Y., Kudo, S., Miyachi, H., Misawa, M., Okoshi, S., Okada, H., & Yamamoto, K. (2016). Analysis of risk factors for colonic diverticular bleeding: A matched case-control study. Gut and Liver, 10(2), 244–249. doi: 10.5009/gnl14407 . Tursi, A. (2016). Diverticulosis today: Unfashionable and still under-researched. Therapeutic Advances in Gastroenterology, 9(2), 213–228. doi: 10.1177/1756283x15621228 . Ünlü, C., Daniels, L., Vrouenraets, B.C., & Boermeester, M. A. (2012). A systematic review of high-fibre dietary therapy in diverticular disease. Internationals Journal of Colorectal Disease, 27(4), 419–427. doi: 10.1007/s00384-011-1308-3 . Wensaas, K., & Hungin, A. P. (2016). Diverticular disease in the primary care setting. Journal of Clinical Gastroenterology, 50(1), s86–s88. doi: 10.1097/MCG.0000000000000596


Iridium trichloride reacts with PBut2Ph or PBut3(L) in propan-2-ol to give five-co-ordinate dihydrides [IrClH2L2]. The complex [IrClH2(PBut2Ph)2] reacts with sodium iodide to give [IrH2I(PBut2Ph)2] or with carbon monoxide to give [Ir(CO)ClH2(PBut2)Ph)2]. With dihydrogen and sodium propan-2-olate, [IrClH2L2] give the correspondlng pentahydrides [IrH5L2]. Hydrides of the type [IrCl3–xHx(PRBut2)2](a)x= 1, R = Me, or (b)x= 2, R = But react with sodium tetrahydroborate to give complexes [Ir(BH4)H2(PRBut2)2]. These are non-fluxionbl and have been characterized by 1H, 31P, and 11B n.m.r. spectroscopy. The complexes [Ir(BD4)H2(PBut3)2] and [Ir(BD4)DH(PMeBut2)2] have also been prepared by Li[BD4] reductions. The complex [Ir(BH4)H2(PMeBut2)2] decomposes slowly in deuteriotoluene to [IrH5(PMeBut2)2] but [Ir(BH4)H2(PButt3)2] seems to be indefinitely stable.


This work describes a new non-destructive method to determine the presence of anomalies such as Hardware Trojans in physical VLSI layer of FPGA, especially in configurable logic blocks and switch blocks. The detection that accounts for spatially correlated intra-die process variations can be achieved by isolating a suspected region where its device characteristic is inconsistent from ones in the physically nearest regions. This method does not require a golden chip to compare with a chip under test and can be performed without expensive testing equipment. In this paper, we present anomaly implementations and emulations as well as experimental results and analysis on anomaly detection from data obtained from Xili1nx Virtex-4, Virtex-5 and Virtex-6 FPGA devices.


Pneumatic muscle actuated translation modules represent an innovative solution for systems designed for wheelchairs endowed with robotic arms. Pneumatic muscle actuated robotic arms are intended to increase the degree of autonomy of persons with impairments of the lower and upper limbs. The paper presents in detail the construction of such a translation module, as well as its dynamic performance. Based on the obtained experimental results the dependencies of the stroke lengths achievable by means of pneumatic muscles on air feed pressure and load are highlighted. The developed empirical model gives a concrete and effective description facilitating the understanding of the mechanical behaviour of the pneumatic muscle, in view of optimal design and utilization.


Background: Acute kidney injury after pediatric cardiac surgery is a common complication with few established modifiable risk factors. We sought to characterize whether indexed oxygen delivery during cardiopulmonary bypass was associated with postoperative acute kidney injury in a large pediatric cohort. Methods: This was a retrospective analysis of patients under 1 year old undergoing cardiac surgery with cardiopulmonary bypass between January 1, 2013, and January 1, 2020. Receiver operating characteristic curves across values ranging from 260 to 400 mL/min/m2 were used to identify the indexed oxygen delivery most significantly associated with acute kidney injury risk. Results: We included 980 patients with acute kidney injury occurring in 212 (21.2%). After adjusting for covariates associated with acute kidney injury, an indexed oxygen delivery threshold of 340 mL/min/m2 predicted acute kidney injury in STAT 4 and 5 neonates (area under the curve = 0.66, 95% CI = 0.60 – 0.72, sensitivity = 56.1%, specificity = 69.4%). An indexed oxygen delivery threshold of 400 mL/min/m2 predicted acute kidney injury in STAT 1-3 infants (area under the curve = 0.65, 95% CI = 0.58 – 0.72, sensitivity = 52.6%, specificity = 74.6%). Conclusion: Indexed oxygen delivery during cardiopulmonary bypass is a modifiable variable independently associated with postoperative acute kidney injury in specific pediatric populations. Strategies aimed at maintaining oxygen delivery greater than 340 mL/min/m2 in complex neonates and greater than 400 mL/min/m2 in infants may reduce the occurrence of postoperative acute kidney injury in the pediatric population.


Abstract : This paper discusses the ability of regional powers, such as Iraq, to challenge the United States militarily within their specific region using Weapons of Mass Destruction (WMD). It looks at the U.S.'s readiness to counter proliferation of these weapons and our adversaries desire to have them to tip the balance of influence with the threat of use or actual use of WMD. This paper also looks at the reasons for the potential use by regional powers due to the erosion of traditional restraints in the international community.


Luo Rong-huan originated `Fanbian' strategy when leading the army and the people of Shandong province in fightings against the enemy's mopping-up and nibbling operations. `Fanbian' strategy means that, when the enemy attacked the base area, we would fight in the enemy-occupied area.This strategy is a kind of flexible practice of Mao Tse-tung's military thought on guerrilla warfare in the enemy-occupied area during the Anti-Japanese War. Its wide-spread practice, not only in Shandong province,but also nationwide,produces good results,which bears great significance.


The invention relates to an image identification technology-based license plate identification method. On the basis of vehicle partial feature information and background database information, a searching range of a license plate-covered vehicle is gradually reduced, thereby achieving an objective of assisted identification of a license plate-covered law-breaking vehicle. The provided identification method is characterized in that: an electronic eye, a local storage unit, a covering identification module, a data sending module, a background data receiving module, a background storage unit, a feature identification and extraction unit, a database processing unit, and a vehicle information database. According to the invention, real-time analyzing, identifying and sending are carried out on vehicle information shot by the electronic eye; after the background receives an image, the image is analyzed and queried; one piece of a group of vehicle information is returned; and a relevant comparison operator only needs to carry out comparison on the one piece of the group of vehicle information. Therefore, the work load of the relevant comparison operator is substantially reduced; and the efficiency for illegal behavior identification of license plate covering can be substantially improved.


Summary

Capillary supply in the gluteus medius of red cell hypervolaemic and normovolaemic horses was investigated. Muscle biopsies were taken from 2 groups of 4–9-year-old stallions: 10 normovolaemic (NV, CV/bwt=78.1 ml/kg) and 10 hypervolaemic (HV, CV/bwt=112.6 ml/kg). The muscle biopsies were analysed for fibre type composition, fibre areas, capillary supply and enzyme activities. There were no differences between groups for fibre type composition, fibre areas or enzyme activities. Hypervolaemic horses were found to have a significantly lower capillary density (HV: 587 ± 62; NV: 661 ± 57 cap mm−2), capillarisation in relation to mean fibre area (HV: 1.59 ± 0.19, NV: 1.77 ± 0.16 μnr2 10−3) and especially capillarisation of type I fibres (HV: 1.87 ± 0.24; NV: 2.15 ± 0.26 μm−2 10−3). The lower capillarisation of hypervolaemic horses could be one factor affecting their racing performance.


During the time of the war of resistance againse Japan economey of Shan-Can-Ning Borders was very adverse and impecunious. The borders' people civil and militant have to shoulder upon the tasks to claim land, plant cotton to break the enemy's blockade and fulfil self-supporting production. All these measures had virtually relieved the pressures and also set a good example for the late explorers of the north-west resources.


To elucidate the ancestry of the allopolyploids E. stevenii and E. boöphthona, I examined eleven isozyme loci and 24 morphological characters from 28 populations representing five related Euphorbia species from Australia. According to an analysis of genetic and morphological data, three diploid species differentiated recently, but two independent polyploid species are estimated to have differentiated a relatively long time ago. Fixed heterozygosity for most isozymes in E. stevenii and E. boöphthona strongly suggests that these two species are allopolyploids rather than autopolyploids. The isozyme profiles of E. stevenii indicate that it is an allopolyploid that evolved from interspecific hybridization between the diploid E. tannensis and unidentified or extinct tetraploid species. In addition, isozyme patterns strongly suggest that E. stevenii was one of the ancestors of E. boöphthona. However, E. boöphthona showed a large number of fixed alleles that were not detected in any other Australian Eremophyton species. The most likely hypothesis for the origin of E. boöphthona is that it was formed by hybridization and chromosomal doubling between an extinct diploid species and the hexaploid E. stevenii.


In mobile speech communication, adverse conditions, such as noisy acoustic environments and unreliable network connections, may severely degrade the intelligibility and natural- ness of the receive ...