Background and Purpose: Problems of the occupational health management are posing serious challenges before the mankind globally. Occupational disease if unaddressed leads to deviation from health. The aim of the study is to study the prevalence of respiratory symptoms and lung function abnormalities and to find out the usefulness of protective mask in reducing respiratory symptoms in tobacco workers. Materials and Methods: Quasi experimental study includes those workers exposed to tobacco dust in beedi industry recruited with minimum of three years of experience and age group of 20 to 40 years. Control group includes age and sex matched subjects who are not exposed to tobacco dust. Results: There were significant difference exist between experimental and control group in the prevalence of respiratory symptoms. How ever there was no significant difference between FEV1 and FEF (25-75) between two


By use of the Arrhenius theory based concrete adiabatic temperature rise and creep models, and in consideration of the influences of temperature on hydration heat chemical reaction rate and creep property of concrete in the early age, an analysis is performed of the temperature induced stresses and cracks in massive concrete walls. In the analysis, a semi analytical method is proposed to solve nonlinear differential equations, and Bazant's crack band model is used to calculate the temperature induced cracks. The cracks are divided into equal strips, and the semi analytical iteration method with stepwise loading is developed to calculate the relationships between temperature, stresses, and propagation of cracks. The results show that the cast temperature of concrete is of great effects on the thermodynamic property of materials and on temperature rise and temperature induced stresses and cracking of concrete structures. Besides, the influences of different curing conditions on temperature, stresses, and cracking of concrete are also revealed.


A novel severe plastic deformation technique entitled rubber pad tube straining is proposed suitable for manufacturing of high-strength ultrafine-grained and nanostructured thin-walled cylindrical tubes. A punch with a convex portion in the middle is pressed down into a tube constrained with a hollow cylindrical rubber supported by a rigid cylinder. Tube diameter increases and decreases incrementally when the punch is pressed down, and the rubber pressure pressed back the tube diameter to its initial size. This process was performed on a commercially pure aluminum tube. Finite element results revealed that the equivalent plastic strain of about 1 could be reached at the end of the first cycle of rubber pad tube straining while having a good strain homogeneity along the thickness and length. Experimental results showed that the yield and ultimate strengths were increased to about 172 and 182 MPa from the initial values of about 80 and 128 MPa, respectively. Also, the hardness was increased to ∼55 HV from ∼44 HV.


I n this paper we establish some sufficient conditions for the oscillations of all solutions of the second order nonlinear neutral advanced functional difference Equation


The solution of the problem of the civilizational development of mankind is unthinkable without referring to the provisions of the founders of the theory of civilization. In a comparative analysis of the theories of L. G. Morgan and F. It was revealed by Engels that the main engine of the progressive movement in the fi rst case is the production of means of subsistence, in the second — the production of means of production. The universality of the theory of civilization F. It is impossible to imagine Engels without the reasoned, historically reliable theory of L. G. Morgan. This is only the fi rst approximation to reading and understanding the work of F. Engels' "The Origin of the family, Private property and the state". In the future, it is necessary to consider in more detail the role of the family and private property in the process of civilization formation. This article can be used in the course of studying the new discipline "Fundamentals of Russian statehood" introduced into the higher education system.


the standardised tests applied showed no significant difference to the gen eral public. Nonetheless some families could be identified as having severe coping difficulties with 2 to 4 members displaying psychosocial problems of a very high degree. Both groups of families profited in the same degree from the rehabilitation; this effect shows great stability for the families coping good, whereas those with coping difficul ties worsen considerably, almost always beyond the de gree displayed before the rehabilitation. To identify these families quickly and offer them support it seems necessary to establish an out-patient psychosocial follow-up.


The RICOVER60 trial has shown that 6 cycles of CHOP-14 with 8 applications of rituximab (6xR-CHOP-14) was superior to 8xR-CHOP-14, 6xCHOP-14 and 8xCHOP-14 in elderly patients with CD20-positive aggressive lymphoma. In that trial 117/306 (36%) of the patients in the 6xRCHOP- 14 arm were assigned to receive additional radiotherapy (Rx) to bulky disease (Pfreundschuh et al., Lancet Oncol 2008). To study the relevance of additional Rx to bulky disease we subsequently initiated a prospective study in which no Rx was planned after 6 x R-CHOP-14.


We propose real-time vibration displacement measurement system using probe light modulated by phase-modulated RF signal. The reflected probe light is processed by a signal detection unit composed of an optical intensity modulator and lock-in amplifier. Proof-of-concept experiment demonstrates real-time measurement of 50-Hz vibration displacement with an amplitude of 21 mm.


western Medical School has appointed Alfred Gilman, MD, PhD, to the position of dean. Gilman has served as interim dean since the May 2004 departure of Dr. Robert Alpern and will continue his oversight of the faculty, medical students, and clinical residents. Gilman was recruited to UT Southwestern in 1981 to chair the Department of Pharmacology. Thirteen years later, his discovery of G proteins and their role in cellular communication earned him the 1994 Nobel Prize in Physiology or Medicine. In 2000, he established the Alliance for Cellular Signaling, an interdisciplinary effort to advance the understanding of cell communication. Although Gilman will relinquish his chair, he will continue his leadership of the Alliance, as well as of the Cecil H. and Ida Green Comprehensive Center for Molecular, Computational, and Systems Biology. Gilman earned his bachelor's degree in biochemistry from Yale University and his MD and PhD in pharmacology from Case Western Reserve University. After his postdoctoral research in the Laboratory of Biochemical Genetics at the National Institutes of Health, Gilman joined the University of Virginia School of Medicine, where he served in the Department of Pharmacology for 10 years. Gilman holds the Raymond Willie and Ellen Willie Distinguished Chair in Molecular Neuropharmacology, in Honor of Harold B. Crasilneck, PhD, the Nadine and Tom Craddick Distinguished Chair in Medical Science, and the Atticus James Gill, MD, Chair in Medical Science.


7373 Background: Local suppression of immunity is a potential mechanism for tumor escape from immune surveillance, and may represent an obstacle to immunotherapy. We previously reported high apoptosis of lung resident T cells in NSCLC, and the presence of regulatory/suppressor CD4 T cells.

METHODS
We used multi-parameter functional flow cytometry to measure the differentiation state, activation, and apoptosis of lung resident CD4 and CD8 T cells in matched broncho-alveolar lavage (BAL) samples from 5 healthy volunteers and 66 patients with unilateral resectable lung tumors with paired BAL ipsilateral and contralateral to the tumor.

RESULTS
In healthy subjects, BAL T cells were predominantly CD4+ (mean +/- SEM: 68 +/- 3%) and expressed a phenotype consistent with mucosal memory-effector T cells (CD45RO+, CD45RA-, CD103+, CD27-) (77 +/- 6% and 73 +/- 10%, for CD4+ and CD8+, respectively). 18+/-3% of normal lung resident memory T cells bound Annexin V, an early marker of apoptosis. Effector-memory cells also comprised the majority of CD4 and CD8 lung T-cells in NSCLC BAL (67 +/- 5 and 87 +/- 2%), but CD8 predominated (54 +/- 4%). The great majority of CD4 and CD8 effector-memory cells bound Annexin V (81 +/-3 and 80 +/- 14%), and were CD28- (42 +/- 4 and 77 +/- 3%). These cells also bore the late activation marker HLA-DR (65 +/- 4 and 33 +/- 6%), but were not in cycle as indicated by transferrin (CD71) expression. BALs obtained ipsilateral and contralateral to the tumor were indistinguishable by all comparisons.

CONCLUSIONS
The data indicate that lung T cells respond as a physiological unit. This may result from a common inflammatory stimulus affecting both lungs, or alternatively may represent sympathetic inflammation as has been observed following eye trauma. In either case, the preponderance of apoptotic memory-effector cells expressing late activation markers without evidence of proliferation suggests the chronic influx and activation of memory cells, followed by their rapid death and clearance. No significant financial relationships to disclose.


In order to estimate the visibility of temporal light modulation (TLM), also known as "flicker", various metrics are employed in research and commerce. The metrics, however, are not easily calculated, and occasionally the values change depending on sampling rates. This study investigates the complexities involved in processing data from TLM waveform metrics and then calculating metrics. It explores the sensitivity of each metric to sampling rate, and recommendations are then provided for how to increase the accuracy and consistency of the metrics by using appropriate sampling rates. The analyses in this study are based on noise-free and stable ideal waveforms; however, sampling rate effects also exist for real-world waveforms.


Many of the patients with Minamata disease, caused by methylmercury have developed hypertension. In experimental methylmercury poisoning, the level of mercury and the mortality are higher in spontaneously hypertensive rats (SHR) than in Wistar-Kyoto rats (WKY). Thiophene induces cerebellar degeneration, which is also found in rats with methylmercury poisoning and hepatic necrosis. To clarify the pathophysiology of the thiophene-induced lesions female SHR and WKY aged 150 days were studied and a comparison was made between the two strains. Up to an age of 150 days, the body weight of SHR was less than that of WKY, but food consumption by SHR was higher than that of WKY. SHR were more susceptible to thiophene poisoning than WKY in terms of symptoms, changes in auditory brainstem response (ABR), and histopathological findings. Administration of pentobarbital was more effective in producing hepatic lesions in SHR than in WKY. Ultrastructurally, nuclear chromatin segregation and irregular distribution of rough endoplasmic reticulum (rER) were prominent in the hepatic cells of non-treated SHR. An osmiophilic homogeneous substance appeared to play an important role in the formation of cerebellar lesions in both SHR and WKY. The hepatic injury and disturbance of cerebellar blood vessels seem to cause the cerebellar lesions. It is suggested that a reduced ability for drug metabolism in SHR, which might be inherited or acquired, is one of the causes of the higher susceptibility of this strain to thiphene poisoning, compared with WKY.


Aiming at the problems of how the national enterprise effectively dispose the subsidiary company and reasonable adjust the labor of each subsidiary company,it represents the conception,constitution of the distributed design management of Fulu and the merits of it,discusses the methods and process of distributed design management of national project enterprise,and introduces the managing tool of distributed design management in the end,to supply reference.


OBJECTIVE
To analyse the pharmacological profile and the anatomical localization of the dopamine D1 and D2 receptors in sections of the pelvic part of the ureter and of the fundus of the urinary bladder.

PATIENTS, MATERIALS AND METHODS
Samples of the pelvic part of the ureter and of the fundus of the urinary bladder were taken in men (age range 61 +/- 4 years) who were undergoing lower urinary tract surgery. Biochemical characterization and autoradiographical techniques were used on frozen sections of the ureter or the urinary bladder. [3H]-SCH 23390 was used as a ligand of dopamine D1 receptors and [3H]-spiroperidol as a ligand of dopamine D2 receptors.

RESULTS
[3H]-SCH 23390 and [3H]-spiroperidol were bound by specific sections of the ureter and of the urinary bladder. The pharmacological profile of the binding was consistent with the labelling of D1 and D2 receptors respectively. Light microscope analysis of the localization of D1 and D2 receptors revealed the accumulation of the two radioligands in the tunica muscularis of the ureter or of the urinary bladder.

CONCLUSION
A possible role of the dopaminergic system in the control of urine flow and of some dysfunctions of the lower urinary tract is suggested.


ABSTRACT A range of commercial chitosans were sourced and their molecular size profiles and degrees of acetylation (DA) were determined by HPSEC and 1 H-NMR spectroscopy, respectively. Chitosans were subsequently utilised for modification of alginate fibres, and levels of chitosan incorporated into base fibres were estimated by elemental analysis. Elongation (%) and tenacity of resultant chitosan/alginate fibres were determined in order to assess their potential application in wound dressings. A range of chitosan contents (˜ 0-6 % w/w) resulted from a variety of alginate and chitosan starting materials. Fibres produced from sodium alginate (A1, 6%) using hydrochloric acid (0.2M) at a draw ratio of 1.18, and treated with chitosan (C1, 3.2%) were deemed to have the best properties. In general, use of a water washing stage resulted in the production of better chitosan/alginate fibres. Treatment with chitosans generally resulted in a reduction in tenacity (and a reduction in % elongation if a water washing stage was not used), i.e. no increase in fibre strength was observed, implying that the chitosan is more like a coating rather than penetrating/reinforcing the alginate fibre.


Aim To study the therapeutic effect of hesperidin (HDN) on adjuvant arthritis (AA) in rats and its mechanisms.Methods Freund's complete adjuvant (FCA) was used to induce AA in rats. Secondary paw swelling of AA rats was measured with volume meter. Splenic lymphocyte proliferation response induced by concanavalin A (ConA) or lipopolysaccharide (LPS) was examined with MTT assay. IL-2 production of splenic lymphocytes and IL-1, IL-6,TNF-α productions of peritoneal macrophage (PMΦ) were determined by radio-immunity assay.IL-10 production of PMΦ was estimated by enzyme linked immunosorbent assay (ELISA).Results The secondary inflammation of AA rats appeared on the 12th day after injection of FCA. At the same time (d 12), HDN (40,80,160 mg·kg-1,×12 d) were given to AA rats by intragastric administration. It was found that HDN(80, 160 mg·kg-1) could significantly inhibit the secondary paw swelling of AA rats from the 20 th day.The suppressed lymphocyte proliferation and IL-2 production of splenic lymphocytes in AA rats were reversed by treatment with HDN. Meanwhile,HDN could remarkably down-regulate IL-1,IL-6,TNF-α productions of PMΦ and up-regulate IL-10 production of PMΦ.Conclusions The results suggested that HDN had therapeutical effect on AA rats. Its mechanisms may be related to adjusting abnormal immune function in AA rats and keeping the balance of cytokine network.


High-rise green buildings are gaining interest worldwide as a response to global climate changes. This irreversible trend will undoubtedly create modifications in the response of buildings against fire occurrence, growth and spread and the recent dramatic fire event at the Grenfell Tower in London provides daily proof that we need to improve our fire safety strategies regarding the increasing amount of combustible materials present in our buildings and possibly used in façades. The fire safety of façades in high-rise wood building is therefore a challenge that we are going to face. This paper presents the knowledge acquired in France through an extensive national research project still on-going during which intermediate and large-scale fire tests of wooden façades with different cladding materials, surface treatments, cavity barriers, insulating materials and structures were performed. The paper focuses on cladding systems with different reaction to fire classes put on timber structures with an air gaps behind the outer claddings. Finally, this paper describes the guidelines which have been recently endorsed by the French public authorities in February 2017, and provides perspectives towards the development of numerical models able to capture the fire spread behaviour on a combustible façade.


The article is devoted to the study of the poetics of F. M. Dostoevsky's novel "The Brothers Karamazov". This problematic area, despite active research attention, still contains a huge potential for further discoveries. The author focuses attention on the actual problem of subject-material representation of artistic space. This work aims is to study book topics, to identify a system of relationships between stable images and motives, which are represented in the text as the lexeme "book" and its derivatives. Based on predecessors' studies (A. P. Vlaskin, G. Ya. Galagan, L. V. Karasev, N. A. Makaricheva), the author puts forward and defines the idea of the functioning of the "ontological scheme" of the plot, which is formed by the subject-symbol "book". Despite the relative paucity of plot situations with the point of presence of the book, a wide branching of the scheme is revealed, because of the principle of duality inherent in Dostoevsky's poetics as well. In conclusion, the author argues about the significance of this "ontological scheme" for understanding the idea of the novel in connection with the breadth of the semantics contained in it: knowledge, memory, enlightenment, change, "second birth". The article consists of four parts, which examine in detail the functioning of the book topic in different plot fragments: in the preface "From the Author", in the narrator's reports about the biography of Smerdyakov and Krasotkin, in the third meeting of Ivan Karamazov with Smerdyakov. The author uses the structural-semiotic method of studying the text with elements of mythopoetic and ontological approaches.


In this paper we analyze the convergence behavior of convolution-type system representations for the Paley-Wiener space PWπ1. We completely characterize all stable linear time-invariant (LTI) systems for which we have convergence in the distributional sense by giving a necessary and sufficient condition for convergence. Furthermore, we prove that there are stable LTI systems and signals in PWπ1 for which the convolution integral and the convolution sum diverge even in a distributional sense. In signal processing, distributions are often used to show convergence. Surprisingly, here we are in a situation where distributions cannot be used to justify convergence.


ABSTRACT Alarmism has enabled the extension and reconfiguration of sovereign power at thresholds of human mobility in ways that exemplify the shifting and polymorphic nature of borders. Extending critical geopolitical scholarship on alarmism and the geographies of bordering, this paper examines how alarmism is used to exert control over legal-discursive thresholds that people must cross to gain political asylum in the US. By analysing the most ambiguous area of asylum protection: proving that persecution is motivated by one's "membership in a particular social group", I demonstrate how refugee definitions are often contested and changed in response to "floodgate fears", a type of alarmist legal argumentation. Rather than addressing the merits of an individual asylum case, the floodgate argument invites speculation about the effects a particular juridical decision will have on future cases, and therein translates wider racist, nationalist fears of being overwhelmed by alien "others" into otherwise banal legal codes. In precedent-setting asylum law, these fear-laden speculations can shape legal-discursive thresholds for years to come, enacting targeted exclusion and widening the pool of "legitimate" targets of evolving border enforcement tactics. This analysis of legal alarmism and the formation of asylum case law focuses on the unique relationship between the particular social group threshold and the history and contemporary struggles of Central American asylum seekers.


)This article explores how state legislators use statehouse reporters in Indiana for information and publicity purposes. Different characteristics of lawmakers associated with particular motivations for using reporters are identified. Legislator characteristics also are related to how these reporters are perceived to influence the policymaking process. Mass media facilitate the exchange of information between policy-making bodies and the public. Legislators are heavy consumers of information supplied by mass media and other sources such as interest groups, constituents, technical experts and colleagues, Lawmakers also are important sources of information and opinion that the mass media transmit to society. Reporters are gatekeepers to media access for public officials who wish to reach broad audiences. Reporters also may be


The philosophy of practice does not aim at the peaceful resolution of existing contradictions in history and society but is rather the very theory of these contradictions.


While the benefits of the interdisciplinary unit are well documented, it presents a complex challenge to teachers in the natural and social sciences, mathematics, and humanities. Teachers must become active curriculum designers who shape and edit the curriculum according to students' needs. This paper describes knowledge for teachers as curriculum designers and a framework for interdisciplinary unit development. The framework addresses a metacurricular process (problem solving) that will be the unit centerpiece, the development of this central process related to the learner, and the tasks that teach explicit learning and thinking skills attached to the central process. An example of the framework in action is also described. As the faculty and curriculum coordinators for an innovative summer academy for minority students in northern Arizona have used this framework, they have evolved from a group that created a good idea to interest students with parallel subject development in separate classrooms to humanities/mathematics/science teams united in one team/classroom, in which content is integrated through the actions of the problem solving process.


A three-dimensional (3D) hybrid nanostructure of Fe3O4 nanoparticles uniformly anchored on vertically-aligned carbon nanotubes (VACNTs) was fabricated by a facile two-step method. Assisted by supercritical carbon dioxide (SCCO2), the Fe precursor was firstly absorbed on CNT surface and then transformed into Fe3O4 nanoparticles by vacuum thermal annealing. Owing to the synergetic effects of well-distributed Fe3O4 nanoparticles (~7 nm) and highly conductive VACNTs, the hybrid electrode exhibits a high specific capacitance of 364.2 F g−1 at 0.5 A g−1 within the potential range from −0.9 to +0.1 V in Na2SO3 electrolyte and an excellent cycling stability of 84.8% capacitance retention after 2000 cycles at a current density of 4 A/g. This 3D hybrid architecture consisting of aligned CNTs and pseudocapacitive metal oxide may be a promising electrode for high-performance supercapacitors.


Abstract : The report describes a series of apparent-weight measurements of (a) two static thrust cell-test bay assemblies, located at the Allegany Ballistics Laboratory (ABL), (b) the ABL X-248 motor installed in the static firing stand, and (c) several 'representative' rocket payloads. The procedure used in obtaining these measurements is described in some detail. Since this information was desired to ensure greater confidence in the quantitative levels of motor-induced oscillatory forces (600 cps) observed during earlier firings, the behavior at this frequency was studied most closely. However, the results also show how these several structures may be modeled, mathematically, for analysis pruposes. The studies illustrate the usefulness of these mechanical-impedance type measurements when dynamic loads are of importance. (Author)


The notion of proxy information seekers or lay mediaries has risen to the forefront of recent information behavior research. Defined broadly as people who seek information on behalf of others without necessarily being asked to do so or engaging in follow-up with the recipient(s), lay mediaries are becoming more prevalent and thus identifiable due to expanding information and communication technologies such as forwarding and other Web-based alerting services. The bi-fold purpose of our poster is to review past research on lay mediaries and related notions, and to propose a conceptual model that can be used to base future empirical and theoretical work.


fDDQ production testing technologies have been developed for 0.8 pm CMOS Sea-of-gate IC's (SOG). Over 400 samples were measured, and the results of conventional testing and IDDQ testing were compared. IDDQ tcsting proved to have high fault coverage and very effective for testing CMOS VLSIs such as SOG.


A new induction melting furnace with a cold-copper crucible has been designed and constructed using ultra-high vacuum technology. The main chamber can be evacuated to 6.7 × 10—8 Pa as the base pressure. The furnace can melt high-purity iron of 10 kg, at most, within 300 s. The total pressure becomes less than 4 × 10—6 Pa during melting of iron under the best condition. As starting materials for melting, high-purity electrolytic iron containing impurities of 25.2 massppm which is determined after the analysis of 18 elements was prepared. The content of gaseous impurities such as carbon, nitrogen, oxygen, sulfur and hydrogen is 19.6 massppm in total. It is concluded that ultra-high vacuum melting of iron is quite useful to increase the purity of iron. The total content of impurities in iron is reduced from 25.2 to 12.6 massppm by melting under the atmosphere of 7.5 × 10—6 Pa. The amount of gaseous impurities can be reduced from 19.6 to 10.1 massppm in total. Especially, the amount of oxygen is reduced from 14.1 to 7.5 massppm. These amounts of gaseous impurities are almost the limit of detection by conventional methods of analysis.


Modern power system becomes more prone to cyber attacks due to the high integration of information technology and communication network. In this paper, we investigate the impact of multiple solutions to the security constrained economic dispatch, a tool used by power system operators to ensure the economics and security of the system operation, on the line attacking strategy, and model the line cyber-attack problem as a trilevel mixed integer linear programming problem. We convert the middle and lower levels into a single-level optimization problem using a weighting factor without introducing any additional variables and constraints. The simulation results on the modified IEEE 14-bus system verify the correctness of the proposed model.


Pneumoperitoneum as a complication of barotrauma is a rare condition due to mechanical ventilation. The diagnostic dilemma often leads to perform an exploratory laparotomy, with the suspect of perforation of a hollow viscus, that makes worse the prognosis of these patients. We describe three patients who developed pneumoperitoneum, secondary to barotrauma. In the last one the use of laparoscopy allowed us to avoid an useless laparotomy.


Objective To study DNA polymeraseβ(polβ) gene mutation in human nasopharyngeal cancer. Methods Twenty-six cases of nasopharyngeal carcinoma tissues and control epithelial tissues were collected to study DNA polβgene mutation with PT-PCR, PCR-SSCP and DNA sequence analyzing technique. Results polβ gene mutation was identified by SSCP in 8 of 26 nasopharyngeal cancer tissues (with mutation rate 30.8%) and there was no mutation in juxtacancerous tissues. Many kinds of mutation were found by DNA sequencing. Conclusion The study proves polβ alternation in human nasopharyngeal carcinoma, this results in sequence alternation in amino acid and spatial structure changing. These mutations may play an important role in carcinogenesis of nasopharygeal cancer.


Radiofrequency Maze Procedure and Atrial Size. Introduction: Previous studies showed that the surgical maze procedure can restore sinus rhythm and atrial transport function in patients with chronic atrial fibrillation (AF). However, no previous studies discussed the association of atrial size reduction and the success of sinus conversion by the radiofrequency (RF) maze procedure for chronic AF.


The oxidizing behavior of titanium alloy in isothermal forging was analyzed. The oxidative cleavage model was established, the influence factor of high temperature oxidization for titanium alloy was discussed. Thus the efficient measure of preventing from oxidization was introduced to improve the superplastic deformation and quality of isothermal forging for titanium alloy.


2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 Faster and Worst-Case Optimal E-matching via Reduction to ConjunctiveQueries Yihong Zhang∗ firstname.lastname@example.com University of Washington Seattle, WA, USA 1 PROBLEM AND MOTIVATION An e-graph is a data structure that efficiently represents sets of congruent terms [6]. It has a long history of applications in automated theorem proving [2, 4, 6, 8, 11] and is re-purposed in the last decade for program optimization, known as equality saturation [5, 9, 10, 12–14]. A fundamental query operation on e-graph is e-matching [2, 4], which finds the set of terms in the e-graph matching a given pattern. E-matching is the bottleneck of many equality saturation–based program optimizers [9, 13, 14] and is a central procedure in state-of-the-art SMT solvers, including Z3 [3] and CVC4 [1]. Therefore, the performance of e-matching is critical. Several optimizations are proposed for e-matching [2, 4]. However, to our knowledge, existing e-matching algorithms are based on naïve backtracking, which is suboptimal in many cases. For example, they do not exploit the equality constraints implied by multi-occurrences of a variable, which is nonetheless common in practice. To tackle this inefficiency, we propose to take a relational view of e-graphs. Under this view, e-matching corresponds naturally to a restricted class of relational queries, known as conjunctive query (CQ). By treating e-matching as an instance of CQ, we benefit from decades of research from the database community. In particular, by using the recently discovered generic join algorithm [7], our ematching algorithm guarantees worst-case optimality and achieves more than 400× speed-up in our preliminary experiments.


A Ti:sapphire based laser system provided 30-fs pulses centered at 800 nm with up to 3 mJ energy was used in the experiment. The input beam was focused by a concave mirror with radius of 3 m into a 1.5 m long glass cell. No iris-diaphragm or other beam reshaping tools were used for filament adjustment. The gas cell was filled with SF6 or for comparison with Ar at variable pressure of 0.1–0.7 bar. After the filament start point the laser radiation was spatially confined and propagated through the entire gas cell. Diameter of central, bright part of the beam was in a range of 2 mm directly after the output window. The output spectra recorded directly after the cell filled gases are shown in Fig. 1. The filament in SF6 demonstrate qualitatively different spectral shape, as compared to Ar, with dramatic enhancement in frequency conversion out of fundamental spectral range especially towards the higher-frequency domain. FWHM of the detected spectrum reached almost octave bandwidth of 440–875 nm.


This paper describes our study on identifying semantic relations that exist between diseases and treatments in biomedical sentences. We focus on three semantic relations: Cure, Prevent, and Side Effect. The contributions of this paper consists in the fact that better results are obtained compared to previous studies and the fact that our research settings allow the integration of biomedical and medical knowledge. We obtain 98.55% F-measure for the Cure relation, 100% F-measure for the Prevent relation, and 88.89% F-measure for the Side Effect relation.


A patient with a normally functioning kidney transplant, received from an ABO and HL-A-identical sibling donor, experienced sudden and irreversible cessation of renal function 22 days after transplantation. Histological examination of the kidneys revealed diffuse intravascular coagulation, but circulating antibodies could not, be detected before or after the transplant was removed, nor could they be eluted from the kidney itself. Skin transplantation from the same donor later confirmed that there had been no major tissue antigen mismatch and revealed no evidence of sensitization from the previos-kidney transplant. The findings are strongly suggestive of a localized Shwartzman reaction precipitated by the presence of gram-negative bacteremia in a patient with an allograft who received steroids.


Introduction It has been proposed that oxygen functional groups (i.e., carboxylic acids and their salts, phenols, and ethers), prevalent in low rank coals, are responsible for cross-linking reactions that inhibit the efficient conversion of low-rank coals to liquid fuels and chemicals. In the pyrolysis and liquefaction of low-rank coals, cross-linking has been correlated with evolution of CO2 and H2O. To determine if decarboxylation leads to cross-linking, the thermal decomposition of aromatic carboxylic acids was investigated. It was determined that carboxylic acids predominately undergo decarboxylation by an acid promoted ionic pathway at 400 °C, but depending on the reaction conditions, small amounts (<5 mol%) of cross-linked products (i.e., arylated products) could be formed by formation and radical induced decomposition of anhydrides. Anhydride formation and cross-linking reactions were enhanced by incorporating the aromatic carboxylic acids in a polymer (poly(mxylylene)-co-(5-carboxy-m-xylylene) at concentrations similar to those found in low rank coal (ca. 2.4 carboxyls per 100 carbons). Since these condensation reactions readily occur at temperatures found in the thermal processing of coal (350-425 °C), additional types of cross-linking reactions, such as the condensation of carboxylic acids and phenols to make aryl esters, might be possible. Since phenols are 2-5 times more concentrated than carboxylic acids in low rank coal, aryl esters could form from condensation reactions. Aryl esters are predicted to be thermally stable up to temperatures of 650 °C based on the Arrhenius parameters reported for the C-O homolysis of phenyl acetate (log k (s) = 15.3 – 72.3 kcal mol / 2.303RT). Pyrolysis of phenyl benzoate at 700 °C produced 90% conversion, and produced phenol, biphenyl, benzene, and dibenzofuran as the major products, but the mass balance was poor (<60%). Thus, aryl esters could act as low temperature cross-links in low rank coal. However, there is little data on the formation and pyrolysis of aryl esters at temperatures relevant to those found in the thermal processing of coal (350-425 °C). In this study, we have investigated the pyrolysis benzoic acid in the presence of excess mphenylphenol to study the formation and decomposition of aryl esters, and we have investigated the pyrolysis of phenyl benzoate at 400 °C to determine if aryl esters act as a thermally stable lowtemperature cross-link.


In this paper, we propose a reconstruction-based metric learning method to learn a discriminative distance metric for unconstrained face verification. Unlike conventional metric learning methods, which only consider the label information of training samples and ignore the reconstruction residual information in the learning procedure, we apply a reconstruction criterion to learn a discriminative distance metric. For each training example, the distance metric is learned by enforcing a margin between the interclass sparse reconstruction residual and interclass sparse reconstruction residual, so that the reconstruction residual of training samples can be effectively exploited to compute the between-class and within-class variations. To better use multiple features for distance metric learning, we propose a reconstruction-based multimetric learning method to collaboratively learn multiple distance metrics, one for each feature descriptor, to remove uncorrelated information for recognition. We evaluate our proposed methods on the Labelled Faces in the Wild (LFW) and YouTube face data sets and our experimental results clearly show the superiority of our methods over both previous metric learning methods and several state-of-the-art unconstrained face verification methods.


PURPOSE: An indirubin-3-oxime derivative with an anticancer activity as a cyclin-dependent kinase(CDK) inhibitor is provided to ensure anticancer activity in vivo. CONSTITUTION: An indirubin-3'-oxime derivative compound has an anticancer activity as an CDK inhibitor of general formula I. The general formula I, R1 is F, Cl, OH, or CH_3; and R2 is F, Cl, or NO_2. The indiruvin-3'-oxime derivative of general formula I has an anticancer activity in a lung cancer cell line, fibrosarcoma cell line, human colon cancer cell line, human leukemia cell line, human stomach cancer cell line, or breast cancer cell line. An anticancer composition contains the indiruvin-3'-oxime derivative compound as an active ingredient and pharmaceutically acceptable carrier.


The Dutch Government wishes to participate in peace enforcing missions and stabilizing missions. From the early 1990s onwards, the armed forces have taken part in several of such missions,examples of which are the execution of peace enforcing operations in the Gulf area and peacekeeping missions in former Yugoslavia, Cambodia, Iraq, Ethiopia and Eritrea. Generally, more than a thousand soldiers a year are being deployed. Currently, the armed forces participate in the International Security Assistance Force (ISAF) in Afghanistan. Amongst others, this protracted deployment raises questions as to these troops performance, and whether there are any standards to measure effectiveness and efficiency during missions. The interviewers discussed these questions with Colonel Schaberg and Colonel Stumpers who are both working at Central Staff of the Dutch Ministry of Defense.


The present invention relates to a device for conveying the material web (1), in particular a web made of a web of paper, board, fabric or other slurry. For the web material (1) and preferably the support strip (2) from a first supporting surface (3) to a subsequent supporting surface (4), in a subsequent supporting surface (4) is arranged before the pick-up tank (5) and a stabilizing tank (7), a pickup box (5) having a pick-up region (6) to the material web (1) from the first mentioned support surface (3), stabilizing tank (7) having a stabilizing zone (8) so that web material (1) stable. Suction may be applied to the pick-up area (6) and a stabilizing zone (8) by the vacuum source. The other zone (9) separate from the vacuum pick-up region (6) and a vacuum stabilizing zone (8) is located between the pick-up area (6) and the stabilizing zone (8). Configuration avoids the negative impact on the stability of the vacuum region of the vacuum caused by the pickup area, to avoid the effect of the vacuum pickup area of the vacuum stabilizing zone. The present invention further relates to a method for transferring the web material of the present invention is a device for performing utilized.


In February 1988, the Ministers of Transportation signed a Memorandum of Understanding on Interprovincial Vehicle Weights and Dimensions, marking the culmination of a 15 year long effort of discussion, research, and regulatory development designed to improve the uniformity of regulation across Canada. As a result of this agreement, the trucking industry in Canada has been provided with minimum, nationally accepted standards for vehicle size and weight which apply to a network of highways stretching from coast to coast. The paper describes the background to this initiative and the issues which were addressed. A review of the content and scope of a major research program undertaken in support of the discussions is provided, which included an examination of the influence of size and weight variables on articulated vehicle stability and on pavement response. The key findings of this research are discussed, and their importance to regulatory development reviewed. The means used to incorporate the results of the research program in the development of regulatory principles is discussed, whereby vehicle performance and highway infrastructure impacts were factors in the selection of size and weight limits. The research findings which could not be acted upon in the development of proposed regulatory revisions are also discussed, and the outstanding research needs in these areas reviewed (A).


The Cactaceae is subdivided into three subfamilies (Pereskioideae, Opuntioideae and Cactoideae) which are traditionally interpreted as monophyletic lineages (Barthlott and Hunt 1993). The Cactoideae include 85% of the species diversity in the family and exhibit the greatest morphological extremes in habit and stem structure. This subfamily includes the tribe Cacteae, which is found mainly in and or semiarid habitats in North America and contains the genus Ferocactus Britton and Rose. The taxonomy of the genus remains in a somewhat confused state due to several factors. As for most groups within the Cactaceae, the lack of extensive field research to document variability, the relatively high levels of morphological homoplasy, and the use of primarily vegetative morphological characters, make the establishment of species boundaries difficult. The number of species recognized in the genus has been a matter of disagreement and is reflected in several taxonomic treatments that have been produced over the last seven decades. Britton and Rose (1922) proposed a classification in which they included 30 species; subsequently, Lindsay (1955) proposed that the genus was comprised of 25 species. More recently, Taylor (1984) recognized 23 species, while Bravo and Sanchez-Mejorada (1991) accepted 29. Finally, Unger (1992) presented a classification scheme for 20 species based on the previous treatments. Of these classifications, that of Taylor (1984) represents a systematic treatment of the genus sensu stricto, and is the most widely accepted by cactus taxonomists because it includes detailed descriptions of floral, fruit and seed coat characters. The phylogeny of Ferocactus is uncertain; however, two major evolutionary lineages [section Bisnaga (Orcutt) N. P. Taylor and J. Y. Clark and section Ferocactus] have been proposed for the genus. The former probably derived from F. flavovirens (Scheidw.) Britton and Rose and the latter from F. robustus (Link and Otto) Britton and Rose (Taylor and Clark 1983). These two species are distributed in south-central Mexico, a region that is thought to be the center of origin of the genus (Taylor 1984), and have apparently retained plesiomorphic features that place them as putatively basal species within the genus. On morphological grounds, the two sections are distinguished on the basis of a fruit character: in section Ferocactus the fruits dehisce by a basal pore, and in section Bisnaga the fruits are juicy and indehiscent, occasionally splitting irregularly (Barthlott and Hunt 1993, Taylor 1984). This study was undertaken to document chromosome numbers in Ferocactus and to discuss the causes of its apparently stable diploid condition.


on at least one occasion Dr. Bethune-Baker suggests (in his Girton Conference address), to the revelation in Christ. Broadbased Catholic theology must find God self-manifested through His whole universe, through all human history, but focally, definitively and supremely in Christ, who is thus the crown and criterion of all other revelation. And Dr. Bethune-Baker's own world-view would seem to preclude his adopting any narrower position. A final criticism may be offered. While the Cambridge theologian is insistent that the Pauline affirmation that " the Son of God loved me and gave himself for me" is representative of a characteristic Christian note which must be retained in restatement, he seems occasionally to underestimate the soteriological emphasis in Christian thought. It is because Christ has been Saviour of men that we are interested in the problem of His person; only in so far as He has brought a new quality of life to .men, and made them free of their sense of imperfection and their sin, is He understood to be divine. As a matter of sheer fact it is Christ who has made the parched ground a pool, and the thirsty ground a spring of water. That fact would give Him a quite special place in human history, on any reading. In conclusion, we should acknowledge our indebtedness to Dr. Bethune-Baker's contribution to the restatement of the doctrine of Christ. In this paper we have made a number of criticisms, but that is only because we feel that the work which is criticized is of quite extraordinary value, and points the way for fruitful theological study. Especially important is the insistence on Christ's congruity with -thewhole process of evolution, and His significance as a clue to its nature. For (to use some words of Bishop Chandler) it is only when Christ" appears to us, not as an enigmatic figure suddenly protruded into the midst of a materialistic system ... but as a figure which harmonizes with, and expresses, the true conceptive of Reality," that the full meaning of that concentrated redemptive act of God at one point in revelation-history is apprehended. W. NORMAN PITTENGER.


The use of the phosphazene base P 2 -Et a) as a promoter for the anionic polymerization of hexamethylcyclotrisiloxane (D 3 Me ) or hexaethylcyclotrisiloxane (D 3 Et ) initiated by an organolithium compound leads to well-defined polysiloxanes. At low conversion (< ca. 9%) the polymerization of D 3 Me behaves like a living polymerization, however, polymers with a narrow molecular weight distribution (M W /M n < 1.1) are obtained up to much higher conversions (ca. 70%). Kinetic data and NMR spectroscopy revealed the existence of a dynamic equilibrium between complexed and uncomplexed lithium silanolates. Below ambient temperature several different types of aggregates were indicated. The occurrence of an acceleration was observed after ca. 9% conversion.


Abstract Fourteen of 27 patients being treated with maintenance hemodialysis and 1 staff nurse from the general wards developed hepatitis between August 1966 and April 1967; 1 patient died. Eight o...


The book offers a selection of the author's seminal recent articles, focusing on Jesus, Paul, and questions of principle. It contributes to the Jesus quest by questioning the authenticity of some sayings and stories usually counted to the "bedrock" of the tradition. It analyses the ambiguous relationship of early Christians, especially Paul, to their Jewish heritage. It suggests new ways of handling fundamental questions of principle in biblical interpretation. The book is likely to stimulate thought and discussion, challenging widely held views. The author reflects on the use of New Testament in responsible modern theology, defending classical historical criticism against recent challenges. The emphasis put on the role of experience in the formation of early Christian thought and on the significance of the "effective history" of the Bible is especially helpful.


Adolescent bullying is a public health issue of great global concern. Given the serious negative effect of bullying on adolescent mental health, it is critical to seek protective factors to protect adolescent mental health. From a global cross-regional perspective, the study aims to explore the relationship between forms of bullying and adolescent mental health and the role of parental support as a protective factor. Data were drawn from adolescents aged 12–17 years in 65 countries from the Global School-based Student Health Survey between 2003 and 2015. After controlling the state-fixed effects, individual adolescent behavior, and family factors, the ordinary least squares model was used to analyze the influence of bullying frequency and forms of bullying on adolescent mental health. The results found that the prevalence of bullying in the sample of 167,286 adolescents was 32.03%, with the highest prevalence of bullying in the sample countries in Africa. Verbal bullying had the highest prevalence and the most significant negative effect on adolescent mental health. The study also discussed the differences in bullying among adolescents by gender, age, and region. "Parental supervision", "parental connectedness" and "parental bonding" played a positive and protective role in the mental health of adolescents who experienced bullying.


The invention relates to a system and method for a flutter ground simulation test of an aircraft control surface. The method comprises the steps that random excitation is applied so as to enable a control surface structure (1) to be tested to move; a laser sensor (2) emits X-rays to the control surface structure (1) to be tested, and the local moving speed and the local displacement of the control surface are measured; an aerodynamic force determining device (6) conducts unsteady aerodynamic force calculation according to signals collected by the laser sensor (2), and a loading device (8) is driven to conduct aerodynamic force loading on the control surface structure (1) to be tested. The system and method have the advantages of being simpler, more convenient and easier to do than a conventional air hole test due to the fact that a structure to be test is a real object with proportion of 1:1, maintaining real boundary supporting conditions, being capable of considering dynamic stiffness problem of a steering engine, incapable of bringing additional mass for the system due to the fact that the laser sensor is not in contact with the control surface structure to be tested, greatly simplifying the number and the layout mode of the sensor and shock excitation equipment due to the fact that the aerodynamic force quick calculating system and method are used on the hypothesis of control surface rigidity, and being capable of realizing aerodynamic force calculation in the range of subsonic speed, supersonic velocity and even hypersonic velocity through adjusting an aerodynamic force calculation system and method.


By criterion scaling and principal component analysis of performance, social class, symptoms, institutionalization, and medical history, a cohort of mental defectives has been divided into medical, biological, and sociofamilial categories. This division, corresponding to differences in etiology and severity, reveals changing patterns of admission and provides evidence that male excess is not primarily due to sex linkage. The incidence of mental retardation increases about 5 % with first‐cousin marriage, in agreement with other studies. The decline of IQ with inbreeding appears to be due entirely to rare recessive genes, not to dominance deviations of polygenes.


A structured light-based high-speed detection system and a method for railway fasteners belongs to the technical field of optical detection, and the system comprises: a high-speed camera, a laser source, and a processing system, wherein the laser source and the high-speed camera are respectively disposed at the upper part of a fastener region to be detected, and emit respectively a set of structured light to the region of the fastener; the high-speed camera photographs the image of the fastener region; the high-speed camera is connected to the processing system and the image is transferred; the processing system performs image treatment and determines to obtain the detected results. The invention solves the defects of low identification speed and poor generality in the prior art, is applicable to the on-line rapid detection of railway steel rail fastener loss, and has the advantages of high identification speed, good generality, and strong adaptability.


Wang-Wutang was a loyal and obedient leader of Nuzhen to the Ming Dynasty in the 4th year of Wanli,but in Wanli 7-8 year,their homeland had been damaged by Li-Chengliang because of his invading actions to the Ming Dynasty.During a few years,the direct reason of serious changing is the ethnic oppression and ethnic discrimination that Ming Dynasty imposed upon the Jianzhou Nuzhen;the indirect reason is the greater faults of the Ming Dynasty in the ethnic practice of Liaodong area.The primary cause is the wrong ethnic thought and the wrong ethnic policy of Ming Dynasty.


The utility model discloses a reinforced water draining sound attenuation combination tube. The inner diameter of the tube gradually reduces from top to bottom, so that the whole tube is of a funnel shape. A connecting section for being connected with other tubes or tube stocks is arranged at the upper end of the tube, flow guide ribs are arranged on the inner surface of the tube, and the direction of the flow guide ribs is consistent with the direction of water draining. The direction of the flow guide ribs is designed to be consistent with the direction of water draining, so that when water is drained, the collision area of water flow and the flow guide ribs is far smaller than the collision area of water flow and spiral flow guide ribs in the prior art, noise is effectively reduced, and abrasion to the flow guide ribs can also be effectively reduced.


From a unified point of view, we discuss Birkhoff coordinates of Hamiltonian systems with an external potential including particle-particle interaction owing to N invariant quantities defined in a tangent vector space in autonomous N -dimensional dynamical systems with continuous time. We first consider 2D and 3D billiard systems for a single particle moving under an influence of an arbitrary potential to derive Birkhoff coordinates, and discuss a statistical average of a time between two consecutive collisions against a boundary and a dynamically defined pressure (not a thermodynamical pressure) by assuming that an ergodic measure is realized as a micro-canonical ensemble and moreover almost all trajectories repeat bouncings on the boundary without any trapping by the external potential. We then discuss Birkhoff coordinates for 2D systems for two particles interacting with each other. We also consider 2D and 3D magnetic billiard systems with arbitrary scalar and vector potentials. As illustrative example...


Contents: C.E. Billings, Foreword. R. Amalberti, N.B. Sarter, Introduction: Cognitive Engineering in the Aviation Domain--Opportunities and Challenges. Part I:Frameworks and Models of Human-Automation Coordination and Collaboration. K.M. Corker, Cognitive Models and Control: Human and System Dynamics in Advanced Airspace Operations. V. De Keyser, D. Javaux, Mental Workload and Cognitive Complexity. E. Hollnagel, Modeling the Orderliness of Human Action. M. Leroux, Cognitive Aspects of Automation. Part II:Use(r)-Centered System Design and Training in Support of Joint System Performance. T.S. Abbott, Task-Oriented Display Design: The Case of an Engine-Monitoring Display. J.M. Flach, J. Rasmussen, Cognitive Engineering: Designing for Situation Awareness. P.G.A.M. Jorna, Context Simulation: An Interactive Methodology for User-Centered System Design and Future Operator Behavior Validation. C.M. Mitchell, Horizons in Pilot Training: Desktop Tutoring Systems. J. Paries, R. Amalberti, Aviation Safety Paradigms and Training Implications. M. Plat, R. Amalberti, Experimental Crew Training to Deal With Automation Surprises. J. Reason, A Cognitive Engineering Perspective on Maintenance Errors. D.D. Woods, N.B. Sarter, Learning From Automation Surprises and "Going Sour" Accidents.


Quantum capacities are fundamental quantities that are notoriously hard to compute and can exhibit surprising properties such as superadditivity. Thus, a vast amount of literature is devoted to finding tight and computable bounds on these capacities. We add a new viewpoint by giving operationally motivated bounds on several capacities, including the quantum capacity and private capacity of a quantum channel and the one-way distillable entanglement and private key of a quantum state. These bounds are generally phrased in terms of capacity quantities involving the complementary channel or state. As a tool to obtain these bounds, we discuss partial orders on quantum channels and states, such as the less noisy and the more capable order. Our bounds help to further understand the interplay between different capacities, as they give operational limitations on superadditivity and the difference between capacities in terms of the information-theoretic properties of the complementary channel or state. They can also be used as a new approach towards numerically bounding capacities, as discussed with some examples.


The optical resonance of gold nanoparticles placed at nanometre distances from a gold surface by means of a dielectric spacer was investigated. Different types of molecules, 2-aminoethanethiol and shape-persistent polyphenylene dendrimers were used as spacers and compared. Furthermore, the gold nanoparticle size and the ambient medium were varied. The influence of all these parameters on the resonance wavelength of the system was determined. Based on a simple analytical model, a quantitative analysis was developed and surprisingly good agreement of this model with our experiment without any adjustable parameters was found.


Summary Streptokinase (SK) is a routinely used thrombolytic agent but it is immunogenic and allergenic; staphylokinase (STA) is a potential alternative agent which is under early clinical evaluation. The comparative prevalence of antibodies against recombinant STA (STAR) and against SK was studied in healthy subjects and their induction with intravenous administration in small groups of patients. Enzyme-linked immunosorbent assays, using microtiter plates coated with STAR or SK and calibration with affinospecific human antibodies, revealed 2.1 to 65 μg/ml (median 11 μg/ml) anti-STAR antibodies and 0.9 to 370 μg/ml (median 18 μg/ml) anti-SK antibodies (p <0.001 vs anti-STAR antibodies) in plasma from 100 blood donors, with corresponding values of 0.6 to 100 μg/ml (median 7.1 μg/ml) and 0.4 to 120 μg/ml (median 7.3 μg/ml), respectively, in 104 patients with angina pectoris. Three out of 17 patients with Staphylococcus aureus bacteremia had significantly increased anti-STAR antibody levels (150, 75 and 75 μg/ml), and STAR neutralizing activities (2.2, 3.6 and 4.1 μg STAR neutralized per ml plasma, respectively). In 6 patients with acute myocardial infarction, given 10 mg STAR intravenously over 30 min, median anti-STAR antibody levels were 3.5 μg/ml at baseline, 2.9 μg/ml at 6 to 8 days and 1.2 μg/ml at 2 to 9 weeks, with median corresponding titers of STAR neutralizing activity at 2 to 9 weeks of 42 μg/ml plasma. Conversely, in 5 patients treated with 1,500,000 units SK over 60 min, median anti-SK antibodies increased from 2.9 μg/ml at baseline to 360 μg/ml at 5 to 10 days, with corresponding median SK neutralizing activities of 13 μg/ml. Antibodies against STAR did not cross-react with SK and vice versa. Plasma from human subjects contains low levels of circulating antibodies against recombinant staphylokinase, and intravenous administration of this compound boosts antibody titers. These antibodies do however not cross-react with streptokinase, whereby the use of these two immunogenic thrombolytic agents would not be mutually exclusive.


This paper assessed the factors affecting implementation of community projects At Kimira - Oluch Smallhaolder Farm Improvement Project (KOSFIP) in Homa Bay County, Kenya. Study objectives included assess the factors causing delay in implementation of KOSFIP project; assess the factors causing escalation of costs in implementing KOSFIP project assess the attitude of the community towards KOSFIP project; and assess the effect of community leadership on implementation of KOSFIP project. A case study research design was used to collect data from 3,000 households in the project's area of coverage. The study established that: natural occurrences such as floods and daily coordination of activities were major causes of delay as supported by 57.9% and 56.2% of the respondents respectively. Similarly, demand for compensation and resettlement, mitigation of floods and inflationary fluctuations were the major factors of cost escalation as supported by 59.6%, 49.7% and 57.5% of the respondents respectively. However, there was minimal interference with project implementation from the community as 93.7% of the respondents felt that community members were not a hindering factor. Finally, there was a weak positive linear relationship between local leaders support for implementation of KOSFIP project and their strong belief in handouts as shown by R = 0.421 and reduction in variations of R 2 = 17.8% in implementation of KOSFIP project can be explained by local leaders belief in handouts. Further, the value of t = 5.168 and 6.319 indicates that there was a strong significant positive effect on implementation of KOSFIP project by leaders' belief in handouts. The study is useful to project planners, stakeholders and financiers who are in need of relevant information on factors affecting project implementation. It will also be useful to researchers and scholars who wish to generate more knowledge or fill gaps on implementation of community projects.


There are relatively numerous examples of oral tradition in B. A. Krcelic's Annuae. They spring from historical events - which are their context - from actual events of the time, often witnessed by Krcelic, and an autobiographic discourse is evident in them.


Circularity is clearly a competitive advantage and a market opportunity for European industries. From this perspective, while digitalization is largely recognized as an accelerator and an enabler of Circular Economy, the fact that European industry is strong but fragmented (highly specialized medium- and small-sized companies have different needs and different tools) naturally results in the proliferation of commercial platforms for digitalized manufacturing. If such fragmentation is not properly addressed, it will eventually become a threat to European competitiveness. Despite some examples, value networks still do not operate in a seamless, transparent, and effective way. This paper addresses the challenges and the resulting technical funding pillars for an IDS (International Data Space) manufacturing platform meant to empower a fully digital circular thread of products and services.


A 72 ft aerial being erected with primitive equipment on Campbell Island. Photograph taken in the late 1950s by George Poppleton.
Quantity: 1 colour original transparency/ies.
Physical Description: 35 mm colour slide


The Simplex S^D is the sample space of a D-part composition. There are only a few distributions defined on the Simplex and even fewer defined on the Cartesian product S^D x S^D. Based on the Dirichlet distribution, defined on S^D, we propose a new bicompositional Dirichlet distribution defined on S^D x S^D, and examine some of its properties, such as moments as well as marginal and conditional distributions. The proposed distribution allows for modelling of covariation between compositions without leaving S^D x S^D.


Objective To evaluate the value of color Doppler echocardiography in the diagnosis of atrial septal defect(ASD).Methods The data of 238 cases of atrial septal defect confirmed by surgery were retrospectively analysed.Results 238 cases of ASD was diagnosed by color Doppler echocardiography,in which sinus venosus type in 7 cases,ostium secundum type-in 205 cases,ostum primum defect in 15 cases,mixed type in 10 cases,coronary sinus type in l case.The diagnostic correct rate was 94.96%(226/238).Conclusion Color Doppler echocardiography is a preferred method in the diagnosis of ASD.


Lorentz invariance violation (LIV) manifesting itself by energy-dependent modification of standard relativistic dispersion relation has recently attracted a considerable attention. Ellis et al previously investigated the energy-dependent time offsets in different energy bands on a sample of gamma ray bursts and, assuming standard cosmological model, they found a weak indication for redshift dependence of time delays suggestive of LIV. Going beyond the ΛCDM cosmology we extend this analysis considering also four alternative models of dark energy (quintessence with constant and variable equation of state, Chaplygin gas and braneworld cosmology). It turns out that the effect noted by Ellis et al is also present in those models and is the strongest for quintessence with a variable equation of state.


Programmed cell death (PCD) in tapetum provides nutrients for pollen development. Once this process becomes abnormal, the pollen will be aborted, and sterile lines will be formed. Lycium barbarum L. is a well-known medicinal and edible plant, and male sterile lines play an important role in the cultivation of its new varieties by utilizing hybrid vigor. However, the male sterility mechanism of L. barbarum is poorly understood. In this study, the main characteristic changes during the pollen development of L. barbarum sterile line (Ningqi No. 5) and fertile line (Ningqi No. 1) were compared through anatomical observation, physiological detection and gene expression analysis. Anatomical observation showed that compared with that of the fertile line, the tapetum of the sterile line persisted during pollen development, the organelle morphology and number of tapetal cells changed remarkably, and the PCD was remarkably delayed. Membranous peroxidation caused by reactive oxygen species (ROS) in the sterile line occurred from the late tetrad to the pollen grain stage, and that in Ningqi No. 1 transpired in the tetrad stage. This difference in the dynamic changes of ROS affected the redox balance of microspore development. qPCR detection of DYT1 and MS1 genes regulating tapetum development showed that compared with those in the fertile line, the expression levels of both genes in the sterile line changed significantly from pollen mother cell stage to pollen grain stage. This finding may be associated with the start-up delay of tapetal PCD. All these results suggested that abnormal tapetal PCD is an important mechanism leading to male sterility in L. barbarum.


Nitrogen-doped TiO2 nanopowders were synthesized by homogenization and conventional mechanically stirred technique in DI water media. Different amount of nitrogen was loaded in TiO2 matrix. As-obtained intermediate products were annealed at 100°C for 30, 60 and 120 min. The structural properties of samples were characterized by X-ray diffraction. The absorption spectrum of N-doped TiO2 photocatalyst was analyzed via UV-Vis spectrophotometry. When doping TiO2 with nitrogen, its absorption spectrum is shifted to visible region resulting in the enhancement of photocatalyst properties in dye photodegradation. The photocatalytic activity of TiO2 and Ndoped TiO2 was investigated by the degradation of Rhodamine B dye under visible light.


Nowadays, it is required to apply low observable technology to weapon systems in operation or under development. Radar Cross Section(RCS) is a measure of the scattered power in an given direction when a target is illuminated by an incident wave and used as a parameter to estimate the low observable performance of weapon system. RCS of a target can be calculated by various numerical methods. However, measurement is also needed to estimate RCS of a complex target because it is difficult to estimate theoretically. To acquire reliable measurement results, an analysis of measurement uncertainty is essential. In this paper, error components and uncertainties of near-field RCS measurement system which was constructed in ASTEC(Aerospace System Test & Evaluation Center) were analyzed based on the IEEE recommended practice for radar cross-section test procedures(IEEE Std. 1502-2007) which describes the uncertainty of RCS measurement and unique error components of this near-field measurement system were also identified.


Completed tehnocenose analysis of the structure of production electrical power in the Russian Federation with the H-i-distribution. Shows the relationship of indicators of H-i-distribution of power exports of the Russian Federation.


Professor Constance Backhouse compiles selected statutes to summarize the development of sexual assault law over the past century. She notes that changes to the language, definitions and punishments surrounding rape/sexual assault over the past century reflect changes in attitudes toward women, women's rights, and patriarchal values. The evolution of sexual assault offenses shows a shift in emphasis from the sexual nature of the crime to the violence of sexual assault, and different formulations of how consent factors into sexual crimes.


COPYRIGHT © 2023 Relja, Coldewey, Ghezzi, Martin and Thiemermann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. TYPE Editorial PUBLISHED 25 May 2023 DOI 10.3389/fimmu.2023.1215888


Based on the results of the grounded theory,this paper researches the influencing factors of inter-organizational knowledge sharing under open innovation model empirically.The results indicates that all the four dimensions including environmental variable,sharing channel,demand of knowledge resource and knowledge resource pool have effect on the inter-organizational knowledge sharing.In the meanwhile,the relationships of the influencing factors are interactive and complicated.The conclusions prompt that the enterprise should distinguish the systemic and contact relationship between the influencing factors in the process of acquiring the outside knowledge.Also it is necessary and essential to pay more attention to the dynamic synergy between different upgrading measures of inter-organizational knowledge sharing performance.Finally,some promotion measures of inter-organizational knowledge sharing are put forward,and the further research directions are indicated.


The article deals with the methodological structuring of legal knowledge. It is common practice to specify two types of legal methodology: philosophical and judicial, yet the author demonstrates how new paradigmal parameters of legal metatheory manifest themselves. According to this metatheory, alternative concepts may be of the same order in a metatheoretical sense. The comparison of theoretical and metatheoretical levels of legal knowledge in the framework of three philosophical-scientific paradigms (comparative method) allows philosophy of law to answer the questions: what is law and why there exist multiple variants of legal consciousness. Authors demonstrate why the theme of competition between naturalistic and culture-centered research programs is secondary for legal metatheory and primary for judicial metatheory. The article offers criteria for unambiguous legal consciousness at the theoretical level of legal knowledge and identifies ultimate and reasonable grounds of legal consciousness. The paper concludes that special subdivisions of legal science, legal philosophy represents the paradigmal background of thinking, in the boundaries of which further interpretation schemes of theoretical and empirical levels of knowledge are made possible.


: This paper first analyses the current situation of the development of legalization of ideological and political education, and then analyses the legal literacy education in ideological and political education in colleges and universities in the new era. I hope it can provide useful reference and reference for relevant personnel. First, from the theoretical aspect, it will deepen the theoretical interpretation of the core and spiritual essence of Xi Jinping's rule of law thought. Secondly, from the aspects of fundamental guarantee, subject construction, and goal orientation, it is clarified the value implication of Xi Jinping's thought on the rule of law to cultivate ideological and political education in colleges and universities. The second chapter focuses on the logic of Xi Jinping's rule of law thought to cultivate ideological and political education in colleges and universities. Enrich the rule of law education activities, improve the initiative and enthusiasm of college students, promote college students to better improve their awareness of the rule of law, study practical legal issues in a socialized environment, and achieve the goal of efficiently carrying out rule of law education.


An apparatus for measuring the permeation of a liquid organic compound in a polymer tube is provided. The device includes a flange that is disposed at the open end of the tube and includes a gasket that is suitably secured and seals the liquid organic compound in the tube. An element for filling a tube in the assembly is also disclosed.


1 Senior Consultant, Department of Cardiology, SMIMS, Gangtok, Sikkim 737102 2 Associate Prof., Dept of Cardiology, NRS Medical College & Hospital. Kolkata 3 Associate Professor, Department of Cardiology, Burdwan Medical College and Hospital 4 Professor, Department of Cardiology, Burdwan Medical College and Hospital 5 Department of Cardiology, Senior Consultant Gouri Devi Hospital & Research Institute, Rajbandh, GT Road Durgapur-713212,West Bengal *Corresponding Author Dr Biswarup Mukherjee Email: email@example.com, Phone no. 09874424460 Abstract Background: Coronary artery disease is the leading cause of morbidity and mortality globally. Total thirty one million people are affected by the disease in India. Changing lifestyle, increasing prevalence of diabete , genetic factors may be related to rising incidence of CAD in India, Lack of data on ACS from rural setting prompted authors to study risk factors emerging clinical profile from rural Bengal. Materials and Method: All cases admitted in cardiology ward and ICCU with clinical diagnosis of ACS between Jan 2013 to Dec 2014 at Burdwan Medical College and Hospital were enrolled, Total 2079 patients were included in study, Age .gender. various risk factors, comorbidities, time to delay to thrombolysis or PCI, complication during hospital stay and outcome were analysed. statistical analysis was performed with SPSS programme version 20. Results: mean age of presentation is 58 years with no difference in two communities. hypertension more common in Hindus and diabetes in Muslim group. Older patients received less revascularisation because of co morbidities. 5.5% patients are age less than 40 yrs .most of the ACS patients are in age group 40 to 60 years. we found at least one risk factors in vast majority of young patients and one fourth had one or more risk factors. Conclusion: Acute Coronary Syndrome in rural eastern India tends to present at much younger age Most of the patients presented with with STEMI. Late medical attention, lack of proper referral system leads to late presentation and increased morbidity and mortality.


Objective:To analyse post-traumatic stress disorder(PTSD) and mental health of firemen after earthquake.Methods:A study was performed among 320 firemen in three months after rescue action.All were tested with Post-traumatic Stress Rating Scale(PCL-C) and the Chinese version of Impact of Event Scale(IES-R).Results:The post-disaster PTSD symptoms within three months the overall incidence of 35.3%;5.12 Fire and rescue groups and grass-roots group of IES-R scores were significantly higher than the general institutions group,but 5.12 Fire and rescue groups and grass-roots group of no significant difference in scores,PCL-C scores with similar results;fear,trauma and rescue failed and others are experiencing PTSD symptoms factor.Conclusion:The fireman is the psychological trauma of the high-risk occupational groups,fire and rescue workers after the earthquake a higher rate of PTSD symptoms,should be given a timely psychological intervention.


K-Cl cotransporter 2 (KCC2) maintains a low intracellular Cl concentration required for fast hyperpolarizing responses of neurons to classical inhibitory neurotransmitters aminobutyric acid (GABA) and glycine. Decreased Cl extrusion observed in genetically modified KCC2-deficient mice leads to depolarizing GABA responses, impaired brain inhibition, and as a consequence to epileptic seizures. Identification of mechanisms regulating activity of the SLC12A5 gene, which encodes the KCC2 cotransporter, in normal and pathological conditions is, thus, of extreme importance. Multiple reports have previously elucidated in details a spatio-temporal pattern of KCC2 expression. Among the characteristic features are an exclusive neuronal specificity, a dramatic upregulation during embryonic and early postnatal development, and a significant downregulation by neuronal trauma. Numerous studies confirmed these expressional features, however transcriptional mechanisms predetermining the SLC12A5 gene behaviour are still unknown. The aim of the presented thesis is to recognize such transcriptional mechanisms and, on their basis, to create a transcriptional model that would explain the established SLC12A5 gene behaviour. Up to recently, only one KCC2 transcript has been thought to exist. A particular novelty of the presented work is the identification of two SLC12A5 gene promoters (SLC12A51a and SLC12A5-1b) that produce at least two KCC2 isoforms (KCC2a and KCC2b) differing by their N-terminal parts. Even though a functional Rb assay reveals no significant difference between transport activities of the isoforms, consensus sites for several protein kinases, found in KCC2a but not in KCC2b, imply a distinct kinetic regulation. As a logical continuation, the current work presents a detailed analysis of the KCC2a and KCC2b expression patterns. This analysis shows an exclusively neuron-specific pattern and similar expression levels for both isoforms during embryonic and neonatal development in rodents. During subsequent postnatal development, the KCC2b expression dramatically increases, while KCC2a expression, depending on central nervous system (CNS) area, either remains at the same level or moderately decreases. In an attempt to explain both the neuronal specificity and the distinct expressional kinetics of the KCC2a and KCC2b isoforms during postnatal development, the corresponding SLC12A5-1a and SLC12A5-1b promoters have been subjected to a comprehensive bioinformatical analysis. Binding sites of several transcription factors (TFs), conserved in the mammalian SLC12A5 gene orthologs, have been identified that might shed light on the observed behaviour of the SLC12A5 gene. Possible roles of these TFs in the regulating of the SLC12A5 gene expression have been elucidated in subsequent experiments and are discussed in the current thesis.


For AGU publications, the end of 2013 was a very busy time: Several scientists were appointed to the boards of journals.


Abstract We discuss weak disjointness of homomorphisms of minimal transformation groups and use the techniques involved to deepen our knowledge of the equicontinuous structure relation.


Along with the high speed growth of economy in the process of development in modern city,the problem of urban safety is increasingly important.Therefore,the risk evaluation system of city safety is an urgent task to construct.A new risk evaluation method adapted for economy development and running is provided to build up the evaluation system by the analysis of relationship between the growth of economy and the restriction factors of marginal utility including the control ability of urban emergency and the capacity of city safety.The paper provides a risk evaluation system of city safety based on marginal utility in economy development tightly relevant to the speed of economy growth.Lastly the theoretic mathematic model of risk evaluation is presented.


This study focused on improving the energy conversion of hybrid solar panels and a wind turbine system. The improvement was produced by enhancing the system with a solar tracker and a wind guide. A microcontroller operated the single-axis solar tracker based on a solar elevation database at -6.91N, 107.61E. The wind guide was an Omni Directional Guide Vane (ODGV), designed to support the drag-type Savonius turbine. The ODGV's inside and outside diameters were 540 mm and 1000 mm, respectively. The wind guide had a 30° polar angle between fins and produced a torque of 0.128 Nm at a wind speed of 4 m/s. The solar tracker increased the system performance by 47% and the wind guide by 166%.


When broadband TWTs adopt compound pipe shell process, non-uniformity of transverse magnetic field interferes with electron beam trajectory, making electron beam hard to be focused. In this paper, the reason of the non-uniformity of transverse magnetic field and its interference with electron movement were discussed. And a practical loaded vane structure which could ensure good focusing performance and interaction performance at the same time was proposed.


The electrode impedance of pure aluminum and Al-Zn alloys have been measured at 103 Hz under potentiostatic-cathodic polarization. The cathodic current density for reduction of dissolved oxygen on pure aluminum is smaller than that on Al-Zn alloys, but hydrogen overvoltage for the former is larger than that of the latter. At potentials more noble than the hydrogen evolution potential, the oxygen reduction reaction seems to occur at local cathodes on the electrode and the ratio of the area of local cathodes to the whole surface of the electrode changes with time of polarization. At potentials less noble than the hydrogen evolution potential, the cathodic reduction of oxygen and hydrogen ion proceeds simultaneously and the dissolution of surface oxide films occurs together with the evolution of hydrogen. Under cathodic polarization, the surface of Al-Zn alloys appeared to be black but no significant color change occurs with the surface of pure aluminum. AES analysis showed that the black surface layer contains aluminum, zinc and oxygen with no detectable impurities such as iron and silicon.


This article examines the European Union (EU) energy dependency on Russian resources and focuses on the possible scenarios of shale gas potential in the Baltic Sea Basin. After depicting the extent of energy dependency and setting the scene of the controversial energy dialogue within the umbrella of EU-Russian relations, this article analyses the emblematic energy situation and concerns of the Baltic States. Thereafter, the article exemplifies the increasing sphere of unconventional gas in Europe, once exclusive American prerogative. Hence, the case study of shale gas potentials and prospects in the Baltic Sea Basin directs attention to the peculiarities of the Polish shale. The article is concluded by remarks on the situation at stake and its future perspectives.


The present work is aimed at investigating some important characteristics of standard two-mode laser tubes with internal mirrors of their frequency stabilization and their comparison with the Bulgarian-made He-Ne tube LXH-202M.


Abstract : In October 1994, the tracer gas perfluoro-methyl-cyclohexane (PMCH) was released over a 12-hour period from a location in northwestern France and tracked at 168 sampling locations in 17 countries across Europe (100s of kilometers). This release, known as the European Tracer Experiment (ETEX), resulted in the collection of a wealth of data. IDA has obtained the predictions of 46 transport and dispersion models from 17 countries from the Joint Research Centre, European Commission as well as the PMCH sampling data. This paper applies a previously described user-oriented measure of effectiveness (MOE) methodology to evaluate the predictions of the 46 models against the long-range ETEX observations. The paper extends previous work by computing MOE values that are based on "true" areas (e.g., in square kilometers) and on actual European population distributions. The overall objective of this paper is to document the procedures used to estimate the area-based and population-based MOE values.


Early recovery from trauma exposure in youth is poorly understood. This prospective longitudinal study examined the early course of traumatic stress responses in recently trauma‐exposed youth, evaluated the revised DSM‐5 acute stress disorder (ASD) and PTSD diagnoses and alternative diagnoses, and identified risk factors for persistent traumatic stress.


The study was conducted in Wonchi District, Oromia national regional state, Ethiopia to identify major beekeeping constraints and opportunities. Structured questionnaire was employed for the study. The study used desk research, interviews, surveys and visual observation as methods in seeking answer to research questions. Purposive and simple random sampling techniques were employed to select 70 beekeepers from two Peasants Association. The collected data were analyzed by using SPSS version 20. The result of the study revealed that the average amount of honey harvested /hive/year from traditional hive, transitional hive and modern hive were 5.22±0.042, 10.83±1.05 and 15.2±2.52 respectively. The mean yield obtained from the three hives were statistically significant at (p < 0.05).The most factors influencing honey pricing in the study area were distance from market( 28%), quality of honey (25%), consumers' preference (20%), color (15%), and test of honey (12%).The major constraints to beekeeping activity in the study area were: high cost of modern hives with accessories (1), shortage of bee forage (2), pests and predators (3, poising of bee colonies (4), low quality of honey product (5) and poor infrastructure development (6). Despite of the constraints encountered this sub sector; there are also future opportunities for beekeeping development in the District. These include; presence of huge number of bee colonies, availability of tourists in the area, steadily increasing the demand of local honey, presence of beekeepers association and presence of good government policy. The study revealed that the price of honey in the study area is influenced by quality of honey, color, consumers' preference, distance from market and test of honey. Further study is required to characterize honey bees of the area, and major pests, predators and disease of economic importance.


In recent years, there has been an increased awareness around the world as to mental health risks to children in crisis situations, the COVID-19 pandemic is one example of this. When examining resilience and vulnerability factors amongst children, significant figures such as teachers, parents and friends' reactions will determine the child's ability to cope. Their reactions can provide open spaces for meaningful communication with children while responding to their needs. This may contribute to their resilience and coping skills (Soejima, 2021, Sprang, & Silman, 2013). The purpose of this lecture is to describe a discourse program that teachers used in order to provide emotional support during the pandemic, when conducting dialogue with children. The research method is a discourse analysis of data collected through 30 videos of teachers' conversations with children. The videos were transcribed and then analyzed, using a coding scheme that was developed by the researchers. It was based on a tool designed by Birenbaum et. al., (2004), and adapted to the needs of the study. The findings showed that as teachers created open spaces and allowed for different perspectives to be heard, the children felt free to speak of their family members, the toys they liked to play with as well as family pets and other interests. The interactions were more symmetrical, meaning that one did not dominate the dialogue, leading to active listening and personal responses. In addition, the findings showed that teachers perceptions and beliefs of their role was that of a pedagogical figure, teaching them and having the children learn. It is important to help teachers develop new role perceptions that consist of providing emotional and social support as well as being a pedagogical figure.


The chemical shifts of F/sup 19/ nuclear magnetic resonance in various concentrations of hydrofluoric acid aqueous solutions were measured in order to obtain quantitative data on composition and acidity. It was found that the relation f/sub B//f/sub BH/ + f/sub F/ - 1 holds in the concentration range up to 37 M. (R.V.J.)


we analysed the soret, radiation and chemical reaction effects on laminar convective flow of a dusty viscous fluid of non conducting walls in presence of transverse magnetic field. The governing equations of the flow are solved by Perturbation Technique. Further, the effects of all physical parameters on the velocities of fluid phase and dust phase, temperature and concentration are analysed and discussed through graphs. Key wo rds : Dusty Fluid, Laminar flow, MHD, Chemical Reaction, Soret.


Introduction Cognitive deficits, behavioral disorders, neuropsychiatric symptoms (BNS) are characteristics in Alzheimer's disease (AD). Morover, elderly patients often take multiple medications for their several chronic health conditions. Shared decision making is essential to deprescribing unnecessary or harmful medications in older adults. For these reasons, it may be useful to develop multiple strategies intervention not pharmacologically based and to raise the living standards of the patients, the healthcare professionals and the relatives directly or indirectly involved. Objectives To show application of the Agorà model in AD to improve the performance levels, to decrease the aggressive behaviours and wandering episodes. Methods Twelve inpatients (79-95 ys) affected by AD, were included in our observational study, recruited in Social Cooperative "Il filo di Arianna", We have applied in our patients the Agorà model (from the Gentlecare model).Were administered following scales: in inpatients: NPI; CDR, MMSE; in caregovers: CBI; at baseline (T0), after three (T1), six (T2) twelve months (T3). For statistical evaluation we used the EZAnalyze Version 3.0 software, on Excel. Results At T0 all patients showed high levels of behavioral and aggression disorders. After T3 with Agorà Model, there has been a significant reduction of previous levels. In addition, an improvement in CBI data was observed in caregivers. Conclusions The application of the Agorà model has triggered better performance levels in AD. Moreover, it determined a decrease of behavioural disorders, promoted higher levels of participation in the everyday care activities, improved family wellbeing and participation to the assistance activities, reduced health care professionals turnover and burnout levels. Disclosure No significant relationships.


A new approach to mechanized document retrieval is demonstrated using optical and photoelectric methods to retrieve indexed documents stored on microfilm. Microfilm can be used to store images of documents compactly with suitable index codes recorded on the film adjacent to the image of the document. The film can be passed through a «statistical machine» [microfilm selector] in which a combination of light source, search template, and photoeletric cell is used to scan the moving film, identify the desired index code, project or copy the associated document. The machine demonstrated can search to up to 35,000 documents per hour, which could be increased to 100,000 per hour. [Translation of «Das Registrierproblem in der Photographie», a paper presented at the VIIIth International Congress of Photography, Dresden, 1931, and published in the proceedings in 1932.]


The sensor localization is an essential function for the wireless sensor networks applications. Based on the characteristics of the DV-hop algorithm, an improved algorithm is proposed for this range-free localization algorithm. The main principle of the proposed algorithm is giving more consideration on network topology properties and making improved hop size estimation through proper tradeoff between network's global and local features. The results of the simulation experiment show its superiority in localization accuracy.


In this paper, we propose a real-time human-robot interface (HRI) system, where Electrooculography (EOG) and Electromyography (EMG) signals were decoded to perform reach-to-grasp movements. For that, five different eye movements (up, down, left, right and rest) were classified in real-time and translated into commands to steer an industrial robot (UR-10) to one of the four approximate target directions. Thereafter, EMG signals were decoded to perform the grasping task using an attached gripper to the UR-10 robot arm. The proposed system was tested offline on three different healthy subjects, and mean validation accuracy of 93.62% and 99.50% were obtained across the three subjects for EOG and EMG decoding, respectively. Furthermore, the system was successfully tested in real-time with one subject, and mean online accuracy of 91.66% and 100% were achieved for EOG and EMG decoding, respectively. Our results obtained by combining real-time decoding of EOG and EMG signals for robot control show overall the potential of this approach to develop powerful and less complex HRI systems. Overall, this work provides a proof-of-concept for successful real-time control of robot arms using EMG and EOG signals, paving the way for the development of more dexterous and human-controlled assistive devices.


A model scale investigation of tiltrotor/obstacle aerodynamic interactions under zero wind conditions was conducted in the winter of 2022 by Bihrle Applied Research, Inc. (BAR) and LaVision, Inc. on behalf of NAVAIR. The test was conducted at 6% scale in a closed test hall with a full-span tiltrotor and an obstacle representing the aft portion of an amphibious class ship. The test objectives were to quantify the impact of recirculation on aircraft performance and trim as a function of aircraft position and orientation relative to the obstacle, and to acquire velocity flow field measurements for analysis validation and empirical model development. Principal data acquired include the force and moment reaction of the aircraft rotors and airframe, dynamic surface pressures on the obstacle, and particle tracking velocimetry (PTV) measurements of the flow field. This paper provides an overview of the test approach and execution and a presentation of selected results illustrating the variation of recirculation impacts with position and orientation relative to the ship obstacle.


ABSTRACT Based on the PRISMA approach, this article presents a systematic review of how barriers and governance strategies are different between digital and non-digital open innovation (OI). The results show that relational barriers are more influential for non-digital OI, while capacity- and technical-related barriers are the main challenges for digital OI. Moreover, it finds that political commitment and employment of intermediaries are universal strategies for OI. Coercive and mandate strategies are effective only for inter-governmental OI. When citizens and private actors participate offline, strategies are often persuasive-oriented and stress relational governance; when they participate online, strategies focus on technical capacity building.


This paper describes the initial establishment of a business-to-business network in a novel context - within and around a government department as it implements Purchaser-Provider relationships. A popular reform in public sector management over recent years has been the establishment of internal competition to increase efficiency and effectiveness under a "Purchaser-Provider" model. We applied the International and Industrial Marketing Purchasing (IMP) framework to capture some of the major transitions occurring within and around this organisation. We found the IMP approach useful for capturing the dynamic emerging structures. Just like relationships in private-sector business, Purchaser-Provider tends to operate as a network, with a mix of cooperation and competition, rather than competition alone. The public-sector context is unusual in that the network has been established by moving from an administrative control structure, cooperation alone, rather than from an open market, with competition alone. Implications for further research are raised.


In these timeless and witty essays George Orwell explores the English love of reading about a good murder in the papers (and laments the passing of the heyday of the 'perfect' murder involving class, sex and poisoning), as well as unfolding his trenchant views on everything from boys' weeklies to naughty seaside postcards.


Based on the speech transfer and speech perception theory,the paper presents an experimental analysis of the perception of RP English monophthongs by the non-English majors.The results reveal that due to the transfer of native-language prototype category,the prototype-like English vowels have the lowest error rate and have a tendency of assimilating other vowels,causing perception errors of these vowels.There is no significant difference between genders in terms of the vowels perception.These findings have implications for the teaching of English phonetics and oral English.


As part of project Optimize a five-year human papillomavirus (HPV) vaccine demonstration project is under way in Uganda and three other countries to demonstrate how existing health systems can be adapted to successfully provide HPV vaccine to young adolescent girls. HPV vaccine is a strong candidate for storage and transport in a controlled temperature chain at temperatures higher than the standard 2o to 8oC cold chain storage.