text:
motion it's quite a sight, this hurtling metal cylinder
of red, white, yellow and blue, tricked out with team
logos from bow to stern, shuttling its heroic cargo
from rink to rink and state to state. Making a getaway
from an opposing arena it becomes a moving target, weathering
a fusillade of jeers, curses and obscene gestures, anything
short of rotten fruit. Sometimes, a spirited group of
young women will come into view, happy to greet the
bus' occupants with a smile, a wink, a patch of flesh
-- and not just midriff. Mostly though, the Bat Bus
spends six months and too many days in a row passing
through the middle of nowhere, only to arrive in a place
that barely meets the definition of somewhere.
All of that,
however, is when the bus is moving. Right now, it isn't
going anywhere. It's October. It's 4:30 a.m. Nine hours
earlier the puck dropped in Lake Charles, Louisiana,
marking the first exhibition game of the season, Ice
Bats vs. Ice Pirates. Five hours earlier 20 hockey players
hit the Players Island Casino dinner buffet, possibly
the nicest road meal in minor league history. A few
of them scored pre-season bonuses at the blackjack table.
Now everyone's
asleep, oblivious to the fact that the bus has been
sputtering along at 20 miles per hour the last couple
of miles. Finally, it whinnies to a halt at the side
of a rainsoaked two-lane highway in Ellinger, Texas.
274 citizens strong, Ellinger is a country town that
has escaped development, just a dot on the map between
Austin and Houston to most folks.
The groggy souls
who notice the stoppage in play chalk it up to the driver's
tiny bladder, or his jones for coffee, or both. No need
to dwell on the way he wanders around the well-lit but
unmanned Texaco station without any purpose. Surely
it's too soon to wonder how many cabs might have to
travel from Austin -- nearly two hours northwest of
here -- to get everyone home.
Guys wander
off the bus. Ellinger's entire retail district -- pretty
much all of Ellinger, in fact -- lies before them. But
neither the Texaco nor Hruska's Instant Shopping across
the parking lot is available for relief or sustenance.
A nearby puddle does the trick for the former. The scent
of frying bacon suggests the latter will be ready when
the convenience store greets its early-rising farmer
clientele with biscuits and breakfast sandwiches at
five o-clock.
The Ice Bats
can wait until then. They aren't going anywhere.
Brian Fairfield
believes otherwise. He's already under the bus, tinkering.
"I like this
guy," Chris Morque, a returning veteran who will captain
this Ice Bats squad, says of the 19-year-old rookie
netminder. "He can stop the puck, and he can tell us
what's wrong with the bus."
Freckled and
strawberry blond, with a face that's destined to get
carded well past 40, Fairfield is, quite literally,
fresh off the family farm in Omemee, Ontario.
It took about
two seconds for the boys on the bus to saddle Fairfield
with the nickname "Tex" -- the youngster showed up in
Austin ready to two-step, already outfitted with the
hat, the neatly pressed Wranglers and a couple of fancy
western shirts.
Tonight's vestment
is fancy enough that Fairfield peels it off before embarking
on his mud-splattered journey to the innards of the
bus. The driver lays out triangular hazard markers,
wielding a flashlight while the goalie does the real
"Get out from
under there before you get your country ass run over!"
someone shouts.
But Fairfield
knows what he's doing. On the farm, when he wasn't delivering
calves and such, he messed about with tractors and plows.
He understands the workings of a diesel engine.
"If he gets
us out of here, he makes the team," medical trainer
Eric Seeber suggests.
Breakdowns are
a bummer, but the Bats are not particularly fazed by
their predicament. Rookie Jason Rapcewicz rode a train
from Hamilton for 40 hours to get a tryout -- he is,
as the cliche goes, just happy to be here. Chris Morque
has been here, more times than he can remember. When
he and Andy Ross and Mike Jackson played for the Memphis
River Kings, their bus would fritz out after a couple
of hours and the players would hitchhike back to the
city they came from, setting up camp in the lobby of
the hotel they'd just checked out of -- the team wasn't
about to spring for another night of rooms.
And while it
might be wet, it's still 60 degrees. The last time Tim
Findlay had to wait around for roadside assistance he
was in Sudbury, Ontario, where a February night at 30
below might be considered idyllic. A hotshot sniper
for the Windsor Spitfires of the junior Ontario Hockey
League, Findlay arrived in Austin this morning from
Detroit, where he spent four weeks with the Vipers of
the International League, the best league you can be
in if you're not surefire NHL material. The Vipers wanted
to stash Findlay with their AA team in Flint, Michigan,
but neither the warm fuzzy feeling Flint has had ever
since the movie "Roger and Me" nor the exciting prospect
of 10-hour bus rides to Thunder Bay were enough to keep
him there when Ice Bats coach Jim Burton called. Also,
Findlay's best friend and former Windsor teammate Ryan
Pawluk is on Austin's roster.
Findlay's WPHL
career is just three hours old, but he already wants
to know who won the scoring title last season. Told
the answer -- Chris Brooks, with 45 goals and 65 assists
for the Amarillo Rattlers -- the rookie, who found tonight's
action to be a little slow but also chippy enough that
he plans to wear a visor in future games, nods calmly.
"I'll have to take a run at that," he swaggers.
By now it's
6 a.m. Brian Fairfield has figured out what the driver
probably knew all along but didn't want to confess.
The bus is out of gas. And with diesel engines you can't
just fill 'er up.
If one more
thing could go wrong, it would be this -- at 6:35 the
rain begins to fall again, hard. Fortunately, the back-up
bus lumbers down Highway 71 at that very moment. The
players drag their gear onto the new bus, and 10 minutes
later, as the sights of LaGrange (former home of the
Chicken Ranch, a.k.a. the Best Little Whorehouse in
Texas) fly by, the sun is up and the Bats are back to
So -- first
day of the season, new team, new coach, new bus -- it's
a good thing hockey players aren't superstitious! Jim
Burton tries to put an optimistic spin on the ordeal.
"This is a good
sign," the coach reasons, displaying a glass-half-full
optimism that should serve him well in certain post-game
interviews situations. "It means it won't happen again."
The team pulls
into the parking lot of the Chaparral Ice Center at
8 a.m., just in time for morning traffic. Practice is
in four hours.
The bus had
left for Lake Charles the previous morning at 11:05
a.m., which for the Ice Bats is a remarkably accurate
approximation of 11.
Not for the
first time, Burton expresses his amazement at Gunner
Garrett, the team's equipment manager, who occupies
the first row on the left. He's seen Gunner do his thing
a million times, but this is his first close-up look.
What Gunner
does is sleep. Sitting up, head back, pillow between
his face and the window, he sleeps and sleeps and sleeps
and sleeps. If the trip is three hours long, Gunner
needs three hours of sleep. If it's 10 hours long, Gunner
can stay unconscious for the duration. If the bus stops
for lunch Gunner will wake up, eat and konk back out
without warning. When an older player tries to tease
him about it, Gunner is quick to strike back. "I sleep
for five hours on the bus. You sleep for three hours
after we get to the rink," he says. Besides, the 55-year-old
former goalie earns his naps with all those late nights
and early mornings, doing laundry and maintaining sticks
and skates. "This bus will add 10 years to my life,"
Gunner speculates before nodding off. "It has seat belts,
so I won't slide forward."
Burty wonders
out loud if it's okay for him to use the aisle seat
in Gunner's row as a footrest.
"I did that
all the time," Stoughton says, "but he always pushed
me away when my feet got too close to his crotch."
Around 2 p.m.
the bus stops in Houston for lunch, settling on a versatile
suburban strip on the west side of town that features
a Pappadeaux's, a Pappasito's, a Fuddrucker's and a
Macaroni Grill. Most guys opt for the latter establishment,
pasta carbo-loading being the pre-game ritual of choice
for most. The waiter brings out a basket of bread with
a plate of olive oil for heart-healthy dipping. "You
don't see that in Peterborough," Jay Hutton says, before
discovering that he doesn't care for the taste of olive
oil. Kyle Haviland does -- he ends up pigging out on
the bread before his salad and spaghetti come. Another
player might worry that he'd lose a step during the
game, but Haviland is a tough, immobile crease-clearing
defenseman and enforcer. He doesn't have a step to lose.
Andy Ross ends
up at Fuddrucker's, where he enjoyed a nice plate of
lemon pepper chicken. This information is made public
because "Roscoe" -- the nickname goes all the way back
to the "Dukes of Hazzard" -- has been getting teased
about his diet since he showed up in the morning with
a bag full of McDonald's.
"Wait, Roscoe
needs some potato chips," Stoughton had cracked when
the bus stopped at a convenience store. The truth is
Stoughton and Burton have been pleased with Ross's training
camp conditioning so far, but because he's a smoker,
and has been known to enjoy a libation or two, they
ride him hard. They understand him all too well. Burton
happens to be the other guy pacing outside the bus when
it's time to light up, and there's little doubt that
when Stoughton was in the NHL he was also a "play hard,
play hard" kind of guy. When Stoughton was in the NHL,
everyone was.
By the time
lunch is finished it's 3:30 p.m. and the bus is on the
wrong side of Houston, right in time for early rush
hour. Thanks to the ensuing traffic jam the team is
still at least 60 minutes away from Lake Charles . .
. at 5:30.
"We're playing
tomorrow, right?" asks Gunner, who has woken up to navigate.
In fact, not
only is the game tonight, it's at 7, not 7:30. The Ice
Bats are comically late.
At 6:20 the
bus whizzes past the oil refineries and into downtown
Lake Charles, which consists of two neon pink-and-teal-colored
casino boats and one generic shiny glass building. It's
a muggy, 65-degree night, but outside the arena a group
of kids are playing in a pile of snow -- the telltale
sign of a nearby Zamboni. The players change into their
khakis and golf shirts on the bus. They're supposed
to be out on the ice for warm-ups, sticks bent and taped,
skates sharpened, pads and sweaters on, in just 10 minutes.
"Don't ever
touch those cases," Gunner tells the bus driver when
he attempts to offload some gear. "I got the rookies
for that." The rookies aren't quite sure what to make
of the Gun Man yet -- he maintains a gruff, laconic
demeanor that puts the fear of God in them if they do
the wrong thing. "I don't carry skates son, I just sharpen
them," he tells one naif. And: "If you don't put your
sticks in the right place, you can take 'em to the bench
Tonight's game
is fairly meaningless, but there is a subplot, and its
name is Bobby Wallwork. Wallwork was the Ice Bats' player
assistant and leading goal-scorer last year, but, after
some fractious and mutually bullheaded negotiations
with Stoughton, he fled for Lake Charles, where the
team also got him started on a real estate career. Some
of his closest friends are Ice Bats. Many of them played
together before in Memphis and Muskegon, Michigan. Wallwork
was the guy who brought everyone together in Texas for
the inaugural season.
When the bus
pulls in, "Wally" is waiting. He has a hug for Ryan
Anderson and happily braces himself for Gunner's greeting.
"Just what I thought: afraid to play," Garrett says,
eyeing Wallwork's street clothes. In fact, Lake Charles
is sitting seven of its best players tonight so they
can give the ice time to less proven commodities. Before
returning to his new team's locker room, Wallwork makes
sure his buddies realize exactly how little he misses
Austin. "Check out the talent in the stands," he gloats,
gesturing at the wide assortment of exotically beautiful
Louisiana gals.
This will be
the first night of hockey for Lake Charles and its civic
center. The game isn't even open to the public, just
boosters, advertisers, corporate sponsors and other
local dignitaries. Sixty-five miles away in Lafayette
the East Coast League team draws 10,000 people a night,
so hopes are high for this market. The visiting locker
room isn't finished -- the lavatory consists of two
toilets, sitting there wide open like some sort of conversation
pit -- and the home team doesn't have its uniforms.
Most of the players wear plain yellow or white jerseys,
but there are more training-camp aspirants than shirts,
so a few guys sport generic "NHL" practice sweaters.
While the players
guzzle Powerade, Jim Burton puts on a sports coat and
ponders who to start in goal. As the incumbent, Chad
Erickson assumed he would get the initial minutes, but
that does not turn out to be the case. Erickson tells
Burty that advance notice would be appreciated next
"Goalies like
to know," he explains.
Burton, half
grudgingly and half sincerely, invites Chad to help
him out with any other useful pointers.
"Rookie coaches,"
Erickson grumbles. "Gotta break 'em in."
The team quiets
down for Burton's first official locker room address.
"There's two
things I dislike," he says. "One is negative talk --
backstabbing, complaining on the bench. The other is,
you can't play for me if you're lazy out there. You
don't have to go retarded all the time, but don't be
lazy. Short shifts. Have fun.
"And if you
wanna show me something," he adds, referring to the
rough stuff, "show me in the third."
Exhibition game
rules state that if you fight twice, you're automatically
ejected. But fighting is pretty much what the night's
about, much to the delight of the crowd. "You ain't
got no crazy @#$% like us in Texas!" says Brad Downs,
a slightly tipsy fan who leads "Let's Go Ice Pirates"
cheers all night.
"I'm trying
to pump 'em up," Downs explains, adding that he thinks
the fights are the best part.
"We like the
fights," Brad's friend Beau Diamond clarifies, "because
we don't know the damn rules."
That will come
in time. When Kyle Haviland uncorks a slapper that sends
the blade of his stick flying over the crossbar, Gunner
can be seen explaining to a bench-side fan how the stick's
construction makes that possible. And between periods,
the Pirates put on a demonstration of how icing works.
Tonight there
is more fighting than icing. Over the course of the
evening, seven different Bats drop the gloves, including
Rapcewicz, who'd been taken aside by Burton before the
game and told to stir it up at least once.
"Scrapsy" also
scores a goal, but that's of little consequence compared
to his skirmish, an ill-tempered, verbiage-rich tiff
that leaves onlooker Ryan Anderson chuckling appreciatively,
as if he was remembering a long-ago time when he too
was prone to such youthful indiscretions.
Anderson gets
his turn, though. In the third an Ice Pirate calls him
out with this simple taunt: "All you Western Canada
boys are (wussies)."
"So I went after
him," Anderson says. "I'd be lying if I said I didn't
enjoy it."
Brian Fairfield
plays well between the pipes. His counterpart Erickson
does not, much to the amusement of his teammates. But
the veteran goalie is happy to play along. "I handled
it like a girl," he says of a textbook wraparound chance,
joking that he let it by on purpose so the aspiring
Ice Pirate who took the shot would have a better chance
to make the team.
Mike "Jake"
Jackson also has a big night, earning himself the old
"Gordie Howe hat trick" -- a goal, an assist and a fight.
But the stars of the evening are Jake's new linemates,
who each lit the lamp, while also assisting on his score.
"Those two kids that just came -- number 8 and number
9," Anderson says, referring to Findlay and Pawluk.
"They're gonna be great players. I don't even know their
Copyright 2001,
Greystone Books, Canada.


text:
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subset: commoncrawl


text: Home Run! by alemwp published on 2012-10-18T20:32:37Z Genre Homage to Yonas Comment by alemwp @carolb123: Glad to know that! 2013/04/20 01:25:31 +0000 Comment by Carolyn Burnette @alemwp: still sounds good today :) 2013/04/19 14:08:01 +0000 Comment by alemwp @kscotsparks: Thanks! ;-} 2013/01/03 18:07:59 +0000 Comment by kssJAZZMALPRACTICE ooo 2013/01/03 04:41:48 +0000 Comment by alemwp @bjp-1: Hey Brian! Thanks for the fave and the praise! 2012/12/30 23:58:27 +0000 Comment by BJP awesome performed Curt, <3 2012/12/30 02:55:10 +0000 Comment by alemwp @milanazilnik: Hey thanks Milana! I'm glad you enjoy this! I sometimes worry I am repeating things, but then having a style feels nice! Thanks also for the faves! 2012/12/28 22:11:58 +0000 Comment by Milana Zilnik Gorgeous sax over this wonderful relaxing rhythm :) You really have your own style Curt :) 2012/12/28 19:10:08 +0000 Comment by alemwp @nakfa: Yekeniley True story! Thanks for listening! 2012/12/18 02:19:46 +0000 Comment by alemwp @bound-until-death: Thanks for stopping back for another visit! 2012/11/25 03:00:43 +0000 Comment by Bound Until Death WOW Amazing tracks here friend. Nice workz mate 2012/11/25 02:11:59 +0000 Comment by alemwp @ltek: Hey Luke! Thanks so much for the visit and comment! Thanks also for the fave! I have not made a visit to your page for a while! I'll be doing that this week! Thanks! 2012/11/18 16:05:53 +0000 Comment by L-Tek™ really light/happy tune mate. lovely story too 2012/11/18 15:32:22 +0000 Comment by alemwp @terra-vox: This is a factory preset on my Ensoniq MR-61. Thanks, it worked well. Glad you like it too! 2012/11/17 00:55:51 +0000 Comment by THALYNX I like the rhythm section of this piece. 2012/11/17 00:05:07 +0000 Comment by alemwp @bound-until-death: Thanks! And thanks for the fave! ;-} 2012/11/11 17:14:56 +0000 Comment by alemwp @rothwhyler: Wow! That is my main intention, it is nice to read this feedback! Thanks! 2012/11/11 17:13:22 +0000 Comment by Bound Until Death D.O.P.E 2012/11/11 10:08:17 +0000 Comment by alemwp @beat4poets: Hey Jorn! Thanks so much for your kind words! I just can resist that funky music! 2012/11/06 14:07:51 +0000 Comment by beat4poets floating solo lines... funky beat... great to listen to... 2012/11/06 08:20:55 +0000 Comment by alemwp @ecstasyoffumbling: Thanks so much David! Someday I'm going to have to get out my guitar. Your taking the blame piece is so pure and warm! Inspirational! 2012/10/26 19:35:33 +0000 Comment by DAVID AUGUSTIN a real brainworm of a melody...really gets under the skin..excellent curt, and great backstory..good man ! 2012/10/26 17:30:06 +0000 Comment by alemwp @manasseh-monu: Hey thanks Monu! It pleases me that you are enjoying this piece. Thanks also for the fave! 2012/10/25 13:54:22 +0000 Comment by - MONU - nice chill tune and bassline :) 2012/10/25 01:12:08 +0000 Comment by alemwp @decy-14: This sax is a factory sample on my Ensoniq MR-61. Thanks for the visit here! Glad you like the sound! 2012/10/23 18:53:52 +0000 Comment by deezyy nice saxoo ,) 2012/10/23 18:49:36 +0000 Comment by alemwp @rtefive: Hey Rob! Life is full of surprises! Thanks so much for your kind words and the fave! 2012/10/21 04:29:26 +0000 Comment by Rob Simpson excellent composition Curt and very interesting story...a pat on the back from me mate...great work!!! (♥5♥) 2012/10/20 22:35:18 +0000 Comment by alemwp @oystein-jorgensen: Hey Oystein! Thanks ;-} 2012/10/19 13:54:53 +0000 Comment by Øystein Jørgensen ( Q ) wonderful track Curt 2012/10/19 10:25:01 +0000


text:
Vioxx (rofecoxib) was the second drug of its kind to enter the United States market, directly competing with Celebrex, manufactured by Monsanto and co-marketed by Pfizer Inc. and touted as the second-most-prescribed arthritis drug at the time. Merck introduced Vioxx as a part of a relatively new class of drugs known as COX-2 selective NSAIDs or COX-2 inhibitors, which boasted fewer gastrointestinal adverse effects than nonselective NSAIDs, such as ibuprofen.
Vioxx soared as one of the leading agents in providing patients with relief from the painful and bothersome symptoms of arthritis, including pauciarticular and polyarticular Juvenile Rheumatoid Arthritis (JRA). It was widely prescribed, used by millions worldwide and brought in billions of dollars in profits for Merck. So when new evidence surfaced that pointed to a new potential medical benefit of COX-2 inhibitors in the presumed elimination of colorectal polyps and prevention of colon cancer in individuals predisposed to develop such polyps, Merck launched an Adenomatous Polyp Prevention on Vioxx (APPROVe) trial to test the theory.
This study brought about some bad news for Merck. Results from the trial led to findings of increased risk of cardiovascular events, including heart attack and stroke, in patients taking Vioxx, especially for those taking it for more than 18 months, compared to those taking a placebo. Today, many scientists and academics continue to debate whether COX-2 inhibitors go easier on the gastrointestinal tract while actually putting patients' heart health at increased jeopardy.
With estimates of Americans affected by Vioxx ranging from 88,000 to 139,000, and about 30 to 40 percent of those numbers likely resulting in death, FDA Investigator Dr. David Graham described the episode as "a disaster;" one that is "unparalleled in the history of the United States" and that "constituted an unprecedented failure of the nation's system of drug approval and oversight."
However, top FDA official Dr. Sandra Kweder argued against Graham's calculations pointing out that those estimated deaths "are not real deaths," but rather based on data, "something you figure out on a spreadsheet." Kweder also asserted that Graham's assessment failed to recognize the benefits of Vioxx, such as it being the only NSAID offering a true gastrointestinal safety benefit. In fact, Merck's Chief Executive Officer (CEO) Ray Gilmartin said he wholeheartedly believed in Vioxx, even having his wife take Vioxx up until the day it was withdrawn from the market.
Selective Versus Nonselective NSAIDs
The claim that drugs in the COX-2 inhibitor class are less likely than their counterparts to cause severe gastrointestinal problems (such as bleeding) is due to the "selectivity" of the drug in only blocking the one form of cyclooxygenase responsible for pain and inflammation and not the second form, which is thought to actually help protect the stomach from ulcers.
Aspirin and ibuprofen, also belonging to the NSAID class of drugs, are nonselective; meaning they relieve pain by blocking the production of pain-signaling molecules, specifically called cyclooxygenase (COX) enzymes, both types 1 and 2.
NSAID Fact
Nonselective NSAIDs block the production of pain-signaling molecules to relieve pain.
When blocking the COX-2 type, patients will experience relief from pain felt in joints, muscles and other soft tissues. However, the COX-1 type, which is also blocked by nonselective NSAIDs, plays an important role in protecting the stomach lining. By blocking this type of enzyme, nonselective NSAIDs consequently increase the risk of stomach ulcers and gastrointestinal bleeding.
Conversely, selective NSAIDs work to avoid the adverse gastrointestinal effects by only blocking the COX-2 type. This primary benefit set NSAIDs like Vioxx and Celebrex apart from others, and thereby assisted in increased consumer interest and sales.
What Does Vioxx Treat?
Vioxx was a prescription medication used to relieve signs and symptoms of arthritis, acute pain in adults and painful menstrual cycles.
FDA – Approved Vioxx Uses:
- Relief of the signs and symptoms of osteoarthritis
- Relief of the signs and symptoms of rheumatoid arthritis in adults
- Relief of the signs and symptoms of pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older and who weigh 10 kg (22 lbs.) or more
- Management of acute pain in adults
- Treatment of primary dysmenorrhea
- Acute treatment of migraine attacks with or without aura in adults
The safety and effectiveness of Vioxx were not established for cluster headache, which is present in an older, predominantly male, population. It was not recommended to be given to patients who had experienced asthma or urticarial or allergic-type reactions after taking aspirin or other NSAIDs. Additionally, Vioxx was not studied in children less than two-years-old or with a body weight less than 10 kg (22 lbs.).
Vioxx Dosages
Vioxx was administered orally. The lowest dose of Vioxx was recommended for each patient and was to be taken exactly as prescribed by a doctor. The dose depended on the condition being treated and other medical problems. Patients were advised not to change the dose of Vioxx or take extra doses unless told to do so by a doctor. Vioxx was to be taken with or without food.
The recommended starting dose of Vioxx was 12.5 mg once daily. Some patients received additional benefit by increasing the dose to 25 mg once daily. The maximum recommended daily dose was 25 mg.
Rheumatoid Arthritis
The recommended dose was 25 mg once daily. The maximum recommended daily dose was 25 mg.
Pauciarticular and Polyarticular Course Juvenile Rheumatoid Arthritis
|Pediatric Patients
|Daily Dose
|≥ 2 years to ≤ 11 years of age and ≥ 10 to < 42 kg
|0.6 mg/kg to a maximum of 25 mg*
|≥ 2 years to ≤ 11 years of age and ≥ 42 kg
|25 mg
|≥ 12 years to ≤ 17 years of age
|25 mg
*Oral suspension dosage form was recommended. To improve dosing accuracy in smaller weight children, the use of 12.5 mg/5 mL oral suspension (2.5 mg/mL) was recommended.
Acute Pain and Primary Dysmenorrhea
The recommended dose of Vioxx was 50 mg once daily. The maximum recommended daily dose was 50 mg. Use of Vioxx for more than five days in management of pain was not studied, and chronic use of Vioxx 50 mg daily was not recommended.
Migraine with or without aura
The recommended starting dose of Vioxx was 25 mg once daily. Some patients received additional benefit with 50 mg as compared to 25 mg. The maximum recommended daily dose was 50 mg. The safety of treating more than five migraine attacks in any given month was not established, and chronic daily use of Vioxx for the acute treatment of migraine was not recommended.
Hepatic Insufficiency
Because of significant increases in both AUC and Cmax in patients with moderate hepatic impairment (Child-Pugh score: 7 – 9), the maximum recommended chronic daily dose was 12.5 mg. The efficacy of 12.5 mg in rheumatoid arthritis patients with moderate hepatic insufficiency was not studied.
Oral Suspension
Vioxx Oral Suspension 12.5 mg/5 mL could be substituted for Vioxx Tablets 12.5 or 25 mg, respectively, in any of the above indications.
No overdoses of Vioxx were reported during clinical trials. Administration of single doses of 1000 mg of Vioxx to six healthy volunteers and multiple doses of 250 mg/day for 14 days to 75 healthy volunteers did not result in serious toxicity.
Side Effects of Vioxx
Studies showed that patients taking Vioxx were at greater risk of heart attack and other cardiovascular problems than those taking older pain reliever alternatives, such as ibuprofen or naproxen, or those not taking any painkillers.
Common Side Effects:
- Respiratory infections
- Headache
- Dizziness
- Diarrhea
- Nausea, vomiting and upset stomach
- Heartburn
- Stomach pain
- Swelling of the legs and/or feet
- High blood pressure
- Back pain
- Tiredness
- Urinary tract infection
Serious Side Effects:
- Serious stomach problems, such as stomach and intestinal bleeding
- Serious allergic reactions, including swelling of the face, lips, tongue; trouble breathing such as chest tightness or shortness of breath; trouble swallowing; hives; wheezing; or shock (loss of blood pressure and consciousness)
- Heart attacks and other serious cardiovascular events, such as blood clots
- Serious kidney problems, including acute (sudden) kidney failure and worsening of chronic kidney failure
- Severe liver problems, including hepatitis, jaundice and liver failure
Drug Interactions
Vioxx and certain other medicines (including nonprescription medicines) had the ability to affect each other, causing serious side effects.
Warfarin (Coumadin®)
Or any other similar blood thinner used within the past 10 days can increase risk of bleeding complications. Anticoagulant activity should be monitored. Bleeding events reported primarily in the elderly in association with increases in prothrombin time
A medicine used to treat asthma may increase plasma theophylline concentrations. This data means that rofecoxib may produce a modest inhibition of cytochrome P450 (CYP) 1A2 resulting in the potential for an interaction with other drugs metabolized by CYP 1A2, including amitriptyline, tacrine and zileuton
An antibiotic that is a potent inducer of hepatic metabolism. May decrease rofecoxib plasma concentration (effectiveness)
ACE inhibitors
Medicines used for high blood pressure and heart failure may diminish the antihypertensive effect of Angiotensin Converting Enzyme (ACE) inhibitors
A medicine used to treat a certain type of depression may result in an increase in plasma lithium levels
Merck's Shaky History with Vioxx
Merck jumped into the market with Vioxx in hopes of securing a new winning product to make up for its projected decline in revenues that would inevitably come with the expiration of patent protection on four of its drugs bringing in total annual sales of approximately $5 billion. Vioxx got off to a fast start due to Merck's aggressive marketing practices. The company began distributing the prescription painkiller to pharmacies across the United States just two days after receiving its stamp of approval from the FDA. In the first four months of 2000, Merck spent $67 million on advertising for Vioxx, which was more than any company had ever spent to advertise any other drug.
Merck spent $67 million on advertising for Vioxx, the most any company spent on a drug.
Additionally, at the time of Vioxx's release, the expectations for sales of prescription arthritis drugs looked more than promising, with analysts projecting a surge from $7.2 billion worldwide to $13 billion by 2005. But even with Vioxx becoming Merck's second-biggest drug in 2001, Merck received lower-than-expected sales results that year with projections of only $3 billion versus an earlier forecast of $3.5 billion.
Furthermore, research presented to the FDA in early 2001, not even two years after Vioxx's release, provided information regarding potential safety concerns associated with the use of COX-2 inhibitors, specifically Vioxx. The study showed that patients taking Vioxx had a higher, yet still relatively low, risk of heart attack compared to those taking some of the older pain reliever alternatives. Although the risk was seemingly low, with millions taking the drug, the resulting heart attacks could still be quite significant with four heart attacks thought to occur per 1,000 patients. However, Merck denied claims that Vioxx increased a person's risk of heart attack instead asserting that other pain relievers, such as naproxen, actually decreased a person's risk of heart attack, resulting in misconstrued findings.
From A Vioxx Study
4 heart attacks occur for every 1,000 patients taking Vioxx.
In 2002, Merck agreed to revise its prescribing information for Vioxx to reflect the increased cardiovascular risks associated with the drug compared to older painkiller alternatives, such as naproxen, in response to results from the Vioxx Gastrointestinal Outcomes Research (VIGOR) study. In addition to the new warning, however, the FDA allowed Merck to include results from a study on its label flaunting benefits associated with the use of Vioxx in reducing certain gastrointestinal side effects, such as ulcers, compared to its older pain reliever substitutes.
Still, many became skeptical of the drug's high price (compared to those of its competitors), maintaining that no evidence existed to prove that Vioxx was any more effective at treating pain and inflammation than the more affordable over-the-counter (OTC) medications, such as ibuprofen and other anti-inflammatories. Many also began to believe that the primary selling point of COX-2 inhibitors, fewer side effects, specifically those pertaining to gastrointestinal symptoms, had been oversold. Stronger evidence was available to support Vioxx in this claim based on a one-year study of 8,000 patients. However, that same study also consequently revealed its higher rate of heart attacks and other cardiovascular risks.
Voluntary Market Withdrawal of Vioxx and FDA Action
In August of 2004, just six months after the FDA made the decision to extend Merck's marketing exclusivity of Vioxx following a supplemental new-drug application based on studies involving juvenile rheumatoid arthritis, Dr. Graham released some disturbing news for the future of the reigning drug. A study performed by the FDA investigator found that Vioxx increased the chance of heart attack and death from cardiac arrest significantly more that its number one rival, Celebrex. Furthermore, the study found that dosages of Vioxx in excess of the recommended daily dose of 25 milligrams more than tripled a patient's risk compared to individuals who had not consumed painkillers within the last two months.
A study found that excess dosages of Vioxx tripled a patient's risk of cardiac arrest.
A spokesperson for Merck disagreed with Dr. Graham's findings, citing that the study would carry more weight if it compared two groups of patients actually taking the medications for a set time period. However, the following month, despite Merck's continued denial of increased cardiovascular risks associated with its leading arthritis painkiller, the company made its announcement of a voluntary market withdrawal of the controversial drug on September 30, 2004, with roughly two million people worldwide still using the medication.
FDA Undergoes Congressional Interrogation
Following the voluntary withdrawal of Vioxx, the FDA responded to questions regarding its practices, specifically as to its expedited review process and its timeliness in conducting and stopping clinical trials when adverse information is found that potentially puts the public at risk. The FDA was also under scrutiny for what some described as its seemingly cozy relationship with Merck. It even came under Congressional interrogation at a Senate Finance Committee hearing with witnesses offering testimony describing how danger signals of Vioxx went ignored.
The FDA asserted that Vioxx received a six-month priority review due to the drug's potential for a significant therapeutic advantage over existing drug alternatives, specifically fewer gastrointestinal side effects such as bleeding. Additionally, while the APPROVe trial enrollment for Vioxx began in 2000, the FDA maintains that it was not stopped earlier because the results for the first 18 months of the trial did not show any increased risk of confirmed cardiovascular events on the drug.
However, questions still remain as to the FDA's dealings with Merck and its handling of Vioxx, and whether it used due diligence in protecting the public from the potentially dangerous effects of the drug. An article written by a professor of medicine and epidemiology and public health, among other academics, and published by the National Institutes of Health, calls attention to Merck's early suspicion of cardiovascular risk. The article alleged that even though scientists at Merck had knowledge that the drug might adversely affect the cardiovascular system by increasing thrombus formation, which acts in opposition to the balance of blood flow and clotting, none of the intervention studies submitted along with its new-drug application to the FDA in 1998 were designed to evaluate such risk. The professors claim that despite FDA concern, Merck was permitted to continue to obscure data in an effort to promote the drug's cardiovascular safety.
More Stringent Labeling for Selective and Nonselective NSAIDs
While Vioxx is no longer available for sale or purchase by prescription or otherwise, the FDA acknowledged that it did not request the recall of this drug. However, the FDA did assert that it will carefully review any proposal from Merck for resumption of marketing of Vioxx and would likely discuss the review with the new FDA Drug Safety Oversight Board and an Advisory Committee before making a final decision.
In any case, the demise of Vioxx resulted in more stringent rules imposed by the FDA on all manufacturers of COX-2 inhibitor drugs and OTC NSAIDs. The FDA requested that all manufacturers of OTC NSAIDs revise their labeling to include more specific information about potential gastrointestinal and cardiovascular risks, including information to assist consumers in the safe use of such medications.
Additionally, the FDA requested that all manufacturers of all marketed prescription NSAIDs, including Celebrex, a COX-2 selective NSAID, revise their labeling for their products to include a black box warning and a Medication Guide. The boxed warning is required to highlight the potential for increased cardiovascular risk as well as the serious and potentially life-threatening gastrointestinal bleeding that can be associated with such drugs.
Kristin Compton
Kristin Compton is a medical writer with a background in legal studies. She has experience working in law firms as a paralegal and legal writer. She also has worked in journalism and marketing. She's published numerous articles in a northwest Florida-based newspaper and lifestyle/entertainment magazine, as well as worked as a ghost writer on blog posts published online by a Central Florida law firm in the health law niche. As a patient herself, and an advocate, Kristin is passionate about "being a voice" for others.


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Brand Label: Giambattista Valli
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Black wool and silk ribbed shift dress from Giambattista Valli. Size: 44. Gender: Female. Material: Silk/Virgin Wool.
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text:
Skeletal remains found in attic walls may belong to woman missing since 2015
Mary Cerruti lived alone in her house on Allston Street in the Heights area of Houston and kept to herself. She was seen once at a city meeting where she protested the new apartment complex that was to surround her home on one side in 2012, but little after that. Then one day a neighbor noticed she didn't see her anymore. Time went by and Mary's home was foreclosed on after her mortgage wasn't paid. The payments had stopped in 2014. One media report says a missing person's report was filed in September 2015, another said it was never filed because the police required a relative to report her missing.
What happened to Mary was asked but no one seemed to really delved into what happened to her except for one neighbor that hired a private investigator. What they found was a lot of dead cats in her home, but no Mary, reports the Independent Journal Review. Her ex husband that lives in Brooklyn had no idea where she went. Then in 2017, the new owners of the home noticed a loose board while storing things in the attic. They pried it up and looked inside to see the skeletal remains, reports the Daily Mail. Along with the bones were found a pair of red glasses, like Mary would wear and a patch of material.
It's only speculation how the remains got there. At this point no one knows for sure if it is Mary's remains until DNA is done, but it is likely it is her's. How she ended up where she did is anyone's guess. Some thought she may have been looking for one of her cats and accidentally fell and over time her remains ended where they did. There are also theories that she was murdered and her body hidden there. We'll have to wait for the medical examiner to sort it all out.


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From Traditional to Contemporary; from Modern to Transitional, our team are capable to design and create any kitchen style you dream of. We are always expanding our knowledge to keep up with the newest and greatest trends. Our goal is to provide you with a functional, and aesthetically appealing kitchen environment that everyone will compliment.


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Listen to free music by Fyah T
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Page Creation
I have been reading different forums and I cannot seem to get a clear solution to the problem of creating a static stand-alone page with the header,footer and sidebar of my site theme. The purpose of this to be able to run MySQL queries and embedd all that into this static page. It is my understanding that the WRITE tool in the admin portal is to create pages which have the content stored and showed when that particular page is displayed. I just want to create physical .php pages with the theme and store them in a members folder.
I have read through the template section as well but can't seem to find something that fits the problem.
I am new to wordpress, so please excuse me if it all sounds trivial. Thanks again for any help!
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text: MVHS staff hosts Volunteer Tea 0 By Sanskriti Sharma on April 28, 2015 Featured, News On Wednesday, April 22, the MVLA administrators held a Volunteer Tea to honor all of the amazing volunteers that have helped throughout the year. See below for pictures of the event! p1010002 ◄ Back Next ► Picture 1 of 48 Sanskriti Sharma Share. Twitter Facebook Google+ Pinterest LinkedIn Tumblr Email


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PORTLAND—in the late 1800s, Portland's Back Cove was conceived as a "pleasure basin" by the landscape architect Frederick Law Olmsted. Today, this watery pearl in Olmsted's "Necklace of Green" is tarnished by trash. Friends of Casco Bay organized a clean up of Back Cove with environmental engineers, public relations professionals, and other staff members of CONTECH Stormwater Solutions, a company that produces products to reduce stormwater runoff. They saw firsthand what ends up on our coastal shoreline from stormwater runoff and discharges from combined sewer overflows. In less than two hours, they collected 15 bags of trash, including a hubcap, a Halloween mask, a hardcover copy of The DaVinci Code, and a dozen syringes from the shoreline below the parking lot by Back Cove. Portland Public Works Department had provided Peter Milholland, volunteer coordinator for the environmental group, Friends of Casco Bay, with tools to pick up and dispose of medical wastes. When the volunteers located a syringe, they marked the site with a flag and yellow tape; only one member of the cleanup crew was allowed to pick up the syringes. Shortly after the Patriots Day storm, a clean-up by Friends of Casco Bay, the Back Cove Neighborhood Association, and Portland Trails found a similar number of syringes. City engineer Brad Roland suspects that the syringes were probably flushed down toilets and were washed into Back Cove through nearby combined sewer overflows during a heavy rain. He said he didn't think that the syringes came from anyone with persistent medical conditions, such as diabetes, as they are normally well educated in how to properly dispose of medical wastes. The Public Works Department cautions anyone who finds a syringe not to pick it up themselves.
Since 1989, Friends of Casco Bay has been working to improve and protect the environmental health of Casco Bay through advocacy, education, collaborative partnerships, water quality monitoring, and other scientific research. FMI, visit www.cascobay.org.


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by Alisha Jackson
When Slash and Duff McKagan showed up to Axl Rose's gig with AC/DC at the Olympic Stadium in London, it melted our hearts. Learning that their attendance was a surprise for their bandmate adds even more feels to this feel-good story.
Duff recently sat down with Jonesey Jukebox where he talked about the show. "Me and Slash and our ladies went over to London just to surprise Axl and to see the AC/DC thing at the new Olympic stadium. And it was amazing," he said.
"We went for a Saturday, basically. We had to get back… There was a graduation and there were things going on, so I had to take the 9:00 a.m. flight out Sunday morning. But we got to see him do that thing with AC/DC, and it was magical." Duff went into detail about the show, mentioning how Axl got up out of his chair during the show. "He was out of his chair; he was up and cruising around," he said. "He was kicking the boot; he was doing the kicks. And it was really great to see… I'd never seen him, I guess, play… see him sing. And I think it energized the band — they were pretty energized — and the crowd was into it. It was cool. I'm super stoked for him."
According to Duff, Axl's injury may be to blame for all the mushiness surrounding Guns N' Roses as of late. "It was just strange, the whole thing," Duff recalled about the night Axl broke his foot. "[It was] our first show. [It happened during] the second song. He didn't complain once. That's the thing. We finished the show. He said, 'I think I broke my foot.' And sure enough, six pins later… And he didn't complain one time through that whole chair thing. So… I think everything happens for a reason. I think it drew us around… kind of drew us in tighter. And singing those kind of songs sitting down is a tough, tough deal. So, I think, yeah, he persevered."
To watch part of Duff's interview, see below. To listen to the full interview, click here.


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Between 22 Feb and 2 March I will be in Marbella on Spain's southern coast and hope to do activations in EA7 and possibly EA4, EA5 (maybe an overnight trip?) and/or CT (again, maybe an overnight trip?). I would be pleased to meet with any local activators (joint activations?) or chasers while I am there.If you are interested, please get in touch with me at aa1mi [[[at]]] arrl [[[dot]]] net.73, hpe CU Paul HB9DST / AA1MI
Hi Paul,EA4 is a bit far from Marbella, even the most southern provinces.....In the event that of you get to Madrid, please drop me a line.Best 73Mo, EA4MZ
Hi Paul
The closest CT SOTA summit is 400km away from Marbella.If you decide to visit Lisbon, email me. I would be pleased to meet you here.
73Pedro, CT1DBS


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Eco-Huts are built to support Kahendero Humanist Primary School
Posted: Tue, February 28, 2017 | By: Kahendero
by Bwambale Robert Musubaho
A local artisan and builder has been contracted to work on construction of Hut #1 at the Kahendero property.
The huts will generate an income that will strengthen and empower the Bizoha School in Kahendero to become a self sustaining good school.
Its to be constructed using bamboo as poles, rids, mud, stones, rafters, spear grass and some timber peels.
The hut is part of several huts intended to be constructed on our Kahendero property as a way to raise more finances that can boost our school develop to another level. Our intention is to create a self sufficient, reliant school that can be in better position to meet all its needs so that all our staffs remain happy, we too also wants our parents to realize good returns from the support they extend to educating their children with us.
The Kahendero property boarders Queen Elizabeth National park and each night wildlife roams around our school hence this puts it at a better site to favor tourists view the animals at dusk till dawn.
To support us in our campaign of eco huts, visit this web link and get involved. Thank you. http://africahumanists.org/kahendero-humanist-primary-scho…/
With Science, we can progress.


text: On Sun, Oct 24, 1999 at 08:48:21PM -0600, Jason Gunthorpe wrote: > > Like Gregory said, experimental serves a purpose that is not covered by > your 4 pools - software in there literally does not work.. Yes, but pool can have multiple versions of a same package. > > dependencies resolvable withing "working". This may be checked > > automatically, the necessary code is already in apt-get. If this > > Actually it isn't.. APT has algorithms to check a subset of the possible > conditions, but does not check certain conditions involving conflicts, > which prove to be extremely difficult. [Note this only applies to the > distribution as a whole, ie the apt-cache unmet command] Hmm. I actually meant to use apt's install-time dependency check. It's smart enought to know when something is "installable". > > 3: To be nicer on mirrors, Working should at all times be simply > > a forest of symlinks into Pool, because mirrors can't handle the > > movement of a file (they just delete it from the old location > > and download it again for the new one). > > Actually our mirror network is being upgraded to handle hard links which > obviosly solve the migration problem. You mean, use something similar to inodes to know the real "identity" of a file? That would be great. > > 4: dpkg-scanpackages, or whatever is used to generate Packages > > files for apt, must be fixed so that when multiple versions are > > found, the newest one is used (currently it uses the first one > > found, which will give filesystem-dependent results). > > dpkg-scanpackages should just include all available versions, the APT > GUI's people are writing can make use of that. [dselect can get upset if > not used through apt, but it could be patched] Yes, but this means we would require the apt people to fix their front-ends by the time of the change. I didn't want to add this extra requirement. If it's ready by then, so much better. > > delete the "project/experimental" area. Of course the promotion > > automating software must be working and tested by then. > > In 2 months? Not likely.. Why not? An email responding bot (borrow from BTS), an archive-handling script (borrow from dinstall) and a dependency-checker (borrow from apt)? Looks like work for a week. 2 months give time enought for testing and debugging. []s, |alo +---- -- I am Lalo of deB-org. You will be freed. Resistance is futile. http://www.webcom.com/lalo mailto:email@example.com pgp key in the web page Debian GNU/Linux --- http://www.debian.org Brazil of Darkness - http://www.webcom.com/lalo/BroDar


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Over the summer some of our parent members were featured in a documentary about paid family leave. You can watch it here. The piece was filmed in Portland, produced by Al Jazeera English and aired on their networks throughout Europe this past week. We think it makes a good case for the need for paid family leave that supports America's working families, and hope this issue will be getting some media coverage closer to home very soon.
The women who were interviewed did a fantastic job of sharing their stories, don't you think? If you'd like to share yours, please do so here. They are very important in helping folks in Salem understand why this is so very important to Oregon families.


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Saturday, 28 November 2009
Christmas Anya
This is for:-
1. Anyone For Anya? - "Make A Fake"
2. Sketch and Stash - challenge 24 - sketch
At Anyone For Anya the challenge is to "make a fake", so on my Anya I used flock as fake fur.
Sketch and Stash has a fab sketch this week and you have to name your new, never used or neglected stash. Mine is using Flock for the very first time, I think I need to use it a couple of times to get the hang of it.
To be honest not keen on the feel of Flock after using it for the very first time on this card, it's like cotton wool and I don't like the feel of that either. it makes me cringe, but i do like the result with the flock.
Well I want to apologise if I'm not getting around to everyone's blogs for a visit, as my two boys are not very well at the moment. My eldest has tonsilitis and a cough which is making is chest sore. And my youngest has croup again with rather a nasty chesty cough, sore throat and runny nose during the day and blocked at night.
Last night was bad, one or the other of the boys had me up at least every hour, they couldn't sleep, then there was steaming in the bathroom for the croup, then one of them needed a drink etc... etc. But what I can't understand is how can they be up all night then awake all day too.
But bless them they are suffering and I rang the emergency doctors but they are not classed as an emergency, so I was told just to keep them on simple linctus and paracetamol.
So I'm shattered but will try and get round to as many blogs as I can.
Happy crafting
Tracy x
15 comments:
I also like the result of the flock, never heard of it. Pretty snowflakes also.ReplyDelete
Love from AFA!
love this hun its gojus love those colurs too love cheryl xxxxReplyDelete
This is soooo cute, I love how your flocking turned out it looks darling on Anya!!! You got all the right spots girl!!! Perfect touch with the snowflakes...Fabulous card Tracy!ReplyDelete
Hi Tracy, beautiful card hun. Im like that with flocking lol cant say that after a few sherrys lol.ReplyDelete
Sorry to hear the boys not well, its not nice for any of you. I hope you all get some good rest and I hope they get better real soon hunny.
Luv Lisa.xx
Hi Tracy, your Miss Anya is just gorgeous!, love the soft blues on this.ReplyDelete
I hope your boys feel better soon... not nice when the kids are poorly.
Sheila xx
Thanks for the lovely comment Tracy its nice to meet another Tracy without an 'e' in their name love the really cute anya.ReplyDelete
I used the white flower soft on my card for first time and it hasn't exactly won me over so I know what you mean.
Hope your boys get better soon
hugs Tracy x
Hi Tracy,ReplyDelete
I love this gorgeous card and the image is beautiful. The flower soft is so effective.
I hope your boys feel better soon and that you get some rest. You must look after yourself too. Will be thinking about you.
Fiona x
Tracy you card is beautiful!Hope your boys feel better real soon!ReplyDelete
Sounds like you need a rest,Tracy.....one ill child is enough!!! The card is gorgeous though....I really like the effect of fun flock....and one pot lasts forever.ReplyDelete
Gorgeous card :-) I love this image and the papers and sparkle all look fabulous ! :-)ReplyDelete
Thanks for joining the Sketch and Stash Challenge:-)
Lols x x x
A beautiful card,love the blues.Hope you are all feeling better soon.xReplyDelete
This is a stunning card tracy great image and fabby colouringReplyDelete
hope you are keeping warm its freezing down here
Hugs Susie xx
Wow Gorgeous card Tracy!! Very Cute!ReplyDelete
Gorgeous card Tracy, I just love those snowflakes!ReplyDelete
Thanks for joining in with Sketch & Stash.
beautiful card Tracy I hope the boys are feeling better soon and you get some sleep thanks for joining us at sketch n stash hugs Jill xxReplyDelete