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Minster FM News
Coronation Street Killer To Star In York Mystery Plays
10:16am 29th May 2012
(Updated 4:47pm 29th May 2012)
The actor who played one of Coronation Street's most infamous villains will play the Devil in York Mystery Plays 2012.
Graeme Hawley, 37, was nominated for Villain of the Year in the 2009 and 2011 British Soap Awards for his role as John Stape.
Graeme, who has also appeared in Shameless, A Touch of Frost and Emmerdale, said he was thrilled to be taking on the role in the biggest outdoor theatre production in the UK this year. Graeme will star opposite Ferdinand Kinglsey, 24, who was announced last week as playing both God and Jesus in the plays.
Both will start rehearsing with the rest of the 500 strong cast next month.
Graeme says:
"I am thrilled to be taking part in York Mystery Plays this summer in what I'm certain will be a truly spectacular production. I am used to playing bad guys and they don't get much bigger than the devil!
"The plays are a really important part of York's heritage and it is an honour for me to be chosen to take part in something which has such an important place within the city and beyond. It has been an ambition of mine to work with York Theatre Royal, for many years, so I am over the moon to finally get that opportunity.
"I can't imagine a better place to spend the summer working on this amazing production! I am looking forward to meeting and rehearsing with the rest of the 500 strong cast and then performing in such an outdoor setting. I am sure it will be a fantastic experience for me and hopefully for the thousands of people who come to watch."


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YOU CAN EDIT THIS PAGE! Just click any blue "Edit" link and start writing!
User talk:188.8.131.52
From Wikitravel
Please be aware that when quoting milage or temperature, we prefer the local units of measurement with the non-local format in parenthesis. So for Las Vegas, we prefer miles and Fahrenheit with metric in parenthesis. Thanks for adding the missing items -- Colin 13:48, 12 October 2008 (EDT)
This is the discussion page for an anonymous user who has not created an account yet, or who does not use it. We therefore have to use the numerical IP address to identify him/her. Such an IP address can be shared by several users. If you are an anonymous user and feel that irrelevant comments have been directed at you, please create an account or log in to avoid future confusion with other anonymous users.

subset: commoncrawl


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Popular presenter Michael Lyster makes welcome return to The Sunday Game
It was the sight all GAA fans were hoping to see - The Sunday Game presenter Michael Lyster made a welcome return to his natural habitat.
After time out from his recnt illness, the Galway native was joined in studio today by Colm O'Rourke, Ciaran Whelan and Pat Spillane as part of the RTE coverage for the Ulster and Connacht football finals.
Last week the affable presenter was in Thurles to catch up with his work mates, with Joe Brolly tweeting a picture of Lyster in conversation with Spillane and O'Rourke in the studio ahead of the Munster hurling final.
Read more: Pic: A smiling Michael Lyster returns to the RTE studio
Lyster was rushed to hospital in June after suffering a heart attack following a day out playing golf in Portumna.
Last month, Lyster revealed the seriousness of the heart scare in an exclusive interview with Irish Independent.
"Everyone was in bed, so Vincent (Hogan, Irish Independent journalist) called up the stairs to my wife Anne, and she came down and started CPR, while he phoned for an ambulance," Michael says.
"I don't know if I would have stayed as calm as Anne did, she's very good under pressure. The clock was ticking, I suppose, so she was told to keep the CPR going until the ambulance got there. It was a very bad situation and I was actually gone, so when the paramedics arrived, they had to keep me going until I got to the hospital.
Read more: Video: Healthy looking Michael Lyster thanks fans for support following recent heart attack
"There's no point worrying for the rest of your life," he says matter-of-factly. "I had a shaky call, obviously, but the recent tragedies in Berkeley and Tunisia put it all into perspective, and show how unlucky you can be to be in the wrong place at the wrong time. I was never a worrier anyway, as I spent 20 years involved in rally driving, and let's face it, there's no point worrying about your health in that particular sport."
Ready to go here on the #SundayGame, Michael Lyster back in the anchor's chair today! 1.30pm @RTE2 pic.twitter.com/ncI4dnrCnj— The Sunday Game (@TheSundayGame) July 19, 2015
And there's Michael Lyster back on the sunday game, which is good to see in itself, but also that he's looking very well.— Matt Cooper (@cooper_m) July 19, 2015
Great to see Michael Lyster back on the Sunday Game! RTE getting him back into it nice and easy by leaving out Brolly #SundayGame— Tom Flynn (@tom_flynn14) July 19, 2015
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- Pic: A smiling Michael Lyster returns to the RTE studio
- Video: Healthy looking Michael Lyster thanks fans for support following recent heart attack
- Michael Lyster is... Back in the game


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This popular book addresses the full practice of family nursing—identifying the family as a whole—and teaches a holistic, philosophical approach. The reader is guided through generalized concepts and theoretical foundations, reality-based applications, case studies, thorough and updated discussions, assessment, and nursing diagnoses. Well-organized and complete, this edition includes foundations in family theory and family nursing—essential in preparing a comprehensive family nursing assessment and planning appropriate interventions.
A four-part organization covers introductory concepts, theoretical foundations of family nursing, family nursing practice, and cultural diversity among families.
For pediatric nurses, nurse practitioners, family counselors, clinical nurse specialists, and anyone planning for a career in family or community cursing.
This book provides a foundational knowledge base for the practice of basic family nursing. As increased emphasis is placed on the family unit as an integral component in healthcare, readers will find this a valuable resource in addressing the complex issues in family nursing. The purpose is to provide in-depth information on the gamut of the emerging roles and goals of the family nurse. The author addresses the basic theoretical approaches used in family nursing practice and provides family nursing interventions that are basic and straightforward. The book provides students with the information needed to deliver a family-centered approach to care. There is special emphasis given to primary prevention, particularly health promotion. This book is intended for undergraduate and graduate students who hope to practice basic family nursing. It is not designed for those who are practicing advanced family therapy or family systems nursing. Five major issues related to family nursing are addressed in this book: the importance of the family in healthcare, with succinct definitions of the varied family unit; an explanation of the basic theoretical approaches used in family nursing practice; an introduction to family assessment tools and models for family interventions; general family nursing interventions; and information on cultural issues pertinent to family nursing care. Learning objectives are provided for each topic. Self learning modules and case studies are incorporated in many of the chapters throughout the book. Each chapter provides study questions for the student to address. This easy to use and straightforward approach to family nursing will make this a valuable resource for thebasic family nursing student. The material is concise and well organized. It provides much needed clarification on the concept of family nursing.


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So I've never declared a "word of the year" before. I've also never been forty-six and felt so blah about so many things in my life. Don't get me wrong – there are an abundance of things in my corner of the world that are fantastic. MORE THAN FANTASTIC. However, I feel like there are more things that I opened my eyes to – in my little world and the greater world at large – that I need to make room for. And there is a not that I need to let go of. Which is why my word of the year is . . .
Shift seems to be the sum total of every goal and intention I have for 2017. To define, shift means "a slight change in position, direction or tendency"
1. I'd like to shift my health back to a place of caring. For me, that means being more intentional with the foods I eat (and bring in to my home), and finding a way to incorporate some sort of exercise that I find enjoyment from in to my life.
2. I'd like to shift my perception of those around me and what I feel their judgment of me will be if I am my authentic self. This is a hard one. As I mentioned in my birthday post, I've really wanted another tattoo and to color my hair something fun for a while now, but was too afraid to do it because of what I thought others would think of me. I have to shift that mindset in my own head, and realize that it IS my life. I do get to choose who I want to be. And if I'd like a tattoo on my wrist to remember my dad then I get to do that. The end.
3. I'd like to make a shift in the way we look at our home and possessions. G and I have been reading and hearing more and more about minimalism, living in spaces that are the right size for you, being intentional with the things that you bring in to your home, and to stop collecting "stuff" just to have it. I own right here and now that I have hoarder-like tendencies. I was raised with the "just in case we might ever need it" mentality and there are a LOT of things in my home that fall in to that category. During the downsize almost three years ago, we purged about a third of things that we didn't need. But there is still a lot here – and we have added to it – that we just don't use or need. While I'd like to not donate EVERYTHING, it would be nice to make a little money from the things with value. Tag sales are not allowed in our area. And I'm not sure about the hassle of Craig's List or the like. But I know it is a shift that I want to make happen.
4. I'd like to make a shift in my self-care. Currently, it involves a lot of sitting on the couch, watching bad reality television (well, some of it is good) and eating. I miss reading books. I miss sewing. I miss being creative. I miss my friends. I need to find time to do the things that feed my soul as opposed to turn my brain to mush. Last Thursday, I had three friends over that I had not seen in a really long time. The four of us had not been together in two and a half years. And we all live in the Chicagoland area. I need these people in my life, and I need to do a better job on my end making time.
5. I need to shift the way I look at parenting. I will say that most of the time, I'm a decent mom. But I'm getting lazy the older they get because I am tired so much (see number 1 and 4). I think if I take steps to shift the way I feel, physically as a person, then my parenting value will only increase. I love my daughters so much, and I spend a lot of time with them. But it isn't quality time. There are life lessons that I'm dropping the ball on teaching them. (I just figured out that my 11 year-old didn't know how to work a vacuum!) There are relationship building things that I need to do more to lay the foundation for, because mother-daughter relationships generally suck and I may only have a few more years with them before they start turning on me. I need to step it up. I can do more. Do better.
6. I need to make a shift with our home finances. I implemented Dave Ramsey-esque money management systems this year and it worked great – when I worked it. Unfortunately, when I am stressed or unhappy, my go to's are eating and shopping. I'd like to be farther along in my savings and debt pay-down plans that I am. Ideally, the only debt I would like to have are the car payment and our mortgage, both of which I pay more principal every month to get ahead. The one pesky credit card I have is a weakness, and I'd like to get rid of it for good. If I can implement #3, then this will help tremendously.
7. I want to continue to let the shift within me blossom. This last year taught me a lot. Opened my eyes to things in this world that I didn't realize were happening, didn't understand the causes, hadn't thought to dig in to because it didn't impact my day-to-day life. I can't be the person that lives blindly in the world anymore. I've learned too much this year. The biggest thing? I still don't know a damn thing about what people who don't look like me go through every day. I'm terrified at the thought of what the next four years will bring. I don't have to scream what I believe from the rooftops to get those around me to listen. I do, however, have an obligation to speak up when I see wrong. To call out those things that are unjust, biased, racist, bigoted, homophobic and just plain factually and morally wrong. My voice means something. It's okay for me to have conversations about race and how it makes me feel; a white woman who is terrified of saying the wrong thing and doing the wrong thing but wanting to help share my outrage and anger and frustration over what is happening and be a part of the solution. I want to be part of the solution, more than signing a petition on Facebook and making a donation to a GoFundMe page. My words, my actions, the places I volunteer, and the ways I use my social media influence will all reflect the continued shift inside of me.
So there you have it. Go out and find your work for 2017 and let it be the force that guides you through the year. And I leave you with these beautiful words from one of my favorite authors, Cheryl Strayed:


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During the installation of LinuxMint 8 I removed all partitions and Installed it on all the drivespace available. However I had forgotten that my external hard drive was still in the back and thats where most of LinuxMint now is.
Now It wont boot up without the drive attached, and I don't want to try removing partitions to get my external drive back without knowing exactly what I'm doing.
If anyone can give me instructions as to how to recover my extremely precious data and the old partitions so I can reinstall just on the computer's hard disk I would be extremely grateful as I was really enjoying my 'successful' installation until I realised I had no music...:sad:
82GB Filesystem {the computer's drive
type: HPFS/NTFS (0x07)
250GB Hard Disk {my portable drive
>247GB Filesystem
>3.1GB Extended
>3.1GB Swap Space
Thats how its organised at the mo


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For many businesses information communication technology (ICT) infrastructure is now one of the largest contributors to their carbon footprint. Driven by investor and consumer environmental concerns, organisations are implementing environmental policies across their operations and making green considerations an important factor in ICT purchasing decisions.
Up until very recently the 'green' spotlight has generally focussed most on heavy industries including mining, petrochemicals and utilities. These industries have made attempts to develop robust environmental management policies and have been concerned to establish their green credentials. While not always seen as shining beacons for the environment they have made significant efforts to address environmental concerns raised by their business practices.
That spotlight has altered and it is the IT industry which is under increased scrutiny. Now more than ever before the green credentials of ICT providers are under the microscope and are seen as critical to their standing in the marketplace. As climate change, carbon emissions and energy consumption have become issues of mainstream concern, customers are now assessing providers on the environmental impact of their technology offerings rather than focussing only on more traditional criteria such as performance and value for money.
Impact of ICT industry on the environment
Businesses in Australia generate more carbon dioxide emissions from their use of ICT than the entire civil aviation sector. In the United States, servers alone account for 1.5% of all energy consumption (a figure expected to double in the next few years). Organisations are beginning to factor carbon emission costs into their pricing structures, as they recognise that use of environmentally friendly ICT is a market necessity.
Rising energy costs too provide a further financial incentive to pursue green ICT solutions. Electricity used for operations and cooling accounts for 60% of the day-to-day running costs of a typical data centre and due to decreasing server prices. It is estimated that it will soon cost more to power and cool servers over their lifespan than to purchase them.
Businesses and industry response
So what response have we seen from industry? Both consumer businesses and the ICT industry have reacted to global environmental concerns, and have introduced strategies to reduce their carbon footprints and power bills.
The Australia and New Zealand Banking Group estimates that 40-50% of its power consumption is directly related to its ICT infrastructure. By simply banning the use of screensavers in the office, ANZ was able to reduce its energy consumption by 4% and save A$500,000 in electricity costs.
Macquarie Telecom recently awarded a major ICT contract to Sun Microsystems, passing over its incumbent supplier on the basis that Sun had better environmental credentials and would therefore help Macquarie to reduce its carbon emissions and power usage.
Many ICT providers have become involved in consortiums such as 'Green Grid' and the 'Climate Savers Computer Initiative' which aim to develop energy efficiency standards and metrics for the industry. At an operational level, a number of ICT vendors including Dell, HP, IBM and Sun Microsystems have all developed more energy efficient ICT products and services, and are branding their organisations as environmentally friendly. These vendors are focussing on enhancements to their product offerings in relation to cooling techniques, energy efficiency, recycling and green manufacturing.
New eco friendly technologies are diverse, and include:
- server virtualisation and thin client technologies
- power management applications
- more efficient server configurations and hardware
- improved cooling systems for servers (especially in data centres)
- the replacement of traditional telephone systems with IP phones.
The Australian Federal Government, one of Australia's largest ICT consumers, has indicated that it may introduce government grants of up to A$1 million for secondary schools to invest in thin client technology. Thin clients were singled out as the preferred technology for their reduced cost and improved energy consumption when compared to the usual desktop environment. As the government rolls out its National Secondary School Computer Fund, providing computers to every student in years 9-12, ICT vendors with strong green technologies appear likely to be well placed to profit from this A$1 billion initiative.
Environmentally friendly ICT purchasing and procurement
The shift in the ICT market towards environmentally friendly products and services is already having a significant impact on customer ICT procurement behaviour. Vendors who can demonstrate eco-friendly ICT solutions that respond to customer environmental concerns will win the business.
Middletons has extensive experience advising both suppliers and customers on ICT procurement transactions. We are seeing more and more tenders requiring vendors to demonstrate their 'green' credentials in both their technology offerings and approach to the market. The requirement to demonstrate compliance with robust corporate social responsibility policies and dedicated environment policies is becoming commonplace in larger transactions. Customers too need to be aware of which suppliers offer green ICT products and services.
There is no avoiding the green spotlight. As eco-friendly contracting becomes the norm, customers will vote with their feet. Are you confident that you have the expertise to maximise your organisation's ability to take advantage of an environmentally aware ICT market? Make sure you are not left behind!
The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances.


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I use Google Images to search for images. Images used are also approved via the actual person or the publicist of the person that is featured on a blog. When clicked onto the image or the caption, it will link to the image source. When possible, In most cases, I will caption the image with the name of the person or business who owns the image, if they have a site. If you own any image(s) I have on ListenSpeakRadio Blog and would like it removed or to have the caption edited, please send me an email at email@example.com and I will remove or change the specified image(s) ASAP.
All the material that is quoted will be link to the source(s) from which it was taken and/or have the name of the source. If the source is unknown, it will be credited to "anonymous". If any of my quoted material is incorrectly credited, or if you know the name of an anonymous source, please send me an email at firstname.lastname@example.com with the quote or link in question, the correct source name/link, and reason for the correction.
If you have any questions or concerns about any posted material, please feel free to contact me via email, comment, Facebook message, or Twitter. All contact information can be found on the Contact page. Thank you.


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105 Indoor Herb Seed Garden Planting Kit Gift Sets - Oregano and more
These DIY Garden in a Box kits are a fun and easy gift that keeps on giving. Each one contains everything needed to start growing an herb garden right on your kitchen counter or office desk. This earth-friendly gift includes 100% biodegradable materials - our unique recycled plantable paper that we make ourselves, plus our wonderful plant-based biodegradable pots.
Easy and affordable gifts with meaning - they are wonderful for office mates, housewarming gifts for friends, and for kids. If you know budding chefs or beginner gardeners, these sweet gift boxes supply everything they need to get going! Just add water and warmth and a bit of sunshine.
Dig life * Plant seeds!
Yes! Complete planting instructions are included.
Create your own custom arrangement from among 7 seed types: Oregano, basil, dill, parsley, and lavender for herbs plus a flower seed mix and also kale for healthy eating. Kale is a perfect green to try first as a vegetable to grow because it sprouts so easily and can be planted even in cold weather.
The package is a set for self-assembly with everything included so you can gift them in their own 4 inch kraft gift box with a natural raffia ribbon and tag that identifies the seed type. Self-assembly is assumed.
Each planting kit comes with the following:
- 1 plantable paper seed leaf (your choice seed type)
- 1 eco-friendly biodegradable pot, 2 inch
- unique plant-based desktop greenhouse biodome
- expandable soil pellet for growing
- planting instructions
- kraft paper gift box, 4 inches
- natural raffia ribbon
- tag that identifies the seed type
These clear cups are made entirely from plants: corn. Each one is 100% compostable and biodegradable. Growing with these cups helps seeds to sprout because they seal in moisture. The top features a vent hole with removable cover so you can let out excess moisture if it becomes too humid inside the biodome. The covers are labeled with the seed type. When you order the greenhouse biodome, you also receive a 4 inch gift box, for a nice gift. After the seeds have sprouted, you can re-use the biodome for more seed sprouting with another pot and then compost it when done.
......... ABOUT OUR BIODEGRADABLE POTS and PAPER .........
These fiber pots are a more environmentally sustainable choice than peat-based paper and plastic pots (peat takes thousands of years to form before it can even be harvested). These plant fiber pots also create a wonderful growing medium that can help seeds germinate and plants to grow. They are made from the fiber between the husk and outer shell of a coconut. Seedlings flourish in them and, because the pots can be planted right in the ground, root system and all, stress to delicate seedlings from being transplanted is reduced.
Growing with a biodegradable pot makes everything easy — just plant the entire pot right in the ground. No plastic waste left over.
The fiber inhibits mold growth and helps plants grow stronger root systems. The roots grow right through the sides of the pots instead of balling up inside a plastic pot. When using coir, plants require less fertilizer and are more resilient to disease. The fiber improves moisture flow and actually helps seeds sprout. All pots are made from 100% peat-free renewable fiber.
The seed paper leaves are made from recycled paper and embedded with the seeds to start the garden. Each leaf contains a specific seed type. To start the leaf growing, simply wet it and press it into damp soil.
Made with eco-friendly packaging that is either recycled or meant to be recycled. It is easily biodegradable and compostable.
All paper is made-to-order to promote freshness. Through winter, the wait time after most orders are placed is about 4-7 business days before an order ships. During spring and summer, orders can take longer, typically 1-3 weeks. If you need your order within a specific time frame, please contact us to see if your order can arrive in time. You are always welcome to upgrade to faster shipping options at checkout.
If you have questions about this product, shipping, or would like to speak with us directly, please email us.


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GraphicRiver Creative Food Menu 15 8606720
Print Template \ Food Menus
Restaurant \ Sample \ Quality \ Creative \ Images \ Properly \ Structure \ Editable
Print Template - Creative Food Menu 15 8606720 by VortexDesign @ GraphicRiver
Print Template \ Food Menus
A creative die-cut food menu, with flat-styled contents. Suitable for any kind of restaurant/diner.
- InDD file format available.
- See Screenshots for photos of a real-life, printed sample of the menu. This sample is a high-quality digital print on a 150g High-Quality Matte paper.
- Neatly organized layer structure, properly named and color coded. Fully editable.
- Print ready: Bleed & trim / CMYK / 300dpi.
- Print size: A3 – ISO (420×297 mm).
- Images used in the preview are not included.
- Free fonts used: Bebas Neue & PT Serif
Last Update: ; Layered: Yes; Graphics Files Included: InDesign INDD; Minimum Adobe CS Version: CS6; Print Dimensions: 16.5x11.7.
Creative Food Menu 19; Elegant Food Menu 18; Light Corporate Stationary Pack 09; Elegant Food Menu 17; Creative Business Card Bundle 01; Creative Tri-Fold Food Menu 16; Minimalistic Informative Corporate Flyer 03.
Keywords: a3, blue, creative, cut, cuts, diagonal, die, die-cut, diner, flat, flat-style, fold, folded, food, green, images, interesting, menu, modern, print ready, restaurant, shapes, simple, simplistic.


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Former Skid Row frontman Sebastian Bach is being praised after coming to the aid of his best homie Axl Rose at a Guns N' Roses gig on Sunday night.
Sebastian Bach apparently stopped a knife-wielding man from attacking Axl Rose at a recent GNR show at Gramercy Park Hotel in New York. A source told the New York Post, "the man walked in while Guns N' Roses was onstage and pulled out a knife and flicked the blade out." "Sebastian, who was standing on a banquette said: 'Nobody is getting anywhere near my man Axl Rose with a knife,' and went after him. Security then immediately threw him out." The source also stated that the "the man appeared to be drunk" and "was dealt with so quickly that none of the other guests or the band were aware of it."
Kinda wish Sebastian woulda passed on going to the show…
Photo: Marty Temme/Getty Images
© 2017 Spike Cable Networks. All Rights Reserved.


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This None home is located at 0 Hodges Bridge Rd in Doyle. 1731754 was built in 0 and has 0 bedrooms0 Hodges Bridge Rd, Doyle - MLS 1731754 Close
Land for sale in Doyle, TN at 0 Hodges Bridge Rd. This river land is priced at $4,743/acre.
Waterfront Acreage on the Calfkiller River! Just up from Hodges Bridge and the Caney Fork River. Fishing, boating, kayaking, canoeing right off your own river bank. Also available Private wooded lot across the street
Listing information last updated on November 23rd, 2017 at 3:54pm CST.
Have any comments or questions about 0 Hodges Bridge Rd, Doyle, TN? Ask your question and/or share your thoughts about this property.


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In 1829 at the 'grand' age of 37, Gioachino Rossini, (1792-1868) retired from the operatic world, writing only a handful of works over the next three decades. In his latter years, when the ageing composer retreated to his sumptuous villa in the Parisian suburb of Passy, he devoted his time to cooking, entertaining and, most importantly, composing a wonderful array of music, including works for the pianoforte - his 'péchés de vieillesse' ('sins of old age'). In this semifictional account of Rossini's 'twilight' years, the Italian master reflects on the musical achievements of some notable Italian composers. The audience is transported to Rossini's villa, through his musical reminiscences, intermingled with music by Frescobaldi, Martini, Cimarosa, Clementi, and of course Rossini himself. Ambrose Page (piano) Patricia Hope (narrator)
If you're already a registered user of this site, please login using the form on the left-hand side of this page.
Email address (See our privacy statement):
Clifton Montpelier Powis Community Alliance > http://www.cmpcaonline.org.uk/


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✔ FREE Alaska DMV Motorcycle Practice Test 2 2017 | AK
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After you have studied the official State of Alaska Motorcycle Operator Guide, use this free practice test to test your new knowledge. All 50 questions included on the AK motorcycle permit practice test below follow the same format as those that appear on the state's official permit exam. This Alaska motorcycle permit practice test is designed to give you an accurate measure of the probability of your passing the real exam while reinforcing your knowledge of the exam content. Each expertly written question has an optional hint if you need extra help and an explanation in case you make the wrong selection. All in all, this Alaska motorcycle permit practice test is the best study tool if you plan to become an official rider in the Last Frontier.
We're preparing your test...
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40 correct answers to pass (10 mistakes allowed)
Passing score required at the AK DMV: 80%Challenge Bank
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Alaska DMV Test Fact Sheet
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AK Motorcycle Handbook
View the most recent (2017) official AK DMV Motorcycle Handbook.Explore


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Welcome to the ESA Career Center, a targeted resource that connects companies in the Energy Storage industry with highly qualified professionals looking to grow their careers.
At the ESA, we are helping to build a transformative industry to change the way electricity is generated, delivered, and consumed – and this platform allows you to reach a highly targeted audience of industry professionals with the experience and skills your company needs.
Job Seekers:
For job seekers, the ESA Career Center is your portal to the multitude of jobs available in this rapidly growing industry.


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Taku-Hero & Funk Machine – Fun Lovin (Michael Feiner Remix)
Listen here ➡ https://revr.ec/FUN-LOVIN
Originally released on the Revealed Recordings Miami 2017 sampler, 'Fun Lovin', the impressive coming together of creative minds Taku-Hero & Funk Machine, extends its lifespan with a new remix package. Revealed draw from an impressive host of Revealed regulars for this, namely Quintino, Michael Feiner, and Dropgun, to take the track in new directions and catapult it to the next level.
Revealed stalwart Quintino, fresh from his remix alongside Hardwell and known for last year's successful release on Revealed 'Baldadig', introduces a host of ripping synth lines to the original, that will appeal to fans of a harder persuasion. Michael Feiner, the multi-faceted DJ, producer, singer and songwriter uses his considerable song writing talents to produce a song-based, piano led progressive version that is sure to resonate with radio listeners and ravers alike. Finally, Dropgun, whose collaboration with JAGGS 'Chronos' was a standout track from Revealed's 2016 Festival EP, provide the most melodic of the 3 tracks, with piano also leading the way, alongside other electronic melodies that weave their way intricately through the main hook.
Each remix comes with both an extended and radio version, to complete a rounded package and ensure the remixes spread like wildfire across multiple platforms, from radio airwaves to dancefloors worldwide. With such a diverse and talented pool of remixers on this release, who collectively have been supported by the likes of Hardwell, Galantis, Laidback Luke, Axwell, NERVO, Martin Garrix, Tiësto and David Guetta to name a few, 'Fun Lovin' is set to enjoy a new lease of life, as the track's net is cast further than ever before. Grab a copy when it is released via Revealed Recordings 13th November.
For more info check:
Tweets by RevealedRec


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Status: Open (Call business to confirm holiday hours)
Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
Be the first OregonLive.com user to add photos or videos of Sharis Of West Linn
During our most recent visit to our local Shari's West Linn, our server Kay was exceptionally accomodating. Food was prompt and delicious, coffee fresh and hot, and service accurate and attentive.
Very friendly, fast service!
Throughout the Pacific Northwest, folks have been coming to Shari's for the highest level of friendly hospitality and simply great food, night and day, day after day. When you arrive, you'll be served a hearty meal and a slice of award-winning pie with a big helping of friendly service. No wonder our guests have been smiling continuously for over three decades.
Sharis won first place in the National Pie Contest!! Yummy pies!!!


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|Publication number
|Publication type
|Application number
|Publication date
|Aug 2, 1994
|Filing date
|Jun 3, 1991
|Priority date
|Jun 3, 1991
|Fee status
|Also published as
|Publication number
|Stephen E. Wade
|Original Assignee
|Wade Stephen E
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (12), Non-Patent Citations (2), Referenced by (32), Classifications (13), Legal Events (2)
|External Links: USPTO, USPTO Assignment, Espacenet
This invention was made with Government support under a research grant (No. MH42031) awarded by the National Institutes of Health. The Government has certain rights in the invention.
This invention relates to devices and methods for diffusion of chemical substances, and, more particularly, relates to devices and methods for controlled diffusion of chemical substances of interest intraorally.
Frequently, sampling of biological fluids from a subject, for example to determine the concentration of a substance or substances in the biological fluid for purposes of diagnosis, and/or delivery of drugs to a subject, for example to control delivery rate and/or adequacy of drug level, requires sustained or repeated sampling or delivery over a defined, and often extended, time period.
By way of example, the availability of chemical substances in the body to tissue is often subject to temporal fluctuations, such that a series of samples taken over time from the biological fluid would reveal a distribution of concentration values of the substance. In general, it is the net effect of this temporal distribution of concentration values over some time interval, rather than the value that is observed at any particular moment, that is of interest. One measurement of the net effect of temporal fluctuations in substance concentration over some time interval is the summation of momentary concentration values over that interval, or the "time integral" of concentration. The time integral, divided by the length of the time interval over which it was obtained, results in the average concentration of the substance of interest over that time interval.
The time interval that may be of interest varies according to the context of the measurement, but is frequently on the order of hours. Time integrated measurements on a scale of hours reflect a more enduring state of the organism than measurements representative only of momentary conditions.
Frequently, concentrations of a substance of interest are measured in blood, rather than saliva, since blood is the primary means of transporting most substances within the body. However the concentration of a substance of interest in blood is not always the same as the concentration available to other tissues, the latter typically being of greater interest in diagnostics. This is so because substances must diffuse across cell membranes in order to arrive at other tissues from the blood, and because frequently the substance of interest exists in multiple forms in the blood, not all of which are equally able to cross cell membranes.
In particular, the substance of interest may form associations with other substances (such as proteins) that have much lower ability to permeate cell membranes than has the substance of interest in its free, or unbound, form. In such a case, the concentration of the substance of interest available to tissues other than blood may be much more closely related to the concentration of the free form than to the associated, or bound, forms, or aggregates thereof. Frequently, the bound forms are very much more abundant than the free form.
Moreover, saliva has many advantages as a medium for assessing the concentrations of substances available to tissue in humans. Not only is saliva much more convenient to collect than blood or urine, but levels of many substance of interest in saliva generally reflect the concentrations of the free fractions of those substances in blood plasma. To the degree that saliva concentration of a substance of interest mirrors that of the free fraction of the substance in plasma, the saliva concentration provides more direct information about the availability of the substance to tissue.
There are, however, some significant problems in the interpretation of salivary concentrations of substances. These problems are due to two factors. First, in practice, saliva is often contaminated to some extent with blood or blood plasma, thus including the bound fraction of the substance of interest that is essentially unavailable to tissue. Second, the concentrations of substances in saliva fluctuate over time just as in other body fluids.
Consequently, the interpretation of substance concentrations measured in saliva samples is difficult, since it is generally not known whether there was some degree of blood plasma contamination of saliva, or whether the concentration observed reflected a momentary fluctuation or a longer-enduring state.
It would thus be desirable to provide saliva sampling devices and methods that can be used to obtain a sample of a substance of interest, such that the abundance of the substance of interest in this sample specifically reflects the time integral of the concentration of the free fraction of the substance of interest in saliva (to the exclusion of bound forms) over some known time interval, and that eliminate or minimize measurement inaccuracy caused by blood or blood plasma contamination of saliva.
While devices and/or methods have been heretofore suggested and/or utilized for collecting saliva samples intraorally (see, for example, U.S. Pat. Nos. 4,774,692 and 4,817,632), such devices and methods are not particularly adapted to gathering primarily the substance of interest, rather being directed to gathering saliva samples. Where some filtration of saliva samples has been provided (for example by way of a porous membrane surrounding an osmotically active substance as shown in U.S. Pat. No. 4,817,632), the concentration of a substance of interest derived from analysis of a saliva sample thus collected has no obvious relation to the average concentration of the free fraction of the substance over the interval of use, or even to the concentration of such substance at any identifiable moment within the interval, but instead most closely approximates the concentration present during periods of rapid fluid uptake inherent in such heretofore known devices.
Devices and methods have also been heretofore suggested and/or utilized for the purpose of measuring the concentration of a substance of interest in interstitial fluid, and have therefore been designed to be implantable under the skin of an animal (see U.S. Pat. Nos. 4,798,207 and 4,594,326, by the inventor of the herein disclosed invention). Such devices have of necessity provided means for inserting and withdrawing the binding composition utilized to capture the substance of interest in the device, and required construction utilizing materials compatible with in vivo implantation.
While the device and methods of this invention share many of the general principles discussed in U.S. Pat. No. 4,594,326 (relevant portions of the disclosure of which are incorporated herein by this reference), further improvements to adapt the method therein discussed for use in measuring substances of interest in saliva could be utilized.
In particular, means of accumulating a specific substance of interest intraorally from saliva in such a way that the amount accumulated during some time interval is substantially directly representative of the average concentration of the free fraction of the substance (and thus available to other tissue) in the fluid during that time interval could be utilized. In such a case, it would be desirable that such means not depend upon the net accumulation of saliva fluid, nor be limited by volumetric capacity of a device for such accumulation.
By way of further example (in the case of sustained drug delivery), sustained intraoral delivery of an antibiotic such as tetracycline, for the purpose of treating a periodontal infection or the like, would be desirable. In such a case, therapeutic drug levels could be maintained in the oral cavity over a long period of time. This would be advantageous from the point of view of maintaining adequate drug levels at the site of the infection, without exposing other tissues to such high levels of drug, thereby minimizing undesirable side effects. Devices and methods for such sustained intraoral drug delivery could thus be utilized which regulate the transfer of the drug into saliva.
This invention provides an improved device, and methods of manufacture and use, for controlled diffusion of a chemical substance of interest. The device is particularly well adapted for use in the mouth of a subject, and includes ported structure made of material that is substantially impermeable, an inwardly facing surface of which defines a compartment for receipt of one of the chemical substance of interest and a composition capable of binding to itself the chemical substance of interest. A dispersed layer is formed in the structure of material characterized by limited permeability so that a region of permeability to diffusion of the chemical substance of interest is formed at the port, or ports, in the structure. Means for securing the device within a subject's mouth is connected with the structure.
The material characterized by limited permeability is dispersed in the compartment so that contact is maintained between such material and the inwardly facing surface adjacent to the port after dispersal, a membrane being formed across the port.
The device can be secured in a patient's mouth, for example between the teeth and the cheek, by anchoring the device to a patient's tooth utilizing a securing line attached to the device. In this manner, the device can be maintained in the mouth for extended periods of time, as would be desirable, for example, where time-integrated measurement of the free fraction of a substance of interest in saliva, or where sustained, regulated, oral delivery of a drug, is desired.
It is therefore an object of this invention to provide an improved device and methods for controlled diffusion of a chemical substance of interest.
It is another object of this invention to provide a device and methods for controlled diffusion of a chemical substance of interest in a subject's mouth.
It is still another object of this invention to provide a device and methods for controlled diffusion of a chemical substance of interest in saliva such that the abundance of the substance of interest collected reflects the time integral of the free fraction of the substance in the saliva.
It is yet another object of this invention to provide a device for controlled diffusion of a substance of interest which includes structure substantially impermeable to the substance of interest, an inwardly facing surface of which defines a compartment, the structure having a port therein from the compartment, and a dispersed layer formed in the structure of material characterized by limited permeability, the layer being formed in the structure so that the layer extends from the inwardly facing surface across the port after formation, the layer thereat providing a region of permeability to diffusion of the substance of interest.
It is still another object of this invention to provide a device for controlled diffusion of a chemical substance of interest between saliva in a subject's mouth and the device, the device including structure having an inwardly facing surface which defines a substantially enclosed compartment and having a first, substantially impermeable, region and a second, selectively permeable, region, the second region including a membrane permeable to diffusion thereacross of the substance of interest positioned coextensively with the inwardly facing surface, and means for securing the structure in the subject's mouth.
It is still another object of this invention to provide a method of making devices for controlled diffusion of a chemical substance of interest including the steps of providing structure substantially impermeable to the substance of interest, the structure having an inwardly facing surface defining a compartment and having a port therein from the compartment, and dispersing a material characterized by limited permeability in the compartment so that contact is maintained between the material and the inwardly facing surface adjacent to the port after dispersal, the port and material providing a region of permeability to diffusion of the substance of interest.
It is yet another object of this invention to provide a method of making devices for controlled diffusion of a chemical substance of interest between saliva in a subject's mouth and the device, the method comprising the steps of molding, of substantially impermeable material, a structure having an inwardly facing surface which defines at least a part of a compartment and having a plurality of ports therein from the compartment, forming, in the structure, a membrane across the ports characterized by permeability to diffusion of the chemical substance of interest, and attaching means for securing the device in the subject's mouth with the structure.
It is still another object of this invention to provide a method for controlled diffusion of a chemical substance of interest between a compartment and saliva in a subject's mouth, the method including the steps of providing a device including structure substantially impermeable to the substance of interest, the structure having an inwardly facing surface defining the compartment and having a port therein, the port having material characterized by limited permeability thereacross, the port and material thereby defining a region of permeability to diffusion of the substance of interest, placing one of the substance of interest and a composition capable of binding to itself the substance of interest in the compartment, and positioning the device in the mouth of a subject.
With these and other objects in view, which will become apparent to one skilled in the art as the description proceeds, this invention resides in the novel construction, combination, arrangement of parts and methods substantially as hereinafter described, and more particularly defined by the appended claims, it being understood that changes in the precise embodiment of the herein disclosed invention are meant to be included as come within the scope of the claims.
The accompanying drawings illustrate a complete embodiment of the invention according to the best mode so far devised for the practical application of the principles thereof, and in which:
FIG. 1 is a perspective view of a first embodiment of the device of this invention;
FIG. 2 is a perspective view of a second embodiment of the device of FIG. 1 adapted for use where repeated or constant measurement of the diffused substance of interest is desirable;
FIG. 3 is a sectional view taken through lines 3--3 of FIG. 1;
FIG. 4 is a detailed sectional view of a diffusion port structure of the device of FIGS. 1 or 2;
FIG. 5 is a diagrammatic illustration of a method of manufacturing the device of FIGS. 1 or 2 in accord with this invention;
FIG. 6 is an illustration showing use of the device of FIG. 1 intraorally in accord with this invention;
FIG. 7 is a chart illustrating uptake of a chemical substance of interest present in saliva utilizing the device of FIG. 1; and
FIG. 8 is a chart illustrating measured concentrations of a chemical substance of interest present in saliva and collected utilizing the device of FIG. 1.
A preferred embodiment of device 10 of this invention is illustrated in FIGS. 1 and 3. Interior compartment 12 communicates with the device's immediate environment through multiple diffusion ports 14, preferably arranged in opposing rows on opposite sides of the device. Each diffusion port is formed through shell structure 16 and has a membrane material 18 across the port aperture at a compartment defining the inwardly facing surface 20 of shell 16. Membrane 18 is formed of polymeric material having a limited permeability (i.e., permeable to diffusion of the substance of interest from the immediate environment to compartment 12 or from compartment 12 to the immediate environment) and shell 16 is formed of material which is substantially impermeable, particularly with respect to the substance of interest and other substances found therewith.
Membrane 18, when formed as hereinafter set forth in compartment 12 of shell 16, is a layer of the polymeric material across ports 14 that remains in contact with surface 20 of shell 16. It is felt that the polymeric material in surface contact with surface 20 may, at least in some cases, have properties quite distinct from the properties displayed by diffusion port membrane 18.
Shell 16 includes end closures 22 and 24 and main body 26. Closure 22 typically is made of a similar material as body 26, and is joined to body 26 by, for example when the material is a polymeric plastic, welding through application of heat and pressure to their region of contact. The end result is that closure 22 and body 26 are a substantially unitary structure. Closure 24 may be in the form of a short tube sealed at the distal end, and is of a size so that it is held in intimate and leak-free contact with surface 20 of main body 26 by radial compression of closure 24 upon insertion. It is apparent, of course, that devices may be made with two closures of the same type. Dimensions of the assembled device are approximately 20 to 25 mm overall length, with a 2 to 3 mm outside diameter (1.52 to 2.52 mm inside diameter). Main body 26 without closures is about 15 mm long. The thickness of the tubular wall of main body 26 is approximately 0.24 mm.
In second embodiment 28 of the device shown in FIG. 2, compartment 12 has flow connectors 29 at each end thereof. These connectors are flexible tubes of polymeric material, enabling material in fluid form to be introduced at one end of compartment 12 through a flow connector 29 to consequently displace material from the other end of compartment 12 through the other flow connector 29. The ends of the flow connectors are located at some distant point to facilitate access to the contents of the device without removing the device from the mouth of a subject, as would be useful, for example, in certain research applications where it is desired to make multiple measurements of relatively short duration on a sleeping human subject or for long term administration of a drug to an otherwise incapacitated patient.
Both devices 10 and 28 are preferably provided with means for securing the device in the mouth of a patient. For example, as shown in FIGS. 1 and 3 with respect to device 10, closure 22 may have aperture 30 molded or drilled therethrough for receipt therethrough and attachment (preferably by melting) of securing line 31 (for example, dental floss or other supple line), line 31 being securable to a subject's tooth to secure against loss, swallowing, aspiration, or the like while the device is in the subject's mouth.
Main body 26 is preferably cast in the form of a tube open at each end, and having multiple essentially identical perforations molded into the material to form ports 14. These perforations may be of a variety of shapes. The preferred shape, illustrated in FIG. 4, resembles, in section, a truncated cone with greater diameter port aperture 32 oriented outwardly and lesser diameter port aperture 34 at surface 20 (and being approximately 0.63 mm in diameter). Cylindrical bore portion 36 defines aperture 32, while conical bore portion 38 terminates at aperture 34. The decrease in bore diameter as ports 14 approach surface 20 is valuable in controlling penetration of ports 14 by the membrane casting solution, as described hereinafter.
The provision of thin membrane 18 made integral with the more rigid supporting shell structure 16, and in particular the provision of such membranes at surface 20 thereof when that structure has the general configuration of a tube, provides strength and durability, since the otherwise delicate membrane material is supported by intimate contact with the more rigid supporting material and is protected from casual mechanical damage by its position recessed within ports 14. Such strength and durability is particularly advantageous in the application of device 10 or 28 intraorally.
The best method so far devised for making devices 10 or 28 is described with reference to FIG. 5. Main body 26 and closure 22 are produced by injection molding of polycarbonate resin or other suitable material, utilizing known methods. Radioopacity is achieved by adding a radioopaque material (e.g. barium sulfate) to the resin used for injection molding. These parts may be made of other materials such as stainless steel. However, the nature of the contact between membrane 18 and main body 26 of stainless steel is different, as evidenced by the ability to remove tubular membranes intact therefrom, and the inability to do so when using a polymeric main body capable of solvation in the selected solvents.
A solution of the polymer to be used for the membrane is prepared in appropriate organic solvents. Typically a solution of 4 grams cellulose acetate in 14 grams dimethylformamide (DMF) and 7 grams acetone is used (the solvent composition may be varied from about 3:1 to 1:2 acetone to DMF by weight, polymer:solvent proportions being variable in a range from about 1:12.5 to 1:3 by weight). Solution is promoted by stirring and ultrasonication. Other compositions, polymers and/or solvents as are known in the art may also be advantageously used (for example cellulose propionate, cellulose acetate butyrate, or compositions for forming various polycarbonate membranes).
Membrane-modifying materials are added and dissolved. The solution is then further treated by sonication. Typically, for use with binding compositions in device 10, 8 grams citric acid is added to enhance the strength and permeability to solutes of the membrane. Depending on use, this can be varied in a range from no added material to about 2:1 by weight citric acid to cellulose acetate. Other materials, alone or in combination (such as adipic acid with citric acid to accommodate diffusion of larger molecules such as peptides), may be added to vary the resulting properties. It is possible by such means to change the selectivity of membrane 18, for example for passage of solutes of differing molecular weight.
Multiple lengths of polyethylene (PE) tubing are prepared, roughly 30 mm in length and of diameter such that each can make a friction fit over the outside diameter of molded main body 26. A volume of the cellulose acetate solution is loaded into one of the lengths of PE tubing (tube A), the viscosity of the solution generally being of a degree such that the tubing need not be sealed at its end to maintain the solution in the tubing. An assembly is then constructed by attaching the loaded piece of PE tubing (i.e., the dispersing tube) to one end of main body 26, and an empty piece of the tubing (i.e., the receiving, or exhaust, tube B) to the other end of main body 26. Use of materials other than PE, or variations in the means of attaching such tubes, could be utilized.
Multiple resulting assemblies are each loaded in a separate wooden spindle housing having a recess therein for snugly receiving the assembly, the spindles then being loaded in a centrifuge, oriented so that acceleration generated by the centrifuge will act on the cellulose solution to disperse it from the dispersing tube, through main body 26 and into the receiving tube. The centrifuge is operated so as accomplish this movement over a predetermined amount of time. The accelerations provided by the centrifuge may be programmed to vary in order to shorten or prolong the passage of the material through any part of the assemblies. For example, when using an IEC model UV centrifuge with a rotor radius of 150 mm, the controller is initially set to approximately 600 g. The centrifuge approaches this rate setting gradually, usually within about 1 minute. After about 3 minutes the speed controller is advanced in 3 equal steps at 20 second intervals to approximately 900 g., and at about 7 minutes to approximately 1100 g., braking at about 8 minutes.
The pattern of acceleration in the first 4 minutes seems most significant in terms of final results. Overly rapid acceleration (e.g. to 1000 g. at 3 minutes) leads to incomplete membrane formation across apertures 34 of ports 14 due to insufficient deposit of the solution across inwardly facing surface 20, and thus a high frequency of water-leaking devices. Overly slow acceleration (e.g. to only 400 g. at 7 minutes) leads to thick membranes and thick opaque deposits of material along the inside bore of polycarbonate main body 26. The indicated procedure generally gives about a 90% yield of clear, strong, thin, and leak-free membranes.
The assemblies are recovered from the centrifuge and spindles, and main bodies 26 are transferred to water or another suitable solvent, such as methanol, after removal of the lengths of PE tubing. Upon examination after contact with the water, each port 18 in main body 26 will be found to have a thin layer of polymeric material thereat thus together defining regions of selective permeability.
The use of a centrifuge or other appliance to generate a controllable accelerative force that acts upon the volume of solution in the assembly to regulate the flow of this solution at surface 20 across which the solution is being dispersed enables advantageous control over the properties of resulting membrane 18.
For example, the thickness of the membrane deposited may be controlled, in general a greater acceleration producing a thinner membrane from a given casting solution. Similarly, a polymer solution that might otherwise be useless for the purpose of producing membranes because of disadvantageous flow properties may be advantageously used to produce membranes when its flow properties are manipulated by application of appropriate acceleration. In addition, the advantageous properties of the device described here, in particular membrane strength, uniformity and permselectivity, are thought to be at least in part a result of the process herein described.
The product of the process just described is in the form of a tube incorporating diffusion ports, with the tube open at both ends. Closure 22 is installed utilizing an appliance that presses the two parts together in their appropriate orientation and heats the zone of contact so that the parts melt and fuse together. Upon cooling a strong welded bond is made.
Closure 24 is preferably a tube of soft vinyl material, having an outside diameter sufficient to make a snug and leakproof interface with surface 20 of main body 26 upon manual insertion thereinto. This tube can serve as a means for introducing a drug, or the binding composition described hereinbelow, into shell 16 whereupon closure 24 is completed by heating and clamping the distal end of the tube so that shell 16 is entirely closed. The appliance utilized to install closure 22 may be configured to also load the drug or other composition and seal closure 24 in a single step. Securing line 31 is then affixed.
It is to be realized that closures 22 and 24 could be eliminated utilizing a process whereby the ends of main body 26 are collapsed, or pinched closed, and heat sealed, the ends being thereby somewhat enlarged in one dimension.
Of course, where device 28 of FIG. 2 is being constructed, flow connectors 29 are attached (and clamped until ready for use) rather than closures 22 and 24, device 28 typically not being precharged with a drug or binding material.
This method thus establishes membrane 18 at each diffusion port 14 and accomplishes the integral sealing of this membrane component to surface 20 of shell 16 by applying a chemical treatment uniformly, rather than differentially. The application of a chemical treatment uniformly, rather than differentially and selectively as to the regions that are to contain diffusion ports, represents a great advantage in simplicity of construction.
Where polymeric material is utilized to make main body 26 of shell 16, the resulting product is not felt to be merely two juxtaposed layers of material in the impermeable regions, with a single layer of material in the selectively permeable regions at the diffusion ports. Rather, it is now thought that multiple layers of material are not exhibited in the regions of inner wall 20 after dispersal of the membrane material, and that the inner wall in these regions may undergo as a result of treatment some physical or chemical modification, the precise character of which is unknown, but which is thought to result from resolvation (i.e., the polycarbonate material can be etched by the solvents utilized in the described method of making the membrane solution), or some other similar chemical or physical agency in the region of contact.
Where device 10 or 28 is utilized to collect a substance of interest from the saliva of a subject, a binding composition is utilized which determines the specificity and capacity for measurement of the completed device (for example when a binding composition is used as described in U.S. Pat. No. 4,594,326). Since such methods are adaptable to measurement of a great number of substances of interest, the description presented hereinbelow is illustrative of only a few such measurements, others being readily apparent to those skilled in the art. In the examples that follow, the use of an antibody based binding composition is described that can be adapted to measurement of any chemical substance of interest for which a suitable antibody can be found, as is the use of certain whole cells, and of non-antibody, non-protein binding composition for measuring the sex steroids testosterone, progesterone, and estradiol.
The naturally occurring carbohydrate molecule called beta-cyclodextrin has the ability to form noncovalent complexes with certain organic molecules of appropriate size, shape, and polarity. The strength of association of such complexes in the case of the sex steroids testosterone, progesterone, and estradiol was found to be such that a polymer or copolymer incorporating beta-cyclodextrin can serve as a useful binding composition in the practice of the method described in U.S. Pat. No. 4,594,326. Specifically, a beta-cyclodextrin copolymer (obtained from American Maize Co., Hammond, Ind.) is dried and ground to a powder, and the powder is wetted with water to form a slurry that is loaded into device 10 or 28 as described above.
The characteristics of the thus loaded device for uptake of the sex hormones testosterone, progesterone, and estradiol have been found useful in measuring these substances in human saliva over a period of several hours. However, the specificity of the binding composition is such that the related steroid hormone cortisol can not be measured simultaneously. However, neither did cortisol interfere in the measurement of the other steroids.
It is anticipated that other compounds beyond those named above can be measured using beta-cyclodextrin preparations as a binder, and indeed that related cyclodextrins, such as alpha-cyclodextrin and gamma-cyclodextrin, can be used advantageously in the measurement of these and related compounds. This is advantageous in that cyclodextrins are less expensive to prepare and more stable in storage than, for example, the antibodies that are described hereinafter.
It is well known that certain whole cells have the property of responding to hormone exposure with readily-detectable biochemical changes. Such cells may be harvested from among naturally occurring microbes, or can be produced by genetic engineering as described by Pons et al. (BioTechniques 9:450-459, 1990). Use of such cells, or components of such cells, as binding compositions in the present invention may allow the cellular response to hormone exposure to be used as the measure of hormone accumulation. This would advantageously simplify the analytical procedure required in order to measure the amount of hormone accumulated by device 10 or 28.
As a specific example, it is anticipated that cells produced according to the method of Pons et al., and thus having the ability to express the enzyme firefly luciferase only in the presence of the hormone estradiol, and in fact capable of expressing increasing firefly luciferase activity in proportion to increasing degrees of estradiol exposure, could be used as a binding composition for estradiol in the practice of the current invention. After appropriate exposure of device 10 or 28, the amount of accumulated estradiol could be approximately measured by providing appropriate conditions for measuring the activity of the firefly luciferase enzyme induced in the cells by estradiol exposure. This would typically be done by providing an appropriate substrate (e.g. luciferin) and measuring light output, as with a sensitive camera or photometer (as described by Pons et al.).
Generally, the use of an antibody preparation as a binding composition allows the measurement of any substance of interest to which an antibody can be found or produced. This includes the majority of all known hormonal and drug substances. The antibody preparation may be obtained as serum from an animal appropriately immunized, from a culture of tissue, or by other biotechnical means. In the example below, the source of the antibody is serum from an immunized animal.
Where the corticosteroid hormones are to be measured, it is desirable to remove all measurable traces of such compounds from the binding composition. This can be done conveniently in two stages. First, corticosteroids are displaced from binding proteins by addition of a relatively large concentration of a substance that is more weakly bound by those binding proteins. Then the displacing substance is removed by adsorption onto a suitable material.
The displacement step can be accomplished by dialyzing the serum against a buffer containing a large excess of a suitable compound, such as progesterone. For efficiency this can be done using a specialized diafiltration apparatus (such as the Column Effluent Concentrator made by the Amicon Division of W. R. Grace, Danvers, Mass.). The adsorption step can be accomplished by placing the dialyzed serum in contact with a resin such as Amberlite XAD-2 (produced by Rhom & Haas) for many hours. Other preparations may suggest themselves to those skilled in the art.
Upon loading of the binding composition into device 10 and sealing of closure 24, the device is complete and ready for use, some examples of which follow including some in vitro experiments that help to characterize the performance of a corticosteroid-measuring device of this invention, and some preliminary in vivo experiments that illustrate its application in human subjects.
30 ml of saliva was collected from one subject over the course of about one hour. Blood samples were drawn from the subject using EDTA as the anticoagulant. Plasma was separated immediately. Tritiated cortisol (3H-cortisol) was added to both plasma (0.28 uCi/ml) and saliva (0.014 uCi/ml). The plasma was loaded into a dialysis bag (Spectrapor #4, Spectrum Medical Industries, Los Angeles, Calif.) and dialyzed for 16 hours at 20� C. against the saliva. After this extensive equilibration, whole saliva containing 3H-cortisol was aliquoted to polypropylene vials in 6 replicate volumes of 3 ml. Two of these replicates received 30 ul additions of equilibrated plasma (1% v/v), two received 150 ul equilibrated plasma (5% v/v), and the remaining replicates were uncontaminated with plasma. Devices 10 were incubated (2 per vial) in each preparation, for 3 hours at 20� C. The devices were then recovered and the accumulated radioactivity was determined by liquid scintillation counting. The 3H-cortisol concentration in each vial was likewise determined. The resulting data were examined to determine the effect of blood plasma contamination upon uptake of 3H-cortisol from saliva.
The blood plasma contained 28 times as much 3H-cortisol per unit volume as saliva against which it was extensively dialysed. Addition of equilibrated plasma to saliva at 1% v/v caused an increase of about 35% in total tritiated cortisol (3H-F). Plasma contamination of 5% more than doubled the total 3H-cortisol content. However, as shown in Table 1, performance of the devices was completely unaffected by blood plasma contamination of saliva.
TABLE 1______________________________________Degree of 3H-F activity 3H-F uptakeplasma contamination nCi/ml nCi______________________________________0% 13.6 0.834 (0.082)1% 18.4 0.733 (0.039)5% 31.8 0.728 (0.027)______________________________________
Lack of effect of blood plasma contamination of saliva upon device uptake of tritiated cortisol (3H-F). The distribution of 3H-F between plasma and saliva was equilibrated before the experiment began (see text). The uptake of 3H-F is cumulative over a period of 3 hours at 20� C. (mean and standard error for 4 devices).
In order to test the capacity of the devices of this invention to accurately integrate extreme changes in hormone concentration, we measured uptake performance of device 10 under three conditions: 1) low, constant cortisol level, 2) high, constant cortisol level, and 3) a single brief pulse of high cortisol concentration against a background of low cortisol concentration.
A buffer containing cortisol with a trace amount of 3H-cortisol at constant specific activity was prepared, containing either 2.8 nmol/L or 28 nmol/L of total cortisol (F). These concentrations correspond to saliva cortisol concentrations observed under low baseline conditions and following pharmacological stimulation, respectively. Devices 10 were incubated under either constant conditions (2 hours in one buffer), or with a transition from low to high cortisol after 1 hour, with a return to the low cortisol environment after 30 min. The transitions were substantially instantaneous. The average cortisol concentration experienced by devices in the "pulse" condition was 9.0 nmol/L. Data were analyzed by plotting cortisol uptake as a function of average cortisol concentration, and examining the colinearity of uptake under the constant and pulsed conditions.
The devices responded accurately in representing the average hormone availability produced by a single brief and extreme pulse of cortisol in the environment. FIG. 7 shows that the data from the pulse condition are superimposable upon the response function determined by performance under the two constant conditions (r=0.995). In FIG. 7, cortisol uptake is expressed in picomoles. Each point represents the response of a single device 10.
Five healthy normal subjects (two female) were recruited (after advisement and informed consent) for a three-day study of corticosteroid variation between the morning and afternoon of a typical work day.
Subjects were issued a package of 12 of the device 10 and were shown how to position and secure each device by wrapping dental floss securing line 31 around tooth 45 as illustrated in FIG. 6. In practice, the subject grasps dental floss securing line 31 attached to device 10 with the thumb and a finger of each hand, one hand near its free end, the other hand about 2 cm from its attachment to device 10. Line 31 is then passed between teeth 45 and 47 at the side of the mouth, much as when floss is used for the purpose of cleaning between teeth, in such a way that device 10 is outside the teeth and adjacent to cheek 49. The free end of line 31 is then passed again in the space between teeth at another site, either toward the front or toward the back of the mouth from the first site. The distance between device 10 and the teeth is regulated to 2 to 3 cm by pulling on the free end of the floss. Finally both passages are repeated, with the result that the floss is wrapped entirely around tooth 47 approximately one and a half times. The excess free floss is then preferably removed with scissors. The choice of which tooth or teeth to use for anchoring, and the exact length of floss to be maintained between the teeth and device 10, is left to the discretion of the subject.
Devices are easily removed after use by grasping line 31 near its attachment to the device and pulling smoothly. Use of device 10 without line 31 is of course possible, but is usually not preferred because of the potential for loss of the device.
Subjects were instructed to install 2 devices 10 (one on each side of the mouth) for two hours sometime during the interval between 0700 and 1100 hours, recording the exact times of installation and removal. Similar measurements were made during the interval between 1300 and 1700 hours. Upon removing the devices, subjects rinsed them in tap water and placed them (pairs together) in screw-capped vials containing methanol. Subjects accumulated 6 sample vials and returned them for analysis after the third consecutive day of sampling. The methanolic extracts of devices 10 were differentially analyzed for corticosteroids by an ultrasensitive HPLC method, which involves forming fluorescent esters of the steroids by reaction at the 21-hydroxy position with anthroyl nitrile. The average saliva concentration (X) corresponding to the reported duration of use (D) and the measured steroid content (C) was calculated using an uptake constant (k) of 0.035 ml h-1 (i.e. X=(C/D)/k) . The variation of integrated saliva corticosteroid concentration from morning to afternoon, and differences among subjects, were studied by analysis of variance (ANOVA).
All five subjects completed the protocol, and none reported any discomfort in using devices 10 as instructed. Of the 30 potential observations, 2 from 1 subject and 1 from another subject were lost due to negligent timing. All the missing observations were in the afternoon time period. FIG. 8 represents saliva corticosteroid (cortisol+cortisone) concentrations (nmol/L) measured in the human subjects over 3 days. The upper panel shows morning (0700-1100 hours) values, while the lower panel shows afternoon (1300-1700 hours) values (a significant drop in corticosteroid concentrations from morning to afternoon (F(1,17)=13.35, p<0.002) being notable). Each point represents a single measurement based on a 2 hour integration.
When device 28 is used, for example when it is desirable to make multiple sequential measurements of saliva concentrations of a substance, or when long term drug delivery is desired, without requiring the subject to repetitively install and remove devices 10, tubing 51 of flow connectors 29 are passed from the corner of the subject's mouth and secured to the cheek with adhesive tape, and further extended and taped to the back of the subject's neck. The tubing is further extended from the subject to the bed in which the subject is confined, finally terminating at a convenient distance so that the ends of the tubing can be accessed by research or medical personnel. Thus, successive measurements can be started and stopped respectively by introducing and removing an appropriate binding composition to device 28 through the attached tubes, or long term drug delivery can be accomplished.
Where the devices of this invention are used in providing sustained delivery of drugs within the oral cavity, for example of antibiotics or the like, compartment 12 of device 10 or 28 would be filled not with a binding composition, but with a drug composition. Diffusion of the drug from compartment 12 of the device into the saliva would follow the same diffusion laws already described, the precisely defined and limited diffusion pathway provided through membranes 18 and ports 14 regulating the rate of transfer of the drug composition to the patient.
As may be appreciated from the foregoing, improved devices and methods for controlled diffusion of chemical substances of interest are provided, the device and methods being particularly well adapted to diffusion of the chemical substances of interest in a subject's mouth.
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|Method of extracting human saliva
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|Cellulose acetate tubular membrane , Chemical Abstracts, 87:24360.
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|Ophthalmic implant for delivering therapeutic substances
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|Engebretson Daniel Scott
|Semipermeable membrane-based sampling systems
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|Galderma S.A.
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|Dakota Technologies Inc
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|U.S. Classification
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|International Classification
|Cooperative Classification
|European Classification
|Aug 2, 1998
|Lapse for failure to pay maintenance fees
|Oct 13, 1998
|Expired due to failure to pay maintenance fee
Effective date: 19980802


text:
'What in your life is calling you? When all the noise is silenced,
the meetings adjourned, the lists laid aside...what still pulls on your soul?'
--Terma Collective, "The Box"
I dare you to listen. Harder and longer than you ever have. And then I dare you not to smile. The magic has always been right here. Inside you. Waiting for you to give it wings.


text:
Lot 40 Marble Island RoadColchester, VT 05446MLS Number 4373438
- Price: $225,000
- Est. Mortgage of $/month
- 1214 Days on Market
- 1.05Acreage
- 45738Square Feet
- UnknownFlood Zone
- AssignedElementary School
Great Lakeviews from this upper lot! Outer Bay at Marble Island is nothing short of paradise nestled on the shores of Lake Champlain. The 63 acre peninsula is fondly remembered by the residents of Colchester, Vermont as a popular summertime destination. Marble Island remains home to many seasonal cottages and year round residences. Today, this spectacular community features twenty-one waterfront Townhomes and 40 home sites in four distinct neighborhood-like settings, with 3 beaches and an adjacent marina. Build packages available or bring your own builder.
Ask A Question
More Info
Basic Information
- MLS Number4373438
- p mod date time2014-07-24T15:34:00
- Modification Date01/18/2017
- StatusACT
- Date Listed2014-07-23T00:00:00
- List Price$225,000
- AmenitiesBeach Rights, Boat Slip/Dock, Common Acreage, Docks, Dry Dock
Water Body
- Water Body NameLake Champlain
- Water Body TypeLake
- Shore RightsCommunity, Deeded, Lake Access
- Water AccessTown Residents Only
- Number of Photos3
- Building NumberLot 40
- Zip05446
- TownColchester
- StateVT
- SubdivisionOuter Bay @ Marble Island
- ZoningResidential
- Flood ZoneUnknown
- CountyChittenden
- Elementary SchoolAssigned
- Topography
- Alternative Lots Avail
- Lake Frontage
- Mountain View
- View
- Walking Trails
- Water View
- Waterfront
- Junior HighColchester Middle School
- High SchoolColchester High School
- StreetMarble Island Road
- Docs AvailablePlat/Grid Map, Survey
- Broker NameColdwell Banker Hickok and Boardman
- Current UseResidential
- RoadsCul-de-Sac, Paved, Public
- AVMNo
- Agent NameBoardman
- Acreage1.05
- Square Feet45738
- Road Frontage1
- Lot31
- Property TypeLand
- WaterPublic Water - On-Site
- ElectricOn-Site
- SewerUnknown
- UtilitiesCable - At Site, High Speed Intrnt -Avail, Telephone Available
- Taxes$1,810
- Tax ReductionYes
- FinancingAll Financing Options
- SurveyedYes
- Tax Yr14/15
Your Local Office
Copyright 2017 Northern New England Real Estate Network, Inc. All rights reserved. This information is deemed reliable but not guaranteed. The data relating to real estate for sale on this web site comes in part from the IDX Program of NEREN. Subject to errors, omissions, prior sale, change or withdrawal without notice. This web site is updated daily.
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text:
New Rainbow Vision Spinner eGo Variable Voltage Battery- 1300mAh
Product Introduction
New Rainbow Color Vision Spinner 1300mAh eGo Variable Voltage Battery comes with 510/eGo threading, it works with a variety of 510/eGo threaded atomizers, tanks systems, and clearomizers/cartomizer.
The battery allows you to adjust voltage output from 3.3v to 4.8v by spinning the knob at the bottom.
Size (length*diameter): 113*16mm
Power Capacity: 1300mAh
Operating Voltage: 3.3V-4.8V
This product comes with
- 1pc New Rainbow Vision Spinner 1300mAh eGo Variable Voltage Battery
Simple packing. Customary packing from the factory, the packing is subject to change without notice.
Embedded power button, CE cartificate mark. New appearance with new packing. The new designed Vision logo is printed on the battery body.
Main features
1. Rainbow color.
2. It comes with eGo thread.
3. 650mAh, 900mAh also available.
4.Variable Voltage: 3.3V-4.8V
1)Turn on/off the battery
Generally, the battery is shipped in the off position. In off position, it will not function even when pressing the button. To turn on battery, press manual button 5 times within 2 seconds. You will see white LED flash. To turn off battery, press manual button 5 times within 2 second as well, the white LED will flash! "5-click protection" can protect the battery from being activated when you do not want or do not use it. No more firing in your pocket!
Connect the Micro-USB cable to a computer or an AC-USB adapter into a power outlet to charge the battery. The battery icon will run up from current display repeatedly. Full frames display shows the battery is fully charged.
- It comes with ego thread, compatible with 510/ego thread cartomizers or chargers.
- CHARGER NOT INCLUDED. It can be charged via the exclusive Vision USB charger.
- Using the battery at a higher voltage output will drain the battery faster than at a lower voltage. We suggest you to start with a low voltage and increase the voltage gradually until you find the right voltage for your atomizer/cartomizer.
- There is CE mark on the battery body.
Pls check Guarantee Policy. 6 months


text:
Jeffers22 18:04 19 Jan 2005
Not enough info really. What OS and what level of updates/service pack installs? Is it software RAID or via a RAID Controller Card, or is RAID built into the Mobo? IDE or SATA? Were the drives formatted before you installed them? If so, how?
Out of interest, what made you choose RAID 0?


text:
AMINTA'S STORY: Part 1. This is Aminta. She lives in a village near here and is a lot like you. She is worried. What do you think she is thinking about?. You are right!.
Related searches for AMINTA'S STORY: Part 1
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
She lives in a village near here and is a lot like you.
She is worried.
What do you think she is thinking about?
One of her big concerns is her children. She would like them to go to school but she can't afford the notebooks and pens they need. She would also like them to have better food.
She wants to use the money to start a small enterprise from which she can get an income.
She decides she will make tie-dyed cloth like her sister-in-law.
"I will make 5 pieces of cloth and sell them for 2,500 each. Then I will make 12,500."
She is very excited about her idea.
Next day Aminta goes to town and stops at the first store she comes to.
She buys the supplies she needs and is surprised to find she has to use all her savings. So she has to walk home.
It takes a long time as she has never done tie-dying before.
What is happening here? she comes to.
Why is her husband upset?
What could Aminta be thinking?
Aminta hoped to make 12,500 by selling 5 pieces of cloth. What can she see?
How much will she be able to make now?
How much has she already spent?
What do you think she should do?
How many pieces of cloth will she be able to sell?
Aminta gets up early next morning to go to the market. What can she see?
What does she see when she gets there?
What do you think she is saying to herself?
Aminta sits in the market all day. People bargain with her.
Eventually she sells each piece of cloth for 800.
She is very discouraged and can't understand how her big idea went so wrong.
Next day she asks her friends.
What do you think they are saying to her?
How could she have avoided all these problems?


text:
"I will fly in the greatness of God as the marsh-hen flies,
In the freedom that fills all the space 'twixt the marsh and the skies." — Sidney Lanier, American poet, in the poem The Marshes of Glynn
Flying, like any new perspective, affords one the opportunity to to study the beauty of the moment. Tired old perspectives lead to tired, fixed opinions. As a student of the beauty of the moment you have the privilege of seeing and knowing the liberty of the almighty.
*Photos taken over Lake Sidney Lanier and northwestern Georgia by Gregg Hake with an Apple iPhone 3GS


text:
Just Tease Kat Dee is displaying her contours in a tight and short black gown. Her gown is so brief it scarcely covers her round ass! Gradually she glides her spruce up and also over her head. Once it's lastly off she postures partially nude. Nice tits! Inspect out Simply Tease for more sexy photos of women in as well as out of lingerie, outfits, stockings as well as socks. Whole lots of fetishes inside this site!
Only Tease Kat Dee Sexy Black Dress movies big tits
Categories: Girls


text:
2017 Vendors
- A Mermaid's Harvest
- AlpacaJoy of Maryland
- APH Designs
- Backyard Fiberworks
- Crabapple Yarns
- Cynthia Crane's Pottery
- Dancing Leaf Farm
- Dragonfly Fibers
- Duck Duck Wool
- End of the Row Yarns
- Feederbrook Farm
- Flying Goat Farm
- Hipstrings
- Hobbledehoy Yarn and Fiber
- Kate's Cauldron
- Lattes & Llamas
- MarigoldJen Hand Dyed Yarns
- Metis Industries
- Neighborhood Fiber Co.
- Rajkovich Designs
- Rising Tide Fiber Co.
- Snallygaster Fibers
- SpaceCadet
- StarKnits
- Taylored Fibers
- Tempting Ewe Yarns Inc
- That Clever Clementine
- The Woodrasp Shop (no website)
- Threeravens Fiber Studio
- Wandering Wool
- Wild Hare Fiber Studio
- Wolles Yarn Creations
2017 Sponsors
Blog Archive
- ► 2017 (61)
- Sponsor Post: The Yarnicorn
- Thank you for another great Yarn Party!
- Classes, Door Prizes, Charity, and the popular Lon...
- Sponsor Profile: The Knitting Loft
- Sponsor Profile: The Yarnicorn
- Sponsor Profile: The Yarn Spot
- Sponsor Profile: Noni
- Sponsor Profile: Blended Threads Workshops
- Sponsor Profile: Cloverhill Yarn Shop
- 2014 Maps and Venue Information
- Sponsor Profile: The Knitting Boutique
- 2014: Wolle's Yarn Creation
- 2014: Wandering Wool
- 2014: Wild Hare Fiber Studio
- Sponsor Profile: Two Rivers Yarns
- 2014: Unplanned Peacock Studio
- Sponsor Profile: Nature's Yarns, Inc.
- 2014: Threeravens Fiber Studio
- 2014 Charity Collection
- Sponsor Profile: Looped Yarn Works
- 2014: The Verdant Gryphon
- Sponsor Profile: Second Story Knits
- 2014: The Camel Shoppe
- 2014: That Clever Clementine
- 2014: Tempting Ewe Yarns, Inc.
- 2014: Taylored Fibers
- 2014: StarKnits
- 2014: SpaceCadet
- 2014: Snallygaster Fibers
- 2014: Slippery Slope Farm
- Sponsor Profile: Fibre Space
- 2014: Shalimar Yarns
- 2014: Rajkovich Designs
- 2014: Neighborhood Fiber Co.
- 2014: Kate's Cauldron
- 2014: Gourmet Stash
- 2014: Folly and Nonsense
- 2014: Folktale Fibers
- 2014: Flying Goat Farm
- 2014: Feederbrook Farm
- 2014: Duck Duck Wool
- 2014: Dragonfly Fibers
- 2014: Dancing Leaf Farm
- ▼ March (43)
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Thursday, March 20, 2014
Sponsor Profile: The Yarnicorn
1. What is your website? Email?
Website: www.TheYarnicorn.com
Facebook: facebook.com/TheYarnicorn
Email: firstname.lastname@example.com
Twitter: @TheYarnicorn
Pinterest: http://www.pinterest.com/theyarnicorn/http://www.pinterest.com/theyarnicorn/
2. What kinds of things do you carry?
The shop will launch in August 2014, and will carry batts, top, roving from local mills, locks, sparkle, rolags, handspun yarn, hand-dyed millspun yarn, wool wash, fiber tools and more. In addition, there will be lots of tutorials, giveaways and reviews on the blog and Facebook page.
3. How long have you been in business, and what inspired you to open your business?
I started my first business, BabesterArts, on a whim. Like most who venture down the rabbit hole of spinning, I was totally smitten by the art. After a few years of shop ownership, I decided to rebrand BabesterArts as a kid-centric shop, and started working toward the launch of The Yarnicorn, which will be my yarn and fiber shop. Having spent a few years in business for myself, I now have a much better idea of what works and what doesn't, and my art has improved a great deal. I hope to continue to learn and refine my work as I launch the new shop, and am really looking forward to sharing what I've learned so far.
4. What's your favorite thing about owning your business?
I think my favorite thing is also the hardest thing: the lack of rules. It's wonderful to have complete freedom to make and sell whatever interests me, and to work when and how I please. It's also terrifying! It takes a lot of courage to open a shop of any kind, and an extra dose of courage to sell handmade art. I don't have a business degree, so there has been a lot of "on the fly" knowledge acquisition. Learning over the past several years to self-critique, review, and edit my work has been a great development for me, personally and professionally. Thankfully, I've also developed many wonderful connections to the fiber arts community, and have had the gift of several great mentors.
While I would love to say that I have found a clear definition of my art and my work, I feel I'm still pushing my limits and looking for my own distinct style. Sometimes, that means breaking the fiber/spinning/color rules, sometimes it just means staying up way past my bedtime. There is so much to learn and experience in the fiber arts; I'll never be bored! I work hard, but I also try to keep my sense of wonder and playfulness. Working with fiber can be magical, and I look forward to sharing my enthusiasm for the art with other fiber lovers. Doing all that while running a business that supports my family AND having as much fun as I do probably breaks all the rules, and I love it!
Posted by Homespun Yarn Party at 2:30 PM
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text: I am a brand new forum member. I have been visiting for awhile. I am a Blackberry convert - still have my original Storm 1. My S1 was having increasing problems, I needed wifi, and was ready to stop the misery of multiple battery pulls per day. I tried the Droid and was hooked. I appreciate all of the information on the forums. I am not a techie but have been able to get my phone set up and and download the apps I need. I love my Droid and have no plans to go back to the Bberry.


text:
Contact Info / Websites
Movie Trophies
2016 Submissions
FIRST ENCOUNTER | CREEPJAM Rated Stars Entry for Creepjam 2016 Other DAMIEN & DEZZ |EPISODE 3| EMBARRASSED Rated Stars Levi finds that he has hidden feelings for Dezzy. Comedy - Original DAMIEN & DEZZ |EPISODE 2| LIPSTICK Rated Stars Second Episode of the Comedy Series Damien & Dezz! Comedy - Original
2014 Submissions
DAMIEN & DEZZ |EPISODE 1| CHICKEN GUN Rated Stars The Six Idiots' relaxing day at te beach house is interrupted! Comedy - Original DAMIEN & DEZZ | THEME SONG Rated Stars Theme Song for the upcoming Damien & Dezz series! Comedy - Original QUEXSFLOUP |EPISODE 1| PART 2 Rated Stars The second part of the Quexsfloup story and the conclusion to the intro. Comedy - Original QUEXSFLOUP |EPISODE 1| PART 1 Rated Stars A JComX animation about the crazy world of Quexsfloup. Comedy - Original