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The objective of this review was to analyze components of the vitamin D and their potential in preventing and treating colorectal cancer. The active form of vitamin D, 1α25 (OH2) D3, targets the wnt/β-catenin pathway by up regulating key tumor suppressor genes such as e-cadherin, which promotes an epithelial phenotype, but this effect is only useful when the vitamin D receptor (VDR) is present. Colorectal cell lines have shown that VDR expression levels decrease in the later stages of colon cancer. In colorectal cancers with low VDR expression, treatments could target the genomic and epigenomic level alterations to increase VDR expression through modulating transcription factors such as SNAIL1 or utilizing histone deacetyltransferases (HDAC) inhibitors, respectively. Finally, epidemiological studies suggest that the current RDA should be raised to 2000IU in order to raise serum 25(OH)D3 levels above 30ng/ml, this increase in vitamin D status can most efficiently be obtained from sun exposure or vitamin D supplementation. In summary, vitamin Dand its metabolites could be utilized for treatment and preventive strategies for colon cancer.
According to the American Cancer Society, colon cancer is the third most commonly diagnosed cancer and the third leading cause of cancer death. Colon carcinogenesis begins with the development of adenomatous polyps, which are usually benign but if left untreated or undetected can develop into metastatic cancer. As with most cancers, colon cancer exhibits disrupted signaling. One of the key pathways that is disrupted in colon cancer is the wnt/β-catenin signaling pathway, which is often regarded as part of the initial event leading to colon cancer 1, 2. In a normal cell, the wnt/β-catenin signaling pathway is tightly regulated. β-catenin is normally regulated by the phosphorylation of the NH2 terminal region by glycogen synthase kinase-3β (GSK3). The cytosolic proteins axin and adenomatous polyposis coli (APC) are required for GSK3 to properly phosphorylate β-catenin, which can then be targeted for degradation 3–5. In colon cancer, the wnt/β-catenin pathway is disrupted due to mutations in β-catenin or APC; for example, APC is mutated in 80–90% of colon cancers 6. These mutations prevent the phosphorylation of β-catenin and contribute to its accumulation in the cytosol of the cells, un-phosphorylated β-catenin then is able to migrate and accumulate in the nucleus7, 8. Once in the nucleus, β-catenin dimerizes with DNA-bound T cell factor (TCF1–4), which lead to the expression of genes (e.g., c-myc, cyclin D1) capable of inducing the transformation of normal cells into an oncogenic phenotype 9–12. Recent research has suggested that components of the vitamin D pathway can modulate the unregulated wnt/β-catenin signaling.
Vitamin D3 (cholecalciferol) is a fat soluble vitamin that can be obtained both endogenously and exogenously. Mammals have the ability to generate vitamin D3 by exposing the skin to ultraviolet light, which causes7-dehydrocholesterol to convert into vitamin D3. Alternatively, mammals can obtain vitamin D3 from dietary sources, specifically dairy products13. In order to form the active form of vitamin D3, 1α25-dihydroxycholecaliferol (1α25 (OH2) D3), vitamin D3 is hydroxylated by 25-hydroxylase and 1α hydroxylase in the liver and kidney, respectively14. 1α25 (OH2) D3 can then act as a steroid messenger to carry out multiple cellular functions by mediating its effects through the vitamin D receptor (VDR).
Unbound 1α25 (OH2) D3 can enter a cell and bind to a VDR present in the cytoplasm or the nucleus15. VDR is classified as a class II nuclear receptor, and can heterodimerize with retinoid X receptor (RXR). Once this heterodimer is formed, it can bind to the vitamin D response elements (VDREs), which are located in the promoter region of key genes 16. Many vitamin D target genes have been found to regulate cell cycle arrest and cell differentiation, p21, p27, and e-cadherin 17, 18. Therefore, it has been proposed that 1α25 (OH2) D3 can possibly be used as a therapeutic for cancer by mediating its effects through the VDR and up-regulating the above genes.
The above processes require the presence of VDRs. VDRs are expressed in normal colonic cells, but it has been shown that VDR expression levels decrease in the later stages of colon cancer; the mechanism behind this phenomenon is not fully understood 19. Therefore, treatment with 1α25 (OH2) D3 may not be as effective in the later stages of colon carcinogenesis. It has been suggested that both genomic and epigenetic modifications might be involved in the reduction of VDR expression. 20–25 For instance, Malinen et al. demonstrated that the down regulation of 25 (OH)D3 due to HDACs can be overcome with the use of HDAC inhibitors. 26 Furthermore, it is proposed that an individual could reduce their risk to colorectal cancer approximately 30–50% by either increasing vitamin D intake to 2000 IU/day or increasing their sun exposure to raise blood levels of 25 (OH)D3 to greater than 30 ng/ml 27. Recently, case control studies have shown an inverse relationship between serum 25 (OH)D3 and the incidence of polpys or adenomas in the colon.28, 29 Taken to gather, these studies suggest that a greater understanding of the protective molecular actions of vitamin D against colon cancer should be pursued. The purpose of this paper is to determine how better treatments and preventative strategies for colorectal cancer might be developed utilizing components of the vitamin D pathway.
The wnt/β-catenin signaling pathway is highly unregulated in most colon cancers due to the over expression of cell division/metastatic genes by accumulated β-catenin, contributing to a highly proliferative undifferentiated cell phenotype 30. Recently, it has been shown that 1α25 (OH2) D3 promotes the differentiation of colon cancer cells by stimulating e-cadherin and inhibiting β-catenin signaling 18. E-cadherin is a key protein that is involved in the adhesion properties of epithelial cells 31, 32. The loss of e-cadherin is associated with the modulation of a normal epithelial cell phenotype to a more invasive metastatic phenotype; therefore, it is considered a tumor-suppressor 33, 34. However, β-catenin is considered a proto-oncogene because if unregulated it could contribute to the constitutive transcription of cellular proliferative genes 35. In Palmer et al., investigators used SW480 cells, a well characterized human colon cancer cell line, to determine the effects of 1α25 (OH2) D3 on e-cadherin and β-catenin 25. The SW480-ADH colon cancer cells express low levels of e-cadherin and accumulate elevated amounts of nuclear β-catenin. In addition, Palmer et al. showed that with the addition of 1α25 (OH2) D3 the VDR positive SW480 (SW480-ADH) cells developed a differentiated phenotype by increasing the mRNA expression of e-cadherin and accelerating the translocation of β-catenin from the nucleus to the cytoplasm. Moreover, 1α25 (OH2) D3 decreased β-catenin-TCF-4 transcription activity by increasing ligand-activated VDR 25. Mariadson et al. also demonstrated that the down-regulation of β-catenin-TCF interaction is related to the differentiation of colonic cells 36. The above experiments have been repeated in a sub-line of SW480 cells. The SW480-R cells express residual levels of VDR compared to the SW480-ADH cells, so the addition of 1α25 (OH2) D3 has no effect. Moreover, experiments conducted in the metastatic derivative of the SW480 cells, SW620, also have very low levels of VDR and did not respond to the addition of 1α25 (OH2) D3 25, 37.
It has been discussed that 1α25 (OH2) D3 can promote a differentiated phenotype in colon cancer cells by up-regulating e-cadherin 25. However, 1α25 (OH2) D3 could be aiding differentiation via other mechanisms. Recently, it has been found that 1α25 (OH2) D3 can induce the wnt antagonist DICKKOPF-1 (DKK-1) gene in colon cancer cells 38. The wnt/β-catenin pathway requires the presence of both the frizzled receptor and LDL receptor-related protein (LRP5/6); both receptors form a complex that accepts a wnt ligand and induces the wnt/β-catenin canonical pathway 39, 40. DKK-1 is a protein that can bind to the LRP 5/6 receptor and induce endocytosis; therefore, preventing the formation of the wnt-frizzled-LRP5/6 receptor complex, which decreases wnt/β-catenin canonical signaling 41, 42. It has been shown that DKK-1 transcription is increased by β-catenin/TCF-4, and should provide a negative feedback to wnt/β-catenin signaling; however, DKK-1 expression is low in colon cancer suggesting this feedback mechanism is disrupted 43. Moreover, it has been shown that key CpG island promoters of two wnt-inhibitors (DKK-1 and Wnt inhibitory factor-1 (WIF-1))are hypermethylated in colon cancer, which contribute to their decreased expression and lack of activity 44. Aguilera et al. has shown that 1α25 (OH2) D3 increases both DKK-1 mRNA and protein expression in SW480-ADH colon cancer cells. Moreover, researchers used immuno-deficient mice supplemented with EB1089 (vitamin D analog) and showed an increased expression of DKK-1 45. A less studied member of the DKK family is DKK-4. Interestingly, DKK-4 has contrasting effects compared to DKK-1. Franco et al. reported that DKK-4 was up-regulated in human colorectal tumors and had an inverse relationship with VDR expression. Moreover, it was demonstrated that DKK-4 was a down-stream target of TCF/β-catenin. However, in the presence of 1α25 (OH2) D3, DKK-4 expression was decreased 45. Therefore, it could be suggested that 1α25 (OH2) D3 can simultaneously hinder the wnt/β-catenin pathway and promote an epithelial phenotype by increasing the wnt antagonists (DKK-1) and decreasing the wnt agonist (DKK-4).
1α25 (OH2) D3 may also mediate its effects by interacting with transcription factors involved in epithelial cell function such as inhibitors of DNA-binding proteins (Id). Ids are important regulators of development, but if uncontrolled can promote tumorigenesis 46. Moreover, Ids have been found to contribute to colon carcinogenesis 47. Understanding the fact that 1α25 (OH2) D3 promotes colonic cellular differentiation, Fernandez-Garcia et al. proposed that 1α25 (OH2) D3 may alter Id expression in colon carcinoma cells 48. Using SW480 colon cancer cells, researchers demonstrated that treatment with 1α25 (OH2) D3 increased Id1 expression, which remained high in the differentiated phenotype. However, the presence of 1α25 (OH2) D3 decreased Id2 expression and promoted an anti-proliferative effect possibly by decreasing c-myc and the number of TCF/β-catenin complexes48. Interestingly, researchers also found that 1α25 (OH2) D3 blocked angiogenesis by decreasing such factors as vascular endothelial growth factor (VEGF)48. This area of research is very new and should be explored more in order to further characterize the roles of Id1 and Id2 in colon carcinogenesis. 1α25 (OH2) D3 may be promoting a normal epithelial phenotype in colon cancer cells through the above mechanisms; this is summarized in figure 1. However, many of these protective mechanisms are dependent on the presence of VDR, which is known to decrease as the progression of colon cancer advances. However, it is possible to explore reasons why VDR expression decreases in order to provide interventions so that treatment with 1α25 (OH2) D3 can be more effective.
As mentioned previously, most colon carcinomas express very low levels of VDR in the later stages of development; therefore, this makes treatment with 1α25 (OH2) D3 challenging. Little is known on how or why the VDR expression levels decrease in colon carcinogenesis. However, if the mechanism is discovered then treatment strategies can be targeted to increasing VDR expression in the later stages of colon carcinogenesis. One potential mechanism for the low VDR expression in colon cancer involves a transcription factor called SNAIL1. SNAIL1 has been correlated with low VDR expression in human colon cancers 49. SNAIL1 is a zinc-finger transcription factor that binds to the VDR gene promoter and represses activity and therefore decreases VDR mRNA expression levels 23, 49; this is summarized in figure 2a. SNAIL1 has been well characterized in tumor invasion and epithelial mesenchymal transition (EMT), and has also been shown to suppress e-cadherin gene expression 50, 51. In Larriba et al., severe immune-deficient female scid mice were injected with either 5×10^6 SNAIL1 or mock-infected SW480 cells and treated with either a placebo or EB1089 (vitamin D analog) 21. Also, they used SW480- ADH cells and 1α25 (OH2) D3 for numerous in vitro experiments 21. Collectively, for the in vitro studies, the authors discovered that SNAIL1 diminished the translocation of β-catenin from the nucleus that was induced by 1α25 (OH2) D3 in the SW480 cells; therefore, the expression of genes activated by β-catenin were increased. Also, the presence of SNAIL1 removed 1α25 (OH2) D3 inhibition on cell proliferation and decreased VDR protein expression. For the animal studies, Larriba et al. found that in the animals injected with the SNAIL1 SW480 cells, the nuclear exportation of β-catenin induced by EB1089 was significantly decreased compared to the mock-infected animals 21. In short, the above study concluded that SNAIL1 positively regulated the wnt/β-catenin pathway, decreased VDR expression, and potentially abolished the abilities of 1α25 (OH2) D3 to differentiate colonic cells.
It is well known that transcription factors work with other transcription factors in order to fine-tune the transcription of target genes. Therefore, it is of little surprise that researchers discovered that SNAIL1 was coordinating with other transcription factors in order to regulate VDR expression levels. One of these potential transcription factors is ZEB1. This unique transcription factor has the ability to down-regulate e-cadherin expression and stimulate VDR protein levels 52, 53. ZEB1 homodimerizes with ZEB2 and both are zinc-finger transcription factors that can bind to the VDR promoter region 54. ZEB1 has the ability to activate or repress transcription of key genes (e-cadherin, VDR), but this is dependent on the recruitment of co-activators or co-repressors, respectively. ZEB1 has an N-terminal region that can bind the co-activator, p300, an acetyltransferase which can alter chromatin structure so that it is in an open conformation 55, 56. On the other hand, in order for ZEB1/ZEB2 to repress transcription they need to recruit a co-repressor, CtBP 57, this is summarized in figure 2b. In the case of colon cancer, Pena et al. found an interesting relationship between SNAIL1, ZEB1, VDR, e-cadherin, P300, and CtBP 20. Using tumors collected from colon carcinoma patients, researchers measured mRNA levels of the above by using RT-PCR. Results showed that when SNAIL1 was over expressed, e-cadherin and VDR expression levels were decreased. However, both ZEB1 and e-cadherin expression levels correlated with elevated VDR levels, but if the co-repressor, CtBP, was expressed, then ZEB1 and e-cadherin had an inverse relationship. Moreover, high levels of p300 promoted a stronger correlation between ZEB1 and VDR expression; it could be proposed that designing p300 analogs in order to promote this relationship over the ZEB1-CtBP relationship might be beneficial 20. Overall, this study suggests that activities of SNAIL1 and ZEB1 are tightly regulated and dependent on the presence of co-activators or co-repressors.
Researchers later discovered a potential role for SNAIL2 in the suppression of VDR in colon cancer. SNAIL2, also known as SLUG, like SNAIL1, is a zinc-finger transcription factor that contributes to EMT 58. SNAIL2 decreases e-cadherin gene expression and other epithelial genes and is associated with a poor prognosis 59, this is summarized in figure 2c. Approximately, 60–70% of human colon tumors express SNAIL1 mRNA and have a low VDR expression 22, 49. However, VDR expression is low in approximately 80–90% of colon cancers; therefore, it could be suggested that another transcription factor could contribute to the down regulation of VDR in colon cancer. Therefore, Larriba et al. proposed that SNAIL2 represses VDR promoter activity and consequently decreases VDR mRNA and protein expression 22. Using SW480-ADH cells, it was found that SNAIL 2 decreased VDR activity and when present with SNAIL1 had an additive effect of the inhibition of VDR promoter activity. Like SNAIL1, SNAIL 2 blocked the effects of 1α25 (OH2) D3 on increased e-cadherin expression and exportation of β-catenin from the nucleus. Using colon tumors collected from humans, Larriba et al. found that SNAIL2 was up-regulated in 58% of the tumors 22. Furthermore, if both SNAIL1 and SNAIL2 were present, then VDR expression was significantly lower compared to a tumor expressing only one of the above transcription factors 22. Since SNAIL1 and SNAIL2 are present in the later stages of carcinogenesis, when malignant transformation is prevalent and VDR expression is low, they can contribute to the constitutive activation of the wnt/β-catenin pathway and can be potential targets for treatment.
As discussed thus far, 1α25 (OH2) D3 has the ability to promote differentiation in colon carcinoma cells; however, this is only possible if VDR expression is sufficient. Previously, we have discussed possible genomic explanations on why VDR expression might be down regulated in colon cancer, but it is possible that low VDR expression levels might be explained by epigenetics.
Recently, epigenetics and cancer have become a popular field of study. Epigenetics is the study of changes in gene expression caused by mechanisms unrelated to changes in the DNA sequence60. Unlike genetics, epigenetics is highly influenced by diet and lifestyle. Since carcinogenesis has become a topic of interest, many researchers are considering epigenetics as a potential contributor to cancer incidence and its progression. Colon cancer is one of the few cancers that has a well established relationship between specific genetic mutations and specific carcinogenic events 61. Slattery et al. has linked colon tumor mutations and epigenetic alterations that are associated with some of the key genetic polymorphisms that occur in colon carcinoma 24. Slattery's results show that Fok1 VDR polymorphisms were associated with CIMP positive (CpG island methylator phenotype) and Ki-ras mutated colorectal tumors. However, the VDR polyA polymorphism was associated with a lower risk of developing Ki-ras mutations 24. In short, this study showed that the progression of colorectal cancer was dependent upon polymorphisms of VDR. However, other researchers believe that the VDR may not be mutated, but simply dys-functional.
Recently, it has been suggested that the relationship between 1α25 (OH2) D3 and VDR is possibly skewed in colon carcinogenesis due to the presence of histone deacetyltransferases (HDACs). HDACS are extremely active in carcinogenesis 62. Methylation often recruits other co-repressors such as HDACs in order to silence key regulatory genes such as tumor suppressors. HDAC's alter nucleosome structure by removing acetyl groups from the n-terminal of the tails of histone octamers. By removing the acetyl groups, the nucleosome structure alters to a tight conformation and transcription is hindered 63. SNAIL1 often acts as a repressing transcription factor and is highly activated during EMT; at which time HDAC activity also increases 64. In colon cancer, it has been found that HDACs 1,2, and 3 have an increased expression, but the mechanism(s) behind this phenomenon are unknown. Godman et al. used SW480 and HCT116 cells (another human colon carcinoma cell line) and RNAi in order to determine the relationship between HDAC3 and vitamin D signaling. Results showed that knockdown of HDAC3, decreased β-catenin translocation to the nucleus, increased expression of key wnt inhibitors (TLE1 and TLE4), and increased expression of VDR in SW480 and HCT116 cells. Cells with HDAC3 shRNA were also more sensitive to the actions of 1α25 (OH2) D3 on cell cycle inhibition 25. A similar study was conducted using Caco2 cells (an immortalized line of human colorectal adenocarcinoma cells). The researchers treated cells with butyrate compounds (short-chain fatty acids produced by the colon during fermentation by intestinal bacteria that can acts as HDAC inhibitors) and found that VDR expression was increased 65. Therefore, HDAC inhibitors are another potential mechanism in which scientists can alter VDR expression in colon carcinogenesis in order to create a more effective treatment regime.
By understanding the mechanisms behind the decreased VDR expression observed in colon cancer, we can target these mechanisms and potentially restore VDR expression. Therefore, a likely future direction for this area is to create a treatment regime that includes both VDR ligands (1α25 (OH2) D3) and HDAC inhibitors.
The best treatment for cancer is prevention. Many epidemiological studies have shown that high levels of serum 25-hydroxyvitamind D (25(OH)D3) are related to lower incidence rates in many cancers, particularly colon cancer 66–68. 25(OH)D3 is a metabolite in the vitamin D pathway that precedes the 1α hydroxylase in the kidneys in order to form 1α25 (OH2) D3. The vitamin D pathway includes both endogenous and exogenous sources of vitamin D. In other words, vitamin D3 from either exogenous or endogenous sources will both cause a significant increase in serum 25(OH)D3. According to a study using data from NHANES 2000–2004, up to 78% of Americans have a serum levels less than 30ng/ml of 25(OH)D3 69. Moreover, it has been shown that individuals who have 25(OH)D3 serum levels greater than 30ng/ml, which is considered an adequate amount of 25(OH)D3, have a 25% reduced risk from dying of colorectal cancer 27. Moreover, Gorham et al. demonstrated that there is a dose response relationship between serum 25(OH)D3 and the odds ratio of colon cancer. In short, his work illustrates that when 25(OH)D3 serum levels reach 38ng/ml there is a 55% reduction in colon cancer risk 70. Freedman et al. further proved the dose response relationship, by showing that individuals with 25(OH)D3 serum levels between 50–80ng/ml and greater than 80ng/ml had a relative risk of colon cancer mortality of 0.44 and 0.28, respectively 71. Currently, the recommended dietary allowance (RDA) for vitamin D3 is 600 IU/day and the upper limit tolerance is 4000 IU/day. It has been estimated that if Americans increase their intake of vitamin D3 to 2000IU/day, then this would lead to a 27% decrease in colorectal cancer incidence 72. An intake of 2000 IU/day would lead to approximately 40–60ng/ml 25(OH)D3 serum concentration levels, which can act has a protective factor against both the incidence and mortality of colorectal cancer 73. Furthermore, it has been proposed that raising the RDA to 2000 IU/day would prevent approximately 49,000 colon cancers per year for North America and Canada 71. Again, vitamin D3 intake can be obtained through dietary sources, sun exposure, or dietary supplements.
One of the major vitamin D dietary sources for Americans is milk. One cup of milk contains approximately 50 IU of vitamin D3, and the average American consumes about 1¼c of milk/day, with adults consuming less 74. Studies have shown conflicting results between milk consumption and colorectal cancer. However, Cho et al conducted a meta-analysis of ten cohort studies from five different countries and found that individuals who consumed more than one cup of milk per day had a 15% reduced risk of developing colorectal cancer. Moreover, he showed that for every 500g/day increase in milk consumption (2c of milk); colon cancer risk decreased by 12% 75. Since most Americans will only receive a small amount of vitamin D3 from dietary sources, the more logical source for vitamin D3 is through sun exposure. Spending approximately thirty minutes outside at noon will produce approximately 10,000 IU of vitamin D3 27. However, this can vary from person, place, and time of day. Dietary supplements are another alternative for those individuals who live in the very Northern hemisphere or are concerned about skin cancer risk, since sun block does block the synthesis of vitamin D3 in the skin.
In this review, it has been demonstrated that vitamin D and its metabolites have a potent effect on colorectal cancer, this is summarized in figure 3. The components of the vitamin D pathway can be used both as treatment and preventive strategies for colorectal cancer. The metabolite 1α25 (OH2) D3 targets the wnt/β-catenin by up regulating key tumor suppressor genes such as e-cadherin, which promotes an epithelial phenotype, but is only useful when the VDR is present. In colorectal cancers with low VDR expression, treatments could target the genomic and epigenomic level alterations to increase VDR expression by modulating transcription factors such as SNAIL1 or utilizing HDAC inhibitors, respectively. Finally, epidemiological studies suggest that the current RDA should be raised to 2000IU in order to raise serum 25(OH)D3 levels above 30ng/ml, this increase in vitamin D status can most efficiently be obtained from sun exposure or vitamin D supplements. In summary, vitamin D3 and its metabolites appear promising for developing treatment and preventive strategies for colon cancer.
This work was supported by American Cancer Society grant ACS RSG CNE-113703 and by grants from the National Institutes of Health: National Cancer Society grant NCI 1K22CA127519-01A1 and National Institute of Environmental Health Sciences Center grants ES09145 and ES007784
Disclosure Statement: The authors have nothing to disclose
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Willie Wright is like a lot of recruits right now: he's waiting to see what happens next.
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Restaurants attempting to make their hamburgers stand out continue to search for new things to put on top of them.
House-made sauces, unusual lettuces and signature cheese combinations have all found their way atop America's favorite sandwich, but a number of restaurants have started topping the meat with more meat.
Besides bacon, a common addition, pastrami, pulled pork and brisket are being piled on burgers.
Michael LaScola, chef of American Seasons restaurant in
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text: Posted January 3, 2014 · Report post I thought this was an option before, but now I can't see the option to add a new product to the Reviews section. I want to review inositol as a supplement, but the only thing that comes up is the Swansons brand which I haven't used. As a suggestion, for vitamins and supplements, I think it would be more effective to group together all the brand reviews under one name (e.g. no separate listing by brand name, just the vitamin name), then have a section in the actual review for the specific brand name to keep things more straightforward. Most vitamins/ supplements are listed like this, but some are listed by brand name as well, which makes things more complicated (e.g. 2 listings for vitex, one for Nature's Way and another one for vitex in general). Current regimen: garlic supplements & turmeric [as needed, for antioxidants, both are AMAZING for skin], Enzymedica gluten blocker/ digestive enzymes [as needed], nicadan [the only vitamin presciption I take -1/2 per day works well], DIM (needed), inositol (very rarely nowadays - no longer needed as my PCOS is balanced). Also trying herbs for adrenal fatigue. I try to simplify as much as I can. Don't take more supplements than you need....try one at a time and be patient. The supplements that really helped me when my acne was at its worst: inositol, DIM [not as frequently now!] digestive enzymes [don't need them every day anymore, only on cheat days], herpanacine & vitamin C with rose hips/ low acid [not every day], regular sun exposure for vitamin D3, superoxide dismutase (SOD) enzyme supplements. NOTE: I do not recommend DIM for long term use, and I do not recommend hormonal creams without doctor supervision. Lifestyle & Skin Care: acupuncture, regular exercise/ yoga, low histamine diet, avoiding unnecessary stress, balancing skin's PH (using BioClin and other products), using distilled/ filtered water to wash face, occasional high frequency & lactic acid peel facials... Grocery list: ** Find the cause, find the cure ** ** If you have a question for me, please ask it publicly so that others can benefit from the discussion** Share this post Link to post Share on other sites


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Does Anyone Remember Little DAX....?
Does anyone remember little Dax? The little boy who had cancer and his family and town decorated early for Christmas so he could celebrate one last time? This happened a couple years ago. Well a Christian singer,Matthew West,was sent the story of Dax, and wrote a song and that song and Dax's story were made into a movie...The Heart of Christmas. The movie is going to be on GMC(The Gospel Music Channel) tonight at 9pm. It really is an amazing story and there are many moms on here that I am hoping will remember. If you do and know the links to some of the posts from back then,please add them.
Thanks dzyre,for the link to the original post(or one of them)
The first time I heard Mathew West's song I just kinew it had to be about Dax...and yes,I cry everytime I hear it. I still remember the video of his Momma singing and dancing with him.


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More of the big Oscar contenders are finally making their way into theaters so our Oscar Power Rankings have already started to shift. "Lincoln" jumps four spots in the biggest move, "Moonrise Kingdom" has made a move as well and "Flight" has come out of almost nowhere to make the top 10.
The rankings will be updated every two weeks through Thanksgiving and every week after Thanksgiving until the nominations are announced on Jan. 10. So continue to check back.
1) "Argo"
In theaters
Great reviews, very good box office for an R-rated adult drama and strong word-of-mouth have all but assured Ben Affleck's film a nomination for best picture.
Last ranking: 1
2) "Life of Pi"
Opens Nov. 21
It got the big response at the New York Film Festival and subsequent screenings that it needed. Everyone who has seen the Ang Lee film loves the visuals and the way he brought a seemingly unfilmable novel to the screen.
Last ranking: 5
3) "Les Miserables"
Opens Dec. 25
The biggest question for the film version of the stage musical may be: Will opening in late December hurt its chances?
Last ranking: 2
4) "Lincoln"
Opens Nov. 9
Daniel Day Lewis' performance as ol' Abe is so mesmerizing that it be enough by itself to make the Steven Spielberg flick a real contender. And remember, Academy voters tend to skew older so a smart historical drama can be catnip for them.
Last ranking: 8
5) "Silver Linings Playbook"
Opens Nov. 21
David O. Russell's comedy-drama has some steam. Now, it just needs to get into theaters.
Last ranking: 4
6) "Moonrise Kingdom"
Out on DVD next week
This wonderful Wes Anderson fable seems to have at least temporarily passed "Beasts of the Southern Wild" as the small indie film of choice. That it was a surprise hit at the box office and has recognizable names like Bruce Willis and Bill Murray in the cast helps.
Last ranking: 9
7) "The Sessions"
In theaters
It's a tough sell (a paralyzed writer loses his virginity to a sexual surrogate) but it's got great performances from Helen Hunt and John Hawkes and the reviews and word-of-mouth are very strong.
Last ranking: 7
8) "Beasts of the Southern Wild"
DVD release date not yet set
Now that the best picture nominees have been increased to 10, the Academy voters almost always find room for a small, indie film (see "Winter's Bone") and this extraordinary and critically-acclaimed summer movie set in the Louisiana delta should fit the bill. Expect a lot of attention in the pre-Oscar awards which would further boost its chances.
Last ranking: 6
9) "The Master"
In theaters
Rapidly falling out of the Oscar conversation, because of almost nonexistent box office and reporters of walkouts by those who have paid money to see the film. Joaquin Phoenix's recent dissing of the Oscars won't help with Academy voters.
Last ranking: 3
10) "Flight"
Opens Nov. 2
The Denzel Washington film has come on unexpectedly strong, thanks to big response out of New York Film Festival screenings and a trailer that is a real grabber. At a minimum, Washington looks a good bet for a best actor nod but the film movie could do better than that.
Last ranking: —
On the bubble
"Django Unchained"
Opens Dec. 25
The Quentin Tarantino potboiler has the same big problem as "Les Miserables" — a very late opening — and it lacks the immediate appeal of "Les Miz."
Last ranking: 10
"Zero Dark Thirty"
Opens Dec. 19
The new trailer has finally gotten the buzz going for Kathryn Bigelow's first film since she won the Oscar for "Hurt Locker."
Last ranking: —
"Cloud Atlas"
In theaters
How this three-hour this adaptation of David Mitchell's mind-bending novel does on its opening weekend may determine its Oscar fate, at least for best picture.
Last ranking: On the bubble
"The Impossible"
Opens Dec. 21
Set during and after the 2004 Thailand tsunami, the movie has some buzz but it won't get into theaters in most of the country until January. Screenings for voters may come even later than "Django" and "Les Miz."
Last ranking: On the bubble
"Anna Karenina"
Opens Nov. 9
Everyone who's seen it loves the look and the lead performances by Keira Knightley and Jude Law but that may not be enough.
Last ranking: On the bubble
Keep an eye on
"Promised Land"
Opens Dec. 28
Just now starting to get some commentary in the Oscar discussion. The first trailer for this Gus Van Sant drama, starring Matt Damon and set in the American heartland, might have enough appeal to make a late run.
Last ranking: —
Opens Nov. 23
Now that the HBO take on Alfred Hitchcock has aired, Sacha Gervasi's film about the making of "Psycho" is starting to get some Oscar attention. It doesn't hurt when you have Anthony Hopkins as Hitch, Helen Mirren as his wife Alma Reville and Scarlett Johansson as Janet Leigh. And the trailer is fun.
Last ranking: —
Slip sliding away
"The Dark Knight Rises"
Out of DVD on Dec. 4
Christopher Nolan film has all but dropped out of the Oscar talk in recent weeks.
Last ranking: On the bubble
For all things Oscar and more, follow Charlie McCollum at Twitter.com/charlie_mccollu.


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Plastic roller for old sliding windows
A professional from Stamford, CT says:
July 2, 2015
I am enclosing some pictures of the plastic roller assembly of some old sliding windows. Any way you can locate these for us ?
Tom from SWISCO responded:
July 2, 2015
Thanks for contacting us. We have found a possible replacement for this roller and hope to have it available soon. I will let you know when we do!
Donna from SWISCO responded:
July 10, 2015
Please see new SWISCO product code 87-135, roller assembly.


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Clinton welcomed North Brunswick to Dark Horse Stadium on Friday night for the first round of the NCHSAA 2-AA football playoffs. The Dark Horses were looking to recover from last week's loss to rival Wallace-Rose Hill and the Scorpions proved to be just what the doctor ordered. Clinton scored on their first two possessions, of the penalty marred contest and quickly put any upset hopes North Brunswick may have had on ice, running away from the Scorpions in a 49-18 rout.
Clinton took the opening kickoff, advancing the ball to the 50-yard line and setting up the offense with great field position to start the game. Four plays later Rayquan Faison took the ball into the end zone from four yards for the first score of the night less than one minute into the game. Chandler Perry added the PAT kick giving Clinton the 7-0 lead at the 11:03 mark of the first quarter.
Clinton's defense quickly put the ball back in the hands of the offense when they forced the Scorpions to punt on their first possession. The Dark Horses took over deep in their own territory at the 14-yard line and proceeded to drive the ball for their second score of the night. Tyion Wright got the honors, finishing up the drive with a 4-yard touchdown run to give the Horses a two score lead at 14-0 after Perry's successful PAT kick with 4:32 left in the first quarter.
North Brunswick would quickly answer Clinton's second score with a 32-yard touchdown strike at the 3:03 mark of the first quarter. The Scorpions extra point kick was no good but North Brunswick had cut the Dark Horse lead to 14-6 with 3:03 remaining in the opening frame.
The Dark Horses returned the ensuing kick out to their own 25-yard line where they embarked on a time consuming 75-yard drive for their third touchdown of the night. Ryheem Skinner carried the ball in for the final two yards of the drive, scoring at the 7:07 mark of the second quarter. After Chandler Perry added the PAT kick Clinton had extended the lead to 21-6.
The Dark Horse defense forced another Scorpions punt, putting the offense in business again. Clinton's drive was cut short by a fumble that was recovered by North Brunswick at the Dark Horse 42-yard line. The Dark Horses turned the Scorpions over on downs to get the ball back with less than two minutes remaining in the first half.
Clinton moved the ball quickly into the red zone, utilizing their timeouts and getting the ball out of bounds on a couple of plays to stop the clock. Tyion Wright scored for the second time with a five yard plunge and Chandler Perry added the PAT kick to put Clinton on top 28-6 with 23 seconds left. The Scorpions were unable to move the ball on their final possession of the first half and the teams headed to the half time break with the Dark Horses in command of the game.
North Brunswick's Jayhlen Washington took the opening kick off of the second half and snaked his way up the sideline, breaking numerous tackles on his way to the end zone with the second Scorpion score of the game. The two point try failed but the exciting kickoff return drew the Scorpions closer at 28-12 just 18 seconds into the second half.
Clinton's offense went back to work, driving the ball 68 yards on their first possession of the second half. Rayquan Faison punched the ball in from 7 yards out to move the lead to 35-12 after Perry's PAT kick. On the Scorpions next possession they drove the ball deep into Clinton territory where Derek Bryant came up big for the Dark Horses when he intercepted a pass at the Clinton 18-yard line. The Dark Horses were forced to punt for the first time after the offense was unable to move the ball. The Scorpion's punt returner mishandled the kick and Gage Jackson pounced on the loose ball to give the Dark Horse offense new life at the Scorpion 30-yard line.
Clinton quickly took advantage of the turnover, driving the ball inside the two yard line where Rayquan Faison took over and roared in for his third score of the night to push the Dark Horse lead to 42-12 with Perry's PAT kick at the 5:51 mark of the third quarter.
Clinton's Tyion Wright stymied the next North Brunswick threat when he intercepted a Scorpion pass in the Dark Horse end zone for the third turnover of the game. The Dark Horse offense took over on their own 20-yard line and seemed content to eat the clock with a grinding drive that resulted in the final score of the night. Rayquan Faison roared into the Scorpion's end zone with his fourth score of the game, a 1-yarder at the 11:03 mark of the fourth quarter. Chandler Perry added his seventh PAT kick of the game to put the Horses on top 49-12.
North Brunswick would add another score when they recovered a Clinton fumble in the end zone with three minutes remaining in the game. The extra point try sailed wide left, leaving the score 49-18. The Dark Horses cleared the bench as the remaining clock expired on the first round game.
The Dark Horse offense racked up 519 total yards against the Scorpion's defense. Rayquan Faison led the way with 109 yards on 18 carries and 4 touchdowns. Ryheem Skinner carried the ball 17 times for 176 yards and 1 touchdown, Tyion Wright added 141 yards on 14 carries and two touchdowns. Kris Williams called his own number 3 times for 23 rushing yards. Williams passed three times, completing all three attempts for 38 yards through the air. Ryheem Skinnner had two catches for 29 yards and Jeremiah Pope caught 1 ball for 9 yards.
Defensively the Dark Horses were led by Prentice Murphy's 9 tackles. Rayquan Faison, Devonte Smith and Jonathan Wright each had 6 tackles and Derek Bryant and Tyion Wright each intercepted a pass. Gage Jackson recovered a muffed punt in the second half, flipping the field for the Dark Horses and setting up a Clinton score.
After the game, Clinton head coach Bob Lewis was happy with the first round win, saying "our offense played really well tonight, our line blocked better and we racked up some big yardage. The defense played well too, Tyion Wright and Derek Bryant came up with big interceptions for us. We gave up 18 points but really only one of the touchdowns was against the defense. They got a kick off return for a touchdown and recovered the fumble late for another score. This was a good solid first round win and we are moving on."
The win improves the Dark Horses' record to 9-2 on the season and sets up a second round match-up with Wilson Beddingfield next Friday night. The Dark Horses will be at home once again for the second round with kickoff scheduled for 7:30 pm.


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- Home >
- Abrasives, Cleaners & Finishing >
- Oil Finishes >
- Osmo UV Protection Oil
Exterior timbers turn grey or silver over time as a result of exposure to the sun and rain. Osmo UV 420 is a high quality oil that protects against the greying effect of the sun's UV rays on exterior wood by a factor of 12. It can be applied with a brush or mohair roller to a wide range of exterior soft and hard woods including pine, larch, teak, oak and bamboo. It offers superb durability against weathering with an added biocide to combat insect attack and fungal growth. Easily applied, Osmo UV Protection Oil 420 dries to a satin-matt finish that will not peel, flake or blister. Available in 750ml and 2.5L sizes.
|Application Method
|Brush \ Roller
|Clean Up
|White Spirit
|24 m² per litre
|Drying Time
|8-10 hrs
Overall rating 4 reviews3.2 out of 5 based on
Jools B
5 October 2017
Ok on uprights, not good on cills & horizontal beadsUsed on European oak windows. Looks great initially but after 4 or 5 months it hadn't lasted on the cills & horizontal beads. Really disappointing as we'd changed from another product to Osmo thinking it was better. Won't be using it again.
20 December 2015
Good product for external hardwoodThis product works well for hardwood that is outside, though as the product documentation says it is intended for vertical surfaces. So I would not be too surprised to see it do badly on window sills, as commented by another reviewer. At test board in a SW facing situation has after one summer weathered much better than another board (from the same piece of wood) that was treated with tung oil. 12 hours to dry would be a touch optimistic in the British climate, but other than that it is as the manufacturer describes. The natural version does leave the wood looking much more natural than tung oil. Not yet seen any sign of flaking or blistering.
Rob Bailey
20 April 2015
Goes on easily, dried quickly, looks goodUsed on exterior hard wood on boat. It was easy to use and gives a good finish.
Red barn man
16 January 2015
Disappointing performance given the priceHave used this on new oak windows - 2 coats. The finish is initially good and it has performed reasonably well on vertical surfaces but the sill and beads where water sheds less quickly have started degrading after just 6 months allowing the wood undermeath to turn black. Drying time is rarely as short as 12 hours, in cold weather it can take a couple of days. (I have also used the non-UV version and that dries more quickly). Will try again in the late spring and put on 3 or 4 coats to see if this holds up better.


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Les Aristos Trailer (2006)
20 September 2006 Comedy 79 mins
The Arbac de Neuvilles are one of the oldest families in France. They have inhabited their ancient château for fifty-two generations and are proud of their noble ancestry. But today they are stone broke. When a bailiff turns up notifying them that they owe two million euros in back taxes, these proud aristocrats are understandably shaken to the core of their ancestral seat. Just how are they to find this amount of money when none of them has any capacity for work?
Watch the official Les Aristos 2006 trailer in HD below or find more Les Aristos videos on Vidimovie.


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Black Friday is just around the corner! Make the most out of your shopping trip by checking our opening hours so that you know what stores to hit first. From the latest fashions and electronics to must-have gifts and everything in between—there's a deal to be had around every corner.
Lower Level Sears Court
Now – Mon, Dec 11
Bring your pet to get a 'paw-fect' picture with Santa!View Details


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Sailing on vacation is one of my passions and choosing SweetDreamers was the best decision! I... read more
Sailing on vacation is one of my passions and choosing SweetDreamers was the best decision! I... read more
I got great response over my queries from delphine about the boats, however i had to book the boat... read more
About SweetDreamers Charters - Private Day Trips
1 - 10 of 202 reviews
Sailing on vacation is one of my passions and choosing SweetDreamers was the best decision! I booked the 34 Catathai Catamaran with double trampoline for 9 friends. All the amenities provided+ lunch and drinks is well worth the cost for a private day trip. If...More
SweetDreamers Team would like to thank you for the review and we are happy that you enjoyed your cruise :-)
I got great response over my queries from delphine about the boats, however i had to book the boat with their local office in phuket ( not their fault , my reasons ). Even then their local office experience was good and booking process was...More
Dear Sameer, We are happy to hear, that you spend a nice day with catamaran Nina. We would like to thank you for your nice review and wish you a great start into New Year 2017. Best wishes, SweetDreamers Team :-)
We booked a day trip from Ao Po Marina (Phuket) to Phang nga bay. A transfer was arranged for us from/back to the hotel and we were greeted by the boat owners at the Marina as soon as we arrived, The whole booking process and...More
Dear Maira, Thank you very much for your feedback and nice words on TripAdvisor. We are happy to hear that you liked our service and the cruise. We hope to assist you again in the future and wish you nice Christmas and Happy New Year....More
Delphine who helped with my booking was great at answering all my questions and managing my last minute changes on the boat. She is the best. Had an excellent sunny day out on the boat despite the rain in the morning. The crew on boat...More
Dear Leona, It was us a pleasure to assist you to organise a cruise in Phuket and thank you very much for your lovely review. Best wishes, Delphine
We chartered the Catathai for 3 days + 2 nights at the beginning of September. From the very beginning, we were impressed with Delphine's responsiveness & thoroughness! Once on the Catathai, we were welcomed with great hospitality by Alex (Catathai captain) & Kong (Thai captain)....More
Dear Katelyn, Thank you very much for your feedback. We are happy that you liked our service, boat and the crew and hope to assist you again in the future. Best wishes, SweetDreamers Team
We went out for 5 days charter in June 2016. The booking procedure with Delphine was just a pleasure. She respond very fast and provided us with a lot of information for our charter. Everything was just as promissed: We were picked up early morning...More
Dear Mark, We are happy to hear that you enjoyed the cruise and the food on board. We hope to assist you again for your next sailing holiday in Thailand. Best wishes, SweetDreamers Team
We were 2 families of 7 people all together (kids aged 6 and 8 years). The trip was a perfect getaway for 3 nights in Phuket. The catamaran was spacious, fully equipped with everything we needed, and in excellent condition. The crew aboard were very...More
Dear Victoria, We are happy to hear that you got a beautiful time with your friends and family. Thank you for sharing your experience with us and hope to assist you again in the future. Best wishes, Delphine
The booking process with Delphine was very easy and clear. She answered our e-mails very quickly and clarified all our doubts before our trip. We got a private speedboat and went to Phang Nga on the first day, and Phi Phi on the second day....More
Family of 4 took a 3 day charter on catamaran Amadeus in May this year. From the time of booking to the actual trip everything was handled professionally. This was our second time out using Sweetdreamers and we couldn't have been happier. The catamaran was...More
Dear Joanne, Thank you and your family for being great customer and we will be happy to assist you again in the future. Have a good time back home, Delphine
Thank you Delphine for a great customer service and a well organized charter. We will be back again and book with you another charter for sure. Highly recommend this charter company for everyone who is looking for a yacht in Phuket.


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- Home
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- Get Involved
JEAN, TEXAS. Jean, at the intersection of State Highway 114 and Farm Road 1769, in north central Young County, was settled in 1875 by rancher S. B. Lamar, who built a schoolhouse and a store there. His son, James Lamar, became the first postmaster and named the settlement after his sweetheart. Jean was moved one mile to the Gulf, Texas and Western Railroad when the line was built through the area in 1903. R. F. Willis donated land for the new townsite and gave the Trinity Townsite Company alternate blocks. G. G. Cantrill built a store that was also used for the railroad station. By 1940 Jean had 300 inhabitants and five stores. In 1980 and 1990 the population was estimated as ninety-one. The population grew to 110 in 2000.
BIBLIOGRAPHY:Carrie J. Crouch, Young County: History and Biography (Dallas: Dealey and Love, 1937; rev. ed., A History of Young County, Texas, Austin: Texas State Historical Association, 1956).
Image Use Disclaimer
All copyrighted materials included within the Handbook of Texas Online are in accordance with Title 17 U.S.C. Section 107 related to Copyright and "Fair Use" for Non-Profit educational institutions, which permits the Texas State Historical Association (TSHA), to utilize copyrighted materials to further scholarship, education, and inform the public. The TSHA makes every effort to conform to the principles of fair use and to comply with copyright law.
For more information go to: http://www.law.cornell.edu/uscode/17/107.shtml
If you wish to use copyrighted material from this site for purposes of your own that go beyond fair use, you must obtain permission from the copyright owner.
The following, adapted from the Chicago Manual of Style, 15th edition, is the preferred citation for this article.Handbook of Texas Online, William R. Hunt, "Jean, TX," accessed November 25, 2017, http://www.tshaonline.org/handbook/online/articles/hnj05.
Uploaded on June 15, 2010. Published by the Texas State Historical Association.
For more information about towns and counties including physical features, statistics, weather, maps and much more, visit the Town Database on TexasAlmanac.com!


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Reviewed By Dave V (Highland, IN) Reviewed for a 2003 Hummer H2 —6/17/2015 6:45 AM
The install was very easy parts fit well Passed emission no problem
Reviewed By Charlene J (Faribault, MN) Reviewed for a 1985 Oldsmobile 88 —8/25/2017 8:41 PM
I purchased a Flowmaster cat converter to stop a check engine light from coming on. I also wanted some extra exht noise even though I only have a 231 V6. Mission accomplished on both.


text:
Buy a print or image licence
You can purchase this reproduction from National Trust, Hidcote Manor
If you have any products in your basket we recommend that you complete your purchase from Art UK before you leave our site to avoid losing your purchases.
Add or edit a note on this artwork that only you can see. You can find notes again by going to the 'Notes' section of your account.
oil mural transferred to canvas
156.5 x 115 cm
Accession number
Acquisition method
gift, 1980
National Trust, Hidcote Manor
Hidcote Bartrim, near Chipping Campden, Gloucestershire GL55 6LR EnglandView venue
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text:
Because He's Holding a Thermal Detonator!
When Princess Leia, dressed as Boushh, approaches Jabba the Hutt, her weapon of choice is the thermal detonator. According to Wookieepedia, the thermal detonator is a highly unstable grenade-like weapon popular among military personnel, criminals, bounty hunters, and mercenaries. It's good for one detonation and blasts up to 20 meters.
This thing turns out to be really important. Leia brings Chewbacca to Jabba the Hutt to claim the bounty of 25 thousand. Leia demands 50. Jabba asks why. Then C-3pO says:
Because he's holding a thermal detonator!
Everyone flips out, but Jabba laughs, and settles on 35 thousand.
Therefore, just by having the thermal detonator, Leia makes an extra 15 thousand. Not bad. I'll need to try that when negotiating bounties on wookiees, or my salary. And you know that Stewie Griffin will eventually use one on Family Guy.
Anyway, let's look more at the thermal detonator.
Here is the video from Return of the Jedi:
There is a Facebook group called "Because He's Holding a Thermal Detonator!" And for those of you who don't like Facebook groups, there's also a Facebook PAGE called "BECAUSE HE'S HOLDING A THERMAL DETORNATOR!!!" (note the misspelling)
Here is a song called Thermal detonator by the band Demolition. I never heard of it, either.
Now, let's go shopping for a thermal detonator.
Master Replicas Thermal Detonator
(Note: These are really hard to find because they're sold out, so winning one on eBay will likely be expensive).
Now, I know we all prefer Leia dressed as a slave, but here are some items of her dressed as Boushh, which I'm sure has a cult following just like every nuance of Star Wars.
Princess Leia Boushh 12 Inch Action Figure from Star Wars
Her helmet is removable, and yes, she's holding a thermal detonator.
The Leia as Boushh 12 inch Figure features:
- Fully articulated female body with 30+ points of articulation
- Authentic likeness of Carrie Fisher as Princess Leia Organa
- Jacket, Undershirt, Pants, Waistband, Belt
- Traditional Ubese Boots
- Ogygian Cloak
- Bandolier
- Impact Armor Mantle with canister pack
- Boushh helmet – interchangeable with Leia portrait
- Thermal Detonator
- Electrostaff
- Gloved hands with spike detail
- 12-Inch Figure Display Base with Star Wars logo
There are many other action figures of Leia as Boushh on Amazon.


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Published: September 8, 2008
FAMILY VALUES: The Flament family, from left, Alyssa, 9 months; Sarah; and Logan, 4, display a bin of recyclables outside their home in Poland. The family is taking a more environmentally friendly approach to daily living.
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Eight NBA players of past (mostly) and present (only one) that have played for at least 10 NBA Franchises, more than anyone else in league history. More →
As October comes to an end, it's not just about Halloween for us – it's also about beautiful women in minimal clothing, but still keeping it sorta family friendly. So … More →


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How nice if that was true all the time!!!
Unfortunately, reality isn't so fun...
PP2 Class Test was quite horribly timed and horribly done. I can only blame it on CNY and my laziness. Immediately after the test, we started our preparations for our PP2 tutorial presentation. Fortunately we got quite good remarks from the lecturer for our ~work.
Week 14 is a week with only 1 day of "class". I was assigned to Hospital Tuanku Ja'afar, Seremban for the PP2 hospital placement.
I met up with fellow batchmates in front of IMU at 7am and travelled to IMU Clinical School in Seremban. The journey took ~45minutes *we were very early*.
|The clinical school has a bridge leading to the hospital.
|General ward (picture taken online)
- Handwritten notes by physicians were difficult to comprehend as expected.
- Tonnes of abbreviations used not known even by lecturer.
- Pure bad luck :(
Study Break has officially begun...


text:
Highlife – October/November 2013 [DOWNLOADABLE PDF]
Bowral NSW 2576
PO Box 1174, Bowral NSW 2576
Ph: (02) 4861 6311
Fax: (02) 4861 6929
Highlife Magazine Southern Highlands
18 hours ago
Every five years Frensham hosts the Iris Country Fair and tomorrow's the big day. Billed as a true country fair, it will include rides, food stalls, a trash and treasure area, plants and garden art, and a marketplace with 50-plus stallholders. The fair runs from 9am to 4pm and entry is free. www.frensham.nsw.edu.au/iris-country-fair ... See MoreSee Less
2 days ago
It's formal season, and Bowral High School's Year 12 students celebrated at Centennial Vineyards on Monday night. Photos from the night will be in our Feb/Mar issue as our Dec/Jan issue is already at the printers. ... See MoreSee Less


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UPDATE: £650,000 initial fee set for ex-QPR loanee, Leon Best.
BBC - Tribunal sets fee for Best move
Coventry City have been ordered to pay Southampton an initial fee of £650,000 for striker Leon Best by a tribunal...The figure was set by the Professional Game Compensation Committee.
Notts County will receive a proportion of the fee, as part of the sell-on clause agreed when Best left Meadow Lane as a 17-year-old in July 2004.
Saints may also receive further payments based on appearances, and a further sum if Coventry win promotion to the Premier League during Best's initial contract which runs until 2010.
The south coast club will also receive a sell-on fee of 20% of any surplus above the figure of £650,000 if he moves on from the Ricoh Arena.
Best scored four goals in 19 first-team appearances during his three-year spell with Southampton, while also netting 15 times in 50 appearances during loan spells at QPR, Sheffield Wednesday, Bournemouth and Yeovil..." BBC
Congratulations to Burnley's Clarke Carlisle who makes this week's Championship Team of the Week. (Also in the Team of the week, Colchester's Mark Yeates, who once almost joined QPR on loan.) In League One's Team of the Week, Nottingham Forest's Junior Agogo made it (also with a brief QPR spell) and in League Two's Team of the Week, Macclesfield's Richard Edghill (again with QPR experience).
Daily Mail - September 24
When I get Moore of a run, the goals should flow - QPR saviour's pledge
Stefan Moore is enjoying a new lease of life after granting Queens Park Rangers manager John Gregory a reprieve with his equaliser against leaders Watford on Saturday.
Gregory is believed to have been told he would be dismissed if Rangers lost and his 12-month reign looked to be coming to a close as they trailed to an Adam Johnson goal while out-of-work managers Gianluca Vialli, Micky Adams, Dave Bassett and Gerry
That was until Moore, who worked under Gregory at Aston Villa, saved the day with a 59th-minute strike to earn a 1-1 draw.
"It was nice to get involved and get another appearance under my belt," said Moore, after netting only his third goal in 36 games for QPR.
"I have been in and out of the team and I have never really had a proper run." Mail
Luton Official Site - BOSS SINGS FURLONG PRAISE
Luton boss Kevin Blackwell sang the praises of veteran striker Paul Furlong as he notched his fifth goal of the season against Port Vale.
The 38-year-old displayed his clinical finishing inside the area to sweep home a corner from David Bell.
Furlong, who was released by QPR in the summer, was one of nine summer signings made by Blackwell and the Luton boss believes the striker has become a real success story at Kenilworth Road.
Blackwell said: "His hold up play is so good. Because it is good it allows the three midfield players to get forward.
"It was a quality display from Paul and I have been saying for many weeks now that he is a tremendous acquisition for this Club.
"I don't think people understand the role that he plays, but today people have seen quality hold up play. He also took his goal superbly..." Luton
Fee for Ex-QPR youth player Giles Coke Agreed
BBC - Tribunal sets fee for Coke switch
Giles Coke - Northampton have been ordered to pay Mansfield a package worth up to £70,000 for 21-year-old midfielder Giles Coke.
The Stags are entitled to a fee because Coke is and under 24.
But it has been decided by a tribunal that £15,000 will be paid immediately, with another £15,000 payable in October and a further £7,500 in January 2008.
Another £40,000 will be paid dependant on appearances with £10,000 payable after 10, 20, 30 and 40 games and there is also a 20% sell on clause.
Coke joined the Cobblers on a two-year deal in July after rejecting a new contract with Mansfield. BBC
He started his career as a trainee at QPR, had a spell at Kingstonian and then joined Mansfield in March 2005.
Welcome to QPR REPORT - A completely unofficial and unaffiliated fan site focusing on G-d's Chosen Team, Queen's Park Rangers (QPR) FC. (Visit also QPR Report Messageboard and Follow on Twitter.) QPR Report accepts no sponsorship, advertising or financial contributions. In 2008, QPR Report was named as one of the top two blogs in the Football League
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Tuesday, September 25, 2007
Ex-QPR in Championship Team of the Week...Steffan Moore on Getting a QPR Chance
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- WBA Defeat QPR
- WBA vs QPR: Today's Teams + Gregory Says Not Worri...
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- "Football Aid 2008" Seeks Support
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- The Fall and Rise of Mark Bosnich
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- Blackstock and Bircham Offer Their Views
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- QPR with Bosnich in Goal Defeat Barnet - QPR & Bar...
- Two Ex-QPR Birthdays
- Vialli's Time at Watford
- QPR, John Gregory and The Future
- 'Snippet' re QPR's Shares
- How Ex-QPRs Did Yesterday
- Additional QPR-Watford Match Reports
- Post-Match Comments & Reports re QPR - Watford
- QPR Draw 1-1 Against Leaders Watford
- QPR vs Watford - The Two Teams
- John Curtis on Briatore's QPR Talk...Mark Bircham ...
- QPR Snippets from Venables, Shittu, Mancienne, Shi...
- Ian Holloway on His QPR Victory
- Simon Walton Hopes to Return By End of November
- QPR vs Watford
- QPR Trash - Rangers bottom!
- QPR's Kevin Gallen Turns 32
- Ex-QPR Robbie Steiner on QPR
- Perspectives of Cullip, Ainsworth, Holloway..
- John Gregory: Marking One Year as QPR's Manager
- Gregory to be Axed if QPR Lose to Watford?
- 1967 Hero, Tony Hazell Turns Sixty
- QPR's Plymouth Loss - Further Reports and Comments...
- Nick Ward On Not Playing and Maybe Leaving QPR
- QPR Supposedly Move for Brazil Defender
- Another Home Loss: QPR 0 Plymouth 2
- Teams for QPR vs Plymouth:
- QPR's Dominic Shimmin Trialing with Swindon
- Ian Holloway Looks Forward to Tonights's QPR vs Pl...
- Updated: "Potted History of QPR"
- Three Ex-QPR Birthdays
- QPR's Draw at Leicester - Additional Match Reports...
- Holloway on Gianni Paladini and his QPR Departure
- Stan Bowles: On This Date...At this Moment...Thirt...
- Ex-QPR Captain Kevin Gallen Responds to QPR Chairm...
- Costarcurta and QPR - AC Milan's Coach Ancelotti
- Leicester 1 QPR 1 - Further Match Reports
- 3 Ex-QPR Birthdays...1 Year Since Defeat Marked Wa...
- Axed QPR Coach Joe Gallen Speaking Further
- QPR Draw 1-1 at Leicester (Remain Unbeaten in the ...
- Ex-QPR's Peter Crouch Autobiography 'Walking Tall'...
- Maybe Costacurta to QPR?
- re Costacurta to QPR: QPR "No Comment"
- QPR Look at Leicester....Leicester Look at QPR
- QPR's former Player & Manager, Ray Wilkins Turns 5...
- Former QPR Coach Richard Hill's Ban Reduced
- Ex-QPR's Ian Holloway's Autobiography Set for Publ...
- QPR Birthdays
- QPR Chairman Paladini Interviewed - The Complete I...
- Final Part - QPR Chairman Paladini Interviewed
- QPR Supposedly Want Italian International Costacur...
- Part III - QPR Chairman Paladini Interviewed
- Part II - QPR Chairman Gianni Paladini Interviewed...
- QPR Supposedly Hope to Loan Arsenal Trio
- QPR John Curtis and Mikele Leigertwood Interviewed...
- QPR Chairman Gianni Paladini Interviewed - Part I
- Dave Clement's Son For QPR? The Obstacle to Rowan ...
- Stan Bowles Joins QPR....Thirty-Five Years Ago
- Blackstock Again on the Bench for England U-21s
- West Ham's Hogan Staying at QPR Another Month..Gre...
- England U-19 To Remember Ray Jones
- No Fabio Capello to Manage QPR!
- Sunderland Interest in QPR's Blackstock?
- John Gregory on His Ongoing Loan Attempts & Frustr...
- QPR Taking Part in "Talent From Trash"
- Ex-QPR's Matt Rose Makes 'Team of the Week'
- Three Ex-QPR Birthdays
- Sunday Star Speculates re Ray Wilkins QPR Return
- Ex-QPR Birthdays
- QPR Snippets This Weekend
- Blackstock Makes England U-21 Debut....Holloway on...
- QPR, Ex-QPR and Could-Have-Been-QPR News
- - Lancashire Telegraph - Carlisle makes Clarets vo...
- Big Milestone for Ex-QPR Hero, QPR Manager & QPR F...
- Tommy Doherty's Non-Move to Wycombe
- What Briatore Expects From - and Offers To - QPR
- Ex-QPR Manager Update - Holloway's Book...Francis'...
- ▼ September (128)
- ► 2006 (945)


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Wayne's Automotive
Review for Wayne's Automotive
Ben P. on 12/28/2012
Spoke with Jan. She said they are always ready for her. She can drop off her vehicle at any time. It's ready right away. They do impeccable work. She recommends them all of the time.
Vehicle: Chevrolet Astro
Category: Service
Service Date: 12/20/2012
Review Created: 12/28/2012
This review was collected via phone interview by Customer Research Inc.


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Results 1 to 1 of 1
10-22-09, 12:56 #1Registered User
- Join Date
- Oct 2009
- Posts
- 7
Unanswered: QMF Report Center - Append Data To Excel?
DB2 v188.8.131.522 FixPak 10
Windows XP Professional 2002 Service Pack 2
I want to be able to append data each time a QMF query is automatically run from QMF Report Center to a specific Excel worksheet in a specific Excel workbook so that previously existing data in the worksheet is added to and not replaced. Currently it appears that the only options that I have are to either overwrite the existing data on that worksheet or create a new worksheet with a different name each time the query is run.
Does anyone know if it is possible to append data as described above?


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Home / Pet & Livestock / Pet - Dog / Dog Training / Radio Systems Corp- Sportgod Yard Trainer- Blackq
Radio Systems Corp- Sportgod Yard Trainer- Blackq
SportDog Yard Training Collar for Stubborn Dogs is the perfect sport dog training collar for anyone with a large or stubborn dog. This full-featured training collar is designed for both professional dog trainers and the average pet owner. 100 Yard Range.


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Shellback Commemorative Medal
Finally a Commemorative medal struck to honor those who have earned the title: Trusty/Honorable Shellback, often referred to as a Son of Neptune
In the U.S. Navy and Coast Guard, when a ship crosses the equator at latitude 00 00 there is a Naval tradition and event no former polywog ever forgets. Those who have been found worthy and inducted into the "mysteries of the deep" by Imperium Neptuni Regis and his Royal court, count the experience as a highlight of their military career. Members of Neptunus Rex's party include Davy Jones, Neptune's Royal Scribe, Her Highness Amphitrite his Queen, , the Royal Doctor, the Royal Dentist, the Royal Baby, the Royal Navigator, the Royal Barbers, the Royal Judge and other such members of his household that suit the royal party.
The rich Naval ceremony honoring sailors crossing the equator goes back centuries when such a feat was a grave undertaking and test for those who had not sailed across the equator. The ceremony often involved two days of events throughout which Pollywogs (or Wogs for short), the term given to those who have not crossed the equator before, are put through a series of initiation rites involving demanding and often embarrassing tasks, gags, obstacles, physical hardships, and generally good-humored hazing. The two-day event is a ritual in which previously inducted crew members called "Trusty Shellbacks" are organized into a "Court of Neptune" to induct the Slimy Pollywogs into "the mysteries of the Deep. If the wog passes Neptune's test there is an elaborate ceremony with much pomp and the sailor is inducted into the "Solemn Mysteries of the Ancient Order of the Deep" and passes from Wog to Shellback.
Official entries indicating date, time, latitude and longitude are recorded in individuals service record. The day ends with each of the new shellbacks receiving elaborate certificates testifying to their safe passage, along with a wallet-sized card to prove the fact on future cruises. They who lose their cards may soon find themselves climbing back into a wog pool on their next deployment.
All pollywogs, even the Commanding Officer if he has not crossed before, must participate.
The Crossing the Line ceremony is a special maritime experience, a relic of the of wooden ships and iron hard Sailors who venture into the unknown environment of the open ocean. The ceremony, as old as perhaps the very art of sailing, in all its pomp and unique charm and history, will hopefully remain an equatorial pastime to be treasured by generations of Sailors to come, so that they too can laugh about a chief they know who's wearing a swab for a wig, holding a makeshift wooden trident, and speaking magnanimously about Pollywogs and Shellbacks and the "Ancient Order of the Deep."
"The sea is eternal and sacred, and so are the traditions that accompany it,". "As long as there are imaginary lines by which sailors travel, we will attach a special significance to crossing over them, a significance which bonds all blue water sailors together."
Where do these colorful characters come from? Neptune (or Neptunus Rex, as he refers to himself during the ceremony) is the Roman sea god, who originated as the god of fresh water but later became associated with the Greek sea god Poseidon. Poseidon was one of three sons of Kronos: Zeus, Hades, and Poseidon were said to have cast lots for the three kingdoms of heaven, underworld, and sea. He generally appears with a trident (a three-pronged spear) and his consort, Queen Amphitrite. Triton, a merman son of Poseidon and Amphitrite, occasionally appears in crossing the line ceremonies as well.
Davy Jones has a number of stories concerning his origins. The Australians tell a tale of a fearsome pirate who sank to the bottom of the sea when crossing the equator and "now patrols the equator on his killer whale boarding any vessel that dares to pass the waters of the Kings Majestic Realm." Some ceremonies list Davy Jones as King Neptune's Royal Scribe, who verifies that each wog has indeed crossed the line. The most common tale is that he is the evil spirit of the sea, whose name came from a corruption of " Duppy Johah," duppy being the African West Indies name for "spirit" or "ghost" and Jonah being the Old Testament prophet who was thrown into the sea. To go to "Davy Jones' locker" is to be buried at sea. A third explanation comes to us from the British, along with a vivid description of his appearance in the Crossing the Line ceremonies:
Some English sailors incline to the belief that his name is a corruption of Duffer Jones, a clumsy fellow who frequently found himself overboard. The only time Davy comes to life is in the ceremony of crossing the line. Then he is usually impersonated by the smallest sailor on board, given a hump, horns and a tail, and his features made as ugly as possible. He is swinish, dressed in rags and seaweed, and shambles along in the wake of the sea king, Neptune, playing evil tricks upon his fellow sailors.


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How to manage time between your assignments, exams and college fun?
Time management can be a common problem and one of the important tasks in the life of any student as the ability to prioritize is the key to maintaining a harmonious and balanced lifestyle. Time management is defined as the act or process of planning and exercising conscious control over the amount of time spent on specific activities, especially to increase effectiveness, efficiency or productivity. Time management helps you to calm that chaotic schedule for a stress-free college degree. The importance of time management is increasing especially for students who at this age juggle between different priorities of life such as study, work, and family. Good time management brings plentiful benefits that will make things easier for you. College life is like juggling many balls at a time and trying not to drop any of the balls, so ReviewAdda.com has arranged some tips for managing your overcrowded schedule:
One last tip, focus on working smarter never run after and focus on getting things done. Your ultimate goal should be to arrange commitments in a way that you are happy living out the details of your daily life, even while you are working.


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Yoga Teachers Training Course
Yoga Instructors'Course (YIC)
The Yoga Instructor course consists of the following the subjects which transforms the students could able to learn yoga and provides the platform to teach the yoga individually. This certificate a course affiliation from VYASA, Bangalore, recongnized course.
The course presents a practical approach to classical Patanjali Astanga Yoga and Hatha Yoga practices of including Asana, Pranayama, Mudra, Bandha, Relaxation, Kriya and Meditation.
- YIC course has been specially designed so that within tree month part time, a person feels capable, comfortable and sufficiently knowledgeable to be able to teach yoga, in a practical manner for working class people and house makers also.
- The YIC course introduces the concept of right way of living, which can be easily translated, into their lives.
- The YIC course is the flagship course to make individuals as professionally qualified Yoga instructors and prepare students to progress onto other long term courses at S-VYASA Yoga University.
Age Group: 18 to 60 years
Eligibility: Intermediate or 10+2 education
Course Duration: 3 Months
Option 1 (Week Days): From Monday to Friday 5:00 A.M to 7:00 A.M
Option 2 (Week Ends): From Saturday to Sunday 5:00 A.M to 10:00 A.M
Venue: Plot No: 62, 4th Floor Sri Tower, JNTU-Hitec City Road, KPHB 7th Phase, Land Mark: Near Ankura Children Hospital
Upon successful completion of the course, students will receive a diploma in their area of study. Our diploma is a highly valued and internationally recognized certification presented by the International Manavata Yoga Research Foundation with the affiliation VYASA University, Bangalore.
Introduction to yoga and its' streams (2 credits)
Life and Message of Spiritual Masters and Applications of Yoga (2 credits)
Concept of yoga
Introduction to yoga
Teaching Methodology
Principles of teaching
Theory and practice of yoga Asana:-
24 classical asanas.
Anatomy and physiology
Jala neti
Sectional breathing
Meditation and chanting :-
Devotionals songs (bhajan)
Mudra and Bandha:-
Follow by Asana, paranayama,
- As a yoga instructor, you will become a living guide through which the many aspects of yoga can be experienced by those seeking physical, mental and spiritual well-being.
- As a yoga instructor, you will not be confined to practicing in a particular place as it can be performed world-wide and you can take your career with you wherever you go.
- As a yoga instructor, you will be able to practice and improve on your problem solving skills as well as organizational skills as you strive to become a better teacher.
- Yoga is a noble profession as it helps those in need to obtain health and peace of mind in order to deal more easily with life situations.
- Responsibility comes with leadership and the satisfaction of being self-employed. Through the daily routine of practice session, handling your business affairs and being in charge of your own health, career and finances, an independent mindset will become ingrained in your everyday life.
Suitable for newcomers to yoga, it is not necessary for the student to have any prior knowledge or experience of yoga. Classes start at the Beginners' Level and progress through to the Intermediate Level.
- Making Yoga a Socially Relevant Science: As a professional Yoga instructor, you would have an opportunity to impact the lives of many people on a daily basis through Yoga based lifestyle modification. You can inspire and motivate many to lead their lives with right habits, mental conditioning and stress-free life.
- Add Sadhana to your Practice: Students come to class looking for guidance, but they also give back to you (as the teacher) an incredible amount of energy and insight. Teaching is a powerful way to deepen your own practice and understanding of yoga. This is the only profession you are paid to take care of your own health as each session can add to your wellbeing.
- Enjoy a Flexible Schedule: Pursue a carrier which is flexible unlike a full time stressful conventional job. As a Yoga instructor you're also pursuing your passion and will also have time to pursue other interests.
- Earn a Good Salary: Years ago, most yoga teachers hardly earned enough to get by; but today teaching yoga can make you financially comfortable.
- Live and Breathe Yoga: Doing Yoga will enable you to understand and have a healthy lifestyle. There's nothing more powerful than having a positive peer group, and for many this often leads to a remarkable change in your personal health and lifestyle.
AboutManavata Hyderabad Chapter Service to Man is Service to God
Manavata (Humanity) Is A Symbol Of Selfless Service, Empathy And An Attempt To Help The Needy. Manavata Is A Non Profitable, Non Religious Voluntary Organization Working For The Development Of The Society. It Is A Common Platform For Many Volunteers And Social Service Organizations.
Event Details
Yoga Teachers Training Course event is conducting at Plot No: 62, 4th Floor Sri Tower, JNTU-Hitec City Road, KPHB 7th Phase, Land Mark: Near Ankura Children Hospital on Sunday, 30 Apr 2017 . Please find the detailswhich mentioned below for any clarification please contact the following contact number or drop a mail to email@example.com.
Venue Details
Where : Plot No: 62, 4th Floor Sri Tower, JNTU-Hitec City Road, KPHB 7th Phase, Land Mark: Near Ankura Children Hospital
When : Sunday, 30 Apr 2017 to Monday, 31 Jul 2017
More Details : www.manavata.org
Email : firstname.lastname@example.com
Phone : 9966673111
No Updates to this Event!


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Build Guide by DrS
This build has been archived and is for historical display only.
PLEASE NOTE: This build has been archived by the author. They are no longer supporting nor updating this build and it may have become outdated. As such, voting and commenting have been disabled and it no longer appears in regular search results.
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Jarvan IV Build
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
This is my first guide ever so please give any feedback and comments you have. Anyway here it goes.
Jarvan is a tanky/dps that means two thing
a) he can tank
b) he can dps
So you can have both!!! (no @#%$@ Sherlock) and since everybody fancies a kill dps a little more.He is tankY and not a TANK! Dont bother with magic resist or armor you are wasting his potential.
If you are not into reading just check the TIPS chapter for a rough guide about Jarvan
Early Game
Level your Demancia Standard in order to scout the bushes and get that kill if things turn out good in your lane.
Get a [Ruby Crystal] just to have enough health to stick to your lane untill you have that 500 gold to upgrade it into a [Heart of Gold]. I recommend to go back and get it as soon as get 500 gold because in the long run you are going to have some serious cash out of it (5g/10sec 30g/min). Also heart of gold boosts your lane survivability.
Once you gather 1350g go back get [Tear of the Goddess] and [Boots of Speed]. Remember to spam your three first skills whenever you go back in order to feed your "tear".
Grab a [Zeal] after that, the extra movement spead is a god sent gift + the extra attack speed
Mid game
At this point you are going to need some extra health since you already happen to be the fight initializer or soon you are going to be. Grab a [Warmog's Armor] + your health runes you are going to have a nice hp pool to walk around and kill staff.A [Leviathans] would also be nice. If you are good enought and score soem assists or kills your next item got to be an [Atma's Impaler].
Late Game
Here basically you boost your physical damage even more. some people would like to go for a [Madred's Bloodrazor] for the attack speed and the stacking up it does with Jarvan's passive but i prefer [Infinity Edge] since you get attack speed from boots + Demancia Standard+Zeal. The game should be over soon but if there is still time finish your [Phantom Dancer]. If the game is longer than usual a Bloodthirster is there for you, then you are practically immortal.
i wont go much into it. armor penetration for physical damage is the way to go.
For the yellow runes i prefere health/level in order to feed [Atma's Impaler] more and increase survivability.
Attack Speed/level is just my thing. So these runes + Demancia Standard is all you need when it comes to attack speed so you can boost other stats
Armor penetration Quintessences for me because these 3 + the Red ones will give you enough so as not to bother with armor penetration items if you are up against normal champs (no tanks i mean by that)
Again here it's a normal physical damage dealer build with the extra points to utility for a little bit of that tanky bit.
Summoner spells
Flash is the best spell out there for almost any champion. Use it to get close and use either your E+Q ability or to R someone. It is also very very helpful to get out of squishy situtations and out of your ulti when things are going bad!
Exhaust is just and addition to your shield slow....they practically wont be able to move if you apply both. you can also use it to slow an emeny down after your ulti ends and still you havent got the kill. You can replace it with ignite for more aggresive play!
i max out Demancia Standard at any given chance. It's a nice range damage and the buffs are really good to sustain dps on a target
After that Dragon Strike comes. It has a great damage output and will help you get some nice kills as you level it up
Last but not least Golden Aegis the only reason i dont level it is because i have some basic knowledge and experience on how to survive so i dont need the damage migitation that badly and i use it for the slow most of the times.
i cant tell you how to play Jarvan this is up to you, but here are some usefull tips
-Master E+Q combo litteraly reach a point that you do it without even realising how difficult it might be.
-Dont just do it to charge in..try to master it also while fleeing and you are moving away from an enemy
-E+Q over thick walls!
-Dont be afraid to flash out your ulti you got plenty of damaging skills and attacks you ulti is just one of them
- Yes you can slow people on the other side of a wall with your shield if they are close enought
-This is a guide not a one way road, weight your opponents and buy things according to the situation
-Switch targets when thats doable...use your passive
-You can interupt Katarina's ulti with E+Q and you can stall someone long enought to get hit by the turret..(you have exhaust too!!)
-DONT FEED this build unfortunately requires some cash and timming....so if you are left behind because you die too much in terms of cash you will probably left behind in damage output while others will pwn you over and over and wont feel any pain from your little spear


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Tell us if someone is bullying you. If we know about it we can help. Do not worry about telling us and do not suffer in silence.
If you are being bullied or if you know someone who is being bullied you can:
talk to your tutor
talk to your Head/Assistant Head of Key Stage
talk to another member of staff
talk to your parents
fill in the form below and send it to us
Anything your write in the form will be confidential
Some kinds of bullying
Using your body - pushing, kicking, taking someone's belonging, being violent
Using words – name-calling, making threats, making unpleasant or rude comments
Being unfriendly – refusing to talk to someone, gossiping, spreading rumours
Cyber bullying – sending bullying messages by text, phone calls, video-clips, email; using Facebook, Twitter or website to spread rumours or to make unpleasant comments.


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Senate reports $5 million in campaign coffers, but below 2012 pace
Republicans said Tuesday they have raised $3.7 million in the last six months to defend their hold on the state Senate.
GOP spokesman Scott Reif said the Senate Republican conference will report having "nearly $5 million" in its main campaign accounts when it files with the state Board of Elections. That will be slightly less than the $5.4 million Senate Republicans had in hand in July 2012.
Senate Democrats reportedly will have slightly more than $1 million. They also said they now have eliminated lingering campaign debts.
Tuesday is the deadline for all statewide candidates, legislative candidates and fundraising committees to report money raised and spent over the last six months.
The state Senate is the GOP's remaining power base in state government.
At this point in the 2012 campaigns, Senate Republicans reported having around $5.4 million in their campaign accounts, after raising about $2.3 million during the first six months of that year.
In a statement, Senate Republicans said garnering $3.7 million in contributions since January shows New Yorkers don't want Democrats running both houses of the state Legislature.
"The strong bottom line, which includes a hefty $3.7 million raised in just the last six months, shows New Yorkers are concerned about a return to an all-Democrat, all-New York City government in Albany," the party said.
Josh Cherwin, spokesman for the Senate Democrats' campaign committee, noted his side was outspent in 2012 yet won all the closely contested races. He said Democrats are closing the fundraising gap.
"Senate Republicans' support is waning from year to year because New Yorkers realize they controlled the Senate for almost 50 years and the results have been higher taxes, jobs fleeing the state and more unfunded mandates," Cherwin said.


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Software (GUI) Engineer
LOCATION - Tokyo, japan
This job is to create a graphical user interface (GUI) for the next-generation of spacecraft and planetary rovers for ispace, inc. The ideal candidate will have a broad knowledge base including an understanding of hardware and robotics and design of communication networks. The job includes all phases in design, from defining system architecture, to implementation of the GUI, to operation of the rover during simulated and real missions. Prior experience with high reliability designs (for example in aerospace, medical or automotive industries) is a must.
- Participate in product definition, specification and requirements phases
- Design, code, integrate, test, support and enhance software solutions for the GUI to control robotics
- Support integration of the GUI to all devices in the system including intermediate communication layers and embedded Linux systems running on the robotics hardware
- Develop and enforce coding standards that allow for automated and/or external auditing of software code
- Develop and support specifications for data transfer between spacecraft and rovers to and from the ground station
- Work with graphical designers and consult current research to optimize the GUI for safe human operation and efficient data transfer
- Bachelor's degree in Computer Science, or equivalent
- 5+ years of experience designing and coding
- Proficient in high-level structured programming languages (e.g. C, C++)
- Experience with communication and networking protocols (I2C, SPI, RS-485, CAN, etc)


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|The following is based on Fallout: New Vegas cut content and has not been confirmed by canon sources.
Nellis Artillery Shell is a type of ammunition in the game files of Fallout: New Vegas.
The Nellis Artillery Shells are very similar to Mini nukes, but can only be fired from the Nellis Artillery, a special variant of the Fat Man. The exact purpose of this ammunition is unknown.
pc Nellis Artillery Shell can only be obtained with the use of console commands.
Nellis Artillery Shell only appears in the gamefiles of Fallout: New Vegas.


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Linesides on Top
- Format: DVD
- Release Date: 9/16/2008
|your cart is empty
Some of the most exciting fishing, regardless of species, is watching them explode on a top water plug. Line sides on Top shows you the types of lures, tackle and techniques to use to catch stripers on top water. Captain Mack Farr reveals his proven tactics to entice schooling stripers to take a plug. Captain Mack gives in-depth information on plug types, retrieval styles and when these patterns are most effective. This program is freshwater striper action on impoundment's and reservoirs is at it's best!


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25 Monsters Set loose in Boston
A free weekend all you have to do is make sure the students do not get in trouble and you be responsible for all the little monsters. I am the only teracher at FIT that seems to be up for such a trip each year. I kind of get along with the students they are pure energy and fun to be with. Did I mention that this is the hotel that the Craig list murder occurred recently.
Capturing the city while it sleeps
Really liked this sculpture
This is Copley and he was of all things a portrait painter very popular in Boston,Boston
Loved his one ,the wearer generally makes the costume he or she wears
This little one was adorable this was just one of her costumes, many at the convention arrived with multiple outfits, Their were over eleven thousand in attendance at this event.
Not knowing anything about Anime I just kind of felt like this was a little bit of dipping into the work Dr Zeus
I believe this is the Lolita style
Anime is the current plague of all the drawing teachers because it is drawing from cartoons rather than life . However in this case the students actually became entrepreneurial and made some money over the three-day event. This is a small nitch that they could fill drawing convention attendees as the anime personality they viewed them selves as, nice to see
Loved this public sculpture it was massive and appeared to be made from actual locomotive engine parts sweet.
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Happy July 4TH
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I was excited to see this post from Sriram about DirectWrite today. I'm also glad to see that he'll be PM'ing the DirectWrite effort. He's a former WPF guy, now on the Windows 7 team—a good guy to make sure that DirectWrite (a Windows7 API) gets well represented in WPF and (please!) Silverlight.
At this point, I think I would take better text support over any other feature in Silverlight or WPF. Yup. You guys can have blend modes, effects, 3D, and everything else I have asked for (or even hinted about) if it means I get awesome text.
The problem is that I start my designs in Photoshop and, frankly, Photoshop has a great text engine. By the time I get to production, I'm just about always disappointed. To my eye, WPF text rendering doesn't even come close and Silverlight is losing its socks. Sorry xaml-based technologies. You know we're still friends, right? I'm just trying to help you grow.
By now, I (probably like you) have learned which are the "safe" fonts and the safe sizes in WPF, and I stick with them. By doing that I can get some okay looking text that works with most of my apps (incidentally the Ascender fonts that shipped with the SDK are great!). But, frankly, the importance of text in a UI can probably not be overstated and I'm tired of feeling like I'm settling. In Silverlight, I rarely even use the text engine. In most of the projects I've done, I've pre-rendered the text into images! That's a sad state of affairs.
So, here's my wishlist:
- Awesome type that looks great at any size and any weight with any well-constructed font (if the font is bad then we both agree that you can only do what you can do)
- More developer control over the qualities of the rendering (let me control just how much sub-pixel rendering and how you do it—let me call the shots about perf and readability)
- A WPF story (I think Scott Guthrie said something about this at PDC, right?)
- A Silverlight story (ideally we'd get the same engine or at least some of the awesomeness even if we don't get the tweaks)
- A downward compat story (it would be a real bummer if this only showed up in Windows7—it means it's not something that I can rely on and I end up back with my safe fonts. Or, worse, I end up with a smaller set of safe fonts that work in both rendering environments—in that event, things got worse and not better).