text: Hello to all, I purchased a tri-ex lm354 from Rick's neighbor a fellow ham. I ALSO bought from Rick a UStower MA-550 tower. I hired and paid RICK in full for his tower($600.00) and another $200.00 to re-cable the lm-354. Well, all of that was in March/April 2015. Rick said the work would take a few months and then I would pick up both towers. Well, here it is March 2017, after MANY text messages and phone calls I was finally allowed today 3/19/2017 to pick up my towers. Well, Rick wasn't there, my LM-354 tower WAS NOT re-cabled and my usTower ma550 was NOWHERE to be found!! So Rick stole my $600.00 for the ma-550 and stole the $200.00 for the work! Now I have a worthless tower and missing a tower! I have a canceled check that Rick accepted for payment and many text messages as proof! Rick to date HAS NOT returned my many calls. Please DO NOT DO BUSINESS with this GUY! He took advantage of me being sick and fighting cancer! I'm sorry I trusted HIM! 73 de NE6V Joe


text: Thank you for stopping by to check out the latest project tutorial about how to make a wood coffee table with steel accents. The project is fun to create and simple to build. I love combining different materials and think the steel and wood compliment each other well. To seal the cedar I used the water-based […]Continue reading

subset: commoncrawl


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Fit for Work is a new service, introduced in December 2014, which aims to help employees stay in work when they are ill and to return to work more quickly when they have been off sick for four weeks or more. It will mainly target small and medium sized enterprises and will sit alongside employers' existing occupational health (OH) services. This factsheet looks at how the new service will work and what action you need to take.
In February 2011, Dame Carol Black and David Frost CBE were appointed to undertake a review of sickness absence. The review was aimed at identifying ways of minimising loss of work due to ill health and finding ways of reducing the associated burdens and costs on individuals, employers and the taxpayer.
he report, "Health at work - an independent review of sickness absence", was published in November 2011. It made a number of recommendations to improve sickness absence and reduce associated costs, including establishing a new Independent Assessment Service which, after an employee had been absent for four weeks, could provide expert advice on whether and, if so, how the employee could be supported in a return to work. This recommendation was accepted by the Government, which announced that it was going to establish a new Health and Work Service. This was renamed Fit for Work in October 2014, to describe its purpose more accurately, and was launched in December 2014.
The service is being delivered in England and Wales by Health Management Ltd and in Scotland by the Scottish Government via NHS Scotland
Fit for Work is a new free service, funded by the Government, which helps employees to stay in or return to work. It will be phased in by May 2015 and includes two elements: advice and referral.
Employees will normally be referred by their GP but an employer can make a referral after four weeks of absence. Employees can refuse to consent to a referral. The OH assessment will usually be done over the telephone and will result in a plan to get the employee back to work. The employee has to agree to the plan being shared with their employer and GP. The employer does not have to accept the plan or implement any of its recommendations.
The service is intended to work alongside and not replace existing OH services
Advice service
This provides free health and work advice through a website and a telephone line. It was launched on 16 December 2014 and can be accessed here: www.fitforwork.org. The helpline number for England and Wales is 0800 032 6235 and it is open from 8.30am to 6pm Monday to Friday.
In Scotland, the website is www.fitforworkscotland.scot. The telephone number is 0800 019 2211 and the advice line is open from 9am to 5pm Monday to Friday.
Referral service
There will be a phased roll out of the referral service, which is due to take place over several months starting in early 2015 and finishing by the end of May 2015. It will provide a free referral for an OH assessment for employees who have reached, or whose GP expects them to reach, four weeks of sickness absence. The service will help employees return to work sooner. Employees will normally be referred by their GP.
Employers can also make a referral after four weeks of absence. It is not mandatory for employers to refer employees to Fit for Work. In order for an employer to make a referral, the employee must have been absent from work for four weeks due to illness and have a reasonable likelihood of making at least a phased return to work within three months. An employee will not be eligible if: they live outside England, Wales and Scotland; they are not absent from work; they have been referred to the service within the last 12 months and received a return to work plan as a result; their GP has already referred them; or they do not consent to the referral.
Employees will be referred with their consent for an OH assessment, which will be done by an OH professional and will usually take place over the telephone. Employees will be contacted within two working days of a referral by their GP or employer. If a face to face assessment is deemed necessary, this will take place within five working days of the decision being made.
The assessment will result in a return to work plan, which will include advice and recommendations for the employer, the employee and their GP to help support a return to work. The assessment will try to identify all potential obstacles preventing the employee from returning to work, including health, work and personal factors, and will involve agreeing a plan designed to address each obstacle and enable a safe and sustained return to work. The plan will be shared with the employee and, with their consent, with their employer and GP. If appropriate, the OH professional may contact the employer to discuss factors that might help to develop the return to work plan. Any existing OH service will be incorporated into the plan and will be used to facilitate recommendations within the plan.
The OH professional will contact the employee to check that the plan is on course and will also contact the employee shortly after the expected return to work date. A further assessment may be necessary and the plan may be revised. Fit for Work involvement will last for three months.
Employers can accept a return to work plan as evidence of sickness absence in the same way as a fit note issued by a GP and will not need to ask employees for further fit notes as well. It is not mandatory for employers to implement the recommendations highlighted in the return to work plan, unless this is required to meet the employer's obligations to make reasonable adjustments under the Equality Act.
It is not mandatory for employees to engage with Fit for Work and they will need to provide consent for a referral, before an assessment takes place, when Fit for Work wishes to contact their GP or employer and before a return to work plan is shared.
Tax exemption for medical treatment
From 1 January 2015, a tax exemption is available for employees of up to £500 per tax year where their employer pays for medical treatment to help them return to work. The treatment must have been recommended by a healthcare professional as part of Fit for Work or the employer's OH service and must be intended to help the employee return to work after a period of absence due to ill health or injury.
On 2 January 2015 the DWP published guidance for employers on using Fit for Work to help their employees stay in or return to work. The guidance can be accessed here: https://www.gov.uk/government/publications/fit-for-work-guidance-for-employers. It will be updated as referrals begin to be accepted for OH assessments, to reflect the roll out across Great Britain. Separate guidance has been produced for GPs and for employees.
Checklist for employers
You should consider taking the following actions:
- update your sickness absence policy to reflect the availability of Fit for Work
- train managers on the new service so that they are ready to handle referrals and return to work plans
- liaise with any existing OH provider
- ensure that a reminder is triggered when an employee has been off sick for four weeks so that you can consider referring them for an assessment if their GP has not already done so


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A leading international bank engaged Rainbird to build a tool that any employee could use to answer client questions and resolve problems with complex recurring payments. Rainbird was integrated with IBM Watson to deliver a chatbot that can solve over one hundred different trajectories of enquiry.
An international law firm selected Rainbird to build and deploy a self-assessment tool for any of their customers affected by changes in legislation. They selected Rainbird's cognitive reasoning engine because of its ability to apply existing human knowledge to problems, and provide a rationale for every automated judgement made.
Rainbird was engaged by a leading global accounting firm specialising in audit, tax, consulting, and financial services. After a successful proof of concept delivering a tool that successfully augments back-office workers, Rainbird is now building a Rainbird Centre of Excellence enabling enabling the organisation to scale cognitive solutions in their tax practice.
Rainbird's team worked with Fluid Motion's qualified Physiotherapists and Osteopaths to encode their model of patient treatment in Rainbird, including the suitability of numerous exercises to individual patient symptoms. The resulting knowledge Map was then integrated into a mobile front-end that could be accessed by Fluid Motion's network of Fitness Instructors.
Identifying who was at fault in a motor accident is a difficult task and an historical area of weakness in the motor insurance industry. Rainbird takes each claim's data and compares it with AIS' model created in Rainbird. The result is an accurate judgement, using a probabilistic cognitive reasoning model similar to that used by human experts.


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My Nonprofit Reviews
Review for Global Exploration for Educators Organization, Ardmore, PA, USA
I have traveled with GEEO to India, Nepal, South Africa, Mozambique, Zimbabwe, Botswana, Thailand, Vietnam, Laos and Cambodia. Each of my trips has been an unique adventure which has furthered my knowledge and life experience. I highly recommend GEEO.
More Feedback
If I had to make changes to this organization, I would...
Research the hotels better and give more explicit directions and information concerning trips where you need to leave your big bag and require a small bag for overnights.
Would you volunteer for this group again?
For the time you spent, how much of an impact did you feel your work or activity had?
A lot
Did the organization use your time wisely?
Very Well
Would you recommend this group to a friend?
When was your last experience with this nonprofit?


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- Please select a date to see the proper prices!
Description of the accommodation:
Rooms, services Kohlerhütte Hütte Klagenfurt is offering two nicely furnished rooms to stay in to those seeking accommodation in Klagenfurt. If you wish to learn more about the exact scope of services provided by Kohlerhütte Hütte Klagenfurt (including any available for an extra fee), you will find them on the information sheet below.
Payment Credit card guarantee or advance bank card payment may be required for the reservation, depending on the chosen room, date and price.
Arrival, opening hours The personnel of the hotel can speak with you in English and German languages.
Kohlerhütte Hütte Klagenfurt rooms Rooms
- Please select a date to see the proper prices!
Accommodation services
- Finnish sauna
Pet friendly


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Photo: Churchgate, Southport, Tuesday February 2 2016
Gale force winds have ripped across the Southport over the last 24 hours thanks to Storm Henry.
A Churchgate resident said: " We heard an almighty cracking noise, looked out and the tree was down".
Sefton Council are aware of the incident and have assured residents that it will be cleared later this morning.
Submit News Contact us with your community, business or sport news. Phone 07581350321
Email email@example.com
Facebook www.facebook.com/otsnews.co.uk
Twitter www.twitter.com/onthespot_news
Breaking local news as it happens, searchable archives with photographs, the ability to instantly comment on news articles – there are so many advantages to OTS (Onthespot) News.
If you want your news read locally online then send it to email@example.com – relying only on the newspaper is to restrict yourself to an ever reducing audience.


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I'm an artist based in Austin, Texas. I didn't really have a chance. My mother is a Trekker painter/singer. My late father, a classical music composer, was also a science fiction literature aficionado. This resulted in a childhood with teeth cut on Edgar Rice Burroughs novels while Star Trek re-runs ran on the television. My brother ran away from home to become a doctor.
I love stories, especially those in the genres I was raised in. I also love creating stories, whether it be with a single image or through sequential art. When I'm not drawing or painting, I'm either in the gym weight-training, writing, or horseback riding.
- Artist's Website 'About'-page


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adorable pics of valentina & being cold and wet
Medellin Travel Blog› entry 7 of 19 › view all entries
The day started with a nice little jaunt around the neighborhood with my favorite little Colombian :) and her abuela(her grandma = my friend dianas mom)(val is diana's niece). during our excursion when we were checking out a church on the campus of UPB(a university) there was a downpoor of rain for a while so we hung out until it let up a little(until the rain was lighter, as we forgot to bring umbrellas). The clouds move through the valley pretty quick in Medellin, so if its a bit cloudy or overcast its best to be prepared. it doesn't usually last long, but its tropical there so when it rains, it really pours. (it comes down in buckets:)
In the Evening a bunch of CS folks and myself met up to take a bus up the mountains to a place called "Santa Elena" where they use the flowers to make floats and big round displays for the parade .
still need pic of poncho


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Its 2017 and Nigerian men are quickly upping their fashion games. The top designers are releasing catalogs of outfit styles for men. Some are catching our attention while other are downright wack.
One thing is certain, the average Nigerian man is developing a more refined taste in style and it is evident in what they wear to events, parties and even on the streets of the cities.
Recently a fast rising designer released his 2017 fashion collection for men and we are super-impressed. He calls the collection the "Monotint"- mainly because they are all black and white.
Everyone knows that black and white are classic colour.Just take a look at the ways All black agbadas look stylish and all white agbadas look regal in these pictures. So it comes as no surprise that these designs are the perfect roadmap for any Nigerian man who is looking to be stylish in the year 2017.
Take a look.


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"We don't need to go to the Christians or the Jews debating with them about the filth which they believe. We Muslims have been ordered to do brainwashing because the kuffaar they are doing brain defiling. You are watching the kaffir TV and your wife is watching it right now and your children are watching it and they are being polluted and they are being penetrated and they are being infected, so that you come out of the house and your children come out of the house as Muslims and come back as kaffirs."
"There's no such thing as a Muslim having a non-Muslim friend. If you prefer the clothing of the kafirs over the clothing of the Muslims, most of those names that's on most of those clothings is faggots, homosexuals and lesbians."
"A non-Muslim associate doesn't understand, doesn't embrace your values."
"An AIDS virus that is a classic disease that was created in Fort McKinley, United States. Fort McKinley, the AIDS virus, 63,000 gallons. Missionaries from the World Health Organisation and Christian groups went into Africa and inoculated people for diphtheria, malaria, yellow fever and they put in the medicine the AIDS virus."
"The Koran gives a very clear position regarding homosexuality, lesbianism and bestiality – that these are aberrations, they are immoralities and if they are tried, convicted, they are punishable by death."
"Then people can see, people without hands, people can see in public heads rolling down the street, people got their hands and feet from opposite sides chopped off and they see them crucified…they see people put up against the pole and see them get lashed in public they see it, and because they see it, it acts as a deterrent for them because they say I don't want that to happen to me."
"Nowadays, whenever anybody visits some of the Muslim countries, they find that the circumstances within them are quite different to what they would have expected. One only needs to set foot in these countries and begin to wander their streets to witness the tragic behaviour of its inhabitants.
When one observes the level of joy and ecstasy as the different classes of people within the Muslim communities prepare to receive Christmas and New Year's Eve, it seems impossible to believe what one previously heard about the Muslim countries and how its people were adhering to Islam.
The entrances of hotels, cafés and stores are festooned with Christmas decorations; photographers dress up as Santa Claus and go around taking souvenir photos of people; florists compete in selling their produce for people who rush to buy it for this occasion regardless of the price. Some Muslims prepare to hold parties in their houses and hotels and these hotels have tempting special offers for people to hold their parties in their halls and party rooms during that period.
The fact of the matter is that all of these actions represent a comprehensive imitation of western culture and can only be the result of very low levels of faith or indeed a total lack of it; to exhibit this type of behaviour is to strip oneself from the distinction and superiority of Islam and it is also an evil which makes Muslims who partake in such celebrations be included in the saying of the Prophet sallallaahu `alayhi wa sallam ( may Allaah exalt his mention ): "He who imitates a people will be from among them (on the Day of Judgement)." [Abu Daawood] And in another narration, he sallallaahu `alayhi wa sallam ( may Allaah exalt his mention ) said: "The one who imitates people other than us (i.e., in faith) is not from us. Do not imitate the Jews or the Christians."
[Tirmithi]Imaam Ahmad may Allaah have mercy upon him said:
"The very least that this Hadeeth entails is the prohibition of imitating them (i.e., the Jews and the Christians); although it is also apparent that the Hadeeth labels the one who does so as a disbeliever (as Allaah Says what means): "O you who have believed! Do not take the Jews and the Christians as allies. They are [in fact] allies of one another. And whoever is an ally to them among you – then indeed, he is [one] of them. Indeed Allaah guides not the wrongdoing people." [Quran 5: 51]
When Muslims imitate non-Muslims their rank in the Sight of Allaah decreases. This is because a Muslim is superior to a disbeliever, so if he were to imitate a disbeliever then he would descend from his lofty rank to that which is inferior and this is a form of being ungrateful for the bounties of Allaah and an insult to the religion of Islam because Islam is superior to everything else and nothing should be given priority over it.
Islam has established a path to guidance which differs from the culture and customs of the disbelievers regardless of whether they are from the people of the book or otherwise. Islam abrogates all previous religions and legislations and our Muslim nation is the one to be followed and not one which should blindly imitate others.
Imaam Ibn Al-Haajj may Allaah have mercy upon him mentioned in his book which mentioned the sayings of the Maaliki school of opinion in Islaam: "It is not permissible for any Muslim to sell the Christians anything distinctly used during their religious celebrations, whether it is meat, grease or clothing; they should also refrain from assisting them in any of the affairs of their religion, because this is a form of honouring disbelief and aiding them in their disbelief and the Muslim leaders should forbid the Muslims from doing so. This is the ruling of Imaam Maalik and others and I do not know of any Islamic scholar who differed with this ruling."
It is our religious duty to boycott these celebrations; are we unable to prevent our children and other members of our household from participating in these immoral celebrations?


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"This is a need to know reference to orient therapists to the role of imaging procedures....it is a useful resource and offers nice clinical pearls to apply the information presented."Doody's Review Service
"...a very useful reference text for both the practicing physical therapist as well as the physical therapy student....The illustrations, and especially the CD-ROM, do an excellent job of depicting points brought up in the text and greatly enhance the clarity of the information. I have found the CD-ROM images to be valuable tools in patient education and in clarifying pathology for physical therapy students."Journal of Orthopaedic and Sports Physical Therapy
This unique book enables therapists to understand the various imaging technologies and weigh the benefits and drawbacks of each in the context of their own screening and evaluation process. It also serves as an indispensable resource for meaningfully discussing the results of these tests as part of the patient education process.
Reviewer:Christopher James Hughes, PT,PhD,OCS,CSCS(Slippery Rock University)
Description:This primer on musculoskeletal imaging for physical therapists and physical therapy students is supplemented with a CD-ROM that contains over 200 images and additional information.
Purpose:The purpose is to provide physical therapists with a user friendly and easy to comprehend resource describing the role of imaging in clinical decision making. Given the expanding role of physical therapy practice, the book fulfills a need.
Audience:The primary audience includes physical therapy students and practicing physical therapists. Two of the authors teach in the division of physical therapy in the College of Health Sciences at the University of Kentucky and the third author is Associate Professor of Radiologic Sciences at Southern Illinois University.
Features:The book introduces procedures underlying the capture of musculoskeletal imaging, in particular basic plain film radiography. However, a section also covers other techniques such as ultrasound, computed tomography, and MRI. Images from MRI are displayed throughout. Coverage of major body regions defines each of the major chapters. In addition, there is a chapter on imaging of the brain and a chapter on long bone fractures. Crisp images, excellent line drawings, and tables provide information clearly and the writing is concise and appropriate for the audience. Case studies and clinical implications appear at the end of each chapter. The CD-ROM displays excellent images and effectively highlights pathologies in color. The book does not show patient positioning, but radiographs are of common views.
Assessment:This is a need to know reference to orient therapists to the role of imaging procedures. Although not as in depth as other books for this audience (i.e. Fundamentals of Musculoskeletal Imaging, 2nd edition, McKinnis (F.A. Davis, 2005)), it is a useful resource and offers nice clinical pearls to apply the information presented.


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Natalia Starr - Sweet blonde toyed and fucked
Description:Mesmerizing blonde takes out a toy after stripping and lets her intentions be known. Her muscular friend jumps right in to lick her pussy but also bang it hard from the rear.
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text:
Frantsuz Trailer (2004)
07 January 2004 Comedy, Romance 100 mins
A French baron Paul travels to Russia to find the woman whom he had been in correspondence. On arriving to a small Russian town he finds out that Ania had been helping his friend Irina to translate letters which Irina subsequently has been sending to Paul. At this New Year's Day love sparks in his heart as he tries to win her hand.
Watch the official Frantsuz 2004 trailer in HD below or find more Frantsuz videos on Vidimovie.


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The previous four winners were drawn low so THE KERNIGAL looks to have a fine chance of going one better than last time where he finished very strongly behind She's My Dandy only for the post to come just too soon. Sunrise Song, who was four lengths back in fourth, looks held while El McGlynn, who was close up in sixth, is drawn on the outside here. Echo Knight has been racing over further and has his first start on the surface and though Angels Art's run behind Wave here last month looks a decent effort she's hampered by the widest draw of all.
Angels Art (IRE) 12-1 (7-13) Mid-division, headway into 6th 2f out, ridden and no impression over 1f out, kept on same pace, 6th of 14, 4 1/2l behind Mr Red Clubs (9-0) at Dundalk 7f 2yo clm stks pol.
El Mcglynn (IRE) 33-1 (9-3) Rear of mid-division, kept on from over 1f out without threatening leaders, 6th of 13, 4 1/2l behind She's My Dandy (9-4) at Dundalk 6f 2yo hcp 50-75 pol in Oct.
Sunrise Song (IRE) 9-1 (8-9) Good speed on outer and soon led, strongly pressed and headed 2f out, no extra inside final furlong, 7th of 13, 4 1/2l behind She's My Dandy (9-4) at Dundalk 6f 2yo hcp 50-75 pol in Oct.
You Got Heart (IRE) 7-1 (9-0) Prominent, 2nd halfway, driven along early straight, no extra inside final furlong, 5th of 14, 6l behind Captain Cullen (8-12) at Dundalk 7f 2yo mdn auc stks pol in Oct.
Call Me Bubbles (FR) 50-1 (8-9) Chased leaders, 7th halfway, ridden and no extra entering straight, kept on one pace, 8th of 18, 18l behind Takar (9-0) at Leopardstown 7f 2yo mdn sft.
Ok Annie (IRE) 10-1 (8-2) Chased leaders, 6th halfway, ridden into 3rd 2f out, no extra in 5th 1f out, kept on same pace final furlong, 5th of 14, 4l behind Mr Red Clubs (9-0) at Dundalk 7f 2yo clm stks pol.
The Kernigal (IRE) 9-1 (8-9) Rear of mid-division, went 7th 2f out, kept on well inside final furlong, just failed, 2nd of 13, shd behind She's My Dandy (9-4) at Dundalk 6f 2yo hcp 50-75 pol in Oct.
Windsor Pride (IRE) 33-1 (9-0) Mid-division early, towards rear halfway, no impression after, 11th of 14, 23l behind Sambusca (9-0) at Naas 6f 2yo mdn in Oct.
Echo Knight (IRE) 25-1 (7-11) Led, strongly pressed entering straight, headed over 1f out, no extra inside final furlong, 4th of 14, 3 1/2l behind Coolnagree (9-0) at Leopardstown 7f 2yo hcp 50-80 in Oct.
Cultec Dot Ie (IRE) 20-1 (8-4) Mid-division, hampered after 1f, towards rear, ridden in 8th 2f out, stayed on into 3rd 1f out, no extra final furlong, 5th of 10, 5l behind Chocolate Hills (8-7) at Bellewstown 5f 2yo hcp 50-80 gd in Aug.
Banner Road (IRE) 66-1 (9-0) Led, strongly pressed and headed 2f out, no extra from over 1f out, weakened, 11th of 13, 16l behind Up (9-0) at Dundalk 1m 2yo mdn fll pol in Sep.
Charmingandpretty (IRE) 66-1 (8-12) Chased leaders on inner, 6th halfway, no impression from 2f out, 7th of 13, 13l behind Foot Soldier (9-0) at Roscommon 7f 2yo mdn sft in Sep.
Drinmoy Lad (IRE) 66-1 (9-3) Mid-division, 8th halfway, no threat from under 2f out, 10th of 14, 29l behind Indigo River (8-12) at Roscommon 7f 2yo mdn aut sft in Aug.
Red Laser (IRE) 50-1 (8-9) Rear of mid-division for most, never a factor, 13th of 18, 29l behind Takar (9-0) at Leopardstown 7f 2yo mdn sft.


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Go hard tonight, but save a minute of silence for the Thirsty Turtle, our wonderful namesake which closed down one year ago today.
The Thirsty Turtle opened in November 2007, replacing many businesses that had shuttered there in the past. Owing to an unusually large retail space in the notoriously poor business environment of College Park, businesses struggled to survive at the location in the past. Turtle was different.
They innovated. And they lived.
Within a matter of months, the Thirsty Turtle became known as an underage watering hole. While the bar officially carded all patrons, the standards were notoriously lax. Many students described the pitiful quality of the fake I.D.s they used to gain entry, and in September and October of 2010, undercover cadets of the University of Maryland Police Department successfully gained entry to the bars using their real, underage I.D.s
Beyond becoming the mecca of teenage euphoria, Turtle became a cultural touchstone of the University of Maryland. To this editor, it represented the face of a D1 party school, six months before transferring to UMD.
The Thirsty Turtle was forced to surrender its liquor license in November 2010, following a stabbing incident that involved several of its patrons. The political pressure the bar faced was insurmountable, and College Park lost yet another local business.
To them, it was a bar and a "problem." To us, it was home.
Long Live Turtle.
Yours truly,


text:
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George III mahogany triple pedestal dining table
c. 1780 England
Offered by Millington Adams
SoldRequest Information Call Dealer Favourite Item
A fine rare George III mahogany triple pedestal dining table of excellent colour and patina and of neat proportions able to seat up to 10 people. The well figured rectangular shaped top with rounded corners, made up of three sections, each with the ability to tilt and with its own pedestal base, the sections are held together with brass clips. Below each base section comprises of a tapering gun barrel column with ring turned relief, four swept sabre shaped legs terminating in brass caps and castors. Of particular note is the excellent colour, patina and grain (not depicted well here) of the superbly level and straight top. Good triple pedestal tables are rare and generally quite expensive, this is an excellent table and we are pleased to be able to offer it for sale.
Excellent. Old restorations, cleaning & waxing.
From a private residence in Wiltshire
English, George III; circa 1780
|27.50 inch
|(69.85 cm)
|105.00 inch
|(266.70 cm)
|51.00 inch
|(129.54 cm)
Stock Code1592
Millington Adams
Millington Adams
By appointment
+44 (0)1565 745012
+44 (0)7957 382381Favourite Dealer Request Dealer Alerts
Opening Hours
Open by appointment and at fairs
Marcus AdamsView Dealer Location


text:
I've recently bought JF just because of this integration, will give feedback once it has arrive and had enough time messing with it Hopefully there are no cases of "bricking" the stuff with firmware updates?...
hmm - the all caps warning doesn't put me off as much as the latter bit - the confusion about JF restarting, and THEN also restarting the synth? So 2x restart? Not precisely clear about that instruction.
i installed the beta last night. no problems whatsoever:
a few seconds after the firmware WAV finishes, JF flashes lights and returns to normal behaviour (some slow envelopes).
turn off the modular
unplug cable from sound source
unplug cable from JF
turn on modular
As I understand it it is not an instruction but a description: When the update is finished JF automatically switches to normal behavior ("restarting") then you switch off your case, disconnect your iPhone or whatever and restart the case...
Gooootcha. Good to know!
Hi @Galapagoose ,
I am sure this is on your radar, BUT, it would be great/important to hear from you directly on the issue of the potential JF ability to brick other modules via the -12V coimng out of the JF "RUN" input.
In this thread on Muffs:
some are already suggesting cutting traces and adding components on JF to "fix" this problem!
It seems that some first hand assessment of the situation from you, and perhaps suggestions on what to do, or not to do would help to clear the otherwise rising, murky waters of doubts/worries among the Jf owners.
I LOVE this module, and can't wait for the proper TT implementation release, but am feeling disheartened by the comments and reports coimng out from the users.
Very sincerely,p.
Just to be clear. I did understand what's to do, just gave my (personal) quick impression about the instructions after going through them.
Btw, is there a download link I missed?
Kudos this really looks amazing
Can't wait to try it out. Is the firmware/audio file link up somewhere? Will happily help beta test too if extra testers are needed
Please note the beta firmware is linked in the top post now. Please let me know any and all bug reports. The firmware is very close to a final version though I know there's a few small bugs and crash conditions to be worked out. Your feedback is much appreciated!
(Response to the somewhat OT 'RUN' jack issue forthcoming)
Thank you for all the work you've put into this and for making this amazing module even more interesting. This is very exciting!If I may ask, where can I find a link to the teletype firmware with support for Just Type?
Great modules all round from Mannequins. Still, this comment seems a bit cavalier and dismissive.
I don't believe it was intentional.
Crashes for me while moving intone knob in synthesis mode. I have to go back and forth with the knob but it always crashes eventually.also getting crashes with this script after 30 secs or so. mode transient -soundjf.mode 1jf.vox 1 n rrand 12 24 v 8adding another script cause the crash to happen faster.
No intention to be dismissive, I explicit meant I'm dealing with the issue! Just trying to keep this thread on topic.
Link above updated to include the teletype.hex file.
Been really delving this week with the original firmware; can't wait to try the new stuff tonight!
So far, fiddling with intone in jf.rmode crashes often for me.
I got to play w/ the update for a few hours last night. Seems to unlock tons of awesomeness!
I should have taken better notes, but a few issues off the top of my head
I also ran into the same issues in the synthesis mode where adjusting curve would lock up the device and emit a high pitch whine.
I had a confusing time updating the the run mode w/ teletype. Sending the unit JF.RMODE 1 didn't seem to have any effect nor did switching back to JF.RMODE 0. If I plugged a cable into Run I did seem to be able to adjust Run w/ JF.RUN X. But this adjustment wouldn't engage unless I plugged in a cable to the unit.
Something I was curious about, when the curve setting would lock the device in synthesis mode, my recollection is that teletype would also get locked, is that expected?
Regarding the upgrade, I didn't have any luck until I plugged in my laptop (a few attempts into trouble shooting), then it worked just fine
thanks for all the work on this!
Thank you! Everything went well with the update, used my mac's audio out, playing the file with VLC.
In terms of things to report, the main one is I no longer can use the USB stick I was using to load and copy teletype scenes. I was using a v1.21 firmware that @tehn had modified with some delay, though, so that explains why it's not working for me any more.
I got a few lockups of teletype when trying some of the JT commands in both synthesis/rhythms modes. JF.VOX tended to do that, though a few times it depended on the setting of the MODE switch (cycle seemed to lock things up a lot more often).
I'm also unsure what are the limits when setting voltage with JF.VTR. Not sure if some of the lockups might have happened because of me setting a certain voltage higher than what JF expects.
Will keep on exploring Just Type further today. Again, thank you very much for all of this!
First off, these new functions are awesome! There is a ton of potential in integrating the TT and JF. Really cool!! Thanks for all your work!
As far as issues go that I found. I also ran into the crashes in synth mode, lots of different scenarios. Faster clocks triggering JF.VOX did it and knob turns (seemingly any of them) would cause the crash/high pitch whine. Another thing I noticed which may be intentional??? Is that in plume mode the envelope response is different if you turn on the run mode digitally rather than with a dummy cable. I was able to get three different envelopes, the original (with a dummy cable only) which is quite short, a rather long attack and decay with JF.RMODE 1 and no dummy cable and then a third shape kind of in between the two with .RMODE on and a dummy cable inserted. I found this to be pretty useful.
Thanks for the reports! If you could please give a detailed description of mode settings & panel control positions, plus the TT commands you were sending at the time that would be the best help in terms of bug-fixing.
Regarding sending 'wrong' values, everything is clamped / scaled in JF so that shouldn't be the cause of the crash.


text:
From a female blog reader:
Good day, I have known this guy for over two years now, he is nice, gentle and makes sure he listens and attend to my needs. Right from the first four months of our relationship the guy has been singing about marraige but I didn't take him seriously because I don't mean to rush in following the disappointments i had from previous people. Now my problem is I visited this guy two days back and we had unprotected sex for the first time. This morning i saw him rubbing this kind of anti-inflammatory, fungus or bacterial cream(ketaconozole and another kind) on his penis which i know this creams are mostly used for treating genital infections, so I quickly took his phone and went through but i found nothing even though he can leave his phone with me for hours,Although I haven't felt anything abnormal or any itchy swelly signs but I was confused and mad at same time because i was wondering if he knew he has any STi nd still managed to go raw in me, could that be wickedness?? Family can a male contact a genital infection that was not sexually transmitted?? I know girls can from sharing inner garments nd usage of public toilets but i don't know of guys. I have been worried, we were supposed to travel out for vocation by weekend but I freaked out nd asked him to drop me at the airport because I'm leaving, nd I have not been talking to him since, he has been asking but i jus shun nd told him i dnt wanna go for the voc again. Family help me please. Thanks


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The protein encoded by KLF7 is a member of the Kruppel-like transcriptional regulator family. Additionally we are shipping KLF7 Antibodies (55) and KLF7 Kits (1) and many more products for this protein.
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In the spinal cord, klf7- and klf6a (show KLF6 Proteins)-expressing cells are found in both the dorsal and ventral horns. Numerous sensory structures (e.g. auditory, lateral line, olfactory and visual) and several motor nuclei (e.g. oculomotor, trigeminal, and vagal motor nuclei) contain klf7- and/or klf6a (show KLF6 Proteins)-expressing cells
Data revealed that expression of DNA binding inhibitor 3, early B cell factor 2, Ebf3, Iroquois related homeobox 1, Kruppel-like factor 7 , mab-21-like 1 , fatty acid binding protein 7 and stathmin-like 4,were enriched in the diencephalon of zebrafish.
Higher expression of TLR4 (show TLR4 Proteins) and KLF7 may play a vital role in the process of inflammation induced by obesity in visceral adipose tissue
a dominant mutation in FBXO38 (show FBXO38 Proteins) causes adult-onset, progressive spinal muscular atrophy with calf predominance
KLF7 was upregulated by morphine at both the transcriptional and the translational levels, promoting cell growth up to day 4
The gene encoding KLF7 is a novel candidate for conferring genetic susceptibility to type 2 diabetes.
KLF7 may contribute to the pathogenesis of type 2 diabetes through an impairment of insulin (show INS Proteins) biosynthesis and secretion in pancreatic beta-cells and a reduction of insulin (show INS Proteins) sensitivity in peripheral tissues.
We identified a novel association between the minor A-allele of KLF7 and protection against obesity in the Danish population
Data show that adult corticospinal tract (CST (show CORT Proteins)) neurons failed to up-regulate KLF7 in response to axon injury, and overexpression of VP16-KLF7 in vivo promoted both sprouting and regenerative axon growth in the CST (show CORT Proteins) of adult mice.
KLF7 inactivation in Klf7-null mice decreases the expression of the neurogenic marker brain lipid-binding protein/fatty acid-binding protein 7 (show FABP7 Proteins) (BLBP/FABP7 (show FABP7 Proteins)) in neural stem cells (NSCs).
Klf7 gene ablation reduces TrkA (show NTRK1 Proteins) expression in sensory neurons due to effect on cell death
Klf7 is important for neuronal morphogenesis in selected regions of the central nervous system.
Cooperation between Brn3a (show POU4F1 Proteins) and Klf7 is required for endogenous TrkA (show NTRK1 Proteins) gene expression and the survival of nociceptive sensory neurons.
Results advance knowledge of transcriptional regulation of olfactory neurogenesis and KLF7 action.
Upregulation of adiponectin (show ADIPOQ Proteins) protein by (-)-catechin may involve, at least in part, suppression of KLF7 in 3T3-L1 cells.
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants.
Kruppel-like factor 7 (ubiquitous)
, Krueppel-like factor 7
, ubiquitous Kruppel-like transcription factor


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1999 Toyota Camry - Consumer Review
Build Quality
Reliability Value
Build Quality
Reliability Value
Toyota Camry - A GREAT BUY
By Joel on
Vehicle1999 Toyota Camry LE 4dr Sedan
ReviewI've had my Camry approximately 3 1/2 years and it's the best car I've ever had. If you want reliability, its there. If you want extras, it's not bad. If you want comfort, it does the job pretty well. If you want performance, it can handle pretty well. For economy, it is pretty good. The value retension seems to be good. All around, this car is a pretty solid buy! I know what my next car will be. Another Toyota.
Best FeaturesI enjoy my sunroof. The window antenna is nice for car washes. The electric seating and stearing tilt are pretty good for driving comfort. The cup holders are definately a "nice clothes" saver.
Worst FeaturesThe steering wheel is a little cumberson when trying to see the RPM gauge. That could be changed. Seats could stand to be a little more soft.
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Neon Phone - WHITE/PINK (NP888-WP)
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Golden Eagle Electronics neon telephone Neon light flashes when phone rings Tone/pulse switchable Ringer hi/low/off Neon light hi/low/off Last number redial White base Pink neon bulb glows inside base
Size: 8.75"w x 2.5"h x 8.5"dShipping Weight: 3 lbs Shipping Cost: $8.00 ground shipping for Continental USA ♦ ♦ ♦
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Scpi consortium
A body established to promote Standard Commands for Programmable Instruments.
Address: 8380 Hercules Drive, Suite P3, La Mesa, CA 91942, USA.
SCPI in Europe (http://ourworld.compuserve.com/homepages/acea/scpi_uk.htm). Address: ACEA, P.O. Box 134, 7640 AC Wierden The Netherlands. Telephone: +31 546 577 994. E-mail: .
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1. senior chief petty officer. SCPO senior chief petty officer
- Scqf
abbreviation (in Scotland) 1. Scottish Credit and Qualifications Framework
Electronics. 1. silicon-controlled rectifier. 1. scruple. abbreviation 1. (in British universities) senior common room 2. silicon controlled rectifier abbreviation 1. scruple (unit of weight) SCR 1. Seychelles-rupee (currency) 2. skin conductance response 3. standard class rate 4. stripchart recorder 5. sustainable cell rate scr. scruple
- Scrabble
verb (used with object), scrabbled, scrabbling. 1. to scratch or scrape, as with the claws or hands. 2. to grapple or struggle with or as if with the claws or hands. 3. to scrawl; scribble. verb (used without object), scrabbled, scrabbling. 4. to scratch or dig frantically with the hands; claw (often followed by at): […]


text:
Ultraspin 10: My First Rave In Canada At The Koolhaus In Toronto
The first rave I attended by myself turned out quite amazing, it felt a bit weird going alone but I was so psyched to see my favorite DJ Yoji that it was worth it in the end.
Ultraspin 10 was the first rave I attended by myself because my friends just didn't like the main DJ of the event. It must have been one of the best sets I ever heard DJ Yoji spin.
The party was held at the Koolhaus (part of the Guvernemnt Nightclub Complex). Due to the shitty picture quality on my phone, UTstarcom PPC6700, I was limited to only take video and grab a bunch of pictures of my new friends after the party.
DJ Yoji's style and music are one-of-a-kind and will leave a serious imprint on the dance scene for years to come.
YOJI (formerly known as Yoji Biomehanika with aliases such as Mutant DJ, Ozaka Oz, Bionico and BIOMEHANIKA) is a popular Japanese trance/hard trance DJ.
Characterised by his striking clothing style, manner of entertaining behind and in front of the turntables, and being the driving force behind a style which he calls "Tech Dance", YOJI is one of the most popular Hard Dance DJs in the world. Although mainly creating music in solo productions, YOJI has frequently produced tracks in collaboration with Romeo Toscani in the form of remixes and 4 original tracks.
YOJI has made a big name as one of the icons of the underground electronic music scene, particularly in Europe after his gigs at big events including Sensation, Mystery Land and Dance Valley. His residency at GIGA in Japan has also given him a big following in his home country. YOJI has also played at events in the US, most recently at Southern California's Electric Daisy Carnival in front a crowd measured in the tens of thousands.


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Rishita Manhattan – ...
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Home buyers looking for a dream house equipped with all the amenities necessary for comfortable living at the desired location Migsun Ultimo is the destination they can invest in. Available in affordable price, Migsun Ultimo is situated at Greater Noida West and has 2BHK and 3HK apartments available in 1005 to 1575 sq ft.
Spreading over 6.50 acres of land, Migsun Ultimo has 6 towers and 21 floors that accumulate 1176 units of 2 and 3BHK apartments available in saleable area of 1005 sq ft to 1575 sq ft. Its price and the features that it has to offer make Migsun Ultimo an ultimate choice amongst the buyers. Following are few of its salient features that increase its prospects:
· 3 side open plot
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· 10000 sq ft club house
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· International PGA standard 18 hole golf course nearby
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text:
Swimmer's ear is an ear infection localized in your outer ear canal, and is one of the most common problems among swimmers (hence the name!).
According to the MayoClinic,
Free download: 7 Tips to Remove Earwax at Home
"Acute external otitis or otitis externa… is often brought on by water that remains in your ear after swimming, creating a moist environment that aids bacterial growth."
Of course, it's not ONLY caused by swimming, but can be the result of inserting anything into your ear.
But how can you tell if your ear infection or ear ache is actually swimmer's ear and not some other problem? In this article, we'll look at how to diagnose the problem and what to do for swimmers ear.
We'll not only give you the options of medical treatment for swimmers ear, but you'll learn a few swimmers ear home remedies as well. By the end of this page, you'll know everything you need to about dealing with the problem!
Note: To learn more about what swimmer's ear is and swimmer's ear prevention, read this post What is Swimmer's Ear and What are the Symptoms?
How to Diagnose Swimmers Ear
Before you undergo swimmers ear treatment, don't you want to be certain you're treating for the right thing? How can you be certain that it's actually swimmer's ear and not some other infection?
Thankfully, diagnosing the problem is fairly simple for your ear doctor!
When you visit your doctor, they'll start out by asking you a few questions. They may ask about your recent activity, any symptoms you're experiencing, if you've inserted anything into your ear, etc.
A simple physical examination will usually be enough to determine if it's swimmer's ear or some other type of infection.
The physical exam will include:
- Ear canal exam using an otoscope. This instrument shines a light into your ear, helping the doctor to see if the ear canal is scaly, swollen, red, or filled with debris or flakes of skin – all signs that you have swimmer's ear.
- Ear drum visualization, or taking a closer look at your ear using the otoscope. Your doctor wants to be certain the ear drum isn't damaged or torn.
These two tests will usually be enough for the doctor to render a diagnosis.
However, the doctor may recommend further evaluations according to the stage of your swimmer's ear or the severity of the infection.
This may include:
- Taking a sample. This usually only happens if the infection doesn't respond to the treatment. This is done to detect the exact bacteria causing the infection, making it easier to treat that specific problem.
- Referral to an ENT. An ear, nose, and throat specialist will be called in if the eardrum is torn or damaged, and they will examine your middle ear for any signs of infection. This is because the treatments used to deal with outer ear canal infections are different from those for the middle ear canal.
Thankfully, these last two are rarely used, as swimmer's ear tends to be a fairly simple, easy-to-deal-with sort of infection!
But now that you know how swimmer's ear is diagnosed, it's time to move on to the next step: how to treat swimmer's ear…
How to Treat Swimmer's Ear
According to WebMD,
"Swimmer's ear is usually not a dangerous condition and often clears up within a few days after starting treatment."
What a relief! It's a condition that is easily treated, using a number of different options:
Medical Treatment for Swimmers Ear
The best way to deal with the problem: visit your doctor! Once you undergo an exam to ensure it's swimmer's ear, the doctor may recommend one of the following treatments:
Ear cleaning
The doctor will usually give your ear canal a gentle cleaning, using either a suction device or cotton-tipped probe. This cleaning will eliminate most of the debris and flaking skin, essentially removing the bacteria's food source.This will help to reduce the pain and irritation of the infection.
Note: Oto-Tip is a safe, effective way to clean your ears at home. The soft-tipped device will remove wax efficiently, eliminating debris and flaking skin!
The most commonly recommended medications for your swimmer's ear are:
- Naproxen (Aleve)
- Ibuprofen (Advil and Motrin)
- Acetaminophen (Tylenol)
These are all OTC medications, and they will usually help to reduce the pain of the infection.
Note: If the infection is severe, a stronger antibiotic will usually be administered.
Ear Drops
This is the most common medical treatment for swimmer's ear, and the most effective. The prescribed eardrops contain a combination of:
- Acidic solution, to balance your ear canal's pH and fight off the bacteria
- Antibiotic, to fight off the bacterial infection
- Steroid, to reduce the swelling
Note: If the infection is caused by fungi rather than bacteria, the ear drops will contain antifungal medication.
The ear drops are easily applied, and they can help to deal with the problem effectively. You can ask someone to apply the drops for you, or apply them yourself at home.
Of course, if your ear canal is VERY swollen or there is a discharge of fluid, the ear drops may not be as effective on their own. The doctor will usually insert a "wick" made of gauze or cotton, and apply the drops to the wick.
The liquid will seep down, treating the infection effectively!
Swimmers Ear Home Remedies
Of course, if you don't want to go the route of doctors and medications, you can always try to handle the problem at home. There are many home remedies that can help you clear up the infection easily.
Here are a few swimmers ear home remedies you can try:
Using vinegar for swimmers ear can help to dry out the infected area and stop bacterial and fungal growth.
To apply vinegar, simply mix it with rubbing alcohol and pour a few drops into the ear. It can be a bit painful, but it works!
Hydrogen Peroxide
For those who want to know how to treat swimmer's ear with peroxide, it's as simple as pouring a few drops into your ear.
The hydrogen peroxide will help to reduce the infection and kill off the bacteria.
Warm Compress
Place something warm next to your ear, and the heat will help to reduce the pain and discomfort of the infection.
Here are a few more tips for preventing and treating swimmer's ear:
- Keep your ears dry after a shower. Use cotton balls with Vaseline (on the outside) to stop water from getting into your ears and making the infection worse.
- Avoid using cotton swabs, no matter how bad the itching gets!
- Leave your hearing aid out until the swelling has gone down and the discharge stops. The same goes for headphones and ear plugs.
- Don't fly until the infection clears up. Swimming and scuba diving are also no-nos!
It's important that you understand that these home remedies are a simple alternative to medication. They're not the most effective option, so it may be best to visit your doctor for proper treatment.
Sometimes, it's better to take the medication (ear drops or antibiotics) than go the natural route!
Possible Complications
Swimmer's ear is a fairly minor problem, but, if left untreated, can become a serious problem!
According to WebMD,
"If untreated, it can become extremely and surprisingly painful. In rare cases, especially in diabetes patients or anyone with problems with their immune system, the infection may be more difficult to treat and can spread and damage underlying bones and cartilage, requiring hospitalization."
Yikes! The last thing you want is for the bacterial infection to spread to the cartilage and tissue in your bones! So close to your brain…
Thankfully, treating swimmer's ear is fairly simple, so you should have no problem using the medication, medicated ear drops, and home remedies to deal with the infection.
The infection will clear up in a few days (if treated properly), and there will be no permanent damage to your ear drum, ear canal, or hearing. Phew!


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It Runs in the Family (1994)
The Old Man: Women! You can't live with 'em - and you can't live with 'em!
Ralph as an Adult: The Old Man was having the time of his life being miserable. It was what he did best.
Ralph 'Ralphie' Parker: [over a badly distorted P.A] ... This is J. Edgar Hoover... Junior!
Randy Parker: I wanna go on the rides, I wanna go on the rides, I wanna go on the rides.
The Old Man: You'll just get sick again.
Randy Parker: I wanna get sick, I wanna get sick, I wanna get sick.
Mrs. Parker: Ralphie you are going to get it!
Ralph 'Ralphie' Parker: What did I do?
Mrs. Parker: Don't give me that you tied Randy's feet together!
Ralph 'Ralphie' Parker: Well he put his turtle in my oatmeal


text:
I learned last night that the Salsa Gordo has been discontinued. I emailed Salsa and they replied that they're phasing out rims so they can really dial in their other parts and accessories to reflect the brand's direction, Adventure By Bike...
Sorry, but isn't the wheel like the most important part of a bike?? How does this make any sense?
I searched high and low all over the internet for two sets of 32 hole Gordos and couldn't find any. Man... That was one of my favorite rims.
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Thread: Salsa Rims


text: Hi, I am using Droid X with Android 2.2 1) I recently installed couple of apps from getjar.com, but I don't see any options to update those Do I need to keep track of the updates myself? 2) I created a folder and have lots of apps shortcut, but once the folder is big enough, I can scroll but it jerks and background becomes dark, any1 else facing this problem? Thanks!!


text:
Learning to think.
A Poem to my Mind. Breaking the Spell.
Infernal Mind you have put me under your spell.
Your intoxicating fumes ceaselessly excoriate me.
Your spell has me down on my knees.
I am your disciple in bonded servitude.
As your devotee I pay homage.
Yet you are never placated.
I ask myself:
Why do I believe you?
I believe your false promises of heaven!
Yet hell is my bed!
Mind, from this day forward,
I break the spell.
Mind, from this day forward,
You are not my master.
Mind, from this day forward,
I pay homage to myself.
Mind, from this day forward,
I lay flowers at the altar of myself.
Mind, from this day forward,
You are my servant.
Mind, from this day forward,
Your thoughts have nothing to do with me.
Mind, from this day forward,
I renounce you as I renounce all illusions as real.
Tarot 1 Intensive
Course ongoing at the moment but if you are interested let me know and Le Urban Retreat will host another course.
New Testimonial
I just completed a session with Terryann and experienced the deep healing of her work on my self and family. Each time her work penetrates more deeply and provides a more profound healing and awareness. I feel totally blessed that she is in my life and I have had these opportunities to heal through her experience, knowledge and eternal support. My deepest gratitude and love for your being. – Helen Babalos
Free yourself from your convictions.


text:
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The SAGA complex provides a paradigm for multi-subunit histone modifying complexes. Although first characterized as a histone acetyltransferase, due to the Gcn5 subunit, SAGA is now known to contain a second activity, a histone deubiqutinase, as well as subunits important for interactions with transcriptional activators and the general transcription machinery. The functions of SAGA in transcriptional activation are well-established in S. cerevisiae. Recent studies in S. pombe, Drosophila, and mammalian systems reveal that SAGA also has important roles in transcript elongation, the regulation of protein stability, and telomere maintenance. These functions are essential for normal embryo development in flies and mice, and mutations or altered expression of SAGA subunits correlate with neurological disease and aggressive cancers in humans.
Histone modifications, such as acetylation and ubiquitination, play a key role in facilitating a number of cellular events, including gene regulation. Acetylation of histones is largely associated with relaxing chromatin structure to support the entry of transcriptional machinery to genomic loci for activation, while histone ubiquitination has been linked to both gene activation and repression [1, 2]. The histone modifying enzymes that catalyze these post-translational modifications are often integrated into large multi-subunit complexes to facilitate their enzymatic activity and substrate specificity. SAGA (Spt-Ada-Gcn5 acetyltransferase) is a 2MDa multi-protein chromatin modifying complex that is conserved between yeast and humans and harbors two known enzymatic modules that mediate the acetylation and deubiquitination of histones as well as non-histone substrates [3-5]. However, like many multi-subunit complexes, the functions of several components in the SAGA complex are still unknown. In addition, it is unclear exactly how the members of SAGA interact, coordinate and regulate the acetyltransferase and deubiquitinase activites of the complex, and whether the acetyltransferase and deubiquitinase (Dub) modules function in a cooperative or antagonistic manner to regulate cellular processes, such as gene regulation. Here we will discuss the most recent advances made toward deciphering how the catalytic activities of the SAGA complex function in development and disease.
The Tetrahymena thermophila protein, p55, was the first identified transcription related histone acetyltransferase (HAT) enzyme and is the ortholog of the yeast (y) transcriptional co-activator protein, Gcn5 (general control nonderepressible 5) [1]. Recombinant yGcn5 acetylates non-nucleosomal histone 3 (H3) lysine residue 14 (K14) [6, 7]. However, the incorporation of yGcn5 into native multi-subunit complexes, such as ySAGA, expands its specificity to additional lysines in nucleosomal histones in vitro, including H3 K9, 14, 18, 23 and to a lesser degree histone H2B [7, 8].
The ySAGA complex is modular in structure and has distinct functional units (Table 1) including a recruitment module (Tra1) [9, 10]; acetylation module (Gcn5, Ada2, Ada3) [11-14]; TBP interaction unit (Spt3, Spt8) [13, 15, 16]; Dub module (Ubp8, Sus1, Sgf11 and Sgf73) [17-21]; and architecture unit (Spt7, Spt20, Ada1, TAF5, -6, -9 and -12) [8, 13, 22, 23]. ySAGA is recruited to gene loci by the interaction of Tra1 with specific transcriptional activators [10], and the bromodomain of yGcn5 binds acetylated H3 and H4 N-terminal tails which potentiates cooperative nucleosome acetylation of histone H3 [24, 25] (Figure 1A). The HAT module composed of yGcn5, yAda2 and yAda3 catalyzes this acetylation, opening up the chromatin landscape for binding of additional transcription factors and the pre-initiation complex (PIC) [14]. The ySpt3 subunit of ySAGA also recruits TBP to facilitate PIC formation and transcriptional activation (Figure 1B) [16]. In addition to promoting gene activation, a modified ySAGA complex, lacking ySpt8, accompanies Pol II during elongation and functions to acetylate and subsequently evict nucleosomes from gene coding regions (Figure 1 C, D) [26]. The Dub module of ySAGA, including Ubp8, Sus1 and Sgf11, also facilitates elongation through deubiquitination of H2B K123ub1 (Figure 1C), which allows for the recruitment of the Ctk1 kinase and subsequent Ser2 phosophorylation of the Pol II C-terminal domain (Figure 1D) [27]. ySAGA contributes to other aspects of gene expression as well. For example, SAGA-mediated histone acetylation functions in co-transcriptional spliceosome assembly and the recruitment of U2 snRNP to intron branchpoints [28], and SAGA-associated Sgf73 and Sus1 proteins link histone deubiquitination to the mRNA export machinery [29].
The components, modules and functions of the ySAGA are highly conserved across many species and act as a model for understanding the Drosophila (d) and human (h) SAGA complexes. The remainder of our discussion will focus on the enzymatic modules of these metazoan SAGA complexes and how their regulation is intimately linked to both development and disease.
Although the general compositions of dSAGA and hSAGA complexes are very similar to the ySAGA complex, some differences have been observed. The GCN5 transcript is alternatively spliced in mouse and human cells, generating a short (GCN5S) isoform similar to yGcn5, and more predominantly expressed long (GCN5L) protein isoform that is incorporated into hSAGA and is highly analogous to the GCN5-related family member, PCAF [30, 31]. This long GCN5 isoform is also conserved in Drosophila Gcn5 (dGcn5), suggesting an evolutionary gain of function in ancestral metazoans [32]. GCN5L (hereafter referred to as GCN5) contains both a HAT domain and a bromodomain similar to yGcn5, but also has an extended N-terminal domain which confers the ability to acetylate mononucleosomal H3 as well as free H3 in vitro [30, 33]. Metazoans also have two proteins similar to yAda2, ADA2A and ADA2B, which are found in distinct GCN5-containing complexes [33-36]. In particular, ADA2B is present in hSAGA and serves to bridge the interactions between GCN5 and ADA3 to facilitate acetylation of chromatin substrates [33]. Interestingly, both ADA2B and ADA3 may regulate distinct aspects of chromatin acetylation, as ADA2B-GCN5 dimeric complexes enhance the ability of GCN5 to acetylate mononucleosomes, whereas acetylation of polynucleosomes is strictly mediated by ADA2B-GCN5-ADA3 heterotrimeric complexes in vitro [33]. dAda2b and dAda3 also likely regulate some aspect of chromatin acetylation in vivo, as deletion of either dAda2b or dAda3 leads to decreased H3 K9, 14 acetylation levels on polytene chromosomes [37, 38]. Furthermore, loss of Wda (a yTAF5 homolog) in Drosophila also reduces H3 K9 acetylation levels without compromising the integrity of the dSAGA complex, suggesting a role for Wda in chromatin acetylation [39]. Post-translational modifications identified on these and other subunits [40], as well as the acetylation of hADA3 by GCN5 [33], imply that PTMs may also play an important but unexplored role in regulating the functions of SAGA, including HAT activity.
As in yeast, hSAGA is recruited to specific target genes by activators, such as c-Myc, p53 and E2F, to stimulate the acetylation of histones and the activation of transcription [41-45].
While gene expression profiling for GCN5 has yet to be reported in mammalian cells, experiments in both budding (S. cerevisiae) and fission (S. pombe) yeast support the idea that GCN5 is a gene-specific co-activator, as yGcn5 only appears to regulate 4% and 1.1% of genes, respectively [46, 47]. However, numerous genome–wide mapping studies of histone acetylation patterns demonstrate that yGcn5 globally acetylates H3 K9, 14 and that Gcn5 binds within the promoter and 5' coding regions of most highly transcribed genes in S. cerevisiae [48-52]. Additionally, genome-wide analysis of yGcn5 in S. pombe indicates that Gcn5 may have a general role in elongation, given that yGcn5 is found within the coding region of actively transcribed genes, and correlates with high H3 K14 acetylation levels [53]. Interestingly, hSAGA contains at least three subunits that have the ability to bind histone tails, including SGF29 which harbors a chromodomain, hSTAF65γ that displays a BTP domain (bromodomain transcription factors and PHD containing), and hADA2B that has a SANT domain (DNA binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB). A role for these subunits in SAGA recruitment has not been reported; however, global Gcn5 mediated acetylation may be modulated by such domains. Collectively, these studies indicate that hSAGA functions both in gene specific and in global transcription events and that it can act at multiple steps in the transcription cycle.
Although first discovered and characterized as a HAT complex, SAGA was later discovered to harbor a second catalytic module centered on the Ubp8 (yeast) or USP22 (metazoan) deubiquitinases. As with GCN5, the Dub subunit may work most efficiently in the context of a module within SAGA that contains additional components [29]. In yeast, Sus1, Sgf11, and Ubp8 form a structural entity within the ySAGA holoenzyme, and the association of this Dub module with the rest of the complex is mediated by Sgf73 [29]. Sgf11 does not have a substantial role in maintaining the overall composition or integrity of SAGA but appears to mediate either recruitment or stable association of Ubp8 in ySAGA [20, 54]. Sus1 is present in two functionally different protein complexes in both yeast and in flies, the SAGA complex where it regulates its deubiquitination activity through interactions with Ubp8 and Sgf11 and the TREX/AMEX complex, where it plays a role in mRNA export [55-57]. Such dual functions of E(y) 2 (the Drosophila ortholog of Sus1) have implicated dSAGA in the positioning of specific gene loci (like hsp70) to the nuclear periphery, achieving a tightly regulated link between transcription and mRNA export under stress conditions [56]. hUSP22 deubiquitinates H2Bub, like the yeast ortholog, but can also deubiquitinate H2A in vitro , implicating its function in the regulation of Polycomb-mediated H2A ubiquitination [58, 59].
Polyglutamine (polyQ) expansions in the N-terminal region of ATXN7 (the mammalian ortholog of Sgf73) are associated with spinocerebellar ataxia type 7 (SCA7), which is characterized both by motor coordination deficiencies (ataxia) and retinal defects. Mouse models of SCA7 indicate that both the wild type and mutant forms of ATXN7 integrate into the SAGA complex and do not affect SAGA composition. However the effects of polyQ ATXN7 on SAGA HAT activity or on SAGA-mediated gene activation are not clear. In one set of experiments, the acetyltransferase activity of the complex did not appear to be affected by transgenic polyQ ATXN7, even though chromatin immunoprecipitation experiments indicated aberrant SAGA recruitment and hyperacetylation of H3 K9, 14 on rod cell-specific gene promoters in the retinas of the transgenic mice. Surprisingly these hyperacetylation events correlated with decreased mRNA levels of the analyzed genes [60]. In contrast, two other studies which used either cultured cells or yeast expressing the polyQ forms of ATXN7/Sgf73 came to very different conclusions on the effects of the mutant protein on SAGA functions [61, 62]. Reduced levels of acetylated H3 were observed on promoter-enhancer regions of photoreceptor genes, likely caused by impaired acetyltransferase activity of the complex in the presence of the polyQ expanded form of ATXN7 [62]. Neither of these studies addressed the effects of the polyQ allele on the Dub module. Clearly, much more work is needed to understand how the polyQ expansion affects SAGA recruitment and enzymatic activities.
Given that SAGA is conserved across many species and plays an essential role in regulating gene expression, it is perhaps not surprising that particular subunits of the SAGA HAT module control developmental processes. In Drosophila, loss of dGcn5 is lethal due to a lack of metamorphosis[63]. Furthermore, dAda2b and dAda3, which regulate H3 K9, 14 acetyaltion are also essential for Drosophila viability. In a similar manner, Gcn5 is required for normal development in mice. Gcn5 null (Gcn5-/-) mice are embryonic lethal at 10.5 days post coitum (d.p.c.) and do not acquire normal mesoderm due to enhanced apoptosis in these tissues [64]. However, catalytically inactive Gcn5 mice survive slightly longer (16.5 d.p.c.) and display both neural tube closure defects and exencephaly, implying that Gcn5 HAT activity is required for proper development and that SAGA also has HAT-independent functions [65]. Interestingly, PCAF null mice develop normally, but double homozygous null Gcn5 and PCAF embryos die at 7.5 d.p.c. indicating a functional redundancy for these two HATs during embryonic development [64, 66]. In cell culture, Gcn5 -/- mouse embryonic stem cells remain pluripotent and are capable of differentiation into all three germ layers [67]. The role of GCN5 in ES cells has yet to be defined, but is of considerable interest. H3 K56ac is linked to pluripotency of human embryonic stem cells and GCN5 acetylates H3 K56 on free histone in vitro, suggesting that GCN5 may play a role in maintaining stemness [68, 69].
In addition to the HAT module regulating larval and embryonic development, the SAGA Dub module has been identified to control different aspects of neural development. This is observed by mutations in the Drosophila nonstop (USP22 ortholog) and dSgf11 proteins leading to defects in axonal targeting photoreceptors [70, 71]. Furthermore, retinal defects are also observed in the SCA7 neurodegenerative disease as discussed above, but the roles of USP22 or other Dub module subunits in development have not yet been defined.
The role of hSAGA in cancer is a good paradigm of its multi-functionality. For example, TRRAP and GCN5 regulate the oncogenic activity of the c-Myc oncoprotein and the p53 tumor suppressor [41]. Additional studies underscore that the whole SAGA complex may function in tumorigenesis. STAF65γ (hSPT7) has a role in the transcription of several Myc-dependent genes [43]. Furthermore, SAGA recruitment may require SGF29, a poorly studied subunit of the complex, whose deregulated expression is implicated in malignant transformation [72]. In parallel, GCN5/PCAF acetylates non–histone proteins involved in transcriptional activation or repression, such as c-Myc [73].
The deubiquitination activity of the hSAGA complex has also been implicated in cancer, as USP22 has been grouped by transcriptional profiling into an 11-gene "signature" of poor prognosis in multiple types of cancer [59, 74]. This signature also includes the PRC1 polycomb repressor complex subunit, Bmi1, a known regulator of self renewal in normal and malignant stem cells, suggesting USP22 may be a marker for cancer stem cells. Specifically, USP22 may be required for cell-cycle progression and could function with GCN5 to control certain cell cycle genes. GCN5 has been implicated in the transcriptional regulation of cyclin A, cyclin D3, PCNA and cdc25b, as well as CDK1 and cyclin B1 after DNA damage [75]. Furthermore, GCN5 acetylates the non-histone protein CDC6 to promote S-phase progression of the cell cycle. GCN5 and USP22 also protect telomeres from DNA damage response through the stabilization of a shelterin component called TRF1, and interestingly, this regulation is not transcriptional but involves USP22-mediated deubiquitination of TRF1 [76]. In addition, the Gcn5 related protein, PCAF, appears to regulate ubiquitination of Hdm2 through an intrinsic ubiquitination activity [77] and chk2 turnover [78], adding another level of regulation to an already complicated network.
SAGA is comprised of distinct modules that intimately collaborate to maintain structural integrity, genomic recruitment and interactions with the basal transcription machinery to localize the HAT and Dub activities of the complex to gene loci. Elegantly, SAGA mediates histone acetylation of gene promoters to enhance transcriptional activation and facilitates elongation by deubiquitinating histones downstream of Pol II and acetylating histones within the coding region to promote histone eviction (Figure 1). Functional HAT and Dub modules of the SAGA complex are central to normal mouse and Drosophila development. In addition, SAGA functions in cancer, as USP22 is part of an 11 gene "signature" associated with poor cancer prognosis and SAGA contributes to the activation of c-Myc responsive genes. However, many questions remain unanswered regarding the intricate regulation of this co-activator complex. Do SAGA components outside of the HAT and Dub modules either stimulate or suppress these enzymatic activities (Figure 1A)? What role do posttranslational modifications of the SAGA components play in complex regulation (Figure 1B)? Is SAGA-mediated histone acetylation required for Dub activity downstream of Pol II (Figure 1C), and do members of the HAT and Dub modules cross regulate each other (Figure 1C, D)? In addition to these questions, much remains to be elucidated about the biological function of SAGA. Little is known about the role of USP22 in mammalian development or the function of GCN5 and/or USP22 in embryonic stem cells. Furthermore, it is unclear how tightly the functions of GCN5 and USP22 are linked or whether the HAT and/or Dub module functions in SCA7 disease. Addressing these questions will undoubtedly lead to a clearer understanding for the roles of SAGA in development and disease.
We thank Boyko Atanassov, Yi Chun Chen, Andria Schibler and Marenda Wilson-Pham for useful comments and discussions on the manuscript. Calley L. Hirsch is funded as an Odyssey Fellow supported by the Odyssey Program and the Houston Endowment Inc, Award for Scientific Achievement at The Univeristy of Texas M.D. Anderson Cancer Center. Parts of this work were supported by a grant from the NIH to SYRD, GM067718.
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Evangelia Koutelou, Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Calley L. Hirsch, Program in Genes and Development, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Sharon Y.R. Dent, Center for Cancer Epigenetics, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Margaret Hugeback
|Let the memory of Margaret be with us forever
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Ched Evans rape trial: Footie ace claims pal asked him to 'join in' for threesome
FOOTBALLER Ched Evans was asked to "join in" to have sex with his alleged victim by his footie pal, a court heard.
The Chesterfield striker appeared at Cardiff Crown Court charged with raping a 19-year-old girl at a Premier Inn.
Evans, 27, told the court of the encounter, claiming the victim was "enjoying herself" with former teammate Clayton McDonald.
The court heard how Evans let himself into the hotel room at the Premier Inn near Rhyl, Wales, after collecting the key from the reception.
Giving evidence, he told the jury how he walked into the room and was asked by McDonald to join in — claiming that the woman agreed to it.
The defendant said: "When I saw them, she was asking Clayton to f*** her harder.
"When I walked in, the door slammed and they both looked at me.
"Then Clayton looked at her and said: 'Can my mate join in?' She looked at me and said yes."
Evans revealed how he and McDonald – who was previously acquitted of rape – had been involved in another threesome after a game of strip poker "about two years before".
In this case, the court heard how Evans got undressed in the hotel room before performing oral sex on the alleged victim.
He said: "She was making noises like she was enjoying herself."
The court heard Evans and the complainant then started having sexual intercourse.
He added: "It was like a natural progression — it just happened.
"I can only describe that she was enjoying herself."
"When I saw them, she was asking Clayton to f*** her harder"Ched Evans
The footie star told the jury he stopped having sex when he realised he was cheating on his girlfriend.
He said the woman told him to "f*** me harder" and added "she moved into different positions".
McDonald went to the bathroom to get dressed, saying "I am getting off lad".
Evans said he then stopped having sex and "the situation became real — I was cheating on my girlfriend".
He said: "I pulled away. She grabbed the quilt and pulled it over herself and huffed. I started getting dressed."
Evans denied "sneaking" out of the hotel and said he used the fire exit because he wanted to walk directly to the road outside.
Ms Khan asked Evans "Is there any doubt in your mind she was consenting?"
Evans replied: "No."
She then asked "Did she appear to be too drunk consent?" to which Evans also replied "no".
Finally she said "did you rape (the complainant)?", and Evans once again said "no".
CCTV played to the court showed the alleged victim fall over in a kebab shop the night before the alleged offence.
A "drunk" Evans was also in the shop with mates after a night out drinking bourbon.
But he told jurors: "Was I aware of her when I was in the kebab shop? No. Did I see her fall? No".
Evans is accused of raping the girl who was too drunk to consent.
He denies the charge.
The trial continues.


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Stock Graphic >> Illustration - Cocktail Vintage Hand-drawn Style 255734 by mollyliai @ CreativeMarket
File Size: 3.58 MB; Layered: Yes; Vector: Yes.
Cocktails in vintage style hand-drawn on wooden boards. Text is outlined and not editable by typing letters on the keyboard and located on separate layer. Every cocktail is located on a separate file.
Handcrafted with love and attention to every detail.
- 10 Cocktails hand-drawn include Ai file
- 100% Vector
- Editable and resizable
- Text is editable ( not editable some titles "Summer", this is not font )
- Includes two color versions
You can also look to my collections
- Summer Holiday Hand-drawn Collection: https://creativemarket.com/mollyliai/255733-Summer-holiday-Hand-drawn-collection
If you want to give feedback or have a questions, I will always be happy to help. With love from mousemade design - Enjoy!
Keywords: hand drawn, drink, glasses, sunshine, sun, menu, blue, sky, summer, happy hour, party, mojito, elements, symbol, lettering, logo, bundle, design, retro, holiday.


text: Health The 5 Best Healthy Food Trends Of 2017 by Protima Tiwary March 20, 2017 Yay everyone's jumped on to the healthy living bandwagon! We're so glad people are taking their health seriously. Be it eating clean or training mean, everyone's living a healthy life,… 0 Facebook Twitter Google + Pinterest


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Life with acne can be unpredictable, frustrating and embarrassing. For those who struggle with on-again, off-again moderate to extremely severe acne, it can be a struggle to eat right, moisturize right and even cover up blemishes the right way to keep breakouts at bay. To understand how to best deal with oily and acne-prone skin and select makeup products like foundation, we asked Rosalyn George, MD and Sandra Johnson, MD, both board-certified dermatologists, for their expert advice.
"Finding the right foundation that doesn't feel greasy or make them break out more can be difficult for those with oily or acne-prone skin," explains Dr. Johnson. "Generally, if your foundation isn't formulated for your skin type, it could clog your pores and worsen acne."
While most makeup products won't necessarily indicate the skin type it's best suited for, Dr. George recommends looking for "clues" on the label. For the safest bet, look for the terms "hypoallergenic," "oil-free" and "non-comedogenic" on the label as these products tend to work better on problematic skin, as are mineral-based loose powder formulas.
Here are some other tips on how to apply your foundation if you have oily or acne-prone skin:
Ready to try out new foundations formulated specifically for oily or acne-prone skin? Check out our favorites below.
For a mineral-based powder designed for oily skin types, consider this five-star rated foundation. "I love this foundation and the coverage: GREAT for super oily acne prone skin," writes one Dermstore reviewer.
Mineral based? Check. Oil-free? Check. Plus, it contains SPF 20-25 to help you fight against the sun's harmful UVA and UVB rays.
An anti-aging foundation that's formulated for oily and acne-prone skin, this foundation delivers full coverage while fighting fine lines, wrinkles and breakouts. Also delivers a matte, non-greasy finish.
A foundation and skin care product hybrid, its moisturizing formula helps to reduce the appearance of uneven skin from acne and aging.
Acne-prone skin can also be susceptible to scarring and redness, which this foundation aims to combat, along with premature aging and loss of skin elasticity.
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"This foundation is great! It has cleared my skin and I now have minimal clogged pores on my face," writes one Dermstore shopper of this five-star-rated, vegan foundation with SPF 20 to 25 coverage.


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5 Ingredient Fix: Easy, Elegant, and Irresistible Recipes
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- Synopsis
- The quest for simple, affordable, and fresh, mouthwatering food is over. 5 INGREDIENT FIX helps put delicious and sophisticated meals on the table in a snap. With people struggling to simplify, streamline, and budget, the Food Network's Claire Robinson is here to help. Cooking doesn't have to be complicated to be impressive; simplifying the process with fewer ingredients saves time, frustration, and ultimately, money. From breakfast treats like Brioche French Toast with Strawberries and Cream to no-fuss meals like Grown-up Grilled Cheese and Iceberg Wedges with Buttermilk Dressing to a romantic dinner of Grilled Scallops with Saffron Aioli and Green Goddess Rice, all of Robinson's recipes have five or fewer ingredients. A quick trip to the supermarket for one bag of groceries, and a delicious, restaurant-quality meal can be on the table in no time.
- Copyright:
- 2010
Book Details
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- Publisher Quality
- 9781455500000
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- Grand Central Life & Style
- Date of Addition:
- 10/06/10
- Copyrighted By:
- Claire Robinson
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- Nonfiction, Cooking, Food and Wine
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What You Should See and Do in Austin on Your Vacation
Austin is one of the most unique cities in the United States. It is a city known for being "weird" and for its unconventional vibe. Visitors will enjoy countless activities that no other city can offer in a laid-back and casual atmosphere. It is an inexpensive city to visit and Austin, TX vacation lodging is very easy to find. Make sure you book Austin, TX lodging with a pool in the summer. Here are some of the things the city's visitors cannot miss and will not be able to experience in any other place.
Get in Touch with Nature
This city is definitely a city for lovers of the outdoors. The city's inhabitants walk and bike everywhere and the city is very health-oriented. There are numerous biking and hiking trails, as well as lakes and springs. You cannot miss taking a swim on Barton Springs Pool, which is a spring-fed swimming hole that is 68 degrees year round. Visitors can relax and float around the pool. It is a very popular spot in the summer and is filled with young residents and visitors. If you would like to rent a boat and spend an afternoon in a lake, Lady Bird Lake and Lake Travis are perfect for some outdoor enjoyment.
Eat From a Food Truck
The city is known for its unique food truck eating experience. It is filled with hundreds of food trucks that offer a great variety of food ranging from Korean barbeque to Greek gyros. Most food trucks are located in the downtown area of the city. There are also many events in which visitors can enjoy live music while enjoying trailer food.
Take In Unparalleled Nightlife
This city boasts one of the best nightlife scenes in the world. The city has a very young population due to its hip atmosphere and the heavy student population from the University of Texas. As a result, there are hundreds of bars, coffee shops, and live music venues. The best place to experience the Austin nightlife is the Sixth Street District area. You will find dozens of unique hole in the wall bars filled with Austin hipsters.
Catch Some Live Music
The Capital of Texas is known as the live music capital of the country. There is literally live music everywhere. You will find yourself enjoying local bands in places you would have never imagined, like the airport or a grocery store. Take some time to listen to some local bands play live and experience music in true Texas style.
Although it seems like the Capital of Texas is a hustling and bustling city, it is also a great place to relax and get some rest. There are dozens of top-rated spas and golf courses. Find Austin, TX lodging with a pool and enjoy the warm Texas weather soaking in the sun. There are also some world-class golf courses throughout the city. You will also be able to find Austin, TX vacation lodging and resorts that have golf courses.
Do Some Shopping
As if you did not already have enough things to do in this city, there is another activity that you cannot miss – shopping. The city is known as a premiere shopping destination for hipsters around the country. The downtown/university area is lined with local boutiques that offer items that range from vintage clothing to high-end designer brands. Don't leave without visiting The Domain. It is a very impressive outdoor shopping center with stores like Barneys, Burberry, and Gap.
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The author has an immense knowledge on Austin, TX lodging with a pool. Know more about Austin, TX vacation lodging related info in his website.
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Legal Question in Family Law in District of Columbia
I got divorce in the state of Georgia and one the requirements are for boths parents to attend a parenting class before finalization. Only one of attended this class since we both have copies of the decree,signed is it legal or can one contest it.
Asked on 2/23/10, 7:12 am
1 Answer from Attorneys
Michael Hendrickson Law Office Michael E. Hendrickson
Then why did the one who now wants to contest it sign the decree in the
first place?
Answered on 2/28/10, 8:40 am


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Uses of Variance and Lower Partial Moment Measures for Portfolio Optimization
Portfolio optimization is mainly a multi-objective optimization problem that aims to maximize expected return while minimizing risk. It is important to define the meaning of these parameters accurately, in terms of validity that is acquired by the solution of the problem. In this study, portfolio optimization is implemented through two downside risk measures, semi-variance and lower partial moment, which are stated by researchers to be better representation for investors risk perception. Genetic algorithms, which are among the heuristic computational methods, are used to achieve pareto-efficient portfolios. The implementation is tested by historical data of the shares that are authorized to Istanbul Stock Exchange (ISE) 100 Index, and it is observed that the efficient portfolios achieved by the implementation are consistent with expected results.
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Volume (Year): 4 (2010)
Issue (Month): 1 ()
Pages: 47-73
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