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A LORRY driver who was told he would have to leave Britain within 10-days because he was born in America, is to receive a full apology from the Home Office. On April 1, father-of-four Terry Morris received a letter from the Home Office telling him he had to leave the country, despite living in Wales for 55 of his 56 years.
At first he though it was an April Fool's Day joke, but it soon dawned on him that the letter was entirely serious.
Mr Morris's father Frank was an American GI who married his mother, Olive, in Cardiff in 1945.
The family moved to the US and Terry was born in Kentucky, but the family returned to live in Cardiff when he was just 11-months-old.
When Mr Morris applied for a passport it led the Home Office to send him an ultimatum telling him he would have to leave his family home in Wales.
But the Home Office has now apologised for the error and a formal written apology was sent to him last night.
A Home Office spokeswoman said, "We are very sorry for the stress that has been caused to Mr Morris.
"The original decision has been withdrawn and Mr Morris's application for indefinite leave to remain will be granted and his status normalised. He will be informed in writing.
"The decision was not in accordance with current instructions.
"We are very sorry in this case, but will take action and reissue guidance to ensure this sort of thing doesn't happen in future."
Mr Morris and his family were last night celebrating the Home Office U-turn.
"It's great news," he said. "When I see the letter in my hands then I will really believe it.
"They have apologised, that's something - I never expected an apology."
Mr Morris said that the normalisation of his status, that the Home Office was now offering, would "put the icing on the cake".
But the three days since the letter arrived had not been easy for Mr Morris and his wife Anne.
"We didn't get much sleep, we lost 4lb in weight each," he said.
"It was stressful, but I think I knew that deep down at the end of the day the cavalry would come and I would not be going anywhere, but I am still finding it hard to believe."
Mr Morris has received massive support from friends, family and other people, amazed at the letter from the immigration bureaucrats.
When his status is settled Terry will finally be able to look forward to a foreign holiday.
"If I get my passport I will make a point of going abroad - just to seal the deal!"


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- Location
- Main Contact
Key products/services
Distributed to thousands of professionals, buyers and brands, the SOURCE Sustainable Buying & Sourcing Guides are your key to buying and sourcing responsibly.
Are you a buyer? Find brands to stock in your shop.
Are you press? Discover the most exciting sustainable fashion.
Looking for suppliers? We bring you over 80 pioneering sustainable suppliers, manufacturers and sourcing experts.
The fourth annual printed SOURCE Directories are now in circulation. You can purchase printed copies here or download the online PDF versions for free by filling out this short form here.
Secure your space in the next edition of the SOURCE Sustainable Buying & Sourcing Guides by joining SOURCE today
About the Guides
Now in their fourth year, the printed SOURCE Sustainable Buying and Sourcing Guides are the definitive resources for sustainable buying and sourcing. The Sustainable Buying Guide makes it easy for buyers to find the latest innovative sustainable fashion brands and the Sustainable Sourcing Guide puts socially and environmentally conscious suppliers at the fingertips of designers.
Each guide gives a snapshot of the sustainable businesses listed on the SOURCE Database – the most extensive ethical sourcing and business database for the fashion sector. All listed businesses are SOURCE Members and have been reviewed against the SOURCE Ethical Mandate.
Where are they Circulated?
- Distributed at all SOURCE events and leading industry partner events throughout the year, including Pure London, London Fashion Week, Clothes Show Live and SOURCE Summit, just to name a few.
- Posted to key buyers, brands, retailers, press and influential industry players.
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Ethical Focus & Policy
All SOURCE members listed in the printed directories, must comply with our Ethical Mandate. Find out what this includes.

subset: commoncrawl


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Our Message: You Can Solve Your Problems & Change Your Life by Escaping America for a Better Life and Love Overseas! Discover Friendlier Foreign Women, Authentic People and Saner Cultures, Lower Cost Living, Healthier Food, Greater Freedoms and More!
Why do girls bleach their hair?
Discuss and talk about any general topic.
Moderators: jamesbond, fschmidt
5 posts • Page 1 of 1
Why do girls bleach their hair?
Why do girls bleach their hair to appear blonde? It's even popular in countries like Russia. Why do they want to appear blonde? It's not like they can permanently change their hair color. It seems like a waste and like they're trying to commit a fraud to get a man. The bleached blonde hair combined with eyebrows which have their natural hair color create a weird look. Can't they tell that men will realize its bleached? Why not just keep their hair natural instead of bleaching it blonde? I wouldn't ever date a girl that bleached her hair. Even women in their 30s and 40s do it so its not just girls in their teens or 20s.
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in all honesty I have no idea. It gets on my nerves too because it looks cheap and crappy in my opinion. Then the over processing completely fries your hair. I've seen lots of older women and teens do it here in America and I am like way to destroy the health of your hair.
I don't know if any of you knew this, but Debbie Harry (of the band Blondie), is actually a brunette w/ regular brown hair. She'd been bleaching, her whole adult life for her music career.
And this is her iconic look ...
She clearly doesn't look like some stereotypical blonde bimbo like Marilyn. So the smart brunette playing a blonde, seems to work here.
16 years ago, the Best Picture of 1999, "American Beauty", telegraphed the message of Happier Abroad to the world.
Beware of long term engagements with AWs, you may find yourself in a coffin.
AB discussion thread
BTW, despite settling down with an AW, myself, the warning is still in effect.
Everyone wants to be more beautiful, and the global media promotes blonde as beautiful. It's the same reason why some people might bleach their skin, hit the gym, and so on.
There are also some people that just want to try a new style too (although that is often just used as an excuse, I do believe that some people do it for "fun" or to try it out).
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Velocity inlet condition.
Is it possible to provide velocity inlet data for a simulation from the data taken from another simulation? If so, can someone please tell me how. Both the simulations are being run in Fluent and the mesh size is the same for both.
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I want a lead to identify and generate new business with clients.
1) Identify new clients and understand their needs related to our business.
2) Generate new business with the clients identified
3) Arrange business discussion meetings with the clients
4) Project finalization and contract negotiation for the projects finalized with clients per company's guidelines
Our company is based in Bangalore, India. I am looking for a lead who can work from India and outside India but is capable of generating business within the region located.
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I read all your requirements and I have developed many similar websites like yours I will Provide Services Until You get 100% satisfied. I'm not just looking for money OR one project, as I firmly believe in long term เพิ่มเติม


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by John
(Killeen, TX)
I'm currently 15- 20000 dollars in debt and looking for a financial miracle. I've been in debt for a long time now and have been struggling from paycheck to paycheck and I'm looking for a huge financial blessing. I'm thankful to have a job but it seems like I'm just paying for bills and barely making it. I'd like to be able to take my family out and go to dinner and go to see a movie or just go shopping. Please pray with me and come to an agreement with me that God will release a financial miracle into me n my families life.
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Johannesburg: Team India coach Greg Chappell spoke to select Indian publications (including The Telegraph) on Tuesday afternoon. The interaction lasted almost 90 minutes.
The following are excerpts:
On whether the decision to bat at the Wanderers was something which came easy to Rahul Dravid
It wasnt easy... But, then, you lose a big advantage (in Tests) if you dont choose to bat after winning the toss... Rahul made a courageous decision.
On the most crucial partnership
The one between Rahul and Sachin Tendulkar, which added 69 for the third-wicket in the first innings. If theyd gone early, we may not even have scored 100. Lets face it, the wicket wasnt easy.
On what the 123-run victory holds for the rest of the series
Its a big confidence booster... (After a pause) Where our ODI performances are concerned, the truth is somewhere between the extremes our excellent run at the start of the year and the recent losses. However, its amazing what confidence can do and what a lack of confidence does.
On whether the ODI defeats affected the process he has been trying to put in place
Definitely slowed down the discussions...
On team spirit remaining high despite the 0-4 rout in the ODIs
Thats the best thing and it happened in the West Indies as well, when we came back to win the Test series after the 1-4 loss. In Pakistan, too, we won the ODIs after being defeated in a hard-fought Test series... What Ive seen is that the Indians (by nature) are resilient.
On the seniors beginning to play a bigger role off the field as well
For a team to be good, a strong leadership group is required... We had a meeting in Potchefstroom where it was decided that, from then on, things had to come from within the group... The coaching staff had done what it could do and, now, it was time for the leadership group to take over... The players had a meeting where the coaching staff wasnt present and they understood the need to get better and stronger... Rahul involved the seniors (in a bigger way) as its not possible for one man to do everything. The responsibility of captaining, including the emotional side, had become too much... The workload, the mentoring... It had to be shared... Obviously, the win there was important, but that in itself wasnt the turning point.
On having a leadership group
It certainly is an Australian thing, but wasnt as well defined (within Team India) as it is now. For example, the key moments in a game have to be grasped out on the field by the leadership group. One needs leadership across the team: Among the seniors, at the middle level and among the juniors.
On whether Virender Sehwag, who was vice-captain till the ODIs, didnt discharge responsibilities
It wasnt that... But even two cant do the job, you need four-five seniors... (After a pause) I dont know why he lost the vice-captaincy and I dont have a comment.
On Indias pace attack delivering at the Wanderers despite being short on experience
Weve been asking the boys to do a mans job... Sree did it, but it will be tough to do it again (soon). The physical and emotional strain on him was huge. Backing up day after day isnt easy, more so as the grounding hasnt been there in domestic cricket.
On MoM Sreesanth
Always knew he had the ability... Wed been impressing on him that pace isnt the most important thing... Consistency is important, not bowling magic balls... That its all about how consistently youre able to land the ball in the right areas... Srees seam position was perfect and came out beautifully... I havent seen anybody do that with the same degree of consistency... He managed it six times in an over... You wont be successful if youre looking to (aggressively) take a wicket on every ball... Good batsmen are able to handle pace, what they cant is variety... Good bowlers work out the length they need to bowl and Sree was superb. Munaf (Patel) learnt it quickly in the West Indies...
On Sreesanths interaction with the legendary Allan Donald before play on the second day
The beauty is that Donald talked about the thought process rather than the physical process. Its all very well to understand mechanics, but the engine of the mechanics is the brain and, really, the thought process drives the mechanics. What Sree understood is that he had to bowl one good ball after another.
On Sourav Gangulys comeback
He has always been a strong character and his will and desire to play for India has been second to none... At one team meeting, Sourav revealed that the realisation that cricket wasnt everything in life had taken the pressure off him... If you think that every innings is (all) important, then you wont bat with freedom... Sourav, I think, is more relaxed now.
On whether the victory at the Wanderers has given him a fresh perspective on ODIs
(Laughs as the question coincided with his taking time to have water) Cant say why it took me time! Were always reviewing the situation and its about getting the best team... The demands (of ODIs) are different... So , what works for the Test team doesnt necessarily work for the one-day team... The win has given us options to think about, but theres time... Realistically, we should look to make the World Cup semi-finals... From then on, any team may win. When the teams land in the West Indies, even the best wont be guaranteed to take the Cup home.
On whether he would be willing to compromise in the ODIs
Youve got to be prepared to compromise at all stages in life... Runs made is more important than runs saved on the field, but theres a balance thats non-negotiable... Were trying to get that balance right... Im not the only one involved with selection, there are six others.... Im definitely going to place my views strongly, but at the end of the day, Im just the coach and have to work with the team thats given to me. Im happy doing that... I wont stand on a philosophical argument which doesnt give us the best chance of winning the World Cup.
On how he reacts to criticism
Same as everyone else... Dont enjoy it any more than anybody else does... But worrying wont help... There are certain things that I understand are important, but I cant expect everybody else to (a) agree with them or (b) understand them... (After a pause) It depends where the criticism comes from... Im more likely to take note of critical comments from some...
On the emotions he went through when the team kept losing ODIs
I was frustrated, dejected... All the emotions came to the fore, but the reality had to be faced and work had to be done... Occasionally, shuffling the deck chairs on the Titanic is what youve got to do... I recall there were days as captain when I didnt have a clue left. If you show that, though, then youre gone as that emotional state is contagious. As coach, I cant display that publicly... Throwing the baby out with the bath water wasnt an option as, within reason, we had pretty much the best group.
On whether his personality intimidates some players
Thats why, in the coaching and support staff, nobody has the same personality... There are times when I get (biomechanist) Ian Frazer to convey a message, for Im the wrong person to do so... Ian and I have different personalities, but dont think differently and I know he wont convey mixed messages... Our masseur (Ramesh Mane) is a key member of the support staff as players often come to him when theyre down... He massages their minds, too, and does convey messages of course, not like a secret agent! Fact is some relate to me better than others. Equally, I relate better to some... Some players can take a strong message and deal with it, others cant... Thats the way it is...
Finally, on what have recent weeks taught him the most
That certain issues needed to be addressed and its good we had to do it now rather than closer to the World Cup. It will stand us in good stead.


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Kanye West- Welcome To Heartbreak Ft. Kid Cudi
- Kid Cudi is gonna kill almost everybody this year
- Kanye West is GREAT and noone can tell me anything other than that!
- No this video isn't messed up thats the way they made it.
Common- Punk Drunk Love Ft. Kanye West
Off of Common's new CD out December 9th!!!! annnddd if you gooo to commons website Thinkcommon.com on December 9th only u can buy his whole cd for 99 Cents!! no joke!
enjoy this one! produced by The Neptunes
808s & Heartbreak & Theater Of The Mind
come out next monday the 24th.. im not sayin you have to go get them both but ive heard a good majority of both and they are gonna be great!!!
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Home heating oil price hike could add £92 to bills
Householders in Northern Ireland are being advised to stock up on home heating oil "sooner rather than later" as prices are expected to rise in the coming weeks.
Industry experts issued the warning following a 23% hike in just one month, after the cost of a litre of oil rose from 31.05p in September to 38.25p in October.
BoilerJuice boss Ian Ronald said it represented the steepest monthly heating oil increase since the winter of 2010, making it the third biggest price increase on record.
If rises continue, it will be enough to add a hefty £92 to average annual bills for local householders in three-bedroom semi-detached properties.
The bad news will hit consumers hard as temperatures continue to fall, and it also comes at a time when fuel prices have been soaring in recent weeks.
Speaking to the Belfast Telegraph, Mr Ronald said that Northern Ireland's 400,000 households currently using home heating oil continue to be impacted by fluctuations - and he urged consumers to act immediately.
"Speculation on OPEC oil production cuts was a key factor in why heating oil suppliers have increased their prices of late," he said.
"With another meeting of the oil producers cartel taking place later this month, there's a chance that further speculation continues to impact heating oil prices."
He added: "We recommend checking your tank sooner rather than later.
"Considering that heating oil prices increased sharply around the last OPEC meeting, it is reasonable to assume that prices could increase further before the next meeting takes place on November 30."
On September 22, for example, 900 litres of oil cost £279.45, compared to £339.84 today. That's a difference of £60.39.
Meanwhile, on that same day 500 litres were priced at £155.25, which is £33.55 less than it would set you back at today's rate of £188.80. Figures obtained by the Belfast Telegraph from BoilerJuice, the independent heating oil website, show that from April 2015 to March 2016 the average household across the province ordered heating oil 2.2 times per year.
The average number of litres ordered here was 621, which equates to 1,366 litres each year for a Northern Ireland home.
Using the price per litre on September 22, the cost of 1,366 litres was £424.14, but that same amount of oil would today set you back £515.80 - an increase of £91.66.
Mr Ronald said that between September and October the price of crude increased by 8.5%, including a one-year high of $53.29 per barrel on October 10.
"This is widely believed to be the most significant factor affecting heating oil prices," he said.
"We do recognise times are uncertain for heating oil users, but whilst the recent price rise has been dramatic, heating oil still represents the cheapest form of energy available after historic price lows earlier in 2016."
Prices have soared recently due to a number of world events.
That included the weakened value of sterling following the EU referendum result, and speculation that many major oil producers, in particular Russia, were open to striking a deal with OPEC to reduce oil output.
Michael Toner, who runs price comparison website cheapestoil.co.uk, said recent price rises have been due to the weakening pound against the dollar.
Belfast Telegraph


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Chaminade Resort & Spa
Select your stay dates to check availability
Chaminade Resort & Spa
About the hotel
Property Location
With a stay at Chaminade Resort & Spa in Santa Cruz, you'll be by the ocean and convenient to DeLaveaga Golf Course and Mystery Spot. This 4-star resort is within close proximity of Sante Adairius Rustic Ales and Pasatiempo Golf Course.
Make yourself at home in one of the 156 air-conditioned guestrooms. Cable programming along with video-game consoles are provided for your entertainment. Bathrooms feature shower/tub combinations, designer toiletries, and hair dryers. Conveniences include phones, as well as safes and desks.
Rec, Spa, Premium Amenities
Pamper yourself with a visit to the spa, which offers massages, body treatments, and facials. If you're looking for recreational opportunities, you'll find a health club, an outdoor pool, and a spa tub. Additional amenities include gift shops/newsstands, wedding services, and a picnic area.
Enjoy a meal at a restaurant, or stay in and take advantage of the resort's room service (during limited hours). Relax with your favorite drink at a bar/lounge or a poolside bar.
Business, Other Amenities
Featured amenities include a business center, express check-in, and express check-out. Event facilities at this resort consist of conference space and meeting rooms. Free valet parking is available onsite.
Hotel Facilities
- Business center
- Tennis on site
- Health club
- Steam room
- Dry cleaning/laundry service
- Multilingual staff
- Spa treatment room(s)
- Porter/bellhop
- Gift shops or newsstand
- ATM/banking
- Bar/lounge
- Spa services on site
- Meeting rooms
- Restaurant
- Full-service spa
- Number of floors - 2
- Picnic area
- Express check-in
- Wedding services
- 24-hour front desk
- Free valet parking
- Conference space
- Smoke-free property
- Total number of rooms - 156
- Poolside bar
- Express check-out
- Sauna
- Spa tub
- Elevator/lift
- Safe-deposit box at front desk
- Breakfast available (surcharge)
- Outdoor pool
Room Facilities
- Premium bedding
- In-room massage available
- Free newspaper
- Designer toiletries
- Rollaway/extra beds available
- Bathrobes
- Room service (limited hours)
- Refrigerator (on request)
- Hair dryer
- Pay movies
- Premium TV channels
- Coffee/tea maker
- Climate control
- Video-game console
- Desk
- Microwave (on request)
- Access via exterior corridors
- Iron/ironing board
- In-room safe
- Air conditioning
- Shower/tub combination
- Phone
- Cribs/infant beds available
- Cable TV service
- Daily housekeeping
Hotel Policy
Know Before You Go
- Reservations are required for massage services and spa treatments. Reservations can be made by contacting the resort prior to arrival, using the contact information on the booking confirmation.
The following fees and deposits are charged by the property at time of service, check-in, or check-out.
- Pet fee: USD 150.00 per pet, per stay
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
Mandatory Fees and Taxes
You'll be asked to pay the following charges at the hotel:
- Resort fee: USD 30.00 per accommodation, per night
- Pool access
- Spa access
- Fitness center access
- Internet access
- Self parking
- Parking
- Housekeeping/cleaning fees/gratuities
We have included all charges provided to us by the property. However, charges can vary, for example, based on length of stay or the room you book.Show all hotel policy Show less hotel policy


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If you feel like a light and healthy meal have a plate of hummus with assorted vegetables. I like the fact that hummus can be used in may different dishes so I am sure to make enough to last the week. I also make many different varieties which I will post about later. This hummus is just a simple plain hummus seasoned with salt, pepper, lemon juice,tahini and paprika.
Sometimes I eat this dish with pita chips or toast points but today I just had it with vegetables and it was very filling.


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This is another painting for my show in mid-October. I got a little crazy with this one. This neon bowling pin is located in Salt Lake on State street around 23rd south (not the exact address, but you certainly aren't going to miss it!)
The cows are in their retro bowling shirts and are ready to bowl. Bowlin' anyone?


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FATHERStarting with the Father, it is the Father who begat the Son. The Son is not made, He is begotten before all worlds/ages - that is - this begatting is outside of time, He is (not was) eternally begotten. If there is one way to describe the God the Father, it is actually one word - charity (or love). God IS love. The Father loves the Son.
SONThe eternally begotten Son of the Father loves the Father too, for also being God, the Son IS love. The Son shows His love for the Father in doing whatever the Father asks of Him. No questions, no excuses - just love.
HOLY GHOSTThe Holy Ghost proceeds from the Father, through the Son. Since the Father and the Son are both One, the Holy Ghost proceeds from the Son as well as the Father. There is one love which comes from God and we receive that love through the Holy Ghost, for the Holy Ghost also being God, IS love.
The Holy Ghost is also the maternal - as in our mothers. When it comes to the good and well-being of her children, every good mother would do everything in her power to keep her children safe. The same is true of the Holy Ghost who will be there for the children of God and provide the means necessary for their salvation.
WHAT IS LOVE?Well, God is love - we've already stated that. How is that love expressed? The love of the father for his children is shown in him being there, not just for their physical needs - but spiritual as well. Matthew 7:9-10 and Luke 11:11 say it well. It goes both ways too - if the son loves the father, he not only will DO what the father asks of him, he also won't just say things he thinks the father wants to hear for is that really love?
OTHER VERSES TO PONDERJust hover over these verses and/or click on them to read them:
Matthew 7:21
Luke 6:46
Romans 2:13
Feel free to add your thoughts to the comments section, or hey - if you're one of MY children and have more to share - call me! I promise, if you ask for bread, I will not give you a stone.


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Browse market data tables and in-depth TOC of the Engineering Software Market to 2025 @ http://www.theinsightpartners.com/reports/engineering-software-market\nRequest Sample Copy @ http://www.theinsightpartners.com/sample/TIPTE100000135\n
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No of Pages: 150
Publishing Date: Nov 2016
Single User PDF: US$ 3900
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Engineering software are used in design or manufacturing automation across a number of different engineering disciplines such as electrical engineering, electronics and communication engineering, process engineering, mechanical engineering, and chemical engineering among others. Despite steady growth in the past few years, the global engineering software market is expected grow considerably during the forecast period, expanding its use in various application areas and untapped opportunities.
A significant reduction in time and cost can be achieved in the product development cycle with the introduction of engineering software such as CAD, CAM, CAE, and EDA among others. Also, engineering software provide easy accessibility to the users, thus reducing extra efforts and increasing efficiency and work quality, thereby driving its adoption. The engineering software market is further flourishing due to the rising adoption of portable computing devices at workplace coupled with easy availability of these software over cloud. Rising need of automation in process industries (such as oil & gas, manufacturing and offshoring industries among others) is expected to create new opportunities for the global engineering software market during the forecasted period.
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The lack of skilled personnel to develop and operate applications on engineering software hinders the global engineering software market. This eventually limits the number of users, thereby reducing the sales volume of engineering software. In addition, high license fees of the engineering software products makes it inaccessible for small & medium enterprises (SMEs), thus impacting the global engineering software market to an extent. High maintenance cost of the engineering software products leads to piracy which further restricts the global engineering software market.
The global engineering software market has been segmented on the basis of software type into computer-aided designing (CAD) software, computer-aided manufacturing (CAM) software, computer-aided engineering (CAE) software, architecture, engineering & construction (AEC) software, and electronic design automation (EDA) software. The global engineering software market has been further segmented by applications into Plant Design, Design Automation, Drafting & 3D Modeling, Product Design & Testing, Others (Enterprise Resource Planning, etc.).
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On the basis of geography, the global engineering software market is divided into North America, Europe, Asia Pacific (APAC), Middle East & Africa (MEA) and South America (SAM). APAC region specially, China, India and South Korea, being the major contributor to global software technology, are expected to have seamless opportunities in field of automation promising substantial growth of the global engineering software market over the forecast period. North America with high adoption of engineering software, especially cloud-based, leads the global engineering software market and is expected to continue its dominance over the forecast period. A similar trend is expected within Europe region, owing to a high adoption of cloud-based solutions and services. The key players in the global engineering software market are looking forward to tap market potential across the oil & gas industry in the Middle East region, by providing system automation.
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Some of the key players in the global engineering software market include Microsoft Corporation, Google Inc., Oracle Corporation, IBM Corporation, Rockwell Automation, Inc., Honeywell International, Inc., NemetschekVectorworks, Inc., Seimens AG, Aspen Technology, Inc., Cypress Semiconductor Corporation, Aveva Group Plc, Integraph Corporation (Hexagon AB), DassaultSystemes, KBC Advanced Technologies Plc, Schneider Electric, Cranes Software International Ltd., Autodesk, Inc., SAP SE, PTC, Inc., Corel Technology Pvt. Ltd , D'GIPRO Design Automation Pvt. Ltd., and SmartDraw LLC among others.
The report provides qualitative and qualitative insights about growth rates, key market shares and factors driving the market drivers for all segments. The report highlights the growth rates and market sizes of various segment and highlights the sections expected to experience high growth rate in various geographic segments. The report also consist of company profiles of the market leaders and various players in the Engineering Software Market. These company profiles include product portfolios, market developments, financial performances and SWOT analysis for each company. The report also offers a competitive landscape of the Engineering Software Market.
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Contact Us : +1-646-491-9876| E-Mail : [email protected]
Contact Us : +1-646-491-9876| E-Mail : [email protected]
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it's an internet thing!
it's an internet thing!
10:32 12 December 2011
Peaches Geldof is set to marry her rockstar boyfriend, Thomas Cohen, after revealing they have kept their engagement a secret for six months.
The 22-year-old has been dating Cohen for a year, but says the wedding will not be for a couple of years, telling the Sunday Mirror:
"Yes, I'm engaged! We don't want to get married for a couple of years yet though so don't expect me in a dress yet. I'm so happy!"
The couple have just bought a three bedroom Victorian house together and are set to move in in January.
She told the newspaper that since becoming engaged, she has started to settle down and leave her partying days behind saying:
"Im actually really boring. Recently, Ive been staying in with my fiancé every night of the week, watching films like Babe."
Despite her young age this will be the socialites second wedding, after she married Max Drummey in 2008 - just one month after they met.
They eloped in Las Vegas but their marriage ended six months later. When she announced her divorce from Drummey she said:
"I didn't go into it with Max thinking, 'This is going to last forever'.
"But I did go into it thinking, 'I love him right now and I know that I will continue to love him for a long while.'"
The daughter of Bob Geldof met 20-year-old indie rock band singer Cohen in January and the pair have seemed inseparable ever since.
Disclaimer: Supanet is not responsible for, and disclaims any and all liability for the content of comments written by contributors to this website


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I actually do not believe my good luck. I bundled the baby up and went for a walk yesterday in the freezing weather. Got to the end of the alley that runs down the back of the terrace houses where we live, and just sat there looking lost and lonely was a chair. Not just any chair but a beautiful Ercol Armchair. Could not believe it. I actually had to do a double take. It was just dumped outside what I was pretty sure is an empty house at the minute. Immediately I hatched a plan to rescue it. Obviously I was not carrying that thing anywhere with a baby in tow, and I wanted to check the house was really empty so I waited patiently until OH got home and sent him out on a mission (he's used to my weird ways).
He went to knock on the door first, at a time when anyone living there should be back from work and had a peer in the un-curtained windows. No-one living there. Result! Chair grabbed and rescued from the bin men and now sat in my kitchen drying out. It's not got a seat cushion but I figure I can make one and I'll just have normal cushions for the back so that you can see the amazing shape. It's in excellent condition still with all the mud cleaned off. It can't have been used much or sat out in the rain too long. It did still have the padded armrest pieces attached but I've removed them too (they pop off easily as they're just attached with big press-studs). The joy of it is the clean lines and beautiful construction, not the hideous, dated floral fabric. I'm so happy I could do a little happy dance. It even matches the lovely dining table and chairs I have that a special friend gave me. The wood is slightly darker and needs a bit of a touch up but they'll look great together.
(I did try to take a good photo but we have the wettest, gloomiest day ever today so that's not happening.)
(I did try to take a good photo but we have the wettest, gloomiest day ever today so that's not happening.)


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Who is Shy Glizzy? What is net worth of Shy Glizzy? Shy Glizzy is an American hip hop artist. He started rapping at the age of 13 and is often compared to the likes of Lil Boosie Eazy-E. He has released several mixtapes since 2011, including Law, Law 2, Young Jefe and Law 3: Now or Never. His debut mixtape was called No Brainer. According to Shy Glizzy he had a rough childhood which is somehow is reflected upon his several of his lyrics.
Shy Glizzy's hard life in the streets of DC often comes up in his songs. Though very young, he has had fair share of problem with the law, and has been incarnated prior to becoming a rapper. He holds the vulnerable belief that rappers should be truthful about where they come from and what they've done there.
Rapper Shy Glizzy was born in Washington, D.C, in May 1993. He grew up with his mother, grandmother and his younger brother who also raps under the name 3 Glizzy. His father was murdered while he was only 19. During his early 20's he started a group called Glizzy Gang and his known for his solo album Young Jefe as well as the hit song "Awwsome" from the album. Glizzy gang is a group which includes rappers 'Plies', 'Ant', 'Snipe', '3', and 'Quette'. The group has released numerous song together, very few of them have released their own singles.
Shy is better known by his stage name Jefe which he changed at the close of 2016. In 2012, Jefe released his mixtape Law in addition to Fxck Rap and ATL rapper Trinidad James appears on the track "Pilot." The Fader describes Fxck Rap as "an appealingly" eager tape. At the age 14, he was arrested for petty larceny and spent his high school years in and out of juvenile detention. There he started reading the Koran, then daily newspaper, stacks of biography and after all these he started writing rap lyrics.
He never graduated high school and managed to obtain his GED while in prison. According to public records he faced some serious charges of drug possession, gun possession and theft. By the end 2011 he started taking music more seriously. Shy Glizzy issued the Young Jefe mixtape, which not only produced his first big hit with the slurring and infectious but also hint at a future name change of the rapper. A remix of "Awwsome" peaked in the Top 50 of the Billboard R&B/Hip-Hop Songs Chart. Some of his notables tracks are called "3Milli," "Stoner Freestyle," "No Lie," and Guns & Roses."
Shy Glizzy Net Worth
Shy Glizzy net worth is estimated around $0.7 million US dollars as of 2017. He also gets paid through sponsorship, ads, featuring, and so on. In year 2015-16 his earning through album/songs was around $127,000. These albums include Streets Hottest Youngin, Law, Fly Money, Fxck Rap, Law 2, and Young Jefe. Apart from these earning he earns significant amount of money through endorsements. His latest tape Be Careful is quite successful. But he has also some troubles as he was accused of disorderly conduct in Montgomery Country that somehow affects his earnings and career. At present he is a star with a good amount of money at just an age of 24.
Shy Glizzy Assets
Shy love for gold can be seen through $50,000 gold chain which was lost during a performance. There was a rumor that Shy Glizzy planning to buy his first vintage car but still there is no authentic news from the sources. At present he lives in a house with his mother in Washington D.C.
He is just 24 and started his career back in 2011, since then he achieved a lot in the field of music. In 2013 he was nominated for O Music Awards in Make a Band Famous Category. In 2015, he was chosen as part of XXL Magazine Freshman Class. Billboard placed his song "Awwsome" at No.30 in hip-hop airplay chart.
In starting of the year 2017 Shy released "One" from a new EP titled "The World is Yours" and there he decided to change his name to Jefe.
Shy is Kanye-level superstar himself. He is an unsigned artist but showed his talent with his single "Awwsome" song and put on some remarkable shows. His charisma is radioactive; the dance floor turns into a trampoline. His most of the time is spent in studios, improvising lyrics behind a microphone, finding new way to narrate his life. In short he is a fully loaded package.


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The 2016 Annual Wage & Benefit Survey is a joint project of the affiliated organizations of Printing Industries of America. It was conducted in the summer of 2016 and the effective reporting date was June 1, 2016. This year's survey had 400 participating companies and included compensation reporting of over 18,000 employees.
The 2016 Wage and Benefit Survey Report includes information about:
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- Annual Salaries
- Health Insurance Benefits
- Human Resource Policies
The report has been distributed to members who participated in the survey. The report is available for $250 for nonmembers. Contact Marybeth to purchase your copy. An in-plant version is also available.


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LEGO Vintage Ford Taunus Auto & "Garage Box" Case Late 1960's, VGC
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LEGO Vintage Ford Taunus Auto & "Garage Box" Great Condition !!!!!!These items are as shown in the photo, and have been in boxed storage since the 1960s! Very rare to find in this condition, both the garage and the auto!!! The underside of the auto is silver color, and states "Ford Taunus 17M" and "Pat. LEGO pend. The underside of the garage states "LEGO System" and "D.B.G.M. angem." Please feel free to ask questions about the item, BEFORE bidding on it! This will be shipped through USPS Priority with Tracking, Thanks! Seller ONLY accepts PayPal. NO cash, checks, etc. I have tried to describe the item as completely and accurately as possible (inc. photo(s)), since all sales are final. Thus, please feel free to ask questions you have concerning the condition or description of the item BEFORE bidding, and I'll respond accordingly. Shipping to domestic (US 50 States) destinations only. NO international shipping. based on my feedback rating!


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That first episode of #TheWalkingDead Season 7, which had us speculating for months before the release, is still not completely off our minds now that the episode has aired, and for good reason: Knowing beforehand that we'd see Lucille do her deed didn't make it any less gut-wrenching, as the brains of not one, but two Alexandria members splattered Rick and his team.
And executive producer #GregNicotero isn't about to let us bury the memory of that gruesome episode just yet, sharing an insider's look at the makeup process that made the baseball bat smashing heads look so incredibly realistic. If your stomach was already twisting at the sight of flesh-hungry zombies, the details of these two cracked skulls should achieve to rid you of any remaining appetite.
Check out the makeup for Glenn over here, and read on to see how Abraham's injuries were brought to the screen.
- The Ultimate The Walking Dead Season 7 Guide: News, Recaps, Promos & All You Need To Know
- Long Live The Walking Dead! AMC's Killer Show Has Been Renewed For An Eighth Season
Step One: A Baseball Bat-Shaped Dip In The Skull
Before creating the prosthetics that would go onto #MichaelCudlitz's head, the VFX team created a mockup of his head and rendered the mark of Lucille right in the middle. Now imagine the effect such a hit would have on the inside of the skull...
Step Two: Recreate The Mark With Makeup
It gets even more chilling when you actually see the wound on Cudlitz's head. Judging from the similarity with Glenn's, though, we have to admit that Negan has great aim.
Step Three: Crush The Dummy
Knowing that it's a fake head still doesn't make Abraham's crushed brains any less horrific, proving once again that practical effects are simply much more efficient to get the feeling across.
Need a little something cheery after so much gore? Watch our cut of Negan's most charming moments:


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Zelda and the Spring of Power - Breath of the Wild
Rated 5 / 5 stars
Just wow! I love the details and style, and the way you incoorporated the game is cool!
Rated 4 / 5 stars
Aw, me too, though I think I'll just go with the Wii U ;)
Anyway, it's a really nice piece, love her expression! It really captures some of the grim and dramatic feeling (that at least I got) from the last trailer :) This makes me even more hyped for the game! >.<
Aww thank you so much! Youre very sweet and I hope you enjoy the game!
Zero Suit Samus Pinup Commission
Rated 4.5 / 5 stars
I love this!
I think this is a fine piece considering it is done traditionally. :) The shading with the markers is especially good, and the combination of colors is nice. Could have gone a little further on the handle of her gun, considering the shading elsewhere in the piece, however keeping it simple also enhances details in the hand.
Good job! <3
Oh good eye! Thanks, I totally forgot about the shading on the handle of her gun.


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Runway models look awesomely perfect most times. We often wonder how they can walk in sky high heels, tight clothes, or barely there fashions. But as these videos show, they're not perfect all the time. Check out these models trip, fall and maybe a little wardrobe malfunction on the runway:
Tag: runway
Naked Models Walk Runway @ London Fashion Week (PHOTOS)
Naked women walked the runway during London Fashion Week. British designer, Pam Hogg, dressed her models in black, red and white shiny materials and odd sculpture-like hats. However, even with some clothes on, the models were naked. Many wore see-through outfits that basically left the models almost completely nude. Check out Pam Hogg's naked runway…


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Low oxygen stimulates pulmonary vascular development and airway branching and involves hypoxia-inducible factor (HIF). HIF is stable and initiates expression of angiogenic factors under hypoxia, whereas normoxia triggers hydroxylation of the HIF-1α subunit by prolyl hydroxylases (PHDs) and subsequent degradation. Herein, we investigated whether chemical stabilization of HIF-1α under normoxic (20% O2) conditions would stimulate vascular growth and branching morphogenesis in early lung explants. Tie2-LacZ (endothelial LacZ marker) mice were used for visualization of the vasculature. Embryonic day 11.5 (E11.5) lung buds were dissected and cultured in 20% O2 in the absence or presence of cobalt chloride (CoCl2, a hypoxia mimetic), dimethyloxalylglycine (DMOG; a nonspecific inhibitor of PHDs), or desferrioxamine (DFO; an iron chelator). Vascularization was assessed by X-gal staining, and terminal buds were counted. The fine vascular network surrounding the developing lung buds seen in control explants disappeared in CoCl2- and DFO-treated explants. Also, epithelial branching was reduced in the explants treated with CoCl2 and DFO. In contrast, DMOG inhibited branching but stimulated vascularization. Both DFO and DMOG increased nuclear HIF-1α protein levels, whereas CoCl2 had no effect. Since HIF-1α induces VEGF expression, the effect of SU-5416, a potent VEGF receptor (VEGFR) blocker, on early lung development was also investigated. Inhibition of VEGFR2 signaling in explants maintained under hypoxic (2% O2) conditions completely abolished vascularization and slightly decreased epithelial branching. Taken together, the data suggest that DMOG stabilization of HIF-1α during early development leads to a hypervascular lung and that airway branching proceeds without the vasculature, albeit at a slower rate.
- vascularization
- lung development
- vascular endothelial growth factor
lung development occurs in a relatively hypoxic environment in utero (32). This may be beneficial for vascular growth since several angiogenic factors are induced by low oxygen (18, 35). Indeed, culturing early embryonic lungs in a low oxygen environment stimulates vascular development (49) and enhances VEGF gene expression (1). Other reports have shown that hypoxia affects lung branching morphogenesis (18, 19). Recent studies have demonstrated that fetal oxygen tension also stimulates branching of the Drosophila tracheal system (4). In most mammalian cells, the response to hypoxia is mediated through hypoxia-inducible factor-1 (HIF-1) (20, 35). The HIF-1 complex consists of one of three α-subunits (HIF-1α, HIF-2α, or HIF-3α) and a β-subunit known as aryl hydrocarbon receptor nuclear translocator (ARNT) (41). The regulation of HIF by oxygen occurs through modifications of the α-subunit, whereas the β-subunit is oxygen insensitive. Under normoxic conditions, proline residues 402 and 564 of the α-subunit are rapidly hydroxylated by prolyl hydroxylase domain enzymes (PHD1-3) allowing recognition of the α-subunit by the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex and subsequent proteosomal degradation (36, 40). In addition, hydroxylation of the asparagine 803 residue in the transactivation domain of HIF-α by an asparagyl hydroxylase, called factor-inhibiting HIF (FIH)-1, inhibits the recruitment of transcriptional coactivator proteins (34, 30). Under hypoxic conditions, PHDs are degraded by SIAH (seven in absentia homolog) E3 ubiquitin ligases (10, 39). The degradation of PHDs allows the α-subunit of HIF-1 to escape hydroxylation and accumulate in the nucleus, where upon binding to ARNT, it recognizes hypoxia response elements (HRE) within the promoter regions of hypoxia-responsive target genes. Numerous genes have HREs, and many of them seem to be involved in endothelial cell proliferation and survival (35).
Herein, we investigated whether chemical upregulation of HIF-1α expression and stability under normoxic (20% O2) conditions would increase vascularization and branching in early lung explants similar to that seen in explants cultured in low (3%) oxygen (1, 18, 19). Either cobalt chloride (CoCl2), dimethyloxalylglycine (DMOG), or desferrioxamine (DFO) was used (11, 15, 38). CoCl2, a transition metal, chemically mimics hypoxia, which stabilizes HIF-1α (28). It is a weak inhibitor of PHD1–3 and a strong inhibitor of FIH (25). In addition, it inhibits VHL binding to HIF-1α even when HIF-1α is hydroxylated (52). DMOG is a nonspecific 2-oxoglutarate (OG)-dependent dioxygenase inhibitor. The 2-OG dioxygenase family includes PHD1–3 and FIH-1 (15). Inhibition of the 2-OG dioxygenase family results in an upregulation of HIF-1α and an induction of oxygen-regulated gene expression (15). Recent studies have shown that PHD inhibition with DMOG enhanced HIF-1α and VEGF expression in lung cells (5). DFO, which removes intracellular iron, is known to stabilize HIF-1α (31). The enzymatic actions of PHDs are dependent on both molecular oxygen and iron (31). DFO inhibits FIH-1, partly inhibits PHD3, and is a weak inhibitor of PHD1 (25). It does not inhibit PHD2 (25). The chemical treatments with CoCl2, DMOG, and DFO to induce vascularization and branching were compared with SU-5416, a well-known inhibitor of VEGFR2 [kinase insert domain-containing receptor (KDR)/fetal liver kinase-1 (flk-1)] signaling and lung development (27).
CD1 and Tie2-LacZ mice were obtained from The Jackson Laboratory, Bar Harbor, ME (42). In Tie2-LacZ transgenic mice, the 2.1-kb 5′ flanking region of the murine Tie2 promoter drives the expression of the bacterial LacZ reporter gene exclusively to endothelial cells (42). Cells transcribing the LacZ gene can be viewed by staining for β-galactosidase activity. The transgenic line was maintained on a CD1 background. All mouse protocols were in accordance with Canadian Council of Animal Care guidelines and approved by the Animal Care and Use Committee of the Hospital for Sick Children, Toronto, ON, Canada.
Whole lung organ culture.
Lung buds were dissected from embryonic day 11.5 (E11.5) CD1 and CD1-Tie2-LacZ mouse embryos (day of vaginal plug is E0.5) and placed on a floating (8-μm Whatman Nuclepore polycarbonate) membrane (Integra Environmental, Burlington, ON, Canada). Explants were grown in DMEM plus 10% FCS (Gibco, Grand Islands, NY) and maintained in an atmosphere of 20% O2-75% N2-5% CO2 at 37°C. CoCl2 (100 μM; Sigma-Aldrich, Oakville, ON, Canada), between 500 and 1,000 μM DMOG (Frontier Scientific, Logan, UT), 10 μM DFO (Sigma-Aldrich), or 20 μM SU-5416 (VEGFR2 kinase inhibitor III, cat. no. 676487; Calbiochem, La Jolla, CA) was added to the medium at day 0. The explant experiments with SU-5416 were carried out in a hypoxic environment (2% O2-93% N2-5% CO2). Medium was changed every other day, branching was assessed every day, and vascular growth was assessed on days 2 and 4. Pictures were taken using a Leica microscope and a digital imaging system.
MTT assay.
Cell proliferation was determined using the Vybrant 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay (V-13154; Invitrogen, Burlington, ON, Canada). The MTT assay involves the conversion of water-soluble MTT to an insoluble formazan. Experiments were carried out according to the manufacturer's protocol. Briefly, at day 2 and day 4 of culture, medium of explants was replaced by phenol red-free medium containing 1.09 mM MTT, and the conversion to formazan was allowed to continue for 4 h. The formazan was then solubilized by adding SDS-HCl (0.35 M SDS in 0.01 M HCl) to the medium, and incubation continued for another 16 h. The concentration of formazan was determined by measuring the optical density at 570 nm.
LacZ staining.
LacZ lung explants were fixed (in 1% formaldehyde, 0.1% glutaraldehyde, 2 mM MgCl2, and 5 mM EGTA in 0.1 M sodium phosphate buffer, pH 7.8–8.0, for 45 min at 4°C), washed (in 2 mM MgCl2, 0.01% deoxycholate, and 0.02% Nonidet P-40 in 0.1 M sodium phosphate buffer, pH 7.8–8.0) four times for 30 min at 4°C, stained overnight at 37°C in X-gal staining solution [5 mM K4Fe(CN)6:3H2O, 5 mM K3Fe(CN)6] in wash buffer, and mixed 40:1 with X-gal stock solution (40 mg/ml in dimethyl formamide). Explants were washed with PBS, fixed in 4% paraformaldehyde in PBS overnight at 4°C, and stored in 70% ethanol. All explant cultures were stopped at the same time to make comparison over various treatments possible. For imaging, explants were dehydrated with graded alcohol, placed in 100% methanol, and cleared in methyl salicylate. Digital images were taken with a Leica MZ12 stereomicroscope equipped with a digital imaging system. Vessel density (ratio of vessel pixels to whole lung pixels) was determined using Openlab software (Improvision, Lexington, MA). For sectioning, explants were dehydrated in a graded series of ethanol and embedded in paraffin. Twelve-micrometer thick sections were mounted on Superfrost slides (Fisher Scientific, Unionville, ON, Canada) and counterstained with nuclear fast red. Digital images were taken with a Leica DM6000 microscope equipped with a digital imaging system.
Nuclei isolation and Western blotting.
E11.5 lung explants were cultured for 48 h in DMEM plus 10% FCS with and without 10 μM DFO, 100 μM CoCl2, or 500 μM DMOG. Lungs were then combined into pools containing 12 explants for each culture condition. Nuclear extracts were prepared essentially as described elsewhere (2). Each pool was washed in ice-cold PBS and resuspended in 0.5 ml of ice-cold, low salt buffer A [10 mM HEPES-KOH, pH 7.9, 1.5 mM MgCl2, 10 mM KCl, 0.5 mM DTT, 0.2 mM phenylmethylsulfonyl fluoride (PMSF), and EDTA-free protease inhibitor mixture (Roche Diagnostics Canada, Laval, Québec, Canada)]. Samples were then homogenized using 23-gauge followed by 30-gauge needle aspiration, vortexed, and placed on ice for 10 min. Nuclei were centrifuged at 10,000 g for 2 min, and the pellet was resuspended in 0.5 ml of buffer A, centrifuged again, and resuspended in 0.2 ml of high salt buffer C (20 mM HEPES-KOH, pH 7.9, 26% glycerol, 420 mM NaCl, 1.5 mM MgCl2, 0.2 mM EDTA, 0.5 mM DTT, 0.2 mM PMSF, and EDTA-free protease inhibitor mixture). Nuclei were incubated on ice for 30 min and centrifuged at 10,000 g for 5 min to remove cell debris. Three micrograms of nuclear lysate protein was subjected to 10% SDS-PAGE, transferred to nitrocellulose membrane, and immunoblotted using rabbit polyclonal anti-human HIF-1α (1:1,000; Cell Signaling Technologies, Danvers, MA).
RNA isolation and real-time RT-PCR.
After 4 days of culture, lung explants were rinsed in ice-cold PBS, immediately frozen in liquid nitrogen, and stored at −70°C. RNA was extracted with the RNeasy kit (Qiagen, Mississauga, ON, Canada). Total RNA was reverse-transcribed (37°C) in a total volume of 50 μl using random hexamers (Invitrogen). The resulting templates were quantified by real-time PCR (ABI Prism 7700; Applied Biosystems). Primers and Taq Man probes for HIF-1α, VEGF, and VEGFR2 (KDR/Flk-1) were purchased from Applied Biosystems as Assays-on-Demand for murine genes. Reactions were carried out in 96-well plates in triplicate. For each probe, a dilution series determined the efficiency of amplification of each primer-probe set, and the relative quantification method was employed (33). For the relative quantitation, PCR signals were compared among groups after normalization using 18S as an internal reference. Relative expression was calculated according to Livak and Schmittgen (33). P < 0.05 was considered statistically significant.
Inhibition of VEGFR2 signaling blocks vascularization and slightly decreases epithelial branching.
We first investigated whether inhibition of VEGF/VEGFR2 signaling affected vascular growth and epithelial branching morphogenesis using CD1-Tie2-LacZ mice. Lungs were dissected at E11.5 and cultured in 2% oxygen to stimulate optimal vascular growth (49). Whole mount LacZ staining revealed that incubation of E11.5 mouse lung explants with SU-5416, a cell-permeable selective ATP-competitive inhibitor of VEGFR2 (Flk-1/KDR), completely abolished vascular growth. Inhibition of vascular development (absence of X-gal positive vessels) was already noticeable after 24 h of incubation (Fig. 1, B vs. D), whereas epithelial branching appeared unaffected (Fig. 1, A and C). After 48 and 96 h of incubation of lung explants with SU-5416, a small but significant decrease in epithelial branching was noticed compared with control explants (Fig. 2). Thus epithelial branching proceeded without vascular development, albeit at a lower rate (Figs. 1 and 2).
Chemical induction of HIF.
Since low oxygen has been shown to stimulate VEGF expression in murine lung explants, most likely via HIF-1 (49), we investigated whether enhancing HIF-1α stability under normoxic (20% O2) conditions would promote vascular development and, thereby, epithelial branching. E11.5 lungs from CD-Tie2-LacZ mice were incubated with either CoCl2, DMOG, or DFO to stabilize HIF-1α. First, we determined the dose-toxicity curves of CoCl2 and DFO for lung explant growth and branching (Fig. 3). Based on these pilot studies, we used 100 μM CoCl2 and 10 μM DFO in the subsequent explant experiments. These CoCl2 and DFO concentrations have previously been shown to increase HIF-1α protein amounts in various cell (37, 48, 49) and tissue systems (14). Dose-toxicity curves showed that explants started to disintegrate when exposed to between 500 and 1,000 μM DMOG for more than 48 h (Fig. 4). Since DMOG has been reported to stabilize HIF-1α at concentrations of >500 μM (26, 53), we exposed explants in subsequent experiments to 500–1,000 μM DMOG for maximally 48 h. Lungs cultured with CoCl2 showed a significantly decreased vascular LacZ staining after 48 h of culture compared with control lungs (Fig. 5, E, F vs. B, and C). Also, DFO treatment resulted in reduced vascular development (Fig. 5, G, H vs. B, and C). The fine vascular network surrounding the developing lung buds seen in control explants had disappeared in CoCl2- and DFO-treated explants. The X-gal positive vessels along the trachea, main bronchi, and larger airways appeared to be unaffected, especially in the DFO treatment group. After 96 h of culture, vascular growth was further reduced in explants treated with CoCl2 and DFO (Fig. 6, B and C vs. A). Epithelial branching was significantly reduced in explants treated with CoCl2 and DFO (Figs. 3 and 6E). Addition of 50 μM FeCl2 to DFO-treated explants reversed the inhibitory effect of DFO on vascular growth and epithelial branching (Fig. 7). Of note, FeCl2 addition did not completely overcome CoCl2-induced inhibitory effect (data not shown). Epithelial branching and vascular growth were not affected by low dosages (between 25 and 100 μM) of DMOG (Figs. 4, 6, and 8A). However, concentrations of >500 μM DMOG stimulated vascularization while inhibiting epithelial branching (Figs. 4 and 8, A–C). The Vybrant MTT assay was performed to determine the effect of CoCl2, DMOG, and DFO on explant cell growth. CoCl2, DFO, and DMOG (>500 μM) treatment of lung explants markedly inhibited cell proliferation compared with control explants (data not shown). These findings agree with the branching morphogenesis results.
To determine the effect of the treatments on HIF-1α protein expression, nuclei were isolated from explants after 48 h of culture. Western blot analysis of nuclear lysates revealed that DFO and DMOG treatments increased HIF-1α protein content, whereas CoCl2 had no effect (Fig. 9A). Next, we investigated the effect of treatments on HIF-1α, VEGF, and VEGFR2 (KDR/Flk-1) mRNA expression by real-time PCR. None of the treatments affected HIF-1α mRNA expression (Fig. 9B). All treatments increased VEGF mRNA expression while reducing VEGFR2 mRNA expression.
Previously, we (49) have reported that low oxygen levels enhance epithelial branching morphogenesis and vascular development in E11.5 murine lung explants. We hypothesized that HIF-related pathways were involved, and, indeed, antisense knockdown of HIF-1α mRNA expression decreased epithelial branching morphogenesis and vascularization (49). Herein, we show that inhibition of VEGF/VEGFR2 signaling with SU-5416 completely abolished vascular growth. However, epithelial branching proceeded without vascular development, albeit at a slower rate. This indicates that HIF/VEGF signaling is important for vascularization but that other downstream targets of the HIF pathway play a role in epithelial branching. Also, it suggests that epithelial branching is not as tightly linked to vascular development in the early phase of lung development as previously thought (49). Galambos et al. (17) showed that later in gestation (>E16), loss of one VEGF allele led to a decrease in lung development, suggesting that vascularization plays a greater role in epithelial branching at later gestation. This is supported by studies in which a VEGFR2 inhibitor was administered postnatally (days 1–13) to rat pups. Treated animals had enlarged air spaces, decreased alveolar number, and decreased arterial density (27). Endothelial monocyte-activating polypeptide II (EMAP II), another anti-angiogenic agent, decreased vessel density and arrested airway epithelial morphogenesis in E14.5 lung allografts (43).
VEGF expression in murine lung explants is stimulated by low oxygen, most likely through a HIF-mediated mechanism (49). Stimulation of HIF protein via inhibition of PHDs has been reported to enhance expression of VEGF and platelet endothelial cell adhesion molecule (PECAM) both in vivo and in vitro (7, 8). Furthermore, it stimulated in vitro angiogenesis (5, 7). Intravenous treatment of preterm baboons with a PHD inhibitor (FG-4095) was shown to be effective for HIF protein stabilization (5, 7). Another study showed that this treatment is associated with enhanced lung growth, improved oxygenation, and lung compliance (6). Thus the increase of HIF proteins goes hand in hand with improved postnatal lung development. In the present study, we observed that chemical stabilization of HIF-1α in early lung explants with the nonspecific PHD inhibitor, DMOG, increased vascularization but decreased branching. The latter is opposite to our previously reported effect of low oxygen on explant branching (49).
In explants treated with CoCl2 and DFO, the fine vascular network surrounding the developing lung buds disappeared, whereas the vessels along the trachea, main bronchi, and larger airways remained intact. Although VEGF expression was upregulated, VEGFR2 expression was downregulated by both treatments. It is possible that VEGFR2 downregulation is responsible for the lack of peripheral vascularization since VEGF-VEGFR2 signaling is important for the sprouting of new vessels from existing ones, and VEGF is a potent mitogen for endothelial cells (for review, see Ref. 50). However, in explants treated with SU-5416, not only the finer vasculature disappeared, but also the larger more proximal vasculature. An explanation may be that SU-5416 is not solely a VEGFR2 inhibitor, but also a PDGF β-receptor inhibitor. VEGFR2 accounts for most VEGF effects on endothelial cells such as cell proliferation, NO and prostacyclin production, angiogenesis, and vascular permeability (23, 46). The PDGF β-receptor is activated by PDGF-B, which is a potent mitogen of vascular smooth muscle cells (VSMC) and is also involved in the migration of pulmonary VSMCs (12, 50a). Inhibition of both VEGF and PDGF pathways has been shown to be more effective than blocking VEGF alone, causing vessel regression in multiple models of neovascular growth (29). Thus the blockade of both receptors may explain the complete absence of vascularization seen in explants incubated with SU-5416.
Although upregulation of VEGF mRNA in the lung explants by all three treatments suggests stabilization of HIF-1α (49), we found that only DFO and DMOG increased nuclear HIF-1α levels. CoCl2 is a strong inhibitor of FIH-1 but not PHDs (25). Recent studies have shown that FIH-1 regulates selectively the expression of a variety of HIF-induced genes, in particular VEGF (13). It is plausible that CoCl2 inhibition of FIH-1 stimulated HIF-1α transactivation activity and, thereby, VEGF mRNA expression in the explants without increasing HIF-1α protein. As discussed above, the increase in VEGF expression by CoCl2 and DFO did not lead to improved vascularization. Moreover, lung explant growth and branching was severely reduced. Both CoCl2 and DFO interfere with binding of molecular oxygen to heme proteins, thereby mimicking hypoxia. It is possible that the hypoxia was too extensive and led to cell death. DFO and CoCl2 have been shown to induce apoptosis in a variety of nonlung cells (3, 21, 44). However, no increase in apoptotic or necrotic cell death of fetal alveolar type II cells was reported when the cells were exposed to 3% O2 (22). In the latter study, the fetal cells were exposed to 3% O2 only for 24 h. To prevent oxygen depletion and cell death, cells exposed to very low oxygen levels downregulate ATP-consuming pathways to decrease oxygen demand. The reduction in oxygen consumption in A549 cells was, however, not reversible after the cells were exposed to hypoxia for 24 h (24). Thus the prolonged CoCl2- or DFO-induced hypoxia likely triggered cell death in the lung explants. Together with the reduction in cell proliferation, this may explain the negative effect of both treatments on lung growth and branching. Moreover, CoCl2 and DFO will not only act as hypoxia mimetics but interfere with all ferro-dependent reactions needed for proper vessel formation and airway branching. The importance of iron for proper lung development was demonstrated by the reversal of the inhibitory effect of DFO with excess iron. These additional effects of DFO may explain the discrepant results between DFO and DMOG. Both increased nuclear HIF-1α protein and VEGF mRNA expression, but only DMOG stimulated vascularization. It is worthwhile mentioning that DMOG has been shown to inhibit hydroxyproline synthesis in lung (9). This may explain negative effect of DMOG on branching as collagens have been shown to be important for proper lung branching (45). Recently, it has been reported that the specific PHD inhibitor FG-4095 stabilizes HIF-1α protein and stimulates the expression of angiogenic factors, including VEGF, in primate lung explants cultured under hyperoxic conditions (7). Unfortunately, its effect on early lung morphogenesis was not determined.
This work was supported by the Canadian Institutes of Health Research (CIHR) (M. Post and I. Caniggia), the Sophia Foundation for Medical Research (Grant 460 to F. A. Groenman), and Canadian Foundation for Innovation (CCURE) (M. Post). M. Rutter was supported by a Hospital for Sick Children Graduate Scholarship. I. Caniggia is the recipient of an Ontario Women's Health CIHR/Institute of Gender and Health Mid-Career Award. M. Post is the holder of a Canadian Research Chair (Tier 1) in Fetal, Neonatal, and Maternal Health.
We thank Angie Griffin for animal handling and care.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2007 the American Physiological Society


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Madhurima to create problems in Aditya and Samira's wedding . To know Madhurima's devilish plans. Do watch the ...Added on : Friday, June 27, 2014 at 12:00:00 AM
Samaira of Main Na Bhoolungi talks about her bridal attire in an exclusive chat with India-Forums. Don't forget ...Added on : Wednesday, June 25, 2014 at 12:00:00 AM
Sony tv's popular show Main Naa Bhoolungi completes 100 successful episodes.Added on : Thursday, May 22, 2014 at 12:00:00 AM
Though Aditya plans to kill Samayra in Main Naa Bhoolungi, but before that he is eager to know how she knows ...Added on : Monday, May 12, 2014 at 12:00:00 AM
Take a look on some of the characters from television who are the replica of famous Bollywood characters.Added on : Thursday, May 08, 2014 at 12:00:00 AM
The cold war between Madhu and Samaira has intensified as Madhu plans a wardrobe malfunction for Samaira. To know ...Added on : Wednesday, May 07, 2014 at 12:00:00 AM
Sony Tv's show Main Na Bhuloongi to witness a romantic scene between Aditya and Samaira.. Finally Aditya will ...Added on : Wednesday, April 23, 2014 at 12:00:00 AM
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Buying a home is a challenging task in one's life. Once you have enough cash to purchase your own property, then you should be watchful in obtaining one. There are various types of properties, contingent upon your financial plan and preferences. Thus, you need to pick one that suits the needs of your whole family.
Wherever you choose to buy your own home, you have to ensure your security and comfort. There are a lot of options available out. Some you can buy fully furnished and some you can customize. Simply search for the perfect package that fit both your lifestyle and budget.


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By Brieanah Gouveia
Not often do students have the opportunity to readily see the work of their professors, which is what makes faculty art exhibitions a great treat. Olin Hall Galleries hosted its Fine Arts Faculty exhibition on Jan. 29 and will continue into this month. On display in Olin Gallery were the varying works of Professors Scott Hardwig, Elizabeth Heil, and Katherine Shortridge, as well as lecturer Jennifer Ruhland.
The installation of Hardwig,– professor of sculpture and ceramics, – features panels of ceramic dishes with the theme of "Nouns, Names, and Verbs," inspired by the Periodic Table of Elements. Each plate features a combination of four individual elements that spell out words, and many, when read in conjunction, make simple sentences and even full jokes. The words featured on the plates range from ancient figures in Greek mythology such as "PaNdORa," to figures of contemporary pop culture like "LaDy GaGa." The words reach even broader in scope from "MoRaLiSm," to "RuDaBaGa." An interactive component of the installation features an animated shadow box that illuminates certain elements to the course of The Supremes' song "Na Na Hey Hey." Dozens of these dishes sold at the opening and many of the quirky creations are still left for purchase.
Representing the 2-D arts are the works of Professors Heil and Shortridge. Heil's installation showcases computer-manipulated photographs in which a female character is placed in various dollhouse settings. A series of graphic design floor works make up the second aspect of her installation. Shortridge's installation features abstract acrylic and pastel paintings, in which the interplay between color, line, and form make for breathtaking compositions.
In Smoyer, Ruhland's installation, "From the Page to the Stage," showcases actual costumes she has designed for different theater performances. The array of dresses come from plays such as Sense and Sensibility to Antigone, and display Ruhland's great breadth. Five of the features are from Roanoke's own theater, as she is the college's resident costume designer. Others are from Mill Mountain Theater and the University of Virginia. In addition to the outfits and accompanying photographs of her costumes in action, an entire wall in Smoyer depicts Ruhland's design process. Reference photographs, watercolor illustrations, and material samples enhance the feeling of her installation by giving insight into the artist's studio.
The Fine Arts Faculty Exhibition undoubtedly reveals the diversity of talent and skill among the professors of Olin. Students, family and friends of the showcased faculty enlivened the gallery space that evening. The exhibition will be on display through Feb. 28. The Gallery is open 7 days a week, from 1 pm – 4 pm.


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- rated 4.35 / 5 stars
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- Comedy - Original
- animals
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- Frontpaged February 11, 2009
- Daily Feature February 10, 2009
If you liked this, check these out!
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Author Comments
Rated 4.5 / 5 stars
He got problems
This isnt a bad animation. I have seen all of your cat face animatins and I say this is one of the best ones.
Rated 3.5 / 5 stars
Is he made of, like, helium, or something?
Seriously? How does he fly through the air? Is it just because he's got a catface? Or is it because hes got the body of a cat and the face of a cat? Silly catface...
Rated 4 / 5 stars
Is Catnip supposed to be a drug in this episode lol very fine quality of animation you are my favorite author and the pace and sense of timing is usually perfect in the whole series the storylines are always really funny my favorite character is BoxCat.
Rated 5 / 5 stars
caatace hes got a big cats face and the body of a cat and the face of a cat and he flies throught the air cause hes got got a cat face. B-)
Rated 5 / 5 stars
Save energy - save Cat Face
Lol as always....
The more i watch the more i like that cat
I wanna that cat too(not box cat)


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Black panther warning as cops urge people to lock their doors and windows
COPS were called to reports of a black panther on the prowl in the suburbs on Manchester.
Greater Manchester Police received a call from a panicked resident who claimed they had seen a black panther hunting in fields just off Bury New Road.
The Sun Online reports the caller was adamant the creature was a large black panther and insisted to the operator the creature was "definitely not a dog and definitely not a cat".
GMP Sergeant John Foxcroft said the man said "he saw a large black panther and he saw it running across the fields".
Remember to check your doors and windows before you go to bed. We wouldn't like you to be a victim of burglars or black panthers.#security— GMP Radcliffe (@GMPRadcliffe) July 20, 2016
"We were called to reports that a large black panther was running round farmers' fields"GMP spokesman
The cops said they could not find the beast or any trace of it.
The search for the big cat has now been suspended but police warned locals to check their doors and windows before bedtime.
The latest big cat sighting comes after a lynx escaped from a zoo in Dartmoor.
A spokesman for Greater Manchester Police said: "We were called to Bury New Road at 2.26pm to reports that a large black panther was running round farmers' fields off Bury New Road.
"The caller said it was at the back of his house and the panther was chasing two deer. He said he had called the council and RSPCA and was advised to contact police.
"He last saw it running towards Somerton Road. When officers went, they found no sign of the animal."


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MHA Aging Committee Meeting
The MHA Aging Committee promotes the concept that "Mental Health is Ageless" by offering the community a number of different educational opportunities through senior forums for older adults and workshops and presentations about older adults and mental health for professionals.
Organizer Karen George
For more information or to RSVP, please contact Karen George at email@example.com.
Tue, April 3, 2012
1 p.m. - 2:30 p.m.
(GMT-0600) US/Central
MHA Offices, 2211 Norfolk, Suite 810


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Item description for Tozer on Christian Leadership: A 366-Daily Devotional (Tozer For Today #2) by a w tozer...Overview
Tozer in Christian Leadership is the second book in the "Tozer for Today" series. It features 366 carefully chosen daily devotional readings excepted from more that forty Tozer books and accompanied by a scripture verse and prayer.
In the introduction Eggert notes, "I have sought to glen from this humble, self-taught-no, Spirit-taught-pastor thoughts that might stimulate and minister to others involved in Christian leadership. . .Let the Holy Spirit stimulate your own heart to respond personally to these incredibly poignant thoughts. Your life and ministry will never be the same!"
These are twelve themes, one for each month: Personal Life, The Holy Spirit, Pastoral Ministry, Prayer, Preaching, Worship, The Church, Evangelism, Revival, Failure and Success, Spiritual Warfare and Sin, Trials and Pain.
Scripture index included.
Publishers Description
"Tozer on Christian Leadership" by A.W. Tozer is a 366 day devotional on the topic of Christian leadership. The idea of Christian leadership is broad and can seem unimportant to someone not in an administrative or ministerial position. But it is much deeper than that and has ramifications that stretch into the personal and spiritual life of every Christian. To lead is to foster a more submissive relationship with God the Father while taking moral authority over the forces of the world. Tozer uses the image of obedience to lay the groundwork for his yearlong devotional on Christian leadership.
As Abraham, the oldest of the Church fathers, was on his face before God, so should our position of obedience be to God. Leadership, he says, comes from this place of submission. Over the course of the year, Tozer goes over many different aspects of leadership, including that of the personal life, evangelizing and a spiritual revival of the church. Tozer challenges the believer to take an attitude of humility before God and men, and listen patiently to the whispering inner voice. Tozer declares, "Let Him work and your spiritual life will begin to blaze like the rising sun."
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This shaker was inspired by the traditional aesthetic of copper stills (copper removes the unpleasant tasting sulfur-based compounds from alcohol) and the renewed interest in artisanal cocktail making. The copper manufacturer that crafts these shakers is nearly 200 years old, and prides itself on creating historically accurate wares. If cared for properly, the makers intend for these copper cocktail shakers to become family heirlooms. The cup is lined with stainless steel so that you can shake up any concoction without worrying about the acidity eroding the copper. A stainless steel top easily slides on and off for swift pouring, ensuring your drink is still properly chilled when it reaches your glass.
Hand wash with warm soap and water. Never place in dishwasher. Copper is a metal that will not rust, as long as it is not exposed to acids. Over time and with regular use, the copper cup of the shaker will change in color and surface texture. This is not damage, but simply the copper molecules settling in and getting comfortable. A naturally occurring patina will develop to create a one-of-a-kind finish. If you prefer to restore the original copper sheen, polish the cup with a soft cloth and cleaning solution. Acid corrodes copper, the inside is lined with stainless steel, allowing you to shake up citrus-based beverages without worry of ruining your shaker. If you want to clean the inside of the steel-lined copper cup, rinse with warm water and mild soap, then dry thoroughly. Each shaker is individually made, so imperfections are expected and contribute to the uniqueness of your handmade vessel. Because copper is a soft metal, engraving can potentially compromise the structure or integrity of the product and is not recommended.
This metalworking company is careful to adhere to the same standards of materials and fabrication set almost 200 years ago at its founding. The cup and cap are created in a process called metal turning or metal spinning. Pieces of metal – in this case, copper – are spun and turned on a lathe at high speeds. A forming block pushes against the material as it spins to create symmetrical, round and tubular items. The cups are lined with stainless steel on the interior, so that you can mix your cocktails without worry of corrosion and damage.
Pure copper shaker lined with stainless steel to prevent corrosion from acidity and resist rust. Made in the U.S. by a copper manufacturer founded in 1819. Each piece is handmade, and therefore unique. Holds 14 fluid ounces.
3 inches at widest point x 8 ½ inches high (with top)
(7.6 cm x 21.5 cm)
Holds 14 fluid ounces (0.04 liters)
Pure Copper
Stainless Steel
Made in
Because copper is a soft metal, engraving can potentially compromise the structure or integrity of the product and is not recommended.
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These Z-Series Clamps are available in your choice of round or square shapes, and come in either economical zinc, or durable stainless steel construction. Z-Series Glass Clamps are available in sizes to accommodate glass thicknesses from 1/4 to 1/2 inch (6 to 12 millimeter).
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Minster FM News
Arts Grants Awarded in East Riding
12:33pm 15th May 2013
East Riding of Yorkshire Council is maintaining its support for the arts across the region by awarding grants totalling nearly £50,000 to eight organisations.
Councillor Richard Burton, the council's portfolio holder for civic wellbeing and culture, said :"I am absolutely delighted that we have been able once again this year to award these grants, even in this challenging financial climate.
"It is vitally important that we continue to support the arts in the area where we can, because there is no doubt that a thriving arts scene contributes to the quality of life of our residents, and to the experience of tourists to the region. Successful arts events and organisations also contribute greatly to the local economy and allow residents to develop new skills and abilities, whilst at the same time having fun".
The list of arts grants from the council for the Minster FM area is as follows:
* Beverley and East Riding Early Music Festival : £10,800 awarded to co-ordinate, programme and run the festival annually, including a series of school workshops
* Pocklington Arts Centre: £5,400 awarded to expand a programme of diverse, challenging and innovative theatre productions and workshops for adults and young people


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Kyrosera.com (For One Month of Free Reseller Service)
Kyrosera.com is for sell as of now. The domain name is registered for one year of service and expires December 23, 2005. The domain name has a loose meaning, often refered to as People Friendly. I would be more than happy to trade in the domain name for a reseller web hosting service free for one month of service and then payable via Pay Pal the following months if you would permit a reasonable offer.
If you would be willing to offer me a WHM account reselling cPanel and Fantastico web space with a large reasonable ammount of web space the domain name is your when the reseller service is activated under my account domain InvisionServices.net. If you would like the domain name in exchange for service please email me directly at: firstname.lastname@example.com , your replies here may not be viewed, please use email only.
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Become a volunteer
As we do not have a physical office, there are no possibilities for internships. However, we could use your time as an online volunteer! Please check out the current short assignment(s) below.
1) Finding resoures for the Information Centre
The IFHHRO Information Centre is part of the IFHHRO Right to Health Wiki. We have been collecting books, reports, manuals, databases etc. on the right to health. We could use your help in expanding these lists. If you are interested in this assignment, please contact us, see below.
2) Updating the IFHHRO Wiki
We are looking for volunteers who are willing to (re)write or update one or more of our Wiki pages on health and human rights. If you are interested in this assignment, please go to the IFHHRO Right to Health Wiki.
Check out the section Health and Human Rights by Theme (see the right-hand column). Here we collect information on specific themes (suggestions welcome!). You can choose either an existing theme and rewrite the texts, or a suggested theme and write new texts. We'd also appreciate it if you could collect useful resources (books, reports, etc.) on the theme chosen.
What's in it for you?
After you have finished the assignment, you will be acknowledged as an author in the section that you wrote or updated. And at request, we can send you a letter of recommendation to help you increase your chances in finding a (new) job.
Still interested?
If you are still interested in contributing to our Wiki, please contact our communications person (Nel van Beelen) and send her some information about:
- who you are
- what you would like to do
- when you could do the job (including a self-imposed deadline)
Please note that our time is limited so we cannot give you extensive guidance. However, you will receive written guidelines and you can always contact us for more information.