text: Molecular and cellular biomarkers in dry eye disease and ocular allergyEnríquez-de-Salamanca, Amalia; Bonini, Stefano; Calonge, MargaritaCurrent Opinion in Allergy and Clinical Immunology: October 2012 - Volume 12 - Issue 5 - p 523–533 doi: 10.1097/ACI.0b013e328357b488 EYE ALLERGY: Edited by Leonard Bielory and Stefano Bonini Abstract Author Information Purpose of review To summarize recent studies in biomarkers in dry eye disease (DED) and ocular allergy in the last 18 months. Recent findings New significant correlations with clinical symptoms and signs have been described for some tear molecules (proteins, cytokines/chemokines, metalloproteinases, mucins and lipids). Correlation with disease severity has been shown for some of them. New proposed DED biomarkers include some proteins, such as S100A8, S100A9, lipocalin-1, secretory phospholipase A2 and some cytokines and chemokines; mucin-1 mRNA conjunctival expression levels are shown to be a very sensitive and specific DED diagnosis biomarker; metalloproteinase-9 tear level is confirmed as a good DED biomarker; cell parameters such as conjunctival cell viability and proliferative capacity have been also proposed as DED biomarkers. In ocular allergy, protein activated receptor-2, heat shock protein-70, eosinophil cationic protein and hemopexin have been pointed as potential biomarkers. Characterization of neuromediators tear levels confirmed the involvement of these molecules in both DED and ocular allergy. Summary Biomarkers are essential to monitor health status. Several studies have proposed different molecules and/or cellular parameters as potential biomarkers for DED and ocular allergy. The knowledge presented in these studies will further add support to the discovery and development of new drugs and the establishment of personalized medicine. aIOBA (Institute of Applied Ophthalmobiology), University of Valladolid, Valladolid bNetworking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain cDepartment of Ophthalmology. University of Rome Campus BioMedico, Rome, Italy Correspondence to Amalia Enríquez-de-Salamanca, IOBA, University of Valladolid. Paseo de Belén 17, E-47011, Valladolid, Spain. Tel: +34 983 186369; e-mail: email@example.com Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.


text:
Mark Vincent Müller
Born 1965 in Sierra Leone, Western Africa, Mark Vincent Müller returned to his native country of Switzerland at the age of four. In his youth he grew up watching nature documentaries, knowing one day he would explore African wildlife himself. He kept reptiles and never missed an opportunity to venture in the forests surrounding his home to observe the local flora and fauna. During his early adulthood, Mark became one of Switzerland's leading close-up magicians, performing on TV and top events nationwide. But it was a trip to America which sparked an interest in photography when friends praised his holiday slideshow.
In 1990 Mark set off to Southern Africa with camera equipment and a 4x4 Land Cruiser filled with camping gear, hoping to create his own collection of the nature photography which inspired him in his youth. Over the next few years he would travel to Namibia, Botswana, Zambia and South Africa, living for several months in each location. The Namibian desert in particular became a fascination for him, with many of his photographs capturing the incredible survival of life in this harsh paradise. During these trips his ambition is to inherit the energy and atmosphere of a place and its wildlife. "I try to let myself drift with the essence of what makes an environment special and unique", he says of his work and travels, "I believe that wildlife should be shown embedded in their habitat". His photography has also lead him to the clouded rainforest of Costa Rica, the American Southwest, and to capture some India's last free roaming tigers.
Mark describes his photography as poetic and passionate, his images as "colour, light, and composition reduced to the max". "The world is full of fantastic colours, yet I reduce them to monochromatic interpretations. Almost all of my images show only one or two colours, rarely more as I find that photographs are more striking and memorable if they carry a strong colour theme", he explains. "My images are very clear in their statement and focus precisely on the subject. Each image tells a story of a specific place or animal, expressing the symbiosis between that animal and the world it lives in. The big challenge is to show an unspectacular animal in a dramatic way using the surrounding landscape as the stage and decoration." Asked what is the most important aspect of photography, Mark replies "Light. Without light there is no photography. I am very aware of light and shadows and will return to a place many times if possible to get it right."
Mark's work has been published in numerous magazines, books, calendars and advertising worldwide, including his self-published books "Namibia: The Living Desert (1996) and "Etosha: Place of Dry Water (1999)" which enjoyed much success. Currently he lives with his wife and children in Switzerland, working as a Manager in a software company. Many of Mark's best work remains unpublished and he is in the process of developing an extensive website of his images.
- 2,467 Affection
- 45,065 Photo Views
- 3,903 Followers
- 34 Following

subset: commoncrawl


text:
- Home
- About Us
- Pet Library
- Links
- Contact Us
- Client Forms
- Pain Prevention
- Pet Wellness
- Dental HealthCare
- Pet loss
- Coupon
- Friends & colleagues
- Site Map
- Other Features
Wellness Testing for the Life Stages of Your Pet
The Sunnyside Animal Clinic has established a preventative Wellness Program that focuses on the Life Stages your pet will progress through: Juvenile, Adult, Senior and Geriatric. Our goal is to provide you with the knowledge and tools necessary to ensure that your pet has the longest and healthiest life possible. The program emphasizes prevention and the early detection of disease whenever possible. Use the Life Stage Chart to identify the proper life stage of your pet based on its age and weight.
As each new life stage is reached, we will


text:
Richard J Barker eBooks
eBooks found: 1
Bayesian Inference
Richard Barker & Richard J Barker & William Link & William A Link
Elsevier S&T, August 2009
Format: PDF
eBookMall is a recognized leader in eBooks. eBook downloads in PDF and ePub formats.
Choose from 600,000+ eBooks and get a Free eBook download now!
Copyright © 2000-2017 eBookMall.com This website is subject to copyright laws and may be covered by other intellectual property.
All rights reserved.


text:
Gansu Provincial Key Laboratory of Aridland Crop Science Gansu
Gansu Provincial Key Laboratory of Aridland Crop Science Gansu
Wang J.,Gansu Provincial Key Laboratory of Aridland Crop Science Gansu |
Wang J.,Gansu Agricultural University |
Yao L.,Gansu Provincial Key Laboratory of Aridland Crop Science Gansu |
Yao L.,Gansu Agricultural University |
And 16 more authors.
Frontiers in Plant Science | Year: 2016
Soil salinity severely threatens land use capability and crop yields worldwide. An analysis of the molecular mechanisms of salt tolerance in halophytes will contribute to the development of salt-tolerant crops. In this study, a combination of physiological characteristics and iTRAQ-based proteomic approaches was conducted to investigate the molecular mechanisms underlying the salt response of suspension cell cultures of halophytic Halogeton glomeratus. These cells showed halophytic growth responses comparable to those of the whole plant. In total, 97 up-regulated proteins and 192 down-regulated proteins were identified as common to both 200 and 400 mM NaCl concentration treatments. Such salinity responsive proteins were mainly involved in energy, carbohydrate metabolism, stress defense, protein metabolism, signal transduction, cell growth, and cytoskeleton metabolism. Effective regulatory protein expression related to energy, stress defense, and carbohydrate metabolism play important roles in the salt-tolerance of H. glomeratus suspension cell cultures. However, known proteins regulating Na+ efflux from the cytoplasm and its compartmentalization into the vacuole did not change significantly under salinity stress suggesting our existing knowledge concerning Na+ extrusion and compartmentalization in halophytes needs to be evaluated further. Such data are discussed in the context of our current understandings of the mechanisms involved in the salinity response of the halophyte, H. glomeratus. © 2016 Wang, Yao, Li, Meng, Ma, Lai, Si, Ren, Yang, Shang and Wang.


text:
The Building Construction Certificate Program at the School of Continuing Studies at Long Island University's Brooklyn Campus is designed to attract individuals seeking an understanding of the building construction industry, either as a perspective apartment dweller or homeowner looking to perform renovations or as an entry-level employee looking to begin a career in the industry.
The program is specially designed for those who need the building construction entry-level and small business start-up skills.
$1,145 Tuition subject to increase during academic year
To Apply to the Construction Certificate Program
Please fill out the application form in Registration and submit.
For more information
Email us at firstname.lastname@example.com.
The following courses are required for successful completion of the certificate program.
BCCP 1001 Understanding the Building Construction Process
Students will gain an understanding of how a basic project team works. Defining roles and responsibilities, processes for design and construction and understanding how outside factors influence the process. Oversight success and safety will be covered during this unit. (30 hours)
This course focuses on the design process for a project. Students are taught how "Green Building" concepts are integrated into the building construction process. Describing the project team, how an idea takes shape physically and the various stages of design are covered. The course also covers considerations for budget schedule and client expectations, using actual industry examples. Documentation relating to bidding processes, submittals and approvals and project closeout are reviewed. (30 hours)
How contractors are hired, bidding, negotiating and qualifications based selection are reviewed. Spreadsheet fundamentals, bid clarifications and qualifications and various contract types are discussed during this course. The "do's" and "don'ts" of the construction industry are discussed, featuring recent industry examples. Safety and quality monitoring procedures are also reviewed during this course. (30 hours)
In this course, students review a construction project, from bidding to construction. This course will examine typical situations encountered on a project and will address common pitfalls to avoid during a project. After completion of this unit, students will have a grasp of what it takes to complete a construction project. (30 hours)
Peter Tymus
With more than 30 years of knowledge in the construction industry, Mr. Tymus serves as Long Island University's Associate Vice President for Capital Projects.
Mr. Tymus has worked at Turner Construction Company in a variety of roles, including Assistant Engineer, Project Manager and Estimating and Purchasing Chief at Turner's Special Projects Division in New York. His clients include Dewey Ballantine Bushby Palmer and Wood; Coopers & Lybrand; Siemens Corporation; General Motors Corporation; Symbol Technologies; Mercedes Benz, N.A.; Lord & Taylor; Winthrop Financial Corp.; Bank of America; Irving Trust Corporation; American Bible Society; Deloitte & Touche; DASNY; CUNY; Longwood Central School District; Mount Vernon School District and Hallmark Corporation.
School of Professional and Continuing Studies
Location: Pratt 419
Phone: 718-488-1364
Fax: 718-488-1367
E-mail: email@example.com
Virtual Campus Tour
LIU Brooklyn Campus Life
Scholarships & Financial Aid
Bursar & Enrollment Services


text:
Getting the ID of external pages and display in loop or store in variable
I am creating a side bar navigation on a site that is pulling all the children of a page and displaying data from the posts as well as custom fields. I need to grab the ID of each of these pages and then store it in a variable so I can call the custom fields from each page. It does not matter I don't think but I am using the Advanced Custom Fields (ACF) plugin. If I can just get each page to even display each individual page ID I can then store that in a variable and I would be off and running.
I have tried using
get_the_id()in the loop but for some reason it is only grabbing and then duplicating the ID of the page I am on as I am on one of the said sub pages.
Have a look at the code in the following pastebin… http://pastebin.com/SBMjDTJY
I think the line of code that is giving me the trouble is probably 8 and 9. Line 6 is just a test line to see what ID is being spit out in that particular loop.
Thanks for any time and effort spent on this.
- The topic 'Getting the ID of external pages and display in loop or store in variable' is closed to new replies.


text:
The birth place of the Inca Civilisation and the capital of its mighty Empire, Cusco was once the most powerful city in the continent – rivalling great cities such as Rome, Athens and Cairo. Ancient chronicles depict a city of extravagant shrines, mighty palaces and gold lined temples. The fate of the city changed forever after the Spanish conquest in the 16th century. Nowadays, local Cusqueñans blend with the eclectic mix of passing tourists in the many cobbled streets around Plaza de Armas. Backpacking hostels through to high-end luxury properties; local eateries through to fine dining restaurants and endless bars and clubs dominate the vibrant and picturesque colonial centre. Cusco is one of South America's most interesting cities and one of the world's lesser known historic gems.
(Post Read – 19421)


text:
November 22, 2017
The lawyer behind Allergan's controversial transfer of patents to a Native American tribe said at the IP Dealmakers Forum that other companies are "lining up to do deals" and that universities' endowment funds are interested in getting involved. Shore outlined why he believed these types of deals are here to stay
WIPO Director General Francis Gurry says intangible capital determines success in the marketplace. "Intellectual property, in turn, is the means by which companies secure the competitive advantage flowing from their intangible capital"
November 21, 2017
IP practitioners see a trend of using confidentiality clubs in patent litigation cases to safeguard sensitive information, as demonstrated by the Delhi High Court's recent grant of such a request in a dispute between Ericsson and Xiaomi
November 17, 2017
Dorothy Whelan, co-chair of Fish & Richardson's post-grant practice group, has been involved in high-profile cases such as the first IPR decisions that invalidated Humira patents. As part of the Women in IP series, Whelan speaks to Michael Loney about the biggest issues at the PTAB
The Patent Trial and Appeal Board has revised the "Standard Operating Procedure 9 (SOP9)" for cases remanded from the Federal Circuit, including requiring panels to meet with the PTAB chief, deputy chief or a delegate to discuss remanded cases
November 16, 2017
The Federal Circuit has granted Micron's mandamus petition stating: "We conclude that TC Heartland changed the controlling law in the relevant sense: at the time of the initial motion to dismiss, before the Court decided TC Heartland, the venue defense … based on TC Heartland's interpretation of the venue statute was not 'available'"
The USPTO has released a final rule detailing fee increases to go into effect in January. The combined cost of an inter partes review request and institution at the Patent Trial and Appeal Board will go up to $30,500
November 15, 2017
Delhi High Court has been given eight weeks to finalise rules and practice changes to dispose with IPR suits faster, a move that is expected to benefit litigants
The Patent Court recently issued the first application of the UK Supreme Court's Actavis v Eli Lilly ruling. Arnold J considered the impact on novelty of the doctrine of equivalents
Overall success rates of motions to stay district court litigation pending review at the Patent Trial and Appeal Board have dropped noticeably in the past fiscal year. Christopher Hanewicz and Truscenialyn Brooks of Perkins Coie analyse recent stay statistics
November 14, 2017
China's ambitious initiative will likely lead to it being a hub for securing IP protection for businesses investing in Belt and Road Initiative projects. It will also affect enforcement strategies, with IP disputes expected to increase along the BRI route
November 09, 2017
The Patent Trial and Appeal Board has asked for amicus briefing on whether tribal ownership immunises a patent from IPR challenges, while a House of Representatives subcommittee held a hearing on sovereign immunity and the intellectual property system in which ranking member Jerry Nadler said Allergan's deal with a Native American tribe "makes a mockery of Congressional authority and of the rule of law"
A recent copyright win in New Zealand for rapper Eminem highlights the risks involved in creating a work with another work in mind, and may be influential in other Commonwealth jurisdictions like Australia and the United Kingdom
November 08, 2017
With the Madrid Protocol coming into force for Indonesia in January, IP practitioners observe potential delays to deal with international applications but are optimistic that time requirements under new trade mark law and an increase in the number of trade mark examiners can help
October at the Patent Trial and Appeal Board saw a levelling out of petition filing, the first ever extension of the final written decision deadline for good cause, and one precedential and three informative PTAB decisions
November 02, 2017
In another ruling demonstrating the difficulty for UK trade mark owners to protect their designs, the Court of Appeal has upheld a ruling that The London Taxi Company's trade marks are invalid. The case would present some interesting issues were it to be pursed to the Supreme Court
The Supreme Court's decision in Actavis v Eli Lilly introduced a doctrine of equivalents and arguably also established a doctrine of prosecution history estoppel in the UK. We look at the law across Europe, and the impact the decision might have. Kingsley Egbuonu, Michael Loney and James Nurton set the scene
A plan to launch a CRISPR patent pool has only attracted a few patent holders so far. Robyn Trigg and Marc Döring examine how it would work, and whether it will take off
A new bilateral agreement promises mutual recognition of certain geographical indications from Europe and China. Katharina König and Matthew Murphy explain
Erica Gould analyses a number of recent Cuban Trademark Office decisions issued in favour of US brand owners who had filed oppositions against applications made by trade mark pirates
Reforms are coming in Australia as the government responds to the Productivity Commission inquiry into IP arrangements. Karry Lai reports
The 2017 LMG Life Sciences Awards were held in New York in September
African countries have been keen to join the Madrid System, but Wayne Meiring reports that there remain problems in how it is implemented
How do US, UK and EPO tribunals compare when it comes to patent infringement disputes? Ilya Kazi contrasts tactics and procedures, drawing on lessons from recent cases
RT @mdloney: Michael Shore, the lawyer behind Allergan's controversial transfer of patents to a Native American tribe, vowed to "take a wre…
Our weekly IP news round-up includes stories about Finjan, Blue Coat, Fox Television, design patents, Polaroid, Fuj… https://t.co/dOtK14m74v
Confidentiality clubs becoming more common in Indian patent disputes https://t.co/VcVqY6V4CY The Delhi High Court r… https://t.co/qkhIzENcAw
October 2017
Courts grapple with scope of patent protection
The Supreme Court's decision in Actavis v Eli Lilly introduced a doctrine of equivalents and arguably also established a doctrine of prosecution history estoppel in the UK. We look at the law across Europe, and the impact the decision might have. Kingsley Egbuonu, Michael Loney and James Nurton set the scene
The material on this site is for financial institutions, professional investors
and their professional advisers. It is for information only. Please read our
Terms and Conditions
Privacy Policy
before using the site. All material subject to strictly enforced copyright laws.
© 2017 Euromoney Institutional Investor PLC. For help please
see our FAQ.
Switching to MIP International


text:
This product dispatches in 15-21 business days*. Conditions Apply*
This product dispatches in 2-4 business days*. Conditions Apply*
This product dispatches in 3-5 business days*.Conditions Apply*
Arriving soon, expected to dispatch by 1st Week on Jan'18.Conditions Apply*
MRP : Rs. 7,385.00
You Save : Rs. 560.00
Bajaao Price : Rs. 6,825.00
EMI starts from Rs. 369.69.
Click here for options.
Buy Mridanga Talam Digital Electronic Mridangam and Manjira online in India at the best price with free shipping from BAJAAO - India's music equipment superstore.
Mridanga Talam Digital Electronic Mridangam and Manjira
BAJAAO India introduces the Mridanga Talam Digital Electronic Mridangam and Manjira. For the first time Carnatic musicians both, professionals and students can now practice with the aid of an electronic Mridangam & Manjira. With over 200 talams with the Manjira mode and 40 variations in Mridangam and all that at variable speed, pitch and tempo. The 7 style digital balance and the Nadai & Jati selections adds a new flavor & dimension to this dynamic one of its kind electronic musical instrument. Since it's launch the Mridanga Talam has taken the Carnatic music fraternity by delight & given its students a new found confidence to practice & perform like never before.
Features and Specifications:
Technical Specifications:


text:
Brand Label: Lenox
51% ITEM DISCOUNT AT MACYS! WAS Pin It
Lenox Vintage Plaid Set/4 Bowls Home - Dining & Entertaining Tableware - Dinnerware.
Shop other brand label items from Lenox on FashionStylist.com.
This item was published for sale online by macys on September 4, 2017 1:38 pm and last updated by us November 15, 2017 10:46 am.
macys Note: This vendor may charge a fee of $10.95 for shipping and handling of this item. See website for further details and/or any volume discounts.
Editor Picks: 'The Homebody' Effortless Cool Stay at Home Syle
Sixth June Bomber Jacket
Paul Smith Kingsmill Oversized Sunglasses
To Boot New York Layton Suede Chukka Sneakers
Timo Weiland Colorblock Crewneck Sweater
Band Of Outsiders Varsity Sweater Wool Pullover
Editor Picks: Farfetch Vintage Collection
Gianfranco Ferre Vintage 1980s Long Dress
Chanel Vintage Oversized Braided Clip On Earrings
Yohji Yamamoto Vintage Slashed Collar Belted Jacket
Yves Saint Laurent Vintage 1996 Wrapped Skirt
Jean Paul Gaultier Vintage 100 Dollar Bill Print
Browse More Fashion Apparel by Lenox (view more)
- $28500.00
Lenox Emerald Diamond Dome Ring
- $24.99
Lenox Chirp Seasonal Salad Plate
- $329.99
Lenox Autumn Coffeepot With Lid Hat
- $53.00
Lenox Embroidered Boot Cut Denim Jeans Blue
- $49.95
Lenox Poppy Street Linen Two Tiered Server Tableware
- $50.00
Lenox Dinnerware Floral Fusion Kiwi 4 Piece Place
- $49.99
Lenox Butterfly Meadow Collection 2 Pc Lidded
- $49.99
Lenox Wave Low Bowl
- $169.99
Lenox Lakedale 72 Piece Flatware Set
- $29.99
Lenox Organics Ruffle Centerpiece Vase
New promo codes and links offering limited time promotions, sales coupons, and special offers on Lenox designer fashions and accessories will be posted on each designer label apparel page. For the latest up to date information on this Lenox Vintage Plaid Set 4 Bowls Dinnerware | Home fashion item, including product specifications, ordering options, pricing, shipping details, high resolution pictures, shopper comments, and other sales media, visit the macys Online Store.


text:
LK Advani, Uma Bharti, Murli Manohar Joshi To Stand Trial In Babri Masjid Demolition Case
Kalyan Singh enjoys Constitutional immunity as Rajasthan Governor and can be tried only after he ceases to hold office.
Get top stories and blog posts emailed to me each day. Newsletters may offer personalized content or advertisements. Learn more


text:
This product is well made and works perfectly for my kindle. I love the automatic off and on feature when you open/close the cover. I recommend this highly.Read More
Cheaply made. Ripped after one week. Did not work with my new Kindle paperwhite. The cover kept shutting down my reader. Very annoying. Buyer beware,Read More
I love this because it allows me to set it upright in a reading position so I don't have to hold it all the time. it also has the magnetic closure so it turns the kindle off when I close the cover and turns it back on when I open the cover. LOVE this cover.Read More
Good case, stand is handy, sturdy, well made. I would recommend it.Read More
Leather is poor quality. For over a month, every time I tried to read a book when the the kindle was in the cover, the reader only stayed on a page for 1-5 seconds and then it changed to advertisements. Very, very frustrating- could not read a book while it was inside the cover. The kindle did not do this when it was not in the cover. It finally stopped doing this.Read More
One of the most functional cases for Kindle, -- if you are an avid reader in multiple scenarios. Liked it so much this is my third one.Read More
I bought this for my husband for Christmas along with the Kindle Paperwhite. He loves it! It was a great little accessory without breaking the bank.Read More
Needed a substantial cover for my Kindle Paperwhite.. This cover really works well. It is faux leather in black only. It has a magnetic closure that turns off the Kindle when closed. It frames the Kindle reader well and has the necessary opening for the charging cable.. The only negative is the manner in which it opens--lengthwise instead of horizontally like a book. However, that said, it still was a great purchase at a reasonable price.Read More
although i was disappointed in not having a choice of color when i ordered, i did not realize how much i would like the ability to tilt the reader on a table. it may well be the most frequent way i read now, or nearly so. My other minor concern was that the case does not have a flap for holding papers but "not to worry"; since it shuts with a magnetic pull, you can keep any notes you may have from falling out anyway. this is a good product and certainly does its first job well which is to protect the kindle.Read More
product was as described but would have liked a different colorRead More
This cover does not work with my kindle paperwhite. The "on" button is on the bottom of the kindle and when you put the cover on it turns the kindle on. This is designed for the older version of the kindle. Returned - hoping for a refund.Read More
This is a great product, easy to use, keeps my kindle clean and the stand is great for holding up the kindle. The only thing that would add to it is if there was a small pocket on the cover .Read More
I was very pleasantly surprised by this product. I assumed that for a little over $10, I would be getting a cheap knock off. I had seen genuine Kindle cases for >$40 that didn't look quite as good and didn't have the features. I figured "what do I have to lose for that price?" Well, the description of this product does not do it justice... it could be a little better written. This is a great product, especially for the price. The quality is extremely good, nice stitching, seems like real leather. There are magnets embedded in the cover so that when you close it, the Kindle goes into standby mode and when you open it, it powers on. I really like the "kickstand"--I can sit at the table or counter at lunch and read my Kindle easier than I could have read a real book.! Love this case--highly recommend it.Read More
Decided not to use it due to the magnetic clasp. Would not recommend for that reason.Read More
I love this case for my new Paperwhite! It appears to be made very well. And I love the stand that is attached to it. Both of your hands are freed up! I actually bought 2 colors- the black one and a pretty, almost slate blue one which I love and get compliments on frequently. I might order another color !Read More
INSTEN Black Leather Phone Case Cover with Stand for Amazon Kindle Paperwhite
Today $6.99


text:
On Thu, Apr 17, 2003 at 07:45:03AM -0400, Norman Walsh wrote: > / "nate" <email@example.com> was heard to say: > | Norman Walsh said: > |> I'm trying to build 2.4.20 for my Compaq 7470 desktop machine. > |> At various times it's hung immediately after booting or after some agpgart > |> weirdness (197M? I don't think so). > | > | most likely bad ram > > Well, perhaps. I had some odd compile failures that a little > net-research suggested was bad ram. I ran memtest for several days > without finding anything. But a little more net-research suggests that > memtest doesn't find all the errors. Heh, gcc is sometimes a better memory tester than memtest... > In any event, I've swapped memory modules in, out, and around on this > box several times without any change in behavior. Known good RAM still causes problems? I'd bet on another source of hardware problems...loose connections, overheating, etc, etc...2.4.20 is supposed to be a stable kernel, I'd think it fairly unlikely that it crashes on boot like that only for you...:) -- Rob Weir <email@example.com> http://www.ertius.org/ GPG keys: 1024D/1E73B7CD, 4096R/3ABDE5EC | Do I look like I want a CC? Words of the day: Forte Qaddafi Blowfish Armani AGT. AMME MD2 UFO mailbomb
Description: PGP signature


text:
- This event has passed.
Breast Cancer – Homewood
December 7, 2016 @ 6:00 pm - 8:00 pm
Event Navigation
This is a drop-in monthly group for anyone with breast cancer to discuss treatments and coping mechanisms. Co-facilitated by a clinical therapist & Lisa Gravitt, RN, OCN, Palos Community Hospital


text: Yesterday (October 5th) i decided to head out to a set of reefs called the 24's (they are in 24 fathoms of water) and fish a big ball of bait that is "Always" there. Since they are "always" i didn't even bother brining any bait with me. The run out was a dream, not a wave around and i was able to jet out to the reef doing 25 knots - very unusual for my tiny boat. Unfortunately getting out there my bait ball is no where to be found<grr> Since it was so nice and the Marlin should be moving in i decided to cruise way out to the next set of reefs called the 36's....Not only was there no bait there was no fish sign on the finder either. Despite this i trolled big marlin lures around for the next 4 hours just out of sheer stubbornness... Coming home i did stop at the 18's and just to add injury to insult i proceed to catch Grinner after Grinner (a type of Large lizardfish that doesn't fight at all) maybe 15 before giving up in frustration and coming home...When i got back i found out some of the guys had been catching Spotted Mackerel really close in- oh well sometimes it just doesn't pay to go out! In either case while the fishing is slow now in the next couple of weeks the pelagics should start moving and since i did see some bait schools at the mouth of the sea way I am hoping for a monster marlin season!


text:
|Home | About | Journals | Submit | Contact Us | Français
ABCC1 is a member of the ATP-binding Cassette super family of transporters, actively effluxes xenobiotics from cells. Clinically, ABCC1 expression is linked to cancer multidrug resistance. Substrate efflux is energised by ATP binding and hydrolysis at the nucleotide-binding domains (NBDs) and inhibition of these events may help combat drug resistance. The aim of this study is to identify potential inhibitors of ABCC1 through virtual screening of National Cancer Institute (NCI) compounds. A threedimensional model of ABCC1 NBD2 was generated using MODELLER whilst the X-ray crystal structure of ABCC1 NBD1 was retrieved from the Protein Data Bank. A pharmacophore hypothesis was generated based on flavonoids known to bind at the NBDs using PHASE, and used to screen the NCI database. GLIDE was employed in molecular docking studies for all hit compounds identified by pharmacophore screening. The best potential inhibitors were identified as compounds possessing predicted binding affinities greater than ATP. Approximately 5% (13/265) of the hit compounds possessed lower docking scores than ATP in ABCC1 NBD1 (NSC93033, NSC662377, NSC319661, NSC333748, NSC683893, NSC226639, NSC94231, NSC55979, NSC169121, NSC166574, NSC73380, NSC127738, NSC115534), whereas approximately 7% (7/104) of docked NCI compounds were predicted to possess lower docking scores than ATP in ABCC1 NBD2 (NSC91789, NSC529483, NSC211168, NSC318214, NSC116519, NSC372332, NSC526974). Analyses of docking orientations revealed P-loop residues of each NBD and the aromatic amino acids Trp653 (NBD1) and Tyr1302 (NBD2) were key in interacting with high-affinity compounds. On the basis of docked orientation and docking score the compounds identified may be potential inhibitors of ABCC1 and require further pharmacological analysis.
ABC - ATP-binding cassette, DHS - dehydrosilybin, MDR - multidrug resistance, NBD - nucleotide-binding domain, PDB - protein data bank.
Multidrug resistance (MDR) imposes a serious constraint on successful treatment of cancer. A major factor contributing to MDR is overexpression of efflux transporters of the ATPbinding cassette (ABC) superfamily, which act as energydependent drug efflux pumps [1–3]. Anticancer drugs within the major categories of chemotherapeutics, including vinca alkaloids, anthracyclines, epipodophyllotoxins and folate-based antimetabolites [4] are ABCC1 substrates and high levels of ABCC1 expression has been associated with poor clinical outcome in the treatment of retinoblastoma and neuroblastoma [5, 6]. ABCC1 expression can also affect the response of nonsmall cell lung cancer [7], breast cancer [8–10], and ovarian cancer [11] to chemotherapy. ABCC1 is a 190-kDa glycoprotein consisting of 2 nucleotide-binding domains (NBDs) and 3 transmembrane domains [12–14]. ABCC1-mediated substrate translocation to the cell exterior is energised by ATP binding and hydrolysis at the NBDs [15, 16]. Since ATP binding and hydrolysis are fundamentally important to active drug efflux, targeting agents to the NBDs to disrupt the catalytic cycle is a potential strategy for addressing ABCC1-mediated cancer multidrug resistance. In vitro studies reveal that naturally occurring flavonoids (e.g. in fruits, vegetables, tea), bind to recombinant ABCC1 NBDs [17]. Therefore, in this study, flavonoids and flavonoid-based compounds were used as input ligands for pharmacophore generation to identify potential modulators of ABCC1 NBDs using both ligand (pharmacophore)- and structure (molecular docking)-based approaches.
The library of compounds for screening against the ABCC1 transporter was obtained from the National Cancer Institute (NCI) database in SDF format from http://cactus.nci.nih.gov/download/nci. NCI compounds were prepared for screening using the LigPrep process (Schrodinger Suite 2009, Schrodinger LLC NY). The ligands were parametised using OPLS_2005 force field and tautomers and ionisation states expected to occur between pH 5.0 and 9.0 [18, 19]. Following energy minimisation, the total number of compounds generated was 309,520. Compounds demonstrating good drug-like properties i.e. predicted high oral bioavailability and potentially low toxicity, were selected using the QikProp filter based on the modification of Lipinski's rule of five [20, 21]. This step yielded a total of 167,350 potential drug-like compounds.
The pharmacophore hypotheses for ABCC1 NBD1 and ABCC1 NBD2 were constructed using the basic structures of flavonoids known to interact at each NBD (Genistein, Apigenin, Naringenin, Galangin, Quercetin, Dehydrosilybin (DHS), Silybin, 6-prenyl DHS, 6-geranyl DHS, 8-prenyl DHS, 8-geranyl DHS) [17]. The biological activities were reported as dissociation constants (KD), which were subsequently converted to pKD (–log (KD)) for each NBD. Pharmacophores were generated using PHASE (Pharmacophore Alignment and Scoring Engine) software, version 3.1, 2009 (Schrodinger Suite 2009, Schrodinger LLC NY) [22].
To identify the best-optimised hypothesis for pharmacophorebased screening, all hypotheses for ABCC1 NBD1 and ABCC1 NBD2 were subjected to an analysis scoring function (survival score). Compounds identified from the 167,350 drug-like compounds were required to match at least five pharmacophoric features to be considered appropriate for structure-based molecular docking studies, with distance tolerances for pharmacophoric features set at 2 Å.
Homology modelling was used to construct the threedimensional model of ABCC1 NBD2 using template amino acid sequences of ABC transporters for which X-ray crystal structures are available. An X-ray crystal structure of ABCC1 NBD1 (PDB code: 2CBZ) is available in the protein data bank (PDB) [23]. The full-length human ABCC1 protein sequence (ID: P33527) was obtained from the National Centre for Biotechnology Information (NCBI). The amino acid sequence of the C-terminal NBD of ABCC1 (Arg1292 – Asp1527) was subsequently extracted as a target sequence. Template sequences homologous to the ABCC1 NBD2 sequence were retrieved using a BLAST search. An amino acid multiple sequence alignment of ABCC1 NBD2 and the five protein templates was generated using ClustalW [24]. The Espript programme was used to generate secondary structures of the five templates [25]. ABCC1 NBD2 homology models were generated using Modeller 9 version 7 [26]. Stereochemical analyses of the refined models were carried out using Ramachandran plots by molprobity website [27]. Refined models were subjected to 1000 energy minimisation steps using GROMACS (Version 4.0) [28].
Prepwizard was used to assign bond orders, add hydrogen atoms and delete water molecules for ABCC1 NBD1 (X-ray crystal structure) and NBD2 (homology model). Energy minimisation was implemented using OPLS_2005 forcefield (Schrodinger Suite 2009, Schrodinger LLC NY). Compounds identified using pharmacophore-based screening were docked into ABCC1 NBD1 and ABCC1 NBD2 using Glide (Grid-Based Ligand Docking with Energetics) software package v5.5 [29]. In this study, initially standard precision (SP) docking was carried out and ligand conformations demonstrating the highest scores (i.e. top 10% of docking scores) were subsequently redocked using the extra precision (XP) docking algorithm to obtain high quality refinement ligand poses. Visualisation of ligands was carried out by the Maestro graphical interface.
A total of 5,953 hypotheses were constructed for ABCC1 NBD1 and 6,505 for ABCC1 NBD2. Each hypothesis possessed five pharmacophoric features categorised as AADDD, AAADR, AAADD, AAAAD, AAAAR AADRR, AAARR, AADDR, or ADDRR (A, hydrogen bond acceptor; D, hydrogen bond donor; R, aromatic ring).
For ABCC1 NBD1, the best-optimised hypothesis was AADRR.65 (survival score: 5.952). The spatial distribution of pharmacophore sites was two aromatic rings (R1 and R2), whose centres were separated by 6.463 Å (Figure 1A). The rings mapped to ring A and B of flavonoids (Figure 1B). Two H-bond acceptors, A1 and A2 (Figure 1A), were separated by 4.115 Å; A1 mapped to the oxygen atom at position 1 of flavonoids, whereas A2 mapped to the oxygen atom of the carbonyl group at ring C of flavonoids (Figure 1B). The H-bond donor D1 was located adjacent to H-bond acceptors A1 and A2 at a distance of 3.699 Å and 5.662 Å, respectively (Figure 1A). D1 mapped to the hydrogen atom of the hydroxyl group at position 5 of ring A of flavonoids (Figure 1B).
The best-optimised pharmacophore hypothesis for ABCC1 NBD2 was AADRR.1277 (survival score: 5.955). AADRR.1277 possessed two aromatic rings, R1 and R2 separated by 6.463 Å (Figure 1C), which mapped to rings A and B of flavonoids (Figure 1D). The hydrogen bond donor D1, 3.257 Å from the centre of R1, was allocated to the hydrogen atom at position 5 of ring of flavonoids (Figure 1D). Two H-bond acceptors, A3 and A4, were separated by 2.830 Å and mapped to the oxygen atoms at positions 3' and 4' respectively of ring B of flavonoids (Figure 1D).
AADRR.65 (NBD1) and AADRR.1277 (NBD2) exhibited partial structural similarity with each other, in terms of positions of the R1 aromatic rings and R2 aromatic rings, (Figure 1, R1 and R2 of each pharmacophore). These pharmacophoric features mapped precisely to rings A and B of flavonoids (Figure 1B (NBD1), Figure 1D (NBD2)). There was also consistency between the position of the H-bond donor feature in each pharmacophore (Figure 1A, D1 and Figure 1C, D1) and the location of the Hbond donor at position 5 of ring A of flavonoids. These findings reflect the basic characteristic structural features of flavonoids (i.e. rings A and B) reported to inhibit ABCC1 activity in vitro [30–33]. Tawari et al. (2008) generated an ABCC1-targeted pharmacophore, based on non-flavonoid-like pyrrolopyrimidines and indopyrimidines, that was validated using compounds with high potency against ABCC1, including dehydrosilybin. The aromatic ring feature (Figure 1, R1) of AADRR.65 and AADRR.1277 was also present in the pharmacophore generated by Tawari et al. (2008), as was the hydrogen bond acceptor feature (A2) in ABCC1 NBD1 (Figure 1) [34]. Pharmacophore-based screening of the NCI database with AADRR.65 and AADR.1277 identified 3,163 and 1,113 hit compounds respectively.
Sequences homologous to ABCC1 NBD2 were retrieved using a BLAST search filtered for known 3D structures. The Escherichia coli haemolysin B NBD (PDB code: 1MT0) [35] demonstrated highest sequence identity, 37%, with ABCC1 NBD2 whilst Salmonella typhimurium MsbA (PDB code: 3B60) [36] and Plasmodium yoelii MDR protein 2 (PDB code: 2GHI) [37] both demonstrated 36% sequence identity. The bacterial ABC transporter Sav1866 (PDB code: 2HYD) [38] and the Lactococcus lactis ABC transporter NBD (PDB code: 1MV5) [39] possessed 35% and 34% amino acid identity respectively. Multiple sequence alignment of human ABCC1 NBD2 with the structural template sequences demonstrated the highly conserved regions within the proteins, namely the Walker-A and –B motifs, Signature sequence, Q-loop, D-loop and H-loop (Figure 2).
The ABCC1 NBD2 homology model is comprised of Arm I and Arm II which together possesed ten β-sheets and ten α-helices (Figure 2) consistent with the secondary structures of the template sequences. Arm I, the ABC-β subdomain, is composed of nine β-sheets and two α-helices containing the conserved P loop, Walker B, H-loop and D-loop sequences. The P-loop sequence is located within a linker region between β3 and α1 and the Walker B sequence is localised in β7. Arm II represents the ABC-α subdomain and contains eight α helices (α3-α10) with the Signature sequence (C-motif) located at α6 of the ABC- α subdomain. The homology model with the highest percentage of amino acids within the favoured regions, 97.9%, and allowed regions, 99.6%, as identified by Ramachandran plot analysis, was used in subsequent docking studies. Within the homology model only a single amino acid, Asp1389, was not within the allowed region.
The ligand conformation possessing the lowest docking score is representative of a conformation with favourable binding energy (i.e. high binding affinity). The docking scores of compounds docked into ABCC1 NBD1 (using XP docking mode) ranged from -7.33 to 0.77. Approximately 5% (13/265) of these compounds possessed a lower docking score than ATP (- 6.19), suggesting they may bind with a higher affinity compared to ATP. Docking studies of these compounds, NSC93033, NSC662377, NSC319661, NSC333748, NSC683893, NSC226639, NSC94231, NSC55979, NSC169121, NSC166574, NSC73380, NSC127738 and NSC115534, within ABCC1 NBD1 revealed a propensity for them to be partially accommodated in the ATP binding site within the binding cavity. The oxygen and hydrogen atoms of the above compounds were predicted to form extensive hydrogen bonds with Gly681, Lys684, Ser685 and Ser686 within the P-loop. Hydrophobic interactions were also identified between the compounds and the aromatic amino acid Trp653 (Figure 3).
The predicted docking score of NCI compounds docked into the homology model of ABCC1 NBD2 ranged from -7.36 to - 1.60. Approximately 7% (7/104) of these compounds were predicted to possess a lower docking score than ATP (ATP docking score; -6.17), and may bind with relatively high affinity to the NBD. These compounds were NSC91789, NSC529483, NSC211168, NSC318214, NSC116519, NSC372332 and NSC526974. The predicted docking orientation of the highaffinity compounds within ABCC1 NBD2 overlapped with that of ATP and the oxygen atoms and hydrogen atoms were predicted to form a network of hydrogen bonds with Lys1333, Ser1334 and Ser1335 within the P-loop. Hydrophobic contacts stabilised the interaction with the aromatic amino acid Tyr1302 (Figure 3).
The predicted ATP-binding site is a narrow pocket which restricts the binding orientation of selected NCI compounds, i.e. restricted along a site defined by aromatic residues (Trp653 in NBD1) and Tyr1302 in NBD2) and the P-loop cavity. Our studies have shown that Trp653 (NBD1) and Tyr1302 (NBD2) are significant for ligand-binding since, in both NBDs, they interact with hydrophobic moieties of compounds with predicted high-binding affinity. Importantly, NCI compounds with predicted low binding affinities (high docking scores) demonstrated fewer or no hydrophobic interactions with these key aromatic amino acids (data not shown). These findings are consistent with the important stabilising hydrophobic interactions reported between the adenine ring of ATP and Trp653 (NBD1) and Tyr1302 (NBD2) in ABCC1 [40]. The P-loop in both NBDs was predicted to be the main site for hydrogen bond interactions between docked NCI compounds and ABCC1 NBDs. This is expected since the P-loop region contains a large proportion of polar amino acids and is the well-recognised site of hydrogen bond interaction between the phosphate groups of the endogenous ligand ATP and NBDs [16, 35, 41]. In addition, this finding is supported by the study of Badhan (2006) in which the in silico interaction of flavonoids with ABCB1 (Pglycoprotein) NBD2 reports the 3-hydroxyl and 5-hydroxyl groups and carbonyl oxygen are involved in hydrogen bonding with the P-loop [42].
Currently, flavonoid-based compounds are the only group of chemical structures reported to modulate ABC transporters by binding to NBDs [17, 43–45]. Our studies show all screened NCI compounds possessed the pharmacophoric features of flavonoid-based compounds as the primary chemical scaffold. Although some hits differed structurally from flavonoid-based compounds, they possessed the same pharmacophoric features and predicted molecular interactions within ATP-binding sites, namely hydrogen bonding at the P-loop and hydrophobic interactions at aromatic acid residues (Trp653 in NBD1, and Tyr1302 in NBD2).
We have identified compounds from the NCI repository predicted to bind with high affinity at the ATP-binding sites within the ABCC1 efflux transporter. These compounds may show potential as modulators of the catalytic cycle of ABCC1 and consequently could inhibit ABCC1 transporter-mediated drug efflux.
Financial support from the University of Manchester Overseas Research Studentship Award Scheme (ORSAS) and the School of Pharmacy and Pharmaceutical Sciences is gratefully acknowledged.
Citation:Rungsardthong et al, Bioinformation 8(19): 907-911 (2012)
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
Kathmandu, Sept 26: Baburam Bhattarai, Nepal's former prime minister and top Maoist leader sympathetic to Madhesis, today resigned as lawmaker and also quit the party to form his own political "force" amid differences with the major Nepalese political parties over the new Constitution.
Bhattarai, a veteran leader of the Unified CPN-Maoist, was the senior-most leader after party chief Pushpa Kamal Dahal, popularly known as 'Prachanda'.
Bhattarai, who spent his years as a student at New Delhi's Jawaharlal Nehru University and is said to have close links with India, has been sympathetic to the agitation launched by Madhesi parties demanding more rights and representation to the people residing in the southern plains of Nepal.
He has consistently attacked lawmakers, including members of his own party, for not taking minorities' concerns into account during the drafting of the new Constitution -- Nepal's first by elected representatives.
The 61-year-old leader has indicated that he would form a new political "force" within a couple of months. "Effective from today's date I have resigned from all obligations, responsibilities at all levels as well as general membership of the UCPN Maoists," Bhattarai told reporters.
Read More: India not blocking trade with Nepal: Envoy
"I will now do what I can as a citizen of this country... as long as I am alive I will work for the country and the people," he said. He also appeared to distance himself from the Maoist ideology and said Maoism has become irrelevant and obsolete in today's world.
He has indicated that his new party would be democratic in nature. Bhattarai's decision has given a big jolt to the UCPN-M as he leads a strong faction within the party, say insiders. The UCPN-M has 124 seats in the 601-member Parliament.
Party sources say nearly half of the Maoist lawmakers are likely to toe Bhattarai's line. During a press conference, Bhattarai said he would visit cities in the troubled Terai region, some of which are close to the Nepal-Indian border, in a few days to understand the situation there.
Bhattarai will visit Biratnagar, Janakpur, Nawalparasi and Nepalgunj in southern Nepal. But he would first visit Janakpur on Tuesday, his close aides said.
The Terai region (plains) has been on the boil since the new Constitution was debated. The Madhesis, Indian-origin inhabitants of the plains, are up against the new charter, alleging that it doesn't protect their rights and interests.
The ethnic Tharu community say the model of splitting Nepal into seven provinces leave them under-represented in the country's Parliament. More than 40 people have died in the ensuing protests over the new Constitution. Bhattarai, who led the second Maoist government between 2011 and 2013, was one of the key figures behind Nepal's civil war that killed nearly 17,000 people. He was the vice chair of the UCP-M that fought a decade long war to topple the monarchy in Nepal.


text:
Pet Bots V 1.3.1 for Android 4.0.3+ Pet Bots is a FRESH spin on the predictable endless runner genre. Guide the Pet Bots on their noble journey for a better tomorrow. Help them them pass the test of agility by avoiding spikes and getting crushed.
Oh no! People over the world played too much ENERGY CONSUMING VIDEO GAMES. There is no electricity left! PET BOTS are coming to the rescue of the human race. Take control of the Pet Bots and show the world what they can do.
Pet Bots features:
– TRIUMPH over 60 thumb breaking CHALLENGES with plenty more to come
– CUSTOMIZE your JETS to help you finish even the hardest challenges
– RETURN THE LIGHTS to each part of the city and deal with the unfortunate consequences of your actions
– BUILD your collection of Pet Bots
– ENDURE over 70 LETHAL OBJECT formations
– ENJOY stunning sci-fi, futuristic setting HAND DRAWN by Sergei Usatov
– EXPERIENCE innovative THROWING controls
– original DOUBLE PHYSICS (water + gravity)
– Easy to learn, HARD to master
– CLIMB the LEADERBOARD and stalk your friends and foes
– use FACEBOOK to bring along your friends for the ride. Help them or LOCK HORNS with them. The choice is yours!
– TAKE CONTROL of various cats, aliens, pets, robots
Pet Bots is completely FREE to play, the in–game currency can be purchased with real money but it's NOT REQUIRED to advance in the game (NOT PAY TO WIN).
Like the game? Like us on Facebook
if there is any problem please let us know. Write your problem in comment box below.
Editors Notes:
Very fun game, I'm addicted to this game, it is very interesting, it is worth the download.


text:
Manufactured by Ultimate Sports Nutrition
|Sort by
|View: 1-11 of 11 items
Allegro ID: 585158
Allegro ID: 583682
Allegro ID: 583683
Allegro ID: 583200
Allegro ID: 583201
Allegro ID: 583202
Allegro ID: 583203
Bottle of 60
Allegro ID: 583842
Allegro ID: 583949
Bottle of 90
Allegro ID: 583545
Allegro ID: 583200
|View: 1-11 of 11 items
|Pages: 1
Because our price on this item is lower than the manufacturer's suggested retail price, the manufacturer does not allow us to show you our price until you place the item in your shopping cart. Retailers like Allegro Medical have the legal right to sell products at prices we set. However, adding the item to your cart allows us to show you our lower price consistent with our promise of always offering you the lowest possible prices on the widest selection of medical supplies, medical equipment and life enhancing products.
Adding this item to your shopping cart won't require you to buy it. However, our prices do change. If you decide to purchase this item now you are guaranteed the price now displayed in your shopping cart. Complete your purchase by clicking on the "checkout" button or simply remove the product from your cart if you decide not to make your purchase at this time.


text:
A sweet mug cozy and cardhttps://folksy.com/items/6976937-Knitted-Plum-Mug-Cozy-with-Flowers-and-Free-Birthday-Card
This hand painted oystercatcher pebble - would look lovely propped up on someone''s mantlepiece or shelf
I've posted 2 of my Activity Bags today
My 'Winter Chestnut Tree';
I listed this which is very appropriate seen as it's the month of March.
A quilted patchwork holdall
An original hand painted whale picture on a pebble, made into a necklace:
Today's listing , a pretty shade of pink shell pearl and faceted clear quartz. Perfect gift for Mother's Day .
Here's mine todayhttps://folksy.com/items/6621429-Mother-s-Day-Greeting-Card-Nana-Crystal-Heart-Design-Handmade-Card
Just listed this beautiful pink shell pearl necklace. Perfect for Mother's Day, comes in a gift box.
Cat brooch
More Figures in my Sale/Clearance.


text:
- 09 Sep, 16
- by Anna Brones
- in Features
- 0
- 6
A Look Inside Comestible: Volume 2
Earlier this year, I launched Comestible, a small print publication. Think of it like Foodie Underground in print, a publication devoted to food, the places it comes from and the people who grow it. If Foodie Underground has been a little quiet for the last few months it is because a lot of energy has producing Comestible. A reminder that print takes time.
The second edition is dedicated to origin, particularly the origin of some of our favorite (often exotic) foods: coffee, chocolate and wine. I was honored to have three very talented writers take on these three topics.
Eileen P. Kenny brings us to the homeland of coffee, Ethiopia, with Simran Sethi we explore the world of chocolate and winemaker Emily Towe leads us on a journey of natural wine, taking a look at producers who are challenging conventional winemaking norms (which involve a whole lot more additives than you ever thought).
Breaking out of the "edible" box, there's also an essay by Sasha Duerr of the origin of dyes, in this case, plant dyes. I think there is a lot of crossover between the worlds of food and fiber and this is one of them. Duerr also includes a recipe for dyeing with wild fennel. Eat it and wear it!
There's all of this and a whole lot more, so if you feel like your bookshelf needs a copy of Comestible (trust me, it does!) you can snag a copy here.
And remember, all the contributors to Comestible are paid; with your purchase you are supporting working writers and artists!
Summer Squash and Nasturtium Leaf Salad
Late Summer Cilantro and Tomato Bruschetta (for Outdoor Enthusiasts)


text:
Agency: J. Walter Thompson
Location: New York, NY
Website: http://www.jwt.com
Twitter: @JWTNY
Instagram: @jwtworldwide
J. Walter Thompson Worldwide, the world's best-known marketing communications brand, has been creating pioneering solutions that build enduring brands and business for more than 150 years. Headquartered in New York, J. Walter Thompson is a true global network with more than 200 offices in over 90 countries, employing nearly 10,000 marketing professionals. The agency consistently ranks among the top networks in the world and continues a dominant presence in the industry by staying on the leading edge—from hiring the industry's first female copywriter to developing award-winning branded content today. For more information, please visit www.jwt.com and follow us @JWT_Worldwide.
Top 3 Interesting Facts a #MAIP2017 Fellow Won't Find on the Agency's Website?
- We have a game room onsite.
- We have a soft ball team.
- We are the very first advertising agency...ever.


text:
Green Smile is a consulting agency in agriculture that was created in May 2009. Our purpose is to support your farming business in its move towards a rational management. Through our experience as growers, we will bring to your business tailor-made solutions to enable it to face a highly competitive market.
- Error
Who are we?
- Details
- Written by Green Smile


text:
Don't miss your chance to see Kenny Rogers in Knoxville! Check out the schedule below for the concert date of your choice, then buy your Kenny Rogers Knoxville tickets before they sell out!
Looking for Kenny Rogers tickets in other cities? View all Kenny Rogers tickets »
Sorry! We couldn't find any events for Kenny Rogers in Knoxville.
If you were searching to see if Kenny Rogers is coming to Knoxville, then you're in luck! For their latest tour, Kenny Rogers will indeed hold a concert in Knoxville. Have an awesome concert experience when you go to see Kenny Rogers in Knoxville. Get your Kenny Rogers tickets Knoxville and join fellow fans for a concert to remember!


text:
Kendall County eyes new jail, sheriff's office, larger EMS officeMarch 23, 2015
BOERNE — Kendall County voters may cast ballots in November on whether to spend roughly $20 million to build a 96-bed jail and new sheriff's offices beside the current law enforcement facilities on Staudt Street.
To continue reading this story, you will need to be a digital subscriber to ExpressNews.com.
By logging in, you agree to the Terms and Conditions and Privacy Policy.


text:
|22 Feb 2014
Thanks for everyones help. Although im wondering how it occurred in the first place... Can a BSOD corrupt drivers?
Also I still wish to test my hard drives too, out of the diagnostic tools on this page which ones should i use for my seagate and samsung hard drives?
Hard Drive Diagnostics Tools and Utilities (Storage) - TACKtech Corp.
|My System Specs
|23 Feb 2014
I think it's corrupt driver cause BSODs, however I don't know why they get that way.
For the HDD tests I would use the Sea Tools by Seagate, they now own Samsung's HDD division.
|My System Specs
|25 Feb 2014
|My System Specs
|28 Feb 2014
Some good news at any rate, mate. The cursor issue may be USB driver, battery, if it's wireless, poor mouse pad or bad mouse. A dirty LED or laser lens too.
|My System Specs
|29 Mar 2014
Unfortunately, the problem has returned with a vengeance, and reinstalling the audio driver does not seem to fix it so now its a new problem.
After running seagate tools only 2 of my 3 hdds passed the long generic test, i cant tell if which drive failed the test, its one of the samsung ones but i cant find its full name anywhere in device manager. Apparently its serial number is listed, is it also labelled somewhere on the HDD itself? What should i do from here if it IS causing my problem? (i dont think its my OS HDD)
|My System Specs
|29 Mar 2014
Google the serial number to determine which HD it is.
These drives should be tested while plugged in individually using Seagate Seatools extended CD test, followed by a full Disk Check. Replace any failing drives.
|My System Specs
|29 Mar 2014
Google the serial number to determine which HD it is.
These drives should be tested while plugged in individually using Seagate Seatools extended CD test, followed by a full Disk Check. Replace any failing drives.
|My System Specs
|29 Mar 2014
Use the Seagate DOS download so that you boot to run the Extended test from CD.
Unplug all other HD's except the one being tested.
Back up all data and a Win7 image now. All data should always be backed up if it is valued at all.
|My System Specs
|29 Mar 2014
|My System Specs
|01 Apr 2014
Ok. The OS hard drive is the one failing the long test. However i did the previous tests with furmark n such arent freezing or anything so it could be the drive just going off.
Anyway i rang seagate, they can replace but they will give me a low format refurbrished one or something along those lines, and they cant clone my drive.
So i want to keep everything on this drive exactly the same, my registry,documents, web browsing history, etc.
Could i make an image and then install the image on the hard drive they send to me to make it exactly like this hard drive that im going to send off?
What app would you recommend for making an image? (the image would probably be about 400gb) because the OS hard drive has about 534/934 GB left
|My System Specs
|Thread Tools
|Similar help and support threads
Error code 0xc000000d in event viewer. Causing computer to shut down?
Hello, Recently my computer has been shutting down without warning. I could be doing anything from playing far cry 4 to browsing the web. I looked into the event viewer and found the following error: 0xc000000d. I've looked into it but it sounds like everyone else who has that same issue can't...
|BSOD Help and Support
Computer keeps restarting at random times. Event viewer report in post
My computer keeps restarting at ramdom time during the day. If I play a movie using vlc that restarts it every time. I tried running Linux to see if it was a windows problem and still happend. Tried running memtest and it goes into a infinite restart loop after 15 sec in memtest. I swapped out ram...
|BSOD Help and Support
Computer randomly restarting, no useful information in event viewer
For the past few weeks my computer has been randomly restarting. It is more common when I'm playing a game. I originally thought that my processor was hitting the shut down temp I set in bios, but I started recording the temp and the time after that it shut down, that temp was never reached. The...
|General Discussion
Event viewer log showing login times when computer is off
I have noticed that my event viewer log is showing successful logins when my computer is off. Is this normal? Does the system ever "log itself in" while its off?
|Performance & Maintenance
Computer Hard Freezes with No BSOD or Event Viewer Logs
Howdy everyone. I've got a problem with my computer hard freezing (locking up, no input, have to perform a hard reboot) since July 15th. It seems impossible for me to diagnose this problem since I've never dealt with a recurring hard freeze before. My initial reaction was that the hardware was...
|BSOD Help and Support
Computer locks up playing several games KERNEL ERROR in event log
Dell XPS 9100 with Windows 7 pro X64. Dell support is no help, they just keep saying it is a software issue because their boot diagnostic doesnt show any problems. It quite often makes me do a system restore before i can get back into windows after it happens. Event log says Critical type,...
|BSOD Help and Support
|Our Sites
|Site Links
|About Us
|Find Us
Windows 7 Forums is an independent web site and has not been authorized, sponsored, or otherwise approved by Microsoft Corporation. "Windows 7" and related materials are trademarks of Microsoft Corp.
© Designer Media Ltd
All times are GMT -5. The time now is 09:10.


text:
The Little Bit Foundation supports dozens of schools across the Metro. Now, it's helping one more school: Gibson Elementary. Students celebrated their new relationship with the Little Bit Foundation with an assembly Wednesday.
"Our schools need Little Bit Foundation," fourth grader Sekia Howard said. "We need support and we need help."
After the assembly, the foundation gave each student two free books. Little Bit Foundation co-founder Rosemary Hanley says, moving forward, kids will also have access to other resources they may need to succeed, from clothing to counseling.
"When a child has the eye glasses they need or the medical care or their bellies are full, clean clothes, we have a more focused learning environment," Hanley said. "We have a more focused student."
It's an initiative she and school leaders call Project Graduation. They say the additional resources should help increase graduation rates.
"We want to surpass the national average as well as the state average and we believe that through this partnership with Little Bit Foundation, we can do just that," said Chaketa Riddle, assistant superintendent of student support services.
A lot of the students believe it, too. During the assembly, they raised their hands to show they plan on graduating high school. Some are already thinking about college.
"I want to go to Yale University," Howard said.
It turns out the school district and the Little Bit Foundation aren't the only ones behind Project Graduation. There's a third party involved, too. An anonymous donor has pitched in $250,000. Project Graduation aims to match that amount this year through community donations.
"What Riverview Gardens believes, what Little Bit believes, and what this anonymous donor believes, is it is a community effort. It takes everyone to make a difference."
The Little Bit Foundation plans to support all schools within the Riverview Gardens School District over next three years.


text:
sort by best latest
Self-sabatoge because they aren't confident about their abilities to do the job. Or, they really don't want to be there anymore and become passive-aggressive. A more conscious reason that may be tied in and worth mentioning is that in order to collect unemployment, you have to be fired.
You can help the HubPages community highlight top quality content by ranking this answer up or down.
Great answer!


text:
Reuters Staff
1 Min Read
May 2 (Reuters) - Anhui Xinhua Media Co Ltd
* Says controlling shareholder plans to add up to 2 percent stake in the company within six months
Source text in Chinese: bit.ly/2pryvmS
Further company coverage: (Reporting by Hong Kong newsroom)
All quotes delayed a minimum of 15 minutes. See here for a complete list of exchanges and delays.
© 2017 Reuters. All Rights Reserved.


text:
Committee Leaders Continue Investigation Into Health Law, Concerned with Security Testing of Exchange, Protection of Consumer Information
The Subcommittee on Oversight and Investigations, chaired by Rep. Tim Murphy (R-PA), has scheduled a hearing for Tuesday, November 19, 2013, at 10:15 a.m. in room 2123 of the Rayburn House Office Building. The hearing is entitled "Security of HealthCare.gov." Witnesses to be announced.
House Energy and Commerce Committee leaders recently sent letters to Health and Human Services Secretary Kathleen Sebelius and four government contractors involved with implementation of the exchanges regarding rising security concerns surrounding the Federally Facilitated Marketplace. In addition to HHS, the committee requested documents and information from Creative Computing Solutions, Inc., Foreground Security Inc., MITRE Corporation, and Verizon Terremark.
Full committee Chairman Fred Upton (R-MI) and Subcommittee Chairman Murphy commented, "It is critical that the administration do everything in its power to protect Americans' sensitive personal information. And yet, despite hundreds of millions of taxpayer dollars spent on a website that is still not fully operational, more concerns are being raised each day about the security of HealthCare.gov. Americans deserve the peace of mind that their personal information will be safe, but the administration has yet to demonstrate they are capable or competent to deliver."
During an October 30 hearing with Secretary Sebelius, committee member and Chairman of the House Intelligence Committee Mike Rogers (R-MI) submitted for the record a document signed by Centers for Medicare and Medicaid Services Administrator Marilyn Tavenner that states "Due to system readiness issues, the [Security Control Assessment] SCA was only partly completed. This constitutes a risk that must be accepted and mitigated to support the Marketplace Day 1 operations." The memo explains, "there are inherent security risks with not having all code tested in a single environment."
The Majority Memorandum, a witness list, and witness testimony will be available here as they are posted.


text:
Photo © Rajesh Changela
And the caption was as follows:
"Unlike most US Airports, German Airports are renowned for being enthusiasts friendly. Developers of MUC even built the giant pyramid for just the viewing/spotting for airplane enthusiasts."
Now I know the viewing areas at Hamburg is excellent, I experienced that first hand, and if what Airliner world magazine writes is to be believed then Frankfurt spotting deck is the countries second most visited tourist attraction - so it must be good but is this 'pyramid' really for spotters or am I just so lame I didn't get the joke?
If it is for spotters, is it any good because Munich was on my want to list for when I next go to Germany.
Best Regards


text:
OTTAWA, Ontario, June 8, 2016 /PRNewswire/ -- The Board of Directors of VMS Rehab Systems Inc. reported today that its generic drug unit BioPharmcor B.V., launched this week its first private placement of class A voting shares. The Offering which has priced BioPharmcor B.V. ordinary A shares at eurocents 0.75 per share will be limited to 149 prospective investors. BioPharmcor B.V. has currently approximately 27 million common A shares outstanding at this time.
According to Dawid Mrotek, BioPharmcor's Director of Investor Relations, "BioPharmcor has a very exciting and focussed development program in place to develop a pipeline of generic drug products to improve Men's health. We have successfully funded our development program to date through a corporate bond program which we will continue to offer through our Poland based unit BioPharmcor Sp. z o.o." Adds Mr Mrotek, "We have taken note of the fact that there is a large contingency of investors who have an interest in investing in the shares of BioPharmcor B.V., the group's parent company. We anticipate that should we receive a strong demand for BioPharmcor shares in this initial round of the Company's private placement, we may well expand this funding strategy in conjunction with our debt offerings to address future requirements."
The BioPharmor Group is currently developing a generic tadalafil drug product which is recognized as a first line treatment for Erectile Dysfunction (ED) and Benign Prostatic Hyperplasia (BPH). Proceeds from the Company's private placement offering will be used for further development work.
Established in 2014, Amsterdam based BioPharmcor B.V., has two operating subsidiaries, BioPharmcor Sp. z o.o. in Warsaw, Poland and BioPharmcor Inc, in Ottawa, Canada.
VMS Rehab Systems Inc. was established as a Canadian incorporated company in 1998. In addition to controlling BioPharmcor B.V., VMS Rehab Systems Inc. has been active in the home health market in North America for the past 18 years. More recently, the Company has been evaluating additional market opportunities to grow its business into a fully integrated Health Industry company.
VMS Rehab Systems Inc. operates through its offices in Ottawa, Canada and affiliated BioPharmcor offices in Amsterdam, The Netherlands and Warsaw, Poland.
The shares of VMS Rehab Systems Inc. are quoted on the OTC Market 'pink current' symbol: VRSYF.
FORWARD-LOOKING INFORMATION: Certain statements contained in this press release constitute forward-looking information. These statements relate to future events or future performance. The use of any of the words "will" and similar expressions and statements relating to matters that are not historical facts are intended to identify forward-looking information and are based on the Corporation's current belief or assumptions as to the outcome and timing of such future events. Actual future results may differ materially. Various assumptions or factors are typically applied in drawing conclusions or making the forecasts or projections set out in forward-looking information. Those assumptions and factors are based on information currently available to the Corporation. The forward-looking information contained in this release is made as of the date hereof and the Corporation is not obligated to update or revise any forward-looking information, whether as a result of new information, future events or otherwise, except as required by applicable securities laws. Because of the risks, uncertainties and assumptions contained herein, investors should not place undue reliance on forward-looking information. The foregoing statements expressly qualify any forward-looking information contained here.
To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/vms-rehab-systems-incs-generic-drug-unit-launches-first-private-placement-of-class-a-shares-300281596.html
SOURCE VMS Rehab Systems Inc.


text:
This charming garden restaurant & bar in Rome offers welcome respite from the Roman summer heat, surrounded as it is by ancient stone walls, flowers and ivy. A luxurious retreat set in the heart of the hotel and borders the Borghese gardens and decorated with charming wrought-iron furniture.
The Palm Court offers a wide choice of food all day long: coffee with home-made cornetti, light salad lunches, ice creams, a selection of ice teas and "sgroppini", cocktails (ranging from the more traditional to the more imaginative created by our bartenders), romantic dinners, and late-night drinks - accompanied by live piano music from 7:00 pm on.The cuisine is guided by the Chef Francesco Apreda who, with his trustworthy sous-chef Marcello Romano, offers dishes dedicated to genuine Italian and traditional Roman flavors.A contemporary-designed American bar fills the Palm Court with a play of light and water, bringing a touch of playful contrast into the refined and elegant atmosphere of this precious garden in the heart of Rome.
Hours: 7:00 a.m. – until late. April - OctoberReservations: email email@example.com or tel. +39 06 699340
Palm Court Garden Restaurant Menu


text:
15%Off sale
15% Off Sitewide
Join the email list and you'll get 15% off your next order.Get Offer
These BCBGeneration promo codes have expired but may still work.
Our team is confident that we have found the newest BCBGeneration coupons. Feel free to check similar sites and share with us if we missed something.


text:
Kill or Be Killed Trailer (1976)
"Not just a challenge...the only way to survive!" 17 June 1976 Adventure, Action 90 mins
Two former ranking figures of the Axis powers (the evil General Von Rudloff and Japanese master Miyagi) schedule a deadly martial arts tournament in Von Rudloff's desert castle. They race to assemble the top competitors from around the world, with the rebellious Steve Hunt being the most sought after.
Watch the official Kill or Be Killed 1976 trailer in HD below or find more Kill or Be Killed videos on Vidimovie.


text:
Sarapopovic.com offers full service, tending to clients needs. For your preferences we can hire fashion and hair stylist, make up artist and also prop and set editor.
Sarapopovic.com offers complete schedule of work process, along with delivering images before the due date
All of the images produced are retouched based on your needs in Photoshop CC.
A strong work ethic is vital to a achieving our goal.


text:
CodePlexProject Hosting for Open Source Software
Could someone advise if how tight is the integration of Test Manager and workitems using this template? I'm wondering about TestCase Work Item Type of the Agile Template.
Hi Mescom321,
The Kanban process template is based on the MSF Agile template. We just added two new Work Item Types (Process Step and Card), the reports (Kanban Board Report, Cumulative Flow Diagram) and . We intentionally didn't modify any of the existing WITs (such
as Test Case, Shared Step, User Story or Task) so that we didn't effect any of the existing Test Manager features.
The idea was that we would "extend" and existing template rather than "modify" the template and have to update all of the reports and dependant tools.
Are you sure you want to delete this post? You will not be able to recover it later.
Are you sure you want to delete this thread? You will not be able to recover it later.


text:
You're in :
/ online-store
/ clothing
/ Rokker Denim
/ all-collections
/ Mens
/ Red Selvage Raw Jeans
The Original Rokker jeans are a high quality motorcycle jean from the Swiss manufacturer. Made from high quality denim and Scholler Dynatec material, the Rokker Red Selvage jeans are a comfort fit jean.
* Classic comfort fit (straight cut) with button fly
* Outer material made of finest 13oz Raw Selvage denim (100% cotton)
* Inner material made of 100% schoeller®-dynatec (non abrasive, wind resistant, water repellent)
* Without rivets which could scratch the bike
* Easy care (washable at 40°, ironing after wash increases the water repellency)
* Delivered in a wooden box with T-shirt


text:
A Very Warm Welcome to Schlosshotel Münchhausen!
Schlosshotel Münchhausen, a 5 star superior hotel with 68 luxury rooms and suites, two restaurants, one with a Michelin star, and 12 function rooms, located in the Natural Park Weser Highlands Schaumburg-Hameln welcomes you.
Set in idyllic parkland, lovingly restored and modernized in 2004 the castle from the 16th century combines the conveniences of luxurious living with a rich history.
The spacious spa area, the two adjacent 18-hole golf courses, the natural surrounding and the proximity to the historic city Hamelin offer endless options.
We are looking forward to greeting you at our beautiful castle!
Our Highlights:
"Apartment Kleine Mühle"
from the 7th night
100 Euro per night
"Gourmet Deluxe"
2 nights, dinner at the Gourmet-Restaurant and in the Schlosskeller from 740 Euro per double room
"Sunday Night Special"
One night and 3-course menu from 225 euros per double room


text:
Free Shipping Over $75* Holiday Sale Event >COUPON CODE: BFCM17
• Only available as a set of 2• Upholstered in taupe leatherette• Polished stainless steel base• Elastic webbing seat
The Basilio Taupe Dining Chair has a distinct serrated form created by its zigzag steel frame and cantilever seat construction. This energetic, contemporary dining chair is upholstered in leatherette and has a polished stainless steel base. It also features an elastic webbing seat to keep you and your dinner guests comfortable. Only available in sets of 2.
Learn more about dining seating with our buying guide.
Price: $556.00
Price: $579.00
Price: $612.00
Price: $60.00
Price: $189.00
Price: $109.00
Price: $229.00
Price: $99.00
Price: $298.00
Price: $159.00
Price: $608.00
Price: $436.00
Price: $337.00


text:
STAFFORD TOWNSHIP — It's been about 30 years since the township held partisan elections and next month a large number of candidates will face off, but most of them are running as independents.
Two years ago, the public voted to changed the election process to partisan and move the election from May to November.
Six Township Council seats and the mayor's post are up for election.
Six independent candidates and six Republican candidates are vying for the council seats.
Meanwhile, 24-year incumbent Republican Mayor John Spodofora is challenged by two independent candidates. Spodofora has served on the council since 1988, but earlier this year it was unclear whether he was going to run following an attack by former township Republican Club President Martha Kremer on his Vietnam war record. But in March, the club endorsed the 66-year-old Spodofora as the mayoral candidate.
The seven Republicans running in the township, including Spodofora, are split into two slates — Moving Stafford Ahead and another slate that is unnamed but made up of incumbent Councilman Henry Mancini, Paul Krier and Lori Wyrsch.
Seven independent candidates, including Paul Marchal, who is running for mayor, are part of the We Are Stafford ticket. Marchal, a six-year resident of the Beach Haven West section of the township, owns Edible Arrangements in the township and sits on the township Zoning and Planning boards.
The second independent candidate running for mayor is Thomas Litwin, running alone on the ticket "Litwin Rocks Manahawkin." Litwin was arrested in August by township police after undercover narcotics allegedly made purchases at his Beach Haven West home. Litwin, 43, was charged with distribution of marijuana to an undercover police officer, possession of marijuana over 50 grams, possession of synthetic cannabinoids and possession of CDS paraphernalia.
There are no Democrats running.
See candidates list below
Contact Donna Weaver:
Follow Donna Weaver on Twitter @DonnaKWeaver
Stafford Township mayor and council candidates
Moving Stafford Ahead slate
John Spodofora, mayoral candidate
Mayor since April 2011, Township Councilman 1988-2011
Stafford resident since 1957.
Married to Helen, father of two children, three grandchildren, all Stafford Township residents
Chairman of the Stafford Township Environmental Commission 1986-2011
Active duty U.S. Navy 1966-1973, honorable discharge.
Retired 2012 site manager of cost analysis & estimating division, U.S. Naval Engineering Center Lakehurst
2008 Department of the Navy Meritorious Civilian Service Medal
Spodofora says he is running on his record of what he has done for the township in the last 24 years and not making promises about what he's going to do.
Stephen Fessler
Councilman since 2009, current council president
Stafford Township resident since 1979
Married to SallyAnn, a registered nurse at Southern Ocean Medical Center. Father of three, seven grand-children
Building-supplies salesman
Serves on the township Planning Board
Running for office to continue to expand shared services, expand the township's community outreach program, continue to reduce the size of government and improve the quality of life for residents.
Robert Kusznikow
Councilman since 2009
Stafford Township resident since 1977
Married to Susan, father of three children, four grandchildren
Served in the U.S. Marine Corps 1966-1971, with Vietnam service
Currently a business owner of Dollar Discount Stores, Casino and Fishing Charters, Auto Repair Weld Shop and Retro Fitness in Stafford Township
Running for office to continue providing cost savings to taxpayers through serving on the board of shared services, where he says he worked to develop shared services agreements with surrounding municipalities.
Sharon McKenna
Stafford Township resident since 1998
Married to Michael, mother of three sons
Works as the education and special events coordinator for Viking Village in Barnegat Light, educating the public on responsible fishing methods by commercial fishermen. She also works to assist creating legislation to govern the nation's fisheries.
Tuckerton Seaport Board of Trustees since 2007
Member of the Stafford Township Planning Board 2002-2011
Bachelor of arts, Stockton College, Villanova master's certificate in advance project management
McKenna said she has served the town in many capacities since the moment she moved here 14 years ago. She said she is running for council because she wants her children to be able to afford to live in the township and be able to raise their family here.
Additional Republican candidates
Henry J. Mancini
Incumbent councilman since May 2011
12-year resident of the Cedar Run section of Stafford Township
Married to Mari, father of three children
Owner, Henry J. Mancini & Associates Inc., a real estate valuation and consulting firm in the Mayetta section of Stafford Township
Commissioner of the Ocean County Library System since 2007, and currently serving as the board chairman for the third consecutive year.
Board member of the Ocean County Health Department since 2010
Mancini said he is looking to bring open and accessible government to the residents in Stafford Township and is also looking to give back to the community and provide fiscal responsibility.
Paul Krier
15-year resident of Stafford Township
Married to Kate, father of two daughters
Serves on the Stafford Township Environmental Commission
Supervisor of facilities maintenance and technical assistance, New Jersey Water Supply Authority, Manasquan Water Supply System
Krier said he is running because he feels there has been too much drama in the local government. Krier also said he is looking to work on fiscal responsibility in the township and maintain the reasons why he moved here, such as low taxes and good, local recreation programs.
Lori Wyrsch
20-year Stafford Township resident
Married to Jeff, stay-at-home mother of four boys
Graduated from Southern Regional High School, Monmouth University
Former Stafford Township School District's public relations/community liaison officer, 1999-2003
Served on the Stafford Township Board of Education 2008-11
Wyrsch said she decided to run for council after serving on the township Board of Education for three years. She wanted to step up to help the township more and give back to the community that has given so much to her and her family.
We Are Stafford slate
Paul Marchal, mayoral candidate
Resident for six years of the Beach Haven West section of the township
Married to Stephanie, father of two children
Owner of Edible Arrangements in Stafford Township
Member of Stafford Township Planning and Zoning boards
Worked as an accounts receivables manager and operations manager for Sharp Electronics, Liz Claiborne, Halston Borghese, Calvin Klein and Jordache.
Marchal says he is very confident he can make some very positive changes in the township by calling on his leadership experience and financial corporate background.
Joanne Sitek
Incumbent councilwoman since 2009
15-year resident of the Beach Haven West section of the township
Bachelor's degree in education, master's degree in behavior services/study
Retired teacher and counselor of 38 years
On the We Are Stafford campaign website, Sitek says she believes that Stafford Township needs a mayor and council that works for the citizens and their concerns.
David J. Taylor
Stafford Township resident for more than 20 years
Married to Lynn, father of two children
Graduate of Southern Regional High School
President of TaylorMade Cabinets in Stafford Township
President of the Bay Avenue Business Association and is a member of the township Zoning Board
Taylor says on the campaign website that his "approach is one of good common sense, good business sense and anyone who knows Dave will tell you, if you don't want an honest answer, don't ask him."
Esther M. Libenschek
Township resident for eight years
Married to Eric and mother of one daughter
Sales and service specialist for Bank of America in Stafford Township; owns and operates Allstar Building Systems and American Office Cleaning with husband, Eric
CCD teacher at St Mary's, Stafford Township, for five years and adoration adorer at St Mary's, Barnegat Township for four years
On the campaign website, Libenschek said she decided to run for office with a team that has a platform of fiscal responsibility after working in a bank and seeing the tough financial decisions senior citizens must make.
Ben H. Pieper
Stafford Township resident since 1994
Worked as a carpenter in Ocean County for 33 years; for the last 16 years worked as a carpenter at Great Adventure Six Flags Amusement Park
Pieper says on his campaign website that his "only concern is ensuring Stafford residents are fairly represented. He believes the people of Stafford should be the sole decision makers of their own town and its future, no one else."
Christopher J. McManus
Township resident since 2001
2010 Southern Regional High School graduate
A business student in the Stockton College Honors Program; 2012 graduate of Ocean County College
McManus said he is running for office to work to bring more activities and options for younger residents in the community.
Brian White
Township resident since 2002
Married to Renee, father of four children
Received a bachelor's degree from the University of Scranton and law degree from Widener University School of Law
Sole practitioner at the law offices of Brian Corley White in Toms River and active member of the Ocean County Bar Association
On the campaign website, White says that as a small-business owner, he is interested in helping grow the local business economy in Stafford Township.
Litwin Rocks Manahawkin slate
Thomas J. Litwin, mayoral candidate
Litwin has no website and could not be reached for comment.


text:
ESMA has published updated AIFMD Q&A with new reporting issues and some additional guidance on marketing.
The new Q&As are located in the following sections of the paper:
- Section III: Reporting to national competent authorities under Articles 3, 24 and 42.
- Section IV: Notification of AIFMs.
- Section VII: Calculation of leverage.
- Section X: Additional own funds.
- Section X1: Scope.


text:
- select colour
it's an internet thing!
it's an internet thing!
10:28 24 February 2010
Strictly star Jason Wood has passed away aged 38.
The funnyman, who was a contestant in the first series of Strictly Come Dancing, died in his sleep on Saturday.
He became the first contestant to be voted off the dancing show,when it made its debut back in 2004.
Wood was best known for his comical musical impersonations, ranging from Cher to Morrisey.
He also became a regular performer at the Edinburgh Festival and frequently headlined at comedy clubs.
Chamber Management, who represented the funnyman, said there were no suspicious circumstances surrounding his death and that any further details were pending the autopsy results.
"We are devastated by the loss of our client Jason Wood," said Hannah Chambers and Sophie Church in a joint statement.
"He was an inspiring & individual performer who believed that 'variety' was the spice of life and whose wind ups were legendary.
"He was also a warm-hearted and caring man. We have lost a friend as well as a client and he will be truly missed."
Disclaimer: Supanet is not responsible for, and disclaims any and all liability for the content of comments written by contributors to this website


text:
Role: Abhimanyu
Role: Contestant
Role: Karan
Kanchan's 23 year old brother, Karan is a born charmer. He charms everyone with his never ending tales, his forgetfulness, his outgoing nature and his endearing smile. His helpful nature lands him in trouble more often than not but that's just one more reason why everyone loves him. No one can help but get attracted to him and Suman is no exception!
Role: Ex - Prem
He is the love intrest of Simar
Film Stars on small screen are wonder to see. Find out the list of Shoaib Ibrahim Shows and know him more as a Television Star in Shoaib Ibrahim TV Shows section. Did you like the show? Just leave a comment!!!
Disclaimer: All Logos and Pictures of various Channels, Shows, Artistes, Media Houses, Companies, Brands etc. belong to their respective owners, and are used to merely visually identify the Channels, Shows, Companies, Brands, etc. to the viewer. Incase of any issue please contact the webmaster.
Popular Channels :
Quick Links :


text: im kinda new to this thing htc android, so i downloaded this handcent sms, i loved it BUT...i kept receiving txt msgs from one of my contacts, looks like its some spam msgs. i talked to her regarding her never ending messages, and she never sent me any of those messages. its weird because she never texted me or anything, but i kept receiving text msgs from her phone number and the msgs are always about HTC. every start of each txt msgs i get from her is HTC: ___ etc. its like htc and i are chatting.. I keep getting them, sometimes one after the other, non stop. sometimes every five minutes, sometimes worst, i get one and then the next. then it stops minutes later i get 5 msgs. its from her name and number, but the first word is HTC. ITS LIKE IM CHATTING WITH HTC. its giving me some links, talkin bout htc etc. is there any way i can stop this? its very annoying=(


text:
The Gruffalo and Other Stories DVD
The Gruffalo
- In Stock
- Product code
- Format
- DVD Box Set
All your favourite Gruffalo and other stories in one beautiful 3 disc DVD collection.
The Gruffalo:
The Gruffalo tells the story of a mouse who is forced to rely on his wits for survival when confronted by three hungry animals. To scare them away he invents an imaginary monster with terrible teeth and terrible claws. But what happens when Mouse comes face to face with his own creation.
The Gruffalo's Child:
The Gruffalo's Child, is the tale of the brave little Gruffalo who ignores her father s warnings and tiptoes out into the snow in search of the Big Bad Mouse. On the way she meets Snake, Owl and Fox but no sign of the fabled Mouse. He doesn't really exist... or does he?
Room on the Broom:
Room on the Broom is a magical tale of friendship and family about a kind witch who invites a surprising collection of animals to join her on her broom. When the gang saves the witch from a fearsome dragon she rewards them with a magnificent new broom which has room for everyone.


text:
short & sweet ♡
mystic messengermysmeyoosungyoosung kimshiba inulittle puppy yoosung! (´ ▽ `) ♡I want one to bring home~I feel like I don't draw enough of yoosung even though I think he's such a little sweetheartI hope everyone's coping with the outcome of the V route ;_;I'm currently in a very stress period of my lifethank you to all the new followers! also my old followers y'all are awesome!I really appreciate that you all support my art so muchsometimes I get overwhelmed by all the others who are better than meit can seem very intimidating sometimesbut always remember that you are awesome in your own way!I hope this little comic can bring you a fuzzy feeling inside!long tags ;u;


text:
The God of Time (Jason Dohring) sends Dean back to 1944, where he is arrested by legendary lawman Eliot Ness (Nicholas Lea)
Supernatural Season 7 Episode 11 "Adventures in Babysitting"
Sam helps a teen girl search for her missing father, who is also a supernatural hunter. Meanwhile, Dean tries to take down Dick Roman (James Patrick Stuart).
Supernatural Season 7 Episode 7 "The Mentalists"
Sam and Dean investigate when an angry spirit murders mediums in the so-called most psychic town in America. But the two have trouble locating the medium who is controlling the homicidal ghost.
Supernatural Season 7 Episode 6 "Slash Fiction"
Sam and Dean are cloned by two Leviathans who go on a killing spree as the two brothers, which lands the real Sam and Dean on the FBI's most wanted list. Meanwhile, Bobby tries to find a way to kill the Leviathans.
Supernatural Season 7 Episode 5 "Shut Up, Dr. Phil"
A jealous witch (Charisma Carpenter) unleashes her wrath on a small town when she discovers her husband (James Marsters) is having an affair.
Supernatural Season 7 Episode 3 "The Girl Next Door"
Sam hunts a demon from his childhood who is killing thugs and eating their brains.
Supernatural Season 7 Episode 2 "Hello Cruel World"
Sam experiences hallucinations caused by the broken wall in his head. Meanwhile, Castiel struggles with his newfound power; and Bobby worries about Dean as he tries to fight Castiel and take care of Sam.
Supernatural Season 7 Episode 1 "Meet the New Boss"
Castiel doesn't kill Sam, Dean and Bobby but warns them not to interfere in his business. Assuming his new role as God, Castiel sets out to right some of the wrongs in the world.


text:
We are Stonewood Design. We are an award-winning architectural practice, based in Castle Combe, just outside of Bath.
We are honoured to have received a RIBA National Award, for our project Myrtle Cottage Garden Studio. This award celebrates architecture of the very highest level. The project demonstrates a sensitive approach to a beautiful landscape setting.
Most recently, we were named the BD Small Project Architect of the Year 2016.
As a practice we can be nimble, light-footed and fresh in reacting to your needs and the requirements of your project.
We always enjoy a close working relationship with our clients, developing ideas iteratively to ensure that we realise the full potential and maximise the opportunities of the particular project.
We work by listening.
We pride ourselves in being able to develop a vision for your project which reflects your requirements, whilst ensuring that we all enjoy the process along the way.
We have diverse expertise and workload. Current projects include a museum, a prep school and nursery, a sustainable housing community, a low energy workplace, private houses and healthcare work.
We have a track record of successful planning permissions and listed building consents, be it a contemporary new home or breathing life into a historic farm building.
Our work is founded in building. We enjoy how things are put together and care passionately about the detail; a beautiful timber stair, or the sparkle of sunlight from a well placed window.
We are able to offer you the benefit and expertise of working closely with Stonewood Builders, our sister company. We can provide you with a fully integrated "turnkey" service from the inception of your project through to completion. Equally, we can provide a traditional architectural service, wholly independent from Stonewood Builders.
Stonewood Design is led by Nicola du Pisanie, Matt Vaudin and Adam Chambers.
Architect's Journal 14th February 2013: New Practices
Building Design 21st February 2014: First Look: Pod Gallery
At Home May 2015: Myrtle Cottage Garden Studio "All part of the scenery"
Dezeen: 18th June 2015: Pod Gallery http://www.dezeen.com/2015/06/18/private-pod-gallery-stonewood-design-cantilevers-inside-stone-walls-17th-century-barn-west-littleton-village-cotswolds-england/
Dezeen: 19th June 2015: Myrtle Cottage Garden Studio http://www.dezeen.com/2015/06/19/stonewood-design-weathered-copper-pavilion-wildlife-hide-english-cottage-myrtle-garden-studio/
Architect's Journal 19th June 2015: Myrtle Cottage Garden Studio "37 RIBA Awards"
RIBA Journal September 2015: "Rustic Pleasures"
BBC2 3rd February 2016: The £100K House