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Joris and Boris Trailer (2012)
17 July 2012
When Joris (Martijn Nellestijn) and Boris (Richard de Ruijter) of a notary is an important but mysterious heirloom in hands, the duo goes in search of the precious possessions of their ancestors. While Inspector Jankers (Frederick the Great) thinks that the duo wants something naughty tricks, he follows them to the island of Cyprus. If George and Boris friends with Max, Michael and Anna end up in the hotel Aunt (Inge Ipenburg) and her sidekick Grudo (Bartho Braat). These two, however suspiciously interested in the quest of the group of friends ...
Watch the official Joris and Boris 2012 trailer in HD below or find more Joris and Boris videos on Vidimovie.

subset: commoncrawl


text:
Process Scale Liquid Chromatography
Category: E-Book
Process Scale Liquid Chromatography by Ganapathy Subramanian
English | 18 Jan. 1995 | ISBN: 3527286721 | 241 Pages | PDF | 13 MB
This book provides the industrial chromatographer and production scientist with a comprehensive account of process scale liquid chromatography.
The basic theory is presented, guiding the reader through system design, simulation and modelling techniques, giving due consideration to economic aspects, as well as safety and regulatory factors.
Mirror Links


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How do I find a book review?
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text: So I decided that I had no reason to not upgrade to the OTA 2.2 since I was running Tranquility with a modified Revolution theme. I could do everything I was currently doing with the OTA and the newer radio. I have been having issues with my DX dropping my calls in the the same places I always did with AT&T on my drive home. I hope the radio is better because coverage was one reason I came back to Verizon. I also like being able to keep track of what I am doing now as well. I kind of went nuts when I got my DX and installed a lot of crap and would like to do it better this time. Hopefully this will help someone else go through the process if they choose to. I see a lot of "New DX, what should I do first" posts, but don't see "What should I not do?". - I used the SBF to get back to 2.1 (A lot easier when I found out that the reason the RSDLite "Start" button was disabled. I had to shorten the filename and put it directly on C:\ - at least doing those 2 things made it work. It failed the first time, but the second was fine. - After SBF, phone would not boot until I wiped data and cache. - Updated to OTA - Rooted using the Droid2 method (only took 10 minutes - a lot faster than the first time which took me 2 hours) - Installed my new 32GB card and documented what was there from the system - Installed ROM Manager, flashed the recovery, & backed up ROM which added the "clockworkmod" directory and an update.zip on the SD card root - Now install your favorite apps, ROM, and/or theme. So, on to what I will not do this time. - This time I will not backup apps through the market. It sucks when you reset or install a new ROM. Use Titanium Backup or similar. - Don't install every app that looks interesting or amusing and be prepared to delete the data after you uninstall an app you don't want again. I know what apps I like and need this time so hopefully I will not have 20 directories on my SD with nothing in them and random files on the card root. - Take backups before and after every major (and some minor) changes (and name them something you will understand). You can always back the backups up to your computer. (I have a script that runs automatically when I connect my phone.Plus I have room for more music and movies now. What are some things you would do different if you could start over - on your phone - not your life?


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|12 Nov 2012
Apparently it has something to do with Acronis True Image:
After some searching, this is what I've done:
1. Logged out of the Sync in Acronis ([DUPLICATE] Slow folder display issues possibly caused by Acronis True Image 2013? | Knowledge Base) [I already had "Acronis Nonstop Backup Service" and "Acronis Sync Agent Service" stopped and set to manual, and so I started "Acronis Sync Agent Service", logged out of Sync and stopped the service. Left "Acronis Scheduler2 Service" on and set to Automatic]
2. Renamed ti_manager_proxy_1.dll (Com Surrogate failure | Knowledge Base)
Now I have dllhost.exe running but the problem doesn't happen. Hopes it stays this way.
If not, apparently it only happens with Acronis 2013, so I'll install the 2012 or 2011 version.
Edit: this solved it.
|My System Specs
|13 Jan 2013
Windows 7 Home Premium x64
Guy1, you are my absolute hero.
I've struggled with this problem for a month now. First it was just plain annoyance, lately it has become impossible to do my work, let alone the bad impression I gave my customers when I fixed their PC's but couldn't fix my own.
I've tried everything, and also followed your instructions, and failed. I was at the end of my wits...and only then I discovered that there was a second page. The second I saw the word Acronis, I knew what triggered the problems. Removed it, no problems ever since. You are awesome. So awesome I made an account on this forum only to mention your awesomeness :-P
Thanks a bunch and keep up the good work.
|My System Specs
|13 Jan 2013
Guy1, you are my absolute hero.
I've struggled with this problem for a month now. First it was just plain annoyance, lately it has become impossible to do my work, let alone the bad impression I gave my customers when I fixed their PC's but couldn't fix my own.
I've tried everything, and also followed your instructions, and failed. I was at the end of my wits...and only then I discovered that there was a second page. The second I saw the word Acronis, I knew what triggered the problems. Removed it, no problems ever since. You are awesome. So awesome I made an account on this forum only to mention your awesomeness :-P
Thanks a bunch and keep up the good work.
|My System Specs
|15 Feb 2013
Windows 7 64-bit
I have been having this problem for several months, and tried everything on this site and others to no avail. I even dealt with the Acronis 2013 dilemma, and it did not solve it.
What did finally work was going into My Computer > Advanced System Setting > Advanced > Performance Options > Visual Effects. I turned off Aero Peak, and several others, and it solved my issue. I also turned off all the "Fade" options and few others as well. Now my system is stable and windows explorer opens without incidence.
My suggestion is look at your graphic intensive processes and go from there. You may have to play around with some of the visual effects to get the problem resolved... Worked like a champ and has not reoccurred in over a month.
|My System Specs
|13 Jun 2013
Windows 7 Home Premium 64 bit
WOW....Guy1 you saved the day...
I did all looked into possibilities for this blank My Computer until I zeroed on dllhost*.exe which is associated with Acronis True Image 2013. To identify this blank outs I ran sfc, malware, anti-virus scans, uninstalled couple more programs, but I didn't find this root cause. I even don't know how to key in tag word to google out this program. But google image searched help when I uploaded my screen shot which matched your...& whole problem solved. My one techie friend advises to format & re install but I was not at all ready for it as I found out its system application interfering this. In past when I use to encounter this problem I use to log off by keeping task manager on & then I use to click Cancle as Windows wait to background programs to end, so after clicking Cancle My Computer started to work fine but still I didn't founded the culprit dllhost....!!!
So big thanks to Guy1...you really saved the day...& Most important this platform from where I got DIY attitude...BIG THANKS-SevenForums....
|My System Specs
|04 Dec 2013
windows 7 32 bit
thanks a million bro you are truly my hero .you saved me
|My System Specs
|08 Mar 2014
windows 7 home premium x64
hey bro..
m also having same problem..when i try to access DOWNLOAD FOLDER (specially) .... icons go blank n my computer folder does not show..
same as u attached the screenshot..
plz help me...
|My System Specs
|02 Sep 2014
Hey, people. I checked out this thread, and I have the same problem. However, dllhost.exe is not a problem for me (it seems), as it doesn't show in Task Management.
I also tried the visual settings which someone talked about, and it helped partially. Now I can see almost all the desktop icons, however not all of them, and my computer is still very slow.
I'm running a full virus scan in order to make sure I'm not infected.
Can anyone help this noob?
|My System Specs
|02 Sep 2014
Windows 7 Pro 32
It only shows if you first click the button Show processes from all users. Icons and thumbnail problems are related to dllhost. I suggest you take a look here: Windows 7 dllhost.exe memory leak - Microsoft Community
|My System Specs
|02 Sep 2014
I tried clicking the button Show processes form all users, but it only shows for a couple of secons and then it disappears again.
Also, I tried some of the answers you linked to. Downloading Media Preview did not solve the issue (it actually made all the icons turn white again). Neither did the Autoruns, however I'm not sure how to apply these changes. I tried saving them, but I only get a file which I don't know where to put. Also I tried resetting the thumbnail cache using the Run command "cleanmgr", but nothing happens when I press Enter.
I also have trouble opening some programs.
|My System Specs
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text:
Troops of Indian and Oman armies were today given security briefing ahead of their second joint exercise "Al Nagah-II 2017" in Bakloh belt of Himachal Pradesh.
"Initial orientation and security briefing were carried out. Itsds also included the training aspects and area familiarisation," PRO Defence, Jammu, Lt Col Manish Mehta said.
The 14-day joint exercise will begin tomorrow in the Dhauladhar Ranges at Bakloh.
"This is the second joint military exercise between the two countries which have a history of extensive cooperation in defence arena. The first one was held in Oman in January 2015," he said.The PRO said the participating troops for this exercise have been drawn from one infantry battalion each from the Indian Army and the Royal Army of Oman. Read More…


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|09 May 2011
IE 9 Compatibility Issues with Certain Frameworks
First off, I like IE9 for most anything. I only wish it were more compatible with some of web sites I frequent.
One of my hobbies is taking consumer surveys. I subscribe to a number of survey sites and get invitations every day. I found that when I upgraded to IE9 from IE8, I could no longer take certain surveys because the framework they were built with did some things that IE9 wouldn't deal with as IE8 did so well. I'm sure these web site building frameworks are doing all sorts of undocumented and down right evil things.
Speaking of evil frameworks for web sites - my oldest daughter teaches on-line classes in IT at a university in the northwest. She discovered that the commercial web site builder they were using did some bad and silly things with IE9. She had to tell all her students they had to avoid IE9 if they were in her class. When she visited a few weeks ago, she demonstrated some of these gems for me. Nothing crashed, but certain things just didn't work or look right.
What does work for me now is Chrome. I use it to access the gmail account I use for the survey invitations and then to run the surveys. Chrome never fails to do the right thing. I have also used virtual XP mode and IE8 with the expected success. It's just easier to launch Chrome and do my surveys. I use IE9 for all other web browsing.
To be sure - the IE9 compatibility mode does not solve these issues.
|My System Specs
|09 May 2011
Windows 8.1 ; Windows 7 x86 (Dec2008-Jan2013)
Crunchy Doodle, can you please give more specific information, examples etc?
|My System Specs
|09 May 2011
That's a fair question asking about examples . . .
The worst is one web site that insisted I did not have Flash 10 installed and refused to allow me to continue. I obviously have the most recent 10.2 that works so well with the nVidia GPU I have. I've also had links that just time out for no apparent reason, and when I go into Chrome and follow the same links, they work fine. My daughter showed me where the full screen editor she and her students use within the school's web site. She could not use the yellow highlighter tool, and had quite poor control over color in general. Her students are required to be able to fully utilize this on-line editor, which only works right in IE8 or some other "older" browsers. We tried IE9 with compatibility and that did not clear up all the color issues.
I also try accessing these survey web sites with my Android tablet. Using Dolphin HD I get compatibility somewhere between IE8 and IE9. That same web site that said I didn't have Flash didn't like Android with Flash 10.2 either. These web sites are using somewhat crappy infrastructures to do their presentations. We have to adapt if we want to use the web site they're built with.
|My System Specs
|09 May 2011
Windows 10 Pro (x64)
The websites have to be compatible with IE 9, not the other way around. The problem is most likely these sites are doing something specific for IE that does not work in the latest version. IE 9 is a lot more standards complaint then previous versions, a lot of the bugs that some of these frameworks are using no longer function.
|My System Specs
|10 May 2011
Yes, that is the case. Now convince the operators of these web sites to clean up their act - not going to happen any time soon. So it does not matter how wonderful IE9 is if it does not work with the web sites that are out there in the world, no matter how wrong they are.
The websites have to be compatible with IE 9, not the other way around. The problem is most likely these sites are doing something specific for IE that does not work in the latest version. IE 9 is a lot more standards complaint then previous versions, a lot of the bugs that some of these frameworks are using no longer function.
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text:
The somewhat good news is that Nokia today reported that it sold 4 Million Lumia phones in 3 months, though these are low numbers considering what Nokia was used to in the past, but it is good news because it shows mobile users aren't afraid of change. The Windows Phone OS platform is fairly new to the mobile ecosystem and many predicted it would be tough to penetrate into a market already dominated by Android and iPhone, but these numbers indicate that Nokia "exceeded expectations".
The dismal news however is that the Lumia phones (particularily the flagship Lumia 900) sold only 330,000 units in the US, and considering the amount of money Nokia, At&t and Microsoft put into marketing the device, and not to forget the gifting of $100 to every Lumia 900 buyer on the At&t network, Nokia put alot into this device and 330,000 units is really REALLY poor!
The news of Nokia's 2nd Quarter was well received as their stock rose 13%, indicating that investors were impressed with how the devices were doing.
Nokia did record a $1 Billion operating loss in that quarter also. YIKES!!
Since the introduction of Lumia devices (last year November), Nokia has sold over 7 million units, while Android and iPhone sell 3 times that amount in a single quarter.
The emergence of Nokia WP8 phones should gradually shift the tide back Nokia's way, with Nokia promising new captivating devices no one has seen before.
Expect these devices to be unveiled in September when Nokia hosts Nokia World!
You can check out Nokia's full Quarter report HERE


text:
Traveling from New Orleans to Chicago June 6 to 9. I have waited up till midnight the past 2 nights, logged onto opentable at midnight, and all that was available both nights was a 900 Goosefoot. Grace totally booked at 1201 am! I booked the 9 pm but ideally we would prefer an earlier reservation since I assume its a long meal. The machine at Schwa is always full.
So, are their any tricks for a foodie out of towner to get into these restaurants?
If we can't get into these three, what's the next alternative? I've got Tru booked already. Any other new up and coming restaurants? We did Alinea several years ago and don't need to go back. Great meal but would prefer to try something new. Thanks for any help!!!


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Veteran Member
Date Joined Mar 2006
Total Posts : 1451
Posted 6/17/2006 2:10 PM (GMT -7)
OK, after almost 2 months of no problems I have been hit again with the cramping, nausea now for a couple days. Thanks for all the congratulations before when I thought it was gone and not IBS at all. So much for bragging! LOL. I am convinced that this is stress related more now than ever. The last week I have been under tremendous stress due to a couple things and feel that is why this has all started again. Now most of that is resolved but I hope it doesnt take me months again to get back to normal whatever that is. Not really posting for any other reason except to mention that I think this IBS or whatever is more stress related then I thought. Pepto Bismol, heating pad here I come. There was no food reason to bring this on so what else can it be.
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Veteran Member
Date Joined Apr 2005
Total Posts : 3269
Posted 6/17/2006 11:02 PM (GMT -7)
So sorry to hear about
your recent relapse. It's always like that, isn't it? As soon as you acknowledge that you're better, BAM!, you're not anymore.
I totally agree with you that it could be mainly stress related. While I was on vacation I ate fried foods and dessert everyday. Not once did I have a problem. Back home if I do that I would be running for the toilet and doubled over in pain. Stress!! Everyday life really takes its toll.
Anyway, I hope you get back to feeling better soon. Maybe try taking some probiotics and doing relaxing exercises.
Take care.
Co-Moderator for the IBS Forum
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Regular Member
Date Joined Dec 2005
Total Posts : 251
Posted 6/18/2006 3:10 AM (GMT -7)
Cannyonbabe.. So sorry to hear that!!!! I do think stress has something to do with it.. I am going thru selling our house and moving... That is very stressfull... But I still think it is something else to besides stress inside our bodies... Hope you feel better...
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Regular Member
Date Joined Jun 2006
Total Posts : 38
Posted 6/18/2006 5:02 AM (GMT -7)
Hey guys... i sooo think its stress related. or nerves in my case, its a vicious cycle for me. Im fine when im at home and in my "safe" environment, take me out of that and im stuffed. Before going to a restaurant or whatever i am really nervous of what "might" happen so that makes me wanna stay home.. I cant stay home for the rest of my life though. And 7lil ur so lucky u were able to go on holiday, i went away last year and on my flight from perth to singapore i had a panic attack and that nearlyyy ruined my whole 5 weeks away in europe cos i was sooo nervous for the rest of the holiday and all the other flights i had to take... funnily enough i have good memories of the trip haha Weird since i spent most of it visiting toilets around europe haha
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Veteran Member
Date Joined Mar 2006
Total Posts : 1451
Posted 6/18/2006 2:52 PM (GMT -7)
Lat night I put a heating pad on my back and it helped the pain a great deal. I also find that when I have done a lot of lifting that I have a problem. I am still taking the Probiotics which is why this is a surprise and I think it is mainly stress related. This too will pass. usually I am constipated. this time it was diahrea but it seems to be settling down. thanks for your good wishes. Plan to have a no stress week this week.
Bella, maybe you should write a guide books to the best "johns" to visit. I envy you guys that can travel a lot. I can afford it but because of my emphysema it is really harder to travel as I must have O2 on the plane. Don't need it on the groung but I also don't like traveling alone anymore and it never used to bother me. I have done a lot of traveling so I did get my share in though so have fun, y'all while you can. I am lots older than you all also.
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Veteran Member
Date Joined Jun 2005
Total Posts : 2976
Posted 6/20/2006 7:56 AM (GMT -7)
Canyon, why not look into tour groups so you don't have to go alone? My grandmother went on a trip to Hawaii, oh, I guess right after I was born, and she still talks about
it a lot. She went with a big group. A lot of time churches will get a group of people together, especially seniors, to go somewhere. My Aunt's church always went somewhere in FL late or early in the vacation season and they had a good time. My college alma mater even arranges trips for alumni to band together on. It's a good way to make friends and if you go with people your own age, you certainly won't feel alone in needing to go to the bathroom all the time, although it may make for some long lines!
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Veteran Member
Date Joined Mar 2006
Total Posts : 1451
Posted 6/21/2006 3:23 PM (GMT -7)
I don't like group travel. I know it sounds unreasonable but with my breathing problems I cannot be subject to the schedule of other people. I don't have the bathroom problem as I have IBD-C but it is the need for oxygen which is the problem for me. I have to pace myself and so need to plan my own schedule which can be adjusted to my daily breathing health. I live in a Senior Mobilehome park and am busy all the time with seniors but I can't expect anyone to adjust to what I need now. I took 3 trips last year, 2 with stepdaughter and one to 50th reunion back east and that was fine but the regular tour things just won't work and cruises have become too difficult. When you get into your 70's and have chronic condition you do what is comfortable now and look close to home for fun most the time. If my husband were alive it would be different but i can't ask that of other people.
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Veteran Member
Date Joined Jun 2005
Total Posts : 2976
Posted 6/22/2006 7:41 AM (GMT -7)
I'm not trying to sell you a tour package or anything, but I would think that a tour group made up of nothing but seniors would include some other people with oxygen needs as well. And they're not exactly going to be hitting it at a hard pace with a bunch of grandparents on board. Just seems a pity that you like to travel and could but for the fact that you feel like a burden. You're obviously not up on the typical senior's outlook of entitlement! Burden? What did all of you seniors reproduce for if not to have someone to take care of you when you got old? It's time to cash in on those diaper changes and late night floor-pacing. And it doesn't even have to be your own children that you extract this debt from; there are plenty of grandparent-less young people out there that owe a debt.
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For many years, David Lynch has been my favourite film director and no-one else came close. My favourite film is Lost Highway and until I rediscovered Krzysztof Kieslowski last year, no other film came close. Melbourne Cinémathèque's partial retrospective offered a great revision of the Colours trilogy as well as some of Kieslowski's earlier films. Perhaps I'm being sentimental, but I still can't knock Lost Highway off its crown. As I wrote about it previously, some kinds of movie magic can only happen once, and for me that was Lost Highway. No other film has affected me to the same degree.
And yet, Kieslowski's films are so sublime, meaningful and personally affecting that I have to acknowledge his ascendency in my personal estimation. His entire body of work is so awesome, so full of ideas, explorations of human complexity and conundrums. This year I watched Dekalog on DVD and was amazed at the staggering accomplishment (I hope Melbourne Cinémathèque screens it one day - I've suggested it, but I won't hold my breath waiting). As I mentioned in my review of 2007, Three Colours: Blue is the first film to come close to Lost Highway in my all-time favourites.
What is it that Lynch and Kieslowski have in common as film-makers? On the surface, not a real lot, but underneath I think there's some similarities. Lynch explores the bizarre, depicting stories that often don't appear to make a whole lot of sense. They're like abstract works of art that don't necessarily have explanations, or even need them. When there is an explanation, one doesn't need it to enjoy the film.
Kieslowski's films are usually highly stylised social realism, with not a touch of Lynchian fantasy. Yet both directors are men who reportedly have a deep sense of spirituality, away from religion, but are never overt about their personal beliefs in their films. You generally cannot extract a direct message from them. I find both directors' works exude a deep sense of humanity, albeit in very different ways. In writing this, I suppose I'm exploring the connections myself.
Lynch appeals to the inner artist in me; his films speak to me on the level that art is important, and the artist's perspective is important. We live in a world where logic, reason, empiricism and economic realities rule. Lynch's work defies this and I love that we can see films like this, that push and challenge us. Kieslowski's films directly address the social and humanistic values that are the core of my personal values. If I could make films like any one director, I wish I could make them like Kieslowski's. Most of them are near flawless, intellectually, emotionally, humanistically, technically and aesthetically. His films epitomise everything that is most dear to me about cinema, and he does it in a way that is aesthetically pleasing, visually and aurally. So these two directors between them encapsulate important dimensions that represent the essence of cinema for me.
The above might seem like a fairly long preamble. It's something I wanted to get out of my system, and it has relevance to my end-of-year lists. Like last year, I've compiled separate lists for theatrical, festival and retrospective screenings. People like to compare lists (I certainly do) and it just seems more convenient and natural to divide them in this way. It makes it easier for me to compare films. With my lists below, I'm finding it more appropriate to group films rather than rank them absolutely, just like I can't really rank Lynch and Kieslowski relative to each other.
And here's a digression. Today was an important milestone for me on a personal level. Since my older son, Abhi, took his life just over two years ago, the bed he slept in when he regularly stayed with me has been unmade, exactly as he left it. It's been something that I've been unable to deal with or perhaps I've been holding onto, that I could smell him if I chose to, even though until today I didn't. And when I did, it brought tears to my eyes momentarily. Today I washed the bedding. It felt significant to me, and I just wanted to mention it. That's all.
So here's my picks of 2008:
Gus Van Sant has been one of my favourite American directors since Elephant, which until this year, was my favourite of his. I can't say I like Paranoid Park more, but I certainly don't like it any less. I love the subtlety of Paranoid Park and the fact that subsequent viewings enhanced my appreciation each time - this is the first film I've seen three times on the big screen during its theatrical release. The film looks terrific (with top notch cinematography by Christopher Doyle and inspired editing by Van Sant), the use of music is terrific, the characters are so authentic and the story is so moving.
Tony Gatlif's Transylvania is to Paranoid Park what Lost Highway is to Three Colours: Blue. They are so different but both so compelling that I can't separate them. They are my equal favourite theatrical releases of the year. I've loved everything I'm seen by Gatlif and I really should look out for his back catalogue. I love the cultural and cross-cultural elements of his films, the way he weaves music into his narratives and his documentation of the way of the Roma (gypsy life). Transylvania did all these too, but seemed to be much more effective than his earlier films. Maybe it was his casting of Asia Argento (reportedly the first time his main protagonist has been female). Maybe it was the multi-cultural aspect: an Italian from France travels to Romania to find the father of her expectant baby, hooks up with a German and... it's around here that I'm lost with all the cultural cross-roads, but I love it. There are some truly inspiration visuals and the film had me in tears more than once.
BTW, Paranoid Park is also the film I got to write a review for and get paid. I had a small piece published in The Big Issue (issue #299 from memory).
I've noticed people complaining about the quality of theatrical releases this year, but I think that complaint applies more to mainstream films, especially so-called blockbusters. It's been a struggle for the arthouse cinemas to get bums on seats for the serious films, which I find disappointing. Many niche films had short runs or screened only in Sydney, or straight to DVD. I'm not sure why support for truly arthouse cinema is waning, but I'm hoping it's cyclic and that people will tire of a dearth of variety and get back to those cinemas that take a few risks. Nonetheless, I'm quite happy with the overall quality of my top 10 theatrical releases.
For what it's worth, my nos. 3-6 are pretty much on a par, and little separates 7-10.
1. Paranoid Park (Gus Van Sant, France/USA, 2007)
1. Transylvania (Tony Gatlif, France/Romania/UK/Hungary/Italy, 2006)
3. Auf der anderen Seite (The Edge of Heaven, Fatih Akin, Germany/Turkey/Italy, 2007)
4. Persepolis (Vincent Paronnaud & Marjane Satrapi, France/USA, 2007)
5. Happy-Go-Lucky (Mike Leigh, UK, 2008)
6. Waltz with Bashir (Ari Folman, Israel/Germany/France, 2008)
7. La graine et le mulet (The Secret of the Grain, Abdellatif Kechiche, France, 2007)
8. Le scaphandre et le papillon (The Diving Bell and the Butterfly, Julian Schnabel, France, 2007)
9. Hunger (Steve McQueen, Ireland/UK, 2008)
10. Du levande (You, the Living, Roy Andersson, Sweden/France/Germany/Denmark/Norway, 2007)
Special mentions:
Little separates these from my no.10. Grindhouse was a guilty pleasure, some of the best fun I had in a cinema all year.
Youth Without Youth (Francis Ford Coppola, USA/Germany/Italy/France/Romania, 2007)
Planet Terror (Robert Rodriguez, USA, 2007)
Death Proof (Quentin Tarantino, USA, 2007)
OK, I'm a festival junkie. I go to as many festivals as I can, maybe even more. I love the cultural aspect and I love seeing the best of what the world has to offer. This is always a solid part of my cinema experience. There's little to separate my nos. 1-3, 4-6 and 7-10. In 2006, Nuri Bilge Ceylan's Iklimer (Climates) was my MIFF favourite and the Dardenne brothers' L'enfant (The Child) was my overall favourite. This year their respective offerings compete neck and neck.
Azur and Asmar was a surprise favourite of the French Film Festival. It's a children's film and, like Ocelot's earlier film Kirikou and the Sorceress, it's just as enjoyable for adults. Ocelot's films are very well written, very moving and very thought-provoking. They're inspirational for children. Azur and Asmar is one of the most visually stunning animated films you'll ever see.
1. Üç maymun (Three Monkeys, Nuri Bilge Ceylan, Turkey/France/Italy, 2008)
2. Le silence de Lorna (Lorna's Silence, Jean-Pierre Dardenne, Luc Dardenne, Belgium/France/Italy, 2008)
3. Azur et Azmar (Azur and Azmar, Michel Ocelot, France, 2006)
4. Milyang (Secret Sunshine, Lee Chang-dong, South Korea, 2007)
5. Stellet licht (Silent Light, Carlos Reygadas, Mexico/France/The Netherlands/Germany, 2007)
6. Hofshat Kaits (My Father, My Lord, David Volach, Israel, 2007)
7. Omiros (Hostage, Constantine Giannaris, Greece, 2005)
8. O' Horten (Bent Hamer, Norway, 2008)
9. Chacun son cinéma (To Each His Own Cinema, Various, France, 2007)
10. Izgnanie (The Banishment, Andrei Zvyagintev, Russia, 2007)
Special mentions:
Katyn (Andrej Wajda, Poland, 2007)
L'année suivante (The Year After, Isabelle Czajka, France, 2006)
I spoke to Constantine Giannaris, director of Omiros (no. 7 in the above list), who highly recommended the film that is my favourite in this section. The Mother and the Whore is simply sublime, full of intellectualisation (and pseudo-intellectual rants), nihilism and lament, culminating in an emotionally devastating and ambiguous ending. I love the title, especially the original one in French.
Cassavetes features heavily in this category, thanks to an ACMI retrospective. I also got to see a few Satyajit Ray films from his retrospective at the Indian Film Festival at the Nova. These are all well-known films below and there's not much I can add to what has already been written about them.
1. La maman et la putain (The Mother and the Whore, Jean Eustace, France, 1973)
2. Moartea domnului Lazarescu (The Death of Mr. Lazarescu, Alexandru Munteanu, Romania, 2005)
3. Shadows (John Cassavetes, USA, 1959)
4. Pather Panchali (Song of the Road, Satyajit Ray, India, 1955)
5. Le ballon rouge (The Red Balloon, Albert Lamorisse, France, 1956)
6. Faces (John Cassavetes, USA, 1968)
7. A Woman Under the Influence (John Cassavetes, USA, 1974)
8. No quarto da Vanda (In Vanda's Room, Pedro Costa, Portugal/Germany/Switzerland/Italy, 2000)
9. La passion de Jeanne d'Arc (The Passion of Joan of Arc, Carl Dreyer, France, 1927)
10. Stalker (Andrei Tarkovsky, USSR, 1979)
Special mentions:
The Killing of a Chinese Bookie (John Cassavetes, USA, 1976)
Apur Sansar (The World of Apu, Satyajit Ray, India, 1959)
Kanal (Andrzej Wajda, Poland, 1957)
2008 hasn't been a great year for Australian films. My favourites have been Three Blind Mice (expect to hear about a release date in the new year), Son of a Lion and The Square, though nothing rates high enough to make into any of the above lists.
The year also marks a serious attempt by a player to challenge the paradigm that Australia makes crap films that no-one wants to see. Unfortunately, the tall poppy syndrome - a concept I until recently never used to subscribe to - really kicked in and every critic and his dog was keen to tear Baz Luhrmann off his cocky high horse and make him eat their shit. People are entitled to dislike a film but thhe venom and vitriole that floated around both the print and online media was unparalleled in my experience, and I've lost some faith in the quality of film criticism in this country. I feel it was an opportunity lost and no studio is going to take a risk like that anytime soon, not because the film was that bad, but because of the critical response.
Sure, Australia is a film with problems (but then, so does The Dark Knight), but it also has a lot going for it. A showing metric is that Metacritic ranks critics' reviews of Australia at 53% (quite low) but other users at 7.2/10, almost the same as IMDb (7.3). Here's a case where the critics and the audiences are divided. Unfortunately, the irrational frenzy with which local critics panned the movie would have kept significant numbers away. But those who did see the film obviously enjoyed it. I certainly did, and it improved on a second viewing.
I saw 274 films this year, 241 on the big screen and 33 DVDs. This is slightly down from 2007 (297/283/14). I never used to count DVDs, but I've decided to include them now as I see a few festival screeners. With the Boxing Day releases looking pretty shabby, I'm not expecting to see any more films in a cinema until the New Year, though I'll watch quite a few DVDs to make up for it.
Here's looking to 2009. May the new year bring whatever each of you deserves.


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AIVEE Hub front MTB Edition 1 for 15x100 mm Thru Axle
Article details
AIVEE hub front MTB Edition 1 for 15x100 mm thru axle
The French manufacturer has Aivee his background in aerospace technology, and medical technology. Their hubs are manufactured in-house in France. They are characterized by an attractive price-performance ratio and high individuality.
The Edition 1 are the highend hub in Aivee range. Machined from 7075 T6 aluminum, it brings the front wheel hub to a weight of 117 grams lean. With its optimized geometry with chamfered hub flanges they can withstand high spoke tensions and ensures a rigid and durable wheel. Double-sealed bearings made in Japan EZO specialists in combination with a developed Aivee fat prevent the ingress of dirt and guarantee an excellent long-term performance. Available hubs are black or red anodized with 28 or 32 spoke holes.
Do you like to create an offer for a complete custom wheelset with rims and spokes of your choice. Just send us an email to email@example.com !
Technical specifications:
intended use: Cross Country, Marathon, All Mountain
Material: aluminum 7075 T6
bearing: 2 times
Achsstandard: 15x100 mm thru axle
Bremscheibenaufnahme: 6 hole | IS 2000
Hole number: 28 or 32
Color: black or red
Weight: 117g (manufacturer)
|Product weight:


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Gemma Hampton
My Profile
Hi everyone, my name's gemma hampton I am 27 years old and am raising money for Macmillan Cancer support. I am holding a coffee morning 28th september and selling raffle tickets to which am hoping to get donations of prizes for. Many people in my family have had a form of cancer or died from it most recently my boyfriend's dad who we lost a couple of days ago so this is a charity close to my heart so please help me raise lots of money.
Friend Request
has been sent a request to be your friend.
Total money raised so far: £0.00
My Friends
Become the first Charity Choice friend of Gemma.


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31 Watercress, Irvine CA, 92603 (Residential)
Sold Price:
4 beds , 5 Full/2 Half baths
6,450 sqft
Status: Sold
Last Updated: 11/25/2017 1:19 AM
Description for 31 Watercress Irvine, CA 92603
Panoramic views in this beautiful custom estate in exclusive Shady Canyon. 4 bedroom suites, 4 and 3 half-baths.
Sold Price:
Sold Date:02/23/2015
5 Full/2 Half
6,450 (approx)
Panoramic views in this beautiful custom estate in exclusive Shady Canyon. 4 bedroom suites, 4 and 3 half-baths.
Listing Information
Public Water Service
Sewer at Street
School Information
Room Information
Family Room, Living Room, Foyer, Guest Room, Office, Media, Utility Room, Walk-In Pantry, Wine Cellar
First Floor Bedroom, Master Suite, Walk-In Closet
Interior Features
Range/Oven Built-in, Dishwasher, Double Oven
Hardwood, Stone
Central Air
Forced Air
Foyer Entry
Family Room, Living Room, Master Bedroom, Outdoor Fireplace
24 Hour Security, Alarm -Smoke/Fire, Guard At Gate,
Breakfast Bar, Cathedral/vaulted Ceiling, Crown Molding, Granite Counter Top, Kitchen Island, Pantry, Recessed Lights, Stone Counter Top, Wet Bar, Foyer Entry, Fire Sprinklers
Exterior / Lot Features
4 Garage Spaces, 4 Parking Spaces
Community Pool, Private, Saltwater
Community Spa, Private Spa
Hill, Canyon
BBQ, Biking/Fitness Trail, Storm drains
Community Features
Community Spa, Community Pool, Community Tennis
Driving Directions
Shady Canyon Drive to Sage Creek, right on Watercress
Financial Considerations
Listing Price History
Irvine Real Estate
Irvine is located in California. Irvine, California 92603 has a population of 256,927.
The median household income in Irvine, California 92603 is $91,999. The median household income for the surrounding county is $75,998 compared to the national median of $53,482. The median age of people living in Irvine 92603 is 34 years.
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Wether you're independant or a signed artist performing from rock to rap between L.A. and Atlanta, we're the guys you've been looking for to produce your next music video. Check out a few videos below that the Bob's Eye View crew have put together. These are just a small taste in comparison to what we are capable of doing. No project too large or too small.
Video and Social Networking is key to a succesfull business these days. Let us help you create a
professional video to promote your buisness. And post it over all the main Social Networking Sites. If you don't have a Web Site check out our partners at HOJO Studios.
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For further information on our awareness campaign click here...
Looking for something? Search the Prospect Hospice here:
Are you looking to challenge yourself? Fancy doing something you've never done before? Then join Team Prospect!
Every year, people take on challenges to raise vital funds for Prospect Hospice. From running their very first 10K, to climbing towering peaks, and jumping from planes – there are plenty of events to choose from. When you join Team Prospect and take on one of our exciting challenges, you will help us to provide top quality care to our patients and support for their families.
Take a look at what we have to offer and if you can't see a challenge that suits you, don't worry! Get in touch on 01793 816180 and we'll find an adventure for you.
If you've already found a challenge that you'd like to do, let us know what you're up to by completing this form so that we can offer you all the support you need.
We can't wait to welcome you to Team Prospect!
Running events
Challenges fundraising guides
Prospect 10k
Parachute for Prospect
Source to Sea
Feel Good-a-thon
Kilimanjaro 2017
Trek the Canyons 2018
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Sahara Mini Adventure Trek
London Marathon Walk
Hadrian's Wall Trek
Original Three Peaks
Run the Rainbow
Bear Grylls Survival Race
Ridgeway Run
Give with confidence - Prospect Hospice is registered with the Fundraising Regulator and has committed to the highest standards in fundraising.
Copyright Prospect Hospice © 2017 Email: email@example.com
Prospect Hospice is a working name of Prospect Hospice Limited. Registered Office: Moormead Road, Wroughton, Swindon, Wiltshire, SN4 9BY. A company limited by guarantee registered in England and Wales (1494909) and a charity registered in England and Wales (280093)


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Cambodia newsbrief - November 2017
Guidelines on the implementation of Withholding Tax (WHT) on interest payments by MFIs for overseas loans (Prakas No. 1129 MEF-BrK dated 27 October 2017)
Guidelines on the implementation of Withholding Tax (WHT) on interest payments by MFIs for overseas loans (Prakas No. 1129 MEF-BrK dated 27 October 2017)
Cambodia introduces transfer pricing rules
Revised Tax Base for Public Lighting Tax (PLT) (Prakas No. 976 MEF-BrK dated 9 October 2017)
Amendment to Article 7 of the Sub-Decree on the Establishment of a Social Security Scheme on Health Care for Persons Defined by the Provisions of the Labour Law
Cybercrime is an increasingly real threat to business leaders. How can you stay aware of your cyber security and data privacy risks while embracing opportunities for growth?
Technology overtook financial services as the world's largest sector by market capitalisation in 2016. By 2020, there will be nearly 7 connected devices for every person on the planet. Yet there are signs that investors' interest in tech start-ups are starting to fade. Is this simply a blip or is the honeymoon period finally over?
The long-term shift in global economic power from developed to emerging markets is one of the five megatrends transforming business and society. The winners will be those that are rigorous in choosing where and how to play.
As the dust starts to settle on the UK referendum of 23 June 2016 new challenges and opportunities begin to surface. One significant issue will be the impact that 'leave' has on talent and mobility for a professional generation that has come of age in a globalised world and places a premium both on flexibility and international experience. Will the UK be able to attract and retain the brightest and best talent when it leaves the EU?
© 2015 - 2017 PwC. All rights reserved. PwC refers to the PwC network and/or one or more of its member firms, each of which is a separate legal entity. Please see www.pwc.com/structure for further details.


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Answer cube
1 set of Answer cube stickers
The stickers are designed for YJ GuanLong cubes
The Answer cube is the creation of Sven Krugmann His own description of this cube sticker is the following:
Answer Cube
If you google "The answer to life the universe and everything" you'll get "42". Maybe you know the answer from the movie "The Hitchhiker's Guide to the Galaxy".
A Rubik's Cube have more than 42 Quintillion possibilities, but only one correct solution.
My "Answer Cube" have 2 solved states.
The first solved position is like the Dice Cube. The black and white dices forming a pattern in this position.
All numbers added in every line around the cube equals 42. (5+5+5+3+3+3+2+2+2+4+4+4=42; 1+1+1+3+3+3+6+6+6+4+4+4=42; 5+5+5+6+6+6+2+2+2+1+1+1=42)
The second solved state shows the numbers "4" and "2" on two sides in green and blue lines. On one side is a blue/green "42" like a domino. On this domino-side also every number added equals 42. And like the Dice Cube all numbers added in every of the 9 lines around the cube equals 42. On the other 3 sides is a little Maze.
Images and more info at Twisty Puzzles forum
Write a review
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ECF Artwork
All fine art is created by adult artists in our four Art Center program studios. The one-of-a-kind art pieces include watercolors, ink drawings, acrylic and oil paintings, and ceramic pieces. Many diverse styles and themes are represented to meet a wide range of art lovers' interests and tastes.
Our original art pieces make a great addition to office and home space décor, as well as ideal gifts for family, friends, and business colleagues. Proceeds from art sales benefit the adult artists in the Art Center program. 60% of each sale's proceeds goes directly to the professional artists when they sell a piece of art, and 40% is directed back into the Art Center program to offset art supplies and other program costs.
How to Purchase Art
Downtown Art Center (DAC) Gallery
Our DAC Gallery serves as a hub for exhibitions and sales of art produced at our four Art Center program studios located throughout Los Angeles. You can visit the gallery online at www.dacgallery.com or at its storefront location in Downtown Los Angeles (431 South Broadway, Los Angeles, CA 90013). Call (213) 627-7590 to schedule an appointment.
In 2013, the DAC Gallery became one of a limited number of galleries in the U.S. selected to join a new Amazon.com initiative called "Fine Art on Amazon." You can view and purchase over 2,000 pieces created by ECF artists on DAC Gallery's page at: www.ECFonAmazon.com.
ECF Art in Business Settings
We also welcome partnerships with representative buyers and buyers supporting consignment work. If you know someone who represents a business or corporation and is interested in purchasing quality original fine art, please contact us. We welcome the opportunity to introduce and feature ECF artwork in business settings. Please contact the DAC Gallery at (213) 627-7374.


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Sharing his 'Voice': After popularity of TV appearances, Nicholas David returns to Fargo
Fargo - No matter which one he's using, "The Voice" made Nicholas David a household name.
He went from playing for hundreds in small rooms to playing for millions in living rooms across the country in 2012 when he was a featured contestant on "The Voice" under the name Nicholas David.
Under coach Cee-Lo Green, The Twin Cities singer would finish third in the NBC talent show, but not before earning a reputation for his soulful rendition of "You Are So Beautiful" and "You're the First, the Last, My Everything."
David is back on the road and plays The Aquarium, 226 Broadway in Fargo, Thursday.
While he may not be on the TV screen anymore, David is back where he feels most at home, on stage and in the studio. Last fall he hit the road with his Feelin' Band opening for The Avett Brothers and he's been recording his own material.
Thursday fans can expect some of the songs that made him such a strong contender on "The Voice" as well as his own tunes, like last year's single, "Say Goodbye."
More importantly, they'll be able to see and hear the star up close.
If You Go WHAT: Nicholas David with Pat Lenertz opening
WHEN: 9 p.m. Thursday
WHERE: The Aquarium, 226 Broadway, Fargo
TICKETS: Tickets for this ID-only show are $20


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Ever since Kevin re-ignited my obsession with sneakers by getting me my pair of Oreos for Christmas, all I've been thinking about is buying more and more sneakers. It's an expensive hobby to have, but it's a fun one. Way back when, I cared about having a nice pair of sneakers just for gym class, but these days there are so many more uses for them. I like seeing how I can dress them up or down with different outfits, plus the Oreos I have (which I have not shared on the blog yet!) are the most comfortable pair of shoes that I own. So lightweight – stylish and chic.
I came across these one-line drawings the other day from the illustrators of Differantly Studios and had to share them. A lot of sneaker designs these days can be quite intricate which I do find intriguing, but these illustrations bring back the simplicity that can sometimes be lost. It's cool to see how even though these drawings are minimalistic, you can still tell exactly what they are.
Check out the rest of them here!


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Cannot access outlook email account
Whenever I connect to my outlook email account, the browser shous the outlook logo and the progress bar as the mailbox is being opened. The browser is then redirected to a plain text page looking like this:
(missing image with "Microsoft Account" text)
Terms of Use Privacy & Cookies Sign out
© 2017 Microsoft
and the url: account.live.com/ar/cancel?ru= and a very long string of gibberish.
This just began happening today, with no action on my part which might explain it.
The url I'm using to log in is https://outlook.live.com/
And I can log in without issue using the Chrome browser.


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Hot women are sending X-rated nudes to stop Donald Trump
A GROUP of female activists are sending totally naked selfies to anyone who votes against Donald Trump.
Women have been giving out sexy nudes of themselves in exchange for evidence of not voting Trump for president of the United States.
Tramps Against Trump, hopes to convince people to not vote for the Republican frontrunner with their saucy snaps.
The revealing pics show women with thier tops off and baring their derrieres.
Voters have to prove they did not vote for the billionaire businessman with photographic evidence.
"I wanna live in America lol"@GreyJawRipper
Tramps Against Trump's founder, who goes by the name Jessica Rabbit, said: "The sex positive activist community is uniting across borders to keep misogynistic men out of the government."
On the group's website page it says that women who are over 18 can get involved in the campaign.
In an interview with Dazed, Jessica Rabbit said: "We hope this kind of campaign will continue to translate in other countries all over the world."
The group has been given a lot of support since it was set up.
Twitter users have called it "one of the best ideas I've ever heard" and "contradictory, but genius".
Unfortunately for those who don't live in the US, nudes can only be exchanged for those who can actually vote in the election.
This prompted one Twitter user, @GreyJawRipper, to say: "I wanna live in America lol". [sic]
It appears that the group have hit some problems, as people appear to have tried to send fake pictures of voting receipts as proof.
tramps against trump has gotta be one of the best ideas i've ever heard— yung tuxedo mask (@IceColdDamu) June 28, 2016
"Tramps against Trump" the liberals are evolving. I've got to say, I honestly think the idea is genius. Contradictory, but genius.— Xach Helms (@HelmsZ) July 1, 2016
The activists posted on their Twitter page: "We know the difference between googled images vs. real selfies. Nice try tho."
And the group have got criticism from some online users.
One user, @Shelbsss_03, said "Lol y'all there is this group called 'Tramps Against Trump' and they literally couldn't be any more stupid…" [sic]
Lol y'all there is this group called "Tramps Against Trump" and they literally couldn't be any more stupid...— ShellBee (@Shelbsss_03) July 1, 2016
Jessica Rabbit revealed that she and her team enjoyed receiving angry messages from Trump supporters.
She said: "Trump supporters are so incredibly dumb – both politically and socially – that we literally sit around and laugh at the angry tweets.
"Where are our intellectual haters?"


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Family in Toronto
Hi there I am a single mother of two little princesses ages 3 and 4 and also doing daycare on the side.. if you are looking for a trustworthy honest reliable Babysitter I am located in north York and will be more than happy to look after your precious little ones.. I take care of children ages 1-4 Feel free to contact me via email or by phone at 647-216-... Thanks
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text: Hi all, I've installed MinGw and Msys 1.0, then I'm trying to compile the open-cobol source. The configure shell check for the gmp.h file. I've looking for the gmp library and I've found http://cs.nyu.edu/exact/core/gmp/, in wich there are the dynamic and static libraries compiled for MinGw. The question is: żHow can I install this libraries?, I've copied the files to /usr/lib /usr/include and /usr/info dir, but the configure shell don't found it. I know that it's a newbie question, but I haven't found information about this. Thank's in advance.


text:
Watch: Beauty YouTuber Fei Lives Every K-Pop Fans Dream In Recent Episode Of UP10TION, Please!
Beauty YouTuber heyitsfeiii is living every K-pop fans dream by meeting some of her favorite idols and has survived to tell the tale (in vlog form).
In Feis most recent vlog, the beauty YouTuber shows her viewers the behind-the-scenes experience of being on set with UP10TION for the most recent episode of the Zany TV and Soompi exclusive series UP10TION, Please!
Fei couldnt help but be a bit nervous, not only because the UP10TION members dont have a lot of experience with makeup, but also because of how close they were to her while applying her makeup (still swooning about Bitto and Kogyeol). Her reaction is priceless, but also completely and 100 percent understandable for any K-pop fan who has dreamed about this kind of scenario.


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Detroit, Mich., May 14. - The schooner ELLEN WILLIAMS, loaded with lumber and ties for Tonawanda, struck an obstruction in the Lower Detroit River yesterday and sank soon after in Callum's Bay on the Canadian side, where she was towed. She lies in 15 feet of water. Several vessels have reported striking something off the foot of Bois Blanc Island, but yesterday's accident is the first one to result in serious damage. The passenger steamer CITY OF DETROIT was one of those which found the obstruction.
The Buffalo Times
May 14, 1906
. . . . .
Detroit, May 14. - Schooner ELLEN WILLIAMS, bound down in tow of the tug MINER, struck an obstruction in the river near the lower end at the Bois Blanc Island yesterday morning, and in a short time sunk in 16 feet at water on the Canadian side of the river. The schooner was loaded with lumber and cedar ties for Tonawanda. She struck in about the same place as the steamers CITY OF DETROIT and CITY OF CLEVELAND did last week in the channel, and to westward of the ranges.
Buffalo Evening News
Monday, May 14, 1906
Schooner ELLEN WILLIAMS. U. S. No. 7308. Of 292.38 tons gross. Home port, Chicago, Ill.
Merchant Vessel List, U. S., 1869
The Maritime History of the Great Lakes site is managed by Walter Lewis
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text: From a knowledgeable insider comes the following: "The 3400 memory problem has very little to do with the thin design. It has everything to do with the PCMCIA card cage. We seen this problem on the 190's and the 5300's also. Apple doesn't always get the card cage flush on the motherboard when they mount them. It sticks up just a hair and puts pressure on the memory. The memory acts like a lever at that point and the first shock it gets, pops it out of the socket."


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This study was performed to elucidate the relation between in vivo measurements of two-dimensional principal strains and the progression of left ventricle (LV) wall thinning during development of dilated cardiomyopathy in the protein kinase C-ε (PKC-ε) transgenic (TG) overexpressing mouse heart. Principal two-dimensional strains, E1 and E2, were determined in the LV wall of the anesthetized mouse using cardiac MRI tagging at 14.1 T. PKC-ε TG provided a model of pure dilated cardiomyopathy without evidence of hypertrophy (PKC-ε TG, n = 6). Ejection fraction, wall thickness, and principal strains were determined at 1-mo intervals in hearts of PKC-ε TG vs. age-matched, nontransgenic mice (NTG, n = 5) from age 6 to 13 mo. Through the study, PKC-ε TG displayed lower ejection fraction than NTG. At 7 mo, average principal strain E1 in PKC-ε TG hearts was lower compared with NTG (PKC-ε TG = 0.14 ± 0.03, NTG = 0.19 ± 0.03, P < 0.05). The greatest reductions in regional E1 occurred in the lateral segments. The principal strain E2 did not change significantly in either group. At 9 mo, LV wall thinning occurred in PKC-ε TG mice (P < 0.01 vs. 8 mo) to 21% below values in NTG (P < 0.001). Average E1 strain diverged between PKC-ε TG and NTG hearts by 25–43%. These E1 changes preceded LV wall thinning and predated the eventual transition from a compensated circumstance to the dilated phenotype. The findings indicate a near step function in E1 depression that precedes the onset of LV wall thinning and suggest E1 as a prognostic indicator of dilated cardiomyopathy.
- protein kinase C
- magnetic resonance imaging
- ventricular function
dilated cardiomyopathy (DCM) is characterized by anatomical changes of the heart, including myocardial wall thinning (7). Functional abnormalities include impaired contraction with reduced stroke volume and ejection fraction (EF). This study focuses on the potential differences in principal strain between normal and thinned left ventricular (LV) walls. Few studies have explored the relationship between LV wall thickness and principal E1 and E2 strains that are important indexes of radial wall thickening and wall circumferential shortening. The few published myocardial strain measurements by MRI tagging in humans with DCM show consistent patterns of regional heterogeneity of myocardial strain (34) and severe reduction in fiber shortening (19). Variation of end-systolic wall stress in normal subjects and patients with DCM was also found using Cine MRI (10). In videofluoroscopy studies of motion of radiopaque markers implanted in LV of sheep, DCM was associated with circularization of the normally oval LV epicardium and with decreased magnitude of principal strains (27). Thus our aim was to monitor temporal changes in wall thickness in the protein kinase C-ε (PKC-ε) transgenic (TG) mouse for comparison of strain to that of normal nontransgenic (NTG) hearts.
Recently, our laboratory has reported significant improvements in MRI tagging resolution with 0.3 × 0.3-mm line separation and 0.1-mm line thickness by applying the DANTE (delays alternating with nutations for tailored excitation) tagging method of selective nuclear spin saturation, combined with fast gradient echo imaging at ultra-high magnetic field (14.1 T) (12). These improvements allow accurate measurements of regional principal strains E1 and E2 of both normal mouse hearts and, importantly, in the dilated mouse heart when LV thinning progresses to <1.0-mm thicknesses.
We have described and comprehensively characterized a mouse model of DCM, which is driven by constitutive and cardiac restricted overexpression of PKC-ε (11, 20, 24). These mice develop a gradual onset of LV contractile dysfunction, which progresses over 9–12 mo to a dilated cardiac phenotype. As such, this murine model offers an ideal content within which to study the changes in LV strain that occur along with these other established alterations.
We hypothesize that the progressive ventricular thinning over the course of the development of DCM affects principal strains compared with the normal heart and that this will provide insight into the hierarchical nature of myocardial (mal)adaptation. The hypothesis was tested with high-resolution cardiac tagged MRI by examining changes in LV wall thickness and two-dimensional (2D) principal E1 and E2 strains in the midventricular wall of the PKC-ε overexpressing mouse during progression of cardiac dilation.
Animal preparation.
Six male PKC-ε overexpressing TG mice (FVB/N strain, mean weight = 31.6 ± 2.0 g) and five age-matched NTG control mice (mean weight = 31.7 ± 1.8 g) were studied at 1-mo intervals, from 6 to 13 mo of age. The 6-mo start time was selected to correspond to the time of known onset of previously reported changes in myofilament biochemistry (11). A detailed description of the creation of the PKC-ε TG mice has been previously published (11). Animals were housed under controlled temperature, humidity, and light, with chow and water available ad libitum. All experimental protocols were approved by the Animal Care Policies and Procedures Committee at the University of Illinois at Chicago (IACUC accredited). The investigation conforms with the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health (National Institutes of Health Publication No. 85-23, revised 1996).
For imaging, anesthesia was induced in mice with 5% isofluorane and 100% medical grade O2 in a closed induction chamber (E-Z System, Palmer, PA). Thereafter, anesthesia was maintained with 1.0–1.2% isofluorane in 2 l/min flow of 100% O2 administered via vaporizer (SurgiVet, Waukesha, WI) and nose cone. Body temperature was measured rectally and maintained at 37 ± 0.5°C by continuous flow of warm water through surrounding Tygon tubing. Subcutaneous ECG electrodes were connected to a physiological monitoring system (SA Instruments, Stony Brook, NY) to provide cardiac triggering. Triggering pulses were blanked during inspiration to limit motion (4). Accidental scanner triggering from rising gradient-induced transients were blanked. At the end of each protocol, animals were warmed under an infrared heating lamp and, after full recovery, returned to cages.
1H anatomical and tagged cardiac imaging were performed on a pulsed nuclear magnetic resonance (NMR) spectrometer/imager (Bruker Medical, Ettlingen, Germany), consisting of 14.1-T, 89-mm vertical bore magnet, with a multinuclear Avance console equipped with a microimaging gradient system capable of 1,000 mT/m maximum gradient strength and 110-μs rise time. Crops of typical end-diastole and end-systole tagged cardiac images of a 10-mo-old PKC-ε mouse are presented in Fig. 1, B and C.
Anesthetized animals were restrained in a 24-mm inner diameter cradle designated to fit linearly polarized 600-MHz whole body, bird-cage NMR resonator (26 mm inner diameter and 52 mm length) and were situated vertically, head up, in the magnet.
Several factors influenced our decision to evaluate only a midventricular short-axis slice. First, cardiac MRI experiments at very high magnetic fields are prone to loss of the signal due to the susceptibility effect that causes local inhomogeneity of magnetic field (14). While this inhomogeneity can be reduced by elaborate and time-consuming manual shimming in the midventricular slice, our experience has been that it is very often not possible in the apical and basal regions. Furthermore, although complete imaging studies were performed at apex, midventricular, and basal levels, loss of the NMR signal on tagged images from the apex and base made these experiments only partially complete and impossible to process. Only the short-axis, midventricular slice provided consistent nondisturbed, high-resolution tagging patterns of 0.45 × 0.45 mm, allowing strain computation as well as unambiguous measurements of wall thickness.
A gradient echo fast imaging (GEFI) sequence provided long-axis plane and transverse plane scout images to localize the heart and to position the short-axis plane (Fig. 1A). Then the midventricular short-axis slice was located halfway between the apex and base, and corresponding anatomical and tagged images were acquired. To monitor the position of the heart over the entire experimental period, control horizontal long-axis images of the heart were acquired every 20 min.
Volumetric analysis was performed using seven to nine anatomical true short-axis contiguous slices (no interslice gap) that were taken at end diastole and end systole to cover the entire LV. Images were acquired using GEFI sequence with 1,000-μs sync excitation pulse, field of view 20 mm, slice thickness 1 mm, echo time 1.5 ms, flip angle 30°, acquisition matrix 128 × 128, and number of excitation 4. Repetition time was set to 100 ms and, due to cardiac gating, was equal to one RR interval and additionally was prolonged by blanking during inspiration. A GEFI sequence delivered rapid imaging in 2.37 ms with excellent myocardium-blood contrast and was not disturbed by the tagging grid, which makes delineation of ventricular structure less accurate.
Tagged images were obtained using a modified DANTE/GEFI sequence proved to be capable of producing very narrow tag lines in a relatively short time, thus making it particularly useful in a study of small-animal heart (8), where fast heart rate (HR) and small heart size require high spatial and temporal resolution of tagging (29). The tagging grid was generated by two composite pulses consisting of 12 hard pulses, 15 μs each, separated by 600 μs, with corresponding gradients in two orthogonal directions. Saturation of protons within tagging planes with very short radio-frequency pulses required maximum power available from 100 W/600 MHz transmitter. With tagging gradients of 88 mT/m, which is less than 10% of the available gradient strength, the sequence yielded a tag grid spacing of 0.45 mm and grid line thickness of 0.1 mm (covering 5.8 and 1.3 of 256 × 256 pixels, respectively). Immediately following the tagging interval, short-axis Cine frames were acquired with 8-ms temporal resolution and imaging parameters of repetition time 200 ms (effectively two RR intervals), echo time 1.9 ms, flip angle 90°, acquisition matrix 256 × 256, and number of excitation 4.
Image analysis.
Anatomical and tagged images were processed with a Matlab-based program (MathWorks, Natick, MA) to calculate wall thickness, cardiac volumes, and principal strains (17). To obtain regional values of wall thickness and strain, the myocardium was divided in four segments: septal, anterior, lateral, and inferior (5).
LV end-diastolic volume (LVEDV) and end-systolic volume (LVESV) were calculated from epi- and endocardial contours traced on short-axis gradient echo images taken at end-diastolic and end-systolic phases and described in details elsewhere (21, 26). LV mass was computed using the following equation: LV mass = ρ∑(epicardium area − endocardium area) × slice thickness, where ρ is density of myocardium, 1.055 g/cm3 (28). LV mass index (LVMI) was determined in each animal [LVMI (mg/g) = LV mass/body weight × 10]. LVEF was defined as EF = [(LVEDV − LVESV)/LVEDV] × 100%.
Figure 2 depicts centroids of the triangles used for strain analysis in four segments of the LV. Traces correspond to the complex motion (rigid body motion and deformation) of the myocardium tissue during the transition from end diastole to end systole. For calculating strains at end systole, a reference image was acquired at end diastole, and the image corresponding to minimal LV volume was assigned as end systole. Tagged images of 256 × 256 original resolution were zero-filled and reconstructed to a 512 × 512 matrix. Relative displacement of tagging grid centroids was quantified. Finite-element, homogeneous strain analysis was used for calculation of 2D regional and average principal E1 and E2 Lagrangian strains (17). E1 corresponds to maximum elongation strain, and E2 corresponds to maximum compression strain.
Statistical analysis.
Comparison of mean values between PKC-ε TG mice and age-matched, wild-type NTG mice were performed using the two-way ANOVA with Bonferroni posttest. Intragroup comparisons were performed using repeated-measures parametric one-way ANOVA with Tukey's multiple-comparison posttest (GraphPad Software, San Diego, CA). All data are presented as means ± SD, with statistical significance at <5% probability.
Cardiac function.
No animal mortality occurred over the course of the 8-mo study. HR was unchanged in both groups of anesthetized mice over 8 mo, ranging from 424 ± 45 to 497 ± 37 beats/min in NTG and 441 ± 39 to 476 ± 48 beats/min in PKC-ε TG hearts.
Analysis of LV mass (Fig. 3A, top) shows significant changes in mass within the NTG group during the first 3 mo of the study (6–8 mo of age) and no changes within the TG group. Comparison of LV mass between both groups disclosed significant differences only at 6 mo of age. Normalization of LV mass by body weight (LVMI) amplifies the differences between groups at 12 mo (Fig. 3A, bottom).
Although LVEDV in the NTG group increased gradually between 6 and 9 mo, it remained the same within the PKC-ε TG group during the entire study (Fig. 3B). Relative to the NTG, LVEDV in PKC-ε TG was significantly higher at 6–8 mo of age, as was LVESV from 6–13 mo. In PKC-ε TG, this high LVEDV remained unchanged, while LVEDV in NTG mice gradually increased over 6–9 mo.
While EF of NTG hearts was comparable to previously reported values for normal mice (13, 18, 22, 30, 32), monthly comparison (Fig. 3C) revealed consistently lower EF in PKC-ε TG than NTG (P < 0.001), as previously reported for mouse hearts with DCM (16).
Myocardial wall thickness.
Analysis of the diastolic anatomical images at the midventricular level of PKC-ε TG and NTG mice shows comparable values of average diastolic wall thickness from 6 through 8 mo of age (Fig. 4A). At this time, both groups present similar heterogeneity of regional wall thickness with anterior segment dominant (P < 0.05). Figure 4B illustrates regional wall thickness measured at the beginning of the study (6 mo) before wall thinning in PKC-ε TG.
At 9 mo of age, a thinning of the LV wall of PKC-ε TG mice was abruptly evident compared with that of the previous 6- to 8-mo period (Fig. 4A). Average wall thickness was reduced in PKC-ε TG (P < 0.003), with no difference occurring among NTG hearts (P > 0.1). Average wall thickness in PKC-ε TG was 21% below that of NTG values (PKC-ε TG = 0.90 ± 0.12 mm; NTG = 1.14 ± 0.14 mm, P < 0.001) and marked the onset of changes in the morphology of PKC-ε TG hearts. Additionally, at the 9-mo time point, regional wall thickness of the PKC-ε TG developed a near uniform distribution in wall thickness, which was in contrast to the shape maintained in the NTG hearts, with the thickest segment being anterior. Beyond this 9-mo time point, average and regional wall thickness in both groups of hearts did not change. Figure 4C displays regional wall thickness for both groups of mice at the end of the study (13 mo) following wall thinning in PKC-ε TG.
Myocardial strains.
Importantly, differences in 2D LV wall E1 strain between experimental groups precedes significant LV wall thinning in the PKC-ε TG hearts. As shown in Fig. 5A, values of average E1 in the two groups diverged at the 7-mo time point (2 mo before the wall thinning seen in the TG group), maintaining an ∼25% difference over the remaining 6 mo of the study. Figure 5, B and C, displays segmented E1 strain values during the prethinning period (6 mo) and following thinning of dilated PKC-ε TG (13 mo) and illustrates the trend in regional E1 strain changes, with the lateral segments providing the dominant contribution to average strain from all segments, as summarized in Table 1. A significant increase of the lateral E1 in NTG hearts occurred over time, but not within the TG group.
In contrast, the magnitude of both the average and regional E2 strains did not change over the 8-mo study period in either NTG mice or PKC-ε TG mice (Figs. 6). Although magnitudes of E2 for PKC-ε TG did remain consistently below those of NTG hearts, no significant differences in E2 were established between the two groups.
While focusing on the relationship between potential changes in 2D principal strains in the LV wall of the heart and LV wall thinning, the present study offers a comprehensive analysis of the development of DCM in hearts of mice overexpressing PKC-ε. Lower EF at 6 mo in PKC-ε TG mice vs. NTG indicate that the compromised cardiac function that is induced by this genetic modification presents earlier than previously appreciated using more conventional echocardiographic imaging (11). This observation may be due to the relatively high resolution of the MRIs compared with previous evaluations using other methods. Differences in EF between groups did not occur as a consequence of age and, in PKC-ε TG mice, preceded changes in E1 strain and LV wall thickness at midventricular level.
Midventricular wall thickness within the PKC-ε TG group dropped significantly at 9 mo of age (Fig. 4A). However, EF, LV epi- and endocardial volumes, and LV mass remained unchanged (Fig. 3). This result highlights the importance regional, as opposed to global, factors that influence the geometric progression toward cardiac dilation.
The study indicates that E1, but not E2, strain was reduced during the development of DCM, and this change was temporally linked to subsequent thinning of the LV wall. At 9 mo, LV wall thinning in TG mice affected the septal, lateral, and primarily anterior segments. The lateral segment has the highest E1 principal strain in normal LVs. Interestingly, the regions displaying the greatest magnitude of E1 strain in normal LV also displayed the greatest difference in E1 compared with the dilated LV of PKC-ε TG hearts. In relation to NTG mice, lateral E1 strain in TG mice was smaller by 30–100% between 7 and 13 mo (Table 1), the biggest difference among all four identified segments. However, segments showing the greatest difference in E1 strain were not those displaying the greatest reduction in wall thickness. The observation that both preexisting differences in EF and the divergence of E1 between groups preceded LV wall thinning in dilated hearts suggests that strain changes are more closely linked to the development of cardiac dysfunction than later stage changes in wall thickness.
A recently published cardiac MRI tagging study of children with Duchenne muscular dystrophy showed similar differences in average and regional midventricular strains compared with controls (1). Duchenne muscular dystrophy is associated with progression, often undetected, to DCM during adolescence. The study links changes in myocardial contractility expressed in the early decrease of strains with gradual loss of sarcomeres.
Interestingly, average and regional principal E2 strains were similar in both NTG and PKC-ε TG mice and did not change with age. This suggests that the strain associated with compression is not compromised in the myocardium during the onset and progression of this DCM. Indeed, impairment in E2 may well be more likely associated with and predictive of a hypertrophic than a dilated phenotype.
Regional E2 strain in NTG control mice was more homogeneous than E1 strain, with no dominant contribution from any one segment. This finding is consistent with previously published studies of normal C57 mice (35). Figures 5, B and C, and 6, B and C, show representative regional E1 and E2 strains before and following LV wall thinning in PKC-ε TG hearts.
We have studied many aspects of the molecular phenotype of this PKC-ε overexpressing mouse, and increases in β-myosin heavy chain (MHC) proved to be one reliable indicator of the underlying contractile dysfunction (11, 20, 24). It is now well appreciated that, in normal myocardium (both rat and human), there is a gradient of expression from endocardium to epicardium of several biochemical components; critical among these are the MHC isoforms and myosin light chain kinase (2–4, 25). As regards MHC, Stelzer et al. (25) have argued persuasively that small gradients of expression seen across species from rat (3) to human (2) are likely responsible for the timing of force generation and for maintenance of coordinate and forceful contractility. Conversely, loss of this gradient, which is seen in almost all models of DCM, would result in a slowing of the stretch activation response and would significantly slow the rate of force development during systole and diminish both stroke volume and work production during ventricular ejection. This would be reflected by precisely the strain changes seen in our present study.
There are few in vivo murine cardiac magnetic resonance studies conducted in vertical bore magnets. Work by Schneider et al. (23) at 11 T concluded that vertical bore magnet systems can be used for accurate measurement of cardiac functions in normal and failing mice. Wiesmann et al. (31) reported no significant differences in hemodynamic values obtained from either horizontal or vertical positioning of mice. However, there are no reports of principal strain measurements in murine hearts conducted in vertical bore magnets. Although the first 3D motion mapping of murine myocardium with phase-contrast MRI in 17.6-T vertical bore magnet has been published (14), it does not offer any strain-related data. To date, the consequences of prolonged upright body position in anesthetized animals on cardiac strain measurements remain purely speculative.
Systolic E1 and E2 strains obtained with the DANTE tagging method in this study for the NTG group are slightly smaller than previously reported results in normal mice held in a horizontal position with HR maintained around 500 beats/min (35). The differences between previous work and this present study, although within experimental error, are due to the use of spatial modulation of magnetization spatial coding method that inherently produce tagging grids faster than DANTE but at the cost of tagging resolution.
Of considerable clinical interest is the possibility that localized changes in E1 strain in the TG hearts (Table 1), which result in a more homogeneous distribution of strain across the heart, would lead to changes in LV geometry. This measurement, generally determined echocardiographically, has long been felt to represent a marker of progressive systolic dysfunction and to predict the onset of LV decompensation and functional mitral insufficiency (15, 33).
In summary, we investigated the fundamental role of myocardial stretch in active cardiac contraction (9), from temporal analysis of regional, 2D strain changes in the thinning LV myocardium (<1 mm) of a murine mouse model of DCM. High-resolution magnetic resonance tagging revealed a divergence of E1 principal strain between DCM and normal control hearts that preceded detectable wall thinning in the midventricle of the PKC-ε TG mouse heart, presaging the eventual transition to the dilated phenotype and, eventually, heart failure. The observation that changes in strain predate the geometric remodeling associated with thinning of the ventricle implies that dysfunction at the level of the myofibril is causative. Our findings suggest that monitoring of E1 can provide quantitative assessments of LV function during the progression of DCM before significant changes in LV wall thickness. This approach may potentially provide an imaging strategy to direct the timing and anatomical location of therapeutic interventions.
This work was supported, in part, by National Heart, Lung, and Blood Institute Grants RO1HL62702, R37HL49244, and PO1HL62426.
Present address of P. M. Buttrick: Division of Cardiology, University of Colorado Health Science Center, Denver, CO 80045.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2008 by the American Physiological Society


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The Real Life of Alejandro Mayta is an astute psychological portrait of a modern revolutionary and a searching account of an old friend's struggle to understand him. First published in English in 1986, the novel probes the long and checkered history of radical politics in Latin America.
Despair hangs over this somber novel, a desolation as omnipresent as the garbage dumped on the streets of the author's native Lima. The setting is Peru in the near future, a military dictatorship besieged by Cuban-backed rebels and defended by U.S. Marines. An unnamed writer interviews people who were involved with his former classmate, Mayta, an idealistic radical whose journey through the various sects of the Peruvian left eventually led to his participation in a pathetic, doomed uprising in 1958. The writer seeks to understand what prompted Mayta to make this futile gesture, but finds only a tangle of disputed facts and self-serving statements; Mayta, he is told, was a homosexual, a police informant, even a thief. What is the truth? "Since it is impossible to know what's really happening, we Peruvians lie, invent, dream, and take refuge in illusions . . . Peruvian life, a life in which so few actually do read, has become literary.'' Readers acquainted with the author's previous work will recognize this as a central theme in all his writing, but not even in The War of the End of the World was it stated so flatly, so bleakly. The sourness and hopelessness of Vargas Llosa's vision are sadly appropriate to the terrible situation in Latin America today, but they give the novel a mean tone that's difficult to appreciate. Mayta is a book one can admire and respect without really liking it very much.


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width of 23-242 bottom track
A home owner says:
November 18, 2015
how wide is these tracks. 3inchs I hope?
Tom from SWISCO responded:
November 18, 2015
We actually show the size of the profile on the 23-242 store page. I will post it here for your convenience.
Keep in mind that total width is not as important as the distance between the two rails.


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John Lucas from Leominster UK to Australia abt 1880
John Lucas came to Australia abt 1880, he married Sarah Gregor in Sydney NSW in 1881. They had five children "ANNIE, LILY, OLIVE(MAY),
WILLIAM, (who died as a child)and JOHN(known as JACK)who was killed in 1918 in France in WW1. I am looking for any descendance.
Surnames: NONE
Viewed: 901 times


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ActiveDen Teen Boy Pack 12 movements 99313
Flash Template \ Animations \ Animated Objects
Flash Template - Teen Boy Pack (12 movements) 99313 by Kontramax @ ActiveDen
Flash Template \ Animations \ Animated Objects
ActionScript Version: AS2; Documentation: Well Documented; Flash Files Included: Flash FLA; Opens With: Flash CS3 (9+); Published Size: 80kb Resolution: 590x300
- Set of 12 silhouettes movements, fine vectorized and separated by elements.
- You can change any colors or effects in any part of teenager (hair, eyes, shirt, pants, skin, shoes, headphones and shadow).
- Fully vectorized and finished by handwork allow flexibly resize animation with fine quality of trace.
- Just copy/paste animation movieclip into your project and change style using filters or blend modes.
- Four footsteps (slow, fast, run, in phones) and three camera points of view (front, side, right).
- 4 color variations (like in preview) and headphones sound loop also included in archive.
- In all there 13 different FLA files in archive (animations + color variations).
- 24 fps
- Help file
Files included:
Key Words: 3d, boy, colorful, customizable colors, cycle, footstep, men, pack, separated, silhouette, teen, traced, vectorized, walk.


text:
Two great intro decks with one core and the expansions
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One persons journey on finding ways to save money. Thrift shopping for finds, up cycling and recycling vintage items. Finding ways to save money reusing vintage black and white photography for crafts. Save money by gardening and growing vegetables in Ocala Florida area. www.savingshouse.blogspot.com
Wednesday, June 26, 2013
Vintage Black White Photography for Crafts
Here are some beautiful vintage black and white photography that I had purchased on Etsy. These images are breath taking and I couldn't find a way to really part with them or reuse them in some collage.
|Landscape and river photo
|River and dock
|Vintage Beautiful overhead view of river
Posted by A.R. Cruz at 6:32 PM