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Oliver's 7th birthday fast approaches and he felt very strongly (cause that's the way Ollie feels things!) that he wanted to research motorcycles on the Internet and draw a unique one for each of his friends in the form of his birthday party invitations. Sometimes I feel just a bit stunned at this boy's artistic abilities and just wanted to take this opportunity to trumpet it around to all the land. I've mentioned how cool this little kid is, right?
Some Highlights From the Party
I always struggle with this so much. I want to share my life with you but for me, a vast chunk of my life involves my children. Unfortunately, I don't feel comfortable posting their pictures on the Internet. And so these distant-second-type photos will have to suffice:
We made miniature oven-baked clay sundaes. As you can see, the girls did an amazing job. They were careful and detail-oriented. One would, it probably goes without saying, never attempt this at a boy birthday party. For a whole variety of reasons.
The food. Minus the pizza. Again, you'll want to avoid this kind of thing at a boy party. They'd never notice or care and in a second and a half, the only evidence of all your hard work will be a smattering of crumbs. Oliver has already requested a Dairy Queen ice cream cake and that's A-OK with me. The girls eat all this up, though. Both literally and otherwise.
Lucy requested that each of her little friends bring along their favorite doll so as to provide her doll - Sophie - with the companionship she so richly deserves. High times were had in abundance. In both the human and non-human realms. (Don't do as JoyBoy did over and over again to his delight and suggest to the little ladies that their dolls are made of PLASTIC, of all things. He was indignantly informed that these little dolls are REAL. I can vouch for the fact that some of them have more elaborate wardrobes than I do, at any rate.)
Happy Birthday my beautiful brown Girl. You have richened my life immeasurably.
It's Birthday Season Around Here
It's birthday time around here. They're 13 and 11 respectively. I can't believe it.
Such a Therapeutic Conduit for Joy
Here are some sweet little girls (with their beautiful heads cut off!) for your viewing pleasure. Now you have some sort of a very vague idea of what Lucy and Anabel look like! They wear the scarves I recently knit for them, and which brought me so much joy. These scarves are riddled with dropped stitches, but my soul felt ministered to as I knit them. I only wish I'd jumped on to this Crafter's bandwagon long before.
I Love Cake!
I used to - in the height of my imagined elegance and very real ignorance - look down disdainfully on Crafters. I thought they were just the epitome of podunk-dom. I wondered how it was that these people couldn't find better things to do with their time when there were starving children in Etheopia, for pete's sake. Of course, as I contrasted my own young, naieve life which hadn't yet unfolded in any real way to theirs as I misjudged them, I felt stupendously superior. Ah. The fall from those dizzying heights of the arrogant early twenties.
Now if geekiness is defined by one's involvement in 'the Crafts,' <insert English accent here> I'm one of the very biggest. I make cakes for fun, I create cards and gift tags for joy, I scrapbook to document our fleeting lives together, I design bulletin boards at my children's schools for their teachers, I make somewhat unattractive chocolates, I'm a newbie knitter, and I'm very, very open to pursuing a whole lot more. I plan to look into making jewelry and to pursuing felting. I love being a geek; there's so much freedom there.
Oh Yeah. I'm a knitter! Oh Yeah.
I just learned to knit. I love it so much. And what's more, I don't even let JoyBoy's most recent derisive comment about the whole process faze me even a little. That man had the gall to tell me that Sex Vixens don't knit. What does he know about sex vixens, I ask? And so I knit. And then I do it again and sometimes I even purl, just to keep things fresh. As is my way, I need to have multiple knitting projects on the go to keep it interesting and so I'm working on two scarves for each of the respective daughters and two bad boy gigantic flower corsages just because they're different. I called them funky orange bastards to my sisters via email and as I hoped, they responded with just the sort of accepting and whole-hearted laughter that feeds my soul.
I'll show you those big orange bastards soon. They're really cool.


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OCEANSIDE -- Skulls and skeletons may abound on the Mexican holiday of Dia de los Muertos, but the ghoulish figures are hardly meant to frighten.
Depicted wearing stethoscopes, hard hats, dancing shoes or other tools that a person may have used in life, the often-whimsical skeletons show that death is just another stage of life.
This weekend, MainStreet Oceanside will be holding its own Day of the Dead festivities with a traditional fiesta that includes parades, music and food, as well as altars to the dearly departed.
MainStreet's fourth annual Dia de los Muertos festival will be held Sunday across four blocks of Pier View Way, from Coast Highway 101 to Nevada Street.
The street will drip with thousands of marigolds, the traditional flower for the celebration, and about 19 ofrendas, or altars, decorated with the favorite food, drinks and mementos of a dead friend or loved one, said Mary Ann Thiem, chairwoman of the event. The altars are built by 10 Oaxacan families as well as several school clubs and service organizations. The holiday is traditionally celebrated Nov. 1 and 2.
Thiem said that because each altar is a unique dedication to the dead, they are very interesting and touching to see.
"It's a celebration of life and death -- it's not Halloween, it's not scary," Thiem said. "We work very close with (the) Oaxacan community to make it authentic."
Paula Blazak, event coordinator for MainStreet Oceanside, said the festival has drawn about 30,000 attendees in past years, and expects the same amount this year.
The festivities will kick off Saturday with an evening production of "Ofrenda," a Spanish-language play put on by Cal State University San Marcos' multicultural students. The free play will be held in the Oceanside Public Library Community Rooms at 300 N. Coast Highway 101 and begins at 6 p.m.
After the performance, audience members will be able to participate in a candlelight procession to the Phantom Gallery, where they will view the work of photographer Tim O'Rielly, who is showing a selection of images he took at Dia de los Muertos celebrations in Oaxaca, Mexico. The gallery is located at 212 N. Coast Highway 101.
Sunday's festival runs from 10 a.m. to 4 p.m. and will feature live music, traditional Mexican fare such as Oaxacan tamales and pan de muerto and a children's craft area, where children can make skull masks and paper skeletons for 25 cents each.
One of the more unusual features of the festival will be its chalk altars. Festivalgoers will be given chalk, a vigil candle, several marigolds and a length of sidewalk where they can inscribe their own dedication to the dead. The altars are sponsored by San Diego Gas & Electric Co.
An educational presentation on the history and tradition of the holiday will be offered in English and Spanish at the Phantom gallery during Sunday's festivities. It will be led by Carlos Von Son, Ph.D., a professor of multicultural studies at Cal State San Marcos. The presentation will be held at 3 p.m. and 3:30 p.m. Call (760) 754-4512, or visit www.msoceanside.com.

subset: commoncrawl


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This weekend will mark the return of spring's Daylight Savings Time (DST). Beginning at 2 a.m. Sunday, March 10, Daylight Savings Time will return and all clocks should be moved forward one hour.
Senate bill 50 is now expected to make its way to the house floor for a vote, according to state Rep. Tom McKee.
Robert Meadows Jr., 45, was indicted Tuesday on charges of sexual abuse of a child less than 12 years old.
Head Harrison County Thorobreds Track Coach Robert Walker is not one to overstate his situation.
Monday morning when asked about all of the losses his team suffered from last year's regional champs, he simply said, "We did lose 16 athletes to either injuries or graduation, but we will represent the school in a good way. We lost some great runners, our whole mile relay team and a lot of speed but I believe in the athletes that are still here."
The Kentucky State Police Citizens' Academy that was scheduled to begin tonight has been moved to Thursday, March 14, at Maysville Community and Technical College-Licking Valley Campus in Cynthiana.
The classes will run for 11 weeks from 7-9 p.m. every Thursday with a graduation ceremony to be held on the 11th week.
Ten jury trials are scheduled for March 22 in Harrison Circuit Court.
Donald Silcox, who faces eight charges related to the sexual abuse of four children in northern Harrison County, was originally scheduled to stand trial on Jan. 24.
U.S. District Court Bankruptcy Judge Alan C. Stout signed two orders recently in the Brenda K. Brown case.
The judge ordered last week that Stewart Auction & Appraisal of Corbin, Ky., be paid $32,309 for its administrative expenses in the sale of Brown's Paintsville property.
I've always heard the term "old home week" and I just used it without really knowing for sure what it meant.
I am using it to mean seeing a lot of people that you know in one day in various venues, be it right or wrong.
Sunday was one of those days where I saw many people who are from Cynthiana or lived in Cynthiana in different places.
Alumni football coming back
for second year in April
Gridiron Alumni has announced that it will be coming back to Kentucky again this year for another series of exciting alumni football.
This year on Friday, April 5, the Harrison County alumni will again take on the Bourbon County Pride team. Game time will be released at a later date along with more information about the two teams.
The next night, the event travels to Montgomery County where the alumni from Montgomery County and Clark County will do battle.
Alvarez sentenced in 2012 shooting
A Cynthiana woman charged with shooting her husband last February is back in jail after her formal sentencing Tuesday morning.
Copyright © 2017
The Cynthiana Democrat is your source for local news, sports, events, and information in Cynthiana, KY and the surrounding area.


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Home Club Finder Balnagask Golf Course
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Dept 56 New England Benjamin Bowman Violin Maker NIB
Sold for:
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- Sold Date:
- Source: eBay
Up for bids is a NEW IN BOX DEPT 56 house BENJAMIN BOWMAN VIOLIN MAKER part of the New England Village series collection. Item number 56.56663 it consists of 1 porcelain house with cord. Introduced in 2002. Only removed from box for photo. Slight wear to corners of box but never used or displayed (stored away). Please email with any and all questions or additional photos. Happy Bidding!***PLEASE READ ALL TERMS BEFORE BIDDING*** SHIPPING: U.S BIDDERS ONLY. Discount shipping on auctions ending the same day. Delivery confirmation is included in shipping. Please use the shipping calculator for shipping charges. Not responsible if buyer chooses not to have insurance coverage for the item. PAYMENT: I accept PAYPAL ONLY . I will NO longer accept money orders/ checks (this has been abused in previous auctions). Item must be paid for within 3 days of auction end. NON PAYING BIDDERS: Do not bid if you do not AGREE with any of the above terms. Ebay will be contacted regarding non payers. FEEDBACK: Feedback will be posted once the buyer has posted feedback. If t is a problem please notify me prior to posting feedback. I cannot be held responsible for USPS handling once an item leaves my hands. NO REFUNDS/ EXCHANGES/ RETURNS, ALL ITEMS SOLD AS IS. I ATTEMPT TO DESCRIBE ALL ITEMS TO THE BEST ... read more


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XML/XHTML and CSS 2.1 renderer in pure Java. Welcome to Flying Saucer Flying Saucer takes XML or XHTML and applies CSS 2.1-compliant stylesheets to it, in …In this post, we will provide a basic example that explains how to convert a HTML document to a PDF file using the Java iText library. Converting a HTM file to PDF ...Grails is a high-productivity web framework based on the Groovy language that embraces the coding by convention paradigm, but is designed specifically for the Java ...Welcome to docx4j. docx4j is an open source (ASLv2) Java library for creating and manipulating Microsoft Open XML (Word docx, Powerpoint pptx, and Excel xlsx) files.About JTidy. JTidy is a Java port of HTML Tidy, a HTML syntax checker and pretty printer. Like its non-Java cousin, JTidy can be used as a tool for cleaning up ...x « Jar File Download ... java2s.com | Contact Us | Privacy Policy: Copyright 2009 - 12 Demo Source and Support.Java实现HTML转换PDF,飞子的网易博客,欢迎来到我的博客,不该茫然也茫然,心中无事心也烦。凡事终究有时尽,可我依旧心茫然。Flying Saucer is an XML/CSS renderer, which means it takes XML files as input, applies formatting and styling using CSS, and generates a rendered representation of ...For developers wondering about Microsoft's commitment to content controls, Office 2013 was certainly good news. In Microsoft's "What's new for Word 2013 ...11/19/2009 · Introduction This article specifies a simple Java code to convert any kind of files to a PDF using iText jar. First let me give a small intro about the ...
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The park has seen its share of history, ranging from visits by William Bartram, to scoundrels plotting the West Florida Rebellion, to rampaging Creek Indians and Confederate Troops screening the movements of Steele's Column in the closing days of the Civil War.
Some claim that history continues to play itself out from time to time on the park grounds. There have been reports of phantoms on the park grounds.
The most recent was last week, a volunteer claimed to see a shadowy figure wandering through the woods late in the afternoon. During an event several years ago, two different volunteers claimed to see the specter of a young man wearing colonial era clothing, wandering the woods with a lantern searching for something.
The most popular story at the park is connected to the old store and the phantom of an old man wearing overalls and a felt fedora. Several, including a park worker, claim to have seen this figure lurking on the front steps of the old store.
The specter is usually seen on dreary winter days in the late afternoon. Nicknamed "Sam," the phantom seems to have some connection to the old store and has been mainly observed loafing around the porch area.
Park officials downplay the ghost stories.
"I suspect the light may be playing tricks on their eyes," said Nick Warren, park director. "We definitely have a venue of rich history at the Park, but, I doubt we have any ghosts on the place."
"Of course if one wants to come face to face with a Baldwin County ghost, they should consider visiting the Haunted Trail hayride.
"This is our third year and we have added a number of new stops to the tour that include ghost stories from other parts of Alabama," Warren said. "We try and keep it scary but the hayride is more family oriented then many of the "in your face" events common to this type of genre."
Source: Baldwin County Now


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Energy Efficiency Directive (EED) excel spreadsheet finalised
An excel sheet comparing national implementation of the EED in 4 countries (BE-VL, DE, NL, UK) was presented to ETSA members in March. Following presentation of these results, members indicated they are now clear on requirements. There is no need for further compliance mapping for the moment. We thank Christeyns for their role in bring this data together.


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MIGUEL, TEXAS. Miguel (sometimes spelled Miguiel) is a farming and stock-raising community two miles northeast of the intersection of Farm roads 472 and 140 in far east central Frio County. A post office operated in the community from 1880 through 1924, though the office appears to have closed for a time around 1890. By 1884 Miguel had an estimated population of fifty. In 1906 it had two schools, with a total of two teachers and eighty-three students. The community of fifty had telephone service, three general stores, and a cotton gin by 1914. In 1929 it consisted of a church and a school surrounded by several dwellings. Miguel had a cemetery and two schools in 1948; one school was for nonwhite students. In 1989 the community still had a school and a cemetery.
BIBLIOGRAPHY:Mrs. W. A. Roberts, "Frio County Has a Colorful History," Frontier Times, June 1936.
Image Use Disclaimer
All copyrighted materials included within the Handbook of Texas Online are in accordance with Title 17 U.S.C. Section 107 related to Copyright and "Fair Use" for Non-Profit educational institutions, which permits the Texas State Historical Association (TSHA), to utilize copyrighted materials to further scholarship, education, and inform the public. The TSHA makes every effort to conform to the principles of fair use and to comply with copyright law.
For more information go to: http://www.law.cornell.edu/uscode/17/107.shtml
If you wish to use copyrighted material from this site for purposes of your own that go beyond fair use, you must obtain permission from the copyright owner.
The following, adapted from the Chicago Manual of Style, 15th edition, is the preferred citation for this article.Handbook of Texas Online, Ruben E. Ochoa, "Miguel, TX," accessed November 23, 2017, http://www.tshaonline.org/handbook/online/articles/hrmba.
Uploaded on June 15, 2010. Published by the Texas State Historical Association.
For more information about towns and counties including physical features, statistics, weather, maps and much more, visit the Town Database on TexasAlmanac.com!


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All In Beverage, LLC Selects Closure Systems International's Extra-Lok V 38mm OD Cap for Flagship Beverage
INDIANAPOLIS–(BUSINESS WIRE)–Closure Systems International (CSI) is pleased to announce that its Extra-Lok V 38mm OD cap has been selected for use on All In Beverage, LLC's portfolio of new age functional beverages. All In Beverage, LLC developed its flagship beverage brand, A-GAME, to fulfill the needs of next generation athletes and sports enthusiasts, and the company sought packaging to complement the brand.
A-GAME is an innovative, vitamin-fortified beverage that brings a spectrum of electrolytes, 8 essential vitamins, minerals, and carbohydrates. A-GAME has no artificial flavors or preservatives and contains 8 essential vitamins – C, D, E, B2, B3, B5, B6, and B12 – formulated to supply the body with the proper nutrition it needs to function properly on a day to day basis.
The key and distinct benefits of A-GAME include the use of honey for flavor and energy and the use of sea salt as a natural and highly effective alternative to replenish the body's water and electrolyte levels. Whether it is health conscious consumers, casual consumers, or sports enthusiasts, A-GAME is ideal for everyone. A-GAME is a vitamin enhanced premium beverage created to fulfill the need as the next generation of power refreshments.
A-GAME beverages are filled by Tampa Bay CoPack bottling company and are packaged in 20 ounce PET bottles by Graham Packaging. These packages are topped with CSI's versatile, light-weight Extra-Lok V 38mm OD caps. CSI's cap was chosen over alternative closure options due to its high performance sealing, safety features, premium aesthetics, and its application efficiency according to Kurt Reid, All In Beverage, LLC President.
"CSI's closure provided the look and functionality that we needed for our A-GAME packaging, and Tampa Bay CoPack appreciates that no steam is required for capping application. Packaging that satisfies the consumer and the bottler is always appreciated," said Reid.
About CSI
Closure Systems International, Inc. (CSI) is recognized as a global leader in closure design, manufacturing, and high speed application systems. In addition to quality closures and capping equipment, CSI provides unparalleled customer and technical services globally. Major categories served include carbonated soft drinks, bottled water, juices, isotonics, teas, adult beverages, dairy, foods, and automotive fluids.
CSI's closure systems solutions help customers maximize profits by increasing the marketability of their brands and optimizing their total cost of operations. In its 31 locations worldwide, CSI employs approximately 3,900 people. CSI is part of Reynolds Packaging Division, an operating division of the Rank Group. Visit CSI's website at www.csiclosures.com.
About All In Beverage, LLC
All In Beverage, LLC is a privately owned company based in Orlando, Florida that manufactures and distributes various flavors of vitamin enhanced premium beverages. Founded in August of 2010, the primary goal of All In Beverage, LLC is to penetrate the enhanced beverage market with a more refined new age concept using only all natural flavors including the benefits of honey for flavor and energy and sea salt as a natural and highly effective alternative to replenish the body's water and electrolyte levels.


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On March 12, the Department of Energy released its Wind Vision report, which takes stock of the current state of wind energy in the US and examines economic and environmental benefits from continued growth of wind power production. The report models different scenarios to examine the impact of increasing wind energy production, including a scenario (the "study scenario") in which production rises from current levels (4.5% of US annual electricity generation at the end of 2013) to 10% in 2020, 20% by 2030, and 35% by 2050. The report contains a number of findings that would support continued federal investment in wind power infrastructure and technology. The environmental benefits to be derived from increased reliance on wind power are remarkable. The report concludes that, by 2050, the projected increases in wind power production could:
- Offset 12.3 gigatonnes of greenhouse gases (wind power is already reducing these emissions);
- Offset 2.6 million metric tons of sulfur dioxide, 4.7 million metric tons of nitrogen oxides, and 0.5 million metric tons of fine particulate matter, which is equivalent to more than $100 billion in savings from avoided healthcare costs and economic damages; and
- Save 260 billion gallons of water that would otherwise be used by electric power plants.
The report also describes numerous economic benefits that would flow from increased use of wind power. The report concludes that the wind industry has the potential to support hundreds of thousands of jobs nationwide over the course of the study period. The report also concludes that wind power is quickly becoming competitive with fossil fuels and could ultimately become less expensive than fossil fuels. If wind power achieves the levels of penetration described in the study scenario, it would result in a modest increase in energy prices in the short term, which would be followed by greater savings in the longer term. The projected increases in wind power production also would make the electricity sector substantially less sensitive to changes in fossil fuel costs, and the resulting downward pressure on fossil fuel prices could generate large savings in natural gas prices through 2050. Local governments also can expect to benefit from increased deployment of wind power through added revenues from land lease payments and real property taxes.
Notably, the report shows the impact of the various expirations of the production tax credit. Historically, installation of wind power capacity has dropped sharply each time the credit has expired and rebounded following the subsequent extensions.


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The Master Designer Trailer (2014)
01 January 2014
With the advance of science we see life in intricate detail and mind-blowing wonder.How did this all come to be? Can it all be attributed to unintelligent random processes? Does the scientific evidence now demonstrate clear design and reveal a Master Designer? Join host Brian Corsetti on a journey into our created world to discover clues and answers that the animals themselves reveal. And discover the remarkable story of how some of these animals have even changed the course of history!
Watch the official The Master Designer 2014 trailer in HD below or find more The Master Designer videos on Vidimovie.


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Hey guys! I believe this is my first post in the critique section, but it's about time.
I'm trying to adopt a work process with this painting. I first doodle thumbnails on my sketchbook. When making these I have a general idea of whether they are for environment, illustration, or character use. If I see a good thumbnail, I either redraw it in more detail or bring it straight to photoshop. I then start building the composition with general values and shapes in mind. I flip the image horizontally to find flaws and vertically to check how my composition is holding up. I try to work in greyscale for as long as I can, then carefully add color mostly using the 'color' layer.
Here's a painting I started yesterday following this method. I feel it works quite well with the foreground dark, middleground with character medium and background lightest.
I notice I want to make the clouds behind the character super white to make sure the character is the focal point and pops out. But I feel this method is somewhat confining me and leaves me with no choice. What other way are there to make your focus pop out? Saturation and sharpness are a few, as well as composition of course. I also want to try to make a lighting effect similar to Panshi's entry on this ChOW. Frazetta seems to do this drastic lighting on his characters even more so.
Also how is the value scale on your screens? I'm working on a laptop and I wouldn't be too trusty with this thing. Looking at it now I could definitely increase the darker values on the bottom and on the character. What do you think?


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A driver lost control of a motor home after a front tire blew out, it rolled over, trapping a passenger underneath, killing her.
The Nebraska State Patrol reports 64-year-old Brenda Evans of Choctaw, Oklahoma died in the crash on U.S. Highway 83 near the village of Wellfleet in western Nebraska's Lincoln County.
According to NSP, Evans was trapped underneath the vehicle.
Also injured in the wreck were her husband, 65-year-old Ronald Evans, and her two teen-age grandchildren. All the injured have been hospitalized.


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Serve with Westwood
Join one of the many serving teams that bring our church to life each Sunday. It takes MANY people to create an environment which helps people LOVE GOD and REACH PEOPLE. We will help you match your abilities, passions and gifts to a place and team where you can thrive as you serve and love God's people. It is one of the best ways to get connected! If you aren't sure what area would be best for you, you might benefit from using our AssessMe resource to help you figure out where to serve. Please complete your spiritual giftedness and personality assessments.
Jodi Burbank at firstname.lastname@example.com


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At M. Cabrera & Associates, PC, we are determined to mount a successful defense to your foreclosure action. You can be confident that we will use every resource available to protect your home. Effective defenses to a foreclosure action include:
Failure to have proper documentation
. It is often difficult for the lender to prove that it actually owns the mortgage. If the original lender assigned your loan to another institution, the assignment may be improperly documented or legally insufficient. If the foreclosure complaint that was served on you did not have the proper documents attached, that's often a sign that the lender couldn't come up with the documents.
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You are in the military.
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Dec. 6 Meet
The meet on the 6th is at the Reynolds Pool from 3:30-6:30.
Please decide what your swimmer will swim this week. This MUST be submitted by 9pm Tuesday!!!
* Required
Swimmer's Name?
Emma America
Gabriel Askew
Grace Askew
Holly Buke
Ellie Choi
Shaylee Clapp
Olive Clapp
Madison Craft
Rowan Dooley
Madeleine Dutt
Caleb Farmer
Megan Farmer
Heath Frost
Ella Frost
Hannah Gitt
Lillian Golden
Christopher Gowens
Avery Guffee
Ella Guffee
Grant Hampton
Paige Hampton
Luke Hampton
Hannah Hilton
Annika Hilton
Emily Jaramillo
Ainsley Killian
Grady Killian
Sydney Leslie
Elisabeth Longacre
Lillian McFarland
Gwendalyn McFarland
Rachel Mittelstaedt
Mark Mittelstaedt
Ariel Otto
Garrett Parker
Anna Parks
Jacob Powers
Grace Powers
Jared Reynolds
Evan Reynolds
Seth Riche
Trinity Slocum
Haven Slocum
Maggie Suter
Maya Terhaar
Valerie Vreugdenhil
Katy Willis
Hailey Woody
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7th-8th (Cadet)
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Five Pieces from The Battell
By William Byrd
Trombone quartet - Grade 4
Composed by William Byrd (1540-1623). Arranged by Ray Horton. Published by Cimarron Music Press (BV.617).
Item Number: BV.617
The Souldier's Summons; The Marche of the Footman; The Marche of the Horsemen; The Irishe Marche; The Bagpipe and the Drone.


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Claire's Accessories (Shop)
100 reviews from the community
Review of "Claire's Accessories (Shop)"
A huge thanks for all the reads, rates and comments. It's much appreciated :)
"Beads, Bracelets, Bags & Belts!"
I first shopped in Claires Accessories whenI was about 12 (roughly). I used to spend my birthday money on sparkly nail varnish and stick on gems.Im 21, and I dont really shop here anymore. After working there for a few months, I began to actually realise how pricey things were.
So what do Claire's sell?
Claire's Accessories, sell's necklaces, bracelets, nail varnish, hair bands, hair clips, hair brushes, Earrings, Belts, Begs. Tiara's, wands, Hats, dressing up stuff & you can also et our ears pierced at many stores by a trained ear piercing specialist.
They sell a large range of different products for different ages. They sell hairbands, hair bobbles, Bracelets, Necklaces and more for the younger children under 12, and they also do a special range for teens. The rest is aimed at older people, which includes necklaces, bracelets, earrings, body jewellery and more! They also do Hen night items such as flashing badges and garters and also dressing up kits such as police-woman, bunny and a range of head pieces and masks.
The bracelets, Necklaces and other products tend to be blocked into colours in the claire stores, so if you know what colour item you want its fairly easy to find. They have a large range of colours ranging from Yellow, Blue, Red, Black, White, Green, Pink and more.Claires also do gift vouchers.
What are the claires stores like?
I've been to a few and experience of working in a claires store, they're not the most easiest store to keep tidy. At the tills they normally have offers, such as 3 for 2, which they will tell you about if you make a purchase. Staff are friendly and most should greet you on arrival & do the best they can to help you. How-ever when I've been in a few stores, i have never been approached or greeted by a member of staff.
I would agree with some of the prices of various things, such as a plastic bangle, would cost about £2.50, and a beaded necklace to match would maybe cost about £4.00. How-ever they do a range with diamante's in. This includes necklaces, Tiara's, earrings and bracelets. I think these are over-priced as they charge upto £6.50 for a single necklace and its the type of jewelley that'll turn a dull colour and leave a blue colour across your neck/wrist if you wear the item too much.
Ear Piercing
Staff are trained through ear piercing and only a qualified ear piercing specialist will pierce your ears. You get the choice to choose from a range of studs, which are avaliable in gold and silver-plated as well as others. Im not sure on the price of ear piercing but I found when I worked there it was very reasonable. With ear piercing, it also includes a bottle of cleaning solution and you can go back anytime with a certain period and get the specialist to check your ear piercings for you.
Some accessories in claire's are of reasonable price, but I prefer to go some-where like Accessorize as I feel claire's is a bit too young for me (I'm 21!). They do have very good sales at claires and these are woth checking out if you have any children's parties as you can normally get a large selection of things for party bags, etc. This is a great shop to get your hen-night badges, and other items from. I would recommend this shop to parents and to people who have children so their girls can spend their pocket money in there. I feel I could get better quality items for the same price in Accessorize, if I want something for a special occasion or to just glitz up an outfit!
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Comments on this review
danielclark691 published 09/05/2015very well reviewed
Deesrev published 19/02/2013Such a smashing well rounded review even noting the products for the different age ranges. I didn't realise 'Claires also do gift vouchers'. Really good to know. xXx
KateHurst published 24/05/2009I think this was a particularly well-balanced view since you had worked there at one time. What always worried me (being the needle-phobe that I am) was that they seem to do the piercings in a part of the shop quite close to the window where others can see but perhaps they don't do that in all shops? I especially liked your assessment of the target market Claire's is aiming to attract.
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Product Information : Claire's Accessories (Shop)
Manufacturer's product description
Listed on Ciao since: 11/08/2000


text: Video News: United Kingdom Mandela leaves hospital ROUGH CUT - NO REPORTER NARRATION Former South African president Nelson Mandela left hospital on Saturday after more than a week of treatment of pneumonia that raised global concern about the health of the 94-year-old anti-apartheid leader. Mandela was driven to his Johannesburg home in a military ambulance after doctors discharged him from Mediclinic Heart Hospital in Pretoria. The South African presidency said Mandela, who spent about 10 days in hospital, would receive further medical care at his residence. This was the third health scare in four months for the Nobel Peace Prize laureate, who became South Africa's first black president in 1994 and who is a global symbol of tolerance and the struggle for equality. © DailyMotion - Saturday, April 6, 2013


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Black & White 2 - Battle of the Gods
Title Data
- Genre:
- Strategy > Real-Time > General
- Developer:
- Lionhead Studios
- ESRB Descriptor(s):
- Blood and Gore, Crude Humor, Use of Alcohol, Violence
- Number of Players:
- 1 Player
- Wikipedia (EN):
- https://en.wikipedia.org/wiki/Black_%26_White_2
Release Data
Included in Compilation
Data and credits for this game contributed by stuwhyte and joneckersley.
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This is the best video I have ever come across that shows my favourite method for making mosaics. If you watch this from the beginning till the end you will appreciate why mosaic is expensive, hard to make and mostly why it requires an appropriate space where to cut, assemble and construct your mosaic piece. I really miss that grassello di calce.
A presto!
Mosaicology Blog


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H.R.1368 - Department of Defense Acquisition Management Reform Act of 1995104th Congress (1995-1996)
|Rep. Kasich, John R. [R-OH-12] (Introduced 03/30/1995)
|House - National Security; Government Reform
|Latest Action:
|House - 04/12/1995 Executive Comment Requested from DOD. (All Actions)
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- Armed Forces and National Security
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Related Bills (1)
Summary: H.R.1368 — 104th Congress (1995-1996)All Information (Except Text)
There is one summary for H.R.1368. Bill summaries are authored by CRS.
Shown Here:
Introduced in House (03/30/1995)
Title I: Performance Based Acquisition Process
Subtitle A: Performance Goals
Subtitle B: Results-Oriented Acquisition Process
Subtitle C: Rapid Contracting
Subtitle D: Performance Based Contract Management
Subtitle E: Financial Management
Subtitle F: Defense Acquisition Workforce
Subtitle G: Revision of Procurement Integrity
Subtitle H: Clerical Amendments
Title II: Reorganization and Reform of the Defense
Acquisition System
Subtitle A: Streamlining and Improvement of Acquisition
Subtitle B: Transfer of Functions
Subtitle C: Conforming Amendments
Subtitle D: Effective Date
Title III: Depot-Level Maintenance
Department of Defense Acquisition Management Reform Act of 1995 - Title I: Performance Based Acquisition Process - Subtitle A: Performance Goals - Amends Federal defense procurement provisions to: (1) require acquisition programs of the Department of Defense (DOD) for each DOD appropriation account to be assessed for achieving on average 90 percent of their cost, performance, and scheduling goals; and (2) direct the Secretary of Defense to terminate any major defense acquisition program that fails to meet at least 50 percent of its cost, performance, and schedule goals.
(Sec. 103) Amends the Federal Acquisition Streamlining Act of 1994 to direct the Secretary to include certain additional incentives such as pay and promotion incentives within a system which encourages excellence in the personnel management of defense acquisition programs (DAPs). Requires a review of such system to be completed by October 1, 1997, and requires a report from the Secretary to specified congressional committees.
Subtitle B: Results-Oriented Acquisition Process - Directs the Secretary to revise DOD regulations relating to the acquisition of major systems and information technology systems.
(Sec. 112) Directs the Secretary to define in appropriate regulations a simplified acquisition program cycle (cycle) that is results-oriented and consists of the following phases: (1) the integrated decision team meeting; (2) prototype development and testing; (3) product integration, development, and testing; and (4) production and integration into existing systems. Utilizes established maximum time limits for the completion of the cycle and each of its phases, with alternatives to such limits. Requires the acquisition program approval process to have one major decision point which shall occur before the program proceeds into product integration, development, and testing, directing the Under Secretary of Defense for Acquisition to review, and make certain determinations with respect to, such program. Requires any regulations adopted to ensure that potential users of an item being acquired under a cycle are afforded an opportunity to participate in the acquisition decisions during the appropriate phases.
(Sec. 113) Prohibits the Secretary from issuing a notice to proceed with production of a major system until: (1) at least one phase of initial operational test and evaluation has been completed, during both the prototype development and testing phase and again during the product integration, development, and testing phase; and (2) the Director of Operational Test and Evaluation has made certain certifications to the Secretary concerning testing and evaluation procedures and conditions. Authorizes the waiver of such requirements under certain conditions, including for national security reasons. Prohibits operational testing of a new system other than a major system until the head of the operational test and evaluation agency of the military department concerned determines the quantity of articles of the system that are to be procured for operational testing.
Repeals a Federal provision requiring any increase in the quantity of articles to be procured for low-rate initial production to be made only with the approval of the official making the original quantity determination. Prohibits such quantity from being increased by more than ten percent of the original quantity as of the date on which funds appropriated for procurement are first obligated for the program. Allows such original quantity to be exceeded in addition to the ten percent increase during periods of war or national emergency or when the Secretary makes certain certifications to specified congressional committees concerning the necessity of such action. Requires the Director of Operational Test and Evaluation to report directly to the Secretary (currently, the Secretary and the Deputy Secretary of Defense), without intervening review or approval.
(Sec. 114) Directs the Secretary to revise existing DOD directives regarding development and procurement of certain information systems in order to consolidate those directives into one series of directives that is consistent with the simplified cycle established under this Act.
Subtitle C: Rapid Contracting - Directs the Secretary to establish, and take necessary action to achieve, a goal of reducing by 50 percent the time necessary for DOD to acquire an item for the user of that item.
(Sec. 122) Authorizes a contracting officer of an agency receiving more than three competitive proposals for a proposed contract to solicit best and final offers from three of such offerors, without conducting discussions with representatives of all of the competitive offers.
(Sec. 123) Authorizes the Secretary to establish a contractor certification system for the procurement of DOD property or services that are acquired on a repetitive basis. Authorizes the head of a DOD agency to enter into such a contract on the basis of a competition among contractors certified under the system. Provides for the termination of such certification under appropriate circumstances.
(Sec. 124) Requires solicitations for defense contracts for the procurement of property of services to include a statement of past contractor performance of the offeror and any certification of the offeror under the certification system established under this Act. Directs the Secretary to maintain a contractor performance data base containing performance histories of each contractor under DOD contracts.
(Sec. 125) Requires (currently authorizes) the head of a defense agency to enter into multiyear contracts for the purchase of property whenever certain cost savings and other factors are present.
(Sec. 126) Directs the Secretary to authorize and encourage the use of leasing in the acquisition of equipment when practicable and otherwise authorized by law. Requires a report on legislative changes required to facilitate such leases.
Subtitle D: Performance Based Contract Management - Includes within unallowable defense contractor costs: (1) labor costs in excess of those provided in the contract offer; and (2) bid protest costs.
(Sec. 132) Directs the Secretary to prescribe in regulations: (1) policies and procedures that encourage DOD contract administrators to submit to program managers for consideration alternative approaches to contract management, including an analysis of the costs and benefits of each alternative; and (2) a clause, to be included in each cost- and incentive-type contract, that provides contractor rewards for exceeding the contract cost, schedule, or performance parameters, as well as contractor penalties for failing to adhere to such parameters.
Subtitle E: Financial Management - Requires the Secretary, before initial funding is made available for a phase of the acquisition program cycle for which an authorization of appropriations is specifically required, to submit to the Congress information concerning the objectives and plans for conducting such phase and the funding requirements for the entire phase. Directs the Congress, in authorizing appropriations for such a phase, to provide a single amount sufficient for carrying out the entire phase. Requires specific identification of the phase being funded.
(Sec. 142) Authorizes the Secretary to transfer funds from appropriations available for a particular acquisition program phase in order to pay the cost of incentives provided to program managers who have been certified by the Secretary as having achieved at least 90 percent of the cost, schedule, and performance goals established for that phase.
(Sec. 143) Directs the Comptroller General to review and report to the Congress on commercial practices regarding DOD accounts payable, and to develop standards to be used by the Secretary for improving DOD contract payment procedures and financial management systems. Empowers the Secretary with certain responsibilities with respect to corrective actions necessary to resolve weaknesses found by the Comptroller General.
Subtitle F: Defense Acquisition Workforce - Directs the Secretary to ensure that DOD management policies and procedures provide that education and training in acquisition matters, and past performance of acquisition responsibilities, are major factors in the selection of personnel for assignment to DOD acquisition positions. Requires demonstrated past performance of acquisition duties to be considered under various provisions relating to employee qualifications, requirements, and evaluations.
(Sec. 152) Directs the Secretary to provide for the acquisition of professional educational development and training services for the DOD acquisition workforce from commercial sources and through programs provided by Federal sources for all Federal acquisition personnel. Terminates provisions requiring the establishment and maintenance of a defense acquisition university structure. Requires DOD program managers and executive officers to have completed the course of development and training services established under this section. Authorizes the Secretary to submit to the Congress an alternative system of development and training.
Subtitle G: Revision of Procurement Integrity Requirements - Amends the Office of Federal Procurement Policy Act (the Act) to: (1) require the head of a procuring activity who approves a recusal request (request for dismissal from participation in a procurement contract due to possible conflict of interests) to retain such request for at least five years and make such request available to the public; and (2) make certain contract officer or employee certification requirements under such Act inapplicable to contracts of less than $500,000. Provides that no individual who, in the year prior to separation from service as a military officer in a covered position or an officer or employee of the Government, participated personally and substantially in acquisition functions related to a contract of $500,000 or more shall knowingly accept or continue employment with the contractor or subcontractor involved under such contract for a period of one year following separation from service, except for employment in an unrelated position. Defines a "covered position" as one which requires such officer or employee to work directly on contracts in excess of $500,000. Requires a procurement ethics training program for procurement officials who are likely to be involved in contracts, modifications, or extensions in excess of $25,000. (Currently, all officials must participate in the program.)
(Sec. 162) Provides penalties for those aiding, abetting, counseling, commanding, inducing, or procuring acts of Government officials which affect a personal interest of the individual.
(Sec. 163) Repeals certain superseded and obsolete laws.
(Sec. 164) Provides implementing regulations and requires Inspector General reports in each of FY 1996 through 1999 on compliance by the head of an agency in designating procurement positions covered by amendments to the Act.
Subtitle H: Clerical Amendments - Makes clerical amendments to Federal armed forces provisions, the Federal criminal code, and the Department of Energy Organization Act.
Title II: Reorganization and Reform of the Defense Acquisition System - Subtitle A: Streamlining and Improvement of Acquisition Management - Adds specified duties for the Under Secretary of Defense for Acquisition and Technology (Under Secretary).
Establishes in DOD a Defense Research, Development, and Acquisition Agency, with a Director and a Chief of Engineering and Analysis (Chief). Outlines the duties to be performed by the Agency, including the planning, programming, and carrying out of the research, development, and acquisition (RDA) activities of DOD, the preparation and integration of budgets for RDA activities, and the review of acquisition program plans. Provides for: (1) selection and evaluation of Agency program executive officers; (2) the organization of personnel; (3) policies and procedures for the interaction of commanders of unified and specified combatant commands with program executive officers regarding the initiation and conduct of weapons acquisition programs; and (4) the selection, evaluation, and duties of Agency program managers. Requires the Chief to be responsible for ensuring that all functional analytical capabilities provided to the Agency Director and its officers and managers in connection with DOD acquisition programs are the most advanced capability of their type. Limits the procurement authority of the Secretaries of the various military departments to that considered necessary for the sustainment of operations of that service branch.
(Sec. 202) Directs the Chairman of the Joint Chiefs of Staff to make recommendations to the Under Secretary regarding the desirability for joint development by the United States and one or more foreign countries of foreign products or systems.
Subtitle B: Transfer of Functions - Transfers, with specified exceptions, to the: (1) Secretary all RDA activities of the military departments; and (2) Agency all the functions of specified organizations and commands. Directs the Secretary to terminate all organizations whose functions are so transferred. Provides savings provisions.
Subtitle C: Conforming Amendments - Repeals specified Federal provisions concerning the general authorities and responsibilities of the defense acquisition workforce. Makes conforming amendments with respect to the transfer of certain RDA functions made earlier under this Act.
Subtitle D: Effective Date - Makes this title and its amendments effective one year after the date of enactment of this Act.
Title III: Depot-Level Maintenance - Repeals Federal provisions: (1) prohibiting more than 40 percent of funds made available for military department or defense agency depot-level maintenance and repair workloads from being used to contract for the performance of such workload by nongovernmental personnel; (2) prohibiting the management of DOD civilian depot-level maintenance personnel on the basis of end strengths; (3) providing an exception to (1), above; and (4) requiring a report concerning funds used to contract out for such work.
(Sec. 302) States that it is essential for the national defense that DOD preserve an organic maintenance and repair capability to meet readiness and sustainability requirements for the systems and equipment required for contingency plans. Requires the Secretary to identify those DOD maintenance and repair activities that are necessary to preserve such capability (core capability), and prohibits the Secretary from contracting out for their performance. Allows for the contracting out of non-core capability functions.
(Sec. 303) Directs the Secretary to provide for the performance by the private sector of all DOD depot-level maintenance and repair work except: (1) when no responsive bids for such performance are received from responsible offerors; or (2) for reasons of national security as determined by the Secretary.


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STARmeterSEE RANK
Down 45,371 this week
Rik Launspach
Rik Launspach was born on July 19, 1958 in Arnhem, Gelderland, Netherlands. He is an actor and writer, known for Manderlay (2005), Oeroeg (1993) and Het jaar van de opvolging (1998). He is married to Marjolein Beumer. See full bio »
Born:in Arnhem, Gelderland, Netherlands


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Asparagine–glycine–arginine–human tumour necrosis factor (NGR–hTNF) is a vascular targeting agent exploiting a tumour-homing peptide (NGR) that selectively binds to aminopeptidase N/CD13, overexpressed on tumour blood vessels. Significant preclinical synergy was shown between low doses of NGR-TNF and doxorubicin.
The primary aim of this phase I trial was to verify the safety of low-dose NGR–hTNF combined with doxorubicin in treating refractory/resistant solid tumours. Secondary objectives included pharmacokinetics (PKs), pharmacodynamics, and clinical activity. In all 15 patients received NGR–hTNF (0.2–0.4–0.8–1.6μgm−2) and doxorubicin (60–75mgm−2), both given intravenously every 3 weeks.
No dose-limiting toxicity occurred and the combination was well tolerated. Around two cases of neutropenic fevers, lasting 2 days, and two cases of cardiac ejection-fraction drops, one asymptomatic and the other symptomatic, were registered. Only 11% of the adverse events were related to NGR–hTNF and were short-lasting and mild-to-moderate in severity. There was no apparent PK interaction and the shedding of soluble TNF-receptors did not increase to 0.8μgm−2. One partial response (7%), at dose level 0.8μgm−2, and 10 stable diseases (66%), lasting for a median duration of 5.6 months, were observed.
NGR–hTNF plus doxorubicin was administered safely and showed promising activity in patients pre-treated with anthracyclines. The dose level of 0.8μgm−2 NGR–hTNF plus doxorubicin 75mgm−2 was selected for phase II development.
Tumour necrosis factor-alpha (TNF-α) was originally identified for its ability to induce apoptosis of tumour-associated endothelial cells and massive haemorrhagic necrosis of transplanted solid tumours (Carswell et al, 1975). Subsequent studies have shown that TNF-α can rapidly alter endothelial permeability and markedly decrease interstitial fluid pressure (Brett et al, 1989), both of which are believed to be critical for drug uptake in tumours. Disappointingly, early-stage clinical development using recombinant human TNF-α (hTNF-α) was hampered by severe systemic toxicity, the maximum tolerated dose being 10–50 times lower than the estimated effective dose (Creaven et al, 1989; Gamm et al, 1991).
To exploit a ligand-direct approach, asparagine–glycine–arginine–human tumour necrosis factor (NGR–hTNF) has been genetically engineered by coupling the N-terminus of hTNF-α with the C-terminus of a tumour-homing NGR-peptide, which is a ligand of the aminopeptidase N (CD13) overexpressed by endothelial cells of newly formed human tumour blood vessels (Curnis et al, 2000; Corti and Ponzoni, 2004). CD13 is a membrane-bound metalloprotease, and is thought to have an important role in chemokine processing and tumour invasion, and therefore is considered an attractive target for inhibiting angiogenesis. Recently, in a CD13-null mice model it was shown that although aminopeptidase-N activity is not essential for embryonic and foetal development, including de novo blood vessel formation (i.e., vasculogenesis) and normal adult function, it is crucial for the pathological development of new blood vessels from existing blood vessels (i.e., angiogenesis) in disease (Rangel et al, 2007).
In preclinical models, murine NGR–TNF showed a biphasic dose–response curve with significant anti-tumour activity even at very low doses in the nanogram range (0.005μgkg−1) (Curnis et al, 2002), equivalent in humans to a dose of 0.2μgm−2, which is the selected starting dose for phase I clinical development. Furthermore, it was shown that one mechanism underlying the synergism displayed by the combination between minute doses of murine NGR–TNF and doxorubicin was related to vascular barrier alteration and thus increased the uptake of this chemotherapeutic agent in tumours (Curnis et al, 2002). It is to be noted that NGR–TNF increased both the percentage of tumour cells that could be reached by doxorubicin in 2h and the intracellular amount of the drug, suggesting that NGR–TNF can alter drug-penetration barriers. Moreover, the sequence of drugs and the timing of administrations are crucial for these effects. In fact, the maximal synergism was observed within a 2-h interval between the administration of NGR–TNF and subsequent chemotherapy dosing in all models and with all chemotherapeutics tested (Sacchi et al, 2006).
Recently, the phase I dose-escalation study, exploring 17 dose levels ranging from 0.2 to 60μgm−2 in 70 patients, established the maximum tolerated dose (MTD) of NGR–hTNF at 45μgm−2, when given as a single agent once every 3 weeks, with dose-limiting toxicities at 60μgm−2 being characterised by grade 3 dyspnoea and acute infusion reaction (van Laarhoven et al, 2008).
In light of the promising preclinical findings, the present phase I clinical trial was designed to determine a safe low dose of NGR–hTNF in combination with the standard dose of doxorubicin.
The following inclusion criteria had to be met: age 18 years; histologically or cytologically confirmed solid tumour not amenable to any clinical improvement by current standard treatments; Eastern Cooperative Oncology Group (ECOG) performance status 1; normal bone marrow, hepatic, and renal function; previous treatment with a lifetime cumulative dose of anthracyclines <300mgm−2 (to allow the administration of an adequate number of cycles). Patients were excluded if they had significant cardiovascular disease, including a baseline cardiac ejection fraction (EF) <55%, or known central nervous system (CNS) metastases, as were patients who completed radiotherapy or systemic therapy within 4 weeks or underwent surgery within 2 weeks of the start of NGR–hTNF treatment. All patients provided written informed consent, and the protocol was approved by institutional ethics review committees.
This was a multicentre, multinational, phase I dose-escalation study with three patients who were administered each of four sequentially increasing low-dose levels of NGR–hTNF (0.2–0.4–0.8–1.6μgm−2), given intravenously through a 1-h infusion every 3 weeks, in combination with a fixed dose of doxorubicin (75mgm−2), given through a 15-min intravenous infusion, 2 h after the start of NGR–hTNF infusion. In the first cohort, NGR–hTNF was given at the starting dose of 0.2mgm−2 in combination with a lower dose (−20%) of doxorubicin (60mgm−2). The maximum cumulative dose of doxorubicin was capped at 550mgm−2. Patients with continued clinical response or stable disease were eligible to receive NGR–hTNF as a single agent until progressive disease or unacceptable toxicity.
The primary objective was to verify the safety of low doses of NGR–hTNF in combination with doxorubicin for the establishment of presence or absence of dose-limiting toxicities (DLTs). Secondary aims included a pharmacokinetic (PK) analysis of NGR–hTNF and doxorubicin, monitoring of soluble TNF receptor (sTNF-RI and sTNF-RII) levels, and preliminary anti-tumour activity assessment.
Dose-limiting toxicities applicable to the study were defined as adverse events occurring during the first cycle and fulfilling one of the following criteria: any grade 3–4 non-haematological toxicity, with the exclusion of alopecia, nausea, vomiting, and fever, which could be rapidly controlled with appropriate measures; an absolute neutrophil count (ANC) <500μl−1 lasting for 7 days; a neutropenic fever defined as ANC<1000μl−1 and fever>38.5°C; a thrombocytopenia 25000/μl or thrombocytopenic bleeding requiring transfusion; and a severe hypotension requiring dopamine administration.
A standard 3+3 escalation design was followed. At each dose level, the first patient had to complete one cycle before subsequent patients could be included. To increase the dose to the next dose level, the three patients enrolled at the previous dose level had to complete the first cycle. To fully document the safety profile, an expansion of the cohorts to six patients was planned the presence of one DLT. Intolerable dosage was defined as two or more out of six patients experiencing DLT and then the immediate lower dose level was considered as the maximum tolerated dose.
Pharmacokinetic blood sampling was carried out on day 1 with samples drawn before infusion and at 15, 30, 60, 90, and 120 (just before doxorubicin administration), 134 (1min before the end of doxorubicin administration), 180, 240, and 360min after the first three cycles. NGR–hTNF and soluble plasma TNF receptors (sTNF-RI and sTNF-RII) were computed by using an enzyme-linked immunosorbent assay and values obtained at different time points after each cycle were normalised by subtracting the time-zero value. The bioanalytical assay of doxorubicin and its metabolite doxorubicinol was carried out using liquid chromatography–tandem mass spectrometry. Maximum plasma concentration (Cmax) and area under the plasma concentration–time curve to the last detectable concentration (AUC0−t last) were estimated from plasma concentration–time data using the standard non-compartmental methods.
Tumour measurements were carried out at baseline and every 6 weeks until progressive disease. Measurable target lesions were evaluated for response using Response Evaluation Criteria in Solid Tumours (RECIST), and the duration of stable disease was measured from the start of therapy until the criteria for progression were met. Adverse events were recorded from day 1 till 28 days after the last dose, and were graded on the basis of the Common Terminology Criteria for Adverse Events (CTCAEs), version 3.0. Complete blood counts were assessed weekly while patients were on therapy. Assessment of left ventricular ejection fraction (LVEF) by echocardiogram was carried out before treatment and every other cycle. Doxorubicin was planned to be discontinued in patients who had experienced either a fall in LVEF from baseline 20% or a fall to 45%.
A total of 15 patients (5 women and 10 men), with a median age of 58 years (range, 31–82 years) and a performance status of 0 (60%) or 1 (40%), were enrolled between March 2006 and November 2006. All patients were heavily pre-treated: all had earlier received chemotherapy (median of two regimens; range, 1–6), including 60% (n=9) of the patients previously treated with an anthracycline-containing regimen, 86% before surgery, and 40% before radiotherapy.
In total, 89 cycles of NGR–hTNF (median, 6; range, 2–15) and 62 cycles of doxorubicin (median, 4; range, 2–8) were administered. According to the study protocol, six patients discontinued doxorubicin when they reached the maximum cumulative dose (i.e., 550mgm−2). All patients received at least one dose of study drugs and were assessable for toxicity.
No DLTs occurred and, as expected for this low-dose range of NGR–hTNF, MTD was not reached. Globally, treatment discontinuations were a result of progressive disease in 14 patients (93%) and an adverse event (pulmonary embolism) in 1 patient (7%).
The majority of haematological (29%) and non-haematological (71%) adverse events were mild (49%) to moderate (28%) in severity, with grade 3 and 4 being observed in 15% and 8%, respectively. The adverse events occurring in 20% of patients are listed in Table 1 and the incidence of grade 3–4 toxicities by dose levels and number of cycles is depicted in Figure 1.
The most commonly reported non-haematological adverse events were nausea, asthenia, pain, and vomiting, and these were mainly considered to be related to doxorubicin administration.
Haematological toxicity was assessed weekly throughout the study. In all eight patients (all treated with doxorubicin 75mgm−2) experienced grade 4 neutropenia in 17 cycles. However, neutropenia was generally short-lasting and reversible. There were only two neutropenic fever episodes, both occurring 2 weeks after the third cycle, lasting 2 days and recovering without sequelae. Three patients required haematopoietic growth factor support for neutropenia. A 20% dose reduction of doxorubicin was required in four patients for 10 cycles and a dose delay was registered in four patients for 7 cycles. No grade 4 anaemia or thrombocytopenia occurred.
All patients underwent LVEF assessment by echocardiogram every other cycle and the LVEF profile over time for all patients is illustrated in Figure 2. The EF values changed in only 2 of 15 patients assessed. An asymptomatic drop in LVEF from 50% to 40% was observed in an 83-year-old patient after the fourth cycle (lifetime cumulative doxorubicin dose of 500mgm−2), with a subsequent recovery to 60% recorded after two additional courses of NGR–hTNF monotherapy and following doxorubicin discontinuation. This patient, who was previously treated with liposomal doxorubicin, also experienced a grade 3 febrile neutropenia after the third cycle and was withdrawn from the study after the sixth cycle owing to progressive disease. An additional symptomatic drop in LVEF from 50% to 40% was registered in a 62-year-old male patient with small-cell lung cancer and with a positive history of hypertension and aortic aneurysm. He had been previously treated with doxorubicin. After the fourth cycle (lifetime cumulative doxorubicin dose of 400mgm−2), he had progressive disease and was hospitalised with a diagnosis of acute myocardial ischaemia. A coronarography revealed a thrombotic occlusion of the left coronary artery treated with angioplasty and stent placement. He was discharged after 3 weeks following an improvement of his clinical conditions. In both patients, neither anaemia nor other non-haematological toxicities of grade 3–4 were detected. Only 42 (11%) out of 390 adverse events were considered to be related to NGR–hTNF. All of these events were of mild (67%) to moderate (33%) intensity. About seven patients (grade 1, n=3; grade 2, n=4) experienced rigors/chills in 15 cycles, and three patients (grade 1, n=2; grade 2, n=1) experienced a transient blood pressure increase in 3 cycles. These events seemed to be dose unrelated to, short-lasting, and presented a clear temporal relationship between their onset and drug infusion, as they generally occurred about 30–40min after the start of infusion and lasted for approximately 30min.
The mean Cmax values of NGR–hTNF and AUC0−t last of doxorubicin during the first three cycles for each dose level are shown in Figures 3A and B. The average systemic exposure to NGR–hTNF during cycles 2 and 3 was comparable to that found during the first cycle and increased in a dose- and exposure-proportionate manner. The mean (±s.d.) NGR–hTNF Cmax achieved following the first cycle at doses of 0.2 (plus doxorubicin 60mgm−2), 0.2 (plus doxorubicin 75mgm−2), 0.4, 0.8, and 1.6μgm−2 was 2.22 (±0.58), 1.82 (±0.90), 4.44 (±1.70), 8.10 (±1.70), and 15.70 (±1.34)pgml−1, respectively.
The apparent terminal half-life (t1/2) of NGR–hTNF was relatively short, with means±s.d. ranging from 0.99±0.83h (dose level 0.2μgm−2) to 2.56±0.65h (dose level 0.8μgm−2). With the exception of slightly more prolonged t1/2 values reported in the present combination study, NGR–hTNF Pks were in reasonable agreement with those found in a low-dose, single-agent phase I study (Gallo-Stampino et al, 2007).
Consistently, doxorubicin systemic exposure was comparable among the five cohorts of patients who received the dose of 60 or 75mgm−2, irrespective of the NGR–hTNF dose given in combination, and between cycles 2 and 3 vs cycle 1. Overall, no apparent changes in the Pks of NGR–hTNF and doxorubicin were detected by administering the two drugs in combination.
During the first cycle of treatment at 0.2 and 0.4μgm−2, both the maximum (Emax) and the average (Eav) stimulatory effects attributed to NGR–hTNF on the plasma levels of sTNF-RI were scattered around 0, indicating neither stimulation nor inhibition effects of NGR–hTNF on the concentrations of the receptors. The levels of the receptor were slightly above 0 at 0.8μgm−2 dose, whereas an increase was observed only at 1.6mgm−2. For sTNF-RII a similar behaviour was noted. However, at the highest dose level tested (1.6mgm−2), the stimulation of the concentrations of sTNF-RII by NGR–hTNF was about two times higher than that of sTNF-RI (Figures 3C and D). Moreover, at this dose level Emax for both receptors was achieved around the time of attainment of NGR–hTNF maximal plasma concentration. No circulating antibodies to NGR–hTNF were detected.
One partial response was documented at the fourth dose level (NGR–hTNF 0.8μgm−2 + doxorubicin 75mgm−2) in a patient with oesophageal cancer and lung metastases, who was previously treated with two cisplatin- and fluorouracil-based regimens. An unconfirmed partial response was registered after the sixth cycle in an ovarian cancer patient who had previously received five chemotherapy regimens. Stable disease as the best response was reported in further 9 patients with a median duration of 5.6 months (Table 2). Off these patients with stable disease, the maximum changes in their target lesions ranged from 40% shrinkage to 9% growth (Figure 4A). Overall, the disease control rate (partial response + stable disease) in these patients who were resistant to standard chemotherapy, including 9 patients who were previously treated with an anthracycline-based regimen, was 73% (11 out of 15 patients). Median progression-free survival for the intent-to-treat patient population was 5.5 months, with some patients experiencing progression-free durations longer than those experienced while on the immediately previous regimen administered (Figure 4B).
In the present study, no dose-limiting toxicities were observed and the combination of low-dose NGR–hTNF with the standard-dose doxorubicin was safe and well tolerated, without an apparent exacerbation of the well-known toxicity profile associated to doxorubicin. In particular, NGR–hTNF did not appear to increase the frequency or severity of doxorubicin-related cardiac toxicity as measured by LVEF. Further analysis of this toxicity, however, would necessitate longer treatment durations in a larger patient population, monitoring of serial B-type natriuretic peptide and troponin levels, and the assessment of QT interval prolongation (Carver et al, 2007).
Moreover, only 11% of adverse events were considered to be related to NGR–hTNF, and it should be noted that these events were limited to manageable, short-lasting, and infusion time-related constitutional symptoms.
The combination of molecularly targeted agents with chemotherapy raises issues about the dose selection during early-stage clinical development. Indeed, some of the guideposts in combining chemotherapeutic agents (e.g., definition of MTD and avoidance of overlapping toxicities) might not be suitable when combined with biological agents that have low-toxicity profiles when used at the low-dose range. Moreover, given their mainly cytostatic nature, maximal anti-tumour activity could not necessarily coincide only with MTD, but also with lower drug dose, that is, the optimal biological dose (Kwak et al, 2007). Accordingly, the rationale of this phase I study was based on a preclinical model showing that even minute amounts of murine NGR–TNF were able to induce synergistic anti-tumour activity in combination with doxorubicin, mainly by damaging the tumour capillary network and increasing the chemotherapeutic drug uptake in the tumour (Curnis et al, 2002).
Although not directly measured in this study, the anti-vascular effects of NGR–hTNF have been previously observed by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the dose-escalation phase I trial (van Laarhoven et al, 2008) and in an additional single-agent phase I trial further exploring the low-dose range (Gallo-Stampino et al, 2007) and, therefore, could be considered supportive of the putative mechanism of synergism shown by NGR–hTNF and doxorubicin. However, the synergism of anti-vascular agents and chemotherapy could be alternatively attributable simply to targeting two distinct cell populations (Horsman and Siemann, 2006).
Notwithstanding the fact that optimal biological dose selection is challenging, it is interesting to note that the aforementioned low-dose single-agent phase I trial selected the dose of 0.8μgm−2 for further development, based on a more pronounced anti-vascular effect observed at this dose and the lack of shedding of soluble TNF-receptors registered up to this dose level. These soluble receptors can compete for TNF-α with the cell-surface receptors, thus blocking its bioavailability and activity, with the amount and speed of receptor shedding being linearly correlated with the serum TNF-α levels (Aderka et al, 1998). Similarly, no significant shedding of circulating TNF-α receptors was observed up to the dose of 0.8μgm−2 in this study. Furthermore, patients enrolled in this dose cohort experienced a low incidence of grade 3–4 toxicity and promising disease control.
Even though anti-tumour activity was not a primary end point of this study, the high disease control rate (73%) achieved in a population heavily pre-treated with chemotherapy, including 9 patients (60%) with an anthracycline-based regimen, seem to be promising by also taking into account the minimal toxicity profile associated to NGR–hTNF and the apparent absence of overlapping toxicity with doxorubicin.
In conclusion, the present phase I trial showed that the combination of low-dose NGR-hTNF and standard-dose doxorubicin is feasible, safe, and well tolerated when administered to patients heavily pre-treated with chemotherapy, including anthracyclines. The observed safety profile and anti-tumour activity warrant further phase II clinical exploration of NGR–hTNF 0.8μgm−2 and doxorubicin 75mgm−2 in anthracycline-sensitive solid tumours.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Natural Products
|The bark of Eucommia ulmoides
|Biological Activity or Inhibitors:
|1. Pinoresinol diglucoside is a putative α-glucosidase inhibiting compound.
2. Pinoresinol diglucoside is a important antihypertensive compound.
|Pyridine, Methanol, Ethanol, etc.
|Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:
|The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
|1 mg
|5 mg
|10 mg
|20 mg
|25 mg
|1 mM
|1.4648 mL
|7.3242 mL
|14.6484 mL
|29.2967 mL
|36.6209 mL
|5 mM
|0.293 mL
|1.4648 mL
|2.9297 mL
|5.8593 mL
|7.3242 mL
|10 mM
|0.1465 mL
|0.7324 mL
|1.4648 mL
|2.9297 mL
|3.6621 mL
|50 mM
|0.0293 mL
|0.1465 mL
|0.293 mL
|0.5859 mL
|0.7324 mL
|100 mM
|0.0146 mL
|0.0732 mL
|0.1465 mL
|0.293 mL
|0.3662 mL
|Citation [1]
Chem Biodivers. 2013 Jul;10(7):1322-7.
|Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents.[Pubmed: 23847077]
|The barks of Eucommia ulmoides (Eucommiae Cortex, Eucommiaceae) have been used as a traditional medicine in Korea, Japan, and China to treat hypertension, reinforce the muscles and bones, and recover the damaged liver and kidney functions. Among these traditional uses, to establish the recovery effects on the damaged organs on the basis of phytochemistry, the barks of E. ulmoides have been investigated to afford three known phenolic compounds, coniferaldehyde glucoside (1), bartsioside (2), and feretoside (3), which were found in the family Eucommiaceae for the first time. The compounds 1-3 were evaluated for their inducible activities on the heat shock factor 1 (HSF1), and heat shock proteins (HSPs) 27 and 70, along with four compounds, geniposide (4), geniposidic acid (5), Pinoresinol diglucoside (6), and liriodendrin (7), which were previously reported from E. ulmoides. Compounds 1-7 increased expression of HSF1 by a factor of 1.214, 1.144, 1.153, 1.114, 1.159, 1.041, and 1.167 at 3 μM, respectively. Coniferaldehyde glucoside (1) showed the most effective increase of HSF1 and induced successive expressions of HSP27 and HSP70 in a dose-dependent manner without cellular cytotoxicity, suggesting a possible application as a HSP inducer to act as cytoprotective agent.
|Citation [2]
Appl Microbiol Biotechnol. 2012 Feb;93(4):1475-83.
|Structure identification and fermentation characteristics of pinoresinol diglucoside produced by Phomopsis sp. isolated from Eucommia ulmoides Oliv.[Pubmed: 22048615]
|Pinoresinol diglucoside (PDG) is the important antihypertensive compound in Eucommia ulmoides Oliv., a traditional Chinese herb medicine. The research objective was to certify the possibility of producing PDG through fermentation. PDG-producing endophytic fungi were isolated from E. ulmoides Oliv., and the highest PDG-yielding (11.65 mg/L) isolate, XP-8, was identified as Phomopsis sp. according to the morphological characteristics and the phylogenetic tree constructed on the basis of the gene sequence in the internal transcribed spacers district. During the fermentation, PDG production outside cells starts at the later stage of cell growth when the residual sugar in the medium was low. The study reveals the possibility for production of PDG by fermentation.
|Citation [3]
Chem Pharm Bull (Tokyo). 2003 May;51(5):508-15.
|Biotransformation of pinoresinol diglucoside to mammalian lignans by human intestinal microflora, and isolation of Enterococcus faecalis strain PDG-1 responsible for the transformation of (+)-pinoresinol to (+)-lariciresinol.[Pubmed: 12736449]
|By anaerobic incubation of Pinoresinol diglucoside (1) from the bark of Eucommia ulmoides with a fecal suspension of humans, eleven metabolites were formed, and their structures were identified as (+)-pinoresinol (2), (+)-lariciresinol (3), 3'-demethyl-(+)-lariciresinol (4), (-)-secoisolariciresinol (5), (-)-3-(3", 4"-dihydroxybenzyl)-2-(4'-hydroxy-3'-methoxybenzyl)butane-1, 4-diol (6), 2-(3', 4'-dihydroxybenzyl)-3-(3", 4"-dihydroxybenzyl)butane-1, 4-diol (7), etc. by various spectroscopic means, including two dimensional (2D)-NMR, mass spectrometry and circular dichroism. A possible metabolic pathway was proposed on the basis of their structures and time course experiments monitored by thin-layer chromatography. Furthermore, a bacterial strain responsible for the transformation of (+)-pinoresinol to (+)-lariciresinol was isolated from a human fecal suspension and identified as Enterococcus faecalis strain PDG-1.


text:
A very Short Power Point Presentation by vee potter. EDTC 560 is a Web Design Class. We really studied hard. EDTC 560. To make our grades. We read our books. We studied our books and stretch our brains We've worked on Power Point We've struggled with Web Pages and made lots of gains.
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World high jump champ Williams struggles to qualify for Olympics
On a rainy Monday at the meet where the top three finishers typically book US Olympic berths, Williams slipped in with a fourth-place finish only because third-place finisher Nick Ross didn't make the Olympic A standard. "For me not to be on the team would be a disaster. It almost didn't happen for me," ," Williams said. "
Ross took three leaps at 2.31 metres, the height he needed to clear to qualify for the Olympics, but failed each time as Williams watched helplessly, unable to do more than hope his rival missed.
"I've never been in a situation quite that dramatic, wishing someone to miss," Williams said. "He had some really good jumps at 2.31. I was sitting there thinking, 'Miss them.' Normally I don't think that during competitions. Normally I don't put myself in that kind of distress."
Montano, who missed the podium at last year's worlds by .06 of a second, won the women's 800 in 1:59.08. Her season-best time of 1:57.37 at a Diamond League meet in Eugene on June 1 ranks second in the world this year. No American woman has won an 800 Olympic medal since Kim Gallagher in 1988. —


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Walker, J. 2009. Mining information-seeking behaviour data to enhance library services. This article was first published in Volume 22 Number 2 / 7 2009, of Serials: The Journal for the Serials Community
Lewis, N. 2008. Implementing Ex Libris's Primo at the University of East Anglia. This article was first published in Issue 55, April 2008, of Ariadne Web Magazine Read more
Sadeh, T. 2008. Multiple Dimensions of Search Results. Paper given at the Analogous Spaces Interdisciplinary Conference, Ghent University, Belgium, May 15-17, 2008 Read more
Sadeh, T. 2008. User experience in the library: a case study. New Library World: 109 (1/2). (Publisher)Read more
Sadeh, T. 2007. Transforming the Metasearch Concept into a Friendly User Experience. Internet Reference Services Quarterly: Special 2007 double issue on federated searching, Vol. 12, Issue 1 and 2.
Sadeh, T. 2007. User Experience for Library Users: Time for a Change.Password 01/2007 (printed version).
Sadeh, T. 2006. Google Scholar Versus Metasearch Systems High Energy Physics Libraries Webzine, issue 12, February 2006.
Koppel, Ted. 2006. Introduction to the Rapidly Changing World of ERM Standards.
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Exciting Developments in the [Imperial College London] Library! MetaLib – The New Library Portal. Impact (The Imperial College London Library Newsletter), Issue 6, Autumn 2005.
Sadeh, T. and Ellingsen, M. 2005. resource management systems: the need and the realization New Library World (2005, Vol.106, No.5/6) © Emerald Group Publishing Limited
Hiroyuki, I. 2005. Electronic Resource Management System (ERMS). The Journal of Information Science and Technology Association 55.6 (2005):271-275.
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Sadeh, T. 2004. To Google or Not to Google: Metasearch Design in the Quest for the Ideal User Experience. Paper given at ELAG 2004: Interoperability: new challenges and solutions, 28th Library systems seminar. Trondheim, Norway, June 9-11, 2004.
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Sadeh, T. 2004. The Challenge of Metasearching. New Library World, v. 105, no. 1198/1199, 2004, p. 104-112.
Tallent, E. 2004. Metasearching in Boston College--a case study of user reactions. New Library World, v.105, no. 1196/1197, p. 69-75.
Stubbings, R., and Hamblin, Y. 2004. How to make your e-resources earn their keep. Serials, 17(1), March 2004.
Sadeh, T. 2004. Developing an Electronic Resource Management System: Verde from Ex Libris, LIBER Quarterly, Volume 14 (2004), No. 3/4
Walker, Jenny. 2004. SFX. Marcel Dekker Encyclopedia of Library and Information Science, DOI: 10.1081/E-ELIS 120021368
Robertson, Wendy C., and Paul A. Soderdahl. 2004. Everything You Always Wanted to Know About SFX But Were Afraid to Ask. Serials Librarian 47 (1/2). Copyright 2004 by The Haworth Press, Inc., Birmingham, N.Y.
UK Serials Group P. Burnhill, L. Halliday, S. Rozenfeld, T. Kidd -SUNCAT: a modern serials union catalogue for the UK, The Journal for the Serials Community, 17(1), March 2004
Sadeh, T. 2003. Integrated Access to Hybrid Information Resources. LIBER Quarterly, v. 13, no. 1-4, 2003; p. 299-311.
Sadeh, T. and Walker, J. 2003. Library portals: toward the semantic Web. New Library World, v. 104, no. 1/2, 2003, p. 11-19.
Kaplan, Michael and Horn, 2003. Serial Aggregations-Multiple Versions and the Virtual Union Catalog: The California Digital Library, SUNY, and Ex Libris Experiences.
Walker, Jenny. 2003. OpenURL and SFX Linking. Serials Librarian 45(2003)3; p. 87-100. Copyright 2003 by The Haworth Press, Inc., Birmingham, N.Y. Available here by kind permission of The Serials Librarian and Haworth Press.
Translation to Catalan: OpenURL i l'enllacat SFX. Click here for local copy
Lagace, Nettie, 2003. The OpenURL and SFX Linking. Serials Librarian Vol. 44, no. 1/2, pp.: 77-89, 2003
Flynn, A. 2002. SuperSearching at UTS: Experience with a MetaLib/SFX installation. Paper given at VALA 2002: e-volving Information Futures, 11th Biennial Conference, February 6-8, 2002, Melbourne, Australia.
Gerrity, B., Lyman, T., and Tallent, E. 2002. Blurring services and resources: Boston College's implementation of MetaLib and SFX. Reference Services Review, v. 30, no. 3, 2002, p. 229-241.
Lewis, N. 2002. Talking about a revolution? First impressions of Ex Libris's MetaLib. Ariadne, 32, June-July 2002.
Lewis, N. 2002. Implementing Ex Libris's MetaLib portal at the University of East Anglia. Copyright UK Serials Group for publication in Serials journal 2003; used with permission for Ex Libris Web sites only. Talk given at Online Information 2002 (UK) December 3, 2002.
Stoklasov, B. and Krbec, P. 2002. Jednotn informaen brana CASLIN : projekt Narodn knihovny ER a Univerzity Karlovy. (Czech, original text).
Uniform Information Gateway: National Library of the CR and Charles University. (English version). Paper given at INFORUM 2002, 8th Conference on Professional Information Resources, May 21-23, 2002, University of Economics, Prague, Czech Republic.
Kaplan, Michael. 2002. Serial Aggregations-Multiple Versions and the Virtual Union Catalog: The Ex Libris Experience. Update of the Library of Congress paper presented at the IATUL conference 2002, 0n June 3 2002, in Kansas City MO.
Masuda, Yutaka, 2002. Linking in the scholarly information environment. Journal of Information Processing and Management Vol. 45 (2002) , No. 9
Masuda, Yutaka, 2002. OpenURL and SFX- Current Awareness. No. 274 (2002.12.20) CA1482 ISSN 0387-8007 Published by National Diet Library.
Walker, Jenny, 2002. SFX sets the Standard for Open Linking for Libraries. Library Hi-Tech News, Vol. 19 No. 4, May 2002
Walker, Jenny, 2002. CrossRef and SFX: complementary linking services for libraries. New Library World, Vol. 103 No. 1174, 2002
Sadeh, T. 2001. MetaLib and SFX: Managing Heterogeneous Resources in the Scholarly Environment.
Paper given at CASLIN 2001: Library of Academy of Sciences of Czech Republic and National Library of the Czech Republic, May 27-31, 2001, Beroun, Czech Republic.
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Walker, Jenny. 2001. Linking is as easy as SFX. UK Library Association Record 103, no. 12.
Walker, Jenny, 2001. SFX: Open Linking for Libraries. Library Hi-Tech News. Vol. 18, April 2001
Walker, Jenny 2001. SFX - the context-sensitive linking system for libraries. Serials. Vol. 14, No. 1, March 2001
Walker, Jenny, 2001. Open Linking for Libraries: the OpenURL framework. New Library World. Volume 102, Number 1163/1164, 2001
Van de Sompel, Herbert and Oren Beit-Arie. 2001. Generalizing the OpenURL Framework beyond References to Scholarly Works. The Bison-Fute Model. D-Lib Magazine 7, no. 7/8.
Van de Sompel, Herbert and Oren Beit-Arie. 2001. Open Linking in the Scholarly Information Environment Using the OpenURL Framework. D-Lib Magazine 7, no. 3.
Van de Sompel, Herbert, Thomas Krichel, Michael L. Nelson and others. 2000. The UPS prototype project: exploring the obstacles in creating a cross e-print archive end-user service. D-Lib Magazine 6, no. 2.
Kaplan, Michael . 2000. Exploring Parnerships: What Can Producers and Vendors Provide? Presented at the Library of Congress Bicentennial Conference on Bibliographic Control for the New Millennium: Confronting the Challenges of Networked Resources and the Web, on November 16, 2000, in Washington, D.C
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Amitai D. and Kaminer N., Ex Libris Ltd. 66th IFLA Conference Proceedings: Library Management Systems and the Statistical Requirements of Library and Information Managers
Van de Sompel, Herbert and Patrick Hochstenbach. 1999. Reference linking in a hybrid library environment. Part 1: frameworks for linking. D-Lib Magazine 5, no. 4.
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Van de Sompel, Herbert and Patrick Hochstenbach. 1999. Reference linking in a hybrid library environment. Part 3: Generalizing the SFX solution in the SFX@Ghent & SFX@LANL experiment. D-Lib Magazine 5, no. 10.


text: Our Silver & Gold Ornament Collection adds an elegant finishing touch to your holiday décor. Made from blown glass, our sets feature ball ornaments, teardrops, and finials in gold and silver with a variety of finishes—matte, shiny, and glittered. This collection is made to be mixed and matched for a festive Christmas tree that you can truly call your own.


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What most people don't know is that water pollutants can be assimilated by the human body in various ways. These pollutants can be very dangerous, as they can cause many health problems, especially for kids. Children who are exposed to certain water contaminants can experience delays in both physical and mental development, which can affect their entire life. Therefore, everyone should analyze their water reports, and based on the results, they should take the proper measures.
Drinking polluted tap water
Although your local authorities might claim that drinking tap water is safe, you should ask for reports that can help you find out what type of contaminants your water contains. Chlorine, lead, bacteria, chemicals and other impurities cam make people deal with memory loss, headaches and stomach disorders. Therefore, you must opt for buying an appliance that can help you eliminate all these risks. An effective water purifier can help you remove up to 99% of your water impurities, but you must make sure that you buy a product that can meet your needs. Therefore, we advise you to find out what type of impurities your tap water contains, and buy a whole house water filter that can remove the same type of impurities.
Is water purity important for cooking?
Using unfiltered tap water for cooking can also affect your health, because there are certain water pollutants that resist even to the highest temperature. So, if you imagined that consuming boiled water doesn't involve any risk, you were wrong. Moreover, using water that has a bad taste will also add a bad taste to your food, so making good coffee, tea and soups might not be as easy at seems. That means that you have to find the best water purifier that can cover up every faucet and fixture that your house has. A whole house unit can offer your clean water for all your needs, including for showering.
The importance of water quality when showering
Water contaminants can be absorbed through skin pores when showering, which can cause dry and irritated akin. Moreover, your eyes and hair can also be affected after coming in contact with impure water. According to many experts' opinion, water vapors can affect the quality of your indoor air, so you can also be exposed to breathing polluted air. However, all these risks can be eliminated by using a whole house water filter system to improve your home, so make sure that you take the right decision.


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Sandy Pollock, a graduate of the prestigious French Culinary Institute in New York City, derived the idea for the Casserole Queens during a holiday visit with her family. After making the Pollocks' signature dishes with her mom and siblings, she realized that everyone in the family was satisfied. She joined with her friend Crystal Cook to make traditional casseroles.
ME nAND MY DAYS WE 'LL HEAR THE CASSEROLE WAYS THE POLLACK OVER THERE BECAUSE WE 'RE HERE nBOTH WITHIN A COUPLE BACKGROUNDS WHO WAS IN nTHE FLESH ALSO A FOOD NETWORK RODEO BOBBY FLAY nWHAT IS FIRST OF ALL OF THOSE IN MARCH THEN YOU YOU AND HE nRICHARD ABOUT KELLY YOU nWERE IN THE AREA BRAVERY THAT WE nDOLE LOOKS AT nHOW ONE OF THE CASSEROLE QUEEN 'S ROOM OPERATION THREE YEARS NOW nNOW BE FAIR THE NOVEMBER THINGS GOING WELL THINGS ARE GOING WELL nI WANT TO SAY IT 'S A CATERING THING THAT nYOU CAN CALL THE WEEK BEFORE YOU GOT A MENU ONLINE BEGIN EVERYTHING AT VIRTUAL nAND nBASICALLY JUST GO ONLINE TO DEBBIE DEPUTY CASTLE QUEENS DOT COM YEAH THAT QUESTION nWE TAKE ORDERS IDEA TO DO OTHER THAN WE ALL SORT OF ACTIVITY nEASY FOR YOU TO DO YOU KNOW WHY WOULD WE HAVE TWENTY DIFFERENT CASSEROLE nSO WE HAVE A LOT OF A TRUE TO nPREPARE OUT ABOUT SIZE nHE THE IN THAT MAY BE A LITTLE SHORTER OTHER TH
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