text:
Because of the onslaught of new products, about 50% of European brands surpassed the US market's 14% sales increase in June. Porsche was the most impressive, with its sales more than doubling.
Its growth was fueled by a new, V-6 version of the Panamera four-door sedan. Meanwhile, Daimler AG increased 20% in June and 18% for the first half.
Mercedes-Benz rose by 25%, as helped by the year-old E-Class sedan and new E-Class coupe. Smart didn't do well at all, with sales of the ForTwo micro car falling 48% in June and 61% for the first half.
Volkswagen brand's sales rose by 11% in June and 30% for the first half, as its sales were boosted by the Golf hatchback and the Jetta SportWagen.
Audi's sales rose by 14% in June, matching the industry's gain and giving the brand a record 48,440 sales for the first half. Johan de Nysschen, president of Audi of America, said that he remained "optimistic" that Audi would set a US record for the year.
He said that what's holding Audi back at this point is not having enough of the cars in stock to sell. BMW of North America's 12% increase gain marked its biggest for the year.
But for the six-month period, it gained 6%. In a statement, Jim O'Donnell, president of BMW of North America, said that it expects sales to increase this month as it will offer the all-new 5 Series into the market.


text:
Brian Talcott is a partner in Dunn Carney's Litigation Practice Group. He is the firm's lead appellate attorney, and has briefed and argued numerous appeals in the state and federal appellate courts. Brian also specializes in insurance coverage, professional liability defense and complex civil litigation.
In 2009-2016, Oregon Super Lawyers recognized Brian as a Super Lawyer in Appellate Law. In 2014-2016, Brian was selected by his peers for inclusion in The Best Lawyers in America© in Appellate Law. Brian serves on the Board of Directors for Classroom Law Project.
Bar Admissions
- Oregon, 1996
- U.S. District Court District of Oregon, 1999
- U.S. Court of Appeals Ninth Circuit, 2000
- University of Oregon School of Law, J.D., 1996
Oregon Law Review, Managing Editor, 1995-1996
- University of California at San Diego, B.A., Political Science, 1991
Professional Associations
- Oregon State Bar,
Board of Bar Examiners, 2002-2005, Vice Chair 2004-2005
- Multnomah County Local Professional Responsibility Committee, 2007-2008
- Multnomah Bar Association
- Defense Research Institute
- Oregon Association of Defense Counsel
Board of Directors, 2008-2010
- Classroom Law Project, Board of Directors, 2012-present
Published Works and Presentations
- Medical Expenses (Co-author), 1 Damages Ch. 7, Oregon State Bar CLE, 1998 & Supp. 2002
- Trial Motions (Co-author), 2 Civil Litigation Manual Ch. 24, Oregon State Bar CLE, 2009
- Overview and Scope of Discovery (Co-Author), Federal Civil Litigation in Oregon Ch. 14, Oregon State Bar CLE, 2009
- Comprehensive Personal Liability Coverage (Co-author), 2 Insurance Ch. 28 Supp., Oregon State Bar CLE, 2003
- Overview of Oregon's Law for Insurance Agents/Brokers' and Agents and Brokers Errors & Omissions Insurance Coverage, Independent Agents and Brokers of Oregon (IIABO)
rated by Super Lawyers

subset: commoncrawl


text:
BP's Targetneutral fails to attract interest
Only 5,000 motorists offset their emissions through BP's much-publicised Targetneutral scheme in its first year. The scheme's advisory board is "actively considering" making it free to join.
Sorry you do not have access to this article. Please contact Customer Support at
or call 020 8267 8120


text:
Samantha Gown
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For more information about our Samantha Gown, please contact us by using the form below or by emailing us - firstname.lastname@example.com - or one of our stockists.


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Washington, DC (PressExposure) May 10, 2012 -- St. Johns, Antigua - Online Bingo just got more exciting with British based BingoBoat.com. The online bingo hall is extending their monthly bingo special this month like an Under the Big Top special. With generous deposit specials for new and returning members, the Bingo Boat is the new place for online bingo fun.
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text: My aunt just called and told me today she found out she has high blood pressure and high cholesterol. She put the Med Diet book on order. Does anyone have it or has used it? Recipes good? Can you post some (paraphrased) here and the premise of the diet so she can get started please?


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Get the Best Priced Volkswagen 411 Fuel Filter
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Philadelphia demands a lot from their sports teams. Expectations are always high. After a long rebuild, the Philadelphia 76ers are beginning to take shape as a legitimate future playoff
Tag: Wells Fargo Center
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Oral cancer is a significant health problem in the USA and throughout the world. Most oral cancer patients are diagnosed at a late stage, when treatment is less successful and treatment-associated morbidity is more severe. A number of new diagnostic aids to conventional oral examination have recently been introduced to assist in the early detection of oral neoplasia. In particular, autofluorescence imaging has emerged as a promising adjunctive technique to improve early identification of oral premalignant lesions. Direct visual inspection of tissue autofluorescence has shown encouraging results in high-prevalence populations, but the technique requires subjective interpretation and depends on the visual recognition skills of the examiner. Capturing and analyzing digital fluorescence images can reduce subjectivity and potentially improve sensitivity of detection of precancerous changes. Recent studies of wide-field autofluorescence imaging in low-prevalence populations suggest that benign lesions such as inflammation may give rise to false-positive results. High-resolution fluorescence imaging is a new modality that can be used in conjunction with wide-field imaging to improve specificity by imaging subcellular detail of neoplastic tissues. The combination of wide-field and high-resolution fluorescence imaging systems with automated image analysis should be investigated to maximize overall diagnostic performance for early detection of oral neoplasia.
Oral cancer is the eighth most common cancer worldwide, with approximately 274,000 new cases reported annually [1]. In the USA alone, it was estimated that 35,000 new cases were reported in 2009, and 7600 deaths were expected [2]. The majority of patients diagnosed with oral cancer live in developing countries [3]. In India, for example, oral cancer ranks number one in prevalence among all cancers in male patients and number three among cancers in female patients. In south central Asia, oral cancer ranks among the three most common types of cancer. Recent epidemiologic data show sharp increases in the incidence of oral cancer reported in European countries and, to a lesser extent, the USA [4].
Oral cancer survival rates are strongly dependent on the stage at diagnosis. Patients diagnosed with oral cancer at a localized stage have a substantially greater chance of successful treatment and less treatment-associated morbidity [2] than those diagnosed at a late stage. Improving early detection represents one of the best ways to improve survival and quality of life for oral cancer patients worldwide. In the USA, there has been only marginal improvement in the relative 5-year survival rates for oral cancer since 1975. The modest improvement in survival is due to a combination of earlier diagnosis and improved treatment [4]. In developing countries, oral cancer patients tend to be diagnosed at a later stage than in developed countries [5]. Thus, there remains an important need to improve early detection of oral cancer and its precursors.
The current goal of the International Agency for Research on Cancer, American Cancer Society and the WHO is to reduce the predicted 15 million cancer cases by a third by diagnosing and treating these cancers at their pre-neoplastic levels. Oral cancer is an ideal choice for this strategy because the oral cavity provides easy access for clinical inspection, and oral cancer development is preceded by visible mucosal changes [6]. However, only 40% of oral cancers are currently diagnosed as localized disease, which is the same rate as that of colon cancers [6].
Despite recent diagnostic and therapeutic advances, the 5-year survival rate for oral cancer has remained less than 50% over the last 50 years owing to the following reasons:
The 5-year recurrence-free survival rate is 80% for stage I oral cancer patients, whereas only 20% of patients with stage IV oral cancer survive after 5 years [7–9]. Moreover, early diagnosis of oral cancer significantly reduces treatment-related morbidity and improve overall long-term survival [10,11]. Patients with a history of oral cancers are at risk of developing second primary tumors at a rate of 3.7% per year because of 'field cancerization', and a quarter of all oral cancer-related deaths are caused by second primary tumors [12]. Hence, patients who are successfully treated for oral cancer should be closely monitored, preferably using a noninvasive diagnostic test.
Diagnosis of oral cancer at an early stage or at the pre-neoplastic level is critical to improve survival in oral squamous cell carcinoma patients. However, screening via clinical examination alone by general dentists during the patients' routine dental examination has resulted in poor detection rates. Dentists frequently detect white or red patches during routine screening of an asymptomatic patient. Based on analysis of biopsies of potentially malignant oral mucosal lesions (n = 926) submitted to an UT-Dental Branch Houston oral pathology biopsy service in 2009, more than 75% of these lesions are confounding lesions, which will be microscopically diagnosed as benign, except for a small proportion (<25%) being diagnosed as oral cancer or its precursor.
General dental practitioners do not have the clinical training and experience to distinguish potentially malignant lesions from confounding lesions; hence, many of these patients need to be referred to a specialist clinic for scalpel biopsy for a definitive diagnosis.
Referring patients with potentially malignant oral lesions to specialist centers is plagued by a long waiting time leading to significant diagnostic delays [13]. A recent study conducted in the USA reported that the mean time from the initial detection of a potentially malignant lesion by a primary healthcare provider and referral to a specialist for evaluation was 35.9 days [14]. In some cases, this delay exceeded 10 months [14]. For patients with newly diagnosed oral cancer, the median delay in initial diagnosis in Canada was 4.5 weeks, which is significantly shorter than in the USA, which is reported to be 18.4 weeks [14,15]. This longer delay is attributed to the disparity in healthcare systems and health insurance-related issues in the USA [14]. It should be noted that for patients with oral cancer, delays in diagnosis by even 1 month may contribute to a diagnosis of a later stage disease [16]. Moreover, treatment delays of more than 40 days in early-stage oral cancer were associated with an increased risk of locoregional failure impacting their survival [17]. In addition, scalpel biopsy is time consuming, uncomfortable and stressful for the patient and is a relatively expensive procedure.
Therefore, developing and validating an acceptable noninvasive diagnostic test that can discriminate benign oral mucosal lesions from oral cancers and its precursors with minimal false-positive and false-negative results would be beneficial not only for the patient but also to society by reducing heathcare costs through avoiding unnecessary scalpel biopsies.
The standard method for oral cancer screening has long been conventional oral examination and palpation, usually performed by dentists or physicians. Visual inspection of the oral cavity is performed under normal white light illumination, followed by palpation of suspicious lesions. Downer et al. has systematically reviewed the performance of visual examination for oral cancer detection [18]. Across the eight studies reviewed by Downer et al., sensitivity values ranged from 60 to 97% and specificity values from 75 to 99% [18]. Oral cancer specialists can often recognize subtle visual changes associated with early lesions, but community practitioners or general dentists may lack the experience to identify early lesion development.
Several visualization adjuncts to standard oral examination are now commercially available. Toluidine blue is a vital dye that has been used in the oral cavity for decades to improve the visibility of lesions during visual exam. In a recent review of the performance of visual exam with toluidine blue, sensitivity ranged from 38 to 98%, while specificity varied from 9 to 93% [19]. In general, examination with toluidine blue is associated with low specificity, and this has prevented toluidine blue from becoming a standard component of early oral cancer detection efforts in the USA.
The ViziLite® (Zila Pharmaceuticals, Inc., AZ, USA) system offers an alternative to white light illumination for visual examination; a disposable chemiluminescent light source illuminates tissue with blue light. Providers view reflected blue light to detect abnormal changes in oral cavity. Initial studies conducted by Epstein et al. [20] and Kerr et al. [21] indicated that the ViziLite could potentially aid in the detection of oral premalignant lesions by improving brightness and sharpness. Epstein et al. examined 134 patients who had identified oral lesions using conventional white light and ViziLite illumination [20]. The study showed that two lesions became clinically visible only after ViziLite examination. Kerr et al. examined 501 patients who had a positive tobacco history using conventional white light, followed by ViziLite illumination [21]. The study reported that six lesions not previously seen by conventional examination were identified by ViziLite examination. However, other studies have reported that the ViziLite does not aid in the identification of oral lesions [22–24]. In a study conducted by Ram and Siar, 40 patients in a high prevalence population were examined with the ViziLite, following conventional examination of the oral cavity [22]. Farah and McCullough examined 55 patients referred for assessment of an oral white lesion with the ViziLite, following conventional oral examination [23]. Both studies concluded that examination with the ViziLite did not change the diagnosis. The authors noted that ViziLite examination could not discriminate between benign or inflammatory and premalignant or malignant oral lesions. In a study conducted by Oh and Laskin [24], 100 patients who presented for dental screening were examined with the ViziLite, following conventional examination. Results demonstrated that all of the lesions were detected during standard oral examination, and no additional lesions were detected by the ViziLite. Thus, there remains an important need for alternative diagnostic methods that can enhance the visualization of oral lesions and particularly help discriminate benign and premalignant lesions.
In the previously described approaches, clinicians illuminate tissue with white or blue light and observe light that is reflected from the mucosal surface. However, there are a range of light–tissue interactions that can be exploited to improve the visualization of neoplastic lesions. In particular, tissue autofluorescence has recently shown promise as an adjunctive diagnostic tool. Fluorophores within the oral epithelium and stroma absorb UV and visible light and can re-emit some of this light at longer wavelengths in the form of fluorescence. When the reflected illumination light is blocked with an absorbing filter, it is possible to visualize the longer wavelength fluorescence even with the naked eye. Autofluorescence originates from a variety of fluorophores in the oral cavity, and is sensitive to alterations in both tissue morphology and biochemistry associated with neoplasia [25,26]. Oral cancer and precancer display a loss of autofluorescence across a broad range of UV and visible excitation wavelengths; as described later, this loss of fluorescence is largely attributed to a decrease in fluorescent crosslinks associated with stromal collagen that underlies the neoplastic lesion. The VELscope® (LED Dental, Inc., White Rock, BC, Canada) is a commercially available device to visualize tissue autofluorescence in the oral cavity. The VELscope has been approved by the US FDA as an adjunct to traditional oral examination to enhance the visualization of oral mucosal abnormalities, and its clinical use appears to be growing. Lane et al. described an initial version of this device for the direct visualization of oral cavity tissue fluorescence [27]. Visual identification of oral neoplastic lesions using the VELscope is based on the premise that abnormal tissue appears dark brown to black owing to decreased levels of autofluorescence, while normal healthy tissue emits pale green autofluorescence (Figure 1). The device achieved a sensitivity of 98% and specificity of 100% using histology as the 'gold standard' when discriminating normal mucosa from severe dysplasia/carcinoma in situ or invasive carcinoma in 50 biopsy sites from 44 patients. Two case study reports suggested that the VELscope can assist clinicians in detecting oral lesions that are occult under white light examination and in more effectively identifying which regions to biopsy [28,29].
A number of recent studies have suggested that the VELscope can be used as an adjunct to visual examination to improve the detection of oral neoplasia [30–35]. For example, Paulis suggests that the VELscope provides dental professionals with guidance in detecting oral cancer, noting that while it may provide some false-positive findings, it is a screening device not a definitive diagnostic tool [36]. However, although promising results have been reported, most of these studies have been limited to small numbers of patients in high-prevalence populations; several recent reviews [19,37–43] have highlighted the need for additional research to evaluate VELscope performance in general practice. Balevi noted that the potential for false positives may cause unnecessary stress and fear among patients, and increase morbidity and costs for patients when it is used in general practice as a routine screening tool [44].
A recent study reporting VELscope performance in a low-prevalence population highlighted this need. Huber examined 130 subjects who smoked at least one packet of cigarettes per day with the VELscope, following conventional oral examination [45]. The author found that ten suspicious lesions were detected by conventional examination, and no occult lesions were identified by the VELscope. Moreover, 72% (80 out of 111) of lesions or conditions clinically characterized as inflammation, ulceration or pigmentation demonstrated a loss of fluorescence on VELscope examination, potentially making it difficult to distinguish them from neoplastic lesions, which also exhibit decreased autofluorescence (Figure 2). The author concluded that the VELscope may be a useful adjunct for experienced practitioners, especially to monitor recognized lesions, but questioned its value as a general screening adjunct.
In a recently published study, Mehrotra et al. examined the diagnostic accuracy of the ViziLite Plus and VELscope in detecting oral dysplasia and carcinomas in 256 oral mucosal lesions deemed to be clinically innocuous based on conventional white light oral examination by an expert clinician [46]. The authors determined the specificity and sensitivity of the ViziLite Plus and VELscope in detecting oral dysplasia and carcinomas by comparing their respective finding with the gold standard scalpel biopsy results. They reported a disappointing 0% sensitivity and 75.5% specificity for the ViziLite Plus and 50% sensitivity and 38.9% specificity for the VELscope. The use of toluidine blue has been assessed as an adjunct to determine resection margins for oral cancer. In a case study of a patient with oral squamous cell carcinoma conducted by Missmann et al., small suspect lesions away from the main tumor were detected upon toluidine blue staining, and the resection area was enlarged to include these areas [47]. Resulting margins were clear, and the patient was disease-free for more than 3 years with follow-up. Kerawala et al. examined 14 oral squamous cell carcinomas from 11 patients to preoperatively determine resection margins with toluidine blue [48]. Invasive carcinoma stained with toluidine blue, which enabled complete removal in all cases. However, dysplasia or carcinoma in situ, which did not stain with toluidine blue, was identified in the margin of eight of the 14 samples (57%). The authors suggest that toluidine blue staining may be of value in identifying invasive cancers at margins, but may be of little value in delineating positive margins of dysplasia or carcinoma in situ and may not reduce incidence of local recurrences.
Direct visualization of loss of fluorescence also has potential to identify high-risk fields of precancer and cancer in order to better delineate surgical margins of oral cancer. Poh et al. showed that VELscope imaging could identify oral neoplasia in the operating room setting with a sensitivity of 97% and specificity of 94% in a study of 122 oral mucosa biopsies from 20 patients [49]. Poh et al. recently examined the rate of recurrence for oral cancer patients whose lesions were resected with standard visual guidance versus autofluorescence image guidance [50]. With a minimum 12-month follow-up, 32% of the 22 control-group patients experienced recurrence, while none of the 38 fluorescence-guided patients experienced recurrence.
The VELscope relies on the ability of the examiner to recognize loss of fluorescence, and performance depends on subjective visual recognition skills. As an alternative, digital images of tissue fluorescence can be captured and analyzed using quantitative image interpretation methods. To test this approach, Roblyer et al. developed a multispectral digital microscope, capable of collecting narrow-band reflectance and fluorescence images at a variety of illumination and emission conditions [26]. Roblyer et al. used the multispectral digital microscope to select optimal wavelengths to distinguish neoplastic from non-neoplastic oral mucosa [51]. Results showed that the normalized red-to-green fluorescence intensity ratio at 405 nm excitation provided the best discrimination between neoplastic and non-neoplastic areas. A quantitative algorithm, based on the red-to-green fluorescence intensity ratio from regions of interest, could discriminate normal tissue from dysplasia and cancer in a high-prevalence population, with a sensitivity of 95.9% and specificity of 96.2% in a training set of 46 subjects, and with a sensitivity of 100% and specificity of 91.4% in a validation set of 21 subjects.
This same approach was used to analyze the signal from each pixel in a fluorescence image to create a disease-probability map, indicating the likelihood that tissue underlying each pixel in the image contained neoplasia. Figure 3 shows an example of such a disease-probability map, superimposed atop a white light image. As shown in Figure 3, the results of the disease-probability map agree with histology. This type of image analysis approach may provide a more objective way to detect and delineate oral neoplasia in primary healthcare settings.
Recent studies have characterized the biochemical and micro-anatomic origins of tissue fluorescence, as well as how tissue autofluorescence changes with neoplastic progression. The autofluorescence properties of oral tissues vary based on anatomic site and pathologic diagnosis [52–54]. In normal squamous oral mucosa, autofluorescence in the UV and visible region of the spectrum is predominantly associated with collagen in the stroma. The epithelium shows weak autofluorescence, primarily associated with mitochondrial NADH and FAD in basal epithelial cells based on studies with MitoTracker® (Molecular Probes, Inc., OR, USA) and mitochondrial poisons. In addition, superficial keratin contributes to epithelial fluorescence. Neoplasia is associated with a strong loss of stromal autofluorescence, which is likely to be responsible for the loss of autofluorescence observed in wide-field images. In addition, epithelial dysplasia is associated with increased mitochondrial fluorescence throughout the epithelium. Inflammatory lesions are associated with a loss of both epithelial and stromal autofluorescence (Figure 4). Thus, wide-field fluorescence imaging, a technique that captures autofluorescence generated primarily in the stroma, may give rise to a loss of fluorescence in both benign and precancerous lesions. One approach to improve diagnostic accuracy is to obtain images from more superficial layers using high-resolution imaging systems.
An advantage of optical imaging of oral tissue is the ability to record images with subcellular resolution in vivo without performing biopsies. Several high-resolution imaging approaches have advanced to preclinical and clinical trials. Confocal reflectance microscopy is an optical technology that can provide detailed images of tissue architecture and cellular morphology throughout the epithelium of living tissue in near real time. Contrast is based on differences in refractive index, which can be enhanced using simple contrast agents such as acetic acid [55,56]. A miniaturized fiber optic confocal reflectance microscope has been developed to image oral neoplasia in vivo [57]. Distinct features indicative of oral precancer, such as nuclear enlargement, crowding and pleomorphism can be imaged and correlated well with histologic features observed in subsequent biopsies, as shown in Figure 5A.
Alternatively, fluorescent dyes can be applied to enhance image contrast and imaged using confocal fluorescence microscopy. Thong et al. investigated the capability of a confocal fluorescence microscope system to identify morphologic details in living tongue tissue [58]. Morphologic differences between normal and neoplastic lesions in tongue were distinguished using fluorescein and 5-aminolevulinic acid -induced protoporphyrin IX fluorescence. Recently, a pilot study of a confocal fluorescence microendoscope was performed to investigate the feasibility of high-resolution optical imaging for detection of oral neoplasia [59]. Confocal images obtained with exogenous contrast agents (topical acriflavine and intravenous fluorescein) showed architectural details of tissues, such as changes in nuclear size and spacing, and changes in capillary networks, providing the potential to distinguish carcinoma from normal mucosa as shown in Figure 5B. A fiber optic high-resolution fluorescence microendoscope was developed to visualize subcellular detail in living tissue [60]. The portable system uses light-emitting diode illumination to excite and collect fluorescence through a fiber bundle with no requirement for complex scanning mechanisms. Following topical application of proflavine, a surgically resected tissue specimen from the human oral cavity was imaged across the clinical margin, demonstrating qualitative and quantitative differences between normal and cancerous tissue based on subcellular image features such as nuclear-to-cytoplasmic (N/C) ratio, as shown in Figure 5C.
Carlson et al. developed a dual-mode reflectance and fluorescence confocal microscope (DCM) to image molecular properties of tissue as well as tissue architecture and cellular morphology using reflective and fluorescent molecular-specific contrast agents [61]. Images obtained with the combination of reflectance and fluorescence provide information about both the morphologic and molecular changes associated with cancer progression. A total of 33 biopsies of normal and abnormal oral mucosa obtained from 14 patients were imaged with DCM [62]. Information such as mean fluorescence labeling intensity from fluorescence confocal images may add complementary information to that such as N/C ratio from reflectance confocal images, improving the ability to distinguish oral neoplastic lesions from normal tissue.
Wide-field imaging enables rapid inspection of large mucosal surfaces, to aid in the recognition of suspicious lesions. Neoplasia is associated with a loss of autofluorescence, and this approach can reveal lesions that are difficult to detect with standard white light examination. However, the presence of inflammation is also associated with loss of stromal autofluorescence, and may give rise to false-positive results with wide-field fluorescence imaging. By contrast, high-resolution imaging can probe epithelial changes with subcellular detail, comparable to that of conventional histopathology. Once suspicious regions are identified from wide-field images, these areas could be imaged with subcellular resolution using a high-resolution system potentially improving specificity. Wide-field and high-resolution images can both be analyzed objectively using image-processing algorithms to indicate disease probability, as demonstrated in previous studies [51]. The results of these algorithms can be used to flag suspicious regions on wide-field images in real time, designating target areas for high-resolution imaging. Similarly, high-resolution images can be analyzed to calculate morphologic features, such as average N/C ratio and nuclear separation. The combination of wide-field and high-resolution imaging may enhance the performance of optical imaging for real-time, objective detection of neoplastic changes. While multimodal optical imaging has shown interesting preliminary results, it has not yet been evaluated in a low-risk population. Moreover, the expertise requirement and cost–effectiveness of the technique needs to be evaluated before suggesting this for population-based low-risk screening. Finally, there is a critical need to engineer imaging systems that are appropriate for use not just in specialized clinics but for first-line practice settings, such as dental offices.
Rebecca Richards-Kortum serves as an unpaid scientific advisor to Remicalm LLC, holds patents related to optical diagnostic technologies that have been licensed to Remicalm LLC and holds minority ownership in Remicalm LLC. Ann Gillenwater has served as a paid consultant to Sanofi-Adventis, US LLC, has a minority equity interest in Onconome, Inc. and serves as an unpaid scientific advisor to Remicalm LLC. This work was funded through NIH grants R01 CA103830, RO1 EB007594 and R01 CA124319.
Financial & competing interests disclosure: The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
Papers of special note have been highlighted as:
■ of interest
■■ of considerable interest
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
Often, getting started is the most difficult part of any learning plan. Students are not born with time management skills or a tool box of ideas to help them move away from procrastination and into "pro-activation." That is why I made the graphic above. It describes a simple plan to help increase focus and decrease procrastination.
Additional tip - start with your most difficult work first.
For teachers, this cycle of focused work and breaks could also help you plan the flow of activities in your class to better address student focus.


text:
- Please select a date to see the proper prices!
Description of the accommodation:
Rooms, services Apartments Seagull Kos is glad to host the guests of RevNGo.com for some pleasant days in Greece. Guests looking for accommodation in Kos are welcome to book 14 nicely furnished rooms at the apartment. The exact list of services available at Apartments Seagull Kos (including those for an extra fee) and the exact list of equipment in a room can be found on the information sheet below.
Payment Depending on the selected date, room and price, you may need to provide credit card guarantee or advance bank card payment to finalize your reservation.
Arrival, opening hours The personnel is at your service in Greek and English languages.
Apartments Seagull Kos rooms Rooms
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Accommodation services
- Pool (Outdoor - seasonally open)


text:
GraphicRiver Relationship and Wedding People Icon Set 9195715
Stock Vector \ Miscellaneous
Wedding \ Proposal \ Honeymoon \ Couple \ Dancing \ Cutting \ Showing
Stock Vector - Relationship and Wedding People Icon Set 9195715 by neyro2008 @ GraphicRiver
Stock Vector \ Miscellaneous
Relationship and wedding people icon set showing a couple dating in love dancing proposal wedding kissing cutting the cake in a car on honeymoon and riding a motorcycle black silhouettes
Layered: No; Graphics Files Included: JPG Image, Vector EPS; Minimum Adobe CS Version: CS.
Vector Padlock Icons; Tools in Toolbox; Hand Drawn Angel Wings; Ice Cream; Allergies Icons; Celtic Patterns; Animals with Hearts on Valentines Day.
Keywords: cake, carrying, celebrating, clipart, couple, crossing, cutting, dancing, design, element, flowers, honeymoon, illustration, love, man, marriage, motorbike, nuptials, proposal, relationship, romance, romantic, social, threshold, transport, travel, valentines, vector, wedding, woman.


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What Makes תקליטן לאירועים So Addictive That You Never Want To Miss Oneposted on 14 Feb 2016 13:59 by johnathonkozusko
A wedding DJ takes treatment of the music dipped into the wedding event function as well as sees that the visitors are having a terrific time and also delighting in the songs played there. Nowadays it could be said that a wedding event is not complete if there is no DJ present to play some absolutely foot tapping numbers.
A wedding celebration DJ need to be able to really feel the pulse of the target market and also produce songs to set the mood for an excellent night. Right motifs for the event ought to be played and the part of a DJ at the wedding is extremely critical making it a most memorable event for the newly weds as well as the visitors too.
Besides the price of hiring a wedding celebration DJ there are a bunch of other vital elements that need to be thought about prior to choosing one. A DJ having the ideal type of musical devices will certainly be able to give a far better efficiency.
A DJ with a great track record and also that has actually beened around from some time with sufficient experience is going to create the right mood as well as spirit for the reception. The DJ ought to be versatile and have the ability to play music as asked for by the target market.
Much depends on the age of the wedding event DJ; a fairly more youthful individual will be in sync with younger group at the feature as well as be able to dole out the latest chart busters to keep the visitors dancing till the wee hrs. This DJ will undoubtedly be the very best option if the couple are young and their visitors are mainly from a comparable age.
But when the couple are elder their visitors are bound to be primarily from this age as well as they would certainly such as nothing yet the classics of the 70s or 80s and a DJ who is similar in age will certainly match finest.
Best is to obtain a DJ who will be able to cater to various age groups and can move from one sort of music to the other with relative ease. This is the one that will certainly be able to keep every person satisfied by coming prepared with a play listing to suit any age teams.
There are some who favor engaging a real-time band to give songs for the wedding celebration and the function, however they need to be prepared to invest a great deal more for employing their solutions.
Employ Wedding celebration DJ: Make Your Wedding celebration An Event Of Life time
Wedding celebration is an advantageous occasion where you intend to make the most from it. It is an event of a lifetime hence you intend to make sure that everything is done correctly as well as to the fullest. In earlier times, wedding celebrations were done primarily via conventional ways. There were not much lights and appear in the wedding event, instead even more of an easy wedding celebration which guarantees the boy and also female in a relationship. Nowadays, trends have actually changed, individuals turn to much more amusing objective in their wedding event. They located the occasion to be an occasion which requires far more enjoyable and also enjoyment. The wedding event generally last for 2-3 days with some pre wedding event features allocated to it therefore it asks for an event to keep in mind.
DJ: A brand-new trend
Ever before been to a bar? If you have after that you could have observed DJ'& rsquo; s rocking the dance flooring. He is the ultimate component of the clubs as well as dancing parties. With his skills, he could make you dance on the floor. DJ'& rsquo; s are not really limited to clubs nowadays, much has actually been transformed with the new world as well as they seem to have actually infiltrated in the wedding events. The majority of the features are consisted of with the event of dance parties. Such function unwinds you and also provides you the mean to have enjoyable. Wedding celebration functions are integrated with the idea of dancing events as well as DJ'& rsquo; s are the one to be sufficient the requirements of the home entertainment.
Amusement at its ideal
Throughout a lot of the time, you are barely visiting your pals, תקליטן לאירועים and also households gathered, other than for some festivals as well as events. However wedding is one such event where all your loved ones members are visiting unite as well as thus it ends up being crucial to make their time unforgettable as well as provide the most effective pleasure. What various other can be so perfect compared to having a DJ at the party? This is the finest means making your wedding celebration memorable and also everybody can remember it whenever you satisfy them.
Evening to keep in mind
Hiring a DJ for the wedding could consistently be attained with several methods. Ensure to inspect the costs and also solutions before working with one. Famous DJ'& rsquo; s will certainly cost you a whole lot hence prepare to vacant bunch of money on your weddings. Usually DJ'& rsquo; s bring their own tools & rsquo; s but some DJ may ask you to bring out the particular set of instruments hence clear out those problems before recruiting one. DJ'& rsquo; s generally play their own track of tunes which ideal fits the scenario but if you intend to make any sort of specific apply for concerning tunes after that you must notify him in advance. As soon as the offer is done, you have to give him a good location where he can establish his instruments. Envision, a wedding celebration with all the dance and also music on the flooring, it will definitely make your wedding even more compared to remarkable one. Whole lots of individuals nowadays resort to choose DJ'& rsquo; s in their weddings and also any kind of pre wedding celebration function since it produce the fun and change of the job.


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TITAN Salvage Lighters the New Flame
With personnel working around the clock for the past 10 days, the TITAN Salvage team in Gibraltar managed to reduce the weight of the New Flame's stern section by 300 tons to about 2,660 tons, thereby enabling the crane barge Rambiz to lift the piece free from the water and place it aboard the barge Giant III for onward transport to a scrapping facility. The achievement is the latest in a series of major milestones, in what is believed to be the largest wreck removal operation being undertaken in the world today.
About two weeks ago, TITAN successfully cut the stern section and engine room from the No. 5 cargo hold of the sunken freighter New Flame, then lifted the 3,000-ton section - with the help of internal lift bags and pontoons fixed to the hull - from the seabed off Europa Point.
The New Flame sank following a collision while exiting the port of Gibraltar in August. The ship was loaded with over 42,000 tons of scrap metal, which was being transported from New York Harbor to Turkey for recycling.


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Mrs. Driscol's Class
Assignments 2017-2018
Thinking Games
Challenge Assignment
Creative, Fun Online
Inspiring Videos
Photo Editing Sites
Technology and Gadgets
Careers with Technology
Funny, Weird, Interesting Videos
Homework Help
Assignments 2016-2017
Assignments 2014-15
Assignments 2013-14
Assignments 2012-13
May 2016 in 6th grade
Student - Cybersafety
Can you crack this case wide open? Are you able to find the answers people have been searching for for years and years? "Unsolved Mysteries" is counting on you for their weekly television series to present accurate information as well as your 'own take' on what really happened.
"Unsolved Mysteries" is counting on you. You must gain as much knowledge about the unsolved mystery you have chosen as possible. You will select a mystery to investigate. It is your task to find out what facts are available, report the theories behind the mystery ~ along with your own new theory. What supporting facts can you share that will support your theory? What still remains a mystery?
Once your have researched your information, answered the 5 questions necessary, you will then need to make some critical choices. How are you going to present your information to the world? Because you have come so highly recommended in your creativity and hard work, "Unsolved Mysteries" is willing to leave this choice up to you.
They have narrowed down the choices to best fit into their show format. Because time is money, you have will have a very limited amount of time to share your discoveries. You will have a
maximum of 4 minutes
of air time to share your findings with the viewing audience - this means you must be concise! This could be done in a variety of ways:
--> PowerPoint presentation (example in class)
--> 4-minute recorded video presentation
--> 4-minute live presentation with a visual display of some kind (backdrop - similar to science fair)
--> Prezi (we have not made these together in class)
Four minutes is not much time - be sure to be concise on what you plan to say. Best of luck with your decisions... "Unsolved Mysteries" is counting on you to share knowledge to their viewing audience and keep their ratings high.
Click here
to move on to the next step...
Quick Click Review
Below is a quick look at all the pieces/sites to this Unsolved Mysteries WebQuest. You should be able to follow your way through each page, but if you need to hop directly to a page, check out each statement below. Find the clipboard on each page, use should see these statements and should be able to navigate your way around.
--> I need to listen to the video explanation again,
click here
--> I need to re-read the introduction,
click here
--> I need to look over the 5 explanations (background, theories: reasonable and unreasonable, what still remains a mystery, my own theory,
click here
--> I need to check out the presentation part again - along with the "Dos" and "Don'ts" list,
click here
--> I need to get a look at those mysteries again,
click here
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text: New Super Mario Bros. Wii has got me in the mood for some more Mario. I know there are lots of Super Mario World hacks out there, but I don't know which ones to get or where to find them. Can anyone suggest some good ones and point me in the right direction? *Note* - I'm not necessarily looking for anything hard, just something that will be fun.


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The SPAR Summer Festival supports The Smile Foundation together with Cleft Friends and ask all participants to consider giving their support for this worthy cause.
All proceeds from the Castle Lite Beer Garden and the Wimpy Kids Zone goes to Community projects of the Rotary Club of Port Elizabeth Sunrise.
The only professional non-profit sport event organisation in the Eastern Cape offering exciting, and often different, sport events for the greater community.


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Popular Now
Popular Now
Popular Now
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01803 865913
+44 1803 865913
Edited By: Robert Lurz
308 pages, 5 tables
This volume is a collection of fourteen new essays by leading philosophers on issues concerning the nature, existence, and our knowledge of animal minds. The nature of animal minds has been a topic of interest to philosophers since the origins of philosophy, and recent years have seen significant philosophical engagement with the subject. However, there is no volume that represents the current state of play in this important and growing field.
The purpose of this volume is to highlight the state of the debate. The issues which are covered include whether and to what degree animals think in a language or in iconic structures, possess concepts, are conscious, self-aware, metacognize, attribute states of mind to others, and have emotions, as well as issues pertaining to our knowledge of and the scientific standards for attributing mental states to animals.
'... a highly stimulating collection of papers which considerably advances the philosophy of animal minds. It will be of interest both within the borders of philosophy of mind and in the rapidly expanding scientific disciplines involved with animal thought and feeling.' Notre Dame Philosophical Reviews
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This Rescue has been a long time consistant force in the Rescue World.
Impeccable Ethics, Fantastic Follow Thru, staying up on Continued Education & having fun. The volunteers are a warm friendly well trained group who all come together with a unified goal in mind. Saving, Re Training & giving these horses a second chance at a Productive life
I have seen them help Horses in need that I would have just most likely put down. I have been doing rescue for over 30 years. They are one of the best in Florida with helping horses. Like the pony Star, I would have never done everything they have done to save that pony even though she will never be a riding pony they have done everything to make her safe and comfortable and she has come much further than I ever thought she would!


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Bloomington, Indiana. A small city with a global mindset. Home to Indiana University. We helped Visit Bloomington articulate a brand platform to attract new travelers.
Bloomington literally means "a haven of blooms." For some, it's a gateway to the rest of their lives. For others, it's a homecoming. For many, it's a hub of creativity and inventiveness. To help Bloomington tell its story in a compelling way, we needed to find the common thread in all of these experiences.
First we had to understand the city. We hosted conversations with city stakeholders, surveyed leisure travelers and regional media, interviewed group travel planners, explored the city as tourists ourselves, and analyzed competitors and aspirational destinations in the Midwest.
From here, we identified the brand platform: Bloomington is a destination for idealists. It offers them a chance to escape the Midwest without leaving the Midwest. From morning yoga with Tibetan monks to concerts with indie bands who are about to hit it big. From micro-roasted coffee for breakfast to a farm-fresh dinner under the stars.
We built a visual identity and responsive website that respected the brand's heritage while bringing it into present day.
We defined audience segments based on traveler type: the big event set, the tastemakers, the health nuts, the cream and crimson, the lifelong learners, and the pragmatic planners, and we developed a brand voice that could speak to each of these audiences while staying true to the idealist spirit of Bloomington.
The social strategy encouraged people to tell Bloomington's story. Their first Instameet welcomed social media influencers to reach a combined audience of 189k and gain 11,385 organic likes, and Bloomington residents and IU alumni have shared Bloomington's videos with their own social networks. So far, they've earned 32.7k organic views on Facebook alone.
We secured press coverage, focusing on Bloomington's unique offerings. The city's progressive, bohemian culture earned glowing praise from journalists:
"If you haven't been to Bloomington lately, you may be missing out on some seriously cool new developments. Plus, at a mere 50 miles from Downtown Indianapolis, it makes the perfect destination for a day trip."
Gwen Ragno, Indianapolis Star
"For anyone new to Bloomington the best thing to do is find a parking spot near Kirkwood Avenue (good luck) and just venture down the street, whether you're sinking the biz at Nick's English Hut, having a farm-to-table meal at FARMBloomington, or picking up some vinyl at Tracks, you will get a small idea of the town."
Cavan McGinsie, NUVO
"The Kinsey Institute for Research in Sex, Gender, and Reproduction originated in Bloomington. The city's PRIDE Film Festival has been running for nearly a decade and a half. And, there are countless gay-friendly eateries, bars, coffee houses and other hangouts up and down its tree-lined streets."
Bryan Van Gorder, Out Traveler
Bloomington is for the different, the dreamers, the devil-may-cares. It's a place where natural beauty meets nurtured intellect. Whether they visit for a day or stay for a lifetime, idealists of all stripes find their place in Bloomington.
To view more of our work for Visit Bloomington, see our project showcase.


text: The many characters of ''TabletopGame/{{Pathfinder}}'':* [[Characters/PathfinderIconics Iconic adventurers of Golarion.]]* [[Characters/PathfinderAdventurePaths Individuals met along the various Adventure Paths in Golarion, and other mortals (and occasionally immortals).]]* [[Characters/PathfinderFactions The factions who control Golarion's politics.]]* [[Characters/PathfinderNations The countries and locations that fill up the maps.]]* [[Characters/PathfinderDeities The major deities and powers of the Great Beyond.]]** [[Characters/PathfinderArchfiends Demon lords, archdevils, and archdaemons.]]** [[Characters/PathfinderEmpyrealLords The Empyreal lords of the good-aligned planes.]]** [[Characters/PathfinderPantheons The Racial and cultural pantheons.]]* [[Characters/PathfinderClasses The many forms of adventurers in Golarion.]]** [[Characters/PathfinderRaces And the many races they come in.]]* [[Characters/PathfinderMonsters The myriad monstrous foes heroes are likely to encounter]]----


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Nothing quite compares to the terrors of looking in the mirror and noticing a new fine line, wrinkle or age spot that has magically appeared out of nowhere. As women, we are well aware of the dreaded aging process, but that doesn't make the experience any less upsetting. While we can't fight what nature has intended for us, we can certainly make the process more graceful (and less visible to the naked eye) with a little magic of our own. Here are some makeup tricks to turn back the hands of time.
1. Firm Up Your Foundation. Ever been to a holiday party and poured a little champagne in that punch bowl when no one was looking? Adding a firming serum to your foundation delivers the same type of kick, but to your skin! By adding a few drops of firming serum you've automatically upgraded your makeup to an antiaging treatment. Yes please!
Product Picks: Vichy LiftActiv Serum 10, Kiehl's Clearly Corrective Dark Spot Solution
2. Line Up. Lining the top lash line — as opposed to lining the entire eye — will make your eyes appear more youthful and awake (always a good thing). Want to up the ante? Use a colored liner like a purple or teal. Dark circles, bags and lines will be taking a back seat to your bright-eyed face!
Product Picks: Lancôme Paris Le Stylo Waterproof, Urban Decay 24/7 Glide-On Eye Pencil
3. Cream Blush. Instead of powder, opt for a cream-based formula that will give the skin more of a glow. A fresh pop of color on the cheeks is a great way to instantly lend your mug some youthful vibrance.
Product Picks: Maybelline Dream Bouncy Blush in Fresh Pink, L'Oréal Magic Smooth Soufflé Blush in Plume
4. Neutralize That Neck. Because of its hypersensitivity, the neck area is typically a dead giveaway to your age. Pull the wool over everyone's eyes by applying a little foundation (a la Step #1.) to the neck to cover any dark spots or pigmentation. Add some warmth with bronzer, which helps the skin appear more naturally smooth.
Product Picks: The Body Shop Baked-To-Last Bronzer, YSL Beauty Terre Saharienne 03
5. Bring On the Highlight. When in doubt (or in a rush) grab some highlighter. When the skin is brighter, it appears more supple and smooth. Highlight some common aging "problem areas" like the brows and under the eyes.
Product Picks: YSL Touche Éclat, Maybelline Instant Age Rewind Eraser Dark Circles Concealer + Treatment in Brightener
Although these tricks are great for day-to-day activities, it's important to fight the aging process while the makeup is off as well. Make sure you keep your skin hydrated and healthy by drinking lots of water. By doing this, you are promoting instant radiance. Also, apply an antiaging mask once a week (we recommend the Giorgio Armani Luminessence Mask). This will do wonders for your skin and give it a much-needed boost of free-radical protection.
If you could turn back time, what would you do differently? Let us know in the comments below!
About the Author:Ashley is a New York City-based makeup artist with a robust list of editorial and celebrity clients.
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Police Seek Car Related to Deadly South End Shooting
Boston Police said they are asking for the public's help to find a vehicle related to the deadly shooting of a young father in the South End early Saturday morning.
Detectives are on the lookout for a dark-colored, newer model Ford Explorer with a sun roof. Police said it was last seen near the scene of the shooting at 64 Aguadilla St.
Anyone with information about the vehicle is encouraged to call the Boston Police Homicide Unit at (617) 343-4470.
Neighbors and friends identified the victim as Niko E. Nunez, 20, and said he was in the wrong place at the wrong time, the Boston Globe reports.
Police continue to investigate the incident and have not confirmed the victim's identity or the circumstances surrounding his death.


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Al-'ard al-mubahah
Definition of "Al-'ard al-mubahah"
Lands not owned or occupied by any identifiable person. Also known as al-'ard ghair al-mamlukah. They are of three types: (i) the lands that provide common convenience to the inhabitants, such as streets, roads, drains, graveyards, mosques, grazing fields, etc. and cannot be owned by any particular person nor can the state impose proprietary restrictions on their use; (ii) the lands, consisting of jungles, barren fields, mountains, etc. that do not provide any common convenience, are not arable and are not owned by any one; and (iii) the arable lands not owned by anyone, also known as al-'ard li-bait al-mal.
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