text:
A Study of Bevacizumab to Prevent Malignant Ascites
This study has been withdrawn prior to enrollment.
(Accrual closed by sponsor due to lack of accrual and study progress)
Baylor College of Medicine
ClinicalTrials.gov Identifier:
First Posted: May 25, 2009
Last Update Posted: June 3, 2015
Genentech, Inc.
Information provided by (Responsible Party):
Martha Mims, Baylor College of Medicine
|Tracking Information
|First Submitted Date ICMJE
|May 21, 2009
|First Posted Date ICMJE
|May 25, 2009
|Last Update Posted Date
|June 3, 2015
|Start Date ICMJE
|July 2009
|Primary Completion Date
|February 2011 (Final data collection date for primary outcome measure)
|Current Primary Outcome Measures ICMJE
|To determine the repeat paracentesis response rate defined as a doubling of the patient's baseline time to repeat paracentesis. [ Time Frame: 12 weeks after initiation of study treatment ]
|Original Primary Outcome Measures ICMJE
|Same as current
|Change History
|Complete list of historical versions of study NCT00908219 on ClinicalTrials.gov Archive Site
|Current Secondary Outcome Measures ICMJE
|Original Secondary Outcome Measures ICMJE
|Same as current
|Current Other Outcome Measures ICMJE
|Not Provided
|Original Other Outcome Measures ICMJE
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|A Study of Bevacizumab to Prevent Malignant Ascites
|Official Title ICMJE
|A Prospective, Phase II Trial of Intravenous Bevacizumab (Avastin) for the Prevention of Recurrent Malignant Ascites
|Brief Summary
The purpose of this study is to determine the effectiveness of using Bevacizumab in the prevention of recurrent malignant ascites.
Ascites is a debilitating and unpleasant complication of several types of cancer. Animal and laboratory studies have shown that tumor cell production and/or increases in the amount of Vascular Endothelial Growth Factor (VEGF) is a major cause of the formation of malignant ascites. Therefore, giving patients with malignant ascites a drug that targets and neutralizes VEGF should prevent the recurrence of malignant ascites following paracentesis (a procedure to remove fluid from the abdominal cavity).
|Detailed Description
|All subjects will be treated with an intravenous infusion of the experimental drug (Bevacizumab 15 mg/kg) every 3 weeks for a total of twelve (12) weeks on study. The primary endpoint will be time to the need for repeat abdominal paracentesis after the start of therapy. Secondary endpoints will include an analysis of the mean number of paracenteses required in each subject over the course of 3 months, determination of the repeat paracentesis response rate (proportion of subjects who have a doubling in baseline time to repeat paracentesis) and an assessment of the effect of treatment on quality of life using a subject questionnaire.
|Study Type ICMJE
|Study Phase
|Phase 2
|Study Design ICMJE
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
|Condition ICMJE
|Malignant Ascites
|Intervention ICMJE
|Drug: Bevacizumab
Bevacizumab is given as an IV infusion of 15 mg/kg every three weeks for 12 weeks.
Other Name: Avastin; RO4876646
|Study Arms
|Experimental: Bevacizumab IV
All subjects will be treated with an intravenous infusion of the experimental drug (Bevacizumab 15 mg/kg) every 3 weeks for a total of twelve (12) weeks on study.
Intervention: Drug: Bevacizumab
|Publications *
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Enrollment ICMJE
|Completion Date
|February 2011
|Primary Completion Date
|February 2011 (Final data collection date for primary outcome measure)
|Eligibility Criteria ICMJE
Inclusion Criteria:
Exclusion Criteria:
|18 Years and older (Adult, Senior)
|Accepts Healthy Volunteers
|Contacts ICMJE
|Contact information is only displayed when the study is recruiting subjects
|Listed Location Countries ICMJE
|United States
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
|Has Data Monitoring Committee
|U.S. FDA-regulated Product
|Not Provided
|IPD Sharing Statement
|Not Provided
|Responsible Party
|Martha Mims, Baylor College of Medicine
|Study Sponsor ICMJE
|Baylor College of Medicine
|Collaborators ICMJE
|Genentech, Inc.
|Investigators ICMJE
|PRS Account
|Baylor College of Medicine
|Verification Date
|February 2012
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP


text:
Mobile workforce technology business Momote, which is headquartered in Newton-le-Willows, has formed a new partnership with Barcode Warehouse.
Soft drinks maker Nichols has reported a 14 per cent rise in group sales to £50.5 million in the six months to 30 June.
Plant hire firm Speedy Hire, which is based in Newton-le-Willows, has secured banking facilities worth £220 million.
Equipment rental firm Speedy has been chosen as an official supplier for this year's Manchester International Festival (MIF).
Kathryn Parsons, co-founder of Decoded, started with little more than faith and determination, but four years later it's grown into a global business. Ahead of her appearance at Accelerate 2015 in...
Author, writer and marketer Ryan Holiday on how entrepreneurs need to interpret failure.
Sue Vizard, business coach and author of Jump Start: The Start-up Book for Your Dream Business, looks at some of the questions solo entrepreneurs should ask themselves.
Ian Wright, founder and chief executive of NonExecutiveDirectors.com, is bringing together SMEs and NEDs - without the hefty recruitment fees.
Former professional golfer turned entrepreneur Colin Stevens has had a busy 18 months. The Better Bathrooms founder has increased turnover at the firm, secured a multi-million pound investment and...
Reputation is everything when it comes to running a successful business, according to Sacha Lord-Marchionne and Sam Kandel, founders of the Warehouse Project (WHP), a series of club nights featuring DJs from all over the world, which was launched back in 2006.
After travelling the world in a corporate role, Mike Wheeler decided that he had had enough of living out of a suitcase and so got a job running a small family business.
EN is an Excel Publishing Company Limited publication
All content ©2006-2015 Excel Publishing Company Ltd.

subset: commoncrawl


text:
It's Monday! What Are You Reading? is a meme hosted by Book Journey and is a great way for others to find out what you are planning to read this week and, best of all, see what others are reading.
Gone by Michael Grant
Big Frog by Rob Badcock
What are you reading? Read anything amazing lately??


text:
2007 Nissan Sentra - Consumer Review
Build Quality
Reliability Value
Build Quality
Reliability Value
9 of 11 people found this review helpful
Engine Replacement Already @ 82,000
By hmj8321 on
Vehicle2007 Nissan Sentra 2.0 4dr Sedan (2.0L 4cyl CVT)
ReviewI bought a 2007 Nissan Sentra 2.0 with a automatic CVT transmisson back in 2008... I have always keep up on my repairs, oil changes etc. The other day the service engine soon light came on so of course I took it in to be looked at. I was told by the mechanic that the engine needs to be replaced because the second cylinder has low compression which would run $3,000, What a joke! I have only had the car for a little over two years now... I was told by the mechanic that for the year the car was and how many miles it has on it (>82,000) that it should not have happened. Sentra's for the year 2007 are nothing but Lemons. I will never ever do business with Nissan again!
Recommend (9) (2)
Are you the author of this review?Update Your Review
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text:
Social Media Marketing (OMCP Preparatory)
- Course Delivery: On Demand
- Duration: 45
Social Media is evolving fast. How can you keep up with all the options, platforms, and trends, much less know which ones are worth pursuing? Take your training to the next level with comprehensive Social Media Training and learn not only how to use each tool but how to decide which strategy is better for which type of campaign and what kind of business. Jennifer Evans Cario and Greg Jarboe will give you everything you need to run your own highly successful social media campaign.
Whether you're new to digital marketing or a seasoned professional, this course will broaden your skill set and improve your ability to deliver real value for yourself, clients, and employers. Streaming video lessons, downloadable workbooks, and web-based quizzes and tests are all available online 24x7.
This course is preparatory for the OMCP™ Certification test.
Recommended prerequisites: Social Media Marketing Foundations
Topics Covered
Got questions? Contact us below or call 877-881-2235
Why Choose 360training.com?
- Fast and easy courses completion
- Get an education faster than at traditional colleges!
- 100% online - No classroom attendance required.
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text:
MyEssayWriting.com - Essay Writing Services.
The miller's daugther is in a trouble. A strange little man with a funny hat offers her his help, but she wants a lot in return...See what happens next in this classic story and share the quest for the little man's strange name.
Audio 11 MBNEW! - Better quality book - Improved pdf in the MIRRORS 53 MB


text:
- English
- français
Does the real part contain all the physical information?
Polarisation charge formed on nanostructure surfaces upon optical excitation provides a useful tool to understand the underlying physics of plasmonic systems. Plasmonic simulations in the frequency domain typically calculate the polarisation charge as a complex quantity. In this paper, we provide a pedagogical treatment of the complex nature of the polarisation charge and its relevance in plasmonics, and discuss how naively extracting the real part of the complex quantities to obtain physical information can lead to pitfalls. We analyse the charge distributions on various plasmonic systems and explain how to understand and visualise them clearly using techniques such as phase-correction and polarisation ellipse representation, to extract the underlying physical information.
- doi:10.1088/2040-8978/18/9/095002
- View record in Web of Science
Keywords: Nanophotonics ; Plasmonics
Record created on 2016-10-18, modified on 2017-05-10


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We went to visit my grandparents to see their new tenants, baby Robbins! They have one of those nest cameras so we sat contently watching the eggs, hoping for the mum to pop in.
Afterwards we went on a leisurely walk and just enjoyed the peace and quiet.
For lunch we had homemade pizza. I've learnt recently to make up dough and freeze it. When I'm really hungry I just don't have the patience to make it and wait an hour for it to rise. This way we just defrost it a few hours before and it takes no time at all to make it.
|Herbed Pancetta, Sweetcorn and Mozerella.
The rest of the weekend was spent in the garden. My parents recently re-did their decking, so we have been using the old wood to make planters. I say "we", but what I really mean is Ian making them and me sitting there, looking pretty and reading ; ) Ha! They are only half done but with a sand down and some paint they will look fab!
|Allium opening up.
Gemma x


text:
IML Survey is a SaaS (Software as a Service) App that operates with IML`s website. Please do not download this app unless you are or intend to ...
Discontinued App
Business | iPhone, iPad
Productivity | iPhone, iPad
Entertainment | iPhone, iPad
IML Survey is a SaaS (Software as a Service) App that operates with IML's website. Please do not download this app unless you are or intend to be a customer of IML Worldwide. IML Survey is a survey-based data collection app designed to enhance the meeting and event experience. The highly flexible app offers a wide variety of questionnaire formats allowing you to capture important information, preview results and download data. Respondents can answer questions at their own pace, with or without an internet connection. IML Survey is compatible with iOS tablets and smartphones supplied by IML and nicely complements IML's other solutions. The real value for key stakeholders of any meeting or event is the discussion, content and actions that are generated by the participants. IML Survey generates results that provide valuable insight during all stages of your meeting or event - from the discovery and planning phase to the live event itself. Use your findings to adapt your event to your attendees' preferences, for content generation, to help guide strategy, or to evaluate your meeting's success. How to Use IML Survey: 1. Download the IML Survey app onto your tablet or phone from the App Store 2. Run our free demo 'IML Survey Demo' to see features and example questions 3. Contact your local IML office to find out how it can help you at your next meeting or event Product Features: - Collect data with or without an internet connection - Directly collect data from the surveyors or run the survey in kiosk mode - Flexible question types - design survey questions and answers in a variety of formats including number, multiple choice, text, slider and more - Question flow logic - questions can be included or bypassed based on previous answers given - Ability to take photos and scan QR codes - Capture user signatures - Ability to record GPS coordinates - Customize surveys with your branding, colors, images and logos - Automatic email notifications for responses to questions designated as 'Hot Answer' - Real-time charts - results can be viewed in real-time and charted in a variety of formats - Download and analyze survey responses as soon as they are collected and in various data formats - Support for English, Spanish, German, Danish, French, Simplified Chinese and Portuguese
Version: 1.0
Size: 11.72 MB
Price: 0,00 €
Day of release: 0000-00-0


text:
|08 May 2013
Finally Got My VHS Tapes to DVD, including Sound, also editing!
I purchased a Honestech VHS to DVD Deluxe 5.0 Capture Device. I was able to capture my VHS tapes to DVD and laptop immediately with no problems. It did take a bit of time to learn how to edit, once I had them on my laptop.
The best part is I was able to get online support from the Honestech website--believe me when I say their techs were very very patient. I am female, 73, and really not Internet savvy. I did find I had to look at the diagrams in the online manual to study up on the terminology. Yes, you need to know if you are pointing to the Clip Panel, Preview Panel, Clipboard, Storyboard when describing where you are having problems.
Lucy (me): I open the video I captured and dragged it to the right.
Tech: I don't know what you are talking about.
Lucy: Oh, I dragged it to the left, not the right.
Tech: You have to be more clear
Lucy: da da da da da
The tech is finally beginning to understand what I am trying to do.
Tech: You drag..... and play video, .....
Lucy: Well I did that and when I da da da...
Tech: Are you done talking? I can't tell you how to... until you are done talking.
Lucy: da da da da da da
Tech: Are you done?
Lucy: Yes.
Tech: You .......
After this went on a few minutes I realized I wasn't talking to my little brother who is usually my Go To Guy for computer problems. He works on computers for large companies for a living but expects me to do as much on my own as I can before calling him with my troubles. He will kick in with his expertise when I come to a total halt. Why, is he so mean? Probably because he is also the Go To Guy for his many old lady siblings, a brother, their families and friends, his family and friends, and a life.
OMG, I can't believe the tech didn't just hang up on me! I had to tell him I felt like I had been talking to my brother. He pretty much has to stop me more than a few times to tell me to STOP talking and LISTEN.
I had purchased a Pinnacle VHS to DVD capture device previously, but was unable to capture the sound along with the video. I tried their online support and community groups, but was unable to get any meaningful help. So a big KUDO to Honestech for great customer support! Also, Best Buy, where I purchased my devices, provided some really good customer support.
|My System Specs
|08 May 2013
Win 7 Ultimate 64 bit
Were these home videos or commercial movies? I recently got the same converter from Amazon but haven't tackled using it yet.
|My System Specs
|08 May 2013
All home videos. Some as far back as 70 years ago (didn't have sound then), up until this year and captured sound along with videos.
|My System Specs
|20 May 2013
I am working on a tutorial for Dummies as I could find little help with the editing, etc. from any of the online video community forums. Although Honestech provides an online manual, it did not go into some of the details in depth. I could not have navigated through the editing of the videos without help from the online Honestech Customer Support Techs (both through their 800 number and email support).
In response to my question on creating a tutorial, "You are welcome to put up tutorials online. As long as you do not claim they are official videos from the company, you will be okay use the product for review and tutorial purposes."
I would like to create a video for You Tube (but that is another learning challenge), so my first endeavor will be a tutorial I will post on e-How. Yes, this device did everything it said it can do!
|My System Specs
|20 May 2013
Microsoft Windows 7 Home Premium 64-bit 7601 Multiprocessor Free Service Pack 1
I hope you don't think I am being condescending but I think what you have done is brilliant. And to think that you want to create a You Tube tutorial is even better. It's something of a challenge but providing your editing program will capture a live screen then go for it. I bet you succeed.
Good luck from this side of the pond!
|My System Specs
|Thread Tools
|Similar help and support threads
Good free video and sound editing application
Could someone recommended a good video and sound editing application. Preferable free. Thanks.
Editing the sound in Control panel
If you go to control panel/Sound & Sounds, I noticed that there are some programs there that I once had installed. Is there a way to remove/edit those old programs so that they no longer are listed? Tx
|Sound & Audio
Copy VHS tapes to DVD
I need to copy a few tapes to DVD. I have a VHS player/recorder, there seem to be a variety of bits and pieces for sale, would appreciate guidance on the best buy etc. Aspire 5742Z. 6GB DDR3. 640 HDD
|Music, Pictures & Video
Best Sound Editing Program?
Can anyone recommend a good sound editing program? I have been using Audacity but it is driving me nuts! It is SLOW and CLUNKY and frequently freezes and crashes on my system (Win 7 64-bit). There has GOT to be a better sound editor out there. What do you recommend? Thanks for any and all advice!
|Sound & Audio
Any good dynamic compressor for sound editing?
i need a software that can perform dynamic compression. say, to make CD music sound like a pop music FM station. i need it for sound (wave files) editing purpose. thank you
|Music, Pictures & Video
hook vhs player to computer to watch vid-tapes?
I have a combo dvd/video player. how can I hook it up to the computer to watch video tapes play real time on my monitor or even save them to the computer to record as dvd?
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text:
Quick Details
- CAS No.: 12001-26-2,13463-67-7
- Other Names: nail art mirror effect powder
- MF: Mica, Titanium Dioxide
- EINECS No.: 301-127-6, 236-675-5
- Place of Origin: Jiangsu, China (Mainland), Jiangsu, China (Mainland)
- Usage: Coating Pigment, Cosmetic Pigment, Ink Pigments, Leather Pigments, Plastic & Rubber Pigment
- Brand Name: KOLORTEK, kolortek
- Model Number: nail art mirror effect powder, chrome nail powder
- Type: Titanium
- Style: Inorganic Pigment
- Product Name: Kolortek nail art mirror effect powder chrome pigments factory
- Form: powder
- Partilce Size: 10-60 microns, 15-250microns
- Mesh: 200, 400, 800
- Color: sliver
- Certification: FDA
Packaging & Delivery
|Packaging Details
|25 kgs Per Carton Or Drum, 300 kgs Per Pallet for Kolortek nail art mirror effect powder chrome pigments factory
|Delivery Time
|Shipped in 7 days after payment
Kolortek nail art mirror effect powder chrome pigments factory
KOLORTEK chrome nail powder
Mirror powders are carried in ethyl acetate and isopropyl alcohol. These pigments are made from specially selected spherical aluminum powder. The average particle size curve is narrowly controlled and under proper formulation which impart a bright appearance with good coverage ability.
Properties of chrome nail powder ( mirror nail powder )
Most perfect nonleafing behavior of all metallic pigments
Strongest flop effect of all metallic pigments
Best hiding power of all metallic pigments
Highest brilliance of all metallic pigments
Excellent intercoat adhesion
Most suitable for tinting
Perfect rub resistance
Mirror powder pigments are currently being offered to the ink and paint manufacturing industries. Because the main requirements of the paint and ink industry were pretty similar: brilliance, lightness, hiding power and strong flop or two tone effect (angle dependent lightness of an application) combined with perfect no leafing behavior, essentially a micro mirror.
Packing: 25 kgs Per Carton Or Drum, 300 kgs Per Pallet for chrome nail powder .
To support all the demanding customers, Kolortek is going to focus on value addition in order to satisfy the needs of all our customers. The valued-added service spans:
1.Special Packings
2.Own Brand Labeled
3.Product Images Support
4.Formulation Guideline Support,etc
Kolortek Co., Ltd. is a leading professional manufacturer of effect pigments, and cosmetic color additives, specializing in pearl pigments, cosmetic iron oxides, mica powders and cosmetic
fillers, etc.
1. We accept T/T, Western union and Paypal Payment.
2. Shipping with FEDEX and DHL to your door.
3. Samples are available, please send us your address with the post code.


text:
I Felt Like I Had a Connection to At Least One Person
Personal Stories, Advice, and Support 8 People
Soul ConnectionsI have many connections in life. I can feel each of these persons' emotions deep within my soul. There are some that I have a deeper connections than others and this connect spans oceans and miles. Yes, I love my connections to peoples' souls. ions.
fungirlmmm 46-50, F 1 Response 0 Mar 23, 2010


text:
Senate Democrats to try passing debt ceiling increase
lost in DC West Jordan, UTOct. 9, 2013 11:51 a.m.
One vote,
The situation is negative because harry and BO made it that way.
You hit the nail on the head. BO says he refuses to negotiate until the government is re-opened. He NEVER negotiates unless some crisis is staring him in the face – unless there is some type of cliff.
Obamacare does NOT provide healthcare. It is NOT a healthcare bill. It is an INSURANCE bill. Sorry the dems have confused you so on that point.
No need to default on the debt as long as Lew abides by the constitution. But since he is a dem, and would therefore damage the country as much as possible to score political points, I'm sure he'll apply any available funds to something other than paying the debt service.
Slavery was once the law. Only white male landowners could vote – that was also the law. It took more than legislative processes to change. Obamacare required no funding before, so that tactic was not available – until now.
Also, tell us why you are not holding BO accountable for his failure to enforce the employer mandate since Obamacare is the law.
Itsjstmeagain Merritt Island, FlOct. 9, 2013 6:35 a.m.
Think ahead to 2015 when the full Congress is owned by the Democrats. What laws were passed by previous Congresses that the Left does not like. Will we see a Government by Retribution, that will annually bring the Country to and probably over the ledge? I hope not. There should be no first time example defunding in a Continuing Resolution like this.
The ACA is simply the law today. The Congress made no fewer than 40 attempts to repeal it during the Legislative session (the right time) without success. Any attempt to defund or reduce funding for the ACA should be done when someone starts building a budget for FY2014 and out as requested by the President.
SCfan clearfield, UTOct. 9, 2013 6:31 a.m.
Since we are roughly 17 trillion in debt now, what's a few trillion more. The Republicans should give the Democrats what Obama and the Senate want, and then stand back all the while saying they didn't want this increased debt. When the economy falls off the cliff, the blame will be totally with the Democrats, and Obama if he is still in office. One thing is for sure. This debt is like a road directly toward the Grand Canyon with no exits. Either we turn around, or the country will do a Thelma and Louise.
Baron Scarpia Logan, UTOct. 9, 2013 5:51 a.m.
Other newspapers are reporting that increasing numbers of GOP congressional leaders say that default will not be catastrophic... Go ahead, America, go into default, they say. Imagine what will happen to Wall Street and Main Street!
So here's the GOP logic:
Nation defaults on its financial obligations: Okay.
Obamacare providing healthcare to those who need it: Catastrophic.
What has happened to the GOP? They used to be the party of business. Now, they're are so ideological in their hatred of all things "Obama" that they're taking the nation to financial ruin... It is like, "let's kill the patient so the operation will be a success!"
We need the GOP to return to its pro-business orientation -- creating certainty and a favorable business climate for job creation and prosperity for all Americans. By allowing the nation to default on its financial obligations, it is creating significant UNCERTAINTY in the marketplace, and it will create unemployment and lost business opportunity. Sad.
4word thinker Murray, UTOct. 8, 2013 8:51 p.m.
Why is the debt clock still rocketing up when the government is shut down?
Brahmabull sandy, utOct. 8, 2013 3:49 p.m.
All Barry Obama has to do is drop the unaffordable care act, and bingo the government can re-open. It isn't a viable long or short term plan, it doesn't help most middle class americans, and it isn't affordable. Drop it Obama.
ChristoperB Salt Lake, UTOct. 8, 2013 3:22 p.m.
Stop spending money we don't have barack.
You've increased our national debt at never before seen amounts.
Badger55 Nibley, UtOct. 8, 2013 2:23 p.m.
"The fact that we are here today to debate raising America's debt limit is a sign of leadership failure. It is a sign that the U.S. Government can't pay its own bills. It is a sign that we now depend on ongoing financial assistance from foreign countries to finance our Government's reckless fiscal policies...Increasing America's debt weakens us domestically and internationally. Leadership means that ''the buck stops here.'' Instead, Washington is shifting the burden of bad choices today onto the backs of our children and grandchildren. America has a debt problem and a failure of leadership. Americans
deserve better. I therefore intend to oppose the effort to increase America's debt limit."
-Sen Barack Obama March 16. 2006
Badgerbadger Murray, UTOct. 8, 2013 1:28 p.m.
The democrats promising to negotiate after the debt ceiling has been raised and the government has been funded is like Lucy promising to hold the football for Charlie Brown. As soon as republicans go for it, they will pull all that has been promised away.
I am not falling for it. I hope republican congressmen/women won't either.
Jordan Lynchburg, VAOct. 8, 2013 1:06 p.m.
This seems to be destroying our nation. Go into even more debt in order to pay off some debt? In what world does that make sense?
AChapin Albany, Linn, OROct. 8, 2013 11:52 a.m.
I see a slight sign of Marshall Law here. Do not surrender or quit. The price is too steep.
Aloha / Shalom
Gildas LOGAN, UTOct. 8, 2013 8:28 a.m.
What can any honest person say, or one with one iota of common sense. What can an LDS person say?
Pay debt obligations but do not agree to borrow more. If there is a debt ceiling, reduce it as soon as possible. Social Security btw is a debt obligation; the money borrowed from it by Congress is represented as part of its debt obligations. I say that as many seek to reneige on those bills of indebtedness.
We need to trim down bureaucracies and eliminate many, some regarded by the administration as unnecessary. There needs to be a constant pressure by Congress to live within our means. We need to stop policing the world and entering wars except for the immediate defence of the nation "from all enemies foreign and domestic".
one vote Salt Lake City, UTOct. 8, 2013 7:05 a.m.
This is a positive move to turn around the negative situation created by conservative tea party.


text:
Sitting on its own estuary, Kingsbridge is a market town with a friendly atmosphere in the heart of this Area of Outstanding Natural Beauty. Twice a month a Farmers Market is held in the town, giving you the chance to pick over freshly, locally grown produce with not a cellophane wrapper in sight.
If you want to catch a film check out the independent Reel Cinema in the town. Behind the old-fashioned façade you'll find 3 screens, multiplex seating and the chance to see blockbusters alongside something a little more avant-garde.
An island adventure
The area is popular with walkers and water sports enthusiasts. Close by is Bigbury beach, where at low tide you can walk across the sand to Burgh Island, the setting for the Agatha Christie novel 'Evil under the Sun'. At high tide a sea tractor can take you across – a trip not to be missed, and especially popular with young children, which gives you the perfect excuse to stay on the island a little longer by sampling the hospitality offered at The Pilchard Inn. The beaches here are also a magnet for surfers, with lessons and board hire available for all abilities.
Fantastic local produce on the doorstep
If plants and gardens are more your thing then pop over to Fast Rabbit Farm and Gardens. Set in 30 acres of the Strawberry Valley, it offers good accessibility and the chance to pick up a floral reminder of the day in the attached plant shop.
Nearby Aune Valley Meat is an award winning butchers, deli and farm shop. If you're giving yourself the day off cooking then enjoy their wares at their café – their 'butchers breakfast' is a great way to prepare for a day exploring.
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text:
On 20-2-1978 Julia Jentsch (nickname: ) was born in Berlin. The actress is in 2017 famous for Sophie Scholl – Die letzten Tage, Hier kommt Lola!, The Edukators. Julia Jentsch's starsign is Pisces and she is now 39 years of age.
Currently no cars listed on Taddlr
- 10 incredible celebrity houses & cars
Who is Julia Jentsch dating in 2017?
Will the marriage of German actress Julia Jentsch and current Husband, Christian Hablützel survive 2017? Vote!
[purple_heart_rating] Must read: 2017's Hottest celebrity wives and girlfriends!
Official websites/fansites: www.juliajentzsch.com
Does Julia Jentsch have official Social Media profiles?
Discuss the latest gossip and rumors (Plastic surgery, Scandals etc) and post the latest photo's and video's of Julia Jentsch here:
Facts & TriviaWhere does Julia Jentsch live? And how much money does Julia Jentsch earn?
|Birth date
|Religion - believes in god?
|She lives together in a house in München
|Estimated Net worth
|6 million Dollar 2017's Top 20 richest actresses!
|Yearly Salary
|N/A Salaries of TV's best paid actors
|Product Endorsements
|Slant Magazine
- Sponsored links -
Possessions, fortune & earnings
- 10 incredible celebrity houses & cars
Love, Family & Friends
|Relationship status
|Married (Since 2012)
|Current Husband of Julia Jentsch
|Christian Hablützel
|Ex-boyfriends or ex-husbands
|Expecting a baby
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Body Measurements & HealthThis beautiful gracious actress originating from Berlin has a slim body & triangle face type.
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By Joe Haggerty
CSNNE.com Bruins InsiderFollow @hackswithhaggs
BOSTON Its probably no surprise that the home teams are dominating in this years Stanley Cup Final like no either in recent memory.
The3,000-plusmiles that separate Boston and Vancouver represent the longest distance between two NHL teams ever engaged in a Cup Final, and the cross-continental travel has been grueling after the first five games of the series.
The long flights between the two cities seem to have been a factor -- maybe even more so than the matchup advantages given to the home teams that get the last line change, or the volume of the home crowds.
So far in the series, the home team has won every game and outscored the visiting team by a combined score of 17-3. The travel has to be partly to blame. But it's more than that, at least according to the Bruins.
Shawn Thornton talked about not playing with enough desperation in Game 5, and he regretted that his team gave a lackluster effort with the Stanley Cup on the line.
Zdeno Chara inspired the Bruins with a rare speech to the team between the first and second period of Game 3 after Nathan Horton went down with a severe concussion, and that gave them an edge in a pair of punishingly physical games in Boston. Chara said it was the edge that was missing from the teams game when they traveled to the West Coast.
We play a lot more on the edge in Games 3 and 4, said Chara. We have to bring the same approach for Game 6. Obviously its very important to be playing physical. We know what kind of team we have and what plays to our advantage. So we just got to get back to it.
Yet, for all the physicality the Bruins would like to bring, they aren't able to do it if they have tired legs, which is what seemed to be the problem in their Game 5 loss.
The Bs had enough energy and gas in the tank to hold down the high-powered Canucks offense, but the Black and Gold skaters had little left to give in the third period. It was the third time in three games in Vancouver when they seemed sapped in the third period.
That's usually when Cup-worthy hockey teams dig down into untapped reserves of energy and emotion, but the Bruins could not.
The Canucks have outshot the Bruins by a 32-26 margin in the third periods in Vancouver, and have outscored the Bs by a 3-0 margin while pulling away in the final 20 minutes in each of Bostons road games.
Thats the sign of a hockey team that's playing tired, and its likely the sign of an Eastern Conference team not used to the sheer amount of travel required going back and forth across the continent.
It just didnt seem like we had our energy, said Marchand. Everyone seemed a little slow and our legs just werent going. So we just have to make sure we leave everything on the ice next game, and if we go down, we go down fighting.
The Canucks have hired sleep consultants and gone outside the box to maximize their ability to withstand the rigors of their challenging schedule. And they're the team that is more used to long flights.
This is all new territory for a Bruins team that didnt have to fly more than three hours at a time for any other playoff series leading up to the finals.
The good news: Boston gets two off days before hosting the Canucks at home in Game 6, and Vancouver has looked exhausted for its two games in the Hub.
Everything in the series points to the Bs taking Game 6 in front of their excitable home crowd, but if they do, they will have to find a way to summon their legs for a winner-take-all Game 7. What makes that even more difficult? Just one off-day for the cross-country travel.
Its a problem the Bruins will have to solve if they hope to kiss the Cup.
Joe Haggerty can be reached at firstname.lastname@example.com. Follow Joe on Twitter at http:twitter.comHackswithHaggs


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GraphicRiver Isometric White Airplane in Rear View 4821253
Stock Vector \ Conceptual
Airplane \ Isometric \ Illustration \ Airbus \ Possible \ Editable \ Easily
Stock Vector - Isometric White Airplane in Rear View 4821253 by aurielaki @ GraphicRiver
Stock Vector \ Conceptual
Detailed illustration of a Isometric White Airplane in Rear View
This illustration is saved in EPS10 with color space in RGB.
Where possible, the objects have been grouped to make it easily editable or hidden.
Layered: Yes; Graphics Files Included: JPG Image, Vector EPS, AI Illustrator; Minimum Adobe CS Version: CS.
Poster Invite for Circus Party with Elephant; Isometric Road Signs Set on Green Terrain; Isometric Tourists Peoples Set in Various Position; Invite for Halloween Party with Witch; Floreal Vintage Wedding Invite; Isometric Building Construction Mega Set; American Vintage Patriot Wedding Invite.
Keywords: Commercial Airplane, air, airbus, aircraft, airliner, airplane, airport, arrival, asphalt, aviation, boeing, bus, cargo, engine, fly, ground, isolated, isometric, jet, journey, ladder, passenger, pilot, plane, shuttle, staircase, transport, travel, vehicle, wing.


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Autopsy of the Dead Trailer (2009)
"In 1968, the dead walked. Now, the dead will talk." 22 September 2009 144 mins
Board up the windows and doors! More than 40 years after filming the 1968 horror masterpiece Night of the Living Dead, the 'dead' return in the all-new documentary Autopsy of the Dead. Packed with extensive cast & crew interviews, never-before-seen color photos and behind the scenes footage, visits to the original filming locations and other surprises, get ready for the most in-depth visual document on the making of the great American horror film that won t stay dead.
Watch the official Autopsy of the Dead 2009 trailer in HD below or find more Autopsy of the Dead videos on Vidimovie.


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Population: 57,600 (July 2009 estimate)
Capital: Nuuk
Area: 836,330 square miles (2,166,086 sq km)
Coastline: 27,394 miles (44,087 km)
Highest Point: Gunnbjorn at 12,139 feet (3,700 m)

Greenland is a located between the Atlantic and Arctic Oceans. It is technically a part of the North American continent but historically it has been more linked with European countries like Denmark and Norway. Today, Greenland is considered an independent territory within the Kingdom of Denmark. As such, Greenland is dependent on Denmark for the majority of its gross domestic product.

By area, Greenland is distinctive in that it is the world's largest island with an area of 836,330 square miles (2,166,086 sq km). It is not, however, a continent. Due to its large area and small population of 57,600 people, Greenland is also the most sparsely populated country in the world.

The following is a list of ten interesting geographic facts about Greenland:

1) Greenland is thought to have been inhabited since prehistoric times by various Paleo-Eskimo groups; however, specific archaeological research does show the Inuit entering Greenland around 2500 B.C.E.

2) European settlement and exploration of Greenland did not occur until 986 C.E. when Norwegians and Icelanders settled on its west coast. These people were eventually known as the Norse Greenlanders and they were formally taken over by Norway in the 13th century. In that same century, Norway entered into a union with Denmark which effectively started Greenland's relationship with that country as well.

3) In 1946, the United States offered to buy Greenland from Denmark but the country refused to sell the island. In 1953, Greenland officially became a part of the Kingdom of Denmark and in 1979 Denmark's Parliament gave the country powers of home rule. In 2008, a referendum for greater independence on Greenland's part was approved and in 2009, Greenland took over the responsibility of its own government, laws, and natural resources. In addition, Greenland's citizens were recognized as a separate culture of people. Denmark still controls Greenland's defense and foreign affairs.

4) Greenland's current head of state is Denmark's queen, Margrethe II.

5) Because of its very high latitude, Greenland has an arctic to a subarctic climate with cool summers and very cold winters. For example its capital, Nuuk has an average January low temperature of 14°F (-10°C) and an average July high of just 50°F (9.9°C). Because of this, its citizens can practice very little agriculture and most of its products are forage crops, greenhouse vegetables, sheep, reindeer, and fish. Greenland mostly relies on imports from other countries.

6) Greenland's topography is mainly flat but there is a narrow mountainous coast. Most of Greenland's land area is covered by an ice sheet (map) and two-thirds of the country is subject to permafrost.

7) This massive ice sheet found in Greenland is important to climate change and has made the region popular among scientists who have worked to drill ice cores. They have done this to understand how the Earth's climate has changed in the past. In addition, because the country is covered with so much ice, it has the potential to significantly raise sea levels if the ice were to melt with global warming.

8) Greenland's capital, Nuuk, is one of the world's smallest capital cities with a population of only 15,105 (July 2009 estimate).

9) All of Greenland's cities are built along the coast because it is the only area in the country that is ice-free. Most of these cities are also along Greenland's west coast because the northeastern side is comprised of the Northeast Greenland National Park.

10) Greenland's name originated with Scandinavian settlers, particularly Erik the Red when he was exiled from Iceland. It is believed he called the area Groenland (translated as "Greenland") to attract more settlers to the area.

References

Central Intelligence Agency. (2010, April 22). CIA - The World Factbook - Greenland. Retrieved from: https://www.cia.gov/library/publications/the-world-factbook/geos/gl.html

Wikipedia. (2010, April 26). Greenland - Wikipedia, the Free Encyclopedia. Retrieved from: http://en.wikipedia.org/wiki/Greenland


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Changes in the tax rates have made knowledge of trusts and estates all the more important. This course examines more advanced tax issues that CPAs grapple with and explores how the new tax environment impacts planning for estates, trusts, and their beneficiaries. It also presents a discussion of the generation-skipping transfer tax implications of trusts and estates.
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Revisiting Prague: Obama's response to the threat of nuclear exchange
While there are substantially fewer nuclear weapons today than during the Cold War era, the overall risks of nuclear war have actually expanded.
More states in more unstable regions have attained such weapons, terrorists continue to pursue them, and the command and control systems in even the most sophisticated nuclear-armed states remain susceptible to not only system and human error but, increasingly, to cyber-attack. Recent developments pertaining to North Korea and Iran, as well as the nuclear capacity of Israel, Pakistan and China, mean the risks associated with "loose" nuclear material and stockpiles are not farfetched, nor exaggerated. Given this, the role, efforts and policy initiatives (or lack of) of the US Administration could have a decisive impact on the extent to which real nuclear reductions are made, and thwarting the 'calamitous global consequences' of even a limited nuclear exchange. In building upon previous research, this paper will evaluate the Obama Administration's second term in reaching for the lofty goals posited at Prague in 2009. Having fallen disappointingly short at the end of his first term, the paper will examine the extent to which Obama has attempted to realign the tensions between policy and implementation in areas pertaining to disarmament, as well as the extent to which the Administration has garnered traction in mobilizing political will towards "ending Cold War thinking" in the lead up to the November 2014 mid-term elections.
Speaker: Aiden Warren
Wednesday 24 September: 12.30 pm to 2.00 pm
Industry Engagement Room, Building 37, Level 3, Room 18


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Skip to comments.STOCKS SMASHED AS EXISTENTIAL FEAR COMES BACK WITH A VENGEANCE: Here's What You Need To Know
Posted on 07/11/2011 1:27:15 PM PDT by blam
STOCKS SMASHED AS EXISTENTIAL FEAR COMES BACK WITH A VENGEANCE: Here's What You Need To Know
Joe Weisenthal
Jul. 11, 2011, 4:00 PM
Image: European Southern Observatory
Today was a day of pondering existential threats to entire political/financial systems. Not surprisingly, everything sold off pretty hard.
But first, the scoreboard:
Dow: -142.35
And now, the top stories:
* All weekend we talked about Italy, and then guess what: Italy crashed today: After opening down just a modest 1%, the main FTSE MIB index fell 3.9% (though at one point it was closer to down 5%). Bonds yields ripped higher like crazy, in a move that truly threatens the eurozone in an existential manner. Italy is too big to rescue.
* Stepping back a moment, there was negative news out of China over the weekend: Inflation was hotter than expected and imports were slower than expected. Partly due to that, and partly as a response to Friday's weak jobs report, most Asian markets had a rough night. (Shanghai actually ended higher, though Hong Kong got smashed).
* In the US there was no data. Everyone's watching the debt ceiling fight out of the eye that they're not using to watch Europe. The two sides aren't anywhere close. Both Boehner and Obama held press conferences that confirmed how far the two sides are apart. Today's negotiations wrapped up just after 3:30.
* So between Italy, the rest of the PIIGS, Chinese inflation, and the debt ceiling crisis, it was a perfect recipe for a stock drubbing. The dollar surged and gold surged, while the industrial commodities got hammered. The euro got killed.
* In terms of corporate news, there are a few things of note, as earnings season
(Excerpt) Read more at businessinsider.com ...
You call that a plunge? I can still remember -1200 a couple of hours two years ago.
Today was just a hiccup. I actually bought some stock today. That's what you do on down days and sell on up days.
The latest beginning of the end?
An existential crisis is a stage of development at which an individual questions the very foundations of his or her life: whether their life has any meaning, purpose or value.[1] This issue of the meaning and purpose of existence is the topic of the philosophical school of existentialism.
If you ask me the stock market is an inflating bubble. It should have popped long ago but it just keeps getting higher and higher.
The good news remains this, nobody has a clue what to do. Therefore, the markets continue to be an argument. Let all the prophets dance on pins with speculative guesses and predictions. As for me, The Broker has seen much worse and much better.
I really don' know what I'm talking about. But it sounds good, doesn't it?
" overbearing entanglements which can devastate the US economy "
Our 'devastation' is mostly self-inflicted....
I can still remember -1200 a couple of hours two years ago.
Man, did that hurt!
I really don know what I'm talking about. But it sounds good, doesn't it?
Hey, that kind of aproach got obama elected and he still doesn't know what he's talking about;) BTW, it did sound good.
I've been treating it like a "suckers" rally ever since I regained the $$ I lost in the crash.
Gentlemen, get ready for the stock market to drop at least 2,000 when the "ONE", and Timothy Geithner pull out the federal money they invested to artificially prop up the market.
They will have no choice, because the money will be needed elsewhere to prop up other sectors of the economy so it will look like Obama is doing a good job for re-election.
It won't work, because the market will fall farther as Obama will realize he faces a landslide loss in Nov 2012. Then about November 15 as the reality of what the voters said sinks in, the market will start climbing again. Businesses will start hiring around December for a big Shopping season as Americans begin to feel good about the future, and the feeling will carry into the new year as the big money men start to loosen up their cash to invest.
In the meantime, gold will hit about $1,800.00 to &2,000.00 and even after the dizzying effects of Obama's end subside, gold will settle around $1,700.00 as the dollar begins to gain strength against the backdrop of Europe's continuing troubles.
I talked to God and He said so. Well, he left an impression upon my so strong as to make me feel as such anyway. Mark this day on the calender and get back with me in February 2013. You will learn that I am right, because the world needs to be thriving in order for men to turn from God in droves, and turn to the world and the new world order which will be ushered in by a Republican.
Rem,ember, Christ will return because men reject him for the world, and that will only happen in a robust economy when all men are doing good. In bad times men turn to God, in financially good times they turn from him.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


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That's great for you and the dealership because the cars are in perfect condition when they arrive on the dealer lot. And of course it's the dealership's job to protect the inventory from the damaging elements while it is at the dealership. The question is: Who is going to protect your investment now?
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Microsoft Prevails In Appeal Of Extensible File Patent Rejection Before PTAB
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One manifestation of age-related declines in vascular function is reduced peripheral (limb) blood flow and vascular conduction at rest and in response to vasodilatory stimuli such as exercise and feeding. Since, even in older age, resistance exercise training (RET) represents an efficacious strategy for increasing muscle mass and function, we hypothesized that likewise RET would improve age-related declines in leg blood flow (LBF) and vascular conductance (LVC). We studied three mixed-sex age groups (young: 18–28 yr, n = 14; middle aged: 45–55 yr, n = 20; older: 65–75 yr, n = 17) before and after 20 wk of whole body RET in the postabsorptive state (BASAL) and after unilateral leg extensions (6 × 8 repetitions; 75% 1 repetition maximum) followed by intermittent mixed-nutrient liquid feeds (∼6.5 kJ·kg−1·30 min−1), which allowed us to discern the acute effects of feeding (nonexercised leg; FED) and exercise plus feeding (exercised leg; FEDEX) on vascular function. We measured LBF using Doppler ultrasound and recorded mean arterial pressure (MAP) to calculate LVC. Our results reveal that although neither age nor RET influenced BASAL LBF, age-related declines in LBF responses to FED were eradicated by RET. Moreover, increases in LBF after FEDEX, which occurred only in young and middle-aged groups before RET (+73 ± 9%, and +90 ± 13%, P < 0.001, respectively), increased in all groups after RET (young +78 ± 10%, middle-aged +96 ± 15%, older +80 ± 19%, P < 0.001). Finally, RET robustly improved LVC under FASTED, FED, and FEDEX conditions in the older group. These data provide novel information that supports the premise that RET represents a valuable strategy to counter age-related impairments in LBF/LVC.
- circulation
- nutrition
- muscle
human ageing is associated with decreased arterial compliance, which leads to hypertension and coronary artery disease (10, 11, 20) such that cardiovascular disease-related morbidity and mortality increase markedly with age. Declines in peripheral (i.e., limb arterial) blood flow and increases in vascular resistance are one such characteristic manifestation of cardiovascular ageing. For example, Donato et al. (13) reported that older individuals exhibit 20–30% lower resting, postabsorptive limb blood flow and a ∼50% decrease in leg vascular conductance (LVC) compared with younger individuals. Such age-related changes are purported to contribute to the metabolic syndrome, a major precursor to atherosclerotic disease in humans that encompasses hyperinsulinemia, dyslipidemia, and hypertension (20).
Intriguingly, declines in peripheral blood flow with ageing are not restricted to postabsorptive periods but are also observed when subjects are challenged with vasodilatory stimuli, such as food intake (31) and exercise (13, 25). For example, characteristic increases in limb (forearm brachial) blood flow in the postprandial period are impaired in both older and diabetic adults (31), with age rather than diabetes being the principal determinant. Furthermore, compromised exercise hyperemia has also been demonstrated with elderly men displaying 20–30% lower LBF and LVC than younger men at various exercise workloads (13) of knee-extensor exercise or whole body bicycling (13, 25).
Significantly, both functional and metabolic consequences of declines in LBF responses to feeding and exercise have been suggested. First, decreases in LBF during/after exercise may explain decrements in functional performance and recovery [e.g., O2 delivery, metabolite clearance, etc. (37)] in ageing skeletal muscles. Second, as LBF regulates delivery of insulin and amino acids for metabolism in skeletal muscles (8, 36) reduced LBF can contribute to declines in insulin sensitivity and muscle protein anabolic responses to both feeding and exercise (3, 5–7, 15, 37) with age. Thus it is likely that avenues for maintaining both resting postabsorptive LBF as well as "acute" responses in LBF to vasodilatory stimuli such as exercise and feeding represent an important avenue for preserving muscle health with ageing.
Muscle strength is inversely correlated with all-cause mortality (21), and age-related declines in both muscle mass and strength are associated with comorbidities such as falls, fractures, and progressive disability (27, 28). Although it has been long known that resistance exercise training (RET) improves muscle mass and function, even in elderly subjects (33), RET has also shown novel efficacy such as modulating cardiovascular risk (9) and ameliorating age-related declines in postabsorptive LBF (1, 22, 34). Therefore, we hypothesized that RET could ameliorate age-related declines in LBF and LVC not only under postabsorptive conditions but also in responses to the vasodilatory stimuli of food intake and exercise. Specifically, adopting a unilateral (i.e., one-legged) acute exercise protocol enabled us to measure LBF and leg vascular conductance (LVC) both before and after 20 wk RET under three conditions: 1) BASAL: postabsorptive; 2) FED: in the nonexercised leg after feeding; and 3) FEDEX: in the exercised leg after feeding.
Subject Characteristics
We recruited three groups consisting of young [Y: 24.9 ± 3.5 yr, 9 male, 5 female; body mass index (BMI) 23.5 ± 2.3 kg/m2], middle-aged [M: 49.5 ± 3.7 yr, 10 male, 10 female; BMI 26.7 ± 3.0 kg/m2], and older [O: 69.6 ± 3.2 yr, 10 male, 7 female; BMI 26.9 ± 1.9 kg/m2] individuals. All subjects were initially screened by means of a medical questionnaire, physical examination, and resting ECG with exclusions for overt muscle wasting (>2 SD below age norms) (4), metabolic, respiratory or cardiovascular disorders, or other signs and symptoms of ill-health. All subjects had normal blood chemistry, were normotensive (blood pressure < 140/90) and were not prescribed medication. All subjects performed activities of daily living and recreation but did not routinely participate in moderate- to high-intensity aerobic exercise and none had participated in RET in the last 2 yr. At least 1 wk before the first acute study the subjects' 1 repetition maximum (1-RM) for leg extension on their dominant leg was measured (ISO Leg Extension, Leisure Lines, Leicestershire, UK). All subjects gave their written, informed consent to participate after all procedures and risks were explained. This study was approved by The University of Nottingham Ethics Committee and complied with the Declaration of Helsinki.
Acute Studies (Before and After Training)
Subjects were instructed to refrain from exercise 72 h days prior to each study day and from alcohol and caffeine for 24 h. Subjects fasted from 2100 the night before (water ad libitum) and reported to the laboratory at 0800. Body composition was measured by dual-energy X-ray absorptiometry (DXA; Lunar Prodigy II, GE Medical Systems) before and after the 20 wk RET; leg composition was measured on the dominant leg as the area inferior to the lowest visible point of the coccyx.
BASAL measurement phase.
After 70 min lying supine, measurements of LBF (femoral artery) were made intermittently from both legs for 40 min, with simultaneous measurements of blood pressure (BP) and heart rate (HR), designated as BASAL. A mean value from three measurements on each leg was used to obtain the basal value with no significant differences between the three measurements or between the legs. LBF was measured using the Doppler ultrasound technique (Toshiba Nemio-17). All measurements were taken with the subject supine, with no visual or aural stimuli. A single 5-MHz frequency probe was used to measure mean blood velocity (MBV) and arterial lumen diameter in the common femoral arteries of both legs. Measurements were made 2–3 cm proximal to the bifurcation of the femoral artery to minimize the effect of turbulence; the insonation angle was <60°. Arterial lumen diameter (mm) was measured by video calipers for each measurement and defined as the maximum distance between the media-adventitia interface of the near wall and the lumen-intima interface of the far wall of the vessel. LBF (l/min) was calculated as {MBV (cm/s) × π × [femoral artery radius (mm)]2}/1,000 × 60. Using the Doppler ultrasound technique to measure basal LBF we found a coefficient of variation of 9% for three independent measures under each condition assessed, suggesting that we could reliably detect changes of ∼18% of the basal value. When data were normalized for lean leg mass the results were identical to the nonnormalized data presented.
FED/FEDEX measurement phases.
At 120 min the subjects performed 6 × 8 repetitions of full-cycle unilateral leg extensions at 75% 1-RM on a free-standing machine (ISO Leg Extension, Leisure Lines). Immediately after exercise the subjects received, over 2 h, an oral-feed (Fortisip, Nutricia Clinical Care, Wiltshire, UK) which supplied energy at 4.25 times basal metabolic rate (BMR), as calculated by standard equations (17). The feed had a composition similar to that of a normal mixed-meal (16% protein, 49% carbohydrate, and 35% fat) and was given as a priming bolus (3 doses immediately after exercise), with four further doses every 30 min thereafter. Doses were between 61 and 96 ml, based on subject body weight to provide 6.5 kJ·kg body wt−1·30 min−1. BP, HR, and LBF were measured at 100, 120, and 140 min postexercise. LBF measurements were made from both legs alternately (providing data for the effects of FED and FEDEX) with the mean value of these three measurements used to provide LBF values for responses to feeding and to exercise plus feeding. Blood flows were stable throughout the measurement period, i.e., at 100, 120, and 140 min after exercise. This protocol was repeated at least 3 days, but less than 7 days after the subjects last training bout at the end of the supervised 20 wk whole body RET regime (Fig. 1). This allowed us to study the effects of RET rather than any remaining acute effects of a single exercise session.
The fully supervised RET program was designed to achieve skeletal muscle hypertrophy and improvements in strength, based on previously published recommendations for exercise intensity and duration (29). Subjects trained three times per week, with each session lasting ∼60 min. During 4 wk of induction training (to ensure adoption and adherence to correct technique), intensity was increased from 40% to 60% 1-RM. For the remaining 16 wk of training intensity was set at 70% 1-RM, with multiple sets of 12 repetitions and 2 min rest between sets. The same number of repetitions (16 sets of 12 repetitions) were performed each session over a total of 8 exercises; seated chest press, latissimus-pull down, seated lever row, leg extension, leg curl, leg press, back extension, and abdominal curl. One-RM assessments were made every 4 wk to ensure that the intensity of training was constant, i.e., 70% 1-RM, to account for strength improvements. Subjects were excluded from the study for noncompliance, defined as nonattendance for >6 consecutive sessions, less than 75% attendance, or failure to complete the set exercise regime on >15% attendance. Muscle strength was determined every 4 wk by the 1-RM assessments performed on six of the eight machines used during the training. Whole body strength was determined by the sum of force produced by three lower body exercises: leg extension, leg curl, and leg press; and three upper body exercises: latissimus-pull down, lever seated row, and seated chest press with newtons calculated as weight lifted × 9.807 based on a standard gravitational field.
MAP, HR, and LVC
Heart rate, and systolic and diastolic blood pressures were measured using an OMRON (OMRON Healthcare) automated blood pressure monitor and were recorded as the mean of three measurements. Mean arterial blood pressure (MAP), calculated as (2/3 diastolic blood pressure) + (1/3 systolic blood pressure) was measured to calculate leg vascular conductance (LVC) as LVC (l·min−1·100 mmHg−1) = LBF (l/min-1)/MAP × 100.
Statistical Analyses
Statistical analyses were performed using GraphPad Prism Version 5.00 (La Jolla, CA). All data are reported as means ± SE with significance set at P < 0.05. Repeated-measures ANOVA and Bonferroni post hoc analysis were used to compare pre- and posttraining strength and blood flow values. Pearson's correlation was used to explore relationships between age and blood flow responses to feeding and to exercise plus feeding.
Body Composition
Before training there were no significant differences in whole body or dominant whole leg lean mass between the young, middle-aged, and older groups as assessed by DXA (Table 1). This remained true after RET. Nevertheless, there were significant increases in whole body lean mass after the RET regime in the young and middle-aged subjects (young, +5.0 ± 1.1%, P < 0.001; middle-aged, +1.7 ± 0.8%, P < 0.05) and increases in whole leg lean mass in the young subjects (+4.3 ± 1.4%, P < 0.01).
Measures of Muscle Strength
All three age groups showed significant increases in muscle strength after RET. Before training, the muscle strength (the sum of the 6 previously mentioned exercises) of the young (5,729 ± 405 N) was higher than that of the middle-aged (4,921 ± 387 N), both of which were higher than that of the older individuals (4,082 ± 202 N, P < 0.01) (Table 1). All three groups showed similar strength gains, with the young increasing from 5,729 ± 405 to 7,609 ± 377 N (+36%), middle-aged from 4,921 ± 387 to 6,535 ± 460 N (+35%), and old from 4,082 ± 282 to 5,630 ± 374 N (+39%). The 39% strength increase in the older group took their mean strength to a value similar to that in the young before training (5,630 vs. 5,729 N).
Measures of LBF
Using the Doppler ultrasound technique to measure basal LBF we found a coefficient of variation of 9% for three independent measures under each condition assessed, suggesting that we could reliably detect changes of ∼18% of the basal value. When data were normalized for lean leg mass the results were identical to the nonnormalized data presented.
LBF under BASAL, FED, and FEDEX conditions before and after RET.
Before and after RET there were no differences in BASAL LBF between the age groups (Fig. 2). Before RET, only the young group demonstrated increased FED LBF (P < 0.01) and only the young and middle-aged groups demonstrated increased FEDEX LBF (P < 0.001). After RET, both the young and middle-aged groups increased FED LBF (P < 0.01) and all groups increased LBF in response to FEDEX (Y: +78.4 ± 10.3%, P < 0.001; M: +95.7 ± 14.6%, P < 0.001; O: +79.8 ± 19.0%, P < 0.001), displaying LBF values significantly higher after FEDEX than after FED alone (P < 0.001) (Fig. 2). Adopting (AGE × LBF) correlation analyses we found that before RET, both FED (Fig. 3A) and FEDEX LBF responses were blunted with increasing age (Fig. 3B), but these age-related decreases were no longer apparent after RET (Fig. 3, C and D).
Measures of LVC
Relationships between BASAL LVC and age.
BASAL LVC was significantly greater in the young than in the old before RET (0.56 ± 0.06 vs. 0.36 ± 0.03 l·min−1·100 mmHg−1, P < 0.01). After RET, BASAL LVC in the older group was significantly increased (0.36 ± 0.03 vs. 0.47 ± 0.04 l·min−1·100 mmHg−1, P < 0.001), and there was a trend for it to also increase in the middle-aged group (0.43 ± 0.05 vs. 0.50 ± 0.04 l·min−1·100 mmHg−1, P = 0.095). After RET there were no significant differences in BASAL LVC between the age groups (Y: 0.63 ± 0.06; M: 0.50 ± 0.04; O: 0.47 ± 0.04 l·min−1·100 mmHg−1) (Fig. 4).
LVC under BASAL, FED, and FEDEX conditions before and after RET.
BASAL LVC was significantly greater in the middle-aged and older groups after RET (M: 0.53 ± 0.04 vs. 0.67 ± 0.04; O: 0.41 ± 0.05 vs. 0.55 ± 0.06 l·min−1·100 mmHg−1, both P < 0.05). Before RET only in the young was there an increase in FED LVC (0.56 ± 0.06 vs. 0.78 ± 0.10 l·min−1·100 mmHg−1, P < 0.01), whereas after RET the young (0.63 ± 0.06 vs. 0.86 ± 0.08 l·min−1·100 mmHg−1, P < 0.001) and the middle-aged groups (0.50 ± 0.04 vs. 0.67 ± 0.04 l·min−1·100 mmHg−1, P < 0.01) increased. All three age groups increased LVC with FEDEX both before RET (Y: 0.56 ± 0.06 vs. 0.98 ± 0.09, P < 0.001; M: 0.43 ± 0.05 vs. 0.77 ± 0.05, P < 0.001; O: 0.36 ± 0.03 vs. 0.50 ± 0.04 l·min−1·100 mmHg−1, P < 0.05) and after RET (Y: 0.63 ± 0.06 vs. 1.12 ± 0.09; M: 0.50 ± 0.04 vs. 0.89 ± 0.05; O: 0.47 ± 0.04 vs. 0.81 ± 0.08 l·min−1·100 mmHg−1, all P < 0.001). The increase in the old was significantly greater after RET (49 ± 11 vs. 80 ± 19%, P < 0.01) such that FEDEX LVC in the old after RET was not different from that of the young before RET, effectively restoring LVC responses in the old to those typical of younger subjects (Fig. 4).
In summary we report that age-related declines in FED and FEDEX (but not BASAL) LBF are ameliorated by RET, which is concomitant with a restoration of LVC. We are the first to report that age-related dysregulation in LBF under FED and FEDEX conditions (along with associated diminutions in LVC) may be ameliorated by RET. Although we were unable to seek a mechanism for our findings in this large cohort, it is evident that RET may in some cases reverse age-related declines in leg LBF/LVC, which are indicative of pathological changes in vessel structure and/or vascular tone.
Our findings in terms of BASAL LBF are consistent with previous reports of age-related declines in untrained older humans (11) that are unrelated to muscle mass (lean mass was similar between our older and younger groups). Thus other mechanisms such as chronic vasoconstriction due to increased α-adrenergic tone and/or a lower O2 demand (12, 37) are more likely candidates than lower muscle mass (i.e., sarcopenia) per se. Although RET is expected to cause muscle hypertrophy, somewhat surprisingly [given the common view of such vascular adaptations being specific to endurance training (35)], it has also been shown to increase BASAL LBF (1, 34). For example, Tanimoto and colleagues reported that 13 wk of high (85–90% 1-RM)- or low-intensity (50–60% 1-RM) RET was equally effective in increasing BASAL LBF (34), and it is well established from cross-sectional studies that LBF in RET individuals is better preserved with ageing (22). It would therefore have been expected that age-related declines in BASAL LBF may be ameliorated by RET. Nonetheless, our data do not support this as we found no increase in BASAL LBF after RET in any age group; moreover when all our data were expressed relative to age and/or lean leg mass, declines in postabsorptive LBF with advancing age were still evident even after RET. This is reflected by the fact that increases in LVC in older subjects after RET were principally due to decreases in MAP (rather than increases in LBF), which we speculate may have been due to an amelioration of increased sympathetic nerve activity directed to muscle vascular beds that has been reported in ageing (24). Finally, as no groups demonstrated increased BASAL LBF after RET despite displaying hypertrophy, this further supports the prior notion of dissociation between muscle mass and LBF per se (11).
There is little published information concerning acute responses in LBF to FED. Fugmann et al. (14) showed a long lasting (>2 h) increase in peripheral blood flow in response to feeding using venous capacitance plethysmography, as did Hernandez et al. (18), to the magnitude of 16–25%, although the method used in the latter study (indocyanine green dye dilution) is inherently more variable than either plethysmographic or Doppler techniques. Coupling the use of Doppler and contrast enhanced ultrasound (CEUS), Vincent et al. (37) reported a 33% increase in brachial artery blood flow, (similar to the 40% increase in FED LBF we observed in the young before RET) and a 50% increase in forearm muscle microvascular blood volume 60 min after a mixed meal [2,008 kJ, 68% carbohydate, 16% fat, and 17% protein (37)]. In line with these findings, we found that LBF increased in response to FED in our younger subjects. Moreover, this increase was not apparent in our middle-aged or older subjects and further age × LBF correlation analyses confirmed age-related declines in LBF responses to FED, a relationship also found by others (31). Collectively these data signify a physiological increase in FED LBF that is diminished with age. Intriguingly, RET improved these diminutions such that FED LBF responses increased significantly in the middle-aged and older groups (when compared with their pretraining values) and the negative relationship between increasing age and FED LBF responses was ameliorated, presumably via enhancement of FED LVC. Thus, although we were unable to uncover specific mechanisms at this time, these data highlight that RET can reverse declines in FED LBF responses in ageing. Furthermore, we speculate that as the vast majority of LBF goes to skeletal muscles, improved LBF and LVC after RET may positively impact age-related declines in glucose disposal (14, 20) and amino acid deposition; clearly this conjecture warrants further investigation.
Exercise hyperemia is evident in active muscles both during and for sustained periods afterward and is important for performance and ensuing recovery and remodeling alike (30). Importantly, such hyperemic responses also seem to be diminished in ageing (13, 25), which may contribute to reduced performance and maladaptation to exercise training in older age (16). In the present study we elected to measure LBF during the recovery period from exercise, which reflects the "remodeling" period [e.g., where muscle protein turnover is heightened (19)]. We also chose to study the combined effects of exercise and feeding (rather than exercise hyperemia per se) to maximize practical ramifications of the work. For instance, practicably most people would (or be recommended to) combine resistance exercise with feeding to maximize muscle anabolic responses (23). It is therefore of significance that RET abolished blunted LBF responses to FEDEX seen before RET in both the middle-aged and older subjects. In young healthy men RET reportedly increased peak limb vasodilatory capacity (26), which raises the possibility that decreased arteriolar tone could contribute to the increased capacity for higher LBF after RET. Thus decreased α-adrenergic tone [known to be elevated in older individuals (12, 32)] and perhaps improved redistribution of LBF to working muscles (i.e., improved functional sympatholysis) are attractive possibilities to contribute to improvements in LBF and corresponding normalization of LVC in response to FEDEX.
In conclusion, RET rejuvenates age-related declines in LVC and LBF under FED and FEDEX conditions, which symbolizes improved peripheral LBF and LVC and suggests that vascular adaptation represents a key facet in the metabolic benefits of RET. Although we have studied "healthy" subjects, it is speculated that improved LBF and LVC with RET may also benefit those with cardiovascular or metabolic conditions (2).
Study Limitations
We acknowledge there are limitations to our elected study design. First our measures under FED and FEDEX conditions precluded inclusion of an exercise-only condition. Second, although the unilateral exercise model provides a good model to investigate how whole body RET has modulated peripheral blood flow as tissue perfusion is closely matched with demand, we accept that it is possible that our results may not have arisen from isolated lower-limb RET (i.e., which may not have affected MAP) and that performing acute whole body rather than unilateral leg exercise prior to measurements could have influenced our "acute" findings. Third, the large subject number and diverse age groups negated the option to include a time control group (both for practicable and cost reasons). Finally, it should be noted that some of our positive results in LVC (i.e., increases in BASAL LVC) were based on proportionally greater reductions in MAP, rather than increases in LBF, although this was not the case in other conditions (i.e., LVC under FEDEX conditions in older individuals).
We thank the Biotechnology and Biological Sciences Research Council (BBSRC) (BB/X510697/1 and BB/C516779/1) and the EC EXEGENESIS program.
No conflicts of interest, financial or otherwise, are declared by the author(s).
B.P., J.W., P.J.A., W.H., and D.R. performed experiments; B.P., P.J.A., and K.S. analyzed data; B.P., J.W., P.J.A., and K.S. interpreted results of experiments; B.P. prepared figures; B.P. and M.R. drafted manuscript; B.P., J.W., P.J.A., K.S., P.L.G., I.A.M., and M.R. designed studies and edited and revised.
We are grateful to all our subjects and to M. Baker and A. Gates for technical assistance.
- Copyright © 2012 the American Physiological Society


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Columbia Optima TSS Toilet & Shower System
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CMSC 414 Computer and Network Security Lecture 9. Jonathan Katz. Midterm exam…. This Thursday Open notes/book/etc All you should need are your notes Printouts of case studies might be helpful, but not necessary if you have read/understand them. (HW2 is out). Security policy.
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Jonathan Katz


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Bogus Good Samaritan helps elderly couple moments after stealing from their luggage
THIS is the moment a man pretending to be a Good Samaritan helped an elderly couple with their luggage just after stealing from their suitcases.
The thief was caught on camera going through a 73-year-old grandfather's luggage and stole their MEDICATION as he waited for a train to go on holiday.
The crook went through their items and even tried on the pensioners clothes - but when they returned he offered to "help" them carry in onto a carriage.
The criminal also stole a newly purchased camera, a jacket and a bag while were meant for the elderly couple's holiday.
PC Steve Lawrence from the British Transport Police said: "This was an extremely upsetting experience for the couple and one of the worst possible starts to their holiday.
"At a time when they should have been eagerly looking forward to their break, they were instead made to feel vulnerable as a result of this callous theft.
"The most galling aspect of this incident is the fact that just moments after ransacking their bags, the brazen thief had the nerve to help the couple onto the train with their luggage and walking stick."
This was an extremely upsetting experience for the couple and one of the worst possible starts to their holiday
Police yesterday released pictures and footage of the theft which happened when the grandfather left his luggage unattended to meet his wife.
The thief is thought to have got off a train at Troedyrhiw station near Merthyr Tydfil, South Wales and seen the bag without its owner.
He is described as a caucasian male around 20-years-old who is approximately 5ft 10in to 6ft tall and of thin build with collar length dark hair.
The thief was wearing black clothing and a black baseball hat with a white motif on the front and a white cross on top during the incident on July 11.
Pc Lawrence added: "Enquiries have been ongoing to identify the person responsible for this theft but to no avail. "However, today, I am in a position to release an image of a man we believe will have key information about this incident.
"I would urge anyone who recognises the individual pictured, or knows their whereabouts, to please get in touch.
• Anyone with information should contact British Transport Police on 0800 40 50 40.


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Holly Carpenter: 'Creeps on Snapchat need to stop contacting me'
Model Holly Carpenter may be enjoying the single life - but it seems she's been attracting some unwanted male attention.
The beauty queen (23, right) is known for her love of picture-sharing app Snapchat, but it looks like some of her male followers are a little too eager to impress the pretty brunette by sending X-rated snaps - something Holly is less than happy about.
"'Yeah, I've never met him but he just sent me a [explicit] pic and now I really fancy him' said no woman ever. Creeps on Snapchat need to stop," the Raheny native tweeted.
Inappropriate photos from male admirers aside, Holly recently told the Diary she couldn't be happier being single.
The former Britain's Next Top Model contestant spent her summer on the festival circuit with her close girlfriends and was spotted partying at Forbidden Fruit, Longitude and Electric Picnic.
"I'm only 23, so all my friends are single and we're just a group of girls having so much fun, so it's nice," she said.