text:
|Publication number
|Publication type
|Application number
|Publication date
|Feb 18, 2003
|Filing date
|Oct 19, 2000
|Priority date
|Oct 19, 2000
|Fee status
|Also published as
|Publication number
|Herbert L. Berman, Jeffrey N. Roe, Robert N. Blair
|Original Assignee
|Medoptix, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (38), Non-Patent Citations (14), Referenced by (53), Classifications (25), Legal Events (6)
|External Links: USPTO, USPTO Assignment, Espacenet
This invention involves non-invasive glucose measurement and a process for determining blood glucose levels in the human body. Preferably, the process is used on a fingertip or other part of the body, typically a skin surface of the body.
The American Diabetes Association reports that nearly 6% of the population in the United States, a group of 16 million people, has diabetes. The Association further reports that diabetes is the seventh leading cause of death in the United States, contributing to nearly 200,000 deaths per year. Diabetes is a chronic disease having no cure. The complications of the disease include blindness, kidney disease, nerve disease, and heart disease, perhaps with stroke. Diabetes is said to be the leading cause of new cases of blindness in individuals in the range of ages between 20 and 74; from 12,000-24,000 people per year lose their sight because of diabetes. Diabetes is the leading cause of end-stage renal disease, accounting for nearly 40% of new cases. Nearly 60-70% of people with diabetes have mild to severe forms of diabetic nerve damage which, in severe forms, can lead to lower limb amputations. People with diabetes are 2-4 times more likely to have heart disease and to suffer strokes.
Diabetes is a disease in which the body does not produce or properly use insulin, a hormone needed to convert sugar, starches, and the like into energy. Although the cause of diabetes is not completely understood, genetics, environmental factors, and viral causes have been partially identified.
There are two major types of diabetes: Type I and Type II. Type I diabetes (formerly known as juvenile diabetes) is an autoimmune disease in which the body does not produce any insulin and most often occurs in young adults and children. People with Type I diabetes must take daily insulin injections to stay alive.
Type II diabetes is a metabolic disorder resulting from the body's inability to make enough, or properly to use, insulin. Type II diabetes accounts for 90-95% of diabetes. In the United States, Type II diabetes is nearing epidemic proportions, principally due to an increased number of older Americans and a greater prevalence of obesity and a sedentary lifestyle.
Insulin, in simple terms, is the hormone that unlocks the cells of the body, allowing glucose to enter those cells and feed them. Since, in diabetics, glucose cannot enter the cells, the glucose builds up in the blood and the body's cells literally starve to death.
Diabetics having Type I diabetes typically are required to self-administer insulin using, e.g., a syringe or a pin with needle and cartridge. Continuous subcutaneous insulin infusion via implanted pumps is also available. Insulin itself is typically obtained from pork pancreas or is made chemically identical to human insulin by recombinant DNA technology or by chemical modification of pork insulin. Although there are a variety of different insulins for rapid-, short-, intermediate-, and long-acting forms that may be used variously, separately or mixed in the same syringe, use of insulin for treatment of diabetes is not to be ignored.
It is highly recommended by the medical profession that insulin-using patients practice self-monitoring of blood glucose (SMBG). Based upon the level of glucose in the blood, individuals may make insulin dosage adjustments before injection. Adjustments are necessary since blood glucose levels vary day to day for a variety of reasons, e.g., exercise, stress, rates of food absorption, types of food, hormonal changes (pregnancy, puberty, etc.) and the like. Despite the importance of SMBG, several studies have found that the proportion of individuals who self-monitor at least once a day significantly declines with age. This decrease is likely due simply to the fact that the typical, most widely used, method of SMBG involves obtaining blood from a finger stick. Many patients consider obtaining blood to be significantly more painful than the self-administration of insulin.
There is a desire for a less invasive method of glucose measurement. Methods exist or are being developed for a minimally invasive glucose monitoring, which use body fluids other than blood (e.g., sweat or saliva), subcutaneous tissue, or blood measured less invasively. Sweat and saliva are relatively easy to obtain, but their glucose concentration appears to lag in time significantly behind that of blood glucose. Measures to increase sweating have been developed and seem to increase the timeliness of the sweat glucose measurement, however.
Subcutaneous glucose measurements seem to lag only a few minutes behind directly measured blood glucose and may actually be a better measurement of the critical values of glucose concentrations in the brain, muscle, and in other tissue. Glucose may be measured by non-invasive or minimally-invasive techniques, such as those making the skin or mucous membranes permeable to glucose or those placing a reporter molecule in the subcutaneous tissue. Needle-type sensors have been improved in accuracy, size, and stability and may be placed in the subcutaneous tissue or peripheral veins to monitor blood glucose with small instruments. See, "An Overview of Minimally Invasive Technologies", Clin. Chem. September 1992; 38(9):1596-1600.
Truly simple, non-invasive methods of measuring glucose are not commercially available.
This invention involves non-invasive glucose measurement and a process for determining blood glucose levels in the human body upon achieving a static level of glucose at a skin surface over a period of time.
Processes which are able to assess glucose concentrations predictably from a skin surface may include a step of extracting a sample from the skin and then measuring that sample from the skin. Such sample extraction processes may include suction blister extraction, wick extraction, microdialysis extraction, iontophoretic extraction, sontophoretic extraction, and chemically enhanced extraction. Aside from the extraction processes, non-invasive measurement processes may include electrochemical sensors (e.g., glucose electrodes), optochemical sensors (e.g., colorimetric strips), near-infrared spectroscopy (NIR), mid-infrared spectroscopy (MIR), infrared spectroscopy (IR), Raman spectroscopy, photoacoustic spectroscopy, measurement of refractive index or scatter changes, fluorescent spectroscopy, and polarization spectroscopy.
The processes for extraction and measurement are illustrative and are not meant to be an exclusive list.
FIG. 1 shows a graph representing a glucose level rising sharply and reaching a static value.
FIG. 2 shows a graph correlating glucose levels measured using a specific variation of the device with glucose levels in the blood determined using a commercial device.
FIG. 3 shows a pair of glucose IR curves (taken before and after eating) for an individual having diabetes made using the inventive glucose measuring device.
FIG. 4 shows a graph comparing glucose levels in a non-diabetic individual (taken before and after eating) made using the inventive glucose measuring device and direct blood measurement. This graph shows that the inventive procedure tracks blood glucose levels with minimum time lag.
In non-invasively measuring analyte levels using mid-infrared ("MIR"), particularly using a device and methods as described in U.S. patent application Ser. No. 09/547,433, filed Apr. 12, 2000, entitled "INFRARED ATR GLUCOSE MEASUREMENT SYSTEM (II)", which is herein incorporated by reference in its entirety, penetration of skin by IR ranged in only a few micrometers. Thus, because of this small penetration depth, the described device may have been measuring glucose from the mixture of oils and sweat that is pumped to the skin surface. Therefore, multiple alternative processes may be utilized in non-invasively measuring analytes, particularly glucose, from a skin surface.
The device in co-pending application Ser. No. 09/547,433 described the use of IR attenuated total reflectance ("ATR") spectroscopy to detect and ultimately to determine the level of a selected analyte, preferably blood glucose, in the human body. Preferably, the inventive device used an ATR procedure in which the size and configuration of the crystal permits a number of internal reflections before the beam is allowed to exit the crystal with its measured information.
We have found that the mid-IR spectrum does not penetrate into the skin to an appreciable level. Specifically, the skin is made up of a number of layers: the outermost—the stratum corneum—is a layer substantially free of interference from cholesterol, water, gamma globulin, albumin, and blood. It is a shallow outer region covering the stratum granulosum, the stratum spinosum, and the basal layer. The area between the basal layer to the outside is not vascularized. It is unlikely that any layer other than the stratum corneum is traversed by the mid-IR light involved in this inventive device. Although we do not wish to be bound by theory, it is likely that the eccrine or sweat glands transport the glucose to the outer skin layers for measurement and analysis by our inventions.
We have surprisingly found that a glucose measuring device made according to the invention in application Ser. No. 09/547,433 is quite effective on the human skin of the hands and fingers. We have found that the glucose concentration as measured by the inventive devices correlates very closely with the glucose concentration determined by a direct determination from a blood sample. This is surprising in that the IR beam likely passes into the skin, i.e., the stratum corneum, for only a few microns. It is unlikely in a fingertip that any blood is crossed by that light path. As discussed above, the stratum corneum is the outer layer of skin and is substantially unvascularized. The stratum corneum is the final outer product of epidermal differentiation or keratinization. It is made up of a number of closely packed layers of flattened polyhedral corneocytes (also known as squames). These cells overlap and interlock with neighboring cells by ridges and grooves. In the thin skin of the human body, this layer may be only a few cells deep, but in thicker skin, such as may be found on the toes and feet, it may be more than 50 cells deep. The plasma membrane of the corneocyte appears thickened compared with that of keratinocytes in the lower layers of the skin, but this apparent deposition of a dense marginal band formed by stabilization of a soluble precursor, involucrin, just below the stratum corneum.
It is sometimes necessary to clean the skin exterior prior before sampling to remove extraneous glucose from the skin surface. At least when using IR spectra to measure glucose, it is important to select cleaning materials having IR spectra that do not interfere with the IR spectra of glucose. We consider a kit of the following to be suitable for preparation of the sample skin for the testing. The components are: a.) a glucose solvent, e.g., water or other highly polar solvent; b.) a solvent for removing the water, e.g., isopropanol, and c.) a skin softener or pliability enhancer not having significant IR peaks in the noted IR regions, e.g., mineral oils such as those sold as "Nujol". Preferably the b.) and c.) components are admixed, although they need not be. Certain mixtures of the first two components may be acceptable, but only if the sampling situation is such that the solvents evaporate without IR spectrographically significant residue. We have also found that soap and its residue are sometimes a problem. Consequently, addition of a weak acid again not having significant IR peaks in the noted IR regions, to the a.) component, i.e., the solvent for removing glucose, is desirable. The preferred weak acid is boric acid. The inventive kit preferably is made up of sealed packets of the components, most preferably each packet containing an absorbent pad.
Method of Use
As noted in application Ser. No. 09/547,433, for IR measurement, it is desirable both to clean the plate before use and to clean the exterior surface of the skin to be sampled. Again, we have found that the exterior skin is highly loaded with glucose that is easily removed preferably by using the skin preparation kit, or, less preferably, by washing the skin. Reproducible and accurate glucose measurements may then be had in a period as short as one to ten minutes, generally less than five minutes, after cleaning the area of the skin to be measured.
We also note that, depending upon the design of a specific variation of a device made according to the invention, periodic at least an initial calibration of the device, using typical blood sample glucose determinations, may be necessary or desirable.
Alternate Methods of Use
We have also observed the following phenomena. In attempting to measure glucose using the mid IR apparatus described above, we noted that by using a solvent on the surface which dissolved glucose, our procedures showed that the glucose level at the skin was substantially lowered, if not eliminated. However, as is shown in the examples, shortly thereafter, the glucose level began to rise sharply and consequently would reach static value which was correlateable in a consistent fashion to a glucose level found in the blood.
As shown in FIG. 1, the curve representing the glucose level rises sharply and eventually plateaus over a time period, T. This glucose level may be measured by any of the devices and processes as discussed in application Ser. No. 09/547,433 or herein at predetermined time periods, ΔT, until the glucose level reaches a substantially static value, thus representing the glucose level in the blood. As we have noted above, the outer layer of the skin is not vascularized and the physiological source of the glucose transport to the skin surface is not all together clear. Nevertheless, it is easily assessable and quite repeatable. Our method of using mid IR to measure this glucose level is believed, on basic principals, only to penetrate the skin at best a few microns. Other procedures which are non-invasive and which are able to assess glucose concentration upon this achievement of glucose stasis level are similarly and predictably able to assess the glucose level in the human body.
Such alternative procedures may provide for extracting a sample from the skin and then measuring the analyte, or glucose, level in the sample. Potential extraction methods may include blister suction and wick extraction, microdialysis extraction, iontophoretic extraction, sontophoretic extraction, and chemically enhanced extraction.
Sample measurement methods may include electrochemical sensors (e.g., glucose electrodes), optochemical sensors (e.g., colorimetric strips), near-infrared spectroscopy (NIR), infrared spectroscopy (IR), Raman spectroscopy, photoacoustic spectroscopy, measurement of refractive index or scatter changes, fluorescent spectroscopy, and polarization spectroscopy. These methods of sample extraction and measurement are provided.
Glucose Extraction
Blister suction and wick extraction are some of the most common methods for sampling subcutaneous interstitial tissue fluid, although blister extraction is less invasive than the wick extraction technique. Microdialysis extraction involves calculating the concentrations of compounds, including skin glucose concentrations, which are in the extracellular water space. Microdialysis has been applied to peripheral tissue types, e.g., skin, muscle, adipose, eye, lung, liver, and blood as well as having microdialysis probes implanted subcutaneously and perfused by a portable microinfusion pump. Finally, iontophoretic extraction involves noninvasive glucose measurement from subcutaneous tissue.
Glucose Measurement
Electrochemical Sensors
Electrochemical sensors (e.g., glucose electrodes) utilize electrical signal as a direct consequence of some (chemical) process occurring at a transducer/analyte interface. Some implantable glucose sensors may include electrocatalytic sensors, which are based on direct electro-oxidation of glucose on noble metal electrodes, and biosensors, which combine glucose-specific enzymes with electrochemical electrodes.
Such sensors may be fabricated by combining biologically active components (e.g., enzymes, antibodies, cells, tissues or microorganisms) with some physical transducer. Biosensors may be direct enzyme biosensors or affinity sensors based on enzyme labeled immunoassays. Enzymes may be used as a molecular recognition element in glucose sensing while immunoassays may provide the ability to sense extremely low amounts of an ahalyte. Electrochemical sensors may also include piezoelectric, thermoelectric, and acoustic sensors used for glucose measurement by utilizing an enzyme-catalysed reaction to create a measurable change in a physical parameter detectable by a transducer.
Optochemical Sensors
Optochemical sensors (e.g., colorimetric strips) are based on changes in some optical parameter due to enzyme reactions or antibody-antigen bonding at a transducer interface. Such sensors may include enzyme optrodes and optical immunosensors and may also include different monitoring processes such as densitometric, refractometric or calorimetric devices.
Electrochemical biosensors may be constructed on the amperometric principle which is based on the oxidation or reduction of electrochemically active substances. Such sensor may also be constructed to measure the changes in local pH due to the gluconic acid produced at a potentiometric sensor, usually a coated wire pH-selective electrode or an ion selective field effect transistor (ISFET). Also, electrical resistance changes during the overall process may be used as a basis for conductometric biosensors.
Moreover, potentiometric glucose sensors (e.g., coated wire sensors) may potentially be utilized for implantable use. Coated wire sensors are general easy to fabricate and are suitable for miniaturization to diameters of 50-200 μm. They may also be used in combination with a standard cardiographic (EKG) reference electrode.
Near-Infrared Spectroscopy (NIR)
The NIR region of the spectrum extends from 700 to 2500 nm (14,000-4000 cm−). In this region, absorption bands are due to overtone vibrations of anharmonic fundamental absorption bands to combinations of fundamental absorption bands primarily associated with C—H; O—H, and N—H stretching vibrations. For overtone vibrations, only the first, second, and third overtones are usually seen with the magnitude of the absorption peak diminishing substantially with overtone order. The NIR region may be attractive for quantitative spectroscopy since NIR instrumentation is readily available.
In measuring aqueous glucose, the NIR region which lies between 2.0 and 2.5 μm may be utilized. This region contains a relative minimum in the water absorption spectrum and has readily identifiable glucose peak information. However, NIR spectra may generally be sensitive to a host of factors including temperature, pH, and scattering.
Raman Spectroscopy
Raman spectra are typically observed when incident light at a frequency v0=c/λ0 is inelastically scattered at frequencies v0Īvi. The loss (Stokes shift) or gain (anti-Stokes shift) of photon energy, and hence frequency, is due to transitions of the rotational and vibrational energy states within the scattering molecule. Since the Raman spectrum is independent of excitation frequency, an excitation frequency may be chosen which is appropriate for a particular sample. However, a drawback may be that scatter and reabsorption in biological tissues may make detection of Raman shifts due to physiological concentrations difficult.
Photoacoustic Laser Spectroscopy
Photoacoustic laser spectroscopy has been utilized for measuring glucose concentrations of human whole blood samples using pulsed laser photoacoustic spectroscopy. Such a process may use, e.g., a CO2 laser operating with μJ pulse energy, to measure tiny changes of the absorption coefficient of the sample caused by the variations of blood glucose concentrations.
Refractive Index or Scatter Changes
Measurement of refractive index or scatter changes may be feasible to measure blood glucose by measuring the scattering coefficient of human skin, e.g., by using optical sensors attached to the skin. Such techniques may be based on the fact that the refractive index of sugar solution changes with the concentration of sugar.
Fluorescent Spectroscopy
There may be two categories for fluorescent spectroscopy: glucose-oxidase based sensors and affinity-binding sensors. Sensors in the first category may use the electroenzymatic oxidation of glucose by glucose-oxidase (GOX) in order to generate an optically detectable glucose-dependent signal. The oxidation of glucose and oxygen forms gluconolactone and hydrogen peroxide.
Several methods for optically detecting the products of this reaction, and hence the concentration of glucose driving the reaction, may be utilized. Since oxygen is consumed in this reaction at a rate dependent on the local concentration of glucose, a fluorophore which is sensitive to local oxygen concentration can also be used to quantify glucose concentration.
A method GOX based fluorescent sensor involves the redox mediator tetrathiafulvalene (TTF) whose oxidized form TTF+ reacts with the reduced form of GOX to reversibly form TTF0. Since TTF+ is absorbed in the 540-580 nm range, a method for quantifying the presence of TTF+ (and hence glucose driving the production of reduced GOX) is available.
Another method involves the hydrogen peroxide (H2O2) generated from the GOX reaction with glucose reacting with bis(2,4,6-trichlorophenyl) oxalate (TCPO) to form a peroxyoxylate. Here, the peroxyoxylate formed transfers chemiluminescent energy to an accepting fluorophore which in turn emits photons at a characteristic wavelength. The emission by the fluorophore is proportional to the glucose concentration and may be detected optically.
Polarization Spectroscopy
Polarimetric quantification of glucose may be based on the principle of optical rotary dispersion (ORD) where a chiral molecule in an aqueous solution rotates the plane of linearly polarized light passing through the solution. This rotation is due to a difference in the indices of refraction nL and nR for left- and right-circularly polarized light passing through a solution containing the molecule. Because the molecule has a chirality (or "handedness"), the angle of rotation depends linearly on the concentration of the chiral species, the path length through the sample, and a constant for the molecule called the specific rotation. Glucose in the body is dextrorotatory, i.e., rotates light in a right-handed direction, and has a specific rotation of +52.6į dm−1 (g/L)−1.
Using a commercially available IR spectrometer (Nicolet 510) having a ZnSe crystal ATR plate (55 mm long, 10 mm wide, and 4 mm thick) we tested the inventive procedure. We calibrated the output of the spectrometer by comparing the IR signal to the values actually measured using one of the inventor's blood samples. The inventor used a blood stick known as "Whisper Soft" by Amira Medical Co. and "Glucometer Elite" blood glucose test strips sold by Bayer Corp. of Elkhart, Ind. On each of the various test days, the inventor took several test sticks and measured the glucose value of the resulting blood; the IR test was made at the same approximate time.
As shown in the calibration curve of FIG. 2, the data are quite consistent. So, where the blood glucose concentration "B" is in (mg/dl) and "S" is the difference between the absorbance at the referencing region and the measuring region as measured by the spectrometer:
In accordance with a clinical protocol, a diabetic was then tested. Curve 1 in FIG. 3 shows the IR absorbance spectrum of the test subject's finger before eating (and after fasting overnight) and curve 2 shows IR absorbance spectrum of the same individual after having eaten. Incidentally, insulin was administered shortly after the measurement of curve 2.
In any event, the significant difference in the two peak heights at the 9.75 micrometer wavelength and the equality of the two IR absorbance values at the 8.50 micrometer value shows the effectiveness of the procedure in measuring glucose level.
That the inventive glucose monitoring device non-invasively determines blood glucose level and quickly follows changes in that blood glucose level is shown in FIG. 4. Using both the inventive procedure and a commercial glucose device, one of the inventors followed his glucose level for a single day. The blood sticks are considered to be accurate within 15% of the actual reading.
The results are shown in FIG. 4. Of particular interest is the measurement just before 4:40 pm wherein the two values are essentially the same. A high sugar candy bar was eaten at about 4:45pm and measurements of glucose level were taken using the inventive procedure at about 5:03, 5:18, 5:35 and 5:50. A blood sample was taken at 5:35 and reflected almost the same value as that measured using the inventive procedure. Consequently, the procedure tracks that measured by the blood very quickly.
This invention has been described and specific examples of the invention have been portrayed. The use of those specifics is not intended to limit the invention in any way. Additionally, to the extent there are variations of the invention with are within the spirit of the disclosure and yet are equivalent to the inventions found in the claims, it is our intent that this patent will cover those variations as well.
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|Sep 29, 2015
|Oct 4, 2016
|Zyomed Corp.
|Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing
|Jan 12, 2016
|Oct 4, 2016
|Zyomed Corp.
|Systems and methods for collision computing for detection and noninvasive measurement of blood glucose and other substances and events
|Jan 12, 2016
|Oct 4, 2016
|Zyomed, Corp.
|Systems and methods for generating and using projector curve sets for universal calibration for noninvasive blood glucose and other measurements
|Aug 11, 2016
|Jan 31, 2017
|Zyomed Corp.
|Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
|Sep 11, 2012
|Feb 14, 2017
|St. Louis Medical Devices, Inc.
|Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis
|Sep 11, 2012
|Feb 28, 2017
|St. Louis Medical Devices, Inc.
|Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis
|Aug 10, 2016
|Apr 4, 2017
|Zyomed Corp.
|Systems and methods for measurement of heart rate and other heart-related characteristics from photoplethysmographic (PPG) signals using collision computing
|Sep 11, 2012
|Apr 25, 2017
|St. Louis Medical Devices, Inc.
|Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis
|Sep 11, 2012
|Oct 17, 2017
|St. Louis Medical Devices, Inc.
|Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis
|Jul 3, 2002
|Feb 27, 2003
|Peter Rule
|Site selection for determining analyte concentration in living tissue
|Jan 2, 2003
|Jun 5, 2003
|Berman Herbert L.
|Glucose measurement utilizing non-invasive assessment methods
|May 9, 2003
|Nov 11, 2004
|Kouchnir Mikhail A.
|Non-invasive analyte measurement device having increased signal to noise ratios
|Jul 27, 2004
|Mar 31, 2005
|Peter Rule
|Sample adapter
|Nov 26, 2003
|Mar 31, 2005
|Cullum Brian M.
|Multiphoton photoacoustic spectroscopy system and method
|Dec 19, 2003
|Apr 28, 2005
|Ediger Marwood N.
|Determination of disease state using Raman Spectroscopy of tissue
|Feb 4, 2004
|Aug 4, 2005
|Medoptix, Inc.
|Integrated device for non-invasive analyte measurement
|Mar 6, 2005
|Sep 8, 2005
|Calisto Medical, Inc.
|Methods and devices for non-invasively measuring quantitative information of substances in living organisms
|Jun 7, 2005
|Dec 7, 2006
|Chemlmage Corporation
|Non-invasive biochemical analysis
|Nov 3, 2005
|Dec 7, 2006
|Chemimage Corporation
|Invasive chemometry
|Jul 24, 2006
|Mar 1, 2007
|Kate Bechtel
|Intrinsic Raman spectroscopy
|Apr 27, 2006
|Mar 15, 2007
|Martin Hunter
|Raman spectroscopy for non-invasive glucose measurements
|Mar 1, 2007
|Jun 28, 2007
|Vahram Mouradian
|Methods and devices for non-invasively measuring quantitative information of substances in living organisms
|May 9, 2007
|Nov 15, 2007
|Kiani Massi E
|Systems and methods for calibrating minimally invasive and non-invasive physiological sensor devices
|Feb 11, 2008
|Sep 18, 2008
|Chemimage Corporation
|Invasive chemometry
|Oct 3, 2008
|Apr 23, 2009
|Zhi Xu
|Optical device components
|Oct 22, 2008
|May 7, 2009
|Zhi Xu
|Optical device components
|Mar 20, 2009
|Oct 1, 2009
|The Curators Of The University Of Missouri
|Method and System for Non-Invasive Blood Glucose Detection Utilizing Spectral Data of One or More Components Other Than Glucose
|Apr 17, 2009
|Nov 26, 2009
|The Curators Of The University Of Missouri
|Method and System for Non-Invasive Optical Blood Glucose Detection Utilizing Spectral Data Analysis
|Mar 23, 2010
|Oct 7, 2010
|The Curators Of The University Of Missouri
|Optical spectroscopy device for non-invasive blood glucose detection and associated method of use
|Oct 23, 2007
|Dec 2, 2010
|Cybiocare, Inc.
|Non-invasive pressured probing device
|Mar 9, 2005
|Sep 29, 2010
|Method and device for microcalorimetrically measuring a tissue local metabolism speed, intracellular tissue water content, blood biochemical component concentration and a cardio-vascular system tensio
|Mar 10, 2006
|Oct 5, 2016
|DexCom, Inc.
|Methods for processing analyte sensor data for sensor calibration
|Oct 23, 2007
|Nov 13, 2008
|Cybiocare Inc.
|Non-invasive pressured probing device
|Jul 1, 2010
|Apr 21, 2011
|Freelance Corporation
|Devices, methods, and kits for determining analyte concentrations
|U.S. Classification
|600/316, 600/322, 600/365
|International Classification
|Cooperative Classification
|European Classification
|Jan 31, 2001
Owner name: MEDOPTIX, INC., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BERMAN, HERBERT L.;ROE, JEFFREY N.;BLAIR, ROBERT N.;REEL/FRAME:011491/0110
Effective date: 20010110
|Jun 10, 2003
|Certificate of correction
|Sep 27, 2005
Owner name: VIVOMEDICAL, INC., CALIFORNIA
Free format text: CHANGE OF NAME;ASSIGNOR:MEDOPTIX, INC.;REEL/FRAME:016844/0143
Effective date: 20050804
Owner name: VIVOMEDICAL, INC.,CALIFORNIA
Free format text: CHANGE OF NAME;ASSIGNOR:MEDOPTIX, INC.;REEL/FRAME:016844/0143
Effective date: 20050804
|Sep 6, 2006
|Maintenance fee reminder mailed
|Feb 18, 2007
|Lapse for failure to pay maintenance fees
|Apr 17, 2007
|Expired due to failure to pay maintenance fee
Effective date: 20070218


text:
Contact Info / Websites
- Skype
- EarthAndI53
Entry #29
You guys, I've been considering posting some covers to my website, YouTube, etc. But as the subject of the post would suggest, I'm just not sure. Two years back, I never would've considered it. I was awful. But since then, I've taken chorus, and my teacher has helped SO much. Recently, I've gotten quite a few compliments, from those who have heard my solo voice. But, the reason I'm concerned is my friend Felisha has a beautiful voice and has put a few songs on YouTube, but got attacked for no apparent reason. Normally, if someone says something to my face about my singing, I can handle it. But the internet is relentless. I'll think about it, and if I do decide to post something, I'll pick a song that I know I can do. :3
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subset: commoncrawl


text:
Many Nations Still Face Economic Despair
August 7, 2003
For many countries, the 1990s were years of despair, the recently released Human Development Report 2003 of the United Nations Development Program concludes.
The latest report emphasizes goals established by the United Nations in its Millennium Declaration of 2000, which ideally are to be met by 2015. They include halving poverty and hunger rates and reducing child mortality by two-thirds.
So how has the world done since 1990?
- Fifty-four countries are poorer, as measured by per capita Gross Domestic Product (GDP).
- Sub-Saharan Africa is worst off, with per-capita GDP falling in 20 nations.
- It fell in 17 nations in Eastern Europe, six in Latin America, and six in East Asia and the Pacific.
- The rate of hunger has increased in 21 nations.
- The proportion of children who die under the age of 5 has risen in 14 nations.
Still, some countries, even poor ones, have done well by many measures. China and India stand out, of course. Ghana reduced its hunger rates greatly in the 1990s, and conditions in Vietnam improved significantly.
And some take solace in the fact that only 23 percent of the global population lives on less than $1 a day, compared with 30 percent in 1990. But most of this improvement has to do with the stunning economic progress in China. In absolute numbers, more people are now extremely poor than in 1990 if China is excluded.
The bottom line is that at this rate, some crucial goals set for 2015 will not be met by many regions for several decades, and in some cases not until the next century.
Source: Jeff Madrick, "Grim Facts on Global Poverty," New York Times, August 7, 2003.
Browse more articles on International Issues


text:
Millennials Fail To Keep Up With Mom And Dad
13.01.17 16:42
WASHINGTON (dpa-AFX) - Millennials are earning 20 percent less than their parents did and have accumulated only half the assets than their baby boomer parents, new research showed.
According to an analysis of Federal Reserve data by the advocacy group Young Invincibles, baby boomers were much more financially secure than millennials when they were the same age.
For their research, the analysts compared people in the age group of 25 to 34 years in 2013, the most recent year available, to the same age group in 1989 after adjusting for inflation.
"The American Dream promises that the next generation will fare better than the previous one. However, young Americans today may be on track for lower lifetime earnings than their parents," according to the report.
The analysis showed that boomers earned higher incomes, amassed greater assets, were more likely to own homes, and had greater net wealth when they were young adults than today's young people.
Millennials in 2013 had a median household income of $40,581, down 20 percent compared to young adults in 1989. The decline in income is despite millennials being better educated.
In fact, today's young adults with debt and a degree earn roughly the same amount as that earned by workers with no degree in 1989. However, the report noted that a college degree - with or without debt - is still worth it.
In addition, fewer millennials have a lower rate of home ownership than boomers. Only 43 percent of millennials owned a home in 2013, compared to 46 percent in 1989. However, the rate of home-ownership for college-educated young adults has increased.
As young adults, baby boomers owned twice the amount of assets as young adults in 2013. Also, the net wealth, or net worth of millennials was $10,900, 56 percent lower than it was for boomers.
The research also found that white millennials still earn significantly more than their blacks and Latino peers.
Copyright RTT News/dpa-AFX


text:
0292 192 1829
Slater and Gordon Lawyers are one of the largest Personal Injury Law Firms in the UK. Our Solicitors deal with every type of personal injury claim from car accidents to Asbestos compensation claims. Read more.
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Slater and Gordon Lawyers is home to the largest group of family Lawyers in the country with offices across England & Wales. Contact us to give advice on your issue along with information on flexible pricing and fixed fee services. Read more.
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Claire is an employment law solicitor at Slater and Gordon Lawyers in Cardiff with experience in advising clients on a wide range of issues, including settlement agreements, negotiated exits, redundancy, unfair dismissal, disability discrimination, equal pay and contractual issues.
She has particular experience acting for clients with mental health conditions who are pursuing disability discrimination claims and has successfully resolved cases including failure to make reasonable adjustments for her clients.
As well as acting for individuals, Claire has dealt with a significant number of collective claims for employees, including settling multi-million pound equal pay claims and running blacklisting cases in the High Court. She has advised on the employment law issues arising out of large closures of mines in South Wales and has directed employees on the redundancy process, apprenticeship contracts and duty consultation.
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Slater and Gordon (UK) LLP is authorised & regulated by the Financial Conduct Authority (FCA) for insurance mediation activity.


text:
* Promo codes do not apply to this product, due to the brand's request.
Thierry W Despont is an architect, designer, and artist. Following his exhibition at the Marlborough gallery in Chelsea, New York, this book explores the unique worlds he assembles from found objects. Despont is ranked as one of the top residential designers of North America and Europe and has worked on many high-profile projects, including the Statue of Liberty, the Frick family mansion, and the Jean Paul Getty Museum.
By Thierry W Despont
13.0 x 16.5 in - 32 x 42 cm
120 Pages | 100 Images- Hardcover | Printed on art quality cotton
AHAlife is committed to help you live a conscious and inspired life.
Many of the items you discover here are exclusive to AHAlife, which is what makes our community of designers and artisans so special.
If you find one of our products anywhere else for less than it's being sold on our site, we will match it. No questions asked.
Our dedicated Concierge Team is here to help. Reach out any time at:


text:
The Greatest Speech Ever Made
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text: If you are sideloading applications, here's something you should know. There's a Linux distribution called Alpine Linux that uses the same extension for packages as Android, .apk. DO NOT install Alpine Linux packages on Android. They will not work. Alpine Linux packages are compiled for your PC, NOT your phone.


text:
Vintage DOLLHOUSE Miniature Maple Wood Sideboard BUFFET
Sold for:
Start Free Trial
or Sign In to see what it's worth.
- Sold Date:
- Source: eBay
Sideboard Buffet Table
Maple Wood
This is a Wood Buffet with actual pullout drawers Measures: 6" x 3" x 1.5" Brass Drawer Pulls show some oxidation Previously Owned Check my other items for other Dollhouse Furniture and Accessories 100% Money Back Guarantee if you are not happy with your purchase. If item received does not meet your expectations just contact us for return instructions Check out my other items ! Customer Service is Our #1 Priority! Please Be assured that we will provide 5 Star Service on All Levels. Payment Instructions: We accept PayPal as our preferred payment method. Please pay within 5 days of purchase. If there is a problem please contact us for arrangements. Be sure to add me to your favorites list ! We Combine Shipping! After your purchases just contact us for a reduced shipping rate based on the combined weight of your items. We pride ourselves on our shipping. We will ship your purchase either same or next business day after cleared payment is received. We keep our costs to you down to a minimum based on Shipping Services Actual Rates and a small handling fee to cover our shipping expenses. Sign up for my email newsletters ... read more


text:
Bryan & Ridge, a Chiswick based firm of Chartered Accountants and Tax Advisors, has merged with PK Group, the London based firm of accountants and financial advisors, extending the range of services and offering exciting new opportunities for the merged business. The partners expect the arrangement to benefit all parties.
PK Group welcome the Bryan & Ridge team of chartered accountants and chartered tax advisors to the PK team.
Patrick Kennedy, CEO of PK Group commented on the agreement: 'Bryan & Ridge are well known in Chiswick and West London for the exceptional level of service they give to their clients. Bryan & Ridge and PK Group share common values and we are very excited to be working alongside the Bryan & Ridge team, building on the strong reputations of both firms.'


text:
X-Men vs Mad Men Don Draper in "Draper's Days of Future Past." To save the world Professor X, Mystique, Magneto, & Wolverine travel back in time to prevent the worst kind of destruction, self-destruction. They must stop Don Draper from completely imploding, and taking down all of humanity with him. In the second parody installment from Quizno's Toasty.TV, Don Draper takes on the X-Men for a battle like no other.
Mad X-Men: Don Draper's Future Past Parody
Like our Fortress of Solitude Facebook page and Follow us on our @Fortressofs Twitter account.


text: + "The open-faced sandwiches who take risks & live big & smile with all of their teeth. These are the people I want to be around. This is the honest way I want to live." #yesplease #timehop #habitatforhumanity Jade Bryce, June 17, 2015, SOCIAL, habitatforhumanity, timehop, yesplease, 1 0 Be the first to like this! Read more


text:
This article has Open Peer Review reports available.
Prevalence of coronary artery disease risk factors in Iran: a population based survey
- ZN Hatmi1Email author,
- S Tahvildari2,
- A Gafarzadeh Motlag3 and
- A Sabouri Kashani4
© Hatmi et al; licensee BioMed Central Ltd. 2007
Received: 27 December 2006
Accepted: 30 October 2007
Published: 30 October 2007
Open Peer Review reports
Pre-publication versions of this article and author comments to reviewers are available by contacting firstname.lastname@example.com.
|Original Submission
|27 Dec 2006
|Original manuscript
|27 Jun 2007
|Reviewer Report - Johannes van Rooyen
|Resubmission - Version 2
|Manuscript version 2
|Resubmission - Version 3
|Manuscript version 3
|21 Aug 2007
|Reviewer Report - Johannes van Rooyen
|3 Oct 2007
|Author responded
|Author comments - zinat hatmi
|Resubmission - Version 4
|3 Oct 2007
|Manuscript version 4
|30 Oct 2007
|Editorially accepted
|30 Oct 2007
|Article published
How does Open Peer Review work?
Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting firstname.lastname@example.com. All previous versions of the manuscript and all author responses to the reviewers are also available.
You can find further information about the peer review system here.


text:
Valencia youngster Fran Villalba has rejected interest from Manchester United to sign a new four-year contract at the Mestalla.
The 18-year-old, who was handed his senior debut at Valencia last season by former Red Devils defender Gary Neville, was a target for Man United, according to the teenager's agent Vicente Flores.
It had been thought that the English giants would attempt to entice the midfielder with an offer in January, but the young Spaniard has decided to pen a new contract with Los Che.
"Very satisfied to have renewed for four years with the club of my life," Villalba wrote on Twitter. "I will keep working to play my part for this great club."
Muy contento por renovar 4 años más con el equipo de mi vida.— Fran Villalba (@franvillalba10) October 18, 2016
Toca trabajar para aportar mi granito de arena a este gran club.#AMUNT #VCF pic.twitter.com/0zBz4iswDI
Villalba has made four first-team appearances for Valencia, but has yet to represent the Spanish giants this season.


text:
Social Media sites such as Pinterest give us a glimpse into how the modern Bride wants to look on her wedding day. One trend we're seeing over and over is how Brides are incorporating a splash of color into their wedding attire. From colored shoes to hot pink petticoats, Brides these days are stepping away from all white.
We went to Donna Holland, owner of Party Dress Express, New England's #1 Retailer for Proms, Weddings and Special Occasions, to find out why this trend is so popular and what are the different ways Brides can bring color to their big day.
Something Blue: "We're obviously always seen the color blue used in a Bride's wedding attire as her "something blue." When I first started out, the use was subtle, perhaps a Bride was carrying a small blue handkerchief or she had a small blue ribbon pinned under her hem. But soon, we saw Brides be bolder. They wanted their something blue to be their dyed shoes or a statement necklace."
But how did we then get to hot pinks, crisp oranges and pops of purple accenting a Bride's wedding gown? Holland explains, "It's really about a Bride's desire to be unique and show off her personality."
How To Play With Color on Your Big Day
The biggest decision a Bride-To-Be will make after saying, "Yes, I will marry you!" is choosing her gown. But Holland told us, "That's where the fun begins! That's when you can start incorporating color with your wedding dress through accessories and more. We find most Brides like to either use colors from their wedding palette or a color in that family. But we've also seen, say, a Groom veto pink for the wedding and the Bride be able to express her love of that color with a gorgeous statement necklace.
Feeling like you might want to infuse color in your big day but not sure how to start? Holland gives us six great ways to play up color!
Poses & Photos We Love:
Adding Color to your Wedding Wardrobe
Find more inspiration on how to incorporate color into your wedding day with the above 6 ideas.
Groom's Fashions:
Suits & Tuxedos: 5 Trends
Beyond the Boutonniere
Grooming Tips
Groom's Accessories
Find more groom articles >
Misc Articles:
Bridesmaids' Dress Trends
Bridal Purses
Rehearsal Dinner Dress
Wedding Bands
Find more misc articles >


text:
No 4 - SAINSBURY'S: 12 for £5.99 (50p per cracker): Appearance
(judged by Peter Kimpton). The words 'season's greetings' written on a
purple or gold background. "Fairly average. Metallic looking. Just about
gets away with it." Rating: 6/10
Bang for your buck: 81.1 decibels. Rating: 9/10
The best Christmas crackers of 2011, part 1
50p Christmas cracker triumphs
Christmas decorations and snowball fights banned under health and safety
Field hospital set up for Cardiff's 'black Friday' revellers
No place for the mean of spirit this Christmas
Stylish headphone sets for Christmas
Harry Hill's top alternative Christmas albums
The true spirit of Christmas: the best 10 ales for the festive season
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text:
Games johnnytwoshoes the great sperm race
Johnny Two Shoes is an indie game development studio based in London, UK. Johnny Two The Great Sperm Race was released in March as a commission for Channel 4, funded by the Wellcome Trust. The game was built as a. The Great Sperm Race is a Casual game on the Johnny Two Shoes site. It is the first game created. This is the journey of a sperm to the egg, race to the end and learn about how it all works. JohnnyTwoShoes developed this game for Channel4 in conjunction. Mission of The Great Sperm Race is to be the first on the egg! Race against other sperm and fertilize the egg. Control the single sperm with the. Kongregate free online game The Great Sperm Race - Millions die and only This is the journey of a sperm to the egg,. johnnytwoshoes. You control a sperm and your goal is to make it to the egg in the shortest possible time. YOUR BEST TIME. A. GAME. Open to the outside world as the birth. canal, the vagina . SandStorm Racing by johnnytwoshoes. Game.


text: Eskimeaux just dropped a new track "I Admit I'm Scared" off her upcoming album O.K. which will be released on her bandcamp and Double Double Whammy Records on May 12. Eskimeaux is Gabrielle Smith, who has been making music under the moniker for many years now and also plays in Frankie Cosmos, as well as other bands in the art collective The Epoch. "I Admit I'm Scared" might be familiar to her fans, but its been reworked here for release on the album. As Smith's voice delicately trembles over her guitar, you can't help but feel her trepidation. Smith reaches deep down for this one, making it a touching and personal listening experience about the pains and potential rewards of confronting someone. For fans of Mitski, Girlpool and Bellows, the new one from Eskimeaux is not one to snooze on!


text:
BRUSSELS, May 10 (Reuters) - Retail group Ahold Delhaize reported on Wednesday a higher-than-expected operating profit in the first quarter, aided by cost savings that offset weaker sales in the United States.
The company, which was formed after Dutch Ahold merged with Belgium's Delhaize last July, reported a first-quarter operating profit, adjusted for one-off items, of 604 million euros ($657.76 million), above the average forecast of 589 million euros in a Reuters poll.
Ahold Delhaize, which operates supermarket chains such as Food Lion and Stop&Shop in the United States, said it also expected profit margins for 2017 as a whole to be above those of last year, repeating that it was still aiming for 220 million euros of savings coming from the merger this year. ($1 = 0.9183 euros) (Reporting by Robert-Jan Bartunek; editing by Philip Blenkinsop)


text:
Whale-watching and Herring Fishing: Joint or Independent Production?
The effects of "localized depletion" of a pelagic fishery (herring) on a non-extractive marine activity (tourism) are investigated. Proponents of the localized depletion theory claim that intense fishing effort can lead to areas that are unsuitable for predators like tuna, groundfish, and whales. This leads to poor outcomes for the fishing and whale-watching industries. However, there has been no consensus in the scientific community about the existence of this phenomenon. Localized depletion would be consistent with an economic theory of joint production, in which nearshore herring stocks are an input in production of both herring and whale-watching trips. A unique dataset of daily whale-watching outcomes is combined with fishing effort and oceanographic data. This dataset is used to test the hypothesis that intensive fishing effort increases the search time of whale-watching companies. Our results suggest that while fishing has a statistically significant impact on sightings, this magnitude of this effect is fairly small. Sightings seem to be determined mostly by large scale oceanographic processes. These results should be of interest to policymakers in determining future fishing regulations.
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Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Kathryn D. Bisack & Jon G. Sutinen, 2006. "Harbor Porpoise Bycatch: ITQs or Time/Area Closures in the New England Gillnet Fishery," Land Economics, University of Wisconsin Press, vol. 82(1), pages 85-102.
- Ragozin, David L. & Brown, Gardner Jr., 1985. "Harvest policies and nonmarket valuation in a predator -- prey system," Journal of Environmental Economics and Management, Elsevier, vol. 12(2), pages 155-168, June.
- Hoekstra, Jeljer & van den Bergh, Jeroen C.J.M., 2005.
"Harvesting and conservation in a predator-prey system,"
Journal of Economic Dynamics and Control,
Elsevier, vol. 29(6), pages 1097-1120, June.
- Jeljer Hoekstra & Jeroen C.J.M. van den Bergh, 2001. "Harvesting and Conversation in a Predator-Prey System," Tinbergen Institute Discussion Papers 01-024/3, Tinbergen Institute.
- Squires, Dale & Kirkley, James, 1991. "Production quota in multiproduct pacific fisheries," Journal of Environmental Economics and Management, Elsevier, vol. 21(2), pages 109-126, September.
- Hannesson, Rognvaldur, 1983. "Optimal harvesting of ecologically interdependent fish species," Journal of Environmental Economics and Management, Elsevier, vol. 10(4), pages 329-345, December.
- J.J. Agar & J.G. Sutinen, 2004. "Rebuilding Strategies for Multispecies Fisheries: A Stylized Bioeconomic Model," Environmental & Resource Economics, Springer;European Association of Environmental and Resource Economists, vol. 28(1), pages 1-29, May. Full references (including those not matched with items on IDEAS)
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text:
You Here : Home > Windows
IP Camera Viewer 1.16
OS Support:
Win2000, Win7 x32, Win7 x64, WinOther, WinServer, WinVista, WinVista x64, WinXP, Other
Old version
December 31 2011
IP Camera Viewer 1.16
Set up a FREE IP camera monitoring system within minutes! IP Camera Viewer is an alternative to the flimsy software that is shipped with most network IP cameras. Keep an eye on your home, office, parking area or anywhere you have a IP camera.
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Anne Thompson @ Variety posted this great piece about some of the exciting visual moments that are on display during SHINE A LIGHT. The film is released April 4, and will be also shown on IMAX screens. Here's the link to Thompson's article:
Friday, March 21, 2008
Martin Scorsese's upcoming feature doc on the Rolling Stones, SHINE A LIGHT, will be featuring camerawork from some of the world's best cinematographers. The line-up includes: Robert Richardson (JFK, NATURAL BORN KILLERS, CASINO), Emmanuel Lubezeki (CHILDREN OF MEN, THE NEW WORLD), Robert Elswit (THERE WILL BE BLOOD), John Toll (THE THIN RED LINE, BRAVEHEART), Mitchell Amundsen (TRANSFORMERS), Declan Quinn (IN AMERICA), Stuart Dryburgh (THE PIANO), Ellen Kuras (SUMMER OF SAM), Albert Maysles (GIMMIE SHELTER), Anastas Michos (MAN ON THE MOON), and Tony Janelli (LAW & ORDER).
2 comments:
- Wayne said...
WOW. I had no idea so many great DPs were a part of this!
- March 21, 2008 at 10:52 AM
- Seth said...
Here's my email address:
- March 24, 2008 at 6:44 AM
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text: I want to share my experiance of doing 3M wax coating for my linea. The story starts like this. In my linea in the driver side two doors back and front there was a big scratch starting from back door to my front door. I planned of painting my door. I went to Tafe reach chennai and enquired about the rate .They told that three panal has to be painted and will cost around 10000 rs. I was not ready to spend so much money for that. THen i heard from my friend that if we do was coating we can remove some minor scratches. I searched in internet and got the details of the new 3M showroom in nungambakkam. I called to the number available in the net .A person named Dushy attended my call and asked me to come for a demo. Next day i reached the showroom at 5.30 pm .They had showed a demo in the scratched door and they told that deep scratches are very difficult to remove. Once the demo is over the scratches became dull but not completely gone.He told me that once we do the whole polising it will be even more dull. I booked an appointment on 23-08-2012 . On the same day morning i went to the showroom at around 10.30 am and gave my vehicle .He told that he will inform me once the work is over .by 3.00pm on the same day i got a call telling that the work is over.When i reached the showroom i was surprised to see my car. It looked as a brand new car in showroom condition.I am attached the photos before and after the service. The 3M showroom guys are very good in the service. After finishing the work i pointed out some area where the was is not done properly. They were ready to clear that area without any hesitation.After the work is over they had given some tips to maintain the car like this for ever.Totally i am very much happy with the work.


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Lovely Piece of Vintage Metallic Trim 54 Inches
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- Sold Date:
- Source: eBay
Lovely Piece of Vintage Metallic Trim 54 Inches This auction is offering a wonderful piece of vintage French gold metallic trim with and Art Deco Look in the design. This piece measures 1" wide and 54" long. It is in good condition. Shipping will be $1.50. Thank you. NO RESERVE . payment must be received within 10 days of auction closing. Buyer to pay shipping/handling and insurance.I will combine multiple auctions for shipping. Please allow time for Personal check to clear or send m.o. for quick shipping. All shipping quotes are for the USA. Please inquire for international shipping quotes. Insurance will be offered on all items over $25.00. I do pack each piece as if Armegdon was upon us but sometimes the post office is oblivious of careful package handling. I cannot refund for damage done in shipping if no insurance was purchased.I would suggest that you protect your purchase with insurance. If a refund is necessary, I cannot include refund for postage. Everything I sell is either antique, vintage or collectible. I describe the merchandise to the best of my knowledge and try to take good photos of the pieces. If you have any doubts as to quality or condition, please ask questions. I always try to sell my items in the best condition possible for their age. I do list any major flaws. I am sorry but ... read more


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Where can I get a voter registration card in San Francisco?
After processing your registration form, the Department of Elections will mail a Voter Notification Card within three to four weeks. If you have NOT received a Voter Notification Card or wish to check your voting status, you may use the voter registration look-up tool.
You can also get a voter registration card in San Francisco at the San Francisco Department of Elections, local public library branches, the Department of Motor Vehicles (DMV) and U.S. Postal Service stations. If you need assistance completing the voter registration card, call the Department of Elections at (415) 554-4375.


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|Winter Squash
Mom's Winter Squash
Wash the squash and cut into halves or quarters. Remove the seeds. Place the pieces in a Pyrex flesh down. Add a 1/4 to 1/2 inch of water to the bottom of the Pyrex dish. Cover with foil. Bake at 350 for 45 minutes to 1 hour or until tender. Drain the water off and turn the squash flesh side up. Season with salt, pepper, and butter. Serve warm.
Source: Robyn Sorenson


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We were waiting for the Hyve device from the news regarding the next big cooperation of the company with the MediaTek. And finally, the wait is over with a Deca-Core processor powered smartphone that they called Pryme. It is the first MeidaTek Deca-Core processor ever produced for a smartphone. So that, it stands out of the crowd as they announced recently. The device is also powered by 4GB RAM and with a 3500mAh average battery. Sweetening the features, there is a 2-year warranty on the smartphone where they hit the right spot.
It is very rare to see a smartphone that breaks the 1-year warranty line, and the Hyve Pryme is such a nice device with some extended warranty. So, the users can breath effortlessly with the device for an extra year without worrying about any damages. In addition, the company announced that the device will support 4K video recording. The nicely placed camera on the backside will be able to capture the life's most beautiful moments using one of the world's most advanced smartphone video capturing technologies.
Looking at the design gives a good impression of the device which is similar to some Gionee smartphones. But yes, it feels good in hands and has no slippery parts all around. On the top and bottom of the back cover, there is a color change that gives a nice look. Under the camera, the fingerprint sensor is placed nicely with a good reach of the fingers. The pricing details are not yet out and expecting to be reached ears soon. Once we get more details regarding the device, we will update the post or add new.
We just got a spec sheet of the device. Have a look.


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A trip to London usually includes a few essential missions, check out Stolen Space and everything else on the ever changing walls up Brick Lane, fire into Tate Modern and have a walk along the river and hopefuly catch any other decent art shows that happen to be on. However with only a day to really get out and explore London's cultural offerings I found myself running about like a mad thing taking in 6 different shows and one of them happened to be the 'Ritual Spirits' exhibition by 3D aka Robert Del Naja of Massive Attack fame.
If your a Massive Attack fan then you've already been exposed to 3Ds distinctive artwork. Creating his own motifs and using strong symbolism such as the flame logo on Blue Lines or the dark brooding stag beetle on Mezzanine, 3D has established a style and aesthetic which is uniquely his own, but its something he's been working on for decades, pre Massive Attack as part of Britsol's soundsystem / graffiti collective the Wild Bunch. There's a great looking tome of a book, 3D and the Art of Massive Attack which will be the next addition to my expanding art library and looks packed with career spanning photos and art work.
This latest batch of work draws on 3D's massive archive of work and saw him create a series of limited edition prints with Lazarides Editions, an offshoot of Lazarides Gallery with each print being hand finished and embellished by 3D. The show coincided with the release of new music from Massive Attack in the form of the 'Ritual Spirit' ep which was released on a limited edition vinyl, each one with a hand printed cover by 3D. Gold dust you say. 3Ds work is pretty iconic and seeing it in real life was pretty cool, the holes where he'd used a blow torch to burn through the prints and just seeing images you've seen at CD size in all their full size glory. It looks like 3D is quite full on when making work and there's a real physichality to his process and methods which comes across in the work. You can check out a great interview with him in VNA Magazine # 26.
Its the first time I've been to a Lazarides show and I have to say the staff were really cool and gave me a good introduction to the work and the show, something you don't always get. I was bit gutted I didn't make it to their A Decade of Lazarides show at the main gallery as it contains work by some of my favourite artists but seeing 3D's show made up for it.
Ritual Spirit runs until the 5th March with all work for sale and if you're a big fan you can order a Massive Attack Logo print portfolio online here. What I'd give for one of those orange Heligoland prints!


text: Selling in over 200 territories worldwide, with 25 licenses in place and a new show commissioned for tx 2016 Mister Maker is an established hit. Zodiak commissioned Skew to rebrand the show, create a fresh look for packaging and supporting iconography. The design team got hands on and made layered individually crafted card models that we then polished into the final identity.


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Shanghai, Nov 14 (UNI) Veteran tennis ace Leander Paes' desire to win a third Masters Cup doubles title remained on course as he and his Czech partner Martin Damm stormed into the semi-finals of the Tennis Masters Cup here.
The fourth seeded Indo-Czech pair prevailed over the Israeli duo of Jonathan Elrich and Andy Ram 6-4, 7-5 in a round-robin game yesterday and became the first pair to book a last four berth in the doubles competition.
It was the 2006 US Open doubles champions third win in four outings over their Israeli counterpart, who came into the tournament as a late replacement for World number one combo of Bob and Mike Bryan of United States.
Earlier, Paes-Damm pair, who came into the tournament after first round exits in the ATP Masters Series events in Paris and Madrid, defeated defending champions Jonas Bjorkman and Max Mirnyi 6-4, 6-1 in their opening doubles match of the season-ending tournament.
The Indian Davis Cupper had earlier won the title twice -- first in 2000 with his estranged partner Mahesh Bhupathi and then in 2005 with Serbian Nenad Zimonjic.


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Mets' Injury Report Doesn't Look Like It's Easing
Several injured Mets aren't close to returning from injury.
Several injured Mets aren't close to returning from injury, and the news is especially bad for pitcher Jeremy Hefner. Collins said that "Tommy John surgery has been recommended" for the 27-year-old right-handed starter, though the manager said Hefner may seek a second opinion.
Collins also said that 23-year-old right-handed starter Jenrry Mejia will have surgery within 10 days to remove bone spurs from his pitching elbow....


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Krosis (Revision 4326)
Krosis gives +20% to Lockpicking, Archery, and Alchemy. It has an armor rating of 46, weight of 5 and value of 1615 (with level 27 speech). It is light armor.
It can be found at Shearpoint which is between Saarthal and Fellglow keep (closer to fellglow keep on top of the nearby mountain).
The easiest way to fight Krosis is right before he arises get the 3 shouts behind him. By the time you do this he'll be attacking you so it's a good idea to have a potion of resist magic used. Fight him and stagger him or wait untill he floats out of veiw, then use the whirlwind shout and sprint untill he doesn't attack you, you may need to use an invisible potion to do this. At this point he may
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Dragon Priest Masks | Shearpoint | Dragon Priests Locations | Armor Item Codes


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In the Purdy case [2009] UKHL 45, the House of Lords required the Director of Public Prosecutions to issue an offence-specific Policy setting out the facts and circumstances which would be considered in making a decision whether to prosecute a person for encouraging or assisting suicide (or attempted suicide) under section 2 of the Suicide Act 1961. The Policy has now been issued - see Crown Prosecution Service.
Section 2 of the 1961 Act was recently amended by the Coroners and Justice Act 2009 s.59. The essence of the offence is doing an act which is capable of encouraging or assisting another to commit suicide (or attempt suicide) with INTENT that the other is encouraged or assisted. The maximum sentence of 14 years imprisonment was retained.
The Policy document does not contain an exhaustive list of factors but 16 factors are set out which would tend toward a prosecution and 6 factors which would point against. The CPS emphasize that a "tick box" approach will not necessarily make the decision.
Looking at the Policy, it continues to be somewhat unclear whether a loving husband who purchases travel tickets for his wife, for whom life has become unbearable as a result of progessive disease such as Multiple Sclerosis, to travel to a certain clinic in Switzerland might be liable to prosecution. The Policy, whilst not changing the law, might make matters somewhat clearer in some cases but there would still be an investigation with no advance certainty as to the possible outcome. A prosecution might still follow. Only time and a tragic case will inform us further.
The blog of ObiterJ - responsible and sometimes critical comment on legal matters of general interest. This blog does not offer legal advice and should not be used as a substitute for professional legal advice. 'The life of the law has not been logic; it has been experience. The law embodies the story of a nation's development...it cannot be dealt with as if it contained the axioms and corollaries of a book of mathematics' - (Oliver Wendell Holmes - 1841 to 1935). Pro Aequitate Dicere
Thursday, 25 February 2010
Complicity in Suicide - New Guidelines but ....?
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Last spring, I bought the "Lil Twister" at a quilt show. I'm always a sucker for new notions, and this one looked like fun.
Around the same time, I won a charm square pack from AJ at I Knit n Quilt 2. It was Martinique, by 3 Sisters. Beautiful, soft browns, greens and pinks.
I finally tried out the Twister on these charm square fabrics.
First, I sewed all the charms together
Next, I had to pick a border fabric. For some reason, I have lots in my stash to choose from!
Here is the Twister template. It has lines on it, set on the diagonal. You place these lines on the seam lines of your patches, and cut around the template.
Then, you lay out the newly cut pieces in exactly the same order that they were in as you cut them out. Voila – twisted blocks!
As your border has become part of the twisted blocks, you need to add on another border. Here it is unquilted
I decided to quilt it in diagonal, parallel lines. The lines are about an inch apart.
You can't see the binding very well, but I found a soft green stripe in my stash that worked well.
It finished up at about 30 x 33 inches. Just a nice size for a table topper.
The Twister does leave a lot of fabric behind. Being the thrifty person that I am, noticed that the pieces left included 42 squares about 2 1/2 inches in size. I cut them down to 2 inch and added them to my leaders and enders. Yes, they are cut on the bias, but I figure that they will end up sewn to lots of other pieces, so the bias won't have any harmful effect.
Saturday, December 29, 2012
Trying out the Twister
Labels: Table Runner, Twister
3 comments:
- Rosemary said...
I have had fun using the twister ruler. Your quilt came out so nice! I love the quilted lines. I also found use for my scraps. Like I need more fabric!!
- December 29, 2012 8:43 pm
- sew.darn.quilt said...
This is so pretty. I really like the fabrics you used :)
- December 29, 2012 8:55 pm
- Heather said...
I played with this last year and want to do more. might have to purchase the larger template as well.
- January 08, 2013 5:40 am
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text: If you want to attend the Del Close Marathon, you must either purchase a DCM Festival Pass or individual ticket(s) for premiums shows at FIT Haft Auditorium and SVA Theatre. Festival Passes grant access to all DCM theatres (space permitting) throughout the festival (Friday - Sunday), except to individual ticketed shows at SVA Theatre and FIT Auditorium and ASSSSCAT at UCBT Chelsea. Passes do allow you to to standby for these shows (see below).


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Strongsville, OH Painting Contractors
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Since 1990 we have provided superior performance of Commercial and Industrial Coatings to Buildings, Steel Structures and Equipment servicing Strongsville, Cleveland and Northern Ohio areas.
Alpha Painting can provide services such as sandblasting and coating, painting of industrial tanks and residential projects.
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Our company has built a reputation on quality work and honest service. We strive to exceed our client's expectations.
Contact Alpha Painting Inc. today at 440-846-0405 for all of your Strongsville, OH painting contractors needs.
Contact Information
Alpha Painting Inc.


text: Congressional leaders from both parties put on their happy faces after Tuesday's meeting at the White House, but nobody could point to any bipartisan progress made toward advancing Democrats' priority issues. Senate Majority Leader Harry Reid (D-Nev.) called the nearly two-hour meeting "productive." House Majority Leader Steny Hoyer (D-Md.) told reporters to expect President Barack Obama to issue an executive order "soon" to create a fiscal commission aimed at reining in spending. But GOP leaders exiting the meeting gave no sign that they are prepared to sign on to a bipartisan jobs bill, support Obama's call for a debt commission or help jump-start health care reform. Senate Minority Leader Mitch McConnell (R-Ky.) said lawmakers had "a good meeting" with Obama and pointed to potential areas of agreement with the administration: support for nuclear power, offshore drilling, clean coal technology and action on pending trade agreements. But McConnell noticeably avoided endorsing any of Obama's key initiatives. He said the Senate jobs package being crafted by Finance Committee members — which both chambers are looking to for movement on the issue — is "not ready yet," and most of his members have yet to see it. It is "hard to predict" where there is agreement in the jobs bill, McConnell said. "This is a package that is kind of a work in progress. We want to make sure it's not just another stimulus bill that will not create any jobs. So it's just too early to tell." Still, McConnell added: "There's a chance the Senate could get there with a small package." Neither McConnell nor House Minority Leader John Boehner (R-Ohio) committed to appointing any members to Obama's proposed debt commission. Instead, they said they want to see details of any such proposal first, according to a GOP source who was in the meeting. There were also warning signs that Democrats still aren't on the same page with each other on a jobs bill. Speaker Nancy Pelosi (D-Calif.) told the group that she has yet to talk to any small-business owners who would use the $5,000 jobs tax credit being pitched by Obama, said the GOP source. Hoyer later told reporters he saw potential agreement on the matter, however. In a press briefing after the meeting, Obama said that it may be more "realistic" for Congress to move quickly on a pared-down jobs bill. "It may be that the first package builds some trust and confidence that Democrats and Republicans on Capitol Hill can work together, and then we move on to the next aspect of the package and so forth. It may take a series of incremental steps," he said. Both McConnell and Boehner restated to reporters what has been their party's response to Democratic efforts to advance health care reform: start over. "It's going to be very difficult to have a bipartisan conversation with regard to a 2,700-page health care bill that the Democratic majority in the House and the Democratic majority in the Senate can't pass. So why are we going to talk about a bill they can't pass?" said Boehner. Obama later said that he isn't wed to any specific health care bills in the House or Senate. Instead, he said he is "open to any ideas" that promote the core goals of controlling costs, addressing insurance abuses and making insurance affordable. But he warned Republicans not to take his openness for granted. "What I won't do ... is another year of partisan wrangling around these issues; another six or eight months or nine months' worth of hearings in every single committee in the House and Senate where there's a lot of posturing," Obama said. The president also dismissed McConnell's examples of bipartisanship when the Minority Leader noted he and Obama both support offshore drilling and clean coal technology. "Well of course he likes that. That's part of the Republican agenda for energy," Obama said. "Bipartisanship can't be that I agree to all the things that they believe in or want, and that they agree to none of the things I believe in or want I'm willing to move off some of the preferences of my party in order to meet them halfway." Obama will meet with lawmakers from both parties again on Feb. 25, when he hosts a health care summit aimed at breaking the partisan logjam on health care reform. "My hope is that this doesn't end up being political theater ... I want a substantive discussion," said the president. "Let's establish some common facts. Let's establish what the issues are, what the problems are, and let's test out in front of the American people what ideas work and what ideas don't."


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PITCH #6: TALKS ON BASEBALL featuring Sid Seixeiro, Shi Davidi
Shi Davidi, Stacey May Fowles, Andrew Stoeten, Jeremy Taggart, Erin Valois
918 Bathurst: Culture, Arts, Media and Education Centre
918 Bathurst Street
Toronto, ON, M5R 3G5
Doors 6:30 PM / Show 7:00 PM (event ends at 11:00 PM)
Shi Davidi
Sportsnet Baseball Columnist
Stacey May Fowles
The Walrus, Deadspin, National Post
Andrew Stoeten
Baseball enthusiast, contributor to the National Post, blogger at http://andrewstoeten.com/.
Jeremy Taggart
Former drummer of Our Lady Peace, host of Taggart & Torrens podcast, regular contributor of Jay & Dan Podcast.
Erin Valois
Supervising editor @thescore. Formerly of @npsport. B.C. native. Into track, Olympics, college football, spinning, CMYK.
Upcoming Events
918 Bathurst: Culture, Arts, Media and Education Centre
- Sorry, there are currently no upcoming events.


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Bandana Snapback Cap by HEIST & CO.
Posted by Kevin, January 28th, 2014 06:01 am under Snapback, Street Wear
"The bandana pattern has been the outlaw symbol since the wild wild west and we are all about wild." HEIST & CO. takes the classic print and applies it to their Bandana snapback cap. The cap features an all-over Black/White print with an offsetting Red under-brim. The front panel has a subtle woven label in Black with White stitching. A simple but special aspect of the cap is the White top button, which contrasts the Black eye-lets. Purchase this cap at www.heistandco.com.