text:
Anne Vogt Jewelry
fine handcrafted sterling silver jewelry featuring
rare and unusual gemstones
About the Jewelry
Each piece of my jewelry is
individually constructed using a
fabrication process. That means no
mass production techniques
are used. Instead of creating molds
or assembly line production, I
build each piece from scratch.
The setting construction begins
with creating a thin strip (a
bezel) of silver made to fit each
The backing of the piece is cut out of sterling silver sheet.
Texturing is done with a rolling mill and textured paper
or fabric, or by hammering.
The bezel is soldered onto the base, and then any accessory pieces such as tubing, wire,
or accents are cut out and place on the base. Ear wires, pendant backs, or pin findings
are soldered last. There are 3 types of solder used on any one piece – all with different
flow – or melting – temperatures. This allows me to solder on the bezel, and then attach
other pieces later without the bezel falling off (the first solder used has the highest
temperature flow point).
Once the construction is complete, the stone is set.
Cleanup is a messy and slow process. This is where I first remove any excess solder,
clean up any file marks, or reach hard-to-get areas for pre-polishing.
The Flexible-shaft machine lets me clean, buff, and smooth out bezels.
Buffing and polishing – ugh! My least favorite part! A high speed motor with 2 wheels is
used with various compounds to remove fire scale (a shaded build-up that occurs during
soldering), eliminate scratches, and shine the surfaces. Very dirty work! Yes, I wear a
respirator, protective eye wear, and have a ventilation system.
Once it's polished to a bright shine, I use an ultrasonic machine to remove the messy compounds.
Sometimes I oxidize a
piece, and I bypass some
of the last of the buffing
process – I like that!! I
treat the finished piece to
create colorful patinas.
The process begins with the stones. My trademark is the
wide array of beautiful rare and unusual stones that I use. I
spend many hours selecting the highest quality, most unique
stones I can find. Many of them are from obscure single
deposits that are scarce or were completely mined out years
ago. Others are unique crystalline (drusy) stones found on
the inside of geodes. I also use rare fossils such as dinosaur
bone, fossilized coral, ammolite, and petrified palm wood. I
do include some more common stones such as onyx,
amethyst, malachite, and turquoise, so there is a more
affordable option.
Where do I get the stones, you ask? My main source has
been professional stone cutters who have approached me at
art fairs over the years. I have learned who carries the rare
drusy stones, who specializes in rare jasper & agates, and
who can find unusual material that I can't find anywhere
else. These cutters I have known for years and I trust them
to create unique shapes, clean edges, and a great polish. I try not to use many machine-
calibrated, mass produced stones. I also find stones at gem and mineral shows. That is a hit or
miss experience, where a lot of shopping is involved. It's a fun experience sorting through
dealers of rough rock, beads, fossil tables, carvings, and an occasional good quality stone-
cutter. So, it's all about the stones for me. I begin with the stones . . . These can be viewed with
descriptions on the
Hardness Scale
Caring for Stones
Birth Stones
E-Mail Me
Show Schedule & Awards
About The Jewelry
About The Artist
What's For Sale
Custom Orders


text:
If you've always wanted to have a medicine chest filled with hand-made, locally foraged remedies which you have a deep connection with this is the course for you - Christine, a student
Our senses were once an isntrument for discovery. A bitter taste would tell us of poison, a sweet one, a sign of nourishment. Through our senses we would instinctually know what to eat and what to use as medicine. We still have these senses and we can re-discover how to use them simply by taking the time to Listen.
Each month a mystery herb will be delivered to your door and you'll be guided through a mindfulness exercise with the tea. Only after you've had your experience will you find out what the herb is. By studying one herb each month you will become confident in using herbs effectively and safely without feeling overwhelmed. You will get a deep connection with each plant at a pace that suits you. Not to mention, the connection you'll establish with your body too.

subset: commoncrawl


text: Years ago Shlomo Adler heard the story of the miraculous rescue in Bolechow, Ukraine of the Jewish couple, Solomon and Malka Rainhartz, by a Ukranian girl. After the liberation, the Ukranian girl revealed her true identity as that of a Jewish girl born in the village of Synowodzko Nizne. The girl saved herself and the Jewish couple with courage, ingenuity and luck. "Jump my child. Maybe, thanks to you, there will remain a trace and memory of our family." These were the last words Donia heard from her father. She was 17 1/2 years old girl when she jumped into the unknown from the train that led her and her immediate family from Synowodzko Nizne, Ukraine to the extermination camp at Belzec. Shlomo Adler is a masterful storyteller who has taken it upon himself to reveal and memoralize the many stories of tradedy and also heroism of the Holocaust. The English lanuage version of his new book, Donia: Her bravery, Her Luck and Her Challenging Destiny is a must-read for those intersested in the Holocaust history, Jewish studies, human nature and psychology.


text:
Lancelot Du Lac won at Newmarket last time with Red Refraction behind and makes more appeal than other recent winners Bondesire and Right Touch as the latter pair step up in class. Secondo has claims back in this grade given he's still improving and is closely matched with Robot Boy on latest running. Hoofalong should also figure on his latest second over 5f at this track while Line Of Reason had CAN YOU CONGA back in seventh when winning at Pontefract in June. However, the latter has since improved and after landing a higher class sprint at Newmarket last time, Kevin Ryan's colt gets the vote to follow-up.
Lancelot Du Lac (ITY) 3-1 (9-4) Steadied in rear but in touch, headway halfway, soon chasing leaders, led over 1f out, stayed on well, won at Newmarket 6f 3yo hcp 0-90 (3) gs in Aug beating Kimberella (8-12) by 1/2l, 6 ran.
Secondo (FR) 7-1 (8-12) Raced centre, held up, merged with stand side group over 2f out, in rear, ridden 2f out, never a factor, 8th of 10, 8l behind Lucky Beggar (9-5) at Newmarket 6f 3yo hcp 0-105 (2) gf in Jul.
Robot Boy (IRE) 12-1 (8-10) In rear, never a factor, 7th of 10, 8l behind Lucky Beggar (9-5) at Newmarket 6f 3yo hcp 0-105 (2) gf in Jul.
Can You Conga 12-1 (7-11) Raced stand side tracked leaders, ridden to lead enterting final furlong, ran on, won at Newmarket 6f 3yo hcp 0-105 (2) gd in Aug beating Secretinthepark (8-8) by nk, 13 ran.
Dominate 14-1 (9-2) Always towards rear centre group, eased inside final furlong, 23rd of 24, 21l behind Seeking Magic (9-5) at Goodwood 6f hcp (2) gd in Aug.
Jadanna (IRE) 9-1 (9-5) Chased leaders, pushed along halfway, soon ridden, weakened over 1f out, 9th of 10, 12l behind Annunciation (9-13) at Ascot 6f 3yo hcp 0-100 (2) gd in Aug.
Hoofalong 5-1fav (8-7) Went badly right start and slowly into stride, soon tracked leaders, ridden to challenge over 1f out, edged left and led briefly inside final furlong, kept on, held towards finish, 2nd of 13, 1 1/4l behind Threes Grand (7-11) at York 5f Apprentice Handicap (0-100) (3yo) (2) sft in Aug.
Line Of Reason (IRE) 33-1 (8-7) Mid-division, headway to chase leaders halfway, weakened over 1f out, 15th of 20, 8l behind Tropics (9-10) at York 6f hcp 105 (2) gf in Jul.
Bondesire 3-1 (9-2) Led 1f, pressed leader, switched right over 1f out, ridden to challenge entering final furlong, led well inside final furlong, won at Ripon 5f 3yo hcp 0-85 (4) gs in Aug beating Jofranka (8-9) by 1/2l, 6 ran.
Shore Step (IRE) 5-1 (9-0) Led, ridden over 1f out, soon headed, no extra inside final furlong, 8th of 12, 6l behind Pal Of The Cat (8-2) at Goodwood 5f 3yo hcp 0-95 (3) gd in Aug.
Lastchancelucas 4-1 (9-2) Broke well, led 2f, chased leader, ridden 2f out, rallied inside final furlong, every chance towards finish, just held, 2nd of 7, hd behind Purcell (9-7) at Chester 6f 3yo hcp 0-90 (3) gs in Aug.
Red Refraction (IRE) 9-1 (9-2) Keen early, soon in touch, effort over 1f out, never able to challenge, 3rd of 6, 5l behind Lancelot Du Lac (9-4) at Newmarket 6f 3yo hcp 0-90 (3) gs in Aug.
Mary's Daughter 8-1 (8-5) Mid-division, ridden and headway 2f out, effort over 1f out, weakened inside final furlong, 11th of 13, 8l behind Threes Grand (7-11) at York 5f Apprentice Handicap (0-100) (3yo) (2) sft in Aug.
Right Touch 10-1 (9-3) Tracked leaders, driven to lead narrowly inside final 2f, soon ridden, held on under pressure final furlong, won at Newcastle 6f hcp 0-80 (4) gs in Aug beating Tajneed (8-8) by 1l, 14 ran.
Bachotheque (IRE) 20-1 (8-6) Always towards rear, 9th of 10, 8l behind Spinatrix (9-7) at Ripon 6f hcp 0-95 (3) gs in Aug.


text:
A&M Picks First Black Corps of Cadets Commander
Nearly half a century after African-Americans were admitted to predominantly white Texas A&M University, a black student has finally reached the pinnacle of one of its signature organizations.
Nearly half a century after African-Americans were admitted to predominantly white Texas A&M University, a black student has finally reached the pinnacle of one of its signature organizations.
In one of the most poignant ways of honoring a fallen comrade we've ever seen, former Navy SEAL Marcus Luttrell recently went to a Newtown, CT, pub and offered to pay the owner enough money to buy a random person a pint of Guinness every hour for the entire day.
Did you know that Texas allows military veterans to go to college tuition free? It's true. It's the law. So many people are taking advantage of this law to attend college that it's putting colleges and universities in a serious financial bind.
That's what we were told. The "official" story is that the founder and leader of Al Qaeda was given a burial at sea, only a few hours after commandos from the US Navy's SEAL Team 6 killed him in his home in Pakistan.
But there are now reports that it may not have happened that way. You be the judge.
Americans' fascination with the Navy SEALs translated to a big opening for 'Act of Valor,' which earned $24.7 million and first place at the box office this weekend.
The Michael E. DeBakey VA Medical Center in Houston has launched its own page on Facebook, in an effort to make it easy for veterans to have easy two-way communication with the VA and keep up with what's going on in the world of veterans' services.
The Pentagon is taking a significant step in the direction of allowing women to fight in combat. DOD officials say they're not going to assign women to infantry combat units, but they will change the rules and allow women to serve in support jobs closer to the front lines.
Leaders of American Catholics are threatening to challenge the Obama administration over a provision of the new health care law that would require all employers, including religious institutions, to pay for birth control.
Observers say this issue could decide the presidential elections.


text:
To try the thousands of add-ons available here, download Mozilla Firefox, a fast, free way to surf the Web!Close
Welcome to Firefox Add-ons.
Choose from thousands of extra features and styles to make Firefox your own.Close
AMO is getting a new look. Would you like to see it?Close
About me
|User since
|April 8, 2007
|Number of add-ons developed
|8 add-ons
|Average rating of developer's add-ons
|Rated 4 out of 5 stars
Add-ons I've created
Royal Blue Requires Restart
Lots of blue!
BlackX Requires Restart
Black and White.
STEAM Requires Restart
Based off the Steam client from Valve
SKY plus! Requires Restart
The new future is SKY plus!
Strike Requires Restart
Prepare your mind!
My Reviews
Bookmarks Toolbar Button
Rated 3 out of 5 stars
It's cool, but you could right click on the toolbar and uncheck bookmarks toolbar
Great! Rated 5 out of 5 stars
I love Testing. It's such a simple addon!
WOAH! Rated 5 out of 5 stars
Woah. This theme is just amazing! I mean it's so just mind blowingly cool!!
Rated 5 out of 5 stars
This is a great. I am really lazy so this makes life easier! I use back forward and reload. I thought it was just for drawing on firefox, lol, but this is better!This review is for a previous version of the add-on (1.1.2).
Adblock Plus
Rated 5 out of 5 stars
The best addon. It does work for FF3 BETA 5. Just go to their site and right click save as the addon. Then change it to a zip. Open the install file. then find the FF area and change max version to 3.0b5 .Then save it and turn the zip back to .xpi and drag it into the addos box in FF.This review is for a previous version of the add-on (0.7.5.3).
To create your own collections, you must have a Mozilla Add-ons account.


text:
Barbie In The 12 Dancing Princesses (Bilingual)
Barbie In The 12 Dancing Princesses (Bilingual).
By Universal Studios Home Entertainment
We're sorry! This product is not available.
Featured Products
Description & Features+
In "Barbie and the 12 Dancing Princesses", Barbie will dance her way into your heart in this fun and enchanting all-new adventure. Join Barbie as the beautiful Princess Genevieve and her eleven dancing princess sisters as they discover a secret entrance to an amazing, magical world where wishes come true! But when their father is in danger of losing his kingdom, Princess Genevieve and her sisters must work together in order to save the day and their father. They learn that the power of family can overcome all obstacles!.
DVD Special Features: Music Video, Trailer Gallery
Other Special Features: Languages: English and French
Audio Tracks: Dolby Digital 2.0, Dolby Digital 5.1
From the Manufacturer +


text:
The karaoke links here are hand picked and are related only to karaoke. We only list sites that have a direct relation to karaoke so you can be sure you are in the right place to find relevant karaoke links.
- Karaoke Players Info - Karaoke community forums and articles about karaoke players and equipment.
- JustKaraoke - Karaoke player software for windows. Good for home karaoke or hosting a karaoke party using your computer.
- SMK Music Karaoke - KJ from Chicago (Steve Kraslen / KJ / Vocalist). Does fund raising events, special events, nursing homes, private parties, fairs, schools, charity events, reunions, resorts, unique events.
- Music Forum at Music Discussion Forum - You can talk about karaoke here. Share your passion for singing amongst other singers.


text:
Society of Physics Students
Society of Physics Students (SPS) University of South Carolina Chapter
Welcome to the University of SC chapter of SPS! We are a student-run group doing everything fun and physics under the sun:
We have built a trebuchet, a Rube Goldberg machine and volunteered at the South Carolina State Museum. Check out our Facebook page for more fun activities!
You don't have to be a physics major to join. If you like to tinker and are curious about how the world operates, join us and let's find out together!
Image Gallery
Congratulations to the 2016 SPS team for their hard work in the Rube Goldberg competition! Our team took home the first place prize in this year's competition. Click here to check out photos from the event, along with images from previous SPS events.
Useful Information:
- Become a national SPS member
- Astronomy Club at USC
- South Carolina State Museum
- Undergraduate registration
- How to prepare for graduate school
- Important dates and event calendar
President: Krystal Rolon (Physics)
Vice President: Alexander Kirby (Physics)
Secretary: Ryan Geiser (Engineering)
Treasurer: Bryan DeMarcy (Physics)
Faculty Advisor: Dr. Yanwen Wu (Physics) PSC RM 507 (firstname.lastname@example.com)
Current Members:
Zachary Davis (Physics)
Bryan DeMarcy (Physics)
Janus Fraley (Physics)
Ryan Geiser (Engineering)
Trent Hancock (Physics)
Dakota Jones (Computer Science)
Nabil Khan (Engineering)
Alexander Kirby (Physics)
Eric Miller (Math)
Evan Parrotta (English)
Anya Rogers (Physics)
Krystal Rolon (Physics)
Tyler Strampp (Engineering)
Interested in our past and recent activities? Please like and follow us on Facebook!


text:
Separate names with a comma.
Discussion in 'Wii - Backup Loaders' started by ultragunner, Jan 3, 2010.
Can anyone help me how to configure neogamma to guitar hero 5?
Disc or USB? cIOS rev? Neogamma version?
Disc, Cios rev 16, Neogamma version 7 & 8 beta15.
Neogamma doesn't work properly with cIOS rev16, that's your problem
Tried downgrading to cios rev 14. Still the same problem.
Bad dump?
It works fine with Gecko OS 1.9.3 but not with neo Gamma. I am not sure if it is a bad dump. Runs fine in the disc channel.
It's an original copy? If it works through the disc channel why not just boot it through the disc channel?!?!?!
Hehe, you need to download this >>> http://www.mediafire.com/?nodlmqytwiy
That is IOS53, it makes new games such as guitar hero 5 work with neogamma, you might need to download a fix for guitar hero 5 though, I dunno. You install it using wad manager, just put the wad file in a folder called 'wad' on the root of the sd card and load up wad manager in homebrew channel, then select ios53
Come on guys, I'll repeat this nice and slow...
NeoGamma isn't compatible with cIOS249 rev 15 or rev 16!!!!!
So, use rev 14 or 13a.
Does there need to be a sticky stating that NeoGamma does not work with 15 or 16?


text:
Customer Login
Forgot your password? Reset it.
E-Sales Customers: Your old login will not work. If you haven't received an invitation to setup your new account, please register.
Questions? Contact 877.427.7278
At this time, our on-line store is available for U.S. customers only with Net 30 day accounts. For Canadian orders, please contact Baker Transit Parts at 1-800-265-0520 during normal business hours or email firstname.lastname@example.com. All other international inquiries should contact our Florida location at 877-427-7278 or 407-656-7977.
Our parts call center is staffed Monday through Friday from 7:30 a.m. to 8:00 p.m. eastern.


text:
Jeri Muoio was first elected Mayor of the City of West Palm Beach March, 2011.
She was...
With this one, convenient number, there's no more wondering who to call or where to turn when you...
Watch live video of City meetings in real time.
City Commission, CRA, Mayor/Commission Work Session, and Workshops Agendas.
December includes a wonderful variety of events from Letters to Santa to Live Opera!
Dance, Write, Learn
Clematis Room: Large Meeting Room
Hibiscus Room: Large Conference Room
Iris Room: Small Conference Room


text:
Business Development Intern
PAC Software DevelopersBangalore
Internship DescriptionThe candidate should fulfill the following requirements:- 1. A high level of passion to succeed and a strong level of self-motivation. 2. An effective team player with a strong work ethic. 3. Excellent communication skills.
ResponsibilitiesJob Responsibilities:- 1. Professionally and effectively employs sales skills to achieve targeted sales. 2. Build and maintain successful relationships with customers. 3. Identify and develop sources of potential clients. 4. Effectively communicate with clients to gain commitment to purchase. 5. Maintain regular contact with key clients. 6. Effectively communicate with clients via telephone, face-to-face and written communication. 7. Feedback/comments relating to product content and pricing as well as company performance. 8. Provide a weekly schedule of planned activities. 9. Achieve sales activities within specified time scales as directed by Manager.
About Company
PAC Developers is a group of passionate developers. We Believe in Innovation and quality, we don't believe in Comparison we believe in uniqueness and we know that we develop Unique Solutions. We have started this company with a goal to help others to grow their business.


text:
We have to exercise everyday. We have to get more involved in school. We have to have more patience with the kids. We're in it together, we're a team. We have to get happy!
Some quotes from Arizona that are defensive line-centric.
Check out Arizona State coach Todd Graham's man cave.
A closer look at former California coach Jeff Tedford's buyout.
Colorado is set at at least one position: punter.
Will Oregon throw more in 2013?
Oregon State gets spring started with a familiar face on the sidelines, one who can understand odd QB situations.
LB Shayne Skov and RB Tyler Gaffney are back at practice for Stanford.
A UCLA spring practice primer. There are plenty of questions.
Meet USC DE/OLB Jabari Ruffin.
Good news for former Utah DT Star Lotulelei and his NFL draft prospects.
Bob Condotta has five Washington questions for the Huskies second spring session.
More on a Florida QB who has committed to Washington State.


text:
Rosemary Armstrong
- 53 years old
- Date of birth: Jul 29, 1951
- Date of passing: Oct 27, 2004
|Let the memory of Rosemary be with us forever
This memorial website was created in memory of our loved one, Rosemary Armstrong, 53, born on July 29, 1951 and passed away on October 27, 2004. We will remember her forever.
Leave a Tribute:
Invite your family and friends
to visit this memorial:
to visit this memorial:
Subscribe to receive e-mail notifications when others contribute to this memorial.
384 views
Have a suggestion for us?


text:
Goldendoodle Cinemagraph
Jasper was an adorable and fun model for a recent Cinemagraph video shoot. I don't know about you, but his slow blinking gaze makes me sleepy. I filmed and designed a second Cinemagraph of Jasper running the length of the house-wide windows you see behind him. That was a challenging one due to the reflections in the glass, but it worked!
For more pet photography cinemagraphs and other cinemagraphs, see the gallery here.


text:
Dynamo edge out RSL in 7-goal thriller; Sydney & Melbourne fans brawl in the stands
Houston Dynamo 4 – Real Salt Lake 3 (MLS, August 16, 2008) Yura Movsisyan gave RSL the lead after just 3 minutes, Mullan leveled the score in the 13th minute. Javier Morales restored the visitors lead with a low drive only for Brian Ching to draw Houston level again, drilling a left-footed shot past Rimando. The Dynamo then moved ahead with a 30-yard sizzler from Ricardo Clark, and Jaqua netted his first MLS goal to make it 4-1 at half-time. Kenny Deuchar bagged a late consolation for RSL.
Columbus Crew 2 – FC Dallas 1 (MLS, August 16, 2008) Jeff Cunningham opened the scoring, tucking home a pass from Adrian Serioux to notch Cunningham's 100th MLS career goal. But the Crew hit back with two goals in three second half minutes. Brian Carroll sent a bouncing shot past keeper Sala to tie it in the 62nd minute, and Brad Evan's header sealed the win for the Crew.
San Jose Earthquakes 4 – New England Revolution 0 (MLS, August 16, 2008) Bottom club San Jose upset the form book with a thrashing of leaders New England. Irish midfielder Ronnie O'Brien scored twice for San Jose, which also got goals from Scott Sealy and Ryan Johnson.
Sydney FC 0 – Melbourne Victory 0 (A-League, August 16, 2008) The game was marred by some fighting in the stands which had to be dealt with by New South Wales police.


text:
|Home > Roweina
♀ Roweina
What does Roweina mean?
Roweina as a name for girls is of Old German derivation, and the name Roweina means "fame and happiness". Roweina is an alternate form of Rowena (Old German): also possibly (Welsh) "slender and fair".
VARIANTS Rowina, Rowenna, Roweena, RhowenaCREATIVE FORMS
Roweina Violette (R.V.), ..
How popular is Roweina?
Roweina is an uncommonly occurring first name for women. Roweina is an uncommon surname too for both adults and children. (2000 U.S. DEMOGRAPHICS)
Which version is better?
Rowena is the only prominent alternative form of Roweina (NOT RANKED). Other variants, like Roweena, are seldom used. This form of Roweina reached the apex of its popularity 105 years ago (USAGE OF 0.02%). (TOP 2000 NAMES, 2015)
Similar Names
Roweina is alike in pronunciation to Raina▲, Reena, Reina▲, Rena▼, Reyna▲, Rina, Roana, Roanna, Rona, Ronna and Royanna. Other recommended sound-alike names are Coreana (see Corinna), Corvina, Doreina (see Dora), Dorina, Edweena, Edwena, Erwina, Ewelina, Jolena, Jolina, Jonina, Jorgina, Korrina, Lareina, Leina, Lorenna, Montina, Norina, Raelina, Ravenna, Regeena, Reine, Richina, Robbin▼, Robeena, Robena, Robene, Robenia, Robetta (see Roberta), Robin▼, Robina, Robinia, Robyna, Rodina, Roeline, Rohana, Rohanna, Rolene, Rollina, Romaine, Romea, Romeine, Romina▲, Ronnica, Roseann▼, Roseanna, Roselia, Roselina, Rosena, Rosetta▼, Rosina▼, Rosita, Rowan▲, Rowen, Roxanna, Roxeena, Royalina, Rozina, Rufeena, Ruthina, Sheina, Yonina, Yoslina and Zorina. These names tend to be more frequently used than Roweina.See names in meaning and etymology.


text:
I just read that almonds help eliminate belly fat…well, maybe not if you eat them in sweets, but you can splurge once in a while and this is worth it!
If you love chocolate and almonds you don't want to miss this recipe.You only need 3 easy ingredients for this detectible treat! These Salted Dark Chocolate Almonds are irresistible and they aren't that hard to make either! If you are trying to come up with a last minute treat for your Valentine, try these Salted Dark Chocolate Almonds. They will satisfy your sweat tooth and almonds are good for you :)
- 1 cup Semisweet Chocolate Chips
- 2/3 cup whole Almonds
- 1/8 tsp Sea Salt
- Line cookie sheet with parchment paper.
- Melt chocolate by microwaving for 1 minute stirring and repeating until chocolate is smooth and melted.
- Place half the almonds in chocolate and stir to coat.
- Lift out a tablespoonful at a time and place on prepared sheet.
- Sprinkle with sea salt.
- Add remaining almonds and repeat process.
- Allow to set.
Other recipes you may want to try:
Valentine Hearts Rice Krispies Treats
Valentine Coconut Almond Chex Mix
Like these deals? Don't forget to sign up for the Saving Cents with Sense Newsletter to find deals, coupons, and money saving tips in your mailbox each day. You can also follow on Facebook, Twitter, Google+ or Pinterest This site uses affiliate links. Read my disclosure policy here.


text:
New flicks with celebs in interfaith relationships and from interfaith backgrounds, plus their baby news!
Jewish Camp is a valuable way for interfaith families to learn and share in the joy of Judaism in a comfortable, fun and meaningful environment. See which camps identify as welcoming to interfaith families.
The High Holy Days�or, High Holidays as they are also called�consist of two autumn holidays called Rosh Hashanah and Yom Kippur. Learn about the meaning and how to celebrate these holidays.
Connecting Interfaith Families to Jewish Life in Greater Cleveland by providing programs and opportunities for interfaith families to experience Judaism in a variety of venues, meet other interfaith families, and to connect to other Jewish organizations that may serve their needs.
This is an interactive, fun, and low-key workshop for couples who are dating, engaged or recently married. The sessions will give you a chance to ask questions about faith, to think about where you are as an adult with your own spirituality and to talk through what's important to you and your partner.
Supporting rabbis and cantors looking to engage interfaith couples and families in their communities and help them make a stronger connection with Judaism.
A great way for Jewish professionals and volunteers who work with and provide programming for people in interfaith relationships to locate resources and trainings to build more welcome into their Jewish communities; connect with and learn from each other; and publicize and enhance their programs and services.
This blog is written by IFF staff and ranges from reactions to news, personal opinions and resources or guides for couples, families or program providers.
Epstein Hillel SchoolSchool/EducationMarblehead, MA01945 United States3 MembersGreater Boston Greater Boston
Kahal B'rairaSynagogueCambridge, MA02138 United States5 MembersGreater Boston Greater Boston
KeshetAdvocacyBoston, MA02130 United States8 MembersGreater Boston
JCDS, Boston's Jewish Community Day SchoolSchool/EducationWatertown, MA02472 United States2 MembersGreater Boston Greater Boston
Interfaith Families of Greater PhiladelphiaOutreachMid City West, PA19103 United States2 MembersPhiladelphia
Perelman Jewish Day SchoolSchool/EducationMelrose Park, PA19027 United States2 MembersPhiladelphia
Shir HadashSynagogueWheeling, IL60090-4750 United States3 MembersChicagoland
Sunday School for Jewish StudiesSchool/EducationNewton, MA02459 United States6 MembersGreater Boston
Sholem CommunityArts & Culture - Los Angeles, CA90066 United States1 Member
The Alfred & Adele Davis AcademySchool/EducationSandy Spgs, GA30350 United States1 MemberAtlanta Atlanta
Copyright © 2015 InterfaithFamily.com, Inc. Privacy Policy


text:
Programs for children go on year-round at the Library. Adults are expected to stay with children throughout all programs.
Toddler Time
Children get a fun and active introduction to the Library with twenty minutes of stories, songs and movement, every Monday at 9:15 in eight-week sessions. There's no need to sign up, but children should be at least eighteen months old. The 2017 schedule begins 11 September.
Preschool Storytime
Preschoolers ages three to five are invited to sign up for a weekly half hour of story fun and a new craft project or coloring page every Wednesday, with a variety of readers from among Library staff and volunteers. Storytimes start promptly at 10 AM year-round with short breaks between sessions. Registration is not required, but those who do will have a personalized certificate hanging up in the Library, to stick their attendance stickers on. Children must be accompanied by an adult throughout the program. The 2017 schedule will begin 6 September.
Play K
Children age 4 ½ to 6 years old spend a weekly hour enjoying learning the social, behavioral and motor skills they'll need as kindergarteners. Stories, games and "playscapes" featuring a variety of educational (and entertaining) toys follow a theme that changes every week. More information available HERE.
Summer Reading Club
Held each summer for readers ages 6 to 12. Just because the school year is ending, that doesn't mean the learning has to stop. Students who don't continue reading over the summer are likely to lose ground. Make reading fun with our Summer Reading Club.
Evening Programs
Most children's programs are scheduled for Thursday evenings at 6:30 PM. A half hour of stories is followed by a craft project. Staff and volunteers do the reading, sometimes with a theme, sometimes just "reader's choice." Check our web calendar for details.
Time Out For LEGO®!
The second Thursday of each month is Family Night with the Library's large collection of LEGO® bricks and accessories. Come in at 6:00 PM with imagination at the ready, for an hour of LEGO® play.


text:
Sara's TTC #1 Journal
View Single Post
May 8th, 2013, 10:14 AM
Super Mommy
Join Date: Mar 2013
Location: North Texas
Posts: 175
I am not one to handle stress well at all. It eats away at me. So right now I am still in a funk over the TTC stuff and also now trying to figure out when I have to fly from Dallas to Boston to meet movers who will be packing and moving my grandmother's apartment (she is already here now). I will either have to fly out the weekend of May 18th or sometime in June. I am waiting to hear back from the landlord on whether they will release her from her lease, if June will be covered by security or not at all, etc. I hate having a bunch of stuff to do on weekends. I end up feeling like I am running around and not relaxing. I have to stay at my parents' house Thursday night and Friday morning to care for my aunt and grandmother while my mom has a full body PET scan. Then Mother's day weekend needs to be split between DH's mom and my mom. My mom would completely use it against me in the future if I didn't go over (I love her, but she is definitely manipulative). I am hoping that DH's mom isn't going to want any special attention. Then my 30th birthday is over memorial day weekend. I am tempted to just buy a cake for myself and stay home cuz I really don't feel like celebrating at this point, not to mention that most of our friends won't be around at all.
I need to see my therapist soon. I know when I feel that pit in my stomach, I have been bottling way too much emotion inside.
Lucas Xavier is here! Born 4/24/2014 at 10:47pm
7 pounds 6 ounces
20.5 inches long
View Public Profile
Find all posts by sarav


text:
Activate Creature Power!
Wild Kratts, a top rated show on PBS, follows the adventures of Chris and Martin Kratt as they encounter wild animals, and combine science education with the fun and adventure of traveling to animal habitats around the globe.
Each Wild Kratts epsiode features a mix of live action and animation to bring children into the secret lives of extraordinary creatures.
Children learn about a different animal species every show and are able to become that animal through the superpowers of the Kratts Brothers and their Creature Power Suits!


text:
Our Blue Crew
Recently our local Chick-Fil-A had a free chicken strip night if you sported your Colts Blue. We're all about an almost free dinner for six! The Blue Crew Bus was there, making it a "family picture moment".
Hopefully our beloved Colts will have a better showing this Sunday as we take on the Minnesota Vikings. Go Blue!


text:
|Home | About | Journals | Submit | Contact Us | Français
Hepatocellular carcinoma (HCC) is a leading cause of death worldwide. Using cDNA microarrays to characterize patterns of gene expression in HCC, we found consistent differences between the expression patterns in HCC compared with those seen in nontumor liver tissues. The expression patterns in HCC were also readily distinguished from those associated with tumors metastatic to liver. The global gene expression patterns intrinsic to each tumor were sufficiently distinctive that multiple tumor nodules from the same patient could usually be recognized and distinguished from all the others in the large sample set on the basis of their gene expression patterns alone. The distinctive gene expression patterns are characteristic of the tumors and not the patient; the expression programs seen in clonally independent tumor nodules in the same patient were no more similar than those in tumors from different patients. Moreover, clonally related tumor masses that showed distinct expression profiles were also distinguished by genotypic differences. Some features of the gene expression patterns were associated with specific phenotypic and genotypic characteristics of the tumors, including growth rate, vascular invasion, and p53 overexpression.
Hepatocellular carcinoma (HCC) is the most common liver malignancy and among the five leading causes of cancer death in the world. Virtually all HCCs are associated with chronic hepatitis B virus (HBV) or hepatitis C virus infections (Beasley, 1988 ; Hasan et al., 1990 ), but the molecular nature of this association is poorly understood. HCC treatment options remain limited. Surgical resection is considered the only "curative treatment" (Lin et al., 1987 ), but >80% of patients have widespread HCC at the time of diagnosis and are not candidates for surgical treatment. Among patients with localized HCC who undergo surgery, 50% suffer a recurrence (Okuda et al., 1984 ). Standard clinical pathological classification of HCC has limited value in predicting the outcome of treatment. Clearly, molecular markers for early and accurate diagnosis and classification of HCC would address an important medical need.
The phenotypic diversity of cancer is accompanied by a corresponding diversity in gene expression patterns (Perou et al., 1999 ; Alizadeh et al., 2000 ; Perou et al., 2000 ; Ross et al., 2000 ; Welsh et al., 2001 ). Herein, we describe a systematic characterization of gene expression patterns in human liver cancers. We used cDNA microarrays containing 23,000 clones, representing ~17,400 human genes, to study tumor and nontumor liver tissues from HCC patients. Our aim was to characterize the gene expression programs associated with HCC as a step toward a better understanding of the molecular pathophysiology, and better methods for detection, diagnosis, and classification of HCC.
All patients participating in this study gave informed consent before surgery. All tissues were surgically resected, snap frozen in liquid nitrogen within 0.5 h after the resection, and stored at −80°C. In most cases, both tumor and adjacent nontumor tissues were collected. A portion of each specimen, ~0.5–1 cm3, was sampled. Each sample was dissected into three equal slices. One was used for RNA extraction, one for genomic DNA iolsation, and the other processed for histological examination. Each histological slide was independently reviewed by two pathologists. Total RNA was extracted with RNeasy kit (QIAGEN, Valenica, CA), and mRNA was isolated from total RNA by using FastTrack (Invitrogen, Carlsbad, CA) or Poly-(A)Pure (Ambion, Austin, TX) mRNA purification kit. mRNA from cell lines was purified directly with FastTrack (Invitrogen) kit. We combined mRNA from the following cells, in equal quantities, to make the reference pool: HepG2, SNU398, SNU1, Jurkat, RPMI, and CCD-1070SK.
cDNA clones (23,075), representing ~17,400 genes, were mechanically printed onto treated glass microscope slides, as described previously (Perou et al., 2000 ) (http://cmgm.stanford.edu/pbrown/array.html). Approximately 18,700 of the clones were obtained from Research Genetics, and 4,300 clones were obtained directly from Cancer Genome Anatomy Project (http://www.ncbi.nlm.nih.gov/ncicgap/). The hybridizations were performed as described previously (Alizadeh et al., 2000 ). A detailed protocol is available at http://cmgm.stanford.edu/pbrown/protocols/5_hyb_human.html. In brief, 2 μg of sample mRNA and 2 μg of reference mRNA were labeled with Cy5-dUTP and Cy3-dUTP (Amersham Biosciences, Piscataway, NJ), respectively, by using Reverse Transcriptase (Invitrogen) for 2 h at 42°C. The two labeled cDNA probes were separated from unincorporated nucleotides by filtration, mixed, and hybridized to microarray at 65°C overnight. After hybridization, each microarray was washed with 2× SSC, 0.03%SDS for 5 min at 65°C then with 1× SSC for 5 min and 0.1× SSC for 5 min, both at room temperature. The array was then scanned using GenePix 4000A microarray scanner (Axon Instruments, Union City, CA). Array CGH was performed as described previously (Pollack et al., 1999 ). The detailed protocol is available at http://cmgm.stanford.edu/pbrown/protocols/4_genomic.html.
Primary data collection and analysis were carried out using GenePix Pro 3.0 (Axon Instruments). Areas of the array with obvious blemishes were manually flagged and excluded from subsequent analysis. The raw data were deposited into Stanford Microarray Database (Sherlock et al., 2001 ) at http://genome-www4.stanford.edu/MicroArray/SMD/index.html. All nonflagged array elements for which the fluorescent intensity in each channel was >1.5 times the local background were considered well measured. Genes for which <75% of measurements across all the samples in this study met this standard were excluded from further analysis. We selected for further analysis genes whose expression level differed by at least threefold, in at least four samples, from their mean expression level across all samples. We applied a hierarchical clustering algorithm both to the genes and arrays by using the Pearson r as the measure of similarity, and average linkage clustering, as described previously (Eisen et al., 1998 ). The results were visualized and analyzed with TreeView (M. Eisen; http://rana.lbl.gov). We used two-sample Welch t statistics (allowing for unequal variances) to identify genes that were differentially expressed in two sets of samples. The statistical significance of the differential expression of any gene was assessed by computing a p value for each gene, representing the chance of observing a test statistic at least as large (in absolute value) as the value actually obtained. No specific parametric form was assumed for the distribution of the test statistics. To determine the p value, we used a permutation procedure in which the class labels of the samples were permuted 500,000 times, and for each permutation, two-sample t statistics were computed for each gene. The permutation p value for a particular gene is the proportion of the permutations (out of 500,000) in which the permuted test statistic exceeds the observed test statistic in absolute values. Any gene for which this p value was <0.001 was considered to be differentially expressed. The corresponding "per-family type 1 error rate" (PFER), that is, the expected number of false positives for such a multiple test procedure is PFER = number of genes × 0.001. Alternatively, the Benjamin & Hochberg procedure was applied to control the "false discovery rate" (FDR), or expected proportion of false positive among the genes declared differentially expressed.
Immunohistochemistry was performed as described previously (Perou et al., 1999 ). Antibody MY10, for CD34, was used at 1:10 dilution (BD Biosciences, San Jose, CA). Antibody DO-7, for p53, was used at 1:100 dilution (DAKO, Carpinteria, CA).
Genomic DNA was extracted using the DNeasy extraction kit (QIAGEN), digested overnight with HindIII or EcoRI, and resolved by electrophoresis through a 1% agarose gel. After depurination, denaturation, and neutralization, the gel was transferred overnight with 10× SSC to a nylon Hybond-N+ membrane (Applied Biosystems, Foster City, CA). HBV-specific sequences were detected by hybridization with a polymerase chain reaction-amplified copy of the complete HBV genome, from blood of a patient with HBV infection, labeled with fluorescein by random primed labeling (Applied Biosystems). Detection was performed with anti-fluorescein antibody conjugated with horseradish peroxidase, followed with enhanced chemiluminescence development (Applied Biosciences) and exposure to x-ray film (Eastman Kodak, Rochester, NY).
We characterized genomic expression patterns in >200 samples, including 102 primary HCC (from 82 patients), 74 nontumor liver tissues (from 72 patients), seven benign liver tumor samples (three adenoma and four FNH), 10 metastatic cancers, and 10 HCC cell lines. The complete data are available at http://genome-www.stanford.edu/hcc/Figures/ArrayInformation.htm.
As a first step to organize the results for visual display and for further analysis, we used a hierarchical clustering algorithm (Eisen et al., 1998 ) to group the genes, as well as the samples, on the basis of similarity in their expression pattern. The results for the 3180 genes (represented by 3964 cDNAs) with the greatest variations in expression in 82 HCC and 74 nontumor liver tissues samples are displayed in Figure Figure1.1. To help provide a framework for interpretation of the expression patterns observed in the clinical samples, we compared these results with the gene expression patterns in 10 HCC cell lines. The expression data for the cell lines are displayed to the left of the main panel in Figure Figure1. 1.
Several features of the gene expression patterns are evident in Figure Figure1.1. First, based solely on their gene expression patterns, the clinical samples could be divided into two major clusters, one representing HCC samples, and the other, with a few exceptions, representing nontumor liver tissues. Second, expression patterns varied significantly among the HCC and nontumor liver samples. Third, samples from HBV-infected, hepatitis C virus-infected, and noninfected individuals were interspersed in the HCC branch.
Close-up views of clusters of genes whose expression covaries in this set of samples are shown in Figure Figure2.2. One cluster of genes was highly expressed in HCC samples compared with nontumor liver tissues. It includes the "proliferation cluster" (Figure (Figure2A),2A), comprised of genes whose functions are required for cell cycle progression and whose expression levels correlate with cellular proliferation rates. Most of the genes in this cluster are specifically expressed in G2/M phase (Cho et al., 2001 ). As expected, liver cell lines, continuously proliferating in culture, also expressed the genes in this cluster at high levels. Genes encoding ribosomal proteins were also relatively highly expressed in HCC, an expression pattern characteristically observed in growing cells. Other genes not known to be related to cell proliferation or translation also showed consistently elevated expression in HCC. These genes are implicated in a variety of cellular process, including cell signaling, transcriptional regulation, RNA splicing, protein degradation, and cell adhesion. The functional significance of their elevated expression in HCC remains to be elucidated.
Among the genes that were expressed at lower levels in HCC than in nontumor liver tissues, most seemed to be genes specifically expressed in differentiated hepatocytes (Figure (Figure2B),2B), including genes encoding liver-specific metabolic enzymes and many plasma proteins, including clotting factors, apolipoproteins, and complement proteins. When expanded in vitro, HCC cell lines have been found to lose expression of most "liver-specific markers." These data confirm that many of the characteristic molecular features of normal hepatocytes are clearly also deficient in the tumor themselves.
Both normal liver and liver tumors are complex tissues composed of diverse specialized cells. Distinct patterns of gene expression seemed to provide molecular signatures of several specific cell types. Expression of two clusters of genes associated with T and B lymphocytes, respectively, presumably reflects lymphocytic infiltration into liver tissues (Figure (Figure2,2, C and D). In nontumor liver tissues, their expression correlated with viral infection, perhaps reflecting the chronic inflammatory response to the infection.
The expression patterns of two distinct clusters of genes seem to reflect variation in the density and composition of stromal cells (Figure (Figure2,2, E and F). Several of the genes in the second group, including LTBP2, CSPG2, and TIMP1, have been shown to be expressed in activated stellate cells in response to liver injury (Gressner et al., 1994 ). Variation in expression of this cluster of genes may therefore reflect variation in the distribution of activated stellate cells in the tissues.
A cluster that included several genes typically expressed in endothelial cells, including CD34, RGS5, and THY1, was expressed at a higher level in HCC than in nontumor liver tissues (Figure (Figure2G).2G). CD34 is expressed in endothelial cells in veins and arteries but not in the endothelial cells of the sinusoids in nontumor liver. However, it is strongly expressed in the endothelial cells that line the sinusoid-like vessels in the HCC samples (Figure (Figure2I),2I), presumably reflecting disruption in HCC of the molecular program that normally regulates blood vessel morphogenesis in the liver. A second cluster of genes characteristically expressed in endothelial cells, including VWF, hevin, and VE-cadherin (Figure (Figure2H),2H), showed variable expression among the tissue samples and no systematic difference in expression between HCC and nontumor liver tissues. These two groups of genes may therefore represent two distinct types of endothelial-like cells in liver.
Previous work has suggested that the gene expression pattern of a tumor can provide a distinctive molecular portrait recognizable in successive samples over time and in metastases (Perou et al., 2000 ). How distinctive and consistent are the gene expression patterns in individual hepatocellular carcinomas? We investigated whether samples from multiple sites in a single HCC tumor, or multiple separate tumor nodules in one patient, would share a recognizable gene expression signature. We analyzed 102 HCC samples from 82 patients by hierarchical clustering based on the overall similarity in their pattern of expression of 2640 genes (represented by 3271 cDNA clones) (Figure (Figure3A).3A). With a few instructive exceptions, all the tumors samples from each patient clustered together.
To further examine the relationships among multiple tumor samples from individual patients, we calculated the pairwise r for all pairs of samples and displayed the results in Figure Figure3B.3B. For SF1, SF34, SF35, and HK62, each primary tumor was sampled multiple times. For each of these tumors, the pattern of gene expression in a given tumor sample was more highly correlated with the pattern seen in the other samples from the sample patient than with any of the other tumors we analyzed. Every tumor therefore had a distinctive and characteristic gene expression pattern, recognizable in all samples taken from different areas of the same tumor.
Multiple discrete tumor masses were obtained from six patients. In three of these patients, HK63, HK64, and HK66, the multiple tumors shared a distinctive gene expression pattern. In the three other patients, HK65, HK67, and HK85, the expression patterns varied between tumor nodules, and the difference provides new insights into the sources of variation in the molecular and biological characteristics of cancers.
Recent studies have shown that the gene expression patterns in samples of a given tumor taken at different times or from different sites are typically much more similar to one another than are the expression patterns observed in tumors of the same type in different patients (Perou et al., 2000 ). Do the distinctive expression patterns characteristic of each tumor reflect the individuality of the tumor, or are they determined by the patient in whom the tumor arose? Analysis of the multifocal hepacellular carcinomas provides an opportunity to address this important question.
The expression patterns observed in the two tumor nodules from patient HK85 were not significantly more similar than those of an arbitrary pair of tumors from different patients. These two tumor nodules were each 2 cm in diameter and were separated by a distance of 7 cm. Southern analysis of the HBV integration sites showed that T1 and T2 had distinct integration patterns (see supplementary information), strongly suggesting that they were clonally independent tumors.
The tumor nodules from patient HK65 were immediately adjacent, but grossly separated foci. Each tumor mass was ~2 cm in diameter. The gene expression patterns observed in tumor nodules HK65-T2 and HK65-T4 were more similar to each other than either was to the pattern observed in HK65-T1. The gene expression patterns in the tumor nodules in this patient showed an intriguing relationship to p53 activity. In normal cells, p53 is so rare that the protein usually cannot be detected by standard immunohistochemical staining. Positive p53 staining generally indicates a mutant form of p53 gene in HCC tissues (Hsu et al., 1993 ), probably because the mutated p53 protein is more stable and accumulates in the nuclei. p53 was undetectable by immunohistochemical staining in T2 and T4, but it was readily detected in the nuclei of tumor cells in T1 (Figure (Figure3C).3C). To investigate the clonality of these tumor nodules, we performed Southern analysis of the HBV integration site on T1 and T2 (see supplementary information). The HBV integration sites in these tumors seemed indistinguishable, suggesting they arose from the same clone. We used microarray CGH to characterize the patterns of chromosomal amplifications and deletions in T1 and T2 (see supplementary information). Although the chromosomal changes in T1 seemed, by this assay, generally similar to those seen in T2, T1 showed some distinct patterns, including partial or complete loss of a copy of chromosomes 5q, 9p, 12, and 22. All these data suggest that despite their common clonal origin, the genome of T1 is distinctly different from that of T2 and T4, presumably accounting for the differences in gene expression pattern.
In patient HK67, T1 was the main tumor mass, measuring 8 cm in diameter. T2 and T3, measuring 1 and 3 cm, respectively, were satellite nodules in a different liver lobe. expression patterns of T2 and T3 were remarkably similar, but only distantly related to the pattern observed in T1. Although p53 was uniformly detectable by immunohistochemistry in the nuclei of tumors cells in T2 and T3, the immunostaining pattern observed in T1 was heterogeneous. In most areas, p53 staining was undetectable, but in some patches of this tumor, p53 staining was readily detected in >50% of the tumor cell nuclei (Figure (Figure3D).3D). Genes associated with proliferation were expressed at significantly higher levels in T2 and T3 than in T1. Array CGH analysis revealed very similar patterns of chromosomal amplifications and deletions in T1 and T2, including rare chromosomal abnormalities (Wong et al., 1999 ; Shiraishi et al., 2001 ) such as amplification of 19q, and deletion of 15q and the centromere region of 22 (see supplementary information), suggesting a common clonal origin. However, T2 was distinguished from T1 by an additional deletion of chromosome 13. The data suggest that at least some of the tumor cells of T1 are genotypically unstable, resulting in genotypic heterogeneity among the cells in this tumor. In view of their smaller size, faster proliferation, and homogeneity with respect to p53 staining, T2 and T3 are probably subclones derived from T1. The p53 mutation and other genetic changes apparently provided a growth, survival, or migration advantage that enabled these clones to outgrow and metastasize.
Taken together, these results suggest that each independently arising tumor is distinguished from other tumors of the same pathological type, whether they arise in the same patient or different patients, by a distinctive gene expression program that reflects the cell of origin and the unique sequence of genetic events. Moreover, multiple clonally related tumor samples in the same patients can show different gene expression patterns due to divergent histories of mutations or chromosomal alterations.
Mutations in the p53 gene are a common finding in HCC and may play a key role in pathogenesis. To investigate the relationship between p53 mutations and the gene expression program in HCC, 59 HCC specimens were examined by immunohistochemical staining for p53 protein. Positive p53 staining, which has been noted to correlate with p53 mutation or inflammation in HCC (Hsu et al., 1993 ), was found in 23 of the tumors analyzed. We found no apparent correlation between p53 staining and histological evidence of inflammation in our series.
Among the 59 samples we analyzed, we found characteristic differences in gene expression patterns between the tumors with positive p53 staining and those with negative p53 staining. We identified 121 genes whose expression level was correlated with p53 staining, with p < 0.001 by two-sample Welch t statistics (Figure (Figure4).4). Of these 121 genes, 86 were more highly expressed in tumors with positive immunostaining for p53. Most of these 86 genes belonged to the proliferation cluster, i.e., their expression was strongly associated with proliferation, suggesting that mutation of p53 might be a key pathogenetic event leading to accelerated cell proliferation during HCC tumorgenesis.
Most of the 35 genes that were characteristically expressed at lower levels in the HCC samples with positive p53 staining are noteworthy for their specific expression in differentiated hepatocytes, presumably reflecting a tendency for tumors cells with p53 mutations to be poorly differentiated (Caruso and Valentini, 1999 ). Interestingly, one of these genes, MST, also called hepatocyte growth factor-like protein, has been reported to be induced by p53 expression (Zhao et al., 2000 ), raising the possibility of a role for this putative growth factor in p53-dependent regulation of hepatocyte differentiation.
Vascular invasion seems to have an important role in tumor spread and metastasis. All tumor samples were classified by histopathological evaluation as either positive or negative for vascular invasion. We identified 91 genes whose expression levels were significantly correlated with the presence or absence of vascular invasion by two-sample Welch t statistics (p < 0.001) (Figure (Figure5). 5).
Sixty-one of these genes were expressed at higher levels in tumors with vascular invasion than in tumors without vascular invasion. Most of these genes had functions and expression patterns associated with cell proliferation. One of the few genes in this set that seems to be unrelated to cell proliferation encodes matrix metalloproteinase (MMP) 14. MMP family members are involved in the breakdown of extracellular matrix and may play important roles in invasion and metastasis (Liotta et al., 1980 ; Arii et al., 1996 ; Hayasaka et al., 1996 ). MMP14 may have a direct role in activation of MMP2 (Sato et al., 1994 ), which in turn has been shown to be related to an invasive phenotype and poor prognosis in HCC (Murakami et al., 1999 ). The association of MMP14 expression with vascular invasion highlights the possible importance of these MMPs in the progression of HCC and underscores their potential as therapeutic targets.
Most of the genes that were expressed at lower levels in the tumors with vascular invasion were "liver specific," consistent with the classical pathological observation that poorly differentiated HCC tumors tend to be more aggressive and invasive (Ng et al., 1995 ). One of the few genes in this group that did not belong to the liver-specific cluster encodes the metalloprotease ADAMTS1, which was recently shown to inhibit endothelial cell proliferation and to have antiangiogenic activity (Vazquez et al., 1999 ). Although vascular invasion and angiogenesis have traditionally been viewed as independent properties of a tumor, a recent study has suggested an association between vascular invasion and intratumoral angiogenesis (Maehara et al., 2000 ). The function and regulation of ADAMTS1, and its possible role in suppressing vascular invasion and angiogenesis, warrant further investigation.
Many tumors, particularly those arising in the gastrointestinal tract, have a propensity to metastasize to the liver. We examined several metastatic lesions in the liver. The expression patterns of 10 randomly selected HCC samples and 10 liver metastases of other cancers were analyzed by hierarchical clustering as shown in Figure Figure6.6. The HCC samples and the metastatic cancers clustered into two distinct groups, based on differences in their patterns of gene expression. Although some of the HCC samples were poorly differentiated and expressed the genes of the liver-specific cluster at very low levels compared with either normal liver or well-differentiated HCC, the genes of the liver-specific cluster were consistently expressed at higher levels in HCC than in tumors of nonliver origin. Metastatic cancers originating from the same tissue typically clustered together, expressing genes characteristic of the cell type of origin. For example, the four samples of metastatic colon adenocarcinoma clustered together, distinguished in part by their abundant expression of the keratin 17, keratin 19, and mucin 1 genes. In contrast, a metastatic carcinoid tumor from the colon expressed genes commonly associated with neurons and neuroendocrine cells, including syntaxin 1A and syntaxin binding protein 1. The sample labeled HK17, diagnosed as undifferentiated adenocarcinoma, expressed a distinctive set of genes. Due in part to the small number and limited diversity of the non-HCC tumors in this study we cannot pinpoint the site from which this tumor arose. We are optimistic, however, that systematic comparison of the gene expression pattern in a metastatic tumor of uncertain origin with the expression patterns observed in a large, diverse sample of tumors and normal tissues will allow reliable recognition of the primary tumor of origin.
The molecular pathogenesis of HCC is still poorly understood, and its clinical course can vary widely. Systematic analysis of global gene expression programs in human cancers can lead to new insights into pathogenetic mechanisms and improved prediction of clinical behavior (Golub et al., 1999 ; Alizadeh et al., 2000 ; Perou et al., 2000 ). A recent report analyzed gene expression patterns in 20 HCC samples (Okabe et al., 2001 ), by directly comparing tumor to nontumor liver tissue from the same patient. The studies noted the elevated expression of proliferation-associated genes in the tumors, and suggested that expression of specific genes could be associated with the viral etiology of the tumor, vascular invasion, and other features. The interpretation of these results was complicated, however, by the fact that the gene expression patterns in the nontumor liver samples from different patients can vary significantly, affected by the viral infection and degree of cirrhosis (Figure (Figure1).1). Thus, the tumor-specific variation in the expression patterns could not be distinguished from variation due to differences in the corresponding nontumor liver samples.
In this study, we used a common reference RNA sample as an internal standard for measurement of expression in each clinical specimen, allowing systematic comparisons to be made among all of our tumor and nontumor tissues and cell lines. HCC and nontumor liver samples were readily divided into two separate major branches when these tissues were hierarchically clustered based on their gene expression patterns, reflecting the consistent differences between the gene expression program in HCC and nontumor liver tissues. Of the 3180 genes that showed the greatest variation in expression among all the samples we studied (Figure (Figure1),1), ~1640 genes were differentially expressed in HCC vs. nontumor liver samples (p < 0.01 by Student's t test with Bonferroni correction; see supplementary information).
Primary HCC was readily distinguished from tumors metastatic to liver based on differences in global gene expression patterns. Metastatic tumors from the same primary site shared distinctive gene expression patterns that seemed to be related to their normal cellular progenitor. Metastatic tumors of unknown primary origin are not rare. Classification of these tumors according to the primary tumor of origin has important implications for treatment. Our preliminary results provide encouraging support for the hypothesis that tumors of unknown primary could be identified by comparing their gene expression patterns with the profiles of diverse malignant and normal tissues.
As observed for breast cancers (Perou et al., 2000 ), lymphomas (Alizadeh et al., 2000 ), and other cancers (our unpublished data), the gene expression pattern of each HCC seems to provide a distinctive molecular portrait of that tumor, several features of which are statistically associated with specific phenotypic features of the tumors. Multiple tumor samples from the same patient typically share recognizable and distinctive features in their gene expression patterns. An important question raised by this recurrent observation is whether the differences in gene expression patterns reflect the individuality of the tumors or the patients in whom the tumors arise. The results of this study provide a partial answer. In a few cases, separate tumors from a single patient showed dramatic differences in their gene expression patterns. We found that the differences are likely due either to independent clonal origins of separate HCCs in the same patient (HK85), or to divergent genotypic evolution of clonally related tumors (HK65 and HK67). Therefore, the differences that distinguish the gene expression programs of individual tumors of the same histological type seem primarily to arise during the development and progression of the tumors, rather than reflecting underlying differences between the patients in whom the tumors arose.
Extensive variation in histology and cell morphology is a frequent feature of cancer. The microscopic heterogeneity in p53 protein levels observed in one of the tumors were analyzed, HK67, provides an informative example (Figure (Figure3D).3D). The RNA samples were analyzed in this study were isolated from macroscopic tumor samples ~1 cm3 in size, a scale too large to allow resolution of the differences in gene expression to accompany the differences in p53 activity (and presumably other genotypic variation) represented in this heterogeneous tumor sample. However, the differences in the expression patterns observed between the largest tumor mass in patient HK67, tumor T1, and tumor nodules T2 and T3, presumed to be intrahepatic metastases from T1, support the hypothesis that the cellular heterogeneity observed at the histological level is accompanied by corresponding heterogeneity in the gene expression patterns. Clearly, this important phenomenon warrants further study by using methods such as laser-capture microdissection and immunhistochemistry, which can allow molecular variation at the level of single cells to be characterized in greater detail.
Among the genes that were characteristically highly expressed in HCC, those whose products are membrane associated or secreted are of particular interest for their potential as therapeutic targets or as serological markers for early detection. α-Fetoprotein has been widely used as the serum marker for HCC diagnosis and follow-up. However, it is elevated in only 50% of HCC (Johnson, 2001 ) (Figure (Figure1). 1). Additional, and better, serological markers are clearly needed. In this study, we were able to identify hundreds of genes whose expression was more consistently elevated in HCC than was α-fetoprotein (see supplementary information). Using a DNA microarray method for identification of membrane-associated transcripts (Diehn et al., 2000 ) and sequence analysis for transmembrane domain or signal peptides (Kyte and Doolittle, 1982 ; Nielsen et al., 1997 ), we were able to distinguish a subset of these genes whose products are likely to be either membrane bound or secreted (Diehn, unpublished data). By raising antibodies against the products of these genes, we hope to identify new serum markers for detection and diagnosis of HCC, and perhaps new candidate targets for treatment.
Supplementary information is available on the authors' World-Wide Web site (http://genome-www.stanford.edu/hcc).
We thank the members of the Stanford Microarray Facility and Stanford Microarray Database, especially Mike Fero, Gavin Sherlock and Tina Hernandez-Boussard. We thank B. Strausberg at NCI for CGAP clones. We also thank the members of the Asian Liver Center at Stanford, especially Wijan Prapong and Ann Vu-Nguyen. We are grateful for the members of the Brown and Botstein laboratories for helpful discussions and comments on the manuscript. Research at Stanford was supported by grants from the National Cancer Institute to P.O.B and D.B., by a grant from the H. M. Lui Foundation to S.S., and by the Howard Hughes Medical Institute. The work of S.T.C. and S.T.F. was supported in part by a grant from the Sun Chieh-Yeh Research Foundation for Hepatobiliary and Pancreatic Surgery, HKU. X.C. is a Howard Hughes fellow of the Life Science Research Foundation. P.O.B. is an Associate Investigator of the Howard Hughes Medical Institute.
Article published online ahead of print. Mol. Biol. Cell 10.1091/mbc.02–02–0023. Article and publication date are at www.molbiolcell.org/cgi/doi/10.1091/mbc.02–02–0023.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
Duration: 2min 50sec Views: 37 576 Submitted: 4 years ago Submitted by:
Description: British brunette Paige Turnah stars in a marvelous little gonzo flick with ass worship. She flaunts her silky buns for the camera while playing with her black panties and bending over. Her huge tits she keeps for herself gives her booty up generously.
Channel: Brazzers Network
Pornstars: Paige Turnah


text: This is on AOL today. The article was about the 10 brands they expect to disappear soon. They were right on about 8 of the 10 last set, so.... Crocs In late 2007, Crocs' (CROX) shares traded at more than $72. Now they change hands at well below $2. At the end of March, Crocs got a six-month extension of a critical credit facility. According to Reuters, "Crocs Inc averted a cash crunch by winning an 11th-hour credit facility extension with a California bank, but analysts say the jury is still out on whether the struggling brand can turn around." Two weeks before the credit extension, the company's auditors gave the firm a "going concern" letter, an indication that there would be reasonable chance that Crocs would make it another year. In the fourth quarter of 2008, Crocs lost $43 million after making $55 million in the same period the year before. Revenue fell from $225 million in the last quarter of 2007 to $126 million. Crocs won't make it through the year. I'm a New Balance gal myself, but if I loved Crocs, I think I'd be stocking up!


text:
Notice Issued to YSRCP MLAs
Assembly Privilege Committee issues notice to 12 YSR Congress MLAs for disrupting the proceedings of the House during the Winter Session. All of these MLA's are asked to appear before the Privilege Committee on October 25th & 26th to give an explanation.
List of YSR Congress MLAs who are given the Privilege Committee Notice:
(1) Kodali Nani, (2) Chevireddy Bhaskar Reddy, (3) Dadisetty Raja, (4) Korumutla Srinivasulu, (5) Chirla Jaggireddy, (6) Rachamallu Sivaprasadar Reddy, (7) Pinnelli Ramakrishna Reddy, (8) Alla Ramakrishna Reddy, (9) Muthyala Nayudu, (10) Sunil Kumar, (11) Kiliveti Sanjeevaiah, (12) Kambala Jogulu.
YSRCP MLA Y Visweswara Reddy spoke on this and Questioned if there is anything wrong in fighting for the special status. He clarified that not just 12 MLAs but even if the assembly suspended all of their members too they will continue raising their voice against wrong doings of the government.


text:
Welcome to WebmasterWorld Guest from 18.104.22.168
Forum Moderators: open
Any advice is much appreciated.
Thanks in advance.
joined:Nov 12, 2005
votes: 0
>> so the question is which processor is really faster
In terms of CPU it's the Asus Notebook.
There are other things you should be looking at with these notebooks, as well, though. Which one has the "better bang for your buck" value? Which one is set up for your needs better? Graphics card? What kind? RAM? Take these all into account when purchasing a PC.


text:
Sign In
Fan Fic
CBM Index
Star Trek
STAR TREK INTO SPECULATION: Who IS John Harrison?
There's been a lot of speculation on who Benedict Cumberbatch is playing in Star Trek Into Darkness, with the most prevalent name being Gary Mitchell. This week it was announced he's actually playing someone named John Harrison, which triggered this particular thought.
Filed Under: "
Star Trek
Quite some time ago, Karl Urban let slip that Benedict Cumberbatch was doing a great job as Gary Mitchell in the Star Trek sequel, which became an oft-repeated headline across the Internet. It seemed as though the actor had really screwed up, breaking a vow of secrecy that everyone associated with the new film — and probably their ancestors and descendants as well if JJ Abrams had his way — had taken. But would Urban REALLY make such an elementary mistake?
So it seemed that Gary Mitchell was the likely antagonist of the film, with many believing that it could just as likely be genetic superman Khan Noonian Singh. And THEN we saw trailer and images of actress Alice Eve, who it seemed could be playing Dr. Elizabeth Dehner, also from the second Star Trek pilot which featured Mitchell, "Where No Man Has Gone Before."
But THEN, came word that she was actually playing Carol Marcus, who audiences met in Star Trek II: The Wrath of Khan 30 years ago, and who turned out to not only be Kirk's lost love but the mother of his son, David. So, inquiring minds want to know, why have Gary Mitchell as a villain yet bring in a tie-in in the form of Carol Marcus that has more of a connection with Khan? Added into the mix is that shot from the Japanese trailer with two hands separated by glass, forming the Vulcan salute (an homage to Spock's death in Wrath of Khan); plus the trailer seems to show nothing telekinetic on Cumberbatch's part, although he does perform some superhuman leaps that would be in line with Khan.
Into this ever-churning recipe of speculation came the announcement this week that Cumberbatch was playing someone named John Harrison, which could have easily be a cover name (though the creatives involved with the production insist that it isn't). JJ Abrams also noted that there are "definitely nods to prior Trek lore in the film."
With all of that in mind, one other thought comes to mind. One of the notions behind the rejiggered timeline as established in the 2009 film is that it would allow Star Trek history to unfold, but in different ways, some massive and some subtle. If we go with the idea that the Enterprise could still encounter many of the same situations that they did the first time around (and that's certainly the premise behind IDW's ongoing comic, which is overseen by the films' co-writer Roberto Orci), in Star Trek Into Darkness couldn't the Enterprise STILL encounter the space vessel S.S. Botany Bay — the ship filled with genetic supermen in suspended animation who fled Earth following the Eugenics Wars. But instead of reawakening Khan as Kirk and company had done so in the original timeline, they instead awaken…oh, say, John Harrison? This would allow the film to tap into Trek lore while taking the idea in an entirely different direction, leaving a sleeping Khan for a potential future adventure.
Does anyone else find that notion intriguing or in the realm of possibility? Would love to hear your thoughts on the whole John Harrison/Gary Mitchell/Khan thing.
: ComicBookMovie.com is protected under the DMCA (Digital Millenium Copyright Act) and...
: ComicBookMovie.com is protected from liability under the DMCA (Digital Millenium Copyright Act) and "Safe Harbor" provisions. This post was submitted by a volunteer contributor who has agreed to our
Code of Conduct
. CBM will disable users who knowingly commit plagiarism, piracy, trademark or copyright infringement. Please
contact us
for expeditious removal of copyrighted/trademarked content. Learn more about our copyright and trademark policies
Related Headlines
Latest Headlines
Comments (33)
From The Web
Top Headlines
JUSTICE LEAGUE Cinematographer Fabian Wagner Would Also Like A Director's Cut Released
The Main Characters Of JUSTICE LEAGUE Ranked From Least To Most Memorable
JUSTICE LEAGUE: Superman FINALLY Joins The Team On These Alex Ross Inspired Posters And Banner
JUSTICE LEAGUE (Finally) Passes The $100 Million Mark At The Domestic Box Office
Visit Our Other Sites!
ComicBookMovie.com Home
CBM Index
Site Map
Terms Of Use
Advertise With Us
Copyright Policies
Trademark Policies
© 2003-2017 Best Little Sites, LLC.
is a registered trademark and has been officially registered with the United States Patent and Trademark Office (USPTO). All logos and images used on this website are registered trademarks of their respective companies. All Rights Reserved. Some of the content presented on our sites has been provided by fans, other unofficial websites or online news sources, and is the sole responsibility of the source from which it was obtained. Best Little Sites is not liable for inaccuracies, errors, or omissions found herein. For removal of copyrighted images, trademarks, or other issues,
Contact Us


text:
Gordon Brown should be worried about today's meeting between David Cameron and President George W Bush, even if it is officially described as a "drop in".
Cameron is being granted a rare visit for an opposition leader
with the US president, the first for a Conservative Party chief
since 2001. Such audiences are usually only reserved for foreign
politicians with a distinguished record, who have a significant
personal connection to an American administration (as was the case
with Iain Duncan Smith), or who are seen as potential
With the Conservatives up to 13 points ahead in the polls, they are now credible contenders to seize the reins of power from Labour, and Washington is taking notice.
The fact that Cameron is being welcomed in the White House speaks volumes about the increasingly frosty state of relations between Downing Street and the Bush Administration. An invitation to a Conservative Party leader would have been unthinkable just a year ago.
The heady days of the Bush-Blair era, with its extraordinarily close-knit partnership, are however long gone, as are American hopes of rekindling it with Brown. The Prime Minister rarely speaks to the American president on the phone, and their first meeting in July was businesslike but underwhelming. While Blair wowed Washington's policy elites on a regular basis, Brown has largely bored them.
The Prime Minister's foreign policy appointments have also raised eyebrows on this side of the Atlantic. His elevation of the fiercely anti-American Mark Malloch Brown as the new Minister for Africa, Asia and the United Nations was a public relations disaster that sent a chill through the Special Relationship.
Malloch Brown has already overshadowed the far less experienced David Miliband, who has hardly set the world alight as Foreign Secretary.
The vast majority of Americans have no idea who Gordon Brown is, but a sizeable chunk could identify French President Nicolas Sarkozy, who was all over American TV screens recently with a glamorous speech to Congress and a genuinely warm tête à tête with President Bush in the Oval Office.
In the space of a few months, Sarkozy has outclassed his British counterpart, and the charismatic French leader is emerging as the most powerful figure in Europe. It is pretty embarrassing when Britain gets edged aside in the affections of the American public by, of all people, the French. And all this when Paris has barely offered anything concrete on the table, while more than 12,000 British troops continue to fight bravely in Iraq and Afghanistan.
It is against this backdrop that David Cameron has been given an important opportunity to make a name for himself on the international stage. It is also a chance to repair some of the damage caused by Shadow Foreign Secretary William Hague's speech to the Royal Institute of International
Affairs which referred recklessly to a "solid but not slavish" alliance, and called for "the effective management of the relationship with the United States of America".
A few months earlier, Cameron chose the fifth anniversary of the 9/11 attacks to call for the need for "humility and patience" in conducting foreign policy, comments that were interpreted in Washington as a direct attack on US leadership of the war on terror. These were not the words of a government in waiting, but insensitive attacks on Britain's closest ally and friend.
There is no bigger setting in international affairs than Washington, and it is important that Cameron projects the qualities of a potential future prime minister, and avoids the kind of knee-jerk anti-Americanism that has become all too common in today's Conservative Party.
There will clearly be disagreements with the US administration, but such disputes should be handled in private discussions and not exploited in order to play to a domestic gallery.
His message in the United States should be unequivocal - that British Conservatives are committed to defending and advancing the Anglo-American Special Relationship, and that the US and Great Britain must remain united in confronting Islamist terrorism and state sponsors of global terror. He must also show leadership over the Iranian nuclear crisis, the biggest threat to international security of our generation. Until now, Cameron has been largely silent on the issue, giving few clues as to how a Conservative administration would deal with the Mullahs of Tehran.
If David Cameron is to walk in the footsteps of Margaret Thatcher and Winston Churchill, there remains a mountain to climb for the Conservative Party leader. He must establish himself as a serious statesman firmly addressing the biggest global issues of the day, from Mahmoud Ahmadinejad's threats to wipe Israel off the map, to the continuing genocide in Darfur. He must also place the alliance with the United States at the heart of British foreign policy, for the world is a far more dangerous place when London and Washington are divided.
This is a high-stakes trip for Mr Cameron, but also an opportunity to demonstrate a truly conservative vision for British foreign policy.
Nile Gardiner is the director of the Margaret Thatcher Center for Freedom.
First appeared in the Yorkshire Post


text:
Spring Back to Vail
April 14-16, 2017
Spring Back to Vail, the annual spring bash celebrating the close of the winter season, returns to Vail for its fourteenth year! World Pond Skimming Championships, free live music, The Bud Light Bags Tournament, sponsor expo village, on mountain luau, giveaways, so much more.
End the season in style with some serious fun under the sun at Spring Back to Vail.


text:
Booker's Bourbon Announces Release of Batch No. 2014-6
Clermont, KY (November 25, 2014) – Booker's® Bourbon announces the release of Batch No. 2014-6, hand-selected by Fred Noe, Beam's 7th Generation Master Distiller, and the "Booker's Bourbon Roundtable" of whiskey writers and experts. Batch No. 2014-6 was selected by secret ballot vote at the Noe family home in Bardstown, Kentucky where the brand's namesake, Booker Noe, tasted each new batch of Booker's Bourbon with friends and family.
In honor of the 25th anniversary of the uncut, unfiltered bourbon, the Booker's Bourbon Roundtable paid homage to Booker's tasting tradition of gathering personal friends around his kitchen table to choose the next batch. This selection marked the first time the Roundtable came together for a live, in-person tasting; they had previously selected all batches through virtual tastings.
"We brought the group to Kentucky to select their last batch of the year in the best way we knew how – by getting together at my dad's house to taste his favorite bourbon," said Fred Noe. "Booker's was founded on my dad's love for great bourbon, so by bringing the Roundtable together at his house, we were able to keep his tasting traditions alive."
The Roundtable panelists – an exclusive group consisting of top whiskey experts, enthusiasts and writers – who hand-selected Batch No. 2014-6 with Fred Noe and Booker's grandson, Freddie Noe, included the following members:
- Chuck Cowdery, Blogger and Author of "Bourbon, Strange: Surprising Stories of American Whiskey"
- John McCarthy, Spirits Writer and Senior Managing Editor of Men's Health Magazine
- Jack Robertiello, Spirits Writer and Judge
- Tony Sachs, Spirits Writer and Huffington Post Blogger
- Fred Minnick, Spirits Writer, Judge, and Author of "Whiskey Women: The Untold Story of How Women Saved Bourbon, Scotch, and Irish Whiskey"
Currently available nationwide, Booker's® Bourbon Batch No. 2014-6, the second to last batch of 2014 and the Roundtable's last selection this year, was chosen based on the following characteristics:
- Proof: 127.7
- Age: 7 years, 2 months and 2 weeks
- Nose: Vanilla with some toasted nuts
- Finish: Long, smooth finish
- Sipping Suggestions: With ice or cut with water
About Booker's® Bourbon
Booker's® Bourbon was inspired by a 200-year-old family tradition and came to life when Booker Noe selected the first bottles of Booker's as holiday gifts for his friends and family. With its instant popularity within Noe's close circle, Booker's Bourbon was soon after bottled and made available on shelves for everyone to enjoy. Booker's Bourbon is one of the only bourbons bottled straight-from-the-barrel, uncut and unfiltered, and bottled at its natural proof, which varies from batch to batch. Crafted in small batches and aged for six to eight years in charred oak barrels, which are stored in the center of the rack house, Booker's Bourbon is hand-selected barrel-by-barrel by Fred Noe to ensure every bottle contains a robust, full-bodied whiskey that has a taste, aroma and proof that matches Booker's whiskey preference.
For more information on Booker's Bourbon, visit: http://smallbatch.com/bookers.
About Beam Suntory Inc.
As the world's third largest premium spirits company, Beam Suntory is Crafting the Spirits that Stir the World. Consumers from all corners of the globe call for the company's brands, including the flagship Jim Beam bourbon and Yamazaki Japanese whisky, as well as world renowned premium brands including Maker's Mark and Knob Creek bourbons, Hakushu and Hibiki Japanese whiskies, Teacher's, Laphroaig, and Bowmore Scotch whiskies, Canadian Club whisky, Courvoisier cognac, Sauza tequila, Pinnacle vodka, and Midori liqueur. The company generates annual worldwide sales exceeding $4 billion excluding excise taxes.
Beam Suntory was created in 2014 by combining the world leader in bourbon and the pioneer in Japanese whisky to form a new company with a deep heritage, passion for quality, innovative spirit and entrepreneurial culture. Headquartered in Deerfield, Illinois, Beam Suntory is a subsidiary of Suntory Holdings Limited of Japan. For more information on Beam Suntory, its brands, and its commitment to social responsibility, please visit www.beamsuntory.com and www.drinksmart.com.


text:
Hempstead boy, 15, goes missing, police say
Nassau police are asking for the public's help in locating a 15-year-old Hempstead boy who went missing Wednesday night.
Milton Valencia was last seen leaving his home around 9 p.m., police said.
He is described as 5-foot-6 and 170 pounds with black hair and brown eyes. Police do not know what he was wearing when he left.
Detectives are asking anyone with information to contact the Missing Persons Squad at 516-573-7347 or 911. All callers will remain anonymous, they said.


text: I write this review after having my roof done 12 years ago by Gemini Home Renovations. The roof was never done right from the very beginning and it leaked after only 3 months. After "trying" to fix the problems I believe the owner felt it was better to take my money and run! and not to stand up and warranty his work. I do not recommend this company to anyone and have told people to drive by my house so they can see what a poor job that was done if they are thinking about using this company.


text:
Importers and companies in soy processing sector can finance their acquisitions using letter of credits opened by Raiffeisen Bank. The maximum amount that can be allocated to the bank is $25 million with 3 year maturity.
The repayment is made depending on the commercial cycle of each business, the bank said in a release.
"Importers or companies in soy processing and of products derived from soy are eligible for the program, as the Romanian market is still at its infancy in this sector", said the first deputy president of Raiffeisen Bank, Marinel Burduja (photo).
The Export Credit Guarantee Program run by US Department of Agriculture is designed to the acquisition of agricultural products (cereals, meat and other food products coming from the United States).
Raiffeisen Bank has 558 retail units and offers phone banking services (Raiffeisen Direct), mobile banking (myBanking), Internet banking (Raiffeisen Online). The bank's customer base includes around 1.97 natural persons, 100,000 SMEs and over 6,800 large and medium companies.
Inregistreaza-te pe Wall-Street sau conecteaza-te prin Facebook pentru a primi periodic articole similare.
In lipsa unui acord scris din partea InternetCorp, puteti prelua maxim 500 de caractere din acest articol daca precizati sursa si daca inserati vizibil linkul articolului Raiffeisen Bank lends US agricultural importers.


text:
Editor's Note: This article was originally written by our friends at OFFGRIDweb.com. Check out their web site for more survival-related tips.
While living through a real disaster would be no walk in the park, practicing those survival skills doesn't have to be a total drag.
In normal circumstances, it can be a lot of fun to gather some friends and head out into the woods to practice fire-starting or shelter-building.
RELATED: How to start a campfire by using an improved hand drill
A crackling campfire, hot meal and some cold beers make the experience all the more enjoyable.Unfortunately, transporting beer to remote locations isn't exactly a simple task.
You can lug around a heavy cooler full of ice, but that's no fun, and it's certainly impractical to transport a full-size beer keg in a wheelbarrow or cart to your off-grid campsite.
Bottles break and cans get crushed, both take up lots of pack space, and neither keeps the liquid inside cold for very long.ManCan is a Denver, Colorado-based start-up that has developed a compact and portable beer keg for use in the outdoors.
The ManCan design retains the advantages of a full-size beer keg — substantial capacity, maximum freshness and easy dispensing — without the tremendous size and weight.
It's also said to be extremely durable, and fits in a refrigerator door so you can chill it before your adventure.The ManCan is powered by standard CO2 canisters and a built-in pressure regulator, and dispenses beer (or any other cold beverage) through the flexible tap hose and nozzle.
It's certainly not what we'd call light, weighing in at about 6 pounds dry, but it's a heck of a lot lighter than the 29.7-pound dry weight of a standard empty beer keg.
When filled to the brim with 128 ounces (one gallon) of beer, it should tip the scales at about 14 pounds, which is relatively manageable for hiking and backpacking. A regular keg would weigh over 150 pounds — good luck carrying that on your back.The 128-ounce ManCan seen here is available for $199 with flex dispensing kit and CO2 cartidges.
You can also order it without the dispenser for $70, or get a smaller 64-ounce ManCan for $40. To learn more about the ManCan line of portable kegs, go to ManCan.beer (yes, that's the real web address).
More from GrindTV
These 5 adventure women are living the dream
An inside look at the oldest trail race in America: The Dipsea Race
More millennials are venturing outdoors than any other age group


text:
Results 1 to 10 of 25
Thread: 11' LSV wake surf ballast set up
Threaded View
11' LSV wake surf ballast set up
Well over Labor Day weekend we finally started to learn how to surf. We went out and it was only Myself, my wife, 3yr old son and a friend of ours. We discovered one thing was we NEED more weight. So what is the best set up you guys have found with the LSV? I have the factory installed Gravity III. So what do i need to start shopping for??
Jeromy11' Mobius LSV
" Yes I am a pirate 200yrs too late"