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Last night I stayed up late to witness the total lunar eclipse, which happens when the moon becomes covered by the Earth's shadow. The moon doesn't go completely dark, but instead takes on a reddish glow, causing some people to call it a "Blood Moon". There will be four consecutive total lunar eclipses happening through September 2015, which scientists call a tetrad. Apparently tetrads are pretty rare occurrences and the next set won't happen until 2032.
I was so glad we had a clear sky to see the eclipse take place. It was fun to bring out my tripod and try to get some shots with my telephoto lens. I'll admit that I had no idea what I was doing, but after experimenting a bit I was able to get a few good shots. Unfortunately, my camera battery died right before the moon was totally covered (just my luck), but that gives me more incentive to stay up late for the next one in October!
Did any of you stay up late to check out the Blood Moon?

subset: commoncrawl


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Call Today!
Autographs, like stamps and coins, are valuable pieces of any collection.
However, there are certain autographs that are valued above all others.
These items, such as those signed by former American presidents, are popular
and sought-after by collectors all over the world. Here is a look at some of
the most famous and most expensive autographs:
Jesse James
Jesse James was one of the most famous outlaws in American history, making
any signature or personal possession of his very valuable. Due to his
outlawry, Jesse James rarely signed anything, but there is one photograph
of Jesse James that includes his autograph, which is valued at $52,000.
Albert Einstein
Though he contributed vast amounts of knowledge to the world of science,
there is a well-known photograph of Albert Einstein sticking his tongue
out to the camera. Einstein himself requested several copies of this iconic
photo, and there are a few that contain his personal signature. Many forgers
have tried to sell this autographed photo, but a real version was eventually
found and sold for $75,000.
Joe DiMaggio and Marilyn Monroe
Joe DiMaggio and Marilyn Monroe ruled different areas of America's
favorite pastimes—DiMaggio was a baseball legend and Monroe was
a Hollywood goddess—but their marriage made them undeniable icons.
They both signed a baseball, which sold for over $191,000, making it the
most expensive baseball memorabilia ever sold at the time.
Abraham Lincoln
Abraham Lincoln is known for many presidential acts, but his Emancipation
Proclamation was one of his greatest. He signed 48 copies of the Proclamation,
and only 26 have survived. One of these autographed documents was sold
in 2010 for $3.7 million.
George Washington
As seen above, presidential autographs are highly valued. In 2012, a signed copy of
Acts of Congress was sold at auction for almost $10 million. This book was owned and signed
by America's first president, George Washington.
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Allied Organisations
All India Organisation of Employers (AIOE)
The All India Organisation of Employers' (AIOE), an allied body of the Federation of Indian Chambers of Commerce and Industry (FICCI), is the oldest and apex national employers organisation of India. It is the platform for Indian industries to raise their voice in formulating labour and social policies to promote business, trade and industry in the country. www.aioe.in
Confederation of Indian Food Trade and Industry (CIFTI)
The Confederation of Indian Food Trade & Industry (CIFTI), is the apex body for the food industry in India . Managed by professionals, CIFTI has in-house R&D facility, a laboratory, strong database with which it provides consultancy services.
FICCI-Confederation of Micro, Small and Medium Enterprises (CMSME)
Established in December 2013, Confederation of Micro, Small and Medium Enterprises (CMSME) is an affiliated body under the umbrella of the Federation of Indian Chambers of Commerce and Industry (FICCI), an apex Chamber of Commerce & Industry of India, with a vision to empower Indian MSMEs and build their competitiveness.
Website: www.ficci-cmsme.in/
FICCI Research and Analysis Centre (FRAC)
FRAC is a Research and Analysis Laboratory of international repute and a "Centre of Excellence" for analysis, product safety, quality control and pre-export inspection and certification. It was established in 1989 under the competent aegis of Federation of Indian Chambers of Commerce and Industry (FICCI) and its allied body Confederation of Indian Food Trade and Industry (CIFTI). It is an autonomous body registered under the Indian Society Act – XXI of 1860 and supported by Ministry of Food Processing Industry, Government of India. FRAC is an ISO: 9001-2008 certified, NABL accredited and BIS approved laboratory.
Website: www.fraclabs.org
FICCI Socio-Economic Development Foundation (FSEDF)
FICCI promotes the spirit of enterprise that will make India a globally competitive and socially responsible economy. With this vision, FICCI set up the Socio Economic Development Foundation (FICCI-SEDF) in 1995 to provide an institutional base to the social sector activities of the corporate sector and to promote Corporate Social Responsibility (CSR) amongst Indian companies. Under the able leadership of Mr P M Sinha, former President, Pepsi Cola International for South Asia, FICCI-SEDF is playing a pivotal role in promoting CSR in India and mobilizing corporate support for critical areas like public health, employment of persons with disabilities, support to disabled soldiers & war widows etc.
Website: www.ficci-sedf.org
Indian Council of Arbitration (ICA)
Indian Council of Arbitration (ICA) was established in 1965 to initiate and popularize arbitration in India. ICA is South Asia's premier arbitral institution and is extremely well respected in the circles of judiciary, executive and legislature within India as well as in the fraternity of Arbitral institutions abroad. ICA not only administers arbitration but has also contributed to the development of law and practice of arbitration both nationally and Internationally.
Website: www.icaindia.co.in
International Chambers of Commerce (ICC India)
In line with its objectives of promoting liberlisation in the country, accelerating flow of foreign investment and lowering tariff barriers to promote international trade, ICC India has been playing a crucial role of interacting with government & business on economic policies. As the process of economic reforms is gaining ground, it is emerging as a rallying point for Indian business in their effort towards globalisation.
Website: www.iccindiaonline.org
Invest India
Invest India is the country's official agency dedicated to investment promotion and facilitation. Set up as a joint venture between FICCI (51% equity), DIPP (35% equity held by the Department of Industrial policy and Promotion, Ministry of Commerce & Industry) and State Governments of India (0.5% each), its mandate is to become the first reference point for the global investment community.
Website: www.investindia.gov.in
Associate Partners
FICCI Ladies Organisation
FICCI Ladies Organisation (FLO) is a national body with the prime objective of women empowerment through the promotion of entrepreneurship and managerial excellence.
Established in 1983, FLO is a division of the Federation of Indian Chambers of Commerce and Industry (FICCI), which is the apex body of Industry and Chambers of Commerce in India.
Over the last 29 years of FLOs existence it has grown as an organization and today it is one of the most prestigious pan-India business organizations with 10 chapters and nearly 3200 members across India, committed to working towards women empowerment through business women development and capacity building initiatives besides other programmes.
Website: www.ficciflo.com
FICCI Aditya Birla Centre of excellence
FICCI ADITYA BIRLA CSR CENTRE FOR EXCELLENCE has evolved in consonance with Mahatma Gandhi's dream: ethics-based business practices leading to improvement in the quality of life for the common people. The centre envisions- To incubate, nurture and accelerate a paradigm of sustainable and inclusive CSR in India and across the globe, thereby raising the Human Development Index through poverty alleviation.
The Centre for Excellence is a joint endeavor of Federation of Indian Chambers of Commerce & Industry (FICCI), a rallying point for free enterprise in India since 1927 and the Aditya Birla Group - a prominent business group with a mission to deliver superior value to customers, shareholders, employees and society at large.
Website: www.csrcfe.org


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Simply because:
- People can simply get around the filter by saying "Sh1t" or "Sh!t" instead of "Shit"
- You could type a paragraph, and have your whole message deleted because you didn't know something ridiculous such as "Guide" was "Profane"
- To sign up for the website, you need to be 17 or older. Implying most have experience with profanity and use it regularly to add emphasis on what they are saying.
When looked upon logically, this profanity filter makes no sense. The only reason for it would be to make the site look more professional, although this site can never look professional with all the trolls and such.
The ONLY thing the word filter does to this site, is add stress to the users.
And at the end of the day, isn't the goal to make the site more user friendly?


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Calculate your tip and split your restaurant bill among friends with ease
Micromax Bolt A69 smartphone was launched in May 2014. The phone comes with a 4.50-inch touchscreen display with a resolution of 480 pixels by 854 pixels.
The Micromax Bolt A69 is powered by 1GHz dual-core Broadcom BCM21663 processor and it comes with 512MB of RAM. The phone packs 4GB of internal storage that can be expanded up to 32GB via a microSD card. As far as the cameras are concerned, the Micromax Bolt A69 packs a 5-megapixel primary camera on the rear and a 0.3-megapixel front shooter for selfies.
The Micromax Bolt A69 runs Android 4.2 and is powered by a 1800mAh removable battery.
The Micromax Bolt A69 is a dual SIM (GSM and GSM) smartphone that accepts Regular and Regular. Connectivity options include Wi-Fi, Bluetooth, FM and 3G. Sensors on the phone include Proximity sensor and Accelerometer.
How to download Touch Tip form Micromax Bolt A69?
- Check the Android version to verify compatibility of Touch Tip with Micromax Bolt A69.
Find Android version: go to "Settings" - "About the phone" - "Android version". Make sure Touch Tip is compatible with Micromax Bolt A69.
- Click the download button to download Touch Tip in Micromax Bolt A69.
- Once the download and installation are complete, find Touch Tip in your home screen and tap the icon to open it.
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WordReader read MS Word filesDownload
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About Penélope Tidor
Penélope Tidor is a published author. A published credit of Penélope Tidor is Cuentos De Cura Sanita (Cuentos Para Contar).To edit or update the above biography on Penélope Tidor, please Log In or Register.
Link to this page: https://www.jacketflap.com/penlope-tidor/164661
Published Works by Penélope Tidor
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Oasis Auto Mildura is a trusted mechanic, with factory trained technicians who have over 150 years combined experience.
Our workshop has access to the latest technology, and has all the equipment to service and repair your vehicle.
Oasis Auto Service Mildura, your local Bosch Service Dealer, is the specialist in maintaining and repairing all makes and models. Most vehicles today incorporate unprecedented levels of sophisticated components making a reliable and efficient service invaluable.
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text: Like my two favorite people these days. Lufff these guys so much....what am I ever going to do without them??? We have the most fun together, Seattle would be so bland without them. Luckily Stefan is moving back to London shortly after I do, but nothing will be the same without the 3 of us :'(


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Leigh MatthewsPrint Page
Commemorates Leigh Matthews, Australian Rules footballer who was one of the greatest legends at Hawthorn Football Club and many would argue that he was the finest footballer ever to take the field. As a rover/forward Leigh Matthews had a wonderful football brain and could always read the play.
He was a solid player who could turn a game around in a matter of minutes. Matthews made great use of the hip and shoulder especialy when the oppersition came between him and the ball, but he also copped plenty in his time. He polled over 200 votes in his time with Hawthorn but unfortunately never won a Brownlow Medal. Matthews last game was in the 1985 Grand Final against Essendon.
After 17 seasons the tough and explosive little man was shouldered off the MCG by his team-mates, an emotional but fitting send off to a brilliant career. Leigh Matthews was inducted into the AFL`s 1996 Hall of Fame
|Brunton Avenue, Melbourne Cricket Ground, Melbourne, 3000
|GPS Coordinates:
|Lat: -37.820646
Long: 144.982155
Note: GPS Coordinates are approximate.
|Monument Type:
|Monument Theme:
|Monument Designer:
|Louis Laumen
Leigh Matthews 1952. Combining a rare blend of skill, strength and aggression, `Lethal` Leigh Matthews was a champion rover/forward for Hawthorn who kicked 915 goals in 322 games and played in four premiership teams. He represented Victoria 14 times. He coached Collingwood to the 190 premiership and Brisbane for 1999 winning successive premierships in 2001, 2002 and 2003.


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Xbox One
Ryse developers chose 30fps over 60
- Topic Archived
You're browsing the GameFAQs Message Boards as a guest. Sign Up for free (or Log In if you already have an account) to be able to post messages, change how messages are displayed, and view media in posts.
"Developers always have to choose whether they go for 60 or 30fps, depending on the type of game and complexity of the project. With Ryse, we wanted to go for a very emotional experience with complex and dramatic lighting, high fidelity environments, and rich characters and character animations. So 30fps was our choice, and we believe that most developers will go for richer worlds at 30 frames per second rather than 60fps – which would call for compromises, as 60fps demands twice the amount of compute rendering speed. 30fps is a standard that is above, for example, what most cinemas use for showing films. Early demos with higher frame-rate experiences have shown that gamers and viewers have a mixed opinion about its perceived quality – for example, how 48fps cinema experiences were received. So it's both a production design choice as well as user research."
60fps would've been a nice upgrade for next gen, so too bad that couldn't happen. Even with a 900p resolution I guess they still had to compromise with the framerate too. Too many details on screen to run at 60 frames. I just hope it's a solid 30 with no slowdown. I like playing action games at 60fps.
and we believe that most developers will go for richer worlds at 30 frames per second rather than 60fps
This is a problem. It's not something gamers should accept. Ever. Gamers should speak up and tell developers that frame rate is more important than shiny particle effects, overindulgent textures, and horrible, awful, post processing effects.
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A_Nonny_Moose 4 years ago#3
Well yeah, of course they chose it. Do people think they just made the whole game without considering the framerate and then thought "Hey, let's check out how the game runs. 30fps? That'll do I guess."?
BigPapi829 4 years ago#4
Dev0311 posted...
Killzone is going for 30fps for sp does that mean it can't go 60fps no it doesn't, because the Devs know what is best for their game so if the makers say their will be a better experience at 30 vs 60 I would believe them
MasteroftheArts 4 years ago#5
Dev0311 posted...
While I'll probably end up buying Ryse, I think the example of comparing Peter Jackson's desire to shoot the Hobbit in 48 fps is not analogous to an action video game like Ryse for two reasons.
1) The primary criticism of the 48 fps shoot was that it eliminated the suspension of disbelief by making the characters look like they were in a soap. It literally looked like the characters were walking around a set. Except in rare instances, suspension of disbelief isn't a factor when playing games. So the argument that 30 fps is fine simply because it's higher than the industry standard 24 fps for cinema just doesn't work. The dreamy look that 24 fps gives is not desirable in gaming.
2) The reason why the movie was shot at that framerate was to reduce motion blur and flicker during fast-paced action scenes. In Ryse, unless they're going for a more cinematic feel, this argument wouldn't seem to bolster their decision to go 30fps, but instead would weaken it.
Just admit that the game can't run properly on 1080p at 60fps. The new Legend of Zelda WindWaker HD runs at 1080p 60fps, but no one is contending that it is more graphically appealing than Killzone or Dead Rising 3. That's because this entire argument over definition and framerate is a red herring when debating a game's graphical capability.
"I refuse to prove that I exist" says God. "For proof denies faith, and without faith I am nothing..."
BrownGotti 4 years ago#6
I would prefer the particle effects and extra textures than 30 more fps. My 1080P bluejays seem just fine.
BrownGotti posted...
I would prefer the particle effects and extra textures than 30 more fps. My 1080P bluejays seem just fine.
Frame rate in movies is a totally different beast.
Other than just the aesthetic, frame rate in video games is tied to responsiveness.
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The_Darkwalker 4 years ago#8
Foxx3k posted...
and we believe that most developers will go for richer worlds at 30 frames per second rather than 60fps
Just because a game runs at 60 fps doesn't mean it automatically and without exception will be more graphically impressive than every 30 fps game it is compared to. Will it have the appearance of running faster and more smoothly? Sure. But what if that 60 fps game has sacrificed more particle effects, richer textures and better lighting just for the sake of being able to make the claim that it runs faster?
You might not care. That a game needs to run at 60 fps at any cost might be one of the main criteria you personally look for, but for many of us that is less important than sum of all its other aspects. Ideally, all next gen games would run at 60 fps at 1080p with everything cranked up to 10. Clearly this is not going to be the standard going forward. 60 fps at 720p, or 30 fps at 1080p seem to be the two flavors that will be on offer once the new systems drop. Saying one is worse than the other simply because it runs at a slower frame rate is certainly your prerogative, but it it is definitely not the community or industry consensus at the present time.
Evil always wins because Good is dumb.
BrownGotti posted...
I would prefer the particle effects and extra textures than 30 more fps. My 1080P bluejays seem just fine.
Pretty bird!
There's the deltoids of compassion; There's the abs of being kind.
It's not enough to bash in heads, you've got to bash in minds...
Ryse developers would rather improve their artwork than give players a better playing experience.
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Adkins takes loss in his stride
Southampton boss Nigel Adkins refused to look for excuses after they were beaten 1-0 by basement club Doncaster.
Last Updated: 03/12/11 7:02pm
Southampton boss Nigel Adkins refused to look for excuses as his table-toppers were beaten 1-0 by basement club Doncaster.
The Championship leaders were without top scorer Rickie Lambert and lacked their customary cutting edge on this occasion.
Billy Sharp notched his seventh goal of the campaign on the hour mark to give the Yorkshire club a morale-boosting win.
Adkins was full of humility in defeat and would not except their loss was down to Lambert's injury.
"Everyone has injuries from time to time and you have to cope with them," said Adkins.
"You can't afford to rely on one player but we are not going to hide from the result.
"The top team is expected to beat the bottom and it didn't happen - but that's football.
"We prepared properly for the game and showed Doncaster the utmost respect so it wasn't a case of being complacent.
"But we gave a goal away through a lapse of concentration and it gave them something to hang on to, which they did.
"In fairness to Doncaster they worked hard and had a spirit about them but we need to improve our away form if we want to stay at the top."
Rovers boss Dean Saunders, whose side are no longer 24th in the table, said: "That's been coming for some time and I thought we deserved it.
"We had a lot of players missing through injury but those who did play today did brilliant and hopefully we can climb the table now.
"We've been giving Sunday League goals away in some games but that didn't happen today and the players are learning all the time.
"There were some excellent performances all round today and we are starting to get used to each other and gel together.
"Very few people will have given us a chance of winning that game but I have confidence in the players that they can beat any team in the division."


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LP Gear stylus for BSR XL-1200 XL 1200 XL1200 turntableSBSRXL1200
LP Gear stylus for BSR XL-1200 XL 1200 XL1200 turntableCode: SBSRXL1200
- Product Info
The BSR XL-1200 XL 1200 XL1200 turntable was fitted with an integrated cartridge and a BSR DS-ST16 DSST16 stylus. A photo of the stylus replacement is supplied above. The stylus features a highly polished conical diamond for long playing life, reduced record wear and good rendition of voice and music. The color of the stylus varies. Please verify and use this as a guide only since the cartridge and stylus may have been changed through the years.
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Cube has new music coming.
For fans of veteran Ice Cube, yesterday was definitely a good day.
Following the release of his new single "Only One Me," which features defiant not-dead-yet lyrics, Cube confirmed on Twitter that a new album from the rap mogul is coming.
It's coming https://t.co/k6cvg4cCo9— Ice Cube (@icecube) June 3, 2017
More recognized for his film and television endeavors as of late, fans on social media could not contain their excitement at the prospect of Ice Cube gifting us with a new collection of music.
@meeks_slays finally 😩 I'm sick of all this trap music coming out— Michael Johnson (@Johnsonn_M) June 3, 2017
Is it really?😍😍😍😍— Juanita🔴 (@juanita_dior) June 4, 2017
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It will be interesting to see if all of his new material will carry the same level of hardness, but only time will tell. There are no official details concerning a release date.


text:
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Educational Qualification - All Interested Candidates should have completed MBBS Degree or its equivalent qualification from a recognized Board/University. For Post Wise Qualification Go To Detailed Advertisement.
Selection Procedure - Interview
How To Apply - All Eligible and Interested candidates are required to visit official website http://www.indiapost.gov.in. After Filling The application form, candidate must send hard copy of application along with relevant testimonials (Mentioned In Detailed Advertisement) to the following Address before or on 16-11-2014.
Address -Assistant Director Postal Services (Staff) , Postmaster General ,Bareilly Region, Bareilly – 243001 .
Important Dates To Remember- Last Date for Receiving of Application Form Is: 16-11-2014 .


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Brook Bungalow is a modern property set on ½ acre of land in the coastal village of Holme-next-the-Sea which is close to Hunstanton in Norfolk.
You can find this advert on our website www.theholidaycottages.co.uk by clicking on the details below:
Brook Bungalow Holme-next-the-Sea, Hunstanton, Norfolk
The bungalow provides self catering accommodation for up to 8 people and it is an ideal location for exploring the sandy beaches and the Nature Reserve which is to the rear of the property.
The front garden is laid down to lawn and shrubs, surrounded by hedges and trees which protect a sunny patio area.
The elegant resort of Hunstanton has a beautiful coastline and plenty of attractions to keep the whole family occupied including the Sea Life Sanctuary, Princess Theatre, Hunstanton Cliffs, Hunstanton Wash Monster and Snettisham RSPB Reserve.
The Holiday Cottages is an online user friendly directory for self catering accommodation in the UK and Ireland. To keep up to date with the properties on our website join us our social media websites below:
With over a decade of experience in promoting self-catering property, we at The Holiday Cottages try our best to ensure you our customers receive a personal and friendly service and an effective way to create business for your accommodation.
All bookings and enquiries go straight through to you, so click on our advertising link below and join us today:


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What's on Your Mind
- Artist: Sareal
- Genre: Soul/R & B
- Release Date: 5/2/2006
Sareal a 27-year-old artist born as Sherica Donelson started her career when she was younger, singing in the church. She was born on March 16, 1978 here in Memphis, Tennessee. She has enjoyed music for many years by watching and listening to her Granddad. As she was growing up she felt through music, she will be able to express herself and open up to people because she was so shy. She experimented with instruments, not having any luck until she found out that she could sing. She tested her career by joining a group called Neutral in 1998. This group consisted of 2 guys and 2 girls. The group had to split up because of business reasons and Sareal had to reroute her career. Now, as a 27 year old woman she has felt the rhythm blues of R & B again and decided that this was going to her career choice. She auditioned and signed with RIPP Entertainment on March of 2005 and is due to release an album on April 25, 2006 entitled' "What's On Your Mind." popular hit songs from the album include: Just Another Feeling, You Said and with her number one hit, 'What's On Your Mind.' You haven't heard anything yet til you've heard the new artist signed to RIPP Entertainment. RIPP Entertainment will be releasing 5 year old Lil Chris's rap album on June 13 entitled, 'Kindergarten Kid.' Purchase it when it becomes available!
|What's on Your Mind
|Soul/R & B
|CD Baby
|Release Date:
|Product Type:
|Item #:
|This product is a special order


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On October 30, 2015, an objection to the motion for authority to take discovery was filed in the bankruptcy case of Energy Future Holdings Corp. and its affiliates.
The filing was assigned docket number 6805 and is described on the court's official docket as follows:
Objection (Debtors' Opposition to EFH Committee's Motion In Limine to Exclude Evidence of Consultation with Counsel Offered to Support Reasonableness of Settlement) (Redacted) (related document(s)[6741]) Filed by Energy Future Holdings Corp. (Attachments: # (1) Exhibit A) (Madron, Jason)
Energy Future Holdings Corp. filed for bankruptcy protection, or had an involuntary bankruptcy petition filed against it, on April 29, 2014. The bankruptcy case is pending before the United States Bankruptcy Court for the District of Delaware. The case number for the lead bankruptcy case is 14-10979. The bankruptcy case is currently assigned to United States Bankruptcy Judge Christopher Sontchi. The law firm of Kirkland & Ellis LLP is acting as lead bankruptcy counsel to Energy Future Holdings Corp. in the bankruptcy case.


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CalorieSmart Calorie Counter, Nutrition Tracker, Diet and Fitness Tracker
By Coheso, Inc.
This app is only available on the App Store for iOS devices.
Easy to use, fast calorie tracker. We make it easy to track and monitor what you eat.
Track Calories, Carbs and other nutrition information. With details for 100,000 foods, 300 restaurants, and 500 specific brands, CalorieSmart helps you stay connected to nutrition values anytime, anywhere.
* Nutrition info for 100,000 foods, 300 popular fast food and casual dining restaurants and 500 specific food brands
* Adjustable serving sizes for ounces, grams, cups, and items
* Supports US and SI (metric) units
* Sync to our cloud servers to backup data and to use multiple devices to access your logbook.
* Track your body weight
* Use the calorie needs calculator to estimate how many calories you should be consuming for your weight goals
* Record daily calorie and exercise goals
* Build a "favorites" list of foods and exercises for quick entry
* Create pre-set entry categories like "100 calorie snack" or "morning coffee with creamer"
* Utilize exercise calorie per minute values specific to your weight, time spent, and type of exercise done
* Enter direct calorie values displayed from cardio machine workouts
* Create customized exercise routine entries, such as 200 calorie yoga class.
* See daily totals for calories eaten and burned
* Email your log information that can be opened by any spreadsheet program.
* Great for weight loss goals that fit with all types of diets
* Helpful for those with special nutrition concerns such as diabetics, pregnant women, and athletes
* Incorporates a regularly updated food and exercise database every time you update this App
Make your weight loss and nutrition goals a reality.
Since 2003, Coheso, based in Pleasanton, California has been making health management tools. Healthy eating tips and other useful information are at http://www.coheso.com. A complete restaurant list is available at http://www.coheso.com/nutridata/.
What's New in Version 7.0
Fix IOS8 related issues
iPhone Screenshots
Customer Reviews
Cats meow
Love it. Pre-diabetic, hyper-lipidemia and hypertension. This app does Everything I need except for quick input. Maybe someday functional voice recognition will solve that problem. Great app.
However, synchronizing with the lousy Web interface doesn't work very well. Which is ok because the Web site STINKS!
Great tracker
Great app.. Allows for easy entry for homemade foods. Easy to recall favorite foods. Really helps with macros/ micro taking
- $1.99
- Category: Health & Fitness
- Updated: Oct 06, 2014
- Version: 7.0
- Size: 34.2 MB
- Language: English
- Seller: Coheso, Inc
- © Coheso, Inc.
Compatibility: Requires iOS 8.0 or later. Compatible with iPhone, iPad, and iPod touch.


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AMU Answer Key
Candidates who are going to appear in B.SC/B.Tech/MBBS Entrance Exam may check their AMU Answer Key with the help of this page. Here we have summarized all the details regarding the AMU Entrance Exam Answer Key. The Aligarh Muslim University conducts the AMU Entrance Exam for those candidates who want to take admission in various UG/.PG Courses and after the commencement of Entrance Exam the university releases the AMU Answer Sheet. Candidates may get their (A/B/C/D) set wise AMU Answer sheet with the help of the information mentioned below.
To get the Aligarh Muslim University Answer Key candidates can visit the official website of the university i.e. amu.ac.in, furthermore candidates can also follow the below stated steps that will redirect the aspirant to the AMU Answer Key 2017.
Highlights of this page:
Candidates who are going to appear in the examination are advised to check this page regularly after appearing in the examination as after the commencement of the examination direct links regarding the AMU Entrance Exam Answer Key will be available here on this page. Usually the answer keys are release after two or three days of examination. And hoping the same this year also it will be release after the same duration. All the aspirants who have appeared in the entrance examination will be able to download the answer key from this page and will be able to calculate an approx result before the declaration of results.
How candidates can avail AMU Answer Key?
Aspirants who want to download Aligarh Muslim University Answer Key they can obtain it by following some simple steps which are well mentioned below…
- At initial start with visiting the official web portal i.e. www.amu.ac.in
- Move the cursor towards the 'Admissions & Exams' section that is visible in menu bar on the home page.
- From the new page appeared select 'General Admissions' link.
- Afterwards select a suitable link for answer key.
- By selecting above link a new screen will come out along with the answer key for the examination conducted.
- Thereafter check out your answers and download the answer key and take a print out of it for using it further and comparing your answers.
- Candidates may also prepare Discrepancy Report if they find any error in Answer Key by hitting report link.
- Students have to enter Name of candidate, Roll No. and other information to prepare Discrepancy Report.
Read Also:-How To Download Answer Key?
AMU Answer Key
Reason behind conducting the exam:
AMU Medical / PG Entrance Exam is organized by Aligarh Muslim University to provide admission to talented candidates in various UG/PG/Medical courses like B.SC/ B.Tech /MBBS. There is a wide range of candidates who appears in this examination this year also the university is going to conduct the entrance examination on mentioned dates. After the co0mmencement of examination university will release the answer key which will help the candidates in calculating an approx score for their examination.
Candidates who are going to appear in AMU entrance exam 2017 to get admission in various UG/PG/Medical courses in different disciplines they can easily match their correct/in-correct answers through this Answer Key.
Check Here: Aligarh Muslim University Results
Important Dates:
|Exam Date
|Answer Key
(link will be updated here)
|B.Sc./ B.Com./ B.A. (Hons.)
The direct link for Answer Key
will be available here after
approx 3 days of examination.
|B.Tech./ B.Arch.
|MBA/ MBA (I.B.)/ P.G. Dip. in
Islamic Banking & Finance
|Diploma in Engineering
|Senior Secondary School Certificate
(Science Stream)
|Senior Secondary School Certificate
(Humanities & Commerce Stream)
Want to Know? How to Get Admission in Engineering Colleges?
Candidates who are looking for AMU Answer Key 2017 they can direct download it by pressing below given Official Link. Appliers may also follow us on facebook and Google plus to attain latest updates in this concern direct to your mailbox.
Something That You Should Put an Eye On
|AMU Courses Offered
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|How Do Toppers Study?
|Get a Free College Education
|List of UGC Approved University
|College is AICTE Approved?


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We have box spoilers for the JackedPack June 2015 health & fitness subscription box. Every month, JackedPack delivers 5-10 samples, customized to meet your fitness goals and flavor preferences.
Here's a sneak peek at some of the supplement samples that could be in your June JackedPack box:
- BPI ISO HD – Chocolate Brownie
- BPI 1.M.R Vortex – Snow Cone
- BPI Best BCAA – Grape
- Nutrabio 100% Whey Protein Isolate – Dutch Chocolate
- Nutrabio PRE Extreme – Watermelon
- Nutrabio BCAA 5000 – Grape
- ProSupps Dr. Jekyll – Orange Burst
- MuscleMeds Carnivor Brownie – Chocolate Fudge
- Cellucor C4 – Blue Razz
- TapouT Turbo Blend Protein Powder – Chocolate
- ProMera Sports Amino-Tren – Mandarin
Subscribe by June 23, 2015 to receive the June JackedPack box!
Which June JackedPack spoiler are you excited to try?
About JackedPack
Get supplements and the best products in sports nutrition delivered monthly with a JackedPack monthly subscription box.
- Price: Starting at $15/month
- Items per Box: 6-8
- Ships to: Cont. US
- Read Subscriber Reviews


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Medium Rosewood Pocket Watch Stand with Brass Fittings by Hillwood RRP £39.95
Sold for:
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- Sold Date:
- Source: eBay UK
Medium Rosewood Pocket Watch StandThis standard sized pocket watch stand is made from solid Rosewood and has 12 coats of lacquer bringing to a high gloss finish. It is further enhanced with a deep rich rosewood stain and brass fittings.It has a central brass hook for holding a pocket watch and a central bowl to place the watch chain if required. A great display piece for any pocket watch. This is a second quality stand which is why it is being sold off. It has some very minor ripples in the lacquer which occured during manufacture.. These are not that noticeable unless you are up close and dont show up at all in the picture above as they are so small. The stand is otherwise in very good condition and will be a great buy for the lucky winner. The stand is 14cm in height. The width between the posts where the watch hangs is 5.5cm so will take any standard sized pocket watch. The normal price of this item is £39.95 so is bound to be a bargain for the lucky bidder. Postage and Packaging Details Combined Postage - UK Mainland Where possible I will alwayscombine postage. If you buy more than one item, please don't make payment straight away. Wait for a combined postage invoice. Small items are delivered from stock with Royal Mail 1st Class standard or recorded post as specified ... read more


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Gelati CollectionReviews : Average (117 reviews)
Duffle Bag
Regular Price: $49.95
Special Price $44.96
Gelati Drink Bottle
Regular Price: $24.95
Special Price $22.46
Swim Bag
Regular Price: $29.95
Special Price $26.96
Large Lunchbox
Regular Price: $39.95
Special Price $35.96
Book Bag
Regular Price: $29.95
Special Price $26.96
Lunch Bag
Regular Price: $39.95
Special Price $35.96
Large Pencil Case
Regular Price: $24.95
Special Price $22.00
Mini Backpack
Regular Price: $39.95
Special Price $35.96
Sun Hat
Regular Price: $29.95
Special Price $26.96
Gelati Collection Reviews
Perfect item for my daughter, bag remains cold for periods of timeReviewed on 30 May 2016
Always happy with my products I order from Stuck On You!Reviewed on 23 May 2016
Was what was expectedReviewed on 20 May 2016
Excellent as always!Reviewed on 20 May 2016
We love to hear from our loyal customers! Thank you so much for your excellent review and ratings!
Our Drink Bottles are perfect for kids and adults alike!
They are made of a super strong, food grade stainless steel and our lids are BPA free.
I'm sure your will love it's Gelati Desgin!
Kind Regards,
Stuck On You Customer Service
Really good quality. Smaller than i thought though but its still great.Reviewed on 20 May 2016
Perfect gift!Reviewed on 16 May 2016
Welcome to our company! We are so thrilled to know that as a first time customer, you have found our website easy to navigate, customise and order.
Our Mini Backpacks are a great gift! So easy for a toddler to carry around on their own. Toddlers love to take ownership! I'm sure they will especially love to have a bag personalised to them.
Thank you for submitting your review. We hope you shop with us again soon!
Kind Regards,
Stuck On You Customer Service
ExcellentReviewed on 11 May 2016
Thank you for your excellent ratings!
Our Personalised Sports Swim Bags are great. The drawstring makes it so easy to carry for all ages! It also helps to keep your items secure!
We look forward to hearing from you again soon!
Kind Regards,
Stuck On You Customer Service
Expensive for what you getReviewed on 02 May 2016
Thank you for taking the time to provide feedback and review we appreciate it!
I am sorry to see you were not happy with the price of the Mini Backpack, They are a great product and of sound quality, I know the Mini Back pack will be well loved and used.
Kind Regards,
Stuck On You Customer Service
So cute !Reviewed on 30 Apr 2016
Our Mini Backpacks are so cute! Perfect for the little ones to feel independent and carry their own bag.
We are so pleased to hear that you are very happy with your purchase.
Thank you for your feedback and ratings, we really appreciate it.
Kind Regards,
Stuck On You Customer Service
But it is small.... Difficult to fit change of clothes, bottle, sleeping etc in for daycareReviewed on 28 Apr 2016
Thank you for your honest review and comments.
Our Mini Backpacks are perfect for coffee outings with mum or dad, just big enough to fit in some paper and pencils and their favourite toy. Perfect size for them to feel independent carrying their own personalised bag.
All our sizing information can be found each product page on our website.
We hope you have great use from your Backpack and Split Pack!
Kind Regards,
Stuck On You Customer Service


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The American Dream
The AMERICAN DREAM is a 30 minute animated film that shows you how you've been scammed by the most basic elements of our government systemContinue reading →
The AMERICAN DREAM is a 30 minute animated film that shows you how you've been scammed by the most basic elements of our government systemContinue reading →
Before the Music Dies (B4MD) is a 2006 documentary film that criticizes the American music industry and the increasing commercialization of the art of music over the past thirty years.Continue reading →
If you are a fan of Southern Rock then you are going to like this band, hands down. They have that bluesy kind of guitar driven sound that is so addictive and they do it well.Continue reading →
It kinda sounds like Eminem but with a much heavier dose of humor. Maybe if you crossed Eminem with Weird Al the product might resemble Jay B.Continue reading →
I think that this song captures some of the anger and frustration being felt in the US at the moment.Continue reading →
This video might just as well be called a short film due to the large amount of time they spend building the ideas of the song before they ever start to play the music…Continue reading →
SEX SLAVES are a living, breathing war machine. They have independently performed over 1,000 live shows in 13 countries, and counting…all without a major label's tour support dollars, or corporate sponsorshipContinue reading →
In conjunction with the 25th Anniversary of the Super Mario Brothers video game, emcee Never Yet Contested and Tru Statement Entertainment present the "Retro" online video experienceContinue reading →
The story of Star Fucking Hipsters begins in 2004, when world renowned ska-punks Leftöver Crack were about to head out on their annual European tour…Continue reading →
MeTalkPretty is all about defying odds. Overcoming language barriers and gender stereotypes, this hip, young, and fashionable New York City Alt-Rock group with a female immigrant lead singer has found success through an intense DIY work ethic and emphasis on live performance.Continue reading →


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This post by Dorie Clark first appeared in The Guardian.
Is 2014 going to be the year you get a promotion, or land that job you've been dreaming about? If you really want to reinvent your career and make your professional life more fulfilling, it's time to take decisive action.
But how can you can set yourself apart from your peers and ensure you're not stuck waiting around for callbacks? Have a go at these five personal branding tips.
Sharpen your narrative
What do you say when someone asks: "what have you been up to lately?" Don't waste the opportunity, as so many do, with a ridiculous platitude ("not much" or "same old, same old"). It's important to make sure you always have something to contribute to the conversation, which shows you're staying current and interested in new challenges. Talk about a charity you've been volunteering for, or the most exciting project you're doing at work.
Rekindle old ties
When it comes to rebranding yourself, sometimes the people closest to you are the toughest sell. They know you as X, so how is it possible that you could be Y? One professional reinvention secret that you might want to tap in 2014 is rekindling "dormant ties" – a phenomenon Wharton professor Adam Grant has written about.
Dormant ties are people you used to know, but haven't been in touch with for quite a while. You still have a bond with them from days past, but since it's been five or 10 years, they expect that you'll have changed and grown. In the interim, they've picked up new contacts and networks, and may be willing to help you as you pursue even greater opportunities (and, hopefully, you can return the favour).
Seize on an emerging trend
When you're first building a name for yourself, it's hard to be a generalist. If you want to become known as an expert in sports or politics, there's infinite competition. But if you pick an emerging trend, you often have a clear path forward.
As technology thought leader Robert Scoble told me in a recent interview: "If you pick a single niche that isn't well covered – like Google Glass – and you have an authoritative blog, if Google Glass takes off, all of a sudden you're getting invited to press conferences and other events about wearable [technology]. It's a lot easier to get known as a person who covers a niche." What's the emerging trend you can explore?
Learn one new skill
Of course, we'd all like to learn Mandarin, travel the world, and become master golf, tennis and cricket players. If we have jobs and families, we can't do all those things in 2014, but that doesn't mean you can't pick one to focus on. Choose one specific new skill and make a commitment to master it this year. At the start of 2013, I had never conducted a webinar – by the end of the year, I had run nearly 20. Pick your focus area, and you can do the same.
Start creating content
You're always in a stronger position to negotiate terms and conditions when someone comes to you, rather than when you go begging at their door. The best way to ensure they do is "inbound marketing" or "content marketing", ie the practice of creating content that showcases your expertise and is helpful to others.
There are no excuses anymore; starting a blog is free thanks to sites like WordPress. Don't like to write? Create a video podcast using your smartphone, or simply monologue into the voice memo function of your phone (as social media guru Gary Vaynerchuk does) and pay someone to transcribe it.
The economy is picking up, and the internet puts more tools at our disposal than ever to meet new people, connect with past colleagues, learn skills for free, and share our expertise. It's time to make the most of it in 2014 by building your personal brand and attracting the right kind of opportunities.
Dorie Clark is a marketing strategist who teaches at Duke University's Fuqua School of Business. Find out more about her book, Reinventing You (Harvard Business Review Press) and follow her on Twitter @dorieclark


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Kaabil & Raees 21st Day Collection: Kaabil Vs Raees successfully running third week and 1st week of release both showed their power at the box office. Even both the films got received immense response from audiences and had good word of mouth across India, overseas. As both were released on the same day that clash between movies were continuing from day one to till now.
Check: Kaabil & Raaes 20th Day Collection Details
Kaabil is directed by great director Sanjay Gupta. Creates huge response on the opening week. And made a business in the first week of Rs.82.18 Cr, Also combines weekend collection as Rs.67.46 Cr and weekdays as Rs.14.72 Cr.
Again on the 2nd week, Kaabil stood great and recorded the business and crossed Raees movie. And reported the amount as Rs.17.09 Cr, which combines weekend as Rs.11.71 Cr and weekdays as Rs.5.38 Cr.
3rd Week, Kaabil has collected as Rs.2.65 Cr, on Friday as Rs.0.55 Cr, Saturday as Rs.0.90 Cr, Sunday minted Rs.1.20 Cr.
Kaabil 21 Day Collections:
Completion of 3rd week, overall income of Indian or domestic as Rs.101.92 Cr. So, Again it enters into weekdays, usually it is facing less occupancy at screens and obviously drop can be expected in collections. Minted amount on Monday as Rs.0.42 Cr. On the occasion of Valentine's Day Thuesday movie was collected Rs.0.54 Cr and became total collections till today that is 21 days of release as Rs.102.88 Cr.
Raees was directed by Rahul Dholakia and made earnings of opening week as Rs.118.36 Cr, Along weekend of Rs.93.24 Cr, during weekdays as Rs.25.12 Cr. 2nd week, it earned Rs.16.40 Cr, Total weekdays + Weekend as Rs.11.55 + 4.85 Cr.
Raees 21st Day Collection:
Raees enters into the 3rd week, and made a business of total 1.65 Cr, which added as follows on Friday as Rs.0.30 Cr and on Saturday as Rs.0.55 Cr, Sunday as Rs.0.80 Cr and witnessed total 19 days business as Rs.136.41 Cr. Weekdays impact is there as usual less occupancy in theaters and Monday somehow it earns Rs.0.24 Cr. As we all knew occasion of Valentine's Day on Tuesday, There is a growth in increase and made as Rs.0.31 Cr, Total collections after 21 days as Rs.136.96 Cr.
Please stay tuned for updates @boxofficereporter.com


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"Whiteman: The Legacy of Freedom" Sculptures at Katy Park
New sculptures sit on the corner of 24th and Grand at Katy Park. The sculptures were created by Sedalia artist Don Luper to honor Lt. George Whiteman...
New sculptures sit on the corner of 24th and Grand at Katy Park. The sculptures were created by Sedalia artist Don Luper to honor Lt. George Whiteman...
The experience known as social painting is seeing explosive growth in cities across the country as people seek to imbibe and relax while rediscovering their creative side.
We make a regular practice at ComicsAlliance of spotlighting particular artists or specific bodies of work, as well as the special qualities of comic book storytelling, but because cartoonists, illustrators and their fans share countless numbers of great pinups, fan art and other illustrations on sites like Flickr, Tumblr, DeviantArt and seemingly infinite art blogs that we've created Best Art Ever (This Week), a weekly depository for just some of the pieces of especially compelling artwork that we come across in our regular travels across the Web. Some of it's new, some of it's old, some of it's created by working professionals, some of it's created by future stars, some of it's created by talented fans, awnd some of it's endearingly silly. All of it is awesome.
Sedalia known as the Queen City of the Prairie, had everything for a wonderful day of family fun.
The Daum Museum is one of the hidden gems of Sedalia. I think it's something we're all familiar with and we've probably been a few times. But the Daum is always changing, growing and expanding to cover different areas of art and technology and innovation.
Folks, if you remember a while back, I got to talk with Barbara Cooney of Camp Blue Sky about all the new activities the kids would be getting into this summer. Well, the camp has been meeting all week long, and I went over to check it out for myself. I started at the Stauffacher Center and made my way all around to the different buildings.
Sitting as still as a statue may not be an appropriate way to describe someone who isn't moving.
We've been mourning the sad loss of 'Calvin and Hobbes' ever since cartoonist Bill Watterson stopped producing the beloved comic strip in 1995. But apparently the strip hasn't gone completely forgotten, since a piece of original 'Calvin and Hobbes' artwork recently broke a record at auction by selling for hundreds of thousands of dollars.


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I'm so genuinely happy to see Pixar back to being Pixar.
After its recent string of sequels, I wondered if success had gotten the better of the studio that brought us "Finding Nemo," "Monsters, Inc." and, of course, "The Incredibles." But after catching the recent press screening for "Inside Out" and now seeing this latest trailer for "The Good Dinosaur," I'm back among the Pixar believers.
The trailer, which is barely a minute long, asks us to imagine a world where dinosaurs weren't destroyed by a six-mile-wide asteroid — as if we haven't been asking ourselves that question in every slow class, movie and meeting since we were 6-year-old children. Then, after giving us a brief look at the character designs and a few action sequences, reveals a clever and compelling logo that I'd like on a T-shirt immediately.
Considering that the best CG dinosaur we've seen on screen in the last 15 years is Rex from the "Toy Story" series, I'm going to put my money on "The Good Dinosaur" when it comes to who will win in the best-2015-dinosaur-adventure competition.


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Women's Brown Shearling and Fox Fur Coat
Last seen for $7724 at LUISA VIA ROMA.
Get notified when it's back…
We check over 450 retailers daily. Be the first to know when it comes back in stock.
Last seen for $7724 at LUISA VIA ROMA.
See more Fendi Coats.
We check over 450 retailers daily. Be the first to know when it comes back in stock.
Shearling and fox fur coat. Zip closing system, stand up collar. Shearling top and long flared sleeves. Fox fur bottom panels. Suede lining. A chromatic collection for Fendi which disclose seasonal colors such as orange, green, blue, bordeaux on bags, tights, inserts etc. Strong shades for a confident woman just like the Fendi sisters, founders of the house. The style is modern even if inspired by the past. Opulence, elegance and nonchalance are key words: woolen coats, jabot tops, wide pants, extra fine sweaters and fur...a lot of fur and skins: in patchwork of colors, blue, brown, chestnut, in mix of materials, fox and sheepskin or with golden glitters. Fall/Winter collection 2011-2012 by Karl Lagerfeld and Silvia Fendi. Color: brown
Fendi items by category | All Fendi items | All Women's Coats


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Founded in 1991, Ariad Pharmaceuticals (NASDAQ:ARIA) is a Cambridge, Massachusetts-based biotechnology company focused on small-molecule drugs that target proteins and pathways involved in cancer.
Ariad's discovery group is a multi-disciplinary team of scientists with expertise in medicinal chemistry, structural and computational drug design, cell biology and cancer genetics, pharmacology, and drug metabolism. These programs build on Ariad's in-house expertise in cell signaling, cancer biology and structure-based drug design to create molecules that overcome resistance to existing treatments. A major focus of the group is to identify inhibitors of protein kinases (enzymes that transfer phosphates between different proteins) that are implicated in specific cancers.
On December 14, 2012, the U.S. Food and Drug Administration (FDA) approved Iclusig (ponatinib) to treat adults with chronic myeloid leukemia (CML) and Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL), two rare blood and bone marrow diseases. Iclusig is Ariad's first approved product.
The company is also studying AP26113, another molecularly targeted medicine, as a treatment for certain forms of lung cancer.
In addition to the development of these two drugs, Ariad is collaborating with Merck (NYSE:MRK) in the development of Taltorvic (ridaforolimus) for multiple cancer indications. The company is also partnering with Bellicum Pharmaceuticals for AP1903, an investigational dimerizer drug that is being evaluated in patients with prostate cancer and in patients with hematologic malignancies who develop graft-versus-host disease (GVHD), a complication of hematopoietic stem cell transplants (HSCT).
Ariad's highly touted Iclusig was approved more than three months before the product's prescription user fee goal date of March 27, 2013, the date the FDA was scheduled to complete review of Ariad's drug application for the drug. The FDA reviewed Iclusig under the agency's priority review program (PRP). PRP provides an expedited six-month review for drugs that may provide a safe and effective therapy when there are no other satisfactory therapies available, or for drugs that are a significant improvement compared to marketed products. Iclusig was also granted orphan product status because the drug is intended to treat a rare disease or condition.
The good news came with some bad news. The FDA's Iclusig approval had an unexpected caveat. The agency required that the drug carry a boxed warning stating that Iclusig may cause blood clots and liver toxicity. As a result, Ariad's stock dropped over 20% percent following the warning box news.
Iclusig is a kinase inhibitor designed using Ariad's computational and structure-based drug design platform. The drug works by blocking specific proteins that promote cancerous cells. The drug is taken once a day to treat patients with chronic, accelerated, and blast phases of CML and Ph+ ALL whose leukemia is resistant or intolerant to tyrosine kinase inhibitors (TKIs). Iclusig targets CML cells that have a particular mutation, known as T315I, which makes these cells resistant to currently approved TKIs. Iclusig is the only TKI that is effective in CML and Ph+ ALL patients with this mutation.
CML occurs when too many white blood cells are produced due to a genetic abnormality that produces the BCR-ABL protein. CML typically evolves to the more aggressive phases referred to as accelerated phase and blast crisis.
Ph+ ALL is a subtype of acute lymphoblastic leukemia that carries the Ph+ chromosome that produces BCR-ABL. Ph+ ALL has a more aggressive course than CML. Ph+ ALL is often treated with a combination of chemotherapy and tyrosine kinase inhibitors. The BCR-ABL protein is expressed in both CML and Ph+ ALL.
According to the American Cancer Society, about 5,430 new cases were diagnosed with CML in 2012, and about 610 people died from the disease. CML accounts for a little over 10% of all new cases of leukemia. The average person's lifetime risk of getting CML is about one in 625. This disease is slightly more common in men than in women. It is also more common in whites than in African-Americans. The average age at diagnosis of CML is around 65 years. Over 50% of cases are diagnosed in people aged 65 years and older. This type of leukemia mainly affects adults, and is only rarely seen in children.
The American Cancer Society notes that most people with CML are now surviving at least five years after diagnosis, but because the highly effective drugs are still fairly new, the average survival rate of people with CML is difficult to estimate.
According to the National Cancer Institute, about 6,050 people were diagnosed with acute lymphoblastic leukemia (ALL) and 1,440 men and women died from the disease in 2012. The Philadelphia chromosome is present in approximately 20% to 30% of adults with ALL.
Iclusig is the fifth TKI to be approved by the FDA. In May 2001, Novartis AG's (NYSE:NVS) Gleevec (imatinib) was the first drug to be approved by FDA in May 2001 to treat CML. Novartis' Tasigna (nilotinib) was approved in October 2007 for the treatment of adult patients with newly diagnosed, chronic phase Ph+ CML. Bristol-Myers Squibb's (NYSE:BMY) Sprycel (dasatinib) was approved by the FDA in October 2010. The FDA approved Pfizer Inc.'s (NYSE:PFE) Bosulif (bosutinib) for leukemia patients who have failed on other therapies in September 2012 and Teva Pharmaceuticals' (NYSE:TEVA) Synribo (omacetaxine mepesuccinate) in October 2012 to treat various phases of CML.
Talon Therapeutics' (OTC:TLON) Marqibo (vincristine sulfate liposome injection) was approved in August 2012 to treat Philadelphia chromosome negative ALL. Iclusig is approved for patients who don't respond to treatment with Gleevec, Tasigna. or Sprycel.
Ariad hopes to expand the indication of the drug so that it can be used as a first-line therapy. On December 10, 2012, the company announced data from its Phase 1 and pivotal Phase 2 trials of Iclusig in heavily pretreated patients with resistant or intolerant CML or Philadelphia chromosome-positive ALL. The studies found that 51% of chronic-phase CML patients in the Phase 1 trial achieved a major molecular response (MMR) with a median follow-up of 30 months, and 34% of chronic-phase patients achieved MMR in the trial with a median follow-up of 15 months.
Ariad and the United Kingdom National Cancer Research Institute (NCRI) CML Working Group are collaborating in a Phase 3 trial assessing the impact of switching CML patients being treated with a first-line tyrosine kinase inhibitor to Iclusig when these drugs fail or achieve an unsatisfactory response. NCRI expects to begin enrollment in the trial of 1,000 patients at approximately 172 clinical research sites in the United Kingdom during the second quarter of 2013.
Ariad has estimated that about 2,500 U.S. patients will stop other leukemia drugs because they have become resistant or intolerant to these drugs. Those patients are eligible for Iclusig. The drug will be priced at about $115,000 per patient, per year. Some analysts estimate that Iclusig will generate about $800 million in annual sales.
Since Ariad was expecting to receive Iclusig approval from the FDA, the company hired and trained its U.S. sales force enabling Ariad to begin marketing the drug immediately after the agency approved the drug. Despite these proactive efforts, the commercial launch of Iclusig was not spectacular with only 45% of Iclusig prescriptions being captured during the first six weeks on the market. The company predicts the capture rate will increase to 70% in the near future.
European Union (EU) regulators are expected to rule by mid-2013 on Ariad's application to sell the drug in Europe. The company has established a base in Lausanne, Switzerland to facilitate Iclusig sales in the EU. In Europe, Ariad has made major strides in executing on its commercial plan with the initiation of early-access programs and the implementation of pricing and reimbursement activities. The company has established its European supply chain, and hired key personnel for its European leadership team. Ariad plans to be commercial-ready in Europe on July 1, 2013.
Ariad plans to also file for approval in Canada, Switzerland, and Australia in the second half of this year. Based on the results of the ongoing Phase 1/2 trial of Iclusig in resistant and intolerant CML in Philadelphia-positive ALL in Japan, Ariad expects to file for regulatory approval in Japan in mid-2014.
AP26113, is a small-molecule that has exhibited activity as a potent dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR) in preclinical studies. Discovered by Ariad scientists, this compound targets unique genetic features of cancer cells similar to ponatinib.
Dosing continues in the ongoing Phase 1/2 clinical trial of AP26113, which is now being administered at a once-daily oral dose of 300 mg. Clinical investigators are enrolling patients at seven sites in the United States. The company also plans to open additional sites in Europe. Patients with non-small cell lung cancer (NSCLC) are now exclusively being enrolled in the trial.
Planning is actively underway for pivotal trials of AP26113 to start in 2013 in ALK-positive NSCLC patients. Ariad will also plan to begin a pivotal trial in patients with EGFR-mutant NSCLC who have failed prior EGFR inhibitor therapy, dependent on the clinical findings from the Phase 2 portion of the currently ongoing trial.
On September 29, 2012, Ariad announced the initial clinical results of AP26113, in patients with advanced NSCLC from the ongoing trial. Researchers found that AP26113 has impressive anti-tumor activity in ALK+ NSCLC patients. Researchers also saw a partial response in a patient with EGFR-mutant lung cancer and acquired resistance to Roche/Genentech's (OTCQX:RHHBY) and Astellas' Pharma's (OTCPK:ALPMY) Tarceva (erlotinib) in the Phase 1 dose-escalation portion of the trial. The trial is expected to be completed in September 2015.
In July 2007, Ariad and Merck entered into a collaboration to develop Taltorvic (ridaforolimus) for several potential cancer indications.
Ridaforolimus is an investigational small-molecule inhibitor of the protein mTOR, a protein that acts as a central regulator of protein synthesis, cell proliferation, cell cycle progression and cell survival, integrating signals from proteins, such as PI3K, AKT and PTEN, known to be important to malignancy.
At the start of the collaboration, Merck made a $75 million upfront payment to Ariad, Merck has also paid Ariad $53.5 million in milestone payments for the initiation of Phase 2 and Phase 3 clinical trials of ridaforolimus, in addition to paying a 50% share of Taltorvic development, manufacturing and commercialization costs.
In May 2010, Ariad and Merck announced the restructuring of the partnership. Under the new collaboration framework, Ariad granted Merck an exclusive license to develop, manufacture and commercialize ridaforolimus in oncology. Merck assumed responsibility for Taltorvic activities, including clinical trials and regulatory filings.
Ariad received a $50 million upfront cash payment, as well as approximately $19 million in cash to retroactively fund the cost of ridaforolimus development from January through April 2010. Under the new agreement, Merck will fund 100% of Taltorvic development, manufacturing and commercialization costs. Ariad is also eligible to receive regulatory and sales milestones and tiered double-digit royalties on global sales of ridaforolimus.
In January 2011, Ariad shares increased more than 30% when it was reported that ridaforolimus met its endpoints in a Phase 3 trial as a treatment for sarcoma.
In the United States, sarcomas account for approximately 1% of all adult solid malignancies and approximately 15% of pediatric cancers. According to the National Cancer Institute, there were an estimated 11,280 new cases of adult soft tissue sarcoma in 2012. Approximately 3,900 patients will die from the disease this year. There are few options for the treatment of sarcomas. Standard therapy includes surgery, chemotherapy, and radiotherapy. The most frequently used treatment for advanced disease is chemotherapy with anthracyclines such as Johnson & Johnson's (NYSE:JNJ)/Janssen's Doxil (doxorubicin), alkylating agents, such as, ifosfamide and dacarbazine, and platinum compounds such as cisplatin and carboplatin, or combinations of these agents.
Data from the SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Ridaforolimus) trial, found that the drug induced a significant 28% reduction in the risk of disease progression compared to placebo.
In March 2012, the FDA's Oncologic Drugs Advisory Committee (ODAC) voted 13 to 1 against Taltorvic to treat sarcoma, a rare cancer that occurs in the bones and soft tissue, but recommended that the FDA approve GlaxoSmithKline's (NYSE:GSK) Votrient (pazopanib) for that indication by an 11 to 2 vote. Votrient stopped sarcoma from spreading in soft tissue three months longer than placebo, while Taltorvic stopped progression of the disease three weeks longer than placebo. Patients in clinical trials experienced heart, kidney and liver disorders.
The committee rejected Taltorvic because they felt that the benefits of the drug did not outweigh the risks. Approximately 50% of patients discontinued Taltorvic therapy due to side effects. The high rate of adverse reactions and trial withdrawals compelled the panel to vote against approving Taltorvic.
In June 2012, Merck announced that the FDA would not approve Taltorvic unless Merck conducted further testing that finds the major side effects, such as lung irritation, kidney failure and high blood pressure, were worthwhile for patients
In November 2012, the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (OTCQB:CHMP) also found that there was insufficient data available to support the approval of Taltorvic for maintenance treatment of patients with soft tissue sarcoma or primary malignant bone tumor in the European Union. As a result, Merck withdrew its European application of ridaforolimus for these indications. Merck insisted that this withdrawal does not change the company's commitment to the ongoing clinical trials with ridaforolimus for other indications.
Merck is currently conducting a Phase 1 trial for Taltorvic given with MK-2206 or MK-0752 as a therapy for advanced cancer, a Phase 2 trial comparing ridaforolimus and exemestane with ridaforolimus, dalotuzumab and exemestane in breast cancer, a Phase 1 study comparing dalotuzumab alone and with ridaforolimus in pediatric participants with advanced solid tumors, a Phase 1 study comparing ridaforolimus with cetuximab in advanced head and neck cancer, non-small cell lung cancer and colon cancer, a Phase 1 study of ridaforolimus in pediatric patients with advanced solid tumors, a Phase 1 study of carboplatin/Taxol/ridaforolimus in endometrial and ovarian cancers, and a Phase 1 study of ridaforolimus and vorinostat in patients with advanced renal cell carcinoma.
Licensed to Bellicum Pharmaceuticals, Ariad's investigational dimerizer drug, AP1903, is being evaluated in patients with prostate cancer and in patients with hematologic malignancies who develop graft-versus-host disease (GVHD), a complication of hematopoietic stem cell transplants (HSCT).
Clinical proof of concept data for the use of AP1903 to treat GVHD was published in the New England Journal of Medicine in 2011.
AP1903 was discovered and developed by Ariad scientists, as a part of the company's ARGENT technology platform which combines chemistry and genetics to allow specific cell-signaling and gene-expression events to be chemically activated in whole animals and cultured cells. The technology platform includes a portfolio of distinct small-molecule "dimerizer" compounds optimized for specific applications. Dimerizers bring specific proteins together in cells.
Ariad has an equity stake in Bellicum and is eligible to receive milestones on regulatory and clinical progress and royalties on future product sales. Bellicum is responsible for all manufacturing, regulatory and clinical activities and holds the investigational new drug applications for these programs.
The first quarter of 2013 was the first quarter that includes Iclusig sales revenue. On February 25, 2013, Ariad reported that their net loss for the fourth quarter ended December 31, 2012 was $60.5 million, or $0.36 per share, compared to a net loss of $51.8 million, or $0.38 per share, for the same period in 2011.
Net loss for the full year 2012 was $220.9 million, or $1.34 per share, compared to a net loss of $123.6 million, or $0.93 per share, for the full year 2011.
As of December 31, 2012, cash, cash equivalents and marketable securities totaled $164.4 million, compared to $306.3 million at December 31, 2011. In January 2013, Ariad raised net proceeds of $310 million in an underwritten public offering and sale of approximately 16.5 million shares of our common stock.
The company forecasts that their cash, cash equivalents and marketable securities will be between $195 million and $205 million at the end of 2013, Ariad is confident they have sufficient funds to continue operations into the fourth quarter of 2014
Conclusion: Buy
After the FDA ruled that Iclusig must include a box warning for arterial thrombosis and hepatotoxicity, virtually all analysts covering Ariad continued to recommend Ariad as a wise investment, although several firms lowered their price targets for the stock due to undisclosed safety issues.
After the FDA vote, the Jefferies Group maintained their "Buy" rating, but chopped their price target on Ariad to $23 from $27. On February 26, 2013, Jefferies boosted their target price on Ariad from $23.00 to $25.00. However, Barclays Capital decreased their price target on Ariad from $30.00 to $29.00 and rated the stock "overweight." Stifel Nicolaus also cut their price target on shares of Ariad Pharmaceutical from $27.00 to $26.00 on February 14. They have a "buy" rating on the stock. On February 8, JMP Securities initiated coverage on Ariad with an "outperform" rating on the stock.
In January 2013, Oppenheimer advised that they conducted a survey of US physicians following the FDA's approval of Iclusig. The survey found that only "a 15% minority of physicians who find Iclusig's arterial thrombosis and liver toxicity to be prohibitive." Oppenheimer has a "Perform" rating on Ariad and remains confident that Iclusig represents "a significant long-term market opportunity." UBS AG maintained their "Buy" rating but lowered their target from $29 to $26. Brean Capital also kept their "Buy" rating, but lowered their price target from $35 to $29. RBC Capital reiterated their "outperform" rating. On January 14, Leerink Swann raised their price target from $23 to $28 and maintained their "Outperform" rating.
On December 25, Ariad Pharmaceutical had its "Overweight" rating reiterated by analysts at Barclays Capital who have a $30.00 price target on the stock. On December 17, 2012, William Blair reaffirmed their "outperform" rating and put a $28.00 target on the stock. Analysts at the Maxim Group lowered their price target to $24, but maintained their "Buy" rating on the stock. On December 14, Citigroup reiterated their "Buy" rating and have a $31.00 price target. On December 14, Cowen also reaffirmed "outperform" rating.
Iclusig is frequently referred to as a "first in class" drug. While the FDA has only approved Iclusig for leukemia patients who are resistant or intolerant to other drugs, research is ongoing which may enable Iclusig to expand the label for other indications, which would provide Ariad with an opportunity to gain a larger portion of the estimated $4.5 billion annual CML market now dominated by Novartis with their Gleevec and Tasigna products and Bristol-Myers Squibb with their Sprycel drug.
The optimal first-line treatment for patients with newly diagnosed chronic-phase CML is controversial. When used as first-line treatments, some studies have found that Tasigna, Sprycel and Bosulif have all produced better response rates than Gleevec.
In July 2012, Ariad launched a Phase 3 trial testing Iclusig head to head with Gleevec in people newly diagnosed with CML. Positive results from that trial could propel Iclusig to blockbuster drug status. Harvey Berger, Ariad's CEO, has predicted that Iclusig could generate $1.5 billion in projected revenue if the company can broaden the label to include its use as an initial treatment for leukemia.
Due to its strong oncology pipeline, some analysts believe Ariad could be a potential acquisition candidate for such pharmaceutical industry giants as Celgene (NASDAQ:CELG), Amgen (NASDAQ:AMGN), Eli Lilly (NYSE:LLY), Merck and Johnson & Johnson . Others have speculated that Ariad could be a prime target for Gilead Sciences (NASDAQ:GILD), a company that "has spent $1.2 billion in two years to buy blood cancer drugs" and "it's looking for more." Ariad insists that the company is not for sale and they are determined to remain independent.
Remaining independent is a key reason why many Ariad investors are so excited about the company. While most small cap and mid cap biotech firms must partner with pharmaceutical giants like Pfizer or Merck to help pay for the development of promising investigational drugs, Ariad has been able to raise the necessary funds to develop Iclusig and AP26113, and thus maintain worldwide rights for its two most promising drugs.
With the US approval of Iclusig, Ariad is transforming from a biotech research firm to a revenue generating, commercial pharmaceutical company. It has taken over 20 years for Ariad to get here. Recently, the company's workforce has more than doubled to about 300 employees. Ariad has opened a European headquarters in Lausanne, Switzerland. There is plenty to be excited about in this $3.5 billion market cap company. With these recent developments, Ariad can not only save lives, but also offer the prudent investor a lucrative return.
Disclosure: I am long AMGN, CELG, GILD, MRK. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.


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Get dining news including restaurant closures and qualify for giveaways.
Fast, fresh, and healthy food located in the heart of New Westminster!
The falafel wraps and baklava are outstanding and very reasonably priced. Everything at the restaurant is made lovingly and fresh by the friendly and effervescent owner. The restaurant may look ordinary and sterile, but this is more than made up for by the warmth of the employees. I was so impressed that after gorging myself on a filling falafel, I got four spinach pies to go. My boyfriend and I aren't even huge fans of baklava, but we found hers delicious, addictive, and in a class of its own. If you're looking for an authentic falafel experience (which is painfully rare in these parts), go to Taza! This is the real thing.
|Lalibela Ethiopian Restaurant (38 m)
|Hon's Wun Tun House (43 m)
|Taqueria Playa Tropical (52 m)
|Kojima Sushi (64 m)
|Java Jazz Cafe and Bistro (69 m)
|Rivers Reach Pub (87 m)
|Thai Box 2 Go (89 m)
|Sixth Street Grill, The (90 m)
|Indian Star Restaurant & Sweets (115 m)
|AFG Kabul Bakery (224 m)


text: Just a quick question. I know guards are meant to guard and be defensive. But i don't like the warriors because there so many models and i don't think they do allot besides getting hit in the face The knights i like better but they get to far ahead of th me rest. Sooooo My question is : Can i use the guards for an infantry unit or is that gonna be a total fail?


text: Before we found this site my other half went bear hunting and bagged a small bear. Which we took to a meat processor. We had some made into ground bacon and some into Breakfast links.. Neither of them have much taste..and the little taste they do have .. well lets say isn't my forte....Don't get me wrong it isn't the meat I actually prefer to eat the bear meat over the ven.. How or what can we do to improve these and make them into something we want to eat... Can I smoke them into sticks and if so would I need to cure them ?? Or anybody else have any ideas...??? Thank goodness we found you guys before deer camp Because the Ven. Bacon we made with your guidance turned out awesome.. Working on the dried venison, Bearcarver posted now..which I'm sure will be gone as soon as it is completed and believe me Miracle whip & white bread are already lined up..and I'm salivating thinking how good it's going to be..


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Online about 1 year ago
Rent budget
Preferred stay length
Move date
Easy to get along with, I can see the positive side of most situations.
I tidy up after myself. I'm going to be doing a micro brewing corse, and would be willing to share any information on how to brew a great beer. Well that alone should do it. So I'll stop talking up myself now.


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Want to Quit Smoking? This Easy Cure Might Surprise You!
The Dangers of Smoking
A Surprising Cure
If you smoke and have ever tried to quit, you understand how difficult it is to quit smoking. Nicotine cravings are hard to ignore. Luckily, there is an easy home remedy that can help curb these cravings. It's as simple as mixing baking soda with water, and it's even recommended by the Mayo Clinic.
An acidic body is prone to addiction. Baking soda is highly alkaline, so it effectively neutralizes toxins and reduces the acidity in your body. A body that is more alkaline is less likely to crave nicotine.
How to Use Baking Soda to Quit Smoking
Pages: 1 2


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Ziggs Build Guide by Tactical Cookies
This build has been archived and is for historical display only.
PLEASE NOTE: This build has been archived by the author. They are no longer supporting nor updating this build and it may have become outdated. As such, voting and commenting have been disabled and it no longer appears in regular search results.
We recommend you take a look at this author's other builds.
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This guide has not yet been updated for the current season. Please keep this in mind while reading. You can see the most recently updated guides on the browse guides page.
Thank You!
Your votes and comments encourage our guide authors to continue
creating helpful guides for the League of Legends community.
Ziggs Build
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Chapter 1
Mr. Hexplosive, Reporting For Duty!
Ziggs is, and always should be, built for AP. His spells are amazing, having a classic Fuse Bomb, Satchel Charges (C4), Minefields, and best of all, a Nuke! However, here are some things to take note of:
- The Satchel Charges are very hard to use, but can be devastating if used correctly
- His spells take up a lot of mana, so this build fortifies on it
- Ziggs is reasonably low in health, so health items are later built in the game
The Bouncing Bomb is very effective against singular champions, and especially minions. I reccomend maxing this spell out first. It is great in Team Fights and against fleeing enemies.
This spell is notorious for being hard to master, and a nuisance to use. I reccomend maxing this out last, as it rarely comes in handy and isn't neccesary, despite how awesome it looks. The fuse time and radius is the main issue, so timing and placement is key. I normally use this as an escape tool, or just spam it in Team Fights.
This spell is somewhat like the Satchel Charge. It is hard to use, but it is actually pretty handy in many situations. I reccomend maxing it out after the Bouncing Bomb, only because it does much less damage. I usually implement this while I'm fleeing an enemy, or rushing a solo champion. I often mix this spell with Exhaust, slowing the champion down massively, allowing me to use the Bouncing Bomb, and my ultimate (if neccesary).
MEGA INFERNO BOMB [ultimate]
This may be one of the most effective, and not to forget devastating ultimates I've seen in a champion. It's really hard to find a place to start with such a good spell like this. You can launch this dreadful nuke an enourmous distance, around 1/3 of the map. It is great for Team Fights, assisting team mates, or decimating an unreachable fleeing enemy.
Thanks for taking the time to reading this guide, I put a lot of time and effort into it, so could you please vote this guide up? (:
-Tactical Cookies :P


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Contact Info / Websites
All 26 game Reviews
No Time to Explain
Rated 4.5 / 5 stars
The game was actually kind of challenging in places, but the highlight for this game is the humour. Couldn't stop laughing at every line, great job guys :)
Shift: Freedom!
Rated 3 / 5 stars
Yay more Shif- no wait, what's that?
It's fun, but everything that made shift awesome seems to be taken out of this one sadly. The new design, as nice as it may be, doesn't suit it as well as the past version, which was just simple colours and resembled traffic signs and what not, and the wait between loading levels is beyond unecessary, you find your self sitting there for 2 or 3 seconds as it shows an animation of this bigheaded character crouching(?) and going though the door, which wasnt needed at all, i mean we can see him going through the door just by looking at it on the level, why do you need to make it a movie sequence every time? Also the new addition of having to hold down R to restart seemed like a smart idea at first, but it soon becomes very irritating when you want to try again faster.
But still, don't get me wrong i was happy to see a new shift game and new levels, but these new changes didn't make me as happy.
Letz Maek A Flash Gaem
Rated 4 / 5 stars
That was far too much fun for what it was. Really liked it :D
Great! Now go out with your newly acquired knowledge and GO! MAEK THOES FLASH GAEMZ! And maybe one day you will maek one as awesome as the one you just played. (Kidding, but thanks for the review, big fan btw)
Miami Shark
Rated 4.5 / 5 stars
Amusing & Addictive, a deadly combo
This game was looking good until i saw a shark pull down a plane with it's teeth. I think i may never recover from such a sight of sheer awesome.
Toss the Turtle
Rated 4.5 / 5 stars
The simplest ideas are always the best
Great work all around, especially the artwork. The only improvement i could possibly imagine would be to have more animation, maybe with the turtle writhing in pain as he hurtles through the sky :P
Rated 4.5 / 5 stars
Loved it
I really loved this game, the graphics were unique and so were the weapons and enemies. The only flaw with the game is i found it to get easier as it went along, rather than harder, because the weapons attack range gets wider meaning you can just stay in one position killing them all as they come on by pushing shoot over and over. However the bosses were just sheer gold :D
Ragdoll Cannon: Remake
Rated 4 / 5 stars
Wow that was a fun 20 mins :D
Great idea and good actionscript, i had a lot of fun!
Only improvement i can suggest for next time is better graphics :D
Ms. Pacman
Rated 4 / 5 stars
Not often i play a decent Pac-man flash version
Awesome game, i got third.. Soon to be smashed off there though xD
Ignite people on Fire
Rated 4.5 / 5 stars
Great work!
Simple and Crazy, just the way web games should be :D
I especially like how much you have improved it from your last version!
Pico Blast
Rated 4 / 5 stars
Good god i suck at this game xD
Nice to look at and i just got past that first boss before i died (yeah i really am that terrible).
From what ii played the only thing that really annoyed me was the fact Pico took so long to get up once he died, i was beating the buttons sensely trying to get him to stand up but there didnt appear to be any quicker way to stand.. unless theres some control i didn't see?
Anyway, great job!


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Tortuga tow truck
Delivered this girls Huffy Corvair bike with my rust tow bike. Rusty has a half gallon gas tank in frame. 26x3.00 tires. I like riding this bike to the Casino del Sol way across town on the indian reservation.
popunas, Feb 28, 2009
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I Heart Newmarket - arts activities
Date: 13 February 2017 10:00:00 - 18 February 2017 16:00:00
Time: 10:00 - 16:00
Location: The Guineas Shopping Centre, CB8 8EQ
During February half term Spinning Wheel Theatre will be in residence in Newmarket running a series of creative activities celebrating the culture and heritage of Newmarket. The project will unearth and reveal the personal histories and legacies of the area, and will actively involve residents in exploring and sharing their stories and memories with the rest of the community, encouraging cohesion and unity across generations and cultures. Free to participate http://www.spinningwheeltheatre.com/iheartnewmarket email@example.com