text:
|Home | About | Journals | Submit | Contact Us | Français
The use of MRI to monitor immune cell infiltration into various pathologies is well established. In an effort to boost the magnetic material within immune cells, this work attempted to label resting monocytes within bone marrow, in mice, by intravenous administration of micron-sized iron oxide particles (MPIOs), similar in fashion to the administration of (U)SPIO.
MPIOs were incubated with various immune cells both in culture, and in whole blood. Flow cytometry and histology were used to analyze magnetic cell labeling. Also, MPIOs were injected intravenously into mice. In vivo, high-resolution 3-D MRI was performed on mouse legs, and signal changes were quantified. Flow cytometry and histology were used to analyze magnetic cell labeling of bone marrow resident cells.
It is demonstrated here that monocytes and neutrophils can indeed endocytose MPIOs both in cell culture and ex vivo in whole blood. However, despite rapid accumulation of MPIOs within the bone marrow following injection, MPIOs did not label monocytes or any other hematopoietic cell type in the marrow. Hypotheses are drawn to explain these results in light of recent usage of MPIOs for immune cell tracking.
Systemic administration of various MPIO formulations showed that MPIOs arrive in bone marrow rapidly following injection and remain there for at least 7 days. Data also shows slow clearance of some particles from the tissue over this period. While MPIOs can efficiently label monocytes in culture and in whole blood ex vivo, they were not found to label bone marrow resident monocytes.
The use of MRI to track monocyte infiltration is well established in a number of pathologies. These include diseases and injuries of the brain such as stroke and MS (reviewed in [1]), diseases of the heart and vessels such as atherosclerosis [2] and myocardial infarction [3], organ transplantation [4], and arthritis [5], among others. The general experimental protocol starts with an injury/disease already present. For instance, a stroke has already been created, or a plaque already exists, or an organ has been transplanted. Thus, there already exists an activated immune system responsive to the malady. Next, iron oxide nano-particles are administered intravenously. In nearly every case, ultrasmall superparamagnetic iron oxides (USPIOs; 30–50 nm) have been administered, rather than SPIO (100–200 nm). Lastly, MRI is performed, commonly 24 h post USPIO delivery. Dark contrast in the MRI at the site of the injury/disease is evidence of infiltrated immune cells harboring iron particles. The most commonly expressed hypothesis for cell labeling is that circulating monocytes can endocytose material from the blood and/or bone marrow-borne monocytes pick up USPIO prior to leaving the marrow. In contrast to other types of MRI-based cell tracking studies, the use of MRI to monitor the migration of monocytes, labeled in vivo with USPIO, has been performed many times in humans [6, 7].
There are at least two variations on this generalized experimental protocol which could benefit medical research. The first is the labeling of resting monocytes prior to activation by disease or injury. This would enable visualization of the earliest phases of a confirmed injury or disease, which, for many diseases, provides a unique window of opportunity for treatment. The second is the use of magnetically labeled cells of the innate immune response (e.g., neutrophils, dendritic cells, or macrophages) to act as sentries, i.e., to survey the body for unknown maladies. This would be especially important in the identification of small tumors or metastases. In both cases, due to the low number of expect cells which migrate to the disease/injury, cells would likely be required to possess enough magnetic material in low numbers of cells as to non-ambiguously identify diseases.
Micron-sized iron oxide particles (MPIOs) have emerged as an alternative contrast agent for cellular MRI [8, 9]. These particles have three major advantages over (ultra) small superparamagnetic iron oxide (U)SPIOs for magnetic cell labeling. First, these particles more efficiently package iron, that is, these particles have higher iron content based on volume. Secondly, MPIOs have higher r2* molar relaxivity than (U)SPIOs due to the physical size of the magnetic entity, forcing relaxation towards the static dephasing regime [10]. Thirdly, MPIOs have been shown to readily and easily label a variety of phagocytic cell types without the need for complexation with transfection agents or potentially harmful electroporation [9]. Indeed, it has been demonstrated that single cells can be detected in vivo using MPIOs [11]. Thus, if MPIOs can label monocytes in vivo, these particles may be enabling in detecting low numbers of homing monocytes in vivo.
MPIOs do have a major disadvantage compared with (U) SPIOs. MPIOs are efficiently cleared from the circulation by the liver and spleen, and by the kidney to some extent. This is challenging in that in order to label bone marrow-borne monocytes, MPIOs need to arrive in the bone marrow. However, work using systemically delivered fluorescent 0.5-μm latex beads has demonstrated robust labeling of monocytes in vivo [12]. Furthermore, Wu et al. [4] and Yang et al. [3] have demonstrated MRI detection of magnetically labeled monocyte infiltration in organ rejection and myocardial infarct models, respectively. Lastly, a recent study demonstrated that resting monocytes can be labeled in vivo with small fluorescent iron oxide nanoparticles prior to injury [13]. Taken together, these studies provided motivation to determine whether systemically delivered MPIOs can in fact reach bone marrow and if they can label resting monocytes.
MPIOs were 1.63-μm COOH-functionalized (n=4), 1.63-μm NH2-functionalized (n=3), and 0.86-μm COOH-functionalized (n=3; Bangs Labs). Zeta potential of 1.63-μm COOH and NH2-functionalized were measured on a ZetaPALS in DI water, pH 7.4. All particles were styrene-/divinylbenzene-coated with magnetite content of 43% for 1.63 μm to 46% for 0.86 μm, and green fluorescent.
Neutrophils and monocytes were labeled with MPIOs both in culture and in whole blood. Rat whole blood was harvested. Blood was then mixed with an equal volume of dextran/saline solution (3% dextran T-500 (Pharmacia) in 0.9% NaCl) and incubated in upright position ~20 min at room temperature. The upper leukocyte-rich plasma layer was aspirated and cells were pelleted from the plasma by centrifuging at 250×g for 10 min at 5°C. Cells were then resuspended in 0.9% NaCl, layered on top of 10 mL of Ficoll-Hypaque solution, and centrifuged at 400×g for 40 min at 20°C, with no brake. Mononuclear cells were obtained by aspirating the cloudy band of mononuclear cells at the saline/Ficoll-Hypaque interface. The top saline layer and Ficoll-Hypaque layer were then aspirated, leaving the neutrophil/RBC pellet. Residual RBCs were removed by subjecting cells to hypotonic lysis in 0.2% NaCl for exactly 30 s. Isotonicity was restored by adding 1.6% NaCl. 1×106 neutrophils and monocytes were plated separately in 6-well plates in RPMI supplemented with 10% FBS, 1% penicillin/streptomycin, and 1% l-glutamine. MPIOs were added to the cells at a concentration of 20 MPIOs/cell (33 μg/mL Fe) and allowed to incubate overnight. Cells were then spun onto slides via cytospin cytocentrifuge and stained with Wright Giemsa.
For labeling of neutrophils and monocytes in whole blood, prior to cell isolation, MPIOs were added to the blood at a concentration of 20 MPIOs/cell (assuming ~1.5×106 neutrophils or monocytes/mL; 33 μg/mL Fe) and incubated at 37°C for 3 h. Then, red blood cells were lysed with ACK lysis buffer for 5 min at room temperature, after which all remaining cells were collected by centrifugation. Cells were resuspended in the same growth medium as above and cultured overnight. This was done to isolate macrophages by their affinity to adhere to plastic, with B and T lymphocytes remaining suspended. The next day, non-adherent cells were washed away and adherent cells were scraped from the dish. Following collection by centrifugation, cells were stained with anti-mouse CD11b antibody with direct Cy5 conjugation. Flow cytometry (Becton Dickson LSR II) was performed for quantification of the number of double positive green fluorescent (MPIO-labeled) and Cy5 fluorescent (monocytes/macrophages) cells. Some cell samples at the 3-h time point were spun onto slides via cytospin cytocentrifuge and stained with Wright Giemsa.
Four-week-old CD-1 mice were injected intra-ocularly with various quantities of different MPIO preparations. Injection volumes were 30 (1% solids), 100 (1% solids), and 150 μL (2% solids), delivering 100, 330 or 1,000 μg iron, respectively, to ~10 g mice. Animals then underwent in vivo MRI immediately after injection, at 6 h post injection, then again at 1, 2, 4, and 7 days post-injection. MRI consisted of 3D gradient echo (TR=100 ms, TE=10 ms, 1 average) of the femur at 50 μm isotropic resolution (384×192×192 over 1.92×0.96×0.96 cm) at 4.0 T (Bruker Biospec) using a homebuilt solenoid coil. Animals were anesthetized with 1% isoflurane delivered by nosecone with respiratory monitoring accomplished with a respiratory pillow and gating system (SA Instruments). MRI data analysis was performed in Amide.
At either 2 or 7 days post-injection, animals were euthanized. Legs were removed from animals and sterilized with ethanol. Femurs were dissected and the distal end and femoral head were carefully removed with bone scissors. Using a 25-G needle, bone marrow was aspirated from both femurs into 2% fetal bovine serum in phosphate-buffered saline (PBS). Cells were washed once with 2% fetal bovine serum in PBS. Total bone marrow was stained for CD45 (cells of hematopoietic origin) or CD11b (specific for monocytes/macrophages) using Pe-/Cy5-conjugated rat anti-mouse CD45 and Cy5-conjugated rat anti-mouse CD11b, respectively. Flow cytometry was performed at 2 and 7 days post-injection to measure the total number of bone marrow cells double positive for green fluorescent MPIOs and red fluorescent cells of interest. For some animals, femurs were dissected, decalcified, and cryosectioned for histology. Toluidine staining was performed on some sections to reveal cellular architecture. For some animals, liver, spleen, and kidneys were removed and processed for frozen sectioning. Optical and fluorescence microscopy on cell slides and tissue sections were performed with a Leica Fluorescent MZ FLIII stereomicroscope.
The first set of studies sought to identify whether blood resident phagocytic cells could endocytose MPIOs following isolation and culture. Figure 1a, b shows optical (1a) and fluorescent (1b) microscopic images of monocytes labeled in cell culture with MPIOs following cell isolation. It can be seen that monocytes are nearly completely full of MPIOs. Neutrophils could also be labeled (data not shown). Next, monocytes and neutrophils were tested for labeling with MPIOs in whole blood. Of the cells that were subject to flow cytometry (adherent cells from whole blood), 65.6% were positive for CD11b, meaning that these were monocytes/macrophages, and of those, 30.5% were double positive for MPIO labeling. Figure 1c shows dual fluorescent/optical microscopic images of monocytes (1c) and neutrophils (1d) containing MPIOs following incubation of MPIOs in whole blood. It can be seen that in these experiments, versus labeling of isolated monocytes and neutrophils in culture, cells endocytosed lower numbers of particles.
Following the success of in vitro labeling of monocytes, attempts were made to label monocytes directly in situ with MPIOs. MRI was used to investigate the contrast evolution in the femur to report on the arrival and location of the particles. In vivo MRI of live mouse femur was accomplished at 50 μm isotropic, with scan times of 61 min, aided by a robust restraint system and a dedicated, tight-fitting solenoid coil.
MRI of femurs prior to injection showed bright contrast, with dark contrast at the ends of the bones due to the trabeculae (Fig. 2a). MRI of femurs as early as 1 h post-injection demonstrated widespread uptake of MPIOs throughout the bone marrow, as evidenced by dark contrast in T2*-weighted gradient-echo MRI (Fig. 2b). The degree of bone marrow contrast was dependent on the amount of particles injected, with 30-μL injections producing ~50% overall drop on bone marrow signal intensity and 100 μL and higher nearly depleting signal intensity in the marrow. For animals injected with the highest dose of MPIOs, contrast in the marrow continued to increase, even up to 4 days post-injection (Fig. 2c–f). This data is quantified in Fig. 3. Differences in timing of contrast evolution or degree of contrast between the COOH- (zeta potential=−19 mV) and NH2-functionalized particles (zeta potential=−8 mV) were not detected.
A second finding was that while at 1 h post-injection bone marrow was full of MPIOs, there was also widespread dark, punctate contrast throughout the tissue (arrows, Fig. 2b–f). During the next 7 days, the dark, punctate contrast in the tissue lessened almost to control levels (Fig. 3). Previous data on clearance rate for injected MPIOs revealed that MPIOs clear from the circulation within 5 min [3]. This is confirmed by MRI as the bright streak in the center of the femur is a blood vessel visible even at 1 h post-injection because MPIOs have cleared. Thus, these particles are likely trapped within small capillaries in the tissue or within extracellular matrix components.
Toluidine staining (Fig. 4a) on decalcified tissue sections of bone marrow reveals the classical cellular makeup of bone marrow, consisting mainly of small, dark stained monocytes, with some lighter stain granulocytes. Larger megakaryocytes are also present. Figure 4b shows an unstained section where many small, brown particles are dispersed throughout the tissue. Fluorescence microscopic analysis of bone marrow aspirates clearly showed that MPIOs were in the aspirate, but in no instance was an MPIO found within a cell; rather, MPIOs were free floating.
Flow cytometry was performed at 2 and 7 days post-injection. At 2 days post-injection, flow cytometry for CD11b (Fig. 5a), a marker for monocytes, and CD45 (Fig. 5b), a marker for cells of the hematopoietic lineage, consistently demonstrated that >95% of bone marrow cells were CD45+ and that ~70% were CD11b+. However, flow cytometry detected barely any double positive cells (<0.5%), that is, virtually no bone marrow cells contained MPIOs (Fig. 4). This was also the case at 7 days post-injection (Fig. 5c).
Monocytes and macrophages can be labeled in cell culture with large amounts of magnetic material using either (U) SPIO or MPIO, enough to enable single cell detection in vivo. Due to the long half-life of USPIO in the blood (25–30 h), USPIO have the potential to interact long enough with monocytes in blood or marrow in vivo to enable endocytosis. However, the amount of labeling of monocytes in vivo is much lower than that achieved in vitro, and may preclude robust in vivo single-cell detection. Because MPIOs pack enough iron per particle such that one or a few particles are needed for detection [8], MPIOs are an attractive alternative for in vivo labeling of monocytes for subsequent single-cell detection. However, as opposed to USPIO which have a long blood half-life, MPIOs are cleared from blood within minutes [3], thus leaving endocytosis by monocytes in the marrow as a reasonable hypothesis.
This work shows that indeed, MPIOs rapidly arrive in large quantities in bone marrow following systemic delivery. However, following both microscopic and flow cytometric analysis of bone marrow cells, it was determined that MPIOs were not inside CD11b+ monocytes, nor CD45+ cells of hematopoietic origin. This was the case for all MPIO formulations. As expected, MPIOs were also present in large quantities in the liver, spleen, and kidneys and remained there for the entire 7 days of the studies.
These results are challenging to interpret in light of recent reports on the successful use of MPIOs to prelabel monocytes for MRI-based cell tracking of inflammatory response. For example, Yang et al. delivered MPIOs in much smaller dose to mice 7 days prior to myocardial infarction (MI) and observed a substantial number of iron-laden macrophages in the infarct starting at 3 days post-MI [3]. Similarly, Ye et al. delivered MPIOs 1 day prior to cardiac transplant and detected iron-laden macrophages within rejected organs at 1 week post-transplant [14]. However, neither of these papers investigated when or where the macrophages acquired the label.
The data presented in this work and others suggests three possible hypotheses for MPIO labeling of monocytes. The first hypothesis is that, indeed, monocytes can be labeled directly in bone marrow with MPIOs, but that it requires depletion of the circulating monocyte population by administration of clodronate. Tacke et al. used this approach to label marrow resident monocytes [12]. Activation of the immune system may also be required, resultant from injury or disease, as was the case for Yang et al. [3] and Ye et al. [14].
The second hypothesis is that the majority of MPIO labeling of monocyte occurs in the spleen. This is supported by histology showing widespread distribution of MPIOs in the spleen as long as 7 days post-injection. Indeed, the spleen is a reservoir for monocytes. Wu et al. show convincing evidence that intravenous delivery of USPIO/protamine sulfate complex efficiently labels splenocytes [15].
The third hypothesis is that macrophages which have already responded to the insult endocytose MPIOs from the circulation. This is supported by the observation that, despite extremely fast clearance of MPIOs from the circulation (half-life <5 min) [3], MPIOs continue to accumulate in bone marrow for several days following the injection. This occurs with a concomitant clearance of MPIOs from vessels in the muscle. Thus, there is a slower clearance of MPIOs from the total vasculature and is likely undetectable by the methods previously used to measure clearance rate, i.e., fluorescence signal in blood, or MRI of the blood itself.
A final point is the consequences of the hypotheses drawn above, or more directly, why is it important to determine the mechanism of in vivo magnetic cell labeling of monocytes. A major reason is that if we understand the mechanism, we can devise methodologies for enhancing labeling. A key to lowering detection thresholds for labeled cells is to boost the amount of magnetic material within labeled cells. Strategies have been developed which either functionalize the surface of particles to make them more attractive for monocyte endocytosis [16] or as in the work discussed in this paper, the use of MPIOs. If the marrow presents a physiological or physical barrier to particle labeling, and most magnetic labeling occurs in the spleen, clinical approaches to monocyte tracking are likely to be altered. For example, since MPIOs can label monocytes in whole blood within a 3-h incubation period, perhaps a better mechanism for clinical implementation of MPIO-labeled monocytes is to draw blood, incubate with MPIOs, then reinject the labeled blood back to the patient. Or, as demonstrated by Tacke et al. [12], if it is neutrophils which can endocytose large particles and deliver them to marrow-resident monocytes, then neutrophil targeting might be preferable for in vivo labeling.
MPIOs may have beneficial uses for MRI-based cell tracking of immune cell infiltration into injury or disease. Systemic administration of various MPIO formulations showed that MPIOs arrive in bone marrow rapidly following injection and remain there for at least 7 days. Data also show slow clearance of some particles from the tissue over this period. While MPIOs can efficiently label monocytes in culture and in whole blood ex vivo, they were not found to label bone marrow-resident monocytes. These results were obtained in animals in the absence of injury or disease.
Dr. Mark Horowitz, Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, is acknowledged for teaching us many of the biological procedures described herein, as well as for allowing us to perform the bone sectioning and histology in his laboratory. Dr. Menachem Elimelech, Chemical Engineering, Yale University, is acknowledged for providing us access to the Zeta PALS system. Dr. Diane Krause, Department of Laboratory Medicine, Yale University School of Medicine, is thanked for providing us access to a cytospin. Support received by National Institutes of Health grants DP2 OD004362, P30 NS052519, and P30 DK072442, and the Dana Foundation.
Conflict of Interest. The authors declare that they have no conflict of interest.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text: Good afternoon to you all, Just messaging to say hello, my name is Slug and along with my submissive E, we are a 24/7 D/s male led relationship. Probably not what most would be expecting as no cuckolding going on here. Experienced in Impact play, medical play, long term bondage, We joined here because the submissive gets off on being in servitude and pleasing me and well, this gave me the opportunity to indulge in wanting her to please me even further, if you get what I mean. Very welcoming and happy to respond to messages and make friends within this community.. And by the way, my Avatar is my submissive

subset: commoncrawl


text:
High School Teen's Prom-Posal Gets Rejected In The Worst Way [Video]
This kid is never going to go to school again.
This kid is never going to go to school again.
Prom season is supposed to be an amazing, once in a lifetime night for high school students, but in Saginaw things took a deadly turn after numerous girls were shot at a pre-prom gathering.
We're in full blown prom season and this can be an exciting time or embarrassing for high school students. Time magazine revealed the prom picture of President Barack Obama and they look to be embarrassing but who really know what fashion was like in the '70s?
Over the weekend teens from Grand Blanc High School attended prom. Several of the Grand Blanc Students were kicked out of prom after 'inappropriate dancing.' There has been a dancing ban in place by school officials to prevent outrageous dance moves but things escalated to the point that about 30 students were asked the leave.
A teenager from Northern Michigan made her prom dress out of Starburst wrappers.
She came up with the idea when she saw a friend folding candy wrappers. It took about 18,000 Starburst wrappers to make the corset of her dress, as well as matching hair bands and a purse.
Fifteen males and two females went to a dock on Corey Lake in Michigan last Saturday to take pictures before their prom. As they were saying "cheese" the dock collapsed, sending the teenagers into the water.
Prom season is here and unless you have been planning ahead, be prepared to take a big chunk out of your wallet.
The average price of prom is going up, and it shouldn't be any surprise that the parents are the ones paying for most of it.


text:
Fresco, essiccato, polvere, olio piccante, confetture
Elenco aggiornato Read More ›
I am a Computer Engineer, and a postdoc at University of Bologna. I got my PhD, my master and my bachelor at the same university, but I traveled quite a lot in the meanwile: I had been spending three months at the Florida Institute of Technology in Melbourne (FL, USA) while studying for my master, three months at the Johannes Kepler Universität in Linz (Austria), and finally three months at Raytheon BBN Technologies, which included a few weeks of work at the University of Iowa.
My current goal is to become a valuable member of the scientific community.
I like to read, experiment and create during my free time, and that's also why I want a place where to store my thoughts: there is a small but not-zero probability that they could be of use to someone else, or more probably to me in a while, when I'll need to remember why some stuff was done like it is.
Depending on the target of my posts, they might be written in English or Italian. Consider this a bilingual blog.


text:
March 10 (Reuters) - Private equity group Permira is looking to float Japanese agricultural chemicals company Arysta LifeScience on the New York Stock Exchange, the Financial Times reported quoting people familiar with the situation.
While a sale to a trade buyer is also a possibility, London-based Permira is in talks with banks to discuss an IPO, valuing Arysta at $4 billion including debt, the newspaper said.
Permira bought Arysta, which manufactures insecticides and veterinary medicines, in 2008 for 1.95 billion euros ($1.32 billion).
Arysta is considering whether to move its domicile from Japan to the United States or a country with lower corporate tax rates, people familiar with the matter were quoted as saying by the FT.
A sale is expected to attract institutional investors and trade buyers including China's Sinochem and Nufarm of Australia.


text:
In the late 50's and continuing into the 70's television experienced a boom in popularity due to the lowered cost of owning a set. The dominating genre on TV at this time was the western. At one point as many as 26 individual shows were classified as westerns. This saturation eventually killed the market and shows were cancelled left and right. The variations of the genre continue to this day and westerns have been resurrected on the big screen winning an Oscar along the way.
SuperHero films like other genres before have been in and out of vogue, especially over the last 20 years or so. It stands to reason that at some point in the not too distant future we will see a time where there won't be 3 or 4 feature films released in a year and also have competing shows on TV networks. We are most likely in the midst of the golden age of superhero films!
Time will have to pass before we can truly assess the quality and impact of the current state of films. In the future fans may find themselves yearning for a film featuring any hero regardless of how many villains he fights, whether or not he/she wears the comics accurate costume or follows the origin/story faithfully. So try to enjoy it while it lasts and not be too nitpicky over choices studios and directors make, if you were given the chance to make such a film your choices may not please everyone either.


text:
Great for any kitchen setting, great to have "on hand" for heated situations. This potholder is made from 100% cotton canvas fabric and contains a terry cloth liner construction, as well as a silver colored heat-resistant backside for added safety measures.
This product hasn't received any reviews yet. Be the first to review this product!


text:
More from nothing.
The amount of coconut water found in a coconut will yield about a glass if you're lucky, and most likely a little bit less than that.
Nonetheless, the nutrient content is such that the water alone can sustain a human life.
You might not realize it when drinking and you might be a bit dismayed that there were so few sips. It's later, when you start to feel the effects of the subtlety of this sublime creation of Nature that you realize how powerful such a small thing can be.
More from more leads to madness.
More from less leads to peace.
(And, ultimately, you find more from nothing.)
Receive value from this blog? Please consider paying-it-forward by assisting with this service project in Nairobi, Kenya.


text:
If there is one item guaranteed to be on every fast food breakfast menu it would be hashbrowns, and I'm sure everyone has a preference, So I'm curious, what's yours?
Mines leans towards to often ordered McD's, albeit at times I find it way too greasy. I prefer when it comes out crisper and not limp like it has on occasion. Burger King I have never been a fan of. I don't know if it's the oil the use, but for some reason theirs has always left me feeling kinda ill.


text:
A Régence Style mirror, carved gilded wood with a dark green painted background and a flower basket crest. Circa 1860 -1880 46.5"H x 29.5"W x 1.5"D As always, more photos available upon request. We have a large selection of French antiques. Please visit our web site.
6 other shoppers have this item in their Cart or Wish List .
French and Continental Antiques from the last three centuries
Celebrating 31 years in the Antiques Business


text:
There are 8 other file types using
the P file extension!
.p - PDB chemical modeller output file
.p - AKAI audio file
.p - MATLAB binary-runtime P-file
.p - Progress Database procedure file
.p - ReaGeniX code generator application parameter file
.p - ZX81 picture image
.p - Python module
.p - Creamware Pulsar audio
P file extension - Pascal language source code file
What is p file? How to open p files?
File type specification:
The P file extension is associated with the Pascal an influential imperative and procedural programming language, developed in 1970 by Niklaus Wirth as a small and efficient language intended to encourage good programming practices using so-called structured programming and data structuring.
The .p file stores Pascal language source code.
Mime: text/x-pascal
The default software associated to p file type:
Company or developer:
Embarcadero Technologies, Inc.
Turbo Pascal is a software development system that includes a compiler and an integrated development environment (IDE) for the Pascal programming language running on CP/M, CP/M-86, and DOS, developed by Borland,
List of software applications associated to the .p file extension
Recommended software programs are sorted by OS platform (Windows, macOS, Linux etc.) and possible program actions
that can be done with the file: like open p file, edit p file, convert p file, view p file, play p file etc. (if exist software for corresponding action in File-Extensions.org's database).
Click on the tab below to simply browse between the application actions, to quickly get a list of recommended software, which is ableto perform the specified software action, such as opening, editing or converting p files.
- Open p file
- Edit p file
- Create p file
- Others p file
Software that open p file - Pascal language source code file
Click on the link to get more information about Turbo Pascal for open p file action.


text:
Obituary: Pratt, Douglas Brian
Sun., April 22, 2012
Douglas Brian
Doug was born on his dad's birthday on September 9, 1959 on the family farm at Rockford, Washington.
He was born in the same house in which his dad and his grandfather had been born.
He loved everything about the farm, and was doing what he loved on the day a heart attack ended his life.
Doug moved with his family from Rockford to a farm near Tekoa, WA when he was in the fourth grade.
He loved sports, Boy Scouts, and his many friends.
He attended college at Washington State University for two years and then returned to the farm at Rockford where he was born.
His brother David, who was two years older than Doug, preceded him in death in 1971.
He leaves this three beautiful daughters - Jami who is 15, Marley who is 13 and Staci, who is 10, and their mother Denise.
His mother and dad, Milton and Shirley Pratt of Rockford, also survive him, as do his brother Rick (Diane) and family of Richland, and his sister, Diane (Dennis) Solbrack and family of Colfax.
The families include his seven nephews and nieces.
Memorial contributions may be made to the Fairview Cemetery in Rockford in his memory.
A memorial service will be held at 2:00 p.m. on Sunday, April 22 at the Rockford United Methodist Church.
Interment will follow at Fairview Cemetery in Rockford.


text:
Finca for sale in Estepona Alta, Estepona
Built 85m² • 2 Beds • 1 Baths • Terraces N/A • Plot 8400m² • reference: R2553740Enquire about this property
Energy Efficiency CertificateView EEC for this property
Property Description
Finca-cortijo Andalusian style total area including house is approx 8400 m². ,2 beds, 1 baths.. THE PROPERTY: Andalusian style house, there are two large bedrooms, 1 bathroom and living room with fire place. The House has a total area of 8400 m2, there is an ideal space to build a swimming pool and separate garden with all kinds of fruit and vegetables. for lovers of horses website to have more than one with its blocks. LOCATION: The House is located in El Padrón (Estepona) only 5 min. driving from the main road leading to Marbella (Puerto banus). A perfect place to enjoy the tranquility of living in the countryside but at the same time close to everything. DISTANCES: Puerto banús: 20 min. Marbella: 25 min. Málaga airport: 60 min. Beach: 8 min. (by car) SUMMARY: Finca - Cortijo in San Pedro Alcántara, Marbella, Málaga built 8400 m2, 2 beds, 1 baths.
Want to know more about this Finca? Ask Elena:
Elena Amez
VIVA Customer Services
More properties from the search results:
« Back to my property search results
See all properties in Estepona / See all the fincas in Estepona
BenalmádenaMore [+]
La Cala de MijasMore [+]
ElviriaMore [+]
MarbellaMore [+]
Mijas CostaMore [+]
EsteponaMore [+]
Puerto BanúsMore [+]
FuengirolaMore [+]
SotograndeMore [+]
CalahondaMore [+]
BenahavísMore [+]
TorremolinosMore [+]
CabopinoMore [+]
ManilvaMore [+]
MálagaMore [+]
We're here to help you
If you've decided to buy a home on the Costa del Sol, but you're not quite sure where, our brief and independently written area guides are a great place to start. But between us we know the region inside out, so whatever you'd like to know, just ask. It's what we're here for!
The VIVA team speak all major European languages


text:
Highland Park
This state-of-the-art facility includes orthopedic physicians, physical therapy and occupational therapy as well as sports performance specialists and wellness services including massage therapy, Mighty Body Band®, and Pilates as part of the Health Performance Institute.
Available Services
Our Team
Hours of Operation
• Monday: 7:00am to 8:00pm
• Tuesday: 7:00am to 8:00pm
• Wednesday: 7:00am to 8:00pm
• Thursday: 7:00am to 8:00pm
• Friday: 7:00am to 5:00pm
• Saturday: 8:00am to 1:00pm
Contact Us
Phone: (224) 765-5550
Fax: (224) 765-5551
We'd love to hear from you! Click here to send us a message.
The Highland Park Rehab office is located just off Highway 41 at Park Avenue West.
1919 Skokie Valley Road
Highland Park, IL 60035
Highland Park Patient Feedback
- All the therapists that I worked with were very helpful and listened to me explain about the pain I had in my back. . I have enjoyed coming here and if I need therapy again I will come here.
- Therapist spent valuable time to explain all medical issues with my knee. Exercise regime he gave me was excellent. Therapist appeared to have genuine concern about all aspects of my recovery. Very pleased overall.
- verall, everyone was so helpful and really wanted me to get better and they gave me such good exercise to do at physical therapy and at home which is helping me become stronger. Everyone was so positive and helpful and I am so great full for getting help here.


text:
For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome
Synthetic peptide:
CQHSYSSPVDNTPSHQ, corresponding to amino acids 2488-2502 of Notch1 intracellular domain.
Our Abpromise guarantee covers the use of ab8387 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"


text:
TV newsreader becomes Britain's first transgender on-screen journalist
A TV news reporter returned to work as a woman yesterday after sex swap surgery.
Jonathan Willoughby presented regional news for ITV for a decade before quitting five years ago after realising he was "born into the wrong body".
He underwent a £14,000 gender reassignment operation and has now returned to Tyne Tees news team as female reporter India Willoughby.
The 50-year-old is Britain's only transgender on-screen journalist.
"ITV have been fantastic"India Willoughby
Yesterday she said: "ITV have been fantastic.
"It hasn't been weird or awkward and they have just welcomed me back."
She added: "I didn't feel nervous at all when I walked back through the door again. They made me feel like I was home.
"I am just getting my toes back into the water for now.
"I have a lot to catch up on from over the last 10 years and all of the technology has changed massively.
"There are obviously a lot of new faces but I can still have the same banter with the old ones.
"They have realised that I am the still the same person."
India was married and has a son aged 17.
An ITV spokesman said: "We're pleased to have India working with us as a freelancer.''


text:
Hausfeld has reached a settlement with three individuals who sought to strike out the UK portion of a settlement reached in the US courts.
In February 2008 Hausfeld's legacy firm, Cohen Milstein Hausfeld & Co, reached a settlement in a US price-fixing class action brought against British Airways and Virgin Atlantic (TheLawyer.com, 15 February 2008).
The £100m settlement gave eight million customers the right to claim compensation. Of that £100m, £73.5m was allocated for paying claims brought by those
who bought tickets for a transatlantic flight in sterling.
The three individuals challenged the ruling on the basis that the US courts should not have taken jurisdiction over UK claims. If successful it would have prevented UK citizens from gaining compensation from the US court.
Hausfeld worked with San Francisco firm Cotchett Pitre & McCarthy to reach the settlement.


text:
|Page (1) of 1 - 11/18/04
|email article
|print page
VFGadgets Intros Series of Heavy Duty Camera HandlesFor the Sony F900, PDW530 XDCAM and Panasonic VariCam Cameras (November 18, 2004)
VFGadgets Heavy Duty Handle for the Sony PDW530 XDCAM
All the heavy duty handles are constructed from 7075 grade hard anodized aluminum weighing in at only 32oz each. Each is designed to be completely electronics ready. The PCI series of handles offer more cooling vents (with filters behind each vent) than the original camera handles. They all have plenty of 3/8" & 1/4" threads on the top for various mounting needs. The flat top of the handles are parallel to the camera lens for direct mounting of a Steady Cam for low angle set up's - no cage is required. Another use is to mount the camera to a fluid head that is upside down on a mini jib for those low angle shots as well. How tough are these handles? They have a lifetime guarantee against breakage and/or stripping of the thread mounts.
The heavy duty handle for the Sony XDCAM offers a heat sink built into the back of the handle for even better cooling. The Assign Switches - (that were on the top of the original XDCAM handle) have been placed on the base of the new heavy duty handle, in the front, for better protection - eliminating accidental use.
The new F900 heavy duty handle is recommended by Accuscene as sturdy enough for their VF120S HD color viewfinder.
These heavy duty handles offer higher levels of protection and new versatility of use for the Sony F900, XDCAM and Panasonic VariCam Cameras.
About VFGadgets
VFGadgets Inc is a Canadian based sales and distribution company dedicated to the introduction of tried and true innovations in production equipment and technologies, developed globally, for the video and film industry
For more information please visit www.vfgadgets.com.
Page: 1
Related Keywords:VFGadgets, Camera Handles, Sony F900, PDW530 XDCAM, Panasonic, VariCam, Sony, Precision Camera, HDW-750, PCI Viewfinder Extension Arm System, Steady Cam, Accuscene, VF120S HD,


text:
Results 1 to 1 of 1
06-23-12, 05:29 #1Registered User
- Join Date
- Jun 2007
- Location
- Maitland NSW,Australia
- Posts
- 401
Unanswered: Print Preview in 2010 Runtime 64 bit
I am using a 2003 database and 2010 Runtime 64 bit. The problem that I am having is when I execute the following code :-
Private Sub Preview_Click()
On Error GoTo Err_Preview_Click
Dim strDocName As String
Select Case display_order
Case 1 ' by date
strDocName = "rpt_comments_all"
DoCmd.OpenReport strDocName, acViewPreview
Case 3 ' by Summary
strDocName = "rpt_comments"
DoCmd.OpenReport strDocName, acViewPreview
Case Else ' date order
MsgBox ("Not a valid selection")
End Select
Exit Sub
If Err = ConErrRptCanceled Then
Resume Exit_Preview_Click
MsgBox Err.Description
Resume Exit_Preview_Click
End If
The default ribbon associated with Runtime displays the Close Print Preview Button (as active), OK so far.
Now when I open in the Print Preview mode the same report or another report using the same DoCmd format as above is displayed as inactive (greyed out).
Is there a solution to this problem without creating a custom ribbon?Poppa Smurf


text:
In response to the Syrian government's war on its own people, the United Nations sent in its crack diplomatic corps last February, armed with short-range shoulder-fired gobbledygook.
Amazingly, the high-minded gibberish of special envoy Kofi Annan's six-point "peace plan" proved completely useless – and was even weaponized by the Syrian government, which has used the peace plan as cover to continue its brazen fratricide for all the world to see.
Two major problems with Kofi's Cure-All:
First, his six points essentially asked Syrian President Bashar Assad to simply become a different person.
All Assad had to do, in Kofi's mind, was to commit to stop the fighting he started; commit to "an inclusive Syrian-led political process to address the legitimate aspirations and concerns of the Syrian people," which neither he nor his father before him has ever done; "ensure timely provision of humanitarian assistance to all areas affected by the fighting" – in other words, for Assad to begin to care about the people he's been waging war on; and release "arbitrarily detained persons, including especially vulnerable categories of persons, and persons involved in peaceful political activities" – in other words, be a totally different type of ruler.
Oh, and "ensure freedom of movement throughout the country for journalists" and "respect freedom of association and the right to demonstrate peacefully as legally guaranteed."
In short, Kofi told Assad, "Just stop being evil!" That's not a peace plan. That's a Disney script!
The other problem with his cure-all is that it was packaged as a peace plan to begin with. It aimed for a cease-fire, with the hope that that would somehow fundamentally change Assad and his goons.
Peace is not the absence of hostilities. Peace is inseparable from freedom and dignity and respect and the rule of law. You cannot achieve those things merely with the laying down of weapons – particularly if it is only one side laying them down.
On the other hand, sometimes – paradoxically – you can achieve those things, the precursors to peace, by taking up arms. The planet is riddled with examples of peoples who had to first fight for their freedom. Do you suppose that lasting, true peace is available to those under the tyrant's thumb?
It's sad to say, sadder to see – but the violence in Syria may just have to play itself out. The Syrians want to be free. Their government won't let them get there peacefully. What choice do they have but to stand up to a menace that calls itself their leader?
Ironically, peace might have been possible if the U.N. had sent aid in to the Syrian people rather than the gobbledygook of diplomats – if the Arab League and the rest of the world had stood with the Syrian people and used the weight of a verifiably united globe to loosen Assad's iron fist from the Syrian people's throats.
Instead, the world stands by and watches as the Syrians cry out for help and for freedom. And the diplomats wonder why. Why didn't our sweetly-written fairytale work?
As one news report put it Friday, Kofi Annan had to acknowledge that, quoting Kofi himself, "Syria was headed down a path of 'brutal repression, massacres, sectarian violence and even all-out civil war'."
Really? It's only headed down that path? Isn't that path already well-trod and littered with bodies?
The Los Angeles Times noted, "Annan urged world leaders to make it clear that failing to comply with the plan would carry unspecified
consequences ..."
Look out! Unspecified consequences are raining down on us!
That'll sure scare the heck out of them in Damascus.


text:
Turkish President Abdullah Gul claimed, "Israel cannot afford to be perceived as an apartheid island surrounded by an Arab sea of anger and hostility," in an op-ed he wrote for the New York Times.
In the article he said that "a dignified and viable Palestine, living side by side with Israel, will not diminish the security of Israel, but fortify it." Gul added that Turkey is ready to use its "full capacity to facilitate constructive negotiations." (Ynet)


text:
If an item you ordered from TextbookRush does not meet your expectations due to an error on our part, simply fill out a return request and then return it by mail within 30 days of ordering it for a full refund of item cost.
Learn more about our returns policy
Limited time offer:
Get the first one free! (?)
All the information you need in one place! Each Study Brief is a summary of one specific subject; facts, figures, and explanations to help you learn faster.
List price: $120.70Edition: 2ndCopyright year: 2010Publisher: W. W. Norton & Company, IncorporatedPublication date: 12/15/2010Binding: PaperbackPages: 816Size: 8.60" wide x 10.90" long x 1.10" tall Language: English
William T. Bianco is professor of political science at Indiana University, Bloomington. His research focuses on congressional institutions, representation, and international cooperation in crewed spaceflight. He received his undergraduate degree from SUNY Stony Brook and his MA and Ph.D. from the University of Rochester. He is the author of Trust: Representatives and Constituents and numerous journal articles. His research and graduate students have received funding from the National Science Foundation and the National Council for Eurasian and Eastern European Research. He has served as a consultant to various candidates, political parties, and government agencies. He was also a Fulbright Senior Scholar in Moscow, Russia, during 2011-12.
David T. Canon is professor of political science at the University of Wisconsinndash;Madison. His teaching and research interests focus on American political institutions, especially Congress, and racial representation. He is the author of Actors, Athletes, and Astronauts: Political Amateurs in the United States Congress; Race, Redistricting, and Representation: The Unintended Consequences of Black Majority Districts (winner of the Richard F. Fenno Prize); The Dysfunctional Congress? (with Kenneth Mayer); and various articles and book chapters. He recently finished a term as the Congress editor of Legislative Studies Quarterly. He is an AP consultant and has taught in the University of Wisconsin AP Summer Institute for U.S. Government and Politics since 1997. Professor Canon is the recipient of a University of Wisconsin chancellor's distinguished teaching award.
*A minimum purchase of $35 is required. Shipping is provided via FedEx SmartPost®
and FedEx Express Saver®. Average delivery time is 1 – 5 business days, but
is not guaranteed in that timeframe. Also allow 1 - 2 days for processing. Free shipping is eligible only in the continental United States and excludes
Hawaii, Alaska and Puerto Rico. FedEx service marks used by permission."Marketplace"
orders are not eligible for free or discounted shipping.
Learn more about the TextbookRush


text:
The Le Canada Hotel is ideally located just a few meters from the sea in the suburb of Hermanville. It is very close to the most historical places such as the Normandy landing beaches Sword, Juno Beaches and the Ouistreham's marina. The hotel offers 18 spacious and comfortable rooms that are elegantly decorated and come with a host of modern amenities. The hotel offers a snack bar which is an ideal place to relax with some drinks and light snacks. A variety of restaurants are also available in proximity from the hotel.
183 Avenue De L'Amiral WietzelCP:FR-14880,Caen,Francia
Teléfono:No especificadoFax:0033222442348


text:
Have you ever had the difficulty to play games after installing Linux? Trying to find lapses in security and messing up the whole interface. Ever tried coding in a basic Linux-based operating system and failed? There is a solution for all these problems all you need to do is to research well online and to have the patience to study it.
Over the years, networking had grown in a manifold proportion and also have the risks accompanied with them. Let's try taking a new perspective in finding out how to avoid these security lapses for your system.
The most sought after solution for protection against security threats is installing an antivirus and web shield. These methods are conventional and so has lots of open windows for hackers to seep through. With widespread advancements in server technology and speed, it's even more difficult for these predefined antivirus software to defend in full capacity. Pen testing and WAP development can only find solutions for existing security risks only, the world of networking is ever expanding with more and more people trying to get information from one another.
To secure your system from the impending dangers of network phishing and malware attacks you should keep in mind certain things:
#1. Try considering your system as a living organism, understand that anything vulnerable to human beings in the biotic atmosphere acts in the same way in the networking atmosphere. So whenever your computer starts heating up it has a fever and hence you can understand that the immunity that is the antivirus is struggling to fight something, and, of course, you should be there as a doctor to provide enough supplementing medication to cure the illness. By doing enough online research and consulting experts to analyze what is wrong with your system, without performing a surgery that is formatting the whole hard drive.
#2. Or let's take a scenario where in your system is taking a lot of time to wake up from sleep, if this happens regularly to a person you will naturally understand there is something wrong with his lifestyle that is slowing him down. Same as that you should also check your systems start up functions and what all luxury bad apps are there which is slowing it down. In such a way, you can understand that computer security is as much as important as protecting yourself from diseases.
Recently Linux-based operating systems are deemed to be very effective against viruses and malware, one reason for this is that most of the hackers choose easy targets, most of whom uses Microsoft or Apple based operating systems. Therefore, the viruses are written in a way it can access the files in a windows or apple system this is where Linux holds an upper hand. And that is the most key point in security based software need to take care of that the idea of OS based attacks can only be defended using redefined tactics. Good luck.
This is a guest post by Vaishnavi Agrawal. Vaishnavi loves pursuing excellence through writing and has a passion for technology. She has successfully managed and run personal technology magazines and websites. She currently writes for intellipaat, a global training company that provides e-learning and professional certification training.
The courses offered by Intellipaat address the unique needs of working professionals. She is based out of Bangalore and has an experience of 5 years in the field of content writing and blogging. Her work has been published on various sites related to Hadoop, Big Data, Business Intelligence, Cloud Computing, IT, SAP, Project Management and more.


text:
+ Elephant Camp and Elephant Trekking
+ Jungle Walk
+ Bamboo Rafting
+ Waterfall Swimming
+ Hill Tribes Village
By the Thailand Northern area still is the completed nature area. (Mountain, Thick Forest, Water fall, River and wildlife can be seen as easily.) Safari Trekking Adventure Tour Package of Jc.Tour can make you touch with the said purity nature.
Before submit the booking, please see the below highlight pictures and study the programs:
Walk through the Thick Safari pass the purity natures, tree, cannel, animal etc.
Continue with sigh seeing the beautiful view of river side by Bamboo Rafting.
Elephant Trekking in the Northern Forest of Thailand get the feeling of real trek
The Local People, real owner of the land plot in the history. Hill TribesVillage.
Enjoy and relaxing at the Water Fall
Real Fun with White Water Rafting


text:
"We actually had a team meeting at one point (during that stretch). We talked about what we needed to do as a team to get it together. After that team meeting, we got back on the same page and went from there."
Related quotes
"It takes more than talking points and consultative knowhow. What sets apart a legitimate and competent advisor from an everyday business consultant is his ability to not only provide recommendations, but indeed stand behind them, and endeavor to personally implement them."
"This is just one of many good stretches for me. Coach told me to set the tone for the team. I think Jeremy (Stewart) and Cortez (Burnett) have done a good job of setting me up with good shots."
"It's not a stretch we're happy with. But we've been in one of those stretches where it seems a lot of bad things happen, when they all come back to bite you in the butt — hard."
"They kept coming back. In one 20 second stretch I think it went from a very comfortable 16 point lead to nine, but overall Peabody couldn't keep up the pace."


text:
Stage Participants Info...
Please use the Forms & Contacts below and join us in creating a great 2017 Bread & Honey Festival !
|The Main Stage
|All performers have been selected and the schedule posted for this year's festival. No further applications will be accepted. To apply for next year's festival, please wait until January 2018 and then submit the online application from this website.
|Upper Lot 'Entertainment Square' Organizer
A note to previous dance troupes and other interested dancers, singers, dramatists
The upper lot this year will have the same type of venue as last year.
The stage will be the same 20X20 flat floor at ground level with a tent covering, and be situated in the centre of the parking lot adjacent to the south side of the arena. It will be a 360 degree venue, in other words there is no back or front. There will be a low fast-fence surrounding it, with an opening on each side.
We are limiting the size of the troupes to 20 people. Free wrist bands will be issued to each troupe, up to a maximum of 20. There is no honorarium (same as last year).
Each performance will have a maximum of 30 minutes, there will be 5 slots available for each of Sat and Sun.
Performance can be strictly a performance or they could be a teaching/interactive approach with the audience.
There will be a small PA system for announcing and a CD player and a technician. For musicians, there will be a technician on site to give you some sound, but that will be limited. Bringing in a lot of equipment will be very difficult because your vehicles will not be permitted on the grounds. If you need equipment then contact me to make alternate plans.
There will be a dressing room available for the performers. If your group fits and/or can adjust to these new parameters, please fill out the online application form below, or the pdf form and email it back to email@example.com .
|New! Apply Online:
|Download Application:
|Island Children's Stage
PLEASE: No Dogs, Bicycles, Rollerblades, Scooters or Skateboards in the Park.


text:
Template >> Business Card - Artistic Design Business Card Bundle 184848 by Sherman Jackson @ CreativeMarket
File Size: 29.29 MB; Requirements: Adobe CS3+; Layered: Yes; DPI: 300 DPI; Dimensions: 3.5 x 2 in.
Presenting to you the Artistic Design Business Card Bundle. 2 stunning business cards to propel your business to the next level.
What's in the bundle
- Two Business Card PSD Photoshop Source files (individual business card links below)
- Each business card contains two psd files - Front and Back designs
- All files are print ready with Industry Standard Print Specifications
View Individual Business Cards
- Artistic Business Card V.2: https://creativemarket.com/ShermanJackson/183650-Artistic-Business-Card-V.2
- Artistic Business Card for Designers: https://creativemarket.com/ShermanJackson/61439-Artistic-Business-Card-for-Designers
Keywords: designer business card, artistic, colorful, painterly, impression, art, graphic artist, identity design, graphic design, modern, beautiful, mockup, business card, visiting card template, calling card template.


text: Hi there! I'm a brand new HTC Desire user, and on the advice of some friends I've installed Meridian media player and Audiomanager (among other apps, of course). The problem I have is that the minimum volume for media is still too loud for me while listening to music at work. Is there any way I could say, lower the overall volume of the phone? Or is there another audio management app that could help me? Secondly, what kind of app can people suggest as an equalizer for adjusting bass/treble etc? Many, many thanks in advance!


text:
Midnite Faery
About Me
My gaming alias is Midnite Faery
I am a girl who plays video games and I decided I would write about my gaming experiences! :)
...and of course my life!
Midnite Faery's Photos on Flickr
Midnite Faery's Twitter
- 7/7 ...seven days. Seven black and white photos of your life. No… instagram.com/p/BblPSF4gox0e… 4 days ago
- 6/7 ...seven days. Seven black and white photos of your life. No… instagram.com/p/BbkQ-2mAbqpL… 5 days ago
- 5/7 ...seven days. Seven black and white photos of your life. No… instagram.com/p/BbdsKQ1APGs2… 1 week ago
Blog Stats
- 17,081 hits
Category Archives: About Midnite Faery
If you have subscribed to my blog previously or you want to subscribe, you will need to subscribe again because I have it running through a different program now. go to http://www.midnitefaery.com and fill out the "subscribe now" box on … Continue reading
Today I am the "special guest" for a podcast on http://www.nerdemic.com! I can't wait. I will be talking about my favourite games and any upcoming games that I am looking forward to! Exciting!! I hope you will check out all … Continue reading
I am so blessed to have such a wonderful family and fantastic friends in my life. Thank you to everyone and I hope you all have a very Merry Christmas and Happy Holidays! I will be around for the next … Continue reading
This is the first real Christmas that I am not going to spend with my Dad or brother. Plus, it's the first time knowing that I won't ever see them again during the holidays. But I've decided that life carries … Continue reading
A Year Has Passed I was afraid of yesterday. I didn't know what to expect. I knew December 13th was due to come and I knew I would have to face the anniversary of my Dad's death. I remember every … Continue reading
Ramblings I have been sort of awol from writing in my blog for the past couple weeks. My Gaming & Giving Back Challenge got scattered due to some rather unfortunate situations at work. I can't wait to start participating again … Continue reading
Sharing This morning was rather dreadful outside. The rain was pouring down and it had to be below 0 degrees! I went about my usual morning routines. Got up, got ready for work, and started my trip into work. I … Continue reading


text:
The Netherlands will not deviate from the internationally agreed norm of earmarking 0.7 percent of GDP for development aid.
During the parliamentary debate on his budget for 2012, Deputy Development Aid Minister Ben Knapen said that the CDA Christian democrats / VVD conservatives would not deviate from the international norm for the whole of its term in office.
Opposition parties D66 Democrats and the Green Left Party urged the deputy minister to provide clarity after the Freedom Party, which supports the cabinet in parliament, announced that any additional cuts would have to come out of the development aid budget.
© Radio Netherlands Worldwide
© Radio Netherlands Worldwide


text:
Hi to be a professional Spanish traslator, you have to have a special certificate that allows you and convince all people that you are professional, and that's easy. You will lose nothing, just go and study DELE and then see what will happen after that, you will gain more skills and vocab, also will let people know that you are special and uniqueHow can I become a Spanish Translator?
What is DELE and how do I find more about it???
Report AbuseHow can I become a Spanish Translator?
okay my gf is majoring in spanish, she wants to be a trnslator, and well she is gettign her degree and all that. so if you would like to work for the gov't and all that you most likely need a degree.
however there are some small offices that need translator, for paperwork and clients. it all depends on where you live. but look around a lot of insureance places use those, or just people who would deal with a lot of people or great variety.
good luck!


text:
Build Guide by Yarick
This build has been archived and is for historical display only.
PLEASE NOTE: This build has been archived by the author. They are no longer supporting nor updating this build and it may have become outdated. As such, voting and commenting have been disabled and it no longer appears in regular search results.
Not Updated For Current Season
This guide has not yet been updated for the current season. Please keep this in mind while reading. You can see the most recently updated guides on the browse guides page.
Thank You!
Your votes and comments encourage our guide authors to continue
creating helpful guides for the League of Legends community.
Annie Build
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Introduction (Know Your Role)
Annie is a AP Nuke and she is one of the best currently in the game.
Below is a guide on how i play Annie in 5v5 games which i find to be rather effective.
As always check that your team requires a AP nuke if they already have one then pick another champion there is no point in having several nukes as you will drop a couple of people in team fights and then get aced.
Know Your Role
The AP nuke has 1 main role in a team fight and that is to nuke the opposite AD carry. If you fail to do this and you loose the team fight then its most likely your fault. The more hits the AD carry gets the faster your team will drop and you have the ability to drop them in under a second, so do it.
Pros / Cons
1) one of the best nuke champs in the game
2) can do True damage to AD carrys (see Ability Power vs Magic Penetration)
3) large damage area stun with tibbers can change a team fight
4) strong enough to take several hits from a AD carry
5) punches like a glass cannon but wont shatter like one
1) if you get behind you will need assistance to kill
2) quite slow with average escape mechanism so be map aware and don't go to far solo
Ability Power vs Magic Penetration
My build does not have as much Ability Power as some builds but with the high Magic Pen it will give better nuke results
At level 18, magic resistance ranges from Twitch and Nunu's 30 MR (23% damage reduction), to the 51 MR of Warwick, Evelynn, and several others (34% damage reduction).
Our Runes give us a total of 14.22 Magic Pen
Ashe a typical AD carry has 30 MR as standard
Magic penetration and magic resistance reduction are applied in the following order:
1)Percentage Magic Resistance Reduction
2)Flat Magic Resistance Reduction
3)Flat Magic Penetration
4)Percentage Magic Penetration
so lets do the maths
1) no change
2) no change
4) 15% from Mastery Archaic Knowledge (85% of 15.78 = 13.413 MR)
giving them 11.82% damage reduction instead of the 23% at level 1
you can reduce this further by leading with Exhaust+Cripple for an additional 10 MP leaving them with 3.413 MR which is 3.3% damage reduction so almost True damage from the start.
The build ends with a total of 54.22 MP and 20 Magic Reduction totalling 74.22 Penetration
and a AD carry is only likely to purchase upto 1 MR item which is likely to be Banshee's Veil to try and counter your stun.
so lets do some end game maths on Ashe with Banshee's Veil (30+50 = 80 MR)
1) no change
2) 20 from Abyssal Scepter (80 - 20 = 60 MR)
3) 54.22 from runes, boots and Haunting Guise (60 - 54.22 = 5.78 MR)
4) 15% from Mastery Archaic Knowledge (85% of 5.78 = 4.913 MR)
giving them 4.68% damage reduction instead of the 23%
if once again you lead with Exhaust+Cripple for an additional 10 MP and you do True Damage.
You ability's AP ratio are 60% and tibbers at 70% so to make up for the 18.32% damage you would need more than 18.32% additional Ability power (approximately 25% more AP would be needed to pack a similar punch)
As i will go through in later sections i go with the MP build as it enables you to pack a punch early on as well as build survivability and all quite cheaply whilst a pure AP build tends to leave you very glass cannon like and forces your tank to make tough decisions on if to save you or not (when they should be keeping your AD carry alive).
Summoner Spells
Flash is a life saver and a very good spell on almost any champion, with Annie it works well as it can enable you to flash towards a fleeing enemy to land a spell or as your 2nd choice in escape mechanisms (your stun should be first).
Exhaust same as flash this has offence and defence potential, it can be used as a 3rd choice escape mechanisms (stun flash exhaust) and should get you out of most situations. It also is handy during a nuke when you know you need additional spells after to get the kill a well timed exhaust will keep the enemy in range whilst your spells come off cool down, additionally if you lead your nuke with Exhaust it will reduce there MR by 10.
Marks and Quints of Insight as this is a good way to get a flat boost early on for MP
Seal of Clarity for mana as whilst you should not be using to much mana especially near the start you will still be using some and this should keep you topped up
Glyph of Celerity for cooldown as you need tibbers back as soon as possible after a nuke and during a nuke on tough opponents you may need a 2nd round of disintegrate/incinerate.
Skill Sequence
Disintegrate is your starting spell it will enable you to farm at the start and quickly prep Pyromania with no mana cost if you kill a minion with each shot. It is also the easiest spell to land a stun with as its a guaranteed hit and so it is usually the chosen stun spell to lead a nuke.
Incinerate at level 2 does more damage then Disintegrate so whilst both need to be levelled up quickly you should lead with Incinerate to maximise damage output, unless you are finding you need to do a 2nd disintegrate in the combo then you should lead with that to max damage output.
Molten Shield i get at level 5 as its good for preping your stun and is a handy little deterant for melee champions, after level 5 i leave this skill to last though.
Summon: Tibbers as with most Ults get this when ever possible and use it wisely
Masteries (9 0 21)
The main reason i have gone 9 0 21 is for the additional cool downs on spells and ability's
Cripple will stop people running away or assist you in running away and in the Ability Power vs Magic Penetration section above it would cause you to do true damage to the AD carry if you lead with it.
Archmage's savvy as the additional AP is always nice
Sorcery as the cooldown is helpful
Archaic Knowledge as the penetrate 15% resist is nothing to be sniffed at especially when attacking targets other than the AD carry
After this point the Offence tree does little benifit for Annie and so ive focused on the Utility tree
Perseverance will help out with mana issues and supply a little health
Good Hands as there's nothing else of use
Awareness as being ahead of the carry on levels makes your job much easier
Meditation to help out with mana regen
Greed often branded with being pointless but this little mastery makes it so you can afford to buy a few wards and still keep up with your equipment
Utility Mastery if your really against greed take 2 in this but i find a few wards per game much more useful than 15% more buff as the blue/red buff are often much more useful on other champions
Quickness for survivability
Blink of an eye as its a summoner spell
Intelligence for even more cooldowns
Presence of the master as your summoner spells greatly increase your killing/surviving ability
Starting Items
Sapphire Crystal and 2 Health Potions
With this you should be able to sit in lane at the start for a fair while
First 1-2 trips back
1350-1420 is a fair amount for your first trip back so unless i get a kill or 2 i often take 2 trips
until i finish rod of ages i try to keep 3 health pots on me and i always try keep a mana pot
the Mana potion is hugely important as usually once during a game you will find your self in a spot where you desperately need it so don't be cheep and spend that 40 gold
Core Items
Speed and Magic pen is just what Annie is asking for so get this early and you wont regret it
This is what makes Annie hard to kill whilst still packing a punch, I get Catalyst early to help me stay in lane and then boots to help with positioning before finishing off rod of ages which takes 10 mins to be of full use so you need it quite early on.
Haunting Guise adds to everything you really need AP Health and MP and its cheep so get this as the 3rd of the core items.
End Items
Take the following items in any order checking to see which will best assist you
Your not dieing buy your not doing enough punch? then this is the item for you.
Having trouble with other mages? or your team is magic heavy? then get this item.
Having trouble with Physical champs? or they have karthus? then get this item.
Other Possible Items
It should be taken as a given that all Annie's items should by AP based as your job is to kill with your nuke not tickle them and AP items listed above give some survivability so i will quickly go through the rest of the AP items with my opinions on them for Annie.
(NOTE these opinions are for the items on Annie not on the items in general)
Archangel's Staff
As you don't have mana issues and you don't spam your ability's this item is not the best for you
Deathfire Grasp
Can incorporate into your nuke well if you lead with it but then your not leading with the stun which you really need to be or the AD carry will flee. This item can work well but i prefer to use others
Guinsoo's Rageblade
No as you cannot keep the stacks up and the attack damage is a waste
Hextech Gunblade
attack damage is a waste again and so is the life steal, the spell vamp with have little effect but the active could be handy. all in all not worth the money for annie
Lich Bane
mana is a waste and so is the passive, the speed AP and MR could be nice but not really worth buying it for half an item
this is for magic spammers not you
Mejai's Soulstealer
To Mejai or not to Mejai well that is the question, personally i find Mejai on Annie a little unstable and prefer them on champions further back in the fight. The problem with Annie is to kill the AD carry you need to be quite near the front of the fight which leaves you open for attack and whilst your tough enough to get your nuke off surviving it isn't always possible
Morello's Evil Tome
not a bad little item the mana regen is a little waste but still worth it
Nashor's Tooth
no we don't need attack speed
Rylai's Crystal Scepter
good item to bulk you up and still give AP but the passive is a bit of a waste as most of the time you will be stunning for 1.75 secs which will negate the slow
Trinity Force
the AP and speed would be nice but the rest is pointless and the cost to great
Void Staff
we should already be doing true damage any way making this item not worth it
Will of the Ancients
whilst not a bad item and very handy to have on your team its better suited to a champion that can make use of the spell vamp, if you have fallen behind try get some on to buy this item as the 30 AP will be quite handy for you
The 3 kinds of stun
Annie has 3 ways to stun and all have slightly different uses
Is very good at a single target stun and so is often used when you do your nuke as this will make it so the AD carry cannot flee and so that you can land the rest of your spells.
an area stun that can be harder to pull off due to the close proximity but has the benefits of hitting multiple targets which can be priceless when fleeing from multiple enemies.
the Tibbers stun should be used when you need to nuke the AD carry and other people are standing nearby if placed well this can be a real battle winner as multiple targets will take your nuke (still focus AD carry with Disintegrate)
Remember to prepare your stun as much as possible, you can have stun prepared in 2 ways
1) have Stun as your next spell you will have a swirl around you telling your opponent stay away or your stunned
2) walk around with 4 stacks on and shield ready (this is my fav) people will now never be sure if you have stun or not and you just add shield at the start of your combo to give you move survivability
You really should not be walking around without stun prepared as your just asking to die so keep it preped.
What Lane?
Personally i think Annie is a bottom lane champion and here is why
Why not to Solo Top or Mid
1) lack of regen will cause you to be drinking to many pots
2) no quick ways to get back to lane will loose your team XP
3) hard to get a kill unless they turret dive you
4) whilst you can harass some champs you are not a natural harasser
5) if you are out ranged then your in deep trouble especially if there a natural harasser
Why to Lane with a partner
1) the additional damage they provide will make getting kills much easier
2) assuming you take turns to refresh no XP will be lost
3) you do not need to have your stun up as much depending on your partner
4) last hitting will be easier as your partner can harass whilst you farm
Whilst i believe Annie is best in bottom lane against certain opponents she can do very well in mid its just there's not that many, as a simple rule look at there potential mid chars and think am i out ranged? if the answer is yes try avoid mid.
Bottom lane partners
so your in the bottom lane so who is good to lane with?
well at the bottom lane you will generally be put with a AP support or a tank/offtank and here is why
there are 3 spots that will get champions ahead either via gold and/or XP and these need to be taken by certain champions.
Top and Mid will get the most XP/gold so the AD carry should take one of these, its the junglers job to to try and keep up with with them on XP/gold and will generally be slightly behind depending who there jungling on, the bottom will share XP and so be the lowest but your lane partner should allow you to last hit every minion which will get you as much gold as mid. As Annie inst as level dependant as AD carrys your team will get the most benefit with her at the bottom last hitting all the minions.
Very generally speaking the ranged AD carry normally takes mid as they should be able to easily last hit all minions.
Top lane is usually taken by some one with a bit of regen and toughness as they maybe facing 1 or 2 opponents the additional gold/XP will help with this
you really should have a jungler and these champs tend to be AD and reasonably tough often building into a tank or off tank.
so this leaves you normally with a support or a tank or a off tank, below are the ones i play along side with often and i rate, there are many more combos that would work well basically you need some one who can do a bit of damage and any CC is always handy.
Remember your lane partner will be the worst off on the team as far as gold is concerned and joint worst on levels so it is important you call in the jungler to gank when possible, it is also important to ward dragon between you and assist with killing it if needed. (most jungle routes end at dragon between the 6-7 min mark)
The majority of the champions listed below can also push waves easily which will allow them to catch up on gold once the team fights start.
Rupture and Feral Scream is very handy at saving you/setting up a kill and a well timed Feast will work well with your nuke. Additionally a well timed Feral Scream in team fights will give you more time to nuke and its nice to get into practice doing this during the lane phase.
shield, slow, awesome harasser, loads of damage and a ult to finish the ones that run away, Perfect
a slow, can harass, quite tough and the double nuke should take out most opponents.
damage a massive shield and crowd control to keep the other opponent at bay
traps should help protect from ganks and heals to stay in lane longer and huge harass damage from Javelin Toss
a stable tank that normally packs a punch, Vorpal Blade can help with health regen and he is quite good at keeping you alive
Tibbers is your highly useful pet that you can control by pressing Alt telling him to attack or move, below is a list of things tibbers should be doing for you if you have him out do not waste tibbers casting him for no reason.
1) check bushes
2) tank turrets whilst waiting for minion wave
3) tank turret so you/allies can pass unharmed
4) turret dive
5) initiate the 2nd wave of an attack
6) harass whilst you escape or kill another enemy
7) watch your back when moving (tibbers follows you giving you more time to spot some one attacking from behind)
If tibbers get over a screen away he will teleport back to you so in some cases it may be best to tell tibbers to walk the opposite direction to you so you get him quicker
Annie can quickly push waves of creeps with Incinerate but early game you want to avoid doing this as much as possible instead focus on last hitting and preping your stun with Disintegrate
Last hitting can take a little getting used to as you auto attack has quite a delay on it but with a little practice you should be last hitting every minion
Tips and Tricks
Annie is quite a simple champion really but there are a few small tips and tricks
1) always keep your stun ready
2) when at the shop cycle your stun as it will regen your mana
3) keep a mana pot handy as usually once per game i need it
4) cast Incinerate and Molten Shield on way back to lane to cycle your stun
5) do not go bush diving, if Tibbers is out then send him in
6) when recalling use Tibbers (assuming hes out) to scout nearby places people maybe jumping you from
7) on the loading screen look at the other champions and prioritise your targets for team fights
8) take it easy at the start harass a little if possible and wait for Tibbers ensuring to get the max possible amount of minion kills
9) Molten Shield will cycle your stun but unlike your other spells it doesn't use it up so keep casting it when you have stun ready to give your self more protection during team fights
The Nuke Cycle
For the standard nuke you will start with 4 stacks and this is the state you will be mostly walking around in
4-5) Molten Shield
5-1) Disintegrate
1-2) Incinerate
2-3) Tibbers
3-4) Disintegrate
4-5) Incinerate/Disintegrate
5-1) Incinerate/Disintegrate
as Incinerate has a longer cooldown than Disintegrate i tend to fight with the above combo initially leading with a single target stun on the AD carry and then finishing with a area or single target stun into the team fight as required.
do not be afraid to break from this combo if you get a chance to Tibbers stun more than just the AD carry then do so as this can put your team at a huge advantage.
Expected Damage
Totalling up the items i believe you get 595.8 AP with this build which is all True damage against a AD carry
Disintegrate 260 + 60% AP = 617.48
Incinerate 325 + 60% AP = 682.48
Molten Shield 60 + 20% AP = 179.16 per basic attack on Annie
Summon: Tibbers 450 + 70% AP = 867.06
Tibbers also has 130 attack damage and 80 continual damage
so the standard 3 spell nuke should do 2167.02 True Damage and that's before Tibbers additional 130 and 80
I have mentioned it many many times in the guide but its worth mentioning it again
Your job is to kill the AD carry
once this is done then try save your self and assist in the team fight
Annie's job is quite hard or at least to do it and survive as you need to kill the AD carry near the start of the fight so most people will be alive and the tank will be standing in your way trying to protect the AD carry, and this is why its the Nukes job as they can get in nuke them quick and hopefully get out.
the build i believe gives enough nuke ability whilst providing enough survivability to do this task.
Rod of Ages and Haunting Guise will bulk you up so you can take a few hits
Abyssal Scepter provides MR
Zhonya's Hourglass provides armour and a 2 sec invulnerability giving your team time to roll over
Flash should provide you with a method to hop back into the protection of your team
and Molten Shield will help to keep you kicking that little bit longer
Patch and Updates
Patch (Date d-m-y) - Comment
1.34.12 (29-04-2011) - First Published
1.34.21 (13-05-2011) - Added Tip 9
1.34.21 (15-05-2011) - text change due to Rod of Ages update


text:
Results 1 to 2 of 2
May 4th, 2004, 07:41 AM #1
First commission to BasementHomeTheater has been accrued!
Let's see, 12 days live, $.05 in commission. Retirement is JUSSSST around the corner...
Thanks to everyone in here who has helped, directly or not. I've read and learned much here.Kevin Webster
twitter: levelanalytics
Kayak Fishing
Web Analytics and Affiliate Marketing
May 4th, 2004, 08:18 AM #2
- Join Date
- January 18th, 2005
- Posts
- 247
A nickel a day keeps the...hmmmm, well it's a start
Cheers to you, here's to many multiple times nickels in the months to come.
Similar Threads
First Ebay nickelBy John Kruger in forum Commission Junction - CJReplies: 2Last Post: September 11th, 2003, 05:26 PM
no sales today, not even a nickel.By ToughTurkey in forum Commission Junction - CJReplies: 21Last Post: December 2nd, 2002, 05:40 AM


text:
Q&A Categories
Find a Question:
If you are happy you want to spread happiness.
If you are happy you want to spread happiness. If you are agitated you want to be violent. If you are angry then you want to express that. If you are jealous you want to express that, and if you are happy and in love, you want to spread that. – Sri Sri Ravi ShankarViewing:-239
Tags: sumo-pro-4-3-7
Answer this Question
You must be Logged In to post an Answer.
Not a member yet? Sign Up Now »
Sign Up
Get all of your questions answered now!
Member Log In
Videostreaming is so great, until one reaches the limits of the network and the videos jerky more th...
Star Points Scale
Earn points for Asking and Answering Questions!
[1 - 25 ]
[26 - 50 ]
[51 - 500 ]
[501 - 5000 ]
[5001 - 25000 ]
[25001+ ]


text:
MOVIE SYNOPSIS [ General Audiences ] With an impeccable performance of Solomon Bendjy, this film directed by Young Man Kang was premiered in cinema in 2013. The film "Innocence Abandoned: Street Kids of Haiti" had an original production of USA and Haiti. You can watch Innocence Abandoned: Street Kids of Haiti online on TV cable or theaters with original audio in English at different dates. This film premiered in theaters in 2013.
Rating: 5 by 10 users./
Runtime: 90 minutes
Solomon Bendjy, Michael Brewer, Sandy Cesar, Cynthia Charles, Emmanuel Charles, Mario Charles, Williams Deralien, Christine Diga, Stephen Garrett, Alan Juinille, Young Man Kang, Krik Krak, Dennis James Lee, Tomiko Lee, Maggie and Emerson Tuitt Malcolm.
Documental, Drama, Historic.
90-minute film (full movie) directed by Young Man Kang.
The original audio of Innocence Abandoned: Street Kids of Haiti has dialogues in Dolby Digital, it was produced in USA, Haiti.
It premiered in cinemas or television in 2013.
Screenplay written by Katharine Osborne, Young Man Kang and Dennis James Lee.
Young Man Kang.
Tomiko Lee, Ron Becks and Dennis James Lee.
This film was produced and / or financed by Leap Frog Productions Inc..
Composed by Dennis James Lee and Simeon Spiegel.
Without commercial breaks, the full movie Innocence Abandoned: Street Kids of Haiti has a duration of 90 minutes; the official trailer can be watched in streaming on the Internet. You can watch this full movie free in EnglishDolby Digital in movie TV channels, renting the DVD or with VoD services (Video On Demand player, Hulu) and PPV (Pay Per View, Netflix).
See the page of this full movie, Innocence Abandoned: Street Kids of Haiti in FULLTV Movies.


text:
Abbas calls for Hamas overthrow
Fri., Nov. 16, 2007
Palestinian Authority President Mahmoud Abbas sharpened the war of words against his Hamas rivals Thursday, saying it was time to "bring down" the militant group's regime in the Gaza Strip.
Abbas' comments against Hamas, whose fighters defeated his Fatah faction to take control of Gaza five months ago, reflected his anger over a deadly clash in the coastal enclave earlier this week.
"We have to bring down this bunch which took over the Gaza Strip by force and which is trading on the suffering and misery of our people," Abbas said in broadcast remarks marking the 19th anniversary of the Palestinian declaration of independence. He referred to Hamas, with which he formed a short-lived joint government earlier this year, as "outlaw gangs."
Abbas previously has used harsh language to attack the radical Islamist movement, characterizing its leaders as coup plotters and demanding they give up their control over Gaza. But his latest remarks struck a more combative tone.
Sarkozy says he'll talk with strikers
France's transport strike eased but did not end Thursday, after President Nicolas Sarkozy accepted negotiations while refusing to budge on his campaign promise that cushy retirement benefits must go.
Frustrated commuters, many of whom had to walk, pedal or rollerblade to work, urged Sarkozy to hang tough, saying France needs economic reforms to thrive. With Sarkozy in power for just six months, the strikes represent the first major union challenge to his plans to modernize France – and he said Wednesday he wanted the strikes to end quickly.
Rail and transport workers unions vowed to press the walkout into a fourth day today, as the government sought to trumpet figures showing that support was fading.
"Today, there are twice as many buses as yesterday, twice as many trains as yesterday, more subways than yesterday," said Labor Minister Xavier Bertrand at the Senate.


text:
Moody Radio produces a variety of daily and weekly programs showcasing Christian music that is familiar, meaningful and popular with listeners. Moody Radio's balanced mix of music heavily relies on praise and worship songs and hymns that our listeners know and love, many of which are sung regularly in churches today. Our music is an enjoyable blend of inspirational and contemporary favorites from many of today's most popular Christian music songwriters, singers and groups, and listeners can trust Moody Radio's music to be lyrically sound. We also feature specialty programs on Saturday and Sunday nights to reach out to a wider audience, showcasing urban gospel on Celebration of Praise, and classic Christian songs with Faith on Record. At Moody Radio, inspirational music is another way we help listeners take the next step in their walk with Christ.
Times are posted in Central time.
November 5, 2017 November 6, 2017 November 7, 2017 November 8, 2017 November 9, 2017 November 10, 2017 November 11, 2017 November 13, 2017 November 14, 2017 November 15, 2017 November 16, 2017 November 17, 2017 November 18, 2017 November 19, 2017 November 20, 2017
Celebration of Praise is a weekly four-hour program that endeavors to bridge music divides and unite Christians in worship. Hosted by Roy Patterson, Celebration of Praise encourages listeners to remember that heaven will be a place of diverse worshipers from every tribe, nation and kind.
Bill Davis takes this time to dig into Moody Radio's album archives to bring back some of the inspirational classics from the 70s, 80s and early 90s—songs and artists we don't hear as much anymore. Join Bill for this three-hour musical flashback as he brings back the music of a generation!
Music for Saturday is a weekly four-hour program, hosted by Donna Leland, that encourages listeners to reflect on God's goodness through music and devotional thoughts.
Music for Sunday is a weekly six-hour program, hosted by Roy Patterson and Nancy Turner, that encourages listeners to reflect on God's goodness through music and devotional thoughts.
Hosts: Roy Patterson and Nancy Turner
Praise & Worship features uplifting Christian music—a mix of new and past favorites, great hymns of the faith, and praise anthems sung in churches across the globe. You will hear music from artists like Hillsong United, Chris Tomlin, Elevation Worship, Kari Jobe, Bethel Music, David Crowder, Jesus Culture, MercyMe, Gateway Worship, Michael W. Smith, Selah, and more. Lyrics that will speak to your soul and melodies you can sing along with.
Sunday Praise is a weekly three-hour programm, hosted by John Hayden, that prepares listeners to worship Jesus in their respective Sunday services. This program helps listeners remember who they are in Christ, and focus on what is lasting and truly important.
The Word in Song is an evening music program, hosted by Donna Leland, that features praise and worship selections, as well as inspirational favorites. This program helps us to focus our eyes on Jesus Christ and live our lives to please Him.


text:
KAMLOOPS - The three award categories for the Mayor's Awards for the Arts have been released and are open for submissions.
The categories are: artist of the year (performing arts), emerging artist (artist, musician, or performer aged 18 to 35), and business in support of the arts.
This is the tenth year the Kamloops Art Gallery, Western Canada Theatre and the Kamloops Symphony have worked together with the City of Kamloops to host the Mayor's Gala for the Arts.
Nominations can be submitted through the Mayor's Gala for the Arts website. Submissions must be in by Friday, Sept. 30, at 5 pm.
Last year's winners include Kelsey Gilker (emerging artist), Accent Inns (business in support of the arts), Amanda Eccleston (craft and design), and Vaughn Warren (craft and design).
To contact a reporter for this story, email Kim Anderson or email the editor. You can also submit photos, videos or news tips to the newsroom and be entered to win a monthly prize draw.
We welcome your comments and opinions on our stories but play nice. We won't censor or delete comments unless they contain off-topic statements or links, unnecessary vulgarity, false facts, spam or obviously fake profiles. If you have any concerns about what you see in comments, email the editor in the link above.


text:
Web hosting and cloud provider Rackspace (www.rackspace.com) announced on Monday it has launched OpenStack, an open-source cloud platform designed to foster the emergence of technology standards and cloud interoperability.
Rackspace is donating the code that powers its Cloud Files and Cloud Servers public-cloud offerings to the OpenStack project.
The project will also incorporate technology that powers the NASA Nebula Cloud Platform (http://nebula.nasa.gov).
Rackspace and NASA plan to actively partner on joint technology development and leverage the efforts of open-source software developers worldwide.
OpenStack will feature several cloud infrastructure components including a fully distributed object store based on Rackspace Cloud Files, which is now available at OpenStack.org.
The next component planned for release is a scalable compute-provisioning engine based on the NASA Nebula cloud technology and Rackspace Cloud Servers technology, which will be available later this year.
Organizations will be able to use these components to transform physical hardware into scalable and extensible cloud environments using the same code that helps serve tens of thousands of customers and large government projects.
"We are founding the OpenStack initiative to help drive industry standards, prevent vendor lock-in and generally increase the velocity of innovation in cloud technologies," says Lew Moorman, president of cloud and CSO at Rackspace. "We are proud to have NASA's support in this effort. Its Nebula Cloud Platform is a tremendous boost to the OpenStack community. We expect ongoing collaboration with NASA and the rest of the community to drive more-rapid cloud adoption and innovation, in the private and public spheres."
Rackspace and NASA have committed to use OpenStack to power their cloud platforms, and Rackspace will dedicate open-source developers and resources to support adoption of OpenStack among enterprises and service providers.


text:
His quizzes
User hasn't taken any quizzes
Profile link:
Story about Ilar Mäda
My name is Ilar Mäda, I'm male and 33 Years old. My Sign of Zodiac is scorpio. I live in Nulla Nulla, Australia. On Flirtic.com I've been registered for 09.12.2012 years.
If our iterests match, you can send me a message, make a gift or invite for a date.
I speak estonian. My mother tongue is estonian.
Ilar Mäda
Was online 27.08.2013
He is not a VIP user. Send him VIP as a gift »
|Aim of acquaintance:
|Yet to be answered
|Interested in:
|Native language:
|Response rate
|very low
Do not participate in Top 100. Reason:
Has no profile pictures


text:
Shadowing Opportunities:
Shadowing opportunities at Sunnyslope will begin October 2nd, 2017. You may begin sending in requests at the end of September, 2017.
Second semester we will begin scheduling shadows in February-April 13th.
Sunnyslope High School has a shadowing program available to students who are interested in being a part of our campus for a day. This is an opportunity for students who are not enrolled at Sunnyslope to see our school climate, and amazing classes, by following a Viking Link Crew member through their day. Our Link Crew members are all upperclassman. Unfortunately we do not allow requests of students so that all Link Crew Members get an equal amount of shadows. We do try and match based on gender and academic level. Scheduling is flexible between full days and half days.
To get your student signed up, please fill out the attached form by clicking HERE and submit it to Victoria Christensen, a counselor at Sunnyslope High School. Please email the form to firstname.lastname@example.com or fax the form to 623.915.8762. For general questions you can contact Mrs. Christensen at 623.915.8777.
Parents who are interested in taking a tour of our school with your students, please contact our Assistant Principal, Mr. Todd Nelson at 623.915.8766.
**Disclaimer: students within the GUHSD boundaries will not be allowed shadowing opportunities until after future freshman night on January 19th.