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The Art of Stewardship
The Arts have always had the ability to transcend language, culture, and the centuries. Since the dawn of our collective human memory, art in its myriad forms has expressed our hopes, our fears, and our loves while also serving as an interpretive record of the world around us. Then as now, the voice of Art remains a powerful communicative tool. In this, the new millennium, the realization that we indeed live on One World carries with it responsibilities never dreamt of by our distant ancestors as they expressed their visions on cave walls and with carved fertility icons. We now recognize the fragility of our planetary home and the profound role each of us plays in the drama of life on Earth. Now more than ever the Artist will play an ever-increasing part in a cast that must include
all of humanity.
The Art of Stewardship is in fact a calling out to those who speak the language that is universally understood. One that has the potential to raise awareness, inspire and celebrate our role as Stewards of our tiny oasis in space. At this point in history no challenge is more important or more immediate in nature. Our very survival depends on it. Knowing this, I call on artists worldwide to help bring the notion of Stewardship to the forefront of our conversations and consciousness.
- Greg Mort
Selections from the David H. Hickman Collection of Greg Mort paintings recently donated to the Academy Art Museum will be on display during the museum's 50th Anniversary exhibit. Celebrating 50 Years: Recent Gifts to the Academy Art Museum, September 13-November 1, 2008. For additional information visit: www.art-academy.org
Following the Artist Talk, Greg Mort will introduce
Purification: River Baptism and the Living River
a short documentary film premiering at The Prince Theatre. Encore
presentations of this documentary will be shown at the Prince Theatre on Friday,
October 3 at 7 pm and again on Saturday October 4 at 12 noon at no charge.
For additional information visit Greg
Mort's website at
www.gregmort.com or
for more information on the documentary visit


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Who is the 'reasonably maximally exposed' individual?Submitted by webEditor on Tue, 01/27/2009 - 12:50
By Marlene Lang
On June 2, 2008, the U.S. Department of Energy was expected to file its application with the Nuclear Regulatory Commission for a license to move ahead with building the nation a nuclear waste dump 90 miles outside of Las Vegas, near fault lines and only 8 miles from the site of a 1992 earthquake. And above the water table. Has anyone told the DOE that water flows down, and carries with it almost anything that crosses its path?
Three Mile Island Thirty Year Later: Accident Without An End; Industry Without AnswersSubmitted by webEditor on Tue, 01/27/2009 - 06:51
(Harrisburg, Pa) - The core meltdown at Three Mile Island Unit-2 (TMI) beginning on March 28, 1979 ignited a fierce debate about the role of commercial nuclear power.
Eric Epstein, Chairman of TMI-Alert said, "In the three decades following the melt down, Americans have been exposed to a mercurial flow of misleading information relating to nuclear power. Nuclear energy is not a safe, secure or economical source of energy."
Andrew Stein, TMIA's economist, stated: "Three core problems and unresolved questions associated with nuclear power production continue to bedevil the industry:
"Where is the waste going to go?"
"Where is the water going to come from?"
"Why is 'Wall Street' sitting on the sidelines?"
Stein added, "In the last decade, costs associated with security, fuel, labor and nuclear waste disposal have priced nuclear power out of the marketplace."
The Next Nuclear Bailout: Cleaning Up Pennsylvania's Nuclear Power PlantsSubmitted by webEditor on Mon, 01/12/2009 - 18:19
By Eric Epstein
Three Mile Island Alert, Inc. (TMIA) has been actively involved with issues pertaining to nuclear decommissioning since the March 1979 accident at Three Mile Island (TMI) Unit-2. Specifically, We've asked: Who should pay the cost of nuclear decommissioning and radioactive waste management?
25 years after the accident, here's what was saidSubmitted by TMIA on Mon, 01/12/2009 - 14:30
Just because a quarter-century has passed since the accident at Three Mile Island doesn't mean we should shut up about it.
SARA KELLY, Philadelphia Weekly, March 3, 2004
"It was the first step in a nuclear nightmare..."Submitted by TMIA on Mon, 01/12/2009 - 14:07
The CBS Evening News began with these words
from Walter Cronkite on March 28, 1979
Chart of Radioactive PlumeSubmitted by TMIA on Mon, 01/12/2009 - 13:58
This radioactive plume measured via aerial surveillance on March 31, 1979 shows just how narrow the path of radiation travel can be. Releases passing between the stationary ground-based monitors went undetected in 1979. The narrow plume path also explains why health effects can be found in one neighborhood and not another.
As charted by the Lawrence Livermore Laboratory
Three Mile Island Witness TestimonialsSubmitted by TMIA on Mon, 01/12/2009 - 12:44
The following three testimonials are from "Three Mile Island: The People's Testament," (1989), a series of interviews with approximately 250 Three Mile Island (TMI) area residents from 1979 to 1988 done by Katagiri Mitsuru, Professor of Social Psychology at Kyoto Seika University and Aileen M. Smith, free-lance journalist and co-author of the book Minamata.
Marie Holowka, Farmer, Zion's View, PA
Report of the President's Commission on The Accident at Three Mile IslandSubmitted by TMIA on Mon, 01/12/2009 - 11:53
The Nuclear Accident at Three Mile Island: Day 4Submitted by TMIA on Mon, 01/12/2009 - 11:48
Saturday March 31, 1979
The Nuclear Accident at Three Mile Island: Day 3Submitted by TMIA on Mon, 01/12/2009 - 11:44
Friday March 30, 1979

subset: commoncrawl


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Video Installation
View from the High Line Park of Studio Windows
New York, NY
CREEPS is a site-specific performance and video installation viewed from New York's High Line Park. It features three masked women that are projected on the windows of Hovnanian's studio overlooking the High Line. From below, these eerie human illusions are seen smoking, eavesdropping, and laughing at passers-by. Along with the video projections, CREEPS includes a performative element in which an actress identically dressed to the masked woman hides in the bushes by the High Line Park while spying on people through binoculars. These women, masked and dressed in sterile robes and a platinum wig, personify the "otherization" of the three ethereal counterparts above, blurring the distinction between the viewers and the viewed. CREEPS depicts society's insatiable need to be everywhere and know everything ceaselessly, questioning our notion of privacy and calling attention to the pervasive surveillance in the lived and dual realities we inhabit. The viewer is crucial and constitutive to the work- without their response, there is no reflection.


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Senator Houde sponsored SB 390, relative to health insurance premium only cafeteria plans, which provides a mechanism for employers to establish and maintain a section 125 plan for its employees to use to purchase health insurance. Supported by the NH Business and Industry Association, such plans are not only a good way for an employer to extend healthcare benefits to employees if the employer does not currently offer health insurance, but also would enable employers to save money in payroll taxes since contributions by the employee are made on a pre-tax basis.
SB 505 established a Health Care Cost Containment Commission, charged with looking at the health care reimbursement system, including the impact of federal health care reform, options for implementing a common payment system and ways to encourage the use of incentives to improve quality and efficiency. Goals of the commission include finding ways to promote competition in health insurance, reduce or eliminate payment differentials, ensure access, fairly allocate the burden of charity care, promote public access to cost information and contain the increase in health care costs. The costs will be covered by a one-time assessment, with half paid by insurers and the other half paid by hospital and ambulatory surgical centers in proportion to their net operation revenue.
SB 42 enables Medicaid patients to get the benefit of hospice care at the end of life. New Hampshire was one of the last states to offer hospice care under Medicaid. Hospice care is generally more cost-effective that hospital care and provides coordinated and comprehensive services to dying patients and their families, including home care, bereavement counseling, pain management and symptom control. Some hospice organizations also have facilities where they provide medical care and services to dying patients outside of a hospital or nursing home.
Source: http://www.matthewhoude.com/custom?key=1622


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The Pyramid Texts Trailer (2015)
If we have been remiss in our life, and hurt the people we most love, is it ever too late to redress the balance? Ray, a lonely old boxer, desperately estranged from his son, records his loves, his regrets, and his greatest life lessons to a camera in an empty boxing gym. His is the desperate hope that no estrangement is permanent, and that it is never too late to say sorry.
Watch the official The Pyramid Texts 2015 trailer in HD below or find more The Pyramid Texts videos on Vidimovie.


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EC sludge proposals softened but metals threat remains
Proposals by the European Commission to revise the 1986 EC Directive on use of sewage sludge in agriculture have been altered following consultation with Member States. Deadlines for meeting proposed limits on metals have been relaxed, but the threat of tighter standards in the future remains. The Department of the Environment, Transport and the Regions (DETR) says that the proposals would cut sludge spreading on farms and double the amount of sludge incinerated in the UK.
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Honeymoon murder suspect Shrien Dewani 'wants to face trial for bride murder'
HONEYMOON murder suspect Shrien Dewani wants to return to fight the case against him in South Africa, his extradition hearing was told yesterday
The Briton accused of plotting the killing of his bride, Anni, has hinted at going back as his health has improved, Westminster Magistrates Court heard.
Dewani, 33, who was not in court, has avoided extradition on the grounds that he has post-traumatic stress disorder, depression and suicidal tendencies.
But South African prosecutors believe it would not now be oppressive to fly the businessman to stand trial in Cape Town.
Hugo Keith QC said: "We suggest that there has been significant and sustained improvement. There are more positive observations about how he wishes to return to fight the case."
We suggest that there has been significant and sustained improvement. There are more positive observations about how he wishes to return to fight the case
Dewani, of Bristol, is being treated in a mental hospital and was declared unfit to stand trial.
But Mr Keith said that his medication and therapy have been so successful that his trauma is moderate to severe rather than severe.
Although he struggles to concentrate and remember details, he no longer makes active references to suicide.
Dewani, a care home operator, was excused from attending yesterday's hearing but his father, Prakash, and brother Preyen were present.
His late wife's father, Vinod Hindocha, sister Ami Denborg and brother Anish Hindocha also watched from the public gallery, along with other relatives.
Swedish-born Anni, 28, was murdered in November 2010, three days after the couple arrived in Cape Town for their honeymoon.
She was shot dead by thugs who stopped the newlyweds' taxi and abducted her.
Xolile Mngeni, 25, and Mziwamadoda Qwabe, 27, were jailed for life and 25 years respectively.
Taxi driver Zola Tongo, who claimed Dewani paid him to arrange the killing, got 18 years.
Dewani's lawyers have claimed he would be a high suicide risk if extradited.
They also claim he would be at risk of being violently attacked and sexually assaulted in jail.
The hearing continues.


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Time is of the essence when it comes to emergency restoration and cleanup following a disaster. Fortunately, Paul Davis Restoration of Tallahassee provides a free restoration contingency solution for facility directors, risk managers, and property managers called First Priority.
Our staff has the necessary tools to understand how to accurately restore businesses damaged by fire, wind, water, and natural disasters in Tallahassee. We understand the value of returning the efficiency and profitability of your property with minimal disruption, which is why we ensure a complete return to a pre-loss condition or better.
Included in the Paul Davis First Priority Program are:
• Priority service during a catastrophe
• Pre-loss planning
• Insurance carrier consultations
• Complete emergency reconstruction services
Don't wait until it is too late; prepare your business for a disaster before it strikes with the First Priority Program. To help prevent future damage, facilitate disaster recovery, and minimize loss of revenue, we'll proactively develop a customized plan. By creating a plan, you make sure that your business gets back on its feet as quickly as possible with minimal interruption in your daily operations.
Learn more about the First Priority Program.


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Faculty are responsible for developing specific research projects and groups, as well as obtaining research funding. Research funding opportunities exist through a variety of channels including:
PI is investing heavily in human and physical research infrastructure. To support research management at PI the R&D organization been divided into 3 main areas:


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Mushroom 'n Beer Mac 'n Cheese
Recipe courtesy of the Mushroom Council and mushroominfo.com
Yield: 6 servings
16 ounces penne pasta, uncooked
1 pound white button mushrooms, quartered
12 ounces beer, divided
4 tablespoons butter
¼ cup all-purpose flour
2 teaspoons mustard
½ teaspoon salt
3 cups milk
3 cups shredded sharp cheddar cheese
¼ cup fresh breadcrumbs
Preheat oven to 350° F. Cook pasta according to package directions.
While pasta cooks, sauté mushrooms in 1/2 cup beer in a large non-stick skillet. When liquid has evaporated and one side is red-brown, flip mushrooms and cook until other side is same color, about 20 minutes.
Melt butter in a large saucepan and stir in flour. Cook for a minute or two to slightly toast flour. Stir in mustard and salt, then whisk in milk and remaining beer. Bring to a low boil over medium-high heat, stirring occasionally to slightly thicken sauce, for about five minutes. Remove from heat, whisk in cheese and stir to melt. Stir in mushrooms and pasta and transfer to flameproof skillet or Dutch oven. Sprinkle with breadcrumbs.
Place skillet or Dutch oven on baking sheet and bake until cheese bubbles around edges, about 30 minutes. Remove from oven, cover and transport to tailgate, wrapped in blanket or large towel. Reheat on a grill or serve slightly warm.
Check out our Recipe of the Week feature on the Mushroom Channel.
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Gustafson Brothers Service Center
ReScore Reviews™ (2)
99% Would Recommend
Latest Review 2 days ago
Review for Gustafson Brothers Service Center
Delaney O. on 05/25/2011
Spoke with William. He said the service was good but a little bit pricey. He was charged $377 for a starter. There was no certain time for the vehicle to be ready but was done quickly.
Category: Service
Service Date: 05/17/2011
Review Created: 05/25/2011
This review was collected via phone interview by Customer Research Inc.


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Digital Storytelling Encourages Chinese EF Learners' Speaking Practice. Bei Zhang Luo Ming Shantou University, China Email: [email protected] [email protected] Introduction. What is a Digital Storytelling? --Using multi-media tech as a tool to …express oneself
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Bei Zhang Luo Ming
Shantou University, China
Email: [email protected]
--Using multi-media tech as a tool to …express oneself
- Digital Storytelling Association
digital video clip, told in first person narrative, recorded with teller's own voice, illustrated with still images, text, recorded audio narration, video clips, and with an optional music track to add emotional tone.
From http://www.storycenter.org
Lambert 2002, Mellon, 1999,Meadows 2003, Caleb 2002
---Kathleen M. Bailey 2003
---Kathleen M. Bailey 2003
Digital Diner Press http://www.storycenter.org/


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IDA 7.6 – New Features: Pluglets ("Macros for Eclipse"). Contents. New Pluglets Feature in IDA 7.6 Pluglets, some background Install option "Run Pluglets" menu Installed Sample pluglets Develop Custom pluglets Trouble Shooting & Known Limitations Extra Slides Sample pluglet enablement
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Need for scripting/macros:
"Macros for Eclipse"
this controls the pluglet classpath, both at compile and at runtime
Java perspective:
Data Perspective:
See RSA v8 Documentation (link on last slide):
Known defects & limitations:


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- Please select a date to see the proper prices!
Description of the accommodation:
Rooms, services Have you never been to Brazil, or are you just looking to repeat a remarkable experience? Arco Hotel Ribeirão Preto I Ribeirao Preto would be pleased to host both you and your family for a stay. The hotel is welcoming all guests in Ribeirão Preto with 200 comfortable rooms to stay in. For those arriving by car parking is available nearby. In the safe your valuables may be the safely secured. The hotel is offering wireless Internet connection (WiFi) without charging extra fees, so you may go online anytime with your laptop during your stay. The exact scope of services offered by Arco Hotel Ribeirão Preto I Ribeirao Preto (including those for an extra fee) is available on the information sheet below.
Payment For the reservation you may need to provide advance payment by credit card or credit card guarantee, depending on the exact date, room and price.
Arrival, opening hours The earliest time to arrive is 14:00, the latest time to leave the rooms is 18:00. The personnel of the hotel can speak in Portuguese - Portugal and English with you.
Arco Hotel Ribeirão Preto I Ribeirao Preto rooms Rooms
- Please select a date to see the proper prices!
Accommodation services
Free WiFi in shared places
Elevator, Safe deposit box


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|Home | About | Journals | Submit | Contact Us | Français
Liquid cultures of the basidiomycetous fungus Gloeophyllum striatum were employed to study the biodegradation of pradofloxacin, a new veterinary fluoroquinolone antibiotic carrying a CN group at position C-8. After 16 days of incubation, metabolites were purified by micro-preparative high-performance liquid chromatography. Four metabolites could be identified by co-chromatography with chemically synthesized standards. The chemical structures of three compounds were resolved by 1H-nuclear magnetic resonance spectroscopy plus infrared spectroscopy in one case. All metabolites were confirmed by high resolution mass spectrometry-derived molecular formulae. They comprised compounds in which the carboxyl group or the fluorine atom had been exchanged for a hydroxyl group. Furthermore, replacement of the CN group and the intact amine moiety by a hydroxyl group as well as degradation of the amine substituent were observed. The chemical structure of a catechol-type fluoroquinolone metabolite (F-5) could be fully defined for the first time. The latter initiated a hypothetical degradation sequence providing a unique metabolite, F-13, which consisted of the cyclopropyl-substituted pyridone ring still carrying C-7 and C-8 of pradofloxacin, now linked by a double bond and substituted by a hydroxyl and the CN group, respectively. Most likely, all reactions were hydroxyl radical-driven. Metabolite F-13 proves fungal cleavage of the aromatic fluoroquinolone core for the first time. Hence, two decades after the emergence of the notion of the non-biodegradability of fluoroquinolones, fungal degradation of all key structural elements has been proven.
Pradofloxacin (PRA), a new fluoroquinolone (FQ) drug, is used to treat bacterial infections in cats and dogs Litster et al. 2007;Mueller and Stephan 2007. It shares the core structure of common cyclopropyl-type FQs Domagala and Hagen 2003 but carries a cyano group at position C-8 and a bi-cyclic amine at C-7, S,S-pyrrolidinopiperidine ([1S,6S]-2,8-diazabicyclo[4.3.0]non-8-yl); the latter is also contained in moxifloxacin Petersen 2006. Concerning in vitro antibacterial activity, particularly low mutant prevention concentrations of PRA suggest a high potential for preventing the emergence of resistance under therapy Wetzstein 2005. Both substituents in combination are essential for its improved efficacy Wetzstein and Hallenbach 2011. Furthermore, the CN group facilitates hydrolytic elimination of the amine moiety (i.e., drug inactivation) under the slightly alkaline conditions present in decaying animal waste Wetzstein et al. 2009. Hence, PRA should be more readily biodegradable and thus ecologically favorable than conventional FQs.
Fungal degradation of FQs such as ciprofloxacin Wetzstein et al. 1999, enrofloxacin Karl et al. 2006 and moxifloxacin Petersen 2006 under defined in vitro conditions has been described in detail. However, all findings yet reported concerned decomposition of the amine substituent located at C-7 and the pyridone part of the FQ core. Eighty-seven metabolites of enrofloxacin produced by Gloeophyllum striatum DSM 9592, a basidiomycetous fungus causing brown rot decay of wood by employing a Fenton-type reaction mechanism Jensen et al. 2001;Qui and Jellison 2004, could be resolved: The chemical structures of 18 metabolites were fully elucidated, while 69 metabolites needed to be postulated based on their molecular formula, retention time and the most likely chemical context Karl et al. 2006. Forty-eight additional metabolites were generated by seven taxonomically diverse Basidiomycetes indigenous to agricultural sites, including Agrocybe praecox DSM 13167 from soil Wetzstein et al. 2006. Two postulated cis,cis-muconic acid-type congeners of enrofloxacin, metabolites 78 and 79 in Karl et al. (2006), came closest to implying aromatic ring cleavage to have occurred. However, although chemically more stable, the latter metabolites may, alternatively, be formulated as tetra-hydroxylated constitutional isomers. Hence, stringent evidence proving biodegradation of the aromatic core part of a FQ has not yet been reported. Our aim was to characterize the basic degradation scheme for PRA in G. striatum and to attempt the identification of new types of metabolites, to be expected due to the presence of the cyano group at position C-8.
Mycelia of G. striatum DSM 9592 were grown in a fourfold diluted malt broth, washed and then re-suspended in a defined mineral medium to give a concentration of about 2 mg dry weight per mL, as has been described previously Wetzstein et al. 1997. The culture vessels, screw-capped 250-mL Duran® glass bottles, contained 30 mL of mycelial suspension but were otherwise identical with those described before. PRA was added at 27 ± 0.5 μg/mL, labeled with either 1.4 or 1.9 MBq of [2-14C]PRA or [pyrrolidinopiperidine-7-14C]PRA, respectively Wetzstein et al. 2009. Both compounds had a radiochemical purity of > 98%. Cultures were then incubated at room temperature in the dark. 14CO2 produced was quantified as described before Wetzstein et al. 1997.
Emerging metabolites were monitored by high-performance liquid chromatography (HPLC), as described elsewhere Wetzstein et al. 1997. The former eluent system was slightly modified in that the aqueous component A contained 10 mM ammonium formate, 1% formic acid and 1% isopropanol; once again, acetonitrile served as component B. By adding B, component A was linearly decreased to 94% between 2 and 5 min, then to 85% over 9 min, to 70% over 15 min, to 50% over 5 min, and to 0% over 10 min. A shallower gradient (B) needed to be applied during co-chromatographic identification of the metabolites as well as micro-preparative purification of single metabolites from collected peak fractions. The HPLC gradient was modified as follows: By adding compound B, component A was linearly decreased to 94% over 5 min, to 88% over 10 min, to 82% over 15 min, to 75% over 15 min, and to 50% over 5 min. In order to identify metabolite F-10, [pyrrolidinopiperidine-7-14C]PRA needed to be provided as substrate. In case of F-10, component B consisted of 10% of acetonitrile in methanol (vol/vol). The flow rate was 1 mL/min, throughout.
Mycelia were separated by centrifugation and the resulting pellets washed with 50 mL of sterile water. The combined supernatants were passed through a 0.45 μm pore-size filter, then freeze-dried and re-suspended in 2 mL of distilled water. Metabolites could be isolated from such stock solutions by micro-preparative HPLC and manual collection of the relevant gradient fractions. After checking purity by HPLC analysis, metabolites were concentrated again by freeze-drying and re-suspended appropriately for structure determination.
HPLC-mass spectrometry (HPLC-MS) was performed as described previously Wetzstein et al. 1997. To characterize F-10, an isocratic mobile phase was used consisting of equal volumes of 25 mM ammonium acetate in water and methanol. Proton nuclear magnetic resonance (1H-NMR) spectra were recorded at 500 MHz in D2O containing 5% (vol/vol) of trifluoroacetic acid-d1, with acetone serving as an internal standard set at δ = 2.16 ppm Wetzstein et al. 1997. High-resolution mass spectrometry (HR-MS) and determination of the molecular formula have been described by Karl et al. (2006). Fourier transformed infrared spectroscopy (FT-IR) specifically indicated the presence of the conjugated nitrile group in PRA by absorbance at 2205 cm-1. Of metabolite F-13, a sample of about 10 μg was imbedded in a micro potassium bromide disc. This was analyzed by using a UMA 500 microscope mounted to a FTS 60A spectrometer (Bio-Rad, Krefeld, Germany).
After 8 weeks, 14CO2 production from [2-14C]PRA and [pyrrolidinopiperidine-7-14C]PRA, applied at 10 μg/mL, had reached 34.3% ± 2.7% and 6.3% ± 1.0% of the initially applied 14C-label (average ± SD for three cultures). The kinetics were almost identical to those described previously for [2-14C]enrofloxacin and [piperazine-2,3-14C]enrofloxacin, respectively. Hence, the data are not shown in detail, but see Figure 2 in Wetzstein et al. (1997).
Chemically synthesized reference standards could be employed to identify F-1, F-6 and F-9 by co-chromatography (Figure (Figure2).2). F-1 and F-6 were identical with congeners of PRA, mono-hydroxylated at C-3 or C-8, respectively. Hydroxyl radical-driven elimination of the CN group, providing metabolite F-6, is notable. F-9 indicated complete degradation of the amine moiety with the C-7 amino group remaining attached to the FQ core part (Figure (Figure3).3). Following isolation of F-1, F-6 and F-9 by micro-preparative HPLC, their structures were confirmed by HR-MS-derived molecular formulae and 1H-NMR analysis as well (not shown). Molecular weights, retention times and characteristics of the absorption spectra of all metabolites are compiled in Table Table11.
HPLC analysis of 16-day-old supernatant revealed the pattern of PRA metabolites produced (Figure (Figure1).1). Based on previous findings, six major metabolites were designated F-1, F-2, F-5, F-6, F-9 and F-13; F denotes a type of fungal metabolite with proven chemical structure. Their concentrations amounted to 9% (F-2), 2 to 3% (F-1, F-5), and about 1% (F-6, F-9, F-13) of the 14C-label applied. Upon prolonged incubation (e.g., after 42 days), the concentrations of F-1, F-2, F-6 and F-5 (three mono and one dihydroxylated congeners, respectively; see below) declined extensively, while those of F-9 and F-13 remained essentially constant. At that point, even PRA had reached the concentration level typical of major metabolites. Hence, supernatants of four parallel cultures were harvested on day 16. The 14C-label recovered in the combined supernatants amounted to 92% of the activity applied.
Due to their instability, no reference compounds were available of F-2 and F-5. However, the NMR spectrum of F-2 showed two singlets (Table (Table2):2): one, assigned to the proton at position C-5 (δ = 7.64 ppm), proved the absence of fluorine, while the other was due to the proton at C-2. The molecular weight, reduced by two atomic mass units (Table (Table1),1), was consistent with a replacement of fluorine by a hydroxyl group. For F-5, only one singlet was observed in the aromatic region of the NMR spectrum (Table (Table2):2): this was to be assigned to the proton at C-2. An increase in the molecular weight of 14 (Table (Table1),1), implying the replacement of fluorine by a hydroxyl group and the addition of one oxygen atom at position C-5, implicated the catechol-type congener F-5 (Figure (Figure3).3). The identity of F-2 and F-5 was confirmed on the basis of their molecular formulae determined by HR-MS (data not shown).
Identification of metabolite F-13, 6-[(E/Z)-1-cyano-2-hydroxyethenyl]-1-cyclopropyl-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid (Figure (Figure3),3), was based on (i) its exact mass, [M+H]+ = 247.0719, equating to the molecular formula C12H10N2O4; (ii) three singlets in the aromatic region of the NMR spectrum, assigned to H-5, H-2 and H-2' (Table (Table2);2); (iii) NMR signals of all protons of the cyclopropyl moiety (data not shown); and (iv) specific peaks of absorbance of the CN group at 2189 and 2218 cm-1 in the FT-IR spectrum. However, whether the hydroxyl group at C-2' was located in cis or trans position to the CN group remains to be elucidated.
The application of [pyrrolidinopiperdine-7-14C]PRA as substrate to be degraded facilitated the identification of a seventh major metabolite, F-10, the intact pyrrolidinopiperidine substituent. Its characterization proceeded exactly as has been described for the piperazine residue of enrofloxacin; see Figure 4C in Wetzstein et al. (1997). F-10 was identified by co-chromatography, employing a chemically synthesized standard (not depicted), and confirmed by determination of its molecular weight (Table (Table11).
It should be mentioned that the quantities of six additional metabolites of PRA were too small to permit comprehensive structure elucidation. Retention times and HR-MS analysis-based molecular formulae suggested the presence of (i) one additional congener each of PRA and F-1, most likely carrying a mono and a dihydroxylated amine substituent; (ii) F-2, to which one oxygen atom had been added but water eliminated; and (iii) F-9, in which fluorine was replaced by a hydroxyl group; a labile ortho-aminophenol-type metabolite resembling key metabolite 77 of enrofloxacin (see Figure 5 in Karl et al. [2006]).
The basic metabolic pathway of PRA, a new veterinary FQ antibacterial drug, in the brown rot fungus G. striatum was similar to schemes established for other FQs such as enrofloxacin, ciprofloxacin and moxifloxacin. Hydroxylated primary metabolites of PRA, each representing a different class of compounds (Figure (Figure3),3), were generated by hydroxyl radical-based decarboxylation (F-1), defluorination (F-2) and elimination of CN (F-6). The definitive identification of a catechol-type FQ congener, compound F-5, carrying one hydroxyl group each at C-5 and C-6, is described here for the first time. This was facilitated by the CN substituent blocking C-8, in contrast to F-5 of enrofloxacin Wetzstein et al. 1997 or ciprofloxacin Wetzstein et al. 1999, for which hydroxylation of position C-5 was indistinguishable from hydroxylation of C-8. Degradation of the amine substituent is represented by F-9.
The identification of metabolite F-13, consisting of the cyclopropyl-substituted pyridone part and C-atoms 7 and 8 of PRA, now linked by a double bond and carrying a hydroxyl and the CN group, respectively, proved fungal cleavage of the aromatic FQ core for the first time. The presence of a conjugated CN group was verified by IR-spectroscopy. Being part of a mesomeric system, the CN group is likely to have stabilized metabolite F-13 sufficiently as to permit its isolation and structure elucidation. The most likely intermediates, connecting F-5 with F-13 (Figure (Figure3),3), imply: (i) hydroxyl radical-based elimination of the intact amine moiety (F-10), a reaction already observed for enrofloxacin and ciprofloxacin Wetzstein et al. 1997; 1999; (ii) twofold oxidation of the resulting pyrogallol-type intermediate and the formation of a cis,cis-muconic acid-type analog; and (iii) spontaneous twofold decarboxylation, finally providing F-13. Metabolite F-13 adds a unique type of compound to the plethora of 137 known metabolites of enrofloxacin (including the ethylpiperazine residue and CO2) produced by basidiomycetous fungi Karl et al. 2006;Wetzstein et al. 2006.
Six major metabolites of enrofloxacin and, in particular, 8-OH-PRA (F-6) have been shown to essentially have lost antibacterial activity Wetzstein et al. 2009;Wetzstein and Hallenbach 2011. Most recent observations suggest that minimum inhibitory concentrations of 8-OH-PRA may have been slightly (less than twofold) overestimated, due to its instability at 37°C, resulting in a half-life of about 2 days (Wetzstein H-G, unpublished data). Regardless, FQ residues such as those described herein appear to be unlikely to pose a significant risk due to selection of resistance in agricultural soils Wetzstein et al. 2009;Baquero et al. 2011.
Recently, metabolites of norfloxacin hydroxylated at position C-6 and C-8 have been reported to be formed by Microbacterium spp. isolated from wastewater Kim et al. 2011. Moreover, from 8-OH-norfloxacin, C-8 may be eliminated by Candida palmioleophila LA-1 Kim et al., Abstr 111th Annu Gen Meet Am Soc Microbiol, abstr. Q-2943, 2011. The corresponding metabolite should be indicative of a mechanism of aromatic ring cleavage different from that believed to be observed in this study.
Metabolic inactivation of FQs in mammals predominantly comprises glucuronidation of the carboxyl group and sulfation of an appropriate secondary amine function, if present in the amine substituent. Furthermore, N-4'-dealkylation, formylation and oxide formation as well as partial degradation of the C-7 amine substituent have been observed. However, core-hydroxylated metabolites were not reported, as reviewed by Dalhoff and Bergan (1998). Another major mechanism of FQ inactivation is N-4'-acetylation, in case of enrofloxacin following N-4'-deethylation, as catalyzed by the Zygomycete Mucor ramannianus Parshikov et al. 2000. For G. striatum, only O-acetylated congeners have been observed, exemplified by metabolites 13 and 62 described by Karl et al. (2006). Chemically synthesized N-acetyl-PRA provides for MICs similar to those of 8-OH-PRA (Wetzstein H-G, unpublished observation). However, it is unknown, whether PRA could serve as a substrate for the bacterial enzymes yet described.
Most notable, acetylation of the piperazine residue of ciprofloxacin or norfloxacin by environmental strains of Mycobacterium Adjei et al. 2006a,b has not yet been found in clinical strains. Furthermore, a FQ-resistant strain of E. coli, isolated from sewage sludge, contained the aminoglycoside transacetylase gene aac(6')-Ib-cr and was capable of modifying ciprofloxacin by acetylation Jung et al. 2009. This activity was first observed to be a plasmid-encoded FQ-resistance factor in Gram-negative species Robicsek et al. 2006. N-acetylation as well as N-oxide formation Parshikov et al. 2000;Karl et al. 2006 eliminates the positive charge of the amine residue, present at physiological pH. The resulting FQ congener is negatively charged, thus drug accumulation into the cytoplasm may be restricted or even prevented.
Strangely enough, the apparently complex degradation scheme described for enrofloxacin Karl et al. 2006;Wetzstein et al. 2006 has to be considered a relatively simple example, compared to degradation patterns to be expected for PRA, moxifloxacin and any other FQ with a more complex amine substituent. Giving rise to the variety of constitutional isomers, the number of discernible H-atoms in the amine moiety, potentially to be replaced by a hydroxyl group, amounts to four for enrofloxacin, but already to twelve for the pyrrolidinopiperidine residue of PRA; this structural feature extends to metabolites carrying a combination of a hydroxyl and a keto group or even a cleaved amine moiety. Hence, definitive structure elucidation of such metabolites would have to be based on isolated compounds and required a formidable analytical effort.
In independent studies assessing the chemical degradation of enrofloxacin, ciprofloxacin or other FQs, cleavage of the aromatic core could not yet be proved either, if based on metabolite identification. Work on ciprofloxacin confirmed several key metabolites observed with G. striatum: (i) F-1, F-2, F-6 and F-9 in a membrane anodic Fenton-type system (Xiao et al. [2010]; see also references 19, 22 and 25, therein); (ii) isatin and anthranilic acid-type metabolites formed during ozonation (Dewitte et al. 2008; and (iii) metabolites indicating degradation of the amine substituent by hydroxyl radicals, generated upon UV-irradiation of TiO2 Paul et al. 2007. Under the latter conditions, cleavage of the cyclopropyl moiety was observed as well. This leaves unexplored fungal degradation of the cyclopropyl-substituent, which, however, is a natural product found, e.g., in the lipids of E. coli Goldfine 1982. Two decades after the emergence of the notion of the non-biodegradability of FQs, briefly reviewed by Wetzstein et al. (2009), fungal degradation of all key structural elements of a FQ, in particular of the aromatic core, now has been proven.
The authors are (HGW and JS) or have been (WK) employees of Bayer AG, as indicated.
HGW carried out the microbiological experiments and drafted the manuscript. JS determined the optimal experimental conditions and performed chemical analyses. WK guided structure elucidation and provided all interpretations of the chemical raw data. All authors read and approved the final manuscript.
Part of this work was presented at the 111th Annual General Meeting of the American Society for Microbiology, New Orleans, LA, 2011, poster Q-2773. We like to thank Peter Opdam and Kevin Yount for reading of the manuscript prior to submission, and Stefan Tessun for his ongoing help in preparing the Figures.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text: Heckler & Koch HK45 Tactical Semi Auto Pistol with TB **New** For Sale from PERRYS GUN SHOP | Positive feedback: 98% View | Verified Seller | 2139 Completed Sales View Sellers Items /UserImages/65593/902870514 8454020.jpg /UserImages/65593/902870514 8454021.jpg /UserImages/65593/902870514 8454022.jpg Description: Heckler & Koch HK45 Tactical pistol, .45 ACP with Threaded barrel. Originally developed for the U.S. military's next generation handgun competition the new HK45 "Tactical" comes standard with a threaded barrel and Meprolight three-dot tritium night sights. With a choice of three frame colors (green, tan, or black), the full-size HK45 Tactical (HK45T) model uses an ergonomic grip design that includes changeable backstraps together with molded finger grooves that instinctively position an operator's hand for optimum shooting. All HK45 pistol series (compact, full-size, Tactical models) are made at HK's American manufacturing facility in New Hampshire using American and German components. The HK45 Tactical uses a 10-round steel magazine and has a Picatinny MIL-STD-1913 rail molded into its polymer frame for mounting lights and accessories. The HK45 Tactical has a proprietary internal mechanical recoil reduction system that employs a flat recoil spring in tandem with a polymer bushing sleeve to reduce the recoil forces effecting the operator and the weapon, improving shooter control during rapid firing and prolonging component service life. An "O-ring" on the threaded barrel means better slide-to-barrel lockup and enhanced accuracy. Covered by Heckler & Koch's limited lifetime warranty, the HK45T is a robust design engineered with the famous long-term durability that make HK products especially cost-effective when subjected to total life cycle cost analysis. The patented HK Lock-Out system allows the operator to discreetly lock the pistol by inserting a pronged key into the magazine well and turning a control plate that blocks any movement of the slide, hammer, and the trigger. New $1289.99 Perry's Gun Shop is an owner operated family business with a long heritage of TOP QUALITY firearms and TOP QUALITY SERVICE. We are a stocking dealer and our 20,000 square foot store is nationally recognized by top manufacturers like Browning, Winchester, Beretta, Benelli, Smith & Wesson, Glock, Liberty Safes, Remington, H&K, and over 100 other brands. Sales to North Carolina residents will be subject to NC Sales Tax of 6.75%. All of the firearms that we have listed are also available in our retail establishment and thus are subject to prior sale in the store. Our business hours are 8:00am to 5:30PM Monday thru Friday and 8:00am until 3:30PM on Saturday. You may visit us on the web at anytime. Please include a signed copy of your receiving FFL's current license or it may be faxed to the number above. Be sure to include sufficient information with the faxed or mailed license so that we may identify and properly connect the FFL with your transaction. Regrettably, we are not able to offer trade-in's on our internet sales, however we do consider trades in our retail location. We only ship to Licensed Federal Firearms Dealers and we must have a copy of your receiving FFL's current license on file prior to shipment. There is no surcharge for Credit Cards. Sorry but we do not ship to California. Your patronage of our business is appreciated and our commitment to you is always our #1 concern! When reputation matters...PERRY'S GUN SHOP IS YOUR BEST CHOICE!!! Read More Condition: New In Box Caliber: .45 ACP Location: NC Trades Accepted: Trades welcomed in-store only--not online. 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According to Satish Gupta of Astrostocktips, textile stocks like Arvind, Century Textiles, Raymond, Sumeet Industries and Bombay Dyeing will get astro support.
By Satish Gupta of Astrostocktips
Today's Planetary Position: Moon will be transiting in Aries. Sun in Libra, Mercury & Jupiter in Virgo, Lord Rahu in Leo. Mars in Sagittarius. Lord Saturn & Venus in Scorpio. Ketu in Aquarius. Pluto in Sagittarius. Neptune in Aquarius & Uranus in Pisces.
Rahukal time: - 15:00 – 16:30
Following sectors will be receiving astrological support:
Textile: Arvind, Century Textiles, Raymond, Sumeet Industries, Bombay Dyeing etc
Disclaimer: The views and investment tips expressed by investment experts/astrologers on moneycontrol.com are their own, and not that of the website or its management. Moneycontrol.com advises users to check with certified experts before taking any investment decisions.


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Thanks for printing! Don't forget to come back to Trenton Systems Inc. for fresh articles!
BPG6714 PCI Express Backplane
The BPG6714 PCI Express backplane is a small form factor PICMG 1.3 backplane that supports a single or dual-processor single board computer, one x16 PCI Express slot driven with a x16 PCIe link and a x8 PCIe slot driven with a x4/x1 PCIe link. Both PCIe links are direct interfaces from the SBC.Request a Quote
- BPG6714 Backplane Features
- BPG6714 Backplane Tech Specs
- BPG6714 Backplane Download Documents
The BPG6714 PCI Express Backplane
The BPG6714 also features one 64-bit/133MHz PCI-X and two 64-bit/100MHz PCI-X option card slots that are driven with a dual-channel PCIe-to-PCI-X bridge chip. The PCI-X slots can also support universal PCI I/O cards.
Designed to fit into a small chassis or embedded inside an OEM machine, the shoebox layout provides the capability for rackmount computer and storage system designs to support multiple small form factor backplanes / single board computers within a single enclosure.
Key Features
Key features of the BPG6714 PCI Express backplane include:
- Shoe-box form factor with one PICMG 1.3 SBC slot
- 7-slot PCI Express backplane supports PCI Express and PCI-X/PCI plug-in I/O cards
- Supports up to two PCI Express option cards
- 1 – x16 PCI Express electrical / x16 mechanical driven directly from SBC
- 1 – x4/x1 PCI Express electrical# / x8 mechanical driven directly from SBC via the optional IOB33 module
- Link width is SBC dependent
- Supports up to three PCI-X/PCI option cards
- 1 – 64-bit/133MHz PCI-X
- 2 – 64-bit/100MHz PCI-X
The BPG6714 PCI Express backplane is designed and manufactured in Trenton's ISO 9001:2008 registered facilities and supported from within the USA. This small form factor PCIe backplane is supported by a 5-year factory warranty.
Tech Specs
Model Number
Form Factor
Small form factor, one segment
Board dimensions 6.8" x 12.9"
PCI Express Slots
One, x4/x1 PCIe slot (x8 mechanical) from a Trenton SHB via an IOB31 module
One, x16 PCIe slot (x16 mechanical) driven directly from SHB
Note: An MCG-series SHB provides a x4 PCIe link to slot PCIe1 and a TQ9, TML or T4L provides a x1 link
PCI-X/PCI Slots
One, PCI-X slot, 64-bit/133MHz
Two, PCI-X/PCI slots, 64-bit/100MHz
See datasheet or mechanical layout diagram for detailed slot routing information.
6.8″ x 12.9″
Card Slots
1 – x16 PCI Express 2.0/1.1 electrical / x16 mech. connector
1 – x4/x1 PCI Express 2.0/1.1 electrical# / x8 mech. connector
1 – 64-bit/133MHz PCI-X
2 – 64-bit/100MHz PCI-X
#From IOB3x on SBC / link width SBC dependent
Suggested SHB/SBCs
Dual-processor SBCs: BXT7059, JXT6966
Single-processor SBCs: TSB7053, TQ9, BXTS7059, JXTS6966
SHB Configuration
PICMG 1.3 Combo or Graphics Class
Agency Approvals & Compliance
Designed for UL60950 and CAN/CSA C22.2 No.60950-00
Power Connectors
Std. ATX/EPS power source:
1 – ATX/EPS connector
1 – 12V Aux connector
Power Indicators
+5V, -5V, +5V AUX*, +12V, -12V and +3.3V power connection and status.
Operating Temp: 0C to 60C
Storage Temp: -20C to 70C
Humidity: 5% to 95% non-condensing
Trenton's BPG6714 is a lead-free, RoHS compliant backplane


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Square Enix's Final Fantasy IX is arriving on Android soon. We never doubted that it's coming because past Final Fantasy games have been top favorites of Android gamers. We're excited to see the upgraded graphics and the actual gameplay. We're assuming this will be a premium app as with all other Final Fantasy games. As to how much, we have no idea yet.
Final Fantasy IX is a story of a war between nations. Zidane Tribal is a thief who wants to defeat Queen Brahne of Alexandria. He joins a group of warriors determined to beat the one who started the war–the Queen.
Some gameplays of the latest Final Fantasy are available on YouTube. Square Enix are showcasing the Final Fantasy IX and now we have a clue about the graphics quality. The video shows two Japanese commentators discussing the game. We don't understand Japanese but we learned the game will allow speeding up the scenes and will feature auto-save on the cloud. We can also expect that Square Enix will still use the ATB battle system.
No information yet on exact roll out date on the Play Store but when that day comes, we're sure thousands will download the game immediately no matter what the price will be.


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Excuse any errors. Its 1:30am and I am tired.
Seriously this article is a spoiler. I wanted your take on the film (meaning your opinion) not a scene by scene play-out of the entire movie. Why do people do this? It's so annoying.
SIDENOTE:I think the young director was trying to give the victim a face in the midst of all the chaos surrounding the days events that have over shadowed OSCAR GRANT's young misguided life. The film did just that.
I seen the actual video.... and I think that there was excessive forced used. There is never a justifiable reason to shoot a handcuffed man that's laying face-down PERIOD. There also is no justifiable reason to TASE a handcuffed man that's laying face-down PERIOD. SORRY. For anyone that disagrees.... Place handcuffs on yourself and lay face down and have someone TAZE you. Tell me how good it felt to be lucky enough to not be shot even though your in agonizing pain. Because that pain would have been a blessing for Mr. Grant.
Do I think it was intentional? Not necessarily. I can say this though..... this shows flaws in a system that allows people the option to carry guns and tasers that are not responsible enough to do so. If you don't have the smarts to know the differance between the two ....or atleast look before you squeeze the trigger.... you should not be patroling our streets. Its really that simple.


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The man who threatened to bomb a regular flight between Estonia and Germany in the name of Islamic extremists turns out to be a local Russian activist. Vladislav Pälling (33), known for his anti-NATO statements, is set to face trial today.
It took the Estonian Internal Security Service more than six months to catch up to Pälling who made a bomb threat against flights leaving for Germany in the name of ISIS on the night of July 25 last year. Even though Pälling made his threat in English using a local cell phone while in Estonia, it proved difficult to identify him.
Pälling had done everything possible to keep himself from being identified. Things were complicated by the fact the call was placed from a high-density residential area.
Tallinn resident Pälling was apprehended on February 2 and has now been arrested for a period of two months. He has confessed to the crime. The public prosecutor's office refuses to reveal Pälling's motives. The young man is facing trial today in agreement process, charged with aggravated breach of public order the maximum punishment for which is five years in prison.
Pälling has been seeking public attention for years by addressing both Russian President Vladimir Putin and U.S. presidents Barack Obama and Donald Trump. In the addresses, Pälling appears as an Estonian citizen appealing to heads of superpowers, asking them to prevent NATO inciting a war in Estonia as the former does not want to see his home town of Tallinn in ruins.
Pälling's message has only been published by propaganda publications with ties to Russia, principal among which is the Estonian web portal of Sputnik. Pälling's 2015 address to Obama can be found on YouTube where it has been viewed over 350 times. Pälling is also an activist of the Estonian Nations Party that has ambitions to represent Estonia's Russian-speakers.
On July 25, Pälling said that a plane headed for Germany would explode inside the next week. A threat seemingly by the Islamic State was regarded as extraordinary in Estonian context, and even though terror threat levels were low in Europe at the time, the call caused security forces to take additional security measures at Tallinn Airport. That is why apprehending the criminal who had so seriously breached public feelings of security became a matter of honor for Estonian investigative organs.


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Gorgeous busty brunette milf Shazia Sahari looks great in leopard print top
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Toe Walking
View Single Post
April 29th, 2013, 01:36 AM
Mega Super Mommy
Join Date: Dec 2010
Posts: 3,300
I used to do that as did my mother(actually we both still do) and we both have issues due to it.
We've had to have physical therapy and she is often in a lot of pain. I've been told many many times over the years to knock it off or I'll need hip and knee replacement when I'm 50. The issue is that the achilles(sp?) gets shortened when walking tip toe which leads to hamstring issues which basically connects everything from the toes to the mid back.
It's a habit we've had since forever.
Not sure there is a lot you can do about it.
Does she only do it when barefoot? If she doesn't stop, maybe sign her up for Yoga when she's 8 or something.
Even though I just wrote a whole bunch, I wouldn't worry about it. Just be aware that she may need some extra stretching and/or massage to offset any potential issues.
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NSG is expected to hold its next meeting in June
Pakistan's Foreign Affairs Advisor Sartaj Aziz said Islamabad's credentials for the membership of Nuclear Suppliers Group (NSG) are stronger than India's if the 48-nation cartel agrees to form a uniform criteria for non-Non Proliferation Treaty (NPT) states.
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Taking Advantage of Locations in California and Elkhart
Westport Fuel Systems has named A-1 Alternative Fuel Systems as its national distributor and installation partner for compressed natural gas fuel systems for shuttle and paratransit buses – one of the stronger markets for CNG. updated October 6
The move furthers a "longstanding relationship," notes Westport VP and managing director Paul Shaffer. The firms have done business together since the 1990s.
"We're taking this to the next level," Shaffer told F&F. "They'll be our national bus distributor."
A Ford QVM for Ford-Chassis Vehicles
"Given Westport's extensive background as a Ford-approved system manufacturer and A-1's depth of experience in the shuttle bus industry, this partnership makes a lot of sense," said A-1 national sales manager Will Gutilla.
"We are confident that together we will offer not only a high-quality product, but also tremendous post-delivery support to shuttle bus users all over the country."
Close to the Markets
The partnership is focused on Ford E-450 and F-450 and F-550 vehicles with the 6.8-liter V-10 engines.
Westport is attracted by A-1's location in Fresno, Calif., which is central to the big West Coast market, and in Elkhart, Ind., effectively the national capital for shuttle buses, Shaffer says. He notes too that A-1 is a Ford QMV – qualified vehicle modifier.
Contact information is only available to premium subscribers. Click here to purchase a subscription.
Source: Fleets & Fuels interview with Westport Fuel Systems


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Sometimes we roll out old footage for a reason and last night was just one of those nights up until the Nashville-Phoenix game. Maybe it was just us but every other game had some excitement but just did not wow us, maybe aside from the Buffalo ending with Tyler Myers scoring the game winner. However, there were a few fantasy standouts from last nignt and we should get started with naturally the Fantasy POTN.
Semyon Varlamov, G, Colorado Avalanche — Varlamov has really been on fire of late for Colorado and its just what Colorado needed at the most crucial time. Okay fantasy hockey fans probably needed it more considering how many still chose to suffer with Varlamov during the dog days of the hockey season. In a game that featured 73 combined shots and yet only two combined power plays, Semyon Varlamov stood tall stopping 38 of 40 shots, all in regulation. He kept Colorado in this game and when Gabriel Landeskog scored the game winner, Varlamov had won again. This gave him seven wins in his last nine starts and every start but one he has given up two goals or less. Tack in two shutouts along the way and Varlamov has been a steal in this critical stretch.
Tyler Ennis, C, Buffalo Sabres — The Sabres never get to overtime without Ennis, who notched two goals and looked every bit like the fantasy upside we had projected for him at the start of the year. Sure injuries and poor play have ravaged his season but Ennis has looked better of late. For your stretch run, this could be a guy that may at least merit a look. There is a very low ownership rate of a guy who has just had one of those years. Maybe he can at least help your team in this crucial 11th hour, err playoffs.
Martin Erat, RW, Nashville Predators — Something just was in the water last night in Phoenix as goals were coming from all over it seemed in the 5-4 Nashville win. However, Martin Erat was very good last night with a goal and two assists. Honestly he could have had a few more points as it was that kind of wide open hockey. Also the forward is on pace for a 60+ point season including 20+ goals which cannot be a complaint for his owners. If you add in that he potentially could amass 17-20 power play points, one has the very nice makings of a solid second RW option in fantasy leagues. Just imagine when Alex Radulov comes back.
Tuesday, March 13, 2012
|NY Islanders
|7:00 PM | Gameday
|New Jersey
|7:00 PM | Gameday
|Tampa Bay
|7:30 PM | Gameday
|NY Rangers
|7:30 PM | Gameday
|7:30 PM | Gameday
|8:00 PM | Gameday
|St. Louis
|8:30 PM | Gameday
|San Jose
|9:30 PM | Gameday
|Los Angeles
|10:30 PM | Gameday
Its the niner here on a Tuesday in your fantasy hockey leagues. Ian Gooding gives us the lowdown on his Pick Six for tonight done with a Wassel twist.
PICK SIX (Plus ONE):
So Sidney Crosby is poised to return on Thursday and hey Alex Radulov seems to be ready to come back as well. Is a Sean Avery sighting up next? Oh wait, that is not going to go over well. Again it is often said the fantasy landscape has some interesting wrinkles. This is the first impact night and the goal is just to give an idea of what is going on with a little commentary as well.
Detroit has the back to back and could not be more banged up. However they do get a major return in net. Expect Jimmy Howard to only play tonight and not on Wednesday against Anaheim. Nick Lidstrom (bone bruise on ankle) is not expected to play both games and is even questionable headed into the weekend. Sure Detroit insists there is improvement but these are the same people that insisted Henrik Zetterberg did not have a MCL strain when he clearly did. So wait and be vigilant.
There is no time better than the present to hop into this so let's hit the ground running…..shall we?
Sidney Crosby, C, PIT — START/ADD
In case there was doubt, Crosby is playing Thursday night against the New York Rangers and the impact is expected to be very high. Keep in mind that Crosby had 12 points in eight contests in return number one before a David Krejci "hit" sidelined him for the last three months. Yes this game is Thursday but is something necessary to mention right now so that fantasy hockey GM's get on the horn and do what they have to do. What will he do against the Rangers? A point or two seems like a safe bet and nothing like the four point (2 G 2 A) outburst against the New York Islanders in November.
Marty Turco, G, BOS — WATCH
It will be interesting to see how Turco fares in a full game at Tampa Bay tonight. Yes he gave up two goals in relief duty on Sunday against Pittsburgh but honestly did not look that bad and his puck handling did lead to some extra scoring chances. Yes he is still likely rusty but with the injuries in Boston at a season high and Tim Thomas's poor play, this start is very important to fantasy owners and at least worth a watch.
Alex Pietrangelo/Kevin Shattenkirk, D, STL — START
The best defensive duo lies in St. Louis and not whatever Ottawa throws out with Erik Karlsson or Shea and Weber in Nashville. It may just be Pietrangelo and Shattenkirk who have developed a unique chemistry (Seabrook and Keith like) and are over a point a game in their last five as a pair. Their +/- is very good and both will finish with over 45 points and 175 shots on goal along with a +20 (Shattenkirk may be a +30 or more). They are must haves on your blueline in this March of uncertainty with injuries.
Evgeni Nabokov, G, NYI — WATCH/BENCH
There are better goalie options out there at this point even if you did not climb aboard the Semyon Varlamov bandwagon. Nabokov tends to play well for stretches in games but almost always has those frustrating brain cramps. Everyone should remember his last game against Washington where he played great for 57 minutes then gave up three goals in the next several minutes in a crushing loss that likely ended any Islander playoff hopes. Yes the Russian is a good goalie but just has too many of those "Bryzgalov moments" on the ice.
Joe Pavelski/Patrick Marleau, W/C, SJ — BENCH
Yes San Jose needs the two points desperately but on the tail end of a back to back in the "Red Mile" is not exactly conducive to fantasy goodness. Add in these players have combined for 4 points in their last eight games and you have the recipe for another frustrating night in the fantasy hockey chase for a crown. It is a fantasy sprint now and having players that are dragging your team down can be very agonizing. Until they produce, it is time to let Pavelski and Marleau ride the pine. Hell you may want to consider giving Joe Thornton some pine splinters as well.
Stephen Weiss, C, FLA — BENCH
Weiss is struggling at the wrong time and some of it could be the injury to Kris Versteeg but whatever it is could be attributed to a "March Flop" that seems to happen to Weiss and maybe it is because normally this is the time where Florida drops out of playoff contention. After all they have missed the playoffs since 2000. He does traditionally heat up at the end of the month going into the end of the season however so its a temporary benching until he gets his fantasy act together.
Dmitri Orlov, D, WSH — START/ADD
Sometimes you just have to go a little outside the box and go with the hot hand. Orlov has four points in his last four games and seems to finally be realizing some of his pretty big upside in Washington. Sure he still has some very inconsistent stretches but his game overall has improved quite a bit from the start of the year. Going against an Islanders team who lost in very deflating fashion Sunday Night may be a good thing. Get him in your lineup and on your team before someone else does.
As always we have the Weekly Slapshot tonight at 9:30pm ET on BTR's Fantasy Sports Channel. I hope everyone can take a listen as we get into those fantasy hockey playoff questions few have the guts to answer. Thanks again for reading.


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Wednesday 13 January 1971
It was Wednesday, under the sign of Capricorn. The US president was Richard Nixon (Republican).
Famous people born on this day include Elmer Dessens in Hermosillo and John Mallory Asher.
In that special week of January people in US were listening to My Sweet Lord by George Harrison.
In UK Grandad by Clive Dunn was in the top 5 hits.
Vanishing Point, directed by Richard C. Sarafian, was one of the most viewed movies released in 1971
while Wheels by Arthur Haile was one of the best selling books.
On TV people were watching All in the Family.
If you liked videogames you were probably playing Galaxy Game or Star Trek.
But much more happened that day: find out below..
You can also have a look at the whole 1971 or at January 13 across the years.
Old Newspapers
Have a look at the old newspapers from 13 January 1971 and get them!
TV Series
Which were the most popular TV series released in the last 30 days ?
Which were the most popular movies released in the last 30 days ?
Find out your future
Get a FREE Numerology report based on the digits of 13 January 1971!
Wish him/her..
Historical Events
Which were the important events of 13 January 1971 ?
- In Sweden, Christmas ends on the 20th day, St. Knut's Day. Children celebrate a party throwing out the Christmas tree (julgransplundring).
Famous Birthdays:
- Elmer Dessens in Hermosillo: Mexico; pitcher (Pittsburgh Pirates).
- John Mallory Asher: American film actor/director.
- John Asher: American actor and director.
- Phil Whyman: English paranormal researcher, television personality, writer and musician.
Famous Deaths:
- Bernard "Heinz" Lammerding: German SS-General/contractor (Tulle), dies at age 65.
- Robert Still: English composer and educator (d. 1971).
- Soon closes at Ritz Theater NYC after 3 performances
Featured Contents
Would you like to write an original contribution on a topic related to this specific date and get featured on Takemeback.to ? Send us your proposal!
Music Charts
Which were the top hits in that special week of January 1971 ?
Top #10 songs in the USA
- George Harrison - My Sweet Lord
- Dawn - Knock Three Times
- The 5th Dimension - One Less Bell To Answer
- Santana - Black Magic Woman
- The Partridge Family - I Think I Love You
- Bee Gees - Lonely Days
- King Floyd - Groove Me
- The Supremes - Stoned Love
- Barbra Streisand - Stoney End
- Smokey Robinson - The Tears Of A Clown
Search For Your Ancestors
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...and if 13 January 1971 was your Birth Date then Join our Birthday Club!
Make this date unforgettable
Genealogy: find out your family heritage
Magazine Covers
What news were making the headlines those days in January 1971?
- Time: TIME Magazine Cover: Ali MacGraw -- Jan. 11, 1971
- SportsIllustrated: Sports Illustrated: no.8211
- Life: Composite The New Shape of America
Which were the most popular books released in the last weeks ?
Remember when
What videogames would you be playing back in the days ?


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Duty fraud: we need legislation to help stamp it out
With the Budget days away, I will illustrate the imbalance in importance of anti-duty fraud measures proposed by HMRC…
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Menashi's Boy
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A collection of short stories inspired by different cultures (Middle Eastern and European), and derived from different historical periods (World War I, World War II, the Cold War; and the present time). It casts a light on issues such as religious conflicts and social changes.
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Skip to comments.Arrest & Indictment Officially Announced (teen rapes and kills two girls, one his cousin)
Posted on 07/01/2004 8:05:57 PM PDT by Behind Liberal Lines
GENEVA NY--A 16 year old Geneva boy has officially been charged with murder, rape and arson in connection with the deaths of Monique McKoy and Ashley Vincent.
The charges against Lamon McKoy, a cousin of Monique, were made public this afternoon at the Ontario County courthouse in Canandaigua. Police say McKoy raped both girls and set fire to his cousin's apartment to cover up her murder. Ontario County DA Michael Tantillo says McKoy has also been charged with sexually assaulting two other girls.
The Geneva Police Department, the State Police and the Ontario County District Attorney announced the indictment and arrest of Lamon J. McKoy, age 16, of Geneva, NY for the murders of Ashley Nicole Vincent, age 14 and Elizabeth McKoy age 18. The two victims were also from Geneva, NY.
Ashley Vincent had left her Patterson Avenue home the afternoon of December 29, 2003 to visit a friend. She later telephoned her mother, Beth Marchenese, to say that she would be home for dinner, but never arrived. A 13 year old boy found Ashley's body on the afternoon of March 2, 2004, covered with roofing shingles behind a dumpster around the corner from her house. The Ontario County D.A. reported that Ashley was killed on the day she went missing
Elizabeth M. McKoy was found dead by Fire Officials on January 20, 2004 when they responded to reports of a blaze in the third floor apartment at 372 Exchange St. where she was living with her aunt, Lirhonda Singletary. Elizabeth's body was discovered in her bedroom where the fire was located.
The cause of death in both murders was ruled to be strangulation.
The arrest follows a 5 1/2 month long investigation by the Geneva Police Department with the assistance of the NY State Police. The State Police, at times, had 18 investigators assigned to the case.
Lamon McKoy was arraigned at the Ontario County Jail before Judge Reed and committed to the Ontario County Jail. Because McKoy was only 15 years old at the times of both murders he can only receive 30 years to Life as a maximum sentence, 15 years for each murder. There is no death penalty available for prosecuters to persue for any offender under the age of 18 in NY State.
Thank God. We wouldn't want to ruin this poor kid's life by denying him parole. And God forbid he should be eligible for the death penalty
Our justice system sucks!
My bet; porn.
Too close to home. Way too close. My daughter used to run cross country practice down the street where Ashley was killed. My computer guru's Dad owns the store, above which lived Monica (nobody called her Elizabeth). That's where the cover-up fire was. The police chief, whom I know well, was on Syracuse and Rochester TV tonight saying what I knew he would: Stuff like that just doesn't happen around here. The alleged perp was tossed out of the local schools and was in a restrictive group home. I have no idea why he was loose. God bless the innocent girls, and their grieving parents.
We had a guy (same town) who did get the death penalty. A judge vacated the sentence. NY only looks like it has the death penalty. I don't know of anyone who's actually had a date with Ol' Sparky.
Hope the girls in that area still are being careful just in case the alleged perp isn't the perp!!
My bet: very bad childhood, or some sort of biological brain abnormality.
He very well may have looked at pornography, even sick pornography, but that would have been caused by his being a sicko in the first place, the pr0n would not have turned him bad.
Plenty of kids look at pr0n without committing rapes and murders.
Too bad that we seldom here what these murdering perverts did in their pastime. . .what kind of music they favored; books read or magazines. . .or internet pastimes. . .or even what video game was their favorite etc. I really would like to know; would like to know more of what these people find their pleasure in.
Not to blame the above in any single sense of course; but would be nice to know just how 'off the mark' or on. . .they might have been re their private lives.
And just how off. . .or on the mark; we might be, should we make assumptions.
Porn is a reasonable assumption; it is surely corrosive in it's impact on young people. . .and old as well.
Just want to add again, that do not see these choices in any 'single' sense as causation for criminal behavior. . .but for the already behavior-challenged kid; there are a lot of 'bad' choices available.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


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text:
The city window displays current weather conditions for a particular city, with links to in-depth information from Wikipedia about that city, state or country. To display the city window, simply move your mouse over the globe until the name of the location you are interested pops up and click on it.
The EarthBrowser desktop application has a database of the 25,000 most populated cities from the Geonames.org service. Weather conditions and forecasts from CustomWeather.com are mapped to each location from the nearest station.
City window for Reykjavik, Iceland
The name of the selected city, its state or province and country is displayed at the top of the window. Click on any one of these names or the flag icon to go to a Wikipedia entry on that location.
The zoom slider on the right side of the city window enables you to customize the weather icon dataset. You can add a city and set the camera elevation at which the weather icon appears by clicking the button with a "+" or "o" label. If the current city is not in your list of cities to track, the "+" button will add it, the "o" button will let you set the zoom level. Once you click that button, the button will change to an "x" and your camera will center on the current city. To set the zoom, move the camera in or out to the desired level for the weather icon to appear and click the "x" button or just drag the earth off of that city. You can remove the city from the dataset by clicking on the "-" button. You can zoom in using the slider in the city window, the controls window or just using the mouse wheel.
The current weather, temperature and various other conditions are displayed above the 7 day weather forecast.
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Hey guys
I decided to make this quick reference guide for every MH & OH weapon type in the game. Every weapon pictured is Lvl 100 and at 25% Quality for the purpose of visualizing all their base stats. This guide may also prove useful for visualizing each weapon's default main & special skills.
Edited: now includes all Lvl 20 max quality weapons for PvP knowledge
I made this so I wouldn't have to keep checking up on this info. I hope it's helpful for you!
And the following diagram has been ever helpful to me in my journeys..Jasper Crystal guide for what each weapon will change into:
Good! Now I can throw away all empty weapons I have in Stash 1
Maybe use
"----------" for
That would be even more awesome!!
If you do it for ilvl 20 weapons also PvP players will cheer !!
I was thinking of doing that one too but I'll let @JesusSaves saves do it because he deserves the credit for making a guide like this one. Thanks for even more much needed guides. Keep up the good work @Everyone .
I'll work on the lvl 20 guide thanks for the encouragement actually I think the reason I most needed this guide was for build ideas cause I'm always forgetting what I can roll with Amber crystals and it helps to visualize the skills
Oh yeah that's another pro! Great one too! Only just realised lol. It's very accurate way of viewing said skills without looking in codex and getting items. Keep up the good work .
Great to have that, really! Please do edit though with "H" and "-" from the edit line to separate MH/OH/Class
Hope it's better - internet connection isn't the best. 🏽🏽
Same. I had to use 4G for 1 or 2 hours everyday and even then,.It's not satisfactory. When I do get wi-fi, it's not all that good unless it's midnight or if I'm alone at house. Well I'm in the UK though so it's alright but if you live in other place of the world, it gets even worse I guess.
So I should wait for a Gauntlet with Defiant in order to use Discordance or Sword/Staff would be good due to APS and CD?
Main problem is you need th 150% from Blast, that's why you should take Gauntlet. Other weapons might be faster, but you need to be a lot faster to make up for the loss of 50% damage. Pierce has 125% though, so you could look into that
Just calculate APS and compare it to your gain in damage from 50%/25% compared to 100% with the respective BWDs, but Gauntlet has high BWD so I think you can't beat Gauntlet
Edited now with iLvl 20 items and formatting
You Sir are great really really helpful, +1!!
Thanks sir for this wonderful list update . This should be seen by pretty much everyone and probably should be in the SHTT.
Summon @Skaul .


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NEW YORK -- The Brooklyn Nets are hosting the Denver Nuggets at Barclays Center on Tuesday night. The Nets are seeking their first winning streak of the season. Here's what we'll be watching for:
First time for everything: The Nets (5-12) have yet to string together consecutive victories this season. They are coming off a 97-88 win Saturday night in Memphis. Brooklyn is about to open up a stretch in which it plays nine of its next 12 games at home. If the Nets are going to turn around their season, now's the perfect time. Brooklyn is likely going to need big performances out of center Brook Lopez and shooting guard Joe Johnson on Tuesday night. Lopez is coming off a 21-point, 30-minute effort against Memphis on Saturday night, while Johnson is averaging nearly 20 points over his past seven games.
Injury report: The Nets will be without Paul Pierce (hand), Deron Williams (ankle), Andrei Kirilenko (back) and Jason Terry (knee). Alan Anderson will start in place of Pierce. Tyshawn Taylor will be the team's likely starter at point guard.
Nuggets of info: The Nuggets have won six in a row and rank third in pace. The Nets are 0-5 against top-10 teams in terms of pace this season (Timberwolves, Lakers, Rockets, Clippers and Magic). Infamous Nets-killer Nate Robinson, he of the 23-point fourth-quarter in Game 4 of the first round last season, is coming off a 23-point performance Sunday and has been playing really well of late. Denver's coach, Brian Shaw, was thought to be a favorite for the Brooklyn job until Jason Kidd came in and stole the show during an interview. The Nuggets rank second in the NBA in bench scoring (45.2 ppg). This appears to be a very tough matchup for Kidd and the Nets.


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Golf club notes
New Ross Seniors
We enjoyed a perfectly fine day on Thursday, albeit the south-westerly breeze was strong at times. The scoring was down as a consequence and most of the twelve teams out found the going rather tough, with only one team breaking the 90-point barrier.
They were Jimmy Furlong (12), Willie Naddy (20), Paul Laffan (21) and Tommy Furlong (24), emerging as the clear winners with a final total of 91 points. In second place on 88 points came Denis Kirwan (11), Shay Masterson (18), Michael Brennan (18) and Aidan O'Connor (19).
On a countback over the back nine (44/41), the team captained by Danny O'Leary (8), backed up by John F. Roche (17), Martin Forristal (21) and George Peters (24), was placed third with a grand total of 86 points. There were no nearest the pin prizes given as no tapes were put in position.
A warm welcome and best wishes was accorded to Pat Ryan who joined us out playing golf again after his recent operation. Our usual outing will take place next Thursday, October 1, and all players are asked to be on time.
Stewards for the draw board for October are Denis Kirwan, Colin Casey and Peter Goggin. Well done to two of our members, John Shalloe and Tom Kent, who were among the prize-winners at the recent Autumn Seniors Alliance outing in Dungarvan.
Our next big fixture is the return visit to Faithlegg on Tuesday, October 20. Names and cash will be taken on Thursday, October 9, as we will have to forward the list of players to Faithlegg in order for them to organise teams and prepare for the usual shotgun start seeing the big numbers participating every year.
Wednesday, September 23, sponsored by Hickey & Ryan Chartered Accountants: 1, Denise Bolger (17), 38 points (last nine); 2, Agnes Whelan (33), 38 points; 3, Margaret Murphy (23), 36 points; gross, Maria Burford, 21 points.
Upcoming competitions: Wednesday, September 30, 18-hole stableford sponsored by Murphy's Cash and Carry. Draw times: 10 to 10.15 a.m. and 2 to 2.30 p.m. A timesheet is also in operation.
Wednesday, October 7, 18-hole stableford sponsored by Burke's Pharmacy.
The nine-hole re-entry competition continues. Please enter as often as you like.
The fourth round of the Kathleen Pyne singles matchplay is now under way. Please have all matches completed by September 25.
The second round of the mixed foursomes has been extended until October 4. All matches should be completed by then.
There will be a presentation for all prizes to date on Wednesday, September 30, at 8 p.m. in the clubhouse. All prize-winners are asked to attend.
There was a good field for last weekend's open fourball sponsored by Audi Waterford which was played out in good conditions. The top spot went to Paul McGrath (5) and Eddie Morrissey (19) who amassed 43 points in the three-quarter handicap betterball format.
Visitors filled the other prize positions with Williamstown's John Kavanagh (13) and Enniscorthy's John Bail (10) taking second place with 42 points, and Tramore's Mick Sullivan (11) and Tony Whelan (15) finishing third on 41 points. Thank you to Audi Waterford for their welcome and generous support.
The final round of the Prim-Ed Publishing-sponsored Club Cup will take place next weekend. Ivan Croke (14) turned in a brilliant 64 to lead the event by three shots from John Hackett (12).
Three golfers - Jack Ryan (5), Eamon Dungan (5) and Jimmy St. Ledger (7) - share third place, with Robbie Farrell (scr.) the only other golfer to break 70, with a one under par round of 69.
John O'Connor (8) produced the only 70, whilst Declan Doyle (12) and Mark O'Mahony (7) are a further shot back on 71, but with a long way to go to catch the leader.
Congratulations to Jim Byrne and Tullogher's John Hartley who claimed the fourball matchplay title with a hard-fought win over the youthful pair of Alan Furness and Jamie Mackey.
The quarter-finals of the mixed foursomes matchplay are due for completion by October 4, with Eamon and Marie Therese Wall and Seamus Power and Denise Bolger already having secured their passage to the semi-finals.
Last week's Tuesday fourball was sponsored Patsy Moore, and John Whelan (15) and Liam Wall's (14) mark of 26 points was the best of the bunch. Seamus Phelan (13) and Matt Kavanagh (12) took category A with 24 points, the same score as recorded by the Category B winners, M.J. Cullen (17) and Richie Aylward (18).
Thank you to Patsy Moore for his continued and generous support. This week's event is sponsored by Jimmy Hanrahan.
The New Ross 3Ts (Turning the Tide on Suicide) team was in action in the regional qualifier at Dundrum House last week. The team, led out by club professional James Roche and accompanied by Ger Mackey, Paul Cleary and Rory Hussey, turned in a great performance to qualify for the national finals at the K Club on October 5.
Their score of 90 points was good enough for second place and only bettered on the countback by Mountain View. Well done to all involved!
The Find the Joker draw with a jackpot of €2,362 takes place this Tuesday, September 29, after the men's presentations.
Wexford People