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Posted on October 18, 2017
DNA methylation variants can arise spontaneously, they can be under genetic control or they can be induced by the environment. In plants, some DNA methylation variants are stable across many generations whereas other variants are very transient. A good understanding of the transgenerational dynamics of DNA methylation variants is essential to understand their impact on heritable traits and their effect on adaptation. Current insight in the transgenerational dynamics of DNA methylation is limited to very few model plant species, but it is predicted that these dynamics are not constant among different plants. For instance, plant reproduction mode can have a large effect because asexual reproduction bypasses some of the epigenetic resetting mechanisms that normally occur during sexual reproduction. Adaptive differences in transgenerational stability may also differ between species with different life spans or from habitats of different environmental predictability.
In this project, we aim to investigate differences in DNA methylation dynamics between species with different life history traits. In close collaboration with other bioinformaticians and biologists, a best-practice pipeline for the analysis of plant bisulfite data will be developed, benchmarked, and provided to be applied to the Next-Generation Sequencing (NGS) data generated in the frame of different EpiDiverse projects. In addition, novel algorithms will be devised and implemented to better detect DNA methylation variants and search for important methylation haplotypes to better understand the epigenetic regulation. The special constellation of working at a bioinformatics company in very strong cooperation with the chair of bioinformatics at the university offers the unique possibility of gaining benefits from both: The clearly structured style of the work in a company will help implementing novel ideas from academia in the light of recent publications, resulting in a strong focus and high productivity.
We seek a bright, highly motivated, and enthusiastic bioinformatician, or computer scientist with significant interest in solving biologically motivated questions. Excellent programming skills with knowledge of at least one of the following programming languages are mandatory: Python, R, or C/C++/C#. A strong background in Next-Generation Sequencing (NGS) and/or (epi)genetics data analyses are an advantage. A high standard of spoken and written English is required, as are good quantitative and analytical capabilities, excellent interpersonal and communication skills, and the ability to work independently as well as part of a team.
You may apply by providing a letter of motivation, a detailed CV and contact information of up to three references, all as a single pdf file!
Send the file by email:
If you have questions, you can contact email@example.com.
EpiDiverse - Epigenetic Diversity in Ecology - is a Marie Skłodowska-Curie Innovative Training Network aimed at the study of epigenetic variation in wild plant species. This network joins academic groups from ecology, molecular (epi)genetics and bioinformatics with life science companies to explore epigenetic mechanisms and their adaptive relevance in natural plant populations.
The cross-disciplinary research program investigates how epigenetic mechanisms, in interaction with environments and transposable elements, contribute to variation that is relevant for the adaptive capacity of plants. By applying epigenomic research tools to a selection of different wild plants (including long-lived trees, annual and asexually reproducing species) we investigate how epigenetic mechanisms as well as their ecological relevance differs between plant species. Understanding the epigenetic contribution to adaptive capacity will help to predict species responses to global warming and can open new directions for sustainable agriculture and crop breeding.
The EpiDiverse consortium will train 15 Early Stage Researchers to become expert eco-epigeneticists, equipping them with the interdisciplinary skills - molecular, (epi)genomic, ecological and bioinformatics - to successfully tackle this new research area. EpiDiverse training will emphasize empirical and informatics skills to become fluent and creative in extracting knowledge from big 'omics data in natural contexts.
EpiDiverse is funded by the EU Horizon 2020 programme and involves 12 partners from academia, non-profit organizations and industry located in the Netherlands, Germany, France, Spain, Czech Republic, Italy and Austria.
For further Information check the official website of EpiDiverse.
Posted on October 15, 2017
Our workshop "RNA-Seq Data Analysis Workshop: Quality Control, Read Mapping, Visualization and Downstream Analyses" in Leipzig last week was a full success. Our three trainers gave the 20 participants from 9 different countries (Norway, Germany, China, USA, UK, Czech Republic, Belgium, Netherlands, Qatar) an introduction on how to work with linux and how to analyze RNA-Seq data correctly. The gained knowledge will allow the researchers to start their own analyses and it will help them to discuss their bioinformatics problems or questions with bioinformaticians on an almost equal level.
DNA Methylation Data Analysis Workshop: How to use bisulfite-treated sequencing to study DNA methylation
Next-Generation Sequencing Data Analysis: A Practical Introduction
RNA-Seq Data Analysis Workshop: Quality Control, Read Mapping, Visualization and Downstream Analyses
Posted on September 16, 2017
Our 1st Berlin Summer School in NGS Data Analysis in Berlin last week was a full success. Our four trainers gave the 30 participants from 16 different countries (China, Germany, Poland, Austria, France, Belgium, Czech Republic, Denmark, United Kingdom, Norway, Switzerland, Slovenia, Netherlands, Japan, Réunion and Sweden) an introduction on how to work with linux and how to analyze DNA-Seq/RNA-Seq data correctly. The gained knowledge will allow the researchers to start their own analyses and it will help them to discuss their bioinformatics problems or questions with bioinformaticians on an almost equal level.
Metagenomics Analysis with MEGAN6
Next-Generation Sequencing Data Analysis: A Practical Introduction
Posted on August 30, 2017
You may have already heard of ecSeq Bioinformatics' cooperation with Seamless NGS, a biomedical software manufacturer and developer of tailored NGS solutions. We are pleased to inform you that last month there has been a merger between the two companies.
Seamless NGS has developed a unique portfolio of cutting-edge NGS software solutions which are already used in diagnostic laboratories and research facilities. They specialised on high-performance analyses of DNA, RNA and epigenetic markers for different diseases such as cancer.
We have joined forces with Seamless NGS to offer you a more complete portfolio for your NGS profiling. It is our mission to provide you with the best bioinformatics technologies and we believe we can create significant benefits for you in terms of convenience, cost-efficiency, and quality of results.
We are dedicated to maintaining and increasing the quality of innovation, support and service you expect from ecSeq Bioinformatics and Seamless NGS. We look forward to providing you with the most complete and advanced bioinformatics solutions for your NGS experiment.
Posted on July 28, 2017
Great article about ecSeq Bioinformatics's work and vision in the current issue of 'Healthcare Journal of Baton Rouge'. Thanks to Dr. Claudia S. Copeland (LinkedIn Profile) for this understandable article about a very complex topic
Read Flipping Book Version
Read PDF Version
Posted on June 30, 2017
Our workshop "Next-Generation Sequencing Data Analysis: A Practical Introduction" in Frankfurt this week was a full success. Our two trainers gave the 18 participants from 7 different countries (Germany, Croatia, South Korea, Netherlands, Israel, Czech Republik and Finland) an introduction on how to work with linux and how to handle RNA-Seq and DNA-Seq data correctly. The gained knowledge will allow the researchers to start their own analyses and it will help them to discuss their bioinformatics problems or questions with bioinformaticians on an almost equal level.
1st Berlin Summer School in NGS Data Analysis
RNA-Seq Data Analysis Workshop
Metagenomics Analysis with MEGAN6
Next-Generation Sequencing Data Analysis: A Practical Introduction
Posted on June 29, 2017
Due to an extraordinary run on our "1st Berlin Summer School" in September in Berlin and an astounding long waiting list, we decided to offer an additional RNA-Seq course with almost the same topics in October in Leipzig.
RNA-Seq Data Analysis Workshop
Posted on May 11, 2017
Our workshop "Next-Generation Sequencing Data Analysis: A Practical Introduction" in Munich last week was a full success. Our two trainers gave the 20 participants from 8 different countries (Germany, USA, Saudi Arabia, UK, Romania, Belgium, Slovenia and Turkey) an introduction on how to work with linux and how to analyze RNA-Seq and DNA-Seq data correctly. The gained knowledge will allow the researchers to start their own analyses and it will help them to discuss their bioinformatics problems or questions with bioinformaticians on an almost equal level.
Next-Generation Sequencing Data Analysis: A Practical Introduction
1st Berlin Summer School in NGS Data Analysis
Metagenomics Analysis with MEGAN6
Next-Generation Sequencing Data Analysis: A Practical Introduction
Posted on April 15, 2017
Today marks 5 years exactly that ecSeq Bioinformatics entered the highly competitive and innovative world of life sciences. In the last 5 years we have learned a lot, shared a lot, taught a lot and built a lot. We have seen substantial growth take place with the sequencing technology. We truly believe this technology and industry will develop rapidly in the coming years.
We have had the pleasure of working with some amazing clients, building great solutions and relationships that extend well beyond typical client/contractor engagements. We also want to send a special shout out to our sequencing partners who give us a much needed helping hand to deliver high quality solutions for our clients.
We have some exciting things in the works for the remainder of the year, so stay tuned. As we continue our journey, we are excited to see what the next 5 years and beyond will bring.
Posted on March 25, 2017
Our workshop "RNA-Seq Data Analysis Workshop: Quality Control, Read Mapping, Visualization and Downstream Analyses" in Berlin last week was a full success. Our three trainers gave the 25 participants from 11 different countries (Germany, USA, Qatar, Netherlands, Hungary, Belgium, China, United Kingdom, Poland, Croatia and Italy) an introduction on how to work with linux and how to analyze RNA-Seq data correctly. The gained knowledge will allow the researchers to start their own analyses and it will help them to discuss their bioinformatics problems or questions with bioinformaticians on an almost equal level.
Next-Generation Sequencing Data Analysis: A Practical Introduction
1st Berlin Summer School in NGS Data Analysis
Next-Generation Sequencing Data Analysis: A Practical Introduction
Posted on February 08, 2017
Rubber from dandelions
In recent years the Russian dandelion Taraxacum koksaghyz, a previously neglected wild plant, has been investigated to be re-introduced as a valuable rubber crop that grows in moderate climates, like in Germany. The milky sap of the dandelion shows similarities to that of the rubber tree, and most importantly contains caoutchouc, the raw material for rubber production.
Together with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME, ESKUSA GmbH and hortilab, ecSeq GmbH will generate a high-resolution genetic map of Russian dandelion.
Dr. Christian Schulze Gronover (Fraunhofer IME) received the 2015 Joseph von Fraunhofer Prize for his work on the Russian dandelion and its application as a source of natural rubber. He is the coordinator of the project, which is funded by the German Federal Ministry of Education and Research (BMBF).
Dr. Fred Eickmeyer (ESKUSA GmbH) specialized on breeding of dandelion. He wants to optimize and establish Russian dandelion to an alternative raw material for natural rubber.
Posted on February 01, 2017
Today we signed a cooperation agreement with Prof. Dr. Emmanuelle Charpentier.
We are looking forward to this great partnership.
Prof. Dr. Emmanuelle Charpentier is best known for her role in deciphering the molecular mechanisms of the bacterial CRISPR-Cas9 immune system and repurposing it into a tool for genome editing. In particular she uncovered the mechanism beyond the maturation of non-coding RNA key for the CRISPR-Cas9 function. In collaboration with Jennifer Doudna's laboratory, Charpentier's laboratory showed that Cas9 could be used to make cuts in any DNA sequence desired. The method they developed involved the combination of Cas9 with easily created synthetic "guide RNA" molecules. Researchers worldwide have employed this method successfully to edit the DNA sequences of plants, animals, and laboratory cell lines.
Posted on January 27, 2017
Dr. Gero Doose is head of research and development at ecSeq GmbH. He developed RNA folding and protein solubility prediction algorithms before he started working with high-throughput sequencing data. Gero implemented detection pipelines for circularized and trans-spliced transcripts. As an expert for split-read alignment analysis, he also developed a sophisticated method to detect differential alternative splicing.
The transcription factor MYC plays a key role in carcinogenesis. Together with scientists around Dr. Ingram Iaccarino (Christian Albrechts University) and Dr. Dr. Steve Hoffmann (University of Leipzig), Dr. Doose discovered a long non-coding RNA that is able to modulate MYC's transcriptional network. This finding therefore has the potential to open new therapeutic opportunities for MYC associated cancers. The results were published in the renowned journal "Proceeding of the National Academy of Science of the United States of America" (PNAS).
Doose G, Haake A, Bernhart SH, López C, Duggimpudi S, Wojciech F, Bergmann AK, Borkhardt A, Burkhardt B, Claviez A, Dimitrova L, Haas S, Hoell JI, Hummel M, Karsch D, Klapper W, Kleo K, Kretzmer H, Kreuz M, Küppers R, Lawerenz C, Lenze D, Loeffler M, Mantovani-Löffler L, Möller P, Ott G, Richter J, Rohde M, Rosenstiel P, Rosenwald A, Schilhabel M, Schneider M, Scholz I, Stilgenbauer S, Stunnenberg HG, Szczepanowski M, Trümper L, Weniger MA; ICGC MMML-Seq Consortium, Hoffmann S, Siebert R, Iaccarino I: 'MINCR is a MYC-induced lncRNA able to modulate MYCs transcriptional network in Burkitt lymphoma cells'. PNAS, 112(38):E5261-70. (2015)
Posted on December 13, 2016
Our workshop "Next-Generation Sequencing Data Analysis: A Practical Introduction" in Munich last week was a full success. Our two trainers gave the twenty participants from eight different countries an introduction on how to work with linux and how to analyze NGS data correctly. The gained knowledge will allow the researchers to start their own analyses and it will help them to discuss their bioinformatics problems or questions with bioinformaticians on an almost equal level.
RNA-Seq Data Analysis Workshop
Please find detailed information and a course program on the workshop's page.
Posted on September 23, 2016
bionection is an international event for technology transfer in life sciences. Thus, participants from industry and academia will present and discuss their latest inventions in this hot research field. The venerable Leopoldina provides an amazing scene for inspiring discussions, extraordinary thoughts and exchange of innovative ideas.
Besides Thermo Fischer and Thyssenkrupp Industrial Solutions, ecSeq's CEO Dr. David Langenberger will be one of the three keynote speakers at the event. On the second day of the conference, David will talk about today's challenges in NGS bioinformatics. Our business area, NGS bioinformatics, fits very well into the overall aim of bionection, where the latest progress in medical and bio-technologies, as well as current questions in life sciences will be presented.
The German National Academy of Sciences was founded in 1652. Since then it is "dedicated to the advancement of science for the benefit of humankind and to the goal of shaping a better future". ecSeq GmbH is honored to speak in such history-charged halls in Halle (Saale).
Posted on September 15, 2016
Great News:
The two trainers of our upcoming epigenomics workshop 'DNA Methylation Data Analysis' got their research work published in Nature Genetics.
Dr. Helene Kretzmer and Dr. Christian Otto identified differentially methylated regions in Burkitt and follicular lymphoma using exactly the bisulfite sequencing data analysis method that they will teach in the workshop.
22-25 November 2016 in Leipzig, Germany: DNA Methylation Data Analysis
Kretzmer et al.: 'DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control', Nature Genetics (2015)
|Dr. Helene Kretzmer (University Leipzig) is working on DNA methylation analyses using NGS since 2011. She is responsible for the bioinformatics analysis of the MMML-Seq study of the International Cancer Genome Consortium (ICGC).
|Dr. Christian Otto (CCR Bio-IT) is one of the developers of bisulfite read mapping tool segemehl and is an expert on implementing efficient algorithms for NGS data analysis.
Posted on July 28, 2016
To address this unavoidable need, we established an extensive network of outstanding scientists, covering all research fields relevant to NGS. Together with a project-specific expert panel ('think tank'), we will analyze your data in a scientifically proven manner to provide you with meaningful, knowledge-driven results.
13 Professors
31 PhDs
3 PhD students
scientifically sound analyses
approved and interpreted by experts
timely delivery
Go through the complete list of scientists and check the extraordinary experts in our expert-network:
Please also check our upcoming workshops in fall 2016:
Posted on July 06, 2016
Our workshop "Next-Generation Sequencing Data Analysis: A Practical Introduction" in Munich two weeks ago was a full success. Our two trainers gave the twenty participants from nine different countries an introduction on how to work with linux and how to analyze NGS data correctly. The gained knowledge will allow the researchers to start their own analyses and it will help them to discuss their bioinformatics problems or questions with bioinformaticians on an almost equal level.
For everyone who was not able to attend we will organize a second workshop in December 2016. It will be at the same location in Munich and it will cover the exact same topics. Perfect for beginners.
Next-Generation Sequencing Data Analysis: A Practical Introduction
Please find detailed information and a course program on the workshop's page.
Besides this introduction course we have planned three more workshops in fall 2016:
Posted on May 04, 2016
We recently received a visit by Tobias Hoffmann, a journalist from the German "Laborjournal" (German for lab journal). In its latest issue (from May 2nd, 2016) ecSeq GmbH and its founders, Dr. David Langenberger and Dr. Mario Fasold, are portrayed in a double-page article.
The article talks about our two founders, how they gained their doctorates from professor Stadler in Leipzig and their way to ecSeq GmbH. One of our business areas are workshops which train the participants how to analyze NGS data. We want to impart a discretionary competence as well as evaluation skills with the courses. Public workshops take place in Munich, Berlin, Prague or Oxford with about one third of the participants having an industrial (non-academic) background. This knowledge is important because nowadays every research application contains NGS analyzes.
Secondly, Hoffmann introduces our network of 45 highly skilled NGS experts to the readers. During project consulting ecSeq GmbH accompanies NGS projects which require complex bioinformatics solutions. Customers can book nearly everything: the analyses, the software or the complete planning of an experiment. All NGS experts are working in the background together with ecSeq GmbH.
Of course, the author asks the follow up question: 'Why should customers approach ecSeq and not the experts directly?' The answer is pretty simple: 'Because academic researchers with their reservations are often not very open-minded about inquiries from companies.' With ecSeq GmbH as intermediary, a trustful and well-managed collaboration is possible. This separation of industry and academia is very important for both, the companies and the researchers in our network.
We thank the "Laborjournal" for this great introduction of our company! You can get your free copy of the "Laborjournal" at universities and research facilities or on their website.
Posted on April 26, 2016
At the Life Sciences Career Day Dresden students from biology, biotechnology, biochemistry, medicine & pharmacy can get an impression about how their future could look like. We at ecSeq GmbH are very honored to represent the career path of a start-up company in the field of life sciences and to embold young scientists to realize their own ideas!
Deciding where to go after university is by far not trivial and has to be well thought out. Researchers have to realize that an academic career with the aim to get a professorship or the industrial path as an employee are not the only possibilities. We will explain and picture an interesting, but challenging middle course, the entrepreneurship. During our presentation we will tell the exciting story about starting our own company. We will describe how to turn the dream of a business into reality, talk about the initial period and finally, demonstrate how our daily work routine looks like. Afterwards, all upcoming questions will be answered.
The Life Science Career Day takes place on June 3rd, 2016 at the "Hörsaalzentrum" in Dresden, Germany.
It is organized by the biotechnology students initiative btS. We are looking forward to meet enthusiastic students who would like to discuss bioinformatics and its future with us.
These questions will be answered:
Posted on April 01, 2016
It is always important to have a good network of partner corporations and institutes to learn from each other. To this end, ecSeq GmbH is now a member of biosaxony, the cluster of the biotechnology and life sciences sector in Saxony. The organization hosts projects with participating scientists and companies, provides its members useful services and know-how, has the aim to develop the branch and strengthens the business location Saxony. It combines members from areas of economy, science and politics like young start ups, universities, research institutes, municipalities as well as large-scale enterprises.
We are looking forward to an interesting exchange with the Saxon biotechnology network!
Posted on March 21, 2016
We are very pleased to introduce Dr. Martin Smith as a member of our NGS Expert Network.
Dr. Martin Smith is a computational biologist with a strong background in biology. As a child he grew up in Canada and he always dreamt of becoming a biologist. He majored as an undergraduate in microbiology and immunology at the University of Montreal, but he quickly realised this wasn't his field. Switching to the emerging field of bioinformatics was an enthusiastic yet challenging decision for him, as it required rewiring his brain around abstract informatics concepts and discrete mathematics.
To this day, he is very passionate about bioinformatics and would recommend a cross-disciplinary career path to anyone. He has worked in 5 different cities across 3 different continents, namely Montreal (University of Montreal); Quebec City (Infectious Disease Research Centre—CHUL); Brisbane (Institute for Molecular Bioscience); Leipzig (Interdisciplinary Center for Bioinformatics); and Sydney (Garvan). He received his doctorate in Genomics and Computational Biology from the University of Queensland in 2012. His doctor's thesis was supervised by Prof. Dr. John Mattick and Prof. Dr. Peter F. Stadler.
His research revolves around characterising the "regulome", i.e. the biological mechanisms that control how genes are activated and repressed. He is particularly interested in how non-protein coding regions of the genome can regulate gene expression at the level of RNA.
Posted on February 29, 2016
Around the turn of the year (2015/2016), we asked the question:
What courses would you like us to prepare for 2016?
We analyzed all votes (~200 single votes) and below you can find the result of the survey. Based on your voting, we put together the following workshop agenda for 2016:
June 29 - July 1, 2016 in Munich, Germany
Next-Generation Sequencing Data Analysis: A Practical Introduction
September 5 - 9, 2016 in Prague, Czech Republic
2nd Prague Summer School - Next-Gen Seq Data Analysis
September 21 - 23, 2016 in Berlin, Germany
microRNA Analysis Using Next-Generation Sequencing
September 21 - 23, 2016 in Berlin, Germany
DNA Variant Calling Workshop
September 28 - 30, 2016 in Leipzig, Germany
De Novo Transcriptome Analysis - Assembly and Differential Gene Expression
November 22 - 25, 2016 in Leipzig, Germany
Epigenetics Workshop - DNA Methylation Data Analysis
In February we already covered the following courses:
February 1-5, 2016 in Leipzig, Germany
A Beginner's Guide to RNA-Seq Data Analysis
February 8-10, 2016 in Leipzig, Germany
De Novo Genome Assembly Using Next-Generation Sequencing Data
Posted on February 25, 2016
We are very pleased to introduce Dr. Alexander Donath as a member of our NGS Expert Network.
Dr. Alexander Donath is head of section for Computational Genomics at the Zoological Research Museum Alexander Koenig. Since 2011 he is working on NGS data analysis and de novo assembly of non-model organisms. He is involved in a number of large-scale transcriptome and genome research projects, for example 1KITE and i5k.
'... The study authors, who are part of an international consortium working on the 1K Insect Transcriptome Evolution (1KITE) project, began their work in 2011 in hopes of using newly available sequencing technology to clarify insect relationships previously only investigated using morphological evidence or smaller molecular datasets. They sequenced transcriptomes from 103 insect species distributed across all living insect orders. They also drew data from previously published whole-genome sequences of 14 arthropod species, as well as from transcriptomes of 27 additional species. They then narrowed down their genetic data to 1,478 protein-coding genes that are present in all of the species analyzed. ...'
from TheScientist
Posted on January 19, 2016
We are very pleased to introduce Prof. Dr. Manja Marz as a member of our NGS Expert Network.
Prof. Dr. Manja Marz studied biology and computer science at the University of Leipzig, and received her Ph.D. in bioinformatics from the University of Leipzig in 2009. After leading a Group at the Philipss-University of Marburg and Junior-Professorship at the Friedrich-Schiller-University Jena, she got two calls for professorships at University of Lübeck and Friedrich Schiller University Jena in 2014. Since 2015 she holds a full professorship at Friedrich Schiller University Jena. She is also Founding member of MSCJ (Michael Stifel Zentrum Jena for Data-Driven and Simulation Science), Board member of ZAJ (Aging Research Center Jena), Founding and board member of FIFI (Fördervereinverein des Instituts für Informatik) and Group leader at Leibniz Institute for Age Research – Fritz Lipmann Institute.
Her research interest include High Throughput Sequencing Analysis, Comparative Genomics, Identification and Annotation of Non-coding RNAs, Bioinformatic Analysis and System Biology of Viruses, Coevolution of Proteins and RNAs, Algorithmic Bioinformatics and Phylogenetic Analysis.
Posted on December 30, 2015
With 2015 coming to an end we can't help but feel a little nostalgic and look back at what the past twelve months have brought us. We couldn't be happier with what we do and we have all of you, our loyal customers to thank for our success.
During the past 360 or so days, we have been hard at work to train you in NGS data analysis and analyze your NGS data. We are extremely thankful for all the support and word-of-mouth advertising for our services.
We are all set for 2016 and can't wait to see what the New Year is going to bring to the NGS world.
Wishing you a Happy Holiday and a joyful New Year.
Best wishes from the complete team at ecSeq GmbH.
Posted on December 10, 2015
This year, again, we offered several hands-on bioinformatics NGS workshops. We widened our range and went to different venues across Europe in order to make our service available to more and more interested researchers. Besides basic NGS introduction courses, we always try to extend our portfolio to cover further NGS applications.
Posted on November 04, 2015
We are very pleased to introduce Prof. Dr. Ivo Hofacker as a member of our NGS Expert Network.
Since 2010 Prof. Dr. Ivo Hofacker holds a double professorship at the faculties of Chemistry and Computer Science. He is currently head of the Research Group Bioinformatics and Computational Biology.
His scientific interests fit mostly under the computational biology umbrella. Much of his work focuses on RNA Bioinformatics, the most visible part perhaps being the Vienna RNA Package for prediction and comparison of RNA secondary structures, which he and his coworkers have developed for over 15 years.
Posted on November 02, 2015
Check out our Facebook page and learn more about our products, our hands-on workshops, our research topics and our expertise in NGS data analysis. Share your ideas and stay conntected.
In our Facebook group 'Next-Generation Sequencing Data Analysis' you will learn about upcoming events, open jobs, and interesting information about the rapidly growing field of Next-Generation Sequencing. So connect with us and discover the world of ecSeq Bioinformatics.
Posted on October 30, 2015
We are very pleased to introduce Prof. Dr. Rolf Backofen as a member of our NGS Expert Network.
Prof. Dr. Rolf Backofen studied computer science at the University of Erlangen, and received his Ph.D. in computer science from the University of Saarland in December 1994, where he worked at the German Research Center for Artificial Intelligence (DFKI). He received his habilitation from the University Munich (LMU) in February 2000. He was holding the chair for bioinformatics at the University of Jena from November 2001 till June 2005. In 2004 he became the holder of the chair for Bioinformatics at the University of Freiburg, Institute of Computer Science.
His research interest include constraint programming, structure prediction in simplified protein models, investigation of protein energy landscapes, detection of RNA sequence/structure motifs, prediction and evaluation of alternative splice forms, description and detection of regulatory sequences.
Posted on October 09, 2015
Great News:
The two trainers of our upcoming epigenomics workshop 'DNA Methylation Data Analysis' got their research work published in Nature Genetics.
Helene Kretzmer and Dr. Christian Otto identified differentially methylated regions in Burkitt and follicular lymphoma using exactly the bisulfite sequencing data analysis method that they will teach in the workshop.
15-17 December 2015 in Leipzig, Germany: DNA Methylation Data Analysis
Kretzmer et al.: 'DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control', Nature Genetics (2015)
|Helene Kretzmer (University Leipzig) is working on DNA methylation analyses using NGS since 2011. She is responsible for the bioinformatics analysis of the MMML-Seq study of the International Cancer Genome Consortium (ICGC).
|Dr. Christian Otto (CCR Bio-IT) is one of the developers of bisulfite read mapping tool segemehl and is an expert on implementing efficient algorithms for NGS data analysis.
Posted on September 16, 2015
Nobody can be an expert in everything. However, biomedical projects increasingly demand expert knowledge in more than a single field. In fact, up-to-date expert knowledge is key to generating impactful biological insights.
To this end, we established an extensive network of outstanding scientists, covering various research fields relevant to NGS. The idea is that, together with the customer, we assemble a panel of experts that is able to develop an optimal strategy for the specific challenges of the project (see our white paper).
Our bioinformatics team can then rapidly implement a software solutions since we already have a library of analysis modules for many NGS applications.
Get more information here.
Posted on April 07, 2015
We are now able to offer end-to-end analysis solutions for the NGS applications RNA-Seq, small-RNA-Seq, and DNA-seq. This includes essential steps from sample preparation and sequencing to extensive bioinformatics data analysis. This is enabled by our partnership with AllGenetics, a biotech company specialized in NGS research projects. Our partnership with AllGenetics ensures that projects can be completed smoothely and effectively from project design to data analysis.
Posted on March 19, 2015
We happily announce that the next NGS workshop will take place September 7-11 in Prague. The course entitled 'PRAGUE SUMMER SCHOOL - NEXT-GEN SEQ DATA ANALYSIS' spans a whole week and is organized by SEQme in cooperation with ecSeq Bioinformatics. The workshop specifically addresses the needs of beginners in the field of NGS bioinformatics.
Please click here to visit the workshop website.
Posted on February 26, 2015
The Illumina User Group Meeting (UGM) Central Europa is taking place on March 10-11 at the EMBL in Heidelberg, Germany. Dr. Mario Fasold will present new possibilities for bioinformatic analysis of RNA-seq data and also be available for discussions on the afternoon of March 11. Please contact us if you would like to schedule a meeting there.
Posted on November 27, 2014
In March 2015 our NGS data analysis are again taking place in Leipzig. The workshop has been redesigned and adapted to the needs of beginners in the field of NGS bioinformatics. There are now two optional courses on RNA-seq data analysis (model and non-model organisms). Building on the knowledge covered in the main course allows us to cover the many relvant aspects of downstream RNA-seq analyses.
Link to the workshop page.
Posted on October 29, 2014
In this intensive course, students will learn how to survive in a Linux environment, get hands-on experience in two widely used programming languages (Perl and R), and statistical data analysis. The classes will be given by experts in the field and consist of lectures and exercises with the computer. The aim of the course is to provide the students with the necessary background and skills to perform computational analyses with a focus on solving research questions related to genomics and evolution. The philosophy of the course will be "learning by doing", which means that the computational skills will be taught using examples and real data from evolutionary biology for the exercises. During the course, students will also propose projects of their own interest and perform them as final projects in small groups under the supervision of a teaching assistant. This November school the school goes to Colombia. It is open for students from all countries, but specially, from the Americas. It is mainly targeted toward PhD students, MSc students and Postdocs of evolutionary biology or related research fields with no or little programming experience who want to become proficient in computational evolutionary biology in a couple of weeks.
Link to the workshop page.
Posted on October 27, 2014
The purpose of this workshop is to get a deeper understanding in Next-Generation Sequencing (NGS) with a special focus on bioinformatics issues. Advantages and disadvantages of current sequencing technologies and their implications on data analysis will be discovered. The participants will be trained on understanding their own HTS data, finding potential problems/errors therein and finally performing their own analyses using open source tools. In the course we will use a RNA-seq dataset from the current market leader, Illumina.
Link to the workshop page.
Posted on October 08, 2014
Sarah A. Munro, Steven P. Lund, P. Scott Pine, Hans Binder, Djork-Arné Clevert, Ana Conesa, Joaquin Dopazo, Mario Fasold, Sepp Hochreiter, Huixiao Hong, Nadereh Jafari, David P. Kreil, Paweł P. Łabaj, Sheng Li, Yang Liao, Simon M. Lin, Joseph Meehan, Christopher E. Mason, Javier Santoyo-Lopez, Robert A. Setterquist, Leming Shi, Wei Shi, Gordon K. Smyth, Nancy Stralis-Pavese, Zhenqiang Su, Weida Tong, Charles Wang, Jian Wang, Joshua Xu, Zhan Ye, Yong Yang, Ying Yu & Marc Salit: 'Assessing technical performance in differential gene expression experiments with external spike-in RNA control ratio mixtures, Nature Communications, 5:5125.
Posted on September 10, 2014
Su Z, Labaj PP, Li S, Thierry-Mieg J, Thierry-Mieg D, Shi W, Wang C, Schroth GP, Setterquist RA, Thompson JF, Jones WD, Xiao W, Xu W, Jensen RV, Kelly R, Xu J, Conesa A, Furlanello C, Gao H, Hong H, Jafari N, Letovsky S, Liao Y, Lu F, Oakeley EJ, Peng Z, Praul CA, Santoyo-Lopez J, Scherer A, Shi T, Smyth GK, Staedtler F, Sykacek P, Tan XX, Thompson EA, Vandesompele J, Wang MD, Wang J, Wolfinger RD, Zavadil J, Auerbach SS, Bao W, Binder H, Blomquist T, Brilliant MH, Bushel PR, Cai W, Catalano JG, Chang CW, Chen T, Chen G, Chen R, Chierici M, Chu TM, Clevert DA, Deng Y, Derti A, Devanarayan V, Dong Z, Dopazo J, Du T, Fang H, Fang Y, Fasold M, Fernandez A, Fischer M, Furió-Tari P, Fuscoe JC, Caimet F, Gaj S, Gandara J, Gao H, Ge W, Gondo Y, Gong B, Gong M, Gong Z, Green B, Guo C, Guo L, Guo LW, Hadfield J, Hellemans J, Hochreiter S, Jia M, Jian M, Johnson CD, Kay S, Kleinjans J, Lababidi S, Levy S, Li QZ, Li L, Li L, Li P, Li Y, Li H, Li J, Li S, Lin SM, López FJ, Lu X, Luo H, Ma X, Meehan J, Megherbi DB, Mei N, Mu B, Ning B, Pandey A, Pérez-Florido J, Perkins RG, Peters R, Phan JH, Pirooznia M, Qian F, Qing T, Rainbow L, Rocca-Serra P, Sambourg L, Sansone SA, Schwartz S, Shah R, Shen J, Smith TM, Stegle O, Stralis-Pavese N, Stupka E, Suzuki Y, Szkotnicki LT, Tinning M, Tu B, van Delft J, Vela-Boza A, Venturini E, Walker SJ, Wan L, Wang W, Wang J, Wang J, Wieben ED, Willey JC, Wu PY, Xuan J, Yang Y, Ye Z, Yin Y, Yu Y, Yuan YC, Zhang J, Zhang KK, Zhang W, Zhang W, Zhang Y, Zhao C, Zheng Y, Zhou Y, Zumbo P, Tong W, Kreil DP, Mason CE, Shi L.: 'A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium', Nature Biotechnology, 32(9):903-914.
Posted on July 30, 2014
We are looking for a student with background in web development. The project can be undertaken as part of an internship, as student employee or as part of a bachelor/master/diploma thesis. This project is a collaboration with the bioinformatics group of Prof. Peter F. Stadler at the University of Leipzig.
Find more information in our job flyer (only in German).
Posted on May 09, 2014
We are very pleased to announce that Prof. Dr. Peter F. Stadler has joined our Scientific Advisory Board.
Prof. Dr. Peter F. Stadler received his Ph.D. in Chemistry from the University of Vienna in 1990 following studies in chemistry, mathematics, physics and astronomy. After a PostDoc at the Max Planck Institute for Biophysical Chemistry in Goettingen he returned to Vienna to work in the area to theoretical biochemistry. Since 1994 he is External Professor at the Santa Fe Institute, a research center focussed on Complex Systems. In 2002 he moved to the University of Leipzig as Full Professor of Bioinformatics. Furthermore, he is Senior Scientific Advisor at the RNomics Group at the Fraunhofer Institute for Cell Therapy and Immunology (IZI) in Leipzig, Principal Investigator at the Center for non-coding RNA in Technology and Health (RTH) in Copenhagen, External Scientific Member of the Max Planck Society affiliated with the MPI for Mathematics in the Sciences in Leipzig, Guest Lecturer at the Institute for Theoretical Chemistry of the University of Vienna and Corresponding Member Abroad of the Austrian Academy of Sciences. He published more than 400 scientific papers and articles and is Member of the Editorial Boards of seven scientific journals.
Posted on April 07, 2014
We're celebrating the 2nd Anniversary of ecSeq Bioinformatics and want to thank all clients and workshop participants for the awesome two years. You placed confidence and trust in us to provide a needed service - we did not take this responsibility lightly. We would like to express gratitude to our partners and our great team.
Posted on March 28, 2014
Do you think your skills in sequencing data analysis could need some improvement? Then our NGS workshop series taking place in October 2014 might be interesting for you. As usual, these hands-on workshops have a strong focus on practical experience meaning that you analyze typical NGS datasets. Our trainers will directly interact with you and give valuable feedback.
Our workshop series 2014 will consist of four separate courses:
For beginners, we have the RNA-seq Bioinformatics: A Practical Introduction course which will cover all the basics required for NGS analysis like file formats, quality control, read processing and read alignment, all based on an example RNA-seq dataset.
We are very happy that we could convince Dr. Michael Hackenberg, the developer of one of the most-used microRNA gene prediction tools for small RNA-seq data (miRanalyzer) to join us for our microRNA workshop. This course titled microRNA Analysis Using High-Throughput Sequencing will cover the essential steps of small RNA-seq analysis from microRNA prediction to extensive downstream analyses.
We also have a workshop on DNA Methylation Analysi where Helene Kretzschmer will show you how she took care of her data in the MMML-Seq study of the International Cancer Genome Consortium (ICGC).
Lastly, there is the workshop Discovering standard and non-standard RNA transcripts where Gero Doose will train you on advanced methods of transcriptome analysis. Gero has a strong background in transcriptome analysis, finding different isoforms, fusion-transcripts or circularized RNAs.
There is an early-bird discount which applies until end of april.
Posted on March 10, 2014
At March 27, the presentation 'Inferring non-coding RNAs from RNA-Seq Data' will be held in Bonn, Germany.
Posted on March 05, 2014
At March 22, the presentation 'Analysis of high-throughput sequencing data' will be given at the 3rd Programming for Evolutionary Biology Course in Leipzig, Germany.
Posted on February 10, 2014
Hoffmann S, Otto C, Doose G, Tanzer A, Langenberger D, Christ S, Kunz M, Holdt L, Teupser D, Hackermüeller J, Stadler PF: 'A multi-split mapping algorithm for circular RNA, splicing, trans-splicing, and fusion detection', Genome Biology, 15:R34, doi:10.1186/gb-2014-15-2-r34
Posted on January 28, 2014
Hertel J, Langenberger D, Stadler PF: 'Computational prediction of microRNA genes' in J. Gorodkin, W.L. Ruzzo, (eds).: RNA Sequence, Structure and Function: Computational and Bioinformatic Methods. Volume 1097 of Methods in Molecular Biology, Humana Press, New York.
Posted on December 05, 2013
Hezaveh K, Bernhart S, Hoffmann S, Langenberger D, Schlesner M, Stadler PF, Binder V, Lenze D, Siebert R, Hummel M, Borkhardt A: 'In-Depth miRNA Profiling Of Germinal Center Derived B-Cell Lymphomas By Next Generation Sequencing: A Report From The German Icgc-Mmml-Seq Project', Blood 122 (21), 2500-2500.
Posted on August 16, 2013
Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SAJR, Behiati S, Biankin AV, Bignell GR, Bolli N, Borg A, Boerresen-Dale A, Boyault S, Burkhardt B, Butler AP, Caldas C, Davies HR, Desmedt C, Eils R, Eyfjord JE, Foekens JA, Greaves M, Hosoda F, Hutter B, Ilicic T, Imbeaud S, Imielinsk M, Jäger N, Jones DTS, Jones D, Knappskog S, Kool M, Lakhani SR, López-Otín C, Martin S, Munshi NC, Nakamura H, Northcott PA, Pajic M, Papaemmanuil E, Paradiso A, Pearson JV, Puente XS, Raine K, Ramakrishna M, Richardson AL, Richter J, Rosenstiel P, Schlesner M, Schumacher TN, Span PN, Teague JW, Totoki Y, Tutt ANJ, Valdés-Mas R, van Buuren MM, van 't Veer L, Vincent-Salomon A, Waddell N, Yates LR, Australian Pancreatic Cancer Gen Initiative, ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, ICGC PedBrain, Zucman-Rossi J, Futreal PA, McDermott U, Lichter P, Meyerson M, Grimmond SM, Siebert R, Campo E, Shibata T, Pfister SM, Campbell PJ, Stratton MR: 'Signatures of mutational processes in human cancer', Nature, 500(7463):415-21.


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Highland, KS Real Estate & Homes for Sale
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The national median home value is $185,800.
The average price of homes sold in Highland, KS is $82,200.
Approximately 46.09% of Highland homes are owned,
compared to 27.34% rented, while
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subset: commoncrawl


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i brought the game when it first come out (collectors edition) i had the ATV and the horse now i cant merge my account after coming back several years later i need help please
how to merge my legacy account i dont know my username or password form legacy account
Started by Grarkevon, Mar 06 2015 11:12 PM
2 replies to this topic
Posted 06 March 2015 - 11:12 PM
Posted 11 March 2015 - 01:15 AM
Go here and follow the steps: https://fe-support.g...articles/324962
Love me or hate me. I am flattered to make the minds of so many.
Posted 13 January 2016 - 01:02 PM
They don't seen to answer tickets, put in a ticket last weekend crickets so far
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Woodgrain is attending the 50th Annual Association of Millwork Distributors Convention next week. Come visit us:
Tuesday, October 21-Wednesday, October 22
Tampa Convention Center, Tampa FL
Booth 209
The Association of Millwork Distributors (AMD) has been the acknowledged leader in the millwork distribution industry for almost half a century. Through AMD, Woodgrain has the opportunity to network with other leading influencers within the industry, as well as showcase our product/service offering and continue learning about the specialized needs of our customers.
Join us next week as we unite and collaborate with the most successful millwork industry professionals!


text:
GraphicRiver 3D Galaxy S4 Case Mock-up 5092577
Photoshop \ Stock Graphic \ Product Mock-Ups \ Print \ Miscellaneous
Change \ Galaxy \ Design \ Photoshop \ Samsung \ Rotate \ Please \ Tutorial
Stock Graphic - 3D Galaxy S4 Case Mock-up 5092577 by SomethingDesign @ GraphicRiver
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Please check all my phones cases mock-ups
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Health Insurance CO-OPs Fail
October 29, 2015
Just recently four health insurance CO-OPs failed and cooperatives in Oregon, Colorado, Tennessee and Kentucky have either announced the decision decrease their operations or have been forced to stop writing policies, says senior fellow Devon Herrick of the National Center for Policy Analysis.
These cooperatives were intended to function as a so-called "public plan option" under Obamacare. But they were established to gain support from those who wanted a government health insurer to replace the private health insurance industry.
CO-OP proponents naively believed that health insurance CO-OPs would out-compete for-profit insurers because CO-OPs ostensibly do not have a profit motive.
The CO-OP program was plagued by numerous flaws from the start:
- They had no customers and no historical actuarial data to assist in setting realistic plan premiums.
- The pool of potential enrollees was sicker than average.
- CO-OPs had virtually no access to the capital markets to shore up losses.
- Moreover, the eight CO-OPs that have failed so far in 2015 owe taxpayers nearly $1 billion in loans that will never be repaid.
Some CO-OPs appear to be purposely underpricing premiums to gain market share. Thus, from the very beginning, many CO-OP executives have expected taxpayers to bail out their losses. This attempt at "gaming the system" should not be allowed, but unfortunately, the remaining CO-OPs will likely go broke owing taxpayers large sums of money.
Source: Devon Herrick, "Health Insurance CO-OPs Fail… at Gaming the System," Townhall, October 21, 2015.
Browse more articles on Health Issues


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A health catastrophe is waiting to explode in the Welbedacht area after toxic waste was illegally dumped into a resident's yard, a few days ago.
Pandemonium broke out after residents went into a panic and became ill by the fumes omitted from the waste. Authorities were called in to conduct tests and establish if the substance is hazardous and is a direct threat to human life.
Sources reveals that one person was arrested for illegal dumping of toxic waste and angered community leaders, community policing forum members and ward councillors gathered at the scene to discuss a way forward.
Environmentalists in the Chatsworth area said the problem of illegal dumping needs to be adequately addressed and perpetrators need to be given hefty fines or face jail time if they fail to adhere to the rules of the law.
Speaking to journalists, a man living in the area for 12 years and in close proximity to the dumped waste said he was shocked when he found the sludge near his home.
"We are tired of people using the area to dump and enough is enough. This is the last straw for us and we need the relevant authorities to help eradicate this problem," he said.
Meanwhile, local councillors and community policing forum members said illegal dumping is becoming a serious cause for concern and there are other related incidents which are being addressed. Montford Community Policing Forum member, Rogers Chinsamy, said a meeting will be held on Thursday to address the issue.
What are your views on this article? Have your say by posting on our facebook page or by tweeting us.
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text: In another post, the question came up about the gifts of the Holy Spirit (http://www.christianforumsite.com/t...ich-ones-do-you-have.30984/page-2#post-339800). I did a short study on the Holy Spirit not long ago and posted it on my blog (http://tropicalbound.blogspot.com/2014/05/who-is-holy-spirit.html). I'll paste it here as well: Who Is The Holy Spirit? The third person of the Holy Trinity. The man behind the scenes. Always the last in terms of billing, but most certainly not the least. The Holy Spirit is, in some sense, almost forgotten in the average Christian's life. Jesus says that you must ask God for the Holy Spirit to enter your life (Luke 11:13), but who is the Holy Spirit? The Holy Spirit is a man. Linguistically, terms used to describe God and the Holy Spirit are of a masculine nature. Throughout both the old and new testaments, references to God use masculine pronouns. Since the Holy Spirit is considered God, we can use the same masculine term of 'man' or 'him' as well. So, the Holy Spirit should be considered a person. Like a typical person, the Holy Spirit is intelligent. He knows the thoughts of man, and he knows the thoughts of God (1 Corinthians 2:11). The Holy Spirit has emotions. He loves us (Romans 15:30), and can be insulted (Hebrews 10:29). The Holy Spirit also has free will. He distributes the gifts of God as he sees fit (1 Corinthians 12:11). The Holy Spirit is able to speak. The Holy Spirit speaks to Philip (Acts 8:29), and also to those who were ministering in the church in Antioch (Acts 13:2) What can we make of the Holy Spirit's personality? What do we know about him? For one, he will be our guide, not by his own initiative, but by what he hears, and he will disclose to us what is to come (John 16:13). Like God, he is omnipresent. He will never leave our side (Psalm 139:7). The Holy Spirit is inquisitive and leaves nothing to chance. He searches all things, even the depths of God (1 Corinthians 2:10). What role or purpose does the Holy Spirit serve? God is the creator, Jesus his son is our savior, but what about the Holy Spirit? We see that the Holy Spirit is our helper (John 14:16), who will be with us forever and even dwell within us (1 Corinthians 3:16). He is the whisper you hear when you wonder if you're making the right decision, teaching us the ways of God (John 14:26). He gives us power, courage….the right words…the ability to be proper witnesses to Jesus (Acts 1:8). The Holy Spirit is the one who, through Jesus, has set us free from the law (Romans 8:1). Jesus offered himself without blemish, through the Holy Spirit, to cleanse our conscience before God (Hebrews 9:14). We have seen that the Holy Spirit is a person, who has characteristics, and serves specific purposes, but how does he accomplish his goals? What does he actually do? He speaks to us and gives us specific instruction (Acts 13:2) at just the right time (Acts 8:29). He is the one who helps us pray. When we cannot collect our thoughts before God, the Holy Spirit, who dwells in us, comes to our aid and speaks to God for us (Romans 8:26). When the Holy Spirit dwells in us, we bear fruit (Galatians 5:22). The fruit we bear includes love, joy, and peace. The Holy Spirit descended on Jesus (Matthew 3:16), to dwell in him and so to dwell in us. Anyone who does not have the Holy Spirit dwelling in them, does not belong to Christ (Romans 8:9). In your prayers, make sure you ask God to bring his Spirit into your life. Allow him to speak to God on your behalf when the words will not come. Allow him to grant you wisdom and peace. This is his purpose in your life and he will never leave your side. When you hunger and thirst for righteousness, you will be satisfied (Matthew 5:6).


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Podcast Beyond Episode 374: Too Much Telltale?
December 23, 2014 - Should The Walking Dead devs take a break or stay the course? The No. 1 PlayStation podcast discusses!
The Last Story Tops The Charts in Japan
February 2, 2011 - Final Fantasy father Hironobu Sakaguchi's long awaited Wii RPG The Last Story hit Japan last week, and managed to beat out a flood of new releases to take the top sales spot.
PlayStation Year in Review 2010
December 6, 2010 - PlayStation came in like a lion and went out like a lamb -- here's our breakdown of the what and why that was Sony's 2010 on the PS3 and PSP fronts.
Valkyria Chronicles 3 Update
December 3, 2010 - Sega Japan has sent out the latest media update for Valkyria Chronicles 3, giving us a look at one of the big changes for the sequel: character growth. We've also got screens of the main characters' powerful special skills, so take a look!
Valkyria Chronicles 3 Gets an Anime and Demo
November 9, 2010 - Valkyria Chronicles 3 is just a bit over two months away from Japanese release, and Sega has started off some major promotions for the game. Over the past week, the company has been holding demo events and press conferences to fill in all the missing pieces.
TGS: Valkyria Chronicles 3 Preview
September 17, 2010 - This isn't high school. SEGA's RPG sequel is getting serious again. Find out what to expect from the sequel to one of the best handheld games of 2010.
Valkyria Chronicles 3 Set For PSP
September 14, 2010 - The mystery platform for Valkyria Chronicles 3 has been revealed, and to the utter disappointment and utter joy of an exactly equal number of people (please be nice in the comments!), it's PlayStation Portable. Famitsu has first details today ahead of the game's playable debut later this week at the Tokyo Game Show.
Sega Accidentally Confirms Valkyria Chronicles 3
September 13, 2010 - As if that teaser site from a couple of weeks back wasn't a big enough hint, there's pretty much no mistaking it now. Valkyria Chronicles is getting a sequel, and it's going to be shown later this week.
September 1, 2010 - Valkyria Chronicles 3 was recently rumored thanks to a URL registration from Sega. Today, Sega made the rumors start up again by opening up one of those mysterious countdown sites everyone is talking about these days.


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Remembering Christ's Hospital in your Will
Legacies are vital to our ability to fund bursaries for the neediest of pupils at Christ's Hospital. We understand that decisions concerning your Will are very personal and your family will be your first priority, we hope you might consider supporting future generations of pupils by including Christ's Hospital in your Will.
Legacy bequests are free from inheritance tax and gifts of shares and property are exempt from capital gains tax. Making a Will is an important step and it is recommended that you seek independent professional legacy advice. When making a bequest in your Will, please note that the beneficiary should be the Christ's Hospital Foundation, registered charity number 306975.
1552 Society
To thank those who have let us know that they are leaving a gift to Christ's Hospital in their Will, we have created the 1552 Society. Members are invited to special school events throughout the year.
For more information, or to discuss any aspect of this further in confidence, please contact Sarah Clifton on T: 01403 247588 or E: firstname.lastname@example.com
Over £10,800 raised on #GivingTuesday – Thank you!
Christ's Hospital thanks everyone who made a gift to the Blue Fund on 29 November for #GivingTuesday. Nearly one hundred donors made a donation, raising over £10,800! This far exceeds our target of £5000 and we are enormously grateful for the generous support of parents, Old Blues, staff and other friends of Christ's Hospital who made this possible.
This was the first year the Christ's Hospital has taken part in #GivingTuesday, a worldwide initiative supported by the Charities Aid Foundation, to encourage support for UK charities. This resounding success has helped put us one step closer towards our £190,000 Blue Fund target of funding another pupil's seven year education and boarding at Christ's Hospital.
To find out more information or to make a gift to the Blue Fund, please visit the Blue Fund website at: bluefund.christs-hospital.org.uk or contact the Development Office on +44 (0)1403 247519.


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Sam Ball's Hook Island
By Doug Crowell
Recent episodes of History Channel's popular television show, Curse of Oak Island, have highlighted former island resident Samuel Ball and his various land holdings. One of these holdings has caused many people to ask, "Where is Hook Island?" You will not find it on current maps of Mahone Bay in Nova Scotia, but it is not located very far from Oak Island.
It is a small island of about 3 acres, located only a half mile off the main land of Western Shore.
Formerly owned by Daniel Vaughan (the same Vaughan family as co-Money Pit discoverer Anthony Vaughan Jr.), he sold Hook island to Samuel Ball, labourer, on March 13th 1790, as shown in the following entry in the Registry of Deeds:
As you can see in the record above, Ball paid five pounds for the island, which Daniel describes thusly, "my island situated, laying and being on the west side of Mahone Bay,in the Township of Chester described and known by the name Hook Island."
Many years later, on December 14th 1845, Samuel Ball passed away. His will left his estate to his servant Isaac Butler, and provided for the care of Sam's widow and a Mrs. Best. The story of Sam's will is very interesting and it stipulated that Isaac Butler must change his last name to Ball in order to inherit Sam's land. Whether Isaac did this or not is unclear, but he did take possession of Sam's land holdings because we pick up on the trail of Hook Island almost 40 years later when Isaac Butler (not Isaac Ball) sells Hook island to Archibald Rafuse on May 30th 1884.
In the deed transfer record, Isaac describes Hook Island as "that certain island in Chester Bay known as Hook Island situated near the Western Shore and containing three acres more or less".
Then Hook Island disappears. You can no longer find Hook Island on a map of Mahone Bay. Did it erode away over time? No. Was it renamed? Yes. What is the new name by which Hook Island is now known? You will likely shake your head and proclaim how obvious it should have been, for you can easily see the former Hook Island directly off the South Shore Cove of Oak Island. Only now it is known as Sam's Island.
So how can we be sure that this is the Hook Island Samuel Ball owned (other than it now seemingly being named after him)? The only record we can find of Archibald Rafuse selling an island is in this deed record:
As you can see from the segments of a lengthy deed record above, Archibald Rafuse sold to Anslom Rafuse "that certain island in Chester Bay in said county, known as Sam's Island and which said island lies to the east of lands of Albert Shupe and Edmond Shupe about one half mile from the mainland and containing three acres more or less."
We believe it is certain that the Sam's Island mentioned here was formerly Hook Island, and that it simply became known as Sam's Island to the locals for obvious reasons. There is no doubt that the description matches Hook Island, and the chain of custody of the land went from Sam Ball to Isaac Butler to Archibald Rafuse. Sometime during the ten years that Archibald owned Hook Island, the name was likely dropped in favour of calling it by the name of its former owner, who likely had some notoriety by that time from living on "Treasure Island".
Goodnight from The Blockhouse!
1/24/2017 02:41:38 pm
If Sam bought the island in 1790, would that be before or after his initial land purchase on oak island?
2/10/2017 08:29:03 pm
The hook island which was disappeared due to the sudden change of the climate or environment. It is not an easy task to find it again but history channel makes the episode of this island and gives us knowledge. Now the new name of this island is Sams Island. It is a good article which is informative.
Doug Crowell
1/24/2017 02:53:19 pm
After. Sam Ball bought his first lot on Oak Island in 1787.
Jackie McGowan
2/5/2017 12:53:45 pm
Did Samuel Ball ever live on Hook Island if not why do you think he wanted it and bought it. Do you think if he fount any treasure which I think he did but do you think he took it to Hook Island to rehide it?
Doug Crowell
2/8/2017 02:46:00 pm
Hi Jackie. I don't have any evidence that Sam lived there, but when Isaac Butler, Sam's servant, sold the island, it included a house, so the island was likely inhabited by someone.
Doug Crowell
1/24/2017 03:09:50 pm
Sam Ball bought Hook Island from Daniel Vaughan, whom it look like was granted the island, so Daniel was likely the first British subject to own the island. We did not bother to trace island ownership into the 1900s. Thanks for the inquiry!
1/25/2017 06:37:39 am
Given that the land is connected to Samuel Ball, do Rick & Marty feel that the connection warrants at least a preliminary look at Sam's Island to rule it out from an evidentiary stance?
1/25/2017 02:31:40 am
I've always been intrigued by this island. It's in the shape of a triangle and about the same size and angle as the swamp on oak island.
1/25/2017 04:53:55 am
Has this island ever been searched for treasures that could be linked to Oak Island?
Doug Crowell
2/8/2017 02:47:02 pm
Not that I am aware of Jason.
5/23/2017 11:58:55 pm
Would love to explore islands as well as beauty of nature.
6/1/2017 01:52:14 am
Keep sharing.
Leave a Reply.
From The Blockhouse
is published by Blockhouse Investigations and oakislandcompendium.ca
in Nova Scotia, Canada
Editors and Chief Correspondents
Kelly W. Hancock, CD
Doug Crowell
Jonathan Guy
Contributing Writers
John Wonnacott, P. Eng.
Les MacPhie,P.Eng.
Linda Rafuse
Tammy Sloan
Trevor McFetridge
Alessandra Nadudvari
Shawna Goodall
Jonathan Guy
All material and images published herein, unless otherwise credited, are copyright of Blockhouse Investigations and oakislandcompendium.ca and may be reproduced by permission only.
Views expressed in these blog posts are our own. The views of those that comment are their own.
March 2017


text:
San Jose, CA (PressExposure) May 19, 2011 -- Cloud Gaming USA has been organized on the back of some massive announcements. 2010/2011 saw companies across the globe buy into OnLive, Gaikai partnered with the likes of Intel, EA and Bigfoot. Meanwhile, the world's biggest retailer, GameStop, powered into the space with the acquisition of Spawn Labs and Impulse. In the IPTV space Playcast made huge leaps by launching commercially on 2 continents.
Although the string of game changing announcements didn't stop there. G-Cluster launched their commercial service back in September, Spoon announced their offering, and authoring monster Unity Technologies partnered with GameString.
With everyone from telcos to manufacturers investing heavily in Cloud Gaming, the sector is on the cusp of a massive explosion. However, business strategies, distribution models and advances in technology are still unclear and opinions remain divided on where the sector is headed.
On September 7-8, the Crowne Plaza, San Jose, will play host to the largest meeting of multinational companies discussing Cloud Gaming monetization, distribution and advances.
Director of Cloud Gaming USA, Alex Manessi, stated: "The response to this conference has been staggering. After confirming 9 C-level executives to speak, we knew this was going to be a huge success. However, we could never have anticipated the industry's excitement that there was suddenly a conference focused solely on the Cloud Gaming opportunity."
Companies all the way from THQ, EA and Foundation 9 right the way to Gaikai, Playcast and Cisco have sent executives to participate in Cloud Gaming USA.
Manessi continues, "This conference has a real appeal to the video-games industry as console sales drop and users migrate online. Cloud gaming platforms are being announced all over and with the rise of the connected world, core games publishers are being presented with a once in a lifetime chance to reach 12 billion connected devices. Who could ignore such a phenomenal opportunity?"
For more info visit http://www.cgconfusa.com


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Lancaster Firestone
Review for Lancaster Firestone
CHERI H. on 01/04/2015
Katrina explained everything and why. She even took me into the garage to show me the cracks in the outside of my tires because I didn't feel they needed replacing yet. They still had good tread left.
Vehicle: Volkswagen New Beetle
Service Date: 12/11/2014
Review Created: 01/04/2015 01:20 PM
Gary C. at Lancaster Firestone responded on 01/08/2015
Thank you for coming in Cheri. We appreciate your business. Have a nice weekend. See you next time.


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When I was Internet Manager for a major car dealer with a focus on marketing used vehicles, it was well known in the industry that the Nissan Sentra was more than a good deal. The Sentra compared favorably to the Honda Civic and Toyota Corolla in size, performance, gas mileage, and 5-year maintenance costs, but savvy buyers could usually save a thousand or two on the price of pre-owned models.
To this day I still recommend the pre-owned Sentra to family and friends who need good, reliable transportation, but are on a strict budget. The Sentra is great if you need a car that won't drain your bank account with excessive maintenance costs, but can save you money upfront on the purchase price.
A Modest Price Hike
My personal recommendation won't change just because Nissan announced a modest price hike on 2011 Sentra models. Nissan says they have "realigned" their option equipment for the Sentra, along with boosting the price by $100 from the 2010 models. The 2.0 Sentra sedan's Manufacturer's Suggested Retail Price (MSRP) is $16,270. This includes a $750 destination charge. The Sentra SE-R Spec V 2.5-liter with six-speed manual transmission remains unchanged at $20,830.
Want to save a ton of money before the end of the month? The 2010 Nissan Sentra has year-end incentives of zero percent financing for 60 months or up to $2,000 Retail Cash. This is a great deal on a very good car and a rare opportunity to save big bucks on a new Sentra. Remember that you can still negotiate the selling price of any 2010 model regardless of price incentives from the manufacturer. This is a way to further maximize savings.
Nissan Maxima
The 2011 Nissan Maxima has had its price boosted by $120 over the 2010 models. The 3.5 S CVT model's MSRP (including $750 destination charge) starts at $31,560. The Maxima SV CVT model starts at $34,280.
Nissan is also offering huge savings on remaining 2010 Maxima models. Get up to $2,500 in Retail Cash or zero percent financing over 60 months. These year-end incentives are available to August 31, 2010.


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Frank Fitzsimmons is backing Antrim to roar again
His side may have failed in their bid to reach Division Three of the Allianz Football League but Antrim boss Frank Fitzsimmons is certainly not prepared to allow his men to wallow in depression.
He is already cracking the whip in training for the Ulster Championship and despite having to absorb further blows in terms of losing players, he remains upbeat that his side can still prove their worth in the Ulster Championship.
Paul McCann and Marty Kane are the latest players to step aside from the panel following the abdication of Michael McCann last week.
Fitzsimmons remains, hopeful, though that former skipper Kevin O'Boyle, Mark Sweeney and Michael Armstrong will be able to link up with the squad again in preparation for the provincial showdown with Fermanagh.
O'Boyle only recently returned from honeymoon and is understood to be contemplating his future while Sweeney is currently undertaking his Actuarial examinations in Dublin.
Cargin clubman O'Boyle, a teaching colleague of Peter Canavan at Holy Trinity College, Cookstown, has given his county outstanding service, never more so than during 2009 when he helped Liam Bradley's side reach the Ulster Championship final.
They were beaten by Tyrone on that occasion before going on to lose by the narrowest of margins to Kerry in the All Ireland qualifiers.
Armstrong is recovering from injury but aims to step up his training programme next week.
With Sean McVeigh having returned from holiday and Niall McKeever slowly but surely regaining full fitness, Fitzsimmons still expects to have a respectable hand from which to deal for the joust with Peter McGrath's men.
"We had thirty players at training on Tuesday night when the boys returned after a week off and they worked hard," states Fitzsimmons.
Belfast Telegraph


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Replace the mess and hassle of a traditional mop and bucket for cleaning your floors with this SteamFast Floor Steam Mop. Using ordinary water and absorbent microfiber pads, this mop effectively and naturally cleans and sanitizes a wide variety of hard floor surfaces. It is ideal for sealed hardwood and laminated floors, as well as for concrete, linoleum, ceramic, marble, slate and other types of hard floor surfaces. The low profile makes it easy to clean under cabinets and furniture and the 19 ft. power cord gives you plenty of reach.
- Continuous steam gives you hand-free flow without triggers or manual pumping
- Cleans with ordinary tap water; no chemicals required
- Convenient foot-controlled power switch makes turning mop on and off simple and strain-free
- Weights only about 3 lb. for portability and ease of use
- 19 ft. power cord and cord wrap provides extended reach, then wraps up for neat, organized storage
- Low-profile design is engineered to easily reach underneath cabinets and furniture
- Included are 2 Easy Stick microfiber cleaning pads that are reusable and machine-washable for convenient clean-up
- ETL safety listed


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Board Director Register of Interests
There is a requirement for directors to register declarations of interests in accordance with the Companies Act 2006. The Companies Act 2006 requires directors to avoid situations in which a director "has (or can have) a direct or indirect interest that conflicts, or possibly may conflict, with the interests of the company".
The register is held by the LEP Executive and will be updated annually; as outlined in our Assurance Framework.
Register of Interest (updated 13 November 2017)


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Hi all,
I'm new to Sencha Designer and am getting my head around it, getting there.
I'm trying to dynamically set the url of the video control but it is not changing or refreshing.
When I set the url statically it works fine but if I try and set it dynamically, even though the property seem set, the video does not play.
Any hints or help greatly appreciated.
Code:video = details.child('#video'); video.url = 'images/' + record.get('id') +'.m4v';


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From Chance the Rapper, Beyonce, The Weeknd, & more.
Live performances are usually the Grammys' saving grace, and last night's ceremony was no different. The show featured 19 performances and nearly all of them delivered -- from A Tribe Called Quest, Anderson .Paak, and Busta Rhymes' call for resistance to Chance the Rapper's triumphant "How Great"/"All We Got" hallelujah to Beyonce's floral "Love Drought"/"Sandcastles" medley and beyond.
See the full list of 2017 Grammy winners here. Watch the best performances from the 59th Grammys below.
A Tribe Called Quest, Anderson .Paak, & Busta Rhymes
A Tribe Called Quest perform with Anderson .Paak, Busta Rhymes and Consequence at the #GRAMMYspic.twitter.com/Kz35sUTEs7— Wolé II (@Kingwole) February 13, 2017
Chance the Rapper
Chance The Rapper, Kirk Franklin and Tamela Mann brought the church to the #GRAMMYs 2017 pic.twitter.com/bB51vkTasu— What's Trending Sa (@whatstrendingSa) February 13, 2017
John Legend & Cynthia Ervio
The Weeknd & Daft Punk
RT— Fest Jumpers (@FestJumpers) February 13, 2017
Aquí la presentación completa de The Weeknd y Daft Punk en los #GRAMMYspic.twitter.com/l9oV6mWnMo
Alicia Keys & Maren Morris
Can I get a Hallelujah! @MarenMorris & @aliciakeys ! #email@example.com/euCLJMHfr6— Rick Daniels (@OnAirWithRick) February 13, 2017
Prince tribute (Bruno Mars & The Time)
#TheTime opens up for the @prince#Grammys Tribute! pic.twitter.com/KLL9sZTdh6— Rick Daniels (@OnAirWithRick) February 13, 2017
FULL "Bruno Mars" Tribute to #PRINCE at the #GrammyAwards#Grammys— McCracken Software (@lotterypicker) February 13, 2017
#brunomars#MAGA "BEE GEES" #GrammyAwards "Bruno Mars" #PRINCE#Trumppic.twitter.com/iXUgvjGu19


text: In-Game Examine Window Ring of Walled Flesh other resources EQ2U · LootDB · EQ2LL · ZAM · Census xml Ring of Walled Flesh FABLED ATTUNEABLE LORE-EQUIP HEIRLOOM +40 agi +40 wis +48 sta +235 health +100 power +588 vs noxious +378 vs arcane +5 Defense +5 Parry 5% Crit Chance Slot Finger Level 80 (Tier 9) Obtain: From the Exquisite Chest of Senior Loyalist Tilas in Tomb of the Mad Crusader. What does this information mean? NotesEdit Retrieved from "http://eq2.wikia.com/wiki/Ring_of_Walled_Flesh?oldid=459446" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Equipment Finger (Inventory Slot) Fabled Equipment Noxious Resistance (Equipment) Arcane Resistance (Equipment) Defense (Equipment) Parry (Equipment) Crit Chance (Equipment) Tier 9 Equipment Fighter Equipment Warrior Equipment Berserker Equipment Guardian Equipment Brawler Equipment Bruiser Equipment Monk Equipment Crusader Equipment Paladin Equipment Shadowknight Equipment Mage Equipment Sorcerer Equipment Warlock Equipment Wizard Equipment Enchanter Equipment Coercer Equipment Illusionist Equipment Summoner Equipment Conjuror Equipment Necromancer Equipment Channeler Equipment Cleric Equipment Inquisitor Equipment Templar Equipment Druid Equipment Fury Equipment Warden Equipment Shaman Equipment Defiler Equipment Mystic Equipment Beastlord Equipment Predator Equipment Assassin Equipment Ranger Equipment Bard Equipment Dirge Equipment Troubador Equipment Rogue Equipment Brigand Equipment Swashbuckler Equipment Tomb of the Mad Crusader Dropped Items Articles missing itemlink Add category Cancel Save


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I've heard that you're not supposed to put LEDs in closed fixtures such as domes because they require airflow to cool them. Is this true? What about a dome that covers the bulb but is open on top, like a pendant? I've not seen such a warning on the manufacturers' packaging.—Joe Cesa Cumming, GA
It's generally true that LEDs last longer if they are kept relatively cool, and almost all LED bulbs have warnings on the bulb and packaging that indicate where the bulb can and can't be used. If there isn't a specific warning against using the bulb in certain conditions or fixtures, then it should be OK. But keep the packaging and receipt should the bulb burn out prematurely and you need to use the warranty.
—Consumer Reports
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HK2 Hentai Kamen The Abnormal Crisis 2016 1080p BluRay x264-ROVERSNov 10
Plot: News about the disappearance of panties is covered every day." Kyosuke (Ryohei Suzuki) still wears Aiko Completo (Fumika Shimizu) panties to battle evil. Meanwhile, Aiko has mixed emotions and decide to get her panties back from Kyosuke. Kyosuke suffers from the loss of Aiko completo panties and disappears. The biggest enemy yet appears in front of Kyosuke
Genre: Comedy
IMDB Rating: 6.1/10 from 76 users
Directed by: Yûichi Fukuda
Starring: Osamu Adachi, Hirofumi Arai, Narushi Ikeda
Release Name: HK2.Hentai.Kamen.The.Abnormal.Crisis.2016.1080p.BluRay.x264-ROVERS
Size: 7.64 GB
Video: MKV | 1920×808 | 8652 kbps
Audio: Japanese | AC3 | 640 kbps
Runtime: 1h 57mn
Subtitles: English forced
Samples: Video @ #1 – #2 – #3
Links: iMDB |
Trailer | NFO | Torrent Search
Download: NiTROFLARE – UPLOADED – RAPiDGATOR – UploadRocket
Next Post :Junior Bake Off UK S04E04 Heat 4 HDTV x264-JIVE


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Minster FM News
Three Women Released Without Charge After Selby Market Place Fight
12:11pm 17th June 2013
Three women arrested after a fight which took place in Selby market place, at 3.30am on Friday 14 June have been released without charge.
After the fight, three women from Humberside and three men from West Yorkshire were arrested on suspicion of affray.
The three women were released without charge, on Friday 14 June 2013.
The men aged 21, 22 and 28, all from Knottingley, West Yorkshire, have been released on bail to allow for further police enquiries.
Anyone who can help with this enquiry is asked to contact Selby CID on 101, select option 2 and ask for Ash Khan. Alternatively information can be emailed to firstname.lastname@example.com.
Or call Crimestoppers anonymously on 0800 555 111 quoting reference number 12130096486.


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It had been a few months since Alex brought Mike to our bed and I was longing for another threeway. My surprise was the black boy who accompanied Alex, wow he was drop dead gorgeous and when I saw what he was packing I nearly had an instant orgasm. Arif's cock was like a stallions and the boys seemed to ignore me for ages whilst they sucked each other then it was my turn for a jaw aching before telling Arif to fuck me which he did expertly, it was worth the pain. Want more of him now
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If you like the taste of cum, you are not only bi curious but really bisexual like me
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made me drul & got me hot & hard.
Very sexy wish i could join them.
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wow would of love to been with them
I had been begging Alex to arrange another threesome with Arif and eventually he did. Oh wow his big black cock looked even bigger as the boys began to suck one another in between pleasuring my pussy. This time I was determined to suck Arif off first and when he spunked it overflowed my mouth and Alex joined in sharing my reward. I love having two guy's at the same time especially when they are bisexual.
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i would suck cock at a chance to give her a creampie
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Mens NFL Jersey Atlanta Falcons Matt Ryan Sz L/XL (52)
Sold for:
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Brand NewMatt Ryan Atlanta Falcons Football Jersey!! Sizes: Mens L/XL (52) This is a brand new, Matt Ryan, NFL authentic jersey by Reebok. Numbers and name are stitched on, this is not a screen printed jersey. This jersey retails for over $75. Great quality, top of the line! Will ship within one day of receiving your payment! Please view our feedback to hear from our customers who have also purchased jerseys.


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Helpfull traveller that will help you to get some stuff you need such as branded cosmetics, souvenirs, starbucks items, food, snacks, medicine, soap, shampoo, designer bags, electronics and many others within legal and my luggage capacity :D
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Singapore - Jakarta
Singapore - Jakarta
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I meant to post the two final trip entries many days ago, but this week really got away from me. And I'm leaving on Wednesday for another 2-1/2 week trip, so I definitely need to finish this up!
Some general notes on Vienna: gorgeous, very walkable, lots to do, museums are more expensive than Paris, restaurants are as expensive as Paris but the service is atrocious.
After a very uncomfortable night on the train to Vienna, we arrived at the station and began walking to our hotel. (One of the advantages of traveling light with medium-sized packs was that we could walk everywhere and see a lot.) We stopped at the first coffee house we saw. It was also an underwear store.
Once we dropped off our packs, we headed out to walk around town. I trust you are seeing the theme here with Ed and statue-posing. Be thankful I left out the one of (a fully clothed) Ed with a naked Greek in the Louvre. Here he is with Goethe.
We went past the opera house and then to Hotel Sacher, which was highly recommended by our Rick Steves guide (Best of Europe 2009). We greatly enjoyed the famous Sachertorte.
We are here at Hotel Sacher, where we've secretly replaced the fine coffee they usually serve with Folgers Crystals. Let's see if anyone can tell the difference.
We rushed off to St. Stephen's Cathedral so we could look around before the daily Mass started. Here's the incredible pulpit.
The roof was also amazing.
After St. Stephen's, we picked up some famous chocolate at Demel before touring the Hofburg Palace.
Next we toured the Vienna Opera.
These are the seats at the Vienna Opera. By waiting until 45 minutes after the opera started that night (a tip from Rick Steves), we were able to score some free (used) standing room tickets at the very top for the sold-out performance of Lucia di Lammermoor.
We spent the evening relaxing at our hotel, which was far, far nicer than we expected (Hotel Pension Corvinus). We had a huge jacuzzi tub, separate shower, and a kitchenette. There was a grocery store nearby, so we were able to eat a few meals very cheaply.
The next morning, we ride the tram around the Ring road. Unfortunately there was an error in our guidebook that had us on a tram that took us about an hour out of our way. We ended up at Friedrich EngelsPlatz, which, if you know me, is pretty much the last place I ever want to be. But we managed to get back on track. Here is Athena in front of the Parliament building.
Here I am outside the national library (Österreichische Nationalbibliothek), just before our visit to the excellent Kunsthistorisches Musem.
We ended our visit with coffee and a snack at Cafe Schwarzenberg. The food was great, but our waiter was awful (as usual for Vienna). At the end, he made a point of telling us that "service is not included" in the bill. After we left, I said to Ed, "I'll say service is not included!!"
Then we made our way to a different train station for the journey east to Prague.
Sunday, May 3, 2009
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text: Glass floors are gaining popularity day by day. The reasons are many. Properties of a glass floor The reflective properties of glass make it an excellent choice for floors. Glass floors make the most out of natural sunlight, making the room look brighter and bigger. Many a time, it is not possible to break down … Read More


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Nonstop Sound talks to The Shortsleeves about the chip music movement, where artists compose using old-school video game systems like Nintendo and Atari. The movement is worldwide, but New York is the center of it, they say.
Published at 9:00 AM EST on Apr 5, 2011 | Updated at 11:24 AM EST on Apr 6, 2011


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Filter by content types:News stories Blog posts Feature articles Polls Image galleries
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Roccat celebrates 10 years with the Kone Aimo mouse
Which companies come to mind when you're thinking about gaming input devices, gerbils? Is Roccat on that list? If not, it probably should be....
Type: News story Tags: Input devices
Razer Blackwidow Ultimate gets a spill-proof step-up
One of the bad things about paying three figures for a keyboard is that you feel that much worse when you break it. Back when...
Type: News story Tags: Input devices
Nvidia upgrades its DGX SaturnV cluster with Tesla V100 chips
Nvidia has a lot to talk about at the 2017 Supercomputing Conference, thanks to the presence of its GPUs inside 34 recently-introduced members of...
Type: News story Tags: Servers
Tuesday deals: a primo Gigabyte B350 Ryzen board for $70 and more
Sneeze, sniff, rinse, repeat. That's been my day so far, folks. The temperatures around here had a sudden whiplash from "almost summer" about three weeks...
Type: News story Tags: Motherboards Power Displays
Early benches of recent ARM server CPUs show serious promise
There's been a lot of talk in recent months about ARM-based server CPUs in one form or another. While it's been a reasonable...
Type: News story Tags: CPUs Servers
Intel quietly kills off next-gen Knights Hill Xeon Phi chips
The SC '17 conference is taking place this week, and while many companies are taking the opportunity to launch new products and services at the...
Type: News story Tags: CPUs Servers
Intel pumps the Optane SSD DC P4800X to 750 GB
Optane SSDs have left a good impression here at TR. Some folks sneer at the performance claims Intel makes for them, and it's true...
Type: News story Tags: Storage Servers Workstations
Thursday deals: sales on monitors, SSDs, Logitech gear, and more
Hello, gerbils! It's a difficult morning here at TR HQ. Yesterday's industry announcements were a perfect one-two punch combo to our collective jaws,...
Type: News story Tags: CPUs Storage Displays Input devices Mobile computing
Qualcomm begins shipping Centriq 2400 family of ARM server SoCs
Qualcomm announced that it's begun commercial shipments of its Centriq 2400 family of server CPUs today. Fabricated on Samsung's 10-nm FinFET process, the Centriq...
Type: News story Tags: CPUs Servers
Tuesday deals: A Threadripper 1950X and mobo for $1000 and more
Season's greetings, gerbils and gerbilettes. As you may have noticed, it's now dark by 5:30 PM and sleep schedules everywhere are taking a beating. The...
Type: News story Tags: CPUs Multimedia Power Storage Displays
Razer Naga Trinity mouse and Tartarus V2 keypad are ready for action
I have a sickness, and the only cure is more mouse buttons. My current mouse is a SteelSeries Rival 500, and before that I...
Type: News story Tags: Input devices Gaming
BitFenix Formula Gold power supplies keep it simple and quiet
Did you know BitFenix sells power supplies, gerbils? The company already has a lineup of fancy modular units with 80+ Gold certification, but not...
Type: News story Tags: Power
Cooler Master bedazzles the RGB Hard Gaming mouse pad
Now that pretty much every part of a gaming PC can be optioned with factory-fitted RGB LED illumination, manufacturers have...
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BenQ Zowie EC1-B and EC2-B are spartan pointers for serious gamers
BenQ's Zowie gaming division just released the EC1-B and EC2-B gaming mice. Like their predecessors, the two rodents are as...
Type: News story Tags: Input devices
SteelSeries chops keys off the Apex M750 TKL keyboard
The number of choices available for the most particular typists and gamers has expanded again with SteelSeries' Apex M750 TKL. The new offering is...
Type: News story Tags: Input devices Gaming
Friday deals: a Samsung 850 EVO 500GB for $0.28/GB and more
Geez, guys. We're still dizzy and reeling from the lightning-quick pace of releases over the last few days. We have Ryzen mobile APUs to...
Type: News story Tags: Cases Power Storage Memory
Razer sets the mood with the Cynosa Chroma keyboards
Razer names its mechanical keyboards after spiders. The Cynosa genus has just two species listed in taxonomic records, so it's rather fitting that Razer has two...
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AMD stayed 100% in the black in Q3 2017
AMD has posted its third-quarter financials, and the company ended up in the black across the board. The company took in revenue of $1.64 billion,...
Type: News story Tags: CPUs Graphics Servers
|G.Skill's DDR4-4400 kit seizes the four-module memory speed crown
|Rumor: December Radeon drivers will bring a performance OSD
|Intel spins up new assembly-and-test site for Coffee Lake CPUs
|Deal of the day: A laptop with an i5-8250U and Pascal graphics for $680
|EVGA DG-7 cases cover every base
|Radeon 17.11.2 drivers take the fight to the Galactic Empire
|Intel readies a family of 5G modems and talks up a storm on 28 GHz
|National Fast Food Day Shortbread
|OnePlus 5T stretches its screen without straining wallets
|The amount of flak EA are catching for the microtransaction BS is just glorious. I doubt it'll amount to anything but EA are being investigated by the...


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Islamabad, Aug 6: A senior Baloch leader on Wednesday, Aug 5 asked the Pakistani government to prove its allegations of Indian interference in Balochistan and said it is just an excuse for its military operations in its province.
Speaking at a seminar, Shahzain Bugti, president of the Jamhoori Watan Party said, "The federal government should prove its allegations about Indian interference in Balochistan."
He also said, "We are accused of being pro-India. We would have voted for inclusion of Balochistan in India in 1947, if we had been in favour of India."
The issued of alleged Indian inference in Balochistan came into limelight after Pakistan alleged that a dossier was handed over by Pakistan's Yousuf Raza Gilani to his Indian counterpart Manmonhan Singh during their meet on NAM sidelines at Sharm el-Sheikh in Egypt.
OneIndia News


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aka Alex Sander, wannabe DJ/Musician from Berlin
You can book me for your club/lounge/bar!
Visit my facebook page to get more details!
Listen to all music and sounds of Musikalische Selbstbestimmung and follow this user by signing in for free.
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Minotor - Join Together
Kastis Torrau - Cold Water
Rockaforte - Bad Time Are Gone
Arnas D & Donatello - Strangers
Sino Sun - Give Me What U Got (Benn Finn Remix)
Stephan Bodzin - IX (Victor Ruiz Remix)
Rodriguez Jr. - Esperanza
Matthias Meyer - Reichenbach
Marc Romboy - Hypernova (Stephan Bodzin Remix)
Fabs# - Harm
David Eye - The Shining
Victor Ruiz & D-Nox - Arise
WhoMadeWho - Hi & Low (Emanuel Satie Remix)
Sascha Braemer - People


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Northern Lights Trailer (2009)
21 March 2009 Drama, Mystery, Romance 120 mins
Hoping to leave behind troubled days in the Baltimore city police department, Nate Burns (Eddie Cibrian) journeys to Alaska, where he takes up a quiet life as a small-town sheriff and begins a romance with spirited bush pilot Meg Galligan (LeAnn Rimes). But when Meg's father turns up dead, Burns finds himself thrust into the limelight of a dangerous murder investigation. Rosanna Arquette co-stars in this drama based on the novel by Nora Roberts.
Watch the official Northern Lights 2009 trailer in HD below or find more Northern Lights videos on Vidimovie.