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Thanks, Gunter...I will try what you suggest...We'll get this squared away...;) I'll be back...
Okay, I renamed the file and put a .GIF and got this page...Also, should the little circle have a dot in it where it says Personal Signature?
Description: An unhandled exception occurred during the execution of the current web request. Please review the stack trace for more information about the error and where it originated in the code.
Exception Details: System.NullReferenceException: Object reference not set to an instance of an object.
Source Error:
An unhandled exception was generated during the execution of the current web request. Information regarding the origin and location of the exception can be identified using the exception stack trace below.
Stack Trace:
Version Information: Microsoft .NET Framework Version:2.0.50727.5485; ASP.NET Version:2.0.50727.5491
Sandy hang tight for a bit and let me sort through your messages here and at The Garden - I think I have an idea what is happening and a way to lessen the steps for you when creating your Personal Signature.
catandbroomH17.gif is a corrupted file now. Too strange, I can't tell what happened.
waiting to see if the Kid comes up with something ...
From what I can see your signature block is completely empty so lets try a new signature using the editor's tools and see if you get the same problem.
Step 1:
If the image you wish to use is in your Files on Delphi, go ahead and click on the name so you can see the image. Look in the address bar for the image's address and copy that instead of the image itself. Just highlight the entire thing and copy as you normally would.
Step 2:
Open your Personal Signature Editor from the Preferences page and click in the Insert Image or Photo button and then choose From the Web
Step 3:
A new box will pop up and you can paste in that web address you copied earlier.
Click OK and then Save
If the image is on your computer you'd just choose From My Computer back in Step 2 and follow the prompts to upload it that way.
Thank you...
I have even tried the gif files and they do the same thing...Waiting and hoping...Just remember I do appreciate all the time...Thanks.
It worked!!! Thank you...Do I do these steps each time I need to change my siggy? I honestly can't thank you enough...
You can skip uploading it to your Files if you are just going to use it in your Personal Signature. When you use that editor to create your sig and upload a picture From your Computer it actually stores it in your Files anyway. In a folder there called Signature files.
Wait a few days and see if you can use your old method again. It is a bit shorter, Julea mentioned using Controls V to paste, if you are using a keyboard just click where you want the image to appear but paste it in by pressing Control (Ctrl on many keyboards) and V at the same time. That might work better than use the Paste under Edit has been the last few days.
Thank you...I do appreciate your help and Gunter...I wish I had those smarts when it comes to computers...;)


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Fibromyalgia is something I never believed in its existence until I was diagnosed of the chronic disorder. I am a businesswoman married with kids. At the onset of my life, I don't enjoy sedentary life. I always go from a friend to another. I used to attend any social function invited.
Everything happened in about five years ago. One day, I woke up and I felt something was not actually right. I was feeling general body weakness, headache and pain in some regions of my body which I was later told that those are tender point of fibromyalgia. I should have gone to my personal physician to complain but I thought it was an ordinary emotional stress which will disappear before the day would run out. But I was wrong, completely wrong in my precision. This was because the symptoms persist.
When I realized that the symptoms were rapidly improving daily, I began to feel worried. What sort of sickness was this? Then I saw good reason why I have to tell my doctor what was wrong with me. After her test she diagnosed fibromyalgia. I was very scared and impatient when she said this. I quickly rushed home, grabbed my phone and searched the meaning of fibromyalgia and everything I needed to know about the disorder. The information I obtained from the internet increased my fear. I was very scared when I heard there is no known cause and cure and it is predominantly in women.
My doctor started giving me some analgesics but I didn't see any response. So, she decided to prescribe FDA-approved drugs for fibromyalgia treatment. At first, it was reasonably better but later it didn't respond to the pain. I was so perplexed because I was gradually losing my sound health and fitness. I stopped using all the drugs because of no observable changes and I continued my search for my relief.
A friend of mine invited me to yoga classes which she said if properly done, I will be relieved from fibromyalgia. That time I was ready to do anything so as to be cured from this chronic musculoskeletal pain. I got myself enrolled into the yoga and underwent a variety of rigorous training sessions. Unfortunately, this didn't work for me too.
After a number of queries from my workplace majorly for incessant absence from work, I was relieved of my duty even when I was not yet relieved of fibromyalgia. This added to my problem emotionally you know. I was having problem of relating friendly with people even my kids at home because I felt severe pain at the tender points. I couldn't carry them playfully. Spending weekends with them by playing all along became a serious challenge. This fibromyalgia pain was obviously affecting my family.
I was already having the impression that I can't be relieved from this strange pain. I was gradually losing hope of regaining my normal state of health. I was very sad seeing the painful state as the normal state. Then, I was invited to a physical therapy where I was told the pain would become a past tense then. The physical therapist also included cognitive behavioral therapy because of my depression. The pain was first aggravated that the tender points were even more painful than before. After some sessions, I was gradually relieved but the period of pain was greatly prolonged.
I stopped the training. I was still nursing this pain and the fatigue didn't allow moving here and there anymore. I just sat at home all day. I was waiting for unexpected miracle to come and remove the pain from me totally. I started praying over it.
Then one day my husband who had been very supportive since I have been battling with fibromyalgia came shouting 'Eureka!' I was beginning to ask what did he lost and found and he said that he was surfing through the internet and saw this product named 'Fibromyalgia Pain Patch', Stress and Anxiety Patch and Bio Energy Patch. He was telling me the description of these patches and how they were to be used for effective result but I didn't show any interest in what he was saying. I have totally lost hope. I didn't want to waste my time and little energy trying this again. After too much persuasion from my darling I decided to also give it a try knowing that it won't yield any favorable result but you know what? I was shocked and surprised.
Within a week or two that I started using the patches I noticed dramatic improvement of my overall health. It was like magic. After some months like three to be precise, I have regain seventy-five percent of my health. I started working again and the family was becoming a happy one it was known to be. Consistency use of these patches remedied fibromyalgia. Yes, it worked for me. It can work for you too.
- http://nationalremedies.com/relax-bio-energy-patch/
- http://nationalremedies.com/fibromyalgia-pain-patch
- http://nationalremedies.com/stress-and-anxiety-patch/

subset: commoncrawl


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Oops, sorry but it looks like we have sold the last one! See others just like this >>
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Product details
 Lace Insert Aztec Playsuit For £5!
- 35% Cotton, 65% Polyester
- L: 34" (Shoulder To Hem)
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|17 Apr 2011
Win7 Enterprise, Win7 x86 (Ult 7600), Win7 x64 Ult 7600, TechNet RTM on AMD x64 (2.8Ghz)
Did you ever get your slave drive hooked up & running ?
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Original Retail Price: $23.00
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|Super immunity?
One of the researchers, Christopher Lynn, PhD, an associate professor of anthropology, had noticed that when he got a tattoo, he ended up exhausted--he says, from the stress (of a needle jabbing thousands of times into his flesh).
As with exercise, repetition of the stress can reset the stress point of the body higher, he thinks.
He teamed up with two other researchers and enlisted some volunteers at tattoo parlors in the area.
The colunteers completed a questionnaire about their tattoo experience. Their saliva samples were then analyzed before and after, measuring the levels of immunoglobulin A, an antibody in the gastro and respiratory system, and of cortisol, a stree hormone that suppresses immunity.
The IA dropped in those receiving their initial tattoos--from the stress. But it dropped less significantly with subsequent tattoos.
Lynn says he is interested in "catchy" subjects--subjects that catch students' interest in anthro and blow their minds a bit.
Would I call this scientific? Probably not... And, anecdotally, I did not get sick or "exhausted" after either of my tattoos...what does that indicate?


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DynaVox- Xpress. Sigrid Rosa. Who makes it and what is it? . The device is made by the Dynavox Mayer Johnson Company. The Xpress is a handheld augmentative communication device for individuals with speech and learning challenges. This device is portable, discreet and easy to use.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Sigrid Rosa
The Xpress is a good choice for those with:
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DynaVox Mayer-Johnson2100 Wharton StreetSuite 400Pittsburgh, PA 15203
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08-18-10, 08:33 #1Registered User
- Join Date
- Apr 2010
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Unanswered: Optim Database Administrator - Help?
I just installed "IBM Optim Database Administrator 2.2.2 Demo" on WindowsXP.
Every time I try to use the Change Management the programm crashes -.-
There's no error message.
In Windows Task Manager I can see that the task is not responding.
Any ideas?
Thanks in advance!


text:
La violencia en Latinoamérica y sus efectos sobre la inversión y la educación/Violence in Latin America and its Effects in Investment an Education
La región de América Latina se caracteriza por tener las tasas más elevadas de violencia criminal. La elevada violencia, además de traducirse en graves consecuencias sociales, conlleva efectos económicos trascendentales. El presente trabajo trata de profundizar en estos efectos. El mismo ofrece un estudio de la literatura sobre los principales efectos económicos de la violencia. El estudio se acompaña de un análisis de datos de panel para los países de la región, durante el periodo 1995 – 2002, que investiga en la relación entre violencia e inversión en capital físico y humano. Del análisis se desprende que la violencia afecta negativamente a la inversión en capital físico y, a partir de un determinado umbral, a la conclusión de los niveles educativos primarios. The region of Latin America is characterized by having the highest rates of criminal violence. This violence has burning social end economics effects. This paper tries to go into these effects in depth. We make a review of the literature about main economic consequences of violence. In addition, we present a panel data for Latin American countries during the period 1995 to 2002, which analyses the relationship between violence and investment in physical and human capital. This analysis confirms that violence affects negatively to investment in physical capital, and, from a certain threshold, to the primary completion rate.
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Volume (Year): 27 (2009)
Issue (Month): (Diciembre)
Pages: 781(22á)-781(22á)
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References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Gary S. Becker, 1974.
"Crime and Punishment: An Economic Approach,"
NBER Chapters,in: Essays in the Economics of Crime and Punishment, pages 1-54
National Bureau of Economic Research, Inc.
- Gary S. Becker, 1968. "Crime and Punishment: An Economic Approach," Journal of Political Economy, University of Chicago Press, vol. 76, pages 169-169.
- Fajnzylber, Pablo & Lederman, Daniel & Loayza, Norman, 2002. "What causes violent crime?," European Economic Review, Elsevier, vol. 46(7), pages 1323-1357, July.
- Heather Berkman, 2007. "Social Exclusion and Violence in Latin America and the Caribbean," IDB Publications (Working Papers) 1962, Inter-American Development Bank.
- Heather Berkman, 2007. "Social Exclusion and Violence in Latin America and the Caribbean," Research Department Publications 4534, Inter-American Development Bank, Research Department.
- Cao, Liqun & Solomon Zhao, Jihong, 2005. "Confidence in the police in Latin America," Journal of Criminal Justice, Elsevier, vol. 33(5), pages 403-412.
- Jérôme Vandenbussche & Philippe Aghion & Costas Meghir, 2006. "Growth, distance to frontier and composition of human capital," Journal of Economic Growth, Springer, vol. 11(2), pages 97-127, June.
- Miron, Jeffrey A, 2001. "Violence, Guns, and Drugs: A Cross-Country Analysis," Journal of Law and Economics, University of Chicago Press, vol. 44(2), pages 615-633, October.
- repec:col:000090:006707 is not listed on IDEAS
- Kristin J. Forbes, 2000. "A Reassessment of the Relationship between Inequality and Growth," American Economic Review, American Economic Association, vol. 90(4), pages 869-887, September. Full references (including those not matched with items on IDEAS)
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Curriculum Connections: Science, Technology, Engineering, Art, and Mathematics
Explore the wonders of the galaxy by traveling at the "speed of thought" in this interactive performance that takes students on a virtual tour across the universe through the scientific process. Schools will be invited to participate in an online experience with Janet and an astronaut prior to this performance.» More Info


text:
I'm sure some of you have already read this article from Wait but Why about Generation Y, but if not I strongly suggest you take a gander. In a nutshell the article dissects why millennials not only have inflated opinions about themselves and their worth, but why most of them are also incredibly unhappy.
When I grew up I was taught to believe that I could be whatever I wanted if I worked hard enough, and I was special. I believed this with my whole heart, which is the main reason I strived to be a filmmaker for so long. The thing that I didn't realize was that all of my peers were taught the exact same thing.
So here I am in a generation where everyone thinks they are special and believe they will go on to become CEOs or Oscar winners, but in reality most of us will be lucky to afford retirement. This may sound pessimistic, but that could just be the Generation Y disappointment coming out in me.
As silly as the stick-figure cartoons might be, after reading this article it was as if a lightbulb switched on in my head. Since the beginning of 2013 I've been hopping from one incredible experience (Thailand) to another (getting hitched), and I thought that moving to Toronto would be the next amazing lily pad for me to jump onto.
So far, it hasn't been. Truthfully, it's been full of disappointment and frustration. I know I haven't been here long, but let's just say my expectations for coming here were incredibly inflated and I'm now having to come to terms with my reality.
What did I expect to happen when I got here? In all honesty, I hoped to get a mid-level position at a big arts organization or entertainment/media company in my first or second month of being here. There are a ton of jobs in Toronto, and being the ambitious and hard-working person that I am, I didn't think that I would have too much trouble finding employment.
The reality is that I'm entering my third month here and although I have gotten about 6 interviews since I started my job hunt, I've applied to over 80 job postings. I was expecting to be on my flowery patch of grass with my unicorn by now, but instead I'm standing on a pile of dirt asking myself "WTF?"
If this wasn't bad enough, just like the article mentions, every day when I log onto Facebook, Twitter, LinkedIn, or Instagram I'm bombarded with information telling me how everyone I know is having a way better time than I am. I know everyone just uses social media to tell the world how awesome they are, I do it too, but that doesn't mean it doesn't suck.
I know I would be way happier in my situation if I wasn't constantly made aware that so-and-so was going to Jamaica for some fun in the sun or what's-his-face just bought an $800,000 house. But alas, that's the world I live in, and the world my kids will live in, so I guess I better just get used to it.
So what does all this mean? It means that I, and most millennials for that matter, need a big ol' reality check. I don't necessarily want to lower my expectations or settle, but I do think it's important for me to take a moment and question what I really want in life, why I want it, and then be more realistic about how and when I can achieve it.
Just like the article suggested, I'm going to stay wildly ambitious, but I'm also going to try and ignore everyone else's flowery green grass, I'm going to stop thinking I'm a special and unique snowflake until I have something to show for it, and I'm going to enjoy the journey goddamnit! To hell with the destination; I'm throwing the map out of the car window!


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Register for Refuge here
Refuge is a fun and exciting weekend for those age 18 and up, to get away from the world for a little while. (Hence, the name Refuge!) Refuge focuses on young adults. Of course, that's more a state of mind than an actual age, but this event is for those out of high school that would like a retreat setting to connect with others. If you like hanging out with young adults for a weekend of teaching, music, Bible study and fun, then you are young enough to attend. Don't let your age stop you from attending. The retreat is located on beautiful Lake Waubee at Camp Mack in Milford, IN.
Registration begins on Friday, Feb 26 at 7pm and concludes on Sunday, February 28 at 11am. This year's theme is "At the Movies" led by Pastor Dan Cain. Cost is $100 per person IF enrollment AND online payment is received by February 5, 2015. After December 31, the cost will be $125. If two or more from the same household enroll and pay by Feb 5, they may each pay just $75. After February 5th, ALL enrollees will be $125 each.


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When gaygamer.net took a look at that wretched "acts of lust with booth babes" contest Paul posted about, the site came up with a pretty great idea: enter the contest! Only, their photo submission was a pose with a booth bear from last year's PAX.
And whaddya know, the photo got picked as a runner-up winner, which was all the ammo gaygamer.net needed to rebuff the prize:
I think the contest was somewhat sexist, misogynist, and exploitive [sic], especially since you were sending fans upon ANY booth babe at SDCC; however, as a gay man, I also saw this PR stunt as missed opportunity that resulted in what appears to be a narrow minded view as to what your game's audience can truly be. While I'm not sure if it was intentional or not, this stunt projected a view of your target demographic as lustful heterosexual males, when in reality a larger and larger portion of the gaming population are women and LGBT people.
I sent in my photo of me with a burly man that I took at PAX last year as a humorous portrayal of how your contest is not only misogynistic and demeaning to the women that attended the conventions, but also to anyone that doesn't follow the hetero-normative ideal.
In declining the prize, the author suggested a few uses for the $240 EA gift certificate he would've received, including: "the next time you go to Hooters (for the wings, of course), leave a $240 tip for your waitress in a karmic way of balancing out what has been done."
Worth noting, this contest arose barely one week after EA hosted a GLAAD panel in San Francisco on homophobia and intolerance in online gaming and social networking. Today, GLAAD posted the complete two-hour video feed of the panel, which includes local Microsoftian Stephen Toulouse, game makers, and reps from gaygamer.net and the ESA games ratings board.
The panel's separate snippets are full of engaged conversation, but it's frontloaded with pontification on the issue of hyperized trash talk, not hard ideas on what, if anything's, to be done. Toulouse's hands appeared tied with his numerous "we are working on better tools" responses about Xbox Live, as he didn't back up most of those with timetables or specific ideas for changes. To be fair, his ownership of Xbox Live's faults is encouraging:
It's been our ability to sit and say we don't know the right thing to do and the right way to do it sometimes. What expertise can you help us with that will allow us to enable self-expression, safer communities? We want to know these things. It's my team's job to make it a safer experience on Xbox LIVE and I'm going to talk to anybody who has the expertise to do that.
Yet little in the panel hinted to true strides toward promoting tolerance or encouraging gamers to stand up against hateful members of their online community. Because, really, clicking the "report" button in an online game is a silent aggregator, not a step toward the confrontation and conversation that is a necessary tool against intolerance. And some people on the panel didn't even seem ready to accept that notion: at one point in the snippet above, a game maker states, "Some gamers are truly offended by homosexuality. Whose offense is more valid?" That weak-willed statement takes fifteen steps beyond moral relativism and gives gamers' hate speech a free fucking pass. Looks like we've got a ways to go.


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Isabella Stalker/John Cram - 1818,Scotland
I am looking for any information on Isabella Stalker. She married John Cram March 21, 1818 in Milton of Aberlednoch, Perth, Scotland. Not sure when they came to Canada. They had two daughter,s Jessie, and Margaret, I believe that there are more children. My e-mail is email@example.com


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Results 1 to 1 of 1
Thread: Help with Text Block formatting
11-13-02, 16:43 #1Registered User
- Join Date
- May 2002
- Location
- Springfield IL
- Posts
- 2
Unanswered: Help with Text Block formatting
I have been trying to format a letter as an access report and the main body of the leter is a block of text with some variables from a database. I need to be able to change the text formatting within the block of text without losing the flow of the letter (no new lines or spacing). For example:
textBody = "Dear " & strPerson & "! You dues should be in between " & strDueDateRange & " in order for your service to be uninterrupted."
But in the report, I need strPerson to show up in Bold and strDueDateRange to be underlined.
I have found some rich text activeX help on the web, but I can't seem to get it to work. But I would be glad to get this to work using any methods.
Thanks for any help out there.


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Sometimes, a poll is necessary. We're at one of those critical moments today.
I'm curious to hear what season is the best one for your small business. Do you have a restaurant on the beach that thrives in the summertime, when the clams are fresh and the weather is blazing? Or do you own a ski shop that muddles through the warmer months and starts crushing it as soon as the snow falls?
Nearly every business has an ideal season, and I'm interested to hear what yours is or are, depending on just how seasonal your company's products and services are.
Answer your poll at your leisure and feel free to expound further in the comments. Thanks, everyone!
[poll id="13″]
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Separate names with a comma.
Sign up and join the fastest growing Yuneec drone community.
Discussion in 'Typhoon H Discussion' started by BobW55, May 21, 2016.
The H GUI is back on the Yuneec web site.Downloads - Typhoon H
It says "Access Denied, not Allowed to View this Page" WTF!
It let me in but before I could grab my phone to download it gives me the same message now. Darn it all
Sucks! Guess they can't make their minds up ! LOL !
it is back up I just got it..........
I downloaded it this morning also , along with firmware updates .
New firmware or the original boxed one? Someone please explain to this old wounded DJI Veteran, what a GUI is and lead me to instructions on how to update firmware! I take it GUI must be a program that downloads the new firmware to you Yuneec's
LOL....you asked what i was afraid to....i guess its going to be a totally different learning curve coming from DJI....mine is coming wednesday...i will try and take my time...but i don't have much patience when it comes to reading manuals....
the tutorial video explains how to upgrade the typhoon using the sd card....ie...insert sd card into typhoon, power on transmitter, power on typhoon and perform update.....how do you update the transmitter itself? Use the sd card in the transmitter or via the typhoon's sd card?
GUI is Graphical User Interface
Link to firmware update procedure:
There is not a hell of alot to read, informative wise in general, but yes, do read it , as it is quite a different breed than a DJI, especially the controller and APP functions!, but you will fair well, I am confident. No one wants to answer my post on the "Mushroom Antenna" that came disconnected in un boxing, not by the threaded part that screws onto the ST16, but the swivel part that pushes into the screw on part!
Is the firmware new? or just the out of box one?
DC, a GUI is a graphic user interface. It is a program that will let you communicate with the H and make changes to the settings. Same as what you use on the Phantom. If you are running Windows 10, you might get a warning of potential harmful program being installed. This is because it is not properly signed by Microsoft, don't worry.
Yuneec firmware update instructions...
Nvrmnd...OutdoorGuys posted same link above.
I'm not sure what version firmware people have (I don't have mine yet).
The page seemed to have changed since I last looked at it:
Improvements to ultrasonic obstacle avoidance system performance.
Improvements to gimbal control in pan mode.
(Date: 5/19/2016)
When using the speed controller status test, make sure props are off. I don,t know if a warning appears but this can ruin your day.
I hope they get around to making a OSX version before mine gets here.
Is the date 5/19/2016 I see above the firmware date? if so I received mine on 20th , so this would definitively be new!
When you connect your H to the GUI it will tell you what version you have.
The instructions are for update using de SD Card. Can it be done directly using the GUI? If so, how (any instructions)?


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Moving to Harpenden(15 Posts)
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Results 1 to 5 of 15
Thread: Our Early Bird - Tabitha Faye
July 9th, 2013 02:54 PM #1Senior Member
- Join Date
- Apr 2013
- Posts
- 163
Our Early Bird - Tabitha Faye
She wasn't due until August 2nd, but little Tabitha Faye decided she couldn't wait any longer to arrive and popped out on July 5th. Very small but otherwise perfectly formed, Nico is absolutely smitten with his little sister.
Just wanted to come online and thank everyone on here that helped us decide on her name, and I'm sure I'll be back asking for help if we have any more children. For now though, I'm just enjoying spending time with my beautiful little family.My two bundles of love, Dominic Joseph and Tabitha Faye
July 9th, 2013 03:12 PM #3
Congratulations! I absolutely love her name!After two years of trying and one miscarriage,
Due July 2017 with #1!
July 10th, 2013 12:49 AM #5
I love the name Tabitha. Congratulations!Mom of James Daniel (13) William Joseph (12), Elise Marie (10), Zachary Allan (4), and George Thomas (2)
http://letterstoauntkay.com/ [making the blog private; PM me to subscribe]
TTC mid 2018? Or adopt?
Rose Audrey; Adele; Ida; Bridget Anna; Anne; Patricia 'Patsy'; Vera Colette; Sylvia Amy; Mary Kathleen; Linnea "Lindy"; Tabitha; Caroline; Dahlia; Celia; Rosemary Laura; Rosalind; Sally; Serena/Seri/Sarah; India
Franklin "Frankie" Maxwell; Theodore; Henry
July 10th, 2013 09:54 AM #7Senior Member
- Join Date
- Jun 2013
- Posts
- 3,293
Congratulations! You children have lovely names.
July 10th, 2013 02:00 PM #9


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Okay, guys, I'm bringing this to you a little late as I'm in the thick of TCA press tour madness, so hopefully this all makes sense. I'm a little worried Josh's dress might have been a hallucination of mine, but I'm sure someone will tell me if I'm really that sleep-deprived.
The designers, who all address Carolyn with that singsongy voice usually reserved for mean schoolteachers, get some good news from the stick figure — they're going to Paris! And they're getting a tour of the House of Valentino! And they're learning about couture for a couture challenge! And they get to buy fabric and Janssens & Janssens! And you get a car, and you get a car, and you get a car!
At the House of Valentino, the designers meet creative directors Maria Grazia Chiuri and Pierpaolo Picciolo, who are very polite and don't slam Josh's head against a wall for wearing clamdiggers. Chiuri and Picciolo reveal yet ANOTHER surprise — the designers all get to go to a Valentino show! Josh is so excited he's like a straight guy at a baseball game. Um, no, he's really not. Anyway, the challenge is to make a couture-inspired gown.
The designers take a dinner boat cruise along the Seine, which looks very pleasant when you don't have to eat rubber chicken with a bunch of tourists.
They head off to Janssens & Janssens, and they have 3,000 euros and one hour to shop. Josh somehow manages to find the tackiest, crappiest looking floral fabric in the whole store. And yes, he's buying it. There is no way he's surviving this challenge, is he?
Our intrepid designers go to the House of Valentino show and we get a glimpse of the runway, which looks crowded and fabulous at the same time. Then, it's time for the designers to hop on a plane back to New York and start working. I guess this is also a sleep deprivation challenge.
Joanna comes to visit. She likes Emilio's fabric, but hopes he doesn't go appliqué-crazy. She worries Uli's dress could be gladiator alligator meets Sicilian widow. Joanna admits Josh's fabric doesn't scream couture to her. But man, does it scream. Joanna is worried that Anthony Ryan will run out of time, as he's coming up with a new idea for his dress. C'mon, Anthony Ryan. You don't want to lose to a dress that looks like it's made with surplus fabric from a Michael's warehouse sale.
Runway time! Our judges are Georgina Chapman, Isaac Mizrahi and designer Cynthia Rowley.
This is the UGLIEST gown I can remember in the history of this show, the "Project Runway" franchise, and a fire sale at Sears. Words fail. Honestly, this is garish, horribly busy and looks cheap as hell. Josh has no taste. Yes, couture can be ugly and risky and weird, but this just looks crappy.
Anthony Ryan
A little funereal, but I guess this is more about the details. From a distance, it's not as impressive.
This is strong, but I think there are construction problems. The lining isn't working, and it seems as if the back was tacked on.
I wish he'd skipped the sleeves, but otherwise it's beautiful. The fabric was expensive and looks expensive, and this is beautifully made.
Emilio is first on the block. Isaac touches the fabric, then Cynthia runs up to touch it. Ooh, it feels like Paris! Isaac loves everything about it. But he'd love to see a tiny bit of ankle. Basically, everyone loves this dress. It's young, it's pretty, it's red!
Anthony Ryan's dress is also a hit. Isaac thinks the side is sexy in a very new way. Carolyn thinks it should breathe more, but admits it's beautiful.
Cynthia thinks Ul's dress is interesting, but she didn't like the nude lining. Carolyn thinks the back is blobby. Isaac thinks it looks expensive, but like expensive ready-to-wear, not couture.
Finally, we get to Josh's train wreck. Isaac thinks it doesn't completely work. Really? Georgina likes the idea of the lace and the floral print, but thinks the floral print is too small. Cynthia thinks it's a little ill-fitting. A little? Carolyn thinks it's a brave combination, and she likes it. Words fail. Really, people, this is a mess. I can understand the idea — it's the execution that's horrific.
The bottom two are Uli and Josh. There is no way Uli is going home, is she?
Emilio is the winner, I'm pretty sure. Nope, the winner is Anthony Ryan. Huh. Anyway, Emilio is safe.
Wait! There's one more challenge for Josh and Uli. What the? Carolyn tells them the late Alexander McQueen did this, so it must be good. They must deconstruct their gowns and create something new. In an hour. And they will do it on the runway. And they can use their scrap fabric. I like this idea, but Uli thinks it's like being in "The Hunger Games." The good news is she doesn't have to kill Josh, though I'd understand if she put his dress out of its misery.
Their two looks are fairly impressive — even Josh's dress works far better as ready-to-wear than couture. Georgina also thinks his deconstructed dress is better. Isaac thinks this is closer to his original intent. Cynthia likes it. Carolyn thinks the switch to the top is just beautiful.
Uli's turn. Georgina would wear the jacket. Cynthia loves that she made a dress from the lining everyone hated. Isaac finds this outfit weirdly influential.
Okay, judges. Enough with the endless challenges; let's pull off the Band-Aid. And the verdict is…
Uli is in, Josh is out. THANK GOODNESS. Josh has been trotting tacky down the runway (with some notable exceptions, like the military challenge) since day one. I can't believe he made it this far, but hey, he'll always have Paris.
Which dress did you think was the winner? Who do you think will take the grand prize? And did you like the deconstruction challenge?


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From unique designs to creating a masterpiece from outdated jewelry, we can create just about anything. Bring us your ideas or let us help you decide what inspires you. We'll walk you through the process step by step. Please see our GALLERY for more Custom Jewelry.
Here's our Custom Designed Jewelry Process
1) Bring in your old piece or new idea
2) We'll take your vision and sketch out a design by hand.
3) From that hand-sketch, we'll input the information into our CAD system and mold a wax replica.
4) We'll then cast your new piece of jewelry .
5) Then you can come to the store and pick up your beautiful piece of custom jewelry


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November 18, 2008 BY X
Two days ago we told you about the Nike x Michael Lau 1World Air Force 1 and the exhibition that Lau would be hosting at his gallery in Hong Kong. Now we have a preview of the Air Force 1 that Michael Lau worked on with Nike. It looks like the shoe will be a very high end and artistic version of a White/White Air Force 1. The graphic we saw on the flyer for the exhibition is applied in a quilted form to the entire upper of the shoe with the heel featuring a small graphic of some sort. Remember, Michael Lau looked to a psychiatric ward for inspiration for this pair of Air Force 1's, hence the shoe being dubbed the "Air Crazy Force 1". In addition to the AF1, Lau has also created a vinyl toy to accomodate the shoes. via Hypebeast // TOMM // HK-Kicks
More photos after the jump…
Filed under: Collaboration Nike Air Force 1s Upcoming Sneakers


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Of the four theme parks in Walt Disney World, many guests consider Epcot to be their favorite. This is thanks to the park's two unique halves which come together to form one amazing place. The front of Epcot is home to Future World where guests can enjoy thrills and attractions that merge nature with technology. World Showcase occupies the rear of Epcot and is comprised of eleven different pavilions which each celebrate a different country from around the world. With so much to see and enjoy in Epcot, guests might be a little stressed out trying to figure out what are the must dos. Here are twelve dos and don'ts for visiting Walt Disney World's Epcot.
1. Do Rope Drop —
One of the easiest ways to get the most out of day in Epcot is by arriving before the park even opens. By arriving for rope drop, guests ensure that they are some of the first let inside once the gates are open. There they can enjoy few crowds, low wait times, and quiet areas of the park.
2. Don't Do Spaceship Earth First —
Many guests automatically head straight to Spaceship Earth when entering Epcot since it is located just inside the main gate. This is a rookie mistake! Since so many guests head straight for the attraction, the line tends to bottleneck resulting in a rather lengthy wait time. Guests should not skip Spaceship Earth all together, but opt to return at a later point in the day when the crowds have eased up and the line is not as long.
3. Do Visit Soarin' Around the World Early —
Instead of heading to Spaceship Earth first, guests should go straight to The Land Pavilion. Located there on the first floor is one of the most popular attractions in Epcot. Soarin' Around the World brings guests on a thrilling hang gliding adventure over some of the most beautiful locations in the world. Since the attraction is so popular with guests, it tends to have long wait times throughout each day in Epcot. Guests who want to avoid spending lots of time waiting on line should head for Soarin' Around the World early on in the day when wait times are lower.
4. Do FastPass Frozen Ever After —
Perhaps the most popular attraction currently in Epcot is Frozen Ever After in the Norway Pavilion in World Showcase. The attraction has guests board boats and set sail for Arendelle where Anna and Elsa are hosting a summer celebration. With beautiful scenes and amazing audio-animatronics, every guest wants to enjoy a ride on Frozen Ever After resulting in long wait times. Guests who want to save time and not wait on a long line are smart to book a FastPass for the experience.
5. Don't FastPass Test Track Presented by Chevrolet —
Guests should actually avoid making a FastPass for another popular attraction in Epcot. Test Track Presented by Chevrolet can be found in Future World and invites guests to design their very own SIM cars and test them on the track in Efficiency, Power, Responsiveness, and Capability. The attraction is very popular with guests who want to see who can create the highest scoring car, and wait times tend to be very long on busy days in Epcot. Instead of waiting on a long stand by line or using a FastPass, guests should opt to enjoy Test Track Presented by Chevrolet by waiting on the single rider line. This line typically has a much shorter wait time for the same experience so long as guests don't mind being split up at the loading platform.
6. Do Watch the Fountain of Nations —
Located in the plaza behind Spaceship Earth is a massive fountain which comes to life several times each hour. The Fountain of Nations features water cannons which propel water into the air as though it were dancing. The Fountain of Nations puts on a beautiful show several times per hour and guests are smart to pause for a few moments to enjoy the wonderful music and sights.
For a no obligation, FREE Quote with new bookings contact our sponsor Magical Vacation Planner by calling: 1(407)442-0289
Or for a free no obligation quote with new bookings you can fill out the form by Clicking HERE!
7. Don't Skip the Underrated —
Future World is home to several thrilling attractions as well as a few underrated ones which are often overlooked by guests. Those enjoying time in Epcot should not skip Journey into Imagination with Figment, Living with the Land, or the Seas with Nemo and Friends. These attractions might not be the most popular, but they are definitely worth experiencing!
8. Do Enjoy Sunshine Seasons —
The Land Pavilion is home to a quick service dining location that many guests absolutely love. Sunshine Seasons is located on the lower level of the pavilion and serves up unique and fresh offerings that are often times grown right there in The Land. Guests who dine at the location for breakfast, lunch, or dinner can enjoy wonderful meals in an open air dining location.
9. Don't Rush World Showcase —
World Showcase is a truly massive area featuring eleven different pavilions. Each pavilion celebrates the history, architecture, culture, cuisine, entertainment, and traditions of a particular country from around the world. Since each pavilion has so many beautiful details to enjoy, guests should be sure to leave themselves plenty of time to simply wander and explore each pavilion of World Showcase.
10. Do Eat in World Showcase —
Each pavilion in World Showcase is home to at least one full service and one quick service dining location that serves up authentic food from that country. Guests who spend time in World Showcase should be sure to enjoy a meal there at some point and some of the most popular dining locations are Le Cellier Steakhouse, Nine Dragons Restaurant, La Cantina de San Angel, and Kringla Bakeri Og Kafe.
11. Don't Skip World Showcase's Attractions —
Several pavilions in World Showcase are also home to wonderful attractions which should not be skipped. We've listed Norway Pavilion's Frozen Ever After that we highly recommend a FastPass for. Guests should be sure to stop and enjoy the other, less popular attractions such as The Gran Fiesta Tour Starring the Three Caballeros in the Mexico Pavilions, Reflections of China in the China Pavilion, the American Adventure in the America Pavilion, Impressions de France in the France Pavilion, and O Canada! in the Canada Pavilion.
12. Do Stay for Illuminations: Reflections of Earth —
Each night in Epcot comes to a close with a showing of Illuminations: Reflections of Earth on World Showcase Lagoon. The show is a dramatic story that showcases how all people are united as one. Guests who stick around to watch the show can enjoy fireworks, beautiful music, pyrotechnics, laser lights, dancing water, and more. No night in Epcot is complete without enjoying Illuminations: Reflections of Earth!


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114, 976 Likes ¬Ý 5, 737 Dislikes¬Ý
"This season's most dazzling movie experience" – Joe McGovern, Entertainment Weekly
"Soaring and gorgeous" – Richard Lawson, Vanity Fair
"They don't make films like this anymore." – David Sexton, Evening Standard
Critics are raving about #LALALAND... Watch the NEW trailer and experience it in theaters this December!
La La Land – Now Playing In Theaters. Get tickets now: http://lions.gt/lalalandtickets
Starring Ryan Gosling, Emma Stone, John Legend, Rosemarie DeWitt, Finn Wittrock, Callie Hernandez, Sonoya Mizuno, Jessica Rothe, Tom Everett Scott and Josh Pence.
Download the LA LA LAND soundtrack now: http://smarturl.it/LaLaLandSoundtrack
Written and directed by Academy Award® nominee Damien Chazelle, LA LA LAND tells the story of Mia [Emma Stone], an aspiring actress, and Sebastian [Ryan Gosling], a dedicated jazz musician, who are struggling to make ends meet in a city known for crushing hopes and breaking hearts. Set in modern day Los Angeles, this original musical about everyday life explores the joy and pain of pursuing your dreams.
Summit Entertainment presents, an Imposter Pictures / Gilbert Films production, a Marc Platt production, a Damien Chazelle film.


text: I serve on the board at Easter Seals Southern Georgia and am proud to be a part of such a wonderful organization. Serving families of children/adults with disabilities is a pleasure. These families are so often overlooked and I applaud Easter Seals for helping those who can't help themselves. Our Easter Seals Southern Georgia in Albany, Georgia has a wonderful respite home called "Megan's House" named after my special child who died suddenly in 2003. We now have 2 other Megans' Houses in other areas in our region and one in another region. This respite home is just one of the many services that we provide for these families. We go the extra mile to help others. Again, I am proud to be a part of this wonderful organization.


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The Dalai Lama a … Pelicans fan?
When the New Orleans Hornets changed their team name a few months ago, they did so with the blessing of the NBA.
And now, it seems they've done so as well with the blessing of the Dalai Lama.
The Dalai Lama is in New Orleans this week for several speaking engagements, and during a break in his busy schedule, he was captured wearing a hat of the now New Orleans Pelicans.
Jason Gallagher of Baller.com spotted his holiness on Friday and posted a picture of him wearing the soon-to-be familiar red, blue and gold of the Pelicans to his Twitter page.
Now, maybe while he is in town, the Dalai Lama could bless the Pelicans chances of jumping up a few picks in the upcoming NBA lottery draft.
He might be a fan of the Pelicans, but there has been no confirmation if the Dalai Lama is a fan of Anthony Davis' unibrow.
FOX Sports Go


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Doodleganza: The Drawing Extravaganza
Chicago, IL 60611
The MCA continues its whimsical, hands-on art gathering that is not really an art class and not quite a party at Doodleganza: The Drawing Extravaganza. Taking place during Tuesday Evenings in the Café, this playful gathering of art-making games and exercises led by different Chicago-based artists is for the untrained and the skilled alike. January's featured artist, Ezra Claytan Daniels, returns for his final Doodleganza appearance of the season. Daniels is a writer and illustrator of critically acclaimed graphic novels, collaborative multi-media projects, and a line of fill-in-the-blanks comic-art greeting cards. Supplies are provided for Doodleganza participants.
Doodleganza: The Drawing Extravaganza takes place in Puck's Café, with a cash bar and light fair available for purchase. Every Tuesday, the MCA is free all day and open until 8 pm.


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Sarasota, FL (PressExposure) October 01, 2007 -- In today's real estate market, where Internet technology can define you and your brand, successful real estate brokers understand the importance of having a top-notch website to support and facilitate their agents in attracting new listings. If your agency's website is outdated and you're not keeping up with current Internet technologies, what plans do you have to upgrade your site such that your agents will no longer be at a disadvantage when they seek to get new listing contracts?
Important questions to ask yourself are:
- Am I leveraging interactive Google Maps to showcase my agent's listings on a single map? - Am I enabling my agents to post and manage, through a secure login, their listings, including property details and photos? - Am I randomly featuring and promoting my agent's listings on my agency's home page? - Is my website generating excitement and a sense of urgency amongst sellers to sign a listing agreement with my agents? - Is my website strengthening my agents' client relationships?
If your agency's current site lacks any of these benefits that may be keeping your agents from successfully signing new listing contracts, you should strongly consider the Pro Web Property Manger by Professional Web Designs. It's a cutting edge Internet real estate web site complete with Google mapping and the latest web 2.0 technology offering your prospects and agents a better web experience. To inquire about a hands-on, full-access demo of the Pro Web Property Manager, or to sign up for a free 30-day, no-strings attached, business-level demo, contact Professional Web Designs at 941-966-9087 or visit http://www.prowebdesigns.us.
Professional Web Designs 5342 Clark Road, STE 114 Sarasota, FL 34233 941-966-9087


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Milwaukee Brewers vs. Baltimore Orioles MLB Pick, Odds, Prediction 5/27/14
Baltimore Orioles (26-23) at Milwaukee Brewers (30-22)
MLB Baseball: Tuesday, May 27, 2014 at 8:10 pm (Miller Park)
Wei-Yin Chen (L) (5-2) (4.075) vs. Matt Garza (R) (2-4) (4.923)
The Line: Milwaukee Brewers -125 / Baltimore Orioles +115 --- Over/Under: 8 See the Latest Odds
TV: FS-Wisconsin, MASN2
The Milwaukee Brewers and the Baltimore Orioles face off on Tuesday at Miller Park for game two of their interleague series.
The Milwaukee Brewers let on get away on Monday as they blew a lead with two out in the ninth inning and then lost in extra innings hitting into a double play with a runner in scoring position. Khris Davis had four hits including a home run, Lyle Overbay hit a home run, and Jean Segura had two hits as the Brewers scored six runs on 11 hits. Starting pitcher Kyle Lohse allowed nine hits and four runs while striking out five over 6.2 innings to not factor in the decision as Francisco Rodriguez blew the save and Rob Wooten took the loss to fall to 1-2 for the season. For Tuesday's game the Brewers start Matt Garza who has two no decisions and a loss in his last three starts. For the season Garza has allowed 59 hits and 33 earned runs while striking out 47 over 60.1 innings for a 2-4 record and a 4.92 ERA.
USA TODAY Sports
The Baltimore Orioles never gave in on Monday and it paid off as they got the win in Milwaukee. Jonathan Schoop hit two home runs, J.J. Hardy had three hits, and Nick Markakis and Adam Jones each had two hits as the Orioles scored seven runs on 14 hits. Starting pitcher Chris Tillman allowed seven hits and six runs while striking out seven over 5.2 innings to not get a decision as Darren O'Day got the win and Zach Britton earned his third save. For Tuesday's game the Orioles start Wei-Yin Chen who has won five of his last six starts. For the season Chen has allowed 65 hits and 24 earned runs while striking out 34 over 53 innings for a 5-2 record and a 4.08 ERA.
Milwaukee is 4-2 in their last six home games, 7-4 against a team with a winning record, and 4-1 in Garza's last five starts as a favorite. Baltimore is 7-1 against the NL Central, 7-2 on the road against a team with a winning home record, and 6-2 in Chen's last eight starts.
I expect runs to be tough to come by here and my free pick is on the under. My stronger play is on the winning side and I will post that in the Premium Area as well as on the App.
Check out Sports Chat Place's New APP in the App Store including Mitch's App Attack Pick and Much More


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The lipid-lowering effect of niacin has been attributed to the inhibition of cAMP production in adipocytes, thereby inhibiting intracellular lipolysis and release of nonesterified fatty acids (NEFA) to the circulation. However, long-term niacin treatment leads to a normalization of plasma NEFA levels and induces insulin resistance, for which the underlying mechanisms are poorly understood. The current study addressed the effects of long-term niacin treatment on insulin-mediated inhibition of adipocyte lipolysis and focused on the regulation of cAMP levels. APOE*3-Leiden.CETP transgenic mice treated with niacin for 15 wk were subjected to an insulin tolerance test and showed whole body insulin resistance. Similarly, adipocytes isolated from niacin-treated mice were insulin resistant and, interestingly, exhibited an increased response to cAMP stimulation by 8Br-cAMP, β1- and β2-adrenergic stimulation. Gene expression analysis of the insulin and β-adrenergic pathways in adipose tissue indicated that all genes were downregulated, including the gene encoding the cAMP-degrading enzyme phosphodiesterase 3B (PDE3B). In line with this, we showed that insulin induced a lower PDE3B response in adipocytes isolated from niacin-treated mice. Inhibiting PDE3B with cilostazol increased lipolytic responsiveness to cAMP stimulation in adipocytes. These data show that long-term niacin treatment leads to a downregulation of PDE3B in adipocytes, which could explain part of the observed insulin resistance and the increased responsiveness to cAMP stimulation.
- adipose tissue
- lipolysis
- adenosine 3′,5′-cyclic monophosphate
- phosphodiesterases
niacin, also known as vitamin b3, is required for the synthesis of the cofactor nicotinamide adenine dinucleotide and is therefore essential for oxidative phosphorylation in energy metabolism (8). It has been used for more than 50 years for the treatment of dyslipidemias, since it decreases plasma triglycerides, low-density lipoprotein-cholesterol, and hepatic very low density lipoprotein (VLDL) triglyceride production (25), in addition to increasing high-density lipoprotein-cholesterol. Supplementation with niacin was shown to decrease risk of cardiovascular disease and atherosclerosis in dyslipidemic humans (1) and in dyslipidemic mouse models (23), using the APOE*3-Leiden.CETP cholesteryl ester transfer protein (CETP) transgenic female mouse.
The molecular mechanism by which niacin conveys its lipid-lowering effects is mostly unknown. The receptor for niacin, HCA2 (formerly known as GPR109A), has been shown to play an important role in acute antilipolytic effects (21) (10), but is not required for the long-term lipid-lowering effects (10). This receptor is expressed mostly in spleen, immune cells, and adipose tissue (20) where binding of niacin leads to the release of a Gα-inhibitory subunit that inhibits production of the secondary messenger cAMP by adenyl cyclase. Niacin is known to inhibit lipolysis in adipocytes via this reduction of cAMP (2), which leads to a reduced protein kinase A (PKA) activation and thus less phosphorylation and activation of the lipolytic enzyme hormone-sensitive lipase (HSL) (7). By inhibiting lipolysis, less nonesterified fatty acids (NEFAs) are released by adipocytes thus making less substrate available for VLDL-triglyceride production in the liver. Niacin may therefore lower lipid levels via its antilipolytic effect. However, during niacin administration the initial drop in NEFA and glycerol is followed within hours by a rebound and normalization of NEFA and glycerol levels and adipose tissue lipolysis rates (3, 10, 14, 24, 25).
In addition, long-term niacin administration leads to insulin resistance in liver, adipose, and muscle tissue (5, 17) for which the underlying mechanisms are poorly understood. In adipocytes, binding of insulin to its receptor leads to phosphorylation and activation of protein kinase B (PKB/Akt) and phosphodiesterase 3B (PDE3B), breaking down cAMP, which in turn reduces NEFA release from the cells.
We hypothesized that long-term niacin treatment modulates insulin signaling by acting at the level of PDE3B. Oh et al. (14) have previously shown that 24 h treatment with niacin induces insulin resistance and reduces expression of PDE3B in adipose tissue, hinting toward a possible role for PDE3B. In this study we functionally tested in APOE*3-Leiden.CETP transgenic female mice whether long-term niacin-induced downregulation of the enzyme PDE3B would lead to less PDE3B activity when stimulated by insulin, which would explain (part of) the observed insulin resistance in adipose tissue.
Animal model.
In contrast to wild-type mice, female APOE*3-Leiden.CETP mice (27) have a human-like lipoprotein profile that makes them exquisitely suited to test hypolipidemic drugs, such as niacin (23). This mouse model was bred at the Leiden University Medical Center. At age 15 ± 1 wk, mice were fed a western type diet (Diet T with 0.1% cholesterol, which consisted of 17 kcal/100 kcal protein, 43 kcal/100 kcal carbohydrate, and 41 kcal/100 kcal fat; AB Diets, Woerden, the Netherlands) with or without niacin (0.3% wt/wt; Sigma Aldrich, St. Louis, MO). Body weight was registered weekly. Animals were housed in a controlled environment (21°C, 40–50% humidity) with a daily 12:12-h photoperiod (0700–1900). Food and tap water were available ad libitum during the whole experiment. All experiments were performed after a 15-wk dietary intervention period. All animal experiments were performed in accordance with the regulations of Dutch law on animal welfare. The institutional ethics committee for animal procedures from the Leiden University Medical Center, Leiden, The Netherlands, approved the protocols.
Intraperitoneal insulin tolerance test.
Food was withdrawn from all animals at 0800 for a period of 6.5 h. Subsequently, all animals received a single intraperitoneal injection with insulin (0.2 U/kg; Novo-Nordisk, Bagsværd, Denmark), and blood samples were taken every 30 min for a period of 2 h. Blood samples were taken from the tail tip in chilled paraoxon-coated capillaries and placed on ice to prevent ex vivo lipolysis.
Organ collection.
All animals were euthanized, and organs were collected in the fed state between 0800 and 0930 unless otherwise indicated. Blood was collected by cardiac punction, and plasma was collected after centrifugation. Fresh subcutaneous (sWAT), gonadal (gWAT), and visceral (vWAT) white adipose tissue were harvested and used for determination of morphometry and lipolysis experiments as described below. In addition, a portion of the gWAT was frozen for qPCR and cAMP measurement. Liver and adrenal glands were harvested quantitatively and weighed before freezing. All tissues were stored at −80°C before further analysis.
Plasma and liver parameters.
Commercially available kits were used to determine plasma levels of triglycerides (1488872; Roche Molecular Biochemicals, Indianapolis, IL), total cholesterol (236691; Roche Molecular Biochemicals), phospholipids (Instruchemie, Delftzijl, The Netherlands), NEFAs (Wako Chemicals, Neuss, Germany), glucose (Accucheck, Roche, The Netherlands), and insulin (Crystal Chem, Downers Grove, IL), according to the manufacturer's instructions.
Adipocyte morphometry.
Adipose tissue from the gWAT, sWAT, and vWAT were minced and digested in 0.5 g/l collagenase in HEPES buffer (pH 7.4) with 20 g/l of dialyzed bovine serum albumin (BSA, fraction V; Sigma Aldrich) for 1 h at 37°C. The disaggregated WAT was filtered through a nylon mesh with a pore size of 236 μm. For the isolation of mature adipocytes, cells were obtained from the surface of the filtrate and washed several times. Cell size and volume of mature adipocytes were determined from micrographs (±1,000 cells/WAT sample) using image analysis software that was developed in-house in MATLAB (MathWorks, Natick, MA).
Lipolysis experiments in isolated adipocytes.
Adipocytes were incubated in DMEM-F-12 with 2% (wt/wt) BSA in 96-well plates with ∼10,000 adipocytes in 200 μl/well in the presence of 1) no additional reagents, 2) 10−3 M of the PDE3B-sensitive cAMP analog 8Bromo-cAMP, 3) 10−3 M 8Br-cAMP + 10−10 M insulin (Novo-Nordisk), 4) 10−6 M of the selective β2-adrenergic agonist terbutaline, or 5) 10−6 M of the selective β1-adrenergic agonist dobutamine. The wells of the adipocytes from niacin-treated mice contained 10−6 M niacin, whereas control adipocyte medium did not contain niacin. Basal lipolysis rates were determined in incubations without these reagents. PDE3B responsiveness in adipocytes from control and niacin-treated mice was assayed by lipolysis assay using the selective PDE3 inhibitor cilostazol (all obtained from Sigma Aldrich) under the following additional conditions: 6-8) 10−6, 10−5, or 10−4 M cilostazol or 9-11) 10−3 M 8Br-cAMP + 10−6, 10−5, or 10−4 M cilostazol. The adipocytes were incubated for 2 h at 37°C, after which 100 μl of lipolysis assay medium were frozen at −20°C. At the day of analysis, 10 μl of lipolysis assay medium were mixed with 100 μl of Free Glycerol Reagent (F6428; Sigma Aldrich) and 0.5 μl Amplex UltraRed Reagent (A36006; Invitrogen, Carlsbad, CA). After 10 min of incubation in the dark, the fluorescence was excited at 530 nm and measured at 590 nm on a Fluorometer (SpectraMAX Gemini; Molecular Devices).
Adipose tissue cAMP measurement.
cAMP concentrations were measured in 50 mg of gWAT, using the cAMP direct immunoassay kit (Biovision, Milpitas, CA).
Quantitative PCR.
RNA was isolated from gWAT using the Nucleospin RNA/Protein kit (MACHEREY-NAGEL, Düren, Germany). Subsequently, 1 μg of RNA was used for cDNA synthesis by iScript (Bio-Rad, Hercules, CA), which was purified by the Nucleospin Gel and PCR clean-up kit (Machery Nagel). Real-Time PCR was carried out on the IQ5 PCR machine (Bio-Rad) using the Sensimix SYBR Green RT-PCR mix (Quantace, London, UK) and QuantiTect SYBR Green RT-PCR mix (Qiagen, Venlo, the Netherlands). Target mRNA levels were normalized to glyceraldehyde-3-phosphate dehydrogenase mRNA levels. Primer sequences are listed in Table 1.
All data in Figs. 1–3 are represented as means ± SE. The mean of all data was tested between groups for differences by unpaired t-test for normally distributed data. A repeated-measures ANOVA was used when indicated. Threshold for significance was set at 5%. Tests were performed using GraphPad Prism version 5.00 for Windows (GraphPad Software, San Diego, CA).
Niacin does not alter body composition.
We have applied a humanized mouse model that has previously been shown (23) to react to niacin on plasma lipid parameters, atherosclerosis, and body weight in a similar manner as dyslipidemic humans. After 15 wk of niacin treatment body weight (Table 2) and weight gain (data not shown) did not differ between the niacin-treated and control mice. Adipose tissue depots were similar in weight, whereas the adrenal glands were heavier after niacin treatment (Table 2). Liver cholesterol content was significantly lower in niacin-treated mice (Table 2).
Niacin lowers plasma lipids, but increases fasting glucose and insulin.
Long-term niacin treatment resulted in the expected decrease of nonfasting plasma total cholesterol, triglycerides, and phospholipids (Table 2). In contrast to short-term niacin treatment, long-term niacin treatment did not lower NEFA levels (25) but slightly lowered glycerol levels compared with control mice (Table 2). Glucose and insulin concentrations were significantly higher after niacin treatment (Table 2), suggesting insulin resistance.
Niacin induces insulin resistance in vivo.
To verify the development of in vivo insulin resistance upon long-term niacin treatment we performed an insulin tolerance test. Insulin stimulates glucose uptake in muscle and adipose tissue and suppresses WAT glycerol release. After an intraperitoneal injection of insulin, blood was drawn and at indicated times, and glucose (Fig. 1A), glycerol (Fig. 1B), and insulin (Fig. 1C) were measured. Glucose levels dropped and insulin levels rose in both groups. Because glucose levels were already higher due to niacin treatment at time (t) = 0, the percentage change in glucose, glycerol, and insulin levels from the t = 0 values was calculated (data not shown). A repeated-measures ANOVA of the percentage change in insulin values indicated no significant effect of niacin, whereas a similar analysis of glucose values showed significant treatment differences. At 60 min, the percentage change in glucose was smaller for niacin-treated animals, indicating insulin resistance on a whole body level. Insulin induced a decrease in glycerol levels in the control group but failed to do so in the niacin-treated group, indicating adipose tissue insulin resistance.
Niacin reduces the antilipolytic effect of insulin in isolated adipocytes.
To study whether long-term niacin treatment also alters the response to insulin at the level of adipocyte lipolysis, we isolated gWAT adipocytes from control and niacin-treated mice and performed an ex vivo lipolysis assay. Basal lipolysis (i.e., unstimulated lipolysis) did not differ between the niacin-treated and control mice (Fig. 2A). 8Br-cAMP-stimulated glycerol release was higher in adipocytes from niacin-treated mice compared with control treatment. The antilipolytic effect of insulin, reflected by the percentage lipolysis suppression by insulin of 8Br-cAMP-stimulated lipolysis, was significantly smaller in the niacin-treated adipocytes (Fig. 2B). This implies a reduced insulin response of adipocytes from niacin-treated mice.
Niacin increases the lipolytic effect of β-adrenergic stimulation in isolated adipocytes.
Similar to testing the response of adipocyte lipolysis to inhibition by insulin, β1- and β2-adrenergic stimulation of gonadal adipocyte lipolysis was tested. Gonadal adipocytes from niacin-treated mice exhibited a greater response to both the β1-agonist dobutamine and the β2-agonist terbutaline, as well as the secondary lipolytic messenger 8Br-cAMP (Fig. 2A). These data show that lipolysis in niacin-treated adipocytes is more responsive to β-adrenergic and cAMP stimulation.
Niacin downregulates genes involved in both the insulin and the β-adrenergic signaling pathways that regulate lipolysis.
Expression of genes involved in the insulin and/or β-adrenergic pathways was analyzed by qPCR in gWAT. The niacin-treated adipose tissues showed a downregulation of the insulin signaling cascade: mRNA levels of the insulin receptor (Insr), insulin receptor substrate-1 (Irs1), and Pde3b were downregulated by 45, 97, and 53%, respectively, compared with control (Fig. 2C). Also mRNA levels of the lipolytic enzyme Hsl were downregulated (62%) in the niacin-treated mice. Furthermore, all β-adrenergic receptor genes were significantly downregulated. The β1-adrenoceptor (Adrb1) was downregulated by 68%, Adrb2 by 74%, and Adrb3 by 88%. The intracellular adrenergic adaptor β-arrestin1 (Arrb1) was also downregulated by 42%. These data indicate a decreased gene expression of the insulin and β-adrenergic receptors and their postreceptor signaling pathways to lipolysis.
Niacin-treated adipocytes display less PDE3B capacity.
Because the downregulation of the β-adrenoceptors was not consistent with the observed increased β-adrenergic response, we investigated whether the increased β-adrenergic response was the result of postreceptor signaling changes. Therefore we first tested the basal levels of the lipolytic postreceptor mediator cAMP. The cAMP concentration of nonfasted gWAT showed no difference after long-term niacin treatment (control: 19.9 ± 6.5, niacin: 21.6 ± 8.2 pmol/g adipose tissue, P = 0.63).
We then focused on the postreceptor enzyme PDE3B, catalyzing cAMP hydrolysis, whose gene expression was downregulated after niacin treatment. PDE3B is the most predominant PDE3 isoform in adipose tissue (12) that is activated by insulin. The role of PDE3B in lipolysis was characterized in gWAT adipocytes using the PDE3 selective inhibitor cilostazol (Fig. 3). Adding cilostazol to unstimulated adipocytes in basal medium did not increase lipolysis, indicating that under basal conditions PDE3B was not active. However, when 8Br-cAMP-stimulated adipocytes were subjected to increasing concentrations of cilostazol, there was a sharp rise in lipolysis. Therefore, inhibiting PDE3B capacity can increase the responsiveness to cAMP stimulation, e.g., by catecholamines. Furthermore, lipolysis of adipocytes from niacin-treated mice was stimulated to a lesser degree by 10−4 M cilostazol than control treated mice. A repeated-measures ANOVA indicated a significant interaction (P < 0.0001) between the concentration of cilostazol and the 8Br-cAMP-stimulated control/niacin adipocytes. This implied a lower responsiveness (slope) of PDE3B to its inhibitor in adipocytes from niacin-treated mice, independent of insulin signaling.
The present paper shows that long-term niacin induces insulin resistance in APOE*3-Leiden.CETP female transgenic mice fed a Western type diet. The insulin resistance by niacin has been shown before in dyslipidemic patients and is confirmed in our humanized mouse model, both in vivo on glucose and glycerol metabolism and ex vivo in isolated adipocytes on lipolysis. The niacin-induced insulin resistance was associated with a reduction in the expression of key insulin-signaling genes (i.e., Insr and Irs1) in WAT. This indicates that niacin downregulates the insulin signaling pathway at the transcriptional level, which led to the reduced antilipolytic effect of insulin. In contrast, gene expression of all β-adrenergic receptors, as well as Hsl and Arrb1, was downregulated in WAT, whereas an increased adrenergic lipolytic effect was observed. This might be because of desensitization after niacin-induced prolonged stress (9, 13, 14, 18, 26). Prolonged stress leads to increased adrenal gland size (22), also evident in our study. Decreased β-adrenoceptor gene expression combined with an increased β-adrenergic responsiveness suggest that the effects of niacin on β-adrenergic stimulation are the result of postreceptor signaling mechanisms that enhance cAMP stimulation and thus lipolysis.
Interestingly, 8Br-cAMP, which acts at the postreceptor level, induced lipolysis to a higher extent in niacin-treated mice, which strengthens the hypothesis that a postreceptor signaling mechanism is affected by niacin. The adipocyte lipolysis assays were not confounded by a difference in weight of the gWAT depots, nor in adipocyte mean cell volume (Table 1), which in itself might change responsiveness to reagents. It was shown by Oh et al. (14) that 24 h niacin infusion lowered the expression level of Pde3b in gWAT to a similar extent (−57%) compared with our study (−53%). PDE3B regulates intracellular cAMP levels and is the key enzyme involved in the antilipolytic action of insulin. Moreover, by modulating cAMP levels, PDE3B may interact with β-adrenergic signaling. Oh and coworkers suggested that the reduction in Pde3b may be an indirect effect of niacin that serves as a counterregulatory mechanism to increase the cellular cAMP-to-AMP ratio to maintain basal lipolytic rate. In the current paper we show that the reduction of expression of Pde3b in adipose tissue by niacin is accompanied by a reduced antilipolytic effect of insulin. We further show by using the selective PDE3 inhibitor cilostazol in an adipocyte lipolysis assay that the PDE3B responsiveness in adipocytes isolated from long-term niacin-treated mice was diminished. We also showed that cilostazol increased 8Br-cAMP-stimulated lipolysis in a concentration-dependent manner in adipocytes from control mice, whereas it did not have an effect on unstimulated cells.
These data suggest that in adipocytes PDE3B will only degrade cAMP when the lipolytic cascade is stimulated. These observations could explain the increased responsiveness to β-adrenergic or 8Br-cAMP stimulation in niacin-treated adipocytes. In the unstimulated basal condition PDE3B was not activated, which corresponds to the unchanged adipocyte lipolysis rate and basal adipose tissue cAMP levels between control and niacin-treated mice. In line with this, plasma NEFA levels did not differ between the groups at the start of the intraperitoneal insulin tolerance test, indicating that in vivo adipose lipolysis was also similar between the groups, despite decreased Pde3b expression.
We propose a molecular mechanism for long-term niacin treatment occurring in adipocytes (Fig. 4): lipolysis is regulated by HSL, which is controlled by cAMP levels. Production of cAMP can be stimulated via β-adrenergic pathways or inhibited by PDE3B, which is activated by the insulin-signaling cascade. PKA is activated by cAMP, which can activate PDE3B, creating a negative feedback loop (15, 16, 19) (Fig. 4). Long-term niacin treatment leads to downregulation of PDE3B (Fig. 4). This downregulation of PDE3B is also accompanied by a downregulation of the rest of the insulin signaling pathway, leading to reduced insulin responsiveness in the adipocyte. In addition, because the PDE3B responsiveness is smaller in adipocytes from niacin-treated mice, stimulated cAMP levels in the niacin-treated mice, after β-adrenergic stimulation, will be degraded to a lesser extent, leading to a net higher lipolysis.
In this study we have focused on adipocyte insulin response after long-term niacin treatment. However, the sequence of events leading up to adipocyte insulin resistance and decreased Pde3b expression remain unclear, as does the possible role of adipocyte insulin resistance in the development of whole body insulin resistance. Moreover, niacin has been shown to increase plasma adiponectin, an important insulin-sensitizing hormone. The increase in adiponectin plasma levels after niacin treatment was shown to correlate to the decrease in insulin resistance (6), indicating a possible compensatory insulin-sensitizing effect. We, however, did not detect an increase of adiponectin gene expression in gWAT after niacin treatment (data not shown). Whether niacin acutely interferes with the insulin-signaling cascade remains to be investigated, although PDE3B capacity was not affected in control adipocytes exposed to niacin for 2 h (data not shown). Choi et al. have shown a reduced phosphorylation of PKB/Akt in adipose tissue after 1.5 h infusion of niacin (4), which leads to a lower insulin response. Niacin thus seems to induce decreased adipocyte insulin responsiveness via more than one mechanism.
In conclusion, long-term niacin treatment resulted in insulin resistance and increased β-adrenergic responsiveness that may in part be explained by a niacin-induced downregulation of PDE3B.
This work was supported by grants from the Center of Medical Systems Biology, the Netherlands Consortium for Systems Biology established by The Netherlands Genomics Initiative/Netherlands Organization for Scientific Research. M. R. Boon is supported by the Board of Directors of the Leiden University Medical Center. P. C. N. Rensen is Established Investigator of the Netherlands Heart Foundation (NHS2009T038).
The authors declare no conflicts of interest, financial or otherwise.
Author contributions: M.M.H., S.A.v.d.B., and V.v.H. conception and design of research; M.M.H., S.A.v.d.B., A.C.P., M.R.B., and V.v.H. performed experiments; M.M.H., S.A.v.d.B., A.C.P., J.V.K., M.R.B., and V.v.H. analyzed data; M.M.H., S.A.v.d.B., and V.v.H. interpreted results of experiments; M.M.H. and S.A.v.d.B. prepared figures; M.M.H., S.A.v.d.B., and V.v.H. drafted manuscript; M.M.H., S.A.v.d.B., J.V.K., M.R.B., L.M.H., P.C.N.R., K.W.v.D., and V.v.H. edited and revised manuscript; M.M.H., S.A.v.d.B., A.C.P., J.V.K., M.R.B., L.M.H., P.C.N.R., K.W.v.D., and V.v.H. approved final version of manuscript.
We thank S. J. M. van der Tuin for discussions on gene expression analysis.
Present address of S. A. A. van den Berg: Department of Laboratory for Clinical Chemistry & Hematology, Amphia Hospital, Breda, The Netherlands.
- Copyright © 2014 the American Physiological Society


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Results 1 to 8 of 8
07-30-14, 09:54 #1Registered User
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- Jul 2014
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Unanswered: Text is stored in field with as Integer ???
Hello, I wasn't able to google anything regarding this topic, so here I am
However I inherited a complex database. I have a table with the field "Name". The field is populated with names like "John Nowak". Surprisingly, the field "Name" is a Number, Long integer, when I'm looking into the design view of the table.
Now the problem
- query using a parameter for the field "Name" - not working due to the format
- combo box in a new form - displaying the name "John Nowak" as 50123 or something like that
- filter criteria in the query [Name]="John Nowak" - not working
- trying to convert the field to a text format and text string, all string functions return numbers, like 52143, 45895 etc. instead of names
I'm trying to create a combo box, where customer would select his name, but I'm not able to do anything with the format. Could you please suggest anything? Is there a way to create a parameter criteria for a query that would take into consideration exactly the string that we see in the field, and not its background format? The parameter "John Nowak" returns no records at the moment.
I've found tons of "how to convert number to text", but nothing like "how to convert number to text, if the number is actually displayed as text string"
Thank you.
07-30-14, 10:36 #2Registered User
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A field set as long CANNOT store text. If it is showing this, the table is corrupted.
07-30-14, 11:48 #3Moderator
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If your Field name is actually Name that may be the root of the problem! Name is a Reserved Word, in Access, and they should never be used as the names of anything! And of all the Reserved Words, I can not imagine one that is more likely to confuse the Access Gnomes than Name!
I doubt seriously that you're going to be able to do any kind of conversion that's going to resolve this. When looking at the Table in Datasheet View, what do you see in the Field?
Linq ;0)>Hope this helps!
The problem with making anything foolproof...is that fools are so darn ingenious!
All posts/responses based on Access 2003/2007
07-30-14, 13:26 #4Registered User
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If it's displaying name but storing number, I'd guess it's a lookup field:
The Access Web - The Evils of Lookup Fields in TablesPaul
07-31-14, 03:56 #5Registered User
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Thank you for replies.
To Missinglinq:
The field name is not a problem, as its exact name is "Customer Name", I'm sorry for the confusion.
To pbaldy: I checked the link you provided and then the field and - unfortunately - yes, this is the case of a lookup field. It is pulling the names from another query and the field itself is working as a combo box within the table (where you can select whichever name you want).
So as I understood - there is no way to filter values or use parameter for a lookup field? I'm trying to setup a form, where customer would be prompted to select his name from combo box/parameter box first, so that he can see only those records that are assigned to his name, returned by the query (query which is pulling data from the table where I have the lookup field "Name"). Is there any way how to do this?
07-31-14, 04:30 #6Jaded Developer
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use a table NOT an Access lookup field. the Lookup field works OK for some tasks. but its really aimed at simple applications. it quickly hits problems such as you have found.
hence why I strongly recommend that you don't use itI'd rather be riding on the Tiger 800 or the Norton
07-31-14, 04:41 #7Registered User
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But -
I have a table with the lookup field - it is filled with new data whenever customer fills out a form.
Then I have a table with the list of all customers.
I cannot match these two tables, as their formats are, of course, Text vs. Number.
So basically I cannot do anything in order to create a filter based on customer name, which would restrict the list of the table with the lookup field?
07-31-14, 07:16 #8Jaded Developer
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yes you can
use a table.....
do the job properlyI'd rather be riding on the Tiger 800 or the Norton


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blue and white speckled oval shape was told is adipex but inprint is not found is it generic or is it not what it was mark?
What is this pill - with 'lci 1445' imprint?
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Answers (2)
This pill is Phentermine HCl 37.5mg
Imprint Code LCI 1445
Blue oblong scored tablet
Put out by Lannett.
More info at https://www.drugs.com/phentermine.html
It's called adipex .
Pretty much all it does is speed you up .
Alot of people use it to lose weight .
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I have found a pill with lci 1445 is it for weight lossor for adhd?
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March 19, 2013 - Central Hockey League (CHL)
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GLENDALE, AZ (March 19, 2013) - The Central Hockey League (CHL) announced today several suspension stemming from this past weekend.
Allen Americans forward Kale Kerbashian was suspended indefinitely on Sunday awaiting further review of his spearing incident in Saturday's game in Fort Worth. The final determination is a three (3) game suspension which includes Sunday's game versus Fort Worth and will also include Tuesday's game versus Wichita (Mar. 19) and Friday's game in Wichita (Mar. 22).
Wichita Thunder forward R.G. Flath has been suspended two (2) games for his Physical Abuse of Official penalty in overtime of Saturday's game in Arizona. Flath was observed to shoot a puck in the direction of the on-ice officials. He will miss Tuesday's game in Allen (Mar. 19) and Friday's game at home versus Allen (Mar. 22).
Missouri Mavericks Head Coach Scott Hillman has been suspended one (1) game for throwing items on the ice in Sunday's game in Quad City. He will miss Tuesday's game in Bloomington (Mar. 19).
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Central Hockey League Stories from March 19, 2013
- Rush Net Four Unanswered En Route to 5-2 Win over Oilers - Rapid City Rush
- Robinson Nets Game-Winner in 4-3 Win over Allen - Wichita Thunder
- Postseason Bound: Denver Earns Playoff Spot in 4-3 OT Loss - Denver Cutthroats
- Mallards Clinch Playoff Berth with Overtime Win - Quad City Mallards
- Oilers Fall to Rush in Series Finale - Tulsa Oilers
- Mavericks Battle Back to Beat Blaze, 4-2 - Missouri Mavericks
- Blaze Eliminated in Battle with Mavericks - Bloomington Blaze
- Sundogs Clinch Playoff Spot - Arizona Sundogs
- Mavericks Playoff Tickets on Sale Thursday - Missouri Mavericks
- Murray Named Oakley Central Hockey League Goaltender of the Week - Quad City Mallards
- Quad City's John Murray Named Oakley CHL Goaltender of the Week - CHL
- Wight Selected as CHL Man of the Year - Wichita Thunder
- Wichita's Travis Wight Named CHL Man of the Year - CHL
- Central Hockey League Announces Suspensions - CHL
- Fly Away to See the Americans in the Post-Season - Allen Americans


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Graham Fletcher has worked in education for over ten years as a classroom teacher, math coach, and currently as a district math specialist.
He graduated from the University of Georgia where he earned his specialist degree in Math Education. Graham's passion for conceptual understanding through problem-based lessons has led him to present internationally and throughout the United States.
He continues to be an advocate for best practice and a change agent for elementary mathematics.
Twitter: @gfletchy
Google+: Graham Fletcher
"I try to surround myself around people who are smarter than me. I try to make myself vulnerable. All of us are smarter than one of us." – Graham Fletcher