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A Study of Repeat Dosing of OROS® Methylphenidate Hydrochloride (CONCERTA®) and Immediate Release Methylphenidate Hydrochloride in Healthy Adults
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
This is a double-blind, randomized, placebo-controlled, five-period crossover study to examine the likability of a repeated administration of immediate release methylphenidate hydrochloride (IR-MPH 40 mg) and OROS®-MPH (CONCERTA® 72 mg) in healthy adults. Hypotheses are as follows:
- Hypothesis 1: the subjective feelings of detection and likeability will be greater for periods of IR-MPH administration than after OROS-MPH administration irregardless of sequence;
- Hypothesis 2: the greater ratings of feelings of detection and likeability will be associated with the periods of most rapid change in plasma d-MPH and not with the magnitude of plasma d-MPH concentration (other than the OROS-MPH to IR-MPH condition in which they coincide), and
- Hypothesis 3: the subjective feelings of dislike will be greatest for the two conditions in which IR-MPH is the second condition.
|Drug: OROS-Methylphenidate Drug: Immediate Release Methylphenidate Drug: Placebo
|Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
|Official Title:
|A Double-blind, Randomized, Placebo-controlled, Crossover Study of Repeat Dosing of OROS® Methylphenidate Hydrochloride (CONCERTA®) and Immediate Release Methylphenidate Hydrochloride in Healthy Adults
- Peak Plasma Concentration of d-Methylphenidate [ Time Frame: 4 hours ]Objective measure determined from blood samples, measured 4 hours after the dose
|Study Start Date:
|January 2006
|Study Completion Date:
|June 2007
|Primary Completion Date:
|June 2007 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: OROS-MPH + OROS-MPH
OROS-Methylphenidate Will be administered during the first part of the day, and again during the separate part of the day.
Drug: OROS-Methylphenidate
Each dose of OROS MPH will be 72 mg which will be supplied as two 36 mg overencapsulated capsules
Other Names:
Experimental: IR MPH + IR MPH
Immediate release methylphenidate will be administered in the first part of the day followed by Immediate release methylphenidate in the second part of the day.
Drug: Immediate Release Methylphenidate
Each dose of IR MPH will be 40 mg which will be supplied as two 20 mg overencapsulated capsules
Other Names:
Placebo Comparator: Plabebo + Placebo
Placebo will be administered during the first part of the day, and again during the second part of the day.
Drug: Placebo
Placebo will be administered during the first part of the day, and again during the second part of the day.
Experimental: OROS MPH+ IR MPH
Concerta will be administered in the first part of the day, followed by Immediate Release Methylphenidate in the second part of the day.
Drug: OROS-Methylphenidate
Each dose of OROS MPH will be 72 mg which will be supplied as two 36 mg overencapsulated capsules
Other Names:Drug: Immediate Release Methylphenidate
Each dose of IR MPH will be 40 mg which will be supplied as two 20 mg overencapsulated capsules
Other Names:
Experimental: IR MPH + OROS MPH
Immediate release Methylphenidate will be administered in the first part of the day, followed by Concerta in the second part of the day
Drug: OROS-Methylphenidate
Each dose of OROS MPH will be 72 mg which will be supplied as two 36 mg overencapsulated capsules
Other Names:Drug: Immediate Release Methylphenidate
Each dose of IR MPH will be 40 mg which will be supplied as two 20 mg overencapsulated capsules
Other Names:
Detailed Description:
The main goal of this study is to assess whether the abuse liability potential of delayed, repeated administrations of different formulations of MPH is moderated by the oral delivery system in which a delivery system with slower onset may be safer than one with more rapid early release. To this end, the investigators will compare repeated administration of orally administered, therapeutic doses of a short (IR-MPH) and a long-acting formulation of MPH (OROS-MPH) in the following areas:
- pharmacokinetic profile of MPH assessing rate of onset of MPH action (indexed through change in plasma level) and
- abuse liability (indexed through detection and likeability).
The investigators will test all combinations of initial administration and then delayed (repeated) administration of the two formulations: IR-MPH to IR-MPH; IR-MPH to OROS-MPH; OROS-MPH to IR-MPH; OROS-MPH to OROS-MPH, and placebo to placebo.
|Ages Eligible for Study:
|18 Years to 45 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Males or non-pregnant, non-lactating females. With the exception of women who have been post-menopausal for a minimum of 12 months prior to screening and those who have undergone hysterectomy or bilateral oophorectomy, all female subjects must have a negative urine pregnancy test at both screening and at each admission to the research unit. All male and female subjects must have used a medically acceptable form of birth control for at least one month prior to screening and be willing to continue use during the study. Medically acceptable forms of birth control include abstinence, hormonal contraceptives, diaphragm with spermicide, condom with spermicide, intrauterine device, or surgical sterilization (including vasectomy of male partner[s]).
- Eighteen (18) to 45 years of age, inclusive
- Based on medical history, limited physical examination (neurologic and cardiac) and/or lab results, are considered healthy and free of any conditions that may interfere with participation in the study. Any abnormalities at screening on results of electrocardiogram (ECG) or any laboratory test must be determined to be not clinically significant by an investigator.
- Agree to not use prescription stimulants (except for the study medication) during the study
- Have venous access sufficient for blood sampling as determined by clinical examination
- Weigh at least 100 pounds at screening
- Agree and are available to return to the study center for five full-day (approximately 18 hours) study visits held five to 30 days apart within a 22-week period, and willing to complete all protocol-specified assessments.
- Able to read and comprehend English
Exclusion Criteria:
- Marked anxiety, tension, and agitation since the drug may aggravate these symptoms
- Known hypersensitivity to methylphenidate or other components of Concerta or Ritalin
- Subjects with glaucoma
- Motor tics or with a family history or diagnosis of Tourette's syndrome
- Treated with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuation of treatment with MAOIs
- Presence or history of any medically diagnosed, clinically significant Axis I psychiatric disorder (including substance use disorders, bipolar disorder, any psychotic disorder)
Scores of Baseline Scales:
- Hamilton Depression Scale > 17 (out of a possible 67 on the 21-item scale) (Hamilton 1960)
- Beck Depression Inventory > 19 (out of a possible 63 on the 21-item scale) (Beck et al 1961)
- Hamilton Anxiety Scale > 21 (out of a possible 56 on the 14-item scale) (Hamilton 1959)
- Any clinically significant chronic disease or unstable medical abnormality by history or physical examination, including hypertension, hyperthyroidism, a seizure disorder, history of myocardial infarction or stroke, or history of cardiac arrhythmia or heart murmur (other than uncomplicated mitral valve prolapse)
Clinically significant abnormal baseline laboratory values which include the following:
- Values > 20% above the upper range of the laboratory standard of a basic metabolic screen and complete blood count
- Exclusionary blood pressure > 140 (systolic) and 90 (diastolic).
- Exclusionary ECG parameters: QTC > 460 msec, QRS > 120 msec, and PR > 200 msec. Subjects having ECG evidence of ischemia or arrhythmia as reviewed by an independent cardiologist
Currently taking or require any of the following medications:
- Clonidine or other alpha-2 adrenergic receptor agonists
- Tricyclic antidepressants
- Selective serotonin reuptake inhibitors (SSRIs)
- Theophylline
- Coumarin anticoagulants
- Anticonvulsants
- Prescription stimulants
- Have taken an SSRI in the 35 days before initiation of the study medication
- Currently physically dependent on benzodiazepines, opiates or alcohol as determined by clinical evaluation or positive urine drug screen at screening
- Preexisting severe gastrointestinal narrowing (pathologic or iatrogenic, for example: small bowel inflammatory disease, "short gut" syndrome due to adhesions or decreased transit time, past history of peritonitis, cystic fibrosis, chronic intestinal pseudoabsorption, or Meckel's diverticulum)
- Unable to swallow the study medication whole
- Have had a significant blood loss (> 500 mL) or donated blood in the 30 days preceding dosing
- Have a positive urine drug screen at screening
- Have taken an investigational medication or product within the past 30 days
- Have taken prescription medications (with the exception of birth control methods) within seven days of screening or is anticipated to need any medications, over-the-counter products (other than acetaminophen), or herbal supplements during the study
Please refer to this study by its ClinicalTrials.gov identifier: NCT00302458
|United States, Massachusetts
|Massachusetts General Hospital
|Boston, Massachusetts, United States, 02114
|Principal Investigator:
|Thomas Spencer, MD
|Massachusetts General Hospital
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Thomas J. Spencer, MD, Assistant Director of the Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital
|ClinicalTrials.gov Identifier:
|NCT00302458 History of Changes
|Other Study ID Numbers:
|Study First Received:
|March 13, 2006
|Results First Received:
|November 18, 2013
|Last Updated:
|February 1, 2016
Keywords provided by Thomas J. Spencer, MD, Massachusetts General Hospital:
healthy volunteers
Additional relevant MeSH terms:
Central Nervous System Stimulants
Physiological Effects of Drugs
Dopamine Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Dopamine Agents
Neurotransmitter Agents
ClinicalTrials.gov processed this record on September 21, 2017


text:
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text:
The destruction of America is in our National Debt. In just 7 years our debt will top $25 trillion dollars. The interest on that could be $1.5 trillion if our credit rating continues to drop. America only took in $2.3 Trillion in tax dollars last year. That is the economic destruction of America, as we know it.
Before we can reduce the debt, we must stop the bleeding and balance the budget. The business approach to stop the bleeding in a company is to first consolidate all functions of the company under strong department leaders. These department leaders are instructed to cut their personnel by twenty percent. They are then charged with making sure everything that needs to be done, is done promptly, efficiently and thoroughly. If they cannot do it, we get someone who can, for the survival of the company and its good employees.
Applying these business principles to our bloated bureaucratic government:
1. Consolidate all functions of the Executive Branch under the appropriate Cabinet or Department. All Czar positions are eliminated with necessary functions going to the appropriate Departments. EPA goes to the Department of Interior. Homeland Security goes back to Justice and Defense. Education goes back to the States, with the DOJ enforcing our educational laws. Department of Energy is eliminated, with the NRC going under Interior or Health and Human Services.
2. Employ the most qualified people to run the departments and pay them well. Instruct them to develop a plan to cut 20% from their department and still accomplish the needed task. If they cannot or will not do this, then we move them and hire a new department head who will.
3. Charge those Department heads to revise the process of their Departments to accomplish their needed tasks, while coordinating their efforts with all other departments. If they cannot work together to streamline our government, then they are not effective and must be removed.
Consolidate – Cut – Charge! This will not only balance the budget but will also provide a much more efficient, effective and professional government to serve We The People! This works for business and it will work in government. After all, Government IS business with to much politics in it.


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Albums - M #11
Ma Philosophie (1 Songs) by Amel Bent
Ma Philosophie..
Ma Pomme (9 Songs) by Maurice Chevalier
Quand Un Vicomte a S est Pass Un Dimanche Chapeau de Zozo..
Maps For A Voyage (2 Songs) by Neo
Absolution Record Straight..
Maquetas 2005 (1 Songs) by El Pirata
Los Motores..
Maquina De Sangre (11 Songs) by Los Piojos
Cancion De Cuna Como Ali No Pares..
Mar (1 Songs) by Leo Garcia
El Amor Es Ciego..
Mar De Copas (5 Songs) by Mar De Copas
Fugitivo H roe Del Delito A Tu Coraz n..
Mar De Copas En Vivo (1 Songs) by Mar De Copas
Mar De Dioses (13 Songs) by Sphinx
I Want It All Mentiras Miseria Mundana..
Maraca (2 Songs) by Sleater-Kinney
You re No Rock N Roll Fun Maraca..
Maracatus, Batuques E Ladeiras (3 Songs) by Alceu Valença
P talas Valores Do Passado Diabo louro..
Marathon (6 Songs) by Santana
Hard Times Lightning in the Sky Stay Beside Me..
Marauder (8 Songs) by Blackfoot
Diary Of A Workingman Dry County Payin For It..
Maraviya (2 Songs) by Buitres
Ojos Rojos Llorando Por Vos..
Marbles (16 Songs) by Marillion
Marbles II You re Gone The Only Unforgivable Thing..
Marbool (1 Songs) by Orphaned Land
The Storm Still Rages Inside- Part..
Marc Anthony (15 Songs) by Marc Anthony
When I Dream At Night Dimelo I Need To Know My Baby You..
Marc Cohn (11 Songs) by Marc Cohn
Ways True Companion Silver Thunderbird..
March 16-20 1992 (14 Songs) by Uncle Tupelo
Wait Up Lilli Schull Criminals..
March March Alive (11 Songs) by *** Aggression
Lock us away Under Smash the State..
March March Along (7 Songs) by *** Aggression
March March Along Fed Up Life on the road..
March Of The Pigs (1 Songs) by Nine Inch Nails
All The Pigs All Lined Up..
March Of The Saint (9 Songs) by Armored Saint
March Of The Saint Envy Mutiny on the World..
March Of The Zapotec (3 Songs) by Beirut
La Llorona The Shrew The Akara..
March On Electric Chidren (1 Songs) by The Blood Brothers
American Vultures..
March On Electric Children (8 Songs) by The Blood Brothers
Birth Skin Death Leather Siamese Gun Mr. Electric Ocean..
March Or Die (1 Songs) by Motorhead
I Ain t No Nice Guy..
March To Fuzz (33 Songs) by Mudhoney
Here comes sickness This gift Suck you dry..
Marchef W Butonierce (12 Songs) by Pidzama ***
Zabilem Go Chlopcy Ida Na Wojne Pryszcze..
Marcher Dans Le Sable (2 Songs) by Gerald De Palmas
Regarde-Moi Bien En Face Trop Tard..
Marchin Already (1 Songs) by Ocean Colour Scene
Foxy s Folk Faced..
Marchin' Already (3 Songs) by Ocean Colour Scene
Better Day It s A Beautiful Thing Hundred Mile High City..
Marching Mystery (2 Songs) by Dougie MacLean
Broken Wings Marching Mystery..
Marching Out (11 Songs) by Yngwie Malmsteen
Disciples Of Hell Marching Out I ll See The Light Tonight..
Marching To Mars (11 Songs) by Sammy Hagar
Would You Do It For Free Marching To Mars The Yogi s So High I m Stoned..
Marco (3 Songs) by Marco Borsato
Waarom Nou Jij Hij Had Het Willen Zeggen Dit Was Je Leven..
Marco Masini (1 Songs) by Marco Masini
Ci Vorrebbe Il Mare..
Marcus Garvey (8 Songs) by Burning Spear
Resting Place Marcus Garvey Tradition..
Marcy Playground (12 Songs) by Marcy Playground
Sherry Fraser Saint Joe On The School Bus Dog And His Master..
Browse by albums
All lyrics are property and copyright of their respective authors, artists and labels. All lyrics provided for educational purposes only.
On LyricsInfo.org you can find lyrics, album names, artist overviews, history, current and past members of bands, listen and watch videos.


text: PoliticsText: US assessment of Syrian chemical attack Unclassified report from US government outlines conclusions about alleged chemical weapons attack in Damascus suburbs. 30 Aug 2013 18:13 GMT | Politics, Middle East, US & Canada, Syria, United States Embedded below is the text of a four-page document released by the White House on August 30, 2013, outlining the US government's conclusions that "the Syrian government carried out a chemical weapons attack in the Damascus suburbs on August 21". The document was released to help make the case for possible US-led military action against Syria. Source: Al Jazeera


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LEHI — Real Salt Lake's return to its winning ways the past two weeks isn't a coincidence.
Following a crushing 3-2 defeat at Houston on Aug. 20, which was the team's fourth loss in five outings, coach Jason Kreis used the next week of practice to refocus the players defensively.
Without giving away too many tactical secrets, Kreis said, "It's all kinds of details about how we defend and where we defend, and what kind of effort and commitment that takes from every player on the field."
He stressed the importance of dead ball situations and communication throughout the game.
The recommitment defensively paid off in a big way at Chivas USA two weeks ago as RSL won despite playing down a man for more than an hour. Last week, visiting Philadelphia was never allowed to settle into any type of rhythm because of RSL's constant defensive pressure.
The return of Jamison Olave to the starting lineup no doubt made a difference, but so many other tiny tactical nuances were just as important.
"The coaches kind of brought us back and went over what we did in the preseason and the beginning of the season that got us where we were and throughout the last season," said Andy Williams. "Once you work hard on defense, and work hard on denying teams goal scoring opportunities, our chances will come and our opportunities will come and our soccer were come."
Williams said communication between the players on the field was lacking during RSL's disappointing 1-4 stretch, which he blamed partly on differing lineups from week to week.
"I don't think we've had too many back-to-back same lineups throughout the season and that's kind of been affecting us," said Williams.
That will likely continue to be the case as players return from their respective national teams and injuries over the coming weeks. It's a big reason why RSL will need to maintain that defensive focus from here on out if it hopes to be a factor in the playoffs.
BACKLINE QUESTION MARKS: RSL defender Robbie Russell, who was subbed off late in last week's win over Philadelphia because of back spasms, trained with the team on Wednesday but remains questionable for Saturday's game at Seattle.
With limited options behind him though, Russell will likely need to play through the pain.
"We've asked him to probably play through some things here in the last week or so that in a different part of the season we would've said yeah we'll protect you," said Kreis.
Until Chris Wingert returns from his broken wrist or the coaching staff feels comfortable enough to start newcomer Blake Wagner, Russell will likely start.
RELATIVELY FRESH:Kyle Beckerman returned to Utah on Wednesday night after suiting up for the U.S. National Team for a friendly in Belgium on Tuesday.
Despite the fatigue associated with the three-and-a-half-day round-trip jaunt, Beckerman should still be relatively fresh against Seattle.
Beckerman only played in the second half of the United States' 1-0 loss at Belgium, which was a welcome sight for Kreis, who expected Beckerman to perhaps play the full 90 minutes.
RESERVE SETBACK: The RSL Reserves conceded a pair of goals in the opening 25 minutes at Chicago on Tuesday morning in falling to the Fire 2-0. The loss dropped the team's record to 2-5 in the Reserve League season with three matches remaining.
Ned Grabavoy played the first 45 minutes against Chicago as he continues his road back from a groin injury. After missing a month with the injury, Grabavoy finally returned to field last Saturday against Philadelphia, entering the game as a substitute for the final 17 minutes.
Email: firstname.lastname@example.com


text:
Ricardo Lent
Ricardo Lent is a Research Fellow at the Intelligent Systems and Networks Group at the Imperial College London. He holds M.S. and Ph.D. degrees in computer science from the University of Central Florida. His prior experience includes work as a Network Engineer for industry and as a Visiting Assistant Professor at the University of Central Florida. His research is focused on autonomic and self-aware networks, such as the cognitive packet network both on wired and mobile ad hoc domains. He is the Author of some thirty papers in top journals and conferences including the Proceedings of the IEEE, and he regularly teaches experimental packet network design and performance measurement at the undergraduate and postgraduate level. Dr. Lent has participated in many UK and EU funded research projects as a Postdoctoral Fellow and as a Co-PI, including UK EPSRC Self-Aware Networks and Quality of Service, EU FP6 CASCADAS, EU FP7 DIESIS, EU FP7 Fit4Green.
Biography Updated on 17 October 2011


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ciePhoto app
cieTrade Systems, Inc.http://www.cietrade.com
cieTrade's ciePhoto app for the iPod, iPhone and iPad is designed to help recyclers save time and money by expediting the capture and documentation of photos for export shipments and the handling of quality issues.
According to cieTrade, ciePhoto replaces the use of a digital camera to take photos by automatically uploading images directly into the users' cieTrade recycling software and matching them to their corresponding export container or received load.
"The app eliminates hours of work that is normally spent manually downloading, organizing and matching photos to loads," explains David Haber, managing partner at cieTrade. Haber says ciePhoto also helps reduce the number of lost photos since images are uploaded from the device immediately after they are taken, and unmatched photos can also be tracked.
The app works by allowing one or more photos to be taken for each inbound trailer or outbound shipping container which are then saved to the "cloud" with an identifying load or container number. All photos are automatically date-stamped and resized for export customs or CCIC compliance, the company says. ciePhoto then attaches the images to their corresponding loads in the cieTrade Recycling Software system where booking documentation can be submitted to customers or claims notices sent to suppliers.
The ciePhoto app will work with either a wifi or cellular network connection. It can also operate without an internet connection, allowing loads to be submitted at a later time.
Although ciePhoto is currently exclusively for use by cieTrade clients, Haber says the company plans to introduce a version of ciePhoto that can be used by any recycling companies that need to submit booking documents and photos.
For more information or a free demo, contact cieTrade Systems Inc. at firstname.lastname@example.com.


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9:00 am Workshop: "Warm-up Class!", presented by Chris James
This workshop will focus on maximizing efficiency in your practice routines. This informative workshop will help you incorporate new methods and ideas to keep daily practice interesting and fun!
11:00 am Workshop: "Basic Flute Repair" , Presented by Robert Johnson
Mr. Johnson is the President, Founder and Chief Technician of Flute Specialists, Inc. in Clawson, will draw upon three decades of experience in the flute sales and repair industry to discuss common issues of basic repair for every flutist.
Mr. Johnson studied flute performance at Academie Intenationale diet de Nice in Nice, France. The highlight of my performance career was performing a solo with an orchestra where he earned a degree in fine art with a focus in painting, sculpting and metalsmithing. He pursued technical training at the invitation of Muramatsu Flute engineers at the Muramatsu Flute factory and facilities in Tokorozawa and Tokyo, Japan.
Join Mr. Johnson in an exploration of flute repair basics that will benefit flutists and their students at all levels.
1:00 pm Workshop: "6 Weeks to Anything", presented by Sharon Sparrow
In this workshop, Ms. Sparrow reveals her tried and true techniques of preparation in her recently published book "6 Weeks to Finals" and applies it to your personal musical event! From Solo and Ensemble, to studio recitals to any upcoming audition, knowing how to prepare successfully is the key ingredient to a positive performance experience!
Ms. Sparrow is a much sought-after clinician and has taught master classes all over the United States and in Canada and in France. She holds Flute Instructor positions locally at both Wayne State and Oakland University. In 2016, Theodor Presser Company published and released her book "6 Weeks to Finals", a detailed guide to taking orchestral auditions. She is thrilled to be coaching audition candidates from all over the country to be successful.
A dedicated advocate of musical education, Ms. Sparrow strives to promote awareness and enjoyment of classical music in all her endeavors, especially with children. She has written and hosted shows for both the Cuttime Players and the Detroit Symphony, and regularly performs in local schools, hospitals and retirement centers as part of the DSO's Community Enrichment program.
Sharon Sparrow received her Bachelor of Music from the prestigious Juilliard School, and Master of Music at Mannes College of Music. Her three major teachers were Julius Baker, Thomas Nyfenger and Geoffrey Gilbert.


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Gentlemen, Ladies, It is with great pleasure that we announce a new haven for soldiers, explorers, adventurers, and others whom some call rogues: 'The Honourable Company of Gentle men and women of Albion, its islands and Protectorates' called 'The Company of Albion' for short. Our (vaguely steampunk) aim is to bring together all types of gamer of whatever race, sex, gender or creed who have the same ethos: that of fun, exploration and mature gaming. Mature gamers can be of any age but are identified as those without a need to show off constantly (though healthy competition is thoroughly approved of!), help their fellow comany man or woman, and generally enjoy the experience of searching out new things.... ... as well as occasionally blowing things up... A LOT! Initially this will be an XBOX ONE clan, but with the hope that we might some day spread our wings! Until then, meet you on the flipside. Tally Ho!
Posting in language:


text:
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Privacy Statement | Accessibility Statement | Equal Employment Opportunity is the Law | Code of Conduct | Corporate Social Responsibility | Human Trafficking Policy Statement | UK Modern Slavery Transparency Act Statement | Site Map Copyright


text:
Ranking the Mega Man Games
February 29, 2016 - Which of the Blue Bomber's adventures reigns supreme?
13 Examples of Timeless Video Game Graphics
November 12, 2015 - From Asteroids to Ni No Kuni, here are 13 games that have aged gracefully over the past 35 years.
Protoman Statue Coming from First 4 Figures
April 14, 2015 - Mega Man's cooler brother now available for pre-order.
Mega Man Anniversary Sale Starts Today on Nintendo eShop
December 17, 2014 - Save up to 50% on some of the Blue Bomber's classics on Wii U and 3DS.
Samuel Claiborn's 400 Favorite Games of All Time
February 13, 2014 - Have you ever tried to rank all the games you've ever played? It's pretty fun until you hit 400.
Colin Moriarty's Top 25 Games of All Time
February 7, 2014 - Today, IGN's Senior Editor Colin Moriarty kicks-off the eds sharing their individual lists of what they think the best games of all-time are.
TGS: Shopping For Old-School Games In Tokyo's Akihabara
September 21, 2013 - After traveling to the gaming capital of Japan, one IGN editor left with a fistful of old-school games, and a head full of nostalgic memories.
The Games IGN Would Gift
December 16, 2012 - Our editors share the game experiences they'd most like to gift to loved ones, and ask for your suggestions.
An E-Tank Full of Every Classic Mega Man Song
June 21, 2012 - No classic gaming series matches Mega Man in terms of the quality of its soundtrack. And that soundtrack will soon be on sale.
Mega Man 2 isn't the Best Mega Man Game
April 4, 2011 - Mega Man 2 this, Mega Man 2 that. I'm sick of hearing about Mega Man 2. That's because the game that came after it is much better.
The 10 Steps to Mega Man 10
February 16, 2010 - With only a few weeks left before its March release, we can't wait for the Blue Bomber's next adventure -- so we're easing the wait by walking through each one of his classic outings, in order. Join us for this huge trip through time.
RetroCity Podcast, Episode 25
March 3, 2009 - 1982 was one of the biggest years in videogames -- and it's also the one that lead right into the great crash. This is the year of the Vectrex and Atari 5200, the Colecovision and Commodore 64. Arcade were filled with weirdness like Joust, Q*Bert, and Pengo. We thrilled to "Starcade" and the small screen and "TRON" on the silver screen. This week's RetroCity tracks the highlights of 1982 and features a story about auditioning for "Starcade" by IGN Wireless contributor George Roush. The episode ends with a short talk about retrogaming with Colin Moriarty of IGN Guides.
RetroCity Episode 18 Script
December 2, 2008 - Every few RetroCity podcasts, I get an email from a listener wondering if the episode is entirely scripted or if I'm just talking extemporaneously about classic games for 20 minutes. The answer is usually a combination of the two. Some episodes where I have a specific argument to make, I script the majority of the podcast. Other episodes are done from outlines with a few key passages scripted and the rest of it completely extemporaneous. Episode 18 of the podcast was one of the scripted episodes because I had some points I wanted to make about how gamers define the whole idea of "retro gaming" and I solicited contributions from other writers, including IGN editors like Colin Moriarty and Jessica Chobot, as well as Travis Fahs, whose work appears on IGN Retro weekly. And so, I thought I'd post the script from the episode (sans the intro and outro, which really don't need scripting). There are differences between the script and the podcast, but for the most part, here's what I said during what will be RetroCity's first discussion about the definition of retro gaming.
RetroCity Podcast, Episode 18
November 25, 2008 - There is no one agreed upon definition for retro gaming. Some define retro gaming by the music or visual aesthetics of each previous generation. Others define retro strictly via time lines. Perhaps you have your own definition, which you create with the help of a handful of games that embody your personal idea of retro gaming. This week's RetroCity doesn't attempt to define retro gaming in absolutes, but it does discuss possible parameters. Plus, IGN editors weigh in with their opinions on what retro is and what games they use to define it.
Mega Man 3 Review
November 10, 2008 - It's a good time to be a fan of Mega Man. After the Virtual Console release of his original adventure, then the VC debut of its immediate sequel, then the WiiWare arrival of the all-new Mega Man 9 and its two waves of downloadable content, you'd think that the floodgates might close for a while -- that Capcom might hold back the rest of its classic Mega Man games for some later time, to give Wii gamers a chance to breathe. That thought's just been blown to bits, though, as the avalanche of 8-bit Mega Man action just doesn't want to relent -- as evidenced by today's addition of Mega Man 3 to the VC lineup. Hope you still have some Wii Points left, Mega Man fans. Because it's a good time to be one of you.
Top 10 Mega Man Musical Moments
October 31, 2008 - The wildly successful Mega Man 9 has become the coolest kid on the retro-gaming block, and, true to its pedigree, it has a great soundtrack; the original six Mega Man titles for the NES had some of the bossest 8-bit tunes in all of... well, 8-bitdom. The aural horsepower developer Capcom managed to extract from that little sucker year in and year out was one of the series' strongest suits. Kids and teens spent the late 80s and early 90s flocking to rental outlets not only to check out the eight Robot Masters of each new installment, but also the eight criminally catchy tracks that would haunt them to their very beds, schooldesks, and baseball diamonds.
Retro Remix: Top 10 Unreleased NES Hits
October 10, 2008 - It all began with speculation. Hoping and dreaming, wishing for the best. When Nintendo's retro gaming download service, the Virtual Console, was first announced -- well, it was anyone's guess what games would appear. And anyone became our own Mark Bozon, who kicked off a feature called Retro Remix in the months leading up to the Wii's launch date to feature wishlist games we'd love to see on the service, and to assess whether or not they were actually likely to show up.
RetroCity Podcast, Episode 9
July 22, 2008 - Episode 8 of RetroCity was a touch short, so I'm making up for it this week with a super-sized edition. Craig Harris, Ryan Geddes, and Colin Moriarty join me for a roundtable about gaming in 1984, the NES v. Master System (Craig brings up the 7800 like it was a contender), and we jam a bit on Mega Man 9 -- which Colin and I both loved at E3 last week. Can you handle a 50-minute classic gaming nerd-splosion?
E3 2008: Hands-on Mega Man 9
July 16, 2008 - Dr. Wily wants your cash. Robots are going wild all over the world, wreaking havoc and disrespecting public property, and the infamous Dr. Albert Wily has called a primetime press conference to claim that he's not responsible – but he'll happily step in to stop the madness, for a price. Just call his toll-free number and make your pledge today.
Top 10 Mega Man Robot Masters
July 1, 2008 - Recently, Capcom revealed the impending launch of Mega Man 9, the next proper installment of the original Mega Man series. Mega Man has enjoyed no shortage of adventures since the American release of Mega Man 8 in 1997 on the Saturn and PlayStation (although, many would count Mega Man & Bass on the GBA in 2003), but Mega Man 9 will pit the Blue Bomber against a brand new crew of robot masters just like the classic games. According to early reports, Mega Man will square off against such monsters as Galaxy Man and Concrete Man. We can hardly wait to get our 8-bit on with Mega Man 9.


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Here's a more frightening thought: four hundred years of Islamic slavery -- having your Christian children taken away and raised as Moslems to return and rule over you and being treated as a subhuman where you are not even allowed to use your real name but instead are forced to respond to names your rulers give you like "potato" and "donkey"; going through wars of independence that fail time and time again until finally the last one against the Islamic invaders is successful; rebuilding your country, only to have it devastated by two World Wars killing off more than half of your male population and driving more into exile and then getting sold off to communism by the Major Powers, against your will; finally pulling yourself up and out of communism after another fifty years; and then the "piece de resistance" -- ultimately getting sold back into Islamic slavery by your supposedly "Western Christian brothers".
That's precisely what the Serbs have gone through.
Thank you for putting that into perspective.


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|Find the best surf spots
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This break is the opposite side of Makarori Point. Park your car at Whales which is the northern most beach break at Wainui Beach.Rats will be visable from the car park jsut to the left of the whale grave.
DistanceTake a car
WalkInstant access (< 5min)
Easy to find?Easy to find
Public access?Public access
Special accessDon't know
Alternative name Punga Punga Point
Wave qualityRegional Classic
ExperienceExperienced surfers
FrequencySometimes break
DirectionRight and left
BottomSandy with rock
PowerFast, Powerful, Ledgey
Normal lengthShort (< 50m)
Good day lengthShort (< 50m)
Good swell directionSouth, SouthEast, East, NorthEast
Good wind directionNorthWest
Swell sizeStarts working at 1.0m-1.5m / 3ft-5ft and holds up to 3m+ / 10ft+
Best tide positionMid and high tide
Best tide movementRising and falling tides
Week crowdEmpty
Week-end crowdEmpty
- Rocks
Rats reef consistantly breaks but is outshone by its other side makarori point 90% of the time.It has many take of points and is best surfed on a NE swell with very litle wind when the take off zone is more defined. The wave is fast and breaks over a shallow reef. The paddle out is easy when you find it perfect.
Rats reef is always worth a look but is often forgotten with surfers heading for Makarori or Wainui Beach breaks often with good reason. But if you do encounter one of its perfect days you will not be dissapointed. It breaks more consistantly left but this depends largley on the swell direction as it is more exposed to swell than Makarori Point.You can look across to Maka Point and see others in crowded conditions as you surf uncrowded perfection just 100 meters away.
If you find it working just right it will be an intense ride and awesome experience.
Author: Anonymous Contributors (1) They surfed this spot ! (1)
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|Aucune session
|Aucun voyage
By anonymous , 24-06-2005
the original is Punga Punga - I've surfed this place on a number of occasions when its been clean and connected all the way to whales. You gotta think the guy who wrote this up knows what hes talking about because he says its not good that often...you gotta catch it on. As for the name I've heard it called , Rats and Punga Punga Point. As I understood it it was called the later because in the 50's there were 2 punga trees right on the end of the Wainui side of the point....there are photos around to prove it..that got demolished in a storm in the early 60's. Neil Walker may have given it his own name..but at the end of the day who cares what its called as long as you get it on. If you dont like it dont surf it would be the suggestion.
By anonymous , 11-06-2005
makanui - this place is a myth, ive surfed it and its no good.the REAL name is MAKANUI as named by neil walker. you best be getting yaself to the point for the tide gets too low
By anonymous , 14-03-2004
Catch it - I've had the opportunity to surf this wave and its certainly an experience. It was ledgey,heavy and intense but one of the best surfs I've ever had. I've seen guys more talented than myself surf it and absolutly rip it but also saw them pay a nasty price when they became to complacent about the take off. All in all a wave not to be missed if you catch it on.
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USF: Concern for players' safety led to softball forfeit
USF's athletic department issued a statement Sunday afternoon stating that Bulls softball coach Ken Eriksen's decision to take his players off the field and forfeit a game at DePaul was related to "concerns related to the safety and welfare of ... team members," adding that USF has contacted the Big East's league office to inform them of those concerns.
USF's statement said the Bulls will have no further comment until the Big East office has "reviewed and addressed the matter." A posting to the Twitter.com page for USF softball had indicated that the forfeit was not related to any calls made by officials in Sunday's game, which ended in the bottom of the second inning with DePaul, which was ahead 1-0, given a victory by forfeit.
Such a forfeit is certainly rare, especially on the final day of the regular season -- Eriksen's decision directly impacted his team's seeding in the conference tournament. Had USF won, it would have earned the third seed in the field, but with the loss, the Bulls have the No. 4 seed in the eight-team tournament and will face fifth-seeded Louisville on its home field in Thursday's first round.
The Bulls and Blue Demons split a doubleheader on Saturday, with USF handing DePaul just its second conference loss to end a 16-game winning streak. Notre Dame had already earned the No. 1 seed in the Big East tournament before USF's game, but a DePaul win, coupled by a Notre Dame loss, would have given the Blue Demons a share of the regular-season crown; Notre Dame won its game to clinch the crown outright.
USF's issues with the game have nothing to do with field conditions or the officiating in the game -- there had been a rain delay on the same field Saturday, and a cancellation (rather than a loss) would make USF the No. 3 seed, rather than the No. 4. It is clearly an issue between Eriksen and DePaul -- he and Blue Demons coach Eugene Lenti have been conference rivals for 15 years.
DePaul addressed the issue with a two-paragraph posting on its official site, saying nothing more than that game officials had determined that DePaul won by forfeit after USF left the field.


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PR: Love Is in the Air with the Release of "Be My Valentine, Charlie Brown"
BURBANK, CA (December 3, 2007) – Warner Home Video (WHV) will steal consumers' hearts on January 15, 2008 with the deluxe edition DVD release of Be My Valentine, Charlie Brown. The all-time favorite seasonal animated television special, will be available just in time for Valentine's Day in its dazzling, newly re-mastered format along with a delightful bonus featurette and two extra episodes. Be My Valentine, Charlie Brown, Deluxe Edition will retail for $19.98 SRP. Order due date has been set for December 11, 2007.
Having made its original television debut in 1975, Be My Valentine, Charlie Brown, which stars the lovable Peanuts clan, focuses on the gang's preparations for the upcoming Valentine's Day holiday. Everyone has high hopes of having their dreams of love and friendship fulfilled. Charlie Brown wants to get a Valentine from anyone and patiently waits by his mailbox. Linus is on a mission to find a perfect Valentine's gift for his favorite teacher, Miss Othmar. Lucy wants Schroeder to finally notice her. Will they be satisfied to their heart's content or are they headed for heartbreak?
"We know that generations of viewers grew up watching many of these wonderful Peanuts specials on television and that's why we made it our goal to package these programs in a unique and distinctive way, starting with Be My Valentine, Charlie Brown," said Amit Desai, WHV Vice President, Family, Animation and Sports Marketing. He added, "Consumers will enjoy this special no matter what age they are. It's the type of program that can bring the whole family together and leave viewers with a warm, happy feeling."
DVD Special Features Include:
* Unlucky in Love: An Unrequited Love Story – What could a ten-year-old possibly know about love? This endearing featurette examines the love lives of the Peanuts characters and it also looks at how creator Charles Schultz's own personal views on love and relationships influenced his work. From Charlie Brown's infatuation with "The Little Red Hair Girl", to Lucy's longing for the pianist Schroeder.
* You're in Love, Charlie Brown (bonus episode) — With the school year coming to a close, Charlie Brown tries to work up the courage to meet his school-girl crush, the little red-haired girl and enlists the help of his pals Linus and Peppermint Patty.
* It's Your First Kiss, Charlie Brown (bonus episode) — It's homecoming night and Charlie Brown is asked to escort the homecoming queen, who just so happens to be the elusive, little red-haired girl whom Charlie has been pining for all his life.
Since the 1950's Peanuts is one of the most beloved comic strips in the world. Originally written and illustrated by Charles M. Schulz, the strip ran from 1950 until Schulz's death in 2000. The comic focused on a lovable crew of characters including Charlie Brown, Lucy Van Pelt, Charlie's pet beagle, Snoopy, and his side-kick Woodstock, as well as several other characters, which were the focus of funny, poignant stories of childhood for every season. Peanuts' tremendous success in print led to the comic strip's transition to its animated form, which was brought to life by producers Lee Mendelson and Bill Melendez. The highly popular television specials entertained generations of children and adults alike with their funny and poignant explorations of seasonal holidays and rites of passage that continue to air on television to this day. At this time, the Peanuts franchise has over 900 licensees worldwide.
Peanuts is licensed and syndicated by United Media. United Media (UM) is a worldwide licensing and syndication company that focuses on building brand equity around a wide range of creative content. The company recently partnered with HarperCollins to build a licensing program around the publishing phenomenon Fancy Nancy. United Media licenses and/or syndicates other properties, including Precious Moments, Dirty Dancing, Televisa's El Chavo, Mary Engelbreit, Raggedy Ann & Andy, and Dilbert. United Media is an E. W. Scripps Company (NYSE: SSP). For more information, visit www.unitedmedialicensing.com.
With operations in 90 international territories Warner Home Video, a Warner Bros. Entertainment Company, commands the largest distribution infrastructure in the global video marketplace. Warner Home Video's film library is the largest of any studio, offering top quality new and vintage titles from the repertoires of Warner Bros. Pictures, Turner Entertainment, Castle Rock Entertainment, HBO Home Video and New Line Home Entertainment.


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Wednesday, September 20, 2017
Symptom I am having after Leep procedure
I had a leep procedure done at the end of July 2009. I had a moderate case of pre-cancerous cells. After the surgery i had a period within the next week, and i noticed an odor. Since then I have had two more periods and it is now the end of october which would be normal but my period are really light since then. Say i wipe after going pee in the morning and i see light pink and that is it for a couple days. Before the procedure I had a lot more bleeding because i had a baby 10 months ago and it my periods became heavier since then. But i am worried now that the procedure messed my periods up and i am afraid that the blood is staying inside of me and not flowing out becuase its not normal for me. I still have this odor since the procedure too. I`m not sure what to do. I am only 19 years old and im wondering if the scar tissue from the procedure has blocked my menstral cycle and if i need to see my gyno.
The healing of the cervix after a LEEP can be associated with vaginal discharge, but it should have cleared by 3-4 weeks. It wouldn't change the timing of the period, but whether or not the blood could leave the uterus. You should be evaluated to make sure you didn't have scarring of the cervix that would make it difficult for all the blood to leave the uterus every month. It typically would be associated with prolonged light bleeding every month too. You should see your gynecologist to evaluate the cervix and cervical opening.
Thomas A deHoop, MD
Formerly Associate Professor of Clinical Obstetrics and Gynecology
Director, Medical Student Education
No longer associated


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South African woman caught with drugs in stomach taken into custody - Tv9
Wed, Sep 02, 2015, 08:11 AM
A south African woman, Moosa, who was caught with 51 capsules of banned drugs in her stomach at Shamshabad International Airport, was shifted from Osmania hospital to Narcotics Control Bureau office. She was discharged from the hospital after she was diagnosed with high blood pressure. Police will perform narco analysis test on her to know who are the kingpins behind drug smuggling.