text:
Once more into the breach: Fred Topel's coming at you with reviews of all the hottest movies at Fantastic Fest 2011, so we're going to get out of the way and just let him do his thing.
A BOY AND HIS SAMURAI – I can see why this was the audience favorite of Fantastic Fest. It's totally cute crowd pleasing. A samurai winds up in the future, bonds with a boy and his mother and becomes a successful chef. I'm still more of a You're Next or Headhunters guy myself, and Japanese cinema doesn't touch me the way Hong Kong does. So I liked Samurai, didn't love it. It's not rocket science. The cute kid cries and the samurai teaches him to triumph over adversity. His culinary arts are impressive and his code shows that recovering from a mistake can be even more powerful than getting it right the first time. It also deals with gender roles in Japan and pays off the samurai swordplay. If that's your genre you'll love it.
JUAN OF THE DEAD – The Cuban zombie film brings a political and regional twist that really elevates the genre. Taking the perspective of a true hustler, Juan turns zombie killing into a business, and they work the title into the dialogue. There are great zombie hordes, with a combination of fast and slow zombies, and great kills with badass finishing moves. A zombie tango is genius, and their profanity is hilarious too. The expletives they come up with must be common locally but they're pretty elaborate by cinema dialogue standards. All the political problems Cuba has remain issues during the zombie outbreak, so that makes this one unique to a specific culture's voice.
KNUCKLE – This is a really good documentary, but I really hate what it's about. Families in Ireland settle their feuds with bare knuckle fights. These guys make soccer gangs look like reasonable democracy. The film captures some raw, brutal moments which is of course the ultimate triumph of documentary. To me, it's like bum fights, only the bums are gainfully employed and fighting for way dumber reasons. At least the bums are trying to get paid. The Hatfields and McCoys, or whatever the actual Irish families were called, hate entire extended families for isolated incidents provoked by individuals, and perpetuate them on principal rather than actually resolve them. Yes, they could kick my ass, and the best part must be imagining them at the premiere seeing 12 years of bad behavior illuminated.
SHORT FUSE – A good number of the horror shorts look like features. No Way Out, Incubator and The Unliving look polished and professionally shot. How to Rid Your Lover Of A Negative Emotion Caused By You has a creepy premise and an adorable couple. The comedies don't really work. They're not carefully produced enough to pull off the camp they're going for. Unliving is the most significant, a half hour piece about harnessing zombies for labor. Killing a zombie is actually illegal so that brings up some interesting issues for the genre.
YOU SAID WHAT? – This Norwegian comedy has an amazing premise. As a joke, a group of guys copies Takashi Miike's Audition to meet women. Only it works and they end up making the movie. Norway can do name dropping Hollywood spoofs too and Peter Stormare is their A-list cameo. That itself is funny. I know Stormare is an acclaimed legitimate actor but there's no way his name before a title gets you a theatrical release, even in Norway. Some of the jokes are about the incompetence of first time filmmakers, although other jokes are about how easily successful they are. The film kind of shows that if you just do it, even if it's for the wrong reasons, it ends up getting done. The film can go through all the standard rom-com motions, but still they made a friggin' movie. Of course the actress will find out and get mad, but they made a movie. There is already a tangible positive result from their misguided scheme.


text:
Beijing: How do you say satire in Mandarin?
Not known for its sense of humour, the Chinese Communist Party's official mouthpiece apparently fell for a parody by The Onion, the satirical newspaper and website, when it reported Tuesday in some online editions of People's Daily that Kim Jong Un, the young, chubby North Korean ruler, had been named the "Sexiest Man Alive for 2012."
Or did it?
The brief article, accompanied by a 55-photograph slide show, quoted from The Onion as evidence: "With his devastatingly handsome, round face, his boyish charm and his strong, sturdy frame, this Pyongyang-bred heartthrob is every woman's dream come true. Blessed with an air of power that masks an unmistakable cute, cuddly side, Kim made this newspaper's editorial board swoon with his impeccable fashion sense, chic short hairstyle and, of course, that famous smile."
The slide show revealed Kim in a variety of poses, like sitting atop a galloping white horse and greeting throngs of beaming North Korean soldiers.
The headline and slide show became a sensation on the Internet, and people wondered whether People's Daily had been duped by The Onion article, which appeared Nov. 14.
John Delury, a scholar of Chinese and Korean history at Yonsei University in Seoul, South Korea, said, "If it's sincere, then it says something about the gullibility of a certain People's Daily editor."
There were signs that someone at People's Daily might have created the slide show with a subversive wink. The same day, the English-language edition of People's Daily Online ran a 15-photograph slide show under the headline "'Sex Tape' Official at Work."
The tongue-in-cheek slide show referred to an official in Chongqing, Lei Zhengfu, who was humiliated last week when someone leaked a video online of Lei having sex with an 18-year-old mistress in 2007.
The People's Daily slide show showed Lei doing his job as an official. Another slide show this month showed women at the 18th Party Congress under the headline "Beautiful Scenery."
The original Onion article, a parody of People magazine's annual "Sexiest Man Alive" feature, listed previous winners as Bashar Assad, Bernard L. Madoff and Ted Kaczynski.
Will Tracy, its author, said in a telephone interview that he believed People's Daily and The Korea Times, which also picked up the story, did not realize the original was intended as a prank. He said he had thought the list of previous winners, filled with "renowned maniacs," was enough of a red flag.
Tracy added that The Onion had issued a formal statement.
"We are pleased that one of our many fine Communist subsidiaries, the People's Daily in China, has received accolades for its coverage of our Sexiest Man Alive announcement," the statement said. "The People's Daily has served as one of The Onion's Far East bureaus for quite some time, and I believe their reportage as of late has been uncommonly fine, as well as politically astute."
People's Daily could not be reached for comment Tuesday night.
The online version of People's Daily does not go through the same rigorous editing process as the print edition.
In 2002, Beijing Evening News ran an Onion article that said the U.S. Congress was considering leaving Washington to look for a new capitol building. In September, the Fars News Agency of Iran, which is semi-official, published an Onion article that said a Gallup poll had found that more rural, white Americans would vote for President Mahmoud Ahmadinejad of Iran than President Barack Obama.
When Tracy was asked Tuesday whether he had any concerns that the misinterpretation of these articles could provoke international incidents, he said, "The Onion fully intends to provoke international incidents."
(Christine Haughney contributed reporting from New York)
© 2012, The New York Times News Service

subset: commoncrawl


text:
Mount Olympus Games
Based in Salt Lake City, Utah
Release date:
Regular Price:
Together: Amna & Saif is a couch co-op adventure puzzle game focused on interdependence. Our goal is for people to think about each other and have a better relationship for having played our game. Together is designed from the ground up to be co-op only. This allows us to explore and do things that would otherwise be impossible. Every aspect of the game is designed to foster interaction, communication, and empathy. To accomplish that we decided to not have violence, special abilities or differences in the two characters in the game. Making players the same removes barriers to empathy. And feeling powerful inhibits empathy. We will be running a kickstarter in late May for Together.
Development on Together started in March of 2013. Evan our Artist was brought on around September of the same year. Filippo was brought on to do music in April of 2014.
- Together exemplifies the benefits that gaming can have on a relationship. It goes beyond having a conversation or doing something together. Interdependence is a key quality in a rewarding and successful relationship and Together allows you to experience and practice it in a tangible way.
- Play with anyone. Optional challenges keep the game interesting for more advanced players while keeping the core game approachable.
- Accessibility: we are doing everything we can to make Together playable by anyone
Trailer YouTube
Logo & Icon
Selected Articles
- "there was no shortage of high-fives between my partner and I during our preview of the game...If my early experience with the game is any indication of what its future will be like, I have high hopes that Together will succeed in every way."
- Antony Stevens, Indie Game Magazine
Request Press Copy
Please fill in your e-mail address below and we'll get back to you as soon as a press copy is available for you.
Alternatively, you can always request a press copy by sending us a quick email.
Additional Links
About Mount Olympus Games
We care about making games that benefit society. We want players lives to be better for having played our games. Together: Amna & Saif exemplifies the benefits that gaming can have on a relationship. It goes beyond having a conversation or doing something together. Interdependence is a key quality in a rewarding and successful relationship and Together allows you to experience and practice it in a tangible way.
More information
More information on Mount Olympus Games, our logo & relevant media are available here.
Together: Amna & Saif Credits
Lyle Cox
Programmer, Designer, Owner
Evan Munro
Art Director, Freelancer on Together
Becky Pennock
Animation, Freelancer on Together
Filippo Beck Peccoz
Music, Freelancer on Together
presskit() by Rami Ismail (Vlambeer) - also thanks to these fine folks


text:
Santa Cruz ready to 'pay back' Blackburn
Roque Santa Cruz committed his future to Blackburn because he felt compelled to 'pay back' the club for the faith they showed in him.
The Paraguay international had been the subject of firm interest from other clubs this summer after an impressive debut season in the Barclays Premier League, with Manchester City lodging an unsuccessful bid to take him to Eastlands.
But Santa Cruz last week signed a new four-year deal to demonstrate his commitment to Rovers and revealed he felt the need to demonstrate his loyalty to the club after they signed him from Bayern Munich a year ago despite a history of serious knee injuries.
The 27-year-old told the Daily Mail: 'People sometimes say when you are in a good position, you need to go to a better team.
'But I have something to pay back to the club. When the club have done something good for you, you have to be aware of it and do something good for the club.
'They offered me the chance to become a better player. That's why I came here in the first place, and that's also the reason why I signed a new deal.'
Use a Facebook account to add a comment, subject to Facebook's Terms of Service and Privacy Policy. Your Facebook name, photo & other personal information you make public on Facebook will appear with your comment, and may be used on ESPN's media platforms. Learn more.


text:
(Lithium battery story updated with stock price update on Toronto Stock Exchange-traded lithium battery stock Electrovaya.)
NEW YORK ( TheStreet) -- The global push for fuel economy has prompted a growing gravitational pull towards electric vehicles, prompting the investment community to increasingly consider the makers of rechargeable lithium batteries for these vehicles as an investment opportunity.
U.S. stock exchange-traded companies in the lithium battery business have been working round the clock to ready themselves for the expected expansion of the electric car market. In Canada, lithium battery pure play Electrovaya has surged about 173.5% year to date on the Toronto Stock Exchange. The company recently brought on former Chrysler president of global electric motorcars, Bruce Coventry, as vice president of operations, and has become the supplier of a Tier 1 automotive OEM (original equipment manufacturer).


text:
October 31, 2013
Marquette Law School Poll indicates tight governor's race
Although the election for governor remains more than a year away, the latest Marquette University Law School Poll released Tuesday revealed that Republican Gov. Scott Walker had 47 percent and Democratic candidate Mary Burke had 45 percent of registered voters' support. The poll also looked at Walker's approval rating, same-sex marriage, voucher schools and the Affordable Care Act, among other topics.
Story appeared in the Milwaukee Journal Sentinel, Oct. 30, 2013
Associated Press story appeared on GreenBayPressGazette.com, NBC15.com and WiscNews.com, Oct. 29-30, 2013
Similar and related stories appeared on JSOnline.com, WPR.org, Madison.com, WisPolitics.com, StarTribune.com, WUWM.com, HTRNews.com and dozens of other websites, Oct. 29-30, 2013
Similar and related stories aired on WTMJ-AM (AM 620), WDJT-TV (CBS 58), WISN-TV (ABC 12), WHAD-FM (FM 90.7) WAOW-TV (ABC 9) and numerous other outlets statewide, Oct. 29, 2013
Marquette receives grant for high school computer science curriculum
The National Science Foundation granted $844,000 to Marquette University to help introduce more computer science courses to ninth- and 10th-grade students in Wisconsin high schools so that students can learn about careers related to computer science before graduation.
Story appeared on BizTimes.com, Oct. 24, 2013
Christopher (Shaun) Longstreet, director of the Center for Teaching and Learning, co-authored an article discussing the process of searching for alternative careers, full-time non-teaching and non-research positions within higher education.
Article appeared on InsideHigherEd.com, Oct. 30, 2013
Youth on a quest to reclaim a Safe Milwaukee
The Marquette University Volunteer Corps joined the arts against violence workshop with Safe & Sound, Inc., and the Violence Prevention Initiative of the Medical College of Wisconsin to assist young people with projects focusing on bullying prevention, violence, gang activity, substance abuse, or to share their vision of a safer, healthier community.
Story appeared on MilwaukeeNNS.org, Oct. 29, 2013
Howard Fuller, director of the Institute for the Transformation of Learning, commented on the progress of racial and economic equality in Wisconsin, saying there still remains a gap between the wealthy and the poor.
Story appeared on WPR.org, Oct. 29, 2013
George Koonce, director of development, discussed his concern for concussions and brain injuries in football, the progress he's seen over the years and the improvements he hopes to see in the future.
Story aired on WISN-TV (ABC 12), Oct. 28, 2013
Larry Williams, vice president and director of intercollegiate athletics, has been named a member of the Cultural and Entertainment Capital Needs Task Force. This task force aims to focus on identifying funding options to preserve and enhance key facilities in the four-county metropolitan area, including the BMO Harris Bradley Center.
Story appeared in the Milwaukee Journal Sentinel, Oct. 26, 2013
Similar story appeared on BizJournals.com, Oct. 25, 2013
Dan Zitomer, professor of civil, construction and environmental engineering, and director of the Water Quality Center, will be a partner in a new renewable energy project called the Forest County Potawatomi. Located in the Menomonee River Valley, the project aims to convert food wastes into renewable energy that will be sold to We Energies.
Story appeared in the Milwaukee Journal Sentinel, Oct. 27, 2013
Marquette hosts events to improve understanding of Islam
In collaboration with the Milwaukee Public Library, Marquette University will host events to help raise understanding of Islam in the United States and to dispel the myths that Islam is a foreign religion.
Story appeared in the Milwaukee Journal Sentinel, Oct. 26, 2013
Amanda Keeler, assistant professor of digital media, commented on the recent trend of Hollywood movies featuring and catering to older audiences, particularly baby boomer men.
Story appeared in the Milwaukee Journal Sentinel, Oct. 31, 2013
Past issues of In The News are available online.
Connect with Marquette onTwitter, Facebook, YouTube and Flickr.
Subscribe to In the News
Past issues of In The News are available online.
Subscribe to In the News


text:
Research Topics
Genomes and Genes
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications201 found, 100 shown here
- Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney diseaseSophie Liabeuf
INSERM ERI 12 EA 4292 and the Clinical Research Centre Division of Clinical Pharmacology, Amiens University Hospital, Amiens, France
Nephrol Dial Transplant 25:1183-91. 2010....
- Free p-cresol is associated with cardiovascular disease in hemodialysis patientsB K I Meijers
Division of Nephrology, Department of Medicine, University Hospital Leuven, Leuven, Belgium
Kidney Int 73:1174-80. 2008..Our study shows that free p-cresol is a novel cardiovascular risk factor in non-diabetic hemodialysis patients...
- Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patientsB Bammens
Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
Kidney Int 69:1081-7. 2006..These findings may encourage nephrologists to widen their field of interest beyond the scope of small water-soluble uremic solutes and middle molecules...
- p-Cresol and cardiovascular risk in mild-to-moderate kidney diseaseBjorn K I Meijers
Department of Medicine, Division of Nephrology and Laboratory for Gastro Intestinal Research and Leuven Food Science and Nutrition Research Centre LFoRCe, University Hospital Leuven, Leuven, Belgium
Clin J Am Soc Nephrol 5:1182-9. 2010..It is not known if p-cresol is associated with cardiovascular disease in patients with chronic kidney disease not yet on dialysis...
- New insights into uremic toxicityAmanda C Raff
Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
Curr Opin Nephrol Hypertens 17:560-5. 2008..New insights into the accumulation of uremic toxins and the loss of function of hormones and enzymes provide important information on the etiology of uremia...
- The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repairLaetitia Dou
INSERM EMI0019, UFR de Pharmacie, Universite de la Mediterranee, Marseille, France
Kidney Int 65:442-51. 2004..In addition, we tested the effect of uremic solutes that altered proliferation on endothelial wound repair...
- Erg K+ channels modulate contractile activity in the bovine epididymal ductMarco Mewe
Institute of Vegetative Physiology and Pathophysiology, University Medical Center, Hamburg Eppendorf, Hamburg, Germany
Am J Physiol Regul Integr Comp Physiol 294:R895-904. 2008..In summary, these data provide strong evidence for a physiological role of erg1 channels in regulating epididymal motility patterns...
- A uremic solute, P-cresol, inhibits the proliferation of endothelial progenitor cells via the p38 pathwayYuan Ying
Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Circ J 75:2252-9. 2011..Endothelial dysfunction is a consistent finding in uremic patients. Whether the uremic solutes, p-cresol and indoxyl sulfate, affect the cellular function of endothelial progenitor cells (EPCs) was tested...
- P-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical productionEva Schepers
Renal Division, Department of Internal Medicine, University Hospital, De Pintelaan 185, 9000 Gent, Belgium
Nephrol Dial Transplant 22:592-6. 2007..Recently, however, it has been demonstrated that p-cresol in the human body is conjugated, with p-cresylsulphate as the main metabolite...
- p-Cresyl sulfate and indoxyl sulfate in hemodialysis patientsBjorn K I Meijers
Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
Clin J Am Soc Nephrol 4:1932-8. 2009..They share important features such as the albumin-binding site, low dialytic clearance, and both originate from protein fermentation. Whether serum concentrations are related is, however, not known...
- The uremic retention solute p-cresyl sulfate and markers of endothelial damageBjorn K I Meijers
Department of Medicine, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
Am J Kidney Dis 54:891-901. 2009..In hemodialysis patients, the protein-bound uremic retention solute p-cresol is independently associated with cardiovascular disease. The underlying mechanisms have not been elucidated...
- Removal of P-cresol sulfate by hemodialysisAndres W Martinez
Department of Medicine, Veterans Association, Palo Alto, California, USA
J Am Soc Nephrol 16:3430-6. 2005..PCS is poorly removed by hemodialysis because its clearance is limited by protein binding and the ratio of its volume of distribution to its clearance is high...
- Protein-bound uraemic toxin removal in haemodialysis and post-dilution haemodiafiltrationDetlef H Krieter
Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
Nephrol Dial Transplant 25:212-8. 2010..In the present study, the impact of the albumin permeability of recently introduced advanced high-flux dialysis membranes on the removal of such substances was tested in haemodialysis and online post-dilution haemodiafiltration...
- Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)Rie Schultz Hansen
Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
Mol Pharmacol 69:266-77. 2006..In conclusion, HERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents an interesting new antiarrhythmic approach...
- p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney diseaseI Wen Wu
Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan
Nephrol Dial Transplant 26:938-47. 2011..However, only a few prospective studies have evaluated possible associations between these two retained solutes and renal disease progression in chronic kidney disease (CKD) patients...
- Persistence with overactive bladder pharmacotherapy in a Medicaid populationFadia T Shaya
Center on Drugs and Public Policy, University of Maryland School of Pharmacy, Baltimore, USA
Am J Manag Care 11:S121-9. 2005....
- Superior efficacy of fesoterodine over tolterodine extended release with rapid onset: a prospective, head-to-head, placebo-controlled trialSteven A Kaplan
Department of Urology, Weill Cornell Medical College, Cornell University, New York, NY, USA
BJU Int 107:1432-40. 2011..To show the superior efficacy of fesoterodine over tolterodine extended release (ER) in a placebo-controlled overactive bladder (OAB) trial with predefined treatment comparisons for both diary measures and patient-reported outcomes...
- Efficacy and tolerability of mirabegron, a β(3)-adrenoceptor agonist, in patients with overactive bladder: results from a randomised European-Australian phase 3 trialVik Khullar
St Mary s Hospital, Imperial College, London, UK
Eur Urol 63:283-95. 2013..Mirabegron, a β(3)-adrenoceptor agonist, has been developed for the treatment of overactive bladder (OAB)...
- Serum protein-bound uraemic toxins and clinical outcomes in haemodialysis patientsCheng Jui Lin
Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
Nephrol Dial Transplant 25:3693-700. 2010..We investigated the effect of serum p-cresol, indoxyl sulphate and other variables on clinical outcomes in HD patients during a 20-month follow-up...
- Persistence, adherence, and switch rates among extended-release and immediate-release overactive bladder medications in a regional managed care planAnna O D'Souza
Xcenda, LLC, Cincinnati, OH 45255, USA anna dsouza xcenda com
J Manag Care Pharm 14:291-301. 2008..No study has compared persistence and adherence to therapy for both the ER and IR versions of tolterodine and oxybutynin...
- Mechanism of action of a novel human ether-a-go-go-related gene channel activatorOscar Casis
Nora Eccles Harrison Cardiovascular Research and Training Institute and Department of Physiology, University of Utah, Salt Lake City, 84112, USA
Mol Pharmacol 69:658-65. 2006..We conclude that NS1643 is a partial agonist of hERG channels and that the mechanism of activation is reduced channel inactivation...
- Comparison of fesoterodine and tolterodine extended release for the treatment of overactive bladder: a head-to-head placebo-controlled trialSender Herschorn
Sunnybrook Health Sciences Centre, Division of Urology, University of Toronto, Toronto, Ontario, Canada
BJU Int 105:58-66. 2010..To compare the efficacy and tolerability of fesoterodine 8 mg with tolterodine extended-release (ER) 4 mg and placebo in a randomized clinical trial of patients with an overactive bladder (OAB)...
- p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresolT Selmer
Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat, Marburg, Germany
Eur J Biochem 268:1363-72. 2001..Based on the identification of p-hydroxyphenylacetate decarboxylase as a novel glycyl radical enzyme and the substrate specificity of the enzyme, a catalytic mechanism involving ketyl radicals as intermediates is proposed...
- P-cresol, a uremic retention solute, alters the endothelial barrier function in vitroClaire Cerini
INSERM EMI0019, Faculte de Pharmacie, Université e la Méditerranée, 27 bld Jean Moulin, 13385 Marseille, Cedex 5, France
Thromb Haemost 92:140-50. 2004..In conclusion, these results show that p-cresol causes a severe dysfunction of endothelial barrier function in vitro and suggest this uremic retention solute may participate in the endothelium dysfunction observed in CRF patients...
- Destruction of cresols by Fenton oxidation processV Kavitha
Centre for Environmental Studies, Anna University, Chennai 600 025, India
Water Res 39:3062-72. 2005The present study was used to probe the treatment of simulated wastewater containing cresols by Fenton process...
- Dose and aging effect on patients reported treatment benefit switching from the first overactive bladder therapy with tolterodine ER to fesoterodine: post-hoc analysis from an observational and retrospective studyDavid Castro-Diaz
Department of Urology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
BMC Urol 12:19. 2012..This study aimed to assess the effect of aging and dose escalation on patient-reported treatment benefit, after changing their first Overactive Bladder (OAB) therapy with tolterodine-ER to fesoterodine in daily clinical practice...
- Enhanced repolarization capacity: new potential antiarrhythmic strategy based on HERG channel activationG Szabo
Department of Physiology, University of Debrecen, Nagyerdei Krt 98 H 4012 Debrecen, Hungary
Curr Med Chem 18:3607-21. 2011..Although the multiple ion channel activity of NS1643 may carry proarrhythmic risk, the rationale of antiarrhythmic strategy based on I(Kr) activation is not questioned...
- Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channelsA P Larsen
The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen N, Denmark
Br J Pharmacol 161:614-28. 2010..1a isoform. In this study, the effects of two different K(v)11.1 activators, NS1643 and RPR260243, were characterized on K(v)11.1a and K(v)11.1b channels...
- Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643Morten Grunnet
Department of Drug Discovery Portfolio Management, Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
Mol Pharmacol 79:1-9. 2011....
- Final report on the safety assessment of sodium p-chloro-m-cresol, p-chloro-m-cresol, chlorothymol, mixed cresols, m-cresol, o-cresol, p-cresol, isopropyl cresols, thymol, o-cymen-5-ol, and carvacrolAlan Andersen
Cosmetic Ingredient Review, Washington, DC 20036, USA
Int J Toxicol 25:29-127. 2006Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol (PCMC), Mixed Cresols, m-Cresol, o-Cresol, p-Cresol, Isopropyl Cresols, Thymol, Chlorothymol, o-Cymen-5-ol, and Carvacrol are substituted phenols used as cosmetic biocides/preservatives and/or ..
- Biodegradation of p-cresol by Bacillus sp. strain PHN 1P N Tallur
Department of Biochemistry, Karnataka University, Dharwad, 580003, India
Curr Microbiol 53:529-33. 2006..Such a bacterial strain can be used for bioremediation of environments contaminated with phenolic compounds...
- Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643Serdar Durdagi
Institute for Biocomplexity and Informatics, Department of Biological Sciences, University of Calgary, Calgary, Canada
J Pharmacol Exp Ther 342:441-52. 2012..Model-guided mutagenesis led to the discovery of a range of novel interacting residues that modify NS1643-induced pharmacologic responses...
- Strong activation of ether-à-go-go-related gene 1 K+ channel isoforms by NS1643 in human embryonic kidney 293 and Chinese hamster ovary cellsAnna M Schuster
Institute of Cellular and Integrative Physiology, University Medical Center Hamburg Eppendorf UKE, Hamburg, Germany
Mol Pharmacol 80:930-42. 2011..laevis oocytes...
- Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD3Xulin Xu
Department of Physiology and Biophysics, Virginia Commonwealth University, 1101 E Marshall Street, Richmond, VA 23298, USA
Mol Pharmacol 73:1709-21. 2008..We suggest that PD may work as a "pore-modifier" of the hERG channel...
- Randomized, double-blind placebo- and tolterodine-controlled trial of the once-daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladderC R Chapple
Department of Urology, Royal Hallamshire Hospital, Sheffield, UK
BJU Int 93:303-10. 2004..e. urgency, incontinence, and frequency, with additional objectives being to assess the safety and tolerability of solifenacin and to compare the efficacy and safety of solifenacin with tolterodine 2 mg twice daily...
- P-cresol, a uremic toxin, decreases endothelial cell response to inflammatory cytokinesLaetitia Dou
INSERM EMI0019, Faculte de Pharmacie, Universite de la Mediterranee, and Service de Néphrologie, Hopital de la Conception, Marseille, France
Kidney Int 62:1999-2009. 2002..We asked whether p-cresol alters endothelial adhesion molecule expression and modifies endothelial/leukocyte adhesion...
- A small-molecule modulator interacts directly with deltaPhe508-CFTR to modify its ATPase activity and conformational stabilityLeigh Wellhauser
Research Institute, Hospital for Sick Children and Departments of Biochemistry and Physiology, University of Toronto, Canada
Mol Pharmacol 75:1430-8. 2009..These findings suggest that direct binding of this small molecule induces and/or stabilizes a structure that promotes the channel open state and may underlie its efficacy as a corrector of DeltaPhe508-CFTR...
- Efficacy, safety, and tolerability of extended-release once-daily tolterodine treatment for overactive bladder in older versus younger patientsNorman R Zinner
Doctors Urology Group, Torrance, California 90505, USA
J Am Geriatr Soc 50:799-807. 2002..To evaluate the efficacy, safety, and tolerability of a new, once-daily extended-release (ER) formulation of tolterodine in treating overactive bladder in older (> or =65) and younger (<65) patients...
- A sensitive HPLC method for the quantification of free and total p-cresol in patients with chronic renal failureR De Smet
Department of Internal Medicine, University Hospital Gent, Belgium
Clin Chim Acta 278:1-21. 1998..We conclude that the present method allows an accurate measurement of both total and free p-cresol, and that the measured concentrations in uremia are in the range which may cause biochemical alterations...
- Effect of toluene and cresols on Na+,K+-ATPase, and serotonin in rat brainDavid Calderón-Guzmán
Laboratorio de Neuroquimica, Instituto Nacional de Pediatría INP, Mexico
Regul Toxicol Pharmacol 41:1-5. 2005..Based in our results, it can be concluded that toluene and all cresols groups may increase lipid peroxidation and consequently induce changes in membrane fluidity.
- Centronuclear myopathy due to a de novo dominant mutation in the skeletal muscle ryanodine receptor (RYR1) geneHeinz Jungbluth
Dubowitz Neuromuscular Centre, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Neuromuscul Disord 17:338-45. 2007....
- Tolterodine: superior tolerability than and comparable efficacy to oxybutynin in individuals 50 years old or older with overactive bladder: a randomized controlled trialJ Malone-Lee
Department of Medicine, St Pancras Hospital, London, United Kingdom
J Urol 165:1452-6. 2001..The combination of these qualities makes tolterodine the preferred pharmacological therapy for the long-term treatment of this condition...
- Effects of tolterodine, trospium chloride, and oxybutynin on the central nervous systemA Todorova
Pro Science Private Research Clinic GmbH, Kurt-Schumacher-Str. 9, D-35440 Linden, Germany
J Clin Pharmacol 41:636-44. 2001..The minimal qEEG changes observed with tolterodine and trospium chloride reflect most probably a rebound message from the peripheral target organs. Prescription of oxybutynin thus implicates a higher risk of CNS side effects...
- Patient-reported outcomes in overactive bladder: importance for determining clinical effectiveness of treatmentLinda Brubaker
Department of Obstetrics, Loyola University Medical Center, Maywood, Illinois 60153, USA
Urology 68:3-8. 2006..We provide an overview of instruments used to assess symptoms, health-related quality of life, and treatment satisfaction in patients with OAB and discuss how PROs can be incorporated into clinical trial protocols...
- Assessing the role of p-cresol tolerance in Clostridium difficileLisa F Dawson
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
J Med Microbiol 57:745-9. 2008..difficile strains including 630, CF4 and CD196. Surprising, it was shown that Clostridium sordellii also has a high tolerance to p-cresol, suggesting an overlap in the tolerance pathways in these clostridial species...
- Factors associated with blood concentrations of indoxyl sulfate and p-cresol in patients undergoing peritoneal dialysisChien Te Lee
Division of Nephrology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan
Perit Dial Int 30:456-63. 2010..We conducted a cross-sectional study to analyze the factors that correlate with both total and free indoxyl sulfate and p-cresol...
- Effectiveness and tolerability of extended-release oxybutynin vs extended-release tolterodine in women with or without prior anticholinergic treatment for overactive bladderRodney U Anderson
Department of Urology, Stanford University School of Medicine, 300 Pasteur Drive, Suite 287, Stanford, CA 94305, USA
Int Urogynecol J Pelvic Floor Dysfunct 17:502-11. 2006..Discontinuation rates were comparably low across groups. The results demonstrate the appropriateness of initiating treatment for OAB with extended-release oxybutynin, particularly in women presenting with incontinence...
- A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoVJohn S Oxford
Retroscreen Virology Ltd, UK
Antivir Chem Chemother 16:129-34. 2005....
- Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndromeThomas G Diness
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
Cardiovasc Res 79:61-9. 2008..This study sought to evaluate the antiarrhythmic effect of a novel compound (NS1643) that activates the rapid delayed-rectifier K+ current, I(Kr), in two rabbit models of acquired LQTS...
- Clinical efficacy, safety, and tolerability of once-daily fesoterodine in subjects with overactive bladderChristopher Chapple
The Royal Hallamshire Hospital, Sheffield, UK
Eur Urol 52:1204-12. 2007..To determine the efficacy, tolerability, and safety of fesoterodine in subjects with overactive bladder (OAB)...
- Activation of ERG2 potassium channels by the diphenylurea NS1643Pernille Elmedyb
The Danish National Research Foundation Centre for Cardiac Arrhythmia, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
Neuropharmacology 53:283-94. 2007..It may be useful for revealing physiological functions of ERG channels in neuronal tissue as well as to elucidate the structure-function relationships of the ERG channels...
- Urinary incontinence at orgasm: relation to detrusor overactivity and treatment efficacyMaurizio Serati
Department of Obstetrics and Gynecology, University of Insubria, Del Ponte Hospital, Piazza Biroldi 1, Varese, Italy
Eur Urol 54:911-5. 2008..To understand the pathophysiological mechanism of incontinence during orgasm and to compare women affected by symptomatic detrusor overactivity (DO) with and without incontinence at orgasm in terms of efficacy of antimuscarinic treatment...
- Clinical efficacy and safety of tolterodine compared to oxybutynin and placebo in patients with overactive bladderH P Drutz
University of Toronto, Mount Sinai Hospital, Ontario, Canada
Int Urogynecol J Pelvic Floor Dysfunct 10:283-9. 1999..Tolterodine has equivalent efficacy to oxybutynin, but with less severe adverse effects. This will allow patients to receive more effective treatment for their condition, with better compliance...
- Validation of the urgency perception scaleLinda Cardozo
Urogynaecology, Kings College Hospital, London, UK
BJU Int 95:591-6. 2005..To ascertain the validity and responsiveness of the Urgency Perception Scale (UPS) as an indicator of perceived urinary urgency...
- Antimuscarinic agents exhibit local inhibitory effects on muscarinic receptors in bladder-afferent pathwaysYongTae Kim
Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Urology 65:238-42. 2005..To investigate the potential of antimuscarinic agents for sensory mechanisms in overactive bladder using intravesical instillation...
- Tolterodine: a safe and effective treatment for older patients with overactive bladderJ G Malone-Lee
Department of Medicine, Whittington Hospital, Royal Free and University College Medical School, London, Great Britain
J Am Geriatr Soc 49:700-5. 2001..CONCLUSION: Tolterodine (taken for 4 weeks) is safe and shows efficacy, particularly at a dosage of 2 mg bid, in the treatment of older patients with urinary symptoms attributable to overactive bladder...
- Does gender or age affect the efficacy and safety of tolterodine?Martin C Michel
Department of Medicine, University of Essen, Essen, Germany
J Urol 168:1027-31. 2002..We compared the importance of patient age and gender relative to the intensity of baseline symptoms of overactive bladder in the therapeutic response to the muscarinic receptor antagonist tolterodine...
- Randomized comparison of tolterodine with vaginal estrogen cream versus tolterodine alone for the treatment of postmenopausal women with overactive bladder syndromeLing Hong Tseng
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and University of Chang Gung School of Medicine, Tao Yuan, Taiwan
Neurourol Urodyn 28:47-51. 2009..To investigate whether vaginal estrogen cream combined with tolterodine is more effective than tolterodine alone in the treatment of postmenopausal women with overactive bladder (OAB)...
- A comparison of the efficacy and tolerability of solifenacin succinate and extended release tolterodine at treating overactive bladder syndrome: results of the STAR trialC R Chapple
Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Urology Research, South Yorkshire, UK
Eur Urol 48:464-70. 2005..To compare two new generation antimuscarinics at their recommended doses for treatment of overactive bladder syndrome (OAB)...
- Prospective randomized controlled trial of extended-release oxybutynin chloride and tolterodine tartrate in the treatment of overactive bladder: results of the OBJECT StudyR A Appell
Cleveland Clinic Foundation, Ohio, USA
Mayo Clin Proc 76:358-63. 2001..To compare the efficacy and tolerability of extended-release oxybutynin chloride and tolterodine tartrate at 12 weeks in participants with overactive bladder...
- Comparison of symptom severity and treatment response in patients with incontinent and continent overactive bladderMartin C Michel
Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
Eur Urol 48:110-5. 2005..Therefore, we have explored baseline symptoms and treatment responses to tolterodine in continent relative to incontinent OAB patients...
- Tolterodine once-daily: superior efficacy and tolerability in the treatment of the overactive bladderP Van Kerrebroeck
Department of Urology, University Hospital Maastricht, Maastricht, The Netherlands
Urology 57:414-21. 2001..Tolterodine ER demonstrated an improved efficacy for reducing urge incontinence episodes and a lower frequency of dry mouth compared with the existing IR twice-daily formulation...
- Relationships between improvements in symptoms and patient assessments of bladder condition, symptom bother and health-related quality of life in patients with overactive bladder treated with tolterodineK S Coyne
Center for Health Outcomes Research, United BioSource Corporation, Bethesda, MD 20814, USA
Int J Clin Pract 62:925-31. 2008..Relationships were evaluated between treatment-related improvements in overactive bladder (OAB) symptoms as recorded in bladder diaries and patient-reported symptom bother, bladder-related problems and health-related quality of life (HRQL)...
- Clinical efficacy and tolerability of extended-release tolterodine and immediate-release oxybutynin in Japanese and Korean patients with an overactive bladder: a randomized, placebo-controlled trialY Homma
Department of Urology, Tokyo University, Tokyo, Japan
BJU Int 92:741-7. 2003..To compare extended-release (ER) tolterodine and immediate-release (IR) oxybutynin with placebo in Japanese and Korean patients with an overactive bladder (OAB)...
- Tolterodine extended release improves patient-reported outcomes in overactive bladder: results from the IMPACT trialR Roberts
University of Wisconsin School of Medicine and Public Health, Madison, USA
Int J Clin Pract 60:752-8. 2006..Physicians reported that 68% of patients were 'much improved' or 'very much improved'. For symptom-defined conditions, patient-reported outcomes are a valuable means for determining responses to treatment...
- Nighttime dosing with tolterodine reduces overactive bladder-related nocturnal micturitions in patients with overactive bladder and nocturiaRaymond Rackley
Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
Urology 67:731-6; discussion 736. 2006..To evaluate the efficacy and tolerability of nighttime tolterodine dosing on urgency-related micturitions in patients with overactive bladder (OAB) and nocturia...
- Health-related quality of life of patients receiving extended-release tolterodine for overactive bladderCon J Kelleher
Guy s and St Thomas NHS Trust, London, United Kingdom
Am J Manag Care 8:S608-15. 2002..To compare the health-related quality of life (HRQoL) of overactive bladder (OAB) patients foilowing treatment with tolterodine extended-release (ER) 4 mg once daily versus placebo...
- Reduced perception of urgency in treatment of overactive bladder with extended-release tolterodineRobert Freeman
Urogynaecology Unit, Derriford Hospital, Plymouth, United Kingdom
Obstet Gynecol 102:605-11. 2003..To evaluate the effect of once-daily, extended-release tolterodine on urinary urgency in patients with overactive bladder...
- Prospective, randomized, double-blind study of the efficacy and tolerability of the extended-release formulations of oxybutynin and tolterodine for overactive bladder: results of the OPERA trialAnanias C Diokno
Department of Urology, William Beaumont Hospital, Royal Oak, Mich 48073, USA
Mayo Clin Proc 78:687-95. 2003..To compare the efficacy and tolerability of extended-release formulations of oxybutynin chloride and tolterodine tartrate in women with overactive bladder...
- Long-term health-related quality of life of patients receiving extended-release tolterodine for overactive bladderCon J Kelleher
Guy s and St Thomas NHS Trust, London, United Kingdom
Am J Manag Care 8:S616-30. 2002..To evaluate the long-term effects of tolterodine on the health-related quality of life (HRQoL) of patients diagnosed with overactive bladder with incontinence...
- Comparative efficacy and safety of transdermal oxybutynin and oral tolterodine versus placebo in previously treated patients with urge and mixed urinary incontinenceRoger R Dmochowski
Department of Urology, Vanderbilt University, Nashville, Tennessee, USA
Urology 62:237-42. 2003..To compare the efficacy and safety of an oxybutynin transdermal delivery system (OXY-TDS) and oral, long-acting tolterodine (TOL-LA) with placebo in previously treated patients with urge or mixed urinary incontinence...
- Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chloro-m-cresolJames D Fessenden
Department of Anesthesia Research, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 278:28727-35. 2003..Taken together, these results suggest that essential determinants required for activation of RyR1 by 4-CmC reside within a 173-amino acid region between residues 4007 and 4180...
- Tolterodine and memory: dry but forgetfulKyle B Womack
Department of Neurology, University of Florida College of Medicine, and the Neurology Service, Department of Veterans Affairs Medical Center, Gainesville, USA
Arch Neurol 60:771-3. 2003..Anticholinergic drugs are known to produce or enhance cognitive deficits. Tolterodine tartrate is marketed as a bladder-selective anticholinergic drug that is reported to be free of significant cognitive adverse effects...
- Tolterodine and tamsulosin for treatment of men with lower urinary tract symptoms and overactive bladder: a randomized controlled trialSteven A Kaplan
Department of Urology, Weill Cornell Medical College, New York, NY 10021, USA
JAMA 296:2319-28. 2006..Men with overactive bladder and other lower urinary tract symptoms may not respond to monotherapy with antimuscarinic agents or alpha-receptor antagonists...
- Transient memory impairment and hallucinations associated with tolterodine useJack W Tsao
N Engl J Med 349:2274-5. 2003
- Simplified bladder training augments the effectiveness of tolterodine in patients with an overactive bladderA Mattiasson
Department of Urology, University Hospital, Lund, Sweden
BJU Int 91:54-60. 2003..To compare the efficacy of tolterodine plus simplified bladder training (BT) with tolterodine alone in patients with an overactive bladder...
- Treatment of overactive bladder with once-daily extended-release tolterodine or oxybutynin: the antimuscarinic clinical effectiveness trial (ACET)David Sussman
Department of Surgery, University of Medicine and Dentistry of New Jersey, Stratford 08084, USA
Curr Med Res Opin 18:177-84. 2002..In conclusion, the greater efficacy and tolerability of tolterodine ER 4 mg suggests improved clinical effectiveness compared with oxybutynin ER 10 mg...
- Health-related quality of life of Japanese patients with overactive bladder treated with extended-release tolterodine or immediate-release oxybutynin: a randomized, placebo-controlled trialY Homma
Department of Urology, Tokyo University Hospital, 7 3 1 Hongo Bunkyo ku, 113 8655 Tokyo, Japan
World J Urol 22:251-6. 2004..Our findings demonstrate that Japanese OAB patients receiving tolterodine ER or oxybutynin experienced overall improvement in their quality of life...
- Treatment of urge-predominant mixed urinary incontinence with tolterodine extended release: a randomized, placebo-controlled trialVik Khullar
Department of Obstetrics and Gynaecology, Imperial College School of Medicine, London, United Kingdom
Urology 64:269-74; discussion 274-5. 2004..To examine the efficacy and tolerability of antimuscarinic therapy in women with urge-predominant mixed incontinence...
- The responsiveness of the Overactive Bladder Questionnaire (OAB-q)Karin S Coyne
MEDTAP International, Inc, Center for Health Outcomes Research, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
Qual Life Res 14:849-55. 2005..The purpose of this study was to examine the responsiveness of the Overactive Bladder questionnaire (OAB-q) during anti-muscarinic treatment...
- Treatment of phenol and cresols in upflow anaerobic sludge blanket (UASB) process: a reviewGali S Veeresh
Department of Civil Engineering, Indian Institute of Technology Roorkee, Roorkee 247667, India
Water Res 39:154-70. 2005..recognition of the UASB process, feasibility studies on the treatment of wastewater containing phenol and cresols (o-, m- and p- isomers) in UASB have been reviewed...
- Gas chromatographic-mass spectrometric analysis for measurement of p-cresol and its conjugated metabolites in uremic and normal serumHenriette de Loor
Department of Medicine, University Hospital Gasthuisberg K U Leuven, Leuven, Belgium
Clin Chem 51:1535-8. 2005
- Clinical efficacy of tolterodine with or without a simplified pelvic floor exercise regimenR J Millard
University of New South Wales, Sydney, Australia
Neurourol Urodyn 23:48-53. 2004....
- The clinical efficacy of tolterodine extended-release is maintained for 24 h in patients with overactive bladderRoger Dmochowski
Department of Urology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
BJU Int 100:107-10. 2007..To assess the 24-h efficacy of tolterodine extended-release (ER) in patients with overactive bladder (OAB) and urgency urinary incontinence (UUI)...
- Patient satisfaction with extended release tolterodine or oxybutynin in overactive bladderSusan C Bolge
Consumer Health Sciences, Princeton, NJ 08540, USA
Curr Med Res Opin 23:1903-12. 2007..To evaluate the effects of individual and condition characteristics on satisfaction with extended release tolterodine or oxybutynin in overactive bladder (OAB)...
- Pharmacological management of overactive bladder : a systematic and critical review of published economic evaluationsDenis Getsios
Caro Research Institute, Halifax, Nova Scotia, Canada
Pharmacoeconomics 23:995-1006. 2005..A more definitive pharmacoeconomic comparison of oxybutynin and tolterodine formulations, incorporating all available clinical data, and other treatment options would help direct treatment...
- Treatment of overactive bladder: a model comparing extended-release formulations of tolterodine and oxybutyninEleanor M Perfetto
The Weinberg Group Inc, Washington, DC, USA
Am J Manag Care 11:S150-7. 2005....
- Urodynamic effects of oxybutynin and tolterodine in conscious and anesthetized rats under different cystometrographic conditionsPatrizia Angelico
Pharmaceutical R and D Division, RECORDATI S p A, Via Civitali 1, 20148 Milan, Italy
BMC Pharmacol 5:14. 2005..The aim was to determine the experimental conditions required to reproduce the clinical pharmacological effects of antimuscarinic agents, as seen in humans, in particular their ability to increase bladder capacity...
- Retrospective evaluation of outcomes in patients with overactive bladder receiving tolterodine versus oxybutyninZhanna Jumadilova
Outcomes Research, Pfizer Inc, New York, NY 10017 5755, USA
Am J Health Syst Pharm 63:2357-64. 2006..The frequency, relative risk, resource utilization, and costs related to comorbidities associated with overactive bladder (OAB) were studied...
- Ocular side-effects of tolterodine and oxybutynin, a single-blind prospective randomized trialDexter Y L Leung
Br J Clin Pharmacol 60:668; author reply 669. 2005
- Efficacy and tolerability of tolterodine extended-release in men with overactive bladder and urgency urinary incontinenceClaus G Roehrborn
The University of Texas Southwestern Medical Center, Dallas, TX 75390 911, USA
BJU Int 97:1003-6. 2006..They found that it significantly reduced incontinent episodes and improved patient perception of treatment benefit in men with an overactive bladder..
- The emergence of new drugs for overactive bladderRebecca J McCrery
Division of Voiding Dysfunction and Female Urology, Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA
Expert Opin Emerg Drugs 11:125-36. 2006..Standard therapy is directed towards modifying the detrusor motor sensitivity and response via anticholinergic medication. Currently available medications are reviewed and alternative targets for treatment are presented...
- The latest in treatments for incontinence in womenJoyce Hinze
Nebr Nurse 39:22-6; quiz 27-8. 2006
- Intravesical instillation of human urine after oral administration of trospium, tolterodine and oxybutynin in a rat model of detrusor overactivityYongTae Kim
Department of Urology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA
BJU Int 97:400-3. 2006..To study the effects of antimuscarinics excreted into human urine on normal bladder in a rat model of detrusor overactivity...
- Comparison of the effectiveness and side-effects of tolterodine and oxybutynin in children with detrusor instabilityNizamettin Kilic
The Medical Faculty of Uludag University, Department of Paediatric Surgery, Bursa, Turkey
Int J Urol 13:105-8. 2006..The aim of this study is to assess the effectiveness and tolerability of tolterodine and oxybutynin in children with DI...
- Tolterodine extended release is efficacious in continent and incontinent subjects with overactive bladderEric S Rovner
Department of Urology, Medical University of South Carolina, 96 Jonathan Lucas St, CSB 644, Charleston, SC 29425, USA
Urology 72:488-93. 2008..To assess efficacy and tolerability of tolterodine extended release (ER) in continent and incontinent subjects with overactive bladder (OAB)...
- Comparison of efficacy of oxybutynin and tolterodine for prevention of catheter related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind studyA Agarwal
Department of Anaesthesia, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Br J Anaesth 96:377-80. 2006..This study was therefore undertaken to evaluate the efficacy of oxybutynin and tolterodine in preventing catheter related bladder discomfort...
- Safety and tolerability of extended-release oxybutynin once daily in urinary incontinence: combined results from two phase 4 controlled clinical trialsRobert B Armstrong
Ortho McNeil Neurologics, Inc, 1125 Trenton Harbourton Road, Titusville, NJ 08560 0200, USA
Int Urol Nephrol 39:1069-77. 2007..In total, 1.2, 1.0, and 1.6% of patients in the extended-release oxybutynin, extended-release tolterodine, and immediate-release tolterodine groups, respectively, discontinued study medication due to dry mouth...
- Contemporary treatment options for overactive bladderPaul H Taylor
Department of Family and Preventive Medicine, Emory University, Atlanta, Georgia, USA
- Bladder-health diaries: an assessment of 3-day vs 7-day entriesRoger R Dmochowski
Department of Urologic Surgery, Vanderbilt University Medical Center, 2201 West End Avenue, Nashville, TN 37235, USA
BJU Int 96:1049-54. 2005..To assess the reliability of symptom reports in 3-day vs 7-day bladder diaries used in clinical trials of patients with overactive bladder (OAB) and to compare those results and related issues with previous reports...
- Medical costs after initiation of drug treatment for overactive bladder: effects of selection bias on cost estimatesNicole M Nitz
Ingenix Company, Health Economics and Outcomes Group, Eden Prairie, Minnesota, USA
Am J Manag Care 11:S130-9. 2005....
Research Grants33
- DOPAMINE MONOOXYGENASE--MOLECULAR MECHANISMSJUDITH KLINMAN; Fiscal Year: 1999..abstraction from substrate; and (iv) distinction between species leading to enzyme turnover vs inactivation with cresols as mechanism based inhibitors...
- Urodynamic and Multiethnic Variability of Men Treated b*Steven Kaplan; Fiscal Year: 2005..Baseline urodynamic parameters which may predict improved outcome after MIST 3. The success of various types of MIST in treating BPH in African - American, Hispanic and Caucasian men. ..
- Removal of Protein-Bound Solutes by DialysisTimothy Meyer; Fiscal Year: 2007..The proposed ancillary study to the FHN will provide a unique opportunity to relate protein-bound solute levels to other chemical parameters and indices of well-being in a large group of hemodialysis patients. ..
- Maximize RAS Blockade in Diabetic NephropathyTimothy Meyer; Fiscal Year: 2003..But the number of such trials which can be performed is limited. Short term trials, such as those described in this proposal, are urgently required to help identify treatment regimens which merit further, longer term study. ..
- Mechanisms Progression in Renal InsufficiencyTimothy Meyer; Fiscal Year: 2006..These studies, like those of endocytosis, will employ knockout mice to assess the importance of potential mediators of injury which are not yet subject to pharmacologic manipulation. ..
- Donor Kidney Gene Expression and Delayed Graft FunctionTimothy Meyer; Fiscal Year: 2004..Ultimately, better understanding of these mechanisms should provide a basis for treatment to prevent cadaver kidney injury and improve graft function. ..
- Minimally Invasive Surgical Therapies Treatment Consort*Claus Roehrborn; Fiscal Year: 2005..The MIST Study Group will be a blueprint for a technology assessment group applicable to other areas of urology and other medical or surgical subspecialties. ..
- Pelvic Floor Changes Before and After BirthREBECCA GLENN ROGERS; Fiscal Year: 2010..This project will provide fundamental data to guide future decisions about labor interventions to prevent PF changes as well as data-based decisions regarding maternal request cesarean. ..
- ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDERAdil Bharucha; Fiscal Year: 2002..abstract_text> ..
- Iowa Pelvic Floor Disorders Clinical Trials NetworkKarl Kreder; Fiscal Year: 2005..abstract_text> ..
- Epidemiology and Mechanisms of Fecal IncontinenceAdil Bharucha; Fiscal Year: 2005..abstract_text> ..
- Patient-Oriented Models for Urinary Function in WomenLinda Brubaker; Fiscal Year: 2008..unreadable] b. To model urinary storage in health and disease [unreadable] c. To model urinary emptying in health and diseas [unreadable] [unreadable]..
- Interstitial Cystitis Clinical Research Network (ICCRN)Karl Kreder; Fiscal Year: 2007..abstract_text> ..
- NITRIC OXIDE REGULATORY SYSTEM IN THE PENISArthur Burnett; Fiscal Year: 2002....
- Chronic Prostatitis Collaborative Research NetworkMichel Pontari; Fiscal Year: 2007..Issues in developing a clinically relevant definition of urologic chronic pelvic pain syndromes are discussed. ..
- INTERSTITIAL CYSTITIS TREATMENT PROTOCOLSAlan Wein; Fiscal Year: 2003..C. patients across a large geographical area. This group's constant interaction creates a solid professional alignment that benefits patients from near and far. ..
- Treatment of Persistent Postprostatectomy IncontinencePatricia Goode; Fiscal Year: 2007..abstract_text> ..
- Serine-Protease Effects on the Epithelial Sodium ChannelRay Caldwell; Fiscal Year: 2006..Collectively, these components will be vital for him to emerge as an independent investigator [unreadable] [unreadable]..
- Molecular mechanisms of RyR activation by 4-CmCJAMES FESSENDEN; Fiscal Year: 2007..abstract_text> ..
- Proteomics of Cerebrospinal Fluid in Chronic Fatigue SyndromeJames Baraniuk; Fiscal Year: 2009..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
- Sensory Testing in Subjects with Interstitial CystitisMary FitzGerald; Fiscal Year: 2004..abstract_text> ..
- PHYSICIAN AND SCIENTIST TRAINING IN UROLOGICAL RESEARCHAlan Wein; Fiscal Year: 2007..Funding is sought for two years of support for three trainees annually. ..
- BOTULINUM TOXIN THERAPY FOR INTERSTITIAL CYSTITIS/CHRON*Mary FitzGerald; Fiscal Year: 2007..abstract_text> ..
- TRAINING IN UROLOGYAlan Wein; Fiscal Year: 2003..At each step the trainees will be advised by experienced investigators. It is expected that in return the clinician's will offer to the laboratory insight into the fundamental clinical problems facing the specialty of urology. ..
- Regulation of Bladder Smooth Muscle HyperplasiaPaul Austin; Fiscal Year: 2007..Work of this nature may decrease the morbidity and mortality that is caused by bladder outlet obstruction. ..
- Clinical Trial Development in Chronic Pelvic Pain Syndr*Daniel Shoskes; Fiscal Year: 2007..As an example of a potential clinical trial, a study of water induced thermotherapy is outlined. ..
- Function of the Urethra in Continent WomenKimberly Kenton; Fiscal Year: 2008..Normative ranges will be calculated for EMG, current perception thresholds, and urethral pressures for Caucasian and African American women. These data can then be used by other centers as reference data. [unreadable] [unreadable]..
- Chronic Prostatitis Collaborative Research NetworkRodney Anderson; Fiscal Year: 2007..abstract_text> ..
- The Role of NK-Kb signaling pathway--Intestitial CystitsRaymond Rackley; Fiscal Year: 2004....
- 2008 AUA/SBUR Summer Research ConferenceArthur Burnett; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Beaumont Interstitial Cystitis Clinical Research NetworkKenneth Peters; Fiscal Year: 2007..Adverse events and complications will be monitored. Ancillary studies as agreed upon by the ICCRN will be carried out in conjunction with the clinical trial. ..


text:
Get the most important digital marketing news each day.
Criteo's Overhauled Prediction Engine Now Factors Actual Conversions, Not Just Clicks
Personalized display advertising firm, Criteo, today announced a major update of its prediction engine, three years in the making.
The Criteo Engine has been retooled to automate impression bidding based on the likelihood that a user will both click on an ad and make a purchase. Up to now, bidding was based on click predictions.
Criteo says the engine's ability to close the prediction loop through to purchase has lifted sales volumes 38 percent while maintaining a stable cost-of-sale in A/B testing across billions of impressions and millions of users and clicks.
"We've solved a lot harder problem. The new engine predicts not just the click but whether the person is going to convert on the site," Jonathan Wolf, Criteo's Chief Product Officer, told me by phone. "In order to predict the one-in-ten-thousand impressions that would give the conversion, you need more data and a better algorithms … This new engine is a result of years of work. We dramatically improved the technology to do more volume at the same level of cost-of-sale and profitability targets."
The re-engineered Criteo Engine can process up to 15 million predictions per second and respond within 20 milliseconds. Criteo says it now stores more than 20 Terabytes of data daily, including actual purchase behavior.
The engine influences what products are shown in retargeted ads, says Wolf, and ads can be displayed across all networks including mobile web and in-app. Most current advertisers will be transitioned to the new engine by the end of the quarter.
We're listening.
Have something to say about this article? Share it with us on Facebook, Twitter or our LinkedIn Group.


text:
Immigration Law
Immigration Law Questions? Ask an Immigration Lawyer.
My husband and I filed for my i751 to remove the conditional status of my green card in April 2012. Unfortunately, we had to relocate to my home country (Singapore) in September 2012 as my husband lost his job. Meanwhile, we assumed that our i751 process will carry on smoothly. USCIS requested for more evidence and we submitted the documents as requested. In late April 2013 (one year after we filed), we received notice that we were scheduled for an interview on 9 May 2013. We could not make the interview date as we are living in Singapore. We promptly wrote in to the field office to request for a rescheduling. We did not get any reply. The next thing I knew, I had received another mail stating that my conditional residence status has been terminated and that deportation proceedings will be ordered. I'm now worried sick because: 1) Both my spouse and I are residing overseas. We are not able to fly back to the US on such short notice. What can we do? 2) It sounds really bad that my green card was terminated (and that I had not surrendered it voluntarily). Will this affect my chances of reapplying for a new green card when we are ready to return to the US in future?
Hello. Thank you for using our service. All I ask is that before you sign off, you rate me positively. If you are inclined to use the "poor service" or "bad service" options, please ask follow-up questions first and give me a chance. Sometimes the law doesn't have a good solution, but I will try hard to find it if it is available.
Well, I think you have two options.
1) File an I-290B which can be found at www.uscis.gov/forms and explain the situation and ask that the case be reopened so that you can go to a new interview.
2) Respond to the denial and explain that you are currently outside of the U.S. with no plans to come back any time soon and submit evidence that you are outside of the U.S. Then later you can apply for a new Lawful Permanent Residency through your spouse. What you have to avoid is them placing you in removal proceedings. If you do not end up in removal proceedings, then you should have no issue applying for a new Residency status in the future.
Please let me know if you have additional questions and please do not forget to rate my service to you (not the state of the law) as that is the only way that I can get credit for my assistance. Even after you rate the service, I can still answer additional questions for you without additional charge. If you do rate me positively, a bonus is always appreciated. If you would like to request me in the future, just go to http://www.justanswer.com/law/expert-guillermosenmartin/. Thank you!
Thank you for your advice. I am leaning towards option (2). Can you please offer more information on that?
1) Where should my letter be directed to? The field office handling my case?
2) If deportation proceedings are placed against me, what can/should I do since I am residing overseas? Can I get an attorney to represent me instead of being physically present in the US?


text:
Human Resources
Because one size doesn't fit all, please use the zoom feature of your browser to increase or decrease the text size.
Employee Assistance Program (EAP) - When life sends challenges your way, your Employee Assistance Program (EAP) is here to help. They provide free, confidential services for you and your family 24 hours a day, seven days a week. Their caring professional counselors want to help you overcome obstacles to live a healthy and productive life. Call them any time, day or night at 244-6090.
Be sure to check this page regularly for information on any upcoming Events!


text:
By Gus Osimitz updated on 08/10/2017
Many people still are reporting issues with their iphone battery draining even after upgrading to iOS 5.0.1. I happen to be one of these people :(. I called Apple Support. I would have a fully charged 4S battery at the beginning of the school day, and with very little light use the battery would be around 25-30% dead 7 hrs later, not at all close to the up to 200 hours Apple claims. Fortunately I have been able to make it through the rest of the day with a Zagg Sparq 2.0 and I really do love it. Apple recommends that I turn off all location services (or at least the ones I dont need), that I turn on automatic brightness. They also said that they recommend going into restrictions and disallowing ping. They said that there is something weird with ping that it can affect the battery life. I did all this so now I am just going to wait and see what happens!
You guys got any tips? be sure to leave a comment.


text:
Not too Shabby Chic
Clairrene's Treasures
Clairrene also builds custom cabinets, bookcases, hall trees, so get your measurements and give her a call!
Let Clairrene build a custom farm table for you. She can use solid pine, maple or poplar! Pine is a good price for couples on a budget! Any size, color, or leg.


text:
The scanner, which is being developed by scientists for Scotland Yard, could help police target offenders before they strike.
A spokesman for Scotland Yard stressed the work was still in the developmental stage and was part of a wide range of new technology being considered by the force.
The spokesman said the force would be using it "as soon as is practicable."
The scheme was initiated by Met Commissioner Sir John Stevens earlier this year as he announced a crack down on gun crime.
Figures show that shooting incidents across England and Wales rose by 35% from 17,589 in 2000-2001 to 22,314 last year.
Before the scanner takes to the streets the police may find they have to convince civil liberties groups concerned that the scanner - which is said to reveal intimate body details - is not an infringement of privacy.
Barry Hugill, of Liberty, said: "It is difficult to see a problem with technology that can actually locate guns and can help protect both police officers and the public from harm."


text:
Police find $2,000 worth of razors when helping disabled driver
Mon, 28 Jan 2013 17:32:33 GMT —
A Utica man, accused of stealing thousands of dollars worth of razors, was arrested when his car broke down.
State Police stopped to help a disabled driver on ST-12 in the Town of Remsen on Friday.
Police say 39-year-old Nathaniel Walker, of 125 Pleasant Street, had a suspended driver's license and hypodermic needles in the car. But that's not all. Police searched his car and say they found $2,000 worth of Gillette Fusion Razors which he had allegedly stolen from the Walmart on ST-12 in the Town of Lowville.
Walker is charged with grand larceny and possession of a hypodermic instrument.
Another man, 63-year-old John Makuch, of 100 Rutger Street, is charged with grand larceny.
Both men were arraigned in Lowville Town Court and sent to the Lewis County Jail on cash bail.


text:
working with ardour in a movie
first sorry about my bad english im from Brasil(Rio de Janeiro)i put linux in my machine and i start to work with ardour and unbuntu studio 1 month ago.I love it its so easy to edit sound,but how can i put sounds in a movie working with ardour?i try to search on net but i dont understand how to do that so if anybody give me a help i will aprecciate...again sorry about the bad english thanks a lot!
What you're looking for is Xjadeo, It is a video player that runs with JACK, I personally have it installed but haven't gotten into using it yet so I can't help you with the details.
Here is a great Ubuntu Audio repo where you can download Xjadeo:
arthur:thanks for the tip,i will use it. that movie(i was working)its ready.I record on ardour and after i sync with cinelerra...but i want to that at the same time...i will study the xjadeo....other question:do you know how can i put effects on a track on ardour?once again thanks!
i think you can´t connect cinelerra wirth ardour, cause cinelerra has no jack?!?. but you can syncronize xjadeo with ardour, so when the cutting is finished, you can do the sounddesign on it, but you can´t do both, soundediting and cutting at the same time...
when you have the cutting done render the movie to a smaller size, all that is described really good on the xjadeo homepage,...
putting effects: push right button when you´re on the channelstrip (under the input button, theres a blank black field, there!) and then choose your effects...
yes i can t connect with cinelerra...i put some notes on a paper with the markers and then i record on ardour .it was very complicated but you know im learning...it was a very short stop motion film...i gonna folow your tips...and try syncronize with xjadeo...and the effects to...thanks again


text:
Like a good horror movie, a good weight-loss regimen shocks the body out of its lethargy, which is why so many personal trainers chase their clients on treadmills while brandishing anacondas. Get in less terrified shape with today's Groupon: for $79, you get a weight-loss package at SlimXpress (a $379 value). Choose from the following locations: Everett, Seattle, or Tacoma.
The weight-loss package includes the following:
- Four lipotropic injections fortified with vitamin B12
- A preliminary medical consultation
- A body-composition measurement
- A custom SlimXpress workbook
- Two follow-up visits<p>
SlimXpress's silhouette-trimming lipotropic injections aim to activate the liver's fat incinerators and boost energy levels with vitamin B12. Packages begin with a medical consultation, during which a doctor or nurse listens to each client's weight-loss goals, illustrates the fundamentals of the using a workbook complied from two decades of research and a series of clips from The Incredible Shrinking Man, and evaluates each body's composition and rhetoric. Physiques receive their first in a series of four injections, the rest of which will be administered over consequent visits. Conducted by vitamin B12, a fugue of amino acids aims to jolt the metabolic rate awake, helping the liver expel fat stores so it has more room to horde its Bananarama LPs. The injections may help figures shed up to 14 pounds, with two follow-up visits tracking progress toward a more svelte shape.
At SlimXpress, scores of health professionals work to develop personalized weight-loss plans and bolster clients' personal fitness. Staff members analyze clients' health and physique goals, using results from an FDA-approved ultrasound system to draft a personalized plan. Through formulated injections, nutrition plans, and miniature campfires, waist whittlers are primed to reach ketosis, a bodily state resulting in natural metabolic fat burning. Each program and treatment employs knowledge grounded in science to ensure healthy weight loss.


text:
I believe in matching my nail polish with my mood, style and occasion. To me, it's so important! It adds that finishing touch to an outfit and really stands out and shows in the details. As you all know by now, you know I'm into red! I'm always sporting red lipstick so for this particular look I went for a fall look wearing all black with a few pops of red (my favorite)! In particular, I'm wearing my favorite Revlon Lipstick in Really Red and this Revlon Really Red nail polish! This nail polish is the perfect shade of red and I'm loving it for fall!
Like I said, I like to match my nails to my mood and occasion, however I'd sport a red nail Monday thru Friday and then again on Saturday. Wear red with a more professional and casual outfit for the week and then again Saturday night with that perfect little black dress for a pop of color that stands out. Red to me conveys sexy in so many ways, and this one is the perfect shade. Time to get ready for those fall holiday parties!
Revlon believes there is more than one way for women to be seen. Revlon's heritage as a color authority and its suite of innovative products inspires women around the world to express themselves through beauty each and every day.


text:
Interested in Language
and you will form a liking to TG very soon. Andrew is a cool guy. I like his student-friendly style of writing.
Regarding your question, IMO "was burned" is a quasi copula where "quasi" means the linking-verb retains its dynamic sense -- part of it.
There is a gradience running through from action verbs through to the class of copulas. The distinction between them is not clear-cut.
Dear Corum,
I don't know when I will have time to study TG, but, in the meantime, wouldn't you agree that Reed-Kellogg has the sizable advantage of not having to include any words in a diagram besides the words of the sentence that is being diagrammed?


text:
About 700 people from industry, academia, and politics gathered in St. Paul today Tuesday to learn about the latest trends in renewable energy.
It was the sixth annual "E-3" conference on energy, the economy and the environment.
"I think people are very excited about the many opportunities for renewable energy, alternative energy, whichever term you prefer, and the opportunities are there, and the urgency to move there quickly is significant," said Dick Hemmingsen, director of the University of Minnesota's Initiative for Renewable Energy and the Environment, which organized the conference.
Hemmingsen says businesses in Minnesota are very interested in renewable energy.
"One of the things I'm very pleased about is looking at attendees and how many are from businesses, large and small, who are here to learn more about these renewable energy opportunities, I do think there's very much of a strong sense of participation in this new bio-economy and the other renewable energy sources that we'll be developing," he said.
Speakers stressed the need for a national policy on climate change, to provide clear ground rules for industry, and to encourage development of new technologies.


text:
Skipper Scott Brown will discover on Monday if he requires surgery on an abductor problem, according to Celtic manager Neil Lennon.
The Hoops midfielder is waiting on results from a specialist and if an operation is necessary, it would likely mean him missing the second leg of the Champions League tie at Juventus on March 6 and Scotland's World Cup qualifying double-header against Wales and Serbia later next month.
Loading article content
Ahead of the visit of Dundee in the Clydesdale Bank Premier League on Sunday, Lennon said: "The specialist is coming back with his prognosis. He may need surgery but we won't know that until Monday, the specialist is on holiday at the minute.
"We are expecting the specialist to say he may need surgery so as soon as we get him a slot, if that is the case, then we will get it done.
"He is a very important player, the captain, but the squad is strong."
Lennon also revealed that Thomas Rogne has rejected the offer of a new deal. The Norwegian defender's contract is up at the end of the season.
"We have made him an offer and it has been refused," Lennon said. "We may go back to him with another offer but there are no guarantees on that.
"Obviously we don't want it to fester on, we would like to get a result one way or the other.
"Thomas is a good player, we would like to keep him around and there is a good chance of him playing on Sunday.
"He has had to be patient because Efe Ambrose, Charlie Mulgrew and Kelvin Wilson have done exceptionally well, but whenever Thomas has come in he has never let us down."
On midfielder Paddy McCourt, whose current deal also expires in the summer, Lennon said: "We will talk to Paddy and his representatives over the next couple of months."
Meanwhile, Brown and defender Mikael Lustig will be missing again for Celtic's Clydesdale Bank Premier League game against Dundee at Parkhead on Sunday.
Brown has seen a specialist about his abductor problem and will discover on Monday if he requires surgery while Lustig is out with a thigh injury.
Greece striker Georgios Samaras is back after recovering from a hamstring injury but defender Charlie Mulgrew is a doubt with a glute problem.
Provisional squad: Forster, Matthews, Wilson, Rogne, Mulgrew, Ambrose, Izaguirre, Forrest, Kayal, Ledley, Wanyama, Rogic, Stokes, Watt, Miku, Lassad, Zaluska, Samaras, McGeouch, Chalmers.


text:
House acts to cut funds for Health law
The House Republican drive to dismantle the new health care law piece by piece advanced Tuesday with a vote to disrupt the flow of federal dollars for health insurance exchanges, an integral part of the law's goal of expanding insurance coverage. The vote split mainly along party lines, 238-183. The bill is mainly a vehicle for Republicans to restate their case against the law enacted last year, since the Democratic-led Senate is likely to ignore it and the White House issued a veto threat in the event it passed.
U.S., Romania pick antimissile site
The United States and Romania announced an agreement on the location for basing U.S. antimissile interceptors in Romania as part of a program designed to link Washington and its NATO allies against an Iranian threat. Officials said the site selected for a key component of the missile-defense system was the Deveselu Air Base, near the city of Caracal in southern Romania. The deployment of the SM-3 missiles is expected by 2015, officials said. About 200 U.S. personnel are expected to help operate the system. Russia complained that the interceptors in Romania could undermine its nuclear deterrent, and said the step ignored commitments made by the United States that Russia would have a role in decisionmaking.
Second black box found in crash
French investigators said they recovered the cockpit voice recorder from the Air France jet that crashed in the mid Atlantic almost two years ago en route to Paris from Rio de Janeiro. After three failed searches and expenditures nearing $30 million, both of the jet's so-called black boxes are now in hand, giving investigators renewed hope of unraveling the mystery of what caused Flight 447 to go down on June 1, 2009, in a heavy thunderstorm. All 228 passengers and crew members were killed.
Officer who told on spy ring charged
The former Russian intelligence officer who helped U.S. authorities arrest the Russian spy ring last summer has been charged with high treason and desertion, reports said. The indictment for Alexander Poteyev, the man accused of tipping off American authorities about Anna Chapman and her fellow agents, has been passed to Moscow's main military court, news agencies said. His whereabouts are unclear.
Mexico: A gas explosion in a coal mine in northern Mexico killed three miners, injured one and left 11 others trapped deep underground. Officials said chances were slim anyone could have survived the massive blast.
Britain: Police said they arrested five men under antiterrorism laws near the Sellafield nuclear site in the north of England.
Times wires


text:
After watching football at all-sorts of different levels and in numerous nations over the last 20 years or so, you start to think you've seen pretty much everything that could happen on a football pitch in the professional game.
But that was taken to a new level for me on Wednesday evening, as I was given the opportunity to watch the Serbian Cup Final between FK Vojvodina and Partizan Belgrade.
With the European U17 Championship semi-finals taking place on Thursday morning, I spent the best part of Tuesday evening and Wednesday making sure I had done enough work to be able to make the trip down to the Marakana Stadium in Belgrade, home of Red Star.
The UEFA officials here in Novi Sad had generously put on a coach and sorted out tickets for delegates and staff at the competition to go and watch the match, so it was an opportunity I didn't really want to miss.
And what an incredible atmosphere awaited us! The kick-off had to be delayed by 30 minutes due to traffic in the Serbian capital which prevented many of the Vojvodina supporters from arriving on time, but that allowed the massed ranks of Partizan fans to really get things going.
Flags, flares, fireworks, banners and synchronised, loud chanting, they had it all. I really haven't heard anything like that at a football stadium in years.
Whilst outnumbered probably by three times, the Vojvodina supporters were exactly the same too, but it's what followed in the game that left me feeling a little sympathy for the fans of both clubs on the way home.
The first-half was a fairly scrappy affair, which Partizan no doubt edged and they took the lead through their rangy striker Prince Tagoe to hold the advantage at the break.
It was in the second half that all of the drama started to unfold, as Vojvodina tinkered with their formation and started to cause Partizan one or two problems before getting themselves deservedly level through big defender Daniel Mojsov.
They were on the front foot, but things then switched back in Partizan's favour remarkably quickly, as Tagoe's theatrical fall in the penalty box was rewarded with a penalty kick by the referee. Substitute Zvonimir Vukic stepped up to restore their lead.
After initially complaining strongly about the award of the spot-kick, Vojvodina hit back again and it appeared they equalised with ten minutes or so to go, when Mojsov rose unchallenged in the area to head a free-kick from the left past Vladimir Stojkovic. However, the referee immediately ruled that goal out, much to the disdain of everyone in the Vojvodina team and dugout.
Moments later, Nikola Lazetic appeared to be tripped in the Partizan box and when that appeal was turned down, pandemonium broke out as the Vojvodina team left the pitch in some sort of protest against the officials with just less than ten minutes to go. It was almost like something you would see on a park on a Sunday morning and myself, veteran youth scout Bernie Dickson and Youth Committee members Brian Adshead and David Edmunds just looked on in disbelief.
It was hard to tell whether the Partizan players were trying to stop them deserting the pitch, or just happy to let them get on with it and when things appeared to calm down, it looked as though we were going to finish the game as the majority of the team returned sheepishly to the field.
However, after a few more minutes of debate, they then headed en masse to their band of supporters to start orchestrating chants and applause. With players now apparently throwing shirts into the crowd, it was quite apparent the game wasn't going to get going again anytime soon.
So when the stadium scoreboard clock showed 90 minutes, the Partizan players suddenly darted off to celebrate in front of their fans. They had won the Cup.
We quickly departed to beat the traffic and get back to Novi Sad at a reasonable hour and everyone else on the coach was as equally stunned as us, including Serbs, Danes, Germans and Italians.
It's certainly a game I won't forget in a hurry, with a remarkable atmosphere but what took place on the pitch was quite unbelievable and in the end, it's the fans who you have to feel sympathy for. Although, the Partizan support certainly didn't let the manner of how the game ended stop their celebrations, that's for sure!
For now though, it's onto this morning's European U17 Championship semi-final, which is live on Eurosport at 10.30am BST. I'm fairly sure this game won't end in the same manner!


text:
Indian woman:Face effects >Costumes
Interesting photo face template "Indian woman" provides you with a opportunity to dress a garb and look at yourself from a distance.
From disk
From web
|Sorry, but image you have uploaded is too large and caused system to work slowly. Please upload image less than 10Mb.


text:
I am making cupcakes for a housewarming party. One of the toppers I want to make out of fondant is a welcome mat. However, the only lettering I have and can find is large. I have attached a picture I found that is a good example of the size. Any ideas suggestions? I have been all over the internet. The lettering size I need is like on the topper that has welcome and Home Sweet Home. Thank you!
Hope you find what will work for you. There are also small alphabet rubber stamp sets that can be impressed into fondant.
Thank you both so much. I will have to look at Michael's for those. Thanks again.
Thank you Pam! I think that will work great!
You are welcome! They have two, one with white letters which is just a noraml type and one with orange letters which is more of a script. Good luck!!
Hi Pam,
Can you tell me what that is called? I searched Michael's twice and asked for help, no luck. Ended up buying some stamps, just not sure if they will work.
I have a Joann's by my work and Hobby Lobby isn't too far but I can't even find online on their sites.
Oh no! Did you look in the section where the clay is? That is where I bought mine.
First, I didn't realize both pics you put are the same thing. (although you did explain... sorry) You know I don't think I ever saw clay anywhere lol. I went up and down every aisle and nook. I am going tomorrow to Joann's and will make sure I look in the clay area and know that I know what it is called. Thanks!
Yeah! I found it! I got the white. Thank you again!


text: ×Close Product Image 1 of 1 The Genie Scheme See image The Genie Scheme By Kimberly K. Jones For Ages: 8 - 12 When Janna buys a warm winter hat for a bag lady, she expects nothing in return. Imagine her surprise when the bag lady turns out to be a genie! Now Janna is the genie's master, and she couldn't be happier, especially when she finds out that the "three wishes" rule is strictly for fairy tales. It turns out wishes are unlimited, and Janna can have whatever she wants. There is a catch though: Genies can't make something out of nothing, so everything Janna gets comes from somebody else. Bummer. Plus there's a limited amount of genie wattage, and Janna's burning it up fast. What's a greedy girl to do? Be careful what she wishes for… × Added to Cart List Price $6.99 Your Cart ( items) Cart total Continue Shopping CHECKOUT NOW Choose a format: Trade Paperback eBook More Formats Hardcover Choose a format: Trade Paperback Trade Paperback Hardcover eBook Margaret K. McElderry Books | 192 pages | ISBN 9781442403048 | June 2010 | Grades 3 - 7 | Lexile ® 730 Add to Cart Buy Simon & Schuster Add to Cart Amazon Barnes & Noble Books-a-Million IndieBound List Price $6.99 In Stock: Usually ships within 1 business day Browse Related Books 3rd Grade | 4th Grade | 5th Grade | 6th Grade | 7th Grade Age 4 - 8 | Age 9 - 11 | Age 12 and Up Lexile ® 691 - 790 Children's Fiction > Family > GeneralChildren's Fiction > Science Fiction, Fantasy, MagicChildren's Fiction > Social Situations > General Buy from another retailer Amazon Barnes & Noble Books-a-Million IndieBound Get a FREE eBook when you join our mailing list. Plus, receive updates on new releases, recommended reads and more from Simon & Schuster. Email Address Free eBook available to NEW subscribers only. Offer redeemable at Simon & Schuster's ebook fulfillment partner.Offer expires in three months, unless otherwise indicated.See full terms and conditions and this month's choices. More Books from this Author Sand Dollar Summer By Kimberly K. Jones By Kimberly K. Jones Sand Dollar Summer Twelve-year-old Lise watches her safe world fall apart when her strong, self-reliant mom is injured in a car accident. To recuperate, Mom takes Lise and her bright little brother to live in a rattletrap house on the beach in Maine for the summer. Although her mother grew up there, this is Lise's first experience with the ocean. She's terrified by what may be lurking in the cold depths and confused by the ways that Maine is changing her mother. As secrets from the past start spilling... Read more about this book Read more About the Author Photograph courtesy of the author Kimberly K. Jones BECOME A FAN BOOKSAUTHOR REVEALED Related Websites Kimberly K. Jones's Official Site www.kimberlykjones.com