text:
|The influence of fruit and vegetable consumption and genetic variation on NAD(P)H:quinone oxidoreductase (NQO1) phenotype in an endoscopy-based population.
|Tijhuis, M.J.; Boerboom, A.M.A.; Visker, M.H.P.W.; Camp, L. op den; Nagengast, F.M. ; Tan, A.C.; Rietjens, I.M.C.M.; Kok, F.J.; Aarts, J.M.G.A. ; Kampman, E.
|Publication year:
|Nutrition and Cancer-An International Journal, vol. 60, iss. 2, (2008), pp. 204-215
|Publication type:
|Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/68313
|From natural philosophy to science
UMCN 1.2: Molecular diagnosis, prognosis and monitoring
UMCN 1.5: Interventional oncology
|Antieke en Middeleeuwse Wijsbegeerte
Health Evidence
UMCN Extern
Engelse taal en cultuur
|Former Organization:
|Epidemiology, Biostatistics & HTA
|Journal title:
|Nutrition and Cancer-An International Journal
|vol. 60
|iss. 2
|Page start:
|p. 204
|Page end:
|p. 215
NAD(P)H:quinone oxidoreductase (NQO1) is an inducible detoxification enzyme relevant for colorectal cancer biochemoprevention. We evaluated the influence of recent fruit and vegetable (F&V) consumption and polymorphisms in NQO1 and transcription factor NFE2L2 on rectal NQO1 phenotype and also whether white blood cell (WBC) NQO1 activity reflects rectal activity. Among 94 sigmoidoscopy patients, we assessed F&V consumption by dietary record and determined the NQO1 c.609C > T and g.-718A > G and NFE2L2 g.-650C > A, g.-684G > A, and g.-686A > G polymorphisms. NQO1 mRNA level was measured in rectal biopsies and NQO1 activity in rectal biopsies and WBC. Consumption of F&V did not yield higher mRNA level or activity but rather appeared to have a repressive effect. Rectal activity was higher among NQO1 609CC-genotypes as compared to 609CT-genotypes (P < 0.0001; 609TT-genotypes were absent), whereas mRNA was higher among 609CT-genotypes (P < 0.001). mRNA and activity correlated among NQO1 609CC-genotypes (r = .50, P = 0.0001) but not among 609CT-genotypes (r = .14, P = 0.45). The NFE2L2-684A-allele was associated with higher mRNA levels (P = < 0.05). The other polymorphisms did not affect phenotype significantly. WBC and rectal activity did not correlate. In conclusion, genetic variation, especially the NQO1 609C > T polymorphism, is a more important predictor of rectal NQO1 phenotype than F&V consumption. WBC NQO1 activity is not a good surrogate for rectal activity.


text:
If Manny Pacquiao was an American where would he rank now in American lists with all
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Originally Posted by
Well know people who did not even make it at the Olympics and never faced international competition and had 100% staged careers like their professional career was a Hollywood movie enjoy mad respect and stuff in the American lists!
So let's say Manny is an American man from a minority background(Asian American,Mexican,African American,which automatically means NONE IN THE MEDIA OR FAN BASE would dare to make so racist jokes against him or his race, cause there would be riots ala L.A. 1992 or OJ Simpson case,Oprah calling Obama (LOL) etc) where does he rank in All time great lists right now?2 probably?Maybe to some even 1?
IMO I think the way he carries himself professionally in and out of the ring is what boxing truly needs today. If he were an American, he would definitely be more of a likeable person and many Americans would greatly overrated him, maybe even rank him higher than some of the all time greats like Armstrong or Ali. Americans are always looking for a new hero, and had Manny been an American, he would be considered the best American athlete today, better than Lebron or Kobe. Because Pacquaio broke records that has never been done before.
America is a Nation populated by ALL nationalities and ethnicities.
Only the Native America was here when WE, from everywhere came here with the dream of Freedom and Happiness.
There's millions of American-Pilipinos and money makes Manny American, so to answer you question. NO, HE would be exactly where He is.
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subset: commoncrawl


text:
Be careful near the monument — often home to a beehive.
Arroyo Seco Loop off Highway 79
The Canyoneers 1:30 p.m., Sept. 20
In Edward Albee's evolutionary comedy, Nancy and husband Charlie did everything society demands: married, had children and grandchildren, worked hard - and now face the unknown. Enter Leslie and Sarah, human-sized sea creatures with the same dilemma. In the long second act, the quartet learns to face tomorrow. Director Kim Strassburger gives the production a much-needed balance between the real and the absurd (though the characters do go on). Wearing Shirley Pierson's excellent costumes, Justin Lang and Amanda Morrow excel as the creatures, their movements most of all. As Charlie, Jack Misset could abandon a foggy, James Stewart voice. Dana Case plays Nancy with gentle persistence and pitch perfect deliveries. Although the visuals are a delight, there's less here than meets the ear.
2787 B State Street, Carlsbad, 92008
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text:
A radical Islamist group has claimed responsibility for a deadly suicide car bomb attack on the UN compound in the Nigerian capital, Abuja.
The blast left at least 18 people dead and more trapped inside.
Witnesses reported that the bomb went off after a suspect forced his way through security and rammed the car into the building.
Parts of the first two floors were blown out and rescue workers scrambled to rescue those left inside.
Boko Haram has been blamed for scores of bombings in recent months.
'So far, we have 18 dead and eight injured,' Mike Zuokumor, police commissioner for the Federal Capital Territory, which includes Abuja, told journalists.
'I cannot say how many people are still in the building. The rescue operation is still on', he added.
UN chief Ban Ki-moon strongly condemned the attack and said 'considerable' casualties were expected.
Mr Ban said staff for 26 UN agencies and departments were in the building.
'This was an assault on those who devote their lives to helping others,' he said. 'We condemn this terrible act utterly.'
He said the attack highlighted how the global body was increasingly becoming a 'soft target' for extremists.
One UN staff member said people had been trapped in the building that sustained heavy damage.
'I don't know what is going on. Many people are still trapped upstairs and we need a crane to bring people down,' the UN staffer who did not want to give her name said in the aftermath of the explosion.
Two cranes were later brought to the scene and rescue workers sought to free those trapped on the upper floors.


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This 4-week program gives you a day-by-day breakdown of what workout to do everyday, 5 days a week. These workouts alternate between circuit training and cardio workouts, allowing your body to burn fat, build muscle and recover properly.
All of the exercises in the full body circuit workouts use multiple muscle groups at one time, so you burn the maximum number of calories in the least amount of time.
The full body circuit workouts don't require any equipment, and can be performed anywhere! The same goes for the cardio workouts. I suggest doing anything that gets your heart rate up! This can be done on a cardio machine, using workout dvd's, swimming laps in a pool, or even a Dashing Dish Cardio Workout!
If you follow this 4-Week Boot Camp, in combination with a healthy diet, I can pretty much guarantee that you will notice a difference in your body composition!
It's Your Last Week!!! Way to GO!!! Hope you have enjoyed the workouts and the results!
The Dashing Dish Membership gives you the essential resources you need to maintain a healthy lifestyle. Plan your meals, keep a grocery list, and enjoy access to our full catalog of over 700 healthy, delicious recipes.
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October 4, 2014
On Sept. 28, Gov. Jerry Brown signed the California Fair Sentencing Act (SB 1010) authored by Sen. Holly Mitchell, D-Los Angeles. The legislation eliminates the groundless disparity in sentencing, probation and asset forfeiture guidelines for possession of crack cocaine for sale versus the same crime involving powder cocaine that has resulted in a pattern of racial discrimination in sentencing and incarceration in California. The law takes effect in January.
September 4, 2014
On Aug. 29, the California Assembly approved AB 885 by Assemblymember Tom Ammiano, passing a milestone measure to limit trial misconduct by prosecutors. The bill would allow judges to inform a jury when a district attorney has been found to have intentionally withheld significant evidence. The bill's next step is to go to Gov. Jerry Brown's desk.


text:
Albertville Turns to Charter TV® for Entertainment
Experience NASCAR like you would in person when you watch Jeff Burton and Greg Biffle trade paint in HD from Charter Cable; it's like you're right in the middle of all the action. And with HDTV specials in Albertville from Charter TV®, you'll also enjoy cutting-edge movies and exclusive entertainment programming, turning your living room into a studio theater. Get into the game and see what almost 14,382 of your Albertville neighbors have already discovered — HDTV deals deliver world-class entertainment at rates friendly to your budget.


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We need a bump of water to clear the weeds, so far that is not in the forecast.
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text:
Step By Step: Carrot cupcakes
Since everybody is crazy about cupcakes these days, and nearly everyone else is trying his/her hand at making one, here's a basic recipe for a moist, hearty carrot cupcake with a thick coat of icing.
Ideally, cream cheese frosting is best for carrot cupcakes. However, this recipe calls for boiled icing so you can easily decorate the cupcakes. Swirl it, twirl it or make a hole in the middle and add fruits—the only limit is your imagination. You can then top the cupcake with candies, chocolate syrup, rice crispies or what-have-you.
"Carrot cakes are simpler and faster to bake," says baking enthusiast Rudy Milay. "They're easier to style, too. The boiled icing can also be done with chocolate cupcakes."
Milay—who has done wedding and birthday cakes for celebrities such as Gloria Diaz, Tito Sotto, KC Concepcion, Pops Fernandez, Connie Reyes, Richard Gutierrez and even US Embassy consuls—adds that royal icing is another option for frosting cupcakes. However, royal icing dries quickly, though it has a shiny, hard matte finish. It's often used for intricate piping decorations.
If you want to try royal icing for your carrot cupcake, here's the basic recipe: 3 egg whites, 5 c powdered sugar, ¼ tsp cream of tartar. Beat all together in the mixer for five minutes.
On Christmas, you can put up a small dessert business starting with these cupcakes. Milay says the actual cost for each cupcake is about P7, but with a selling price of P20. Most ingredients are available in supermarkets. For cheaper and wholesale purchases of cinnamon, flour, baking soda and other baking supplies, Milay goes to Killion store in Quiapo; Jubilee store on 8th Avenue in Cubao, QC; or at Chocolate Lovers in QC.
Carrot Cupcake
- 1 ½ c salad oil
- 2 c granulated white sugar
- 3 pcs eggs
- 1 c crushed pineapple
- 1 c chopped walnuts
- 3 c grated carrots
- 3 c all-purpose flour, sifted
- 1 tsp salt
- 1 tsp cinnamon
- 2 tsp baking soda
- 1 tsp vanilla
Boiled icing:
- ½ c water
- 2 c white sugar
- ¼ cream of tartar
- White eggs from 6 eggs
- 1 c powdered sugar
- Preheat oven to 350°F. Line standard muffin pan with baking cups. Using an electric mixer, beat eggs at full speed for five minutes.
- Add sugar, oil and vanilla. In a separate bowl, combine flour, baking soda, salt and cinnamon so they're evenly mixed, then add the mix into the egg mixture and stir well. Fold in walnuts and crushed pineapple.
- Fold in grated carrots.
- Gently mix all together. Spoon into baking cups.
- Bake for 40 minutes. Let it cool.
- To make icing: Boil water, white sugar and cream of tartar. Set aside. Using an electric mixer, beat white eggs to full speed. Then, gradually add the sugar mixture into the beaten white eggs. Add powdered sugar. Mix well. Add liquid food coloring drops to dye it red, blue, violet, yellow, etc. Mix again. Transfer icing into a piping bag with a star tip.
- 7. Start decorating your own cupcake.
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text:
City Council member moves to end board's pay
The majority leader of the Providence City Council said he wants to strip members of the city Board of Licenses of their pay.
Seth Yurdin said he's upset because the board decided not to revoke the license of Cheaters after a 15-year-old girl was found dancing there.
Unlike most city boards and commissions, each of the five members of the Board of Licenses receives a salary of about $20,000 a year.
A long investigation by city police officers and the licensing board recently uncovered prostitution at the club and a revealed that a 15-year-old girl had been employed as a dancer.
Yurdin said board members shouldn't receive salaries because they're failing to do their jobs, which is protecting the safety of the public at large.
"The board found that there was a 14-year-old girl hired. The board found that there was prostitution taking place, and I think that we really have to act in the strongest way to protect children, to send a message that this type of thing won't be tolerated in the city. Those officials are charged with doing that," Yurdin said Wednesday. "I think it's clear that the wrong message has been sent."
The Board of Licenses did take action against Cheaters, shutting the club down for 45 days and fining the owners $5,000.
Yurdin said he will present his ordinance to revoke the salaries Thursday night.


text:
Pioneer Fest revived under new management
A little bit vintage and a lot of country describes this year's Pioneer Fest, coming up on Saturday, Aug. 16, from 11 a.m. to midnight at Pioneer Park in Perham.
Now under new management by the History, Arts and Cultural Association of East Otter Tail County, the festival is being revived and refreshed with input from the public.
The popular evening concert and dance established in years' past will continue this year. The headliner will be The Dan Brekke Band. Brekke, a young rising star featured at Jasper's Theatre in Park Rapids, provides a stomping good time, rousing crowds with his lively version of "Orange Blossom Special."
Opening the evening will be Oakland After Hours, by Jeff Oakland of New York Mills. Other musical guests will entertain when the indoor/outdoor beer garden opens at the Grandview Ballroom at 5 p.m.
Daytime activities between 11 a.m. and 5 p.m. will include a tractor pull and antique tractor show, classic cars and a vintage and antique doll sale, bake sale and beer stand. Families are invited to bring their dogs along during the day to explore the 25-acre park and have a picnic.
"Fun, free activities, especially those where you can bring your dog, are getting hard to find," said Darla Ellingson, CEO of the History, Arts and Cultural Association. "We'll have free outdoor games like bean bags and Frisbee; you can bring a picnic, or buy lunch here."
The Lakes Country Mountaineers will be having their annual rendezvous campout next door, and guests of Pioneer Fest are welcome to view black powder shooting demonstrations throughout the day.
"Many people have asked about our rumored antique doll sale," said Ellingson. "It will take place inside the café building starting at 11 a.m. Everything is priced to sell below our researched value, so collectors will want to come early. Bargain hunters – check later in the day for additional discounts."
Outside alcohol is not allowed in the park. Dogs should be kept on a leash and away from tractors, and owners will be expected to clean up after them. Dogs are not allowed in buildings, on black powder shooting grounds or in the evening beer garden.
There will be stations where participants can give input on future festivals and activities at Pioneer Park. With community input, organizers hope Pioneer Fest will grow again in future years.
Pioneer Fest 2014 daytime activities have free admission. There is a $5 donation requested for admission to the evening concert, dance and beer garden. Hot dogs, snacks, dessert, pop, beer and wine coolers will be available for sale during the day, and barbequed brats, burgers and snacks will be for sale in the evening, along with a full bar.
For more information, contact Darla Ellingson at firstname.lastname@example.com or 346-7678.


text:
Single point diamond dresser.
Carat size: 0.50
Shank diameter: See drop-down box below.
Shank length: See drop-down box below.
Application: Dressing of grinding wheels upto 180mm diameter.
More information? You can speak with one of our representatives toll-free in the U.K. Monday-Friday between 8.30 a.m. and 5.00 p.m. on 0800 027 1928 or +44 (0) 1945 585500.


text:
Separate names with a comma.
Discussion in 'Trucks and Trailers' started by DiPop, Oct 26, 2013.
I like the diamond plate idea.
diamond plate would like nice, but it's totally unnecessary.
These trailers are designed to be used for what they are being used for... putting machinery inside them.
I have never used an enclosed trailer for mowers, but the number of box trucks I have used for this purpose in fleets with countless variable employees over the years is staggering... never once did we have issues with the inside of the trailers.
Ditto goes for every Uhaul/penske truck out there.
I did have an enclosed trailer for my snow machines, until I sold it last winter.
Let me tell you, if ANYTHING was going to tear up the inside of the trailer it would be hot dog riders, on 170 hp sleds coming in sideways, slipping allover half melted snow at 4000 rpms with razor sharp carbides instead of tires...
Seriously... it's a non issue.
I sold the trailer for a $100 less than I bought after using it for a year... it's all good.
(I just mooch every one else's trailer instead now)
Well thanks for the input I'll have to think about if it's worth or not
Posted via Mobile Device
The trailer should be lined in plywood and will resist occasional bumps and such. Is yours not lined?
You need some type of tie-down system for your machines. Are you not planning on using one?
My setup. I rarely have the small ZTR onboard and have my pushers up there, strapped to the FasTrap chocks.
Thank you.
That stuff is all Gladiator product. I added a metal rod below each track and just made up some cheap bungees to hook from there to each "S" hook. That keeps tension on the hook, so the pieces stay hung. Vertically hanging things made much more sense than the common racks. I can enter through the side door and just grab what I need. Horizontal racks would've meant using up an entire wall for just a few handhelds. If the mower(s) are loaded, getting to that stuff would be a major PITA. All my rakes/shovels/etc are down that right wall. I still have the left wall for more tools, in the future. Plus, Gladiator offer a huge assortment of hooks that allow hanging just about anything.
I really like your setup. I'm doing something very similar with my 7' x 16' trailer
I have shelves where you have your wall cabinet and I have my trimmers and edgers in the same spot. My backpack blower is on the right as soon as you come up the ramp. I'm using hooks I found at Home Depot. As soon as I get it all done I'll post some pictures.
Is that just paint on the floor or did you put something else down?
I put mine up front, because I wanted to be able to close up my trailer, when the mowers are reloaded, and work out of one door. I never leave my rear door down, as I don't want people driving by seeing everything. I mow in some less-than-stellar neighborhoods. One LCO had the wheels stolen off the opposite side of his trailer, when he went around back of a property. I installed splined lugs on my complete outfit, to help alleviate that. Places like that sway the closed versus open trailer argument.
That's Pittsburgh Paints Revitalize coating. It's very thick, like a milkshake, and can be mixed in a limitless number of colors. It contains anti-slip media and is extremely durable. It's designed to coat wood decks that have a compromised surface. It'll fill cracks, holes, etc. I oil-base primed and painted the walls and brought the Revitalize up the wall a couple inches to seal that joint and the floor. I regularly scrub out the trailer with soap and water. The lines you see in the pic are residue left from hauling 288 landscape edgers. Anyway, I paint for a painting contractor, part time, and we've used about everything on everything. This stuff truly works, I really like the product, and would highly recommend it.
This is emptied out. My backpack sprayer, now, hangs under the cabinet.
Here is a link to my thread that has pictures of my trailer…


text: I know that there is a lot of threads on these light meters, but I just wanted to give my two cents (US). I have had just about every spot meter there is out there. I have 3 now and like them all, but two are Zone VI meter and one Pentax. I was reading Black and White photography mag. from UK, (you guys know how to put a mag together), and they had a article on meters and all seem great but what got my eye was the Gossen which can be used with the Zone system. I did some further research and got very excited about the meter. Went on e-bay to find that no one had used, (I didn't know till later it was introduced two years ago.) so I went to B&H and found that the price was much higher than I thought it would be. Since I sold all my Pentax 67 and lens I have some extra money and made the commitment. This will be one of the few new items I have purchased as photo equipment goes. after a couple of days of working with it I have found that it fits my style using my 8x10 and 8x20 camera. I can easily see how my developing is going to be done and making notations easy. I know so many feel the sekonic is a better meter but I have had their best and fought all the time to translate into the Zone system. I live and die by the zone system and have for almost 40 years and change now is not going to happen. take a good look at this meter and I think you will be convinced it is the one for Large format photographers.


text:
Understanding how precious MacBooks are to their owners, Blackbox Case has just launched this set of wooden MacBook Pro cases. Lighter than you might expect, the cases weigh in at around 1.5 pounds. Made with maximum love and respect for both their product and craft, each case is oiled, sanded, rubbed down ad even individually numbered by hand. Ensuring that consumers are welcomed into the Blackbox family, every purchase is complete with a welcoming card. Available to house either a 13 or 15inch MacBook Pro, the cases are now available, directly through Blackbox Case.
Source: Notcot


text:
This page is part of the Warren
County Ohio GenWeb project
You are our [an error occurred while processing this directive] visitor since 28 October 2004 -- thanks for stopping by!
Transcription contributed by Arne H Trelvik 10 June, 2003
|The History of Warren County Ohio , Part III.
History of Warren County, Chapter V. Early Schools and Churches
(Chicago, IL: W. H. Beers Co, 1882; reprint, Mt. Vernon, IN: Windmill Publications, 1992)
Related Links:
Schools and churches were established in Warren County almost as soon as a neighborhood of settlers had built their log cabins and begun their clearings. The early school and meeting-houses were rude log buildings, but the instruction was as lasting and the prayers were as fervent as in the most stately school building or cathedral of the cities. The first school in the county of which we have any record was taught by Francis Dunlevy, afterward first President Judge of the Circuit of Southwestern Ohio, and was commenced in 1798, just west of the site of Lebanon. It was attended by youth from four or five miles around. Among the earliest pupils of this school was a black-eyed boy, who gave his age as four years and his name as Thomas Corwin.
Francis Dunlevyy was a scholar with considerable attainments, both in languages and mathematics. As early as 1792, he had opened at Columbia what was probably the first classical school between the Miamis. This school was conducted in connection with John Riley, afterward of Butler County, Ohio. Dunlevy taught the ancient languages and higher mathematics; Riley, the common English branches. This school was continued until 1794, when Wayne's victory over the Indians permitted many of the inhabitants of Columbia, who had hitherto been prevented from so doing, to occupy their lands up the country. By this means the place was almost depopulated, and the school was given up.
Mr. Dunlevy afterward taught school for a time at "The Island" as then called, some ten miles up the Little Miami, and in the year 1797 removed to the neighborhood of Lebanon, as now known, and opened a large school at a point half a mile west of the center of the present town. But Lebanon was not laid out until 1802, and when the school was opened the present site was entirely in the woods. Besides the common branches, the ancient languages and the higher mathematics were taught. The school was continued until the year 1801, when MR. Dunlevy moved it to the northwest about two miles, where many of his former pupils attended. While there, he was elected a member of the Territorial Legislature, and was succeeded as teacher by David Spinning. A school was taught regularly in the same place until 1825.
Other schools were taught in the country around Lebanon at this early period, among which may be mentioned one conducted by Matthias Ross as early as 1801, 1802 or 1803, near the present site of Ridgeville; a large school taught by Thomas Newport, about one mile north of Lebanon, from 1805 for many years; and the first school at Deerfield, taught by the late Ignatius Brown, about the year 1800.
The first school taught in Lebanon after it became a town, was conducted by Enos Williams, a pupil of Francis Dunlevy, in 1801, 1802 and 1803. The branches taught were reading, writing, spelling, arithmetic, geography and English grammar.
The first schoolhouses were built of logs – not by taxation, nor
subscriptions of money, but by the labor of the settlers. On a fixed day,
the neighbors assembled at the chosen site and the work was done. The
ample fire-place occupied nearly the whole of one end of the structure.
The furniture was as rude and simple as the building. A hewed slab or
puncheon, slanting from the walls, extended on three sides of the room
as the writing desk for the whole
|school. The seats were of slabs, and without backs. The pupils
sat with their faces to the wall, the teacher occupying the central part
of the room.
While some of the early schools may be said to have been good schools, taught by intelligent teachers, other, and perhaps the majority, afforded but inferior facilities for learning. In some of them, the only text-books were Webster's spelling book, the New Testament or the English reader, and Pike's or Diebold's arithmetic. Grammar and geography were not generally taught, and arithmetic usually only as far as the rule of three. For years, it was customary, in indenturing an apprentice, to require the master to provide for the education of the minor only so far as to teach him "to read, write and cipher as far as the rule of three." The examples for practice in the arithmetics were given almost exclusively in pounds, shillings and pence. More importance was attached to the spelling of all the words in the spelling book than those which are ordinarily used in writing, and spelling matches were were common. The teacher wrote the copies for the writing lesson, and the making and mending of quill pens was an essential part of the teacher's work.
Francis Glass, author of the Life of Washington in Latin, a man of rare attainments in the ancient languages, was for several years a teacher in different localities in Warren County. He was educated in Philadelphia, and came to the Miami country about 1817. J. N. Reynolds, who edited Glass' Life of Washington and secured its publication, gives, in the preface of that work, some account of the author. Glass was a poor man with a large family, and all his worldly goods and chattels could not have been sold for $30. The Life of Washington seems to have been commenced in Warren County, and completed in Dayton. Reynolds was his pupil in the winter of 1823-24, in some part of Warren County, but its exact locality he does not give. The school house "stood on the bank of a small stream in a thick grove of native oaks. The building was a low log cabin with a clapboard roof, but indifferently tight; all the light of heaven found in this cabin came through the apertures made on each side in the logs, and these were covered with oiled paper to keep out the cold air, while they admitted the dim rays." Here he had about forty pupils, only about half a dozen of whom were studying Latin and Greek. His book was published in 1835, by the Harper Brothers, after the death of the author, with the following title: "Georgii Washingtonii, Americæ Septentrionalis Civitatum Fæderatarum Præsidis Primi, Vita. Francisco Glass, A. M. Ohioensis."
NOTICE: All documents and electronic images placed on the Warren County OHGenWeb site remain the property of the contributors, who retain publication rights in accordance with US Copyright Laws and Regulations. These documents may be used by anyone for their personal research. Persons or organizations desiring to use this material, must obtain the written consent of the contributor, or their legal representative, and contact the listed Warren County OHGenWeb coordinator with proof of this consent.
This page updated
5 February, 2013
© 2003-2004 Arne H Trelvik All rights reserved


text:
When a child dies while participating in sports, should parents be blamed?
Sunday's death of Grand Prix motorcycle racer Peter Lenz, of Vancouver, Wash., has sparked debates about parenting and motorsports. Lenz, who had recently turned 13, became the youngest racer to die at the century-old Indianapolis Motor Speedway. Lenz was hit by another driver, 12, after falling off his bike during a warm-up lap.
Almost immediately, a blanket condemnation of motorsports for kids started flying. How can parents allow children to do something so dangerous when they can't even get a driver's license? This story asked the question whether kids are old enough to participate in extreme sports.
"It blows my mind that none of the adults around him put his well being first," wrote John Canzano, a columnist for the Oregonian newspaper in Portland, Ore. "This ultimately rests with parents who should tell children who want to participate in dangerous activities, 'I love you too much to let you risk your life.'"
Really? Then should we keep our kids from playing football, baseball or basketball, swimming, going to the beach? Maybe we should just keep them indoors to protect them from any risk at all. "With youth sports ... there are injuries from time to time and there are fatalities from time to time," speedway spokesman Fred Nation said. "But when you have them in an organized sport, in a controlled environment and safety people around, we think that's a lot safer than having kids running around on four-wheelers through the woods."
It's already been two years since my son, Isaak, started racing quarter midget cars at the age of 5. Would I pull him out now because racing is dangerous for kids? Absolutely not. Isaak drives almost 40 mph around a 1/10-mile asphalt track with more than half a dozen other drivers. Yes, it can be dangerous, and he's been in many wrecks and crashes. But he's well-protected: double-layer Nomex fire suit, SFI-rated helmet, gloves and neck brace, plus an extra helmet restraining system, five-point seatbelt, and a chassis frame around him. He receives training regularly. His family/crew works hard to keep the cars in top shape.
Granted, Lenz was on a motorcycle and lacked the protection Isaak has. But for their class of racing, they had the best safety equipment. Is a 13-year-old too young to race bikes? I think he and his family understood the risks as do most racers. Driver safety is always a top priority. But accidents happen.
I do hope this tragic event will prompt all motorsports sanctioning bodies to review their safety policies. But to condemn and vilify an entire sport because of a rare incident is wrong.
~ Lyra Solochek, Times mom
[Photo: Peter Lenz]
Follow us on Twitter @WhoaMomma


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Health Department Warns Of Fake Inspectors
The South Central District Health Department is advising restaurant owners that there may be someone out there claiming to be inspectors who are not. The health district has had reports from several restaurant operators, mainly in the Wood River and Mini-Cassia areas, who claim a person will contact them to say there was a complaint about their food. When the fake inspector shows up they ask to sample the food and in some cases ask for unrelated business information.


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This game was classified by the community with the following category scores - Violence=1/3, Sex=1/3, Mature Content=1/3. Heart and Mind are travelling across Poland in order to see the Championship. Help them to hit the ball into the goal. The fewer movements you make, the more points you get for each goal. Collect bonuses in order to get additional points. You have to carry out additional tasks at 4 special levels.
Buy Xbox content on Xbox.com. Your Xbox 360 console will automatically download the content next time you turn it on and connect to Xbox Live.Learn More


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9/30- Dead Animal Show
"The burnt corpse of an earthworm curled into itself like a rusty fishhook." -From "A Slaughter of Earthworms" by Bob Pfeiffer
9/23- Literary Allusion Show
"I don't want to go to Hemingway's house, let him come to mine, walk in and we'll do The Killers at my kitchen table…" -From "Hemingway's House" by Gerald Stern
9/16- Sports Show
"Let's say we slug a brew everytime the Canadians score." – from "Hockey" by Mike Dockins
9/9- Body Show
"You good for nothing spleen. Whatever it is you do, screw you." -From "To Another Her with Love" by Travis Denton
9/2- Pop Culture Show
· by admin · in Primary Menu Log, Shows, Uncategorized
"Dorothy's broomstick braids slap him in the mug. Quit your yapping and give me a munchkin for lunch." -From "Deconstructing Dorothy" by Nina Corwin


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United Spinal Joins Largest-Ever Web Expo for People with Disabilities and Chronic Illnesses
Sep 12, 2012, 09:10 ET from United Spinal Association
NEW YORK, Sept. 12, 2012 /PRNewswire-USNewswire/ -- United Spinal Association's membership division, National Spinal Cord Injury Association (NSCIA), will join the Allsup True Help® Disability Web Expo on Thursday, Sept. 27, from 9 a.m. to 4 p.m. CST.
(Logo: http://photos.prnewswire.com/prnh/20110413/MM82757LOGO)
NSCIA will share resources to empower people with disabilities and chronic illnesses so that they can achieve greater independence and a more active lifestyle.
This free online event is anticipated to be the largest-ever virtual web experience geared to meeting the needs and interests of people with disabilities and chronic illness. Caregivers, healthcare providers and the general public also are invited to attend.
"At the United Spinal booth, attendees will find community resources available through NSCIA and national network of chapters; accessible travel options; advocacy tools; and tips on choosing the right wheelchair and mobility equipment," said Marlene Perkins, VP of Corporate and Community Relations at United Spinal.
"We are thrilled that United Spinal will join us in providing an educational, entertaining and easily accessible forum for individuals with disabilities and their caregivers," said Tai Venuti, Allsup manager of Strategic Alliances.
"People regularly reach out to United Spinal for their expert guidance and support on overcoming the challenges of living with spinal cord injuries and disorders. The Allsup True Help Disability Web Expo provides a dynamic and interactive environment to connect individuals with the valuable programs and resources United Spinal offers," she added.
The Allsup True Help Disability Web Expo will serve as a one-stop, live exhibition of representatives on numerous topics, videos, resources and more. Participants will be able to:
- Interact with experts through live chats, workshops, Q&A sessions and one-on-one discussions.
- Gather information on accessing benefits, community resources and other services from health and financial organizations.
- Share thoughts, ideas and concerns via surveys, chats and message boards.
- Network with fellow United Spinal members.
- Register for prizes.
United Spinal is joined by more than a dozen leading nonprofit organizations and experts in health and wellness, advocacy, disease treatment and support, Social Security Disability Insurance, veterans' disability, financial planning, disability employment, Medicare and health insurance.
To register for the Allsup True Help® Disability Web Expo, please visit https://allsup.6connex.com/portal/truehelpexpo/login. For additional information, contact Tai Venuti, MPH, at email@example.com or (618) 236-8573.
About United Spinal Association
United Spinal is a national 501(c) (3) nonprofit membership organization formed in 1946 by paralyzed veterans and is dedicated to improving the quality of life for all Americans with spinal cord injuries and disorders (SCI/D), including multiple sclerosis, spina bifida, ALS and post-polio. It played a significant role in writing the Americans with Disabilities Act, and made important contributions to the Fair Housing Amendments Act and the Air Carrier Access Act. Membership is free and is open to all individuals with SCI/D. United Spinal was instrumental in getting New York City to create sidewalk curb ramps and accessible public transportation that has been used as a model for many United States cities.
Available Topic Expert(s): For information on the listed expert(s), click appropriate link.
Marlene Harmons-Perkins
SOURCE United Spinal Association


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Rs. 299+ shipping charges
Rs. 299+ shipping charges
The present book is the result of his imagination at the age of 80 and devoted to Youth Power, their love and friendship and their urge to achieve desired goals in life. According to him, life without love and friendship may not flourish as both are life-giving flames. Coming together, joining hands, celebrating and feeling the warmth of it all, there can be no substitute. Each story is about lovable human beings, their meeting and self-discovery, their love and fulfilment. For them life assumed meaning and purpose when they were devoted to achieving things.
After serving the Central Government for 36 years in different capacities as Information Officer, Research Officer, Assistant Director, Deputy Director (Publications), Editor and after retirement as Consultant and Documentation Expert with UNICEF, Shri G. Sivaswamy returned to his native place in Kerala and has been engaged in social service and writing books. He is the founder-Chairman of Bharatiya Vidya Bhavan, Wadakanchery Kendra, President of Kerala Brahmana Sabha and is a well-respected Wadakancherian, a person whose counsel is sought in the matters of the town. A forceful writer, talker and a great traveller, his books and the periodicals edited by him are popular amongst a wide arena of audience in Kerala, India and the world.
His major publications include several books in English and Malayalam such as:
Contact Address: Sowbhagya, Girls High School Road, Wadakanchery, 680582 Kerala
e-mail email@example.com Phone 04884-232790; 230001


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"Dashing, decadent, and deliciously seductive, the notorious Lords of Vice indulge their every desire from dusk until dawn "
Christopher Courtland, Earl of Vanewright known around London as "Vane" is the very picture of a rich, handsome ladies' man.Read more...
- $7.99
Customers Also Bought
"Dashing, decadent, and deliciously seductive, the notorious Lords of Vice indulge their every desire from dusk until dawn "
Christopher Courtland, Earl of Vanewright known around London as "Vane" is the very picture of a rich, handsome ladies' man. Why shackle himself to just one lady when he's free to sample them all? In spite of his own mother's attempts at matchmaking, Vane has sworn to stay single. Until he has a chance run-in with Miss Isabel Thorne
A modest and refined beauty, Isabel is a lot more brazen than she appears. When a pickpocket tries to make away with Vane's bejeweled snuffbox, Isabel attempts to thwart his escape and manages to steal Vane's heart. But the harder he tries to seduce the sharp-tongued, strong-willed Isabel, the more she resists. Now it's up to this tried-and-true bachelor to find a new way to play the game or risk losing the one woman who's ever captured his heart."
- Publisher: St. Martin's Press
- Publish Date: January 2012
- Page Count: 304
- Dimensions: 6.6 x 4.1 x 0.9 inches
- Shipping Weight: 0.3 pounds
Series: Lords of Vice
Related Categories
Books > Fiction > Romance - Erotica
Books > Fiction > Romance - Historical - General
Books > Fiction > Romance - Historical - Regency
Publishers Weekly® Reviews
- Reviewed in: Publishers Weekly, page .
- Review Date: 2011-11-28
- Reviewer: Staff
Hawkins's fourth Lord of Vice Regency romance (after After Dark with a Scoundrel) is a lighthearted and familiar story of lovely and impoverished sisters seeking their fortune. When Lady Netherley meets Isabel and Delia Thorne, she sees them as a way to trick her wild son into marriage. Dutifully, Isabel helps throw Delia and the earl of Vanewright together, hoping her sister can make a match that would benefit the family financially, with only a few wistful thoughts for her own prospects. Of course Vanewright is attracted to serious Isabel instead of saucy Delia, and Isabel tosses caution to the wind for one night of passion. But Lady Netherley had Isabel in mind for her son all along, and Vanewright is furious to learn he's been set up. Plot developments are telegraphed well in advance, but Regency fans will enjoy the bold heroine and rakish hero. (Jan.)


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Legendary rockers Survivor and John Waite will be bringing down the house in a one night only special concert.
The show starts at 7:30pm on Friday, May 17th, and is located at the Egyptian Theatre, at 135 N. Second Street in DeKalb. For tickets or more information, please call (815) 758-1215 or visit http://egyptiantheatre.org.


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It was some time before Peter Warzybok believed he was looking at a northern gannet. The large birds are distinctive, with creamy plumage and black-tipped wings—but they aren't supposed to be anywhere near the Farallon Islands. Their range is the northern Atlantic Ocean, separated from the Pacific by various continents and the inhospitable Arctic sea.
"At first I thought it was going to be a red-footed booby or something like that," said Mr. Warzybok, a biologist who lives part-time on the cluster of islands that lies due west of San Francisco. He first spotted the bird during a routine morning seabird survey, and "once I got a good look at it, I got really excited," he said.
The bird, which showed up last April and is still hanging around, is the first northern gannet ever documented in the Pacific Ocean. It created a huge stir within the bird-watching community, and is one in a small string of animal sightings worldwide that have been tentatively attributed to global climate change.
"For a bird that only is found in the Atlantic to show up on the Farallones is pretty extraordinary," said Mr. Warzybok, who works for PRBO Conservation Science, the organization that conducts most biological research on the islands. "Of course the first thing we started talking about is how it got there."
The northern gannet is a seabird that depends on chilly, open water to survive; it is common from Newfoundland to Ireland, and as far south as northern Mexico. Scientists agree it would be impossible for one of these birds to cross the continent. The most probable route Farallon gannet could have taken is north across the Arctic Sea, over the open water that increasingly has been replacing summer ice as temperatures rise.
"It seems pretty coincidental to have all these eastern north-American birds suddenly showing up in the Pacific," said Peter Pyle, a biologist with the Institute for Bird Populations in Point Reyes Station.
Arctic ice reached record lows in 2012, and the Northwest Passage—historically impassible year-round—has been melting open during summers since 2007. As the ice recedes, a relatively direct path between the Atlantic and Pacific Oceans has opened to the aquatic creatures living in the northern parts of both seas.
And they seem to be taking advantage of it. A species of plankton that only lives in the Pacific showed up in the Atlantic after the passage melted open in 2007, according to the National Oceanic and Atmospheric Administration.
Other, larger organisms soon followed suit. In the last few years, a tufted puffin and a gray whale—both previously found only in the Pacific—have appeared half a world away, while an Atlantic eider showed up in Crescent City.
The whale was a particularly impressive voyager. This Pacific mammal was seen in the Mediterranean Sea near Israel in 2010; scientists speculated that its journey—if indeed the whale traversed the Northwest Passage—ended at a logical destination.
Gray whales typically feed off the shores of Canada before they head south and hang a left into their breeding grounds in the lagoons of Baja California. But if a whale overshot the mark, continuing west until it reached the coastline of Europe before heading south, the first major inlet on the left would lead it into the Mediterranean Sea.
The only direct documentation of migration through the Northwest Passage was of two male radio-tagged bowhead whales. These creatures occur in both the Atlantic and the Pacific, and in 2010 one whale from each ocean entered the Northwest Passage when it was largely free from ice.
Both spent the first two weeks in September in the Viscount Melville Sound before returning to their original territory. Because their radio tags showed they crossed paths before turning around, presumably they could have continued on to the opposite sea.
Though the Farallon gannet is the first to be documented in the Pacific Ocean, there were two unconfirmed sightings of a northern gannet in the Chukchi and Bering Seas last year. There is no proof that this was the same bird that eventually wound up here in California—but it would make sense, Mr. Bradley said.
"The only other way it could have come is if it actually rode a ship through the Panama Canal and came up that way," he added. "Either way is pretty extraordinary."
Now that it is here, the bird seems to have settled in. When Mr. Warzybok first saw it in late April he got on his radio to alert his colleagues.
"I said, 'Come up to the lighthouse if you want to see a gannet," he recalled. "But then it took off and flew around the island right by the house; people were able to just walk out the front door and see it fly by."
Within hours, news of the sighting had ricocheted through the California birding community.
Part of the reason for the excitement is competitive. Serious bird watchers keep lists of the birds they've seen in their lifetimes, or in certain states or regions. For birders who have seen northern gannets in the east, it's still a big deal to spot one in California, said Mr. Pyle—who added that he personally had been eager to see it himself, since he's seen the largest number of birds on the Farallones and didn't want to miss adding this rare visitor to his list.
Throughout the summer and fall, whale-watching boats and bird-watching cruises visited the remote islands, hoping for a glimpse of the gannet, which has been spending most of its time on a small spire of stone called Saddle Rock.
Though both Point Reyes and the Farallon Islands are renowned among birders for attracting off-course birds, or "vagrants," the gannet was a particularly exceptional sight.
"Part of everyday life on the Farallones is keeping your eyes open because anything could show up ant any time—but even though we say that, we don't really mean anything," Mr. Warzybok said.
Most vagrants are blown off-course, or perhaps they turn left instead of right in a storm or fog bank. Substantially more vagrants show up in cloudy or foggy weather—but not ones that have never even been seen in the same ocean.
"This individual took an incredible journey to get to the Farallones and then it stayed there," Mr. Bradley said. "It's definitely just an incredibly rare occurrence."
The gannet may have decided to stay on the rugged, rocky Farallones because they resemble the species' nesting colonies back east—right down to the other birds, such as common murres, that nest nearby.
"I've seen [the gannet] land among the common murres and look like it wanted to nest—it was displaying and looking like it wanted to mate," Mr. Warzybok said. "It probably was perplexed as to why there weren't any other gannets around."


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Take a break from your everyday life by going on the Washington DC Weekend Getaway package, which includes two nights' lodging and the DC in a Day Tour.
The DC in a Day Tour will take you to Washington DC's most famous and exciting attractions in one comprehensive, nine hour experience. You will see the FBI building, Federal Triangle, and Supreme Court from the comfort of your tour bus and get to stop at attractions like the White House Visitor's Center, Ford's Theatre, the U.S. Capitol, and the National Air and Space Museum. In total, you will have seen or visited 25 of the most popular attractions in DC! As one of the most historically fascinating places in the US, you can cram all of the greatest sites that every DC visitor should see in one exciting day. Who knew vacations could be so easy?
To finish off your package, you also get two nights' lodging in the DC area. Options range from lodging close to the White House to a more cozy setting in the DC suburbs, so everyone can find what they need!


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SAN DIEGO--(BUSINESS WIRE)--MicroPower Technologies, Inc., the award-winning provider of wireless surveillance solutions optimized for rapid, cost-effective deployment, has been selected as a Top 30 Technology Innovation by Security Sales & Integration Magazine. The leading security trade publication chose the Helios™ solar-powered, wireless surveillance system from MicroPower as one of the most inventive products of 2012.
"We are focused on providing enterprise-class technologies to our integration partners that meet the needs of the most complex perimeter surveillance environments."
SSI columnist Paul Boucherle selected the Helios system as one of his Top Technology picks.
"The Helios system integrates IP video, a unique wireless transmission scheme and solar power to deliver a one-half mile surveillance solution in a clean and easy-to-deploy package," he noted. "By thoughtfully integrating the discrete pieces into a seamless system, the time to design, sell, install and maintain is dramatically reduced, which obviously reduces your risks while improving profits. More importantly, you don't have to pass on project opportunities because of your lack of experience, knowledge or customer budget that may require trenching with electrical work. The components are matched for low power consumption and good network traffic management tools."
The 2012 Top 30 Technology Innovations winners are hand selected by the technology experts at Security Sales & Integration. The awards highlight cutting-edge security solutions introduced in the past year that deliver significant opportunities and benefits to owners, managers, salespeople and technicians of installing security providers.
"The recognition from Security Sales & Integration demonstrates our commitment to the market as an industry innovator," said Jon Siann, Founder and CEO, MicroPower Technologies. "We are focused on providing enterprise-class technologies to our integration partners that meet the needs of the most complex perimeter surveillance environments."
About MicroPower Technologies Inc.
MicroPower Technologies develops wireless, solar-powered surveillance solutions that are cost effective, easy-to-deploy, secure and highly reliable. The company's extremely scalable, enterprise-class video security technologies redefine the use of surveillance in outdoor and perimeter applications through the use of intelligent algorithms that enhance video transmission and bandwidth, and reduce power. The MicroPower camera system eliminates data and power cables as no wires are required for video transmission or power. MicroPower products are distributed globally in the commercial, border protection, government, retail, education, parking and public utility markets. For more information, visit www.micropower.com.


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Exchange opportunities at Unibo
Through participation in the Erasmus+ and Erasmus Mundus programmes, international networks and projects and agreements with prestigious foreign universities, students, researchers and technical and administrative staff can take part in exchanges at the University of Bologna.
- Erasmus+ and other exchange programmes
- If you want to add an international dimension to your educational path by spending a study period abroad, the University of Bologna is pleased to welcome you. The University of Bologna takes part in many exchange programmes giving students from all over the world the opportunity to follow part of their educational programme at the University of Bologna.
- Erasmus Mundus Action 2 Projects
- General information on the programme and project run since 2007.
- The Science without Borders
- Science without Borders - CSF Italy is a special project aimed at fostering International mobility of the Brazilian students and researchers in highly qualified academic and research centers around the World through a scholarship scheme and at attracting young investigators and internationally recognized research leaders to Brazil.
- Incoming Staff Training Service
- The University of Bologna offers technical and administrative staff from European Universities (with which a bilateral agreement is in place) the opportunity to carry out a period of staff training in its facilities.
- Opportunities for international teaching and research staff
- The University of Bologna offers a range of opportunities for international teaching and research staff.
Find out more
See also
- Course unit catalogue Published
- Times and classrooms Published
- The ECTS grading scale and tables Published
- Fulbright Anniversary in Europe Award - Migration Studies Published


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At Gemvara, we believe that the jewelry you wear should be as unique as you. Every beautiful Gemvara rose gold tourmaline geometric jewelry design will be made just for you. It's jewelry for all life's occasions, from an anniversary or engagement to your own personal milestones and celebrations. Celebrate this Christmas with a personalized piece of jewelry that shows how much you care. Gemvara uses only the highest quality materials to craft your rose gold tourmaline geometric jewelry with meticulous attention to detail. Our precious metals are recycled or responsibly mined. The gem of creativity and innovation, tourmaline has the power to inspire artistic expression. Available in a rich palette, there is a tourmaline for every jewelry design. Gemvara offers tourmaline in a warm pink and a lush green. Tourmaline is an October birthstone and the 8th anniversary gem. The most popular rose gold alloy, 14-karat rose gold is 58.5% pure gold with copper added for color. Its rosy glow flatters skin tones. Our wide selection of rose gold tourmaline geometric jewelry by Damon Washington, Just Like You Designs, David West, and other talented designers means you can find rings, earrings, and necklaces that are exactly your style. You can also shop by style, choosing our Featured Set, Contemporary, or Geometric Collections. When our work is done and you open that box, you'll see your design is even more beautiful when brought to life in the finest precious materials.
We can help right away. Chat with a jewelry expert now!


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Beguiling Alligator Toy
To make this toy, you will need: 5 strips of green construction paper, glue, 1 spring-type clothespin, and 2 tiny beads or craft-store eyes.
Make chain with paper strips.
Clamp clothespin on one end of chain.
Glue bead-eyes on clothespin.
Orange-Peanut Spread
1/4 cup peanut butter
1/4 cup frozen orange juice concentrate, thawed
Gradually stir orange juice into peanut butter. When smooth, spread on raisin bread.
The Beguiling Alligator
"Won't you come along with me?"
said the alligator fellow
As he waddled from the marshy pond,
looking sleek and mellow.
"We'll have a merry party—
it will be a jolly ball.
We'll dance a swinging hula,
and I'll welcome one and all.
We'll dine on watermelon
and finish off with cake.
Then, when we feel like swimming,
why, there's my private lake!
"Come, ye turtles, fowls, all critters.
Come, ye everyone.
Join the merry party.
We'll have a lot of fun!"
So they hurried to the party,
where he dined them splendidly
With cake and ice-cream sundaes,
all served most festively.
And when they all were filled right up
with hot dogs and more cake,
He very kindly led them
to his own secluded lake.
They tumbled in the water
(the foolish and the fat!),
And the alligator ate them!
And that, my friend, is that!


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A Phase 2 Study to Evaluate the Dose and Pharmacodynamic Efficacy of Sialic Acid-Extended Release (SA-ER) Tablets in Patients With GNE Myopathy or Hereditary Inclusion Body Myopathy (GNE Myopathy)
This study has been completed.
Ultragenyx Pharmaceutical Inc
Information provided by (Responsible Party):
Ultragenyx Pharmaceutical Inc
ClinicalTrials.gov Identifier:
First received: January 17, 2012
Last updated: June 14, 2016
Last verified: June 2016
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
GNE myopathy or hereditary inclusion body myopathy (HIBM) is a severe progressive metabolic myopathy caused by a defect in the biosynthetic pathway for sialic acid (SA).
|GNE Myopathy Hereditary Inclusion Body Myopathy
|Drug: Sialic Acid Extended Release (SA-ER) Drug: Placebo
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Dose and Pharmacodynamic Efficacy of Sialic Acid-Extended Release (SA-ER) Tablets in Patients With GNE Myopathy or Hereditary Inclusion Body Myopathy
Resource links provided by NLM:
Genetics Home Reference related topics: CAV3-related distal myopathy Laing distal myopathy distal myopathy 2 inclusion body myopathy 2
MedlinePlus related topics: Muscle Disorders
Genetic and Rare Diseases Information Center resources: Inclusion Body Myopathy 2 Muscular DystrophyU.S. FDA Resources
Further study details as provided by Ultragenyx Pharmaceutical Inc:
Primary Outcome Measures:
- Evaluate the effect of SA-ER treatment on muscle sialylation, strength, and function in patients with HIBM. [ Time Frame: Baseline, Week 24, and Week 48 ]To evaluate the effect of SA-ER treatment on improvement of biochemical measures of sialylation and pathology in muscle. On mobility, strength, and function using a series of quantitative and physical performance measures and quality of life using patient-reported outcome measures.
|Study Start Date:
|May 2012
|Study Completion Date:
|November 2013
|Primary Completion Date:
|November 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: 6,000 mg SA-ER
Subjects will receive this dose for the duration of the study (total study duration of 48 weeks).
Drug: Sialic Acid Extended Release (SA-ER)
SA-ER will be administered in doses of 3000mg per day or 6000mg per day
Placebo Comparator: Placebo
Subjects will be randomized to the placebo arm for the first 24 weeks of the study. Then, subjects in this arm will be re-randomized into either the 3,000 mg per day or 6,000 mg per day arm for the remaining 24 weeks of the study (48 weeks total study duration).
Drug: Placebo
Subjects will be randomized to the placebo arm for the first 24 weeks of the study. Then, subjects in this arm will be re-randomized into either the 3,000 mg per day or 6,000 mg per day arm for the remaining 24 weeks of the study (total study duration 48 weeks).
Experimental: 3,000 mg SA-ER
Subjects will receive this dose for the duration of the study (total study duration of 48 weeks).
Drug: Sialic Acid Extended Release (SA-ER)
SA-ER will be administered in doses of 3000mg per day or 6000mg per day
Detailed Description:
GNE myopathy or hereditary inclusion body myopathy (HIBM) is a severe progressive metabolic myopathy caused by a defect in the biosynthetic pathway for sialic acid (SA). Substrate replacement therapy is a potential therapeutic strategy based on the success of replacing missing SA and reducing muscle disease in a relevant mouse model of the human disease (Malicdan et al., 2009). Successful use of SA replacement therapy in humans is believed to depend upon providing steady long-term exposure to the compound in an extended release form (such as Sialic Acid-Extended Release [SA-ER]), given SA's short half-life. Following a Phase 1 study to establish the pharmacokinetics (PK) for SA-ER, Ultragenyx is conducting this study to assess the dose and potential pharmacodynamic effect of restoring sialylation of muscle by treatment with SA-ER at two dose levels as compared to placebo when administered over two 24 week periods of time. The study will also evaluate safety, as well as the effect of SA-ER on clinical measures of muscle strength, mobility, function and self-reported disability and quality of life. Effects on muscle volume/mass and function and on serum biomarkers will be evaluated as exploratory measures. These data should allow the selection of a dose and the appropriate design for a Phase 3 clinical study.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Must be between 18 and 65 years of age, inclusive.
- Must be willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures.
- Must have a documented diagnosis of GNE myopathy, HIBM, distal myopathy with rimmed vacuoles (DMRV), or Nonaka disease due to previously demonstrated mutations in the gene encoding the GNE/MNK enzyme. Genotyping will not be conducted in this protocol.
- Must be able to walk 20 meters independently (may use orthotics and assistive devices).
- Must be able to provide reproducible force in bilateral elbow flexors and knee extensors during hand-held dynamometry testing (unilateral between test variability of < 15% for both muscle groups).
- Must be willing and able to comply with all study procedures including fine needle muscle biopsies of the upper (e.g., triceps brachii or posterior deltoid) and lower (e.g., biceps femoris or vastus lateralis) extremities at Baseline and 24 and 48 weeks.
- Sexually active subjects must be willing to use an acceptable method of contraception while participating in the study.
- Females of childbearing potential must have a negative pregnancy test at Screening and be willing to have additional pregnancy tests during the study. Females considered not of childbearing potential include those who have been in menopause for at least two years, or have had tubal ligation at least one year prior to Screening, or who have had total hysterectomy.
Exclusion Criteria:
- Pregnant or breastfeeding at Screening or planning to become pregnant (self or partner) at any time during the study.
- Use of any investigational product or investigational medical device within 30 days prior to Screening, or requirement for any investigational agent prior to completion of all scheduled study assessments.
- Ingestion of N-acetyl-D-mannosamine (ManNAc), SA, or related metabolites; intravenous immune globulin (IVIG); or anything that can be metabolized to produce SA in the body for the prior 60 days.
- Has a condition of such severity and acuity, in the opinion of the investigator, that it warrants immediate surgical intervention or other treatment or may not allow safe participation in the study.
- Has had any hypersensitivity to SA or its excipients that, in the judgment of the investigator, places the subject at increased risk for adverse effects.
- Has a concurrent disease or condition that, in the view of the principal investigator, places the subject at high risk of poor treatment compliance or of not completing the study, or would interfere with study participation or would affect safety.
- Has serum transaminase (i.e., alanine aminotransferase [ALT], aspartate aminotransferase [AST], or gamma-glutamyl transpeptidase [GGT]) levels greater than three times the upper limit of normal or serum creatinine of greater than 2.0 mg/dL.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01517880
Please refer to this study by its ClinicalTrials.gov identifier: NCT01517880
|United States, California
|UCLA Medical Center
|Los Angeles, California, United States, 90095
|United States, Missouri
|Washington University School of Medicine
|St. Louis, Missouri, United States, 63110
|United States, New York
|New York University School of Medicine
|New York, New York, United States, 10016
|Hadassah University Hospital
|Jerusalem, Israel, 91120
Sponsors and Collaborators
Ultragenyx Pharmaceutical Inc
|Principal Investigator:
|Alan Pestronk, MD
|Washington University School of Medicine
|Principal Investigator:
|Perry Shieh, MD
|University of California, Los Angeles
|Principal Investigator:
|Yoseph Caraco, MD
|Hadassah University Hospital
|Principal Investigator:
|Heather Lau, MD
|New York University School of Medicine
More Information
Keywords provided by Ultragenyx Pharmaceutical Inc:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 20, 2017
|Responsible Party:
|Ultragenyx Pharmaceutical Inc
|ClinicalTrials.gov Identifier:
|NCT01517880 History of Changes
|Other Study ID Numbers:
|Study First Received:
|January 17, 2012
|Last Updated:
|June 14, 2016
Keywords provided by Ultragenyx Pharmaceutical Inc:
Hereditary Inclusion Body Myopathy (HIBM)
GNE myopathies
distal myopathy with rimmed vacuoles [DMRV]
Nonaka disease
Additional relevant MeSH terms:
Muscular Diseases
Distal Myopathies
Musculoskeletal Diseases
Neuromuscular Diseases
Nervous System Diseases
Muscular Dystrophies
Muscular Disorders, Atrophic
Genetic Diseases, Inborn
ClinicalTrials.gov processed this record on September 20, 2017


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DICE returns with the latest in the acclaimed Battlefield series of first person shooters. One of the biggest releases of 2011, the game will provide thrills for all, no matter how they choose to play. For those who prefer to stand alone, the single player campaign takes place on the Iran/Iraq border as the US Marines face insurgents from all sides. An online co-op mode is also included for those who prefer a score-attack.The main thrust with Battlefield 3 is, as always, the multiplayer. With players taking on one of four roles, some offensive, some defensive. The range of options available will include the usual formats expected from a high quality, from team and squad deathmatches to last man standing bulletstorms. Players will also be able to use the brand new Battlelog social system to co-ordinate games.DICE aims to provide the most realistic environments in a game ever through the use of their new Frostbite 2 engine. With more advanced destruction modelling than any previous game in the series, everything is a potential target and gamers will happily take it all down. Characters also look more realistic than ever before thanks to the introduction of ANT technology and everything comes together to provide a truly "real" world.With high quality graphics, sound and gameplay coming together, EA and DICE are hoping that when it comes to the Battle for Gamers, victory will fall on their side.
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It seems like nothing can keep Sarah Silverman down.
Over a year after Comedy Central canceled "The Sarah Silverman Program," Silverman has just picked a pilot commitment for her new sitcom, which is currently untitled. According to Deadline, the premise for the series is loosely based on Silverman's life and would follow her as she portrays "a woman readjusting to the single life after a decade-long live-in relationship." Silverman will write the script with Dan Sterling and Jon Schroeder, who previously worked with Silverman on her Comedy Central series.
NBC picked up the script back in August after a fierce bidding war. Ron Howard's Imagine TV and 20th Century Fox TV are producing the series, with Howard, Brian Grazer and Francie Calfo also on board as executive producers.
Since the end of her Comedy Central series, Silverman has made guest turns on "The Good Wife," "The League" and "Bored To Death." Prior to that, she had well received appearances on "Monk," "Mr. Show," "Seinfeld" and "Entourage." Silverman also starred in the controversial stand-up comedy concert film, "Jesus is Magic." Additionally, Silverman won an Emmy Award for her parody song, "I'm F**king Matt Damon," which debuted on "Jimmy Kimmel Live."
It has also been noted that Silverman's brand of comedy is similar to that of Whitney Cummings and Chelsea Handler; which suggests that the network could have a female driven comedy block on its hands next fall if both "Whitney" and "Are You There, Chelsea?" are renewed by NBC.
Who should be cast alongside Silverman in her new NBC pilot? Share your picks in the comment section below!


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The Solution Accelerators Team is offering customers and partners added inventory and assessment capabilities with the Microsoft Assessment and Planning (MAP) Toolkit 5.0 Community Technical Preview (CTP). The MAP Toolkit 5.0 CTP provides customers and partners with new features such as inventory of heterogeneous server environments; the ability to determine usage of deployed System Center Configuration Manager (a member of the Core Client Access License Suite); and readiness assessment for migration to Office 2010. Over 800,000 Microsoft customers and partners including Costco Wholesale Corporation, Continental Airlines, and Pella Corporation have already downloaded and used this toolkit to help plan for their server and client deployments.
Toolkit Features— What's New with version 5.0 CTP?
The Microsoft Assessment and Planning Toolkit 5.0 CTP includes the following new features:
• Heterogeneous Server Environment Inventory for Technologies including Windows Server, Linux, UNIX and VMware.
• Ability to determine usage of deployed System Center Configuration Manager, a member of the Core Client Access License Suite.
• Office 2010 Readiness Assessment.
Additional Features
• Windows 7 Hardware and Device Compatibility Assessment.
• Windows Server 2008 R2 Hardware and Device Compatibility Assessment.
• Virtualization Candidates Assessment for Hyper-V Server Consolidation.
• Inventory of VMware Server Hosts and Guests.
• User Interface and Proposal Customization for Partner co-branding.
• Enhanced Usability and Improved Inventory Performance.
• SQL Server Instance Discovery.
• Desktop Security Assessment for Anti-virus and Anti-malware Programs Installation.
• Forefront Client Security/NAP Readiness Assessment.
Benefits to Customers and Partners
Saves Planning or Pre-Sales Time. A detailed network inventory and assessment of servers and desktops often takes days of manual labor. With Microsoft Assessment and Planning Toolkit, you can now conduct an environment inventory of up to 100,000 computers in a matter of hours instead of days, giving you extra time to focus on critical planning or pre-sales tasks and information necessary to make the business case for client, server, and virtualization projects.
Provides Actionable Recommendations and Reporting. The MAP Toolkit provides valuable inventory and readiness assessment reports with environment-specific reports, making it easier for IT migration and deployment projects to get off the ground and running.
Covers Wide Range of Scenarios—from Desktops to Servers. The MAP Toolkit offers technology assessments and planning recommendations for many Microsoft desktop and server products including Windows 7, Windows Server 2008 R2, Hyper-V R2, Windows Vista, Windows Server 2008, Hyper-V, Virtual Server 2005 R2, 2007 Microsoft Office, SQL Server 2008, Forefront Client Security, Network Access Protection, and more.
MAP 5.0 CTP is available on Connect.


text:
Collective efficiency strategies: a policy instrument for the competitiveness of low-density territories
This paper motivates the focus of EU cohesion policy at large and the territorial cooperation tools on the economic development of territories featuring impoverishing growth associated to low population density. An innovative policy approach to help solving this problem in many Member States is put forward here. It is based on the economic concept of "collective efficiency". It should be understood as a proposal to improve EU cohesion policy in the next programming period. As such, the paper suggests actual ideas to be included in the forthcoming Common Strategic Framework and Development and Investment Partnership Contracts.
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|Date of creation:
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| Postal: Núcleo de Investigação em Políticas Económicas, Escola de Economia e Gestão, Universidade do Minho, P-4710-057 Braga, Portugal
Phone: +351-253604510 ext 5532
Fax: +351-253601380
Web page: http://www3.eeg.uminho.pt/economia/nipe/versao_inglesa/index_uk.htm
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text:
Rosenberg: Ignore Whitney, Buy the Heck out of Muni Bonds
From Pragmatic Capitalism:
"There is a clear buyers' strike in the market for state and local government debt that is largely based on fear and misperception. The mass selling of muni's, which represent the bedrock of the U.S. economy, is incredible ― nine consecutive weeks of net redemptions totalling $16.5 billion ($1.5 billion in the January 15 week). Talk about fertile ground for a huge long-term buying opportunity.
First, even if you buy into the default talk, look at the yield protection you get now. There are some long-term muni's trading north of eight percent ― even higher than junk bonds (a premium of over 100bps!). Long-term AAA-rated muni's are now trading well north of five percent or 116% vis-a-vis Treasury bonds (typically, muni bond yields are equivalent to 82% of Treasury yields given their tax advantage). California off-the-run 30-year 6% bonds are now being quoted at a yield premium to dollar-denominated debts offered by the likes of Mexico and Columbia.
Give me a giant break.
Even in California, only teachers come in front of bond holders. In other states, the debt holders are the first to get paid. It's amazing how few people know that.Read more here.


text: Just curious as to what people's charging patterns are. Do you: -Charge it when it reaches a certain percentage (I.e. 20, etc)? -Put it back on your dock or plug it in whenever you're not using it? -Let it die completely? Is there an advantage or disadvantage (in your empirical opinion) to whichever method you use?


text:
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Dogs: Homoeopathic RemediesEbury Publishing 2012; US$ 18.32
This book is written to satisfy the needs of the increasing numbers of dog lovers who are interested in alternative methods to treat their pets. This comprehensive guide introduces the principles of homoeopathy and the nature of homoeopathic remedies, explaining how remedies can be prepared and administered. There are informative sections on treating... more...
The Treatment Of Horses By HomoeopathyEbury Publishing 2011; US$ 23.96
This book is for anyone who is interested in the welfare of horses, and who wishes to know more about treating them with homoeopathic remedies. Increasing numbers of horse owners and handlers today confirm that homoeopathy is a speedy and effective treatment, which can often deal with so-called 'incurable' ailments. As this fascinating guide explains,... more...
Cats: Homoeopathic RemediesEbury Publishing 2011; US$ 18.32
This book is written to satisfy the needs of the increasing numbers of cat lovers who are interested in alternative methods to treat the illnesses to which their pets may fall prey. This comprehensive guide introduces the principles of homoeopathy and the nature of homoeopathic remedies, explaining how remedies can be prepared and administered. There... more...
The Treatment Of Cattle By HomoeopathyEbury Publishing 2012; US$ 21.14
Many farmers today are concerned, not only with the increasing cost of conventional drugs, but also with their side-effects and the build-up of resistant strains of bacteria due to the continued and often indiscriminate use of antibiotics. While this book will appeal to the already converted it is hoped that the unprejudiced newcomer will be sufficiently... more...
PigsEbury Publishing 2012; US$ 21.14
Written in response to a growing demand on the part of pig farmers, here is a text-book which will provide a working manual to which reference can be readily made. Not all the diseases discussed in the text are of interest to pig producers in the United Kingdom but they have been included in the hope that they may be of interest to pig farmers in... more...
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text:
The Rain took a toll on the softball and baseball sectional tournament Friday. A majority of the days semifinal games have been pushed back.
Softball semifinals will now be played Saturday, May 25th at the same time and loactions they were originally schedule for.
All the baseball semifinals will be played on the 28th. Class AA will be played at 4pm and 7pm at Joe Bruno Stadium. Class A will take place at Saint Rose at 4pm and 7pm. Class C will take place in Amsterdam at Shuttleworth Park at 4pm and 7pm. Class D will take place in Glens Falls at 1pm and 4pm.
The Class B seimis will take place at Veterans Park in Saratoga at 1pm and 4pm.


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CAR parks in Castle Point appear to have been abandoned after the council introduced parking charges.
A number of residents said they were frustrated at the charges and waiting restrictions, especially Oak Road car park, Canvey, after it continued to flood in heavy rain.
Charges were introduced on February 1 at Oak Road as well as Richmond Hall, Benfleet, and Lubbins car park, on Canvey seafront.
Since then, the usually busy car parks appear to have been quiet as people park free elsewhere.
George Whatley, 72, of Limburg Road, Canvey, said: "All the while people are told to pay for a car park which is only half usable because of flooding, then why on earth would they use it?
"It is totally wrong and of course people will look elsewhere if they can save some money."
Disgruntled residents took to Facebook to vent their frustration at the condition of the paidfor car parks.
Tara Newman said: "It's in such a poor state – don't use it.
"They will soon take away the pay and display, unlessamiracle happens and they sort the puddle out."
Meanwhile, others have joked a "boats for hire" service should be introduced.
A £240,000 refurbishment of the car parks will begin in spring to improve the condition of the council's parking facilities.
Residents can still park free at car parks in Hart Road, Thundersley; Homestead, Hadleigh; Richmond Avenue, Benfleet; Castle Lane, Hadleigh and Thorney Bay, Canvey.
Colin Riley, Conservative councillor responsible for the environment and street scene, said he was not aware of a drop in the number of people parking.
He said: "We will review the situation at each car park, but it is far too early to do that at the moment.
"After three to six months we will be in a better position to act, if we need to. We'll see what happens.
"Oak Road is the first one that will be repaired. We have commisioned a drainage survey as there is a problem every time we get a deluge of rain.
"This is being carried out as we speak and we are already pumping the car park twice a week.
"However, we can't begin excavation works until the survey is concluded.
"I expect to see things progress over the next couple of weeks and the work may be done in two months."


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A pub which, with its customers rears pigs, and doubles up as a local shop has scooped a top award from Aylesbury Vale District Council.
The Unicorn in Cublington has been named the overall winner of the council's annual village pub competition, sponsored by Dayla.
It's a huge turn around for the 17th century inn which was previously threatened with closure but is now thriving under the ownership of two villagers.
Councillor Pam Pearce, cabinet member for community matters, said: "This is the 15th year we have run this competition and we have seen some excellent pubs, but the Unicorn has set a new standard. It's a true example of what can be achieved with hard work, especially given the current economic climate."
As well as offering a wide range of real ales, outstanding food (the pub has two AA rosettes) and a variety of top entertainment, the Unicorn supplies freshly baked bread and milk to villagers by running an on-site shop. It also heads up a syndicate which owns Cublington pigs, where villagers jointly rear the animals.
Manager Tim Harwood said: "We're thrilled to have won this award. I guess our secret is team work, top quality food and support from the community."
Tim Cooper, managing director of Dayla, said: "At a time when pubs are closing across the UK, it is really great to see so many flourishing."
Aylesbury Vale District Council received more than 700 nominations for 35 pubs – the highest number of entries since the contest started in 1997. The nominees were whittled down to 20 finalists by the judging panel, which considered, among other things, how pubs supported their local community and attracted tourists.
Winners were selected in six categories:
> Best overall pub: The Unicorn, Cublington
> Runner-up overall pub: The Old Thatched Inn, Adstock
> Best community pub: The Bell, Chearsley
> Runner-up community pub: The Red Lion, Bierton
> Best food pub: The Old Thatched Inn, Adstock
> Runner-up best food pub: The Chequers Inn, Weston Turville
> Best speciality food: The Swan, Grendon Underwood
> Best website: The Old Thatched Inn, Adstock
> Best website runner up: The Pheasant Inn, Brill
> One to watch: The Boot, Soulbury, The Seven Stars, Dinton, and The Pilgrim Pub and Restaurant, North Marston.


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Thanks to its location and architectural design this terraced house is perfectly integrated in the town of San Antonio de Benageber. Its entry gives us an idea of the peace and security that we can find in the area. We access into the house through a little garden and when we up a few steps we find a friendly terrace accommodated with a large table. The entry is through a hall and we have a large living dining room with fireplace, on this floor also there is a bathroom and a big kitchen with office and laundry annex. From the kitchen we can go to the back courtyard equipped with a barbecue. On the second floor we have the sleeping area, consisting of a main bedroom with dressing room and suite bathroom, , three further bedrooms and a bathroom. All rooms are spacious and bright. The house also has on its top floor an attic. On the lower ground floor, we access from the back courtyard and the street, we have a large garage for more than two cars and storage. The whole house has windows with double glazing and gas central heating.
The house is located between L'Eliana and San Antonio de Benageber, perfectly integrated in this last town. The access to the CV-35 is fantastic, the area is near to the city of Valencia ( 17km) and the airport ( 10km) . It is a quiet area near to the town allowing us access to the services offered by this community, health center , sports center , swim pool, schools , shopping center " El Osito" , golf club Scorpion , ...
Availability upon agreement. The offer is subject to change of price or withdrawal without previous notice. The exposed dada including the dimensions are merely illustrative. In order to confirm the dimensions and juridical circumstances of the sales and purchase deal the Agency recommends to consult an independent competent professional.
The price does not include the taxes and costs. Corresponds to the purchaser the payment of the following taxes and costs: (i) in a first deliveries of residences (new residences) the Value Added Tax and the Tax on Documented Legal Actions; (ii) in a second and subsequent deliveries of residences (used residences) the Property Transfer Tax; (iii) notary and registry tariff; (iv) the Agency's fees. For the rest of the information demanded by state and autonomous government regulations, please get in touch with the Agency.


text:
Have you seen these Wet Bags from Bumkins?
They are SO cute! And better yet, they're just crazy useful. They zip shut, weigh practically nothing, and are machine-washable.
Here's a few ways I love to use them:
- Wet swimsuits. Nothing worse than soaking the seat of your car with a wet swimsuit. Advertisement
- A yucky diaper when no garbage is around. Sometimes you get stuck somewhere that has no garbage cans, but you want to keep it from leaking all over everything else while you get it home.
- Clothing that's been spit-up on. Those babies! They just don't know to stop throwing up their little lunches.
- Used wipes. Ever grabbed a wipe to clean off a messy face or hands and then had nowhere to stick them? No more!
- Filthy shoes. Little ones seem to know just where those muddiest spots are. And you don't want those shoes all over the carseat or stroller.


text:
A LUCKY customer won £10,000 on a scratchcard at a petrol station in Harborough.
The customer scooped the money after buying the card from the Tesco Express petrol station in Rockingham Road.
It happened on October 20.
At the same store last month another customer won £500, also on a scratchcard.
The £500 winner told the Mail he will be spending the cash on a new laptop.
Paul Clifton, deputy manager of the Tesco outlet, said: "We're really pleased that we were a lucky store for our customers."


text:
Etsy Find: House and Linen Spray
If you don't have time to whip up some homemade deodorizer for your home, I bet you have time to order a bottle on Etsy, right? These room and linen sprays ($6.95 for a 4.75-ounce bottle), from WendyLousNaturalBath, can be made in a number of different scents. I'd order a couple and find out what scent works best for your home. Made with natural ingredients, no alcohol, and minimal preservatives, this is a natural home scent you can feel good about.


text:
Boundless is a club dedicated to those in the Civil Service and Public Sector looking to get the most out of their free time.
Join Boundless to enjoy:
- £100 worth of exclusive member vouchers for you†
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- An award-winning magazine packed with offers, inspiration and reviews
All Boundless profits go straight back into the club so we can give more back to you.
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Get great value and first class service from brands you know and love.
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Boundless offers its members hundreds of fantastic experiences, volunteer activities and things to do to help you get the most out of your free time.
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We are here for those who love getting out and enjoying life, sharing good times, collecting memories and getting a good deal along the way. Join Boundless today and discover our amazing local and interest groups.
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Membership gives me access to lots of great features and keeps me up to date with like-minded people.
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* Terms and conditions apply. Visit boundless.co.uk/winacar
† Vouchers available for new members only. LV= Vouchers redeemable for members first year of cover only, not renewal. Applicable for LV= car insurance, LV= Britannia Rescue breakdown cover and LV= home insurance.
1 £50 off your first stay is redeemable by new members only and is valid at all Boundless-owned UK Breaks (excluding pitches) Ghyll Manor Hotel & Restaurant only for a two night stay including dinner, bed and breakfast. Redeemable by new members only. Terms and conditions apply..
2 Based on normal price including IPT to add MLE to an LV= car insurance policy. The use of MLE is not limited to LV= policies. You do not need to apply for this cover, it is provided automatically from the day you join Boundless.


text:
Jaime Casanova wrote: > Hi, > > i'm willing to review something else while we have time for that... is > there any patch out there that need some additional help? > We still don't have anyone looking at the XLogInsert patch. If you could check that out, that would be great. -- Greg Smith 2ndQuadrant Baltimore, MD PostgreSQL Training, Services and Support greg(at)2ndQuadrant(dot)com www.2ndQuadrant.com
Next: From: Jeff Davis Date: 2009-12-10 02:25:59 Subject: Re: Review request: XLogInsert Previous: From: Jaime Casanova Date: 2009-12-08 21:25:12 Subject: there's any free patches?