text:
SDX-105 in Combination With Rituxan for Patients With Relapsed Indolent or Mantle Cell Non-Hodgkin's Lymphoma (NHL)
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This is an open label study combining Rituxan and SDX-105. Rituxan will be given on day 1 followed by a 30-60 minute intravenous infusion of SDX-105 on day 2 and day 3. Treatment will repeat every 21 days (a cycle). Treatment can continue for up to 6 cycles (about 4 months) if tumor status improves and there are no unacceptable side effects. Patients will be followed for up to 2 years or until disease progression.
Rituxan has been shown to increase the sensitivity of cells to chemotherapy. The combination of SDX-105 and Rituxan has been effective in both the laboratory and in a recent clinical study with Non-Hodgkin's lymphoma patients.
This study will evaluate the safety and effectiveness of SDX-105 plus Rituxan in patients with Non-Hodgkin's lymphoma who have relapsed after taking Rituxan.
|Non-Hodgkin's Lymphoma
|Drug: bendamustine and rituximab
|Phase 2
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Multi-Center Phase II Study to Investigate the Safety and Activity of SDX-105 (Bendamustine) in Combination With Rituximab in Patients With Relapsed Indolent or Mantle Cell Non-Hodgkin's Lymphoma (NHL)
- Determine the objective response rate (ORR = CR + PR) to a regimen of SDX-105 plus rituximab in patients with relapsed indolent or mantle cell non-Hodgkin's lymphoma [ Time Frame: 4-6 months ]
- • To characterize the safety profile of SDX-105 plus rituximab in this patient population • To determine the one-year and Kaplan-Meier estimates of progression-free survival (PFS) rates • To determine the median duration of response (DR) [ Time Frame: 4-6 months ]
|Study Start Date:
|April 2004
|Study Completion Date:
|March 2008
|Primary Completion Date:
|December 2005 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: 1
open-label, single arm, clinical trial of bendamustine (SDX-105) plus rituximab
Drug: bendamustine and rituximab
Patients will receive rituximab on the first day of a cycle at a dose of 375 mg/m2, followed on the second and third day of a cycle by SDX-105 (bendamustine) at a dose of 90 mg/m2/day of treatment. Four cycles are planned. Patients will receive a dose of rituximab alone 7 days prior to the first cycle of the combination and a dose of rituximab 28 days after the last cycle of the combination. If there is documented disease regression, a fifth and sixth cycle of SDX-105 plus rituximab may be administered.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Documented B-Cell NHL or mantle cell lymphoma
- CD-20+ tumor
- Indolent NHL: follicular B-cell lymphoma, diffuse small lymphoma, marginal zone lymphoma
- Maximum of three prior chemotherapy regimens
- Age of at least 18 years at Screening Visit (Site specific requirement may differ)
- Refractory to rituximab, defined as progression of disease while being treated with rituximab or progression within 6 months of the last dose of rituximab (when given either as a single agent or in combination)
- Previous chemotherapy or immunotherapy within 3 weeks prior to entering the study (6 weeks for nitrosoureas or mitomycin) or failure to recover from adverse events due to any agents administered previously
- Use of investigational agents within 28 days of study
- History of prior high dose chemotherapy with allogeneic stem cell support
- History of prior radioimmunotherapy
Please refer to this study by its ClinicalTrials.gov identifier: NCT00076349
Show 34 Study Locations
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT00076349 History of Changes
|Other Study ID Numbers:
|Study First Received:
|January 20, 2004
|Last Updated:
|May 8, 2014
Keywords provided by Teva Pharmaceutical Industries ( Cephalon ):
Non-Hodgkin's Lymphoma
Mantle Cell
Additional relevant MeSH terms:
Lymphoma, Non-Hodgkin
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Bendamustine Hydrochloride
Antineoplastic Agents
Immunologic Factors
Physiological Effects of Drugs
Antirheumatic Agents
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 19, 2017


text:
Research Topics
Genomes and Genes
rana catesbeiana
Summary: A species of the family Ranidae (true frogs). The only anuran properly referred to by the common name "bullfrog", it is the largest native anuran in North America.
Articles from Journal RESEARCH
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Articles from Journal RESEARCH1
Publications239 found, 100 shown here
- The emerging amphibian pathogen Batrachochytrium dendrobatidis globally infects introduced populations of the North American bullfrog, Rana catesbeianaTrenton W J Garner
Institute of Zoology, Zoological Society of London, Regent s Park, London NW1 4RY, UK
Biol Lett 2:455-9. 2006..Here, we show that introduced North American bullfrogs (Rana catesbeiana) consistently carry this emerging pathogenic fungus...
- Nerve conduction block utilising high-frequency alternating currentK L Kilgore
MetroHealth Medical Center, Cleveland, Ohio, USA
Med Biol Eng Comput 42:394-406. 2004..The results of this study demonstrated that high-frequency AC can be used to produce a fast-acting, and quickly reversible nerve conduction block that may have multiple applications in the treatment of unwanted neural activity...
- Caspase activation in response to cytotoxic Rana catesbeiana ribonuclease in MCF-7 cellsC C Hu
Institute of Biology and Anatomy, National Defense Medical Center, 161, Sec. 6, MinChuan E. Rd, 114, Taipei, Taiwan
FEBS Lett 503:65-8. 2001b>Rana catesbeiana ribonuclease (RC-RNase) and onconase were proven to own anti-tumor activity...
- Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active processP Martin
Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA
Proc Natl Acad Sci U S A 98:14380-5. 2001..This behavior, which is not generic for active oscillators, can be accommodated by a simple model that characterizes quantitatively the fluctuations of the spontaneous movements as well as the hair bundle's linear response function...
- D2 Dopamine receptor subtype mediates the inhibitory effect of dopamine on TRH-induced prolactin release from the bullfrog pituitaryMasaki Nakano
Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama 338 8570, Japan
Gen Comp Endocrinol 168:287-92. 2010..Distal lobes of the bullfrog (Rana catesbeiana) were perifused and the amount of PRL released in the effluent medium was measured by means of a homologous ..
- Elevated maintenance costs in an anuran (Rana catesbeiana) exposed to a mixture of trace elements during the embryonic and early larval periodsC L Rowe
University of Georgia, Savannah River Ecology Laboratory, Aiken, South Carolina 29802, USA
Physiol Zool 71:27-35. 1998..maintenance costs (standard metabolic rates, measured as O2 consumption at rest) in tadpoles of the bullfrog, Rana catesbeiana, and exposure to contaminants in a coal ash-polluted habitat (characterized by a variety of trace elements)...
- Solution structure of the cytotoxic RNase 4 from oocytes of bullfrog Rana catesbeianaChun Hua Hsu
Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan, ROC
J Mol Biol 326:1189-201. 2003..residues linked with four disulfide bridges, is a cytotoxic ribonuclease isolated from oocytes of bullfrog Rana catesbeiana. RNase 4 belongs to the bovine pancreatic ribonuclease (RNase A) superfamily...
- Differential regulation of ER Ca2+ uptake and release rates accounts for multiple modes of Ca2+-induced Ca2+ releaseMeredith A Albrecht
Department of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
J Gen Physiol 119:211-33. 2002....
- Plasma catecholamines with hemorrhage in the bullfrog, Rana catesbeianaS Hillman
Department of Biology, Portland State University, Oregon 97207, USA
J Exp Zool 280:174-81. 1998The concentrations of plasma epinephrine (E) and norepinephrin (N) measured at rest in bullfrogs (Rana catesbeiana) were 12.0 and 8.2 nmol liter-1 respectively: the ratio of [E]/[N] was 1.33 (+/- SE 0.35)...
- Rapid diversification of RNase A superfamily ribonucleases from the bullfrog, Rana catesbeianaH F Rosenberg
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Mol Evol 53:31-8. 2001We present sequences of five novel RNase A superfamily ribonuclease genes of the bullfrog, Rana catesbeiana. All five genes encode ribonucleases that are similar to Onconase, a cytotoxic ribonuclease isolated from oocytes of R. pipiens...
- Nitric oxide synthase and NADPH diaphorase distribution in the bullfrog (Rana catesbeiana) CNS: pathways and functional implicationsPhuong Huynh
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
Brain Behav Evol 70:145-63. 2007..Thus, nitrergic cells were ubiquitously distributed throughout the bullfrog brain and likely serve an essential regulatory function...
- Nitric oxide as a modulator of central respiratory rhythm in the isolated brainstem of the bullfrog (Rana catesbeiana)M S Hedrick
Department of Biological Sciences, California State University, Hayward 94542, USA
Comp Biochem Physiol A Mol Integr Physiol 124:243-51. 1999..neural activity were investigated using an in vitro brainstem preparation from North American bullfrogs (Rana catesbeiana)...
- Sexually dimorphic expression of steroidogenic factor 1 (SF-1) in developing gonads of the American bullfrog, Rana catesbeianaLoretta P Mayer
Department of Physiology, University of Arizona, P O Box 5051, Tucson 85724 5051, USA
Gen Comp Endocrinol 127:40-7. 2002..We have detected a putative SF-1 protein from several tissues in the American bullfrog, Rana catesbeiana, that co-migrates with mouse SF-1 on a Western blot...
- Multiple-timescale dynamics underlying spontaneous oscillations of saccular hair bundlesYuttana Roongthumskul
Department of Physics and Astronomy and California NanoSystems Institute, University of California, Los Angeles, California, USA
Biophys J 101:603-10. 2011..We use numerical modeling to explore the effects of internal parameters on the oscillatory profiles, and to reproduce the experimental modulation induced by mechanical or ionic manipulation...
- Nitric oxide changes its role as a modulator of respiratory motor activity during development in the bullfrog (Rana catesbeiana)Michael S Hedrick
Department of Biological Sciences, California State University, East Bay, Hayward, CA 94542 USA
Comp Biochem Physiol A Mol Integr Physiol 142:231-40. 2005..Isolated brainstem preparations from pre-metamorphic and late-stage post-metamorphic tadpoles (Rana catesbeiana) were used to determine the role of NO in modulating central respiratory neural activity...
- Peering into molecular mechanisms of action with frogSCOPECaren C Helbing
Department of Biochemistry and Microbiology, University of Victoria, P O Box 3055 STN CSC, Victoria, BC, Canada
Gen Comp Endocrinol 168:190-8. 2010..for the identification of biological response indicators of harmful effects on a species of wild frog (Rana catesbeiana) at a sensitive tadpole stage...
- High-resolution structure of hair-cell tip linksB Kachar
Section on Structural Cell Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 4163, USA
Proc Natl Acad Sci U S A 97:13336-41. 2000..Such behavior is incompatible with the measured elasticity of the gating spring, suggesting that the gating spring instead lies in series with the helical segment of the tip link...
- Toxicity of cadmium, endosulfan, and atrazine in adrenal steroidogenic cells of two amphibian species, Xenopus laevis and Rana catesbeianaBenoît N Goulet
Departement des Sciences Biologiques, TOXEN Research Center, Universite du Quebec a Montreal, C P 8888, Succursale Centre Ville, Montreal, Quebec, Canada, H3C 3P8
Environ Toxicol Chem 22:2106-13. 2003..corticosterone secretion and viability of adrenal cells of African clawed frog (Xenopus laevis) and bullfrog (Rana catesbeiana) were assessed in vitro using a new bioassay...
- Habituation as a mechanism of reduced aggression between neighboring territorial male bullfrogs (Rana catesbeiana)M A Bee
Division of Biological Sciences, University of Missouri Columbia, 65211 7400, USA
J Comp Psychol 115:68-82. 2001..The authors asked whether discrimination between neighbors and strangers by territorial male bullfrogs (Rana catesbeiana) could result from habituation of the aggressive response to repeated presentations of the acoustic ..
- Regulation of the respiratory central pattern generator by chloride-dependent inhibition during development in the bullfrog (Rana catesbeiana)Lise Broch
Department of Biological Sciences, California State University Hayward, Hayward, CA 94542, USA
J Exp Biol 205:1161-9. 2002Isolated brainstem preparations from larval (tadpole) and adult Rana catesbeiana were used to examine inhibitory mechanisms for developmental regulation of the respiratory central pattern generator (CPG)...
- Distribution of frequencies of spontaneous oscillations in hair cells of the bullfrog sacculusD Ramunno-Johnson
Department of Physics and Astronomy and California Nanosytems Institute University of California, Los Angeles, California 90095, USA
Biophys J 96:1159-68. 2009Under in vitro conditions, free-standing hair bundles of the bullfrog (Rana catesbeiana) sacculus have exhibited spontaneous oscillations...
- Structural characteristics of bullfrog (Rana catesbeiana) transthyretin and its cDNA--comparison of its pattern of expression during metamorphosis with that of lipocalinK Yamauchi
Department of Biology, Faculty of Science, Shizuoka University, Japan
Eur J Biochem 256:287-96. 1998..Here, we report the nucleotide sequence of the cDNA for a THBP found in plasma of bullfrog (Rana catesbeiana) tadpoles before the climax of metamorphosis...
- Micronucleus test for monitoring genotoxicity of polluted river water in Rana catesbeiana tadpolesM V M A Wirz
Laboratory of Experimental Air Pollution, School of Medicine, University of Sao Paulo USP, Av Dr Arnaldo 455, CEP 12046 903 São Paulo, SP, Brazil
Bull Environ Contam Toxicol 75:1220-7. 2005
- Distribution of GABA-like immunoreactive cell bodies in the brains of two amphibians, Rana catesbeiana and Xenopus laevisDavid M Hollis
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
Brain Behav Evol 65:127-42. 2005..We thus used immunocytochemistry to locate putative GABAergic cells in the brains of male bullfrogs (Rana catesbeiana) and South African clawed frogs (Xenopus laevis)...
- Genistein prevents thyroid hormone-dependent tail regression of Rana catesbeiana tadpoles by targetting protein kinase C and thyroid hormone receptor alphaL Ji
Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
Dev Dyn 236:777-90. 2007..soy products and tyrosine kinase inhibitor) and the PKC inhibitor (H7) prevent T(3)-induced regression of the Rana catesbeiana tadpole tail...
- Ultra high dilution of triiodothyronine modifies cellular apoptosis in Rana catesbeiana tadpole tail in vitroJ R P Guedes
Laboratory of Molecular Pathology, Department of Pathology, University of Sao Paulo School of Medicine, Av Dr Arnaldo 455, Sao Paulo, SP, Brazil
Homeopathy 100:220-7. 2011..Ultra High Dilutions (UHD) are diluted beyond the Avogadro limit with dynamization (dilution with succussion). The process of anuran amphibian metamorphosis is controlled by thyroid hormones, including the resorption of the tadpole tail...
- Cell proliferation in the forebrain and midbrain of the adult bullfrog, Rana catesbeianaAndrea Megela Simmons
Department of Psychology, Brown University, Providence, RI 02912, USA
Brain Behav Evol 71:41-53. 2008The distribution of proliferating cells in the midbrain, thalamus, and telencephalon of adult bullfrogs (Rana catesbeiana) was examined using immunohistochemistry for the thymidine analog 5-bromo-2'-deoxyuridine (BrdU) and DNA dot-..
- Correlated movement of hair bundles coupled to the otolithic membrane in the bullfrog sacculusC E Strimbu
University of California, Los Angeles Department of Physics and Astronomy, Los Angeles, CA 90095, USA
Hear Res 256:58-63. 2009..We imaged significant portions of the saccular epithelium, up to 40 x 350 microm(2), and observed a high degree of correlation over those scales...
- Effect of low dose exposure to the herbicide atrazine and its metabolite on cytochrome P450 aromatase and steroidogenic factor-1 mRNA levels in the brain of premetamorphic bullfrog tadpoles (Rana catesbeiana)Mark P Gunderson
Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
Aquat Toxicol 102:31-8. 2011..In the present study, we cloned and characterized partial sequences for bullfrog (Rana catesbeiana) SF-1 and CYP19 and examined the effects of a 48h exposure to 1 and 100μg/l of the herbicide atrazine (ATZ) ..
- Characterization of plasma triiodophenol binding proteins in vertebrates and tissue distribution of triiodophenol in Rana catesbeiana tadpolesKiyoshi Yamauchi
Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422 8529, Japan
Comp Biochem Physiol C Toxicol Pharmacol 153:328-35. 2011..thyroid hormone disrupting chemical, with serum proteins from rainbow trout (Onchorhynchus mykiss), bullfrog (Rana catesbeiana), chicken (Gallus gallus), pig (Sus scrofa domesticus), and rat (Rattus norvegicus) using a [(125)I]TIP ..
- Characterization of iodothyronine sulfotransferase activity in the cytosol of Rana catesbeiana tadpole tissuesFarhana Babli Rahman
Graduate School of Science and Engineering, Shizuoka University, Shizuoka 422 8529, Japan
Gen Comp Endocrinol 166:396-403. 2010We have investigated the sulfation of thyroid hormones (THs) in the cytosol from Rana catesbeiana tadpole tissues...
- Dynamic state and evoked motility in coupled hair bundles of the bullfrog sacculusC E Strimbu
University of California, Los Angeles Department of Physics and Astronomy and the California NanoSystems Institute, 475 Portola Plaza, Los Angeles, CA 90095, USA
Hear Res 265:38-45. 2010..In both of these systems, hair bundle motion phase-locked by the electrical signal was found to induce movement in the overlying structures...
- Acute neurosteroid modulation and subunit isolation of the gamma-aminobutyric acidA receptor in the bullfrog, Rana catesbeianaD M Hollis
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
J Mol Endocrinol 32:921-34. 2004..Thus, neurosteroid modulation of the GABA(A) receptor was investigated in the brain of the bullfrog (Rana catesbeiana) using the mammalian GABA(A) receptor agonist [(3)H]muscimol...
- Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channelsAndrei S Kozlov
Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Nat Neurosci 10:87-92. 2007..This feature assures the concerted gating of transduction channels that maximizes the sensitivity of mechanoelectrical transduction and enhances the hair bundle's capacity to amplify its inputs...
- Genetic evidence for female-biased dispersal in the bullfrog, Rana catesbeiana (Ranidae)James D Austin
dagger Department of Biology, Queen s University, Kingston, Ontario, Canada K7L 3N6
Mol Ecol 12:3165-72. 2003..We predicted female-biased dispersal in the bullfrog (Rana catesbeiana) based on aspects of their mating system and tested this prediction using data from seven polymorphic DNA ..
- Input and output characteristics of collision avoidance behavior in the frog Rana catesbeianaKeisuke Yamamoto
Department of Brain Science and Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu, Fukuoka 808 0196, Japan
Brain Behav Evol 62:201-11. 2003..07, F(2,14) = 0.46 and F(2,14) = 0.70, respectively; at 4 m/s, F(2,15) = 0.50, F(2,14) = 0.68 and F(2,14) = 0.41, respectively, p > 0.05). Thus, frog collision avoidance behavior seems to have an all or none-like property...
- Identification of immunoreactive plasma and stomach ghrelin, and expression of stomach ghrelin mRNA in the bullfrog, Rana catesbeianaHiroyuki Kaiya
Department of Biochemistry, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
Gen Comp Endocrinol 148:236-44. 2006In this study, we established a radioimmunoassay (RIA) specific for ghrelin from the bullfrog Rana catesbeiana using a novel antibody raised against the C-terminal amino acid sequence of bullfrog ghrelin [13-28]...
- Collision-sensitive neurons in the optic tectum of the bullfrog, Rana catesbeianaHideki Nakagawa
Department of Brain Science and Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka, Japan
J Neurophysiol 104:2487-99. 2010..This strongly suggests that the collision-sensitive neurons of the frog comprise a threshold detector, which triggers collision avoidance behavior...
- Representation of waveform periodicity in the auditory midbrain of the bullfrog, Rana catesbeianaA M Simmons
Departments of Psychology and Neuroscience, Brown University, Box 1853, Providence, RI 02912, USA
J Assoc Res Otolaryngol 1:2-24. 2000..They further show that a populationbased analysis can increase the precision with which temporal features are represented in the central auditory system...
- Rana catesbeiana virus Z (RCV-Z): a novel pathogenic ranavirusSai Majji
Department of Microbiology, University of Mississippi Medical Center, Jackson, Mississipi 39216, USA
Dis Aquat Organ 73:1-11. 2006A virus, designated Rana catesbeiana virus Z (RCV-Z), was isolated from the visceral tissue of moribund tadpoles of the North American bullfrog Rana catesbeiana...
- Direct current electrical conduction block of peripheral nerveNiloy Bhadra
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
IEEE Trans Neural Syst Rehabil Eng 12:313-24. 2004..The results indicate that electrical currents generally produce a conduction block due to depolarization of the nerve membrane, resulting in an inactivation of the sodium channels...
- Analysis of the Rana catesbeiana tadpole tail fin proteome and phosphoproteome during T3-induced apoptosis: identification of a novel type I keratinDominik Domanski
Department of Biochemistry and Microbiology, University of Victoria, PO Box 3055, Victoria, BC V8W 3P6, Canada
BMC Dev Biol 7:94. 2007..This process has been intensively studied at the genomic level yet very little information at the proteomic level exists. In addition, there is increasing evidence that changes in the phosphoproteome influence TH action...
- Enhancement of sensitivity gain and frequency tuning by coupling of active hair bundlesKai Dierkes
Max Planck Institute for the Physics of Complex Systems, Nothnitzer Strasse 38, 01187 Dresden, Germany
Proc Natl Acad Sci U S A 105:18669-74. 2008..We relate our findings to the situation in the bullfrog's sacculus and the mammalian cochlea...
- Plasma membrane Ca2+-ATPase extrudes Ca2+ from hair cell stereociliaE N Yamoah
Department of Physiology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
J Neurosci 18:610-24. 1998..Our data further indicate that PMCA could elevate the extracellular Ca2+ concentration close to hair bundles above the low level found in bulk endolymph...
- Compressive nonlinearity in the hair bundle's active response to mechanical stimulationP Martin
Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA
Proc Natl Acad Sci U S A 98:14386-91. 2001..This scaling behavior, also found in the response of the mammalian basilar membrane to sound, signals the operation of an amplificatory process at the brink of an oscillatory instability, a Hopf bifurcation...
- NMR and biophysical elucidation of structural effects on extra N-terminal methionine residue of recombinant amphibian RNases from Rana catesbeianaChun Hua Hsu
Department of Agricultural Chemistry, National Taiwan University, Taipei 106, Taiwan
J Biochem 148:209-15. 2010..NMR techniques, and the results were compared with those of their authentic RNases extracted from oocytes of Rana catesbeiana. Although the overall structures of the recombinant and authentic proteins are almost identical, the extra N-..
- Why islands are easier to invade: human influences on bullfrog invasion in the Zhoushan archipelago and neighboring mainland ChinaLi Yiming
Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, 25 Beisihuanxi Road, Haidian, 100080, Beijing, China
Oecologia 148:129-36. 2006..We compared invasion success (the probability of establishing a wild reproducing population) for bullfrogs (Rana catesbeiana) introduced to enclosures on 26 farms on islands in the Zhoushan archipelago and 15 farms in neighboring ..
- Aquaculture enclosures relate to the establishment of feral populations of introduced speciesXuan Liu
Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang, Beijing, China
PLoS ONE 4:e6199. 2009..Our findings are the first to quantify the importance of improving farming enclosures to control and minimize the risk from introduced species...
- Developmental changes in central O2 chemoreflex in Rana catesbeiana: the role of noradrenergic modulationStéphanie Fournier
Department of Pediatrics, Universite Laval, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec City, QC, Canada
J Exp Biol 210:3015-26. 2007The in vitro brainstem preparation from Rana catesbeiana shows a functional central O(2) chemoreflex. Acute brainstem exposure to hypoxic superfusate elicits lung burst frequency responses that change over the course of development...
- Survival of bundleless hair cells and subsequent bundle replacement in the bullfrog's sacculeJonathan E Gale
Department of Otolaryngology, HNS, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
J Neurobiol 50:81-92. 2002..The results indicate that sensory hair cells can undergo intracellular self-repair in the absence of mitosis, offering new possibilities for functional hair cell recovery and an explanation for non-proliferative recovery...
- Oxygen sensitive chemoreceptors in the first gill arch of the tadpole, Rana catesbeianaC Straus
Department of Medical Physiology, Faculty of Medicine, University of Calgary, AB, Canada
Can J Physiol Pharmacol 79:959-62. 2001Spike frequency was recorded in the nerve of the isolated superfused first gill arch of the bullfrog larva, Rana catesbeiana and the response to different superfusate PO2 was evaluated...
- Avoidance response of juvenile Pacific treefrogs to chemical cues of introduced predatory bullfrogsD P Chivers
Department of Biology, University of Saskatchewan, Saskatoon
J Chem Ecol 27:1667-76. 2001Bullfrogs (Rana catesbeiana), native to eastern North America, were introduced into Oregon in the 1930's. Bullfrogs are highly efficient predators that are known to eat a variety of prey including other amphibians...
- THE effects of tonic lung inflation on ventilation in the American bullfrog Rana catesbeiana ShawC E Sanders
Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia, V6T 1Z4, Canada
J Exp Biol 204:2647-56. 2001....
- Ca2+ changes the force sensitivity of the hair-cell transduction channelEunice L M Cheung
Department of Engineering and Applied Science, Harvard University, Cambridge, Massachusetts, USA
Biophys J 90:124-39. 2006..In addition, we characterized a faster, voltage-dependent "flick", which requires intact tip links but not current through transduction channels...
- Hair bundles are specialized for ATP delivery via creatine kinaseJung Bum Shin
Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
Neuron 53:371-86. 2007..Consistent with this critical role in hair bundle function, the creatine kinase circuit is essential for high-sensitivity hearing as demonstrated by hearing loss in creatine kinase knockout mice...
- Mass mortality associated with a frog virus 3-like Ranavirus infection in farmed tadpoles Rana catesbeiana from BrazilRolando Mazzoni
Instituto de Investigaciones Pesqueras, Facultad de Veterinaria, Universidad de la Republica, Montevideo, Uruguay
Dis Aquat Organ 86:181-91. 2009..been recently associated with mass mortality events in Brazilian farmed tadpoles of the American bullfrog Rana catesbeiana Shaw, 1802. The objectives of the present study were to further characterize the virus isolated from sick R...
- Development of the respiratory response to hypoxia in the isolated brainstem of the bullfrog Rana catesbeianaRachel E Winmill
Department of Biological Sciences, California State University, Hayward, Hayward, CA 94542, USA
J Exp Biol 208:213-22. 2005..We hypothesize that the cessation of respiratory activity in post-metamorphic tadpoles and adults is an adaptive, energy-saving response to low oxygen...
- Mechanical leverage in the middle ear of the American bullfrog, Rana catesbeianaYehudah L Werner
Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Hear Res 175:54-65. 2003..But dissection of Rana catesbeiana ears showed: the extracolumella, as long as the columella, is proximally expanded in the vertical plane, ..
- Hair-bundle movements elicited by transepithelial electrical stimulation of hair cells in the sacculus of the bullfrogD Bozovic
The Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 100:958-63. 2003..A model for electrically driven bundle motion that incorporates the negative stiffness of the hair bundle as well as its two mechanisms of motility captures the essential features of the measured responses...
- Coding of amplitude modulation in the auditory midbrain of the bullfrog (Rana catesbeiana) across metamorphosisS S Boatright Horowitz
Department of Neuroscience, Brown University, Providence, RI 02912, USA
J Comp Physiol A 184:219-31. 1999..These data suggest that different neural codes for processing of the periodicity of complex signals operate in early stage tadpoles than in postmetamorphic froglets...
- The unitary event underlying multiquantal EPSCs at a hair cell's ribbon synapseGeng Lin Li
The Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
J Neurosci 29:7558-68. 2009..We propose that the large EPSCs reflect the highly synchronized release of multiple vesicles at single presynaptic ribbon-type active zones through a compound or coordinated vesicle fusion mechanism...
- Molecular identification of the skin transformation center of anuran larval skin using genes of Rana adult keratin (RAK) and SPARC as probesYuji Ishida
Laboratory of Developmental Biology, Department of Biological Science, Graduate School of Science, Hiroshima University, 1 3 1, Kagamiyama, Higashihiroshima, 739 8526, Japan
Dev Growth Differ 45:515-26. 2003..This suggestion was tested by investigating the effect of SPARC on cultured larval basal cells. We observed that SPARC suppressed the expression of rak, but not rlk...
- Induction of differentiation rescues HL-60 cells from Rana catesbeiana ribonuclease-induced cell deathChyou Wei Wei
Graduate Institute of Life Sciences, National Defense Medical Center, 114, Taipei, Taiwan
FEBS Lett 531:421-6. 2002b>Rana catesbeiana ribonuclease (RC-RNase) exerted strong anti-tumor activity and its cytotoxicity was shown to correlate with differentiation stages of three different hepatoma cell lines...
- The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran developmentNik Veldhoen
Department of Biochemistry and Microbiology, P O Box 3055, STN CSC, University of Victoria, Victoria, British Columbia V8W 3P6, Canada
Aquat Toxicol 80:217-27. 2006..induces changes in the thyroid hormone-mediated process of metamorphosis of the North American bullfrog, Rana catesbeiana and alters the expression profile of thyroid hormone receptor (TR) alpha and beta, basic transcription ..
- Controlling for the effects of history and nonequilibrium conditions in gene flow estimates in northern bullfrog (Rana catesbeiana) populationsJames D Austin
Department of Biology, Queen s University, Kingston, Ontario, Canada, K7L 3N6
Genetics 168:1491-506. 2004..We determined the scale at which gene flow can be estimated among breeding aggregations of bullfrogs (Rana catesbeiana) at the northern limit of their range in Ontario, Canada, using seven highly polymorphic DNA microsatellite ..
- Emerging pathogen of wild amphibians in frogs (Rana catesbeiana) farmed for international tradeRolando Mazzoni
Instituto de Investigaciones Pesqueras, Montevideo, Uruguay
Emerg Infect Dis 9:995-8. 2003..We report the causative agent, Batrachochytrium dendrobatidis, in North American bullfrogs (Rana catesbeiana) farmed for the international restaurant trade...
- Residues involved in the catalysis, base specificity, and cytotoxicity of ribonuclease from Rana catesbeiana based upon mutagenesis and X-ray crystallographyYing Jen Leu
Institute of Biomedical Sciences and the Institute of Molecular Biology, Academia Sinica, Taipei 115, and the Department of Life Science, National Tsing Hua University, Hsin Chu 300, Taiwan
J Biol Chem 278:7300-9. 2003The Rana catesbeiana (bullfrog) ribonucleases, which belong to the RNase A superfamily, exert cytotoxicity toward tumor cells...
- Detection of environmental endocrine-disruptor effects on gene expression in live Rana catesbeiana tadpoles using a tail fin biopsy techniqueN Veldhoen
Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada
Environ Toxicol Chem 20:2704-8. 2001We describe a novel method of rapidly assessing exposure of premetamorphic Rana catesbeiana tadpoles to endocrine-disrupting chemicals...
- Spontaneous oscillation by hair bundles of the bullfrog's sacculusPascal Martin
Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10021 6399, USA
J Neurosci 23:4533-48. 2003..These observations accord with a model in which oscillations arise from the interplay of the hair bundle's negative stiffness with the activity of adaptation motors and with Ca 2+-dependent relaxation of gating springs...
- Frog p26olf, a molecule with two S100-like regions in a single peptideNaofumi Miwa
Department of Biology, Graduate School of Science, Osaka University, Osaka 560 0043, Japan
Microsc Res Tech 60:593-9. 2003An S100-like calcium-binding protein, p26olf, was originally isolated from the frog (Rana Catesbeiana) olfactory epithelium with four chromatographical steps...
- Vibrometric studies of the middle ear of the bullfrog Rana catesbeiana I. The extrastapesMatthew J Mason
Department of Physiological Science, UCLA, 405 Hilgard Avenue, Los Angeles, CA 90095, USA
J Exp Biol 205:3153-65. 2002..was used to measure the vibration velocity at different points on the ossicular apparatus of the bullfrog Rana catesbeiana in response to free-field sound...
- Symbiotic fermentation, digesta passage, and gastrointestinal morphology in bullfrog tadpoles (Rana catesbeiana)Gregory S Pryor
Department of Zoology, University of Florida, Gainesville, 32611 8525, USA
Physiol Biochem Zool 78:201-15. 2005..to compare gut structure and inhabitants, digesta passage, and microbial fermentation in bullfrog tadpoles (Rana catesbeiana) to those in other herbivores...
- Myosin-1c interacts with hair-cell receptors through its calmodulin-binding IQ domainsJanet L Cyr
Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
J Neurosci 22:2487-95. 2002..The calcium-sensitive binding of calmodulin to myosin-1c may therefore modulate the interaction of the adaptation motor with other components of the transduction apparatus...
- Parvalbumin 3 is an abundant Ca2+ buffer in hair cellsStefan Heller
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
J Assoc Res Otolaryngol 3:488-98. 2002..Parvalbumin 3 is therefore a significant mobile Ca2+ buffer, and perhaps the dominant buffer, in many types of hair cell. Moreover, parvalbumin 3 provides an early marker for developing hair cells in the frog, chicken, and zebrafish...
- Ryanodine receptor isoforms of non-Mammalian skeletal muscleYasuo Ogawa
Department of Pharmacology, Juntendo University, Tokyo, Japan
Front Biosci 7:d1184-94. 2002..Taking these findings into consideration, we conclude that CICR is too slow to explain the physiological Ca2+ release on depolarization...
- Lineage of anuran epidermal basal cells and their differentiation potential in relation to metamorphic skin remodelingKen ichi Suzuki
Developmental Biology Laboratory, Department of Biological Science, Graduate School of Science, Hiroshima University, 1 3 1 Kagamiyama, Higashihiroshima 739 8526, Japan
Dev Growth Differ 44:225-38. 2002..In this culture, larval basal cells differentiated into adult basal cells that reconstituted the adult epidermis. Thus, it was concluded that larval basal cells are the direct progenitor cells of the adult epidermal stem cells...
- Differential effects of voltage-dependent inactivation and local anesthetics on kinetic phases of Ca2+ release in frog skeletal muscleGustavo Brum
Departamento de Biofisica, Facultad de Medicina, Montevideo, Uruguay
Biophys J 85:245-54. 2003....
- Novel Rana keratin genes and their expression during larval to adult epidermal conversion in bullfrog tadpolesK Suzuki
Department of Biological Science, Graduate School of Science, Hiroshima University, Higashihiroshima, Japan
Differentiation 68:44-54. 2001The conversion of the larval to adult epidermis during metamorphosis of tadpoles of bullfrog, Rana catesbeiana, was investigated utilizing newly cloned Rana keratin cDNAs as probes...
- Molecular cloning and functional expression of a skeletal muscle dihydropyridine receptor from Rana catesbeianaJ Zhou
Department of Molecular Biophysics and Physiology, Rush University, Chicago, Illinois 60612, USA
J Biol Chem 273:25503-9. 1998..and Tanabe, T. (1997) J. Gen. Physiol. 110, 379-389). This molecule constitutes a new tool for studies of excitation-contraction coupling, gating, modulation, and gene expression...
- Unifying the various incarnations of active hair-bundle motility by the vertebrate hair cellJean Yves Tinevez
Laboratoire Physico Chimie Curie, CNRS, Institut Curie, Paris, France
Biophys J 93:4053-67. 2007....
- Characterization of the binding of [3H]CGP54626 to GABAB receptors in the male bullfrog (Rana catesbeiana)Matthew J Asay
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
Brain Res 1094:76-85. 2006..to determine the pharmacology of putative receptors in the brain of an anuran amphibian, the male bullfrog (Rana catesbeiana)...
- Mechanics of the inner ear of the bullfrog (Rana catesbeiana): the contact membranes and the periotic canalA P Purgue
Department of Physiological Science, UCLA, Los Angeles, CA 90095 1606, USA
J Comp Physiol A 186:481-8. 2000..morphological measurements of the periotic canal based on internal casts of the inner ear in the bullfrog (Rana catesbeiana) revealed that it is divided into a wide, tapered section and a narrower section comprised of two branches ..
- Selectively suppressed Ca2+-induced Ca2+ release activity of alpha-ryanodine receptor (alpha-RyR) in frog skeletal muscle sarcoplasmic reticulum: potential distinct modes in Ca2+ release between alpha- and beta-RyRT Murayama
Department of Pharmacology, Juntendo University School of Medicine, Tokyo 113-8421, Japan
J Biol Chem 276:2953-60. 2001..These results suggest that alpha-RyR in the SR may serve Ca(2+) release in a mode other than CICR, being selectively suppressed in CICR...
- Apoptosis during the seasonal spermatogenic cycle of Rana catesbeianaEstela Sasso-Cerri
Department of Morphology, Dental School, Sao Paulo State University UNESP, Araraquara, Brazil
J Anat 209:21-9. 2006In the bullfrog Rana catesbeiana, testicular weight is constant throughout the year, but the volume densities of germinative and interstitial compartments undergo inverse changes from winter (non-breeding) to summer (breeding)...
- A model for energy flow in the inner ear of the bullfrog (Rana catesbeiana)A P Purgue
Department of Physiological Science, UCLA, Los Angeles, CA 90095 1606, USA
J Comp Physiol A 186:489-95. 2000..Our model explains the main features of the empirical data obtained from direct measurement of the amphibian papilla and basilar papilla contact membranes reported in an accompanying paper (this issue)...
- Decreased cyclin-dependent kinase activity promotes thyroid hormone-dependent tail regression in Rana catesbeianaRachel C Skirrow
Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
Cell Tissue Res 328:281-9. 2007..Coincubation with PD098059, a MAPK inhibitor, has no effect. Thus, T(3)-dependent tail regression does not require MAPKs, but a decrease in Cdk2 activity promotes tail regression...
- Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptationP D Calvert
Howe Laboratory of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
J Gen Physiol 111:39-51. 1998..Therefore, cGMP-dependent regulation of transducin GTPase is likely to occur only during prolonged bright illumination...
- Activation patterns and length changes in hindlimb muscles of the bullfrog Rana catesbeiana during jumpingJ M Olson
Department of Biology, Villanova University, Villanova, PA 19085, USA and Biology Department, Northeastern University, Boston, MA 02115, USA
J Exp Biol 201:2763-77. 1998We measured the electromyographic (EMG) activity of seven hindlimb muscles during jumping in the bullfrog Rana catesbeiana. The semimembranosus, gracilis major, gluteus magnus, adductor magnus, cruralis and plantaris longus were ..
- Recoverin has S-modulin activity in frog rodsS Kawamura
Department of Physiology, Keio University School of Medicine, Tokyo, Japan
J Biol Chem 268:14579-82. 1993..Here, we show that recoverin has similar activity as S-modulin, and the amino acid sequences of both proteins are similar. The results strongly suggest that recoverin is bovine S-modulin and regulates PDE activation...
- Relationship between steroidogenesis and spermiation in Rana catesbeiana and Leptodactylus ocellatusCinthia Rosemblit
Laboratorio de Endocrinología Comparada and PRHOM CONICET, Departamento de Biodiversidad y Biologia Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
J Comp Physiol B 176:559-66. 2006..system to analyse the role of steroid hormones in hCG-induced spermiation in two species of anuran amphibian: Rana catesbeiana and Leptodactylus ocellatus...
- Solitary hair cells are distributed throughout the extramacular epithelium in the bullfrog's sacculeJ E Gale
Department of Otolaryngology HNS, University of Virginia School of Medicine, Charlottesville 22908, USA
J Assoc Res Otolaryngol 1:172-82. 2000..It is also possible that they may be produced from cell divisions in the extramacular epithelium that has not been considered capable of giving rise to hair cells...
- Biomechanics of vibration reception in the bullfrog, Rana catesbeianaT E Hetherington
Department of Zoology, Ohio State University, Columbus 43210 1293
J Comp Physiol A 163:43-52. 1988..The role of the OPS in reception of vibrations was examined in bullfrogs (Rana catesbeiana) tested in various postures that manipulated differential motion between the shoulder girdle (the origin of ..
- Thyroid hormone response element-like sequence in anuran matrix metalloproteinase 1 gene is responsive to in vivo thyroid hormone administrationT Sawada
Department of Biological Science, Graduate School of Science, Hiroshima University, Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
J Endocrinol 169:477-86. 2001Gene (Rmmp1) of matrix metalloproteinase 1 (MMP1) of the bullfrog, Rana catesbeiana, has been shown previously to contain a thyroid hormone response element (TRE)-like sequence in its 5'-upstream region...
- Multiple modes of calcium-induced calcium release in sympathetic neurons I: attenuation of endoplasmic reticulum Ca2+ accumulation at low [Ca2+](i) during weak depolarizationM A Albrecht
Department of Neuroscience, Case Western Reserve University, Cleveland, OH 44106, USA
J Gen Physiol 118:83-100. 2001..These results emphasize the importance of the relative rates of Ca2+ uptake and release in defining ER contributions to depolarization-induced Ca2+ signals...
- Multiple modes of calcium-induced calcium release in sympathetic neurons II: a [Ca2+](i)- and location-dependent transition from endoplasmic reticulum Ca accumulation to net Ca releaseJ Hongpaisan
Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
J Gen Physiol 118:101-12. 2001....
- Plasma membrane Ca2+-ATPase isoform 2a is the PMCA of hair bundlesR A Dumont
Department of Physiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Neurosci 21:5066-78. 2001..Because PMCA2a is the only Ca(2+) pump present at appreciable levels in hair bundles, the biochemical properties of this pump must account fully for the physiological features of transmembrane Ca(2+) pumping in bundles...
- Transfer characteristics of the hair cell's afferent synapseErica C Keen
Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
Proc Natl Acad Sci U S A 103:5537-42. 2006..This result implies that, for receptor potentials in the physiological range, the hair cell's synapse transmits information with high fidelity...
- Vibrometric studies of the middle ear of the bullfrog Rana catesbeiana II. The operculumMatthew J Mason
Department of Physiological Science, UCLA, 405 Hilgard Avenue, Los Angeles, CA 90095, USA
J Exp Biol 205:3167-76. 2002..An alternative or additional role for the opercularis system is proposed, involving the protection of the inner ear from high-amplitude displacements of the stapes footplate during breathing and vocalisation...
- Calcium site specificity. Early Ca2+-related tight junction eventsF Lacaz-Vieira
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900 Sao Paulo, Brazil
J Gen Physiol 110:727-40. 1997....
- Habituation and sensitization of aggression in bullfrogs (Rana catesbeiana): testing the dual-process theory of habituationM A Bee
Division of Biological Sciences, University of Missouri-Columbia, USA
J Comp Psychol 115:307-16. 2001The aggressive response of male bullfrogs (Rana catesbeiana) habituates with repeated broadcasts of acoustic stimuli simulating a new territorial neighbor...
- cGMP suppresses GTPase activity of a portion of transducin equimolar to phosphodiesterase in frog rod outer segments. Light-induced cGMP decreases as a putative feedback mechanism of the photoresponse- Arshavsky VYu
Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
J Biol Chem 266:18530-7. 1991....
Research Grants29
- THYROID HORMONE RECEPTORS IN DEVELOPMENTVALERIE GALTON; Fiscal Year: 1999..is to elucidate the mechanisms of action of thyroid hormone (TH) during development using the amphibian Rana catesbeiana (RC) as the animal model. TH is essential for all aspects of development in this species...
- OSMOTIC/IONIC STRESS EFFECTS ON THE AUDITORY PERIPHERYRANDY ZELICK; Fiscal Year: 1999..in two species of anuran amphibians - a toad (Bufo marinus) which is dehydration-tolerant and a frog (Rana catesbeiana) which is dehydration-sensitive...
- SEXUAL DIMORPHISM IN NEUROPEPTIDE SYSTEMSSUNNY BOYD; Fiscal Year: 1992..The specific animal to be used in the amphibian Rana catesbeiana. Recent evidence demonstrates that the same steroid and neuropeptide hormones control reproduction in both ..
- Thyroid hormone action in the developing eyeMark Schneider; Fiscal Year: 2003..it is essential for all post-embryonic stages of development and metamorphosis, and in this laboratory the Rana catesbeiana (RC) tadpole has proved to be an excellent vertebrate model in which to study the actions of TH in ..
- ANURAN SCREENING ASSAY FOR ANTITHYROID COMPOUNDSTYLER LINTON; Fiscal Year: 1999..We propose to follow urea synthesis in TH-challenged prometamorphic Rana catesbeiana tadpoles as an indicator of thyroid status, and hence of potential antithyroid activity...
- INITIATION OF THE HEARTBEAT--A VOLTAGE-CLAMP STUDYWayne Giles; Fiscal Year: 1980..3-4 mm) of tissue which are dissected from the sinus venosus region of the heart of the American bull-frog, Rana catesbeiana. The preparation and certain necessary refinements of this method have been developed within the last two ..
- NEUROETHOLOGY OF VOCAL COMMUNICATIONAndrea Simmons; Fiscal Year: 2006..abstract_text> ..
- CALCIUM DYNAMICS AND INTRACELLULAR SIGNALINGDavid Friel; Fiscal Year: 2005....
- SENSORY NEURON ADDITION IN RATPAUL FAREL; Fiscal Year: 2002..We will also determine whether the presumed population of type-L neurons differs from nature sensory neurons in the functional differentiation. ..
- EXCITATION CONTRACTION COUPLING IN SKELETAL MUSCLEJULIO VERGARA; Fiscal Year: 2002....
- GI MUCOSAL BARRIER IN HEALTH AND SURGICAL DISEASESusan Hagen; Fiscal Year: 2008..abstract_text> ..
- FGF Regulation of GnRH NeuronsPei San Tsai; Fiscal Year: 2008..In addition, it will reveal if mutations on other genes encoding FGFs/FGFRs are also candidates for these human disorders. ..
- HAIR CELL RESPONSES TO OTOTOXIC DRUGSPETER STEYGER; Fiscal Year: 2007..This may lead to new co-therapeutic treatments with aminoglycosides and (cellular) aminoglycoside-uptake inhibitors against a wider range of bacterial infections. ..
- Use of an Amphibian as an Alternative Model to Evaluate Effects of Contaminants oMichelle Boone; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Mammalian skeletal muscle: a recombinant protein factoryJULIO VERGARA; Fiscal Year: 2006..unreadable] [unreadable]..
- From infra- to ultrasound: Diversity in acoustic processing by the vertebrate earPeter M Narins; Fiscal Year: 2010..Ultimately, our research may lead to new therapeutic approaches to treatment of hyperacusis and noise-induced tinnitus, two known syndromes in which efferent system malfunction has been implicated. ..
- Confocal Microscope for the BIDMC Imaging Core FacilitySusan Hagen; Fiscal Year: 2006..The instrumentation is requested because no like equipment is currently available to members of the major or minor user groups within the applicant institution or in the Longwood Medical area. [unreadable] [unreadable] [unreadable]..
- HAIR CELL REGENERATION IN THE VESTIBULAR OTOLITH ORGANSRichard Baird; Fiscal Year: 2001....
- HAIR-BUNDLE PROTEOMICSPeter Gillespie; Fiscal Year: 2004..These experiments will allow us to identify the major proteins of the bundle and allow us to focus on proteins functionally important for bundle function. ..
- Functional similarities in renal and cochlear epitheliaPETER STEYGER; Fiscal Year: 2004....
- ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIESVIRGINIA MILLER; Fiscal Year: 2002..The experiments of this proposal take such an approach using molecular to integrated whole animal physiology. ..
- WETLAND URBANIZATION GRADIENTS AND VECTOR BORNE DISEASESJOSEPH KIESECKER; Fiscal Year: 2002..Development of mathematical models for these trematode systems will provide a template for studies of other snail borne diseases with similar community modules, for example, schistosomiasis. ..
- Gene expression in regenerating adult vertebrate CNS.Judith Chapman; Fiscal Year: 2006..Genes will be compared with those implicated in normal development and with models incapable of CNS regeneration. ..
- Hair-Bundle LipidsPeter Gillespie; Fiscal Year: 2009..Together, the experiments in this proposal will allow us to determine how lipids regulate transduction and adaptation. ..
- Quantifying Hair Bundle ComponentsPeter Gillespie; Fiscal Year: 2008..abstract_text> ..
- Insight from Lamprey Genome: Structure-Function studies of Novel GnRH ReceptorsSTACIA SOWER; Fiscal Year: 2008..Studying the lamprey genome is a touchstone for understanding genes that arose in the vertebrates and offers an innovative approach to therapeutic research. [unreadable] [unreadable] [unreadable]..
- ROLE OF CALCIUM PUMPING IN HAIR-BUNDLE FUNCTIONPeter Gillespie; Fiscal Year: 2004..If re-expression of PMCA2 in hair cells rescues auditory function in these otherwise PMCA2-deficient mice, the key location of PMCA2 in the ear must be the hair cell. ..
- Excitation-contraction Coupling in Normal and Dystrophic Mammalian MuscleJULIO VERGARA; Fiscal Year: 2008..abstract_text> ..
- Expression of KCC4 in distal colon surface epitheliaCOLLEEN TALBOT; Fiscal Year: 2006..It is anticipated that a long-term collaboration will be established between the Fellow and the Sponsor, further helping to track these students to research careers at a major doctoral granting institution. ..

subset: commoncrawl


text:
26 September 2017
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The mission of WHO is the attainment by all peoples of the highest possible level of health.
Vacancy Notice No:
Technical Officer
Contract type:
Fixed-term Appointment
Duration of contract:
1 year
17 June 2013
Application Deadline:
8 July 2013
Vacancy Filled
Duty Station:
Geneva, Switzerland
Organization unit:
CRE Compliance, Risk Management and Ethics Office
Located within the DGO cluster, the mission of CRE is to systematically identify organization-wide risks, and by topic area, maintain a risk register record, evaluate it according to its likely impact and probability, and proactively have it managed by risk management owners.
The CRE will seek to periodically review, assess and integrate internal control compliance into all policies and managerial decisions.
The CRE will promote and uphold the highest organizational standards, codes of conduct and core values. Through the ethics function the goal is for all staff to observe and perform their functions consistent with the highest standards of integrity required of WHO staff members and international civil servants.
The CRE will liaise independently with internal parties across the different levels of the Organization, developing and presenting to the Director-General its annual work plan of delivery of compliance, risk management, and ethics needs across the three levels of the Organization.
Description of duties:
Under the broad direction of the Director CRE, The Technical Officer (Ethics) provides ethics advice to all staff in all WHO offices. Through the advisory process, the Officer assists staff in making ethical decisions that serve the interest of the Organization.
The Officer proactively explores and advises on the establishment of policies and processes, bearing in mind risk assessment, and with a view to promoting an ethical culture.
Provide confidential advice to staff on ethical issues, including corporate ethical standards and personal conflict of interest situations such as the receipt of gifts, respectful workplace and other ethical concerns.
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Advocate the promotion of high ethical standards with all staff, including managers, in coordination with relevant units such as human resources, legal, finance, procurement, internal audit and investigation, and the ombudsman.
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Carry out the annual declaration of interest exercise for staff further to Staff Rule 110.7, in consultation with LEG as necessary. This will include the selective verification of representation statements; reviewing filed statements and advising the Director-General's Office on the resolution of any actual or perceived conflicts of interest, including possible remedial action.
Communicate to staff on the objectives of the declaration of interest policy to encourage full compliance.
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Advanced university degree in Law, relevant Ethics/Philosophy, Business Administration, Public Administration, or related field.
Experience in training of trainers, coaching, mediation and conflict management.
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At least 10 years of national and international professional and progressive work experience in complex public and/or private institutions in values and ethics or conduct and discipline, ethics and compliance programmes, codes of conduct or ethics, accountability & compliance frameworks; management of financial disclosure policies and/or whistleblower protection policies.
Experience with working in a multi-national setting with people from different cultural backgrounds. Preferably with WHO and/or other UN agency. Recognized relevant certification and knowledge of current best practices relating to ethics and conduct would be an asset.
Preferably with WHO and/or other UN agency experience.
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text: I agree with the others. My brother is a III--any future brothers would have just gotten a name they'd have liked. I'm not sure he would have gotten a family name, because honestly, the only boys' in my family are John something or other, essentially. I suppose he could have gotten Christopher, after my mom's brother, or possibly Smith, for my mom's maiden name, but I don't think they were really in love with either of those. My mom really didn't want a John Robert, III, to begin with, but she gave in because my dad clearly wanted one so bad. So if I had a second brother, he probably would have been just something they liked. Levi, or Matthew, or Andrew, or Charlie, maybe... My dad didn't (and doesn't!) like Charlie, but I can imagine my mom would get it since she told my dad she wouldn't accept his proposal if he didn't promise she wouldn't have to have a John Robert, III. :)


text:
Dr. A.Celestine Raj Manohar M.D.,
Dr. A.Celestine Raj Manohar M.D., (14-2-1957 / Coimbatore, Tamilnadu, India)
Poems by Dr. A.Celestine Raj Manohar M.D., : 617 / 4322
Dear God… - Poem by Dr. A.Celestine Raj Manohar M.D.,
You are the Potter!
We are the clay;
You made us better,
Than what we say.
You gave us good shape,
And soul inlay;
We behave like ape
Often, some day!
If we had cracks,
That came some way,
Do plug all the leaks,
God, we all pray!
Let's hold the water,
You pour in us;
What's the matter?
What's the fuss?
You know us too well;
You know our hearts;
You know where we fell;
You know our parts.
Help us to do well,
What You approve;
And let the world tell,
Greatest is God's love!
Copyright by Dr John Celes 7-9-2010
Listen to this poem:
Poems by Dr. A.Celestine Raj Manohar M.D., : 617 / 4322
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Poem Submitted: Tuesday, September 7, 2010
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I Do Not Love You Except Because I Love You
Pablo Neruda


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Stanbic Bank Ghana has announced that celebrated Jazz musician, Peter White, will headline its maiden edition of the Stanbic Ghana Jazz Festival to be held in Accra from May 9 to 10.
Peter White, who is a smooth jazz fusion guitarist, would be backed by a local band and supported by artistes such as Oli Silk, Ofie Kodjoe, Acka Blay and a few other local artistes.
This would be Peter White's second visit to Ghana, and Stanbic Bank seeks to generate new levels of interest and support for jazz and encourage jazz lovers to preserve and promote the genre.
The festival would kick-off with an invite-only event on Friday, May 9 and followed by an open to public show on Saturday, May 10, both at the Omanye Hall, Labadi Beach Hotel.
The festival is being organised by Stanbic Ghana in collaboration with Smooth Jazz Ghana and Live FM.
Speaking at the media launch, Head of Marketing and Communications, Mawuko Afadzinu said, 'We hope to make the Stanbic Bank Ghana Jazz Festival a stop on the global jazz calendar by presenting top-flight musicians to the people of Ghana. As a bank, our association with such world class pool of talent is to buttress the point that we aim to deliver world class service.'
He noted that his outfit's aim is to nurture and promote the development of both the visual and performing arts in the country, encouraging engagement and social interaction.
'We want to contribute in positive ways to develop and grow the music industry thereby providing employment, training and skills development in all the related fields of technical production including sound engineering and lighting, marketing and PR, event management and hospitality,' he added.
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RECIPES: Recipe Details
The Berry Best Black Burger with Provolone Cheese
The inspiration for this burger was sitting around with some friends sipping wine & nibbling on fruit, cheese, nuts & salami. It was a wonderful combination and it would seem to be a perfect pairing with a good burger & a glass of Merlot.
Ingredients –
½ cup toasted black walnut pieces – after toasting, chop fine
2 ½ lbs of ground black angus chuck
4 TBS of seedless black berry jam
1 ½ tsp liquid smoke
2 tsp Grey Poupon dijon mustard
2 TBS Sutter Home Merlot wine
1 tsp Jamacian all spice
1 tsp. Ground nutmeg
3 TBS chopped chives
2 tsp salt
1 tsp pepper
Additional ½ cup of seedless black berry jam for Basting Burgers as they Cook
Colavita Olive Oil for brushing the grill racks
6 slices of Aged Provolone Cheese – to melt over the burgers
6 Kaiser rolls from the bakery, split horizontally
12 tsp. of Grey Poupon Dijon Mustard
6 leaves of butter crunch or bib lettuce
Step by Step Instructions – Burgers: Start the grill and preheat (15 mins) to a temperature of 450 degrees. Heat a small pan over high heat on the grill. Add the ½ cup black walnut pieces and toast to release the flavors & oils. Remove, place in a small food chopper, pulse grind until ground fine. Set aside till you make the burgers. Turn off the grill. In a large bowl place the 2 ½ lbs of ground black angus chuck, 4 TBS of seedless black berry jam, 1 ½ tsp liquid smoke , 2 tsp Grey Poupon dijon mustard, 2 TBS Sutter Home Merlot wine, 1 tsp Jamacian all spice, 1tsp. Ground nutmeg, 2 tsp salt , 1 tsp pepper. Chop 3 TBS of chives and add to the bowl. Then add your cooled ½ cup toasted black walnuts. Then mix all the above ingredients well. Separate the mixture into 6 equal parts and form into patties. Grease the grill racks with the Colavita Olive Oil. Start the grill and preheat (15 mins) to a temperature of 450 degrees. Place burgers onto the grill and close the lid, let cook 4 to 5 mins. Turn the burgers to create grill marks, baste with the additional ½ cup of seedless black berry jam & cover, cook another 3 to 4 mins. Flip burgers, baste with the additional ½ cup of seedless black berry jam, cover and cook 3 to 4 mins. Turn burgers to create grill marks, baste with the additional ½ cup of seedless black berry jam, cover & cook another 2 mins. Then For the last 2 mins. of cooking, place 1 slice of Aged Provolone Cheese onto each burger to melt the cheese. Remove from heat. During the entire time you are cooking the burgers, you are trying to maintain a grill temperature of 400 to 450 degrees. To plate: Slice the Kaiser rolls horizontally, keeping tops with their partners. Place the bottom of the Kaise on the plate, spread each bottom with 1 tsp. Grey Poupon Dijon Mustard. Then top mustard with the Butter Crunch lettuce leaves. Top with the burger. Spread the top of the Kaiser with 1 tsp Grey Poupon Dijon Mustard. Place the lid of the Kaiser on top and serve. 2006 – ToniLee M. Monteparte


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Illinois Ban on Carry Ruled Unconstitutional (See Page 7)
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December 13, 2012, 10:57 PM
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Location: Illinois
Posts: 439
What I find interesting about this case is that it could have national consequences. If Lisa Madigan wants to appeal to the US Supreme Court, it could invite justices to expand earlier decisions and in effect limit restrictions on concealed carry in other states besides Illinois. Could the Justices rule that "may issue" laws in states like California, Massachusetts and New York are unconstitutional, and that all states must be shall issue? New York City and Washington DC CCW bans too could be ruled unconstitutional. After all, the Illinois Appellate ruling basically said the CCW ban violates a constitutional right to bear arms "outside the home". If Madigan wants to fight this all the way to the Supreme Court, national gun control advocates better be careful what they wish for, because if the US Supreme Court concurs with the Illinois Appellate Court, ramifications go far beyond Illinois.
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The King's English And River Oaks' too.
As events (as opposed to just plain shows) go, the well-heeled soiree surrounding local keyboardist Paul English's Stude Hall release party for his debut CD Beauty was a gem. The lobby of Rice U's Alice Pratt Brown music building is appropriately pale, grand, and shorn of all ornamental interest, allowing clean lines of sight to the collection of financially secure jazz fans, patrons d'art, comp-tickets regulars and the sort of people who get invitations to stuff at Rice because their trust fund helped buy the building or something. There were even several exquisite examples of the Texas Society Warhorse -- long assumed extinct by we of the cash-strapped strata who consider a night at Rockefeller's a twice-yearly extravagance -- but on the town in full big-haired, leather-skinned, gold-sequined finery this night. The weather was nice, the crowd dressed up, and it felt good to be alive.
Which is a nice feeling, but it don't always last. Though it's not what I usually choose to listen to, I like Paul English's music. I admire his talent, I respect the range of his musical interests and I find it downright stubborn that English continues to ply his trade here in Houston, to Houston's benefit, even though he has pretty well grown beyond our struggling jazz scene and into the West Coast majors. The release gala for Beauty seemed designed to prove just that last point, flaunting as it did Brooklyn's cocky bass virtuoso John Patitucci, Yellowjackets drummer William Kennedy and, most impressively, mega sax-star and former Houston homeboy Kirk Whalum.
Much was made in the program notes of the mutual-admiration society and good-will reunion of English and Whalum, who played together in English's group in '79 and '80, but I guess the good will didn't extend to Whalum's fee for the performance: the music started at 9:00 and I left at 10:30, having seen neither hide nor hair of Whalum. I can only assume that Whalum was simply too pricey to use for a full set, because for someone attending a reunion, he couldn't have been too anxious to get on the stage. I think I'm safe in guessing that the Warhorses stood as a bloc and cheered heartily when Whalum was finally trotted out for a doubtless crowd-pleasing turn on his horn.
But the majority of the show -- 'scuse me, event -- was spent in frustration at the obviously gargantuan talent on stage being confined to the volumatic and emotional range of wind blowing through the trees. Patitucci is simply too arrogant a player to have resisted a few awe-inspiring solo flights, and Kennedy also got a chance to step out early on, but saxman David Caceres didn't seem up to his surroundings quite often enough -- the energy remained, for the most part, tame. Part of that, of course, was by virtue of the fact that English played some numbers off Beauty, which is an album of ballads, but even the bop standards never caught fire. From gallery seats I could see a hall full of fancy dresses and snappy suits, and more than a few seemed to be slumping between bouts of obligatory applause. My date -- who, as usual, had quicker mental access to a pithy summation than I -- waited two songs before sighing sleepily: I feel like I'm at Whole Foods. The rest of the evening, as far as it went, was endurance.
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You can take the guy out of the bar, but you can't make him go away... Even I, who have known Pete Selin for less time than most anyone else in town, was more than a little skeptical some months back when the former Bon Ton Room owner (and former Club Hey Hey proprietor) called to say he was leaving the music biz that done treated him so bad. He was closing the Bon Ton Room, concentrating on his Blues Burgers restaurant on Old Market Square and, he said at the time, converting the Bon Ton into a just-plain-bar. Since then, Emo's folk took over the Bon Ton and turned it into Emo's Live (a.k.a. the Shimmy Shack), and it started to look like Selin might really be getting out of the business.
Yeah, well, the phone rings the other day, and guess who. Selin and a partner, it turns out, have taken over a building on Kirby that I remember as the Crown and Serpent, and are busy turning it into the Big Easy Social and Pleasure Club, a full-service bar to which is appended Yeah You Right Records, a specialty shop featuring blues-, roots-, Cajun- and zydeco-oriented records, collectibles and memorabilia. And yes, contrary to Pete's every well-intentioned promise, there'll be live music every Saturday night, featuring some people calling themselves Big Daddy Gumbeaux and the Big Easy Rhythm Rockers. And yes, Friday night music is a possibility too, and maybe Sunday afternoon zydeco, if things go the right way.
Selin's the first one to admit that the new venture is geared toward the aging demographic of blues and roots fans (now all you Marty Racine groupies know where to hang), and the tavern's proximity to Rice Village could be the stroke of logistic fortune the Bon Ton never enjoyed.
"Haven't heard a single gunshot," says Selin.
The Big Easy opens doors at 5731 Kirby on Saturday, February 19, with Nawlins pianist John King Cleary.
No local record releases again this week, but again, there's some damn ferners in town peddling their wares. They're from Dallas, and they're called Course of Empire, and the new album that's getting such a big push from Zoo Entertainment is called Initiation. Pretty palatable polished pop metal, with lyrics covering that existentially disaffected terrain that guarantees you're getting genuinely alternative music and not some icky commercial imitation. Hell, I can bob and sway to that. Saturday, February 19 at Abyss.
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You are hereKali Ornelas
Kali Ornelas
Touch yourself at the most important depth of your personal journey
Meet Kali Ornelas
The Self-Understanding component of YOSSUM elevates these yoga retreats to a profound, consciousness-raising dimension. You will receive valuable guidance from Kali Ornelas, YOSSUM's founder, to help you understand yourself in ways that you probably never did before. Most participants regard the YOSSUM Process a turning point in their lives.
Enlightenment is not the end, but the means. Realizing that virtue is her goal, Kali accepts the long and often arduous cultivation that is necessary to attain it. She quietly shoulders whatever responsibilities fall to her. Unattached to her accomplishments, taking credit for nothing at all, she guides the whole world by guiding the individuals who come to her.
She shares her divine energy with her students, encouraging them, creating trials to strengthen them, even scolding them to awaken them, directing the streams of their lives toward the infinite ocean of the Tao."
Kali Ornelas touches many lives
Kali stands centered in an incredible flow
Traveling world-wide, Kali shared that she is booked in advance for several years.
I told her that I hold space, and that I have nothing scheduled even for next month. That feels very different for me. People organize in different ways.
The Yossum Team is united in certain ways to interact is and channel participant's interests. I am in continual discovery. Nothing to say that discovery doesn't take place in many formats?
Kali easily meets this very moment


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There are few Japanese car companies that enjoy as rosy an image in North America as Nissan does when it comes to two-door sport coupes. While other manufacturers from their native land such as Toyota and Honda hoarded their fun to drive coupes in the 1970's for the domestic market, Nissan (then called Datsun) wowed the world with the 1970 240Z. This small but not undersized vehicle proved to be an overwhelming success for the company, and it helped to create an image for Nissan that transcended the standard economy car and hatchback perception that most Japanese automakers enjoyed overseas at the time. The 240Z would be produced continuously throughout the decade, seeing several upgrades in both horsepower and engine size in order to better compete with other sports cars from Jaguar and Porsche.
In the 1980's, the Z car tradition was kept alive through a procession of cars that would slowly increase in size until the sports coupe had fully morphed into a grand touring vehicle. The first real growth spurt occurred in 1980 with the debut of the 280ZX, which added luxury equipment and a longer wheelbase in order to better satisfy American buyers. With a generous 180 horsepower, the 280ZX was still capable of turning in hot laps, but after four years of production Nissan once again tinkered with their formula to create the powerful 300ZX.
The 300 ZX represented the culmination of the horsepower wars that were underway on the streets of Japan in the mid-80's. Adding a more powerful turbo engine to the coupe, Nissan increased the output of the ZX to 230 ponies. It wasn't until 1990, however, that Nissan really took the gloves off with a re-designed version of the 300ZX which churned out 300 turbocharged horsepower. Unfortunately, while the vehicle was an excellent performer, it had bulked up to the point where it had little in common with the original spirit of the 240Z.
After several years of hiatus, used car buyers can once again take advantage of Nissan's penchant for two-door performance with the 350Z coupe. This attractive, quick and well-engineered vehicle is an attractive option for those in the market for a used coupe in the tradition of the original Z car. This article examines both the performance details and design aspects of the 2003 - 2007 Nissan 350Z in order to illustrate what makes it one of the best used coupe bargains available.
2003 - 2007 Nissan 350Z
With so much riding on the history of the fabled Z cars, Nissan had to pull out all the stops in order to ensure that the new for 2003 350Z didn't disappoint performance fans. While the 2003 - 2007 Nissan 350Z is larger than the original 240Z, it is considerably lighter than the previous generation of vehicle to bear the Z moniker, namely the 300ZX. Combined with a powerful engine and excellent driving dynamics, the 350Z is an excellent balanced between the nimble agility of coupes past and the comfort and features list that modern buyers expect.
The 2003 - 2007 Nissan 350Z is well served by a sports-oriented edition of the company's 3.5-liter VQ V-6 engine. There were several revisions made to this motor over the course of the 350Z's evolution. Producing 287 horsepower when it debuted, in 2005 a 35th Anniversary edition of the car bumped the engine's numbers up to 300 ponies, a figure which would further rise to 306 in 2007 when ordered with a manual transmission. Torque actually fell somewhat from 274 lb-ft to 268 over the same period of time. All versions of the car can be outfitted with either a 5-speed automatic or 6-speed manual transmission, and depending on trim level aggressive braking packages and other track-ready features can also be added to the vehicle.
The 350Z is best suited as a GT car, given its 3,100 lb curb weight and substantial dimensions. Convertible editions of the vehicle can add several hundred more pounds to the platform. Adding to its grand touring status is a well-appointed cockpit, which can be adorned with such features as automatic climate control, power everything, comfortable heated leather sport seats and DVD navigation. The 350Z is a very comfortable two-seater which feels much more spacious inside than some of the other sport coupes on the market.
The 2003 - 2007 Nissan 350Z is one of the most mature used coupes available, and its plethora of configurations and excellent power and comfort make it a standout on secondhand car lots across the country.


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Lake Forest, IL
Professor of Speech, Voice, Acting, Musical Theater and Opera75/hour
...joyful experience for students young and old. I want to eliminate the fear behind writing phobias. I want to empower students of all ages to to feel confident in their ability to communicate effectively... read moreSee Tutors Like This


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|Gracedale Gazebo
Dr. Stuart Shapiro, President of the Pennsylvania Health Care Association, has stated that privatization has, in virtually all cases, improved the quality of care for residents. This is because private sector companies can afford to make capital improvements, unlike cash-strapped counties.
Northampton County's nursing home, Gracedale, post-referendum, is now rated by Medicare at just two stars, which is "below average" and lower than the "average" rating it had pre-referendum,. Inspections reveal that the facility has failed to ensure that doctor's orders are followed; has failed to notify doctors of adverse changes in residents' medical conditions; ad has failed to resolve some resident grievances. I will acknowledge that Gracedale staff really do care about the residents and will often volunteer their own time and money to make their lives more comfortable. I saw that myself last year during Family Fest.
In contrast to Gracedale, Lehigh County nursing home Cedarbrook has a rating of four stars, which is "above average."
Updated 9:40 AM: A private buyer was selected in Blair County yesterday.


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Coin-Op Boy
The Last Starfighter
The Arcade Video Game PCB by
Atari, Inc.
Emulated in MAME !
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[ARCADE] Arcade Video Game PCB
The Last Starfighter © 1984 Atari.
An alien entrepreneur has placed Starfighter games machines on Earth as a test for prospective Starfighters. Although Starfighter appears to be another arcade game, it contacts the alien when the high score record is broken.
Alex, a 19-year old who lives in a trailer park, is an ace at Starfighter and gets whisked off to the planet Rylos as a draftee to combat the evil Xur and the Ko-Dan armada. Having been fooled into coming, Alex refuses and is returned to Earth. While Alex is gone from Rylos, a Ko-Dan attack destroys all the Gunstar ships (Starfighters) and crews, except for a prototype equipped with a special weapons system called Death Blossom.
Alexis, meanwhile, changes his mind and, with the help of the alien, returns to Rylos where, with Navigator/Pilot Grigg, he takes off in the last Gunstar to take on the whole enemy fleet. Fighting through a series of space battles, Alex and Grigg succees in saving the universe and then return to earth to pick up Alex's girlfriend before assuming the role of commander of Rylos armed forces and being given the hero treatment on Rylos.
Player controls weapons on Gunstar and orientation of Gunstar chair; he is not piloting ship. Player's head-up display shows information on weapons system and coolant (shields), as well as on currently targeted enemy, surrounding enemy positions and Gunstar chair orientation. Not all information is available in each round.
Each of the enemy ships takes a different amount of energy to destroy. Enemy condition is shown by the 'Target temperature gauge'. When the enemy temperature hits max, it will explode. The rate at which the gauge rises is determined by the type of ship. Temperature rises while player's lasers are contacting enemy ship and may fall if this ceases before destruction.
The condition of the Gunstar is shown by the 'Hull temperature gauge'. When the Gunstar is being hit by the enemy fire, the hull temperature increases. When the hull temperature gets high, coolant flows in (around the gauge on screen from the on-screen reservoir) to coll the hull. This depletes the reservoir of coolant. If no coolant remains, the hull temperature will reach maximum and the Gunstar is destroyed. A coolant recharge is given at the end of a complete round.
Player's laser energy is shown for each side laser. Laser energy decreases with time of laser use and increases far more slowly. This encourages short bursts of fire from one laser at a time. If both lasers are fired simultaneously, a third laser also fires from below without additional depletion of energy, but with additional effect on the target. This contradictorily encourages use of both lasers simultaneously. As players increase in skill, they will learn to use shot, single laser bursts on small targets and twin laser bursts on large targets. This combination will ensure best energy usage and maximum destructive effect. It is possible for a player to be stranded with inadequate energy and be destroyed of insufficient ability to retaliate, but this cannot happen on beginner rounds where energy drain is very low.
Death Blossom (laser blossom) is fired with rear buttons on Star Wars controller. The central circle will light up on screen to show when Death Blossom is charged and usable. Activation causes the screen to be blanketed with laser fire destroying (or greatly heating up if mother ship) all targets on screen. Does not destroy Control Tower and Xur's transport.
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CPU: Motorola 68000, TMS32010
In 1984 a movie called 'The Last Starfigter' (from now called TLSF). It was a Sci-fi adventure movie. It was the first movie ever to be made were all the special effects (except explosions and make up) was made on a computer. The computer was a Cray X-MP. This and the fact that space movies were very popular in this time made everyone expecting this movie to be a big blockbuster like Star Wars. This is why Atari bought the rights for the movie so they would be able to make a game based on it. It was going to be released on both home consoles and on an arcade. The arcade was never finished.
The production of the game was started in Atari's arcade division. The original project team was made up of Chris J. Horseman (Project leader), Jim Morris (Project engineer (software)), Jack Ritter (2nd project engineer (software))
and Barry Whitebook (Animation). Ted Michon and Mike Albaugh came onboard on this project later in the development. Prior arcade games to use 3-D was only vector games. Atari had for several years worked on a general purpose 3-D arcade system, but it was always 'a few years away' every time they wanted to use it (an arcade game called "
I, Robot
" was actually released in 1983, and this game had solid 3-D but this game was hard coded and was very different from TLSF, this was actually the first game developed by Atari that was programmed with C). This is where Ted Michon comes into the picture. Ted worked as a consultant for Atari and developed a super high bit mapped system with a polygon fill engine. Atari decided to use this to on the TLSF arcade. They also had to use the systems expanding capabilities to implement a math box that could handle the 3-D transformations. The programming of the math box was done by Mike Albaugh.
The programming of the arcade was done mainly by Jim Morris. The additional programming with the cave sequence on the game was done by Jack Ritter. Jack came onboard from Cinematronics.
In the programming process Jim used a 68 000 Motorola 16bit CPU, the first to ever be used at Atari. The programming language was C. It was also used several 3-D tools that later also were used in other games. TLSF became a pioneer in using the 68 000 CPU. Earlier most games were made with the 6502 CPU. The arcade games "Hard Drivin" (1988) and "Stun Runner" (1989) have a very similar graphics with TLSF game, even though another graphic engine was used on these games.
The gameplay in the game was taken right from the gameplay in the movie and scenes from the movie; this was often done with spinoff games like this. The game was actually very similar with what you see in the movie, at least regarding the graphic. The controller on the game was a controller
from the "
Star Wars
" vector games that Atari made. When Atari choosed to drop the game is was about 75% finished. There was no cabinet for the game, but the game worked and it could be played on a test bench. It was also made some simple sound effects for the game.
The reason behind Atari's decision to cancelled the game so far into production was several. Atari had for some years pay'ed much money to the movie companies for the rights to produce games with themes taken from movies. This rights costed Atari a lot of money over a long time. Atari gambled on the movie to become the success that everyone predicted, but this did not happen. The film didn't fail, but it wasn't a success either. In the production of the arcade they found out that the machine would have a sell price of 10 000$, and this was a lot of money back in the 80's. If the movie had been a big success this price could have been defended. The vice president in Atari thought that no one would buy a game for 10 000$. And not long after the project team got the message that the game was cancelled. On the same time Atari was in deep financial problems that was caused by Atari's consument division. On the top of all this came the big video game crash. The result was that Atari started to fall and fall, until it was closed in the end. The original arcade division of Atari was shutdown in 2001 when Midway choose to shutdown Midway West (Midway had bought Atari Games (Atari`s arcade division) and changed name to Midway West). Prior to this Atari had been sold a couple of times, and the leaders had also been changed more than once. But Atari never became the company it was prior to the crash. Some ears after Atari cancelled TLSF arcade game, the arcade game Hard Drivin was released. This game sold for the same price that TLSF had (10 000$).
Ships destroyed increases score by ship value, multiplied by a distance bonus; i.e., if an expert can hit a ship while distant, he will receive more points than a novice who hits when close.
Each round ship scores increases.
Hitting two ships at one scores 4 times the single ship value.
Project leader :
Chris Horseman
Project Engineer (Software) :
Jim Morris
3-D Hardware :
Ted Michon
Math Box Programming :
Jack Ritter
Mike Albaugh
Barry Whitebook
Machine's picture.
Håkon Galstad information
Game's ROM.


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quote:Originally posted by CornbreadAnything Roy Rogers had was good too...Roast Beef tasted like Roast Beef and their chicken was always fresh...whatever happened to them?
quote:Originally posted by Drewmcdan1Roy Rogers' Double R-Bar burger. It was a burger with ham and cheese on top. Smothered the top roll with Roy's Horsey sauce and BBQ sauce and a few onions. I miss Roys and the few left at the highway rest stops are a poor remnant of the original outlets. There are a few real Roys centered around Frederick, MD.
quote:Originally posted by AdjudicatorI remember the Wendy's Hot Dogs; they were pretty good.Other's include:Onion Rings @ Popeye'sFried Mushrooms @ Dairy QueenSuper Bar @ Wendy'sBig Twin @ Hardee's (1970's; cooked on their air grill)Original FF @ McDonald'sFried Jalepeno Poppers @ Burger KingThe Lum's chain in generalThe original Domino's (In early 80's, before they changed both the sauce and dough recipe, their sausage vendor, and also before the switched to cooking in the chain ovens)
quote:Originally posted by Poverty PeteJumbo double bacon butterburger? The name alone is enough to send me to the cardiac ward!
quote:Originally posted by Adjudicatorquote:Originally posted by Poverty PeteJumbo double bacon butterburger? The name alone is enough to send me to the cardiac ward!HEY!!! Let's talk about it... I'll call you around 3:30 AM tomorrow morning.That's 615-642-xxxx, RIGHT???
quote:Originally posted by rmcielwain Just passed by my local Hardees today & what's back for a limited time?: Big Twin - 2 for $3


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The 2009 D.I.C.E Summit wrapped up on Friday and there's a few more interviews and Pitt previews that you might want to check out.
We start at Gamespot, where Richardo Torres interviewed Pete to find out more details on The Pitt (slated for release next month on Xbox LIVE and Games for Windows LIVE). To check it out, just hit play on the video above.
Over at G4, you can get more information on the Pitt with hands-on impressions from Brian Leahy. Here's a quick look (caution: some details could be considered spoilerific)…
"Disguising myself as a slave and giving up all of my items, I travelled into the heart of the slave community. The slaves are put to work in steel mills making materials that have made The Pitt the industrial envy of the wasteland. To fit into my new role as a slave, I've been put to work collecting steel ingots in a scrapyard. In doing so, I meet the Trogs, a new type of enemy for Fallout 3. At the core, they are ghouls, but different. Apparently, most of the slaves end up as Trogs. I'm guessing it's just how the mutations from radiation manifest themselves in The Pitt. They are hunched over more than the ghouls you're used to, but are just as easily dispatched. Collecting all the ingots nets a perk that increases the melee damage which is perfect for the new Auto-Axe weapon."
Wrapping up this weekend update, GameSpy did a series of interviews with developers at D.I.C.E — including sit downs with Todd and Emil.