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WOODCLIFF LAKE, N.J., June 16, 2014 /PRNewswire/ -- Eisai Inc. announced today that a Phase III clinical trial (study 332) of its in-house-discovered AMPA receptor antagonist perampanel has met its primary endpoint in patients with primary generalized tonic-clonic (PGTC) seizures, a severe form of seizures.
Study 332 was a double-blind, randomized, placebo-controlled, multicenter, parallel-group trial to evaluate the efficacy and safety of adjunctive perampanel therapy in 164 patients aged 12 years and older with uncontrolled PGTC seizures receiving one to a maximum of three anti-epileptic drugs. Patients were randomized to receive perampanel or placebo in a 1:1 ratio. An analysis of the trial data demonstrates that perampanel met its primary efficacy endpoint (reduction in seizure frequency per 28 days).
The most frequently reported adverse events in this trial (>10% in the perampanel arm and greater than placebo) were dizziness, fatigue, headache, irritability and somnolence.
Based on the results of this trial, Eisai plans to submit an application to the U.S. Food and Drug Administration for an indication expansion to include the adjunctive treatment of PGTC seizures in the first half of fiscal year 2014.
FYCOMPA® (perampanel) CIII is currently approved as an adjunctive treatment for partial-onset seizures with or without secondary generalized seizures in patients with epilepsy aged 12 years and older.
About Primary Generalized Tonic-Clonic Seizures
Epilepsy affects over 2.2 million people in the United States. Generalized seizures account for approximately 40% of all epilepsy, and Primary Generalized Tonic-Clonic (PGTC) seizures are one of the most common and most severe forms of generalized seizures. For the majority of patients, a PGTC seizure begins with a loss of consciousness without any prior warning symptoms and a sudden contraction of the tonic muscles, causing the patient to fall down (tonic phase). This is followed by violent convulsions (clonic phase) until the muscles finally relax, and the patient is left with a disturbance of consciousness. While the seizure generally only lasts a few minutes, the patient often feels confused, groggy or drowsy for a longer period of time before returning to normal.
Important Safety Information
Serious Psychiatric and Behavioral Reactions
Hostility- and aggression-related adverse reactions occurred in 12% and 20% of clinical trial patients randomized to receive FYCOMPA at doses of 8 mg and 12 mg/day, respectively, compared to 6% of patients in the placebo group. These effects were dose-related and generally appeared within the first 6 weeks of treatment, although new events continued to be observed through more than 37 weeks. These effects in FYCOMPA-treated patients led to dose reduction, interruption, and discontinuation more frequently than placebo-treated patients. The combination of alcohol and FYCOMPA significantly worsened mood and increased anger. Patients taking FYCOMPA should avoid the use of alcohol. Patients, their caregivers, and families should be informed that FYCOMPA may increase the risk of psychiatric events. Patients should be monitored during treatment and for at least one month after the last dose of FYCOMPA, and especially when taking higher doses and during the initial few weeks of drug therapy (titration period) or at other times of dose increases.
Suicidal Behavior and Ideation
Antiepileptic drugs (AEDs), including FYCOMPA, increase the risk of suicidal thoughts or behavior in patients. Anyone considering prescribing FYCOMPA or any other AED must balance the risk of suicidal thoughts or behavior with the risk of untreated illness. Epilepsy and many other illnesses for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior. Patients, their caregivers, and families should be informed of the risk and advised to monitor and immediately report the emergence or worsening of depression, suicidal thoughts or behavior, thoughts about self-harm, and/or any unusual changes in mood or behavior. Should suicidal thoughts or behavior emerge during treatment, consider whether the emergence of these symptoms in any given patient may be related to the illness being treated.
Dizziness and Gait Disturbance
FYCOMPA caused dose-related increases in events related to dizziness and disturbance in gait or coordination. Dizziness and vertigo were reported in 35% and 47% of patients randomized to receive FYCOMPA at doses of 8 mg and 12 mg/day, respectively, compared to 10% of placebo-treated patients. Gait disturbance related events were reported in 12% and 16% of patients randomized to receive FYCOMPA at doses of 8 mg and 12 mg/day, respectively, compared to 2% of placebo-treated patients. These adverse reactions occurred mostly during the titration phase.
Somnolence and Fatigue
FYCOMPA caused dose-dependent increases in somnolence and fatigue-related events. Somnolence was reported in 16% and 18% of patients randomized to receive FYCOMPA at doses of 8 mg and 12 mg/day, respectively, compared to 7% of placebo patients. Fatigue-related events were reported in 12% and 15% of patients randomized to receive FYCOMPA at doses of 8 mg and 12 mg/day, respectively, compared to 5% of placebo patients. In the controlled Phase 3 epilepsy clinical trials, these adverse reactions occurred mostly during the titration phase. Patients should be advised against engaging in hazardous activities requiring mental alertness, such as operating motor vehicles or dangerous machinery, until the effect of FYCOMPA is known.
Falls were reported in 5% and 10% of patients randomized to receive FYCOMPA at doses of 8 mg and 12 mg/day, respectively, compared to 3% of placebo-treated patients.
Withdrawal of AEDs
A gradual withdrawal is generally recommended with antiepileptic drugs to minimize the potential of increased seizure frequency.
Most Common Adverse Reactions
In clinical trials, the most frequently reported dose-related adverse reactions in patients receiving FYCOMPA 8 mg or 12 mg vs placebo (>4% and at least 1% higher than the placebo group) included dizziness (36% vs 9%), somnolence (16% vs 7%), fatigue (10% vs 5%), irritability (9% vs 3%), falls (7% vs 3%), nausea (7% vs 5%), ataxia (5% vs 0%), balance disorder (4% vs 1%), gait disturbance (4% vs 1%), vertigo (4% vs 1%), and weight gain (4% vs 1%).
Drug Interactions
FYCOMPA may decrease the efficacy of contraceptives containing levonorgestrel. Plasma levels of FYCOMPA were decreased when administered with carbamazepine, phenytoin and oxcarbazepine. Concomitant use with strong CYP3A inducers such as St. John's wort and rifampin should be avoided. Multiple dosing of FYCOMPA 12 mg/day enhanced the effects of alcohol on vigilance and alertness, and increased levels of anger, confusion, and depression. These effects may also be seen when FYCOMPA is used in combination with other CNS depressants.
Pregnancy Category C and Lactation
FYCOMPA should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Physicians are advised to recommend that pregnant patients taking FYCOMPA enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry. Caution should be exercised when FYCOMPA is administered to a nursing woman.
Hepatic and Renal Impairment
Use in patients with severe hepatic or severe renal impairment is not recommended. Dosage adjustments are recommended in patients with mild or moderate hepatic impairment. Use with caution in patients with moderate renal impairment.
Drug Abuse and Dependence
FYCOMPA is a Schedule III controlled drug substance and has the potential to be abused or lead to drug dependence.
Please see the FYCOMPA (perampanel) CIII Full Prescribing Information
About FYCOMPA (perampanel)
FYCOMPA is an oral medication and is the first FDA-approved non-competitive AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) glutamate receptor antagonist. Glutamate is the primary excitatory neurotransmitter in the central nervous system. The precise mechanism by which FYCOMPA exerts its antiepileptic effects in humans has not been fully elucidated. FYCOMPA is approved in more than 35 countries.
Epilepsy is a therapeutic area of focus for Eisai. The company continues to make further contributions to help address the diversified needs of epilepsy patients and their families as part of its corporate human health care (hhc) mission.
Eisai Inc.
At Eisai Inc., human health care is our goal. We give our first thoughts to patients and their families and helping to increase the benefits health care provides. As the U.S. pharmaceutical subsidiary of Tokyo-based Eisai Co., Ltd., we have a passionate commitment to patient care that is the driving force behind our efforts to help address unmet medical needs. We are a fully integrated pharmaceutical business with discovery, clinical, manufacturing and marketing capabilities. Our key areas of commercial focus include oncology and specialty care (Alzheimer's disease, epilepsy and metabolic disorders). To learn more about Eisai Inc., please visit us at www.eisai.com/US.
Eisai Inc. has affiliates that are part of a global product creation organization that includes R&D facilities in Massachusetts, New Jersey, North Carolina and Pennsylvania, as well as a global demand chain organization that includes manufacturing facilities in Maryland and North Carolina. Eisai's global areas of R&D focus include neuroscience; oncology; metabolic disorders; vascular, inflammatory and immunological reaction; and antibody-based programs.
Media Inquiries
Investor Inquiries
Laurie Landau
Alex Scott
Eisai Inc.
SOURCE Eisai Inc.


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Stay Tuned Given the Royal DVD Treatment
When I popped Stay Tuned into the DVD player, I really didn't know what to expect. I recalled having seen trailers for it back in 1992, but I'm not sure it got beyond the major markets during its theatrical run, and it's on no one's list of the decade's 10 best.
I suffered through the first half hour, as TV-obsessed Roy Knable (John Ritter) nearly destroys his marriage and family because he can't pull himself away from the boob-tube any longer than it takes to earn the money to pay his cable bill. Roy's new satellite dish promises even more thrills, but, as it turns out, those thrills aren't exactly what he'd planned on. He and his wife (Pam Dawber) are sucked into the microwave ether and begin a seemingly endless journey as active participants in a succession of inane programs, jumping from one channel to another, controlled by a demonic host (Jeffrey Jones) who has designs on their souls.
If the concept of crossing over into TV Land sounds familiar, it should be noted that Stay Tuned predated the vastly superior Pleasantville by seven years. But after a tedious first act, Stay Tuned plays less like a coherent story than a series of loosely connected Saturday Night Live skits. That was likely its downfall in the theater, but it works better, up to a point, on video. As on SNL, not all of Stay Tuned's humor clicks. But I found enough here to keep me amused in a guilty-pleasure sort of way, particularly a bit in which the villain is a mechanical cat. I'll say no more, to avoid spoiling the film's funniest and most clever sequence.
For a movie with no buzz, Stay Tuned has received elaborate treatment from Warner. Most movies with similar track records turn up on DVD, if at all, in cheap pan&scan editions. But this disc includes a "making of" featurette, trailers, and a good if unexceptional anamorphic video transfer. The biggest surprise—for what is clearly a B- or even a C-movie—is the all-new Dolby Digital 5.1 soundtrack. But it doesn't sound particularly special—it's listenable, but not noticeably better than a good Dolby Surround mix.
I'm not sure I can recommend buying Stay Tuned without risking a pitchfork- and torch-bearing siege by the townsfolk, but there's enough mindlessly diverting fun here for an evening's rental.

subset: commoncrawl


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Washington, Feb 2 (ANI): Pakistan has long viewed the various Islamic ilitias it created and helped fund -- including the Taliban -- as useful eapons in its arsenal, low-cost ways to keep its historic foes, India and Afghanistan off balance.
According to Fareed Zakaria, the editor of Newsweek International, when the United States invaded Afghanistan, it did not defeat al-Qaeda and its supporters among the Taliban. They simply fled to Pakistan, their original home.
For Islamabad to genuinely renounce these groups, therefore, it would require a fundamental strategic rethinking within the Pakistani military.
The civilian government in Pakistan, although weak and ineffective, is allied with the international community on these issues. It, too, wants a Pakistani military that knows its boundaries, does not run militant groups and conceives of the country's national interests in less confrontational terms.
He says that of all the tasks facing General David Petraeus, the chief of the U.S. Central Command, and newly appointed U.S. special envoy Richard Holbrooke, the above issue will be the hardest. Zakaria is of the view that if Pakistan cannot solve this problem; the war in Afghanistan cannot be won.
Admitting that the offensive in Afghanistan is not going well, he says that while the U.S. Army is being asked to do enough in Afghanistan, staying focused on a core mission and ensuring its success would require the stakeholders to go through four steps, each more complicated than the last.
The first step would be to carry out counter-insurgency operations in a right manner. He is of the view that so far the American troops in Afghanistan have largely relied on more old-fashioned tactics -- raids, search-and-destroy missions and air attacks. He says that General David McKiernan, the U.S. commander in Afghanistan needs to use the addition of two to four U.S. brigades and aamp up of the Afghan army, to execute a modified version of the new counter-insurgency strategy.
Secondly, Zarkaria says efforts should be made to make the Afghan government credible.
"The central government is widely seen as weak, dysfunctional and utterly corrupt. Unfortunately, many of its most corrupt elements are allies of the West and have thus gained a kind of immunity. The most immediate way to enhance the legitimacy of the Afghan government would be to ensure that presidential and local elections take place this year without disruption," he says.
"Elections are only one form of political legitimacy. There should be a much broader effort to reach out to tribal leaders, hold local councils and build a more diverse base of support. The goal should not be a strong central government -- Afghanistan is by nature decentralized -- but a legitimate government with credibility and allies throughout the country," he adds.
Third, he says, there should be an effort to talk to the Taliban, in spite of differences with it on many issues.
"Were elements of the Taliban to abandon al-Qaeda, we would not have a pressing national security interest in waging war against them. In fact, there is a powerful military advantage to moving in this direction. Al-Qaeda is a stateless organization that controls no territory of its own; it can survive and thrive only with a host community. Our objective should be to cut off al-Qaeda from its allies in Afghanistan and Pakistan. Deprived of local support, al-Qaeda would be a much diminished threat," Zakaria claims in his article for Newsweek.
And finally, those involved in the conflict in Afghanistan must realize that the roots of the problem are in Pakistan, and therefore, the leadership there must be convinced to do whatever is needed to neutralize insurgents and terrorists. (ANI)


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...a great future in their business growth supporting global customers.
Austin, TX (PRWEB) June 12, 2014
Scan Mailboxes Co-Founders are pleased to announce that they finally cut the ribbon on June 10 at 2028 East Ben White Blvd, Suite 240. Ambassadors, families, and friends gathered for the opening of this business that launched on April 2, 2014. The co-founders, Chris D. Landry and Ken Brown III, both cut the dark red ribbon with "Austin Chamber of Commerce" embossed in gold.
Prior to the cutting, they said a few words as well as one of the ambassadors, Rene Campos. The founders look forward to a great future in their business growth supporting global customers. Campos added that they have founded the right place and right time to launch, especially with the business' projected growth of at least ten employees within three years. This means opportunities for at least ten families. Along with the rapid growth of Austin's population, they know Scan Mailboxes will benefit many people and businesses. He thanked them for supporting Austin's economic development.
Visitors were able to check out the office where Scan Mailboxes operates and enjoyed hors d'ovueres. Everyone there was able to network and share information.
Scan Mailboxes in the last two months has been able to provide top-notch service using latest technology for customers to receive mail online. The Temporary Mailbox Service was also just implemented to benefit those who are taking short-term leave from their primary homes, but they would like to continue receiving mail electronically without changing their permanent addresses.
When customers' mail and packages arrive directly at Scan Mailboxes' facility, customers get notified of scanned images of front envelopes/packages on the same day. From that point, customers can have full control via an user-friendly website from a computer or any mobile device to request to: open and scan the contents, forward the physical mail to any designated address, shred and recycle contents, or keep them in storage. Customers, who are in the Austin area, can even stop by to pick up their mail and packages at no additional charge.
Anyone can sign up at http://www.scanmailboxes.com and get their own unique assigned Postal Mailbox number to start using this smart service. This service is like using a P.O. Box, except that it is using digital technology to inform customers what mail have arrived, saving physical trips. Furthermore, they are only a click away from directing Scan Mailboxes what to do with their mail. In alignment with Austin's efforts on being environmentally conscious, we also think of ways on reducing carbon footprints.
Scan Mailboxes also provide Registered Agent Service for all Texas companies filed with Texas Secretary of State for $50 per year per company.
There are more exciting news to come. Stay tuned!


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Server Lanka is a web site hosting company based in Sri Lanka. It targets individuals and small businesses for hosting needs. The company offers standard services such as shared hosting, VPS, and dedicated hosting. Different plans are available within each and appear to target individuals on a budget.
Server Lanka offers a wide range of plans covering shared hosting, virtual servers, and dedicated hosting. All its shared hosting plans feature unlimited sub-domains, databases, e-mail and ftp accounts. Plan bandwidth and hard disk space is limited though both increase with costlier plans.
The shared hosting plans are linux-based and feature software such as Apache, PHP, and cPanel. Server Lanka also has Softaculous allowing for easy updates and installs for popular applications such as Wordpress and Joomla. CloudFare technology and disk space on pure SSD technology results in faster response times. Bandwidth monitoring is also available.
Besides shared hosting plans, Server Lanka also has VPS and dedicated server plans. The dedicated server plans vary on the number of cores, CPU speed, and disk space. Overall, plans from Server Lanka are pretty standard and are targeted to individuals and small businesses in Sri Lanka who need low-cost hosting.
Server Lanka features hardware using Intel processors. Its data centers are based in New York, USA. The company allows customers to further customize its dedicated servers to include items such as additional memory, port speeds, and bandwidth. In addition, Server Lanka also has KVM over IP switches that allow customers remote server access.
Server Lanka mentions 24x7 customer support on its website, however only a contact submission form is available. Besides a contact form, articles are posted in its "knowledge base" for self-support. The only other support is free setup for shared and dedicated hosting after plan purchase.
To secure its hosted websites, the company offers a wide variety of security features including anti-virus protection, hacker protection, and password protect directories. In addition, DDOS protection is offered for all its plans.
Dedicated server plans include DDOS protection but an extra fee is charged for shared plans. Server Lanka also makes daily and weekly offsite backups in North America.
Server Lanka guarantees 99.9% uptime through its data centers in New York, USA. It is unclear how this is enforced or what is offered if the site availability is less than guaranteed. For dedicated servers, Server Lanka offers 100% network uptime, power availability, and cooling availability.
Billing is on a monthly basis but Server Lanka gives discounts up to 20% for its shared hosting plans if the customer pays for the whole year up front. However, dedicated server plans do not have discounts. Multiple options for payment are accepted including credit cards and PayPal through 2CheckOut as well as PayZa. Bank drafts are accepted but only in Sri Lanka.
Server Lanka is a hosting company based in Sri Lanka. Its services are ideal for individuals and small business needing low-cost web-hosting plans. The company features several plans for its shared and dedicated hosting. Its plans have many features including important security and backup features. Its dedicated plans have customizable hardware and data centers located in the United States.
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A slump in oil prices has eroded investor confidence in Persian Gulf stock markets, but some analysts are questioning whether such fears that weaker oil revenue will hurt local economies are in fact premature. Read More »
Oct 15, 2014
A slump in oil prices has eroded investor confidence in Persian Gulf stock markets, but some analysts are questioning whether such fears that weaker oil revenue will hurt local economies are in fact premature. Read More »
Investors in Qatar are likely to hold their breath, and cash, this month: Well, at least until FIFA reports on its investigation of the bidding process for the 2022 World Cup – which was awarded to the Arab Gulf country. Read More »
Large Middle Eastern holders of U.S. Treasuries shouldn't worry about the stability of their investments especially as the U.S. economy shows more signs of improvement following the worst recession in a generation, Atlanta Fed President Dennis Lockhart said on Sunday. Read More »
The biggest company in one of the fastest growing sectors in the country plans to hive off and publicly sell a part of its business that arguably has huge potential. And importantly, the cash it gets will likely be returned to shareholders.
A proposition that will likely have most investors buzzing with excitement. Not surprising then that shares of Emaar Properties are up some 6% early in the session on Sunday, after the Dubai-based real estate giant announced plans over the weekend to raise up to $2.4 billion by listing some 25% of its shopping malls and retail business. Read More »
The Middle East is awash with positive sentiment around startups, and a regular flow of accelerators, incubators and venture capital funds have been launching in recent months to the audible cheer of entrepreneurs.
Yet, is it actually getting easier to fund a startup in the Middle East? Yes, but there's still a long way to go.
That was the conclusion of a Google Hangout organised by The Wall Street Journal and a panel of experts in the startup field across the Middle East. Read More »
Egypt might not seem like the ideal place to do business amid political and economic turmoil since the 2011 revolution, but new ventures are still cropping up – helped increasingly by venture capitalists eyeing the longer-term growth potential there.
Incubators such as Flat6Labs, created and funded by Sawari Ventures, are looking to support local startups by providing up to $20,000 in capital, besides mentorship, training, and legal support.
"A lot of young, bright-eyed entrepreneurs need that help," said Ahmed Alfi, founder of Flat6Labs and co-founder of Sawari, a venture capital firm based in Cairo.
Flat6Labs has already invested in about 36 startups in the past two years. It typically acquires a 10-20% stake in the company that joins its mentoring program and aims to invest in startups that have the potential to become leading companies in the Middle East and North Africa region, and not just Egypt. Read More »
Nine years ago, the Dubai government-owned developer Nakheel launched the Palm Deira, the third of three man-made islands planned off the emirate's coast in the early 2000s. Dredging work soon began, but the project was only partly complete by the time Dubai's property-market crash came in late 2008.
Now, however, Dubai's real estate market is rebounding. And like many other local developers, Nakheel is trying to make the best of what's left over from the boom years, re-launching old schemes to suit a new market and new investor appetites. Nakheel said on Tuesday that the beginnings of the Palm Deira have been renamed Deira Island.
That's a practical approach that many other Dubai developers are taking. Emaar Properties, Dubai's biggest private developer, also on Tuesday teamed up with Dubai Holding to re-launch The Lagoons, a project initially planned in 2006. Read More »
The real estate boom returned to Dubai today as investors scrambled to snap up units for sale by one of the region's biggest developers, Emaar Properties.
Eager buyers began queuing for properties in a back room at the Cityscape Global conference as the rumour went round the event that Emaar was selling about 200 units in Downtown Dubai and The Hills.
Fights nearly broke out and a stray cheque book was thrown at the door of the sales room as Emaar staff urged buyers to form an orderly queue. Read More »
The blocks are stacking up nicely for a bumper year on most Persian Gulf stock markets. Only the companies need to deliver now.
The outlook for the six-member Gulf Cooperation Council bloc, which includes some of the largest oil exporters in the world, is buoyant as most governments spend billions of dollars to boost their economies. Besides this, money is also flowing in from some neighboring states amid political unrest in the wider Middle East. Read More »
Middle East Real Time provides analysis and insight on business, economic, social and political trends in the region.


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My friend started a new site: New Testament Ministries
A friend of mine started a new website called "New Testament Ministries." His first post is "Starting from scratch… all over again."
(After I wrote this, I realized that I never asked permission to use my friend's name, and his name is not on the site. So, I'm not going to mention his name here either.)
I met him a couple of years ago online, then we met in person a couple of time: once while we were traveling through his city and again at a workshop in a nearby city. We've had some wonderful, encouraging conversations then and through email.
Here is a brief excerpt from his first post:
I had the opportunity to watch a group of about 25 Christians come together and break out into a spontaneous (but ordered) rendition of what you just read above. It was so refreshing. There were no bulletins, no sitting in rows looking at the back of each others' heads for an hour while listening to a sermon, but it was interactive and participatory. Anyone with something edifying to say (or sing) could do so at virtually anytime. However, what struck me most was two things (1) simplicity, and (2) the obvious, deep love that these people had for Christ and each other. The second point struck me the most. I walked away almost speechless thinking, "this is what I've been missing for so long."
I'm looking forward to reading more from my friend. I hope you'll decide to follow his site also.
11 Comments
Comments are closed. If you would like to discuss this post, send an email to alan [at] alanknox [dot] net.
I just read the first post from a link from another site. Should be good to follow.
By identifying him as a male, you've cut 3.4 billion possibilities out. We're getting close to finding out who this guy is.
Added him to my coveted "Blogs I read daily" sidebar. Internet stardom is sure to follow.
It is like manna from heaven.
You're welcome.
I'm a church planter. I plant churches from scratch. We see people born again, lives changed, families restored, the sick healed etc. I generate much if my own financial support…with the help of my wife, who also has 3 jobs…and partners with me in the ministry…So what's my point! I'm not interested in idealism. I'm not interested in your theories. I study God's Word diligently while I pour my life sacrificially into ministering the Good News to a desperate world and seeking to establish church…alternatively, flexibly, creatively….in any godly way I can. There's nothing spiritual about the set-up of the seating. There's nothing especially spiritual about spontaneity. Personally I believe in the priesthood of all believers; I provoke maximum participation; we do not have a membership; we encourage generous giving…but don't take up offerings. We don't teach tithing. We believe in the manifestations of the Holy Spirit….but I'm interested in idealizing any specific way of 'doing church'….I guess I'm too busy to be distracted by those nuances.
Last line should read 'not interested'…(the frustrations of mobile phone key pads).
Nice one Alan…wish there was less salt water between us…I'd love to have you contribute from your rich wisdom and experience at Amazing Grace church!
Can you believe there are folks who have experienced too much spontaneous church and long to return to a more ordered format? Coming to church expecting to hear another part of a series of teaching from Scripture and finding 'the moving of the Spirit' canning all that in exchange for seemingly random bits of 'word from God' gets frustrating on a regular basis. Especially when these 'words' seem very repetitive and drawn out…is it asking too much to hope speakers (and presumably God) could be concise and organized?).


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(via Celtics.com on Facebook)
An overtime loss in preseason? That says it all.
First up, photo galleries:
Despite the usual "preseason is what it is" rule, the game proved to be interesting in a lot of ways.
Unexpected starter lineup
Despite massive speculation and Doc's talk about experimentation, it ended up being JET and Bass who started alongside Pierce, KG and Rondo. Not Lee, not Sully, not Darko.
Bass seemed to be feeling out his options this time, preferring to drive and finish rather than settling for his usual jumpers.
Crazy bench scoring
I can't remember the last time we had 56 points in bench points, even during preseason games. Lee, Green and Sully are going to be carrying the bench to new heights, seriously. Add Wilcox to the mix, nothing but explosive. Add Bradley's return, bam. If anyone hasn't realised it yet, our bench is insanely loaded with firepower.
This season is gonna be LEGEN-wait-for-it-because-opener-is-a-month-away-but-who-cares-DARY.
Melo's dominance
(via Red's Army)
Melo had 23 points in 23 minutes, was the top scorer in the game and will continue to be a huge factor in the coming season games.
He powered his way past Pierce in the post, expect to see more of this and active help defense in future games. Of course, this is only IF he is willing to continue his post play. He's strong, fast and a good finisher, the only thing that's stopping him from being an overwhelming force in the paint (similar to LeBron) is his pride at being a wing player.
All good, keep it up I say. So long as he continues his selfish domination of the Knicks offense in being a wing player, the chances of winning look pretty good.
The one about poor pick and roll defense
Chandler dunked about a million times on easy pick and rolls, awful defense.
(via meloshipofthering.com)
New signing Chris Copeland (the dude who looks like a lion) abused the Celtics similarly on his rolls to the rim. I guess Woodson basically told him "Look, keep rolling hard after you screen, and keep at it all night until they stop you." Third string dudes had no answer and Copeland scored 21 – that's how the game was won.
All Chandler/Copeland did was to keep rolling hard to the basket, period. I noticed how the Celtic big would be maintaining his distance from the opposing guard, which gave the guard ample space and angle for those lobs. Also, not forgetting the help defense. No one was close enough to take a charge, or even foul the guy.
Would showing hard stop the lobs? Or perhaps, reading the situation better to cover the roll man would be a better option. Sullinger did fine on a couple of possessions, recovering his position enough to stop Copeland in his tracks before he could get to the basket.
Regardless, this is something that needs to be ironed out. I'll vote for KG screaming death threats and smacking everyone repeatedly until they get the hang of pick and roll defense.
Insanely pointless and irrelevant overtime
You could hear the collective groan when overtime was inevitable. Seriously, more of this? At that point, the Celtics lineup consisted of the rookies (Sully, Joseph) and training camp bodies (Smith, Downs, Christmas). The Knicks however, were fielding Kidd and Novak among other scrubs (including star of the night Copeland) – you could tell they really wanted to win.
The Celtics bench guys couldn't buy their way into a decent shot on most possessions if it wasn't thrown down to Sully, they couldn't defend the roll and that's overtime in summary.
Sidenote: Smith seemed more comfortable handling the ball on offense. While Christmas skipped out on PG duties, he was simply maniacal with his energy and hustle on defense. The guy still has got my vote.
I wonder how Kidd felt like, going from a starter role with the Mavs to fighting garbage time with the third string guys.
Sully continues his excellent play
(via Celtics.com on Facebook)
What else can I say? He played smart, always looking to make the right pass or otherwise take it into the low post. He cleaned up the glass to the tune of 7 rebounds (on par with Rondo this game), and scored 14 before he fouled out.
What a great addition to the team this rookie is fast becoming. The best part is, he's shown that he is comfortable playing with starters and/or second unit, he knows when he should be giving the ball and when he should be making his moves. Just a smart, smart guy.
Green and Lee continue to attack the rim
12 points and an emphatic one-handed jam in the face of two Knicks.
Lee with an underhand scoop, check out 0:24. I love his baseline 3/drive routine, such an easy and effective combination.
Man, him and Lee are going to give the rim some TLC in the months ahead, especially when Wilcox returns to reform the three-headed transition monster.
The captain bombs away Sheed-style
1 of 6 from downtown. Is it me or is Pierce lofting too many bombs these days? It began last season, and it's beginning to remind me uncomfortably of the mad bomber Sheed. I like that he has unshakeable confidence in his next shot, but I would like to see more of his usual array of drives, spin moves, pump fakes and stepbacks.
That's all I've got on the game. What do you reckon, a clean kill next time on the Knicks?


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The first clinical study to put induced pluripotent stem (iPS) cells into humans is set to get under way soon in Japan, where an institutional review board at the Institute for Biomedical Research and Innovation gave conditional approval. The Kobe-based Center for Developmental Biology's Masayo Takanashi will test an iPS cell-based treatment for age-related macular degeneration in a small 6-person study. Testing in patients could start as soon as 2014. Story
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Yeah, you could run in those cute walking shoes or older-than-dirt trainers, but please don't. "When you run, you hit the ground with force greater than two times your own body weight," says Jeff Dengate, shoes and gear editor at Runner's World. "Running shoes are built with higher-quality, lightweight materials that help lessen that impact."
While a good pair can easily set you back $100-plus, making the investment now could save you a boatload later in potential doctors and PT bills. Find our top picks of the year here, and be sure your new pair meets the following criteria:
You may unsubscribe at any time.
1. Has enough toe length Feet swell when you run, so aim for a thumbnail-length of space between your longest toe and the end of the shoe. Don't be surprised if you wind up in a ½- or full size larger than your street shoes.
2. Has enough toe width Squished-in toes equal blisters. Make sure there's some wiggle room in the toe box.
3. Skips seams Look for a seamless upper (seams can rub, causing blisters) that comfortably hugs the top of your foot.
4. Has the right arch The arch should contour to the shape of your foot. You may need to add an insert for a more customized fit.
5. Holds your heel Make sure your heel stays in place before buying. Find out with a quick jog around the store (or on the treadmill if they have one).
6. Feels firm Pillowy cushion feels nice, but a firmer shoe is best if you're coming back from an overuse or impact injury; it'll have more spring-back on the road, minimizing stress on stabilizing muscles.
7. Flexes right Check the shoe's flex point (where it creases when you press the toe into the floor). It should bend at the same place as your foot to ensure a natural stride.
MORE: How Running Crushes Your Heart Attack Risk—No Matter How Slow You GoCopyright © 2017 Rodale Inc.
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text:
It's super annoying to waste a Hunter's throwing knife because you're spamming melee in a control point fight. My suggestion would be for the throwing knife to require holding melee down for let's say .3-.5s, and then release to throw, the option to hit reload to cancel would be awesome too.
English#feedback #Hunter #controls #ThrowingKnife
Posting in language:
I think it should only throw if you're facing an enemy out of melee range. I waste mine all the time, just like the warlock and titans only activate if you hit an enemy.
Posting in language:


text: New charges against four foremen end criminal probe of Aracoma fire By Ken Ward Jr. July 1, 2010 Story Share CHARLESTON, W.Va. -- Four Massey Energy foremen were charged Thursday with criminal mine safety violations in a move that federal prosecutors said ends their four-year probe of the fire that killed two workers at the company's Aracoma Alma No. 1 Mine in Logan County.Those charged were Donald R. Hagy Jr., 47, of Gilbert; Terry L. Shadd, 37, of Chapmanville; Edward R. Ellis Jr., 38, of Justice; and Michael A. Plumley, 38, of Delbarton.All four were charged as corporate agents of Massey's Aracoma Coal Co. subsidiary with failing to conduct required mine evacuation drills at the Aracoma Mine in 2005 and 2006, prior to the fatal January 2006 blaze.Each was charged with one misdemeanor count through a document called an "information," typically an indication that the defendants are expected to plead guilty and have cooperated with prosecutors.If convicted, each of the foremen faces a maximum sentence of one year in prison and a $100,000 fine, prosecutors said.In a news release, U.S. Attorney Booth Goodwin said the filing of these charges "concludes the investigation" of the Aracoma fire that killed miners Don Bragg and Ellery Hatfield.The charges come as prosecutors continue a criminal investigation of the April 5 explosion that killed 29 miners at Massey's Upper Big Branch Mine in Raleigh County, and on the same day another Massey miner died at White Buck Coal Co. -- a Massey subsidiary that pleaded guilty to a mine safety crime in 2007. In an unrelated action, federal prosecutors also announced that they had filed felony charges against two surface mine truck drivers for allegedly falsifying training records at the Legacy Resources LLC Synergy Surface Mine No. 1 in Boone County.John R. Wright, 65, of Whitman, and Jeffrey Potter, 44, of Crum, face maximum sentences of five years in prison and $250,000 fines if they are convicted."Coal is vital to this state's economy," Goodwin said in a prepared statement."These jobs support and put food on the tables of many hard working West Virginians," Goodwin said. "Workers shouldn't be forced to earn their living in illegal, unsafe conditions. We will continue to use every tool in our arsenal to hold accountable those who willfully violate safety standards in the workplace." Massey's Aracoma Coal Co. subsidiary had already pleaded guilty in 2009 to 10 mine safety crimes, agreeing to pay a $2.5 million criminal fine as well as $1.7 million in civil penalties to resolve citations issued by the U.S. Mine Safety and Health Administration following the fire. Also, the Aracoma probe resulted in another foreman, David R. Runyon, pleading guilty to not conducting required evacuation drills and paying a $1,000 fine.But a lawyer for the Bragg and Hatfield families issued a strongly worded statement Thursday afternoon that repeated the families' previous criticism of the government's decision not to try to prosecute anyone further up the Massey corporate ladder."U.S. Attorney Goodwin must tell Congress now -- while it's listening and before we have even more widows of dead miners -- why the current law is insufficient to pursue all persons responsible for widows of dead miners -- why the current law is insufficient to pursue all persons responsible for such blatantly criminal and deadly conditions," said Bruce Stanley, the families' attorney.During the Jan. 19, 2006, fire, a crew of miners ran into thick, black smoke in their primary escape tunnel and had to try to find another way out of the mine. Two workers, Bragg and Hatfield, became separated from the group, got lost and eventually succumbed to the smoke. MSHA investigators cited a variety of major safety violations that led to the fire, including "prolonged operation" of a misaligned conveyor belt and allowing large spills of combustible coal dust and grease to build up on the belt.But the criminal charges Aracoma pleaded guilty to focused on violations that hampered miners trying to evacuate the mine after the fire had started, and prosecutors said that Runyon's case also did not directly involve the circumstances related to the fire.The charges filed against four more foremen on Thursday also focused on the Aracoma Mine's failure to conduct proper escapeway drills. While the charges filed Thursday did not blame the deaths on that inaction, one of the men charged -- Plumley -- was the foreman on the mine section where Bragg and Hatfield worked.In a statement issued Thursday, MSHA chief Joe Main said, "Mine managers who shirk their responsibility for ensuring the safety of their miners will be held accountable using all available sanctions under the Mine Act."Massey issued its own statement saying the company "takes the requirement to conduct escapeway drills seriously and will monitor this situation closely."We expect all of our miners to follow state and federal laws a swell as company policies, which are often more stringent," Massey said. "At the same time, we must recognize that the miners who have been charged have due process rights and are presumed innocent until proven guilty." Reach Ken Ward Jr. at email@example.com or 304-348-1702. Story Share Story Share Trending Now 1 Police seek car driven by woman found dead in Kanawha River 2 Teen pleads guilty to involuntary manslaughter in Oakes Field shooting 3 Facebook founder visits Cabin Creek Health Systems 4 Man allegedly cuts father in Rand over argument about sandwich 5 $115M project for WV Toyota plant to start in 2020 Hurricane Independence Day events set for Saturday Previous Story Union to take 'strike vote' on latest Alcan offer Next Story


text:
"Fast Food - A wise guy named Bobby sells "a million cheese burgers a year" at his burger joint with the help of his night manager (Joey), his goons (Frankie the Mop, Freddie Ammonia), and assorted industry specialists. The wild Scorsese spoof reveals the inner workings of the business as the goodfellas rule their drive-thru with an iron fist. Eventually, of course, they "f--- it all up."
As Seen On
Please visit Blogpire Productions for all advertising and other info.


text:
100% Chances are at least one of your grandparents smoked... amirite?
100% Putting words to good use is better than putting them to bad use.
100% I don't know hun, maybe it has something to do with the Nazi flag right behind you?
100% You can not be happy until you are willing to be what you are.
89% You are too smart to be taken in by the media... amirite?
100% You can't make anyone love you. You just have to reveal who you are and take your chances.
100% Understanding happens on the way to wisdom.
86% For want of a nail, a shoe was lost. For want of a shoe a horse was lost. For want...
100% If they can make penicillin out of mouldy bread, they can sure make something out of you.
100% I don't know hun, maybe it has something to do with the Nazi flag right behind you?
100% Walking in my shoes.
100% Chances are at least one of your grandparents smoked... amirite?
When was the last time someone asked you to come, hither.
73% My definition of "very fine people" and "sons of bitches" is not that...
86% A great golfer but you never liked Tiger Woods the person... amirite?
100% Spy gadgets, weapons, blow up **** dolls, and other things the CIA has funded. After...
100% Weekend is almost here, here is some relaxing music for you to enjoy
100% Apple should run the country. //For a complaint...all you have to do is phone...
Please tell me, when you heard the man in the back say "everyone attack," did...
100% **Always look when your skin tickles...you never know what insect crawled out from...
🌱 A study found that two hours of silence per day prompts cell development in the...
All you racebaiting bastards,tell me,What has happened since?
Amirite is the premier opinion-based social network where people from all around the world discover, debate and discuss today's hottest issues. Share your perspective to the world and interact with like-minded individuals on breaking news, hot topics and controversial issues now!
With that many angles, the discussions on Amirite will open your eyes to a panoramic view of your world that you won't get anywhere else, allowing you to see the big picture and discuss it.
Every opinion matters on Amirite.
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text:
Porta Chair
Summer Special: $5 shipping within Continental US
Turn ANY Chair into a highchair with Porta Chair!
Great for travel, dining out, or when simply visiting a friend's house, the Porta Chair goes where you go because it's compact, lightweight and small enough to fit in the bottom of a baby bag or stroller.
We've paid particular attention to the details in designing this product. All of the straps are fully adjustable for maximum safety and the soft cushioning will keep your child comfortable. We've also added a convenient cord at the bottom so you can neatly fold and carry the Porta Chair when not in use.
The Porta Chair is available in four colors – Slate (grey), Red, Avocado Damask, and Black and White Damask.
Retail price $49.50 USD.


text:
Matt Seay got a lot out of his four years at the University of Colorado-Colorado Springs and the first thing he did when he graduated and got a job was to give something back.
Seay, now a fiscal analyst for Lockheed Martin, is one of 1,100 students to have received need-based scholarships at UCCS in the past 11 years — all courtesy of the Bruce & Anne Shepard Reach Your Peak Scholarship Program.
Bruce Shepard, a longtime local developer, began the program to allow under-privileged students a chance. Other local donors have joined in, but the program involves no public money whatsoever.
On Wednesday, graduates and current students in the program gathered downtown and Seay got his chance to thank Shepard personally and publicly.
"What you do is nothing short of amazing," Seay told Shepard from a podium. Recalling his encounter with the program's committee four years ago, Seay said, "I was nervous for the interview. I knew if I didn't get the scholarship I would have a hard time getting through."
From tiny Eads in Eastern Colorado, Seay's graduating class in high school had only 17 members. He had no connections here and couldn't afford college.
The scholarship panel members obviously liked what they saw. Last year Seay graduated summa cum laude with a 3.98 grade point average.
As soon as he got a job, he mailed a check for $100. He wrote a letter to Shepard, saying "I worked hard, and because of your help, I succeeded.....I will be giving back to this program for many years to come."
Shepard came from humble beginnings. He attended Colorado College for six weeks before dropping out and joked, "I wasn't there long enough to fail."
Shepard, now in his 80s, went on to develop the Village Seven neighborhood and became wealthy, but he never forgot where he came from, and he always knew some determined people just need a little help and they'll prove they're worth the investment.
"What we're doing is pretty unusual," Shepard said in a bit of an understatement. "If we didn't help them, they wouldn't get there, but they stay with it."
Local businessman Mike Suggs, who volunteered to help run the program and conduct interviews, said "We're looking for students who have a job, we're looking for students who are active in their communities. What I've been working on is trying to make the program long-lasting."
Transforming 100 lives a year is a pretty big deal, especially when the effort comes from the generosity of private citizens like Shepard. If UCCS had to depend on the state for funding, it wouldn't happen.
"There are things in life you just believe in," Seay said, "and this program is one of them."
Listen to Barry Noreen on KRDO NewsRadio 105.5 FM and 1240 AM at 6:35 a.m. on Fridays and follow him on Twitter and Facebook.


text: Politics 17 March 2010 Glam Media launches French website The US-based Glam Media, which owns the women's website glam.com, is launching its French operations Sign up for our weekly email * The pre-release version of the website glammedia.fr features articles, photos, videos and content on fashion, beauty, luxury and lifestyle from leading French publishers and bloggers. New general manager Jean-Pierre Levieux and chief marketing officer Orianne Garcia will lead the French operations. Leviuex had previously launched Microsoft's MSN portal in France in 1996, and Garcia founded the web mail company Caramail. Subscribe from just £1 per issue More


text:
New Report Examines Agency Rulemaking Activity at Mid-term Point of Obama Administration
-For Immediate Release-
September 20, 2010
Contact: Brian Gumm, (202) 683-4812, firstname.lastname@example.com
New Report Examines Agency Rulemaking Activity at
Mid-term Point of Obama Administration
WASHINGTON, Sept. 20, 2010—Some agencies under the Obama administration have energetically laid out a clear rulemaking agenda, while others have been stymied by a variety of factors, according to a new OMB Watch report. The report, The Obama Approach to Public Protection: Rulemaking, was released today and evaluates the regulatory activity of several environmental, worker safety, and consumer protection agencies within the federal government.
The Obama administration's rulemaking record reflects a philosophical change from the Bush administration: agencies are more proactive and clearly recognize government's responsibility to protect the public, the report says. At the same time, the administration has fallen short of the high expectations set for it, both in addressing public need through regulation and in changing the cumbersome rulemaking process.
The report asserts that the Obama administration has begun to restore agency resources and leadership. However, rebuilding the agencies will take years due to the toll of neglect stemming from eight years of an anti-regulatory philosophy.
Rick Melberth, Director of Regulatory Policy at OMB Watch, said, "OMB Watch felt it was important to evaluate the Obama administration's approach to public protections and the regulatory process at the mid-term point. We've seen real progress by this administration, and especially by the U.S. Environmental Protection Agency (EPA), in repairing some of the damage that was done during the Bush administration." For example, agencies like the EPA have addressed some of the "midnight regulations" finalized in the waning days of the previous administration.
Melberth added, "Other rulemaking bodies have gotten off to a slower start, including the Occupational Safety and Health Administration (OSHA) and the Food Safety and Inspection Service (FSIS), which have seen some successes but have also been plagued by delays in filling appointed leadership positions due to foot-dragging on nominations in the Senate."
Matt Madia, regulatory policy analyst at OMB Watch and lead author of the report, pointed out that a barrage of harsh attacks from the president's political opponents has also impeded the Obama administration's ability to protect the public. Madia said, "Conservatives and business leaders have been criticizing the Obama administration for rapidly expanding the regulatory state. This exaggeration and negative spin on the president's record obscures the complexity of rulemaking within agencies and ignores the basic premise that regulation is necessary to prevent crises and keep people safe."
The report also highlights unforeseen events that have disrupted the plans of several rulemaking agencies. "At times, especially in 2010, external events have wrested the administration's regulatory agenda from its control," the report says. It continues, "The BP oil spill disaster, the explosion at the Upper Big Branch mine, and the recall of millions of Toyota vehicles, among other events, have consumed agency resources and attention. The events themselves color the administration's reputation while preventing agencies from fully crafting a record of their choosing."
The Obama Approach to Public Protection: Rulemaking is the first in a series of three reports designed to gauge the Obama administration's commitment to implementing effective public protections and reforming the federal regulatory process to make it more transparent, accountable, and responsive to the needs of the American people.
The report is available in PDF and browser-based e-book formats at http://www.ombwatch.org/obamamidtermrulemakingreport.
# # #
OMB Watch is a nonprofit research and advocacy organization dedicated to promoting government accountability, citizen participation in public policy decisions, and the use of fiscal and regulatory policy to serve the public interest. Find OMB Watch on Facebook and Twitter.


text:
How can you stop mold in the tracks? Worry about indoor contact with mold has grown through the years because the public is becoming conscious that contact with mold may cause a number of health effects and symptoms, including allergy symptoms. Water Damage Boca Raton can prevent harm to your house and furnishings help you save money and steer clear of potential health issues by controlling moisture and eliminating mold growth.
• The answer to preventing molds of all types, including black mold is moisture control
• If you've got a flood, it's important to properly dry water-damaged areas and items within 24-48 hours to avoid mold growth.
• If mold turns into a condition in your house or commercial space, Water Damage Boca Raton will remediate the mold promptly within IICRC guidelines.
Guaranteed - WATER DAMAGE Boca Raton provides the very indepth warranty in the market. Our warranty is superior within the following ways:
• The only warranty that's based on our 100% rate of success - no warranty claims are essential.
• The only warranty in the market that isn't capped through the price of work performed so they cover actual damage.
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Not all the companies are identical -
For those who have received an estimate from the company which has done the following, give WATER DAMAGE Boca Raton a phone call and go through the difference:
• Perform their very own pre- and/or post-remediation quality of air testing (a significant and frowned upon conflict of great interest).
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• Performs work without establishing containments (critical enclosures) vital towards the safety of ones own.
• Use encapsulates that only mask or hides the issue instead of addressing the main from the issue right from the start.
• Use harmful biocides or any other toxic chemicals which may be bad for your loved ones or building occupants.
You did a wonderful job and I would recommend your company and services to anyone. Your responded to our problem quickly and worked steadily until the job was completed. All work was very satisfactory, your employee was very professional and knowledgeable of the work that had to be done and accomplished it efficiently. I was happy with all of the work. You did a very professional job and we both appreciate that.- Harris K.


text:
Washington (Dec. 21)
The Senate today adjourned until January 10 without taking any action on the two resolutions approved by the Senate Foreign Relations Committee yesterday recommending the establishment of a special U.S. commission to deal with the question of rescuing the Jews of Europe and urging that the State Department cooperate with the British, Swiss and Swedish Governments in supplying food immediately to the starving populations of occupied territories.
The Senate Foreign Relations Committee held no hearings on the bill which suggested the Establishment of a U.S. Commission for saving Jews and to which it gave unanimous approval. After discussion, it amended the resolution to urge the creation of a commission to formulated and effectuates "plans," rather than "a plan" as the original bill suggested, of immediate action to save the surviving Jews of Europe. The House Foreign Affairs Committee has been holding open hearings on identical bills. No action will be taken before Congress convenes.
Sen. Gillette, the "father" of the bill, inserted in the Congressional Record a telegram received by the Senate Foreign Relations Committee from seven prominent clergymen supporting the establishment of a "special governmental commission to find ways and means to save the surviving Jewish people of Europe." They said, "We cannot approach Christmastide without declaring that too many of us have been wanting in the will to rescue these suffering people. " They urged that " no possible sanctuary be closed, whether in America or elsewhere, " Signers of the telegram were Rt. Reverend William T. Manning, Bishop of New York, Protestant Episcopal Church; Archbishop Athenagoras, Greek Orthodox Archdiocese of North and South America; Dr. Henry Sloan Coffin, Moderator of the General Assembly, Presbyterian Church, and President of the Union Theological Seminary, Bishop William J. McConnell, resident Bishop of the Methodist Church; Rt. Reverend Thomas J. Heistand, Protestant Episcopal Theological Church, Cambridge, Mass; and Dr. Russell Stafford, Minister of Old South Church, Boston.
Secretary of the Interior Harold L. Ickes has accepted the honorary chairmanship of the Washington chapter of the Emergency Committee to Save the Jewish People of Europe, according to an announcement made today. In his letter of acceptance, Mr. Ickes said "As one of the many millions of free Americans who have been infuriated by the savage brutality of the Nazis, I only hope that the Committee may contribute in a real way to the saving of as many as possible from the fury of Hitler and his hosts."


text:
Age-Related Changes in Body Composition
|Tracking Information
|First Received Date ICMJE
|January 24, 2012
|Last Updated Date
|June 30, 2017
|Start Date ICMJE
|January 2, 2012
|Primary Completion Date
|Not Provided
|Current Primary Outcome Measures ICMJE
|Not Provided
|Original Primary Outcome Measures ICMJE
|Not Provided
|Change History
|Complete list of historical versions of study NCT01517113 on ClinicalTrials.gov Archive Site
|Current Secondary Outcome Measures ICMJE
|Not Provided
|Original Secondary Outcome Measures ICMJE
|Not Provided
|Current Other Outcome Measures ICMJE
|Not Provided
|Original Other Outcome Measures ICMJE
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|Age-Related Changes in Body Composition
|Official Title ICMJE
|Age-Associated Changes in Regional Adiposity and Novel Cardiovascular Risk Factors
|Brief Summary
- Advancing age is associated with greater risk of heart disease. High blood pressure and hardening of the arteries also have more complications with age. Studies suggest that age-related inflammation may affect fatty tissue in the body. If this fat develops in the muscles or around the heart, it may increase risks of heart disease. Researchers will study body composition in older adults to see if age-related changes in body fat are related to higher risks of heart disease.
- To study the relationship between fat deposits and aging, and greater risks of heart disease.
|Detailed Description
Advancing age is associated with an increasing prevalence, incidence, and complications of cardiovascular diseases, particularly hypertension and atherosclerosis. The reasons why age is associated with increased susceptibility to cardiovascular diseases are not understood but recent literature suggests that systemic inflammation, by affecting endothelial function, vascular stiffening, diastolic dysfunction and insulin resistance may be an important contributing cause. Aging is also associated with substantial changes in body composition, primarily an increase in fat mass and a decline in lean body mass. Studies in animal models and in humans have shown that the adipose tissue is an important source of pro-inflammatory mediators and suggested that changes in body composition may be the primary cause of the pro-inflammatory state of aging. A number of gene expression studies in animal models show that genes of several pro-inflammatory cytokines are over-expressed with aging, especially in the adipose tissue. The overproduction of pro-inflammatory cytokines have important systemic effects, including (1) endothelial dysfunction, one of the earliest features of atherosclerosis; (2) vascular stiffening, the primary etiology for isolated systolic hypertension in the elderly; and (3) insulin resistance, the principal metabolic abnormality associated with cardiovascular risk. Fat infiltration in the liver also promotes chronic inflammation both directly and by inducing apoptosis of hepatocytes with consequent inflammatory response and deterioration of liver function.
Limited data exists suggesting that deposition of adipose tissue in specific districts but not in others is associated with high circulating levels of pro-inflammatory markers. For example, in humans central adiposity, including fat accumulation surrounding the heart, and fat infiltration in the muscle, opposed to subcutaneous adiposity seems to be particularly pro-inflammatory. However, this information comes from small studies, or studies limited to a very narrow age-range. In addition, the assessment of regional adiposity was mostly based on anthropometrics. Indeed, non-invasive methodology for the assessment of regional lipid deposition profiles has become available only recently.
We propose to complement the BLSA population with a group of individuals with established CAD because the inclusion of this group may help to determine whether, and if so the extent to which, the expected relationships between body adiposity, inflammation, endothelial dysfunction, arterial stiffness and insulin resistance are different in healthy individuals compared to age-matched individuals with clinically overt vascular disease.
As a side hypothesis, we will also verify whether changes in Testosterone with age are associated with changes in regional fat accumulation. To test this hypothesis we will measure total, free and biovailable Testosterone in all participants.
|Study Type ICMJE
|Study Design ICMJE
|Time Perspective: Prospective
|Target Follow-Up Duration
|Not Provided
|Not Provided
|Sampling Method
|Not Provided
|Study Population
|Not Provided
|Condition ICMJE
|Intervention ICMJE
|Not Provided
|Study Groups/Cohorts
|Not Provided
|Publications *
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Estimated Enrollment ICMJE
|Completion Date
|Not Provided
|Primary Completion Date
|Not Provided
|Eligibility Criteria ICMJE
In addition, for CAD participants (Group B):
In addition, for CAD participants in whom arterial and hepatic vein inflammatory mediators will be obtained:
- Scheduled for clinically indicated right or left heart catheterization, no contraindication for the procedure, and consented to the research procedure.
Exclusion criteria
In addition, for BLSA participants:
- Known coronary artery disease by prior history, examination, or resting or stress electrocardiogram testing.
In addition, for CAD participants undergoing arterial and hepatic vein inflammatory mediator sampling:
|50 Years to 90 Years (Adult, Senior)
|Accepts Healthy Volunteers
|Contacts ICMJE
|Contact information is only displayed when the study is recruiting subjects
|Listed Location Countries ICMJE
|United States
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
|Has Data Monitoring Committee
|Not Provided
|U.S. FDA-regulated Product
|Not Provided
|IPD Sharing Statement
|Not Provided
|Responsible Party
|National Institutes of Health Clinical Center (CC) ( National Institute on Aging (NIA) )
|Study Sponsor ICMJE
|National Institute on Aging (NIA)
|Collaborators ICMJE
|Not Provided
|Investigators ICMJE
|PRS Account
|National Institutes of Health Clinical Center (CC)
|Verification Date
|October 20, 2016
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP


text:
Mistress of the Sea Hardback
by Jenny Barden
Plymouth 1570; Ellyn Cooksley fears for her elderly father's health when he declares his intention to sail with Drake on an expedition he has been backing.
Already yearning for escape from the loveless marriage planned for her, Ellyn boards the expedition ship as a stowaway.
Also aboard the Swan is Will Doonan, Ellyn's charming but socially inferior neighbour.
Will has courted Ellyn playfully without any real hope of winning her, but when she is discovered aboard ship, dressed in the garb of a cabin boy, he is furious.
To Will's mind, Drake's secret plot to attack the Spanish bullion supply in the New World is a means to the kind of wealth with which he might win a girl like Ellyn, but first and foremost it is an opportunity to avenge his brother Kit, taken hostage and likely tortured to death by the Spanish.
For the sake of the mission he supports Drake's plan to abandon Ellyn and her father on an island in the Caribbean until their mission is completed.
But will love prove more important than revenge or gold?Mistress of the Sea is an epic romantic adventure set against the backdrop of Francis Drake's first great enterprise - the attack on the Spanish 'Silver Train' on the isthmus of Panama
- Format: Hardback
- Pages: 416 pages
- Publisher: Ebury Publishing
- Publication Date: 30/08/2012
- Category: Historical adventure
Other Formats
- Paperback from £6.55
- EPUB from £3.99
Free Home Delivery
on all orders
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Also by Jenny Barden | View all


text:
If David Mounteer sold secrets of celebrities he'd probably make a pretty penny, but A-listers, B-listers, film executives and partygoers passing through his hotel don't have to worry: Mounteer knows there's currency in keeping things hush.
The Thompson Toronto hotel consistently tops lists of the hotspots during the Toronto International Film Festival. For weeks, the 45-year-old general manager has been prepping his staff for the glitzy affair, which runs Sept. 5-15.
If the hype is right, this year's festival won't be short of any crowd-drawing celebs. Those reportedly attending? Brad Pitt, Meryl Streep, Colin Firth and Julia Roberts. Alcohol inventory up. Security quadrupled. Mounteer and his team are ready for "star-filled, business-filled parade of deals and parties," he says.
You've been involved with TIFF through the hotel industry for a few a years now, who are some of the biggest stars you've taken care of?
Oh boy, am I allowed to talk about this? You create personal relationships with people. The relationships are built over time. It's a small industry and everyone knows each other so I would hesitate to say who I've dealt with in the past.
TIFF is depicted as a brew of celebrities, parties and deal-making, how does your hotel fit into that bigger picture, and how do you prepare for it?
People in the hotel business, myself included, this is what we live for. These kinds of challenges, this monumental wall of business and craziness, is exactly what we crave. If we wanted stable businesses we would go into different areas. The hotel business is all about people, it's all about relationships. TIFF is where all of this comes together. It's a huge task.
In what specific ways do you prepare for TIFF?
We multiply our beverage orders by at least four times ... We have a specific night where we have four different studios doing parties on all levels of the hotel, from the rooftop to our nightclub to the entire main floor, which is our lobby and our restaurants. They're not meant to combine. In the end, these will combine.
Are there other examples of that?
A new thing for me this year is we've had to bring in some butlers for some of our guests that request that level of service, that 24-hour presence ... We're doing weird things, for instance, our loading dock, which is normally a forgotten spot, we're beautifying our loading dock because we know stars will want to park their cars, get in and out quickly. We're painting and putting plants in the loading dock. Once it's painted it's going to be a pretty stunning little loading dock.
How important is it for the hotel to have stars stay there and how do you balance wanting them, while also charging them high rates?
It is. It's very important. It's all about image. The stars add to the glamour... During TIFF, it's understood that all the hotels in the city -- especially luxury hotels -- are in high, high demand. Especially the suites. The stars do pay. (During TIFF, a suite costs between $1,000 to $3,000 a night.) It's in our best interest for them to be happy, to return, to refer. We do focus on them quite a bit. But we focus on everyone.
How do you recruit celebrities and charge at the same time, and does that create a tension?
We recruit studios. We deal with studios -- and occasionally we deal directly with an agent -- that are working with a film and doing PR or junkets in the city. With each studio comes a variety of talent ... Everybody thinks celebrities get everything for free. We charge celebrities for our services because it's part of our principle and our business model.
Any surprising requests by celebrities over the years?
One of our most shocking requests [when I worked at The Hazelton Hotel] started off innocently enough with a request for a large number of bottles of champagne. To our surprise this was not for a wild TIFF party, but rather for a champagne bath for two. One guest was very specific on their demands for their TIFF stay, right down to the dimensions of the ice cubes for the drinks. We had a team member shave them down to perfectly symmetrical cubes.
A bit unrelated to TIFF, but how important is a destination-style restaurant to a hotel? Is it mainly for the guests, for diners, for catering parties?
It's more about building the vibe and energy of a building in the sense that you may get a few rooms that book, you may get some people that come from other hotels that go to your destination restaurant, but it's really about building energy ... This restaurant has to a part of that energy that flows throughout the building. It would be less about putting heads in beds. The restaurant is more about creating energy within the building.
Especially during TIFF, how important is the doorman job at the hotel?
It's extremely important. We call ourselves a New York-style hotel, but the one thing that we don't want to emulate from New York is the snotty doorman. Here our doormen are warm, friendly guys, good looking guys, that really welcome the guests.
*This interview has been condensed and edited


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Paul Garvey
Tiger Airways has confirmed it will open a third base, at Avalon Airport in Victoria, later this year. It will also increase its Australian fleet with two new A320 aircraft, taking its total number of aircraft in Australia to 11. Avalon Airport will expand its facilities to cater for the additional flights.
Michael Smith
Travel agent
Communications and metal detection group
Michael Smith
Scandinavian Resources will begin trading on the Australian Securities Exchange at noon tomorrow.
Staff reporter
Staff reporter
Luke Forrestal
The Australian Financial Review


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Helen E. Carnahan, 95, died Tuesday. Cassaday-Turkle-Christian.
Florence Coco, 84, of Mt. Vernon, died Wednesday. Sharer-Stirling-Skivolocke.
Patricia L. Rankin, 79, died Sunday. Sharer-Stirling-Skivolocke.
Geraldine L. Stitt, 78, of Massillon, died Wednesday. Reed, North Canton.
* * *
Death notices are printed as a free service for our readers. Information regarding paid obituaries can be obtained from your local funeral home.


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Welcome to the Blogosphere: Written Description
Watch out, Patently O, there's a new patent law blog on the block! Lisa Larrimore Ouellette's Written Description does an extraordinary job of covering debates in patent law and proposals for doctrinal improvement. Patent law scholarship has really flourished over the past decade, and it is great to see someone as well-informed and insightful as Lisa commenting on the issues.


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It only takes a minute to get started. Fill out our uncomplicated sign up form and login to the site.
This step is optional but will seriously raise your chances of getting interest from other over 40s members on the site. Type a little about yourself, your interests and upload a nice photo of yourself.
Use our website's advanced search to pinpoint over 40s members who match your needs. Or just leaf through listings and pinpoint people that you like.
Identified someone who appeals to you? Send a message to them or just a wink and take it from there. With a little luck you'll be on your way to a lifetime of happiness.
It's quick and simple


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Read more from Larry Perry here and in the Today's World of Audits archive.
Since the AICPA's Financial Reporting Framework for Small- to Medium-sized Entities (FRF for SMEs) and some other financial reporting frameworks use the accrual basis of accounting, matching costs of goods sold with sales revenues in the period of sale is a basic principle. Determining inventory quantities and values is, therefore, an important management responsibility for most frameworks, including the FRF for SMEs. As described in the following paragraphs there is, however, a difference from U.S. GAAP when applying the lower of cost or market principle to inventory valuations.
U.S. GAAPRequirements
Inventories are valued under FIFO, LIFO, average cost, specific identification, or retail methods at the lower of cost or market. Inventory costs are not permitted to exceed the ceiling of net realizable value (selling price less costs of completion and disposal) or be less than the floor of net realizable value (ceiling of net realizable value less a normal profit margin).
FRF for SMEsRequirements
Inventories are valued at the lower of cost or the ceiling of net realizable value determined under the FIFO, LIFO, average cost, specific identification, or retail methods (selling price less estimated costs of completion and disposal). General disclosures are:
- Accounting policies and costing method.
- Carrying amounts of inventories in total and by appropriate classifications, e.g., raw materials, work-in-progress, finished goods, merchandise, supplies.
- Costs of goods sold for periods presented.
- Unusual or material losses resulting from costing methods.
- Material purchase commitments and any expected loss when the purchase price exceeds market value.
- Any interest costs capitalized in inventories.
Learning how to audit inventories for any framework centers on inventory observations, pricing and clerical tests, and learning to "what extent" auditing procedures should be applied. Somewhat different than with other major audit areas, entities that account for inventories using either the physical or perpetual inventory methods experience most of their risks of material misstatement in counting, pricing, and compiling the inventory components.
Similar to other audit areas, the amount of audit work for inventories depends on the risk of material misstatement (RMM) evaluations at both the financial statement and classification (assertion) levels. Based on an understanding of a client's industry and its business (particularly its operations), the nature of its inventories, and its inventory accounting method (physical or perpetual), the auditor identifies the risks of material misstatement and designs auditing procedures to gather evidence to evaluate the financial statement assertions for inventories.
The Relevant Auditing Standards
Specific Auditing Standards for inventory are published in the AICPA Professional Standards, AU Section 331. Some of the key issues in this section include:
- Inventory observation is a generally accepted auditing procedure (before the McKesson Robbins case inventories could be confirmed by auditors).
- For physical counts of inventory, the auditor must usually be present at the time of the count to observe count procedures, make test counts, and inquire about potential risks of material misstatement.
- For accurate perpetual inventory records, the auditor's observation procedures may be performed at periods during or after the year being audited.
- For statistical methods of sampling inventory, the auditor must be satisfied that the client's methods produce reliable results that are substantially the same as a count of all items. The auditor must be present for representative counts and must evaluate the sampling plan and its application to determine that results are reasonable and statistically valid.
- For inventories held in public warehouses, quantities may be confirmed, but additional procedures are usually necessary. Examples of such additional procedures are obtaining an audit report on the warehouseman's internal control or applying appropriate procedures at the warehouse to determine confirmed information is reliable. Other procedures such as observing physical counts of the goods and testing the owner's procedures for investigating and evaluating the warehouseman's performance may be necessary in some cases if practical and reasonable.
In Part 2 of this article, the impact of risk of material misstatement on inventories auditing procedures will be discussed. For live and on-demand webcasts on this and other subjects, click on the applicable box on the left side of my home page, www.cpafirmsupport.com. Be sure to register on my website to receive a 20 percent discount on all webcast products purchased through the site portal.


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Here's what's happening at The Star. For media requests please submit your media inquiry and one of our representatives will be in touch with you.
Casino Press Releases
Casino Related Press Releases
Press Releases
Support Hometown Hero Holly Holm at The Stage during UFC 196
The Pueblo of Santa Ana, N.M. – March 4, 2016
In honor of hometown hero Holly Holm's first Ultimate Fighting Championship (UFC) title defense, Santa Ana Star Casino will host a viewing party for UFC 196. The viewing party will be held at The Stage on Saturday, March 5. UFC superstar Carlos Condit will host the viewing party, featuring a co-main event with the Women's Bantamweight Title Championship between Holly Holm and Miesha Tate and a welterweight bout between Lightweight Champion Conor McGregor and Nate Diaz.


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1. The style or pin, which by its shadow, shows the hour of the day. It is usually set parallel to the earth's axis.
2. (Science: astronomy) a style or column erected perpendicularly to the horizon, formerly used in astronomocal observations. Its principal use was to find the altitude of the sun by measuring the length of its shadow.
3. (Science: geometry) The space included between the boundary lines of two similar parallelograms, the one within the other, with an angle in common; as, the gnomon bcdefg of the parallelograms ac and af. The parallelogram bf is the complement of the parallelogram df.
4. The index of the hour circle of a globe.
Origin: L. Gnomon, gr. One that knows, the index of a sundial. See Gnome.
Please contribute to this project, if you have more information about this term feel free to edit this page.


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This is a classic case of "so funny because it's so almost true that if you didn't laugh you would stab yourself in the eye but that's a bad idea because all the hospitals are placebo hospitals and placebos don't work so well on stab wounds."
From my new best friend, Newsbiscuit: Jeremy Hunt to open world's first placebo hospital.
Britain's first hospital built entirely on the power of suggestion is to be opened next week as a cost-effective solution to the rising price of healthcare. The Royal London Placebo is totally fabricated, offers no actual treatments and will be manned entirely by extras from TV shows such as Casualty and Holby City.
'Each doctor will have a nice white coat, a plastic stethoscope and a range of brightly coloured sugar pills,' explained Health Secretary Jeremy Hunt. 'No expense has been spared,' he said, 'except the expense of building an actual hospital with trained staff and equipment.'
Pilot studies show that half the patients who attended a placebo hospital imagined they were better and went home; meanwhile the other half had a failure of imagination and died on the spot. 'Either way it's a win-win,' said Hunt.
Read the whole thing. It's very funny.


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Schoenfeld Asphalt Late Model Crossover Headers - 1-3/4" Diamter Tubes - 3-1/2" Diameter x 8" Length Collectors - Standard SB Chevy
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Detail Information
- Advancing workplace health protection and promotion for an aging workforceRonald R Loeppke
U S Preventive Medicine, Brentwood, NJ 37027, USA
J Occup Environ Med 55:500-6. 2013..To explore issues related to the aging workforce, including barriers to integrating health protection and promotion programs, and provide recommendations for best practices to maximize contributions by aging workers...
- The association of technology in a workplace wellness program with health risk factor reductionRon Loeppke
US Preventive Medicine, Inc, Brentwood, TN, USA
J Occup Environ Med 55:259-64. 2013..Determine whether there is a relationship between level of engagement in workplace wellness programs and population/individual health risk reductions...


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Alvin of Holy Bullies and Headless Monsters on Hillary's gay/trans speech to to the UN, and Jim Downs' criticism of it.
Gays should never fear the desperation of those who choose to be our enemies. But we should fight them head on. And Downs' column reveals a sad fact, not only about the gay community, but many of those we anoint as our leaders. Unlike our brothers and sisters in foreign countries, we have the means to fight back, but we rarely do.
And by fighting back, I don't mean solely street protests or acts of useless spontaneity fueled by rage. I mean a steady and consistent stream of calling out religious right lies.
[Hillary] told us that we are human beings. [Downs] is telling us that we should be cowards.


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Years ago I was dealing with a computer company about a problem, and got to know many of their employees in India so well that I felt like inviting them to drop by for a visit if they were ever in the States.
So I can identify with Gladys Ford's story:
"While trying to make an upload to Amazon, I always asked the person on the help line, 'Where do you live?'
"During this two-week-long ordeal, I spoke to customer service reps in Cape Town, South Africa; England; Uruguay; Costa Rica; and the Philippines.
"When giving my address to the last rep, I started spelling 'Denham Springs' for her.
"She said there was no need to spell it, because she lived in Denham Springs, too.
"Her subdivision is three miles from my house. Amazing world."
Gracias, Felipe
Just heard from Phil "Felipe" Cangelosi, who's been spending time in Mazatlán, Mexico.
He offers these "little-known observations" about his second home:
"Uno: Cinco de Mayo isn't nearly as popular in Mexico as it is in Baton Rouge.
"Dos: In Mexico your last name is actually your middle name. Mucho confusing.
"Tres: The finest tequila we sell here in the States is not considered very good.
"Quatro: Mexico City is simply 'Mexico.' Drop the word 'city.'
"Cinco: Sushi is incredibly popular among the locals. It is, however, served with tortilla chips and chili peppers."
Black salve revisited
Spike Barras was the first of many, many contributors to identify that stinky black ointment mentioned by a nostalgic reader as ichthammol, also called ichthyol.
It's ammonium bituminosulfonate, sold under a variety of brand names to treat acne, eczema, psoriasis and other skin diseases, and as a "drawing salve" to help remove splinters.
Ross DeNicola, DDS, figures creosote was one of the ingredients, which would account for its aroma. But George E. McLean, of Metairie, says it's fish oil that makes it stink.
Lionel Jardell says, "We have a tube of this magic medicine in our house that is so old one cannot read the label. Works great on the grandchildren, but grandson Emerson says it stinks."
Adrain E. Johnson Jr., professor emeritus in the LSU Department of Chemical Engineering, says, "My wife, Betty, and I used this ointment throughout our childhood, and continued using it for many years after we married in 1949, until antibiotic ointments became available.
"The antibiotic in today's ointments can, of course, help prevent infection from a cut, which is not a 'minor skin irritation.'"
And John Torbert says of the ointment, "My grandmother said it would do anything but raise the dead."
The right way
We're still getting comments on ways to sing, or not sing, 'The Star-Spangled Banner':
Elliot Bourgeois says, "Wayne Messmer sings the national anthem, like it should be sung, at most major Chicago sporting events. Watch the opening of Cubs games on WGN-TV."
Thank-you notes
Past Commandant Richard Ulrich says the Choctaw Detachment of the Marine Corps League thanks "everyone for their donation to our Rose Day event at the Wal-Mart on O'Neal Lane."
Backyard rainbow
"Bird Nerd" says, "My backyard in St. Gabriel has become a gathering place for some exquisite birds: brilliant blue indigo buntings, rainbow-colored painted buntings and bright yellow American finches.
"Socially, they've blended right in with the existing year-round population of local birds — very multicultural. I feel like I've won the avian lottery!"
Worthy causes
The Fourth annual Red Bug Hill Challenge for Spina Bifida will be held Saturday in memory of Jordy Rourke, of Baton Rouge, who was born with spina bifida and died in 2008.
There will be cycling routes of 5, 20, 40 and 60 miles, a 5K trail run and one-mile fun run, "in the beautiful rolling hills near St. Francisville."
There will be lunch, music and a bicycle raffle. Go to http://www.redbughill.com, e-mail firstname.lastname@example.com or call Mike Rourke at (225) 937-5800.
Special People Dept.
- Charlie "Honey" Rihner, of the Gentilly neighborhood in New Orleans, celebrated his 103rd birthday Sunday at his annual Cinco de Mayo birthday party given by his family. He's a World War II veteran.
- Phyllis Sobers, of Flannery Oaks Guest House, celebrated her 92 birthday Sunday.
Thought for the Day
From Algie Petrere: "Before you open your mouth to speak, make sure it's an improvement on the silence."
Riding the Tide
"I think I need an LSU football fix," says Cindy Black Bouchie, of Pineville.
"The other day when you had an item titled 'Take that, Tide!' I was ready to get defensive about the laundry detergent, some of which is made at the P&G plant in Pineville.
"Then I saw it was a hilarious comment about Alabama's football team."
Write Smiley at email@example.com. He can also be reached by fax at (225) 388-0351 or mail at P.O. Box 588, Baton Rouge, LA 70821.


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Wind River Reservation Interpretive Plan; First one ever for a United States Indian Reservation
(Wind River Indian Reservation, Wyo.) – An Interpretive Plan for the Wind River Indian Reservation, the first ever done for a reservation in the United States, is now 90 percent complete. Work on the plan began in January 2009. The goal of planners is to have the document completed by this October.
"Why are we doing this?" asked Cheryl Hazlitt at a meeting of stakeholders Tuesday night in Riverton. "We are all defined by stories, we carry stories of our home, place, events and our ancestors. These stories surround us and impact our lives. They can move us forward, or hold us back depending on how we carry them. This story is about these tribes on this reservation." Hazlitt is the project manager and lead interpretive planner for the USDA Forest Service- Center for Design and Interpretation in Colorado, one of the partners in the effort.
The draft interpretive plan document is made up of 11 sections and represents the Tribes' important history and sites, from their point of view. The effort has been facilitated by the Wyoming State Historic Preservation Office, the Wyoming Office of Tourism and the Tribes of Wind River.
"This plan establishes a framework, a roadmap for future efforts and it represents a coordinated and unified approach to interpretation," Hazlitt said. "What we do when telling stories is to tell the truth. Not everyone likes to hear it, but that's how we get by it."
The overall theme of the interpretation is a strong statement, Hazlitt said. "The Eastern Shoshone and Northern Arapaho are resilient people who have sustained their traditions, environment, communities and cultural values in the face of land theft and cultural suppression."
Of the major 11 themes in the plan, each contains a number of sub sections, or stories to be told through interpretation. The plan spells out what non-native people should know about the Reservation, the people who live there, and their cultural heritage. The plan also indicates what Reservation residents should know and remember.
The draft plan proposes historical kiosks and information signage around important points of interest on the Reservation. The locations were chosen by Tribal representatives and interested parties at 18 meetings held last year and this. A total of 24 points of interest were selected.
Entrance portals are also proposed "to increase visibility from the roadway and makes the Reservation entrances very clear," according to the plan. At the present time, the signage consists of white on green metal signs produced by WYDOT and placed adjacent to highways. The major entrance portals could feature statuary at major locations with interpretive signage or informational kiosks around Reservation communities.
The draft plan can be reviewed by clicking here.


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Delight in the perfect combination of a delectable buffet breakfast and elegant accommodation for two with panoramic views of the Singapore city.
At The Ritz-Carlton, Millenia Singapore, guests will find themselves immersed in a canvas of views that is comprised of the hotel's renowned architecture, 4,200-piece museum quality art collection, and its iconic location in Marina Bay.
The hotel features an elevated Club Lounge experience on level 32, and world class dining options that include Colony and the One Michelin Star, Summer Pavilion. The Ritz-Carlton Spa is the first La Mer hotel partner spa in Asia Pacific.
Delight in the perfect combination of a delectable buffet breakfast and elegant accommodation for two with panoramic views of the Singapore city.
Celebrate the Mid-Autumn Festival with a selection of artisan snowskin mooncakes and traditional baked mooncakes. Enjoy a 15% privilege on all mooncake purchases with selected credit cards.
Newly open, discover the true nature of beauty as our therapists indulge you in a luxurious nail and feet pampering experience.
Perfect for a group pampering or celebration, relax with a La Mer facial, massage, and bespoke nail treatments with your friends before dining by our pool.
Turn your staycation into a timeless indulgence when you book into The Ritz Carlton, Millenia Singapore. Choose between complimentary buffet breakfast or a complimentary room upgrade.
Take your taste buds to new heights with our new tasting menu, specially created to celebrate earning a one Michelin star for a second consecutive year.
Our Ladies and Gentlemen are the key to the best our destination has to offer. Our carefully curated collection of local attractions and experiences help you customize the perfect vacation.