text:
Plasma Adiponectin Level and Sleep Structures in Children With Prader-Willi Syndrome
This study has been completed.
Samsung Medical Center
Information provided by:
Samsung Medical Center
ClinicalTrials.gov Identifier:
First received: January 18, 2012
Last updated: June 14, 2012
Last verified: June 2012
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
Context: Adiponectin is an adipose tissue-derived hormone with an insulin sensitizing effect, and has been related to obstructive sleep apnea syndrome. In addition, children with Prader-Willi syndrome (PWS) suffer from excessive daytime sleepiness and the abnormality of rapid eye movement (REM) sleep.
Objective: To determine if the sleep stages are related to the plasma levels of adiponectin, resistin, and RBP4 (retinol binding protein-4), and whether these relationships are influenced by age, obesity and insulin resistance.
|Prader-Willi Syndrome Obesity
|Study Type:
|Study Design:
|Observational Model: Case Control
Time Perspective: Prospective
|Official Title:
|Plasma Adiponectin Level and Sleep Structures in Children With Prader-Willi Syndrome
Resource links provided by NLM:
Genetics Home Reference related topics: Prader-Willi syndrome
MedlinePlus related topics: Prader-Willi SyndromeU.S. FDA Resources
Further study details as provided by Samsung Medical Center:
|Study Start Date:
|January 2007
|Study Completion Date:
|June 2007
This comparative study was carried out in 28 PWS children and 18 controls. The enrolled PWS children were volunteers out of a pool of approximately 100 PWS children followed at Samsung Medical Center [median age 8.0 years, interquartile range (7.0-10.5 years), BMI: median 24.2 kg/m2 (23.0-27.5 kg/m2)] and 18 obese healthy children [median age 9.0 years interquartile range (7.0-11.0 years), BMI: median 24.2 kg/m2 interquartile range (23.1-27.6 kg/m2)].
|Ages Eligible for Study:
|5 Years to 12 Years (Child)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Probability Sample
Study Population
The study population comprised 28 children with PWS and 18 controls. The enrolled children with PWS were volunteers from a pool of approximately 100 children with PWS followed up at the Samsung Medical Center. The controls were healthy children from several elementary and middle schools located in the southern areas of Seoul.
Inclusion Criteria:
- Prader Willi syndrome healthy children
Exclusion Criteria:
- history of seizure,
- mental or brain illness,
- adenoidectomy,
- tonsillectomy,
- craniofacial anomalies and any treatment at the time of the study.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01622751
Please refer to this study by its ClinicalTrials.gov identifier: NCT01622751
Sponsors and Collaborators
Samsung Medical Center
|Principal Investigator:
|Dong-Kyu Jin, M.D.
|Samsung Medical Center, Sungkyunkwan University School of Medicine
More Information
Keywords provided by Samsung Medical Center:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|ClinicalTrials.gov Identifier:
|NCT01622751 History of Changes
|Other Study ID Numbers:
|Study First Received:
|January 18, 2012
|Last Updated:
|June 14, 2012
Keywords provided by Samsung Medical Center:
REM sleep
Prader-Willi syndrome
Additional relevant MeSH terms:
Prader-Willi Syndrome
Pathologic Processes
Intellectual Disability
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn
Nutrition Disorders
ClinicalTrials.gov processed this record on September 21, 2017


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Fly Lines for St. Croix & Diamondback & Musky
I have a 10wt Diamondback Flawless. It has 10wt Little Tunny intermediate line on it & I recently learned the rod is underlined (& I thought it was just me!). I love this rod. When a different intermediate line was put on it, the rod loaded so much better with little line on the water! I will also purchase a 10wt St. Croix Legend Elite -probably freshwater vers.
My questions: 1) Any suggestions for intermediate line that will compliment both of these rods?
2) A friend and guide had 9wt Airflo 40+ 300 grain on his 10wt Croix (freshwater)and it casted v. well. I didn't get the chance to put this line on my Diamondback. Does anyone know how well this line will compliment the 10wt Diamondback? I also plan on purchasing sinking line. Any other recommendations would be welcome.
BTW, I fish muggy midwestern summer temps and also when the guides start to freeze up. Coiling line makes me batty.
Thanks, Twitch
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subset: commoncrawl


text:
Thank you, Deseret News, for your excellent editorial calling for the ratification of the Comprehensive Nuclear-Test-Ban Treaty ("Ratify test ban treaty," Sept. 30). During the 2010 legislative session, we sponsored a House Resolution urging Utah's senators to support the ratification of the CTBT.
Before the floor vote, our colleagues in the House offered impassioned speeches discussing the national security benefits of the CTBT, the continued safety and security of our nuclear weapons arsenal under the current scientific Stockpile Stewardship Program and the painful legacy left by the history of nuclear weapons testing in Nevada.
Following these favorable floor speeches from both Republicans and Democrats, the House voted unanimously to pass a resolution urging our senators to support the ratification of the CTBT. Once again, we would like to join our voices to that of the Deseret News in urging Sen. Orrin Hatch and Sen. Mike Lee to support the CTBT.
As former Sen. Jake Garn so powerfully wrote in his recent op-ed: "Now is the responsible time for the United States to ratify the Comprehensive Nuclear-Test Ban Treaty."
Rep. Jennifer Seelig, D-Salt Lake City
Rep. Ryan Wilcox, R-Ogden


text: Hey there- Selling a pair of nCode 95s in 5/8 grips. These are the regular 12 ouncers, not the lightweight team models. Racquets are in very nice shape, with just a few small nicks. One strung with PSD, other unstrung. $70.00 each exclusing shipping. Paypal only. Feel free to ask questions or request photos. Thanks! skraggle @ yahoo.com (remove spaces)


text:
Kornelius Adalbert von der Marwitz
Imperial Germany's
Supreme Command quickly recognized that cavalry units would
not be effective on the static Western Front and in the face of modern
military tactics and weaponry; so in December 1914, HKK2 was dissolved
and von der Marwitz was transferred to East Prussia to command the
newly organized 38th Reserve Corps. His February 1915 victory during
the Winter Masurian battle earned him the Pour
le Merite. In March, von der Marwitz and his army
corps were sent to Miskolcz, Hungary where the 38th
became known as the Beskidenkorps, named after the
Beskid mountain range in the Carpathians. The Austrians had just lost
the Przemysl Fortress and during the Easter season, von der Marwitz
assembled his troops at Mezö
Laborcz (German: Laborcza Tal) to fight
off the Russians as they attempted to cross into Hungary. In heavy snow
over the next few weeks, the Germans countered and fought the Russians
to a stalemate in the Wirawa Gorge
|Curriculum Vitae


text:
TALLAHASSEE — A Florida Panhandle teacher who registered students to vote but turned in their applications late may be fined for violating the state's new election law, which has drawn fire from critics who say it will suppress voting.
Secretary of State Kurt Browning asked Attorney General Pam Bondi to investigate and seek applicable fines in a letter Thursday.
Browning wrote that election officials in Santa Rosa County have documented 76 registration applications collected by the teacher that appear to have violated the law that went into effect this year.
It requires third parties to turn in applications to the county Supervisor of Elections Office within 48 hours of being collected. The old law had a 10-day deadline.
Each violation can result in a $50 fine, but no single individual or organization can be fined more than $1,000 in a year.
The letter says the unnamed Pace High School teacher has a history of violations.
"The circumstances of this case greatly concern me," Browning wrote.
He noted that the teacher reportedly said applications collected in April 2009 were not turned in until five months later because they were in her file cabinet over the summer break.
In 2008, one of her students was turned away from a polling place because she had not submitted his application before the registration books closed for that election, Browning wrote.
He added that the teacher registered with the state as a third-party voter registration organization in 2009 under the old law, which demonstrated an awareness of the law. Her registration, though, was canceled in August because she had not reregistered as required by the new law, he said.
Santa Rosa County superintendent Tim Wyrosdick did not return messages seeking comment that were left on his cell and home phone Friday night.
Browning spokesman Chris Cate said a teacher in New Smyrna Beach who also is suspected of violating the law likely will get only a warning because she has no prior violations.
As a result of that case's publicity, Democratic U.S. Sen. Bill Nelson urged Gov. Rick Scott in a letter to seek repeal or modification of the law.
"After this incident with the teacher, can anyone actually say we aren't taking a step backward in Florida when it comes to protecting one of our most fundamental rights?" Nelson wrote.
Cate said that teacher, Jill Cicciarelli, would have been in violation even of the previous 10-day requirement because she had let more than a month pass before turning in applications.
He noted that the fines were not changed by the new law.
More than two-dozen individuals and organizations have intervened in a federal court case opposing approval of four sections of the law, including the voter registration provision. They contend the law discriminates against minorities, students and the elderly.


text:
Chit chat with Hero Venkatesh - Tv9
Thu, Jun 04, 2015, 09:08 AM
Hero Venkatesh has gone into the mood of spirituality altogether and he is seeking one month time before starting the shooting for his next movie. Venkatesh has participated in a Filmfare event in Hyderabad yesterday. During the event, Venky told the media that his association with Filmfare is a long one and told that he always looked forward for the Filmfare event. Watch the video and listen to Venkatesh . . . .


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Troy, Michigan – Seco Tools LLC has released the results of its North American Carbide Recycling Program for 2013. The company collected and processed 125,919 lb (57,235kg) of used carbide tools. Of the total, 110,585 lb (50,265kg) were returned to Seco Tools AB for processing into grade powder. Over the life of the carbide recycling program, Seco Tools has returned an average of over 10,100 lb (4,100kg) of tools per month for recycling.
Partially in response to the program, this past August Seco Tools was named in Corp! magazine's list of "Michigan's Best and Brightest Sustainable Companies" for 2013. The honor reflects the company's active efforts to support sustainability and minimize its impact on the environment. "We scored particularly high in community outreach and the promotion of sustainable practices," said Kurt Nordlund, president of Seco Tools North America. "We are committed to sustainability and taking a leadership role on environmental initiatives. That is evident through programs like our Carbide Recycling Program."
In the program, Seco provides manufacturers with small, medium or large storage containers to place within their facilities. Small 1-pint containers hold approximately 11 lb (5kg) of carbide, medium 1-gallon containers hold approximately 50 lb (23kg), and the large 30-gallon drums accommodate approximately 2,000 lb (910kg). As tools reach the end of their useful life they are placed in the containers, which are then collected by Seco. Any carbide products from any manufacturer can be submitted, including carbide inserts, solid drills, solid end mills, wear parts and PCD/PCBN-tipped inserts. Manufacturers are paid at the market rate when the carbide is returned.
In addition to the environmental benefits of recycling, Seco's Carbide Recycling Program helps to address the growing global demand for tungsten, which comprises 75% of cemented carbide tools. Up to 95% of the material in a typical carbide insert can be reclaimed, helping to ensure the long-term sustainability of the metal cutting industry. Seco says recycling reduces related energy consumption by 35% and cuts CO2 emissions by 40%.
Manufacturers interested in participating in the Seco Tools Used Carbide Recycling Program can visit www.secotools.com/recycling for more information, or contact Vic Bruni at firstname.lastname@example.com.
Source: Seco Tools


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Create an Account - Increase your productivity, customize your experience, and engage in information you care about.
Unless otherwise noted and advertised, each Board of Commissioners meeting begins at 5:30 p.m. and is held in the Meeting Room at the Administration Building, 102 Town Hall Drive, Kill Devil Hills. Select the links below for packet information and approved minutes for each meeting.
Monday, January 9 Minutes
Tuesday, January 24 Minutes
Monday, February 13 Minutes
Monday, March 13 Minutes
Monday, April 10 Minutes
Wednesday, April 26 (Public Forum) Minutes
Monday, May 8 Minutes
Wednesday, May 31 Minutes
Monday, June 12 Minutes
Wednesday, June 28 Minutes
Monday, July 10 Minutes
Monday, August 14 Minutes
Monday, September 11
Monday, October 9
Wednesday, October 25 (Public Forum)
Wednesday, November 15
Monday, December 11
Videos of Board of Commissioners meetings can be viewed on the Town's YouTube page at
KDH YouTube Channel


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Magalie earrings in blue & silver
Swiss designer Maheva Ambresin spent most of her time in Paris, France, working in various ends of the fashion spectrum, including as a clothing designer, a graphic artist, and as an art director. After moving to NY she realized she couldn't find the exact earrings she was dreaming of, and decided to make them herself. A few prototypes back and a couple of overnight Instagram fans later, RUE Jewelry was born. Each piece is handcrafted, either sold as single or as deliberate mismatching pairs.
- Long pair of mismatching earrings
- Approx. length: 4" / 12cms
- Plated sterling silver, lapis lazuli blue beads
- Designed and handmade in Brooklyn, NY


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Research Topics
Genomes and Genes
Gene Symbol: H3
Description: histone cluster 2 H3 family member c
Alias: H3.2, H3/M, H3F2, H3FM, H3FN, histone H3.2, H3 histone family, member M, H3 histone, family 2, histone 2, H3c, histone H3/m, histone cluster 2, H3c
Species: human
Top Publications
Scientific Experts
Detail Information
- 14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activationStefan Winter
Max F Perutz Laboratories, Vienna Biocenter, Medical University of Vienna, Vienna, Austria
EMBO J 27:88-99. 2008Interphase phosphorylation of S10 at histone H3 is linked to transcriptional activation of a specific subset of mammalian genes like HDAC1. Recently, 14-3-3 proteins have been described as detectors for this phosphorylated histone H3 form...
- Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 geneP Shankaranarayanan
Eicosanoid Research Division, Department of Gynaecology, University Medical Centre Benjamin Franklin, Free University Berlin, D 12200 Berlin, Germany
J Biol Chem 276:42753-60. 2001..After 9-11 h, when histones become acetylated, STAT6 binding sites may be demasked so that the phosphorylated and acetylated transcription factor can bind to activate gene transcription...
- DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNASteen K T Ooi
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Nature 448:714-7. 2007..Peptide interaction assays showed that DNMT3L specifically interacts with the extreme amino terminus of histone H3; this interaction was strongly inhibited by methylation at lysine 4 of histone H3 but was insensitive to ..
- Phosphorylation of histone H3 Thr-45 is linked to apoptosisPaul J Hurd
Wellcome Trust and Cancer Research UK, Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, United Kingdom
J Biol Chem 284:16575-83. 2009..Here, we identify threonine 45 of histone H3 (H3T45) as a site of phosphorylation in vivo...
- The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignmentJun Dai
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 19:472-88. 2005..Thr 3 of histone H3 is highly conserved, but the significance of its phosphorylation is unclear, and the identity of the corresponding ..
- Recognition of multivalent histone states associated with heterochromatin by UHRF1 proteinNataliya Nady
Ontario Cancer Institute, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada
J Biol Chem 286:24300-11. 2011..hemimethylated CpG sites, which are specifically recognized through its SRA domain and also interacts with histone H3 trimethylated on lysine 9 (H3K9me3) in an unspecified manner...
- Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cellsTae Hong Kang
Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang 790 784, Republic of Korea
Mol Cell Biol 27:8533-46. 2007..In mammals, aurora B is believed to be the mitotic histone H3 Ser10 kinase; however, it is not sufficient to phosphorylate H3 Ser10 with aurora B alone...
- Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensationH Goto
Laboratory of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Aichi 464 8681, Japan
J Biol Chem 274:25543-9. 1999Histone H3 (H3) phosphorylation at Ser(10) occurs during mitosis in eukaryotes and was recently shown to play an important role in chromosome condensation in Tetrahymena...
- Organismal differences in post-translational modifications in histones H3 and H4Benjamin A Garcia
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22901, USA
J Biol Chem 282:7641-55. 2007..Using a combination of mass spectrometric and immunobiochemical approaches, we show that the PTM profile of histone H3 differs significantly among the various model organisms examined...
- Methylation of histone H3 lysine 9 creates a binding site for HP1 proteinsM Lachner
Research Institute of Molecular Pathology, The Vienna Biocenter, Vienna, Austria
Nature 410:116-20. 2001..Here we show that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins--a family of heterochromatic adaptor molecules ..
- Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damageHengbin Wang
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Kaul Human Genetics Building Room 402A, 720 South 20th Street, 35294, USA
Mol Cell 22:383-94. 2006..Here, we report the purification and functional characterization of a histone H3 and H4 ubiquitin ligase complex, CUL4-DDB-ROC1...
- Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteinsYoung Hwa Goo
Department of Life Science, Pohang University of Science and Technology, Korea
Mol Cell Biol 23:140-9. 2003..a highly conserved 130- to 140-amino-acid motif termed the SET domain, which was recently implicated in histone H3 lysine-specific methylation activities...
- Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinaseUte Preuss
Institute of Genetics, University of Bonn, Roemerstrasse 164, D 53117 Bonn, Germany
Nucleic Acids Res 31:878-85. 2003..interacting protein (ZIP) kinase, is a nuclear serine/threonine-specific kinase that phosphorylates core histones H3 and H4, and myosine light chain in vitro...
- IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencingFeng Zhu
Science Park Research Division, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
Mol Cell 27:214-27. 2007..Trimethylated histone H3 lysine 9 (H3-K9) was found to associate with the histone trimethyltransferase Suv39h1 and DNA methyltransferase ..
- Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assemblyBin Kang
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Genes Dev 25:1359-64. 2011Histone H3 variant H3.3, while differing from canonical H3 (H3.1) by only five amino acids, is assembled into nucleosomes, along with histone H4, at genic regions by the histone chaperone HIRA, whereas H3...
- Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activationKwang Won Jeong
Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Nat Struct Mol Biol 18:1358-65. 2011..BRG1, leading to increased recruitment of histone methyltransferase MLL1 and increased monomethylation of histone H3 at Lys4...
- Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransportersAhmed S Khairalla
School of Life Sciences, University of Nottingham, Nottingham, UK
Cell Microbiol 17:1008-20. 2015..whereas in vitro clipping assays confirmed the ability of both proteins to proteolytically cleave the core histone H3. Finally, we show that App and MspA induce a dose-dependent increase in DC death via caspase-dependent apoptosis...
- Acetylation of HIV-1 integrase by p300 regulates viral integrationAnna Cereseto
Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology ICGEB, Trieste, Italy
EMBO J 24:3070-81. 2005..This is the first demonstration that HIV-1 IN activity is specifically regulated by post-translational modification...
- ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formationPanagiota Karagianni
Department of Medicine, Harvard Medical School and Massachusetts General Hospital Cancer Center, Building 149, Room 7 213, 13th Street, Charlestown, MA 02129, USA
Mol Cell Biol 28:705-17. 2008Methylation of histone H3 on lysine 9 is critical for diverse biological processes including transcriptional repression, heterochromatin formation, and X inactivation...
- Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatinSebastian Eustermann
Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
Nat Struct Mol Biol 18:777-82. 2011..wild-type ATRX protein targets pericentric and telomeric heterochromatin for deposition of the histone variant H3.3 by means of a largely unknown mechanism...
- Structures of human nucleosomes containing major histone H3 variantsHiroaki Tachiwana
Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162 8480, Japan
Acta Crystallogr D Biol Crystallogr 67:578-83. 2011..In the nucleosome, two copies of each core histone, H2A, H2B, H3 and H4, form a histone octamer which wraps 146 base pairs of DNA around itself...
- Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactionsAlexander J Ruthenburg
Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA
Cell 145:692-706. 2011..The second PHD finger of human BPTF is known to specifically recognize histone H3 when methylated on lysine 4 (H3K4me2/3)...
- Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenasesWei Xu
State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Medical School, Fudan University, Shanghai 20032, China
Cancer Cell 19:17-30. 2011..Hence, tumor-derived IDH1 and IDH2 mutations reduce α-KG and accumulate an α-KG antagonist, 2-HG, leading to genome-wide histone and DNA methylation alterations...
- Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerinFrancine Bruston
Unit of Functional and Adaptive Biology BFA affiliated with CNRS, Universite Paris Diderot Paris 7, Paris, France
FEBS Lett 584:2999-3004. 2010..We show that progerin tail has a reduced DNA/chromatin binding capacity and modified trimethylated H3K27 binding pattern, offering a molecular mechanism for heterochromatin alterations related to HGPS...
- Retroviral cyclin enhances cyclin-dependent kinase-8 activityJoel Rovnak
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA
J Virol 86:5742-51. 2012..activity of immune affinity-purified CDK8 in vitro for RNA polymerase II carboxy-terminal domain (CTD) and histone H3 substrates. PP2A also enhances CDK8 kinase activity in vitro for the CTD but not for histone H3...
- RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage responseLynda M Groocock
Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
EMBO Rep 15:601-8. 2014..Furthermore, RNF4 nucleosome-targeting is crucially required for the repair of TRF2-depleted dysfunctional telomeres by 53BP1-mediated non-homologous end joining. ..
- UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tailSi Xie
Department of Biochemistry, The University of Hong Kong, Hong Kong, China
J Mol Biol 415:318-28. 2012..Here, we report the high-resolution crystal structure of UHRF1 PHD finger in complex with N-terminal tail of histone H3. We found that the preceding zinc-Cys4 knuckle is indispensable for the PHD finger of UHRF1 to recognize the first ..
- Mitotic phosphorylation of histone H3 threonine 80Sharra L Hammond
Department of Biochemistry and Molecular Biology University of Texas MD Anderson Cancer Center Houston, TX USA Department of Molecular and Cellular Biology Baylor College of Medicine Houston, Texas USA
Cell Cycle 13:440-52. 2014..Among the proteins that are phosphorylated during mitosis is histone H3, which is heavily phosphorylated on its N-terminal tail...
- Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replicationAtsuya Nishiyama
Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467 8601, Japan
Nature 502:249-53. 2013..Here we show that Uhrf1-dependent histone H3 ubiquitylation has a prerequisite role in the maintenance DNA methylation...
- Expanding cofactor repertoire of protein lysine methyltransferase for substrate labelingKabirul Islam
Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States
ACS Chem Biol 6:679-84. 2011..This approach is thus suitable for substrate characterization of G9a and expected to further serve as a starting point to evolve other PKMTs to utilize a similar set of cofactors...
- A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosisFangwei Wang
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Curr Biol 21:1061-9. 2011Haspin phosphorylates histone H3 at Thr3 (H3T3ph) during mitosis [1, 2], providing a chromatin binding site for the chromosomal passenger complex (CPC) at centromeres to regulate chromosome segregation [3-5]...
- Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligaseLi Lan
Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 287:12036-49. 2012..The partial eviction of H3 from the nucleosomes is dependent on ubiquitinated H2A Lys-119/Lys-120...
- Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulationJing Li
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China
J Biol Chem 287:10089-98. 2012..Thus, our study has identified a novel H3K4me2-binding protein and revealed a role of NRDc in transcriptional regulation...
- ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndromeShigeki Iwase
Division of Newborn Medicine, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Nat Struct Mol Biol 18:769-76. 2011..Here we identify ADD(ATRX) as a previously unknown histone H3-binding module, whose binding is promoted by lysine 9 trimethylation (H3K9me3) but inhibited by lysine 4 ..
- CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcriptionHitomi Nishio
Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Proc Natl Acad Sci U S A 101:11257-62. 2004..with CDP/cut, and CDP/cut is directly associated with an increase in the methylation in vivo of Lys-9 in histone H3 within the CDP/cut-regulatory region of the p21(waf1/cdi1) promoter...
- The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferasesPamela Zhang
Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
Nucleic Acids Res 40:4237-46. 2012..KMTs), which includes MLL1-5, SET1A and SET1B, catalyzes the methylation of lysine-4 (Lys-4) on histone H3. Recent reports have demonstrated that a three-subunit complex composed of WD-repeat protein-5 (WDR5), ..
- Structural insight into recognition of methylated histone tails by retinoblastoma-binding protein 1Weibin Gong
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
J Biol Chem 287:8531-40. 2012....
- Controlling nuclear JAKs and STATs for specific gene activation by IFNγEzra N Noon-Song
Department of Microbiology and Cell Science, University of Florida, P O Box 110700, Gainesville, FL 32611 0700, USA
Biochem Biophys Res Commun 410:648-53. 2011..that activated Janus kinases pJAK2 and pJAK1 also played a role in gene activation by phosphorylation of histone H3 on tyrosine 41. This study addresses the question of the role of activated JAKs in specific gene activation by IFNγ...
- JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptorKenichi Yamane
Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Cell 125:483-95. 2006..Thus, our work identifies a histone demethylase and links its function to hormone-dependent transcriptional activation...
- The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylationLipeng Wu
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
Mol Cell 43:132-44. 2011..H2B K34ub by MSL1/2 directly regulates H3 K4 and K79 methylation through trans-tail crosstalk both in vitro and in cells...
- Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: towards understanding selectivity of inhibitors targeting oncogenic histone demethylasesJan B L Kristensen
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
FEBS Lett 585:1951-6. 2011..This demonstrates that despite very similar active site topologies, selectivity between Jumonji family histone demethylases can be obtained even with small molecule ligands...
- Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylationScott B Rothbart
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Nat Struct Mol Biol 19:1155-60. 2012..Here we show that UHRF1 association with methylated histone H3 Lys9 (H3K9) is required for DNA methylation maintenance...
- Histone demethylation mediated by the nuclear amine oxidase homolog LSD1Yujiang Shi
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Cell 119:941-53. 2004..LSD1 specifically demethylates histone H3 lysine 4, which is linked to active transcription...
- Nucleosomal H2B ubiquitylation with purified factorsJaehoon Kim
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Methods 54:331-8. 2011....
- Biophysical analysis and small-angle X-ray scattering-derived structures of MeCP2-nucleosome complexesChenghua Yang
Department of Biochemistry and Molecular Biology and Howard Hughes Medical Institute, Colorado State University, Fort Collins, CO 80523 1870, USA
Nucleic Acids Res 39:4122-35. 2011..We present ab initio envelope reconstructions of nucleosomes and their complexes with MeCP2 from SAXS data. SAXS studies also revealed unexpected sequence-dependent conformational variability in the nucleosomes themselves...
- Condensin association with histone H2A shapes mitotic chromosomesKenji Tada
Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113 0032, Japan
Nature 474:477-83. 2011..Our results elucidate the molecular basis for the spatiotemporal regulation of mitotic chromosome architecture, which is crucial for chromosome partitioning...
- Two histone marks establish the inner centromere and chromosome bi-orientationYuya Yamagishi
Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113 0032, Japan
Science 330:239-43. 2010..Here, we show that the phosphorylation of histone H3-threonine 3 (H3-pT3) mediated by Haspin cooperates with Bub1-mediated histone 2A-serine 121 (H2A-S121) ..
- Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1Kyohei Arita
Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
Proc Natl Acad Sci U S A 109:12950-5. 2012..crystal structure of the linked histone reader modules of UHRF1 in complex with the amino-terminal tail of histone H3. Our structural and biochemical data provide the basis for combinatorial readout of unmodified Arg-2 (H3-R2) and ..
- Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNAYongxin Yu
Molecular Biology Institute and Department of Biological Chemistry, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Mol Cell 46:7-17. 2012..Of the modified sites, histone H3 lysine 56 (H3K56) is unique in that it lies within the globular core domain near the entry-exit sites of the ..
- TdIF2 is a nucleolar protein that promotes rRNA gene promoter activityKotaro Koiwai
Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba, Japan
Genes Cells 16:748-64. 2011..In addition, TdIF2 promotes upstream binding factor (UBF) acetylation in vivo. Thus, TdIF2 might promote hrDNAP activity by suppressing Tip60's HAT activity and promoting UBF acetylation...
- Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tailsWeiqun Shen
School of Life Sciences, and Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui, 230026, People s Republic of China
Biochemistry 46:2100-10. 2007..0 and 3.6 mM, respectively. In this study the dominant substrate was H3-AcK14 (KD approximately 1.2 mM). Mutagenesis analysis reveals several residues important for the binding specificity...
- Biochemical characterization of human SET and MYND domain-containing protein 2 methyltransferaseJiaquan Wu
Oncology Innovative Medicines Unit, AstraZeneca Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, USA
Biochemistry 50:6488-97. 2011..Taken together, these results demonstrated the functional importance of distinct domains in the SMYD family of proteins and further advanced our understanding of the catalytic mechanism of this family...
- Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicityEirene Kontopoulos
Department of Pathology, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Hum Mol Genet 15:3012-23. 2006..Alpha-synuclein binds directly to histones, reduces the level of acetylated histone H3 in cultured cells and inhibits acetylation in histone acetyltransferase assays...
- A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chainAdam J L Cook
Institut Curie, Centre de Recherche, Paris F 75248, France
Mol Cell 44:918-27. 2011..that the histone chaperone nuclear autoantigenic sperm protein (NASP) protects a reservoir of soluble histones H3-H4...
- Nuclear epidermal growth factor receptor modulates cellular radio-sensitivity by regulation of chromatin accessKlaus Dittmann
Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tubingen, Germany
Radiother Oncol 99:317-22. 2011..Nuclear EGFR is involved in cellular stress management and regulation of cellular radio-sensitivity. The aim of this study was to elucidate the molecular mode of nuclear EGFR action...
- Structural and histone binding ability characterizations of human PWWP domainsHong Wu
Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 6:e18919. 2011..While Tudor, chromodomain and MBT domains have long been known to bind methylated histones, PWWP was shown to exhibit histone binding ability only until recently...
- And-1 is required for the stability of histone acetyltransferase Gcn5Y Li
Department of Biochemistry and Molecular Biology, The George Washington University Medical School, Washington, DC 20037, USA
Oncogene 31:643-52. 2012..domain-containing protein) has remarkable capability to regulate the stability of Gcn5 proteins and thereby histone H3 acetylation. We find that And-1 forms a complex with both histone H3 and Gcn5...
- 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding siteMassimo Ghizzoni
Department of Pharmaceutical Gene Modulation, Groningen Research Institute of Pharmacy, University of Groningen A Deusinglaan 1, 9713 AV, Groningen, The Netherlands
Eur J Med Chem 47:337-44. 2012..In addition, these HAT inhibitors effectively inhibited acetyltransferase activity of nuclear extracts on the histone H3 and H4 at micromolar concentrations.
- Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cellsJ Paggetti
Inserm UMR 866, Faculty of Medicine, University of Burgundy, Dijon, France
Oncogene 29:5019-31. 2010..We also found that WDR5, an adaptor protein essential for lysine 4 trimethylation of histone H3 (H3K4me3) by MLL, colocalizes and interacts with MOZ...
- The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5Matthieu Lacroix
Institut de Genetique Moleculaire de Montpellier, Universite de Montpellier, Montpellier 34293, France
EMBO Rep 9:452-8. 2008..PRMT5 bound to COPR5 methylates histone H4 (R3) preferentially when compared with histone H3 (R8), suggesting that COPR5 modulates the substrate specificity of nuclear PRMT5-containing complexes, at least ..
- Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1Ho Geun Yoon
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
EMBO J 22:1336-46. 2003..Together, our data reveal the roles of HDAC3 and TBL/TBLR1 and provide evidence for the functional importance of histone interaction in repression mediated by SMRT-N-CoR complexes...
- Histone demethylation by a family of JmjC domain-containing proteinsYu Ichi Tsukada
Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
Nature 439:811-6. 2006..protein, JHDM1 (JmjC domain-containing histone demethylase 1), that specifically demethylates histone H3 at lysine 36 (H3-K36)...
- Expression patterns and post-translational modifications associated with mammalian histone H3 variantsSandra B Hake
Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
J Biol Chem 281:559-68. 2006..Interest in non-allelic histone variants has been renewed, in part because of recent work on H3 (and other) histone variants. However, only in mammals do three non-centromeric H3 variants (H3.1, H3.2, and H3...
- Modifications of human histone H3 variants during mitosisBenjamin A Garcia
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA
Biochemistry 44:13202-13. 2005Phosphorylation of histone H3 is a hallmark event in mitosis and is associated with chromosome condensation...
- Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alphaHong Seok Choi
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
J Biol Chem 280:13545-53. 2005The mitogen-activated protein kinase cascades elicit modification of chromatin proteins such as histone H3 by phosphorylation concomitant with gene activation...
- Functional characterization of a human histone gene cluster duplicationCorey D Braastad
Department of Cell Biology and Cancer Center, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655 0002, USA
Gene 342:35-40. 2004..Levels of messenger RNAs for duplicated histone H4 genes are high relative to those for non-duplicated H4 genes. Our data suggest that transcriptionally robust histone H4 genes may have been preferentially duplicated during evolution...
- Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaksYentram Huyen
Wistar Institute, Philadelphia, Pennsylvania 19104 4268, USA
Nature 432:406-11. 2004..In vitro, the 53BP1 tandem tudor domain bound histone H3 methylated on Lys 79 using residues that form the walls of the pocket; these residues were also required for ..
- Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1Meenakshisundaram Ananthanarayanan
Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 279:54348-57. 2004..This methyltransferase activity is directed specifically to arginine 17 of histone H3. We demonstrate that FXR is directly associated with co-activator-associated arginine methyltransferase 1 (CARM1) ..
- Human PAD4 regulates histone arginine methylation levels via demethyliminationYanming Wang
Department of Genetic Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Science 306:279-83. 2004..PAD4 targets multiple sites in histones H3 and H4, including those sites methylated by coactivators CARM1 (H3 Arg17) and PRMT1 (H4 Arg3)...
- Phosphorylation of histone H2A inhibits transcription on chromatin templatesYe Zhang
Department of Pathology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 279:21866-72. 2004..Furthermore, we found that acetylation of histone H3 by the p300 and CREB-binding protein associated factor, PCAF, suppressed the kinase-dependent inhibition of ..
- Structural basis for the methylation site specificity of SET7/9Jean Francois Couture
Department of Biological Chemistry, University of Michigan, 1301 Catherine Road, Ann Arbor, Michigan 48109 0606, USA
Nat Struct Mol Biol 13:140-6. 2006Human SET7/9 is a protein lysine methyltransferase (PKMT) that methylates histone H3, the tumor suppressor p53 and the TBP-associated factor TAF10...
- BRCA1 supports XIST RNA concentration on the inactive X chromosomeShridar Ganesan
The Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cell 111:393-405. 2002..These observations suggest that loss of BRCA1 in female cells may lead to Xi perturbation and destabilization of its silenced state...
- Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensationHidemasa Goto
Division of Biochemistry, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Aichi464 8681, Japan
Genes Cells 7:11-7. 2002Histone H3 (H3) phosphorylation plays important roles in mitotic chromosome condensation. We reported that H3 phosphorylation occurs at Ser28, as well as at Ser10 during mitosis, at least in mammals...
- Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivatorsN Shikama
Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, United Kingdom
Mol Cell Biol 20:8933-43. 2000..These results argue that NAP is a functionally important component of the p300 coactivator complex and suggest that NAP may serve as a point of integration between transcriptional coactivators and chromatin...
- The genomic organization of the histone clusters on human 6p21.3J Ahn
Yale Child Health Research Center, Department of Pediatrics, Yale University School of Medicine, 464 Congress Avenue, New Haven, Connecticut 06520 8081, USA
Mamm Genome 10:768-70. 1999
- Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assayC Díaz-Jullien
Departamento de Bioquimica y Biologia Molecular, Facultad de Biologia, Universidad de Santiago, Spain
Biochim Biophys Acta 1296:219-27. 1996..Pro T alpha and histones in solution) indicated that Pro T alpha has higher affinity for core histones (particularly H3 and H4) than for H1...
- Fine mapping of the human pentraxin gene region on chromosome 1q23M T Walsh
Department of Genetics and Biotechnology Institute, University of Dublin, Trinity College, Dublin, Ireland
Immunogenetics 44:62-9. 1996..In addition, it contains the histone H3F2 and H4F2 genes and the gene for erythroid alpha-spectrin (SPTA1). The gene order is cen...
- Human spleen histone H3. Isolation and amino acid sequenceY Ohe
J Biochem 90:1205-11. 1981The amino acid sequence of human spleen histone H3 was investigated as a study in histone evolution, following previous investigations of human spleen histone H2B [Ohe, Y., Hayashi, H., & Iwai, K. (1979) J. Biochem...
- A major human histone gene cluster on the long arm of chromosome 1L Green
Science 226:838-40. 1984..blot analysis of DNA's from a series of mouse-human somatic cell hybrids with 32P-labeled cloned human H4 and H3 histone DNA as probes...
- Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expressionKhairul I Ansari
Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, USA
Biochim Biophys Acta 1779:66-73. 2008Human encodes several histone H3-Lysine 4 (H3K4) specific methyl-transferases (HMTs) such as MLL1 (mixed lineage leukemia 1), MLL2, MLL3, hSet1 etc, that play critical roles in gene expression...
- Histone H3-K56 acetylation is important for genomic stability in mammalsJian Yuan
Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 555902, USA
Cell Cycle 8:1747-53. 2009Histone H3 lysine 56 acetylation (H3K56Ac) has recently been identified and shown to be important for genomic stability in yeast. However, whether or not H3K56 acetylation occurs in mammals is not clear...
- HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tailNehme Saksouk
Laval University Cancer Research Center, Hôtel Dieu de Québec CHUQ, Quebec City, QC, Canada
Mol Cell 33:257-65. 2009..Biochemical and functional analyses indicate that these domains interact with histone H3 N-terminal tail region, but with a different specificity toward its methylation status...
- Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancerQingshan Chang
Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
J Hepatol 50:323-33. 2009..It remains unclear whether JNK activation plays an important role in human HCC and, if so, how JNK signaling contributes to the initiation or progression of HCC...
- Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressorP V Peña
Department of Pharmacology, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045 0511, USA
J Mol Biol 380:303-12. 2008..apoptotic activities of ING1 require the interaction of the C-terminal plant homeodomain (PHD) finger with histone H3 trimethylated at Lys4 (H3K4me3)...
- Structural basis and binding properties of the second bromodomain of Brd4 with acetylated histone tailsYing Liu
Biochemistry 47:6403-17. 2008..With its tandem bromodomains, Brd4 avidly binds to diacetylated H4-AcK5/K12 and H3-AcK9/K14 peptides. Solution structure of the second bromodomain (BD) is reported in this research...
- Prokaryotic BirA ligase biotinylates K4, K9, K18 and K23 in histone H3Keyna Kobza
Departments of Nutrition and Health Sciences, University of Nebraska at Lincoln, Lincoln, NE, USA
BMB Rep 41:310-5. 2008..Incubation of recombinant BirA ligase with H3-based synthetic peptides showed that lysines 4, 9, 18, and 23 in histone H3 are the targets for the biotinylation by ..
- Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fatesLei Wang
Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
EMBO Rep 9:555-62. 2008..and that both the ELM2 and SANT domains orchestrate molecular events that lead to a stable methylation of histone H3-lysine 9...
- Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequencesF Marashi
Biochem Cell Biol 64:277-89. 1986We examined the structural and functional properties of a human H3 histone gene promoter. The complete nucleotide sequence of an H3 structural gene and 515 nucleotides of 5' and 100 nucleotides of 3' flanking sequences were determined...
- Molecular basis of histone H3K4me3 recognition by ING4Alicia Palacios
Structural Biology Unit, CIC bioGUNE, Parque Tecnologico de Bizkaia, Edificio 800, 48160 Derio, Spain
J Biol Chem 283:15956-64. 2008..Our results illustrate the versatility of PHD fingers as readers of the histone code...
- A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylationHeinz Neumann
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, England, UK
Mol Cell 36:153-63. 2009..With these designer nucleosomes, we demonstrate that, in contrast to the prevailing dogma, acetylation of H3 K56 does not directly affect the compaction of chromatin and has modest effects on remodeling by SWI/SNF and RSC...
- PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylationDawin Hyllus
Institute of Molecular Biology and Tumor Research IMT, Philipps University of Marburg, 35032 Marburg, Germany
Genes Dev 21:3369-80. 2007..We show here that PRMT6 methylates histone H3 at R2 and histones H4/H2A at R3 in vitro...
- Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulationEric Metzger
Universitäts Frauenklinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany
Nat Cell Biol 10:53-60. 2008..Here we show that protein-kinase-C-related kinase 1 (PRK1) phosphorylates histone H3 at threonine 11 (H3T11) upon ligand-dependent recruitment to androgen receptor target genes...
- Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repressionFei Lan
Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 448:718-22. 2007..LSD1 is a lysine-specific histone demethylase that represses transcription by demethylating histone H3 on lysine 4 (ref. 1)...
- PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformationAlessio Zippo
Dipartimento di Biologia Molecolare Università di Siena, Via Fiorentina 1, 53100 Siena, Italy
Nat Cell Biol 9:932-44. 2007..PIM1 to the E boxes of the MYC-target genes FOSL1 (FRA-1) and ID2, and PIM1 phosphorylates serine 10 of histone H3 (H3S10) on the nucleosome at the MYC-binding sites, contributing to their transcriptional activation...
- Identification of histone H3 lysine 36 acetylation as a highly conserved histone modificationStephanie A Morris
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
J Biol Chem 282:7632-40. 2007..Here we identify and characterize histone H3K36 acetylation (H3K36ac). By mass spectrometric analyses of H3 purified from Tetrahymena thermophila and Saccharomyces cerevisiae (yeast), we find that H3K36 can be acetylated or ..
- Histone acetylation-independent transcription stimulation by a histone chaperoneKohsuke Kato
Department of Infection Biology, Graduate School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
Nucleic Acids Res 35:705-15. 2007..These results suggest that TAF-I remodel the chromatin structure through its interaction with the core domain of the histones, including the histone fold, and this mechanism is independent of the histone acetylation status...
- Quantitative proteomic analysis of post-translational modifications of human histonesHans Christian Beck
Danish Technological Institute, Holbergsvej 10, DK 6000 Kolding, Denmark
Mol Cell Proteomics 5:1314-25. 2006..A total of 32 acetylations, methylations, and ubiquitinations were located in the human histones H2A, H2B, H3, and H4, including seven novel modifications...
- Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17Feng Miao
Gonda Diabetes Center, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
Mol Endocrinol 20:1562-73. 2006..the coactivators p160 and cAMP response element binding protein-binding protein (CBP) and methylation of histone H3 at arginine 17 (H3-R17)...


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The after-disaster of all the cooking, baking, and eating in life stinks. There's food to put away, spills to wipe up, dishes to wash, and for some strange reason everyone else in the house mysteriously disappears post-meal. Hmmmmmm.
Plus, there's always that one pan which needs a little extra tough scrubbin'.
Like this one.
I have to admit that I didn't know there was that much of a difference between dish washing liquids. I only figured it out this month when I set aside my "Liquid Cheap" in order to try out Dawn Ultra.
Here's the thing: they both clean the dishes, but Dawn Ultra does it quicker, easier and with less product.
And omg, the suds lasted forever! I filled that pan and forgot about it for two hours. When I came back, it looked exactly like it did when I left, and even then the bubbles didn't disappear when I started washing. Impressive, I gotta say.
Dawn Ultra contains double the everyday grease cleaning ingredients in every drop versus the leading non-concentrated dish soap. Dawn cleans 2X more greasy dishes while suds last making clean-up quick and easy.
Now moving beyond the sink over to the dishwasher…
As much as I love having a dishwasher do the washing for me, it's only as good as the detergent inside it, right? And believe me, I've learned my lesson with that.
There's a huge difference between brands and formulas, and Cascade Complete Pacs are one of the few kinds I like.
They pop neatly into my detergent compartment and they eliminate the need for pre-rinsing (but I still kinda like to do that). Best of all, the dishes come out sparkling clean and free of food residue.
Cascade Complete Pacs combine the best of powder and gel in one pac to power away 24-hour, stuck-on food. Eliminates the needs to pre-wash since each formula can dissolve tough food particles.
One lucky reader will win a Dawn prize pack including: Dawn Ultra, Dawn Hand Renewal, 2 Dawn Power Clean, and Dawn Bleach Alternative.
Products were provided. All opinions are my own.
RULES: Giveaway ends 11:59 pm ET, March 16, 2013. No purchase necessary. Open to legal residents of the fifty (50) United States and District of Columbia, Eighteen (18) years of age or older. Void where prohibited by law. One lucky winner will be chosen using random.org. One entry per household and IP address. The number of eligible entries received determines the odds of winning. Cheating will not be tolerated, and entries will be verified for accuracy. I will email the winner and they will have 48 hours to respond to the notification email, or a new winner will be chosen. Entering this giveaway means you are in agreement with this blog's Terms of Use policy.


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With immigration reform in the national spotlight, Equal Voice News wants to hear feedback from readers about ideas that might work, what needs more thinking – and what is missing from the public discussion.
Why? Personal experiences matter – and they can make better policy.
There is much to consider: President Barack Obama on Tuesday presented his immigration ideas, a day after a group of bipartisan senators issued their thoughts. On Sunday, the Illinois governor signed a bill into law, which gives undocumented immigrants permission to receive driver's licenses.
Last week, a new poll showed that a majority of Americans support citizenship for undocumented immigrants, the Associated Press reported.
For years, grass-roots immigration groups from throughout the United States have been working on the issue so families are not torn apart and that people can have safe, stable lives.
On the Equal Voice News media platforms – which include Facebook and Twittter – let us know what you think about the national proposals and ideas being discussed in your family or community. On Twitter, use the hashtag #MyVoice.
At the bottom of each Equal Voice News story, there's also a comment area. Equal Voice News also will be keeping an eye out for reaction from community groups in the country.
Also, visit Equal Voice News later to read reporter Kathy Mulady's moving story about immigration, what happened to one family in Arizona and how community advocates are working throughout the country on a topic that is now on the president's mind.
Equal Voice also has archived stories about immigration.


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Kirkus Reviews Best Children's Book
IndieBound Indie Next List
About the Book
Fox Street was a dead end. In Mo Wren's opinion, this was only one of many wonderful, distinguishing things about it.
Mo lives on Fox Street with her dad and little sister, the Wild Child. Their house is in the middle of the block—right where a heart would be, if the street were a person. Fox Street has everything: a piano player, a fix-it man, the city's best burrito makers, a woman who cuts Mo's hair just right, not to mention a certain boy who wants to teach her how to skateboard. There's even a mean, spooky old lady, if ringing doorbells and running away, or leaving dead mice in mailboxes, is your idea of fun. Summers are Mo's favorite time, because her best friend, Mercedes, comes to stay.
Most important, though, Fox Street is where all Mo's memories of her mother live. The idea of anything changing on Fox Street is unimaginable—until it isn't.
This is the story of one unforgettable summer—a summer of alarming letters, mysterious errands, and surprising revelations—and how a tuft of bright red fur gives Mo the courage she needs.
Educator and Librarian Resources
Critical Praise
Springstubb effectively turns the neighborhood into a character in its own right, one that's loving and protective. Mo's voice is original, though it has tinctures of Scout and Harriet. What happened on Fox Street? Love, belief and caring. — Kirkus Reviews (starred review)
Springstubb creates a richly human and believable story of the conflicts of growing up and a well-paced, interesting plot with plenty of surprises that readers should find pleasurable and satisfying — School Library Journal
Product Details
- Imprint: Balzer + Bray
- On Sale: 08/24/2010
- Pages: 240
- List Price: 4.99 USD
- Ages: 8 to 12
- BISAC1: JUVENILE FICTION / Girls & Women
- BISAC2: JUVENILE FICTION / Family / General (see also headings under Social Themes)
- BISAC3: JUVENILE FICTION / Social Themes / Friendship


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ABC News' Karen Travers reports:
Vice President Joe Biden announced today that just a week after President Obama signed the $787 billion economic stimulus bill, $15 billion in Medicaid funds are on their way to state governments and more announcements will come over the next week as the money starts flowing.
Biden said the Department of Housing and Urban Development today will give $10 billion to state and local governments to create and fund jobs through public housing projects.
Biden chaired the first meeting focused on oversight and implementation of the stimulus funds, a job he was given because " nobody messes with Joe ," President Obama said last night.
Biden said several times that this level and type of oversight is unprecedented and warned that he was going to be tough.
"I'm going to be a bit of a pain in the neck," Biden said, telling Cabinet members that they will be having weekly meetings on this issue.
OMB Director Peter Orszag said that the web site the White House set up --- www.recovery.gov -- is getting 3,000 hits per second, which the Obama Administration believes is a sign of the strong interest in accountability and transparency for this massive amount of federal dollars.
Biden: We Will Publicly Embarrass Those Who Misuse Funds
This morning Biden put states on notice and made it clear that the White House is not going to sit back and do nothing if stimulus funds are misused.
"In some cases, we can withdraw the money, we can hold them accountable. And in other places we'll just use the television, the radio and the media to embarrass them for not doing what they're supposed to do," Biden said to Good Morning America's Robin Roberts.
At the White House, Biden repeated his pledge to take to the airwaves to shame those who misuse the funds. "If the money's not being out there spent, I'm going to go on television and say, 'You know, we gave so and so X amount of dollars and nothing's happened. Why hasn't it happened?'"
Biden was joined in the meeting by Treasury Secretary Geithner; HUD Secretary Shaun Donovan; EPA Administrator Lisa Jackson; Agriculture Secretary Tom Vilsack; Interior Secretary Ken Salazar; Transportation Secretary Ray LaHood; Education Secretary Arne Duncan and Energy Secretary Steven Chu.
-- Karen Travers


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List Entry Summary
This building is listed under the Planning (Listed Buildings and Conservation Areas) Act 1990 as amended for its special architectural or historic interest.
Name: ANGLESEY ABBEY
List entry Number: 1331433
The building may lie within the boundary of more than one authority.
County: Cambridgeshire
District: East Cambridgeshire
District Type: District Authority
Parish: Lode
National Park: Not applicable to this List entry.
Grade: I
Date first listed: 01-Dec-1951
Date of most recent amendment: Not applicable to this List entry.
Legacy System Information
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(North Side)
9/53; 10/53 Anglesey Abbey
Country house incorporating part of a priory of Augustinian Canons. C13 origin, converted to a house C17, enlarged C19 and C20 (part by Sir A Richardson). Limestone and clunch with steeply pitched, tiled roof. Two main ranges forming a T-plan. The range to the North was originally a first floor hall with an undercroft, and detached from the South range. It was probably the Abbots Lodging. The original building has been added to on the North and South. The gable end walls are visible internally. At the left hand of the East wall the surface has been cut back indicating an extension or range on the East side. The walls are of coursed clunch with some Barnack limestone particularly in the lower courses. On the East wall there are two, two-stage buttresses. The upper stage has been rebuilt but the lower stage of clunch and Barnack on a splayed sill is C13. The upper part of the walls has been rebuilt and the steeply pitched, tiled roof is C19 or C20. The West wall is obscured by later building. The lodgings were of three bay plan, and of two storeys and an undercroft. The original entry was on the West side at the North end. The present fenestration is C17 or dates from the restoration in C19 or C20 but there is a two centred arch and the springing for a second arch at ground floor which are C13. The South range is also C13 in origin and of clunch with some Barnack but its original use is uncertain. In the early C17 it was converted to domestic use probably by the Fowkes family, and the present external appearance is generally of a house of that period. The roof is steeply pitched with later end parapets, but early C17 end stacks of clunch and reused Barnack limestone. The shafts set diagonally on the base are all later. Two storeys and attics. Five C20 gabled eaves dormers in style of and replacing five similar dormers. The main elevation is in five bays, each with a five light cross frame casement of clunch or restored in limestone, except for the centre bay which has an early C17 two storey porch. The doorway is in a round headed and double wave moulded arch on a high sill with a renewed, jewelled keyblock at the centre. Above is a reset medieval carving of stone and a similar casement window. Surmounting the porch is a pediment of "C" and "S" scrolls on either side of a late C18 Coadestone sculpture of St George and the Dragon. To the right hand is a two storey canted oriel window with cross-frame casements of clunch. In 1955, a gallery was added to the end of the Abbots lodging or North range. This was designed by Sir Albert Richardson. The interior of the North range or former Abbots lodging contains two features of importance. The first is the undercroft which is in three bays and two aisles with quadripartite rib vaulting with chamfered arches springing from octagonal columns with moulded capitals and hold water bases. At the walls the arches spring from triple lobed corbels. Much of the stonework, including the marble columns, has been renewed. The second feature is on what was formerly the South West external wall. It is part of the raking wall arches to what was the staircase entry to the first floor hall. Only four and a half two centred arches of triple hollow and roll moulding with a continuous roll moulded label survive. The arches spring from corbels which have been badly mutilated. The South range contains little internally even from the 1600 alterations. A doorway to the South porch has a reversed arch with spandrels carved with "PW" and "R" for William Reche, prior from 1515 and probably reset. The fireplaces and surrounds are mostly early C17 and inserted during Lord Fairhaven's ownership. The roof is of c1600 and of staggered, butt purlin construction. The priory was founded in early C13 on the site of a c12 hospital of St Mary. Much of the priory was dismantled after the dissolution but one range was converted to a house in early C17. The house was acquired by Lord Fairhaven in 1926 who added some of the buildings on the West and the Gallery on the North.
R.C.H.M. (North East Cambs.), p74, mon (3) Pevsner: Buildings of England, p291
Listing NGR: TL5302162256
Selected Sources
Books and journals
Pevsner, N, The Buildings of England: Cambridgeshire, (1954), 291
An Inventory of the Historical Monuments in Cambridgeshire North East, (1972)
Register of Parks and Gardens of Special Historic Interest in England, Part 5 Cambridgeshire,
National Grid Reference: TL 53021 62256
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Tuesday, June 30, 2009
No. Nope. Not even a little.
Quite frankly, I'm rather calm about this. She's not going to stay in forever. She'll come when she wants to, and who am I to tell her different? So far I feel fine, IF A BIT ANXIOUS, YOU KNOW, and so whatever, I wait and make jokes at the doctor's office.
So today -- perhaps out of hope, perhaps out of disbelief that a woman 5 days overdue could have a sense of humor about it -- my nurse took a long time to find the heartbeat with her baby stethoscope thing while I tried not to panic.
(I don't care who you are or how many times you've done this, I think every time you don't hear your baby's heartbeat, your own heart stops.)
"I think she's riding high," I offered, because that was the case last week.
But even still, even after checking and seeing the image on the screen, the nurse seemed determined not to place the stethoscope above my belly button until she got desperate. Because that's not where a baby who is getting ready to be born should be.
But that's where she was.
After our check-up, the nurse said we should head to the hospital for another round of non-stress tests (NSTs) like we did last week. Guess it's SOP for when you're overdue. So we scheduled another appointment with a delivery doctor for Monday -- if we haven't had the baby by then, we should be prepared to make "a plan" then.
We then went to the hospital and listened to the baby for a half-hour. Everything looks perfect, and my blood pressure is back to normal. We scheduled our next NST for Friday. But the nurse at the hospital said we should pack our stuff for Friday's appointment "just in case."
So hmmmm.
At this point, I'd be shocked if she arrived before Friday. I'd also be surprised if they felt the need to induce me Friday if I haven't made any progress. Which is all to say that if she doesn't come in the next 24-48 hours, they might induce on Friday. Unless they don't. And then if she doesn't come after that, they'll check me again on Monday and induce me then. Unless they don't.
It's quite scientific, you see.
* * * * *
As I was walking down the hospital corridor on my way to the maternity ward for the third time in a week despite non-imminent labor, I honestly wanted to throw open the door and yell, WHAT IS UP, MA BITCHES!?!?! But I'm not totally insane and didn't. Instead, I Tweeted as much. No one seemed to think it was funny, but I think it's hilarious.
29 comments:
Your tweet totally made me LOL :P And I hoped you had actually done it. Alas. ;)ReplyDelete
my "word verification" thingie is "weening" LOL
The title of this post made me laugh out loud tooo! So that totally counts.ReplyDelete
I'm guessing you're in no hurry, but if you get to that point (by no means do I want to pry into private matters but..) try having a lot of sex. It's an old wives tale that it can speed things along. And a whole lot more enjoyable than being induced. :-)ReplyDelete
your title just made me snort!ReplyDelete
You are a pregnant woman. You are allowed to scream insane things.ReplyDelete
I think you are funny, even if the people of twitter didn't.ReplyDelete
Hang in there. You are so much more patient than I was as a pregnant woman. My son was born at 41weeks 6 days, and only after an induction, so I think I kinda know what you are going through...
It does not sound like you are tempted, but I will remind you this: DON'T DRINK THE CASTOR OIL. It won't make the baby come out. I promise you this.
Sounds damned funny to me and if I were on Twitter, I'd definitely had laughed.ReplyDelete
I hear you on the waiting thing - it's tough when you're just damned ready and the baby isn't. I about strangled my father when he called and said, 'you know Rach, just because you have a due date, it doesn't mean the baby will be born that exact day'. Ya think?
Mine was 9 days late - and was absolutely fine and healthy. Sending you wishes for the same (not the 9 days part - the fine/healthy part).
I don't twitter and your title got attention finally and I was so excited. I thought maybe...well, just maybe. It will be soon. I'm telling you she has headed for higher ground and isn't so hip on coming out. She is thinking "You want me to go through WHAT? No way in hell am I going to fit through that little exit!"ReplyDelete
Hang in there, kiddo. It has to happen sometime. With my first they induced me....it was not what I'd expected for sure.
My first was 7 days overdue and finally came on his own (even though I was begging for them to take him out, but I was in Davis, CA, where there was no way they were going to intervene). My second was induced a week early. Not really sure why. DON'T LET THEM INDUCE YOU!!! It makes labor so much worse, and if there's no medical reason to do it, I'd advise let your baby wait until she's ready. I'm pregnant now and will NOT let them induce me this time. Babies will come out when they're ready. You've never read of babies being born after 12 months gestation, have you??ReplyDelete
dude, i thought your tweet was very funny! totally made me laugh out loud alone in my living room. :-)ReplyDelete
- Anonymous9:32 PM, June 30, 2009
Kristy, I just had a baby in May and my story (and my body type!) sound similar to yours. My baby was NOT READY to come out and they made me schedule an induction because of a GD diagnosis. Not because she was showing ANY signs of distress or any other reason to induce. At my appt before the induction I was still "high and tight" and I begged my doc to postpone. She agreed to wait six days. Water broke on day three, baby born after a 36 hour labor.ReplyDelete
Long story short, don't let them freak you out and listen to your body :) Baby will come when ready.
5 days! HAH. My first child was born three weeks after his due date. It was 1963, and they didn't do inductions then, so other than drinking castor oil (old wive's rememdy and they were WRONG), we just waited. He was fine, I was fine, but I felt like I'd been pregnant for 300 years.ReplyDelete
- Rebecca6:25 AM, July 01, 2009
Oh crap, somehow I lost my comment half way through.ReplyDelete
Here (again) is some unsoliscited advice. Go to a health food store (do they have those in CA? hahaha) and buy Raspberry Leaf Tea (must be 'leaf') and Stinging Nettle Tea. Steep the two together for 10 minutes. You and Ish enjoy a mug tonight. Wait for the magic. (worked for me)
I was induced 2 weeks early with my daughter because she was showing no signs of coming anytime soon. Dr said that if they didn't induce rightthisverysecond, she was going to be too big for me to deliver without an emergency c-section. Long story short, they induced, 36 hours of labor later-she got here... at 6 lb, 10 oz. If I could have moved my legs at that point, I would have kicked that Dr. in the head for putting me through an induction for a baby not even 7 pounds! Dr's are stupid. And they can't make you have your baby any sooner than you're ready too. It sucks, but I'd say wait it out. Oh, and the sex thing is an old wives tale. Trust me on this.ReplyDelete
Can't you do jumping jacks or something? Beats me, I've never had a baby.ReplyDelete
I totally think you should have yelled that.
I'm new to your postings (this week) but can sympathize with being overdue. I won't bore you with the details (two pregnancies, two inductions, two (BIG) healthy, beautiful baby boys!).ReplyDelete
Anyway, like an expectant new auntie, I'm waiting patiently for news at my computer. Take this time to enjoy the peaceful quietness between you and Ish. "Peaceful quietness" will take on a different meaning when you become parents.
Wishing you luck with your new little "firecracker" over the holiday weekend. Just think - she began approximately nine months ago as fireworks, she just may choose to make her appearance over the holiday as an unforgettable firecracker, just like her Mommy!
I wish you the best, Kristy!ReplyDelete
Just to offer a different data point, I was induced (broke my water) at a week early (medical reasons) and my labor was 2 hours and 40 minutes. Zippy! But my son was dropped so low he was riding between my knees (seriously, the doctor expressed surprise I could walk) and I was dilated to SIX with no contractions. So obviously I was ready. Every person, every baby, every body is different. And as you say, she won't stay in forever, labor won't last forever, this will all be over.ReplyDelete
I think it would have hilarious to yell, "What's up, Ma Bitches?"ReplyDelete
Next time your at the hospital...do it!
- Anonymous9:43 AM, July 01, 2009
Every morning at work I log in to see if you've had the baby yet!! She will come when she's ready - maybe she just wants to hang out w/ mommy for a little while longer! :)ReplyDelete
DUDE! I just snorted tea, which isn't as painful as you might think. Interesting.ReplyDelete
Stay strong, Mamacita. I'm thinking good thoughts for you.
that's why they call it a medical "practice", right? My own kid arrived almost a MONTH to the day from my predicted "due date" so what the hell do they know?ReplyDelete
I will start saying "WUT UP, MA BITCHES?" and thinking labor inducing thoughts for you, because that is a wicked Klassy phrase right there! LOVES IT!
She's probably waiting to be a Yankee Doodle Dandy Baby like her mama! Hang in there!ReplyDelete
- kissashark3:56 PM, July 01, 2009
I'm not a mother, but I was born to one, I'd like to echo some of the statements here, she will come when she is ready. I was born 9 weeks past my due date(in 1976) and my mom's ob/gyn refused to induce because we were both fine, and because my brother had died the year before of SIDS. I was just over 10lbs at birth and it was au natural.ReplyDelete
I think Dr's are always in a big hurry to push that induction nonsense when our own bodies know when we are ready. I know you'll both be fine! :) Can't wait to see the little peanut!
my bundle of joy was 12 days overdue and then surprised me with rapid labor. It was the ONE chapter of any prego books I had not read (didn't think it could possibly apply). Apparently the rapid labor bit surprised the docs too because an hour before she was born they were telling me it would be at least TWELVE MORE HOURS, if I was LUCKY. She was a fabulous baby, an amazing kid, and now a pretty awesome 19 y-o, so she was more than worth the drama! (Although she is still QUITE the Drama Queen)ReplyDelete
Thinking happy thoughts for you!
- Anonymous5:20 PM, July 01, 2009
Philips Phile Surefire Birth RecipeReplyDelete
(Directions must be followed exactly)
The pregnant mother MUST be past her due date.
The father* of the unborn child MUST purchase a newbox of Kraft Macaroni & Cheese (the original elbows with the powdered cheese in the blue box), and a bottle of A-1 Steak Sauce.
The father* MUST make the entire box of Mac. & Cheese while the mom-to-be sits on her fat ass.
The mother can add as much or as little (the more, the better) A1 Steak Sauce to the Mac. & Cheese.
The mother MUST eat as much of the Mac. & Cheese as she can, preferably the entire box.
The proud father* should start packing the bags and warming up the car because mom will be in labor within 24 hours.
Send us a picture of the rug-rat.
* Note: Any male figure will do if the father is in prison or in the witness protection program.
The surefire recipe is guaranteed to work, (at least 9 out of 10 times) And if it doesn't, it means YOU screwed it up!
I'd eat that.ReplyDelete
But wait. I'm not sprogged up. What will the A1,Mac and Cheese combo do to a nonpregnant, not wanting to be, chica?
comming from a mother of 3, she will definitely come out when she is ready. I have no idea exactly how late my daughter was because I was actually on birth control when I conceived so kind of hard to get an exact date of conception. She is here now and has been for almost 8 years and believe me we all know she is here. Good luck with your baby girl. I really enjoy reading your blog.ReplyDelete
i thought it was funny :)ReplyDelete
you should've said it.


text:
San Ysidro swap meet replaced with Goodwill
"Oh yes, we all know it will close at the end of the year."
Marty Graham 3 p.m., Sept. 22
OCT 8 - Got off the blue line trolley downtown and headed for City Hall. Once inside the plaza area I saw a sign that directed me to a park on 1st and G. As I strolled the several blocks to the park a trio of young men fell in behind me.
"Are you going to Occupy?" they asked me.
"Yup," I answered.
"Right on, so are we," came their reply. As we were talking, the park came into view.
The Occupy camp at Childrens Park consisted of tents, tables and placards. Lots and lots of placards. A small hill on one corner of the park was covered in hand written signs of every conceivable cause. By far the majority of the signs were protesting the disparity in wealth that cripples the development of the United States of America these days. However, other issues abounded. Free health care advocates, gay and lesbian rights activists, the socialist party, labor unions... It seemed like everybody with a gripe against Uncle Sam was here.
A media center had been set up where people sat at laptops or fiddled with cameras. The atmosphere was busy in a mellow sort of way. As I walked the entire camp a couple of times, I noticed how many people seemed to be discussing politics and the state of our nation in general. That was what stood out to me on that first day. Childrens Park in San Diego buzzed with small clusters of Americans rapping about democracy. It was a beautiful thing.
As a poli-sci junkie I dug the scene. So I looked for a good place to post up and start taking notes. This park has no benches near its reflecting pool. Just these concrete things that are most uncomfortable. I perched myself as best as I could atop one, lit a sandalwood incense that I pulled from my satchel and started taking notes. After a couple of hours I packed up and left to catch the route 30 to go to work in PB.
OCT 11 - By this time the camp had moved to Civic Center Plaza. From a political statement point of view, I felt that this was a better location. As it was between City Hall and the towering marble altars to the almighty dollar that are the banks on B street.
It was my my third visit to the new location but tonight would be the first night I slept over. On the other occasions I'd merely perused the various clusters of protestors. Not so much seeking an immediate story but rather trying to identify characters and those of character, or best of all, characters with character, amongst the crowd. people that I find interesting. Which makes me want to write about them. I would come to find that Occupy has all of the above and more.
I got off work at 9pm and arrived at the plaza a little after 10. The place was awake and active. I couldn't help but grin when I saw the theater sign on 3rd street.It advertised the musical HAIR. Some in the camp appeared to have come dressed as extras in the play. Wether colorfully attired or not, the general sense that I felt was one of positiveness. People trying to help people for the betterment of mankind. "This place is giving off some good vibes," I thought to myself.
There wasn't a lot of available space to bed down. It took me awhile before I found a spot beside one of the pillars that support the second story walkway. I didn't have a tent, sleeping bag or even a blanket. Just a jacket and a few cigarettes to keep me warm. They didn't help much and by morning I was aching pretty good from the chilly night.
That was when I got to know my neighbors. Those bedded down around me. All of us were lying near a makeshift altar that had been erected for the man who fell from the parking structure a few days earlier. Nearest the candles and flowers was a young couple. Closest to me were two homeless men who I still see to this day. One is named Kenny but I call him "General" because he reminds me of a confederate general. The other is named James but everybody calls him Elvis.
That was when I began to realize how many homeless people were within the Occupy camp. I wondered how many of these were active participants and how many were in the camp for the security it was providing. Street life can be a brutal existance. The numbers rattled me at first but I would soon come to realize that of all the shame that blots 'America's finest tourist trap' it's treatment of the homeless is the cruelest stain of all.
Within five minutes of sharing talk and tobacco with Elvis, I felt comfortable around the man. The General didn't say much. He never does. Just nods. And that was how I passed the early morning of Oct 12 2011 at the Occupy San Diego camp. Just me, Elvis and the General.
END PART ONE "Coffee's Ready, Gotta Go...!!!"


text:
|Tillman, Patricia - Glynn
|Mulrooney, Joseph - Joe
|Snodgrass, Gordon
Submitted to: Journal of Entomological Science
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/1/2002
Publication Date: 3/1/2003
Citation: Tillman, P.G., Mulrooney, J. E., Snodgrass, G. L. 2003. Comparison of susceptibility of Geocoris punctipes and Lygus lineolaris to insecticides for control of the tarnished plant bug. Southwestern Entomologist. 28(1):47-54. Interpretive Summary: The tarnished plant bug is responsible for millions of dollars in costs associated with crop loss and insecticide costs across the US. Since resurgence of key pests and outbreaks of secondary pests can occur with treatments that destroy natural enemies, insecticide selectivity is an important issue in integrated pest management. Thus, the objective of this research was to compare the toxicity of the insecticides Orthene, Bidrin, Karate, Vydate, and Provado to the tarnished plant bug and the big-eyed bug, a predator of this pest. In laboratory tests, the tarnished plant bug was more susceptible to Provado and Vydate than the big-eyed bug. Both insect species responded very similarly to Orthene, Bidrin, and Karate, all of which were very toxic to these insects. In our field study, Karate had an equally negative impact on populations of the tarnished plant bug and the big-eyed bug. Results from our laboratory and other field studies indicate that Vydate and Provado would be effective against the pest while conserving populations of the predator for biological control of pests in cotton.
Technical Abstract: Comparison of the susceptibility of Geocoris punctipes (Say) and the tarnished plant bug (TPB), Lygus lineolaris (Palisot de Beauvois) to selected insecticides was determined in topical, tarsal contact, and field studies. In both topical and tarsal contact studies, L. lineolaris was more susceptible to imidacloprid and oxamyl residues than G. punctipes. Both insect species responded very similarly to fipronil, acephate, dicrotophos, and lambda-cyhalothrin, all of which were very toxic to these insects. In our field study, lambda-cyhalothrin had an equally negative impact on populations of TPB and G. punctipes. Results from our laboratory and other field studies indicate that oxamyl and imidacloprid would be effective against TPB while conserving populations of G. punctipes for biological control of pests in cotton.


text:
Pawn shop owner hopes recent bust doesn't give others a bad rap
CHARLESTON, S.C. (WCIV) -- According to regional supervisor of Money Man Pawn, Mike Bond, the pawn business is heavily regulated by consumer affairs.
The supervisor of 12 Money Man Pawn stores said the bust of Mr. Flap's Pawn in Goose Creek came as a surprise.
Bond said if a pawn shop owner accepts stolen merchandise, eventually they will get caught.
"It's going to catch up with you," he said.
Bond said police should be the first to know whether stolen goods have come into a pawn shop -- if the store is operating under state law.
"If you bring the property in here, you might as well bring it to the police department's door step," Bond said.
Bond said there is daily interaction with local law enforcement. Whether it is a loan or a purchase from an individual, they must log into a system and e-mail those records to the Berkeley County Sheriff's Office. From there, the records are loaded into the National Crime Investigation Center, (NCIC) a national database.
"There are occasions where items may very well come in that are reported stolen and have been taken to one of our locations," Bond said. "If that's the case, we're contacted by local law enforcement and they come in -- usually have victim come down and visually ID the property."
Bond said law enforcement officers conduct audits periodically as well.
"They check paperwork, verifications on models, and serial numbers on all merchandise that comes in here."
Bond also said if they suspect an item brought in was stolen, that the pawn shop will contact law enforcement.
As for, Mr. Flap's alleged shoplifting operation, Bond said he hopes it does not give other pawn shops a bad rap.
"It's unfortunate for businesses that follow the law to be grouped in with other businesses that may not."
Bond said pawn shops are also required by law to check photo identification when someone wants to pawn an item.


text:
The Purdue football coach is gearing up for his second season by maximizing every available advantage. Thanks to a NCAA rules change that allows college football coaches an extra eight hours a week to work with their athletes over the summer, accountability is high on his must-do list.
Yes, Hazell and his staff will use it to enhance strength training, conditioning and teaching — much like they do in the winter. Coaches will meet with freshmen one day a week ("so those guys will get caught up fast," Hazell said) and then meet with the team one day a week to address overall needs.
But if the Boilers are to move up the Big Ten football chain — and you'd better believe that's the goal — it will take more than that.
Thus, the players-as-coaches concept.
"We want them to have kind of an accountability," Hazell says. "There will be players' only meetings where they teach parts of the offense, defense and special teams."
The idea is, if you teach it, you'd better know it, and if you know it, well, good things can happen.
Hazell leaves nothing to chance. Thus this year's program blueprint — "A Player's Manual" — is a man-building 621 pages. He boosts his philosophy with a Leave No Doubt theme.
He wasn't hired to produce Big Ten patsies, as last year's 1-11 team became due to extreme youth and coaching/system transition from the Danny Hope era.
Athletic director Morgan Burke has made it clear he wants a Rose Bowl, which hasn't happened to the Gold & Black since 2001 under then coach Joe Tiller. Hazell fully embraces that. He has an Ohio State championship pedigree and a Kent State turnaround on his resume.
Last year's Purdue debut didn't reflect the program he is building given the Boilers were young as you don't want to be. The result was a 1-11 record that was bad in the short term (Purdue was at or near the Big Ten bottom of nearly every offensive and defensive stat), but potentially beneficial in the long-term given all the experience gained.
"It will pay huge dividends," Hazell says. "You saw it in the spring time. Guys just look so much more comfortable running around.
"There's nothing like experience. There really isn't. If you have talented guys with experience, whether they're young or old, it doesn't matter. If they're talented and experienced, that's a deadly combination."
That combination includes veterans such as safety Landon Feichter (the former Bishop Dwenger standout), running back Raheem Mostert (the Big Ten's fastest football player who won multiple conference sprint titles this spring), center Robert Kugler (last year's team offensive MVP) and quarterback Danny Etling (although last year's freshman starter is battling Austin Appleby and David Blough for the No. 1 spot).
Purdue supplements that with a newcomer class that features four offensive linemen, four defensive backs and three defensive linemen. Three of them — Blough, offensive lineman Kirk Barron and defensive end Langdon Newton — enrolled early last semester. The rest, including highly touted linebacker Gelen Robinson, are now participating in summer workouts.
Does Hazell envision any making instant impact?
"They'll be thrown into the mix pretty quickly (during August preseason camp)," he said. "We'll find out in the first four to five days which guys can help us, whether that's a starting role, a backup role or special teams.
"We have some specific needs. Offensive line was one of them. Linebacker was another. We did sign some corners. Those are the three positions that we'll look at to determine which guys will be on the field."
The 6-2, 230-pound Robinson is an intriguing prospect. The son of former Boiler basketball All-America Glenn Robinson, he was an all-state football player, a two-time state wrestling champion and a field event state titlist at Lake Central High School.
"The thing that he can't do is come in and press," Hazell said. "He's a very gifted player. You watch him run to the ball, and it's instinctual. He's fast. He's physical. He has all the tools to be a good player.
"Again, he can't press. He has to learn the system.
"I told our coaches I don't want good players standing on the sideline. If we have to take a little bit out of the package to get those good players on the field, and if he's one of those good players who emerges quickly, then we have to find a way to get him on the field and not handcuff him with the scheme."
Robinson's multi-sport background is becoming more and more rare in these specialize-in-one-sport times.
"When you when evaluate the tape you watch football ability," Hazell said, "but I think it's a gift to do some of those things he's able to do."


text:
Bad news for churchgoers, at least if you're from the United States — a new study linking obesity with religion has discovered that people who frequently attend church
to become extremely overweight compared to those who attend less often or not at all, according to CNN.
The researchers from Northwestern University's Feinberg School of Medicine, who presented their findings at an American Heart Association conference, surveyed 2,433 people between the ages of 20 and 32 about their dietary habits and cardiovascular risk factors. Twenty-five years later, the subjects were put through the same tests. After analyzing the data, the researchers found a high frequence of obesity among the repondents who said they regularly went to church.
There is no clear correlation between religion and weight gain, but you're probably thinking you have a good idea of what could be the biggest contributing factor — those massive church potlucks.
From CNN's health blog:
"Churches pay more attention to obvious vices like smoking or drinking," said Matthew Feinstein, lead author of the research and fourth-year medical student. "Our best guess about why is that…more frequent participation in church is associated with good works and people may be rewarding themselves with large meals that are more caloric in nature than we would like."
What do you think — does a churchgoing lifestyle lead to obesity later in life? Or is this just another one of those trend stories people love because they can write headlines like, "This is why church makes you fat"? Weigh in (pardon the pun) in the comments below.


text:
BATON ROUGE, La. (AP) – Women in Louisiana seeking an abortion will have to receive a pamphlet that describes possible psychological effects of the procedure, though studies disagree on those effects.
With an 87-0 vote, the House gave final passage Thursday to a bill requiring the information. It also requires women to receive pamphlets about the illegality of coerced abortions and services available to human trafficking victims, before they can have an abortion.
The measure, by Republican Rep. Barry Ivey of Baton Rouge, heads to Gov. Bobby Jindal, who supports it.
Clinics will have to provide the brochures at the start of the state-mandated, 24-hour waiting period before a woman can have an abortion, with an exception in cases of a medical emergency.