text:
Cyclophosphamide Systemic Sclerosis Associated Interstitial Lung Disease (SCLEROCYC)
This study is currently recruiting participants.
Verified August 2016 by Assistance Publique - Hôpitaux de Paris
Assistance Publique - Hôpitaux de Paris
Hôpital Claude-Huriez
Information provided by (Responsible Party):
Assistance Publique - Hôpitaux de Paris
ClinicalTrials.gov Identifier:
First received: April 2, 2012
Last updated: September 14, 2016
Last verified: August 2016
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
By including in this study patients with significant worsening of their lung volumes and / or their DLCO (carbon monoxide diffusing capacity) in the previous year, on the basis of an open retrospective study we recently conducted, we hope to demonstrate that a strategy combining prednisone and intravenous cyclophosphamide therapy is accompanied by an increase in the frequency stabilization / improvement of lung volumes and / or DLCO of patients at 12 months of 15% in the placebo and prednisone cyclophosphamide 50% in cyclophosphamide and prednisone.We also hope to demonstrate significant decrease in the number of patients excluded for failure in the CYC arm as compared to the placebo arm.
|Systemic Sclerosis Scleroderma Interstitial Lung Disease Lung Fibrosis
|Drug: Cyclophosphamide Drug: Placebo
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|Intravenous Cyclophosphamide for the Treatment of Systemic Sclerosis Associated Interstitial Lung Disease
Resource links provided by NLM:
MedlinePlus related topics: Interstitial Lung Diseases Lung Diseases Scleroderma Steroids
Drug Information available for: CyclophosphamideU.S. FDA Resources
Further study details as provided by Assistance Publique - Hôpitaux de Paris:
Primary Outcome Measures:
- Forced vital capacity [ Time Frame: at 12 months ]Forced vital capacity at 12 months
Secondary Outcome Measures:
- Mortality [ Time Frame: at 12 months ]
- Progression free survival [ Time Frame: at 12 months ]Progression free survival
- Carbon monoxide diffusing capacity (DLCO) [ Time Frame: at 12 months ]
- Treatment failure [ Time Frame: at 12 months ]Failure of cyclophosphamide or placebo
- Walk test distance [ Time Frame: at 12 months ]Six minutes walk test distance, O2 desaturation and gradient between maximal and minimal SAO2 during the test
- Dyspnea [ Time Frame: at 12 months ]NYHA (Classification de la New York Heart Association), BDI (Beck Depression Inventory) and Borg index
- Health Assessment Questionnaire [ Time Frame: at 12 months ]
- Quality of life [ Time Frame: at 12 months ]Saint-Georges; SF-36
- Chest CT (computed tomography) scan [ Time Frame: at 12 months ]CT (computed tomography) scan abnormalities
|Estimated Enrollment:
|Study Start Date:
|January 2013
|Estimated Study Completion Date:
|October 2018
|Estimated Primary Completion Date:
|April 2018 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Cyclophosphamide
Prednisone 15 mg/d + monthly pulse cyclophosphamide 700 mg/m ² diminished to 600 mg/m ² in patients over 65 years or having a creatinine clearance lower than 30 ml/min for 12 months.
Drug: Cyclophosphamide
Prednisone 15 mg/d + monthly pulse cyclophosphamide 700 mg/m ² diminished to 600 mg/m ² in patients over 65 years or having a creatinine clearance lower than 30 ml/min for 12 months.
Placebo Comparator: Placebo
Prednisone 15 mg/d + monthly pulse of placebo of cyclophosphamide. The posology and the methods of administration of the placebo of cyclophosphamide (NaCl) will be the same as those used for cyclophosphamide
Drug: Placebo
Prednisone 15 mg/d + monthly pulse of placebo of cyclophosphamide. The posology and the methods of administration of the placebo of cyclophosphamide (NaCl) will be the same as those used for cyclophosphamide
Detailed Description:
This is a randomized prospective multicenter study evaluating the efficacy against placebo of cyclophosphamide in combination with prednisone in the treatment of systemic sclerosis related interstitial lung disease. Patients will be allocated, after randomization into two groups receiving both corticosteroids: a group of patients receiving placebo of cyclophosphamide and a group of patients treated with cyclophosphamide. Cyclophosphamide will be administered IV at a dose of 0.7 g / m (maximum 1200 mg) every 4 weeks. In patients over 65 or if the creatinine clearance below 30 ml / min the dose should be reduced to 0.6 g / m². The duration of treatment with cyclophosphamide will be 12 months.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age ≥ 18 years old
- Signed informed consent
- Patient with systemic sclerosis fulfilling the ACR -American college of rheumatology - (Masi et al. 1980) and/or Leroy and Medsger (LeRoy and Medsger 2001) diagnostics criteria with worsening ILD (interstitial lung disease) identified on a high resolution chest CT scan and by worsening of forced vital capacity (FVC) and/or total lung capacity (TLC) ≥10% and/or worsening of DLCO ≥ 15% as compared to values obtained within the 3 to 18 months preceding inclusion (for DLCO, in the absence of pulmonary arterial hypertension upon echocardiography)
- Smokers may be included (DLCO must be performed at least 72h after stopping tobacco intake).
- Patients with pulmonary hypertension (mean pulmonary arterial pressure <35 mmHg upon right heart catheterisation) secondary to hypoxia due to pulmonary fibrosis will also be included into the study.
- Physical examination prior to inclusion into the study (results must be given to the patient).
- Effective contraception for women of childbearing age(negative pregnancy test at baseline)
- Membership of a social security scheme
Exclusion Criteria:
- Prednisone prescribed a dose greater than 15 mg/d during the last 3 months.
- Scleroderma renal crisis or acute or critical limb ischemia within the last 3 months,
- Left ventricular ejection fraction below 40% evaluated by echocardiography.
- Out of proportion pulmonary hypertension (mean pulmonary artery pressure above 35 mmHg upon right heart catheterization).
- CYC treatment during the last 12 months.
- Allergy, hypersensitivity or documented adverse events or contra-indications to the drugs used in the study (cyclophosphamide, Uromitexan, corticosteroids, domperidone ...)
- Patients with a past history of cancer within four years before inclusion and/or a history of chemotherapy for cancer within four years before inclusion (in remission or without disease activity for more than four years)
- Severe infection: sepsis, cellulitis, gangrene in the last three months
- Past history of cystitis related to cyclophosphamide treatment
- Association to another connective disease : systemic lupus erythematosus, syndrome of Gougerot-Sjögren with anti-SSA/SSB, mixed connective tissue disease
- Patient pregnant, lactating or not using contraception considered effective by the investigator (abstinence and / or oral contraception or mechanical)
- Patient in childbearing, refusing contraception
- Failure to sign the informed consent or unable to consent-Patient participating in another clinical trial
- Injection of Rituximab within 6 months preceding inclusion
- Methotrexate or Cellcept treatment at inclusion
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01570764
Please refer to this study by its ClinicalTrials.gov identifier: NCT01570764
|Contact: Luc Mouthon, MD, PhD
|Contact: Laurence Lecomte, PhD
|Cochin Hospital
|Paris, France, 75014
|Contact: Luc Mouthon, MD, PhD ++33158412031 email@example.com
|Principal Investigator: Luc Mouthon, MD, PhD
Sponsors and Collaborators
Assistance Publique - Hôpitaux de Paris
Hôpital Claude-Huriez
|Principal Investigator:
|Luc Mouthon, MD, PhD
|Cochin Hospital
More Information
Keywords provided by Assistance Publique - Hôpitaux de Paris:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Assistance Publique - Hôpitaux de Paris
|ClinicalTrials.gov Identifier:
|NCT01570764 History of Changes
|Other Study ID Numbers:
2011-004709-26 ( EudraCT Number )
|Study First Received:
|April 2, 2012
|Last Updated:
|September 14, 2016
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
Keywords provided by Assistance Publique - Hôpitaux de Paris:
Systemic sclerosis
Interstitial lung disease
Additional relevant MeSH terms:
Lung Diseases
Scleroderma, Systemic
Scleroderma, Diffuse
Lung Diseases, Interstitial
Pulmonary Fibrosis
Pathologic Processes
Respiratory Tract Diseases
Connective Tissue Diseases
Skin Diseases
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Antirheumatic Agents
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Myeloablative Agonists
Anti-Inflammatory Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Antineoplastic Agents, Hormonal
ClinicalTrials.gov processed this record on September 21, 2017


text: Hi all, I woke this AM and had a msg from VM on my phone. Something about the network upgrade was complete and the new T&C was now in effect. I closed the message but now I have zero data connectivity. Its as if I have been switched off from the network. I usually get decent 4g bit now get a "Error 67 - No data connection". Very strange seeing as I have never had a data error in 6 months. Im S-Off, Harmonia and performed the forums "Update" for the radio about 2 months ago. Any ideas? Thanks all.

subset: commoncrawl


text:
Kristaps Porzingis says Carmelo Anthony refers to himself as 'Me7o'
When Carmelo Anthony was traded to the Knicks in 2011, he had to switch his jersey number from the one he wore in college and seven seasons with the Nuggets, but he seems to be embracing his new No. 7.
Knicks rookie Kristaps Porzingis told Bleacher Report that Anthony welcomed him after the draft and identified himself with a numerical nickname.
"Carmelo Anthony reached out to me after I got drafted," Porzingis said. "He said, 'Congrats, welcome to the team.' I didn't have his number, so I texted back, 'Who's this?' And then a few minutes later, he said, 'This is Melo' with his No. 7 as the L."
Welcome to New York, Krist46s.
- Dan Gartland


text:
TAMPA, Fla. — The last four years have been trying and troubling for the United States and it's time for a new course, Chairman of the Republican National Committee Reince Priebus said Tuesday night at the Republican National Convention in Tampa, Fla.
Priebus began his speech Tuesday by praising Mitt Romney as a family man and a business man who saved the Olympics in 2002 and cut taxes and created jobs as the governor of Massachusetts.
A true leader is humble and focused on getting the job done, Priebus said, and that's who Romney is. He also praised Paul Ryan, Romney's choice for vice president, saying he is a man of "true integrity" who doesn't descend into "gutter politics."
Besides, Priebus joked, "Won't it be nice to have a second-in-command who can spend his days doing more than just prying his foot out of his mouth?"
With 23 million Americans out of work, 42 months of unemployment over 8 percent and the worst jobs situation since the Great Depression, it's time to elect Mitt Romney so we can get moving on the great American comeback, Priebus said.
"No parent in America, Democrat or Republican, wants the negative glass-empty view of America that President Obama is trying to sell," Priebus said. "Four years ago Obama was an unproven leader. Today, he's proven himself. He's proven that he's not up for the job.


text:
Governor Walker Tours Wisconsin Institutes for Medical Research
Media Inquiries
Learn More
Wisconsin Institutes for Medical Research (WIMR)
Follow UsUWSMPH on Flickr
Madison, Wisconsin - Governor Scott Walker toured the Wisconsin Institutes for Medical Research Wednesday, July 3, talking and shaking hands with researchers and physicians.
The budget bill he signed on Sunday slated significant funding for key projects at the University of Wisconsin School of Medicine and Public Health (SMPH) and Carbone Cancer Center, as well as some more general funding for health care.
"When Governor Walker signed the biennium budget bill, he reconfirmed his commitment to an enhanced partnership to address physician workforce shortages and to extend access to the most sophisticated clinical imaging services for cancer patients in underserved areas of the state," said Dr. Robert Golden, dean of the UW SMPH and UW-Madison vice chancellor for medical affairs.
The specific budget provisions Walker mentioned include matching funding for a project at the UW Carbone Cancer Center that will provide access to molecular imaging services for cancer patients in 17 oncology care sites throughout the state. The state budget also includes additional support for the Wisconsin Academy for Rural Medicine to place more medical professionals in rural areas of Wisconsin.
"Buildings are wonderful and new technologies are wonderful, but they're only as good as the people who are in them, so we appreciate what [the SMPH] is doing," said Walker. "As Dr. Golden mentioned, we talked a lot about workforce development, and rightfully so. In total there's about $100 million in this budget that in a variety of ways deal with workforce development. One of the key areas in our state where there continues to be a need, particularly in rural areas and highly impoverished areas … is a need for medical professionals."
The state budget also included additional resources for hospitals and health care providers and $30 million for mental health services.
"We want to care for individuals in every part of the state when it comes to mental health care services as well. Whether it's battling cancer or fixing a bum knee or depression or whatever issue there is, we want to break down the barriers that are before us so that every one of those things is a part of good access to health care and is affordable and accessible to everyone in Wisconsin," said Walker.
Date Published: 07/03/2013


text: Pocahontas Solid Waste Authority sues 400 residents over 'green box' fee By David Gutman June 9, 2013 Story Share CHARLESTON, W.Va. -- In the past six years, the Pocahontas County Solid Waste Authority has sued more than 400 county residents, about 5 percent of the entire county, for not paying fees associated with the county's unique "green box" trash program.And those fees, based on local regulations, appear to be in conflict with state code.Among those who have been sued are a current board member of the Solid Waste Authority and the former president of the board.Like many rural counties, trash collection is limited in Pocahontas County, there is only one collection company, Allegheny Disposal, and it is primarily used by businesses.Almost everyone who doesn't hire Allegheny Disposal is required to pay a $98 annual fee for the privilege of using the "green boxes," collection sites throughout the county where residents can drop off trash.That fee applies to everybody with property in Pocahontas County, even those who stay in the county as little as one night a year and produce no trash.Every other county that has similar drop off locations charges by the amount of trash that residents drop off, not a flat fee. Doug Bernier, the board member who was sued by the Solid Waste Authority, said that the flat fee system offers no incentive for people to cut down on their trash and recycle, and instead makes the landfill the de facto first choice."The fellow who hauls a pickup load of trash to the green boxes every week is paying the same fee as the widow who might take a little bag every two months," Bernier said. "Compared to counties that don't have landfills, or ones in more metropolitan areas, $98 per year is a bargain. It is a very expensive proposition to operate a landfill. It's expensive to bury all this trash, which is all the more reason to bury as little of it as possible."West Virginia code says that all residents need to either pay a garbage collection fee or prove that they dispose of their trash "at least once within every thirty-day period at approved solid waste facilities or in any other lawful manner."The Pocahontas County Solid Waste Authority will waive the annual fee if residents can prove that they drop their trash off at the landfill on the free drop off day, the last Tuesday of each month. But miss just one Tuesday, and residents are back on the hook for the $98 fee. And county residents say that the Solid Waste Authority is not letting them dispose of their trash in "any other lawful manner," as mandated by state code.Jerry Heinemann, a county resident, was sued for not paying the green box fees, but he says that he disposes of all his trash in a lawful manner, and should not have to pay for the green boxes that he doesn't use.In a sworn affidavit in Pocahontas County Circuit Court, Heinemann says that he takes glass recyclables to the Greenbrier County Recycling Center, he sells metal recyclables to the center in Elkins, he takes plastic to the recycling center at the Walmart in Elkins, he uses paper and cardboard to start his wood stove and he composts all table scraps.It seems unlikely that the hundreds of residents sued for not paying their fees are as conscientious about their trash as Heinemann, but that doesn't necessarily mean that they weren't disposing of their trash in a "lawful manner." Many of those who were sued are not full time Pocahontas County residents and carry their trash out with them when they leave."If you live in Charleston and have a camp here and you stay here one night you have to pay the yearly fee," Heinemann said. "They say you can't take your potato chip bags back with you."Mary Clendenen, the administrator for the Solid Waste Authority, said that the fee is assessed to every building in the county, regardless of who lives there."Our solid waste assessment fee is an annual fee for each structure or shelter in which a person spends one or more nights per year," Clendenen said.She said that the majority of residents pay on time, but when people don't pay they have to collect through the courts.Bernier said that despite his position on the Solid Waste Authority board, he's basically been outvoted when it comes to the flat fee on all residents for trash disposal. "This system works well for the majority of the people in the county," Bernier said. "The county's probably cleaner than it was 20 years ago, less trash going over the hill, fewer illegal dumps; but that doesn't make the system lawful."Reach David Gutman at firstname.lastname@example.com or 304-348-5119. Story Share Story Share Trending Now 1 Nitro police captain fired over off-duty confrontation caught on video 2 WV Gov. Justice appoints Foster's replacement to House 3 WVU notebook: Holgorsen says injured players 'close' 4 Vintage West Virginia: Putnam Village 5 Malfunctioning aircraft lands safely at Yeager Airport Special Olympians enjoy camraderie, competition Previous Story Concussion law could do more, advocate says Next Story


text:
How to Sell More by Working Less "Come in early. Stay late. Do whatever it takes to succeed." How many times have you heard that? I know I've heard it plenty of times, and every time it was from an unqualified sales manager, who was promoted to management, ironically, because he couldn't sell and the…Read more
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text:
Pages tagged with Traffic Light
This describes the current traffic situation in Bangkok, the major traffic problems and the best solutions.
There are really many ways to generate revenue from something as undemanding and comfortable as the Internet.
What are my rights as a driver? How to properly stop at a red light. What constitutes running a red light? How do the Police determine if a driver has ran a red light? This article will provide you with valuable information and safety tips and answers to these questions.


text:
West Chester, Pa. -- QVC has appointed Ted Jastrzebski to the position of CFO. Jastrzebski, who will assume his new role in July 2013, will oversee QVC's financial operations, reporting to Mike George, president and CEO of QVC. He spent the last eight years in global leadership positions at The Hershey Company, most recently serving as senior VP and president of Hershey Americas.
"Ted is a great addition to the QVC team," said George. "With more than 20 years of business and financial leadership experience, he will be an impactful addition to QVC's already-strong leadership bench. We look forward to leveraging his extensive multi-national expertise as we continue to implement our global growth strategy."


text:
FORT MYERS, Fla. -- Ten measly bucks, and you could have watched Jason Giambi homer against the Sox last night.
Your mother, father, sister, aunt, and uncle could have come, too. That's how many tickets could be had, for face value or less, in a 10-foot radius of sidewalk outside City of Palms Park at 7:05 last night. Inside, Abe Alvarez was throwing the first pitch of the first meeting between the Red Sox and Yankees since Johnny Damon and his disciples brought deliverance last October.
One dejected man slumped in a chair in front of the box office. He refused to give his name, saying only that he'd give anything to sell his tickets at face value ($21 apiece). A year ago, tickets for the inaugural spring game between these adversaries sold for up to $500.
Evidently, the hype was just too much this time. The Yankees prevailed, 9-2, before a crowd of 7,723, halting their winless skid at nine games (four straight in the American League Championship Series, then an 0-4-1 beginning to spring training). Giambi, who is expected to be a landing strip for fan venom, was showered with boos, but it was hardly a downpour.
Asked whether Giambi has been booed more or less than expected, Bernie Williams said, "It's very early to say."
Someone near the field held a sign that read "Got Milk?" with the word "Milk" scratched out and "Juice" inserted. But Giambi showed a flash of his natural talent in the top of the fifth, cranking an 0-and-1 pitch from John Halama over the fence in center, just to the right of the 410-foot sign, for his first home run of this trying spring.
"That's why he's a pro," said David Ortiz. "Everybody knows he admitted it and he's not using anything and he still hit the ball like that.
"Giambi be fine, man. People have to give my man a chance. He's a good kid. He say what he say to get it over with. I think he deserves an opportunity to be out there without people getting on him."
Joe Torre wasn't obliged to bring Giambi here. The Yankee skipper was required by Major League Baseball to bring any four regulars, not necessarily the one who admitted steroid use to a federal grand jury and apologized publicly for his mistake. But Torre did bring Giambi, along with Williams, Hideki Matsui, Ruben Sierra (who was scratched from the lineup), and Tony Womack for the two-hour drive down I-75.
Giambi came to bat five times. He singled sharply to right in the first, flied to shortstop Edgar Renteria in the third, homered in the fifth, was rung up on a breaking ball in the seventh, and grounded to short in the ninth.
Matsui, a nightmare for Boston last October, pounded a double to right-center in his first at-bat and lost a Kris Wilson fastball in the palm trees in right for a 7-2 lead in the eighth.
Alvarez, a lefthander with one career major league start, pitched two innings, going through the Yankee lineup once. He allowed two runs on four hits and a walk, taking the loss. Sox manager Terry Francona, who called up Alvarez for one start last season, gave the ball to the 22-year-old to measure his poise and expedite his development.
"I know his hat's crooked, but he's a pretty sharp young man," Francona said. "I know it's a spring training game, but it's the Yankees, it's a night game. Hopefully he'll grow from it. That's what we want."
The Sox, who played five starters -- Renteria, Ortiz, Trot Nixon, Kevin Millar, and Mark Bellhorn -- couldn't score until the fourth. Nixon accounted for that first run with a first-pitch home run off lefthander -- yes, lefthander -- Alex Graman.
Not earth-shattering stuff, but Graman is a 6-foot-4-incher with solid Triple A credentials (11-6, 3.37 ERA at Columbus last season). Francona has said Nixon will not play Opening Night against Randy Johnson, given that Nixon is a .213 hitter against lefties (.293 vs. righties) and has hit just nine of his 112 homers against lefties.
His mind won't be changed.
"Not on Opening Day," Francona said. "That wouldn't make a lot of sense to me. As I've said, it's not a strict platoon."
In the end, this was just another spring training game, albeit one with 225 credentialed media, 25 fewer than last March 7 when these teams met.
There was very little trash talk. No one asked Alvarez if there was an ulterior motive to his postgame clothing: a black T-shirt with "Public Enemy" splayed across the front.
"Why people make such a big deal about this game, man?" Ortiz asked. "This doesn't mean [expletive]."
Except, that for the first time, the Yankees had to face Sox media and address an offseason of suffering.
"You can dissect the game so many ways, what went wrong, what should have happened, and could have happened," Williams said. "At the end of the day you look at the result that wasn't the result you wanted. You try to leave it alone and turn the page."
But, it's a lesson learned.
"It has to be to some extent," Williams said, "so it reminds you."


text:
U.S. v Skoien: A review standard for Heller?
View Single Post
November 19, 2009, 08:13 AM
Bartholomew Roberts
Senior Member
Join Date: June 12, 2000
Location: Texas and Oklahoma area
Posts: 6,782
Wait a minute, isn't this one of the same circuits that wouldn't acknowledge incorporation? Unless I'm mistaken about that, how can they rely on Heller?
The law Skoien was convicted of breaking is a federal law and not a state law (18 USC 922(g)(9)), so the incorporation issue isn't relevant to this case.
Haven't been able to read the decision yet with everything else that is going on; but the parts Tom Servo has quoted are certainly interesting.
The implication that strict scrutiny does not imply to non-defensive firearms is interesting both in that the standard that does apply is still relatively strict and of course because it suggests that defensive firearms DO enjoy a strict scrutiny standard. It should be a very interesting case.
The cases (and progress) are starting to come quicker and quicker now... especially for those of us who remember the 1990s where a groundbreaking case was something like Thompson Centerfire Contender (which is still basically ignored by ATF) and only came once a decade.
Bartholomew Roberts
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text:
found a new home!
Plenty of my friends are looking
for one too. Find a pet to adopt.
I am already spayed, up to date with shots, and good with dogs.
maggie, a Goleta Pomeranian/Chihuahua dog was adopted! Here's how you can benefit by looking at adoption as an option to buying a Pomeranian/Chihuahua for sale in Goleta, or seeking a Pomeranian/Chihuahua dog from a breeder in Goleta.


text:
hi priscilla,
i understand the frustration of constant medical complaints.
i had my problems for 30 years before i was diagnosed.
since being diagnosed,i have had to give up work, and re-evaluate what was really important to me.
i went bankrupt and lost everything.
i now rent a quiet house on a farm.
life is very good to me now.
we all need to find our balance.
mine meant giving up the stress of work.
i hope you can find your balance.
please read a few of the older posts......
they are our personal experiences with lupus.
again welcome.


text: Otter Tail Q2 Profit Beats Estimates - Quick Facts 8/4/2014 6:32 PM ET Otter Tail Corp. (OTTR) reported that its second-quarter income from continuing operations increased to $10.0 million or $0.27 per share, from $7.5 million or $0.21 per share, prior year. Analysts polled by Thomson Reuters expected the company to report profit per share of $0.23 for the quarter. Analysts' estimates typically exclude special items. Revenues were $234.6 million compared to $212.4 million, a year ago. Analysts expected revenue of $221.20 million for the quarter. The corporation narrowed its 2014 earnings guidance range to $1.65 to $1.80 per share, from previously announced range of $1.60 to $1.80, based on its strong performance in the first half of 2014. Analysts expect company to report 2014 profit per share of $1.73. by RTT Staff WriterFor comments and feedback: email@example.com News America's 10 Worst Cities to Retire Keep An Eye On These 9 Biotech Stocks This Month Pharma Stocks That Grabbed Headlines This Week


text:
Ciara Dropped from Jive Records?
There's a rumor going around that Ciara has been dropped from her label, Jive, because of poor sales of her latest album "Basic Instinct." The website sandrarose.com reported her single "Turn it Up" has been removed from the release list, and went on to say that Ciara could be in talks with Interscope Records. There's also some pretty harsh words about Ciara as well, that she has become a "drain on label resources" and hasn't been able to find her genre or voice. Other reports saying Ciara will deny that she has been dropped and an official announcement could come next week.


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A MOTORIST who damaged another vehicle while parking has urged the owner of the car to get in touch.
The woman, who asked not to be identified, knocked the wing mirror off a vehicle while pulling into a space at the Park Place car park in Darlington on Thursday, January 16.
The incident happened at about 7.20pm.
The woman said she could not stop at the time but intended to leave a note or speak for the owner later.
She added: "We were rushing off to the theatre and I thought the vehicle would still be there when I got back and I could sort it out then, but I got back and it was gone.
"I feel so guilty. I want to repair for the car to be fixed."
If this was your vehicle, email firstname.lastname@example.com to be put in touch with the motorist.


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Fri 8th Mar at 8:00pm
Tiny Dragons
@ Latest Music Bar, Brighton
Also appearing: Tarq Bowen, Johnson & The Believers
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EP Launch Night: Tiny Dragons + Tarq Bowen + Johnson & The Believers
After having toured the UK and played shows in Europe, Tiny Dragons return to Brighton for a one off headline special in support of their brand new 4 track EP released March 2013.
They promise to fill the walls of The Latest Music Bar with their mammoth live sound and presence!
Tiny Dragons
A three piece band from Brighton playing a powerful mix of dance, soul and alternative music.
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Acoustic singer-songwriter, forging a sound which takes in folk, country and blues, with a style and delivery which has invited comparisons with Tim Buckley and Jim Morrison. Tarq Bowen is a fast emerging talent. His energy-defying one-man live set-up, aided by a self-crafted stomp box and appearances from harmonica and tambourine, together with some beautifully precise and lyrical slide guitar, is a live act not to be missed.
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→ Brighton 12 min walk


text: No recent wiki edits to this page. Power Girl enters the Darkworld, intent to defeat the Weaver, a Lord of Chaos and an enemy of her grandfather Arion. She meets a creature named Ghy, who allows her to breach the wall separating our realm and Darkworld. Once in Darkworld, she faces all of her nightmares come true: her friends turning against her, her original parents Zor-El and Allura fading from memory, and her grandfather Arion disowning her. In the end, she becomes a captive of the Weaver. Power Girl breaks out of the Weaver's web, but is attacked by her long-lost brother Khater. Khater is also a grandchild of Arion, but was thought lost with the sinking of Atlantis. The Weaver begins warping the fabric of Darkworld, again attacking Power Girl's insecurities. However, Power Girl uses her lessons taught to her by her karate instructor "Mongo" Krebs to not give into her fears. She renews her attack, and with Ghy's help, defeats the Weaver. Power Girl is teleported home, where the Phantom Stranger waits for her. The Stranger explains that Power Girl is now in the middle of the fight between the Lords of Order and Chaos, and that she must help warn the other heroes of Earth.


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Careers @ Ytel
PHP Developer
We're a software company with a passion to help businesses better communicate with leads, prospects and customers. We geek out over the challenges of telecom and deliver cutting edge, cloud-based communications solutions. As a full-service carrier, with a company owned network, Ytel truly offers a one-of-a-kind solution. Over the years we've been able to provide cost effective, secure ways to power modern communications through voice, text, email and direct mail.
We need someone with a passion for technology, who gets excited about the idea of leaving their fingerprints on change.
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A trial against a former West Sacramento police officer accused of rape and a number of other charges is expected to take at least two weeks.
But it will be at least two more weeks before the public knows the date of the trial for Sergio Alvarez. A trial hearing conference was continued Friday until Tuesday, April 9.
Alvarez pleaded not guilty on March 7 to charges of kidnapping, sexual penetration, oral copulation and sodomy against the victims' will. He waived the right to a trial within 60 days at that hearing.
"We need time to confer with our experts to get a meaningful trial date," said Gabriel Quinnan, Alvarez's lawyer.
Supervising Deputy District Attorney Garrett Hamilton agreed and said he doesn't want to set a trial date "unless it's going to stay" with a number of civilian witnesses who will be testifying.
Judge Dave Rosenberg asked how many days the trial will take and Hamilton responded between "12 to 15 court days."
After the last hearing, Quinnan had been expected to file a request for a bail hearing. Quinnan had no comment Friday on that request with Alvarez's bail remaining at $26.3 million.
A uniformed patrol officer who worked alone during the night shift, Alvarez allegedly coerced his victims into sex by "threatening to use his authority as a public official to arrest and/or incarcerate" them, according to an indictment filed against him. The alleged assaults were said to take place between Oct. 1, 2011 and Sept. 23, 2012, with some occurring in his patrol car and others in an undisclosed location.
West Sacramento police say one victim told another officer she had been assaulted, sparking a five-month investigation conducted jointly by the Sacramento and West Sacramento police departments. That investigation wrapped up in late February and Alvarez was fired and arrested.
Follow Katherine Jarvis at twitter.com/katherinejarvis


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The factory LADA Sport team prepares to bid farewell to the 110 model in its final race in the WTCC
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The LADA Sport team will bid farewell to the 110 model it has used since entering the World Touring Car Championship this weekend in the final outing for the car before it is replaced by the Priora in Portugal.
The 110 made its debut in the WTCC last season with the Russian Bears Motorsport team and has continued into this campaign as work continues on preparing the Priora for its race debut.
Jaap van Lagen, Kirill Ladygin and Viktor Shapovalov will again be on driving duties in the three cars this weekend, with the trio hoping to make the most of continued development of the engine which should boost both power and straight line speed.
"Brno is a fantastic circuit and there is always a great atmosphere there," van Lagen said. "We had some interesting evolutions on the car already for the last round in Spain and while they seemed promising, circumstances dictated that we could not really use them to their full potential. Hopefully in Brno we will be able to have a clean run and really see their full effect."
van Lagen in particular showed the potential of the new engine last time out in Spain despite a number of mechanical issues, and team principal Shapovalov admitted that the potential was there with the improved engine, even if the reliability isn't.
"We've been impressed by the speed that the latest engine modifications on the car have given us but it's clear that we need to work harder on reliability,"? he said. "This weekend on such a challenging track will be the perfect opportunity for us to assess the progress we have made so far, as we look forward to the debut of our new car in Portugal. The potential is clear to see, but we need to keep working very hard in order to succeed."


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Helping clients quickly anticipate and react to business and market changes through the adoption of an intelligent infrastructure, Accenture (NYSE:ACN) is increasing the cognitive automation capabilities of its IT Services delivery by collaborating with IPsoft, a leading provider of autonomic IT services. Under an agreement with Accenture, IPsoft's technology will be used to enhance the automation of infrastructure operations across compute, network and storage devices to help minimize manual intervention and improve service quality. By integrating IPsoft's IPcenter solution into its IT Services delivery toolset, Accenture will help clients improve the efficiency of their operations, by increasing the speed, agility, quality and consistency of incident responses, while lowering service costs. Today's IT infrastructures are being strained to the breaking point by new digital technologies and applications. The potential business implications from service disruptions are more significant than ever: inability to serve customers effectively, supply chain delays, slower product development and compromised security. Organizations can address this challenge by creating an intelligent infrastructure – one that can learn, predict, automate, adapt, protect and even self-heal across the data center, network, workplace, security and operations. This increased agility will allow organizations to create greater business value and competitive advantage. "Automation and orchestration are important components in building an intelligent infrastructure that is flexible enough to anticipate and react to changes more quickly," said Jack Sepple, senior managing director for Accenture's Infrastructure Services practice. "The combination of IPsoft and Accenture working together will benefit our clients as they begin the journey towards an Intelligent Infrastructure. We will enhance our foundational IT Services delivery and help our clients create a dynamic, agile infrastructure that balances current workloads and efficiently handles future demands." "IPsoft's autonomic platform coupled with Accenture's extensive knowledge of technology and business process change will allow enterprises to begin transforming their infrastructure into intelligent, self-governing IT operations. Our shared objective is to help our clients rewrite the cost/quality equation through autonomic processes. We are making possible new levels of efficiency which cannot be achieved through conventional, labor-intensive operations management," said Chetan Dube, CEO of IPsoft.
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Credits page with indicia in black on a white background.
24 letters of comment by Robert Kirkman, Benjamin T. Wade, Bobbie Zappelli, Brent Engstrom, Ken Lindgren, Sean Kiley, Sean McGovern, Jeremy Hancock, Matt Irvin, Bobbie Zappelli, Michael DiGiovanni, Olav Beemer, Kris Hunter, George T. Singley IV, Rob Osborne, Joe Novak, Dan Morris, Ben Herman, Justin Crouse, Gary Lau, Barry S. Goldberg, Augie De Blieck, Jr., Adam Levine, Amy Walker.
Pin-up by Erik Larsen's son, age 6.
4 Black & White-Funny-strips.
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Google+ Readies for Third-Party App IntegrationVootie (1598 pencils) | Fri, 2012-04-13 15:06
Or at least that would seem to be the message being sent out by its just-launched redesign. Facebook visits in the US have fallen in the last year, so with the increased engagement that app integration brings, Google+ might still find traction. But is it enough to make us love it? For most of us, not quite yet.
Commenting on this Blog entry will be automatically closed on June 8, 2012.
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G+ is just too complicated for the average user, and for the sophisticated user, the tie-ins with all of Google's products is just too much in the way of privacy and nuisance.
Too bad, because it's a great looking product with potential. I just think it's too much work deciding what I see, who I share with, and building circles...
Visit The Graphic Mac for graphics and Mac OS tips, reviews, tutorials and discussion.
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According to me G+ is much backward than the other social networking communities. Still it needs to be developed more. But today when i checked, It was strange but good. I think it needs some more updates.
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text:
Ask the MisFits
Tuesday, June 17, 2008; 11:00 AM
He's a veteran reporter, digging up the latest fitness news. She's an irreverent columnist with a knack for getting people off the couch and into the gym. Together, they're here to handle your worst work-out dilemmas and exercise questions.
Vicky Hallett and Howard Schneider are the MisFits, The Post's fitness writers.
The transcript follows
Howard Schneider: Did everyone stumble to work in their sandals and high heels today, or take my advice and wear some sensible ZZ Top shoes? Keep in mind it is prime walking season -- so don't crimp your style with footwear that can hurt you, regardless of how it affects your sense of style.
Anbody do anything fun this weekend? I went out with some biking friends for the first time in a while, and it reminded me how refreshing it is to switch up the program. After a few months of focusing on running it was nice to take a break and do something else. So, if you are feeling bored with what you're doing, try something different -- a new sport, a new activity, a new class, anything to break the mold.
Vicky Hallett: And feel free to make fun of Howard for going to the Sex and the City movie for "column research." I know I have...
Bethesda, Md.: I'm submitting early as I will be exercising during the chat (which I read almost every week). Since you were talking today about how bad high heeled shoes are, do you or anyone else have suggestions for high heeled shoes that aren't QUITE so bad -- ones that I could wear for a few hours once or twice a week? I don't need shoes to wear all day, just for special outings. Are there particular stores or shoe brands I should look for? I will be going back to my podiatrist soon, but the shoes he sells are all flats. Thanks!
Howard Schneider: Enjoy your workout Bethesda and we are jumping right on your question in honor of your early filing. The issue with heels is all about the angle and what that does to the way your leg, ankle and foot interact as you move. It is a complicated set of movements that are engineered to happen a certain way. The problems outlined in many studies and by groups like the Mayo Clinic are chronic ones, associated with extended use -- kind of like any overuse injury. One of the researchers who wrote the studies mentioned in today's column would probably agree that wearing heels once or twice a week for limited periods of time probably would not be much of a risk...just don't live your life in them like those crazy SITC characters.
Vicky Hallett: I know Howard is the world's top authority on high heels, but I'll jump in here, too...
Do you know about Taryn Rose (Tarynrose.com)? The line was developed by an orthopedic surgeon. Ecco (Eccousa.com) is another brand you might want to look at. Privo (Privo.zappos.com) also has some attractive, comfortable shoes, although not many have a heel -- probably for good reason. But I just looked over their site and there are a few cute wedge sandals.
Silver Spring, Md.: I am interested in purchasing an elliptical trainer for my personal use. I have been trying to read online about the different brands but haven't been able to come up with any kind of a consensus between the websites as to which is a good buy. My budget is between $500-$1000. Do you have any recommendations? Thanks so much.
Vicky Hallett: While I know which models I gravitate toward at the gym, those are way too fancy for home use (and definitely out of your price range). Any chatters out there want to share their consumer reports?
Drenching wet: I sweat a lot when I run. A lot. I drink plenty of water before, during, and after a run so I'm not worried about dehydration but I am curious. What does it mean when your body sweats so much? How can other people workout without sweating at all?
Vicky Hallett: A few weeks ago, someone on the chat said that the more accustomed your body is to exercise, the more it sweats. I still have no clue if this is true, but I know I sweat a lot. So maybe that's why? But all you really need to know is that sweat is a factor of the environment where you're exercising, what you're wearing and the workings of your body's personal cooling system. Some things you can change, others you can't. And drinking a lot of water is good.
If you were exercising vigorously and not sweating, well, I'd be more worried...
Howard Schneider: It's a badge of honor in my book -- it means things are working as they should. Now, if you find yourself drenched when you're not exercising, like sitting around behind your desk, then you might want to check with a doc. But if it is during a run or other intense exercise, it is just your body keeping itself cool.
Sass in Arlington: Good morning Misfits! I have a shoe-related question for you today.I am somewhat confused about pronation and underpronation/supination. I have very high arches, but I think I tend to pronate rather than underpronate, as would normally be indicated by my foot shape. My shoes wear almost exclusively on the inner edge, along the balls of the feet, at the big toes and a bit on the inside of the heels. So, should I buy shoes made for people with high arches, which assume underpronation, or for people with flat feet, which are built for pronators? Or am I just misunderstanding the entire issue?
Vicky Hallett: Hey there Sass, I'm baffled by your shoe wear too! You sound like a candidate for an in-person gait analysis, and luckily, there are a bunch of stores around you that could help you out (the Clarendon Pacers, Gotta Run at Pentagon Row, The Running Company in Georgetown). It's usually recommended to bring in your old shoes for the test, and in your case, I'd say it's required. Let us know what you find out.
Charlottesville, Va.: I'm just starting to train for my very first marathon because I got a spot in the NYC marathon this fall! I have run three half marathons in the past. My goal is to finish. I'm wondering if I can just slog out the miles for my training as opposed to doing speed/tempo training, too. What would you recommend for a first timer? Thanks!!
Howard Schneider: Yes you could slog through the miles and finish. You could also walk. I guess my thinking is, if you've got the spot and are going to put in the time, why not do the extra bit of work needed to do your best? The speed and tempo workouts will help your performance. Better to do the work now then get to New York, start the race and wish you had.
Arlington, Va.: We are about to have our first child and I am concerned about how little time I will have to exercise (and sleep). If I only have 20 minutes two- to three-days-a-week, what should I do to get the most out my limited time? Thanks.
Howard Schneider: Congrats Arlington, you are in for a great ride. Before talking about your twenty minutes, consider ways to build exercise into your new family: lots of walking and pushing the stroller; a baby seat on your bicycle; a baby backpack that will let you hike the local trails with the young one tacked on for the ride; baby swim classes at the Y or a local gym will get you moving in the water and get your kid used to it at the same time. Point is: yes having children upends your life and leads to lots of new demands on your time. But you can also do stuff together: when you get to the playground, get in a swing yourself.
As to the twenty minutes, I'd look for something that's as total body as you can get: a boot camp, a really aggressive calisthenic program, weightlifting, something that will not just work your legs and heart, but make sure your back and arms and hips and abs get attention too...
Vicky Hallett: Not sure if you're the mom or dad of this bundle of joy, but do you know about Stroller Strides (strollerstrides)? It's a popular workout program for mommies to get together, exercise with their kids (literally -- like lifting them instead of weights) and talk about what they're going through.
Better high heels: Go to a Comfort One store or browse the Web site. All the brands they carry are pretty foot-friendly. Even if you don't end up buying there (they're pricey, unless you find a sale!) you'll know what brands to look for. The most comfortable heels I have are a pair of Beautifeels I got through them.
Vicky Hallett: Yeah, Beautifeels rival Sex in the City shoe prices, but they're another popular brand. Thanks for the tip!
Howard Schneider: I have now bowed out of this discussion....
Washington, D.C.: Hello all! Quick question on an elliptical -- is it better to go at a higher speed with no (or very little) resistance, or at a slightly slower speed with more resistance? I want to stay in shape and am doing this mostly for the cardio. Thanks!!
Howard Schneider:"Better" is always a difficult word in this regard. How about "what's the difference?" Lots to consider. For example, there are different types of muscle fiber -- fast twitch fiber that helps us sprint, and slow-twitch fiber that helps us through endurance events. If you go really fast, you are training the one; slow it down and up the resistance and you are training the other. Both approaches will get your heart rate up (you already know this). To me, the watchword here is diversity: whatever you are inclined to do, if you do ONLY that, you'll pretty quickly derive the benefit and stop making progress. So mix it up -- workout to workout, or even within a session. Do some sprint intervals, then up the resistance and go a bit slower. Above all, keep track of what you are doing, and gradually try to make it a bit harder and a bit faster...
Vicky Hallett: And use the "random" function! I love the random function -- it's an easy way to make sure you're getting a mix during one workout.
New England: This might be a bit of a rant -- sorry. What is your opinion of HIIT cardio vs. steady state cardio? The web forum I am a member of seems to be over-run with a HIIT cult. They are truly fanatical. My base has always been 45-60 min of steady state 65-85 precent max HR regardless of the mode - jogging, bicycling, roller blading, hiking.I do enjoy HIIT on occasion as a change of pace, but never found it to be a sustainable method and certainly not suitable for beginners. Help me, Obi-Won-Kenobi -- your are my only hope.
Howard Schneider: Help you I will, Jedi. The research is showing pretty consistently that Hi Intensity Interval Training -- brief periods of intense activity -- packs many of the same benefits of lower-intensity workouts into a shorter time. It boosts endurance, helps control weight, makes us more efficient, etc. Do you have to do it? Not to my mind. If you enjoy what you are doing and it works for you, that is the prime directive: HIIT can be uncomfortable and unless you are trying to meet a particular goal -- like getting faster -- you should stick what you've been doing. One of the main advantages of HIIT is time-efficiency -- running for say, half an hour, instead of the 60 minutes you are currently putting in. That does not seem to be a concern for you. Now, as a plateau buster, it is something to consider -- if, for example, you wanted to jump your one hour run from 6 to 6.5 mph, then a HIIT or interval program once or twice a week would help you do that. And, yes, it is probably not something beginners should pursue.
Stamford, Conn.: Hi Misfits. Great online chats and info you provide. Do you know any boxing workout dvds that you could recommend that offer great workouts, but also some fundamentals of the "sweet science" as boxing is sometimes called? Thank you.
Vicky Hallett: I have to admit I haven't seen so many pure boxing DVDs. Generally, it's kickboxing. But I tried out an awesome one last weekend -- Gaiam's Kickbox: Core Cross Train. I really felt it the next day. Ow.
Can anyone else help Stamford out?
Arlington, Va.: I need to get a bike tune up, I think. Anywhere in NoVa or Georgetown that is inexpensive and also thorough (and will add a water bottle holder for me)?
Howard Schneider: Tons of them....The Washington Area Bicyclists Association maintains a list of local shops by jurisdiction. Dont know all of their tune up prices but any will do a good jog on your machine. As for the water bottle, that's one I could even do myself (but they'll be happy to do it for you too...).
Minneapolis: In regards to the first-time marathoner, speedwork will also add variety to your training program, because believe me, it will get boring after a while! I personally hate tempo runs (do them anyway), but hills and some 800m's are great variations on 'just another long run.' The workouts will also boost your confidence during rougher parts of the course, including inclines, undoubtedly. Have fun!
Howard Schneider: Yes I'd agree on this one. If you saw the piece I did on half-marathon training a while back, the tempo workouts really help, and I regretted in the end not doing the hills. I guess ultimately the more diversity you build into you program now, the more prepared you'll be and the more fun you'll have.
Washington, D.C.: Good morning. I have a question about gym pricing. I'm about to start looking for a new gym, and I'm already dreading the "we don't print a price sheet" line. It really bothers me how some gyms refuse to publish their rates on their websites. It seems like blatant price discrimination; we'll decide how much to charge you based on what we think we can get out of you in person and how much we want you. Anyway, what to do in this situation if I otherwise would like to join the gym? How best to bargain? Thanks.
Vicky Hallett: As annoying as it is that they don't publish prices online (and believe me, it drives me bonkers), it could work to your advantage, especially right now. Gyms pull in most of their business in January and February, when people are still attempting to fulfill their New Year's resolutions. Although summer will certainly bring in a few people who find it too hot to exercise outdoors, there are tons of fitness opportunities in the warmer months that don't require joining a gym.
What I'm trying to say is that if there were ever a time to bargain, it's now! I have a friend who talked the Bally Total Fitness at Pentagon Row into giving her an absurdly good deal.
I'd get quotes from a couple places, and then ask your favorite one to match the lowest price. Or maybe go a wee bit lower. It couldn't hurt to try, right? Flex that bargain muscle!
Washington, D.C.: The Cole Haan Nike Air's maybe? They are costly, but look pretty fancy.
Vicky Hallett: I just took a peek at the Air selection on Colehaan.com, and good call, D.C. Howard has so many options for his next column on this.
Kickboxing: I have to second Vicky's comment on Gaiam's Core Cross Train workout. It's awesome and I love it! I can really feel it in my abs and legs.
Vicky Hallett: I'm not sure it's "sweet science," but it sure is something.
For Silver Spring Re: Elliptical: Check on Craigslist, there are lots of ellipticals for sale for really great prices. My experience has been that people sell them because they are looking to upgrade or are moving and can't fit them in the new place. And you can call Sears to help you move it and/or put it together!
Vicky Hallett: Second-hand home exercise equipment isn't all that hard to come by. People buy something with the best of intentions and then lose interest. But I'd be wary of anything used you get online -- make sure you can really try it out for an intense workout before you buy. They could be trying to unload it because it makes strange noises or seems broken and then you just spent $1000 on a piece of junk.
But Sears will move it and put it together for you? That's good to know!
Baltimore, Md.: My son, age 25, just joined a gym and plans to work out in the morning because a friend told him "you will raise your metabolism all day." I think this is false, but I don't want to discourage him. How long does the after-burn really last?
Howard Schneider: Good question and it is something I have been intending to try to understand more about. Based on what I know now, I think it is less important when you exercise than how long and how hard -- i.e., harder workouts produce proportionately more "afterburn" than lighter ones, and longer workouts proportionaly more than shorter ones (and the key word here is proportionate, i.e., the benefits arent linear but progressive).
The idea here is that exercise not only burns calories while it is underway, but creates excess oxygen consumption (i.e., calories burned) for several hours afterwards as your body works to recover. There is one school of thought that working out in the morning before breakfast is better for weight loss because your body is in a "fasted state" and needs to rely on its fat stores to fuel the work. BUT: I dont buy it. If your body is depleted you won't work as hard, will tire more easily, etc. The key for your son is not when he gets to the gym, but what he does there and how consistently. The "afterburn" is really the icing on the cake, not the batter.
Sweating a lot: There is a medical condition called hyperhydrosis (excessive sweat production)that can be treated with a prescription strength antiperspirant. His or her doctor can advise them. Hydration is the key, though, as this poster is doing.
Howard Schneider: I think this mostly has to do with sweating in the absence of exercise -- i.e., without an obvious reason for the sweating to occur. But good to know about nonetheless.
Brookland -- Washington, D.C.: Hello MisFits! I'm a 33-year-old male, 5'10" 160 lbs and currently go the gym about 5 times a week -- 3 days with about 40 min on the elliptical, other 2 days with intermediate/advanced yoga. I've never been fond of going to the gym but have found that I actually like yoga and don't mind doing the cardio (I can mentally check out and listen to music). I've actually been able to stick to this routine since the beginning of the year (thanks in part to home renovations that rendered my shower inoperable for a while). My question to you is this: Am I missing out by not mixing up the routine more or doing weight training? My weight has held steady over the months but I can tell I'm trimmer by the way my clothing fits. I have a couple "problem areas" but nothing that I get too bothered by. Would it be advisable to add some weight training into the mix or is the fear that I'd hate it and quit altogether enough to just keep on trucking with what I'm doing?
Thanks for your advice!
Vicky Hallett: Tough call Brookland -- if you have a plan that's working for you, I hate to rock the boat. But are you missing out by not mixing up the routine more and doing weight training? Probably yes and yes.
It's great that you've found things you like doing, and an advanced yoga practice is almost certainly giving you resistance training benefits. But the body gets bored, and while these things are somewhat new to you now, they're not going to be as effective if they're all you do down the road.
Do you really think sampling a new element that you end up disliking is going to make you give up on all exercise? That's a lot of pressure, but I'm guessing it's not true. Try something new! And if you don't like it, try something else. We're always here to give you ideas if you run out.
To Washington, D.C.: Regarding gym memberships -- read the fine print. Some are incredibly difficult to LEAVE once you've joined. I had a horrible time with Bally's even after I had been a member for the three years I was required by contract. Not sure if they've changed policies. At any rate, when shopping around, make sure you ask if there are any penalties, extra fees or any other hoops to jump through if you decide to cancel your membership.
Howard Schneider: Good advice. I think a lot of profit from the gym chains comes from unused memberships -- that is gravy for them, since it is money in the bank without the requirement of staff or equipment or overhead. Now, they make more money in the long run if you use your membership and dont quit, but, still, read the contract.
Stepping it up: Not seeing the results I want to with my regular exercise program (losing weight and more muscle definition). I regularly walk 2-3 times per week, aerobics twice a week, toning once a week, yoga once a week. I think my problem may be the layer of fat covering the muscle since I need to drop 20 pounds. I figure I should step it up and start lifting weights for 45 minuntes at lunch. I currently use 5 lb. and 8 lb weights in my classes, aerobics and toning class. Do I need to purchase heavier weights? The 8 lb. weights are still a struggle on certain moves but easy on a few. Should I use these lunch time sessions to tone or use heavier weights to build muscle? Thanks!
Howard Schneider: Lots to sort out there...
First lets talk about weight loss and the aerobic portion of your program. If you are walking each week and doing aerobics each week, that sounds like plenty -- but for how long and at what intensity? Weight loss occurs when you burn more calories over time than you consume. If those workouts are light to moderate, for half an hour or so, that will meet the general recommendations for health, but might not be intense enough to help you shed the pounds you want. You need to look at what you are doing in the context of what you eat each day, and figure out if you can up the intensity of your exercise (maybe light job instead of walking), and ensure that you are eating a balanced diet of health foods.
Richmond, Va.: I swear by good shoes with molded foot beds. I wear Merrills to work as much as possible and wear Keens on casual Friday. I know the conservative folks at work think I'm a hippie freak, but my feet and back thank me. Yeah for Merril for making work-friendly shoes that love my soles!
Howard Schneider: Sitting here in my very own hippie-freak Merrills, I can't agree more...I hate shoes. I hate thinking about shoes. I have the idea of shoes. Worse than haircuts. These make it easy.
Falls Church, Va.: In regards to shoes, I just wanted to put out there how much I LOVE my Earth shoes. They are fantastic and I have noticed how much more toned my legs are since wearing them.
Howard Schneider: And do you drive an American Motors Corp. product?
Penn Ave Misfit: I have a problem most people would love to have. I'm a 30-something-year-old woman who was recently told by my doctor that I needed to gain some weight because I plan on trying to have a child soon. She sent me to a nutritionist who put me on a high-calorie diet, but I know I also need to start working out in order to keep this up. I've always had a normal, healthy appetite, but the skinny gene is prevalent in my family. Now eating isn't just for function or pleasure; I have a goal in mind. This is all new to me!
What kinds of exercises should I be doing so I'll feel compelled to eat more? I'll admit my 5 block walk to and from the metro is the most exercise I get a day. But I obviously don't want to burn too many calories either.
I feel like a true misfit!
Howard Schneider: Yea this one is alien to me, and I'd love to hear from the audience. But in general if you are trying to gain weight, you'll probably want to focus on strength training activities that will prompt your body to build muscle. Walking, running and other cardio exercises will certainly make you hungry but will burn calories without, generally, any added "growth." Weight training will let you add some healthy pounds. Did the nutritionist have no advice on this?
Alexandria, Va.: Hi MisFits. I'm curious what you think about hydration systems. I am training for the Marine Corps Marathon in October (my first) and am to the distance now where I need to bring fluid with me. I really hate wearing a fuel belt; all the sloshing and jiggling and movement of the belt is really distracting. Have you tried one that is really good? What about a camelback system? Thanks for your thoughts!
Howard Schneider: I have not run with a Camelback but own a couple for biking and hiking...Three things to consider:
1)Have you tried the handheld bottles? These are not my cup of tea but they will get the weight off your hips (these are water bottles in holders that fit around your palms. Any running store will have them).
2)I ultimately went with a single bottle in a very secure holder, as opposed to all the little bottles....Have you checked those out?
3)Keep in mind there will be hydration on the course, so you just need to figure this out for your training. Could you stash some bottles around the routes of your long run?
Washington, D.C.: Was out jogging the other day and started feeling stiffness in the muscles in the front of my shin (not the calf muscles, I guess, but half-way down my shin). I tried stretching it out, but I couldn't find a stretch that wasn't awkward and futile. I'm a little confused because that stiffness had never happened before, and it didn't hurt, though I could tell it would if I had kept jogging. Any suggestions for what kind of stretches I could have done/could do in the future?
Howard Schneider: Running out of time, but here is a bit on shins from a racewalking Web site. Hope it helps.
For the boxer: I have a heavy bag and got 2 DVD's by Everlast that teach you the fundamental boxing moves. Look for them on Amazon. Also, I do Tae Bo DVDs, and hit the heavy bag in time with the movements. Super workout and a way to let out aggression! Hope these help the potential boxer out.
Howard Schneider: Great advice
Alexandria Biking: I am considering buying a bike -- people rave about the trails here and I know biking is good exercise. The thing is, I don't want to spend a fortune on my first bike out the gate in case I hate riding and never want to do it again. Can you suggest a good inexpensive "starter" bike and the equipment that I should have, too?
Vicky Hallett: If there's a chance you're going to hate riding and never do it again, I say rent before you buy (there's a list of some places to do that at Bikewashington.org/rentals, although I'm not sure how up to date it is).
Another option if you're looking for a deal is to try Phoenix Bikes in Arlington (phoenixbikes.org). Their bikes are all donated and then fixed up by local kids, so you'll feel good about it even if you never ride.
Howard Schneider: Other question is what do you consider a fortune? You can find a decent bike for three hundred bucks or so and get the advangate of ensuring it fits properly by going to one of our many good local bike shops. Part of whether you enjoy the sport will depend on getting equipment that fits your body -- if you wake up with a sore back and knees you WON'T like it, and that's one of the things that can happen with a bike that is the wrong build. Used bikes are an option, as Vicky said. As to equipment: a helmet, a saddlebag with a spare tube and/or patch kit, an onboard pump to get you home in case of a flat, a water bottle cage, tire repair/multi tool to fix common problems....NO IPODS!!!
Chinatown, D.C.: Lately when I've been running on the treadmill, my joints seem to alternate in pain (left ankle one day, right ankle the next). Anything I can do to correct this?
Vicky Hallett: Wherever it's coming from, pain is always a red flag, Chinatown. It could be the sign of overuse, so I'd see if easing back on the speed/distance/frequency reduces your problems. You might also want to have someone take a look at your gait to see if you're doing anything that might be exacerbating the problem. A treadmill surface, unlike a road, should be even, so you can't blame it on a curve in the pavement.
Washington, D.C.: So I have some advice to ask. Thanks in part to you two, I started walking about 4 months ago. When I lost a little weight and got more fit, I started running/walking. I exercise everyday now, but do the "hardcore" run/walking for about 45 minutes every other day, because I'm training for a 5K.
Most of the time, I go out and exercise and everything is great. However, the last time I exercised, someone passed by in a car, hung his head out of the window, and screamed "Go fatty!" at me, while pointing. (For illustrative purposes, I'm a size 18 woman.) I realize that I'm fat and I'm not making excuses for it, but I'm doing something about my fitness level, regardless of whether it changes my fatness level. The comment completely derailed my workout. I wish I could say it didn't, but it did.
Aside from just not understanding why people are SO STUPID, I need to know how to get past this. I'm nervous about running outside now because of getting another comment. I need to forget it and I can't. Please help.
Vicky Hallett: What a @%$#%$#%$#! That would make me want to toss out my running shoes too. But you can't! You can a 5K coming up!! (And besides, your health trumps all stupid comments made by idiots in passing cars.)
If you're having a lot of trouble motivating on your own, I'd see if you can join up with a group for your runs. Maybe the fun run that leaves from Fleet Feet in Adams Morgan? They'll all be totally supportive. And beat up anyone who messes with you.
He was probably just jealous.
We're so proud of you!! Don't let this derail you!!
Vicky Hallett: Okay, that's it for us today. I think Howard has already left the building. Probably in a pair of really comfortable shoes...See you next week!
Editor's Note: washingtonpost.com moderators retain editorial control over Discussions and choose the most relevant questions for guests and hosts; guests and hosts can decline to answer questions. washingtonpost.com is not responsible for any content posted by third parties.


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The Oita HeatDevils have upgraded Tadaharu Ogawa's job title. He is no longer the assistant coach; he's now the team's new head coach, the bj-league team has announced.
Ogawa played for the team during its first two seasons in the bj-league and also served as an assistant to Dai Oketani, who was fired after his team's 19-25 season in 2007-08. The Ryukyu Golden Kings have hired Oketani as head coach for the upcoming season.
Ogawa, who turns 39 in December, also suited up for the Niigata Albirex BB during his playing days as a forward.
The HeatDevils gave Ogawa a one-year contract, which is standard for the league's coaches and players.


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Under the local law, passed this week and due to come into effect from May 1, citizens from other countries both EU and non will have to pay 267 to register with municipal authorities instead of 17 fee charged to Belgians.
Bart De Wever, Antwerp's mayor, whose party, the New Flemish Alliance, advocates splitting Belgium into two states, justified the measure by saying it costs more money to process paperwork for foreigners.
Other supporters of the move however say it is designed to keep out migrants from north Africa. (continue reading...)(...more)


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Orioles' TV Ratings Up
By Dave Hughes, DCRTV.com
The Orioles' TV ratings are up so far this season. For the first 26 games of the 2011 season, the Orioles saw a 24 percent rise, compared with the same period last year on the Mid-Atlantic Sports Network -- with a 33 percent year-to-year elevation in men age 18-34, and 25 percent higher numbers among men age 25-54, according to the Baltimore Sun.
The Birds are also seeing a rise in their Washington, D.C., audience, which is more than twice as large as it was last year. The Orioles nabbed a 1.5 household rating or a 35,000-household game average in the Washington market through 26 games.
"The Orioles have a proven, loyal and knowledgeable fan base -- even in down years, we've been able to generate solid ratings," John McGuinness, MASN senior vice president, told the Sun.
The Nationals are also seeing a TV ratings elevation, with the team's numbers up 78 percent compared with last year, from a 0.9 to a 1.5 rating via MASN in the Washington market.
* * *
Orioles games on WBAL, AM 1090, are getting about the same ratings as sports talker WJZ-FM, 105.7 The Fan's evening sports talk, which is mainly football and the Ravens. That's according to Dave Labrozzi, who is VP of programming for CBS Radio Baltimore, which owns WJZ.
In the overall local radio numbers, of all listeners age 12 and older for the month, 105.7 was ranked 17th place for the month of April.
But representatives from the CBS station said it's doing quite well among male listeners, especially in its key demographic, even without Orioles play-by-play (the Orioles moved from WJZ to their old, longtime haunt of WBAL after last season).
Now, Labrozzi said in the demographic of men aged 25-54, WJZ and WBAL were tied for fourth place in evenings during April, according to the latest batch of Arbitron numbers.
Also, the April numbers show that WJZ's unofficial pre-game show, "Baltimore Baseball Tonight," landed in second place with men 25-54, compared with seventh place for WBAL's sports programming.
And, the Orioles' unofficial postgame show on the Orioles-less WJZ "crushed" WBAL, Labrozzi said. From 10 p.m. to 11 p.m., WJZ was tied for first place with men 25-54, while WBAL was tied for 23rd place.
* * *
ESPN 980, WTEM, jumped the gun and reported that Sean Miller would be named new basketball coach at the University of Maryland -- but the scoop turned out to be inaccurate.
Chuck Sapienza, the sports talker's top manager, posted an apology on the station's Facebook page: "Breaking news, while always a difficult animal to tame in the era of social media, is still as simple as getting the story 100 percent correct. You have my word we will improve our fact checking and sourcing. While mistakes do happen in our business, this will not be tolerated or taken lightly. I appreciate all of our listeners and take our credibility very seriously."
Posted May 20, 2011


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PRZOOM - /newswire/ -
Frankfurt, Germany, 2011/10/24 - Dr. Robert Blackburn (43) will become President of BASFs Information Services competence center, located in Ludwigshafen, Germany, effective January 1, 2012. Blackburn is currently Senior Vice President, Global Supply Chain & Process Innovation. DE000BASF111
Andrew Pike (55), currently President of Information Services, has elected to leave the company effective December 31, 2011. He will return to his home country Australia.
About BASF
BASF (basf.com) is the worlds leading chemical company: The Chemical Company. Its portfolio ranges from chemicals, plastics, performance products and agricultural products to oil and gas. As a reliable partner BASF creates chemistry to help its customers in virtually all industries to be more successful. With its high-value products and intelligent solutions, BASF plays an important role in finding answers to global challenges such as climate protection, energy efficiency, nutrition and mobility. BASF posted sales of about 63.9 billion in 2010 and had approximately 109,000 employees as of the end of the year. BASF shares are traded on the stock exchanges in Frankfurt (BAS), London (BFA) and Zurich (AN).
Agency / Source: BASF
Availability: All Regions (Including Int'l)
Traffic Booster: [/] Quick PRZOOM - Press & Newswire Visibility Checker
Distribution / Indexing: [+] / [Company listed above is a registered member of our network. Content made possible by PRZOOM / PRTODAY indexing services]


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It only takes a minute to get started. Fill out our uncomplicated sign up form and login to the site.
This step is optional but will seriously increase your chances of getting interest from other Christian members on the site. Type a little about yourself, your interests and upload any nice photos of yourself.
Utilise our website's sophisticated search to pinpoint members who satisfy your requirements. Or just flip through listings of Christian singles and pinpoint folks that you like.
Found someone who tickles your fancy? Send a letter to them or just a wink and find out if they're interested in you. With a little luck you'll be on your way to uncover the love of your life.
It's quick and simple


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Tuesday, September 19, 2017
Lung diseases
Fiberglass Exposure
I removed a fiberglass tub from my bathroom with a sawzall with limited respiratory protection. There was a lot of dust generated and I was wondering if I should be concerned. I was in the bathroom for ~ 2 hours while working on it.
Thanks for your help!
I don't see too much to worry about here - the levels of exposure workers get is way beyond what you might have gotten in this limited exposure. Health effects of fiberglass exposures have not been very obvious, even among highly-exposed workers.
J Mac Crawford, PhD, RN
Clinical Associate Professor of Environmental Health Sciences
College of Public Health
The Ohio State University


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Turkish journalists from the local Cumhuriyet newspaper are facing multiple life sentences for publishing a story and a video revealing that Turkish intelligence were carrying weapons to anti-government forces in Syria.
Dogan news agency reported that prosecutors asked an Istanbul court to sentence the newspaper Cumhuriyet's editor-in-chief, Can Dundar, and Ankara bureau chief, Erdem Gül, each to a penalty of one aggravated life sentence, one ordinary life sentence and 30 years in jail.
Turkey must allow supporters to meet with imprisoned journalists Can Dündar and Erdem Gül https://t.co/Mp4EUIxzwI @RT_Erdogan
— CPJ Eurasia desk (@CPJ_Eurasia) January 27, 201
The two well-known journalists are facing charges of "gathering secret state documents for the purposes of political and military espionage," "attempting to topple the government of the Republic of Turkey or attempting to stop either partially or totally the government from fulfilling its duties" as well as the "deliberate support for a terrorist organization without being a member."
RELATED: Thousands Gather to Protest the Arrest of Turkish Journalists
The men were arrested in November last year over a video they published showing trucks owned by the Turkish National Intelligence Agency (MIT) in southern Turkey in early 2014.
For good journalism you can get 30 (!) years of prison in #Turkey: "The case Can #Dündar and Erdem #Gül" pic.twitter.com/qSl4edyYSo
— MineParis81 (@MineParis81) January 27, 201
The paper claimed the video was proof the trucks were carrying weapons shipments to extremist groups in Syria fighting against Syrian President Bashar Assad. The trucks were let go a short while after when the police searching them received a call confirming the drivers were MIT agents.
Turkish President Recep Tayyip Erdogan and Hakan Fidan, the head of the MIT, are named as plaintiffs in the 473-page indictment, Dogan agency reports. Fidan is one of Erdogan's most-trusted allies within the government.
RELATED: Syrian Army: Turkey Increasing Arms Shipments to 'Terrorists'
Dundar and Gul have been in the maximum security prison Silivri since November. Erdogan, founder of the Justice and Development Party (AKP) which has a parliamentary majority, personally filed the lawsuit back in June and said the people behind the story would "pay a heavy price."
Shocked by life sentences demanded against #Cumhuriyet journalists C.Dündar+E. Gül. Equality + proportionality before the law are a must 1/3
— Johannes Hahn (@JHahnEU) January 27, 201
Turkish Deputy Prime Minister Numan Kurtulmus said Wednesday that his government opposes the pre-trial detention of the pair but it was up to the judiciary to decide on the matter of their detention.
RELATED: Chomsky: US Ally Erdogan a 'Murderer' Viciously Killing Kurds
However, many in Turkey argue the judiciary has been acting in favor of the government on most occasions especially against journalists. In fact, AKP-led government made changes last year to laws giving the government more powers over Turkey's High Council of Judges and Prosecutors.
ANALYSIS: G-20 Summit in Turkey: Erdogan Hopes to Fix Image amid Crisis
The justice minister is the chairman of the seven-member council. Also, the president of Turkey has the power to appoint four of the seven members of the council, which appoints all judges and prosecutors in the country.
WATCH: The World Today: State Terror in Turkey


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Credits acknowledge special thanks to Jennifer Heddle, Leland Chee, Troy Alders, Carol Roeder, Jann Moorhead and David Anderman at Lucas Licensing.
Recap of story to date, creator credits and indicia.
The events in this story take place approximately 139 years after the events of Star Wars: Episode IV - A New Hope.
Cover preview of Star Wars: Legacy #13.
Preview of covers from Star Wars titles being released in February 2014.


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new book – 'The Addicted Brain: Why We Abuse Drugs, Alcohol, and Nicotine'
Written on November 30, 2011
The Addicted Brain: Why We Abuse Drugs, Alcohol, and Nicotine (FT Press Science) by Michael Kuhar (FT Press, 2011)
Product description from the publisher:
What Science Has Learned About Addiction:
What causes it?
How do drugs change the brain?
Who's most vulnerable?
Does treatment work?
What can we do?
Addiction destroys lives. In The Addicted Brain, a leading neuroscientist explains how and why this happens–and presents advances in treatment and prevention. Using breathtaking brain imagery and other research, Michael Kuhar, Ph.D., shows the powerful, long-term brain changes that drugs can cause, revealing why it can be so difficult for addicts to escape their grip.
In plain English, Kuhar describes why some people are far more susceptible to addiction than others. He illuminates striking neural similarities between drugs and other pleasures potentially capable of causing abuse or addiction–including alcohol, gambling, sex, caffeine, and even Internet overuse. Finally, he outlines the 12 characteristics most often associated with successful treatment.
Authoritative and easy to understand, The Addicted Brain offers today's most up-to-date scientific explanation of addiction–and what addicts, their families, and society can do about it.
See also: Author's homepage
Google Books preview:
Filed in: cognitive science,new books,psychology.


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News Release
Media Contact: TPWD News, firstname.lastname@example.com, 512-389-8030
Nov. 12, 2013
TPWD Shocks Up Big Bass at Lake Ray Hubbard
Recent electrofishing surveys conducted by Texas Parks and Wildlife Department (TPWD) Inland Fisheries biologists turned up a surprising number of big largemouth bass in Lake Ray Hubbard.
TPWD's Inland Fisheries district office in Fort Worth is responsible for managing and monitoring Lake Ray Hubbard's fishery. Each fall they conduct a nighttime electrofishing survey on Lake Ray Hubbard. Electrofishing, commonly known as "shocking," uses electricity to temporarily stun fish, which are then collected using dipnets, measured and weighed.
The two-night survey consisted of 24 randomly selected stations around the shoreline of the lake. Each area was electrofished for five minutes and all target species, which included shad, sunfish and black bass, were collected.
Despite low water levels, this year's survey revealed record catch rates for largemouth bass over 14 inches. Incredibly, the best five fish weighed 34.62 lbs. That is not bad for a lake within easy driving distance for many DFW area anglers.
Most big fish were collected along the many areas of riprap found around the lake. The two biggest fish were each 23 inches long and weighed 8.1 and 7.2 pounds.
Ray Hubbard continues to be a great spot for sportfishing and has produced two Toyota ShareLunkers, fish weighing 13 pounds or more. The most recent ShareLunker entry was in 2003.
Because of its big fish history and good habitat, Ray Hubbard has been stocked annually with Florida largemouth bass since 2010. This year TPWD added another 502,264 fingerlings with expectations that the Florida influence will produce even more big fish.
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(5.4.16 i)