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Erin Sadlier was absolutely fantastic. So knowledgeable, diligent and efficient. She made our loan process a breeze!
Kimberly M. -Bedford,MA | SEP 2016
Thanks Erin! Was so easy and stress-free. Appreciate that you reached out to help me save money and time!
David H. - 6/9/2016
Erin Sadlier at Guaranteed Rate has helped us a few times now. First time home buying and refinancing we've been repeat customers because of the great customer service and quick turn around time!
Ennio A. - Framingham, MA | APR 2016
This is our second time using Guaranteed Rate. Erin was very great about explaining things to me and answering all of my questions. Both Jennifer and Chelsea were quick to respond and made sure all of the paperwork was in order. Cheryl was easy to work with and knew her stuff.
Renee B. - Pepperell, MA | Jan. 2016
Erin was phenomenal! I would recommend her to anyone!
Christina T. -- Arlington, MA 7/24/2014
Joan and I want to thank you for all of your help, support and guidance throughout our loan process! Selling and purchasing a home is overwhelmingly stressful, so we really appreciate your efforts in making our loan application and approval process flawless. We had a few high anxiety moments with both our buyer and seller, but we're finally settling into our new home and we're very happy. We will highly recommend Guaranteed Rate to all of our friends and family!
Dave and Joan
It was a pleasure to work with Erin and her team for the second time. They worked efficiently and stayed on top of our account throughout the whole process, from the preapproval to the closing. Erin was able to answer all our questions and ease our concerns. She absolutely went above and beyond the normal service you would expect. I would (and do) recommend Erin to everyone I know for their financing needs. I am sure I will work with her again in the future.
Brian F. - Newton, MA - 7/2013
"Working with Erin Sadlier was one of the highlights of closing on my home in June. She was always available and open to questions, extremely knowledgeable and helped to prepare me so that there were not any "surprises" along the way. The whole process was seamless...I walked away feeling like I locked into a good rate and I had someone solid working with me. We closed on the exact date we planned without any issues. Erin is someone I would gladly recommend to family and friends who are looking...
Tatum O. -- Haverhill, MA -- 7/2013
Hey, check out this amazing review from Matthew about Erin! "I had a great experience during my purchase. Everyone who worked with me during the loan process went above and beyond to ensure the loan went smoothly. I also want to especially thank Erin Sadlier and Hilary Clark for their help. I could not have completed the loan without them!"
Matthew R. -- Ashland, MA – 4/2013
Superb. It was fast and painless for me. Erin managed to stay on top of things and got everything done the first time around. After that it was just waiting for closing.
Ralphe M. Boston, MA 3/2012
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Grand Bazaar, Isfahan
From Wikipedia, the free encyclopedia
(Redirected from Grand Bazaar, Esfahan)
The Grand Bazaar (in Persian: Bazar Bozorg, بازار بزرگ) is a historical market located in Isfahan, Iran, also known as "Qeysarriyeh Bazaar" (in Persian: بازار قيصريه).
It was originally constructed during the 11th century, on the southwest wing of Jameh Mosque and Kohneh Square but various arcades and rooms were later added to it. The present remnant dates from the Safavid period, during which the Qaysariya Bazaar was built on the north wing of Naqsh-e Jahan Square, a square which was developed as a substitute for Kohneh Square.
- Dehbashi, Ali (2003), Isfahan, Tehran: Gooya House of Culture & Art, ISBN 964-7610-01-7
Coordinates: 32°39′38″N 51°40′35″E / 32.6606°N 51.6763°E
|This Iran-related article is a stub. You can help Wikipedia by expanding it.

subset: commoncrawl


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If you are looking for travel information of Grampians in Australia, you've come to the right place. The nearest major city to Grampians is Daylesford. So, ideally any vacation planner would recommend you to visit Daylesford for its bountiful attractions like Lake Daylesford, Renewal Massage, Shakti Massage on your trip to Grampians. Also, to reach Grampians, you'll have to take a flight to Daylesford; so its not really a detour. And even if it is, the city is worth paying at least a quick visit. Most online packages to this city are of 1-2 days.
Get, set and plan a journey with this amazing travel planner for Grampians that shall leave you with plenty of memories at the end of your trip.
Explore the best journey planner for your visit to Grampians and create a flawless plan in few simple steps!
You may also be in interested in other popular destinations in Australia like Sydney, Melbourne, Adelaide
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You or your landscape service mows your lawn with an electric, propane or reel mower rather than a standard gas-powered mower. We recognize this may not be an option for every homeowner; the type of mower used will depend on your lawn and – if you use a service – the company's equipment.
On my own
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If you hire out your lawn care, it doesn't hurt to ask about the equipment being used and to share your interest in such eco-friendly advances as propane- and electric-powered mowers. Propane mowers, in particular, are becoming more popular within the lawn care industry. Though changes might not happen overnight, companies do listen to their customers and take their input into consideration when replacing equipment and investing in new training. While talking to your lawn care company, please consider our other tips as well.


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Now the story of the Enfield Poltergeist is to be made into a film and its producer hopes it will be a Hollywood hit.
The Hodgson family were frightened out of their wits by the incidents that began in 1977 with a series of ghostly bumps in the night but appeared to develop into furniture, toys and crockery being flung around.
One photograph taken at the time appears to catch 11-year-old Janet Hodgson suspended in mid-air after flying out of bed. She also began to speak in an elderly man's rasping voice.
Paranormal investigators claimed she had been possessed by a spirit belonging to Bill Wilkins, who had lived in the house some years before the Hodgsons but died of a brain haemorrhage.
It lasted just over a year, stopping in September 1978 with a small recurrence reported again in August 1980.
Shooting on events inside the house in Green Street will begin in the new year. Deadhouse Productions has already trademarked the name The Enfield Poltergeist, created a trailer and is in talks with distributors including Lionsgate films, which was behind the Saw horror franchise.
Today one of the film's producers told of his excitement at revealing "the untold story." John Kyriacou added: "I used to go to the same school as the family so it's a story that I've grown up with. It's the most documented evidence of poltergeist activity in the world. Opinions remain divided. There are a lot of sceptics out there and this will be the perfect film for them."
One family who is not sceptical is the Bennetts. Clare Bennett was not aware of the house's haunted past when she moved into the property in 2004 but only stayed there for two months. The mother of four said: "I didn't see anything as such but I just felt uncomfortable. I wasn't settled there. I'd unpacked all our stuff but it still didn't feel right. There was definitely some kind of presence in the house, I always felt like someone was looking at me."
"I couldn't explain what it was because we had no idea the house was haunted so I asked my sister to look into it and suddenly it all made sense."
Her son Shaka, now 15, was most disturbed by the house. He said: "I'd wake up at 3am every morning and I'd feel scared because I'd hear people talking downstairs.
"The night before we moved out, I woke up at the usual time and I saw a man into the room. I ran into my mum's room and said, 'we've got to move,' and we did the next day.
Janet Hodgson broke her silence for a TV documentary four years ago in which she said: "I felt used by a force that nobody understands. I really don't like to think about it too much."
Hazel Short, 65, a former lollipop lady who worked outside the house, said she remembered seeing Janet hovering horizontally by a window. "I will never forget what I saw and felt in that house," she said.
Today, a woman who now lives in the house said: "Do not mention what happened in this house. I've got young children inside, they don't know about it and I don't want to scare them."
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The Indian Cricket Team's limited over skipper Mahendra Singh Dhoni turns 35 on Thursday.
Born in Ranchi, in July 1981, Dhoni in his school days time was good at badminton and football, but his football coach, impressed by his goalkeeping skills, sent him to play cricket.
And, then he changed the fortunes of the Indian cricket.
Let us look at M S Dhoni's journey, his milestones and his love life which a lot of people are not aware of.
- How MS Dhoni Switched From Football To Cricket?
He was goalkeeper of his football team
His coach insisted him to play cricket
He was selected for Bihar Ranji Trophy squad in 1999
In 2003, he was selected to the India A team
Made his ODI debut in 2004
- M S Dhoni's Milestones
His two spectacular knocks for Team India -148 vs Pakistan in Vizag in 2005 and 183 vs Sri Lanka in Jaipur again in 2005 made him the star. And, after that he never looked behind.
He led India to Inaugural ICC World T20 victory
He was then made permanent ODI Captain of Indian team
In 2008, he became the captain of the Test team too
In 2009, he became highest scorer of the year in ODI's
He won the 2011 ICC Cricket World Cup
Only captain to have taken home both ICC world cups
Dhoni's 224 is highest score in a Test by a Indian capt...
Dhoni is most successful Indian Test Captain, having wo...
- Dhoni's Love Life
Dhoni & Sakshi, have Bollywood-inspired love story
They did not fall in love in their childhood
Both Dhoni & Sakshi went to same school in Ranchi
Sakshi's family got shifted to Dehradun
Dhoni & Sakshi incidentally met each other at Taj B...
Sakshi was introduced to Dhoni by his manager
The couple got married on July 4, 2010
The couple became proud parents in February 2015
For all the latest news and updates from India and across the globe, follow us on @NewsWorldIN on Twitter and News World India on Facebook


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The limo service that we got for a birthday was so worth it! We were really floored with the limos and it was like having your own party in there with the neon lights and all. We only had the limo for two hours but the driver was keenly aware of that fact and made sure we got o..
good friendly people cheap prices I had problems with mechanics not being able to diagnose my car I got in without appointment they were great
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Belk & Co. Opal and Crystal Stud Earrings in 14K Yellow Gold
$105.00 Original Price $150.00
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These 14k yellow gold earrings feature 2 freshwater pearls and crystals that measure 8.38-mm. length x 8.38-mm. width.
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Author: Terry Wilder
A Prayer for Partners in the Advance of the Gospel
"I want you for U.S. Army." "We do more before 9AM than most people do all day." "Be all that you can be." Most of us will recognize these statements as maxims used in the past by the U.S. Army. One of the Army's more recent slogans was, "An ar... Read More »
Why Do Christians Suffer for Their Faith?
Early Christians suffered for their faith in Christ. Some were incarcerated. Some were beaten and whipped. Some were stoned. Others were crucified or beheaded. Still others later were fed to the lions. Suffering, however, is not limited to New Testament times.... Read More »
The Importance of Biblical Languages
In his Grammar, A.T. Robertson, the noted Southern Baptist Greek scholar of yesteryear, shared the conviction of A.M. Fairbairn when he said, "No man can be a theologian who is not a philologian. He who is no grammarian is no divine."[1] In other words, bo... Read More »
Is It OK for Followers of Jesus to Do That?
How do followers of Jesus Christ determine whether it is right or wrong to do a specific thing? For example, is it OK for Christians to go to the movies? Play poker? Smoke tobacco? Drink alcohol, even moderately? Engage in civil disobedience? How do we answer ... Read More »
Do You Hear What I Hear?
Christmas is a time for singing. What better thing to sing about, especially at this time of year, than the birth of Jesus the promised Messiah? Of the two Gospels that tell of Christ's birth and infancy, it is Luke's Gospel which contains several songs or... Read More »


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horning press
horn press
Definition of horning press
: a punch press with a horn by means of which the seams on hollow tinware are closed
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Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death
© Jeong et al; licensee BioMed Central Ltd. 2011
Received: 6 January 2011
Accepted: 19 April 2011
Published: 19 April 2011
Silibinin, a natural polyphenolic flavonoid, has been reported to induce cell death in various cancer cell types. However, the molecular mechanism is not clearly defined. Our previous study showed that silibinin induces glioma cell death and its effect was effectively prevented by calpain inhibitor. The present study was therefore undertaken to examine the role of calpain in the silibinin-induced glioma cell death.
U87MG cells were grown on well tissue culture plates and cell viability was measured by MTT assay. ROS generation and △ψm were estimated using the fluorescence dyes. PKC activation and Bax expression were measured by Western blot analysis. AIF nuclear translocation was determined by Western blot and immunocytochemistry.
Silibinin induced activation of calpain, which was blocked by EGTA and the calpain inhibitor Z-Leu-Leu-CHO. Silibinin caused ROS generation and its effect was inhibited by calpain inhibitor, the general PKC inhibitor GF 109203X, the specific PKCδ inhibitor rottlerin, and catalase. Silibinin-induce cell death was blocked by calpain inhibitor and PKC inhibitors. Silibinin-induced PKCδ activation and disruption of △ψm were prevented by the calpain inhibitor. Silibinin induced AIF nuclear translocation and its effect was prevented by calpain inhibitor. Transfection of vector expressing microRNA of AIF prevented the silibinin-induced cell death.
Silibinin induces apoptotic cell death through a calpain-dependent mechanism involving PKC, ROS, and AIF nuclear translocation in U87MG human glioma cells.
Glioblastoma is the most lethal and frequent primary brain tumors [1]. It is comprised of poorly differentiated heterogeneous neoplastic astrocytes with aggressive proliferation and highly invasive properties. After diagnosis of glioblastoma, the median survival time of 9-12 months has remained unchanged despite aggressive treatment including surgery, radiation, and chemotherapy [2, 3]. Thus, new effective strategies for controlling glioblastoma are required. Because glioblastoma cells avoid differentiation and apoptosis, the induction of differentiation and apoptosis in glioblastoma cells may be considered as a potential treatment strategy.
Silibinin, a natural polyphenolic flavonoid, is a major bioactive component of silymarin which is isolated from the plant milk thistle (Silybum marianum), and has been extensively used for its hepatoprotective effects in Asia and Europe. It has been reported that silibinin has anticancer activities in various cancers including prostate cancer in both in vitro and in vivo models [4–7]. Recently, we observed that silibinin induces apoptosis through Ca2+/ROS-dependent mechanism in human glioma cells [8]. The study showed that silibinin-induced cell death was prevented by calpain inhibitor, suggesting involvement of calpain activation in apoptosis induced by silibinin. Therefore, the present study was undertaken to examine role of calpain in the sililbinin-induced glioma cell death. The present study demonstrated that silibinin induces human glioma cell death via a calpain-dependent AIF nuclear translocation involving ROS and PKC.
Materials and methods
Silibinin, GF 109203X, rottlerin, catalase, MTT, propidium iodide was purchased from Sigma-Aldrich Chemical (St. Louis, MO, USA). Z-Leu-Leu-CHO was purchased from BIOMOL International LP (Plymouth Meeting, PA, USA). DCFH-DA and DiOC6(3) were obtained from Molecular Probes (Eugene, OR, USA). Antibodies were obtained from Cell Signaling Technology Inc. (Beverly, MA, USA). All other chemicals were of the highest commercial grade available.
Cell culture
U87MG cells were obtained from the American Type Culture Collection (Rockville, MD, USA) and maintained by serial passages in 75-cm2 culture flasks (Costar, Cambridge, MA, USA). The cells were grown in Dulbecco's modified Eagle's medium (DMEM, Gibco BRL, Invitrogen, Carsbad, CA, USA) containing 10% heat inactivated fetal bovine serum (HyClone, Logan, UT, USA) at 37°C in humidified 95% air/5% CO2 incubator. When the cultures reached confluence, subculture was prepared using a 0.02% EDTA-0.05% trypsin solution. The cells were grown on well tissue culture plates and used 1-2 days after plating when a confluent monolayer culture was achieved. Unless otherwise stated, cells were treated with silibinin in serum-free medium. Test reagents were added to the medium 30 min before silibinin exposure.
Measurement of cell viability
Cell viability was evaluated using a MTT assay [9]. Culture medium containing 0.5 mg/ml of MTT was added to each well. The cells were incubated for 2 h at 37°C, the supernatant was removed and the formed formazan crystals in viable cells were solubilized with 0.11 ml of dimethyl sulfoxide. A 0.1 ml aliquot of each sample was then translated to 96-well plates and the absorbance of each well was measured at 550 nm with ELISA Reader (FLUOstar OPTIMA, BMG LABTECH, Offenburg, Germany). Data were expressed as a percentage of control measured in the absence of silibinin.
Measurement of calpain activity
Calpain activity was measured by calpain assay kit (BioVision Research Products, CA, USA) according to the manufacturer's instructions. Cells were grown in 6-well plates and were treated as indicated. Detached cells from the bottom of culture plates by trypsin were pelleted by centrifugation and washed with phosphate-buffered saline (PBS). The pellet were suspended in extraction buffer and incubated on ice for 20 min then centrifuged at 10,000 × g for 10 min at 4°C. The supernatant represented the cytosolic protein. Add 10 μl of 10× reaction buffer and 5 μl of calpain substrate, Ac-LLY-AFC, to each assay. Incubate at 37°C for 1 h in the dark. After incubation, production of free AFC was fluorometrically measured suing a Victor 3 Multilabel Counter with an excitation filter of 400 nm and an emission filter of 505 nm (PerkinElmer, Boston, MA, USA).
Measurement of reactive oxygen species (ROS)
The intracellular generation of ROS was measured using DCFH-DA. The nonfluorescent ester penetrates into the cells and is hydrolyzed to DCFH by the cellular esterases. The probe (DCFH) is rapidly oxidized to the highly fluorescent compound DCF in the presence of cellular peroxidase and ROS such as hydrogen peroxide or fatty acid peroxides. Cells cultured in 24-well plate were preincubated in the culture medium with 30 μM DCFH-DA for 1 h at 37°C. After the preincubation, the cells were exposed to 30 μM silibinin for various times. Changes in DCF fluorescence was assayed using FACSort Becton Dickinson Flow Cytometer (Becton-Dickinson Bioscience, San Jose, CA, USA) and data were analyzed with CELLQuest Software.
Measurement of △ψm
The △ψm was measured with DiOC6(3), a fluorochrome that is incorporated into cells depending upon the mitochondrial membrane potential [10]. Loss in DiOC6(3) staining indicates disruption of the △ψm. Cells were stained with DiOC6(3) at a final concentration of 50 nM for 20 min at 37°C in the dark. Cells were washed and resuspended in Hank's balanced salts solution containing Ca2+ and Mg2+. The fluorescence intensity was analyzed with a FACScan flow cytometer using the fluorescence signal 1 channel.
Western blot analysis
Cells were harvest at various times after silibinin treatment and disrupted in lysis buffer (1% Triton X-100, 1 mM EGTA, 1 mM EDTA, 10 mM Tris-HCl, pH 7.4). Cell debris was removed by centrifugation at 10,000 g for 10 min at 4°C. The resulting supernatants were resolved on a 10% SDS-PAGE under denatured reducing conditions and transferred to nitrocellulose membranes. The membranes were blocked with 5% non-fat dried milk at room temperature for 30 min and incubated with different primary antibodies. The membranes were washed and incubated with horseradish peroxidase-conjugated secondary antibodies. The signal was visualized using an enhanced chemiluminescence (Amersham, Buckinghamshire, UK).
Measurement of AIF nuclear translocation
Cells were harvested and washed twice with PBS. The cells were incubated with extraction buffer (10 mM Hepes, 250 mM sucrose, 10 mM KCl, 1.5 mM MgCl 2 , 1 mM EDTA, 1 mM EGTA, 0.05% digitonin, and 1 mM phenylmethylsulfonyl fluoride) at 4°C for 10 min, then centrifuged at 100000 g for 10 min at 4°C. The supernatant cytosolic protein was removed and the pellet was incubated in the nuclear extraction buffer (350 mM NaCl, 1 mM EGTA, 1 mM EDTA, 10 mM Tris-HCl, pH 7.4, and protease inhibitors) at 4°C for 10 min, then centrifuged at 10000 g for 10 min at 4°C. Proteins were loaded onto a 12% SDS-polyacrylamide gels and transferred to nitrocellulose membranes. After blocking in 5% non-fat dried milk at room temperature for 30 min, membranes were probed with rabbit polyclonal anti-AIF antibody, followed by horseradish peroxidase-conjugated secondary antibodies. Bands were visualized using the ECL detection system (Amersham, Buckinghamshire, UK).
AIF nuclear translocation was further confirmed by immunofluorescence analysis. Cells were cultured on glass coverslips and treated with silibinin. Cells were washed twice with PBS, fixed with 4% paraformadehyde in PBS for 10 min, permeabilized with 0.5% Triton X-100 in PBS for 10 min. After washing twice with PBS, cells were blocked with 8% BSA in Tris-buffered saline Triton X-100 (TBST). Cells were incubated with rabbit polyclonal anti-AIF overnight 4°C and washed twice with TBST. Cells were incubated with FITC-conjugated secondary antibody (Jackson ImmunoResearch Laboratories, PA, USA) for 1 h, and the nuclei were counterstained with propidium iodide to ascertain AIF unclear localization. Cell were washed twice and visualized by using the confocal microscope (Leica, Wetzlar, Germany).
RNA interference (RNAi)
For AIF targeting, we used The BLOCK-iT™ Pol miR RNAi Expression Vector Kits (Invitrogen, Carlsbad, CA, USA) to facilitate the expression of microRNA (miRNA). miRNA sequences for AIF were designed using online software (BLOCK-iT RNAi Designer from Invitrogen). The target sequence was 5'-GTGCCTATGCCTACAAGACTA-3'. This single-stranded oligonucleotide generated a double-stranded oligonucleotide, which instructed into pcDNA™ 6.2-GW/EmGFP-miR vector. This vector contains EmGFP that allow identifying of the transfection efficiency using fluorescence microscopy. The construct pcDNA™ 6.2-GW/EmGFP-miR-LacZ was used as a control. Cells were transiently transfected with these plasmids using lipofectamine (Invitrogen).
Statistical analysis
The data are expressed as means ± SEM and the difference between two groups was evaluated using Student's t-test. Multiple group comparison was done using one-way analysis of variance followed by the Tukey post hoc test. A probability level of 0.05 was used to establish significance.
Results and Discussion
Effect of calpain inhibitor on silibinin-induced cell death
Role of calpain and protein kinase C (PKC) activation in ROS generation and cell death induced by silibinin
PKCs are a family of serine/threonine kinases which are involved in tumor formation and progression [14]. PKC isoforms cooperate or exert opposite effects on the process of apoptosis [15, 16]. PKC isoforms such as PKCα, ε, and ξ inhibit apoptosis, whereas PKCδ is involved in the process of apoptosis [16, 17]. Although previous studies have shown that flavonoids can induce activation of PKC [18, 19], it is unclear whether PKC is involved in the signaling cascade of silibinin-induced cell death. Although PKCs are activated by ROS [20, 21], it has been reported that PKC activation can also cause ROS generation [22, 23]. Therefore, we examined involvement of PKC in the silibinin-induced ROS generation. The general PKC inhibitor GF 109203X and the selective PKCδ inhibitor rottlerin blocked the ROS generation (Figure 2A). The silibinin-induced cell death was also prevented by the general PKC inhibitor GF 109203X and rottlerin (Figure 2B), indicating that silibinin induces ROS generation and cell death through PKC activation. We next examined whether silibinin induces PKCδ phosphorylation, an index of PKCδ activation. Silibinin induced a transient phosphorylation of PKCδ after 10 min of treatment, which was inhibited by treatment of calpain inhibitor (Figure 2C and 2D), suggesting that PKCδ may be a downstream of calpain in the silibinin-induced cell death. Similar results are reported in human U-937 leukemia cells in which the flavonoid wogonin induces cell arrest through PKCδ activation [18].
Role of Bax expression and mitochondria in silibinin-induced cell death
Disruption of △ψm by silibinin may be associated with ROS generation. To test the possibility, cells were exposed to silibinin in the presence of the antioxidant catalase and △ψm was measured. Figure 4C shows that the silibinin-induced reduction in △ψm was blocked by catalase, suggesting that the △ψm disruption by silibinin is mediated by ROS generation.
As shown above, since the silibinin-induced ROS generation was blocked by inhibitors of calpain and PKC, the silibinin-induced disruption of △ψm would be prevented by these inhibitors. As expected, the reduction in △ψm was blocked by Z-Leu-Leu-CHO, GF 109203X, and rottlerin, with similar potency to that by catalase (Figure 4C).
Role of AIF nuclear translocation in silibinin-induced cell death
The present study demonstrated that silibinin induces apoptosis through AIF nuclear translocation mediated by a calpain-dependent pathway in U87MG human glioma cells. This pathway involves PKC activation and ROS generation. These data suggest that silibinin may be considered a potential candidate in prevention and treatment of human malignant gliomas.
List of abbreviations
apoptosis-inducing factor
2',7'-dichlorofluorescein diacetate
- DiOC6(3):
3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide
phosphate buffer solution
protein kinase C
reactive oxygen species
- △ψm:
mitochondrial membrane potential.
This research was supported by Basic Science Research program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0003690) and a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family affairs (0920050).
Authors' Affiliations
- Ohgaki H, Kleihues P: Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol. 2005, 64 (6): 479-489.PubMedGoogle Scholar
- DeAngelis LM: Brain tumors. N Engl J Med. 2001, 344 (2): 114-123. 10.1056/NEJM200101113440207.View ArticlePubMedGoogle Scholar
- Sanai N, Alvarez-Buylla A, Berger MS: Neural stem cells and the origin of gliomas. N Engl J Med. 2005, 353 (8): 811-822. 10.1056/NEJMra043666.View ArticlePubMedGoogle Scholar
- Singh RP, Gu M, Agarwal R: Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. Cancer Res. 2008, 68 (6): 2043-2050. 10.1158/0008-5472.CAN-07-6247.View ArticlePubMedGoogle Scholar
- Singh RP, Mallikarjuna GU, Sharma G, Dhanalakshmi S, Tyagi AK, Chan DC, Agarwal C, Agarwal R: Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance. Clin Cancer Res. 2004, 10 (24): 8641-8647. 10.1158/1078-0432.CCR-04-1435.View ArticlePubMedGoogle Scholar
- Ramasamy K, Agarwal R: Multitargeted therapy of cancer by silymarin. Cancer Lett. 2008, 269(352-362.Google Scholar
- Kaur M, Agarwal R: Silymarin and epithelial cancer chemoprevention: how close we are to bedside?. Toxicol Appl Pharmacol. 2007, 224 (3): 350-359. 10.1016/j.taap.2006.11.011.PubMed CentralView ArticlePubMedGoogle Scholar
- Kim KW, Choi CH, Kim TH, Kwon CH, Woo JS, Kim YK: Silibinin inhibits glioma cell proliferation via Ca2+/ROS/MAPK-dependent mechanism in vitro and glioma tumor growth in vivo. Neurochem Res. 2009, 34 (8): 1479-1490. 10.1007/s11064-009-9935-6.View ArticlePubMedGoogle Scholar
- Denizot F, Lang R: Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods. 1986, 89 (2): 271-277. 10.1016/0022-1759(86)90368-6.View ArticlePubMedGoogle Scholar
- Pastorino JG, Chen ST, Tafani M, Snyder JW, Farber JL: The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem. 1998, 273 (13): 7770-7775. 10.1074/jbc.273.13.7770.View ArticlePubMedGoogle Scholar
- Orrenius S, Zhivotovsky B, Nicotera P: Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol. 2003, 4 (7): 552-565. 10.1038/nrm1150.View ArticlePubMedGoogle Scholar
- Huang Y, Wang KK: The calpain family and human disease. Trends Mol Med. 2001, 7 (8): 355-362. 10.1016/S1471-4914(01)02049-4.View ArticlePubMedGoogle Scholar
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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The more I watch the news, scroll through my Twitter and Facebook feeds, and listen to NPR, the more I wonder if peace is possible. The idea that we are progressing as a human race is simply folly. American bombs kill innocent aid workers in hospitals. ISIS displaces large segments of Iraqis and Syrians. Regular [Read More…]
Giving Up on Nonviolence: For Those Who Want to Believe Peace is Possible
Many American Christians Would Call for the Execution of St. Paul #KellyonMyMind
In no way do I want to create a one-for-one correlation between St. Paul and Kelly Gissendaner. Paul's violence was religiously motivated (always evil in light of Christ) and Kelly's was motivated by other things. But, the fact is that they do have one thing in common: they both committed unthinkable murders and they both found the light of God which changed them into dramatically loving people. [Read more…]
Story, Structure and Scripture: Reading the Bible in the 21st Century
KURT NOTE: The following is a guest post by Ryan Furlong. Deep stuff here! —————————————————————————– I suppose stories are vehicles for far more than we give them credit. Far from the typical plot diagram one's high school English teacher delineated on William Shakespeare's "Romeo and Juliet" or Nathaniel Hawthorne's The Scarlet Letter—outlining the discrete plot [Read More…]
Politicized Christology in Christianized Politics: "Constantinianism" of "Right" and "Left"
This is a guest post to get us thinking about political discourse as Christians. Thanks to Darrin W. Snyder Belousek for this great guest submission! ———————————— In a recent essay at The Week, Damon Linker responds to several writers in First Things who lament the triumph of "secular liberalism" and the demise of "civic Christianity" in [Read More…]


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Women's Green Military Dress
An ode to the military trend, this dress from T by Alexander Wang is idea for trans-seasonal dressing. Sporting a spread collar and half button fastening, two patch pockets on the chest add a contemporary touch. Pair with boots and a roll neck for stylish weekend dressing. US sizing. Spread collar. 2 patch pockets on chest. Short sleeves. Half button fastening. 98% cotton, 2% elastane. Dry clean. Color: green


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As an active Leadership Consultant Erik is responsible for
the Pi Kappa Phi chapters in an assigned region with respect to student and
chapter development, growth strategy/planning and volunteer activities/management. He hopes to add to the expansion of Pi Kappa Phi and its
mission to create better and stronger leaders on campuses across the country.
Erik graduated from Quinnipiac University in May of 2016. Located
in Hamden, Connecticut, Quinnipiac is a medium size school with an undergrad
population of around 8,000. He studied advertising, as well as earning a minor in
economics. He was heavily involved with recruitment during the time with his
chapter (Iota Lambda) before serving as vice archon his sophomore year into his
junior year. He also was elected chapter president of the American Advertising
Federation his senior year, and lead the chapter to compete in the National
Student Advertising Competition in Boston, Massachusetts.
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and even spent 9 days in Austria skiing during high school. In his free time,
Erik is an avid follower of soccer and proudly supports the Tottenham Hotspurs
(an English football club).
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Dr. Stephen Levin MD Patient Reviews
- Pediatrics Philadelphia, PA
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4 Patient Reviews
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5.0 of 5
July 9th, 2013
Great Doctor
Dr.levin is awesome I love his office an staff the nurses are all great and I have a good experience every time I Take my some to his appointments!!! Yes I would refer a friend or a family member !!!
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Very good doctor, would recommend him to any of my friends. Always very plesant.
5.0 of 5
February 23rd, 2012
Dr.Levin was my daughter's pediatrician and he has been grandaughter's pediatrician since birth. She adores him and so do we. We are prepping her that she will soon have to switch doctor's as she is now 17 years old and boy she is not excited aboutthe thought of leaving Dr. Levin. Dr. Levin is always calm ,polite and a very caring MD. He never hesitates to refer you else where if needed. Just a short story. A few years ago my grandaughter was having severe stomach pain. Dr. Levin didn't hesitate to say get her over to St. Christopher's hospital for Children. When we arrived the doctors were waiting for her and I could hear them talking about how her pediatrician called and saw how quickly they responded to getting her medically assessed. Every patient should be treated with the royalty that my granddtr received. We love you Dr. Levin.
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Dr. Levin is a great doctor, but his personnel SUCKS!! The young lady that sits at the front desk is rude and the medical assistant is NOT good with children. I wish he had better assistants.
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Mobor Beach Tourism & Travel Guide
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30 Best Beaches Of Goa That You Just Can Not Miss!
Credit: Maps Of India If a peaceful serene beach is what you seek, Mobor Beach is the place for you....
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10 beautiful photos of beaches in Goa
Kerim Beach: Beautiful view of Kerim Beach Arambol Beach: Sunset at Arambol Beach Chapora beach Morjim Beach: Beautiful sunset at Morjim Beach Anjuna Beach: One of the most popular beach of Goa Agonda Beach: Person doing yoga during sunset Baga Beach: Water sports at Baga Beach Bernaulim Beach Calangute beach Mobor Beach...
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Top Places To Visit 5 Spots
The Fishermans Wharf
At The Riverside, Salcette, Goa 403731, India
The Fisherman's Wharf on Mobor Beach is one of the best places to eat in south Goa. The restaurant's location on the river offers a great view, and the menu features some delectable seafood such as Prawn Recheado, Pomfret in Butter Garlic Sauce, and the classic Goan Prawn Curry with Rice. For those looking for more conventional options, the Fisherman's Wharf also offers Indian and Mediterranean options. Though this place is a bit costly, but it is well worth it.Cost for two: Rs 1,100
Mobor Beach
Mobor Beach, Cavelossim, Goa 403731
The last beach on our iternary was Mobor, the tip of the small peninsula. It was secluded, but that may be because the beachfront is mostly monopolized by a 'eco-friendly' luxury resort that is currently installing a grass lawn around its 'bamboo huts'.
Places To Stay 5 Places
About Mobor Beach
If a peaceful serene beach is what you seek, Mobor Beach is the place for you. Again, one of the best beaches of Goa - this one is a long stretch of seafront with few shacks and handicraft shops. Sunset is a no-miss if you happen to be there.
Best Time To Visit
Best time to visit Mobor Beach is from October to February
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Category page
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Here's a (as of yet) incomplete list of the major events in the Ghostbuster universe.
"Prior to the arrival of Gozer, Louis Tully was having a party with his clients. The refreshments...Louis's party
Pages in category "Events"
The following 7 pages are in this category, out of 7 total.


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Phil Broker is a former DEA agent who has gone through a crisis after his action against a biker gang went horribly wrong and it cost the life of his boss' son. He is recently widowed and is left with a 9-years-old daughter,Maddy. He decides to quit the turbulent and demanding life of thrill for Maddy's sake and retires to a small town. His daughter fights off a boy who was bullying her at school and this sets in motion a round of events that end in his direct confrontation with the local Meth drug lord. His past h...
Action, Crime, Drama, Thriller
6.5 from 84,021 users
Jason Statham, James Franco, Izabela Vidovic, Kate Bosworth, Marcus Hester
2013 (23 January 2014)
100 minutes
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Maiami detektīviem Maikam Lourijam un Markusam Brenē ir tieši trīs diennaktis laika, lai atrastu heroīna kravu 100 miljonu dolāru vērtībā, citādi viņi tiek atlaisti no darba. Likmes paliek vēl augstākas, kad viņu tuvu draugu nogalina narkotiku dīleri. Bet lieta kļūt vēl sarežģītāka, kad detektīviem ir jāpārliecina slepkavības lieciniece, ka ar viņiem ir vērts sadarboties....


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Fear or Myth: The Truth About Swimming
As the weather continues on this crazy streak from hot to cold and as the leaves start changing colors again and these winter months continue to fly by, I can't help to feel that summer is right around the corner. Summer happens to be my favorite season of all. I don't know? It could be that I'm a huge food addict and summer means hot dogs and hamburgers off the grill! Maybe it's the Italian ices that I can't get enough of or the long summer nights with those cool breezes. However if I had to choose my favorite thing about the summer, I would have to say it's my love for the water.
As far back as I can remember there never seemed to be a time when I didn't love the water. It's funny because my first time in pollywog class at the YMCA, sits in my head as if it was yesterday. I remember my mom being there cheering me on, I had to be about 6 or 7 years old at the time, and I jumped right in that water and knew from that day on that I would be inseparable from it. After pollywog class there were multiple classes that followed. I started to excel very fast and by the age of 13 was asked to become a junior lifeguard. If there was one thing I noticed while going through all my classes, was that in most of them I happen to be the only one that looked like me. I mean, yeah my sister and two cousins and I were in some classes together, but that doesn't count. Besides us, you hardly saw any other Black kids in the pool. I also started realizing that every time my friends or family and I would go to pools or beaches, we were the only ones who could swim out of most of the people we were with. Yeah everyone always say they can swim until they get in and can only do enough to get from one side of the pool to another. But what about real swimming? The kind that might actually save your life one day if ever in a really bad situation. And besides do you know how annoying it is to be in the deep end by yourself? I can't tell you how many places I've been and it never fails, I somehow always end up in the deep end by myself.
I started to think maybe it's me. Maybe I was just lucky enough to have a parent to even put me in a swim class or even lucky enough to have a parent at all. But as I did get older it started to honestly bother me a bit. You always hear Black people talk about the stereotypes: "Well Black people can't swim, Black people are afraid of the water, Black people don't go anywhere, Black girls don't like to get they hair wet." But how ignorant is that. I know plenty of Black people that do travel and aren't afraid of the water; and plenty of black girls who don't mind getting their hair wet. However there are millions of Blacks across the country who I don't know. Which leads me to think, how come it seems that so many people in the Black community can't swim? Is it that resources our limited to many in the community? Is it that if your parents don't know how to swim then naturally their children doesn't learn? There are many generalizations that can be made about this but facts are facts. I found that the best way to find out the truth is to research the actual rate at which kids in the Black community learn how to swim compared to other races, as well as to try to find out why those numbers are significantly different; if such.
- According to the American Academy of Pediatrics, "drowning is the second leading cause of unintentional injury-related deaths for those younger than 19 and can be prevented." It seems though, out of this concerning research, that African Americans in particular are vulnerable to this.
- Black children drown at a rate more than three times that of white children.
- 40% of white children have low or no swimming ability, while the same was true for 70% of African-American children based on a USA Swimming survey. Latino children also fall behind with 58 percent at low or no swimming ability.
- According to other recent surveys and studies commissioned by the national governing body of competitive swimming USA Swimming, it is true that African American parents who don't know how to swim are less than likely to persuade their children to swim.
- Surveys also found that African Americans state that access to pools and expenses for swim lessons also prohibit them from learning and in a sense discourages them.
- Also there is a wide suggestion with African Americans that swimming is culturally a white recreation.
- However based on recent surveys conducted by the University of Memphis and the YMCA from over 6 cities across the US the most popular reason stated by African Americans for not learning how to swim is: the fear of drowning.
Today more than ever, little to no programs geared towards minorities learning to swim are popping up across the United States. With every question comes an answer. Is fear really keeping us from swimming? Some may question is this even a relevant piece? Is there even any importance and need to know how to swim? Well I say YES! Who knows where your child may end up and what basic life skill may become a necessity in a need to survive. If we can start to get across that this is just one more life skill to acquire, that can not only save your life but broaden it; why shouldn't there be an importance to learn it? If fear seems to be one of the biggest factors in this whole theory, in 2012, I think this is just one more thing we can truly get over. . . . .
Related posts:
- "Airing Out the Family Business": A Look at Myth v. Facts in Our Community
- Wise words from an Alpha Male who is a RING-giver:
- "Young nigga go to school; stay away from me…": A Look at Our Role in the Racial Educational Gap
- 2011 is here!! Now what?!
- "$100,000 in start-up capital or Harvard?!": A Look at Peter Thiel and the Concept of Education


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Comedian Seyi Law declares his interest to run for president in 2019
Comedian Seyi Law declares his interest to run for president in 2019
The comedian took to his Instagram and twitter page to declare his interest in running for president come 2019. According to him, it's time we vote for shift and change the status quo. Read the rest of what he rote after the cut..
Why aim low when you can aim high? I believe that the status quo must change for Nigeria to regain its place as a force to reckon with. The energy and knowledge of the Nigerian Youth must be put to positive use.
It is time we acknowledged the ingenuity of our vibrant men and women to ensure proper representation at the different levels of governance and not mere reduction to PAs and SAs.
We must ensure we retain our best brains in the country and adequately make provision to reform our educational institutions, healthcare system and industries. Our ways of learning must change to meet required standard.
I am ALETILE OLUWASEYITAN LAWRENCE aka SEYILAW and I am running for the highest office in the land in 2019.
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There have been two warnings in a little over a month about the dangers of eating lots of red meat. The first, a huge European study, suggested a strong link with bowel cancer, and now a smaller British study has found a powerful association with the inflammatory bowel condition Crohn's disease.
Now consider this puzzle. Mormons and Seventh-Day Adventists lead similar lifestyles - they don't smoke, they don't drink and they go to church. But there is a key dietary difference: Mormons eat meat while most Seventh-Day Adventists are vegetarians.
If red meat is a major cause of bowel cancer, then Mormons ought to have higher rates of the disease. But they do not.
Some commentators think this demolishes the claims of scientists who would have us cut down on meat-eating. It doesn't - but it does highlight the difficulty of establishing clear causes. There are only two really significant causes of cancer - smoking and getting older. Everything else pales into insignificance by comparison. With lesser causes, such as red meat, other mitigating factors play a greater role - genetic inheritance, exercise, other elements in the diet.
So how should the average meat-eater respond to the latest research? The warning on red meat is worth heeding because of the place animal flesh plays in the typical Western diet. You do not need to eat steak three times a day to notch up a surprising tally in grams of red meat. The simplest advice, therefore, is not to abandon meat but to think more like a vegetarian - not a pulse-promoting obsessive, but one who cheats with an occasional bacon butty or steak and chips.
As a counter to the evidence from the Mormons and Seventh-Day Adventists, it is worth noting that bowel-cancer rates have risen sharply among the Japanese as they have adopted a Western diet.
Last month's study was the largest ever conducted into the health effects of Europe's passion for meat. Called the European Prospective Investigation into Cancer and Nutrition (Epic), and funded by the UK Medical Research Council and Cancer Research UK among others, it involved 500,000 Europeans in 10 countries whose diets were monitored for five years. The results, published in the Journal of the National Cancer Institute, showed that those who ate two portions a day of red meat - beef, lamb, pork, veal and their processed varieties, ham and bacon - had a third higher risk of developing bowel cancer than those who ate one portion a week.
The high-risk group were eating more than 160 grams of red meat a day - equivalent to two large beef burgers (80 grams each). The average Briton eats 93 grams of red meat a day according to British Meat, allowing it to claim that there was no reason for most people to change their habits. "If you eat meat you are not going to get cancer," a spokesman said.
It is a fair claim. Man has been eating red meat for millennia. But aside from the fact that we live longer now - long enough to develop cancer - we also probably eat more meat than our ancestors. Red meat is also high in fat, which increases the risk of heart disease, providing an added reason to cut down.
In many parts of the world, and in some Mediterranean countries, meat is regarded as a relish or a treat, with the bulk of the meal coming from carbohydrates and vegetables. In contrast, a modern office worker grabbing a bacon sandwich to start the day (two rashers at 30 grams each), eating sausages for lunch (two at 40 grams each) and lamb chops in the evening (80 grams) can quickly ramp up his or her red meat quotient without going near a Big Mac or a steak and chips.
The study showed that the effects of meat-eating were lessened among those who ate plenty of fibre in the form of vegetables and fruit. Those who ate fish every other day also cut their risk.
Doctors believe up to two-thirds of bowel cancers could be prevented by changes in diet and lifestyle. But there is no magic bullet as there is with lung cancer (by cutting out smoking). Defeating bowel cancer will require a multi-pronged approach - changing aspects of diet and lifestyle (especially smoking and drinking, which also contribute to bowel cancer) across a wide front.
The second, smaller study published last week, by researchers at the University of East Anglia, followed the diets and lifestyles of 218 patients over two years and found a 40 per cent increased risk of Crohn's disease among meat-eaters.
The Food Standards Agency has asked its food safety advisers to examine the findings and consider what further research may be necessary. But the agency reiterated its advice that red meat had a place in a balanced and varied diet because it was a good source of iron, zinc, B vitamins and protein. It also pointed out that as we typically eat meat with vegetables and potatoes, we get the fibre that protects against bowel cancer. Maintaining levels of iron is a priority for women, who lose the mineral with each monthly period, and are at risk of anaemia.
About 35,000 cases of bowel cancer are diagnosed each year in the UK, with men slightly more likely to get the disease than women. It is the third most common cancer in men - after cancers of the lung and prostate - and the second most common in women after breast cancer.
Any measure that can reduce this toll without adversely affecting quality of life has to be worth thinking about. If it is right to revere the roast beef of Old England - it is worth saving it for special occasions.Reuse content


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Law enforcement authorities are increasingly advising school officials — and even young students — to physically confront suspects in future campus attacks as a final line of defense.
The advisories, now included in training videos and documents prepared by police, represent a major shift in tactics for law enforcement officials who have traditionally counseled potential victims to flee and hide while waiting for authorities to answer calls for help.
"These incidents are becoming a fact of life," University of Wisconsin-Madison Police Chief Susan Riseling told a meeting of law enforcement colleagues gathered here. "If there is no other option, take the shooter out."
Riseling, who has produced an instructional video on dealing with so-called "active shooters," said that while police have long urged potential victims to avoid such confrontations at all costs, recent mass shootings are forcing a controversial change in the ranks.
Read the rest at USA Today


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"Why did you choose this product?"
Very beautiful and imposing, all my friends want it!...
Michael Valitutti Two-tone Multi-gemstone Manhattan Stackable Ring Setby Michael Valitutti
ITEM#: 14803613This exquisite Michael Valitutti stackable ring set features a beautiful combination of gemstones including blue topaz, amethyst, citrine, London blue topaz, peridot and garnet. Crafted of palladium silver with a beautifully-constructed undergallery, this jewelry is embraced by 18-karat yellow gold detailing.
- Gemstone colors: Black, blue, purple, red, green, orange
- Gemstone shapes: Cushion, round, princess, emerald
- One prong-set cushion-cut hematite measures 6 mm wide x 8 mm long
- One prong-set princess-cut blue topaz
- One bezel-set princess-cut amethyst
- One bezel-set emerald-cut amethyst
- One bezel-set round-cut citrine
- One bezel-set round-cut London blue topaz
- One bezel-set princess-cut peridot
- One bezel-set princess-cut garnet
- Metal: Sterling silver, palladium, 18k yellow gold
- Finish: High polish
- Band dimensions: 2 mm wide, each
All carat weights and measurements are approximate and may vary slightly from the listed dimensions. Treatment code N (amethyst, garnet, hematite, peridot), H (citrine, ruby, blue topaz, blue sapphire) and R (london blue topaz). See Treatment Guide for further information.
Click here for ring sizing guide
This ring cannot be resized.
|Sterling Silver
|Ring Style
|Bands, Cocktail-Cluster, Stackable
|Stone Shape
|Baguette, Cushion, Oval, Princess, Round
|10, 11, 5, 6, 7, 8, 9
|See Details
|Model Number
|Country of Origin
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Nicer than pictured
This ring is a keeper. I am sadly finding out that sizing for this jewelry is not consistent. Order up a size for Valitutti. I think it has to do with the thickness of the shanks, but other than that, most items are gorgeous. Valitutti is quite an artist! I've sadly missed out on a couple of rings because of sizing. This ring sparkled, the colors are rich and I'm so glad I got a size 10 for my size 9 middle finger! My favorite ring!Read More
Sparkling Stunner!
I had searched high and low looking for the perfect go with everything right hand ring and THIS IS IT! I had been to every jewelry and department store in the malls and to several places online and was thrilled to find this ring, the perfect ring, on O.Co, great selection, great value, prompt delivery, perfect transaction., I couldn't be happier. This ring is super sparlkley without taking over my hand, The weight of it is very comfortable, and sizing was quite good as I typically wear a 5 1/2, ordered a 6 and it stays in place without turning as some rings tend to do, mega comfortable. I am 100% delighted with this purchase.Read More
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very beautiful!
Very beautiful and imposing, all my friends want it!Read More
item shipped to wrong address never got to see it
cant believe what just happened. I live in florida. item was shipped to Denver, Colorado had to chat 2 xs to get refund started, never did they try to retrieve ring. now out of stock. lost much confidence in company. not a happy camperRead More
duh....of course!
anything michael v. makes, is wonderful! very creative man and won many awards too! i love his jewelry and am so glad i can get it here instead of shopnbc! i love that he mixes the silver with palidum and you do not have to polish silver, it's a good mix. anything he makes, do not hesitate to purchase!Read More
Questions & Answers
Each individual ring is fully detailed. Not that common in a stackable set.
"what is the size of this ring?"
Hello, georgene729. Hope your day is going well. There are only 2 sizes left----5 and 6. To select, you would access the blue option box at the upper right of the page. Thank you for shopping with us and please feel free to contact us again with any further questions.
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Learn more about aquamarine and how to select the highest quality gem when shopping. Get great deals on aquamarine jewelry at Overstock.com.
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Iolite Jewelry Fact Sheet
Iolite Jewelry Fact Sheet from Overstock.com. Our guides provide customers with information about iolite jewelry.
Gemstone Jewelry Buying Guide
Gemstone Jewelry Buying Guide from Overstock.com. Our guides provide customers with information about gemstone jewelry.
Best Gemstones to Wear Now
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An Introduction to Lab-Created Gemstones
An Introduction to Lab-Created Gemstones from Overstock.com. Are lab-created gemstones real? How are they made? What do I look for when I'm shopping? All your questions about lab-created diamonds and other gems are answered here.
How to Care for Coral Jewelry
How to Care for Coral Jewelry from Overstock.com. Our guides provide customers with information about how to care for coral jewelry.
How to Care for Gemstones
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How to Clean Jade Jewelry
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How to Draw Batman, Superman, and Other DC Super Heroes and Villains
Written by Aaron Sautter
Illustrated by Tim Levins, Erik Doescher
Part of the DC Super Heroes Series
Lovereading4kids Price £13.59
£16.99 saving £3.40 (20%)
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How to Draw Batman, Superman, and Other DC Super Heroes and Villains by Aaron Sautter
About the Author
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Paperback / softback
144 pages
Aaron Sautter
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Capstone Press
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9th April 2015
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Anybody tried Sergeant Sally + Power Overwhelming with this ?
3 Cards 7 Mana for 5 AoE damage and 8-8 body sounds reasonable.
[x]Battlecry: Destroy both
adjacent minions and gain
their Attack and Health.
If you put this into your deck, you WILL lose the trust of your other minions.
Anybody tried Sergeant Sally + Power Overwhelming with this ?
3 Cards 7 Mana for 5 AoE damage and 8-8 body sounds reasonable.
po+brann= FeelsGoodMan
My favorite card in the game. Synergizes with power overwhelming, nerubian egg, haunted creeper, voidcaller, etc.. Best card for zoo IMO
i like golden animation
do you like portrait too?
This + Nerubian egg + power overwelming is my favorite combo
Very great card. Super combo with Poweroverwelming than face check followed by Voice Terror consumption aka GG!
As of right now the Void Terror is a little-used card in any variety of Warlock deck. However, with the deathrattle-themed Naxxramas Adventure coming this summer, I expect it to become a lot more prominent! For instance, imagine using a Void Terror on turn 3 to hatch a turn 2 Nerubian Egg...
essential card in warlock deck
Absolutely not. Never seen in competitions and very unreliable. Fun, though :)
You both are wrong. It has very strong combos in zoo decks, but since you only get reasonable value out of it in zoo, it's not essential.


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Emily Dickinson Birthday Tribute With Poet Peter Gizzi
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Celebrate Emily Dickinson's 183rd birthday with Peter Gizzi (Threshold Songs), a poet who has been called Dickinson's modern-day heir. Gizzi will be discussing the great American poet's legacy, in addition to reading from his own work. Hovering between grief and joy, the abstract and the concrete, Gizzi's poetry explores the hardships and pleasures in life. A former poetry editor for The Nation, Gizzi has garnered numerous awards and fellowships, and has taught at Brown and the University of Massachusetts at Amherst.
* Additional fees apply. No coupon or promo codes necessary to enjoy the displayed discount price.
All offers for Emily Dickinson Birthday Tribute: Peter Gizzi have expired.
The last date listed for Emily Dickinson Birthday Tribute: Peter Gizzi was Monday December 9, 2013 / 7:30pm.
Currently at Folger Theatre
Timon of Athens: Shakespearean Satire on the Price of Prosperity
- Full Price:
- $30 - $75
- Our Price:
- $21 - $52.50
Shakespeare's tragic and ever timely satire on the steep price of prosperity tracks the fall of a… More
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Analysts argue that the C&W deal, which gives its telecommunications subsidiary Mercury access to a potential 6 million homes in cable areas currently run by Bell Cablemedia, Nynex CableComms and Videotron, could work to BT's advantage by emphasising that customers will for the first time have a genuine choice of service provider.
However, government sources yesterday discounted the chances of the policy, which the Conservatives have stuck to since the telecommunications industry was thrown open to full competition in 1991, being changed before the next election.
According to one senior government source, the ministerial view remains that ban on entertainment services is the spur to the pounds 2bn investment made by cable operators in the UK each year. "We know BT's view on this and they know our view. Nothing has changed," the source said.
BT has equally defended its argument that it can only justify investing pounds 15bn in providing fibre optic cables to residential customers, replacing existing copper wire technology, if it is able to pack extra services down the infrastructure.
The official policy has two strands. First, BT's ban on conveying broadcast pictures to local customers will be reviewed in 1998. Three years later, in 2001 and 10 years after the first combined cable and telephones franchises were awarded, the exclusion preventing BT from providing programming services will also be reviewed. There are no guarantees that either ban will be lifted.
One possibility is that an incoming Labour government could take a more favourable view of BT in the light of last year's controversial "deal" with the company announced by Tony Blair to cable up the country's schools.
The broadcast entertainment ban also applies to Mercury should it try to offer broadcast entertainment on its much more limited network, but C&W has dramatically circumvented this by taking over a block of cable franchises.
BT is not prevented from running some television pictures down its network as long as they are not broadcast contemporaneously, but its experiments with video-on-demand have apparently been disappointing.
In a trial of 2,500 households in Colchester and Ipswich, which ended in June, customers were able to order feature films or go home shopping with several leading retailers. The experiment proved for the first time that television pictures could be sent down existing copper telephone wires, which have a much lower capacity than the co-axial cables laid by cable operators.
However, BT has refused to divulge how many households actually used the services on offer and whether a country-wide service could be commercially viable. There are no plans to widen the trial further in its present form.
- More about:
- Internet
- Orange
- Telecommunications


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Hiring an Internet Marketing Service – Plan Before You Leap!
A regular slip-up that organizations make is contracting a web advertising organization too rapidly – essentially in light of cost. Your site is a visual representation of your business and an inadequately planned site can baffle guests, distort your items and even lose deals. Before you employ a web promoting firm, inquire about the responses to these inquiries:
1. The amount Experience Does The Internet Marketing Company Have? Do They Have Any Special Qualifications Or Designations?
Life span in the business is a decent marker of dependability and ability. Web advertising firms that have been in the business for some time and manufactured praiseworthy notorieties are generally known for sound configuration work and client administration. Picking a web showcasing organization that has been around longer means they will probably be around later on for continuous support and overhauls to your site.
The response to this inquiry will give you a general thought regarding the expertise set at the web organization. Having a tertiary capability is great. Having a great deal of experience is better, and joining knowledge with a tertiary instruction is ideal.
2. What number of Staff Members Do They Have And What Are Their Roles?
Greater is not inexorably better with regards to powerful web emarketing organizations. Organizations by and large have one fashioner, two or three web designers, investigators, and a couple of offers and bolster individuals. A few organizations utilize Just-in-Time staffing, including or evacuating staff as required. This keeps overhead low.
3. In Addition To Internet Marketing, What Other Services Does The Agency Offer?
Numerous noticeable web advertising firms are stretching out and offering different administrations, including web advancement and configuration. SEO, Search Engine Marketing, Web Content Writing, Social Media Marketing, Blog advancement, and Google AdWords Management are administrations offered by numerous accomplished internet advertising organizations. The key is finding an organization that offers the administrations that you are searching for.
4. Does The Internet Marketing Firm Spend Time With You To Gather Business Knowledge And Give You A Formal Proposal?
It regards select a web showcasing organization that will take an ideal opportunity to offer a custom answer for your site. As a rule, the web advertising firm will furnish you with a survey to round out so they can improve feel for your objectives, rivalry and general site needs. Your site will have huge impact in your general image promoting. Along these lines, it is critical that your web promoting firm have an unmistakable photo of your general web advertising objectives.
5. What Are the Internet Marketing Company's Payment Terms?
For anything from a little non-benefit webpage to full corporate marking, most web advertising organizations will charge a forthright store and stage installments taking into account concurred points of reference and deliverables. Be careful about any web promoting firm that requests installment in full before beginning the venture.
6. What Is The Internet Marketing Company's Policy On Non-Disclosure And Privacy Of Information?
Keeping in mind the end goal to make the ideal advertising arrangement for you, your web promoting firm needs access to imperative data about your organization – data you wouldn't need your opposition, or any other individual, to know.
This is especially valid in the event that you are beginning another organization. You don't need others to take your idea before you've had an opportunity to adapt it. In this way, a strong non-revelation and security approach will ensure your data.
7. What Are The Average Timelines For Completing Your Web Design Project Including Ecommerce, Logo Design, And Corporate Branding?
In the event that the organization does both web advancement and web promoting, ask what the firm considers an average pivot time for undertakings comparable in size to your own. This ought to give you a genuinely clear thought if the site creator/engineer has time following and venture administration frameworks set up. On the off chance that you have a hard due date that you have to meet, make sure you tell the configuration organization in advance so they can arrange likewise.
8. Who Will Be Your Central Point Of Contact For Your Internet Marketing Project?
It is essential to have a solitary purpose of contact for your undertaking to guarantee nothing loses all sense of direction in interpretation. A Project Manager ought to be doled out to all web ventures. On the off chance that you are working with a little web organization, in any case, the Project Manager may likewise be the web creator and/or web engineer himself.
9. Does The Company Outsource Any Project Components To Third Parties Or To Countries Like India? Assuming this is the case, Which Components?
While outsourcing might be a substantial business choice to spare expenses and keep overheads lower, you'll need to be wary of any web showcasing organization who takes your venture and out-sources expansive segments to another nation. In the event that you have worries about low quality, shoddy work, and remote undertaking administration issues when employments are outsourced to India, make certain to bring them up before your venture starts.
10. Could The Internet Marketing Company Help With Website Content Copy Writing?
SEO copywriting can represent the moment of truth your site. Your site outline may attract the peruser and center their consideration where it should be – yet the words themselves do the offering. What's more, if the substance is streamlined accurately, your site can appear on the front pages of the web search tools for your picked look terms.
Make certain the web showcasing firm you pick offers copywriting and request that see tests – especially tests of destinations inside your same industry. This will give you a decent establishment on which to base your choice.
11. What Programming Languages And Operating Systems Does The Internet Marketing and/or Web Development Company Work With?
In a perfect world, your web advancement organization ought to offer both the open source PHP/MySQL and ASP.NET programming dialects. They ought to make a specialized proposal on which
Stage would best address your issues and spending plan.
12. Do The Internet Marketing And Web Development Experts Build Websites To Web Standards?
Norms consistence, for example, W3C and Web Standards Group are exceedingly prescribed industry rehearses. The fundamental reason is consistency in how your guests see your site on various stages and future sealing.
13. What Is Covered In The Firm's Website Testing/Quality Checking Phase? It is safe to say that you are Able To See The Website While It Is Still In Development?
Essential testing necessities ought to be program trying, checking for broken connections and general ease of use tests to guarantee the site is simple for site guests to utilize and collaborate with.
By seeing an advancement arranging form, you will have the capacity to check the site before the dispatch date and make any essential conformities.
14. Does The Internet Marketing Firm Allow Clients To Host Their Websites With Any Host?
Once in a while, for usefulness or other great reasons, a web organization may ask that you have your site with them, yet this is not generally the situation. You may have existing business associations with an ISP or web facilitating organization that you would like to utilize. It is critical to know before procuring a web advertising firm in the event that they will oblige you to move facilitating to them.
15. Do They Provide Any Training Once The Website Is Launched?
In the event that your site venture incorporates redid frameworks or programming, it can be to a great degree accommodating if your web promoting organization gives you with preparing records to future reference. On the off chance that your framework is exceptionally point by point, it may even be ideal to orchestrate a preparation program or progressing client support.
16. Is The Internet Marketing Firm Knowledgeable in Web 2.0? It is safe to say that this is Included In Your Quote, Or Are There Extra Charges?
Website streamlining (SEO) is a science in itself; an accomplished Internet showcasing organization ought to have the capacity to offer you an assortment of choices including natural, PPC and online networking promoting including Facebook publicizing. Contingent upon your business prerequisites, you ought to think about procuring as a web promoting organization that can make a custom online crusade to help you accomplish most extreme results.
Normally there is an additional charge for single things like creating recordings, plugs and advertisements, photograph shoots, copywriting et cetera. Inquire as to whether they are a piece of your advertising arrangement.
17. What Is The Charge For Website Updates After The Initial Website Is Completed?
While showcasing is a progressing procedure, the site is frequently viewed as a one-time exertion. Be that as it may, there is constantly additional work to be done: changes and overhauls, new substance et cetera.
Know about the charging structure for overhauls to your site. Consider how frequently you will require overhauls and ask the web showcasing firm how they handle future upgrades and upkeep.
On the off chance that you have incessant or vast upgrades to your site, you could consider a Content Management System. A CMS is just truly valuable in case of customary changes and if a staff part has great preparing in it. On the off chance that nor are the situation, it might simply be less expensive to have the supplier to oversee little upgrades.
18. Imagine a scenario in which You Find A Problem Or Code Bug After The Site Is Finished. Does The Graphic Design Company Have Any Kind Of Code Warranty Or Guarantee?
Frequently web organizations will roll out the improvement in the event that it is little for no extra expenses. In any case, know that on the off chance that it is a change and not a bug fix, you might be required to pay additional. Ordinarily, web showcasing organizations will give you a few plans to support at first and after that include you consistently. Each endorsed area of the venture is viewed as wrapped up. Doing a reversal and rolling out improvements – regardless of the fact that they appear to be basic – can be exorbitant.
19. Is The Copyright For The Website Transferred To You When The Project Is Complete? Shouldn't something be said about Images in The Website? Logo Design?
Copyright law is a specific legitimate field. You ought to request that claim the copyright on the greater part of the work composed and created after


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Mon, 28/01/2013 - 06:05
Eurex Group has made management changes at both Eurex Repo and Eurex Bonds. Peter Reitz, who has served as managing director at both since 2006, has left both firms. However, he will continue to bear overall responsibility for the two subsidiaries on the Eurex executive board.
Fri, 25/01/2013 - 16:04
Institutional investors are entrusting a smaller portion of assets to leading broad managers, according to a report released by Cogent Research.
Fri, 25/01/2013 - 12:29
David A Sussman has joined Duane Morris's corporate practice group as a partner in its Newark office.
Fri, 25/01/2013 - 10:15
Brian Wilson and Greg Simonian have joined Ramius, the investment management subsidiary of Cowen Group, as directors responsible for distribution of alternative mutual and hedge fund products in the East Coast and Central regions, respectively.
Fri, 25/01/2013 - 06:41
Apex Fund Services, one of the world's largest independent fund administration companies, has continued its expansion into the LatAm markets with the opening of a new office in Montevideo, Uruguay.
Fri, 25/01/2013 - 06:00
Hedge fund investor flows were negative in December, capping a volatile fourth quarter in terms of asset movement by investors, according to a report from Evestment.
Thu, 24/01/2013 - 11:59
The fine wine market showed further signs of a recovery in prices during December, according to data released by The Wine Investment Fund (TWIF).
Thu, 24/01/2013 - 11:50
Options, a provider of the Options PIPE Private Financial Cloud services platform for the exchange, banking, trading and investment communities, has named former NYSE Euronext executive Danny Moore as chief operating officer.
Thu, 24/01/2013 - 10:10
Corporate credit and high yield specialist Muzinich & Co has appointed an emerging market corporate debt portfolio manager.
Thu, 24/01/2013 - 06:04
Continuum Investment Management, an asset management firm focused on investing in the structured fixed income market, has formed a partnership with Grosvenor Capital Management, one of the oldest and largest global alternative investment managers with over USD22bn in assets under management.
Copyright © 2017 GFM Ltd. All Rights Reserved


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"Fat Man"
Description: William Conrad starred as Jason Lockinvar McCabe, aka the "Fat Man" (also called "Buster"), a prosecuting District Attorney who chases down criminals in Los Angeles and later Honolulu with the assistance of his partner, Jake Styles (Joe Penny) on the detective drama JAKE AND THE FAT MAN/CBS/1987-91.
J.L. McCabe lives in a large Southern California city (presumably Los Angeles) until he retires as D.A. and moves to Hawaii where he works as an undercover investigator for the Honolulu prosecutor's office. A year later, McCabe moves back to Los Angeles when J.L. is offered his old job back.
Throughout the series, McCabe is accompanied by Max, his lugubrious English bulldog whose portly presence reflects his master's own girth.
Note: William Conrad and his "Fat Man" character was spoofed on episode "Petarded" Season 4; Episode 5 (2005) of the cartoon series FAMILY GUY as Peter and Brian Griffin watch a TV segment of JAKE AND THE FAT MAN where McCabe is depicted as being so obese that he can barely move.
British radio/TV personality Tom Vernon starred in a series of travelogues sponsored by PBS and Britain's Channel 4 Television in which he was called the FAT MAN as he biked about the world in search of Epicurean delights (Food, y'all).
In 1987, FAT MAN GOES NORSE visits towns in Norway and eats smoked reindeer. In the 1990s, FAT MAN GOES GAUCHO bicycles a thousand miles and feasts on the Argentinean cowboy delicacy—fried bull's testicles...Gulp! With all of his bicycling bravado, the blimpy brit still weighed in at 250-295 pounds.
Brad Runyon (J. Scott) was the star of the radio series "The Fat Man" created by Dashiell Hammett and based on his magazine detective "The Continental Op."
In the film Abbott and Costello Meet Captain Kidd (1952), Charles Laughton remarks, "I hate fat people!" When reminded of his own girth, he responds, "Hate myself, too!"
In military terms, "Fat Man" was the name bestowed on the Atomic Bomb (11 feet long by 5 feet in diameter) dropped onto the Japanese city of Nagasaki August 9th 1945. Reportedly, it was nicknamed after the British politician, Winston Churchill. Another report explains that American physicist Robert Serber said in his memoirs that the "Fat Man" bomb was named after Sydney Greenstreet's character of "Kasper Gutman" in The Maltese Falcon (1941).
See also - The Honeymooners; The Last Boy Scout; White Men Can't Jump


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Media Manager Online: Open Edition
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Type Value Period Entrepreneur ABC 17,856 2016-10-01 - 2016-12-31 Entrepreneur: Franchise Zone Carrying title 18,394 2015-04-01 EntrepreneurMag.co.za Effective Measure: Website 225,134 2017-02-01 - 2017-02-28
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