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Women's Metallic Stella Ring
Two diamond pear shapes floating between your fingers - what more could you ask for? Pair it with our Throne Ring and everything you hold will look as glam as an Academy Award. 0.50 carats. If you are in between sizes, order the size down. Color: metallic


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A well presented 2963sqft four bedroom, three bathroom detached house in this sought after private estate set in 25 acres of communal grounds with three tennis courts. EPC:C
An attractive five bedroom detached family house in this sought after location set in a 0.30 acre plot including rear garden with open views over bordering fields and towards the North Downs. EPC:D
SOLD BY HAMPTONS - An attractive five bedroom village house with a southerly facing garden situated in a delightful sought after location a few moments from Brockham village green. EPC:E
This double fronted detached chalet four bedroom chalet bungalow situated in this sought after village location between Dorking and Reigate. EPC:D
Due to the fast moving pace of the Short Let market, many of our properties never make it to the website. If you can't find what you're looking for, please give our Short Let team a call as we may have the ideal property for you.

subset: commoncrawl


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ean Stage Authors and Composers, each with rights to the music of various artists. Competition The company competes with HBO/Cinemax, Showtime, and EPIX, as well as Netflix, Amazon, iTunes, and Hulu. Starz Distribution segment This segment includes the operations of the company's Anchor Bay Entertainment, Starz Digital, and Starz Worldwide Distribution businesses. Sales and Distribution Anchor Bay Entertainment is the global home video sales arm of the company and distributes DVDs (standard definition and Blu-ray) under the ANCHOR BAY brand, in the U.S., Canada and other international territories to the extent the company has home entertainment rights to such content in international territories. Anchor Bay Entertainment acquires and licenses various titles from third parties, and also develops and produces certain of its content. Certain of the titles acquired by Anchor Bay Entertainment air on Starz Networks' STARZ and ENCORE networks. Anchor Bay Entertainment also distributes Starz Networks' original series and Weinstein's titles. Each of these titles are sold to and distributed by regional and national retailers and other companies, including Amazon, Best Buy, Ingram Entertainment, Netflix, Redbox, Target and Wal-Mart. Consistent with the Hollywood studios, Anchor Bay Entertainment has a direct vendor relationship with the major North American retailers (Best Buy, Target, Wal-Mart, etc.). Starz Digital is the global digital and on-demand licensing arm of the company and distributes content on pay-per-view, video-on-demand, subscription video-on-demand, ad-supported video-on-demand, electronic sell-through and other digital formats for the company's owned content, including Starz Networks' original series, Weinstein's titles and content licensed from third parties in the U.S. and internationally to the extent it has rights to such content in international territories. Certain of the titles acquired by Starz Digital air on Starz Networks' STARZ and ENCORE networks. Starz Digital receives fees for its content from a range of partners ranging from traditional MVPDs to online and mobile distributors. Starz Worldwide Distribution is the global television licensing arm of the company and distributes movies, television series, documentaries, children's programming and other video content. Starz Worldwide Distribution exploits the company's owned content, including Starz Networks' original series, and content for which it has licensed rights on free or pay television in the U.S. and internationally to the extent it has rights to such content in international territories. Starz Worldwide Distribution receives fees for its content primarily from various U.S. and international programming networks. Marketing The majority of Starz Distribution's marketing is performed by Anchor Bay Entertainment, which markets and advertises each title prior to and during release generally through the use of a combination of television and other media related advertising and discounts, rebates and cooperative advertising with retailers depending on the specific genre, demographic appeal and the overall sales expectations for the title. Twentieth Century Fox Home Entertainment LLC (Fox) Agreement Anchor Bay Entertainment has outsourced all of its home video fulfillment services, including DVD manufacturing and distribution, to Fox. Anchor Bay Entertainment does not outsource its sales or marketing functions and maintains its own marketing team and sales force. The agreement with Fox provides supply chain efficiencies due to the combined volume of titles provided by Anchor Bay Entertainment and Fox (Fox also has fulfillment agreements with Lionsgate and MGM), while not compromising Anchor Bay Entertainment's control on its products and retail relationships. Weinstein Agreement Anchor Bay Entertainment has a license agreement with Weinstein for the distribution, by Anchor Bay Entertainment and Starz Digital, of certain of Weinstein's theatrical titles through April 2020. Anchor Bay Entertainment earns a fee for the distribution of such theatrical titles. Competition Starz Distribution competes to sel
starz - b (STRZB:NASDAQ GS)
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realmagick.com The shrine of knowledge.
Poor Law The Act Of 1601
A selection of articles related to poor law the act of 1601.
Original articles from our library related to the Poor Law The Act Of 1601. See Table of Contents for further available material (downloadable resources) on Poor Law The Act Of 1601.
- The Aeonic Perspective of the Enochian Temples
- The initiatory system of the Enochian Temples divides the path of initiation into four major stages, distinguished primarily by the types and sources of the influences they are sensitive to. Briefly, these stages are: 1. Lunar-planetary, focused in Yesod and...
Magick >> Enochian
- Bringing it Down to Earth: A Fractal Approach
- 'Clouds are not spheres, mountains are not cones, coastlines are not circles, and bark is not smooth, nor does lightning travel in a straight line.' B. Mandelbrot W e want to think about the future - it's our nature. Unlike other creatures, humans possess an...
Mystic Sciences >> Astrology
- Mother Of The Gods And The Father Of The Gael
- There is no surviving, or as yet translated, Creation story within Irish mythology. We learn from the Lebor Gabala Erenn, a text from the Christian Middle Ages, of the Tuatha De Danann, or "People of the Goddess Danu", who came to Ireland either...
Deities & Heros >> Celtic, Welsh, Irish & Brittish
- Select Cross-Cultural and Historical Personifications of Death
- This extensive introduction includes some of the more well known, along with some lesser known Death "incarnations", and I use that term loosely, as in many cultures, the Angel of Death can be quite an adept shapeshifter. We have tried to cull...
Mystic Sciences >> Necromantic Studies
- The Celtic Vedic Connection, Part I
- Of all the great ancient cultures perhaps no two share more parallels than those of the Celtic and Vedic peoples. A deep rooted affinity runs between them, what is present in one is mirrored in the other. Myths, Gods, Goddesses, even fairy tales bear a...
Religions >> Druidism
Poor Law The Act Of 1601 is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Poor Law The Act Of 1601 books and related discussion.
Suggested News Resources
- Women have little relief from harassment despite laws
- A local NGO "Madadgar National Helpline" had claimed that at least 1,601 women were killed in Pakistan in the name of honour or for other reasons in 2013. According to data provided by this NGO, at least 370 women were ...
- The terrible beauty of the Easter Rising remains alive today
- And in fact the rebels suffered remarkably few casualties: just 16% of the dead of Easter week were rebels, and most of the casualties were poor slum dwellers caught in crossfire and in British shelling. As Patrick Pearse .....
- Pharr Riots' anniversary marks watershed moment in Valley history
- "This was the first demonstrable time in Rio Grande Valley history that a Mexican-American had successfully confronted the 'system' through the law courts and prevailed," Wallace said. "Shortly afterward, Pharr elected its first Mexican-American mayor.
- San Jose: Ex-cop accused of on-duty rape claims woman came on to him
- SAN JOSE -- They were alone for just three minutes, but that's all it took for then-San Jose police Officer Geoffrey Graves to suspect that a drunk woman who didn't speak much English and had just been involved in an emotionally draining fight with her ...
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Poor Law The Act Of 1601 Topics
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Police said Richard D. Matter II, 50, was riding his 1999 Kawasaki Vulcan south on state Route 147 in Upper Paxton Township when he struck the deer. Matter, who was wearing a helmet, was thrown from his motorcycle and landed in the roadway.
Millersburg man critical after hitting deer with motorcycle on state Route 147
Chris A. Courogen By
on September 15, 2010 at 7:01 AM, updated September 15, 2010 at 7:05 AM
on September 15, 2010 at 7:01 AM, updated September 15, 2010 at 7:05 AM
A Millersburg man is in critical condition at Penn State Milton S. Hershey Medical Center this morning after being flown there last evening by Life Lion helicopter after he struck a deer with his motorcycle, state police said.


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'Mad Men' Stoopball And Wicked Games
Here are links to and examples of items that I mentioned in my Friday column.
First up, my "Mad Men" Avatar. That's me in the turtleneck. Make yours here.
Oscar Insurgent Emerges
In a scenario reminiscent of "Avatar" a giant slept while an insurgent became the frontrunner for the best picture Oscar over the weekend.
The Iraq war themed film "The Hurt Locker" picked up two significant awards; Sunday it was named best film by the British Academy of Film and Television Arts - or BAFTA - besting the top grossing "Avatar."
Kathryn Bigelow was also named best director for "The Hurt Locker." »Read Full Blog Post
Waking Dream
I haven't been on vacation.
It just seems that way from the infrequency of postings.
But these are the dog days of summer and I've bitten by them. »Read Full Blog Post
Comic-Con Wrap-up
Yes I was gone last week. No I didn't go to Comic Con. In fact, I was at its opposite.
Instead of attending a convention dedicated to all things magical and sci-fi, or should I say SyFy, in San Diego, I was in Door Dounty, contemplating goats, fudge and sea gulls.
The two do have one thing in common - both are the place to be if you want to feel young. Even at my advanced age, it felt like I was the youngest person in the grandparent heavy DC. Meanwhile, the fan-based Comic Con is stuffed to the rafters with pop culture product that appeals to geeks of all ages. »Read Full Blog Post
Dueling Avatars
Does "Transformers: Revenge of the Fallen" cross "the uncanny boundary," that point where digitally portrayed images are accepted by the brain as real?
I'm thinking that not even the humans in the film about living fighting machines look alive.
The film received a mere 22% approval rating from the critics polled by Rotten Tomatoes, where the concensus was that it was noisy and lacked the human touch. Roger Ebert called it "a horrible experience of unbearable length." »Read Full Blog Post(3)


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The state has filed no legal challenges against any local comprehensive plan amendments since sweeping growth law changes passed the Legislature in 2011, according to the Department of Economic Opportunity.
Supporters of the 2011 law changes said they would return control of local growth management decisions to local government where it belonged.
This brief has been archived. The entire brief is available exclusively to LobbyTools subscribers.
Already a subscriber? Login, or call 850-915-0100 ext. 1 for customer support.


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Driver Accused Of Killing Woman In Mattapan Appears In CourtPolice say a man was drunk when he hit struck and killed a woman in a Mattapan crosswalk.
Victim Identified In Mattapan Fatal Hit-And-RunAuthorities have released the name of the woman who was struck and killed by a car Saturday night.
Dorchester Man Arrested In Fatal Mattapan Hit-And-RunA Dorchester man turned himself in early Sunday morning after police said he struck and killed a woman while driving drunk in Mattapan Saturday night.
At Mattapan Barbershop's 'Cut And Curls' Event, Kids Get Free Hair Cuts, School SuppliesFor the seventh year in a row, a Mattapan barbershop is offering free haircuts for kids grades 1-7.
Firefighter Hurt Battling Mattapan House FireAs hot as it was outside Sunday, it was a lot worse for firefighters battling a house fire in Mattapan.
Uncle: Boy Who Drowned At South Boston Day Camp Now 'Saving Lives'Family and friends gathered Thursday to say goodbye to a seven-year-old boy who drowned while attending a city-run day camp last week.
Child Found Barefoot, Alone At Mattapan Playground Reunited With FamilyBoston Police have reunited a young boy with his family nearly 24 hours after he was found wandering barefoot at a Mattapan playground.
Dashboard Camera Captures Pedestrian Being Hit By Minivan In MattapanBoston Police said they received no report from the incident, which a driver shared video of online.
Man Shot And Killed In MattapanA man has been shot and killed in the street in Boston's Mattapan neighborhood.
Overnight Shootings Leave 1 Dead, 3 Hurt In BostonThree shootings are under investigation.
Person Suffers Life-Threatening Injuries In Mattapan Double Shooting, Boston EMS SaysA person suffered life-threatening injuries in a double shooting late Saturday night in Mattapan, Boston EMS says.
Boston Elementary School Combating Trauma In KidsMattahunt Elementary School in Mattapan is combating trauma with a new innovative program.


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The Application of Molecular Diagnostic Studies Interrogating EGFR and KRAS Mutations to Stained Cytologic Smears of Lung Carcinoma
EGFR and KRAS mutation analyses are of increasing importance for guiding the treatment of non–small cell lung carcinomas. Insufficient cellularity of cell blocks can represent an impediment to the performance of these tests. We investigated the usefulness of cytologic direct smears as an alternative specimen source for mutation testing. Tumor cell–enriched areas from freshly prepared and archived rapid Romanowsky–stained direct smears in 33 cases of lung carcinoma were microdissected for DNA isolation and evaluated for EGFR and KRAS mutations. EGFR mutations were detected in 3 adenocarcinomas; 2 tumors had the L858R substitution and 1 an exon 19 deletion. KRAS mutations affecting codon 12, 13, or 61 were detected in 11 cases (8 adenocarcinomas and 3 non–small cell carcinomas). EGFR and KRAS mutations were mutually exclusive. Hence, archived and freshly prepared direct smears represent a robust and valuable specimen source for molecular studies, especially when cell blocks exhibit insufficient cellularity.
- Lung cancer
- Cytology
- Direct smear
- Fine-needle aspiration
- Non–small cell carcinoma
- Adenocarcinoma
Lung cancer is one of the most commonly diagnosed malignancies and represents the highest cause of cancer mortality in the world.1,2 Lung cancer is a histologically diverse disease dichotomized into 2 general categories: small cell carcinoma and non–small cell lung carcinoma (NSCLC). NSCLCs can be further subclassified into major subtypes, including adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and large cell neuroendocrine carcinoma.2
Adenocarcinoma represents the most common subtype of lung cancer.1 During the past decade, our understanding of the molecular pathogenesis of pulmonary adenocarcinoma has been improved and refined. This cancer is no longer regarded simply as a histologically diverse disease composed of distinct variants—such as bronchioloalveolar, papillary, and acinar—as recent studies have provided increased insight into the various molecular aberrations that underlie the pathogenesis of adenocarcinomas in different demographic groups. Two salient examples include mutations in the epidermal growth factor receptor (EGFR) gene, seen more commonly in East Asian women with a negative smoking history, and mutations in KRAS, observed more commonly in Caucasian male smokers.3
Approximately 10% to 15% of unselected NSCLCs have EGFR mutations, with the highest frequency occurring in adenocarcinoma.4,5 The most common EGFR mutations are small in-frame deletions in exon 19 and a point mutation in exon 21 resulting in an L858R substitution.6 These collectively account for approximately 90% of all EGFR mutations and phenotypically result in hyperactivation of the EGFR. Lung adenocarcinomas driven by these mutations are sensitive to EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib (Iressa) and erlotinib (Tarceva).7–9 Furthermore, when treated with these TKIs, patients who have tumors with EGFR mutations have longer progression-free survival than do patients with tumors without mutations.10,11
Oncogenic KRAS mutations are found in approximately 15% to 30% of NSCLCs.3,5 These point mutations most frequently involve codon 12 or 13; rarely, mutations occur at codon 61.12 They result in the impairment of the intrinsic GTPase activity of KRAS and are insensitive to GTPase-activating proteins, thereby leading to the accumulation of activated, GTP-bound KRAS protein. The occurrence of KRAS and EGFR mutations is mutually exclusive.13,14 Furthermore, as KRAS represents a downstream effector of EGFR, lung adenocarcinomas with mutations in KRAS are refractory to EGFR TKIs.15,16
The importance of identifying EGFR and KRAS mutations in lung cancer highlights an increasing emphasis on personalized medical care as molecular diagnostic testing to interrogate these mutations enables physicians to optimize therapeutic regimens. This is especially important for patients with lung cancer who have advanced-stage cancer at diagnosis and, as a result, are not candidates for surgical resection. In these patients, small biopsy specimens, often obtained by fine-needle aspiration (FNA) for cytologic examination, represent the only opportunity to obtain tissue material for diagnosis and ancillary molecular diagnostic studies. Consequently, there is increasing demand on cytopathologists to maximize the efficacy with which this limited tissue material is handled and analyzed.
Cell blocks prepared from lung and mediastinal lymph node fine-needle aspirates are routinely used for ancillary studies. Unfortunately, in some cases, insufficient cellularity of cell blocks represents an impediment to the performance of these studies, which can necessitate a repeated FNA during which the risks and complications are not negligible. There are limited reports in the literature demonstrating the usefulness of cytologic smears of lung cancer in the interrogation of EGFR mutations.17–19 These studies primarily used decoverslipped, archived smears as a source of DNA that was subjected to EGFR mutation testing via high-resolution melting analysis. We extended these findings by performing EGFR and KRAS mutation testing on fresh and archived direct smears via polymerase chain reaction (PCR)-based fragment analysis and direct sequencing–based tests. To validate this approach, we tested corresponding resection tissue or cytologic blocks in addition to the direct smears to correlate results.
Materials and Methods
Case Selection
The study was approved by the institutional review board at the University of Michigan, Ann Arbor. In 7 cases, air-dried, cytologic direct smears were prepared fresh from scraped tumor tissue from surgically resected lung masses and stained with rapid Romanowsky, without coverslipping. In 5 cases, air-dried, rapid Romanowsky–stained smears were prepared fresh from cytologic specimens, without coverslipping. For 21 cases, rapid Romanowsky–stained air-dried smears were obtained from the archive (1 smear per case). Coverslipped slides were incubated in xylene for 3 days, after which the coverslips were gently removed. Decoverslipped slides were then allowed to dry and were submitted for DNA isolation after the appropriate area containing tumor was selected (see "DNA Isolation"). The corresponding formalin-fixed, paraffin-embedded tissue block (7 cases) or cytology cell block (26 cases) was also retrieved in each case for comparison testing. The cellularity of the cell blocks was assessed by examining the H&E-stained sections and estimating the total number of tumor cells and their percentage of total cellularity (ie, percentage of tumor cells out of total cells including benign nucleated cells). The total number of tumor cells were semiquantitatively designated as follows: acellular, no tumor cells (score 0); sparsely cellular, fewer than 50 tumor cells (1+); moderately cellular, approximately 50 to 300 tumor cells (2+); and abundantly cellular, more than 300 tumor cells (3+).
DNA Isolation
All stained smears were reviewed by 2 cytopathologists (M.H.R. and S.M.K.), and the area containing the highest proportion of tumor cells was marked on the underside of each slide using a marking pen Image 1. Genomic DNA was extracted from the marked region (area range, 16–80 mm2) using the Pinpoint Slide DNA Isolation Kit (Zymo Research, Irvine, CA) according to the manufacturer's instructions and including the optional purification step. DNA was eluted in a final volume of 25 μL of TE buffer (10 mmol/L tris(hydroxymethyl)aminomethane-hydrochloride and 0.5 mmol/L EDTA; pH 9.0). Genomic DNA extraction from paraffin-embedded tissue and cytology cell blocks was performed on the BioRobot EZ1 (Qiagen, Valencia, CA) using the paraffin section protocol. For each block, 3 to 5 sections of 10-μm thickness were used for extraction. DNA was eluted in a final volume of 100 μL of TE buffer.
Mutation Testing
KRAS codons 12, 13, and 61 were evaluated for mutations using direct sequencing. Briefly, 2 fragments containing these codons were amplified using the following primer pairs: 5′-GTGTGACATGTTCTAATATAGTCA-3′ (forward) and 5′-GAATGGTCCTGCACCAGTAA-3′ (reverse) for codons 12 and 13 and 5′-GCACTGTAATAATCCAGACTG-3′ (forward) and 5′-CAATTTAAACCCACCTATAATGGT-3′ (reverse) for codon 61. Each 25-μL PCR reaction contained 5 μL of purified DNA, 500-nmol/L concentrations of each primer, and 1× Phusion HF mastermix (Finnzymes, Thermo Scientific, Vantaa, Finland). Cycling conditions consisted of denaturation at 98°C for 30 seconds followed by 40 amplification cycles: 99°C for 5 seconds, 60°C for 20 seconds, and 72°C for 20 seconds. An aliquot of each PCR product was confirmed by gel electrophoresis. The remainder was purified by using the QIAquick PCR purification kit (Qiagen) and subjected to bidirectional sequencing with ABI BigDye v1.1 terminators (Applied Biosystems, Carlsbad, CA) and the following nested sequencing primers: 5′-ATGTTCTAATATAGTCACATTTTC-3′ (forward) and 5′-GTCCTGCACCAGTAATATGC-3′ (reverse) for codons 12 and 13 and 5′-ATCCAGACTGTGTTTCTCCC-3′ (forward) and 5′-CCACCTATAATGGTGAATATC-3′ (reverse) for codon 61. Sequence products were purified using the DyeEx Spin Kit (Qiagen) and analyzed on the ABI 3130xl (Applied Biosystems). The forward and reverse sequence chromatograms were reviewed for mutations with software-assisted analysis (Mutation Surveyor, SoftGenetics, State College, PA).
EGFR mutations (exon 19 deletions and the exon 21 L858R substitution) were evaluated by using a PCR-based fragment analysis assay. Mutations were independently confirmed by direct sequencing using the following PCR primer pairs: 5′-TGGCACCATCTCACAATTGC-3′ (forward) and 5′-GAAAAGGTGGGCCTGAGGTT-3′ (reverse) for exon 19; and 5′-AGAGCTTCTTCCCATGATGATC-3′ (forward) and 5′-CAGCCTGGTCCCTGGTGTC-3′ (reverse) for exon 21. PCR conditions were as described for KRAS, except 300-nmol/L concentrations of each primer were used and the annealing temperature was 65°C. Amplification products were sequenced with the following nested sequencing primers: 5′-CCATCTCACAATTGCCAGTT-3′ (forward) and 5′-TGGGCCTGAGGTTCAGAG-3′ (reverse) for exon 19; and 5′-TCTTCCCATGATGATCTGTCC-3′ (forward) and 5′-GGTCCCTGGTGTCAGGAAA-3′ (reverse) for exon 21.
To determine if air-dried, rapid Romanowsky–stained cytologic smears represent a viable specimen source for DNA purification and mutational analysis, direct smears were first prepared with scraped tumor cells from 7 lung adenocarcinomas that were surgically resected Table 1 and Table 2 (cases 1–7). The smears were stained in rapid Romanowsky, and genomic DNA was extracted from tumor-enriched areas for EGFR and KRAS mutation testing. The extracted area ranged from 16 to 80 mm2, and the DNA yield averaged 1.02 μg (range, 0.2–2.82 μg). All cases exhibited robust PCR amplification in both mutation assays indicating that an adequate yield of high-quality DNA was extracted. The EGFR L858R substitution mutation was detected in 2 adenocarcinomas Figure 1. A KRAS G12D mutation was detected in another case Figure 2.
Next, for 26 cases, rapid Romanowsky–stained smears that were prepared from cytologic specimens were analyzed for EGFR and KRAS mutations. In 5 cases, the stained direct smears were prepared fresh and not coverslipped (Tables 1 and 2, cases 8–12). In the remaining 21 cases, archived stained direct smears were decoverslipped in xylene (Tables 1 and 2, cases 13–33). Areas enriched with tumor cells were microdissected for DNA purification in each case. The cytologic diagnoses for the 26 cases included the following: adenocarcinoma, 14; NSCLC, not otherwise specified, 10; squamous cell carcinoma, 1; and small cell carcinoma, 1. The extracted area ranged from 24 to 64 mm2, and DNA yield averaged 0.54 μg (range, 0.08–5.37 μg). Mutation analysis was successful in all cases. An EGFR exon 19 deletion was detected in 1 adenocarcinoma. KRAS mutations were detected in 7 cases of adenocarcinoma and 3 cases of NSCLC, not otherwise specified.
To validate the mutation results obtained from the stained smears, corresponding paraffin-embedded tissue blocks (cases 1–7) or cytologic cell blocks (cases 8–33) were obtained. Adequate tumor for mutation testing was present in each of the 7 tissue blocks. However, only 17 of 26 cell blocks contained sufficient cellularity; 9 cell blocks were completely acellular and, therefore, were not evaluated (Table 2). Overall, 23 of 24 cases demonstrated concordant EGFR and KRAS mutation results between the stained direct smear and the corresponding tissue or cell block. The discordant case (Table 2, case 28) was one in which concurrent KRAS codon 12 and 13 mutations were detected in the direct smear but not the corresponding cell block. Follow-up review indicated that the cell block contained sparse clusters of adenocarcinoma with an overall tumor cellularity of less than 10%. Consequently, the lack of detectable KRAS mutations in the cell block is likely a false-negative result due to lack of sufficient tumor cellularity in this specimen.
Overall, EGFR mutations were detected in 3 (14%) of 21 adenocarcinomas and not in the remainder of the cases examined. Of the 3 patients, 2 were men with a positive smoking history; the third patient was a woman with no smoking history Table 3. KRAS mutations were observed in 8 (38%) of 21 adenocarcinomas and 3 (30%) of 10 NSCLCs, not otherwise specified. All 11 patients with tumors with KRAS mutations had a positive smoking history. Finally, EGFR and KRAS mutations were mutually exclusive.
The advent of targeted therapeutics is changing the approach to management of patients with pulmonary adenocarcinoma. Fundamental to this was the discovery that EGFR mutations predict response and survival benefit in patients treated with EGFR-targeted therapies.10,11,15,20 KRAS mutation status has also gained relevance since lung tumors with these mutations are resistant to EGFR-targeted therapy.15,21 As the number of patients who receive targeted therapies increases, so too does the need to interrogate the mutation status of the associated molecular markers on small biopsy specimens of primary and metastatic pulmonary tumors. The possible inadequacy of specimens to perform these studies is problematic; additional biopsy procedures are not without risks and lead to delays in treatment.
To date, few studies have examined the use of immediately acquired or archived direct smears from FNA material for use in molecular analysis. The use of direct smears for molecular studies provides numerous possible advantages over the use of cell blocks, including the ability to ascertain at the time of the procedure whether sufficient material is available for subsequent analysis; less processing, resulting in decreased turnaround time and technical-related expenses; tumor cell enrichment enabling DNA isolation from cellular material obtained from a single pass as opposed to a cumulative mixture of cellular material from multiple passes; and obtaining high-quality non–cross-linked DNA owing to absence of exposure to formalin. The use of direct smears also provides advantages over some other suggested methods such as dividing a specimen into aliquots in a microcentrifuge tube22,23 or applying an aliquot to a filter paper card.24 In contrast with the latter 2 methods, the use of stained smears for molecular testing provides the opportunity for pathologist-based review of tumor cell adequacy before extraction.
This activity is advocated by many researchers and clinicians in the molecular pathology testing community. For example, in the most recent College of American Pathologists survey, 121 of 130 laboratories performing KRAS mutation testing require pathologist review of the specimen before testing.25 This is an especially important quality assurance step given the limited sensitivity of some molecular tests. It also provides the opportunity for tumor cell enrichment by microdissection in cases with limited tumor cellularity. Given these advantages and the chief drawback of cell blocks (ie, the lack of sufficient material in a significant number of cases), the specific goals in this study were as follows: (1) investigate the potential for developing a real-time method whereby direct smears obtained during FNAs are effectively triaged by pathologists for subsequent EGFR and KRAS mutation testing, (2) demonstrate and ensure that such material obtained during the procedure would prove to be adequate and reliable for subsequent molecular analysis, and (3) ascertain whether mutational analysis could be performed retrospectively using archival cases.
In our study, the use of cytologic direct smears for molecular testing proved to be a robust and reliable method. Mutation testing was successful in freshly obtained and archived rapid Romanowsky–stained smears and yielded results that were concordant with those obtained from corresponding tissue blocks and cell blocks. Of note is that we had 1 discordant case in which KRAS mutations were identified in the direct smear but not in the corresponding cell block owing to limited tumor cellularity. This case highlights a potential limitation of cell blocks that may contain tumor cell clusters that are not evenly dispersed throughout the block, thereby limiting the ability to enrich for tumors. The cell block in this case contained sparse tumor cell clusters with an overall tumor cell percentage of less than 10%. This proportion of tumor cells is below what is required for the direct sequencing assay we used for KRAS mutation testing, likely leading to the false-negative result. In contrast, the area selected and extracted on the direct smear contained 80% tumor cells, which allowed detection of the mutation in this case. Also of significance is that a large percentage of cell blocks in our study were acellular (9/26 [35%]) and, thus, proved inadequate for molecular testing. Direct smears were successfully tested in each of these cases, underscoring the usefulness of these preparations in cases in which cell blocks contain inadequate cellularity.
Because the procedure of removing coverslips is time-consuming, it is more convenient for pathologists to anticipate that additional cellular material will be needed for molecular analysis and to maintain at least 1 uncoverslipped stained slide at the time of the FNA procedure that can be immediately sent for EGFR and/or KRAS testing. Nevertheless, it is helpful to know that coverslipping and subsequently decoverslipping the smears does not compromise the quality of DNA that is isolated for molecular studies. Hence, if molecular studies are required retrospectively after the cytologic diagnosis is made, coverslipped smears can be effectively used in a scenario in which the cell block exhibits insufficient cellularity.
A related key finding in our study is that rapid Romanowsky–stained slides can provide high-quality DNA, even if archived for a prolonged period. Specifically, in our study, we were able to isolate high-quality DNA from smears that were up to 5 years old. A recent study by Killian and coworkers26 reached the same conclusion by demonstrating that DNA obtained from rapid Romanowsky–stained direct smears may be used successfully in high-resolution comparative genomic hybridization arrays, DNA methylation assays, and single nucleotide polymorphism genotyping platforms. These findings are noteworthy in that, for these analyses, high-quality, high-molecular-weight DNA was required. Their study revealed that DNA is stable in the oldest tested specimens (ie, 10 years old) and that Papanicolaoustained slides surprisingly yielded DNA of reduced quality. They postulated that hematoxylin, which is included in the Papanicolaou stain, could lead to DNA degradation in these specimens, which correlates with findings in previous studies.27 These findings, in conjunction with our results, are serendipitous in that rapid Romanowsky–stained slides are optimal for immediate on-site triaging at the time of the FNA procedure. This staining method is inexpensive and rapid and allows for easy visualization of tumor cells to be extracted. Furthermore, tumor-enriched areas can be easily identified and marked before triaging for molecular studies.
The ability to visualize and pathologically vet material marked for subsequent molecular analysis is also an important feature in the present study that warrants further emphasis. In the recent study by da Cunha Santos and coworkers,24 archived material stored on Whatman filter papers (FTA cards), although sufficient for providing high-quality DNA, did not always show the same molecular mutational profile as material harvested from corresponding cell blocks in the same FNA specimens. The authors pointed out that different tumor areas may demonstrate distinct molecular profiles (ie, tumor heterogeneity), and this offers an explanation for discordant findings between cell blocks and Whatman FTA samples because they were obtained from different passes from the same specimens. However, another possibility is that tumor cells were not well-represented in cellular material stored on the Whatman FTA cards from discordant samples; rather, these samples may have predominantly contained contaminating benign cells such as inflammatory cells, bronchial epithelial cells, or histiocytes.
In the present study, these variables were controlled because the presence and proportion of tumor cells were verified on the direct smear before extraction. The area on the smear that is selected for DNA extraction ideally contains a large number and high representation of tumor cells (>40%). However, the minimum required proportion of tumor cells will depend on the analytic sensitivity of the specific mutation assay used by the testing laboratory and could range from about 1% to 40%. By using our PCR-based fragment analysis and direct sequencing–based tests, we were able to detect an EGFR mutation in a case with 15% tumor cells (Table 1, case 10) and a KRAS mutation in a case with 5% tumor cells (Table 1, case 23). Rapid Romanowsky–stained direct smears provide a feasible, robust source of DNA for use in EGFR and KRAS mutation analyses. Given the ability to immediately triage material and ensure adequacy for molecular ancillary studies, this method potentially represents an improved paradigm in acquiring and archiving FNA material for these studies.
- © American Society for Clinical Pathology


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realmagick.com The shrine of knowledge.
Europa Moon Subsurface Ocean
A selection of articles related to europa moon subsurface ocean.
Original articles from our library related to the Europa Moon Subsurface Ocean. See Table of Contents for further available material (downloadable resources) on Europa Moon Subsurface Ocean.
- What are the names for the thirteen moons of the year?
- There are thirteen Lunar months in the year, the Full Moon is near the mid point of the Lunar Month. The Lunar Moons listed here may not always occur as given because the first New Moon of a new Lunar Year may not coincide with the first day of the first...
Religions >> Paganism & Wicca
- So What is a Blue Moon?
- We are not having any Blue Moons this year but the experts say that year 2001 will have an official "Blue Moon" in November. Your geographic location can make a difference to your experience of a Blue Moon. Depending on your longitude you may go...
Astrology >> The Moon
- Moon Gardening
- There is nothing more beautiful at night than looking up at the Moon and looking down at its audience. A symphony of beautiful flowers that stand at attention, when the night comes upon us! Whether you would like an Herb Garden, a Medicine Wheel Garden, or...
Earth Mysteries >> Herbalism
- Howling at the Moon!
- Lunacy, says it all. We all know that the time of the full moon feels strange. Legend has it that the full moon brings out the worst in people: more violence, suicides, accidents, and aggression. The influence of the moon and behavior has been called "The...
Astrology >> The Moon
- Phases of the Moon: 1941 to 1950 - Dates and Times
- Year New Moon First Quarter Full Moon Last Quarter Delta T 1941 Jan 5 13:39 Jan 13 11:05 Jan 20 10:02 00h00m Jan 27 11:04 Feb 4 11:41 Feb 12 00:27 Feb 18 18:08 Feb 26 03:03 Mar 6 07:42 Mar 13 11:48 p Mar 20 02:52 Mar 27 20:15 A Apr 5 00:12 Apr 11 21:15 Apr 18...
Astrology >> The Moon
- Phases of the Moon: 1931 to 1940 - Dates and Times
- Year New Moon First Quarter Full Moon Last Quarter Delta T 1931 Jan 4 13:15 Jan 11 05:10 00h00m Jan 18 18:36 Jan 27 00:05 Feb 3 00:26 Feb 9 16:10 Feb 17 13:11 Feb 25 16:41 Mar 4 10:36 Mar 11 05:15 Mar 19 07:51 Mar 27 05:03 Apr 2 20:05 t Apr 9 20:16 Apr 18 01:0...
Astrology >> The Moon
- Phases of the Moon: 1921 to 1930 - Dates and Times
- Year New Moon First Quarter Full Moon Last Quarter Delta T 1921 Jan 1 04:35 00h00m Jan 9 05:26 Jan 17 06:30 Jan 23 23:07 Jan 30 20:02 Feb 8 00:36 Feb 15 18:52 Feb 22 09:32 Mar 1 14:02 Mar 9 18:09 Mar 17 03:48 Mar 23 20:18 Mar 31 09:13 Apr 8 09:06 A Apr 15 10:1...
Astrology >> The Moon
Europa Moon Subsurface Ocean is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Europa Moon Subsurface Ocean books and related discussion.
Suggested News Resources
- Observing Galilean's moons orbiting Jupiter
- Meanwhile, missions to some of Jupiter's moons, primarily Europa which almost certainly possesses a subsurface ocean of liquid water and thus possibly some form of life, are presently being designed and may travel there during the next decade.
- Pluto's largest moon, Charon, likely was fractured as subsurface ocean froze
- WASHINGTON – Images from the New Horizon space probe suggest that Pluto's moon Charon once had a subsurface ocean that has since frozen and expanded, causing the surface to stretch and fracture, NASA said Friday.
- NASA's foremost solar system explorer says Europa lander a "necessity"
- Bolden has said NASA should fully explore Europa with a flyby mission before building and flying a lander to Jupiter's ice-covered moon, which contains a vast, subsurface ocean.
- Lost City of the Atlantic --"The Birthplace of DNA and Earth's First Living
- Scientists are interested in understanding early life on Earth because if we ever hope to find life on other worlds - especially icy worlds with subsurface oceans such as Jupiter's moon Europa and Saturn's Enceladus - we need to know what chemical ...
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
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Guarantee + WarrantyBacked by our 30 Day Electronics Performance Satisfaction Guarantee AND our 6 Month Manufacturer's Warranty Against Material Defects.
Balcony Gard
Covers up to 900 Square Feet
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Get rid of birds silently. This low-profile electronic bird repellent device uses silent-to-humans, ultrasonic sound waves to repel annoying birds from small outdoor areas around the home.
The Balcony Gard helps protect your patio, deck, and balcony from pest bird infestation. This simple-to-install ultrasonic bird deterrent is motion-activated, and mounts nearly anywhere!
Item # BG
- Ultrasonic bird deterrent – emits silent-to-human frequencies that deter birds
- Motion-activated – built-in motion sensor activates when birds move into 900 sq. ft. coverage area
- Continuous protection – repels birds with 24/7 easy-to-use volume control
- Fully programmable – uses state-of-the-art technology to create powerful high and low frequency ultrasonic waves
- Weather-resistant – casing is designed to withstand outdoor use (rain cover included)
- Dual power modes – AC or batteries
Built especially for small outdoor areas. Effective coverage up to 900 sq. ft. per unit.
|Effectively Repels:
|Ideal For Use At:
Ultrasonic sound waves do not mimic natural animal sounds like sonic repellent devices do, so it is not targeted to specific pest types. Instead, ultrasonic sound waves (which are above the human hearing range, thus silent-to-humans) annoy and irritate pest animals into leaving, and are effective against many birds and small pests.
If you have very small birds such as sparrows, it is recommended the device is set to constant instead of motion-activated (there is a control switch to change this setting). Larger birds such as pigeons are more likely to set off the motion-activated sensor.
- Keep outdoor spaces clear of annoying birds
- Protect cars, property, and landscaping from corrosive bird dropping damage
- Protect home-grown fruits and vegetables from birds and small pests
- Reduce health risks and liability risks associated with pest infestation
- Maintain property aesthetics
- Decrease nuisance for residents and neighbors
For maximum, sustained success in your bird control efforts, a synergistic approach is recommended. Synergy is the interaction of two or more forces producing a combined effect that is greater than the sum of their individual effects. We often recommend companion products – combining sonic repellent devices with visual scares or scent and taste aversions. This kind of multi-sensory attack is extremely effective in deterring pest birds from an area permanently.
Companion Products:
Bird Spikes Kits Scare Eyes Bird Stop
Replacement Parts:
- Unit dimensions: 6.75" x 5.5" x 3.5"
- Box dimensions: 10" x 8" x 4" / Shipping weight: 3 lbs
- AC Power Cord Length: 30 ft. (all versions)
- Coverage: Up to 900 sq. ft. in a generally oval pattern
- Frequency Range: 15–25 kHz (adjustable)
- Sound Pressure: 90 db at 1 meter
- Electricity Costs: Less than $0.25/month
- Motion sensor range: 35' x 70'
- Working current: <200 mA
- Power supply: 4 x 1.5v "C" batteries or included 120v AC adaptor. Other voltage adaptors should be purchased locally. Unit switches to battery power during a power failure (if batteries are in).
- Compliance: UL Listed and CE Marked
Please note 240v adapter option – UK style pins only. Unit will work with locally sourced 12v/240v adapters. Please contact customer service for other options


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Acetaminophen is toxic viagra side effects tinnitus to the liver only in excessive doses or when the protective-detoxifying pathway in the liver is overwhelmed. Alcohol and acetaminophen. Accumulation of the toxic metabolite N-acetyl-p-benzoquinone-imine (NAPQI) is responsible for the death of hepatocytes. Acetaminophen is the second most common cause of death from poisoning in the United States.
6. How is acetaminophen toxic to the liver?.
These results were obtained using an in vivo perfusion method to examine surgically 'isolated' segments of small bowel viagra side effects tinnitus. Inasmuch as glucose absorption was greater in the ileum of infected rats (Table 12.2), Symons hypothesized that the failure to observe malabsorption when the entire intestine was taken into consideration despite jejunal defects, was because of an ileal compensatory absorptive mechanism (Symons, 1960). In the latter experiment, a carbon 11-labelled Chlorella protein was used as a marker in the dietary protein that comprized 8–20% of the administered meal. Glucose uptake by jejunum was significantly reduced compared with that in jejunum from uninfected hosts , further examination of data on glucose absorption indicates that during the intestinal phase of nippostrongylosis.
In other studies employing the Cori method (Wilson, 1961) to test the glucose absorptive capacity of the entire small intestine, the rate of glucose uptake was judged similar in infected and uninfected hosts (Symons, 1960b). Host Parameter 1 hra 15hrb Jejunumc (mM hr−1g−1 dry wt mucosa) Ileumd (mM hr−1g−1 dry wt mucosa) Entire small intestinec (mg/40 min) a Uninfected Infected % of protein meal digested and absorbed 20 31.1 68.8 (n=17) 57.4 (n=16) Glucose a absorbed 4.92±0.51 (n=12) 0.88±0.27 (n=12) 1.2±1.30 (n=6) 3.67±1.26 (n=2) 201±12 (n=8) 200±20 (n=11) Symons (1961a) Symons and Jones (1969) c Symons (1957b) d Symons (1961) b delivered by stomach tube (Symons, 1959a). Infection had no significant influence on the percentage of the test meal digested and absorbed , in analogous studies in which protein assimilation was measured 17 h after gastric intubation.
More than skin deep viagra side effects tinnitus. 31. Women's Dermatology. New insight on the viagra side effects tinnitus etiology and treatment of cellulite according to Chinese medicine. Am J Acupunct 1996.
Nova Iorque.
M., Van viagra side effects tinnitus Deerlin, V. (2002). L., Clark, C.
M., & Grossman, M. Neuropsychology, 14(4), 210–286. Memory encoding and retrieval in frontotemporal dementia and Alzheimer's disease.
Lemasters JJ, viagra side effects tinnitus trost LC. Am J Physiol 1998. Shared pathways to necrosis and apoptosis viagra side effects tinnitus. Necrapoptosis and the mitochondrial permeability transition.
Thus, the diagnosis has to be established by additional viagra side effects tinnitus laboratory tests. Chromogenic assays are also commercially available. Although a prolonged bleeding time is the hallmark of von Willebrand viagra side effects tinnitus disease, this laboratory finding is not specific. Quantitative assays depend on factor XIII transamidase properties (i.e., the incorporation of monodansylcadaverine into casein). These usually include measurements of the amount of von Willebrand antigen present in the plasma, the functional activity of the VWF, and the procoagulant activity of the associated factor VIII molecule.


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My instructor didn't make a big deal about not hitting the pedal C either... he said don't worry about it ad it will come around in time.
I don't know this for a fact ... just my take on pedals. If you practice playing lower than the F# then the F# becomes less drastic and not the end of the instruments range. Sort of the opposite of Adam Rapa's "today's squeek becomes tomorrows note"
I do agree some trumpets are easier to play the pedal C on then others. My Bach isn't and since it's my main ax ... it's the one that counts .. well to me it counts.
Someone has to know how to rip a pedal C on this site


text: Financial Services Build Loyalty With Face-to-Face Video Banking The world of finance lives and breathes online. In order to invest, borrow and manage their portfolios, clients expect their financial services firm to be accessible, providing immediate expert consultations and a seamless way to make decisions and manage wealth. The financial industry is adopting the platform to deliver video-enabled services that cultivate stronger, longer lasting relationships with clients. Start Your Free Trial Request a Demo Hear How a Leading Banking Customer is Video-Enabling Customer Engagement NCR Taps Vidyo for Secure, Seamless Video Integration Vidyo Enabled Customer Engagement Credit Union Case Study: BluCurrent Credit Union's Video Banking Agents Provide Personalized, Efficient Member Service Learn how BluCurrent Credit Union, which operates primarily through its three physical branches, provides efficient, expert and personal banking services to all of its members, regardless of the branch that they frequent. The solution revolved around using a Vidyo solution in each of the physical branches, with services conducted through a centralized operations center. View Now Video Banking White Paper Video Banking: The next chapter in a bank's digital transformation Download this free White Paper and get: The benefits of Video Banking Insights and learnings from banks who are already offering video banking The steps to follow and the challenges to overcome to successfully implement a video banking service All the results from our survey of 136 bankers from 52 countries Download Now FinServ CIO Special Research: 2016 CIO Agenda — A Financial Services Perspective Download this Gartner report and get: A rich look at the maturity and evolution of digital business in Gartner's FS CIO client base Insights into how FI CIOs are planning for the future A deep look at the business and technical drivers and inhibitors FI CIOs are experiencing View Now Video Enabled Financial Services High-touch Customer Service with Embedded Video Communication The VidyoWorksTM software platform video-enables your high-value client services and is easily integrated with your financial services infrastructure, applications and workflows. Natural, interactive HD video meetings can be conducted securely over the Internet and 3G/4G/LTE mobile networks. Subtle facial expressions and gestures that enhance understanding are part of the interaction, not lost in transmission. One-click access to secure, HD video consultations with a personal banker from your existing customer web portal or mobile app. The power to include subject matter experts and resources at any point during a video meeting. A convenient way to see and review portfolio account summaries and reports while meeting together online. Video Enabled Insurance Claim Processing DEKRA Accelerates Claims Management Netherlands-based DEKRA Experts B.V. counts on VidyoConferencing™ solutions to resolve insurance claims with speed and efficiency. Claims adjusters video conference with customers in the field, which allows them to visually evaluate damages and settle cases in days instead of weeks or months. DEKRA found the video-enabled service to be more personal than the phone and more efficient than sending claims representatives into the field. "We have doubled the number of damage assessments we can perform on a daily basis, and we are now able to serve more people across our 8,000 mile territory." Face-to-Face Online Banking IndusInd Bank Selects Vidyo for Video Banking IndusInd Bank, one of the fastest growing new-generation private sector banks in India, selected VidyoWorksTM to power a mobile and desktop-based banking service. Video Branch is a free service that enables a face-to-face video banking with a branch manager, relationship manager or with a centralized executive. "Our Video Branch 'face-to-face' online banking customer service, powered by Vidyo, is the next frontier of banking and brings our branch managers and centralized banking services closer to our customers with highly personal interaction. VidyoWorksTM is the only solution that could deliver on the promise of high quality connectivity from any location, on any device over any network and we are pleased to offer this very high-quality, easy to use service to our customers." Romesh Sobti, Managing Director and CEO, IndusInd Bank Read the News Release Video Conferencing for Financial Services Solution Brief: Video Communication for Portfolio Management, Mortgage Lending and Banking Learn how to host secure face-to-face video interactions with high-value clients when their busy schedules and conflicting priorities make travel impossible. HD video conferencing offers immediacy and clarity, and with a level of trust that nothing else can match when in-person meetings are not an option. Download Solution Brief


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Carly White
Latest posts by Carly White (see all)
- "Natasha, Pierre & The Great Comet of 1812" Begins - October 23, 2016
- Irving Berlin's "Holiday Inn" Opens at Studio 54 - October 15, 2016
- "Waitress" All-Female Creative Team Earns Strong Reviews - May 1, 2016
- "Long Day's Journey Into Night" Begins Previews - April 10, 2016
- Critics Love "Eclipsed," But Box Office is Slow to Respond - March 17, 2016


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Oak Brook Bath and Tennis Private Events
Let our Bath and Tennis Clubhouse be the backdrop for your special day. With its 35-foot vaulted ceiling, stone double-sided fireplace, natural wood and floor-to-ceiling windows, the Clubhouse offers a spectacular view of lush wooded acres and a serene lake with a fountain. View the Bath and Tennis Club directions and the Clubhouse diagram.
The Clubhouse is perfect for any gathering that calls for a special and private setting from outdoor weddings and wedding receptions to intimate baby showers. Catering preparation can be left to one of our preferred caterers who are familiar with our set-up and offer a wide variety of menu selections, allowing you to enjoy hosting your event. Contact our Private & Corporate Events Department for available dates, monthly specials or a facility tour - Tammy Perri at firstname.lastname@example.com or (630) 368-6442.
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Boomer Esiason: Don't Worry About Stephen GostkowskiBoomer Esiason joined Toucher & Rich on Monday to discuss their 27-16 win over the Steelers, including the struggles of Stephen Gostkowski and their bend-don-t-break defense.
Ainge: Celtics Will Be Careful With Smart's Ankle Injury; Olynyk Not Expected Until Mid-NovemberDanny Ainge joined Toucher & Rich on Thursday to discuss a few injuries the team is dealing with, as well as his fancy new card that gets him free Chipotle.
Brandon Meriweather Talks Dirty Hits, Unfair Rules Against Defensive Backs On Toucher & RichFormer Patriots safety Brandon Meriweather joined Toucher & Rich on Wednesday to discuss dirty hits in the NFL.
Howe: Temper Expectations For Dion Lewis Upon Eventual Return To Patriots"I think you've got to be reserved with your expectations for Lewis this season. I believed that before we even found out about the second surgery, just because a torn ACL in November is really difficult -- unless you're Adrian Peterson -- to come back from and be successful the following season."
Matthew Slater: No Place In Football For Dirty PlaysPatriots special teams captain Matthew Slater joined Toucher & Rich on Tuesday to discuss the team's win over the Bengals, and some dirty hits that were thrown their way.
Boomer: Patriots Are Alone Atop A 'Murky' AFCThe Patriots are the best team in the AFC, but after that, Boomer Esiason said the conference gets a bit "murky."
Is Dion Lewis Worth Stashing On Your Fantasy RosterSome fantasy football owners are scouring the waiver wires for players worthy of a roster spot despite the fact they're not currently playing. CBS' Dave Richard says Dion Lewis is worth stashing if you have the space.
Mike Pereira Describes Roger Goodell's Aggressive Shove, Advocates For 'No Fun League'"This whole thing that happened with the shove happened even before he became commissioner, when he was the No. 2 guy. It's just born out of stubbornness and frustration."
Meriweather On Toucher & Rich: Bill Belichick Doesn't Pull Punches With AnyoneThe Big Bang Clock is back on Toucher & Rich.
Toucher & Rich: Fan Loses His Mind After Red Sox Season EndsMonday night was a tough one for Red Sox fans, leading to some waterworks (and pure rage) after Boston was swept out of the playoffs.
Boomer Esiason: 'Never Thought Brady Would Look That Good' In ReturnBoomer Esiason joined Toucher & Rich for his weekly call into the show, breaking down Tom Brady's return and the Gronkowski-Bennett dynamic.
Is This The Week Rob Gronkowski Breaks Out For Patriots -- And Fantasy Owners?With Tom Brady back and a very favorable matchup against the Cleveland Browns, is this the week Rob Gronkowski breaks out for the Patriots -- and fantasy football owners?


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Diamond Rio 600
Based on 8 reviews
- Good 4
- Average 4
- Bad 0
Users Score Review This
- Good 5
- Average 5
- Bad 3
Diamond Rio 600 User ReviewsPC
Rio 600 32MB + 32MB backpackThe good:
As previouslySummary:
As a follow up to my previous review I can now let people know that it is possible to downgrade the firmware on the Rio 600 from 1.56 down to 1.15 from within iTunes to ceate the single 64MB storage device from the 32MB + 32MB memory components.
Rio600+32MB backpackThe good:
Excellent sound quality when used with good earphones. Upgrades and support welcome. Excellent display and onboard software. Fully iTunes compatible.The bad:
Ver slight background buzz after switch on (but not noticed during playback).Summary:
I recently obtained the Rio600+32MB backpack at an absolute steal of a price (£25, ~$37) on sale at the 'Scottish Power' closing down sale. The Rio itself came with version 1.07 firmware. I plugged the Rio into my iMac via the USB lead and it was immediately recognised by iTunes in Mac OS 9.2.1 or Mac OS X 10.0.4 as an external device without any software installation. I connected the backpack and upgraded the firmware to version 1.15. The Rio600 showed up as a single device with 64MB memory (seen as one 64MB internal and 0MB external memory) but the installed demo tunes were wiped (not a g...
Great player except for the expensive backpacks!The good:
I have no gripes about the player at all. I've had mine 6 mos and love it!The bad:
Upgrading the memory is incredibly expensive and bulky! The 32mb "backpack" (which does include rechargeable battery) runs about $79.00, with the 64mb @ $119.00.Summary:
I love this player except for the backpack situation. If this unit used flash/smart/mmc etc. I would say it is the best buy around. I still think it's great, but be ready to pay some big bucks if you want an extensive music library with you and have some place to store the goofy backpack (be careful-the prongs on the battery hook-up bend easily causing the unit to not work!).
Cooperative monkeyThe good:
It plays musicThe bad:
The product is just poor compaired to mindiscSummary:
OK....This product was advertised glamourously (how it should be) but I feel as if I have fell into this trap. I got to emphasise that the soft layer of smoothing over the Rio600 is blatantly taky! I have used it day on day out but the thin back material layer just flakes off, I am very dissappionted with this. Also the software, I dished out £150 + postage fees to receive this product and to find that you have to register RioSoftware for $20 (about £12-15) this just made the product a ripoff for people who dunno much about GOOD mp3 players. So I say GET SONY MINIDISC!!!! A WHOLE LOT BETTER...
where did it all go wrong?The good:
great sound, when it works!The bad:
poorly made, bad quality, bot durable, brakes easily wears and chips through regular useSummary:
I bought a rio 600 and was extremeley happy with it for the first week or so, i mean who wouldn't be? it had great innovative features such as customisable eq settings and a phat blue back light. I was also very pleased with the fact that it supported WMA format as i feel this to producr much better quality sound then mp3 does, it also enabled me to fit a whole album (instead of just 30 minutes which mp3 allows) of music on to just 32mb of memory. On the surface the Rio 600 appeared to me to be the obvious choice, but the problems occured when a fualt devoloped in the player and the sound ...
Rio600The good:
The good stuff about the Rio600 is the Outstanding LCD display. I also like the unique shape of the Rio600, with it's special curve for the hand. Another thing that impressed me is how you can change the skins on the Rio600 for your comfort of design.The bad:
The bad stuff is probably the memory it holds, 32mb.
Now the Rio500 holds 64mb.
But then again you can add more memory to the Rio600, like the Rio500.
Overall I think it's a great Mp3 player. I give it a 4 out of 5 because of the memory it holds, but on all other qualities of it its a great mp3 player. Het I am getting on this Christmas, it sounds great!


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Howl's Moving Castle
- Directed by Hayao Miyazaki
Howl's Moving Castle review
Howl's Moving Castle
Based on the novel by Diana Wynne Jones, Howl's Moving Castle is a complex fantasy/love story. Set in the world of Ingary, where magic and sorcery are commonplace, the film begins with Sophie. Plainer and less flamboyant than her mother and younger sister, she seems fated to spend her life running her father's hatshop. That is until Howl steps onto the scene. Howl is a notorious wizard, famous for devouring the hearts of young girls. When he rescues Sophie from the unwanted attentions of two soldiers, they end up running from demons which are after Howl. Believing they have given them the slip, Howl leaves Sophie to make her own way home. However, the sender of the demons, the Wicked Witch of the Waste, soon finds Sophie, and, in a fit of jealously over Howl's attentions, curses her into the body of a ninety year old woman. Unable to talk about the curse, Sophie leaves home, eventually ending up in Howl's moving castle, as his cleaner and general housekeeper.
Sophie is a fascinating character. Believing herself to be unattractive, as many people might consider her to be beside her blonde and beautiful mother and sister, she's very shy. However, in her old body, she seems to gain confidence, perhaps because she knows that she is no longer being judged on her looks. She alternatively both bullies and mothers Calcifer, Maikl and Howl into doing what she wants them to do. Don't be mistaken - it's for their own good.
Calcifer is the fire demon whose power is behind Howl's moving Castle. Voiced by Billy Crystal, he's welcome comic relief. He's almost the equivalent of Robin William's Genie (from Alladin) in terms of comedy and drama. He also appears to be bound to Howl, although he begs Sophie to find a way to break it. Unfortunately, both Howl and Calcifer are bound to silence by the nature of the curse, meaning Sophie has to first figure out what the curse actually is.
Maikl is a young boy in Howl's service. He refers to Sophie as 'Granny' or 'Grandma' and the two grow close over the course of the film. He's an endearing character.
Howl is a vain man, although it must be admitted that he has just cause to be. He's beautiful, in an almost feminine way (this is an anime). Such a pity he's just a drawing. Even his voice is sexy. Anyway, moving on, Howl is also shown to be childish, in many ways, and cowardly at times.
The other characters, include the Wicked Witch of the Waste's, a character who slowly goes from both impressive and scary to slightly pathetic, Madam Suliman, a powerful sorceress, and, among others, Turnip-Head, a mysterious scare-crow who appears to be attached to Sophie.
Although the film is quite long, at just over two hours, I was never bored (and I have a very short attention span). I actually watched the film twice in two days, something almost unheard of. The plot is interesting, although it could have done with a tad more explanation at times, and, as you've probably guessed, the characters are well rounded and endearing (although not all likable). The plot is sweet and romantic (it could almost be described as girly), and the animation is breathtaking.
All in all, great film. I just hope they plan on making the sequel.
Howl's Moving Castle Forum Posts
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- Cocoon (1985) & Cocoon: The Return (1988) [1]
- A Good Marriage (2014) [3]
- Film Club - Week 60 - Movie Selection [18]
- Open Grave (2013) [2]


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why cant a man see the good in front of them and just throw it away?
My daughters father left me for another woman, actually girl, we were together 2 years our 1st baby, and he said he was tired of me just like that and that he didnt want me anymore. When i asked why he said we argue too much and you dont want to have sex as much as i do. He told me not to fall in love with him but after 2 years and a baby what do you think is gonna happen obviously he didnt cause he found another woman 1 week after we broke up and showed me the hickeys on him and said i didnt care about you the whole 2 year s we were together. that really hurt me and then to top it off brought the girl to the club where i went and rubbed it in my face when i specifically asked him not to. IM still hurt its been a month already.


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Event Details
Date(s) & Time(s)::
July 30, 2016 at 10:00 AM until 5:00 PM
Location: Black Pine Animal Sanctuary, 1426 W. 300 N., Albion
Phone: (260) 636-7383
Link: http://www.blackpine.org
Event Description
Saturday, July 30, 2016
10:00 a.m. to 5:00 p.m.
Summer Fest has been an annual tradition at Black Pine for more than 18 years! The last Saturday in July each summer we celebrate our hard-working volunteers, dedicated student interns, and our supporters by coming together with a fun-filled day of special activities. This is a great day for first-time visitors to come meet the animals, their caregivers, and learn more about Black Pine's mission! Bring a picnic or enjoy concessions for sale during this event only. Enjoy the day with us!
No guided tours are scheduled, instead visitors can enjoy exploring the sanctuary throughout the day and meeting our keepers stationed all around the compound to introduce you to the animals, answer your questions, all while doing outreach presentations and providing enrichment to the animals. No appointments necessary!
Regular sanctuary tour rates apply. (Free for Park Pal members!)
What are your thoughts CLICK HERE to leave us a "QUESTION OF THE DAY" comment.
© Copyright 2016, A Quincy Media broadcasting station. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
The July 2014 episode of "Murfreesboro Storytellers," a 30-minute interview program hosted by John Hood, is slated to begin airing Monday, July 7, at 7:30 p.m. on CityTV. The July episode features new Murfreesboro Mayor Shane McFarland.
McFarland, who turns 40 in August, is a small business owner who graduated from MTSU in 1997 with a degree in accounting. McFarland won election in April to a 4-year term to serve as Murfreesboro Mayor. The July program, recorded in the Murfreesboro City Council chambers in City Hall on 111 W. Vine St. in Murfreesboro, Tenn., is produced by CityTV's Michael Nevills.
The interview features a discussion with Murfreesboro's Mayor on the following topics:
• Road projects, including the interchange at Broad and Memorial Boulevard.
• The planned indoor tennis complex at Old Fort Park slated to open in early 2015.
• Construction of the bridge on Joe B. Jackson Parkway.
• A planned new Murfreesboro Police Headquarters on Highland Avenue scheduled for completion in 2017.
You can watch "Murfreesboro Storytellers" on CityTV (located on Comcast Xfinity Channel 3 and AT&T Uverse channel 99) at the following times: Sundays, 9:30 a.m. and 7:30 p.m.; Mondays, 7:30 p.m., Tuesdays and Thursdays, 9:30 a.m. and Saturdays, 9:30 a.m. and 7:30 p.m. You can view the program online by visiting www.youtube.com/cityofmurfreesboro or www.murfreesborotn.gov/storytellers.


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King's Shilling Tankard - with free engraving
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Legend tells us that 18th century Royal Navy press gangs (recruitment officers) used to hide a signing-up bounty (the 'King's Shilling') in the 'free pints' that they offered to unsuspecting sailors in waterside taverns.
Drinking the beer was deemed to be acceptance of the money, and commitment to recruitment in the King's service (harsh discipline and dreadful food!).
The glass-bottomed tankard was said to have been invented so that men would spot the trick before it was too late.
In commemoration, our hefty, one-pint, Sheffield pewter tankard has a double glass bottom with a genuine old shilling sandwiched between. The King's Shilling story is engraved on one side, with a personalisation panel for up to three initials on the reverse.
GREAT OFFER! Engraving of up to 3 letters is included in the price.
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|28 Hour(s) ago
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text:
Berkeley Automounter
This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages)(Learn how and when to remove this template message)
|Erez Zadok
|Stable release
6.1.5 / May 11, 2006
|Preview release
6.2a2 / May 11, 2006
|Operating system
|NFS Automounter
|BSD License
The Berkeley Automounter (or amd) first appeared in 4.4BSD, and is a computer automounter daemon. The original Berkeley automounter was created by Jan-Simon Pendry in 1989 and was donated to Berkeley.[1] After languishing for a few years, the maintainership was picked up by Erez Zadok, who has maintained it since 1993.
The am-utils package which comprises amd is included with FreeBSD, NetBSD, and OpenBSD. It is also included with a vast number of Linux distributions, including Red Hat Enterprise Linux, Fedora Core, ASPLinux, Trustix, Mandriva, and others.
The Berkeley automounter has a large number of contributors, including several who worked on the original automounter with Jan-Simon Pendry.
It is one of the oldest and more portable automounters available today, as well as the most flexible and the most widely used.[citation needed]
There are a few "side effects" that come with files that are mounted using automounter. These may differ depending on how the service was configured
- Access time of automounted directories is set to the time automounter was used to mount them (after the directories are accessed, this statistic obviously changes).
- On some systems, directories are not visible until the first time they are used. This means commands such as ls will fail.
- If mounted directories are not used for a period of time, directories are unmounted.
- When automounter mounts directories, they are said to be owned by root until one uses them, at that time the correct owner of the directory shows up.
- ^ Jan-Simon Pendry (1989-12-01). "''Amd'' - An Automounter". Newsgroup: comp.unix.wizards. Retrieved 2007-12-23.
External links[edit]
- Am-utils Home Page (home of amd)
- RPMs from rpmfind.net
|This Unix-related article is a stub. You can help Wikipedia by expanding it.


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Ghatu Subhash
Editorial Board, Mechanics of Materials University of Florida, Gainesville, Florida, USA Send an email to Ghatu Subhash
To send an email to Ghatu Subhash please complete the short form below. Please note that all enquiries should relate specifically to Mechanics of Materials. All the fields are required so please make sure you complete them all otherwise we won't be able to send your message.


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Motion Pictures, Wizards Training Camp; John Wall: 'You know I'm nice'
Media Day for the Washington Wizards fell right on the heeds of Training Camp ending on Thursday afternoon. It was a bit of a frenzied whirlwind, as expected, and more coverage is to come. The lessons taught and the whirlwind of basketball don't end, of course. The first preseason game is on Friday, and the smell of popcorn is in the air.
There wasn't much basketball action, however, for the media to witness during Thursday's session. After team owner Ted Leonsis spoke, the display of players was pretty much relegated to some individual shooting drills. Then Flip Saunders gave rookie Shelvin Mack the DC Hard Hat for a day of work well done. Mack's teammates congratulated him by pounding him on the head once he donned the hat.
So, in lieu of footage from today, let's look back at a couple quick training camp videos shot by TAI's Adam McGinnis and John Converse Townsend.
McGinnis' highlights of John Wall from Training Camp Day 3.
As Wall puts it best, "You know I'm nice." He was talking about his abilities on the sticks in the NBA 2K video game franchise, but it certainly applies to the real basketball court as well, as it evident.
Townsend brings us a two-minute clip of full court 5-on-5 action from Day 6.
Wanna see Chris Singleton confidently hit a three-pointer and hold his follow-through? It's in there. Also look for
Singleton [Correction: Trevor Booker] swatting a Mardy Collins lay-up attempt off the backboard.
Related Posts
- Key Legislature: Wizards 121 vs Nets 103 — Without Wall, Washington Weathers Storm
- Crossed Up and Shot Down in LA — Wizards at Clippers, DC Council 77
- Key Legislature: Wizards 109 at Clippers 114 — California Dreaming of Fat Ladies Singing
- Key Legislature: Wizards 106 at Suns 99 — Making Good on Meaningless Promises


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realmagick.com The shrine of knowledge.
Vedas In Ayurveda
A selection of articles related to vedas in ayurveda.
Original articles from our library related to the Vedas In Ayurveda. See Table of Contents for further available material (downloadable resources) on Vedas In Ayurveda.
- Mother Of The Gods And The Father Of The Gael
- There is no surviving, or as yet translated, Creation story within Irish mythology. We learn from the Lebor Gabala Erenn, a text from the Christian Middle Ages, of the Tuatha De Danann, or "People of the Goddess Danu", who came to Ireland either...
Deities & Heros >> Celtic, Welsh, Irish & Brittish
- Looking For The Hub Of The Sacreed Wheel: Part 1
- It is often said that all paths are like spokes on a wheel. We start at the rime and follow a spoke to the hub of central truth from which all paths arise and to which they all return. Those of you who've been following my articles should also know that to a...
Religion & Philosophy >> Religions
- The Celtic Vedic Connection, Part I
- Of all the great ancient cultures perhaps no two share more parallels than those of the Celtic and Vedic peoples. A deep rooted affinity runs between them, what is present in one is mirrored in the other. Myths, Gods, Goddesses, even fairy tales bear a...
Religions >> Druidism
- Bibles Do Not Equal Wisdom
- Bibles do not equal wisdom. In other words, all forms of spiritual text no matter how eloquently stated, cannot actually grant wisdom to the reader, merely through the act of reading. Words are only the representations of things, but not the things themselves....
Religion & Philosophy >> Religions
- Hinduism: An Overview
- Hinduism is believed to be the oldest organized religion in the world. It ranks as the third largest religion in the world after Christianity and Islam.
Religion & Philosophy >> Religions
Vedas In Ayurveda is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Vedas In Ayurveda books and related discussion.
Suggested Pdf Resources
- ayurvedic concepts in vedas - URP Journals
- Mar 16, 2011 Ayurveda and Veda have a relation in depth Ayurveda is not a merely medical system. ... Vedas are ancient doctrines of great knowledge on.
- urpjournals.com
- Medical Sciences in Vedas - Arya Samaj
- The word for medical sciences in Vedas is Ayurveda. The word Ayurveda comes from. Sanskrit word Ayuh (life) and Veda(knowledge), means the knowledge or ...
- aryasamaj.com
- A Critical Review of Emergence of The Ayurvedic Tradition In Vedic
- briefly review the concepts of ayurveda mentioned in the Vedas and to study their effects ... Key words: Rishis, literature, Vedas, Ayurveda, Traditional medicine.
- www.anantaajournal.com
- Ayurveda:Life, Health & Longevity - Ayurvedic Institute
- From the youngest of the Vedas, the Atharva-Veda, developed Ayurveda, probably with the help of residual Harappan knowledge. At the turn of first millennium ...
- www.ayurveda.com
- SOMALATA – A Pioneer Herb in the entire Plant Kingdom
- There are three Vedas called. RigVeda, YajurVeda, and SamaVeda. The fourth one AthrvaVeda is the extract of all the three Vedas.
- www.ijrpbsonline.com
Suggested News Resources
- RSS sings a new tune: Restriction on entry of women in temples unfair, says Sangh
- "Women have been learning the Vedas and also performing religious practices," the RSS leader said. ... There is also need to spread the medical education, inclusion of other branches like Ayurveda and Unani is also required," Deshpande said.
- From Ravi Shankar to Gurudev Sri Sri Ravi Shankar; His Journey, Controversies
- Born on 13 May 1956 in Tamil Nadu, India, He was named "Ravi" because his birth was on a Sunday, and "Shankar" after the eighth-century saint, Adi Shankara. (Pic: AOL). Guruji-Bio-Carousal-1-sample-2.
- Her story
- Giving people an option to use age-old ayurvedic treatments was always an idea I wanted to share with the world. There are various consequences caused by consuming parabens often, and I personally never wanted to encourage them for my beauty brand.
- Need to document, validate medical heritage
- Dhiman said that right from the Vedic times to the present, new remedies were being added from time to time to the Ayurvedic Pharmacopoeia. The validation of claims and traditions had become more relevant with deforestation, he said.
- Local Vedic astrologers decipher map for healing inner cosmos
- An ancient practice that is sister to yoga and Ayurveda, Vedic astrology is not an instrument of fortunetelling, says Kurczak, founder of Asheville Vedic Astrology.
Suggested Web Resources
- Ayurveda - Wikipedia, the free encyclopedia
- Ayurveda significantly developed during the Vedic period and later some of the non-Vedic systems such as Buddhism and Jainism also developed medical ...
- en.wikipedia.org
- Ayurveda - वेद Veda
- Ayurveda is a Sanskrit term, made up of the words "ayus" and "veda." "Ayus" means life and "Veda" means knowledge or science. The term "ayurveda" thus ...
- veda.wikidot.com
- Historical development of basic concepts of Ayurveda from Veda up
- Introduction. Glimpses of the concepts expounded in Ayurvedic Samhitas have been given. Whether their roots are found in earlier works and whether they have ...
- www.ncbi.nlm.nih.gov
- ayurvedic concepts in vedas - URP Journals
- Mar 16, 2011 Ayurveda and Veda have a relation in depth Ayurveda is not a merely medical system. ... Vedas are ancient doctrines of great knowledge on.
- urpjournals.com
- Ayurveda - History and Philosophy
- Ayurveda is an ancient system of life (ayur) knowledge (veda) arising in India thousands of years ago. Ayurveda theory evolved from a deep understanding of ...
- www.healthandhealingny.org
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
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