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Patent application title: Arginine Heteromers for Topical Administration
Jacob M. Waugh (Mountain View, CA, US)
IPC8 Class: AA61K849FI
USPC Class:
424 59
Class name: Drug, bio-affecting and body treating compositions topical sun or radiation screening, or tanning preparations
Publication date: 2009-08-27
Patent application number: 20090214452
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The invention is directed to a strategy for providing therapeutic or
cosmetic benefit to skin by topically applying arginine chemically bound
to a second (non-oligo arginine) compound in order to increase
transepithelial delivery of arginine through a combination of increased
solubility and flux across the skin. The arginine heteromers of the
invention can add other complementary or beneficial properties for the
skin beyond those that are arginine-related.
1. A heteromer of formula I:A-R Iwherein A is arginine covalently bound
to a second compound R such that the guanadino group of the arginine
remains unreacted and wherein R is an organic molecule wherein the
heteromer has greater flux across the skin than arginine alone.
2. The heteromer of claim 1 wherein R is a vitamin.
3. The heteromer of claim 2 wherein R is vitamin C.
4. The heteromer of claim 2 wherein R is vitamin E.
5. The heteromer of claim 2 wherein R is vitamin D.
6. The heteromer of claim 1 wherein R is a fatty acid.
7. The heteromer of claim 6 wherein R is palmitic acid.
8. The heteromer of claim 1 wherein R is a retinoid.
9. The composition of claim 1 wherein A and R are bound by an amide bond.
10. The heteromer of claim 1 wherein A and R are bound by an ester bond.
11. A composition comprising a heteromer of formula IA-R Iwherein A is arginine covalently bound to a second compound R such that the guanadino group of the arginine remains unreacted and wherein R is an organic molecule wherein the heteromer has greater flux across the skin than arginine alone.
12. The composition of claim 11 wherein R is a vitamin.
13. The composition of claim 12 wherein R is vitamin C.
14. The composition of claim 12 wherein R is vitamin E.
15. The composition of claim 12 wherein R is vitamin D.
16. The composition of claim 11 wherein R is a fatty acid.
17. The composition of claim 16 wherein the fatty acid is palmitic acid.
18. The composition of claim 11 wherein R is a retinoid.
19. The composition of claim 11 wherein A and R are bound by an ester bond.
20. The composition of claim 11 wherein A and R are bound by an amide bond.
21. The composition of claim 11 further comprising skin-care preparations.
22. The composition of claim 11 further comprising bath-preparations.
23. The composition of claim 11 further comprising cosmetic preparations.
24. The composition of claim 11 further comprising eye-care preparations.
25. The composition of claim 11 further comprising lip-care preparations.
26. The composition of claim 11 further comprising sunscreen preparations.
27. The composition of claim 11 further comprising hair care preparations.
28. The composition of claim 11 further comprising an anti-acne preparation.
29. The composition of claim 11 further comprising anti-oxidant preparations.
30. The composition of claim 11 further comprising anti-psoriasis preparations.
31. The composition of claim 11 further comprising corticosteroid preparations.
32. A method for providing a beneficial effect to skin comprising:topically applying a composition comprising a heteromer of formula I:A-R Iwherein A is arginine covalently bound to a second compound R such that the guanadino group of the arginine remains unreacted and wherein R is an organic molecule wherein the heteromer has greater flux across the skin than arginine alone.
33. The method of claim 32 wherein the beneficial effect is promoting angiogenesis in hair follicles.
34. The method of claim 32 wherein the beneficial effect is reducing signs of skin aging.
35. The method of claim 32 wherein the beneficial effect is reducing symptoms of acne.
36. The method of claim 32 wherein the beneficial effect is reducing or preventing damage caused by exposure of the skin to sunlight.
37. The method of claim 32 wherein the beneficial effect is reducing the appearance of fine lines and wrinkles in the skin.
38. The method of claim 32 wherein the beneficial effect is reducing glandular secretions.
39. The method of claim 32 wherein the beneficial effect is providing an anti-oxidant to the skin.
40. The method of claim 32 wherein the composition is applied to smooth the texture of skin.
41. The method of claim 32 wherein the composition is applied to provide moisturizing and lubricating benefit in the skin.
42. The method of claim 32 wherein the second compound is palmitic acid.
43. The method of claim 42 wherein the composition is applied to smooth the texture of skin.
[0001]This application claims the benefit of priority to U.S. Provisional
Application No. 60/755,203 filed Dec. 30, 2005, and incorporates by
reference this entire provisional application in its entirety.
[0002]The invention relates to arginine heteromers which have an improved ability to penetrate mammalian skin and provide beneficial effects for the health and appearance of skin.
[0003]L-Arginine is a naturally occurring amino acid which plays many essential roles in the human body. One of these roles is as a substrate for nitric oxide synthase (NOS). Under normal conditions in the human body, nitric oxide (NO) has a half-life of only 3-5 seconds due to its swift inactivation by oxyhemoglobin when forming methemoglobin. Cyclic GMP is a downstream product of NO and controls most of the biological effects of NO, while the nitric oxide synthase (NOS) family of enzymes controls NO production. The three main types of NOS are: 1) inducible (iNOS); 2) neuronal (nNOS); and 3) endothelial (eNOS), all of which are found in the skin. All three of these isoforms require oxygen and nicotinamide adenine dinucleotide phosphate (NADPH) as substrates. Asymmetric dimethyl L-arginine (ADMA) is a basal inhibitor of the NOS family, and elevated levels of this substance have been found in cases of hypertension, hypercholesterolemia and other diseases associated with impaired vasodilatation. Elevating the concentration of L-arginine has been shown to overcome the inhibitory effect of ADMA without leading to increased NO production.
[0004]NO is known to play an important role in the physiology of the skin with effects on the microvasculature and blood flow, maintenance of barrier function, inflammatory skin conditions such as psoriasis, response to ultraviolet light and wound healing. Increased tissue NO concentration stimulates local vasodilatation and angiogenesis. However, NO diffuses freely so that it is difficult to maintain effective concentrations in the skin. An alternate strategy would be to elevate arginine concentration to increase the amount of substrate for NOS to use in the production of NO. However, arginine by itself has very poor skin penetration. One solution to this problem in other tissues has been to link L-arginine into oligomers from 7 to 15 units in length (oligoarginine). These compounds can effectively penetrate skin and increase concentrations of NO and have even been shown to transport covalently bound agents across cytoplasmic membranes (Cosmetic Formulations containing L-Arginine Oligomers, WO 03/072039 A2). However, it was not clear whether these benefits were due to the relatively unique transport properties of oligoarginine.
[0005]A specific example of the importance of angiogenesis in the skin is in the maintenance of healthy hair follicles. During the follicle life cycle, angiogenesis is largely controlled by a balance between pro- and anti-angiogenic factors. It has been shown that the anagen phase is especially dependent on pro-angiogenic factors to stimulate the increased blood flow necessary for the increased nutritional needs of the follicle (Cosmetic Formulations containing L-Arginine Oligomers, WO 03/072039 A2).
[0006]The invention described herein is directed to a strategy for providing therapeutic or cosmetic benefit to skin by topically applying arginine chemically bound to a second (non-oligoarginine) compound in order to increase transepithelial delivery of arginine through a combination of increased solubility and flux across the skin. The arginine heteromers of the invention can also provide other complementary or beneficial properties for the skin beyond those that are arginine-related.
[0007]This invention provides a strategy for providing therapeutic or cosmetic benefit to skin by topically applying an arginine heteromer. An arginine heteromer is a single arginine molecule chemically bound to a second (non-oligoarginine) compound in order to increase transepithelial delivery of the arginine heteromer through one or more of increased solubility and flux across the skin. The general structure of the arginine heteromer is given in formula I:
[0008]Formula I
[0009]Where A is a single arginine molecule having a free guanidine group and R is a second compound which is an organic molecule that is not arginine or oligo-arginine. The arginine molecule may be bound to the second compound through either its carboxy or amino group and the guanidino group of the arginine remains free. The arginine heteromer may have greater flux across the skin than monomeric arginine alone.
[0010]The second compound of the arginine heteromers of the invention can add other complementary or beneficial properties for the skin beyond those that are arginine-related. More specifically, the second compound of the heteromer can provide other benefits such as, antioxidant capacity, angiogenesis augmentation, reduction in the symptoms of acne, reduction of glandular secretions, reduction of the effects of aging, or wrinkle reduction. One example of a specific embodiment of the invention is arginine bound to vitamin E by an ester linkage. Also, relative to oligomer strategies, these arginine heteromers offer significant safety and cost benefits.
[0011]Another embodiment of the invention provides a method for providing a beneficial effect to skin comprising topically applying a composition comprising an arginine heteromer of Formula I. The beneficial effect can include, but is not limited to, reducing or preventing damage caused by sunlight, providing antioxidant activity, reducing the appearance of fine line and wrinkles in the skin, reducing glandular secretions, reducing the effects of aging, treating acne and inducing angiogenesis in hair follicles.
[0012]FIG. 1. Diagram showing the formation of arginine heteromer from vitamin C where R is hydrogen or Boc protected arginine.
[0013]FIG. 2. Diagram showing the formation of arginine heteromer from vitamin C where G is hydrogen or deprotected arginine.
[0014]FIG. 3. An IR graph showing the Arginine-Vitamin C compound.
[0015]FIG. 4. Diagram showing the formation of arginine heteromer from vitamin D3.
[0016]FIG. 5. A TLC showing the Arg-Vit D3 product.
[0017]FIG. 6. Effect of topically applied L-Arginine heteromers on human forehead perfusion.
[0018]This invention discloses a number of arginine heteromers which serve as substrates for nitric oxide synthase (with or without processing of the heteromer) and which have increased flux, with respect to native arginine, of the heteromer across skin when applied topically. In other embodiments for example, the heteromers also provide additional properties such as antioxidant activity.
[0019]The heteromers of this invention have a structure as in Formula I:
where A is a single arginine molecule covalently bound to a second compound R. The arginine molecule may be bound through its free carboxy or amino group and the arginine guanidino group remains unreacted and free. The second compound, R, is an organic molecule that is not arginine or oligo-arginine. In an embodiment of this invention the second compound R further provides one or more of the properties selected from the group consisting of improving the solubility in oil or in water of the arginine heteromer compared to arginine alone, and improving the rate of flux of the arginine heteromer across skin compared to arginine alone. The second compound may further provide additional benefits to the skin. The second compound is compatible for contact with mammalian tissues by being non-toxic, non-allergenic and non-irritating. Examples of suitable second compounds include, but are not limited to, vitamins, retinoids and fatty acids.
[0020]Ascorbic acid (vitamin C), alpha-tocopherol (vitamin E) and retinoids (vitamin A) when used in accordance with this invention may provide beneficial properties for skin. Ascorbic acid stimulates the synthesis of connective tissue and in particular it stimulates and regulates the production of collagen. It acts to help prevent or minimize lipid oxidation and other forms of cellular damages resulting form prolonged exposure to ultraviolet rays. It is believed that ascorbic acid helps to inhibit the formation of melanin and the release of histamine from cellular membranes. Ascorbic acid compensates for vitamin E deficiency in the skin, helps prevent discoloration of the skin, and it has an anti-free radical activity. Alpha-tocopherol is an antioxidant for protecting the phospholipids of the cell membrane and harmful effects of free radicals (J. B Chazan et al. Free Radicals and Vitamin E. Cah. Nutr. Diet. 1987 22 (1):66-76). Retinoids block mediators of inflammation in the skin and increase the production of procollagen leading to higher amounts of type I and type III collagen.
[0021]In some embodiments, the second compound is a vitamin such as vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin B9, vitamin B 12, vitamin C, vitamin D1, vitamin D2, vitamin D3, vitamin D4, vitamin D5, vitamin E, and vitamin K.
[0022]In other embodiments the second compound is a retinoid. Retinoids include retinol, natural and synthetic analogs of vitamin A (retinol), vitamin A aldehyde (retinal), vitamin A acid (retinoic acid), including all-trans, 9-cis, and 13-cis retinoic acids, etretinate, and others as described in EP-A2-0 379367, U.S. Pat. No. 4,887,805, and U.S. Pat. No. 4,888,342 (the disclosures of which are all incorporated herein by reference). Various synthetic retinoids and compounds having retinoid activity are expected to be useful in this invention, to the extent that they exhibit retinoid activity in vivo, such as in the following U.S. Pat. Nos. 5,514,825; 5,698,700; 5,696,162; 5,688,957; 5,677,451; 5,677,323; 5,677,320; 5,675,033; 5,675,624; 5,672,710; 5,688,175; 5,663,367; 5,663,357; 5,663,347; 5,648,514; 5,648,503; 5,618,943; 5,618,931; 5,618,836; 5,605,915; 5,602,130. Still other compounds described as having retinoid activity are described in other U.S. Pat. Nos. 5,648,563; 5,648,385; 5,618,839; 5,559,248; 5,616,712; 5,616,597; 5,602,135; 5,599,819; 5,556,996; 5,534,516; 5,516,904; 5,498,755; 5,470,999; 5,468,879; 5,455,265; 5,451,605; 5,343,173; 5,426,118; 5,414,007; 5,407,937; 5,399,586; 5,399,561; 5,391,753; and the like, the disclosures of all of the foregoing and following patents and literature references hereby incorporated herein by reference.
[0023]In further embodiments of the invention, the second compound is a fatty acid. Fatty acids are monocarboxylic acids having a saturated or unsaturated aliphatic tail. As defined in the International Cosmetic Ingredient Dictionary and Handbook, 7th Ed. (1997) volume 2, page 1567 (the disclosure of which is incorporated herein by reference) fatty acids have about 7 or more carbon atoms. For example, palmitic acid is a saturated fatty acid found in palm oil and other fats. It is the most abundant natural fatty acid. Palmitic acid is also one of the skin's major fatty acids produced by the sebaceous glands. Palmitic acid is used in skin care and cosmetic preparations as a moisturizing agent. It normalizes skin to a normal, healthy state and stabilizes oil balance. It softens skin and acts like an antikeratinizing agent. It is also used as an emulsifier, surfactant and a formula texturizer. Esters of palmitic acid are used to impart silkiness to the skin and hair. The palmitic acid serves as a carrier to allow penetration of the pentapeptide into the skin. It is widely used as a lubricant.
[0024]In addition to palmitic acid, suitable fatty acids include, but are not limited to, undecylenic, palmitoleic, oleic, linoleic, linolenic, arachidonic and erucic acids. Additional suitable fatty acids can be found in the International Cosmetic Ingredient Dictionary and Handbook, 7th Ed. (1997) volume 2, page 1567.
[0025]The arginine molecule and second compound are bound by a covalent linkage. The kinds of linkages include, but are not limited to, ester, amide, ether and carbamide linkages. Embodiments of the invention include, but are not limited to, heteromers of arginine with vitamins, retinoids or fatty acids.
[0026]The arginine heteromer is delivered across the skin in an amount effective to produce a beneficial effect on the skin. As used herein, the term "beneficial effect" includes any improvement in the appearance or feel of the skin or any protective effect from damage to the skin resulting from external sources such as sunlight or from internal sources such as the effects of aging. The term "effective amount" refers to that amount of the arginine heteromer which penetrates the stratum corneum layer of the skin that is sufficient to produce the desired beneficial effect.
[0027]Once in skin, the heteromers of this invention may degrade to release arginine and the second compound. It is not necessary for the heteromer to degrade as long as the guanidino group of the arginine portion of the heteromer remains unreacted and free so that it may serve as a substrate for nitric oxide synthase. The arginine heteromers can be stabilized in formulations prior to application. Thus, higher rates of transepithelial delivery of arginine can be accomplished in a manner relevant to providing the intended beneficial effect.
[0028]The arginine heteromers of the invention may be used in a number of cosmetic or dermatological compositions intended for topical application. Because the arginine heteromers can stimulate angiogenesis in hair follicles, these compositions may be used for the prevention of hair loss or to enhance hair growth. When used to affect hair growth these compositions are applied to the scalp, eyebrows or eyelashes. The compositions may be applied to the lips to improve color and plumpness. When applied to the skin, the arginine heteromer compositions may be used to reduce the appearance of fine lines and wrinkles, improve skin elasticity, reduce puffiness, smooth skin texture, provide a silky feel to the skin, provide a moisturizing effect, provide lubrication, provide a natural blush, reduce the effects of aging or provide other cosmetic benefits.
[0029]For application to skin or lips, the arginine heteromers are included in compositions that comprise cosmetically or dermatologically acceptable carriers or vehicles that are suitable for the area of the body to which they will be applied. The term "cosmetically or dermatologically acceptable," as used herein, includes the compositions or compounds suitable for use in contact with physiologic tissues without undue toxicity, incompatibility, instability and the like.
[0030]A number of compositions and formulations typically used in products applied to the skin, lips and hair can be used with the arginine heteromers of the invention. These include but are not limited to skin-care preparations such as skin-washing and cleansing preparations, soap less detergents, body lotions, emulsions or skin oils, skin peel or scrub preparations or peeling masks; bath preparations such as liquid or solid bath preparations, bath cubes and bath salts; cosmetic personal care preparations such as facial make-up in the form of day creams or powder creams, face powder, rouge or cream make-up; eye-preparations such as eye shadow, mascara, eyeliner or eye creams; lip-care preparations such as lipsticks, lip gloss or lip contour pencils; nail-care preparations such as nail polish and nail varnish; foot-care preparations such as foot baths, foot powders, foot creams or foot balsams, special deodorants and antiperspirants or callous removing preparations; sunscreen preparations such as lotions, creams, oils, sun blocks, pre-tanning preparations, after-sun preparations, skin-tanning preparations or self-tanning creams; hair-care or hair-treatment preparations such as shampoos, conditioners, styling creams, styling gels, foams, rinses, hairsprays or hair dyes and colorants.
[0031]The compositions of the invention may be in the form of solutions, emulsions, micro emulsions, suspensions, creams lotions, gels, waxy products such as for example lipstick and powders and other solid cosmetics of various types including but not limited to antiperspirants and eyeliner.
[0032]The arginine heteromer compositions of the invention can also comprise other ingredients commonly used in skin care and hair care products such as antimicrobials, moisturizers, hydration agents, penetration agents, preservatives, emulsifiers, natural or synthetic oils, solvents, surfactants, detergents, gelling agents emollients, antioxidants, fragrances fillers thickeners waxes, odor absorbers, dyestuff, coloring agents, powders, viscosity-controlling agents, anesthetics, anti-itch agents, botanical extracts, conditioning agents, darkening or lightening agents, glitter, hair pigment additives, humectants, mica, minerals, polyphenols, silicones or silicone derivatives, sun blocks, vitamins, phytomedicinals and other compounds as listed in the International Cosmetic Ingredient Dictionary and Handbook, 7th Ed. (1997).
[0033]Compositions of the invention can comprise active ingredients other than the arginine heteromers. For example, anti-acne agents including but not limited to salicylic acid, benzoyl peroxide, resorcinol, and sulfur; anti-oxidants including but not limited to ascorbic acid, caffeic acid, cysteine, hydroquinone and tocopherol; compounds for the treatment of psoriasis including but not limited to salicylic acid, coal tar and retinoids; and corticosteroids including but not limited to cortisone, hydrocortisone and prednisone.
[0034]In some embodiments of the invention, the arginine heteromers are used for treating, ameliorating or preventing skin aging. Skin damage due to aging may include but is not limited to both fine and deep wrinkles, skin lines, crevices, bumps, large pores, scaliness, loss of skin elasticity, sagging, loss of skin firmness or tightness, discoloration, hyperpigmented regions such as age spots and freckles, keratosis, abnormal differentiation, hyperkeratinization, elastosis, collagen breakdown, and other histological changes in the stratum corneum, dermis, epidermis, the vascular system of the skin, and underlying tissues especially those close to the skin. The skin aging may be due to chronological aging or to extrinsic factors such as prolonged exposure to sunlight but the compositions of the invention are expected to treat, ameliorate or prevent these and other forms of skin damage regardless of the mechanism of origin.
[0035]Compositions of this invention may be in the form of products to be applied to the skin or epithelium of subjects or patients, i.e. humans or other mammals who could benefit from the treatment. The compositions and methods of this invention have pharmaceutical and/or health-related applications and may be used. to provide treatment for various medical conditions to persons who might need or benefit from them. For example, inventions described herein may be used for treating hyperhidrosis, acne or other conditions involving the excess production of secretions or sweat.
[0036]In general, the compositions of this invention are prepared by mixing the arginine heteromer with a carrier, and usually with one or more additional pharmaceutically acceptable carriers or excipients. The arginine heteromer is present in the compositions at a concentration of from about 0.001% to a saturated solution, in some embodiments from about 0.01% to about 30% and in other embodiments from about 0.1% to about 20%. In their simplest form, the compositions of this invention may contain a simple aqueous pharmaceutically acceptable carrier or diluent, such as buffered saline. However, the compositions may contain other ingredients typical in topical pharmaceutical or cosmeceutical compositions, that is, a dermatologically or pharmaceutically acceptable carrier, vehicle or medium, i.e. a carrier, vehicle or medium that is compatible with the tissues to which they will be applied. The term "dermatologically or pharmaceutically acceptable," as used herein, includes compositions or components that are suitable for use in contact with specific tissues or for use in patients in general without undue toxicity, incompatibility, instability, and the like. As appropriate, compositions of the invention may comprise any ingredient conventionally used in the fields under consideration, and particularly in cosmetics and dermatology. The compositions also may include a quantity of a small anion, preferably a polyvalent anion, for example, phosphate, aspartate, or citrate.
Example 1
[0038]To develop novel conjugations of arginine, arginine-vitamin C, for improved flux and increase therapeutic benefit.
[0039]Arg-Vitamin C Preparation:
[0040]A heteromer of vitamin C and arginine was prepared by preparing a solution of BocArg(Boc2)OH (159 mg, 0.33 mmol) in dimethylformamide and adding ethylene dichloride (EDC, 70 mg., 0.36 mmol) followed by 4-dimethylaminopyridine (DMAP, 2 mg, 0.02 mmol). The reaction was stirred for 2 hours at room temperature. A TLC analysis was performed to check the progress of the reaction (vide infra). An additional 22.7 mg EDC was added and the reaction stirred for 1/2 hour. The reaction was observed to turn light purple. The reaction yielded 44 mg of compound 2. IR of compound was performed and is shown below. MS (ES): 1101.9, 745.6, 645.5, 630.6, 530.6, 502.4
[0041]Deprotection of C-ArG (to Remove Boc):
[0042]The Boc protective groups of compound 2 were removed by preparing a solution of 25 mg compound 2 in dichloromethane (˜10 ml) and adding ˜2 ml trifluoroacetic acid while stirring in an ice bath. The mixture was stirred for 1 hour then allowed to warm to room temperature. TLC (10% MeOH/dichloromethane) after 2 hours at room temperature showed loss of starting material and strengthening of the origin (product) spot. Compound 4 afforded a UV active spot of modest Rf in that solvent system. Solvent was removed under reduced pressure and the residue was azeotroped with twice with toluene to give 25 mg of compound 4.
[0044]This experiment demonstrates the synthesis of Arginine-Vitamin C compound.
Example 2
[0046]A heteromer of arginine and vitamin D3 was prepared by dissolving triphosgene (0.1 g, 0.33 mmole) in 1 ml anhydrous methylene chloride. The triphosgene solution was added dropwise to a cooled solution (0 degrees) of vitamin D3 (0.385 g, 1 mmole) and DMAP (0.61 g, 5 mmole) in 2 ml methylene chloride. The reaction mixture was allowed to stir at zero degrees for 1.5 hours. A mixture of L-Arginine (0.261 g, 1.5 mmole) and N,N-Diisopropylethylamine (523 ul, 3 mmole) was added dropwise to the triphosgene mixture. The reaction was allowed to warm to room temperature overnight and yielded 205 mg white solid (35% yield). This experiment demonstrates the synthesis of Arginine-Vitamin D3 heteromer and the TLC is shown in FIG. 5.
Example 3
[0047]In vivo cumulative efficacy for topical delivery of arginine across murine skin.
[0049]The potential for a heteromer of arginine to cross the skin and exert previously characterized benefits related to arginine/NOS activity was evaluated by examining arginine-vitamin E and arginine-palmitate heteromers in an animal model system. While both heteromers improve the lipid solubility relative to arginine alone and should increase transdermal flux, the vitamin E heteromer is also expected to afford additional functional benefits due to its anti-oxidant properties.
[0051]Arginine-palmitate and arginine-vitamin E heteromers were synthesized from L-arginine (Batch #02202JA, A92406-25G, Sigma Aldrich). The stock solutions were prepared by adding the following:
[0052]1. Arg-palmitate: 0.9996 g of arginine +palmitate were dissolved in 6 ml of jojoba oil (Essential Wholesale, Portland, Oreg.), then diluted with 6 ml (1:1 dilution) of Cetaphil cream.
[0053]2. Arg-vitamin E: 0.419 g of arginine+vitamin E were dissolved in 6 ml of deionized H2O then diluted with 6 ml (1:1 dilution) of Cetaphil cream.
[0054]3. Cetaphil: prepared with 6 ml of cetaphil only.
[0055]Daily-dose topical treatments of metered 200 μl aliquots were prepared for treatments of Arg-palmitate, Arg-vitamin E, or Cetaphil control in 650 μl microcentrifuge tubes.
[0056]Topical Application of Arginine Compounds
[0057]Study Procedures:
[0058]Animals (C57 black 6 female mice, Charles River Laboratories, Wilmington, Mass.) were anesthetized via inhalation of isoflurane mixed with oxygen and then injected with 0.5 ml rodent anesthetic cocktail (3.75 ml of 100 mg/ml Ketamine, 3.00 ml of 20 mg/ml Xylazine, and 23.25 ml of saline) intraperitoneally. The animals were supplemented with isoflurane as necessary. Treatment groups contained 4 mice each and the control group 3 mice. After being anesthetized, a 2.0 cm×2.0 cm dose site on the dorsum of each mouse was carefully shaved with a hair clipper on the first day of treatment application and animals underwent depilatory treatment in the same dorsal region using a rosin mixture (Surgiwax, Ardell International, Los Angeles, Calif.). Animals were anesthetized via inhalation of isoflurance only during the application of treatments in Cetaphil moisturizing cream (Galderma, Fort Worth, Tex.) and had metered 200 μl doses of the appropriate treatment applied to the cranial portion of dorsal back skin (selected because the mouse cannot reach this region with mouth or limbs). Animals remained under anesthesia for 1-2 minutes while the appropriate treatment was applied into the skin with small metal spatula. Animals recovered in a controlled heat environment to prevent hypothermia and once responsive were provided food and water ad libitum overnight. This procedure was repeated once daily at the same approximate time of day for 7 days. After the day 7 treatment, mice were euthanized via inhalation of CO2, and treated skin segments were harvested at full thickness by a blinded observer at 24 hours post application of the last treatment. Treated segments were divided into three equal portions and the cranial portion was fixed in 10% neutral buffered formalin for 12-16 hours then stored in 70% ethanol until paraffin embedding. The central portion was employed for Hematoxylin & Eosin for morphological assessment and Chloroacetate esterase staining to evaluate neutrophil infiltration as an indicator of inflammation. The treated caudal segment was snap frozen for solubilization studies.
[0059]Image and Statistical Analysis:
[0060]High resolution digital images of each section were obtained using a Retiga 1300B camera (QImaging, Burnaby, BC, Canada). Images were analyzed using Image-Pro Plus analysis software (Media Cybernetics, Silver Springs, Md.) to determine morphological assessment and expressed as positive pixels. Mean and standard error were subsequently determined for each group using Statview software (Abacus, Berkeley, Calif.), with analysis of significance at 95% confidence in Wilcoxon signed ranks.
[0061]Results for Arg-Palmitate and Arg-Vitamin E:
[0062]Mean, standard error, and p-values are shown in Table 1 for groups Arg-palmitate, Arg-vitamin E and control.
TABLE-US-00001 TABLE 1 Table 1. The morphological assessment of dermal thickness, hair length, epidermal thickness, fat thickness/density. Mean Std. Error P value Dermis: Arg-palmitate 32596 1398 0.596 Arg-Vitamin E 35779 1425 0.038 Control 31405 1959 Hair: Arg-palmitate 17149 1908 0.668 Arg-Vitamin E 18316 1502 0.044 Control 15613 1186 Epidermis: Arg-palmitate 11086 749 0.939 Arg-Vitamin E 16475 1513 0.0004 Control 11082 890 Fat: Arg-palmitate 27918 2662 0.820 Arg-Vitamin E 21386 1092 0.007 Control 27419 1849
[0063]Arginine heteromers have sufficient flux across skin when applied topically to afford several therapeutic benefits related to arginine and/or the additional functionality of the heteromer.
Example 4
[0065]The potential for a heteromer of arginine to cross the skin and exert previously characterized benefits related to arginine/NOS activity was evaluated by examining several arginine heteromers in a human model system. All heteromers improve the lipid solubility relative to arginine alone and should increase transdermal flux and perfusion.
[0067]Flowmeter Probe Modification and Arginine Heteromer Formulations
[0068]Lip balm formulations were obtained consisting of Anhydrous Lanolin USP, Ethyl Methylphenylglycidate, Cetyl Esters, D-Alpha Tocopheryl Acetate USP, Petrolatum USP, Salicylic Acid USP, Benzyl Cinnamate and 4.0 mg/ml of either L-Arg(9) (an oligomer consisting of nine arginines), L-Arg-E, L-Arg-D3 or L-Arg-Palm (ABBE Labs, Farmingdale, N.Y.). In addition, a control treatment was obtained comprised of 100% white Petrolatum jelly (Unilever, Greenwich, Conn.). Aqueous solution of L-Arg at 50 mg/ml (Sigma-Aldrich, St. Louis, Mo.) concentration was used. The probe tip of a Transonic Laser Doppler Flowmeter BLF 21 Series (Transonic Systems, Ithaca, N.Y.) was implanted in an elastic headband such that the probe was lightly held on a section of skin in the middle of the subject's forehead.
[0069]Forehead Treatment
[0070]Forehead temperature was normalized prior to treatment by wearing the modified headband for five minutes. A lip balm formulation or control was then applied with cotton tipped applicator to the area of skin in contact with probe. Tissue perfusion readings were recorded every 30 seconds for 5 minutes (n=55 per treatment) beginning one minute after application.
[0071]Statistical Analysis
[0072]Mean and standard error were assessed using Statview (Abacus Concepts, Berkeley, Calif.), with comparisons made using ANOVA repeated measures and significance determined at 95% with post-hoc testing using Fisher PLSD or Scheffe F-test. All procedures and analyses were performed by blinded observers.
[0073]Results of Forehead Perfusion:
[0074]Mean, standard error, and p-values are shown in Table 2 for arginine heteromer groups and control. FIG. 6 shows effects of topically applied arginine heteromers on human forehead perfusion for arginine heteromer groups and control.
TABLE-US-00002 TABLE 2 Forehead perfusion assessment in tissue perfusion units following topical arginine heteromer treatment. Mean Std. Error P value L-Arg-D3 13.727 0.9956 p < 0.05 L-Arg-Palm 10.800 0.7188 p < 0.05 L-Arg(9) 9.198 0.4003 p < 0.05 L-Arg-E 8.016 0.5719 p < 0.05 aqueous L-Arg 9.184 0.3009 p < 0.05 (50 mg/ml) Control 4.987 0.0621
[0075]All heteromers caused statistically significant increases in perfusion with respect to the base control. L-Arg-D3 and L-Arg-Palm, which exhibited 175% and 117% increases respectively in tissue perfusion over the base control. Encouragingly, we find that all of the heteromers have greater solubility and flux across skin, while all but L-Arg-E exhibit increased perfusion after topical application. Arginine heteromers have sufficient flux across skin when applied topically to afford several therapeutic benefits related to arginine and/or the additional functionality of the heteromer.
Patent applications by Jacob M. Waugh, Mountain View, CA US
Patent applications in class TOPICAL SUN OR RADIATION SCREENING, OR TANNING PREPARATIONS
Patent applications in all subclasses TOPICAL SUN OR RADIATION SCREENING, OR TANNING PREPARATIONS
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WOODBURY - A slain officer's loved ones are on a mission to make sure that his killer does not get out of prison.
Officer Mathew Giglio was shot by John MacKenzie while responding to a burglary in West Hempstead back in 1975. The veteran cop endured an agonizing two months in the hospital before he eventually succumbed to his injuries.
Giglio's three children were joined by leaders of the Nassau PBA today in calling on the State Parole Board to keep Giglio's killer locked up. MacKenzie has served 36 years of a 25-to-life sentence.
He has maintained a spotless disciplinary record and earned college degrees while in prison. The 66-year-old convict has expressed profound regret for his actions. MacKenzie claims to have found God and he works to rehabilitate younger prisoners.
Giglio's daughter, Doreen Giglio Velardi, says MacKenzie's best work is clearly done behind bars. "Stay there and do God's work," Giglio Velardi said . "Don't come out, because you have an inclination to be violent and we can't afford to have another act of violence in this world."
Prison officials say MacKenzie's parole hearing is scheduled for the week of June 11.

subset: commoncrawl


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Bikini Bootcamp Challenge Day 8 : Stay Hydrated
Welcome to day 8 of the Bikini Bootcamp Challenge!
It is crucial to stay hydrated during your weight loss/fitness journey.
Water is a nutrient essential for life. Drinking at least 64oz of water a day is recommended. Drinking half your body weight in ounces is preferable to keep your body hydrated and healthy. The more active you are, the more water you should be drinking.
Water is an important factor in weight loss and overall good health:
- Water flushes toxins out of our vital organs.
- Drinking at least 16 oz of chilled water first thing in the morning can boost your metabolism by 24%
- Lack of water can lead to dehydration. Dehydration will make you tired, draining your energy levels.
- Drinking water helps control your between meal cravings
- Energizes your muscles
- Keeps your skin hydrated which allows us to maintain a youthful appearance
- Maintains healthy bowel function
- Replaces fluids lost during workouts
- Helps to flush lactic acid after a workout
Water also replaces 'danger' drinks that hinder the weight loss process.
Try to avoid or cut back on these beverages:
- Soda
- Fancy coffees
- Milkshakes
- Fruit drinks
- Alcohol
- Whole Milk
- Pre-sweetened Teas
Instead try infusing your water with healthy flavor!
Using fresh fruits such as citrus, berries, pineapples and melons will nicely flavor water. You can also spice up your water by using fresh herbs such as mint, sage, thyme, rosemary, basil and lavender. If you really want to infuse your water with flavor, you can experiment with different fruit and herb combinations. If you prefer your water plain, just adding a lot of ice makes water easier to drink. You can even freeze your glasses for that extra frosty chill!
**Strawberries and Mint**
Add a 1/2 cup of fresh sliced strawberries and several sprigs of mint to a 1-2 quart pitcher of fresh cold water. Refrigerate for several hours to let the flavors combine.
**Lemon and Basil**
Add 1 large sliced lemon and 1/4 cup of fresh basil leaves to a 1-2 quart pitcher of fresh cold water and refrigerate.
How often do you drink 'danger' drinks?
How much water do you drink a day?
If you don't do this already, I challenge you to cut back on danger drinks by 75% and replace with water.
If you have already eliminated 'danger' drinks, I challenge you to up your water intake.
**Once you have completed your cardio for the day, click here for the Day 8 Cardio log.
** Don't forget to update your food journal.
** Remember to fit in an extra 10 - 30 minutes of walking in addition to your daily cardio/workout.
One member who signs up for our Bikini Bootcamp Challenge and replies to 25 of the 30 daily activities will be chosen at random to WIN a $50 gift card!
Click here to sign up:
Join Me for the Bikini Bootcamp Challenge!! Win a $50 gift card and bonus prizes, too!
Join us in the Healthy Weight Loss group
How often do you drink 'danger' drinks? during dinner
How much water do you drink a day? like 2 liters
If you don't do this already, I challenge you to cut back on danger drinks by 75% and replace with water. challenge accepted!!
If you have already eliminated 'danger' drinks, I challenge you to up your water intake. I dont think you should drink much more than 2 liters a day
I've eliminated sodas, fruit drinks, fancy coffees, and sweet tea. I drink roughly 64oz of water throughout the day but am trying to increase that. I cannot stand plain water so I always add lemons and a little bit of Crystal Light. I love the above recipes and will be trying them this week :)
How often do you drink 'danger' drinks? I limit myself to 1 soda a month
How much water do you drink a day? My goal is 1/2-1gallon but I rarely reach that--DH and I were just discussing tonight that we both need to drink more water.
If you have already eliminated 'danger' drinks, I challenge you to up your water intake. I will take your challenge :)
How often do you drink 'danger' drinks? rarely
How much water do you drink a day? not nearly enough
Love this time of year when I can make sun tea.
I do commit to drinking more water because I know that benefits.
I only drink water and almond milk at home. Very rarely when I am out I will have a glass of lemonade. I am breastfeeding so I am very careful with what I drink. I do occassionally have a glass of wine. So I rarely drink 'danger' drinks. I drink water all day long to keep up my milk supply for my little guy, but I will up my intake and accept the challenge!
I am trying to cut down on soda and I love to drink lemon water.


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Banana Walnut Cake Recipe
- 1 package banana cake mix (regular size)
- 3/4 teaspoon baking powder
- 3 medium ripe bananas
- 3 eggs
- 1/2 cup water
- 1/3 cup vegetable oil
- 1-1/2 cups chopped walnuts
- 1/2 cup sugar
- 1/2 cup all-purpose flour
- 1/4 cup butter
- 1. Place first seven ingredients in a large bowl. Beat on low speed just until combined, then on medium for 2 minutes. Pour into a greased and floured 10-in. tube pan or a 13-in. x 9-in. baking pan.
- 2. In a small bowl, combine topping ingredients until crumbly; sprinkle evenly over batter. Bake at 350° for 45 minutes. Cool. Store well-wrapped in refrigerator. Yield: 16-20 servings.
Nutritional Facts
1 piece: 275 calories, 14g fat (3g saturated fat), 38mg cholesterol, 204mg sodium, 34g carbohydrate (21g sugars, 1g fiber), 4g protein.
Reviews for Banana Walnut Cake
"We love this moist cake! I've made it many times. Recently I substituted spice cake mix and a cup of canned pumpkin for the banana ingredients and it was tasty, too!"
"We love banana cake so we couldn't wait to try this! Unable to find banana cake mix we used yellow mix and added a package of banana flavored instant pudding. Combined with the bananas the flavor was perfect. Note that the topping is very generous. Great recipe!"
"Pillsbury and Duncan Hines make Banana Cake Mix. HTH"
"Who makes a banana cake mix? Thanks, Sylvia"
"This banana Walnut Cake is Yummy!!shared this to a friend and they loved it! this is one of my fave recipe and thanks for sharing :D"


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About Music Festival
The study of music has repeatedly been proven to be a stimulating and rewarding tool in the education process
Latest News
New Location for our Awards FestivalSaturday, April 30, 2016
Check the details for our 2016 Awards Concert at the Capitol Theatre! May 18th at 7pm
continue reading
Time to Think Festival!Wednesday, September 02, 2015
It's time to start thinking Festival! Music classes will begin again here in the Fall and everyone will be eager to pick up those instruments again! Take some time to start thinking about which classes you might be intersted in competing in at Festival this year! Registration will open December 1st!
Looking forward to Festival 2016!
April 25 - May 6, 2016
Strings Technical Problem has been corrected!Tuesday, January 20, 2015
Attention Strings students! The technical glitch has been repaired and registrations are now easier to enter. Sorry about the inconvenience and thank you so much for your patience!
The Kiwanis Music Festival Team
Important Dates
2016 Music Festival Dates:
April 25 - April 29, 2016 - Festival Performances for Strings, Guitar, Woodwinds, Brass, Percussion, Voice, Choral, Mixed Ensembles, Harp.
May 2 - May 6, 2016 - Festival Performances for Piano, Speech Arts and Drama.
Mid - Late February - All teachers will receive their Proofing emails to ensure that all their students are registered in the correct classes and that there are no typos.


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Baby giraffe born in Limestone zoo
LIMESTONE, Tenn. - The 'Giraffe Baby Watch' is over with the birth of a new resident of a Limestone, Tennessee zoo.
Bright's Zoo's giraffe Valerie gave birth Thursday morning. The baby boy was up and standing just a few hours after being born.
The zoo was closed after the birth, but will reopen Friday if there are no problems with mom and baby.
For now, mom and baby are staying close together in a holding area near the barn.


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With 5 littles, I don't nearly have the freedom I wish I had, but every so often I get the chance to tackle a fun craft or DIY project. While browsing some of my favorite blogs and Pinterest, of course I came across a few really fun ideas to make for babies! Some are super-easy and some may take some skill but they are all worth taking the time out of the day for a weekend project or crafting hour!
Whether it's for the nursery or a little baby style, it is always fun to be a little creative and make something for baby!
Which one will you be adding to your DIY Pinterest board?
Gauze Swaddle Blankets 1 of 7A great DIY tutorial on how you can create really great swaddle blankets -- a must-have for an infant.
See the tutorial on Dana Made It
Barn Door Baby Gate 2 of 7I can't wait for my husband to make this! Thank you Pinterest! This is much prettier to look at in the home than a plastic baby gate.
See the tutorial on Remodelaholic
Baby Tights 3 of 7Would you ever know that you can make baby tights from an old tee shirt!
See the tutorial on Made By Rae
Nursery Art 4 of 7My favorite quote for the nursery turned into art!
See the tutorial on Words of Williams
Rainy Cloud Mobile 5 of 7It may require a little skill for this one but, it is so worth it!
See the tutorial on Blog A La Cart
Simple and Sweet Garland 6 of 7This is such a sweet and simple DIY garland which would be perfect for the nursery or a first birthday party!
See the tutorial on Creature Comforts
Hanger Dividers 7 of 7Little baby clothes getting easily unorganized in the closet which is why these hangers are perfect!
See the tutorial on See Sew and Seedlings
Article Posted 4 years Ago


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New flat in punggol, walking distance to LRT .
one stop away from punggol MRT
couple / 2pax to rent $900 negotiateable
single to rent $650 negotiateable
no agent fee
rent for 6 month to 2 years.
staying with owner with 1 kid...
New Premium HDB at Waterway Terraces II block 310A Punggol Walk. Newly furnished, equipped with a home gym, a microwave oven(no cook) and is clean and beautiful. Convenient location which is 2 minutes' walk from the newly opene...
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Anhui, Fujian, Gansu, Guangdong, Guangxi, Guizhou, Henan, Hubei, Hunan, S Jiangsu, Jiangxi, S Shaanxi, S Shanxi, Sichuan, NE and SE Yunnan, Zhejiang [N Vietnam].
Physical Description
Plants annual. Stem (12--)30--80 cm tall, glabrous or sparsely retrorsely puberulent distally, branched. Leaf blade 4--8 cm wide, base broadly cuneate; primary lobes separate for at least 90% of blade radius; central lobe narrowly ovate, pinnately divided nearly to midvein, distally entire, apex long acuminate; ultimate lobules narrowly ovate or lanceolate; proximal leaves usually withered. Raceme 2--12 cm, (1 or)2--10-flowered, retrorsely puberulent; proximal bracts leaflike, distal ones lanceolate to lanceolate-subulate. Pedicels 0.4--1.2 cm; bracteoles borne proximally or near middle of pedicel, lanceolate-linear, 2.5--4.5 mm. Sepals violet or purple, abaxially sparsely puberulent; spur subulate, 0.5--2.2 cm, base 1.5--4 mm in diam.; other sepals 0.6--1.6 cm. Petals distally much widened, glabrous. Staminode limb dolabriform or ovate, 2-parted, 2-lobed, emarginate, or sometimes entire, base subtruncate or broadly cuneate. Filaments glabrous. Ovaries sparsely puberulent or subglabrous. Fl. Mar--May.
Forest margins, scrub, grassy places on slopes or by streams in hilly or low-montane regions; near sea level to 1700 m.
Molecular Biology and Genetics
Molecular Biology
Barcode data: Delphinium anthriscifolium
The following is a representative barcode sequence, the centroid of all available sequences for this species.
Statistics of barcoding coverage: Delphinium anthriscifolium
Barcode of Life Data Systems (BOLDS) Stats
Public Records: 2
Specimens with Barcodes: 2
Species With Barcodes: 1
Public Records: 2
Specimens with Barcodes: 2
Species With Barcodes: 1
EOL content is automatically assembled from many different content providers. As a result, from time to time you may find pages on EOL that are confusing.
To request an improvement, please leave a comment on the page. Thank you!


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What Are You Really Trying To Say?! Celebrity Quotes That Have Fans Confused
Sometimes celebrities make it hard to get on their team. These stars' recent comments have left their fans confused between the crazy advice, rants and shade that have come out on Twitter, in interviews and on the streets. Here's the best of the best.


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dona socorro street belisario heights, lanang Canned Fruit and vegetables
- Evaluations of Dole Stanfilco:
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... for many years about the high cost of fertilizers which had eaten into their net earnings despite the guaranteed buying price of multinational banana firms like Dole-Stanfilco ... more
On July 31, five container vans of Dole-Stanfilco banana plantation were set ablaze by NPA members at Barangay Camanlangan, New Bataan, Compostela Valley. more
... Marsman-Drysdale Group of Companies, Nader and Ebrahim Hassan Philippines, Sarang-gani Agricultural Company Inc, Nova Vista Management and Development Corporation, Dole Stanfilco ... more
The big companies like Dole, Stanfilco, Del Monte, Unifrutti, etc are still playing "big brother" roles to small growers. The big losers here are the so-called "pole vaulters," the ... more
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The uncle, Ruslan Tsarni, lives on a cul-de-sac in Montgomery Village, Md. FBI agents and Montgomery County authorities arrived shortly before 9:30 a.m. to talk to the family and take a look at the home, reported News4's Pat Collins.
Published at 2:06 PM GMT on Apr 19, 2013 | Updated at 2:52 PM GMT on Apr 19, 2013


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Here is an easy frosted fruit recipe that will not only delicious but also look beautiful and attractive. This frosted fruit recipe can be used as an appealing table centerpiece.
Total preparation time:
20 minutes to 1 hour, depending on how much you want to make.
No cooking needed.
1). Fresh fruit – use any fruit of your choice such as strawberries, apples, grapes, pears, oranges, cherries, lemons. Remember to use whole fruit, not cut ones.
2). Egg white – not beaten. Or lemon juice.
3). Sugar – use turbinado sugar to add variety.
1). First of all, wash the fruit and dry completely.
2). Put the egg white in one bowl, and the sugar in another. Do not beat egg whites.
3). Take a cooking brush, and use it to spread egg white all over the fruit one at a time. After that, roll fruit in sugar.
4). Let the fruit in it until sugar is fully crystallized on the whole fruit and make a good crust.
5). Place the fruit on parchment paper and leave it for at least a few hours in a dry area.
6). Arranging your fruit delicately on a nice place, add a few ribbons and make a great looking centerpiece for your dinner party.
Additional tips:
If you do not want to use egg white, use lemon juice on fruit as an alternative of egg white.
Apart from fruit, you can also frost mint or basil leaves to use as decoration.
It is important to avoid refrigerating the frosted fruit as humidity will melt the sugar.
You can also present the frosted fruit in a pretty box or basket to make perfect gifts at Christmas time or any special occasion.]]>
One of the great ideas for Christmas decorations is to use real Christmas trim instead of the regular plastic trim. Besides its practicality, it can play an important part in the home decoration. Therefore, the balcony is the ideal location for trims. Cranberry beads can be included between trims. Take the nice, beautiful glass bowl and put the tree trims in it. After that, add pinecones, pomegranates, apples, and other ornaments. You can place this handmade decoration on a table as a wonderful centerpiece. Moreover, you can top the glass bowl with small paper snowflakes. In fact, this can be a great alternative for a Christmas tree decoration.
Another fresh and amazing idea is to hang decorative doves on the ceiling. You can attach the beaded strings with straight pins or hot glue and put these strings in the mouth of doves as if they are flying in to decorate the space. The strings should be long enough to cover the end over the limb of the Christmas tree. For the birds' suspension and pushpins for security, use white strings. After that, place the doves at different distances to form the tree decoration. Moreover, along with the variety of Christmas ornaments on the tree, attach some other ornaments to the feet of doves.
In addition, one of the most distinctive Christmas decoration ideas is a bird nest along with well-designed tiny eggs. You can include a mommy bird on the nest to show more comfortable and warm atmosphere in the house. Certainly, the kids will have much fun while searching for the bird's eggs, rearranging the eggs, rearranging the birds, and trying to make the birds fly. In fact, if you explore the decorative Christmas tree, it will become a special Christmas treat for kids.]]>
Here are some design styles and some of their features that you may consider in planning your kitchen.
An attractive design element that complements the gray tones and pewter hardware is stainless steel. If you want to match your countertop with wall color, you can paint steel countertop support brackets in the off-white and neutral colors.
Moreover, color accents in grayed tones or sun-baked colors with predominately white, off-white or neutral based colors look great. Surface selections that are most appropriate are ceramic tile, soapstone, slate, and wood in a matte finish with a natural and heavy look. Among hardware choices, you can use pewter, rustic metals, wood, and wrought iron. In addition, wood finishes in pine, oak, and walnut are the most popular wood types for these styles.
Missions/Arts and crafts:
This style basically provides metal finishes. Any solid built, metal bracket can be used to provide a beautiful support for your countertop. In this style, you need to go for warm colors, such as soft green, golden yellow, natural dyes, and earth tones.
Among surface selections, natural stone, multi-colored porcelain pottery, and the matte finish of rough earthenware materials are perfect choices. Any brushed finish or metal, except brass will work well with this design. Items constructed of oak are mainly used in mission inspired designs, whereas objects constructed of cherry are often used in arts and crafts designs.]]>
Here are some tips that should be remembered when deciding over colors:
1). When using many colors in one single room, ensure to use a color at least three times in the same room. Different shades and tints of that color can also be used. For example, pillows, tablecloth, and curtains can be of the same color. This will harmonize the room decoration, and will help in avoiding the 'too much' and 'confused' look.
2). Use warm colors such as reds, oranges, and yellows to fill the space. These colors and their shades are soothing and warm, and they tend to grab the eyes and fill the space.
3). Use cool colors such as greens, blues, and violets to give an illusion of more and open space.
4). Use pale pinks for a serene and comforting look. As the pink color gets closer to red, it becomes more energetic.
5). For giving an illusion of height, use vertical stripes on walls and curtains.
6). Use horizontal stripes on walls and curtains to give an illusion of length.
7). Use light color on the walls and ceilings to make the room look larger and more roomy.
8). Avoid using contradicting colors and themes. When you need to make your room look larger and want to use cool colors to achieve it then select a theme which best complements the cool colors.
9). If same colored carpet, sofa and other upholstery give a monotonous look then use colorful cushions and wall-hangings. This will not only break the monotony but also give the room more attractive look.
10). If you don't want to use any color in the room then you can use black, white, and/or different shades of grays.]]>
Here are some useful tips that can help you in decorating a small studio apartment.
Choose wisely and edit ruthlessly:
The most fundamental way of decorating a small studio apartment beautifully is by ensuring that it does not seem small and cluttered. Ensuring to bring in what is extremely essential and phasing out all that is not necessary is the best way to clear the clutter out. In a small apartment, there is no way to accommodate stuff for mere aesthetics. Utility should be first your priority.
Create a well-defined and adequate storage space:
When picking and selecting as much as you do, it is necessary to have an adequately large concealed storage space to hold all the stuff that you wont throw away. This storage space should be capacious and well-maintained.
Make specific areas and stick to a single flowing theme:
It seems and feels good when you have a single flowing theme throughout your small studio apartment. Do not complicate things by overdoing the design aspect. Try to keep it single and simple.
Moreover, create a well defined areas and rooms to make sure that one does not impinge on the other. This will make it easy for you while shopping for furnishings as you will have a clear idea about what to buy for each area and room.
Lighting and dividers:
The space of the apartment can be demarcated by using dividers. Although it is a good idea to use thin glass, you can also try wood. Selecting the glass or wood totally depends on your need and taste. Use of right lighting elicits the beauty of the apartment and makes it look less crammed.
Purchase smart, space-conscious furniture:
In this modern era, furniture is also programmed to multi-purpose. It is a wise decision to invest in something that saves on space. You can do it in many ways as the multi-purpose furniture ranges from a sofa set that doubles up as a bed to a smaller bathtub that fits easily into a corner. You can always find a good deal on smart stuff if you are willing enough to go the extra yard and search thoroughly.
Remember that it is not an easy task to design a small studio apartment into a cozy little hub. The renovation needs imagination, patience, and ability to be extremely creative. These simple steps will surely give you an idea how to get over your small scale designing wretchedness.]]>
Following are a few important tips and ideas that can be used to decorate the reunion party in order to make it enjoyable and memorable.
For a family reunion party, you need to make a banner to welcome the guests in the party. There are a number of ways in which you can decorate the banner. You can use colorful ribbons and flower petals to decorate it.
If you are arranging the party for a particular event, then you need to make decorations accordingly. You can hang related photos and can use balloons and flowers for additional decorations. An important aspect in reunion party décor is the table decoration. Decorate it by having a colorful and decent centerpiece, which best complement the rest of your party décor.
For a school reunion party, you need to have photos of all students so that you can hang them in a particular corner. You can also use different materials to make photo charts. One idea is to make name tags of various shapes for all invited guests. This will eliminate the need to ask names of each others.
You also need to decorate the grand entrance. You may arrange to leave balloons filled with helium and glitter. While decorating the party venue, make sure that all decorations should be best complement with each other.]]>
A number of brides feel too much burden on their shoulders about the wedding decorations that they forget to enjoy the process of wedding decorations. Of course, you do not want the same to be your experience. The good news is that there are many unique wedding reception ideas that will surely help you in creating your dream wedding.
Here are some of the wedding reception decorating ideas that you can use to plan the decorating scheme for your wedding reception.
Using these ideas will assure you to have a wedding reception that is not only beautiful and appealing but also unique and memorable.]]>
Among many other baby shower themes, Winnie the Pooh is an all time favorite theme. This reminds us of a wonderful time of our childhood. Therefore, it is a good idea to use this theme for your next baby shower theme, and everybody will surely enjoy being part of your baby shower party. Here are some of the Pooh baby shower decorations that will help you in decorating your party.
Baby shower invitations:
Although Winnie the Pooh invitations are easily available online or at your local party stores, however, you can show your own creativity by sketching out your own copies from construction paper to make interesting baby shower invitations.
When it comes to decorating the party, you can change your party venue into the Hundred Acre Wood by making trees, a garden, and a picket fence out of large art paper. You can even make the cutouts of Tigger, Eeyore, Piglet, and Kanga.
The traditional party decorating items such as balloons and streamers can easily be found in Winnie the Pooh theme. If you want to use Winnie the Pooh balloons, it would be great to use white and tan, which is the Pooh color, for the streamers. Also, you can decorate the room with the Pooh themed little knick knacks and a few honey pots.
Use these decoration ideas to make your baby shower party fun, enjoyable, and memorable.]]>
Mirror water fountain can be seen in many large and well organized companies. A number of offices use mirror water fountain to decorate the wall over which the logo is being mentioned. This is an appealing way to decorate the company's logo. The slate and the mirror are the very good options; however, the use of mirror is getting more popularity.
The surface options contain not only the clear glass but also the slate, silver, or blue mirror. Whereas the trimming options contain the copper, stainless steel, and powder coating. These fountains have the re-circulating water pump system which gives the very soothing and relaxing water display. Although this fountain looks magnificent however it is quite expensive and many people cannot afford it.
Popular varieties of mirror wall fountains include Serrano, Teton, Summit falls, Sunrise Springs, Cascade Springs, and Inspiration falls. Although many people think that these fountains have a very high cost however, many people opt for these mirror wall fountains.
In contemporary style homes, almost all of them have the mirror wall fountains in some corner or the other. Many traditional designers suggest to have these fountains at the entrance gate of the house. However, you can implement it anywhere you want in the home interior, especially in the living room and the dining room. They can change any home into a soothing and calming atmosphere as the natural sound of water dribbling down a water fountain surface is relaxing and calm the mind as well as body.]]>
You can change the whole look of the house by just changing the rugs and by thoroughly cleaning the house. It is better to start work a month before Christmas in order to change the whole look. You can easily make your home beautifully decorated by using a creativity, planning, and color coordination with furniture and accessories. Get rid of clutter or unnecessary things from the house to have a more space. Rearrange the furniture to improve the appearance of the place.
If you think that your sofa is old fashioned and look dull and boring then you can change its covers to have a whole new look. Using some laced or showy curtains in your living space and placing a beautiful rug in the sitting area can change the room décor. You can also have a specially designed Christmas rugs to decorate your home. However, if you do not want to use the Christmas featured rugs in your home, then you can use the colors of Christmas either in a monotone or a different combination of green, red, and white.
Consider decorating your living room and the dining room the most as this is these are the places where guests will be entertained during Christmas. Pay special attention to decorate the Christmas tree as it the focal point of the Christmas decorations. Besides this, hang different shapes of mistletoes and bells, snowmen, and Santa around the house. Create a welcoming sight at the door by hanging a big Christmas wreath with hollies, bows, and ribbons.
Decorate your dining table by placing an attractive centerpiece on it. You can make the centerpiece of your own by arranging the fresh or artificial flowers and greens. You can also create a wonderful centerpiece by having Christmas candles decorated with flowers. Place the Christmas sweets or chocolates in various shapes such as stars, Christmas trees, snowmen, Santa's, fruits, and flowers. Also, place the fancy gifts near the Christmas tree for children and all the small guests.]]>


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looking forward to galaxy!!
So can we all just stop asking when it will be released and wait to see what they say then. Even though this is just a rumor I'd say its more than likely.
looking forward to galaxy!!
Mario strikers charged thing is... 154721 335104
Now what do i do??
mario kart wii will be good
PS3 now, sorry Wii. You gather dust.
ehm. whens E3? and better yet, when can/will people start talking about happened there openly?
July 11 - 13
I'm more excited about Mario Kart than SSBB.. dunno why
Last edited by Celestial; 06-05-2007 at 07:04 AM.
360 GT: LostCelestial
PSN ID: AerialSpirit
Still quite a while to wait to find out this information. I'm curious on Disaster, Project HAMMER ,and Kirby's status.
My Wifi games (ASK ME FOR MY CODES)
Rock Band 2,Call of Duty W@W,Mario Kart,Nights,Tetris Party,Dr.Mario,WWE Smackdown VS Raw 09,Battalion Wars 2,Mario Strikers,Smash Bros Brawl,Quantum of Solace,Medal of Honor Heroes,Excitebots,The Conduit,and Call of Duty Modern Warfare
man. ime sooo AMPED about e3...
i cant wait to just go on ign one day after school andget flooded by information about all the major nintendo games..i think its obvious that there going to givethe release dates.. do you think nintendo will announce any new projects for the wii other than mario kart.. or any other developer
i just wanna see some more of SSBB footage, and some Mario Kart footage too, galaxy, meh, its cool and all but that footage would be boring compared to fast action games like mario kart/SSBB. i think im more hyped for smash then mario kart, mario kart is a game of luck imo, or more so luck then smash is. I am good @ kart tho, im ok at smash.
SSBB will be awesome! and mario kart will be cool too!
Thanks To Dan.Skater For The Awesome Sig!
Imo, it was a given that they were going to release all this info. Along with Starfox Wii, Kirby Wii, Pikmin 3 and other future plans.
Not to fit a mold,Not to join a trend,Not to follow a crowd


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3 Reviews
Great but expensive for the little tube
Posted 3/30/2015 by judith
Great product but expensive for the half size. I always get the 400 ml which you get more bang for the buck. SkinCareRX, please carry the 400 ml
Best product for hard water for face and body
Posted 3/30/2015 by judith
I lived in London for a while and the water out there is hard with chemicals. This was my go-to body wash for my face and body. My entire family is now hooked on it. Love it...
Gentle for face and body
Posted 6/9/2011 by Minx
I got this for my husband, who suffers from eczema and dry skin. He loves it - it's simple and effective and not too 'girly'. His skin is softer and smoother. I've been using it for a face wash and I really like it, too. It cleans thoroughly without stripping my skin. This is a great all-over cleansing product. It's mild enough to use on sensitive, dry skin but effective enough to get the job done.


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2933-3013 North Yarbrough Drive
Commute to Downtown El Paso
Some errands can be accomplished on foot.
About your score
2933-3013 North Yarbrough Drive has a Walk Score of 60 out of 100. This location is Somewhat Walkable so some errands can be accomplished on foot.
This location is in the Album neighborhood in El Paso. Nearby parks include Eastwood Junior High School Track and Field, Eastwood Park and Eastwood Junior High School Baseball Field.
Explore how far you can travel by car, bus, bike and foot from 2933-3013 North Yarbrough Drive.
View all Album apartments on a map.
Search for homes in El Paso or find a El Paso real estate agent who knows walkable neighborhoods. Links will open on our partner site Redfin.com.
2933-3013 North Yarbrough Drive is in the Album neighborhood. Album is the 73rd most walkable neighborhood in El Paso with a neighborhood Walk Score of 49.
Moving to El Paso from another city? View our moving to El Paso guide.


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Through a unified approach and stakeholder consensus, ORCGA fulfills its motto of "Working Together for a Safer Ontario"
We are a growing organization with over 520 member/sponsor organizations representing 19 stakeholder groups.
For over a decade these stakeholder groups have been active in promoting "Call Before You Dig" and damager prevention practices. The ORCGA provides a single unified voice that represents the damage prevention community in the province.
Calling all Locators, be part of the first ever ORCGA Fall Utility Locate Rodeo!
The ORCGA Locate Rodeo will be held October 27 – 28, 2016 at the Nottawasaga Inn Convention Centre and Golf Resort.
Click HERE for Volunteer Registration.
Click HERE for Competitor Registration.
For more information, click HERE.
The ORCGA 11th Annual Golf Tournament was a huge success.
Click on this link to view pictures from this great day!


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The day has come.
Donald Trump is rallying in San Diego at the Convention Center at 2 p.m. (doors open at 11 a.m.). The San Diego Free Press will be live blogging today's events. We'll be pulling pictures and updates from people on the front lines who use the hashtag #NeverTrumpSD or you can send them directly to firstname.lastname@example.com.
Here's what you need to know right now, plus a list of anti-Trump protests throughout the day: [Read more…]


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Outside Macelleria restaurant in Manhattan, the day of the 2006 World Cup final between Italy and France. July 9, 2006. Photograph by Erika Quattrocchi.
Send VF.com your Soccer Shots! Fair Play will post a soccer photograph each weekday through this summer's World Cup.
Email photos with caption and credit information to email@example.com
Vanity FairVanity Fair features in-depth reporting, gripping narratives, and world-class photography, plus heaping doses of Oscar-blogging, royal-watching, and assorted guilty pleasures.


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Fix Image Edit in Lister App
This project was successfully completed by rinsadsl for $125 USD in a day.Get free quotes for a project like this
Project Budget$125 USD
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The images are retrieved and displayed for the user to review. The user needs to have the ability to change the image, or remove the image - and it needs to update to the appropriate tables to display correctly on the website.
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- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


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Every year J.D. Power and Associates releases a study that names the most dependable three-year-old cars on the market. This year's results include some surprises but also reinforce some long-held beliefs regarding brands that are known to be exceptionally reliable.
Some of the most common complaints about the cars did not have to do with mechanical failures or poor build quality, but were frustrations with wireless connections, navigation, and voice-recognition software.
Technology has infiltrated our cars at a pace never before seen in the history of the auto industry, but automakers haven't yet figured out how to seamlessly integrate it into the lives of their customers.
If technology is our biggest complaint, though, I don't think we really have much to complain about.


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gets a new look !
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A Feature film by Marcel Carné
Produced by Films Sacha Gordine
Release in France : 18/02/1950
Henri Chatelard is well in his forties, owns a restaurant and a cinema in the city, and appreciate women. When he meets Marie, a 18ish stronghead who just lost her father in a small fishermen village, it is not clear who is the hunter and who is the prey.
Source : IMDb.
Recovering from his disastrous experience with the never-completed La Fleur de L'Age, French filmmaker Marcel Carne proved he hadn't lost his touch with La Marie du Port. Played by Nicole Courcel, the eponymous Marie is the younger sister of Odile (Blanchette Burnoy). Odile in turn is the mistress of been-there-done-that Chatelard (Jean Gabin). Upon meeting Marie, Chatelard's cynicism melts away. Still, he merely toys with the girl's affections--at least until he discovers that Odile is carrying on an affair with Marie's boyfriend. Chatelard stops Marie from committing suicide, and for the first time in his life really means it when he pledges his undying devotion. Like many French films of the era, La Marie du Port was but a shadow of its former self when the American censors got through with it.
Hal Erickson, Rovi
Louis Chavance, Georges Ribemont-Dessaignes, Marcel Carné


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Denim Done White: How Celebs Are Wearing White Jeans
White denim is making a major return to the sartorial spotlight with a little help from the celeb set.Read more
ellen degeneres
Denim Done White: How Celebs Are Wearing White Jeans
White denim is making a major return to the sartorial spotlight with a little help from the celeb set.Read more
2016 People's Choice Awards Kicks Off Red Carpet Season
The new year doesn't officially begin until the first award show.Read more
WATCH: Rebel Wilson Proves the Pain of High Heels on The Ellen Show
The struggle is real.Read more
See All the Best Celebrity Costumes from Halloween 2015
Another Halloween has come and gone, so now all we're left with are the haunting memories of celeb costumes.Read more
Ellen DeGeneres Adds Footwear to Her ED Lifestyle Brand
Some shoes are already on sale.Read more
Link Buzz: Kelly Osbourne Has Some Words for Giuliana Rancic, Emma Roberts Is Unretouched in New Aerie Campaign
Tell us how you really feel, Kelz.Read more
Stars Make a Splash on the 2015 Teen Choice Awards Blue Carpet
Get ready to ride the wave of fashions from this year's show.Read more
ED by Ellen DeGeneres Lifestyle Brand Debuts Online
It's finally here!Read more
This Guy Can Make Himself Look Exactly Like Every Celebrity You Wish You Looked Like
How much to get him to make us look like Beyoncé?Read more
The Stars Come Out for the 2014 People's Choice Awards
The people have spoken and the stars hit the red carpet last night to celebrate.Read more
13 Things (Besides Kim Kardashian's Butt) That Almost Broke the Internet in 2014
We present 13 things that made the Internet lose its collective mind in 2014.Read more
Foolproof First Date Outfits Inspired by Our Favorite Celebrity Couples
Stumped on what to wear on a first date? These red carpet regulars have you covered.Read more
Introducing Ellen DeGeneres: Lifestyle Brand
The talk show hostess is delving into retail, launching a homeware, apparel and pet accessories label.Read more
Lady Gaga Fame-Whores Her Puppy, Channels Cruella de Vil
Karl Lagerfeld shook the earth, moon, and stars when he introduced humanity to his new kitten, Choupette. As The Kaiser loves to say, his little furball is the most famous of all the cats — and that isn't an exaggeration. Magazines want to take her picture and the Internet wants to Tweet at her because […]Read more
Lindsay Lohan Flaked Out on Ellen
Lindsay Lohan was supposed to jet out of Honolulu after her Hawaiian vacation and get to New York in time to tape a segment on the Ellen Degeneres Show to promote her latest project, a spread for Playboy. But LiLo missed her flight out of Hawaii and the Ellen show, wrapping up taping for the […]Read more
Jennifer Aniston Bobs Her Hair; ANTM Premieres Tonight!
Also: Justin Bieber ditches his famous bowl cut and Lady Gaga complains about being famousRead more


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Grow without giving away your company.
Our funding helps entrepreneurs get to the next level without
equity dilution, board control, or personal guarantees.
When you grow with Lighter Capital, you remain in full control of your company. We don't take equity or ask you to make personal guarantees. And we don't take a seat on your board or make you write a fat check if you're having a down month.
It's your company.
We're here to help accelerate your growth – on your terms.
A community of entrepreneurs
When you become part of the Lighter Capital portfolio, you have access to a deep bench of entrepreneurs just like you.
- 110 SaaS company CEOs
- 47 Additional Co-Founders
- 96 VPs – Sales & Marketing
- 129 Expert Mentors
At key times during our growth, Lighter Capital got us the funding we needed fast, allowing us to invest in the business, and not be distracted by fundraising.
John Stewart, CEO
A side-by-side comparison
|Lighter Capital
|VC & Angels
Expected Annual Return15-30%
Personal GuaranteesNone
|2-6 months
Fundraising Period2 weeks or less
|3-9 months
|Warrants / None
|Own 20-40% of your company + board seat
Personal Credit ScoreDoes not affect credit
|Does not affect credit
We work with
The funding choice of 110+ technology startups
"I tried to get money from banks, but there were no hard assets to lend against or they wanted too much control. That's when Lighter Capital came in."
Rupert Mayer, IPfolio
"We were used to bootstrapping, and I liked that this type of financing would allow us to bootstrap our way out of any difficulty. If we had done a normal debt—with a fixed repayment amount—financing would have been more risky."
David Lischner, Valant
"The more cash receipts we had, the faster we could pay. So the incentives were completely aligned. The better we did, the better Lighter Capital did."
Max Rudman, SteelBrick


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Official Website of the New York City Department of Parks & Recreation
Photo Gallery > General Gallery > Greenbelt Native Plant Center Tour Album > Greenbelt Native Plant Center
Back to Album Description
Date: July 15, 2011
Was this information helpful?
Thank you for your feedback.
(Optional) Please tell us how we can make this page more helpful.If you need a response, please use the Contact the Commissioner form instead.


text:
The week of MLB winter meetings have come and gone, and there have been major shockers so far. Everyone figured Albert Pujols would either end up in St. Louis or Miami, but he ended up as a member of the Angels.
That was just one of the many stories throughout the meetings, which turned the Los Angeles Angels of Anaheim into a star-studded team. The meetings were great for Miami as well, who snagged a myriad of top-level free agents for themselves.
Heading further into free agency, what is each team's juiciest storyline?


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Today «ChernomorNeft-Gaz» is among top ten oil companies of the country. It comprises 21 producing enterprises, 2 oil refineries and its own distribution system of gasoline filling stations, located in 14 regions of Russia and CIS. The geography of "ChernomorNeft-Gaz" covers KhMAO, YNAO,the Tomsk Region, the Ulyanovsk Region, the Penza Region, the Volgograd Region, the Bryansk Region, the Saratov Region, the Kirov Region, the Orenburg Region, the Krasnodar Territory, the Republic of Udmurtia and the Republic of Belarus. The headquarters of the Company is situated in Moscow. More than 170 oil-gas fields are being under development. "ChernomorNeft-Gaz" NEP exceeds 600 mln.tons. Today the Company produces 14,2 mln. tons. The bulk of refining comprises 7,4 mln.tons.The Company has an up-to-date crude oil terminal with the volume of output up to 7 mln tons per year. The terminal is located in the Bryansk Region. The staff of the Company counts 20 thousands people.
2016 http://chernomorka.dm0.ru/ © All Rights Reserved


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Daily Archives: August 6, 2006
Daily Observations
After spending the better part of the day inside, I left for a walk in the late afternoon. I went up to Indian River near the trail head then followed the river down to Totem Park. The water was fairly high, so I could not walk the river, but I did … Continue reading
Interesting Eagle
I saw this eagle at Totem Park today. I do not recall seeing plumage quite like this before. I am uncertain whether this is a fairly typical phase of transition between immature and mature plumages, or if this bird is … Continue reading
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Hotels in Faridabad, India
Search & Compare Faridabad Hotels
Get Secret Prices on select hotels
These prices aren't available to everyone.
Trending now in Faridabad
- Most bookedPark Plaza Faridabad
204 people looked at this hotel in the last hour
Most recent review
"Thank you to all the staff at Park Plaza, Faridabad for making me so very welcome it was a pleasure to stay at your hotel. Excellent service from the moment I arrived until I left. Everybody was so helpful & friendly. Food was excellent & plenty to choose from regardless of what your tastes ar..."
A Traveller, Jun 2016, GB
56 people looked at this hotel in the last hour
Most recent review
"Great stay. My son had good fun at pottery classes and enjoyed Kid's zone. They have in house activities to keep you busy. Would love to go back again for relaxation."
A Traveller, Feb 2016, IN
17 people looked at this hotel in the last hour
Most recent review
"Things I really liked: the helpful staff, the clean and well-maintained facilities and rooms, the quiet environs and the well-appointed rooms. Things that need improvement: the food in the restaurant is overpriced and the quality is not too great, especially for the price. The regional breakfast..."
A Traveller, Nov 2015, GB
14 people looked at this hotel in the last hour
Most recent review
"It was Good However we just stayed for One Night En route to Taj Mahal."
A Traveller, Jan 2016, US
11 people looked at this hotel in the last hour
11 people looked at this hotel in the last hour
Most recent review
"With a mixup in the reservation they accommodated us with an upgraded suite room. Staff was extremely courteous and the restaurant was great. Newspaper everyday, bottled waters everyday. Price of a local high end business hotel in the industrial city of Faridabad but quality of an American 4 star."
A Traveller, Feb 2016, US
9 people looked at this hotel in the last hour
8 people looked at this hotel in the last hour
Most recent review
"This hotel is quite convenient because it is near to a metro station. The staffs are friendly and helpful. The foods in the restaurant are quite tasty "
A Traveller, Oct 2016, US
4 people looked at this hotel in the last hour
3 people looked at this hotel in the last hour
Map of Faridabad hotels
Best hotels in Faridabad
If you are looking for Faridabad hotels in a particular area, you can use the search feature at the top of the page to search by neighborhood, landmark, address or zip code, or you can search by using the built-in map feature. You can also browse hotels in Faridabad by type, amenities, and star-rating so that you can find the best hotel. Currently, top rated hotels in Faridabad are:
- OYO Rooms Faridabad
- Hotel Delite Grand
- Vivanta by Taj - Surajkund, NCR
- Park Plaza Faridabad
- Vibe By The LaLiT Traveller
The location of your Faridabad hotel is important. If you are traveling to Faridabad, &StateorCountry for business, you may want to consider getting a hotel close to the airport or near your meeting venue. By doing so, you can really cut down on transportation costs and time. You may also want to book a hotel that offers free wifi just in case you need to get some work done.
If you are traveling for vacation, figure out which attractions or landmarks you want to see and book a hotel that is within close proximity. Although hotels near attractions might cost a little more, you may find that spending those extra few dollars is worth the convenience. You can even find hotels that align with your interests. For example, if you are looking for a relaxing vacation, a spa hotel may be the perfect choice for you.
You'll also want to determine which type of accommodations will suit your needs before booking a hotel in Faridabad. If you're traveling with the kiddos, a family friendly hotel will offer larger rooms and more sleeping arrangements. For those traveling for an extended period of time, booking a hotel suite with a kitchenette is a smart move and will feel a little more like home. If you are budget conscience and just need a place to rest your head, a hostel or motel may be all you need.
If you are looking to score the best discounts and deals, use the filter to sort by price from low to high. You can book a hotel in Faridabad for as low as $35 per night. If you are looking to cut down on expenses, look for hotels that include free breakfast and parking. Some hotels even offer free shuttle service to and from nearby places. You can also sort by star rating, proximity, and guest rating.
Before you book, check out user reviews. Hotels.com has 167 reviews in Faridabad. We show reviews from Expedia and TripAdvisor so you know that you are reading genuine, reliable reviews. Be sure to download the Hotels.com app so you can book your reservations on the go, view amenities, and save the hotels you want to view and compare later.


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as seen in a shop window in Little Italy
nyc humor type graphics
Well done Susan! Nothing surprises me when it comes to the public stupidity that poor mis-guided Paris ezpresses. Oh, well!
thanks Christine. so true…..:)
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This website contains affiliate links. Any purchases through affiliate links will provide me with the income necessary to keep this site available at no extra cost to you.
Add this project to your Ravelry favorites HERE.
To print or convert to PDF click the green "Print Friendly" button below the pattern.
Daisies Filet Afghan
designed by Kim Guzman © Jun. 1999
Email to firstname.lastname@example.com
Please read my Terms of Use
Technique: Filet Crochet
- Size D/3/3.25m crochet hook
- Approximately 3750 yds Red Heart Lustersheen used in sample
- Yarn needle (for weaving ends)
Finished Size
approx. 46″ x 52″
A swatch worked in Open Mesh for 21 blocks across and 21 blocks high measures a 6″ square
Basic Filet
Each solid square is equal to 3 dc. Each open square is equal to (1 dc, ch 1, 1 dc). The dc at the end of each square also counts as the first dc of the next square. For example, a solid square followed by an open square is 3 dc, ch 1, 1 dc. Solid squares count as "solid mesh" and open squares count as "open mesh".
Tip: When finished with one ball/cone of yarn, attach the next ball/cone only at the beginning or ending of a row to aid in the weaving of the loose end.
Row 1: Ch 323, dc in fourth ch from hook and in each ch across, turn–321 dc.
Row 2: Ch 2 (counts as first dc on this and each remaining row), sk first st, dc in each remaining st across, turn–321 dc.
Row 3: Ch 2, sk first st, dc in each of next 4 sts, *ch 1, sk 1 st, dc in next st, rep from * to last 5 sts, dc in each of last 5 sts, turn.
Following the diagrams (two included) and the Filet Stitch Key, continue until all rows are completed. Fasten off. Weave in all ends securely.
This Print Friendly button will work for about 99.999% of the internet public. If you are part of the .001%, please feel free to use any other PDF software, print to paper, copy/paste to a document or any other method you prefer to use. You certainly don't have to use my preferred method. I have been designing and writing patterns for over 20 years. All of my designs have been created originally by me. Any similarities to any other designs are purely coincidence.


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Car Wash Soaps
If you want the highest quality car wash soaps at the lowest prices, then you have come to the right place. Here at Detailing.com we give you the best car wash products with our lowest price guarantee. Check the rest of the site for more information on the kinds of deals you can score.
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Give Yourself the Gift of Boozy Ice Pops This Summer
Popsicles are great. Popsicles with rum? Even better.
This Spicy-Sweet Chile Mango Sundae Is Summer in a Glass
What's the move when it's 100 degrees out and the last thing you want is full-dairy ice cream? This chile mango sundae, of course.
18 Mango Recipes That Bring the Tropics to You
Don't live on a remote island? Let these 18 mango recipes—for salads, desserts, drinks, and more—transport you there, even if only for a little while.
Thai Steak and Noodle Salad
This is no simple salad: It's a multicourse meal on a plate. Its dramatic presentation is part of the allure.
28 Tropical Fruit Recipes that are (Almost) as Good as the Beach
So you can't hop a flight to the Caribbean. At least you can pretend with these recipes for mangoes, pineapples, papayas, and more.
Tropical Carrot, Ginger, and Turmeric Smoothie
A pinch of salt makes everything taste better, including savory smoothies.
Tom Collins Bar
Aside from banana, we can't think of a fruit that wouldn't be good in this drink.
Rice Pudding with Ginger, Amaranth, and Mango
Ginger adds unexpected heat and zing to this coconut rice pudding; the crunchy topping lends a welcome texture contrast.
Chicken and Green Papaya Salad
The difference between this papaya salad and a Thai-style one comes down to spice and sugar, says chef and author David Tanis. The Vietnamese one is sweeter and less hot. Have all the ingredients assembled, but dress the salad just before serving.


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Magic: The Gathering - Tactics
Game Overview
Magic: The Gathering - Tactics is a strategy game developed by Sony Online Entertainment and released on Microsoft Windows.
Similar Games
- Sid Meier's Civilization Revolution (0.79m)
- Tom Clancy's EndWar (0.65m)
- XCOM: Enemy Unknown (0.60m)
- R.U.S.E. (0.51m)
- Command & Conquer: Red Alert 3 Ultimate Edition (0.37m)
- Angry Birds Star Wars (0.33m)
- Dai-2-Ji Super Robot Taisen OG (0.30m)
- Plants vs. Zombies (0.19m)
- Nobunaga no Yabou: Souzou (0.19m)
- Stormrise (0.17m)
- Nobunaga no Yabou: Tendou (0.13m)
- Record of Agarest War Zero (0.12m)
- Romance of the Three Kingdoms XII (0.09m)
- Tears to Tiara: Garland of the Earth (0.08m)
- Super Robot Taisen OG Saga: Masou Kishin III - Pride of Justice (0.07m)
- Nobunaga no Yabou: Tendou with Power-Up Kit (0.07m)
- Super Robot Wars OG Saga Masou Kishin F: Coffin of the End (0.06m)
- The History Channel: Great Battles - Medieval (0.05m)
- Fritz Chess (0.04m)
- Tears to Tiara Anecdotes: The Secret of Avalon (0.04m)
External Links
- Magic: The Gathering - Tactics on Vandal
|View all


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Welcome to Pantheon Technology Consulting...
...and our website. It's always going to be a work-in-progress because we're always up to something good. We specialize in Information Technology (IT) consulting services, specifically helping organizations like yours identify your technology needs, deliver great solutions for these needs and once that's done correctly, find other improvements to make. The cycle repeats itself. We're based in the Philadelphia suburbs but in today's day and age, we can serve any client anywhere. Please browse for more details by following all of the links below.
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