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Dilaforette's lead drug candidate, sevuparin, is currently being tested in a multi-center, double-blind, placebo-controlled phase II study, enrolling hospitalized Sickle-Cell Disease (SCD) patients experiencing vaso-occlusive crises (VOC).
SCD is an orphan disease with disabling and potentially fatal outcomes and with a large unmet medical need in both the developed and developing world. In the US and in Europe, it is estimated that close to 100,000 and 35,000 patients, respectively, are diagnosed with this hereditary disease. There is also an even larger patient pool in the Middle East and North Africa (MENA) region. SCD patients undergo on average one VOC per year. This acute complication is caused by sickled blood cells obstructing the blood flow to vital organs leading to ischemia and often severe pain. Long-term, SCD patients are at risk of organ damage and premature death.
Sevuparin is Dilaforette's innovative, disease-modifying polysaccharide drug, with extensive world-wide IP protection. Dilaforette has received Orphan Drug Designation (ODD) in both US and EU for sevuparin in SCD.
Sevuparin acts like an anti-adhesive, blocking the key adhesion receptors involved in the events leading up to a VOC. Based on its mechanism of action and excellent tolerability, sevuparin has the potential to become the best-in-class treatment of painful crisis in SCD patients.
Both preclinical data and clinical studies support that sevuparin can have rapid and clinically relevant effects on prevention and resolution of the microvascular obstructions. Dilaforette intends to initially develop sevuparin for the acute treatment of Vaso-Occlusive Crises (VOCs) starting with the ongoing phase II study in hospitalized SCD patients, where sevuparin is administrated intravenously. In parallel, a subcutaneous formulation is being developed for early self-treatment in the home setting. Such an early treatment has the potential to decrease the number of patients going into full-blown VOCs and requiring hospital care. Subcutaneous sevuparin could thus be key in normalizing the SCD patients' daily lifes.
There is a large need for new therapies addressing the cause and not just the symptoms of vaso-occlusion in SCD patients, as there currently is none available. The only treatment approved for SCD patients is hydroxyurea (a.k.a. hydroxycarbamide), indicated for reducing the frequency of VOCs in SCD patients with recurrent VOCs. However, treatment with hydroxyurea has no effect on neither the pain intensity nor the severity of the acute VOC for the patient.
Based on its mechanism of action and excellent tolerability, sevuparin has the potential to become the best-in-class treatment for SCD. Ultimately, it is believed that sevuparin can be self-administered to abort developing VOCs.


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The DTM fascinates motorsport fans for more than 30 years now and is regarded as one of the world's toughest and most hard-fought racing series.
Audi, BMW and Mercedes-Benz each send eight cars to the grid in the 2016 season, and every car is occupied by top-class drivers. Each of the 24 drivers is capable of fighting for victory – this in itself is unique worldwide. The performance parity is so close that often only hundredths or even thousandths of a second prove crucial. Last year, there were 13 different winners in the 18 races. Six of these drove an Audi RS 5 DTM.
V8 quattro, TT, A4, RS 5: the brand with the four rings has won the prestigious drivers title at least once with every type of car that Audi has fielded in the DTM so far – most recently in 2013 with Mike Rockenfeller as first driver of an RS model from Audi Sport. After the Audi RS 5 DTM proved the car to beat last year with ten victories in 18 races, a clear goal has been defined for 2016: The start number 1, the Champion's symbol, should return to Neuburg. Audi also has both the manufacturers and team titles firmly in its sights.
06.05.–08.05. Hockenheim (D)
20.05.–22.05. Spielberg (A)
03.06.–05.06. Lausitzring (D)
24.06.–26.06. Norisring (D)
15.07.– 17.07. Zandvoort (NL)
19.08.–21.08. Moscow (RUS)
09.09.–11.09. Nürburgring (D)
23.09.–25/09. Budapest (H)
14.10.– 16.10. Hockenheim (D)

subset: commoncrawl


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J. Eduardo Rame
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Attending, Cardiac Catherization Laboratory, Hospital of the University of Pennsylvania
Attending, Heart Failure, Mechanical Assist, and Cardiac Transplantation Program, Hospital of the University of Pennsylvania
Attending, Pulmonary Hypertension Program, Hospital of the University of Pennsylvania
Medical Director, Mechanical Circulatory Support Program, Hospital of the University of Pennsylvania
Member, Cardiovascular Institute, University of Pennsylvania
Department: Medicine
Contact information
Penn Medicine
Heart Failure, Mechanical Assist and Cardiac Transplant Center
Hospital of the University of Pennsylvania
2 East, Perelman Center for Advanced Medicine
3400 Civic Center Boulevard
Philadelphia, PA 19104
Heart Failure, Mechanical Assist and Cardiac Transplant Center
Hospital of the University of Pennsylvania
2 East, Perelman Center for Advanced Medicine
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-615-7949
Fax: 215-349-5603
Fax: 215-349-5603
Education:Permanent link
B.S., M.S. (Molecular Biophysics and Biochemistry)
Yale College, 1990.
M.Phil (Statistics/Health Services Research)
Oxford University , 1996.
M.D. (Medicine)
Harvard Medical School , 1997.
B.S., M.S. (Molecular Biophysics and Biochemistry)
Yale College, 1990.
M.Phil (Statistics/Health Services Research)
Oxford University , 1996.
M.D. (Medicine)
Harvard Medical School , 1997.
Description of Itmat ExpertiseMetabolic Signature of Chronic Heart Failure
Cardiac Metabolism
Ventricular Assist Device Support
Right Ventricular Dysfunction in Chronic Mechanically Assisted Heart Failure
Description of Research ExpertiseMy role as an advanced heart failure clinician-scientist and director of the mechanical assist device program at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. More recently I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of "reversing" specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Tim McGraw, Dr. Richard Shannon, Dr. Ken Margulies and Dr. Tom Cappola within my own group at Penn as well as the laboratory of Dr. Christian Schulze and Professor Ira Goldberg at Columbia University.
Selected PublicationsPrashanth Vallabhajosyula, MD, MS, Matthew Kramer, BS, Sofiane Lazar, BS, Fenton McCarthy, MD,Eduardo Rame, MD, Joyce Wald, MD, Wilson Szeto, MD, Matthew Williams, MD, Pavan Atluri, MD, Nimesh Desai, MD, PhD, and Michael Acker, MD: Lower-extremity complications with femoral extracorporeal life support. The Journal of Thoracic and Cardiovascular Surgery March 2016.
Bedi KC Jr, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth AJ, Wang LL, Javaheri A, Blair IA, Margulies KB, Rame JE: Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure. Circulation 133(8): 706-16, February 2016 Notes: Epub 2016 Jan 27.
Birati EY, Mathelier H, Molina M, Hanff TC, Mazurek JA, Atluri P, Acker MA, Rame JE, Margulies KB, Goldberg LR, Jessup M: Comparison of Causes of Death After Heart Transplantation in Patients With Left Ventricular Ejection Fractions ≤35% Versus >35. The American Journal of Cardiology S0002-9149(16): 30150-3, January 2016.
Burkhoff D, Maurer MS, Joseph S, Rogers JG, Birati Eo, Rame JE, Shah SJ: Reply: Is Pump the Answer to Heart Failure With Preserved Ejection Fraction? JACC Heart Fail 4(1): 93, January 2016.
Rame JE: Metabolic Staging in Human Heart Failure: Circulating Acylcarnitines and the Failing Heart's Energetic Signature. J Am Coll cardiol 67(3): 300-2, January 2016.
Stewart GC, Kittleson MM, Cowger JA, Johnson FL, Patel CB, Mountis MM, Patel PC, Rame JE, Testani J, Guglin ME, Teuteberg JJ, Stevenson LW: Who wants a left ventricular assist device for ambulatory heart failure? Early insights from the MEDAMACS screening pilot. J Heart Lung Transplant 34(12): 1630-3, December 2015 Notes: Epub 2015 Aug 4.
McCarthy FH, Kobrin D, Rame JE, Groeneveld PW, McDermott KM, Atluri P, Acker MA, Desai ND: Increasing Frequency of Left Ventricular Assist Device Exchanges in the United States. Annals of Thoracic Surgery 100(5): 1660-4; discussion 1665, November 2015 Notes: Epub 2015 Jul 21.
Bermudez CA, Rame JE: Reversible but risky: Pulmonary hypertension in advanced heart failure is the Achilles' heel of cardiac transplantation. J Thorac Cardiovasc Surg 150(5): 1362-3, November 2015 Notes: Epub 2015 Aug 6.
Rame JE, Birati EY: HeartWare Left Ventricular Assist Device Pump Thrombosis: A Shift Away From Ramp. JACC Heart Fail 3(11): 857-9, November 2015 Notes: Epub 2015 Oct 7.
Teuteberg JJ, MD, Slaughter MS, Rogers JG, McGee EC, Pagani FD, Gordon R, Rame E, Acker M, Kormos RL, Salerno C, Schleeter TP, Goldstein DJ, Shin J, Starling RC, Wozniak T, Malik AS, Silvestry S, Ewald GA, Jorde UP, Naka Y, Birks E, Najarian KB, Hathaway DR, Aaronson KD : The HVAD Left Ventricular Assist Device: Risk Factors for Neurologic Events and Preventative Mitigation Strategies. JACC Heart Failure. (eds.). 3(10): 818-28, October 2015.
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Last updated: 08/03/2016
The Trustees of the University of Pennsylvania
Last updated: 08/03/2016
The Trustees of the University of Pennsylvania


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My colleague and Cadence Distinguished Engineer Mike Stellfox leads a group of trailblazers inside Cadence. Specifically, Mike's group is tasked with moving our most promising prototypes and methodological theories out of their incubators and into production. In this interview on the floor of DAC 2011, Mike gives a brief snapshot of the migration to the Universal Verification Methodology (UVM) by customers and EDA vendors alike, how debug is becoming much more of bottleneck than it used to be, and the momentum of System Realization with SystemC overtaking traditional, RTL-centric flows.
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Travel Blog
Posts by Hilary Sheinbaum
Sugar mogul Dylan Lauren recalls her global sweets pursuit. It was Chupa Chups that sold me. I was studying in Europe when I discovered these irresisti... Read More
It's more and more possible to bake your favorite desserts—from NYC or elsewhere—at home. Jet-setters travel worldwide for regional delicacies—Japan for ... Read More


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BROOKLYN - Lessonface.com, a Brooklyn-based online company, allows music teachers to hold group or individual music lessons to people all over the world.
Ukulele teacher Khabu Young, of Brooklyn, recently gave a music lesson from Houston, Texas, where he's on vacation.
"To be able to have this type of lesson anywhere, at any time, I think is very exciting," Young told News 12.
The site is always looking for those who have the ability to teach a musical instrument or those willing to learn.


text:
UT Press
[ Classics and Ancient World ]
Chersonesan Studies 1
The Polychrome Grave Stelai from the Early Hellenistic Necropolis
By Richard Posamentir
Joseph Coleman Carter, Series Editor
Archaeological investigations by the Institute of Classical Archaeology that examine a unique collection of Greek funerary monuments from the Black Sea.
Chersonesan Studies 1 presents the painted grave stelai of the Early Hellenistic necropolis of Chersonesos Taurike, a Greek city on the northern shore of the Black Sea. This unique collection of over one hundred objects is of major interest to students of ancient art and Greek culture. Their polychrome decoration has been extraordinarily well preserved, a rarity in the ancient world. They compose a remarkable, even unique, body of evidence of Greek funerary memorial sculpture: their shapes are gender-specific, their depicted objects are gender- and age-specific, and they can be ascribed to a handful of specific workshops. Their surprising uniformity requires an explanation, since comparable assemblages from other parts of the Greek world show substantial diversity in all these aspects.
This book provides the first complete catalog and description of the stelai, together with full-color illustrations of all the significant stelai and many details. Through his painstaking recovery and reassembling of fragments, as well as the use of advanced photographic techniques, Richard Posamentir has been able to add a whole new dimension to the study of these artifacts. The volume covers the history of the stelai, analysis of the workshops, and reconstruction of the necropolis that the stelai originally graced. A comparison chapter discusses how the stelai fit into the context of Greek funerary art and provides insights into the culture and society of a city on the Black Sea.
- Series Foreword (Joseph Coleman Carter)
- I. The Polychrome Grave Stelai from the Early Hellenistic Necropolis (Richard Posamentir)
- Acknowledgments
- 1. Introduction
- 2. Catalog of Stelai
- 3. Shape and Object Analysis
- 4. Painting
- 5. Grave Stelai Found in the Tower of Zeno
- 6. Grave Stelai found outside the Tower of Zeno
- 7. Dating of the Stelai from the Tower of Zeno
- 8. Crownings, Bases, Naiskoi, and Anthropomorphic Stones
- 9. Location and Appearance of the Necropolis in the Hellenistic Period
- 10. Comparisons with Other Funerary Stelai
- 11. Conclusion: The Necropolis, its Destruction, and the Tower of Zeno
- II. Specialist Studies
- 12. Analysis of the Inscriptions: The People of the Citadel Necropolis (Paula Perlman)
- 13. Pigment Analysis (John Twilley)
- References
- Index
Richard Posamentir is a junior professor of Classical Archaeology at the University of Tuebingen, focusing on cultural contacts in antiquity. He has participated in archaeological projects in Italy, Greece, Turkey, and the Ukraine and carried out his own survey project in Anazarbos, Cilicia/Turkey.


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The New York Times discovers IPOB
Nice, balanced treatment of the In Pursuit of Balance movement and those who think it's silly by Bruce Schoenfeld in the New York Times magazine. The very fact that this phenomenon has hit the pages of the Gray Lady is indicative of how important IPOB has become in the weltanschauung of our wine conversation.
Let me get this out of the way immediately: I've thought since IPOB's inception that they're too ideological in declaring that some wines are "balanced" and some aren't and that the dividing line is some ill-defined notion of alcoholic strength.
I don't believe I'm one of the "invective-filled…partisans" who opposes IPOB, in Schoenfeld's words; he catches the family quarrel well, but does tend to exaggerate the animosities a little bit—bringing in Robert Parker and his stinging critiques of IPOB ("jihadists," "anti-pleasure," "useless") makes things sound worse than they are. For my part, I certainly wouldn't use inflammatory language like that. But then, IPOB's supporters haven't gone after me the way they've gone after Parker. (I'm not important enough.)
If you believe IPOB you'd think that their members all make Pinot Noirs below 14%, but at the recent San Francisco tasting, there was Calera, whose wines can exceed 14.5%. For example, the 2007 Ryan I reviewed was 14.7%, and it was a very good wine I gave 93 points. But how do you explain Calera's presence in IPOB? This is not a diss of Calera, whose wines I quite like, or of Josh Jensen, whom I respect, but it is a question posed to Raj Parr and Jasmine Hirsch. Why is Calera there? Are you saying that most other Pinot Noirs of that alcohol range are "unbalanced" but by some divine intervention, Calera isn't? Enquiring minds want to know.
I give IPOB credit for sparking this conversation. Whether it's a conversation that actually leads to any responsible conclusions, however, remains to be seen. Some years ago, the conversation in California was all about "food wines"—what they are, what they aren't. Then, it was the application of oak that was at the heart of the chatter. This IPOB thing is a modern rendition of that discussion, which actually did have the positive result that it led to a renewed consideration of the proper application of oak to wine. There seems to be something self-regulating in the American wine industry—helped by social media and the chatty opinionizing that characterizes the wine industry—that perceives excesses almost as soon as they occur and tries to curtail them. This is a good thing.
But I suspect that IPOB will run its course in due time; other organizations will arise and fall, people's attention will be diverted elsewhere, California's climate will certainly play a role, and Raj, Jasmine and IPOB will go on to other, less contentious things. In the meantime, they've already succeeded in making wineries (which means winery owners) make, at the very least, contingency plans for what to do if, in fact, there is a serious consumer swing towards low-alcohol wines. I don't think there is, yet, although if you read the wine press voraciously you might be forgiven for thinking it's already happened. But this is how the media works nowadays: somebody stirs the pot, everybody starts talking about it, and the next thing you know, self-fulfilling prophecies pop up all over the place.
Have a great weekend!
Blend or single vineyard? It depends on the variety
Sauvignon Blanc is one of those grape varieties that seems to benefit from judicious blending from multiple sources in California. Cool-climate Sauvignon Blanc can be audacious and savory in gooseberries, with a touch of pyrazine that can be too green for many people. Warm-climate Sauvignon can have delicious tropical fruit flavors but be a little candied. Either, by itself, can have limitations, especially in an off-vintage; but blending them together seems to smooth out the divots. While it's true that some of my highest-scoring Sauvignon Blancs ever were Mondavi Tokalons, this is a rare exception in California; Sauvignon Blanc in our state veers towards the ordinary, and it takes some great grape sourcing and careful blending to come up with a serious wine.
Pinot Noir, on the other hand, is considerably more interesting as a single-vineyard wine. I'm not sure why, other than to trot out the usual theories of site-specificity, thinner skins and terroir transparency. Perhaps psychically we're more forgiving to a slightly flawed Pinot Noir from a vineyard. I used to wonder why a great Pinot Noir couldn't be a blend of, say, Santa Rita Hills and Anderson Valley. It can in theory, of course, but while I've experienced many, many very beautiful blended Pinot Noirs, the wine always seems more interesting and complex when the grapes are from a single vineyard.
Then there's Cabernet Sauvignon. I'm tempted to say it, too, wants to be from a single vineyard, but there are so many interesting, great Cabs that break that rule. I, personally, am a huge fan of Cardinale, which is a blend of various vineyards in Napa Valley. Yes, I work for Jackson Family Wines, but I didn't when I gave the 2006 100 points, and I've never had a Cardinale I didn't find dazzling. So I can't say that Cabernet has to be from a single vineyard to be world class.
I think Zinfandel is probably best as a vineyard-designate, although it has to be a super-great vineyard, well-tended, and, if possible, old vines. As for Chardonnay, I'm divided on that one. It's such a winemaker's wine (barrels, malo, lees) that the sourcing doesn't seem like it should matter, as long as it's from a cool climate. And yet, as I look over my Wine Enthusiast reviews, I notice that my highest Chardonnay scores were reserved for single vineyard wines: Failla 2010 estate, Williams Selyem 2010 Allen Vineyard, Rochioli 2010 South River Vineyard, Dutton-Goldfield 2010 Dutton Ranch Rued Vineyard, Ramey 2012 Ritchie Vineyard, Flowers 2011 Moon Select, Shafer 2009 Red Shoulder Ranch.
There's something intellectual about a single-vineyard wine, especially if you've been to the vineyard, walked it, had it explained to you by the winemaker or grapegrower. The Allen Vineyard, for instance, is such a distinctive place; every time I have an Allen Chardonnay or Pinot Noir, I imagine that particular place, the slight slope, the vineyard tucked up against the hills to the west, Westwide Road on the east, and the Russian River just on the other side of Rochioli. It's a "sweet spot," midway between the chill of the southern valley and the warmth of Dry Creek Valley, a lovely corner of the Russian River Valley that I hope will someday be appellated as The Middle Reach.
The market, of course, rewards single-vineyard wines. I can't prove it with data, but I bet if someone crunched the numbers, they'd find that single-vineyard wines are more expensive, on average, than blended wines. I think that a winery that produces a single-vineyard wine as a very special bottling, superior in their view to their blended wines, is in the catbird's seat, but you can't simply assume that a vineyard-designated wine has special properties. I've had plenty of sad vineyard-designated wines; some have been horrible. So you never know; you have to taste the wine. Consumers want assurances, but there are none in wine. Every rule has an exception.
Why Napa Cabernet costs so much
The most interesting quote in the Napa Valley Register's article on the 30th birthday of the Carneros Wine Alliance is from David Graves. The co-founder of Saintsbury said, "There's no 'Napa of pinot noir.' No one place dominates the market."
Isn't it interesting how the cultural evolution of the market has treated our two leading red wine types so differently? One, Cabernet Sauvignon, has become almost exclusively dominated, in the mind of the consumer, with a single appellation: Napa Valley. The other, Pinot Noir, resists being associated with a dominating region. Indeed, if you were to ask leading wine critics, What is California's top Pinot Noir appellation, they would tell you the question makes no sense.
Beyond being merely of academic interest, this is a pocketbook issue. How much a winery gets for its wine (and how much, in turn, the consumer pays for it) are intimately linked with the wine's origin. While the average statewide price for a ton of Cabernet Sauvignon grapes in 2013 was $1,339, in Napa Valley it was $5,469, a difference of 308 percent. Pragmatically, this is why the average bottle of Napa Valley Cabernet is many times higher that the average bottle of Cabernet from, say, Alexander Valley.
This is not true of Pinot Noir, whose price tends to be more consistent across all the top coastal growing areas. Here are some examples, all reflective of the price of a ton of grapes in 2013:
Sonoma: $3,078
Santa Barbara/San Luis Obispo: $2,586
Mendocino: $2,652
Statewide: $1,594
Indeed, as I have long suggested, when it comes to Pinot Noir, it is somewhat misleading to focus on individual growing regions. Instead, the way to look at things is that we have a single Pinot Noir terroir that stretches from Anderson Valley down to Santa Barbara County, extending inland perhaps 20 miles. No single A.V.A. within this vast stretch can plausibly pretend to supremacy because, in truth, all of them are roughly equal, although, of course, wine writers and critics make their livings discerning differences within the similarities.
In the case of Napa's lopsided price for Cabernet, this cannot be credited to matters of terroir. Napa Valley demonstrably is not the best, only place to grow qualitatively significant Cabernet Sauvignon in California. Alexander Valley has equal precedence. So too do the Santa Cruz Mountains, Paso Robles, the easternmost parts of Santa Barbara, Lake County and other regions of Sonoma County, including Sonoma Valley, Dry Creek Valley, Knights Valley and Chalk Hill. (I refer, in all cases, to the top wines.) I don't think any critic who's being objective would object when I say that prime Cabernet growing areas in California are at least as widespread as those for prime Pinot Noir.
Why, then, the incredible price differential on behalf of Napa Valley Cabernet Sauvignon? One reason and one reason only: perception. Napa Valley is perceived as being the best place to grow Cabernet. That perception clearly impacts the choice of consumers (and the restaurateurs and merchants who sell wine to them), but it also distorts the impressions of a surprisingly high number of critics, who do not taste blind and thus are subject to the biases within their own unconscious or subconscious minds.
Now that I've been "relieved" of the job of tasting many thousands of wines a year, I find I'm developing a refreshingly clearer sense concerning these matters of terroir. Perhaps it's a form of now being able to see the forest for the trees. If one is looking for pleasure and complexity in wine (and what else would one look for?), then it's simply astonishing how easy it is to find those qualities in California wine. This is not to suggest that quality differences do not exist, but it is my considered judgment that these differences are neither as vast as I once thought, nor as distinctive as consumers believe. This may be due, in part, to the 100-point system, which I long employed and for which I will never apologize. But I am glad that, when it came to very high scores for Cabernet, I always included Alexander Valley right up there with Napa Valley, for I was able to get past the "perception thing" and focus on the wine itself.
The history of California wine is replete with paradigm-shifting events, such as the Paris Tasting, the advent of the current era of Pinot Noir, replanting after phylloxera, and, if we go back far enough, to the use of French barriques and the creation of the Federal labeling laws. To these, I will predict a gradual shifting in the consumer's perception, a widening of appreciation that great Cabernet Sauvignon can in fact come from many more places than only Napa Valley. When this will occur is open to question, but I have no doubt that it will.
Widening the scope of what good Pinot Noir really is
It's lovely to remind people, as Randy Caparoso does in the April issue of The Tasting Panel magazine, that it's not right to evaluate wines "in terms of varietal character rather than terroir or origin."
What brought Randy to this evaluation was a tasting of Pinot Noirs. He'd encountered a 2013 Failla (Occidental Ridge Sonoma Coast) which he found to have "a dead weight on the palate." This is not a favorable description.
But the more Randy thought about it, the more he realized that the Failla was a true representative of where it came from: "a deep, foggy pocket of Sonoma" whose cool climate yields wines that are hard and tannic when young. That made him reconsider it, as well as other wines he tasted: A Merry Edwards 2012 Meredith Estate (similarly cool climate Russian River Valley), and an Adelaida 2012 from Paso Robles, from a cool, high elevation vineyard in the western part of the appellation. What Randy realized, mirabile dictu, is the importance of appreciating these wines "within their own context… [When you do], it's amazing how bright and diverse the wine world turns out to be."
Thank you, Randy. I've been making this case for many years: that you can't ask all Pinot Noirs to conform to your notion (whatever it is) of Pinot Noir perfection, because to do so is to totally trash the notion of terroir that is the basis for all Pinot Noir interpretation. Pinot likes a cool climate, but The Green Valley of the Russian River Valley is not the same as a 2,000-foot elevation Mendocino Ridge vineyard, high above the fogline, or western Paso Robles. Although all three regions are cool climate, they will yield different kinds of Pinot Noirs. It's simply wrong to denigrate one at the expense of the other—provided they're all fine examples of their terroir.
How do you know if they are or aren't "fine examples of their terroir"? Well, that's the professional task of a wine reviewer. A pro should be able to discern quality in a wine, even if it's not a wine he savors. Too often in contemporary wine reviewing, we have a situation in which a reviewer (or somm, or whoever it may be) raves about a wine that's to his liking, and disparages those that are not. In so doing, he does away with terroir's fundamental premise: that of individuality.
I love Randy's take on this delicate topic, but it does have to be said that there's a risk in tasting every wine "within its own context." And that is—you probably guessed it by now—that this is a slippery slope. Since every wine exists "within its own context," how do you ascertain that one is better than another. After all, aren't all contexts equal?
Well, no, they're not. Any wine pro knows that quality levels vary dramatically in wines. So how is the pro to distinguish between a wine that really is mediocre, versus one that (as with Randy's Failla) is "aggressive" in tannins and "plop[s] like a dead weight on the palate"?
This is an extraordinarily important question. Although Randy (by his own admission) doesn't like numerical scores, I had the feeling that, had he rated the Failla, he would have given it somewhere around 86 points and complained that it wasn't "a little finer, limber, more lifted and delineated," like a Baxter 2012 Valenti Vineyard he tasted, from Mendocino Ridge. But—and this is the whole point of his column–when he understood its origin, he was willing to give the wine a second chance.
I've long argued that blind tasting is the only way to completely eliminate bias—and Randy's palate did exhibit a certain bias towards "more lifted and delineated" Pinot Noirs, whatever that means. So how does he intellectually justify re-assessing a wine when he knows where it comes from?
This is the conundrum all reviewers face. But although it seems almost impossible to resolve it, it's actually not. Even when tasting blind, the reviewer has to ask himself, "Is this actually quite a good wine that displays the qualities of its terroir, even if they're qualities I don't like or understand? Or is it actually mediocre?" This can be a hard nut to crack, but it is crackable. One way to approach it is to ask yourself another question: "Is it ageable?" Young Pinot Noirs, especially from cooler regions, can be aggressive and hard in youth. When you're tasting such a wine, you have to imagine it six years down the road. (I use six years because in my experience that's the turning point for most Pinots that are resistant upon release. A good one will open up at six years, whereas a mediocre one will simply remain mediocre.)
Randy's column is one of the most interesting op-ed pieces I've read lately (you can find the digital edition of The Tasting Panel here, although you might have to scroll through to page 26). It raises questions of profound importance. I'm so glad that Randy has widened the scope of how we perceive Pinot Noir here in California—a scope that's been unreasonably narrowing lately due to ideological concerns among some critics.
California Pinot Noir: A followup consideration
A question arose on my blog late last week, after my March 27 post, "What about those reports that "weaker wines are better than stronger ones"?
When the comments turned to a discussion about soils, the topic of limestone arose. Now, as any historian of Burgundy (including Chablis), the Loire and Champagne is well aware, limestone (or chalk) has been considered the "bedrock" (pun intended) of those regions' terroir. Hugh Johnson, in his "World Atlas," praises the limestone of Nuits-St-Georges (to use a single instance) for causing "the inimitable sappy richness of the Pinot Noir." James E. Wilson, in his book, "Terroir," titles his chapter on Champagne "Chalk Country" and reminds us that it took centuries for "the significance of the relationship of this lifeless-looking white rock and the soils of Champagne" to be recognized.
A few California Pinot pioneers with experience in the vineyards of Burgundy recognized it. They sought chalky soil when they developed their properties. Foremost among them was perhaps Josh Jensen, at Calera, who once described to me how he had scoured the state of California, armed with geology maps and a little vial of acid, in search of limestone, which he eventually found on Mount Harlan. ("Calera" itself is the old Spanish word for "lime kiln.")
When I began visiting the Santa Rita Hills, local vintners made a big deal of pointing out the white-stone outcroppings that burst through the soil along the shoulders of Santa Rosa Road—limestone, uplifted or exposed from the now-retreated sea bed. In western Paso Robles, too, one can see these eroded white rocks, evidence not only of the California coast's birth deep below a long-gone ocean, but of the fact that there is more limestone in our state than anyone had previously thought.
The comments on my blog concerning limestone underscored its importance for Pinot Noir at such wineries as Calera and Chalone. This may well be true, although in the case of Calera the terroir is dominated by the warm summers, which in my judgment trump soil there. As for Chalone, its changes of ownership over the years have resulted in some inconsistency of the wines, which makes them difficult to appraise. If we view the broader Santa Rita Hills (and Santa Maria Valley, as well), with its fossilized seashells, it's easy to apprehend that these old chalky deposits lend a certain something to the wines (Pinot Noir and Chardonnay especially), but precisely what that "something" is, is hard to say, beyond the intriguing but amorphous word "minerality," which almost everyone in California claims to find in their wines, whether it be Zinfandels from the Sierra Foothills or Cabernets from Oakville. I will not at this time venture any further into the tall weeds of minerality.
So I see limestone, if a Pinot vineyard is lucky enough to have it, as a good thing. But so are the Gold Ridge soils of the Sonoma Coast, the barren, austere dirts of the Mayacamas stretch of Alexander Valley, the volcanic soils of the Santa Cruz Mountains, and indeed the clays and pebbles of Carneros. This is the puzzle of Pinot Noir in California: that so vast and turbulent an array of soils can consistently produce so fine a wine.
Which leaves us, then, with the only thing these regions have in common to explain wine quality: climate. (Obviously, all the different soils are well-drained, no matter their chemical composition. Well-drained soil is a necessary but not sufficient condition for the production of fine wine.) These regions all are within the Region I-Region II spectrum of the old U.C. Davis scale. I look to the warmer parts among them, such as the Middle Reach of the Russian River Valley, to give dense, textured and frankly flamboyant Pinot Noirs. The cooler areas yield silkier, more delicate and perhaps more complex Pinots, with the most complex of all coming from those places so impacted by the coast that, in a chilly year like 2011, the grapes might not get fully ripe. But in a more moderate year, like 2012, look out.
There's no point in pitting these styles one against the other. It's petulant to do so. Which is why I hold that, when it comes to Pinot Noir, California has achieved—finally—a degree of variation, based on terroir, that we long envied among the French. We need envy France no more—what we need is further exploration, fueled and paid for by consumers willing to pay the bottle price, because they know that California coastal Pinot Noir needs to offer no apologies, to anyone, for being what it is.
I do think that the lower the alcohol is on Pinot Noir, the more it will reflect its particular soil conditions; there is an inverse relationship between ripeness and the soil part of terroir. In this respect, it's important to keep in mind that the soil part of terroir is to some extent at odds with the grape itself. Which will dominate? I see this as a pitched battle between two sides. There is a school of thought that roots for terroir, another school that roots for the fruit itself. (One might almost conclude that this is the essence of the difference between "old world" and "new world" palates.) Ideally, Pinot Noir, and all wines actually, is the result of an exquisite balancing act between terroir and grape, the sort of equilibrium sometimes referred to as "tension" or "nerve,' which is more than just piquant acidity. It's rarely achieved; one hopes that any wine that gets a high score from a reputable critic comes close. This touches upon the ripeness conversation we've all been having, but does not resolve it because, in truth, there is no resolution.
In Pursuit of Balance tasting, San Francisco
A lovely tasting today at In Pursuit of Balance, really the best they've ever had. The venue was new: City View, in the Metreon Center, instead of RN74 like it was the last time I went. And what a crowd! This was clearly the buzziest place to be today if you were anywhere near San Francisco.
It's impossible to taste everything, but I did get to quite a few Pinot Noirs, mostly 2012s. In general, you can say that this is a generous vintage, yielding balanced, supple and frankly delicious wines of great structure, although in a few cases, the acids were too fierce. The best of them need age. Here are a few standouts:
Domaine de la Cote. I have not been a fan of the 2011s which were green, but 2012 was a great success. The Bloom's Field (12.5%) is sleek and streamlined, with a core of raspberries. It needs time.
Sandhi. Their '12 Sanford & Benedict (13.5%) is a real beauty, charming and supple.
Knez. This was a new winery for me, out of Anderson Valley. The '12 Demuth (13.3%) and '12 Cerise (about 13.3%) both are gorgeous, the former tight, the latter more generous. Both need time.
Hirsch. First, it was good to hear that David is back at work! The '12 East Ridge (13%) is powerful but delicate, with awesome structure. The '12 Reserve (13.1%) is a wine I'd describe as Burgundian, with mushroom and tea notes to the raspberry core. Both wines need time.
Au Bon Climat. The 2011 Knox Alexander (13.1%) is huge in flavor, explosive in raspberry essence, yet gorgeously structured and dry. It certainly needs 5-6 years in the bottle.
Wenzlau. Another new winery for me. The Estate Santa Rita Hills (13.0%) is very acidic, almost lemony, with with solid raspberry-cherry fruit. I would give it six years.
Kutch. A pair of 2013s, the Sonoma Coast (12.3%) and the Rohan Vineyard (12.3%), from the Bohan-Dillon area of Fort Ross-Seaview. Two great wines. The former is delicate, the latter more potent and dramatic. I would cellar the Rohan for six years.
Native9 2011 Rancho Ontiveros (13.4%). A great success for the vintage, pale in color, lots of acidity, plenty of finesse. Drinking beautifully now.
Here are a few pictures of some old friends.
Sashi Moorman pouring. Raj Parr in background.
Jim Clendenen, one of the immortals
Stevie Stacionis, of Bay Grape in Oakland
Carlo Mondavi. Sorry you have to crane your neck!
James Ontiveros, Native9 and Rancho Ontiveros


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Happy 21st birthday Kids' City!
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Nov 1, 2011
Microfinance Institution - Best Bank - Banco Compartamos
Few if any microlenders can boast of Banco
Compartamoss reach in Latin America after recent
expansions both in Peru and Guatemala. More are on the way as
the bank looks to grow its operations throughout the region.
After Compartamos last year transferred its Mexico listing to
its financial holding company to facilitate its first
international acquisitions, the bank proceeded to make its
first purchase abroad. This year, the bank acquired 88.7% of
Financiera Créditos Arequita (Crear), a Peruvian
microlender with a loan portfolio of $130m and market
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A tablet is a slim, light-weight computer, smaller than a laptop computer however larger than a cellular phone. The key features for a tablet are its portability, user-friendly user interface and obviously, its performance.
What can you do with a tablet?
Tablets support a big variety of running systems, from Android, iOS to the current Windows OS. You can access the app store, install games, music production suites, share images, view movies and a lot more recycle iphone.
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Please join us for Harvest Festival at St Mary Magdalene Church, Offley on Monday 3rd October at 9.30am
Offley Endowed is a small village church school serving the villages of Offley and Lilley. Our school is set in the beautiful Hertfordshire countryside just a little way from Hitchin. Our school motto is to 'Be all you can be' and as a school we believe passionately in supporting our children to develop all of their skills - not just academically, but socially and emotionally as well, within the context of an inclusive Christian community. Our ethos is based on faith in action and this means that we are committed to providing the children with a broad and balanced curriculum which provides the very highest standards of teaching and learning both inside and outside of the classroom including sports training, musical events and outdoor learning such as nature walks and tending to our school allotment.
On these web pages you will be able to get to know a little about our friendly school but the best way to get to know us is to come and see us. Visits to the school are always welcome and Mrs Smith, our office manager will be pleased to organise an appointment for you. We look forward to seeing you soon.
Anne Peck
Please join us for Harvest Festival at St Mary Magdalene Church, Offley on Monday 3rd October at 9.30am
At 2.25pm it was confirmed that the team are just coming through Wolverhampton - we are expecting them to arrive at School at 4.15pm. Please keep an eye on the website I will post a further message if things change.
Team Offley made the most their last full day at PGL, they enjoyed Kayaking in the morning and had the Party night last night. We all look forward to hearing stories of their adventures and welcoming them back to School, which has been very quiet without them!
At Offley Endowed Primary School we strive to provide a healthy, safe, caring and challenging learning environment where everyone is valued.
We aim to:
• Work in partnership with children, parents, carers and the wider community.
• Engage all children in their learning and help them to prepare for their future.
• Achieve high standards of discipline which are firm but fair.
• Promote our children's understanding of their own and other spiritual, moral and social development.
• Help them become good citizens in a multicultural society.
• Create and maintain a secure and stimulating learning environment in an atmosphere of care, trust and mutual respect.
• Deliver a curriculum that offers rich, varied and challenging opportunities encouraging an enquiring mind, creativity and academic achievement.
These aims are underpinned by our distinctive Christian character and values especially:
Honesty, Forgiveness, Responsibility, Self-worth, Respect and understanding, Care and love.
These values are explored in more detail with the children during lessons and collective worship on a programme of one per half term.
Offley School is very pleasantly located in rural North Herts. The school is organised into six classes. We are a team of friendly, hard working staff with supportive governors and parents. We are committed to Well-Being and are improving our environment and resources.
The school has established a good reputation in the community.


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Airport - less than 25km. Train Station - less than 20km. Cots on request. Private Balconies (some rooms). This modern and stylish 3 star hotel combines contemporary facilities with personal service and a feeling of privacy. It is a few minutes' w...
Knock Road, Claremorris, Co. Mayo -
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Mario Kart Wii
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" Aerial Tricks are techniques introduced in Mario Kart Wii. As the name implies, they are stunts...
Aerial Tricks
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Battle Timer


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San Pablo Doctors
Find San Pablo doctors who are part of Northern California's Sutter Health network. Sutter Health is committed to your individual needs and includes a wide range of world-class hospitals, experts and medical groups throughout the region.
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For my trapped in 90s ni**as these are cold this cw makes me think of the early 90s
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May 20, 2013 BY Aaron Hope / 7
The Nike Air 180 continues to make its presence felt in 2013 as following up on the Engineered Mesh 'Sunset' and 'Beaches of Rio' colorups, we'll get at least one more colorway to compliment the 'Terra Pack' offerings. This new Air 180 presents a wholly new look in grey with Ultramarine-ish plus soft green accents. Together with a diamond lattice upper texture and Safari on the heel atop a speckled midsole, these have quite a few attention grabbers. Let us know your thoughts after you've seen more below and stick with Sneaker News for release info.
Photos: GDB
Filed under: Nike Air Max Nike Retro Running
Tags: Nike Air 180
For my trapped in 90s ni**as these are cold this cw makes me think of the early 90s
I really hope I can get my hands on these.
Very clean, great for the summer just in time
these will sell out in seconds
U right bout that Nick... These are really nice
@NickBartzis The AM180 is my favorite shoe - and the clear underdog in a world over-run by AM90's and AM95's... (The AM93 comes a close second in my personal rankings as well).
But I wholeheartedly agree with you. This will sell out in seconds. It's pretty much, the most amazing shoe mine eyes has ever beheld... very pleasing to my optic sensors...
@KidBobot @NickBartzis Kid robot your comment was awesome lol. I am a AM90 fan myself but this colorway is really nice.
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Welcomed the second you step foot inside the door. Beautiful home, great rooms, cozy beds. Awesome breakfast. Very friendly and go out of the way to make you feel special. Love the hospitality of the South, we will be back one day.
Clean, quiet, convenient and reasonable. I'm really glad I stayed there. The neighborhood has private homes, small apartment complexes, and lots of greenery. It was unseasonably warm, so I was pleased there was a choice of central air or ceiling fans - I chose the ceiling fans. Ponce City Market is a 10 minute walk south, and Trader Joe's is 10 minutes to the north. Note: breakfast is included; there's a full kitchen and fridge if you want to prepare other meals.
David's Greenwood B&B fit our needs perfectly. It is a charming home in a nice neighborhood. We enjoyed sitting on the front porch and watching the passersby.
everything was perfect! I highly recommend this B&B. The manager was a delight and very knowledgeable about the area
Really enjoyed our stay at the Sugar Magnolia. Excellent location, beautiful house, and wonderful hosts Thank you for a wonderful vacation!
My fiance' and I went for a weekend getaway. The stay was great, food was awesome, and it felt like we were the only ones there. The only bad thing we can think of, is the home was a bit warm (74) for our liking. Other than that.... it was perfect!
A great experience! the B&B manager/chef was delightful and knowledgeable abut the are and cooked a great breakfast.
Such a beautiful Victorian in a lovely section of Atlanta! The furnishings, the delicious breakfast, and especially the delightful folks who care lovingly for this home made our visit delightful! Art and Kathy Rottenborn
The house was amazing! It was in a beautiful neighborhood and we were able to walk to restaurants and shops, perfect location! The room was cute and the little garden area off the room was perfect. The bed was comfortable and we enjoyed ourselves! We would definitely stay here again!
The feel of this B&B is like home, so cozy and comfy. I picked this B&B based on all of the glorious reviews, and I was not disappointed. My husband and I were in Atlanta to celebrate his birthday, and this location was close to everything 15 minutes either way. This would be the only place I would ever stay when in Atlanta. David the Inn keeper was joy to talk to and had wonderful spirit. He was very accommodating. When parking on the street was no existent to due a parade, he texted me to let me know that we could park in the driveway. The food was quite delicious, take it in the parlor at the front on the house and enjoy the goings on in the neighborhood. What a lovely neighborhood it is very peaceful and quiet. Love every minute of this wonderful gem in Atlanta.
My wife and I stayed here for 9 days on our honeymoon to really get a feel for the place and it was absolutely amazing. Wonderful place with a wonderful host (Kathryn) and I wouldn't have had it any other way.
We have stayed at Greenwood B and B several times in the past 2 years. We look forward to the comfort and quiet in David's lovely home. Breakfast is delicious every single time. David could not be more gracious and accommodating. We are looking forward to our next visit at Greenwood B and B!
beautiful historic area! Owner and innkeeper fabulous! We had dinner in the area and it was fantastic ( Mexican rest). The outside lanai was cozy and relaxing though too hot to sit outside. The room was spacious but could use some updating such as bedding and carpets. The bed was VERY comfortable and having a coffee room close to our bedroom was a plus :-). We will definitely visit again!
We are repeat clients of the charming Greenwood Bed and Breakfast. Staying in the Va-Hi neighborhood will totally alter your experience. So much easier to get about and you won't leave Atlanta wondering why you stayed on freeways or near malls. We love having a full kitchen/living room as we don't retire at the same hour as a couple. We also like the fact that David doesn't have clutter around. The decor is restrained and fitting for the bungalow neighborhood. We also bring back leftovers sometimes from eating out and enjoy dining in our place at Greenwood. David serves a hearty breakfast that will carry you through the day. Very hot pressed coffee, a generous egg dish and all is served on a portico overlooking the street. This is a value destination, and we can't always get in when we want to book with him. Parking on the street near the house is easy. David also allows guests to park in his drive if desired. Love the separate entrance. See you next time, David.
We had a wonderful stay at the Greenwood B & B. David, the owner is, always anxious to make your stay as comfortable as possible. The breakfasts were delicious! This place is so roomy; it truly is like being at home. I love how close it is to the Beltline and Piedmont Park. There are lots of restaurants and shopping closeby. If you stay here you won't be disappointed!!
My husband and I stayed with Ms. Eileen at Maison LaVigne. She is so kind and welcoming into her home. She is a fabulous chef (she is beyond a cook)! Our room was cleam and neat as is the entire house (that we could see). The room is comfortable.
This quick get away was fantastic! the house, room and area are spectacular, close to everything, from historical to fine dinning. The breakfast was delicious and the people were amazing hostess. We are so glad we stayed in this beautiful gem in ATL. Highly recommended!
Great service, terrific breakfast, ideal location, and very comfortable accommodations. We had an awesome stay and can't wait to return.
We recently spent the weekend at 12 Oaks. So often when you see something on the Internet when you get there it is a disappointment. 12 Oaks was everything it presented itself to be. Our room was beautiful, the breakfast was exceptional. The location was perfect just a walk to a charming town. We would definitely recommend it and intend to go back.
Sugar Magnolia is beautiful, comfy, and cozy. The rooms are fabulously decorated, and Kathryn was incredibly sweet and helpful.
Nice b&b with excellent food...
Eileen was a great host, prepared a wonderful breakfast that included fresh fruit that she had picked that morning. Ideal location if your flying out of Atlanta. About two miles from the international terminal.
A friend and I spent one night at this bed and breakfast recently and we had an exceptional experience. The room was clean and interestingly furnished and decorated. The bed was very comfortable. We met some wonderful guests that spent time with and had a great time! The owner of the B&B was delightful. She was full of interesting stories and charm, and she is a phenomenal cook. She also was very amenable to working around our schedule and requests. I would absolutely visit this B&B again if my travels bring me back to the area. If you are considering staying here, please book through their website directly so that the owner doesn't lose out because of fees charged by secondary sites like hotels.com. HIGHLY RECOMMENDED!!!!!
I can not say enough nor put into words, what an amazing getaway this was for me and for my dad! Everything from the location, room, grounds of the property, breakfast and Eileen's hospitality and kindness towards me and my father are enough reasons for me to want to book with her again! By far one of the best Bed and Breakfasts that I have stayed in. Thank you for making this Fathers Day a special one for my dad!
Inman Park rocks
Exceeded expectations, bed so comfortable, food delious and unique.
I think what impressed me most about Greenwood B&B, was the quiet; the sound of the birds was all I heard in the neighbourhood, and the quiet elegance of the furnishings and the entire space of the accommodations. The coffee was excellent, the bed was perfect, as was the shower, and everything I needed was right where it should have been. It was wonderful, and I'd return in a flash...as clearly everyone who signed the guest book, felt as well.
My husband and I stayed three nights in January as I had medical appointments. Beautiful historic inn is located in lovely Inman Park. Spacious, peaceful and relaxing rooms with extremely comfortable beds. Kathryn, our hostess made our stay so memorable! She is an extremely shilled cook and was able to make perfect Dutch Babies the following morning after we mentioned them! I had no idea, nor did I expect her to do that, but they were very much appreciated and absolutely delicious! She is a priceless asset to this inn and went on and beyond my wildest expectations of a hostess! Kathryn you are a Jewell! Thank you for making our time there a truly amazing experience!
We have stayed at the Greenwood Bed and Breakfast several times. Clean, quiet, comfortable, roomy apartment and David makes delicious breakfast. David takes great care in accommodating our schedules and comfort. We look forward to our next visit!
We enjoyed our stay at the Sugar Magnolia. It's a very well kept place with friendly service, and the breakfast was delicious! Would definitely stay again.


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This review is from: Cuisinart CPT-320 2-Slice Compact Stainless Toaster
Pros: My great grand parents needed a toaster manuel but why do you think I am stuiped and charge me for a printed manuel on how to use a toaster in the year 2014. You and every other Mfg. of toaster. Must be me, but I don't need to pay you to tell me how to use a toaster. My Tech Knowledge is High enough to know how to use a toaster.
Cons: When you purchase a toaster, why do they give you a printed manuel( in twelve different languages, in 37 different dialects)
. "Adjust Light/Dark knob. Put bread into slots push handle down. Wait." Now who doesn't know how to use a toaster? Did anyone ever read the manual that came with your toaster? Our Greatgradparents knew how to use a toaster.Our Grandparents kenw how to use a toaster. Our parents knew how to use a toaster. We know how to use a toaster. Our kids know how to use a toaster. Our Grandkids know how to use a toaster. OurGreat grandkids know how to use a toaster. Hells Bells! The Bum on the Street knows how to use a toaster when he had one!
So why do they give us a printed manual in 2014?
Other Thoughts: no other thoughts. I am completely dumbfounded. MUST BE ME!READ FULL REVIEW
This review is from: LG Black 16X BD-R 2X BD-RE 16X DVD+R 5X DVD-RAM 12X BD-ROM 4MB Cache SATA Blu-ray Burner WH16NS40
Pros: good price
Cons: Blu-Ray display is grainy with LG firmware installed.READ FULL REVIEW
This review is from: MSI Z87-GD65 Gaming LGA 1150 Intel Z87 HDMI SATA 6Gb/s USB 3.0 ATX Extreme OC High Performance Triple CFX/ SLI Intel Motherboard
Pros: I like the board overall. I got 1 in Feb. and 1 May 20.
Cons: No Beep. Neither of the machines beep when they start. The speakers are conneted to JFP2 with the supplied Blocks and without them. I turned them upside down when using without the Blocks. But they just don't Beep. I thought it odd the first one did't Beep, but now the second board won't Beep either, leads me to believe this is like the GM ignition coverup. MSI HAS to know this problem exists with this board. I am using the supplied speakers that came stock with both boards.
Other Thoughts: No BeepsREAD FULL REVIEW


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This prefetching is performed in the background, so that the DNS is likely to have been resolved by the time the referenced items are needed. This reduces latency when the user clicks a link.
DNS requests are very small in terms of bandwidth, but latency can be quite high, especially on mobile networks. By speculatively prefetching DNS results, latency can be reduced significantly at certain times, such as when the user clicks the link. In some cases, latency can be reduced by a second.
The implementation of this prefetching in Firefox allows domain name resolution to occur in parallel with (instead of in serial with) the fetching of actual page content. By doing this, the high-latency domain name resolution process doesn't cause any delay while fetching content.
Page load times -- especially on mobile networks -- can be measurably improved in this way. If the domain names for images can be resolved in advance of the images being requested, pages that load many images can see an improvement of 5% or more in the time of loading images.
Configuring prefetching in the browser
In general, you don't need to do anything to manage prefetching. However, the user may wish to disable prefetching. On Firefox, this can be done by setting the
network.dns.disablePrefetch preference to
Also, by default, prefetching of embedded link hostnames is not performed on documents loaded over HTTPS. On Firefox, this can be changed by setting the
network.dns.disablePrefetchFromHTTPS preference to
Controlling prefetching from content
Content providers have some control over the prefetching process as well.
Turning on and off prefetching
First of all, a server can opt out of DNS prefetching by serving content with the
This can also be done from individual documents, using the
http-equiv attribute on the
<meta> element, like this:
<meta http-equiv="x-dns-prefetch-control" content="off">
You can reverse this setting by setting
content to "
Forcing lookup of specific hostnames
The content provider can force the lookup of specific hostnames without providing specific anchors using that hostname by using the
rel attribute on the
<link> element with a link type of
<link rel="dns-prefetch" href="http://www.spreadfirefox.com/">
In this example, Firefox will pre-resolve the domain name "www.spreadfirefox.com".
Similarly, the link element can be used to resolve hostnames without providing a complete URL, but only, by preceding the hostname with two slashes:
<link rel="dns-prefetch" href="//www.spreadfirefox.com">
Forced prefetching of hostnames might be useful, for example, on the homepage of a site to force pre-resolution of domain names that are referenced frequently throughout the site even though they are not used on the home page itself. This will improve the overall performance of site even though the performance of the home page may not be affected.


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Ramen, sushi at new Osaka Little Japan on Farwell
Osaka Little Japan, a restaurant serving sushi and ramen, has opened at 2336 N. Farwell Ave., formerly the site of Ichiban.
While some restaurants in Milwaukee offer ramen as specials, Osaka appears to be the city's first to offer ramen full time. The Japanese noodle dish served in broth with assorted additions has gained in popularity across the U.S. »Read Full Blog Post
Free beer, bands attract crowd to local label's SXSW showcase
When it comes to pulling off a successful showcase during the South by Southwest Music and Media Conference, a prime location in downtown Austin, Texas, is a key factor.
Except when it isn't. »Read Full Article(1)
Skylight Music Theatre finds power in 'Hydrogen Jukebox'
Just before intermission at Friday's opening performance of "Hydrogen Jukebox" — Skylight Music Theatre's production of a song cycle featuring Philip Glass' music and Allen Ginsberg's poetry — the ornate Cabot Theatre hosted a backroom poetry reading.
Clutching a poem and speaking into an old-fashioned microphone, baritone Dan Kempson channeled Ginsberg reading from "Wichita Vortex Sutra," written as Ginsberg traveled through Kansas during the height of the Vietnam War. »Read Full Article
MSO Pops, Cherish the Ladies show St. Patrick's Day spirit
Nothing says "Happy St. Patrick's Day" quite like an evening of Irish music and dance, particularly when the group performing is Cherish the Ladies and singer Cathie Ryan.
The Milwaukee Symphony Orchestra Pops, led by guest conductor Michael Krajewski, joined forces Friday with the internationally acclaimed, all-female group for a high-energy evening of Irish music — both traditional and recently written — and dance. »Read Full Article
Jennifer Nettles right at home in solo show at Riverside Theater
What path would Jennifer Nettles, the big-voiced half of the country-pop super duo Sugarland, take with her first steps toward solo stardom?
The first answer to that question came in January with the release of her debut album, "That Girl." The Rick Rubin-produced disc both employed and harnessed the potency and emotional depth of Nettles' voice and four years of songwriting reflection. »Read Full Article
Hank the dog connects with Brewers owner, others
Milwaukee Brewers owner Mark Attanasio calls Hank the Brewers dog his favorite new mascot.
"This is the start of my 10th season, and the first time People magazine ever wanted to interview me was about Hank," Attanasio said. »Read Full Article(18)
SXSW 2014 Reviews: Mary Lambert, Aloe Blacc, A Great Big World, Phantogram, Typhoon
From a kid-approved Phantogram set to an Aloe Blacc dance party in a parking lot to a moving Typhoon performance set in a church, here's some of what I caught at the South by Southwest Music and Media Conference Thursday.
PHANTOGRAM »Read Full Article


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Variety Insight premium subscribers can access phone, email and more.
Will Slocombe
Senior Event Producer
: Film Independent
Access the industry's most accurate development and production listings,credits,contact info, org charts, box office, TV ratings and more.
|Film Title
|Job Title
|Release Date
Gunpowder & Sky Distribution
|Director, Credited Writer
Midway Films (DEFUNCT)
Burn Later Productions
|November 12, 2013
Want to see projects Will Slocombe is developing? Visit Variety Insight .
Latest Headlines: Will Slocombe
There are many ways to be a winner at this year's Los Angeles Film Festival. In addition to the standard fiction and documentary sections, the 21st edition includes three other competitive…
Peter Bogdanovich and Mira Nair have been tapped to receive awards at this year's Woodstock Film Festival, with the 14th annual fest in upstate New York announcing its complete 2013 slate and adding…
A fine performance by Peter Bogdanovich lends some — but not nearly enough — vitality to this middling dysfunctional-family dramedy.
Peter Bogdanovich, Cheryl Hines, Alicia Witt and Ashton Holmes are headed to "Pasadena," toplining the indie comedy-drama.
One of the most eagerly and long-awaited series follow-ups in screen history delivers the goods.
The popular Premieres section of the 2008 Sundance Film Festival is filled with the customary selection of movies featuring stars venturing outside the mainstream to do something presumably more…
To say that Paramount's "Indiana Jones and the Last Crusade" may be the best film ever made for 12-year-olds is not a backhanded compliment. What was conceived as a child's dream of a Saturday…
Just as "Return of the Jedi" seemed disappointing after the first two "Star Wars" entries, so does "Indiana Jones and the Temple of Doom" come as a letdown after "Raiders of the Lost Ark." This is…
"Raiders of the Lost Ark" is the stuff that raucous Saturday matinees at the local Bijou once were made of, a crackerjack fantasy-adventure that shapes its pulp sensibilities and cliff-hanging serial…
"Close Encounters of the Third Kind" is a daring film concept which in its special and technical effects has been superbly realized. Steven Spielberg's film climaxes in final 35 minutes with an…
Paramount's third pass at The Great Gatsby is by far the most concerted attempt to probe the peculiar ethos of the Beautiful People of the 1920s. The fascinating physical beauty of the $6…


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Missed the live Ask the Expert event?
Not to worry. Check out the archived thread of the Q&A with Ken Hutcheson, President of U.S. Lawns, and the LawnSite community in the Franchising forum .
A couple of questions
Discussion in 'Digital Marketing' started by LawnsharkMB, Dec 15, 2013.
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Page 1 of 2


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Stephen Kiernan's debut novel satisfies thrilling 'Curiosity'
Published in 1818, Mary Shelley's "Frankenstein" imagined the possibility of science re-animating dead matter, and the themes in her masterpiece have been as enduring as the Hollywood images of a block-headed, neck-bolted monster. What are the moral responsibilities of our scientific capabilities? Just because we can, should we?
Like Shelley's novel, Stephen P. Kiernan's intriguing debut, "The Curiosity," begins in the Arctic, where scientist Kate Philo leads an expedition to find the perfect "hard-ice" from which to re-animate single-cell life forms. The funding for the expedition comes from Erastus Carthage, a monomaniacal media-savvy genius who appoints Daniel Dixon, a lecherous mediocre journalist, to document the project. »Read Full Article
Hank the dog part of Brewers' home rotation
The Brewers' newest recruit, Hank, is already a fan favorite. He has more than 1,000 Twitter followers at @BrewersHank. Hank has a team shirt and a team leash.
And he has a routine he follows, just like everyone else on the ballclub. »Read Full Article(36)
26 ways to raise a reader
Whether they are toddlers or teens, reading with your children will enhance their education while strengthening your connections as a family. Short on ideas for motivating your kids to pick up a book? Never fear, with the following ideas, nurturing your children's journey into a world of wonder, exploration and information is as easy as ABC. »Read Full Article
Chef Andrew Miller leaves Hom for the new Zarletti restaurant in Mequon
Andrew Miller has left Hom Wood-Fired Grill in Brookfield to become the executive chef of Salotto Zarletti in Mequon, the new Brian Zarletti restaurant that's expected to open in early spring.
"The menu will feature modern riffs on southern and central regional Italian cuisine," Miller said via email. His last day at Hom was Saturday. »Read Full Blog Post
Time Warner adds 'broadcast TV fee,' blames retransmission fees
Time Warner Cable has announced that a 40% increase in retransmission consent fees is forcing the company to add "a new line item called the Broadcast TV fee" onto customer bills to "make customers more aware of these rising costs."
The broadcast TV fee for new or non-promotional video customers is $2.25, and represents a 6% increase. However, according to Time Warner, 70% of its customers won't see any immediate boost because they are in a promotional package. »Read Full Blog Post(31)
Eastside Music Tour to kick off festival season early
Who said you have to wait until summer for a music festival?
Milwaukee's favorite warm-weather pastime gets an early start Saturday for the second annual Eastside Music Tour, with 86 acts occupying 32 businesses on and around E. Brady St. »Read Full Article
10 must-see acts at the Eastside Music Tour
Earlier this month, the Milwaukee Journal Sentinel ran a feature on 10 Wisconsin bands to watch, profiling some of the most talented emerging artists in the state.
Eastside Music Tour-goers can watch six of those acts Saturday. Four of them will appear at a Wisconsin Bands to Watch showcase at the Tap Milwaukee Stage at Club Brady, 1339 E. Brady St. »Read Full Article
DeVita brings war to the home front in 'An Iliad'
American Players Theatre standout Jim DeVita, now 53, freely admits that actors, like the rest of us, have stretches during which they wonder why they bother — and whether anyone out there is listening or cares.
But imagine being dogged by this sense of futility for 3,000 years. That's the situation confronting the bone-weary Poet in "An Iliad," a powerful, one-actor adaptation of Homer's poem by director Lisa Peterson and actor Denis O'Hare. »Read Full Article
Reading the John Updike stories: 'Dear Alexandros'
I'm reading and commenting on a story from The Library of America's recently published 'John Updike: The Collected Stories' each Wednesday until I finish the collection or give up.
Reading John Updike's early stories -- today's story is the 24th in the first volume of the LOA's collection -- has made me marvel at how well Updike wrote in his 20s. But this project has also made me wonder about the standards for publishing fiction at The New Yorker in 1950s. "Dear Alexandros," published Oct. 31, 1959 in The New Yorker is so slight I wonder why the magazine published it. Did it need a short short story to fill a hole? Was the competition weak? »Read Full Blog Post
Coundown to Spring: 23 Days
Yep, it's still February. But we can almost touch March now. It's right there.
Hey ya! Outkast to headline Summerfest June 29
Get ready to shake it like a Polaroid picture at Summerfest. Outkast, the recently reunited hip-hop duo of "Andre 3000" Benjamin and Antwan "Big Boi" Patton, is headlining the Big Gig on June 29, with genre-jumping guitar master Gary Clark Jr. opening.
The first hip-hop act to win the Grammy for album of the year — for 2003's seminal smash "Speakerboxxx/The Love Below" — Outkast announced in January that it would get back together after a seven-year hiatus to headline 40 festivals in honor of its 20th anniversary, although Big Boi recently revealed that a new album is not in the works. »Read Full Article(10)


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Made this for one of the ladies that looks after my kids at daycare that is having her first baby. The dog looks black and white but it was actually chocolate fondant so was brown over chocolate mud cake.
CakeCentral.com is the world's largest cake community for cake decorating professionals and enthusiasts.
(if this is a private computer)
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Physicians joke that "Viagra" has something common with a baseball bat: a shock remedy, simple and effective! Here, at the pages of our site, we will see whether, its true or not and get to know where to buy cheap Viagra without prescription.
The body of every man produces a special enzyme, which, if necessary block the blood flow to the penis. But sometimes the enzyme in the body begins to act, not when needed. In such cases can help Viagra. When a man takes the drug, the inner cells of the penis produce a specific vast "malicious" enzyme. The muscles of cavernous bodies are relaxed and the blood easily enters the penis. The men should remember, that they can buy Viagra online, but if they want to achieve great results they have also provide sexual stimulation by themselves, or with the help of their partners. Even if you eat a whole box of tablets, but before your eyes there is no a suitable facility, the erection will not occur. The brain has to get the corresponding momentum. And this is not the problem, as typically these messages male brain receives during the whole day.
Today an uncountable number of men around the world say many thanks to Viagra manufactures, for giving them amazing chance to feel sexual power again.
Many of us, when order Viagra online, don't know about its history. Twenty years ago, Pfizer was developing a medicine for chest pain from angina. The group taking the drug test, which was to increase blood flow to the heart muscle. Much-anticipated effect has not been received, but the male half of the treatment was delighted and expressed desire to continue therapy. It turned out, this new cardiology drug dilates the blood vessels of the penis. Interestingly, earlier, many doctors for years have been trying to achieve this effect.
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All Product Details
The Mote In God's Eye is their acknowledged masterpiece, an epic novel of mankind's first encounter with alien life that transcends the genre.
Jerry Pournelle, a past winner of the John W. Campbell Award, has collaborated with Niven on numerous bestsellers. He has also written such successful solo novels as Janissaries and Starswarm. He lives in Studio City, California.
Larry Niven and Jerry Pournelle were the joint winners of the 2005 Robert A. Heinlein Award.
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