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You'll recognize Rachmaninoff's concerto from its use in iconic films including The Seven Year Itch and Clint Eastwood's Hereafter. Now explore the depths of the piece as you only can when it's experienced live.
Note: It is with great regret that pianist Kirill Gerstein must cancel his appearance with the Utah Symphony on March 25 and 26. He and his wife are expecting their second child anytime between the middle and the end of March and he understandably wants to be home in Berlin for the birth. George Li, silver medalist in the 2015 International Tchaikovsky Competition, will perform Rachmaninoff's Piano Concerto No. 2 in his place.

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It was Halloween @WIHS tonight. @LauraKraut became Little Red Riding Hood to win the $35,000 Costume class with And…
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Congrats to this speedy pair in the #WIHS Shetland Pony Race! #barnnight2016 #horsesinthecity
Retweeted by USEFNetwork 10/27/2016 9:11:11 PM
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.@houghjumps and Ohlala take the $35,000 Welcome Stake @WIHS. 🇺🇸 👏
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The $35,000 Welcome Stake jump off @WIHS. Will it be D. Will, A. Robitaille, S. Sweetnam, A. Derbyshire, L. Kraut, or L. Hough? 🤔🇩🇪🇺🇸🇮 10/27/2016 4:06:09 PM
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Live Now! The $35,000 Welcome Stake @WIHS. Watch:
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More fun @WIHS: Shetland Pony Racing & the $35,000 Int. Jumper Costume Class take place tonight! #ponypower Watch:…
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It was a close one at tonight's @WIHS $10,000 International Jumper Time First Round but Andrew Kocher and Uppie de…
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Dean Dignelli and Redefin come home with the $10,000 @WIHS Adult Jumper Championship tonight! #wihs2016…
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Live Now! The $10,000 @WIHS Adult Jumper Championship followed by the $10,000 International Jumper (Timed First Ro…
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Congratulations to Scott Stewart on his 9th Leading Hunter Rider title at @WIHS
Retweeted by USEFNetwork 10/26/2016 4:44:53 PM
Summer in the Rockies Begins Week Two with Wins by Janine Weatherby in the 1.40m and Kristen VanderVeen in the 1.30m
RELEASE: June 13, 2013
AUTHOR/ADMINISTRATOR: Carrie Wirth for Phelps Media Group, Inc. International
Kristen VanderVeen and Bull Run's Le Conte siezed the 1.30m Open Jumpers
Parker, CO
- On the first day of week two of Summer in the Rockies at the Colorado Horse Park, staff, show management and competitors got serious about helping nearby communities ravaged by wildfires. The wildfires span 8,000 acres. A major fire is concentrated in the heavily wooded Black Forest area, northeast of Colorado Springs. Thousands have been evacuated and 80 to 100 homes have been destroyed in the blaze.
"Right now we have a few people headed into Black Forest to bring 50 horses to the property and we're also building some steel pens on our western arena to have some extra space for horses," said Brian Curry, Vice President of Colorado Horse Park. "We also have some cows and farm animals coming. We're going to do as much as we can to help out in this situation. We're pretty full as it is. We're going to create some extra space to utilize the upper paddock area. The horses that live here will stay inside so we have some extra paddock areas to use."
Brian confers on a regular basis with his brother-in-law, a Fire Chief for San Jose, CA. The Horse Park, equipped with many water trucks, a dedicated staff and a mission to contribute to the community, is a safe zone in an area that has witnessed wildfires throughout the years.
"This is our second-go-round at a pretty major catastrophe here in Colorado," Curry continued. "Two years ago we had burning tree fires. We had trailers lined up from around the main entrance in and around the barns. We had more trailers than horses. It was kind of neat to see that many people come together to help. We were able to extract 100 plus horses to this facility in 45 minutes."
"We have had people asking all day how they can help," said Marion Maybank, who works with Showplace Productions, the show management company for Summer in the Rockies. "They'd say, 'If you have a truck and trailer, I can go get some horses.' Joel Rifkin called earlier and said, 'I have trucks and trailers but I don't have drivers.' We had some volunteers and sent them over."
With no real fire risk to the Colorado Horse Park, competition went on as planned, and the Open Jumpers warmed up on the first day of week two with Danny Foster's courses.
"I always make the jumping on Wednesday and Thursday very friendly and very inviting," Foster said. "It's a good day for horses to move up a division and try something new. The older proven horses, particularly the grand prix horses, usually don't show on Wednesday. And it gives me a chance to see what I've got here, which riders are here and the caliber of their horses. I am sensitive to the idea that the horses have a long way to go on this tour and I'm trying to not use them up too hard in the process."
Kristen VanderVeen, a well-known face at the Colorado Horse Park, went 17th in a field of 19 in the 1.30m Open Jumpers and pulled off the win aboard Bull Run's LeConte, owned by Empire State Equine Sales LLC. VanderVeen also won the 7/8-Year-Olds with Bull Run's Revive.
"Bull Run's Le Conte is a 12-year-old horse that I have been doing in the grand prixes," VanderVeen said. "This is his warm-up. That actually gives me a lot of confidence. I wanted to take it a little slower with and give him an easier class since they changed the footing here. It has turned out quite nicely. The horses seem to be jumping off of it really well and he seems really comfortable. I'm really excited to see how we'll be in the Welcome and the Grand Prix."
Like all the competitors, VanderVeen has been kept abreast of the situation with the wildfires.
"I had heard that they were bringing horses from the surrounding areas into the Park," she said. "I think that is great. The organization seems really great. They are really on top of it, communicating and keeping everyone calm and aware of the situation."
The winners of the 1.40m Open Jumpers, Janine Weatherby and Chris Falewitch's 16-year-old Panache, have had a long relationship.
"I got him as a 3-year-old," Weatherby said. "Andy Barone hacked him once for me and said, 'That's never going to happen. No one is ever going to be able to ride him except you.' He has a little hesitation in front of the jump and he's getting so he doesn't even do that anymore. The older he gets the higher he jumps and the better he is."
Panache is a Thoroughbred and Weatherby did the 1m Thoroughbred Jumpers when she was in Scottsdale to support the Thoroughbred division. In addition to Panache, she brought some youngsters to the Colorado Horse Park to show during Summer in the Rockies.
"I've got all babies," Weatherby shared. "All three I've raised by my other Grand Prix stallion who's now retired. I have my 5-year-old stallion who beat the 6-year-olds last week- so we were very happy. He'll hopefully do that again tomorrow. I hope to go to Kentucky and do the 5-year-olds there. He also did the hunters with Kim Barone and she loved him. It was really easy for him. The other two are a Baby Green and a Pre Green horse."
"I haven't been here in ten or twelve years but I love this footing," Weatherby continued. "Panache is peculiar about his footing. He doesn't leave the ground very well if he doesn't like it and he actually loves the footing here. I love Danny Foster's courses. He makes them difficult enough without killing anybody. "
Everyone seems to agree on the new footing at Colorado Horse Park.
"I think they did a great job with the footing," VanderVeen said. "They really listened to the exhibitors and they responded really well to that. The ground could get really hard out here before with the sand. To me, this is great. I came this year the whole time because you can jump them now the whole six-week series because of the footing. It is a great change."
"Rudy Leone did the new footing," Foster said. "He did a good job. I had suggested that they consider him, seeing his work in Woodside, CA. He's very good at it. The horses are jumping great."
Exciting jumper action continues on Thursday of week two of Summer in the Rockies with the $15,000 Welcome Stake in the Kathy and Brad Coors Grand Prix Arena at the Colorado Horse Park.. And with a little luck, the winds will subside to allow firefighters to contain the wildfires to the south of the Horse Park.
942. $300 1.20 M Jumper
1 340 Cannon Carli Kirsch Carli Kirsch
2 288 Bonaire Serenity Farm Kelli Clevenger
3 385 Gama Righter Z Ceinwen Muma Ceinwen Muma
4 753 Felix Harriet Bunker Harriet Bunker
5 342 Little Miss Sunshine Allison Kroff Allison Kroff
6 391 Chantico Forest View Farm & Karen Ball John Pearce
7 845 Blue North Caitlin Burns Caitlin Burns
8 754 Can Do Toby Cromwell Harriet Bunker
947. $500 1.25 M Jumper
1 380 Mont Blanc Ceinwen Muma Bjorn Ikast
2 271 Jetsetter 3E Cora Leeuwenburg Armando Hassey
3 221 Emilio Tony Font Tony Font
4 351 Lightning Shale Harper Shale Harper
5 853 MTM Balvino Brandon Howard Brandon Howard
6 243 Quickie Natascha Gates Natascha Gates
7 322 Nele Bjorn Ikast Bjorn Ikast
8 182 Sir Sean Jordan Dean Matt Cyphert
585. Open Jumper 1.3M
1 485 Bull Run's Le Conte Empire State Equine Sales, LLC Kristen Vanderveen
2 234 Sheishof's Gloria Ashton Galo Paley Ashton Galo Paley
3 339 Frog Carli Kirsch Carli Kirsch
4 854 Vernon G Kelsey Van Ackeren Kelsey Van Ackeren
5 169 S & L Zeppelin Caroline Beecherl Caroline Beecherl
6 461 Zenith Dance Page Tredennick Sarah Tredennick
7 227 Kissimmee Deana Blackburn Tony Font
8 355 Clarissa Laura Love Laura Love
587. Open Jumper 1.4M
1 470 Panache Chris Falewitch Janine Weatherby
2 338 Casco Carli Kirsch Carli Kirsch
3 237 Soulshine Equestrian Investments, L.L.C. Courtney Frederick
4 279 Eminem Taggert Enterprises LLC Armando Hassey
5 233 Calotta Ashton Galo Paley Ashton Galo Paley
560. $500 Low Jr/A/O Jumper
1 341 Quite Quick Jennifer Flynn Delaney Flynn
2 174 Quinta Jacqueline Ward Jacqueline Ward
3 175 Nala Jacqueline Ward Jacqueline Ward
4 181 Ralmea Z Blair Julia Wright Blair Julia Wright
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Dressage and Para-Dressage FEI Updates for 2017
The following updates to the disciplines of dressage and para-dressage will take effect January 1, 2017. Dressage The FEI Dressage Tests for Seniors, Young Riders, and Juniors have received minor updates and have been published on Inside.FEI.org ....
Wilson Scores Back-to-Back USEF Pair Horse Driving National Championship Titles at Hermitage Classic CDE
Goshen, Ky. – The Hermitage Classic CDE played host to the 2016 USEF Pair Horse Driving National Championship on October 21-23. The picturesque Hermitage Farm provided the backdrop for Steve Wilson to claim his second consecutive championship ...
O'Donoghue and Lowe Earn USEF One-Star Eventing National Championship Titles
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USEF Announces 2017 U.S. Saddle Seat Young Riders Teams Coaches
Lexington, Ky. - The United States Equestrian Federation (USEF) is pleased announce the selection of the coaches for both of the 2017 U.S. Saddle Seat Young Riders Teams. The coaching team of Avery Bul, Scott Matton, and Michelle McVey Haisch will ...
TJ O'Mara Wins Pessoa/US Hunter Seat Medal Final presented by Randolph College at the Pennsylvania National Horse Show
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Most Cited Frontiers in Neuroendocrinology Articles
The most cited articles published since 2011, extracted from Scopus.
Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: A review of single administration studiesPeter A. Bos | Jaak Panksepp | Rose Marie Bluthé | Jack van Honk
Volume 33, Issue 1, January 2012, Pages 17-35
Steroids and peptides mediate a diverse array of animal social behaviors. Human research is restricted by technical-ethical limitations, and models of the neuroendocrine regulation of social-emotional behavior are therefore mainly limited to non-human species, often under the assumption that human social-emotional behavior is emancipated from hormonal control. Development of acute hormone administration procedures in human research, together with the advent of novel non-invasive neuroimaging techniques, have opened up opportunities to systematically study the neuroendocrinology of human social-emotional behavior. Here, we review all placebo-controlled single hormone administration studies addressing human social-emotional behavior, involving the steroids testosterone and estradiol, and the peptides oxytocin and vasopressin. These studies demonstrate substantial hormonal control over human social-emotional behavior and give insights into the underlying neural mechanisms. Finally, we propose a theoretical model that synthesizes detailed knowledge of the neuroendocrinology of social-emotional behavior in animals with the recently gained data from humans described in our review. © 2011 Elsevier Inc.
Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric diseaseDarryl W. Eyles | Thomas H J Burne | John J. McGrath
Volume 34, Issue 1, January 2013, Pages 47-64
Increasingly vitamin D deficiency is being associated with a number of psychiatric conditions. In particular for disorders with a developmental basis, such as autistic spectrum disorder and schizophrenia the neurobiological plausibility of this association is strengthened by the preclinical data indicating vitamin D deficiency in early life affects neuronal differentiation, axonal connectivity, dopamine ontogeny and brain structure and function. More recently epidemiological associations have been made between low vitamin D and psychiatric disorders not typically associated with abnormalities in brain development such as depression and Alzheimer's disease. Once again the preclinical findings revealing that vitamin D can regulate catecholamine levels and protect against specific Alzheimer-like pathology increase the plausibility of this link. In this review we have attempted to integrate this clinical epidemiology with potential vitamin D-mediated basic mechanisms. Throughout the review we have highlighted areas where we think future research should focus. © 2012.
The neurobiology of pair bonding: Insights from a socially monogamous rodentKimberly A. Young | Kyle L. Gobrogge | Yan Liu | Zuoxin Wang
Volume 32, Issue 1, January 2011, Pages 53-69
The formation of enduring relationships between adult mates (i.e., pair bonds) is an integral aspect of human social behavior and has been implicated in both physical and psychological health. However, due to the inherent complexity of these bonds and the relative rarity with which they are formed in other mammalian species, we know surprisingly little about their underlying neurobiology. Over the past few decades, the prairie vole (Microtus ochrogaster) has emerged as an animal model of pair bonding. Research in this socially monogamous rodent has provided valuable insight into the neurobiological mechanisms that regulate pair bonding behaviors. Here, we review these studies and discuss the neural regulation of three behaviors inherent to pair bonding: the formation of partner preferences, the subsequent development of selective aggression toward unfamiliar conspecifics, and the bi-parental care of young. We focus on the role of vasopressin, oxytocin, and dopamine in the regulation of these behaviors, but also discuss the involvement of other neuropeptides, neurotransmitters, and hormones. These studies may not only contribute to the understanding of pair bonding in our own species, but may also offer insight into the underlying causes of social deficits noted in several mental health disorders. © 2010 Elsevier Inc.
Prosocial effects of oxytocin and clinical evidence for its therapeutic potentialNadine Striepens | Keith M. Kendrick | Wolfgang Maier | René Hurlemann
Volume 32, Issue 4, October 2011, Pages 426-450
There has been unprecedented interest in the prosocial effects of the neuropeptide oxytocin in humans over the last decade. A range of studies has demonstrated correlations between basal oxytocin levels and the strength of social and bonding behaviors both in healthy individuals and in those suffering from psychiatric disorders. Mounting evidence suggests associations between polymorphisms in the oxytocin receptor gene and prosocial behaviors and there may also be important epigenetic effects. Many studies have now reported a plethora of prosocial effects of intranasal application of oxytocin, including the domains of trust, generosity, socially reinforced learning, and emotional empathy. The main focus of this review will be to summarize human preclinical work and particularly the rapidly growing number of clinical studies which have identified important links between oxytocin and a wide range of psychiatric disorders, and have now started to directly assess its therapeutic potential. © 2011 Elsevier Inc.
Sexual differentiation of human behavior: Effects of prenatal and pubertal organizational hormonesSheri A. Berenbaum | Adriene M. Beltz
Volume 32, Issue 2, April 2011, Pages 183-200
A key question concerns the extent to which sexual differentiation of human behavior is influenced by sex hormones present during sensitive periods of development (organizational effects), as occurs in other mammalian species. The most important sensitive period has been considered to be prenatal, but there is increasing attention to puberty as another organizational period, with the possibility of decreasing sensitivity to sex hormones across the pubertal transition. In this paper, we review evidence that sex hormones present during the prenatal and pubertal periods produce permanent changes to behavior. There is good evidence that exposure to high levels of androgens during prenatal development results in masculinization of activity and occupational interests, sexual orientation, and some spatial abilities; prenatal androgens have a smaller effect on gender identity, and there is insufficient information about androgen effects on sex-linked behavior problems. There is little good evidence regarding long-lasting behavioral effects of pubertal hormones, but there is some suggestion that they influence gender identity and perhaps some sex-linked forms of psychopathology, and there are many opportunities to study this issue. © 2011 Elsevier Inc.
Sexual differentiation of the human brain: Relation to gender identity, sexual orientation and neuropsychiatric disordersAi Min Bao | Dick F. Swaab
Volume 32, Issue 2, April 2011, Pages 214-226
During the intrauterine period a testosterone surge masculinizes the fetal brain, whereas the absence of such a surge results in a feminine brain. As sexual differentiation of the brain takes place at a much later stage in development than sexual differentiation of the genitals, these two processes can be influenced independently of each other. Sex differences in cognition, gender identity (an individual's perception of their own sexual identity), sexual orientation (heterosexuality, homosexuality or bisexuality), and the risks of developing neuropsychiatric disorders are programmed into our brain during early development. There is no evidence that one's postnatal social environment plays a crucial role in gender identity or sexual orientation. We discuss the relationships between structural and functional sex differences of various brain areas and the way they change along with any changes in the supply of sex hormones on the one hand and sex differences in behavior in health and disease on the other. © 2011 Elsevier Inc.
The immune system and developmental programming of brain and behaviorStaci D. Bilbo | Jaclyn M. Schwarz
Volume 33, Issue 3, August 2012, Pages 267-286
The brain, endocrine, and immune systems are inextricably linked. Immune molecules have a powerful impact on neuroendocrine function, including hormone-behavior interactions, during health as well as sickness. Similarly, alterations in hormones, such as during stress, can powerfully impact immune function or reactivity. These functional shifts are evolved, adaptive responses that organize changes in behavior and mobilize immune resources, but can also lead to pathology or exacerbate disease if prolonged or exaggerated. The developing brain in particular is exquisitely sensitive to both endogenous and exogenous signals, and increasing evidence suggests the immune system has a critical role in brain development and associated behavioral outcomes for the life of the individual. Indeed, there are associations between many neuropsychiatric disorders and immune dysfunction, with a distinct etiology in neurodevelopment. The goal of this review is to describe the important role of the immune system during brain development, and to discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, mood and cognition. © 2012 Elsevier Inc.
Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegenerationRory D. Spence | Rhonda R. Voskuhl
Volume 33, Issue 1, January 2012, Pages 105-115
Multiple sclerosis (MS) is a disease characterized by inflammation and demyelination. Currently, the cause of MS is unknown. Experimental autoimmune encephalomyelitis (EAE) is the most common mouse model of MS. Treatments with the sex hormones, estrogens and androgens, are capable of offering disease protection during EAE and are currently being used in clinical trials of MS. Beyond endogenous estrogens and androgens, treatments with selective estrogen receptor modulators (SERMs) for estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) are also capable of providing disease protection. This protection includes, but is not limited to, prevention of clinical disease, reduction of CNS inflammation, protection against demyelination, and protection against axonal loss. In EAE, current efforts are focused on using conditional cell specific knockouts of sex hormone receptors to identify the in vivo targets of these estrogens and androgens as well as downstream molecules responsible for disease protection. © 2011 Elsevier Inc.
The genetics of sex differences in brain and behaviorTuck C. Ngun | Negar Ghahramani | Francisco J. Sánchez | Sven Bocklandt | Eric Vilain
Volume 32, Issue 2, April 2011, Pages 227-246
Biological differences between men and women contribute to many sex-specific illnesses and disorders. Historically, it was argued that such differences were largely, if not exclusively, due to gonadal hormone secretions. However, emerging research has shown that some differences are mediated by mechanisms other than the action of these hormone secretions and in particular by products of genes located on the X and Y chromosomes, which we refer to as direct genetic effects. This paper reviews the evidence for direct genetic effects in behavioral and brain sex differences. We highlight the 'four core genotypes' model and sex differences in the midbrain dopaminergic system, specifically focusing on the role of Sry. We also discuss novel research being done on unique populations including people attracted to the same sex and people with a cross-gender identity. As science continues to advance our understanding of biological sex differences, a new field is emerging that is aimed at better addressing the needs of both sexes: gender-based biology and medicine. Ultimately, the study of the biological basis for sex differences will improve healthcare for both men and women. © 2010 Elsevier Inc.
11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progressCaitlin S. Wyrwoll | Megan C. Holmes | Jonathan R. Seckl
Volume 32, Issue 3, August 2011, Pages 265-286
Glucocorticoids have profound effects on brain development and adult CNS function. Excess or insufficient glucocorticoids cause myriad abnormalities from development to ageing. The actions of glucocorticoids within cells are determined not only by blood steroid levels and target cell receptor density, but also by intracellular metabolism by 11β-hydroxysteroid dehydrogenases (11β-HSD). 11β-HSD1 regenerates active glucocorticoids from their inactive 11-keto derivatives and is widely expressed throughout the adult CNS. Elevated hippocampal and neocortical 11β-HSD1 is observed with ageing and causes cognitive decline; its deficiency prevents the emergence of cognitive defects with age. Conversely, 11β-HSD2 is a dehydrogenase, inactivating glucocorticoids. The major central effects of 11β-HSD2 occur in development, as expression of 11β-HSD2 is high in fetal brain and placenta. Deficient feto-placental 11β-HSD2 results in a life-long phenotype of anxiety and cardiometabolic disorders, consistent with early life glucocorticoid programming. © 2010 Elsevier Inc.
Cytokines and brain excitabilityMichael A. Galic | Kiarash Riazi | Quentin J. Pittman
Volume 33, Issue 1, January 2012, Pages 116-125
Cytokines are molecules secreted by peripheral immune cells, microglia, astrocytes and neurons in the central nervous system. Peripheral or central inflammation is characterized by an upregulation of cytokines and their receptors in the brain. Emerging evidence indicates that pro-inflammatory cytokines modulate brain excitability. Findings from both the clinical literature and from in vivo and in vitro laboratory studies suggest that cytokines can increase seizure susceptibility and may be involved in epileptogenesis. Cellular mechanisms that underlie these effects include upregulation of excitatory glutamatergic transmission and downregulation of inhibitory GABAergic transmission. © 2012 Elsevier Inc.
Gender differences in autoimmune diseaseS. T. Ngo | F. J. Steyn | P. A. McCombe
Volume 35, Issue 3, January 2014, Pages 347-369
Autoimmune diseases are a range of diseases in which the immune response to self-antigens results in damage or dysfunction of tissues. Autoimmune diseases can be systemic or can affect specific organs or body systems. For most autoimmune diseases there is a clear sex difference in prevalence, whereby females are generally more frequently affected than males. In this review, we consider gender differences in systemic and organ-specific autoimmune diseases, and we summarize human data that outlines the prevalence of common autoimmune diseases specific to adult males and females in countries commonly surveyed. We discuss possible mechanisms for sex specific differences including gender differences in immune response and organ vulnerability, reproductive capacity including pregnancy, sex hormones, genetic predisposition, parental inheritance, and epigenetics. Evidence demonstrates that gender has a significant influence on the development of autoimmune disease. Thus, considerations of gender should be at the forefront of all studies that attempt to define mechanisms that underpin autoimmune disease. © 2014.
Genes, hormones, and circuits: An integrative approach to study the evolution of social behaviorLauren A. O'Connell | Hans A. Hofmann
Volume 32, Issue 3, August 2011, Pages 320-335
Tremendous progress has been made in our understanding of the ultimate and proximate mechanisms underlying social behavior, yet an integrative evolutionary analysis of its underpinnings has been difficult. In this review, we propose that modern genomic approaches can facilitate such studies by integrating four approaches to brain and behavior studies: (1) animals face many challenges and opportunities that are ecologically and socially equivalent across species; (2) they respond with species-specific, yet quantifiable and comparable approach and avoidance behaviors; (3) these behaviors in turn are regulated by gene modules and neurochemical codes; and (4) these behaviors are governed by brain circuits such as the mesolimbic reward system and the social behavior network. For each approach, we discuss genomic and other studies that have shed light on various aspects of social behavior and its underpinnings and suggest promising avenues for future research into the evolution of neuroethological systems. © 2010 Elsevier Inc.
The role of NPY in hypothalamic mediated food intakeRebecca E. Mercer | Melissa J S Chee | William F. Colmers
Volume 32, Issue 4, October 2011, Pages 398-415
Neuropeptide Y (NPY) is a highly conserved neuropeptide with orexigenic actions in discrete hypothalamic nuclei that plays a role in regulating energy homeostasis. NPY signals via a family of high affinity receptors that mediate the widespread actions of NPY in all hypothalamic nuclei. These actions are also subject to tight, intricate regulation by numerous peripheral and central energy balance signals. The NPY system is embedded within a densely-redundant network designed to ensure stable energy homeostasis. This redundancy may underlie compensation for the loss of NPY or its receptors in germline knockouts, explaining why conventional knockouts of NPY or its receptors rarely yield a marked phenotypic change. We discuss insights into the hypothalamic role of NPY from studies of its physiological actions, responses to genetic manipulations and interactions with other energy balance signals. We conclude that numerous approaches must be employed to effectively study different aspects of NPY action. © 2011 Elsevier Inc.
Gonadal steroid hormones and the hypothalamo-pituitary-adrenal axisRobert J. Handa | Michael J. Weiser
Volume 35, Issue 2, January 2014, Pages 197-220
The hypothalamo-pituitary-adrenal (HPA) axis represents a complex neuroendocrine feedback loop controlling the secretion of adrenal glucocorticoid hormones. Central to its function is the paraventricular nucleus of the hypothalamus (PVN) where neurons expressing corticotropin releasing factor reside. These HPA motor neurons are a primary site of integration leading to graded endocrine responses to physical and psychological stressors. An important regulatory factor that must be considered, prior to generating an appropriate response is the animal's reproductive status. Thus, PVN neurons express androgen and estrogen receptors and receive input from sites that also express these receptors. Consequently, changes in reproduction and gonadal steroid levels modulate the stress response and this underlies sex differences in HPA axis function. This review examines the make up of the HPA axis and hypothalamo-pituitary-gonadal (HPG) axis and the interactions between the two that should be considered when exploring normal and pathological responses to environmental stressors. © 2013 Elsevier Inc.
Corticotropin releasing factor: A key role in the neurobiology of addictionEric P. Zorrilla | Marian L. Logrip | George F. Koob
Volume 35, Issue 2, January 2014, Pages 234-244
Drug addiction is a chronically relapsing disorder characterized by loss of control over intake and dysregulation of stress-related brain emotional systems. Since the discovery by Wylie Vale and his colleagues of corticotropin-releasing factor (CRF) and the structurally-related urocortins, CRF systems have emerged as mediators of the body's response to stress. Relatedly, CRF systems have a prominent role in driving addiction via actions in the central extended amygdala, producing anxiety-like behavior, reward deficits, excessive, compulsive-like drug self-administration and stress-induced reinstatement of drug seeking. CRF neuron activation in the medial prefrontal cortex may also contribute to the loss of control. Polymorphisms in CRF system molecules are associated with drug use phenotypes in humans, often in interaction with stress history. Drug discovery efforts have yielded brain-penetrant CRF1 antagonists with activity in preclinical models of addiction. The results support the hypothesis that brain CRF-CRF1 systems contribute to the etiology and maintenance of addiction. © 2014 Elsevier Inc.
Cytokine effects on the basal ganglia and dopamine function: The subcortical source of inflammatory malaiseJennifer C. Felger | Andrew H. Miller
Volume 33, Issue 3, August 2012, Pages 315-327
Data suggest that cytokines released during the inflammatory response target subcortical structures including the basal ganglia as well as dopamine function to acutely induce behavioral changes that support fighting infection and wound healing. However, chronic inflammation and exposure to inflammatory cytokines appears to lead to persisting alterations in the basal ganglia and dopamine function reflected by anhedonia, fatigue, and psychomotor slowing. Moreover, reduced neural responses to hedonic reward, decreased dopamine metabolites in the cerebrospinal fluid and increased presynaptic dopamine uptake and decreased turnover have been described. This multiplicity of changes in the basal ganglia and dopamine function suggest fundamental effects of inflammatory cytokines on dopamine synthesis, packaging, release and/or reuptake, which may sabotage and circumvent the efficacy of current treatment approaches. Thus, examination of the mechanisms by which cytokines alter the basal ganglia and dopamine function will yield novel insights into the treatment of cytokine-induced behavioral changes and inflammatory malaise. © 2012 Elsevier Inc.
Gonadotropin-releasing hormone (GnRH) neuron migration: Initiation, maintenance and cessation as critical steps to ensure normal reproductive functionMargaret E. Wierman | Katja Kiseljak-Vassiliades | Stuart Tobet
Volume 32, Issue 1, January 2011, Pages 43-52
GnRH neurons follow a carefully orchestrated journey from their birth in the olfactory placode area. Initially, they migrate along with the vomeronasal nerve into the brain at the cribriform plate, then progress caudally to sites within the hypothalamus where they halt and send projections to the median eminence to activate pituitary gonadotropes. Many factors controlling this precise journey have been elucidated by the silencing or over-expression of candidate genes in mouse models. Importantly, a number of these factors may not only play a role in normal physiology of the hypothalamic-pituitary-gonadal axis but also be mis-expressed to cause human disorders of GnRH deficiency, presenting as a failure to undergo normal pubertal development. This review outlines the current cadre of candidates thought to modulate GnRH neuronal migration. The further elucidation and characterization of these factors that impact GnRH neuron development may shed new light on human reproductive disorders and provide potential targets to develop new pro-fertility or contraceptive agents. © 2010.
Somatostatin receptors: From signaling to clinical practiceMarily Theodoropoulou | Günter K. Stalla
Volume 34, Issue 3, August 2013, Pages 228-252
Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an invaluable drug target for the pharmacological management of pituitary adenomas and neuroendocrine tumors. Somatostatin receptors (SSTR1, 2A and B, 3, 4 and 5) belong to the G protein coupled receptor family and have a wide expression pattern in both normal tissues and solid tumors. Investigating the function of each SSTR in several tumor types has provided a wealth of information about the common but also distinct signaling cascades that suppress tumor cell proliferation, survival and angiogenesis. This provided the rationale for developing multireceptor-targeted somatostatin analogs and combination therapies with signaling-targeted agents such as inhibitors of the mammalian (or mechanistic) target of rapamycin (mTOR). The ability of SSTR to internalize and the development of rabiolabeled somatostatin analogs have improved the diagnosis and treatment of neuroendocrine tumors. © 2013 Elsevier Inc.
Estrogen neuroprotection and the critical period hypothesisErin Scott | Quan Guang Zhang | Ruimin Wang | Ratna Vadlamudi | Darrell Brann
Volume 33, Issue 1, January 2012, Pages 85-104
17β-Estradiol (estradiol or E2) is implicated as a neuroprotective factor in a variety of neurodegenerative disorders. This review focuses on the mechanisms underlying E2 neuroprotection in cerebral ischemia, as well as emerging evidence from basic science and clinical studies, which suggests that there is a " critical period" for estradiol's beneficial effect in the brain. Potential mechanisms underlying the critical period are discussed, as are the neurological consequences of long-term E2 deprivation (LTED) in animals and in humans after natural menopause or surgical menopause. We also summarize the major clinical trials concerning postmenopausal hormone therapy (HT), comparing their outcomes with respect to cardiovascular and neurological disease and discussing their relevance to the critical period hypothesis. Finally, potential caveats, controversies and future directions for the field are highlighted and discussed throughout the review. © 2011 Elsevier Inc.
Control of GnRH secretion: One step backIain J. Clarke
Volume 32, Issue 3, August 2011, Pages 367-375
The reproductive system is controlled by gonadotropin releasing hormone (GnRH) secretion from the brain, which is finely modulated by a number of factors including gonadal sex steroids. GnRH cells do not express estrogen receptor α, but feedback is transmitted by neurons that are at least 'one step back' from the GnRH cells. Modulation by season, stress and nutrition are effected by neuronal pathways that converge on the GnRH cells. Kisspeptin and gonadotropin inhibitory hormone (GnIH) neurons are regulators of GnRH secretion, the former being a major conduit for transmission of sex steroid feedback. GnIH cells project to GnRH cells and may play a role in the seasonal changes in reproductive activity in sheep. GnIH also modulates the action of GnRH at the level of the pituitary gonadotrope. This review focuses on the role that kisspeptin and GnIH neurons play, as modulators that are 'one step back' from GnRH neurons. © 2011 Elsevier Inc.
Estradiol-dependent modulation of auditory processing and selectivity in songbirdsDonna Maney | Raphael Pinaud
Volume 32, Issue 3, August 2011, Pages 287-302
The steroid hormone estradiol plays an important role in reproductive development and behavior and modulates a wide array of physiological and cognitive processes. Recently, reports from several research groups have converged to show that estradiol also powerfully modulates sensory processing, specifically, the physiology of central auditory circuits in songbirds. These investigators have discovered that (1) behaviorally-relevant auditory experience rapidly increases estradiol levels in the auditory forebrain; (2) estradiol instantaneously enhances the responsiveness and coding efficiency of auditory neurons; (3) these changes are mediated by a non-genomic effect of brain-generated estradiol on the strength of inhibitory neurotransmission; and (4) estradiol regulates biochemical cascades that induce the expression of genes involved in synaptic plasticity. Together, these findings have established estradiol as a central regulator of auditory function and intensified the need to consider brain-based mechanisms, in addition to peripheral organ dysfunction, in hearing pathologies associated with estrogen deficiency. © 2010 Elsevier Inc.
Prenatal endocrine influences on sexual orientation and on sexually differentiated childhood behaviorMelissa Hines
Volume 32, Issue 2, April 2011, Pages 170-182
Both sexual orientation and sex-typical childhood behaviors, such as toy, playmate and activity preferences, show substantial sex differences, as well as substantial variability within each sex. In other species, behaviors that show sex differences are typically influenced by exposure to gonadal steroids, particularly testosterone and its metabolites, during early development (prenatally or neonatally). This article reviews the evidence regarding prenatal influences of gonadal steroids on human sexual orientation, as well as sex-typed childhood behaviors that predict subsequent sexual orientation. The evidence supports a role for prenatal testosterone exposure in the development of sex-typed interests in childhood, as well as in sexual orientation in later life, at least for some individuals. It appears, however, that other factors, in addition to hormones, play an important role in determining sexual orientation. These factors have not been well-characterized, but possibilities include direct genetic effects, and effects of maternal factors during pregnancy. Although a role for hormones during early development has been established, it also appears that there may be multiple pathways to a given sexual orientation outcome and some of these pathways may not involve hormones. © 2011 Elsevier Inc.
Sex differences in stress-related psychiatric disorders: Neurobiological perspectivesDebra A. Bangasser | Rita J. Valentino
Volume 35, Issue 3, January 2014, Pages 303-319
Stress is associated with the onset and severity of several psychiatric disorders that occur more frequently in women than men, including posttraumatic stress disorder (PTSD) and depression. Patients with these disorders present with dysregulation of several stress response systems, including the neuroendocrine response to stress, corticolimbic responses to negatively valenced stimuli, and hyperarousal. Thus, sex differences within their underlying circuitry may explain sex biases in disease prevalence. This review describes clinical studies that identify sex differences within the activity of these circuits, as well as preclinical studies that demonstrate cellular and molecular sex differences in stress responses systems. These studies reveal sex differences from the molecular to the systems level that increase endocrine, emotional, and arousal responses to stress in females. Exploring these sex differences is critical because this research can reveal the neurobiological underpinnings of vulnerability to stress-related psychiatric disorders and guide the development of novel pharmacotherapies. © 2014 Elsevier Inc.
The adrenal peripheral clock: Glucocorticoid and the circadian timing systemGi Hoon Son | Sooyoung Chung | Kyungjin Kim
Volume 32, Issue 4, October 2011, Pages 451-465
The mammalian circadian timing system is organized in a hierarchy, with the master clock residing in the suprachiasmatic nucleus (SCN) of the hypothalamus and subsidiary peripheral clocks in other brain regions as well as peripheral tissues. Since the local oscillators in most cells contain a similar molecular makeup to that in the central pacemaker, determining the role of the peripheral clocks in the regulation of rhythmic physiology and behavior is an important issue. Glucocorticoids (GCs) are a class of multi-functional adrenal steroid hormones, which exhibit a robust circadian rhythm, with a peak linked with the onset of the daily activity phase. It has long been believed that the production and secretion of GC is primarily governed through the hypothalamus-pituitary-adrenal (HPA) neuroendocrine axis in mammals. Growing evidence, however, strongly supports the notion that the periodicity of GC involves the integrated activity of multiple regulatory mechanisms related to circadian timing system along with the classical HPA neuroendocrine regulation. The adrenal-intrinsic oscillator as well as the central pacemaker plays a pivotal role in its rhythmicity. GC influences numerous biological processes, such as metabolic, cardiovascular, immune and even higher brain functions, and also acts as a resetting signal for the ubiquitous peripheral clocks, suggesting its importance in harmonizing circadian physiology and behavior. In this review, we will therefore focus on the recent advances in our understanding of the circadian regulation of adrenal GC and its functional relevance. © 2011 Elsevier Inc.


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Ferry system settles suit
A three-year battle ended Tuesday as Washington State Ferries announced a $4.4 million lawsuit settlement with Rich Passage-area property owners, who claimed the fast ferries seriously damaged their properties and the neighborhood ecosystem.
Were certainly happy its over, said Doug Waddell, spokesman-elect for the plaintiffs.
Waddell, who lives on waterfront property just outside Port Orchard, said damage started from the first moment the Chinook WSFs first high-speed catamaran started making runs between Bremerton and Seattle in May, 1998. He and other coastal inhabitants watched as their beaches washed away and the wildlife which frequented the shoreline slowly vanished.
Although the Chinook, and its sister-ship the Snohomish, were designed to be nearly wakeless, Waddell said the design was useless in a waterway like Rich Passage. The slope of the inlets sea floor and the funnel-shape of the passage, he said, amplified what little wake the boat did produce, causing huge breakers to form and batter the shorelines on either side.
According to the lawsuit documents, wash from the Chinook alone could create waves 12 feet high as it struck shoreline bulkheads. Waddell said a video was made of this phenomenon, and said several people who watched it compared the waves to ones they had previously seen in Hawaii a state famous for its challenging surf.
They really did scare a lot of children around there, Waddell said, echoing the lawsuits claims that small children were in danger of being swept off the beach by these waves. If you havent seen the video, you wouldnt believe it.
Although the lawsuit asked for monetary damages and cited loss of property as one of the bases for the suit, Waddell said money was not the primary object behind the legal battle. He said the other charges, involving environmental impact, were more important than property devaluation caused by beach loss.
The first two charges allege WSF violated the Shorelines Management Act and the state Environmental Policy Act by engaging in activity operating boats that destroyed shellfish and kelp beds and eroded natural shoreline. Waddell said when he first moved into his current home in 1996, he could watch salmon feeding from his backyard and often was visited by cranes and eagles, which relied on the Rich Passage tide flats as a food source.
Some of my damages, you cant put a monetary value on, he said. It was almost like living in an aquarium out here, but its all gone. (The wake) killed off all the marine growth, and it hasnt come back. I dont know if it will ever come back.
The settlement will pay damages to the 113 specific property owners who responded to a state inquiry regarding the extent of damage. The original lawsuit named any property owner who suffered loss as a result of the boat wake, which amounted to 284 people. However, the courts found this class to be too broad and trimmed it down.
The final list still includes people who own property not only on Rich Passage, but all along Sinclair Inlet from Port Orchard to Wautauga Beach north of Manchester, from Bremerton to Bainbridge Island.
Many of the specified property owners joined the Shoreline Conservation Alliance, a legal body set up to help direct and fund the suit. Waddell said members assessed their own properties numerous times to pay the lawsuits bills. Although the lawyers retained worked on contingency, Waddell said the property owners had to pay for their own expert witnesses and research.
We had to counter every claim the power of the state had, he said. That got expensive.
The lawsuit gives the property owners the right to sue again if they feel their concerns have not been addressed by WSF. However, Waddell said one three-year lawsuit was more than enough for most people. Many people, including two of the four litigants actually listed in the suit, sold their properties and left before the settlement was reached.
We were all amateurs at this, Waddell said. Had we had any clue this would go this long, we would have said: To heck with it were moving.
Theres still some hoops to be jumped through before the litigants get their checks.
Sean Matt, the coordinating attorney on the case, said the settlement, including the breakdown of individual cash awards, must first be approved by the court. After nearly $350,000 in upfront cash investment mostly money paid to expert witnesses is reimbursed and the plaintiffs lawyers get a negotiated 25 percent cut, approximately $3.1 million is left to be distributed among the 113 class members.
Matt said the money will be divided in accordance with how much property damage each individual claimant sustained, an amount established by an engineer specializing in shoreline maintenance.
You have some stretches of shoreline in that area that sustained very little impact, Matt said. Some people sustained more damage than others. (However,) the highest dollar claims are going to be from the people with the most shoreline.
After a 30-day comment period and a final seal of approval from the courts, WSF will write a check for the amount in trust of Matts law office Seattle-based Hagens Berman.
If all goes as planned, Matt said, the class members should be getting their checks by late June.
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Young baseball players can refine their hitting skills with the Lightning Bolt Pro Soft Micro Ball Pitching Machine. Instead of regular baseballs, this pitching machine comes with 12 foam micro balls. (It can hold up to 26.) Load the balls into the shagger, adjust the height for different pitching locations, and turn it on. This machine automatically pitches soft practice balls 30 miles per hour up to 25 feet. There is a five second delay between pitches to give solid repetition training. When you're done, the shagger detaches and can be used to pick up the micro balls by just placing it on top of a ball and pushing down. The ball will then go inside the shagger, so you don't have to bend over and pick up each ball.
We like the small balls with this automatic pitching machine because once you get adjusted to hitting them, hitting a baseball, softball, or wiffle ball becomes a lot easier.
The Lightning Bolt Pro is not age-graded, but we feel that it is appropriate for any baseball player ages 5 and up who wants to refine their hitting skills.
Six C batteries are required but not included. This also comes with an AC adapter, however, if you are playing with this outside, chances are there will not be a wall outlet to plug it into.
Generally, the first ball that comes out of the pitching machine will be a grounder. But the second ball will be at the correct height you want.
6 C batteries required
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Junk Ball Light Up Bat and Ball
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Trick Pitch Baseball
from Day6 Sports Group
Batapult Jr
from OGO Sport


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The Fallen 1; The Fallen 2; The Fallen 3The first three volumes in the New York Times bestselling The Fallen series is available as an eBook boxed set. Join the ultimate quest for redemption.The son of a mortal and an angel, Aaron has been chosen to redeem the Fallen. But as war rages between Heaven and Hell, evil powers gain strength at every turn. Aaron must harness the incredible force within him if he's going to save himself and the
Fallen (Book 1)Aaron Corbet isn't a bad kid -- he's just a little different. archangel On the eve of his eighteenth birthday, Aaron dreams of a darkly violent landscape. He can hear the sounds of weapons clanging, the screams of the stricken, and another sound he cannot quite decipher. But gazing upward at the sky, he suddenly understands. It is the sound of great wings, angels' wings, beating the air
Fallen (Book 1)Aaron Corbet isn't a bad kid—he's just a little different. And starting on the eve of his eighteenth birthday, Aaron begins to discover supernatural talents. Then he learns the truth about his destiny: He must unite angels, mortals, and Powers both good and evil, some of whom are hell-bent on his destruction.... The Fallen quartet, now published for the first time in two action-packed bind-ups,
Fallen (Book 2)Destined for Heaven or Hell? The saga continues from THE FALLEN 1.Aaron's senior year has been anything but typical. Half-angel and half-human, he has been charged to reunite the Fallen with Heaven. But the leader of the Dark Powers is determined to destroy Aaron—and all hope of angelic reconciliation. Struggling to harness the incredible force within him, Aaron trains for the ultimate battle.
Fallen (Book 3)Victory is fleeting, but defeat is eternal.The war between Heaven and Hell rages on. Aaron, half-angel and half-human, commands the Fallen in their quest to protect humanity. But evil forces gain strength at every turn. And lurking somewhere in the shadows is Archangel Gabriel's instrument with the power to call down the End of Days.Aaron draws confidence from the girl he loves as he struggles to
$5.99From four of today's hottest fantasy authors—all-new novellas of dark nights, cruel cities, and paranormal P.I.s.View our feature on Mean Streets.The best paranormal private investigators have been brought together in a single volume—and cases don't come any harder than this. New York Times bestselling author Jim Butcher delivers a hard-boiled tale in which Harry Dresden's latest case may be his
A Remy Chandler Novel (Book 1)Generations ago, angel Remiel chose to renounce heaven and live on Earth. He found a place among ordinary humans by converting himself into Boston P.I. Remy Chandler, but he can never tell anyone who he was or that he still has angelic powers. Remy can will himself invisible, speak and understand any foreign language (including any animal language), and hear the thoughts of others. All these
A Remy Chandler Novel (Book 3)Six year-old Zoe York has been taken and her mother has come to Remy for help. She shows him crude, childlike drawings that she claims are Zoe's visions of the future, everything leading up to her abduction, and some beyond. Like the picture of a man with wings who would come and save her-a man who is an angel. Zoe's preternatural gifts have made her a target for those who wish to exploit her
A Remy Chandler Novel (Book 4)Once he was known as the angel Remiel, but generations ago Boston PI Remy Chandler chose to renounce Heaven and live on Earth, where he found a secure place among us ordinary humans…As an Angel, Remy Chandler possesses powers and skills he puts to good use in his chosen profession—but only if the situation calls for it. And the sudden reappearance of the Garden of Eden is definitely one such
Fallen (Book 4)Half angel and half human, Aaron holds the weight of the world in his hands in the fourth book of the New York Times bestselling The Fallen series.The war between Heaven and Hell rages on. The devil has possessed Lucifer's body and is intent on unleashing unfathomable chaos in the world. But no matter the cost, Aaron and the other Nephilim are determined to protect humanity. As the casualties
A Remy Chandler Novel (Book 2)Remy Chandler ?is a character I can?t wait to see again.?( Christopher Golden, bestselling author of The Lost Ones) Still mourning the loss of his wife, fallen angel Remy Chandler has immersed himself in investigating dangerous supernatural cases. His latest: the theft of a cache of ancient weaponry stolen from a collector who deals in antiquities of a dark and dubious nature. The weapons, Remy
Fallen (Book 5)Only Aaron and his fellow Nephilim can protect the world from Satan's wrath in this riveting finale to the New York Times bestselling The Fallen series.Satan is determined to create his own Hell on Earth and has unleashed unfathomable chaos into the world. Cut off from Heaven, humanity's only hope for salvation rests with eighteen-year-old Aaron and the other Nephilim who fight by his side. These


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Mecklenburg's Consistent
Thank you District 6 voters for re-electing me with 63.01% of the vote ! 11,641 votes versus 6,833 for my opponent is a resounding victory for conservative leadership in District 6. I will continue to work to be your consistent conservative voice on the Mecklenburg County Commission. Thanks again for all your help.
Commissioner Bill James is a
Conservative Republican member of
the Mecklenburg County Board of
Commissioners in Charlotte, NC. He
represents approximately 167,000
people in Southern Mecklenburg
including the Towns of Matthews,
Mint Hill and Pineville. You can
read more info on Mecklenburg
County's web site
here. A summary of his past
political campaigns can be found
Tweets by @meckcommish
Copyright 1999-2016 by Commissioner Bill James


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A Study on the Behavior of MANET Routing Protocols with Varying Densities and Dynamic Mobility Patterns
Mobility and node density are the two major factors which has much influence on the performance of any routing protocol of mobile ad hoc network. Several previous works highlighted this fact. This paper will evaluates some of the widely used MANET routing protocols with different mobility and network density. The proposed evaluation will be made on MANET routing protocols DSDV, DSR and AODV which are readily available in network simulator-ns2. The performance of these protocols will be measured with suitable metrics.
Provided by: International Journal of Computer Applications Topic: Mobility Date Added: Dec 2010 Format: PDF


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Published 27/11/2012 | 10:09
Donations are already flowing in for a fund to pay for extensive work on the organ at St.
Published 27/11/2012 | 10:09
Donations are already flowing in for a fund to pay for extensive work on the organ at St.
Fintan Lambe St Aidan's Church in Ferns was filled to capacity recently as people from across the diocese gathered for the eighth annual St. Padre Pio Healing Mass.
Fintan Lambe Do you enjoy singing? Why not go along to one of Enniscorthy Gospel Choir's Rehearsals and see what they do?
Fintan Lambe Three works by the late Michael E Morrison of Ballintore, Ferns, have been published posthumously in one volume titled 'The Legacy' which will be launched by Wexford boxing legend Billy Walsh at the Fr...
A new website which outlines a range of services... News
It was one of those calm Sunday afternoon's in autumn that usually drifts by without a care... News
There were great... News
Pensioner Paddy Kelly got... News
If Hillary Clinton succeeds in her bid to shatter the glass ceiling and take the White House... News
Two raiders fled a house at Foxhill, Clonattin, Gorey, last Tuesday night, after they were disturbed by the householder. News
The year kicked off in FCJ Secondary School Bunclody with the annual beginning... News
Memories of homework,... News
The outstanding efforts of FCJ Bunclody in the fight... News
Ferns GAA club is on a mission - a mission to get people more active and maybe even... News


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The Oregon School Activities Association has announced that Peter Weber will be its next executive director, succeeding Tom Welter, who is retiring effective July 31.
The release from the OSAA:
Peter Weber will be the next executive director of the Oregon School Activities Association.
Weber was appointed by the OSAA Executive Board following the announcement earlier this week that current executive director Tom Welter will retire July 31.
A member of the 12-person, Wilsonville-based OSAA staff since 1999, Weber has served as an Assistant Executive Director for the past nine years. Previously he was the Association's Public Relations Director.
"I sincerely appreciate the opportunity to serve the entire Association as the Executive Director," Weber said. "I look forward to working closely with the Executive Board, current staff and our member schools as we continue our efforts to provide positive experiences for students throughout Oregon."
Weber, 42, has worked extensively with rule interpretations and coordinated state championships for soccer, speech, golf and baseball. He has served as staff liaison to and coordinated OSAA Classification & Districting and Rankings Committees.
"We deeply appreciate the work Tom Welter has done during his tenure for high school activities in Oregon, but we are also extremely pleased Peter Weber will be the OSAA's next Executive Director," said Andy Gardner, president of the OSAA Executive Board. "Peter's work with the many school and stakeholder groups has left a strong impression of a highly professional and ethical person, one who will advance the ideals of the Association."
"The unanimous vote of support by the OSAA Executive Board to elect Peter Weber to the Executive Director position will provide the organization and member schools a seamless transition," added board vice president Don Grotting. "Peter is truly a great advocate for all student activities, while also understanding the differences and needs of our diverse member schools."
During his 17-year, OSAA career, Weber has overseen advancements in the association's website and the development of a rankings formula to draw playoff brackets. He has an expert understanding of OSAA Handbook rules and policies having served as the publication's editor.
Prior to the OSAA, Weber was director of alumni and public relations at Central Catholic HS in Portland, his alma mater. Weber attended St. Mary's College in Moraga where he graduated cum laude with a B.A. in communications in 1995.


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Hello BCW. Welcome on earth. Rock on cute little guy.
Basic obstacle avoidance robot using two servos for the wheels(lids from dog food), the caster is a funny plastic bolt cap they use in NYC on construction sites(found on street), Foam board, hot glue and the Arduino from yourduino.com with servo plug ins and last but not least the HCsr04 :D
More to come on this one. Been wanting to post this little guy for a few weeks and have not had a chance. BOX CAR WILLY 1.0 :D
Update- 12/19/2012
BCW has three cell phone batteries powering him and I have set it up for easy charging...well kinda easy. :)
I added two switches, one for movement(placed higher for easy stopping) and one for the Arduino.
New Caster also!
Could not bring myself to post a full robot just for a RocketBrand BristleBot :D so I combined BCW's update and BristleBot in one video! Gotta love the Extra WiiCamera Parts Chris the Carpenter sends with it!
BCW is getting a new shell/armor made of Styrene :D Here are a few pics just for fun.
3/3/13 update - Body work
As CTC would say "lil putty llil paint make it what it ain't"
I went with Silver!
Hello BCW. Welcome on earth. Rock on cute little guy.
hi chief! this looks awesome and creative(dog food lids!!!...i'm thinking of chief :) )
Hey chiefdadddy. This robot looks pretty good. Styrene is my prefered material to work with.


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Financial Etiquette: What to Say When Someone Asks How Much Something Cost [VIDEO]
It's been said that money is one of the last conversational taboos – but that doesn't mean your brother-in-law won't ask you the sticker price of your new car.
In our latest episode of "Financial Etiquette with Randy Cohen," the author, humorist and original The New York Times "Ethicist" gives his advice on how to handle the "How much did that set you back?" question.
Financial Etiquette with Randy Cohen has caught the attention of publications like The Wall Street Journal, The New York Observer, and The Salt Lake Tribune. For more "Financial Etiquette with Randy Cohen," click here, or visit us on Facebook or YouTube.
What do you say when someone asks you how much you paid for something? Is there ever a time when you feel comfortable sharing the price?
Links to non-Ally websitesWe provide links to third-party websites for your convenience. Although we provide a link, Ally Financial is not responsible, nor can we guarantee their products, services, or information. We suggest you review their online policy and security practices to learn about this third party and how they handle consumer information.


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BVCC is available for hire to groups & individuals requring a venue to hold activities, meetings and even exhibitions or displays over weekends.
It is with great pleasure that we welcome this folk,roots & contemporary acoustic Music on the Road Festival to Balgownie. The concert will be held in the main hall on Friday 1 April at 6.30pm. Music will be from an international and Australian folk groups. Ticket sales are through www.festivalofsmallhalls.com
Come board the bus for a fun day out to the Southern Highlands wineries on Saturday 9 April. We will be visiting 3 wineries and stopping in Bowral for lunch ( at your own expense). Cost for the bus only is $65.00.
Bookings are essential by phoning the office on 42853225 or email email@example.com. So- get your friends together and come with us!
2016 date to be confirmed.
Come along to find out what goes on in your community centre.
Be part of the planning for the future direction of the centre or just get information on what's on in 2016-17
The meeting will be in the CWA Room - this is the building at the rear of the main hall and accessed via the gate on the western side.


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We don't know how many terror plots this information has saved us from.
Well the Russians warned them about the Boston attack....that doesn't speak well as to their abilities....they seem more concerned with going after tea partiers than our real enemies.
Because the NSA and other alphabet soup organizations are no lomger used to "keep us safe" as much as they are being used to control us and anyone who dares speak against their master.
Your comment inferring that obama's lackeys in the military, DHS, CIA, FBI, DOJ and IRS want to keep us safe is laughable.
These people are about money, power, control , career or a combination thereof.
They are all corrupt to the core, and Benzghazi and F&F are clear evidence to validate my points.


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Frenchman Richard Sainct claimed the third Dakar Rally victory of his career today. Sainct took victory by over seven minutes over fellow Frenchman Cyril Despres, with defending race champion Fabrizio Meoni finishing some 30 minutes behind in third place.
Despite finishing second Despres was never really a factor as this Dakar Rally was really between Sainct and Meoni. Still, Despres took the runnerup spot despite breaking his collarbone just four weeks prior to the start of the rally.
Meoni had transmission problems as he tried to win the final stage today, his KTM stuck in third gear on the high-speed run to the finish.


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27 years of experience
Accepting new patients
Southside Womens Center
5920 Saratoga Blvd
Corpus Christi, TX 78414 Phone number & directions
Patient Reviews
Patient Reviews ? Write a Review
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Dr. Khimani is a horrible dr. I would NEVER see her again nor would I ever recommend her to anyone. I saw her for my 4th pregnancy. she didn't do any labs to even confirm I was pregnant, not even a sono. I went back 2 wks later for a sono & the baby showed to be 5wks less in measurements than it should have & there was no heartbeat. I stressed my concern. yet she said there was nothing to worry about. I asked for labs to check my hcg levels bc I knew something was wrong & still she denied me that. sure enough the next day I began bleeding & went to ER where they did lab work to confirm my hcg level was low. 2 days later I was back at ER & passed my baby. I carried around my dead baby for wks not even knowing something was wrong bc she never did lab or cared to listen to my concern. I know my body better than she did & still she paid no mind to my worry. I will NEVER see her again!! this wasn't only my life she was suppose to be caring for but my unborn child's as well
The office environment is not so great, very old and very uncomfortable seating. A VERY LONG WAIT TIME TO BE SEEN! The staff ladies are not so nice, if you have a question you have to leave a voicemail to the doctors nurse which typically doesn't get back to you and if you're lucky she will call you back within 3-4 days of leaving the message. The doctor is nice the only problem I had with her was that I was very sick with the flu and she had told me if I go sick to come to her office, well I got very sick on Friday my husband wanted to take me to an ER clinic but I said no since the doctor had said to go see her, so I waited until Monday to call and when I called they couldn't get me in as a walk in, after fighting to get seen since I was very sick the doctor finally agreed to see me and I drove an hour and a half to the doctors office, when I got there I waited for the longest time to be seen, when she finally saw me she didn't exam me or check my throat, fever, anything, she simply gave me a prescription, I was very upset and so was my husband she could have just sent the prescription to our local pharmacy if she knew what I had and what she was going to prescribe me. The second incident I had was when I said I've had it here, Im going to another obgyn. We we're scheduled for our gender reveal ultrasound on Friday, we had a family emergency and we had to leave that Wednesday, so I called Monday to see if I could get seen sooner but they had no availabilty, so I requested to get a prescription for an ultrasound at the hospital next door that could see me sooner, however the doctor didn't want me to do that because she wanted all the measurements of the baby, I called the hospital and they said they would send all that info over to her, so I called back and the doctor said no again, I asked if I had it done would she be in the room with me and she said no, so it made no difference where I had it done. Since her office has a private ultrasound, my husband thought perhaps she just wanted to get the money for the insurance instead of the hospital getting it if I did it thru them. We also felt that she made me go into see her when I was sick only for collecting the insurance money since she didn't even exam me. Overall I wouldn't recommend this doctor or the other doctor in her facility, bad experience over all.


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Monthly Archives: December 2009
PDA: A Look into the Worship Habit of Mary of Bethany
Mary's first recorded act of PDA occurs in a famous scene where many modern books and biblestudies tisk-tisk Mary's sister Martha for being hospitable, and perhaps a bit of a bossy older sister. But nevermind that. Sitting at the Lord's feet is public worship, is slightly scandalous, and is perhaps what enabled Mary to understand Jesus' predictions of his death—and what partly motivated her to exhibit her next recorded public display of affection: breaking the very expensive jar of perfume to anoint her Lord's head and feet. Continue reading


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The Mobile area is loaded with D-I players in the 2008 class including Vigor High School, which features at least two top prospects headlined by athlete Burton Scott.
Burton Scott headlines talented Vigor squad
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Panzou Project Inc
Rating: 4.92 stars 25 25 reviews
% Laura Kallus 1541 Ne 167TH St N Miami Beach FL 33162 USA
Our mission is to prevent gang & youth violence by offering our youth a vision of change and the tools to make those changes in their lives and communities!
PanZOu has changed the lives of hundreds of young people and their families since 2004. Most of our clients are multiple offenders who began their criminal activies while still a juvenile. We have an 88% success rate in keeping our clients from offending or re-offending while in our program! As validation of our success, PanZOu received a 2005 Coordination Award from the National Weed and Seed Strategy, 2007 Angels Among Us Award from Department of Children & Families, 2009 Gang Violence Prevention Award from the US Attorney's Office Project Safe Neighborhoods Initiative and has been highlighted by the Attorney General as a model program for his Gang Reduction Strategy 2009-2012. As well, OJJDP recognized the PanZOu Project in its Best Practices to Address Community Gang Problems: OJJDP's Comprehensive Gang Model (2008). The Urban Institute's recent interim evaluation report on our program described our experience and capability implementing and managing such an effort as: "One of the strengths of the North Miami Beach GRP has been its organizational capacity and leadership… to bring together a diverse yet collaborative and cooperative group of partners who worked to ensure full implementation of the GRP model. The collaborative functioning within the committee has continued and expanded over time, and the building of such a collaborative partnership has been one of the site's most important accomplishments" Community Collaborative Addressing Youth Gangs: Interim Findings from the Gang Reduction Program (May 2008).
Direct beneficiaries per year:
Over 100 youth AND their families
Geographic areas served:
Miami Dade County
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Reviews for Panzou Project Inc
The Panzou Project is a great asset to the crime fighting abilities of the North Miami Beach Police Department and is an integral part of of local gang prevention and intervention efforts. We have partnered with Panzou for many years and support it wholeheartedly!
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I've personally experienced the results of this organization in...
Our personal experience with this group has been outstanding!
If I had to make changes to this organization, I would...
This organization has the capacity to provide quality services to young people - offering them a way to out of violence. The amazing thing is, it does it with heart and soul and on a shoe-string budget.
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I've personally experienced the results of this organization in...
If I had to make changes to this organization, I would...
build its capacity to generate funds through the sale of t-shirts designed and made by clients.
The representatives with this program work with some of our population and they are phenomenal. They truly move mountains for their clients.
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I've personally experienced the results of this organization in...
If I had to make changes to this organization, I would...
I also work in the field of prevention/intervention programs and cannot overstate the importance of this program to our inner-city youth. So many people give up on these youth without ever trying to understand why they become who they become or how we can help to rectify our community short-comings in not being there for these kids. These youth grow up in circumstances that no child should have to know or experience and yet they are survivors and somehow manage to survive poverty; fatherless homes; dysfunctional homes; violent schools and neighborhoods, fierce peer pressure; no support and no resources. PanZou Project is there to help them when no one else is. Bravo PanZou and brava Laura Kallus!
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I've personally experienced the results of this organization in...
Yes, PanZou and Empowred Youth work in community partnership and server the same youth.
If I had to make changes to this organization, I would...
Give them the opportunity to grow and help more youth.
As the IT Regional Director for the Department of Juvenile Justice I have followed the progress of the PANZOU project through out the years. They have without a doubt a professional staff that has a true passion for helping Floridas youth. But no organization can have the success as well as the impact that the PANZOU project has had without a great leader. Mr. Kallus has been instrumental in their success and along with her constant motivation to help our kids mixed in with a passionate staff and a well design program this is the perfect recipe for success. I expect nothing but the best from them know and in the future.
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I've personally experienced the results of this organization in...
My role has been more on the technical side of the equation.
If I had to make changes to this organization, I would...
There is always room for change specially in these hard times. PANZOU has adapted very well and have no problem with restructure. They have clearly demostrated this. To my opinion I wiould not change anything at this point.
How does this organization compare with others in the same sector?
Very Well
How much of an impact do you think this organization has?
A lot
Will you recommend this organization to others?
What is unique about this organization?
Their staff and their outlook towards troubled youths
When was your last experience with this nonprofit?
8 people found this review helpful
I have been apart of the PanZOu family since 2004. What attracted me to this wonderful program was its desire to provide direct services to Haitian youth in our community at-risk gang and youth violence. As a Haitian-American professional, I knew that this population needed these direct services and wanted to be apart of the movement. I have seen firsthand the love and support PanZOu staff give to its clients. Whether it is being in the delivery room when a client is alone giving birth to their first child or digging deep into our wallets to provide our clients with a safe spring break that includes camping in the wood to tours of local universities to see what they have to offer. PanZOu works everyday to continue encouraging our youth to starve for the best in life and most importantly to dream of a future. PanZOu is a place where all we provide is free of charge and I hope that we can continue to provide our services for years to come!
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If this organization had 10 million bucks, it could...
continue to provide mentors to local youths who encourage them to stay out of trouble. with that kind of money, PanZOu would work to build a state of the art Drop-in center that provides free commputers labs, tutoring and a game room!
How frequently have you been involved with the organization?
About every week
When was your last experience with this nonprofit?


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Winter Fling, Ale brewing and Milwaukee's The Moth postponed tonight
First the Milwaukee Art Museum closed for the day. Now the weather has claimed a few more events.
The Exotics Winter Fling at Hotel Foster has been postponed. So put down the shorts and repack that bikini. Here's the Facebook post announcing the change in date. »Read Full Article
Tame Impala anything but at Turner Hall show
Kevin Parker's perfectionist tendencies went into overdrive on last year's "Lonerism," psychedelic band Tame Impala's sophomore full-length album. Besides insisting on playing nearly all the instruments in the studio, Parker mixed the album two times, flying from his native Australia to New York on both occasions, to get the details just to his liking.
Tame Impala didn't have the luxury of do-overs and fine tuning in its sold-out, 85-minute Turner Hall Ballroom set Sunday. And if Parker attempted to bring that obsessive craftsmanship to a live setting, he would run the risk of sabotaging the set's potential for spontaneity. »Read Full Article(1)
'Rep Lab' cooks up mixed batch of one-acts
In her curtain speech before Saturday night's sold-out performance of "Rep Lab," Sandy Ernst - who oversees the Milwaukee Repertory Theater's justly acclaimed intern program - made clear that the Rep simply couldn't stage its shows without each year's crop of two dozen interns.
But even as we routinely note these interns' presence - in smaller roles, as extras and in program credits, where they are listed as understudies and assistants - we rarely get to really see what they can do. Now in its third year, "Rep Lab" - short plays showcasing intern actors, directors, choreographers and designers - lets us appreciate how good they can be. »Read Full Article
Report: Fallon to replace Leno
Reports have surfaced that late-night host Jimmy Fallon will replace Jay Leno as host of "The Tonight Show" show next year.
NBC, which just finished fifth behind Univision in the February ratings, has denied the report. »Read Full Blog Post(6)


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Other reviews relating to this order
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Lily's Florist
| It was very quick and easy to purchase the flowers online and the website was really simple to navigate. Only suggestion - I had to just assume that my order had been delivered. It would have been really awesome to have received a notification to confirm that the flowers had been delivered (email / sms). This is the only reason I rated this "good" and not "excellent" - everything else was great thank you :)


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Corvette Shifter 6 Speed Bushing Repair Kit
The OEM rubber bushings on the Corvette manual shifter boxes often need replacement after only a few thousand miles. The symptom is excessive or sloppy shift lever movement and difficulty in up shift/down shift, excessive vibration or rattling of the shift knob. Our bushings are a tighter fit so they do a much better job of managing the vibration harmonics in the shifter assembly which results in the shifter rattle. As you have learned, its all about managing the harmonics between the torque tube and the shifter box, shifter assembly, and knob.
Kit includes:
GM does not sell just the bushing...you have to buy an new OEM shifter assembly, until now! We have sold hundreds of the bushings so far, with 100% customer satisfaction.
Customer Testimonial:
"I use these bushings in my 2005 Corvette and it shifts great without any rattle or excessive vibration. Dont worry about the round shape. They fit the elongated shifter box hole and the metal stand-off."


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As we approach the All-Star break, it's time to take a look back at the first half of the season and hand out some mid-season awards to the Pittsburgh Pirates.
After a very solid first half of the season, giving proper recognition to these young Bucs was much tougher than usual. Several members of the 2011 squad are having good enough seasons to be recognized.
With that being said, let's jump right into the awards.


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Favorite Dish Sausage platter for two 23 euros. This came with fresh baked bread with smoked pork inside it - very nice. Nice range of local sausages with very decent sauerkraut and potaoes. This was adequate for two and very tasty. We despatched the red currant sauce and mustard but did not make use of the ketchup. Beer was 3.60 euros (4 in the square and 2.8 a few streets further back). Lovely wooden furnture and decor. We sat by a log fire. Staff in local costume. They were incredibly polite and helpful and delighted when we tried out a little Estonian. I'd go again to try a different dish.
I have read numerous good reviews of this restaurant ( which made me want to try it ). this review is not one of those
I ordered what was described on the menu as " thick pea soup " - what I got was something that resembled a type of watery broth with barley, carrotts , onion and yes peas ( but of the chick variety ). To say that I was disappointed would be an understatement.
Being in a restaurant that served typical Estonian food I decided to try something different for my main meal and opted for the wild boar with mushroom sauce. disappointment again - it arrived in what can only be described as a thick mushroom stew.
If only my pea soup was that thick
For the curious amongst you I cannot tell you what wild boar tastes like because its taste was completely masked by the mushroom sauce.
The waitress service - can be summed up by what follows :-
My brother in law also ordered the boar' but his came with an added extra in the form of the bullet that killed it. Take it from me this was no small pellet, it was at least the size of a marble, which he nearly swallowed. Naturally he pointed this out to a very dimissive waitress whose only comment was " It's a wild animal what do you expect " .
On asking to speak to the manager she said that he did not work on a Friday night and that was that".
We then asked if we could speak to the chef and this was also refused. All we wanted was a simple sorry it should not have happened and that would have been the end of the matter.
From that moment on she never came near our table other than to give us the bill.
Favorite Dish See above
The name of this Estonian restaurant is translated into English as the 'Golden Piglet Inn'. This is quite apt given the amount of pork on the menu and the cute piggy planters that adorn the windows (see photo). The food here is a good introduction to Estonian cuisine- very simple, fresh ingredients with little seasoning. Some may find it bland, some may find it a little heavy, but as I consider it a necessity to at least try some local food when visiting new places, this restaurant fit the bill very well. After eating here, I cannot say that I am a huge fan of Estonian food but the polite staff and pleasant location made this meal a memorable one.
Favorite Dish I ordered pork chops with new potatoes and sauerkraut. While waiting for the main course, I was brought some bread with bacon bits in it which was quite tasty. The meal itself was hearty and filling. Simple food cooked well.
An Estonian country inn in the centre of Tallin, this restaurant is apparently very popular with local diners. It certainly was when we were there. This not cheap, but reasonably priced restaurant, has a menu with lots of choices. I had chicken coated in dark bread crumbs, potatoes and cabbage salad; my wife had roast pork with potatoes and sauekraut. The waitresses wore traditional Estonian dress - and so did the waiters, except for the waistcoats which were Royal Stewart tartan! One waiter explained that this was the closest they could find to the traditional pattern he showed me from an old book.
Favorite Dish Everything looked delicious.
The name in English is the Golden Piglet Inn. Vegetarians beware! You might even find pork in the bread unless you are very careful. The cooks even put bacon in the bread!
The staff have traditional costumes and around the restaurant there are baskets of artifical / dried fruit and flowers and old artefacts to give an air of Estonian country life.
Favorite Dish For starters I had the hot pork on black bread with pickles and sauces - a cranberry one and one with a hint of garlic. The pork was cooked to perfection.
For main course I was tempted by the vegetarian offering of a mushroom and potato stew. As a meat eater I was quite content to opt for such a tasty meatless option. The initial menu might put off vegetarians but I would recommend a trip there for this dish alone.
Desserts were too tempting even though I had eaten a cake just a few hours earlier. The meringue that I had was light and fluffy which took the edge off the berries it came served with.
We washed everything down with an incredibly cheap bootle of Ukrainian champagne. Usually I wouldn't have picked this to drink, but I knew that it would appeal to my friend's tastebuds.
Asking the receptionist at my hotel where to go for authentic Estonian food, she recommended this restaurant as the best choice. We had a bit of trouble navigating through the old town at night trying to find the restaurant. It didn't help that the police had the road blocked off for visiting PM Blair. With a police escort, we finally arrived!! The restaurant had a county-Scandinavian feel to it and our waitress was very friendly. The menu was available in many laguages, including English, and had a great varitey of dishes to choose from (see web page for full menu & prices). We were able to purchase a couple of the "A Le Coq" beer glasses as souveneirs for 60 EEK each. I will most likely return to this restaurant should I find myslef in Tallinn again!
Favorite Dish Started with the Beetroot Soup and Piirissaare Onions Baked in Beer Dough. The soup came in a generously-sized bowl and tastes like your typical red borshe. The onions came with a creamy green onion dipping sauce. The portion was enough for 2-3 people to share.
For dinner, I ordered the Grilled-Beef Sirloin w/ potatoes. This was a thin slice of sirloin draped over potato wedges and covered in a dark sauce - I would guess beef base with rosemary flavor. The beef was well-done, but still tender. The sauce was quite flavorful. I fifnished with the apple bomb, which was a cored & peeled apple filled with nuts and covered in a sweet sauce.
Favorite Dish I chose the 'Red Fish with Mash potatoes & boiled carrotts'. My friend chose 'Sauna cooked chicken drumsticks'.