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Search results
Rescue team issues timely warning to hillwalkers as clocks go back
Rescuers have issued a timely reminder to walkers heading for the hills to pack a torch, as the end of British summer time approaches.
BT backs down on plans to remove Seathwaite phone box after rescuers' campaign
Plans to remove a remote Lake District phone box have been dropped after a campaign by mountain rescuers who said it was vital to hillgoers' safety.
Llanberis mountain rescuers: 'we can't sustain present level of callouts'
The UK's busiest volunteer mountain rescue team said it cannot sustain the present level of callouts, following a record number during August.
Mend Our Mountains-funded work begins with Exmoor footpath restoration
Footpath repairs supported by a crowdfunding project have begun on Exmoor. A section of a route near Chains Combe in Exmoor national park is the fi...
Rescuers say precarious Lord's Rake boulder on Scafell has now split
A mountain rescue team has reported a large, precariously perched boulder on England's second highest mountain has split is now in pieces.
Mountain film-maker Terry Abraham prepares to start shooting Alan Hinkes biopic
A film-maker who chronicled two Lake District mountains is turning his lens on a mountaineer for his next project.
Wasdale pub landlord Mark Corr plans to serve his ale on Scafell Pike summit
England's highest mountain will be transformed into a temporary hostelry at the weekend. Pub landlord Mark Corr will lug a barrel containing 36 p...
Extra time for Mend our Mountains scheme as appeal extended by a week
A crowdfunding appeal to help repair mountain footpaths has gone into extra time. The British Mountaineering Council's Mend our Mountains campaig...
'Fortunate' walker, 62, survives cold night on Scafell Pike range
A walker was described by rescuers as 'very fortunate' after surviving a cold night on England's highest mountain range.
Shooting of Terry Abraham's biopic of mountaineer Alan Hinkes gets underway
Production of a biopic featuring the life of a record-breaking mountaineer is underway. Outdoors specialist Terry Abraham has begun filming his lat...
Keswick mountain rescuers plead for walkers to oppose Seathwaite phone removal
A mountain rescue team is urging outdoor enthusiasts to oppose the removal of a phone box in a remote Lake District hamlet.
Wasdale team's seven 'avoidable' callouts in 12 hours as rain lashes fells
Rescuers have again emphasised the need for hillgoers to be prepared after a team received seven callouts to England's highest mountain in 12 hours.
Rescuers urge hillgoers to go prepared as Lakeland teams deal with 'avoidable' callouts
Mountain rescuers in the Lake District are appealing to hillgoers to make the right preparations for their trip on to the fells.
Two Lake District walkers rescued in separate incidents after succumbing to heat
Two walkers were rescued from Lake District fells after getting into difficulties in the extremely hot weather.
Mountain Leader: 'I felt like Pied Piper' as numerous walkers get lost on Scafell Pike
A Mountain Leader said he felt like the Pied Piper as lost walkers tagged on to his guided group in the dark on England's highest mountain.
Review: Life of a Mountain: Blencathra by Terry Abraham
Independent film-maker Terry Abraham's second movie in a Lake District trilogy is a visually stunning portrait of 'the people's mountain'.
Time is running out to pledge cash to Mend Our Mountains crowdfunder
Time is running out for outdoor fans to pledge their cash to help a crowdfunding effort to repair some of England and Wales's most popular mountain paths.
Outdoor fans urged to help BMC's Mend Our Mountains crowdfunding path scheme
Outdoor enthusiasts are being invited to help crowdfund repairs to some of England and Wales's most used upland paths.


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Release Date: January 1st, 2012
Not Yet Rated|1 hr. 46 min.
Plot Summary
A man and his wife work on their relationship while he is imprisoned for drug smuggling.
Cast: Shirley Henderson, John Simm, Laurence Richardson, Andy Callaghan, Wilson Deuxrod, Johnny Lynch, Stephanie Kirk, Darren Tighe
Director: Michael Winterbottom
Genres: Drama

subset: commoncrawl


text:
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Today, my boyfriend and I were having Christmas dinner while his mom was away. I was lying alone on his bed while he did the dishes, when the bedroom door dramatically swung open and his mom glared at me from the doorway. I had to leave when she screamed "FORNICATION IS A SIN!" FML
by un_christmas / 12/25/2012 at 1:41am / Malaysia (Kuala Lumpur) / Love
Today, my 14-year-old daughter came home after sneaking out and partying. She was totally drunk, and started crying on my shoulder because some boy named "Thomas" has a small dick, and she had to fake an orgasm. FML
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Exploring options for a possible 2017 Festival
The VTSS team hope that Victoria's scenic Inner Harbour will provide the backdrop to a summer 2017 event – one that would touch the hearts and minds of thousands of visitors.
This very popular international event could mean, again, that Victoria will have an unprecedented opportunity to experience history first hand. Visitors will be able to walk the ships' decks, touch the massive timbers, look up through the rigging at the sky, watch a cannon battle at sea, and turn the clock back to a time when our city's future was being built by ships like these.
As we work towards a possible summer 2017 event, we need to keep in mind what is achievable and affordable. Those with ideas – please approach. – email@example.com


text:
We've made an official video, complete with live footage, for the song Deluge off the Vultures EP! Go to our music page to check it out!
"IRATA from Greensboro, NC...not only know the right way to rock; they are fully unconcerned with the trends of today. (They) make raw, unrelenting rock music that grooves when it's supposed to, crushes when it needs to and will leave you wanting more." - Keith Chachkes of Metal Distro
Previous events
Bitter Resolve / Bedowyn / Irata
The triangle's absolute best! Come party for FREE!!!!!!
Cave of Swimmers / Irata / Plow
Miami's Cave of Swimmers bring a rich tapestry of sounds and textures.
Plow are a three-piece rock instrumental from Boone, NC.
West Coast Tour 2016
3242 E. Colfax Ave. , Denver, CO 80206
Smolder and Burn TBA
West Coast Tour 2016
First Order of the Eagle, 37 1st St. W., Kalispell, MT 59901
Doors at 6 pm! $5 cover 21+
West Coast Tour 2016
Show at 10 pm FREE SHOW! 21+
West Coast Tour 2016
Samara Black Bone Exorcism
https://www.facebook.com/samaraheavy/ https://www.facebook.com/blackboneexorcism/
West Coast Tour 2016
The Know, 2026 NE Alberta St. , Portland, OR 97211
Mammoth Salmon Skulldozer
https://mammothsalmon.bandcamp.com/ https://skulldozer.bandcamp.com/
Doors at 8 21+ Tickets at Door!
West Coast Tour 2016
Chromaphonic Music Hall, 811 S. Oregon St., Yreka, CA 96097
West Coast Tour 2016
Lords of Beacon House Slig
https://lordsofbeaconhouse.bandcamp.com/releases https://slig.bandcamp.com/
West Coast Tour 2016
Nebula Drag Beira
https://nebuladrag.bandcamp.com/releases https://beiramusic.bandcamp.com/
West Coast Tour 2016
Tempe Tavern, 1810 E. Apache Blvd., Tempe, AZ 85281
Pocket Leaf Nulling Roots
https://pocketleaf.bandcamp.com/releases https://nullingroots.bandcamp.com/
West Coast Tour 2016
PINKISH BLACK - One of the most interesting and far-thinking experimental duos currently active, this group displays an unflinching capacity to dip their toes in all sorts of disparate musical markets, from doom metal and industrial to post-punk and new-wave. https://pinkishblack.bandcamp.com/
IRATA - Stopping in Fort Worth on their Summer tour, Irata not only know the right way to rock; they are fully unconcerned with the trends of today. They make raw, unrelenting rock music that grooves when it's supposed to, crushes when it needs to and will leave you wanting more. https://retrofuturist.bandcamp.com/album/irata-loris
ORCANAUT - Heavy/Ambient/Rowdy/Progressive shit from Denton TX, tumbling throughout this universe and the next. https://theorcanaut.bandcamp.com/
West Coast Tour 2016
The Lost Well, 2421 Webberville Rd. , Austin, TX 78702
Speedeater Destroyer of Light Mala Suerte
https://destroyeroflight.bandcamp.com/ https://malasuertedoom.bandcamp.com/
West Coast Tour
RATA - Stopping in Billings on their west coast tour, Irata not only know the right way to rock; they make raw unrelenting rock music that grooves when it's supposed to, crushes when it needs to and will leave you wanting more. Local support Pi+Fire; The Water Proxy
West Coast Tour 2016
Caledonia Lounge, 256 W. Clayton St., Athens, GA 30601
Volt Marses
Doors at 9; show at 10 $5 21+ $7 18-20
Irata / Beard of Antlers / Children of the Reptile / Hollow Leg
Reggie's 42nd Street Tavern, 1415 S. 42nd Street, Wilmington, NC
$5 Doors at 7
Akris / Floodlore / King Buffalo / Irata / Hollow Leg
Guido's, 543 N. Market St., Frederick, MD 21701
Free show! 21+ 9pm
Black Pussy / Borracho / Irata / Memphis Hill
The Tree House Lounge, 1006 Florida Ave. NE, Washington, DC 20002
21+ $10 Doors open 7:00 pm
Irata / Hollow Leg / Horseskull / Alpha Cop
The Maywood, 658 Maywood Ave., Raleigh, NC 27603
Hollow Leg/Irata/Spore Lord/Canopy
The Basement, 1245 Glenwood Ave. SE, Atlanta, GA 30316
You are visitor number: 1381


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Ajinkya Rahane (28 off 28) stitched 65 runs for the second wicket with captain Rahul Dravid. (BCCI)
Stuart Binny scored 40 off just 20 balls and shared an impressive 55-run partnership with Dravid. Binny struck two fours and three sixes in his knock. (BCCI)
Sri Lankan opener Kusal Perera scored just 14 off 12 balls before being dismissed by Umesh Yadav. (BCCI)
Skipper Rahul Dravid struck a magnificent half-century as Rajasthan Royals finished with 165 for 7 against Delhi Daredevils at Feroz Shah Kotla. (BCCI)
Umesh Yadav celebrates after removing Kusal Perera for 14. Delhi Daredevils' pacer claimed 4 for 24 in his spell. (BCCI)
Delhi Daredevils skipper Mahela Jayawardene scored just 19 off 16 deliveries. (BCCI)
Kevon Cooper bowled a brilliant final over to guide Rajasthan Royals to a thrilling five-run victory over Delhi Daredevils. (BCCI)
David Warner's 77 off 56 went in vain as Delhi Daredevils lost their second match in a row. (BCCI)
S Sreesanth gestures after dismissing Unmukt Chand for 23 runs. (BCCI)


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A gold crown presented to Queen Victoria in 1862 has long been described as a unique survivor and symbol of power from the Inca civilization. But new research reveals that the object's origins may be even more intriguing than previously thought.
Deborah Clarke of the Royal Collection began researching the crown's history in preparation for the exhibition Treasures from The Queen's Palaces, which opens on 16 March at The Queen's Gallery, Palace of Holyroodhouse. As part of her investigations, she asked experts at the British Museum to look at this extraordinary object. During testing and examination, it was established that the crown, excavated in Chordeleg in the South of Ecuador in 1854 and later presented to Queen Victoria by the president of Ecuador, may not in fact have been made by the Incas at all.
Dr McEwan explained that the crown 'was clearly used by a person of high status as an emblem of lordly or royal authority forming part of a suite of golden regalia, along with bracelets and anklets'. Stylistic details suggest that the crown belongs to a pre-Inca Northern Andean gold-working tradition, which encompassed the coast and northern highlands of Peru and the southern highlands of Ecuador. Dr McEwan said, 'One hypothesis therefore is that the crown could have been worn by a Cañari lord well before the Inca invasion in the 15th century.'
Book tickets to see Treasures from The Queen's Palaces at The Queen's Gallery, Palace of Holyroodhouse.


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14 Toilet Paper Roll Craft Ideas
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Lacy Eyelet Pom Poms
By: Anneliese for Aesthetic Nest
We are adding the craft to your Craft Projects.
The project was added to your Craft Projects.
Click here to view your Craft Projects.
These beautiful Lacy Eyelet Pom Poms are perfect for a summer party or wedding. Making tissue paper flowers and decorations is easy and fun, and great way to decorate on the cheap!
- A stack of 8 sheets of tissue paper
- A pair of sharp scissors
- A standard hole punch
- A long twist tie for securing
- Start by aligning the edges of your stack of tissue paper as best you can, but it doesn't matter if it isn't perfect. Then make a 1" fold down one long edge of the stack. I hold the stack and fold up from the bottom away from myself.
- Flip the whole stack over and fold up one inch again. It will look like this:
- Continue making 1" accordion style folds in this manner until the entire stack is folded. If the last fold is a bit shy of 1" that is just fine.
- Now take a pair of scissors and trim the edges so they are rounded.
- Unfold, and using your hole punch, punch little holes out of the stack of tissue around the perimeter of the scalloped edges. I punched one hole at the top center of each curve and then one on each side equal distances apart. Then I punched one in the crease.
- Then add one other hole in the center of each scallop--I aligned mine with the punched holes in the creases. You could of course do this in any order you prefer! (I love the resulting stack of punched tissue circles. You could use this for confetti!)
- Now refold the tissue along the 1" fold lines and secure in the middle with a twist tie.
- Turn the stack on its side, fan out the folds on one side and carefully separate the tissue layers. Work on one side of the pom pulling apart all the layers (gently so they don't tear) until they are spread in a 180-degree shape, then work on the other side of the pom until you have a beautiful spherical shape.
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Melody Of Oblivion Toune Requiem
A selection of articles related to melody of oblivion toune requiem.
Original articles from our library related to the Melody Of Oblivion Toune Requiem. See Table of Contents for further available material (downloadable resources) on Melody Of Oblivion Toune Requiem.
- Isis/Aset
- ISIS and ASET are really two different deities. When the worship of Isis rose, Aset had already been forgotten for hundreds of years, at this time only a small group of priests still knew how to read the hieroglyphs of the temple walls. Isis was more a Roman...
Deities & Heros >> Egyptian
- King James Bible: Ephesians, Chapter 5
- Chapter 5 5:1 Be ye therefore followers of God, as dear children; 5:2 And walk in love, as Christ also hath loved us, and hath given himself for us an offering and a sacrifice to God for a sweetsmelling savour. 5:3 But fornication, and all uncleanness, or...
New Testament >> Ephesians
- The Lovers
- They come two in one One melting of two lights Dark to light to one Moon to Sun, Mother-to-Father They come full force as one They come fire to water World unspoken to a shouting force Tornado manifesting the unseen Face of wax melting to steel Iron fist...
Poetry >> Tarot
- The Story of Brân the Blessed
- Brân was a Welsh god of the underworld whose eminence is most often associated with his the "Wonderful Head." Though he could present himself as a principal of battle, Brân was also a patron on bards, minstrels, and musicians. He was huge, colossal....
Deities & Heros >> Celtic, Welsh, Irish & Brittish
- Crow Lore
- Crow Lore One Crow Sorrow Two Crows Joy Three Crows a Wedding Four Crows a Boy Five crows Silver Six Crows Gold Seven Crows a Secret Never to be told. poem contributed by firstname.lastname@example.com Crows have in many cultures, been a bird used in divination,...
Symbology >> Animals
Melody Of Oblivion Toune Requiem is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Melody Of Oblivion Toune Requiem books and related discussion.
Suggested Pdf Resources
- 120429 program notes - Carson City Symphony
- His tone poems (descriptive symphonies), including Till ... melodies of Polovtsian Dance #17, spent time at the top of the pop music charts of the time. A chemist by profession, ...
- ccsymphony.com
- Program - Viva la Musica!
- The five movements of Requiem for the Living, however, form a narrative just as much for ... In it, the grief of the Requiem and Kyrie prayers is .... tone clusters for the organ pedals.
- www.vivalamusica.org
- to download the Resource Guide - North State Symphony
- Jan 20, 2016 Variations on a Shaker Melody, Aaron Copland. 8 ... Prairie Tune, Albert Wang ...
- northstatesymphony.org
- Music You Know & Schumann Cello Concerto - St. Louis Symphony
- Nov 21, 2014 ful and highly poetic melody that forms the prin- cipal subject of .... a great extent, the general tone of the cycle: "The firmament is blue eternally, and the ... beauty, and oblivion.
- www.stlsymphony.org
- Here - Southwest Chamber Music
- quartet: "This music attempts to be a conscience in a time of oblivion. She dared, in 'An Eye for an ... is a fragmented, stilted tune, sort of a wild jazz riff.
- www.swmusic.org
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- Making Milton Babbitt's Legacy Less Fearsome
- Sometime in the mid-1920s, a 10-year-old clarinetist in the Jackson Boys' Band in Mississippi had a small epiphany. The highest notes of his solo in an opera overture were, in fact, a transposition of the opening motif of the piece.
- A history of classical music in 50 short pieces
- From Stravinsky, who once wrote dance music for elephants, to the soap-fearing French eccentric Erik Satie, Ivan Hewett tackles the lives and works of the world's greatest composers. Listen to all 50 pieces as a Spotify playlist.
- Mozart's Final Year
- It helps, of course, if a 35‑year‑old dies, apparently in abject poverty, while writing a Requiem Mass commissioned by a mysterious stranger, clad in grey or black, according to taste. ...
- Emmanuel turns single guitar into full rock 'n'
- Want to know how guitar wizard Tommy Emmanuel handles his 300 concerts a year? He travels light! A sound engineer and a marketing person make up guitar wizard Tommy Emmanuel's entourage, along with his equipment of three acoustic guitars.
- Shibani Kashyap: A fresh take on Bollywood sounds
- Her singing career began in 1996 when she sang the signature tune for AIR FM, a channel of All India Radio, and several advertisement jingles. ...
Suggested Web Resources
- Melody of Oblivion - Wikipedia, the free encyclopedia
- The Melody of Oblivion is a series rife with cultural references ranging from Zen archery .... Toune Requiem (遠音・レクイエム, Tōne Rekuiemu): Voiced by: Sanae ... In her conversation with Bocca, Toune disclose her hatred for Melos Warriors, ...
- en.wikipedia.org
- Boukyaku no Senritsu (The Melody of Oblivion) - MyAnimeList.net
- Looking for information on Boukyaku no Senritsu (The Melody of Oblivion)? Find out more with MyAnimeList, the world's most active ... Requiem, Toune.
- myanimelist.net
- Animefringe: August 2005 - Reviews - The Melody of Oblivion Vol. 1
- As the story continues, the high school drama tone of The Melody of Oblivion ... Requiem from the Darkness is a show that truly pulls off an alternative tone that ...
- www.animefringe.com
- The Melody of Oblivion (TV) - Anime News Network
- Warriors are the only ones who can see and hear the Melody of Oblivion, a phantom girl hidden away waiting to be rescued and be the savior ..... Tone Requiem.
- www.animenewsnetwork.com
- Melody of Oblivion [HD 2015 ] - YouTube
- Feb 5, 2015 Melody of Oblivion is a manga written and drawn by Shinji Katakura. There were pre-published in the magazine Shōnen Ace of Kadokawa ...
- www.youtube.com
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Melody Of Oblivion Toune Requiem Topics
© 2000 - 2016 Realmagick.com, All Rights Reserved.


text: I have still not been able to find a load, or good starting point for these bullets. One of my co-workers, we are both Navy, came back from Iraq this weekend and he wants to go shooting so I want to get these loaded for him to play with ASAP. I have the following components. W748 BL-C(2) Varget CCI small rifle magnum primers..they worked really well with the W748 for me, I assume they will do the same for the BL-C(2) since they are both ball powders. Several different headstamp cases. I would prefer to use one of the first two powders because those are the ones I have primers for. If anyone has a load, or a good starting point PLEASE let me know. OAL would be greatly appreciated as well. Thank you.


text: I've generally told them to go outside. Our room is carpeted, so if they throw up inside, we have literally have no classroom for the rest of the day. Well, today, a kid had to throw up and headed outside, but only made it as far as the entrance to the door. He threw up all over the door, just outside the door, and all over the backpacks (room is too small for the kids to have them inside). Needless to say, this caused some major problems. Door open - vomit. Door closed - vomit. I couldn't even remove the kids from the room because they would have to step through vomit to get outside. Luckily the janitor was speedy with the cleanup. But at least my kids were positive about it. As one student remarked "Wow, that kid's really good at barfing!"


text:
People in the Department: Academics
- Academics
- Support staff
- Research staff
- PhD students
- Active retired staff
- Visiting Academics
- Visiting PhD students
This section has information on the staff within the Department, their research interests, teaching and contact details.
The Department's staff publish regularly in hundreds of separate publications, and attract research funding from a wide variety of sources, including the ERSC, NERC, Anglo-German Foundation, Department of Trade and Industry, Department of Work and Pensions, Leverhulme Foundation, and the European Commission. Staff are involved in editing some of the frontline journals in the discipline (including Progress in Physical Geography, Bulletin of Latin American Research, Journal of Economic Geography, Regional Studies, Environment and Planning C: Government and Policy, International Journal of Conservation, International Journal of Urban and Regional Research, Economic History Review). There are currently around 100 PhD students, and 50 students on Masters programmes.
Prof Bill Adams
Moran Professor of Conservation and Development and Fellow of Downing College.
Dr Harriet Allen
University Senior Lecturer and Fellow of Girton College.
Prof Ash Amin
Head of Department, 1931 Professor of Geography and Fellow of Christ's College.
Dr Neil Arnold
University Senior Lecturer and Fellow of St John's College, with duties at the Scott Polar Research Institute.
Dr David Beckingham
College Lecturer, Sidney Sussex College.
Dr Mike Bithell
Assistant Director of Research in Computing.
Dr Michael Bravo
University Senior Lecturer in Geography, with duties at the Scott Polar Research Institute, and Fellow of Downing College.
Dr Poul Christoffersen
University Senior Lecturer in Physical Geography and Fellow of Murray Edwards College.
Dr Nick Cutler
SPRI Associate; Fellow in Geography (Churchill).
Prof Julian Dowdeswell
Professor of Physical Geography, Director of the Scott Polar Research Institute and Fellow of Jesus College.
Dr Alice Evans
University Lecturer.
Dr Andrew Friend
Reader in Earth Systems Science and Fellow of Clare College.
Prof Matthew Gandy
Professor of Cultural and Historical Geography and Fellow of King's College.
Prof Philip Gibbard
Professor of Quaternary Palaeoenvironments and Member of Darwin College.
Dr Mia Gray
University Senior Lecturer and Fellow of Girton College.
Dr Michael Herzog
University Lecturer.
Dr Jessica Hope
University Lecturer.
Dr Philip Howell
University Senior Lecturer and Fellow of Emmanuel College.
Dr Alex Jeffrey
Reader in Human Geography and Fellow of Emmanuel College.
Prof Christine Lane
Professor of Geography (1993).
Prof Nigel Leader-Williams
Director of Conservation Leadership and Fellow of Churchill College.
Dr Charlotte Lemanski
University Lecturer.
Prof Ron Martin
Professor of Economic Geography and Fellow of St. Catharine's College.
Dr Emma Mawdsley
Reader and Fellow of Newnham College.
Dr Iris Möller
University Lecturer and Fellow of Fitzwilliam College.
Dr Francesca Moore
College Lecturer in Geography at Homerton College.
Dr David Nally
University Senior Lecturer in Human Geography.
Prof Clive Oppenheimer
Professor of Volcanology.
Prof Sarah Radcliffe
Professor of Latin American Geography and Fellow of Christ's College.
Dr Gareth Rees
University Senior Lecturer with duties at the Scott Polar Research Institute and Fellow of Christ's College.
Dr Alice Reid
University Lecturer, working with CAMPOP, and Director of Studies, Churchill College.
Dr Chris Sandbrook
Affiliated Lecturer and Fellow of Darwin College.
Dr Ivan Scales
College Lecturer in Human Geography at St Catharine's College.
Prof Susan Smith
Honorary Professor of Social and Economic Geography.
Prof Tom Spencer
Professor of Coastal Dynamics and Fellow of Magdalene College; Director of Cambridge Coastal Research Unit.
Dr Bhaskar Vira
Reader and Fellow of Fitzwilliam College.
Dr Liz Watson
University Senior Lecturer and Fellow of Newnham College.
Dr Ian Willis
University Senior Lecturer and Fellow of St. Catharine's College.


text:
Listen to free music played by coniglio
Blip.fm is internet radio made social. It's easy to search for, play, and discover free music recommended by real people. Join today to create your own free station and start listening to @coniglio.
coniglio good night
Mar 27, 2011 at 3:09 pm via YouTube | AMAZON | ITUNES
The Rolling Stones – Love In Vain '69| play
Mar 27, 2011 at 8:40 am via YouTube | AMAZON | ITUNES
Mar 23, 2011 at 11:32 am via YouTube | AMAZON | ITUNES


text:
My First Baby Shower Cake - Theme color were primary colors - Red, Blue and Yellow...Butter Rum Flavored Bundt Cake, with Vanilla Buttercream frosting and Fondant Bows and curliques. M & M baking pieces were also used for additional accent decor.
CakeCentral.com is the world's largest cake community for cake decorating professionals and enthusiasts.
(if this is a private computer)
Yes please, register now!


text:
Jake & Noah in Coconut Cove 3D - DominicFord
Models: Jake Steele and Noah Springs
Studio: Dominic Ford
This is the final episode in Dominic Ford's "Coconut Cove" series. In this series, 8 hot guys have sex while they were all staying at the Coconut Cove resort in Fort Lauderdale. In this scene, Jake Steele finds newcomer Noah Springs while swimming in the pool. He plays around with Noah, pushing him the pool and having sex with him both in the pool and back at his room. All the guests at the resort got quite an eyeful, as they watched the whole thing unfold.


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7 posts tagged with SF by kliuless.
Displaying 1 through 7 of 7.
The Gilded Age, Henry George, the Land Value Tax and the Progressive Era
Kim-Mai Cutler: Nothing Like This Has Ever Happened Before - "San Francisco Bay Area poverty rates in all nine counties have increased in the last economic cycle, even with the Facebook and Twitter IPOs and private tech boom. The main transfer mechanism is land and housing costs, as rising rents and evictions push service and other low-wage workers to the brink. [Henry] George's solution was a single land tax that would replace all other government revenue sources. If an owner wanted to develop their property to make it more useful or productive, George argued that they should have the right to keep the value from those efforts. But increases in the value of underlying land were created by — and ultimately belonged to — the public at large." (previously: 1,2,3) [more inside]
Equality by Edward Bellamy
Equality [internet archive] was first published in 1897: "The story takes up immediately after the events of Looking Backward with the main characters from the first novel, Julian West, Doctor Leete, and his daughter Edith. West tells his nightmare of return to the 19th century to Edith, who is sympathetic. West's citizenship in the new America is recognized, and he goes to the bank to obtain his own account, or 'credit card', from which he can draw his equal share of the national product... " (previously 1,2) [more inside]
Miles Kimball: Secular Humanism and Universalist Unitarianism
Teleotheism and the Purpose of Life - "Please give this sermon a try. I think it has much in it that will be of interest to a wide range of readers: philosophy, cosmology, evolutionary theory, and science fiction, as well as theology. And nothing in it depends on believing in God at all." Abstract: As an enlightened form of atheism, I turn to teleotheism. Teleotheism is the view that God comes at the end, not at the beginning, where I am defining "God" as "the greatest of all things that can come true." In this view, the quest to discover what are the greatest things that are possible is of the utmost importance. The best of our religious heritage is just such an effort to discover the greatest things that are possible. (via; previously)
The free development of each is the condition of the war against all
Some Paths to the True Knowledge[*] - "Attention conservation notice: A 5000+ word attempt to provide real ancestors and support for an imaginary ideology I don't actually accept, drawing on fields in which I am in no way an expert. Contains long quotations from even-longer-dead writers, reckless extrapolation from arcane scientific theories, and an unwarranted tone of patiently explaining harsh, basic truths. Altogether, academic in one of the worst senses. Also, spoilers for several of MacLeod's novels, notably but not just The Cassini Division. Written for, and cross-posted to, Crooked Timber's seminar on MacLeod, where I will not be reading the comments."
Why is Everything Tilted?
John Gray on science fiction
War of the words - Science fiction was once driven by a faith in human ability to change the world. These days, the genre seeks to expose the illusions of everyday life. cf. near-future science fiction [1,2] & radical presentism [3] (via mr)
Why Novels are a Weird Technology and Constructed Realities
Chronic Citizen: Erik Davis interviews Jonathan Lethem on Phillip K. Dick. (via) [more inside]
Page: 1


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Most Cited Molecular Aspects of Medicine Articles
The most cited articles published since 2011, extracted from Scopus.
Human serum albumin: From bench to bedsideGabriella Fanali | Alessandra Di Masi | Viviana Trezza | Maria Marino | Mauro Fasano | Paolo Ascenzi
Volume 33, Issue 3, June 2012, Pages 209-290
Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric multi-domain macromolecule, representing the main determinant of plasma oncotic pressure and the main modulator of fluid distribution between body compartments. HSA displays an extraordinary ligand binding capacity, providing a depot and carrier for many endogenous and exogenous compounds. Indeed, HSA represents the main carrier for fatty acids, affects pharmacokinetics of many drugs, provides the metabolic modification of some ligands, renders potential toxins harmless, accounts for most of the anti-oxidant capacity of human plasma, and displays (pseudo-)enzymatic properties. HSA is a valuable biomarker of many diseases, including cancer, rheumatoid arthritis, ischemia, post-menopausal obesity, severe acute graft-versus-host disease, and diseases that need monitoring of the glycemic control. Moreover, HSA is widely used clinically to treat several diseases, including hypovolemia, shock, burns, surgical blood loss, trauma, hemorrhage, cardiopulmonary bypass, acute respiratory distress syndrome, hemodialysis, acute liver failure, chronic liver disease, nutrition support, resuscitation, and hypoalbuminemia. Recently, biotechnological applications of HSA, including implantable biomaterials, surgical adhesives and sealants, biochromatography, ligand trapping, and fusion proteins, have been reported. Here, genetic, biochemical, biomedical, and biotechnological aspects of HSA are reviewed. © 2011 Elsevier Ltd. All rights reserved.
Caloric restrictionJohn R. Speakman | Sharon E. Mitchell
Volume 32, Issue 3, June 2011, Pages 159-221
Restricting the intake of calories has been practiced as a method for increasing both the length and quality of life for over 500 years. Experimental work confirming the success of this approach in animals has accumulated over the last 100 years. Lifelong caloric restriction (CR) may extend life by up to 50% in rodents, with progressively less impact the later in life it is started. This effect is matched by profound impacts on age related diseases including reduced risk of cancer, neurodegenerative disorders, autoimmune disease, cardiovascular disease and type II diabetes mellitus. The disposable soma theory of ageing suggests that CR evolved as a somatic protection response to enable animals to survive periods of food shortage. The shutdown of reproductive function during CR is consistent with this suggestion, but other features of the phenomenon are less consistent with this theory, and some have suggested that in rodents it may be mostly an artifact of domestication. CR induces profound effects on animals at all levels from the transcriptome to whole animal physiology and behavior. Animals under CR lose weight which is disproportionately contributed to by white adipose tissue. Generally animals on CR change their activity patterns so that they are more active prior to food delivery each day but total activity may be unchanged or reduced. Considerable debate has occurred over the effects of CR on resting metabolic rate (RMR). Total RMR declines, but as body mass and body composition also change it is unclear whether metabolism at the tissue level also declines, is unchanged or even increases. Body temperature universally decreases. Hunger is increased and does not seem to abate even with very long term restriction. Circulating adipokines are reduced reflecting the reduction in white adipose tissue (WAT) mass under restriction and there is a large reduction in circulating insulin and glucose levels. There are profound tissue level changes in metabolism with a generalized shift from carbohydrate to fat metabolism. Four pathways have been implicated in mediating the CR effect. These are the insulin like growth factor (IGF-1)/insulin signaling pathway, the sirtuin pathway, the adenosine monophosphate (AMP) activated protein kinase (AMPK) pathway and the target of rapamycin (TOR) pathway. These different pathways may interact and may all play important roles mediating different aspects of the response. Exactly how they generate the health benefits remains open for debate, however CR results in reduced oxidative stress and enhanced autophagy, both of which could be essential components of the beneficial effects. Most data about the effects of CR in mammals comes from work on rodents. There is limited work on non-human primates that shows promising effects and one randomized controlled trial in humans where physiological markers of the CR response are consistent with the responses in mice and rats. There are also populations of humans voluntarily restricting themselves. Humans on long term restriction report similar negative side effects to those observed in animals - perpetual hunger, reduced body temperature leading to a feeling of being cold, and diminished libido. Considerable effort has been directed in recent years to find drugs that mimic the CR response. Promising candidates are those that intersect with the critical signaling pathways identified above and include biguanides such as metformin that target the insulin signaling pathway, stilbenes (e.g. resveratrol) that affect sirtuin activity and drugs such as rapamycin that interact with mTOR signaling. Whether it will ever be possible to find drugs that capture the health benefits of CR without the negative side-effects remains unclear. Moreover, even if such drugs are developed how the current licensing system for drug use in western societies would cope with them may be a further obstacle to their use. © 2011 Elsevier Ltd. All rights reserved.
Oxidative stress in health and disease: The therapeutic potential of Nrf2 activationBrooks M. Hybertson | Bifeng Gao | Swapan K. Bose | Joe M. McCord
Volume 32, Issues 4-6, August 2011, Pages 234-246
For the past 40 years or so, oxidative stress has been increasingly recognized as a contributing factor in aging and in various forms of pathophysiology generally associated with aging. Our view of oxidative stress has been largely "superoxide-centric", as we focused on the pathological sources of this oxygen-derived free radical and the types of molecular havoc it can wreak, as well as on the protection provided by the antioxidant enzymes, especially the superoxide dismutases, catalases, and glutathione peroxidases. In the last decade our view of oxidative stress has broadened considerably, and it is now often seen as an imbalance that has its origins in our genes, and the ways in which gene expression is regulated. At the center of this new focus is the transcription factor called nuclear factor (erythroid-derived 2)-like 2, or Nrf2. Nrf2 is referred to as the "master regulator" of the antioxidant response, modulating the expression of hundreds of genes, including not only the familiar antioxidant enzymes, but large numbers of genes that control seemingly disparate processes such as immune and inflammatory responses, tissue remodeling and fibrosis, carcinogenesis and metastasis, and even cognitive dysfunction and addictive behavior. Thus, the dysregulation of Nrf2-regulated genes provides a logical explanation for the connections, both direct and indirect, between observable oxidative stress and perhaps 200 human diseases involving these various physiological processes, each reflecting a network involving many gene products. The evolutionary self-association of these many genes under the common control of Nrf2 suggests that the immune and inflammatory systems may present the largest demand for increased antioxidant protection, apart from constitutive oxidative stress resulting from mitochondrial oxygen consumption for metabolic purposes. Gene expression microarray data on human primary vascular endothelial cells and on the SK-N-MC human neuroblastoma-derived cell line have been obtained in response to the dietary supplement Protandim, a potent composition of highly synergistic phytochemical Nrf2 activators. Pathway analysis of results shows significant modulation by Protandim of pathways involving not only antioxidant enzymes, but of those related to colon cancer, cardiovascular disease, and Alzheimer disease. © 2011 Elsevier Ltd. All rights reserved.
Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complexImran Bhutto | Gerard Lutty
Volume 33, Issue 4, August 2012, Pages 295-317
There is a mutualistic symbiotic relationship between the components of the photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris (CC) complex that is lost in AMD. Which component in the photoreceptor/RPE/BrMb/CC complex is affected first appears to depend on the type of AMD. In atrophic AMD (∼85-90% of cases), it appears that large confluent drusen formation and hyperpigmentation (presumably dysfunction in RPE) are the initial insult and the resorption of these drusen and loss of RPE (hypopigmentation) can be predictive for progression of geographic atrophy (GA). The death and dysfunction of photoreceptors and CC appear to be secondary events to loss in RPE. In neovascular AMD (∼10-15% of cases), the loss of choroidal vasculature may be the initial insult to the complex. Loss of CC with an intact RPE monolayer in wet AMD has been observed. This may be due to reduction in blood supply because of large vessel stenosis. Furthermore, the environment of the CC, basement membrane and intercapillary septa, is a proinflammatory milieu with accumulation of complement components as well as proinflammatory molecules like CRP during AMD. In this toxic milieu, CC die or become dysfunction making adjacent RPE hypoxic. These hypoxic cells then produce angiogenic substances like VEGF that stimulate growth of new vessels from CC, resulting in choroidal neovascularization (CNV). The loss of CC might also be a stimulus for drusen formation since the disposal system for retinal debris and exocytosed material from RPE would be limited. Ultimately, the photoreceptors die of lack of nutrients, leakage of serum components from the neovascularization, and scar formation. Therefore, the mutualistic symbiotic relationship within the photoreceptor/RPE/BrMb/CC complex is lost in both forms of AMD. Loss of this functionally integrated relationship results in death and dysfunction of all of the components in the complex. © 2012 Elsevier Ltd. All rights reserved.
The SLC2 (GLUT) family of membrane transportersMike Mueckler | Bernard Thorens
Volume 34, Issues 2-3, April 2013, Pages 121-138
GLUT proteins are encoded by the SLC2 genes and are members of the major facilitator superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human and they are categorized into three classes based on sequence similarity. All GLUTs appear to transport hexoses or polyols when expressed ectopically, but the primary physiological substrates for several of the GLUTs remain uncertain. GLUTs 1-5 are the most thoroughly studied and all have well established roles as glucose and/or fructose transporters in various tissues and cell types. The GLUT proteins are comprised of ∼500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 membrane-spanning domains. In this review we briefly describe the major characteristics of the 14 GLUT family members. © 2012 Elsevier Ltd. All rights reserved.
The gut microbiota, obesity and insulin resistanceJian Shen | Martin S. Obin | Liping Zhao
Volume 34, Issue 1, February 2013, Pages 39-58
The human gut is densely populated by commensal and symbiotic microbes (the "gut microbiota"), with the majority of the constituent microorganisms being bacteria. Accumulating evidence indicates that the gut microbiota plays a significant role in the development of obesity, obesity-associated inflammation and insulin resistance. In this review we discuss molecular and cell biological mechanisms by which the microbiota participate in host functions that impact the development and maintenance of the obese state, including host ingestive behavior, energy harvest, energy expenditure and fat storage. We additionally explore the diverse signaling pathways that regulate gut permeability and bacterial translocation to the host and how these are altered in the obese state to promote the systemic inflammation ("metabolic endotoxemia") that is a hallmark of obesity and its complications. Fundamental to our discussions is the concept of "crosstalk", i.e., the biochemical exchange between host and microbiota that maintains the metabolic health of the superorganism and whose dysregulation is a hallmark of the obese state. Differences in community composition, functional genes and metabolic activities of the gut microbiota appear to distinguish lean vs obese individuals, suggesting that gut 'dysbiosis' contributes to the development of obesity and/or its complications. The current challenge is to determine the relative importance of obesity-associated compositional and functional changes in the microbiota and to identify the relevant taxa and functional gene modules that promote leanness and metabolic health. As diet appears to play a predominant role in shaping the microbiota and promoting obesity-associated dysbiosis, parallel initiatives are required to elucidate dietary patterns and diet components (e.g., prebiotics, probiotics) that promote healthy gut microbiota. How the microbiota promotes human health and disease is a rich area of investigation that is likely to generate fundamental discoveries in energy metabolism, molecular endocrinology and immunobiology and may lead to new strategies for prevention of obesity and its complications. © 2012 Elsevier Ltd. All rights reserved.
Consequences of oxidative stress in age-related macular degenerationStuart G. Jarrett | Michael E. Boulton
Volume 33, Issue 4, August 2012, Pages 399-417
The retina resides in an environment that is primed for the generation of reactive oxygen species (ROS) and resultant oxidative damage. The retina is one of the highest oxygen-consuming tissues in the human body. The highest oxygen levels are found in the choroid, but this falls dramatically across the outermost retina, creating a large gradient of oxygen towards the retina and inner segments of the photoreceptors which contain high levels of polyunsaturated fatty acids. This micro-environment together with abundant photosensitizers, visible light exposure and a high energy demand supports a highly oxidative milieu. However, oxidative damage is normally minimized by the presence of a range of antioxidant and efficient repair systems. Unfortunately, as we age oxidative damage increases, antioxidant capacity decreases and the efficiency of reparative systems become impaired. The result is retinal dysfunction and cell loss leading to visual impairment. It appears that these age-related oxidative changes are a hallmark of early age-related macular degeneration (AMD) which, in combination with hereditary susceptibility and other retinal modifiers, can progress to the pathology and visual morbidity associated with advanced AMD. This review reassesses the consequences of oxidative stress in AMD and strategies for preventing or reversing oxidative damage in retinal tissues. © 2012 Elsevier Ltd. All rights reserved.
The mitochondrial transporter family SLC25: Identification, properties and physiopathologyFerdinando Palmieri
Volume 34, Issues 2-3, April 2013, Pages 465-484
SLC25 is a large family of nuclear-encoded transporters embedded in the inner mitochondrial membrane and in a few cases other organelle membranes. The members of this superfamily are widespread in eukaryotes and involved in numerous metabolic pathways and cell functions. They can be easily recognized by their striking sequence features, i.e.; a tripartite structure, six transmembrane α-helices and a 3-fold repeated signature motifs. SLC25 members vary greatly in the nature and size of their transported substrates, modes of transport (i.e.; uniport, symport or antiport) and driving forces, although the molecular mechanism of substrate translocation may be basically the same. Based on substrate specificity, 24 subfamilies, well conserved throughout evolution, have been functionally characterized mainly by transport assays upon heterologous gene expression, purification and reconstitution into liposomes. Several other SLC25 family members remain to be characterized. In recent years mutations in the SLC25 genes have been shown to be responsible for 11 diseases, highlighting the important role of SLC25 in metabolism. © 2012 Elsevier Ltd. All rights reserved.
Therapeutic applications of PARP inhibitors: Anticancer therapy and beyondNicola J. Curtin | Csaba Szabo
Volume 34, Issue 6, December 2013, Pages 1217-1256
The aim of this article is to describe the current and potential clinical translation of pharmacological inhibitors of poly(ADP-ribose) polymerase (PARP) for the therapy of various diseases. The first section of the present review summarizes the available preclinical and clinical data with PARP inhibitors in various forms of cancer. In this context, the role of PARP in single-strand DNA break repair is relevant, leading to replication-associated lesions that cannot be repaired if homologous recombination repair (HRR) is defective, and the synthetic lethality of PARP inhibitors in HRR-defective cancer. HRR defects are classically associated with BRCA1 and 2 mutations associated with familial breast and ovarian cancer, but there may be many other causes of HRR defects. Thus, PARP inhibitors may be the drugs of choice for BRCA mutant breast and ovarian cancers, and extend beyond these tumors if appropriate biomarkers can be developed to identify HRR defects. Multiple lines of preclinical data demonstrate that PARP inhibition increases cytotoxicity and tumor growth delay in combination with temozolomide, topoisomerase inhibitors and ionizing radiation. Both single agent and combination clinical trials are underway. The final part of the first section of the present review summarizes the current status of the various PARP inhibitors that are in various stages of clinical development. The second section of the present review summarizes the role of PARP in selected non-oncologic indications. In a number of severe, acute diseases (such as stroke, neurotrauma, circulatory shock and acute myocardial infarction) the clinical translatability of PARP inhibition is supported by multiple lines of preclinical data, as well as observational data demonstrating PARP activation in human tissue samples. In these disease indications, PARP overactivation due to oxidative and nitrative stress drives cell necrosis and pro-inflammatory gene expression, which contributes to disease pathology. Accordingly, multiple lines of preclinical data indicate the efficacy of PARP inhibitors to preserve viable tissue and to down-regulate inflammatory responses. As the clinical trials with PARP inhibitors in various forms of cancer progress, it is hoped that a second line of clinical investigations, aimed at testing of PARP inhibitors for various non-oncologic indications, will be initiated, as well. © 2013 Elsevier Ltd. All rights reserved.
Leptin as an immunomodulatorClaudio Procaccini | Emilio Jirillo | Giuseppe Matarese
Volume 33, Issue 1, February 2012, Pages 35-45
Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. Initially described as an antiobesity hormone, leptin has subsequently been shown also to influence basal metabolism, hematopoiesis, thermogenesis, reproduction, and angiogenesis. As a cytokine, leptin can affect thymic homeostasis and the secretion of acute-phase reactants such as interleukin-1 (IL-1) and tumor-necrosis factor-alpha (TNF-α). Leptin links nutritional status and proinflammatory T helper 1 (Th1) immune responses and the decrease in leptin plasma concentration during food deprivation leads to impaired immune function. Similar to other pro-inflammatory cytokines, leptin promotes Th1-cell differentiation and can modulate the onset and progression of autoimmune responses in several animal models of disease. Here, we review the advances and controversy for a role of leptin in the pathophysiology of immune responses and discuss novel possible therapeutic implications for leptin modulators. © 2012 Elsevier Inc. All rights reserved.
The SLC22 family with transporters of organic cations, anions and zwitterionsHermann Koepsell
Volume 34, Issues 2-3, April 2013, Pages 413-435
The SLC22 family contains 13 functionally characterized human plasma membrane proteins each with 12 predicted α-helical transmembrane domains. The family comprises organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). The transporters operate as (1) uniporters which mediate facilitated diffusion (OCTs, OCTNs), (2) anion exchangers (OATs), and (3) Na+/zwitterion cotransporters (OCTNs). They participate in small intestinal absorption and hepatic and renal excretion of drugs, xenobiotics and endogenous compounds and perform homeostatic functions in brain and heart. Important endogeneous substrates include monoamine neurotransmitters, l-carnitine, α-ketoglutarate, cAMP, cGMP, prostaglandins, and urate. It has been shown that mutations of the SLC22 genes encoding these transporters cause specific diseases like primary systemic carnitine deficiency and idiopathic renal hypouricemia and are correlated with diseases such as Crohn's disease and gout. Drug-drug interactions at individual transporters may change pharmacokinetics and toxicities of drugs. © 2012 Elsevier Ltd. All rights reserved.
Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complicationsMi Jeong Lee | Yuanyuan Wu | Susan K. Fried
Volume 34, Issue 1, February 2013, Pages 1-11
Obesity, defined as excess fat mass, increases risks for multiple metabolic diseases, such as type 2 diabetes, cardiovascular disease and several types of cancer. Over and above fat mass per se, the pattern of fat distribution, android or truncal as compared to gynoid or peripheral, has a profound influence on systemic metabolism and hence risk for metabolic diseases. Increases in upper body adipose tissue (visceral and abdominal subcutaneous) confer an independent risk, while the quantity of gluteofemoral adipose tissue is protective. Variations in the capacity of different depots to store and release fatty acids and to produce adipokines are important determinants of fat distribution and its metabolic consequences. Depot differences in cellular composition and physiology, including innervation and blood flow, likely influence their phenotypic properties. A number of lines of evidence also support the idea that adipocytes from different anatomical depots are intrinsically different as a result of genetic or developmental events. In this chapter, we will review the phenotypic characteristics of different adipose depots and mechanisms that link their depot-specific biology to metabolic complications in men and women. © 2012 Elsevier Ltd. All rights reserved.
The SLC16 gene family-Structure, role and regulation in health and diseaseAndrew P. Halestrap
Volume 34, Issues 2-3, April 2013, Pages 337-349
The SLC16 gene family has fourteen members. Four (SLC16A1, SLC16A3, SLC16A7, and SLC16A8) encode monocarboxylate transporters (MCT1, MCT4, MCT2, and MCT3, respectively) catalysing the proton-linked transport of monocarboxylates such as l-lactate, pyruvate and ketone bodies across the plasma membrane. SLC16A2 encodes a high affinity thyroid hormone transporter (MCT8) and SLC16A10 an aromatic amino acid transporter (TAT1). The substrates and roles of the remaining eight members are unknown. All family members are predicted to have 12 transmembrane helices (TMs) with intracellular C- and N-termini and a large intracellular loop between TMs 6 and 7. This topology has been confirmed for MCT1 and a three-dimensional structure has been modelled that suggests a plausible molecular mechanism. For correct plasma membrane expression and activity MCTs1-4, but not MCT8, require association with basigin or embigin; these are glycoproteins with a single TM and 2-3 extracellular immunoglobulin domains. SLC16 family members are involved in a wide range of metabolic pathways including energy metabolism of the brain, skeletal muscle, heart and tumour cells, gluconeogenesis, T-lymphocyte activation, bowel metabolism, spermatogenesis, pancreatic β-cell malfunction, thyroid hormone metabolism, and drug transport. MCTs 1-4 have distinct properties, tissue distribution and subcellular localisation that are appropriate for these metabolic roles. Their potential as pharmacological targets has been recognised with the discovery of potent and specific MCT1 inhibitors that act as immunosuppressant drugs by preventing proliferation of T-lymphocytes. It is suggested that the development of other drugs specifically targeting different MCT isoforms may provide a novel approach to cancer chemotherapy. © 2012 Elsevier Ltd. All rights reserved.
Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevityVittorio Calabrese | Carolin Cornelius | Salvatore Cuzzocrea | Ivo Iavicoli | Enrico Rizzarelli | Edward J. Calabrese
Volume 32, Issues 4-6, August 2011, Pages 279-304
Understanding mechanisms of aging and determinants of life span will help to reduce age-related morbidity and facilitate healthy aging. Average lifespan has increased over the last centuries, as a consequence of medical and environmental factors, but maximal life span remains unchanged. Extension of maximal life span is currently possible in animal models with measures such as genetic manipulations and caloric restriction (CR). CR appears to prolong life by reducing reactive oxygen species (ROS)-mediated oxidative damage. But ROS formation, which is positively implicated in cellular stress response mechanisms, is a highly regulated process controlled by a complex network of intracellular signaling pathways. By sensing the intracellular nutrient and energy status, the functional state of mitochondria, and the concentration of ROS produced in mitochondria, the longevity network regulates life span across species by co-ordinating information flow along its convergent, divergent and multiply branched signaling pathways, including vitagenes which are genes involved in preserving cellular homeostasis during stressful conditions. Vitagenes encode for heat shock proteins (Hsp) Hsp32, Hsp70, the thioredoxin and the sirtuin protein systems. Dietary antioxidants, such as carnosine, carnitines or polyphenols, have recently been demonstrated to be neuroprotective through the activation of hormetic pathways, including vitagenes. The hormetic dose-response, challenges long-standing beliefs about the nature of the dose-response in a lowdose zone, having the potential to affect significantly the design of pre-clinical studies and clinical trials as well as strategies for optimal patient dosing in the treatment of numerous diseases. Given the broad cytoprotective properties of the heat shock response there is now strong interest in discovering and developing pharmacological agents capable of inducing stress responses. In this review we discuss the most current and up to date understanding of the possible signaling mechanisms by which caloric restriction, as well hormetic caloric restriction-mimetics compounds by activating vitagenes can enhance defensive systems involved in bioenergetic and stress resistance homeostasis with consequent impact on longevity processes. © 2011 Elsevier Ltd. All rights reserved.
Vascular endothelial growth factors and receptors: Anti-angiogenic therapy in the treatment of cancerSònia Tugues | Sina Koch | Laura Gualandi | Xiujuan Li | Lena Claesson-Welsh
Volume 32, Issue 2, April 2011, Pages 88-111
Vascular endothelial growth factors (VEGFs) are critical regulators of vascular and lymphatic function during development, in health and in disease. There are five mammalian VEGF ligands and three VEGF receptor tyrosine kinases. In addition, several VEGF co-receptors that lack intrinsic catalytic activity, but that indirectly modulate the responsiveness to VEGF contribute to the final biological effect. This review describes the molecular features of VEGFs, VEGFRs and co-receptors with focus on their role in the treatment of cancer. © 2011 Elsevier Ltd. All rights reserved.
The ABCs of membrane transporters in health and disease (SLC series): IntroductionMatthias A. Hediger | Benjamin Clémençon | Robert E. Burrier | Elspeth A. Bruford
Volume 34, Issues 2-3, April 2013, Pages 95-107
The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease. The SLC (solute carrier) gene series has grown to now include 52 families and 395 transporter genes in the human genome. A list of these genes can be found at the HUGO Gene Nomenclature Committee (HGNC) website (see www.genenames.org/genefamilies/SLC). This special issue features mini-reviews for each of these SLC families written by the experts in each field. The existing online resource for solute carriers, the Bioparadigms SLC Tables (www.bioparadigms.org), has been updated and significantly extended with additional information and cross-links to other relevant databases, and the nomenclature used in this database has been validated and approved by the HGNC. In addition, the Bioparadigms SLC Tables functionality has been improved to allow easier access by the scientific community. This introduction includes: an overview of all known SLC and "non-SLC" transporter genes; a list of transporters of water soluble vitamins; a summary of recent progress in the structure determination of transporters (including GLUT1/SLC2A1); roles of transporters in human diseases and roles in drug approval and pharmaceutical perspectives. © 2012 Elsevier Ltd. All rights reserved.
Neuroinflammation: Modulation by flavonoids and mechanisms of actionJeremy P E Spencer | Katerina Vafeiadou | Robert J. Williams | David Vauzour
Volume 33, Issue 1, February 2012, Pages 83-97
Neuroinflammatory processes are known to contribute to the cascade of events culminating in the neuronal damage that underpins neurodegenerative disorders such as Parkinson's and Alzheimer's disease. Recently, there has been much interest in the potential neuroprotective effects of flavonoids, a group of plant secondary metabolites known to have diverse biological activity in vivo. With respect to the brain, flavonoids, such as those found in cocoa, tea, berries and citrus, have been shown to be highly effective in preventing age-related cognitive decline and neurodegeneration in both animals and humans. Evidence suggests that flavonoids may express such ability through a multitude of physiological functions, including an ability to modulate the brains immune system. This review will highlight the evidence for their potential to inhibit neuroinflammation through an attenuation of microglial activation and associated cytokine release, iNOS expression, nitric oxide production and NADPH oxidase activity. We will also detail the current evidence indicting that their regulation of these immune events appear to be mediated by their actions on intracellular signaling pathways, including the nuclear factor-κB (NF-κB) cascade and mitogen-activated protein kinase (MAPK) pathway. As such, flavonoids represent important precursor molecules in the quest to develop of a new generation of drugs capable of counteracting neuroinflammation and neurodegenerative disease. © 2012 Elsevier Inc. All rights reserved.
The SLC30 family of zinc transporters-A review of current understanding of their biological and pathophysiological rolesLiping Huang | Surapun Tepaamorndech
Volume 34, Issues 2-3, April 2013, Pages 548-560
Two families of zinc (Zn2 +) transporters are involved in zinc homeostasis in the body, SLC30 (ZnT, zinc transporter) and SLC39 (ZIP, Zinc(Zn2+)-Iron(Fe2+) Permease). The two zinc transporter family members function in opposite directions to maintain cellular zinc homeostasis. ZnT proteins contribute to the cytoplasmic zinc balance by exporting zinc out to the extracellular space or by sequestrating cytoplasmic zinc into intracellular compartments when cellular zinc levels are elevated. In contrast, ZIP proteins function to increase cytoplasmic zinc concentrations when cellular zinc is depleted. Since the cloning of the first zinc transporter (ZnT1) in 1995, there have been many advances in zinc transporter research including discovery of new members of zinc transporters, identification of gene expression patterns and regulations, recognition of protein distribution patterns in tissues and cells, and understanding of their physiological and pathological roles in humans and animal models. Ten members of the ZnT family have been identified so far. Here we give a review of these advances and discuss the pathological implications and future preventive or therapeutic applications of ZnTs. © 2012 Elsevier Ltd. All rights reserved.
Immunity as a link between obesity and insulin resistanceNishan S. Kalupahana | Naima Moustaid-Moussa | Kate J. Claycombe
Volume 33, Issue 1, February 2012, Pages 26-34
Obesity is a major public health problem in the United States and worldwide. Further, obesity is causally linked to the pathogenesis of insulin resistance, metabolic syndrome and type-2 diabetes (T2D). A chronic low-grade inflammation occurring in adipose tissue is at least in part responsible for the obesity-induced insulin resistance. This adipose tissue inflammation is characterized by changes in immune cell populations giving rise to altered adipo/cytokine profiles, which in turn induces skeletal muscle and hepatic insulin resistance. Detailed molecular mechanisms of insulin resistance, adipose tissue inflammation and the implications of these findings on therapeutic strategies are discussed in this review. © 2012 Elsevier Inc. All rights reserved.
PARP-1 and gene regulation: Progress and puzzlesW. Lee Kraus | Michael O. Hottiger
Volume 34, Issue 6, December 2013, Pages 1109-1123
Poly(ADP-ribose) polymerase-1 (PARP-1), also referred to as ADP-ribosyltransferase Diphtheria toxin-like 1 (ARTD1), is an abundant nuclear protein that plays key roles in a variety of nuclear processes, including the regulation of transcription. PARP-1 possesses an intrinsic enzymatic activity that catalyzes the transfer of ADP-ribose (ADPR) units from nicotinamide adenine dinucleotide (NAD+) onto target gene regulatory proteins, thereby modulating their activities. Although great strides have been made in the past decade in deciphering the seemingly opposing and varied roles of PARP-1 in gene regulation, many puzzles remain. In this review, we discuss the current state of understanding in this area, especially how PARP-1 interfaces with various components of gene regulatory pathways (e.g., the basal transcription machinery, DNA-binding transcription factors, coregulators, chromatin remodeling, histone modifications, and DNA methylation). In addition, we discuss some gene-specific, cell type-specific, and cell state-specific effects of PARP-1 on gene regulation, which might contribute to its biological functions. Finally, we review some of the recent progress targeting PARPs using chemical inhibitors, some of which may alter PARP-1-dependent gene regulatory programs to promote therapeutic outcomes. © 2013 Elsevier Ltd. All rights reserved.
The SLC3 and SLC7 families of amino acid transportersDimitrios Fotiadis | Yoshikatsu Kanai | Manuel Palacín
Volume 34, Issues 2-3, April 2013, Pages 139-158
Amino acids are necessary for all living cells and organisms. Specialized transporters mediate the transfer of amino acids across plasma membranes. Malfunction of these proteins can affect whole-body homoeostasis giving raise to diverse human diseases. Here, we review the main features of the SLC3 and SLC7 families of amino acid transporters. The SLC7 family is divided into two subfamilies, the cationic amino acid transporters (CATs), and the L-type amino acid transporters (LATs). The latter are the light or catalytic subunits of the heteromeric amino acid transporters (HATs), which are associated by a disulfide bridge with the heavy subunits 4F2hc or rBAT. These two subunits are glycoproteins and form the SLC3 family. Most CAT subfamily members were functionally characterized and shown to function as facilitated diffusers mediating the entry and efflux of cationic amino acids. In certain cells, CATs play an important role in the delivery of l-arginine for the synthesis of nitric oxide. HATs are mostly exchangers with a broad spectrum of substrates and are crucial in renal and intestinal re-absorption and cell redox balance. Furthermore, the role of the HAT 4F2hc/LAT1 in tumor growth and the application of LAT1 inhibitors and PET tracers for reduction of tumor progression and imaging of tumors are discussed. Finally, we describe the link between specific mutations in HATs and the primary inherited aminoacidurias, cystinuria and lysinuric protein intolerance. © 2012 Elsevier Ltd. All rights reserved.
The SLC39 family of zinc transportersJeeyon Jeong | David J. Eide
Volume 34, Issues 2-3, April 2013, Pages 612-619
Zinc is a trace element nutrient that is essential for life. This mineral serves as a cofactor for enzymes that are involved in critical biochemical processes and it plays many structural roles as well. At the cellular level, zinc is tightly regulated and disruption of zinc homeostasis results in serious physiological or pathological issues. Despite the high demand for zinc in cells, free or labile zinc must be kept at very low levels. In humans, two major zinc transporter families, the SLC30 (ZnT) family and SLC39 (ZIP) family control cellular zinc homeostasis. This review will focus on the SLC39 transporters. SLC39 transporters primarily serve to pass zinc into the cytoplasm, and play critical roles in maintaining cellular zinc homeostasis. These proteins are also significant at the organismal level, and studies are revealing their link to human diseases. Therefore, we will discuss the function, structure, physiology, and pathology of SLC39 transporters. © 2012 Elsevier Ltd. All rights reserved.
Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNAZsolt Radak | Zhongfu Zhao | Sataro Goto | Erika Koltai
Volume 32, Issues 4-6, August 2011, Pages 305-315
Lipids, proteins and DNA in the central nervous system have a high sensitivity to oxidative stress. Reactive oxygen species (ROS)-induced damage increases with aging, especially in the last quarter of the life span. The so called base level of oxidative modification of lipids could be important to cell signaling, and membrane remodeling, but the ROS-mediated post translation modifications of proteins could be important to the homeostasis of protein turnover. Low levels of 8-oxo-7,8-dihydroguanine (8-oxoG) might be necessary for transcription. A high level of accumulation of lipid peroxidation, oxidative protein damage or 8-oxoG, on the other hand, accelerates the progress of aging and neurodegenerative diseases. Therefore, agents that induce the activity of repair enzymes, such as Ca(2 +)-independent phospholipase A(2) (iPLA(2)beta), methionine sulfoxide reductase, and 8-oxoguanine DNA glycosylase, or the activity of enzymes that could prevent the accumulation of oxidized, toxic proteins, such as proteasome, Lon protease, neprilysin or insulin degrading enzyme, may act as potential therapeutic tools to slow the aging process and the progress of neurodegenerative diseases. © 2011 Elsevier Ltd. All rights reserved.
Poly(ADP-ribose) signaling in cell deathLászló Virág | Agnieszka Robaszkiewicz | Jose Manuel Rodriguez-Vargas | Francisco Javier Oliver
Volume 34, Issue 6, December 2013, Pages 1153-1167
Poly(ADP-ribosyl)ation (PARylation) is a reversible protein modification carried out by the concerted actions of poly(ADP-ribose) polymerase (PARP) enzymes and poly(ADP-ribose) (PAR) decomposing enzymes such as PAR glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3). Reversible PARylation is a pleiotropic regulator of various cellular functions but uncontrolled PARP activation may also lead to cell death. The cellular demise pathway mediated by PARylation in oxidatively stressed cells has been described almost thirty years ago. However, the underlying molecular mechanisms have only begun to emerge relatively recently. PARylation has been implicated in necroptosis, autophagic cell death but its role in extrinsic and intrinsic apoptosis appears to be less predominant and depends largely on the cellular model used. Currently, three major pathways have been made responsible for PARP-mediated necroptotic cell death: (1) compromised cellular energetics mainly due to depletion of NAD, the substrate of PARPs; (2) PAR mediated translocation of apoptosis inducing factor (AIF) from mitochondria to nucleus (parthanatos) and (3) a mostly elusive crosstalk between PARylation and cell death/survival kinases and phosphatases. Here we review how these PARP-mediated necroptotic pathways are intertwined, how PARylation may contribute to extrinsic and intrinsic apoptosis and discuss recent developments on the role of PARylation in autophagy and autophagic cell death. © 2013 Elsevier Ltd. All rights reserved.
Physiological and molecular determinants of embryo implantationHaibin Wang | Shuang Zhang | Haiyan Lin | Shuangbo Kong | Shumin Wang | Hongmei Wang | D. Randall Armant
Volume 34, Issue 5, October 2013, Pages 939-980
Abstract Embryo implantation involves the intimate interaction between an implantation-competent blastocyst and a receptive uterus, which occurs in a limited time period known as the window of implantation. Emerging evidence shows that defects originating during embryo implantation induce ripple effects with adverse consequences on later gestation events, highlighting the significance of this event for pregnancy success. Although a multitude of cellular events and molecular pathways involved in embryo-uterine crosstalk during implantation have been identified through gene expression studies and genetically engineered mouse models, a comprehensive understanding of the nature of embryo implantation is still missing. This review focuses on recent progress with particular attention to physiological and molecular determinants of blastocyst activation, uterine receptivity, blastocyst attachment and uterine decidualization. A better understanding of underlying mechanisms governing embryo implantation should generate new strategies to rectify implantation failure and improve pregnancy rates in women. © 2012 Published by Elsevier Ltd. All rights reserved.


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Exogenous Growth Model Gdp Equation
A selection of articles related to exogenous growth model gdp equation.
Original articles from our library related to the Exogenous Growth Model Gdp Equation. See Table of Contents for further available material (downloadable resources) on Exogenous Growth Model Gdp Equation.
- Homoeopathy and Personal Growth
- Generally homoeopathy is believed to work thoroughly but slowly. Indeed I know many examples of constitutional treatment (meaning whole-person-healing) with homoeopathy that take months or even some years to complete. During these treatments people go through...
Body Mysteries >> Homeopathy
- Bringing it Down to Earth: A Fractal Approach
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Mystic Sciences >> Astrology
- Our Pagan Village: The Importance and Persuit of Honor
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Paganism & Wicca >> Daily Life
- The Religious Experience: A Wiccan Viewpoint
- What is religion? Religion is a set of beliefs which allow us to understand and categorize our world and our place in it. A set of beliefs which define our culture, our expectations, our views of people and behaviors we expect. I have found several different...
Religion & Philosophy >> Religions
- I am Pagan
- I am Pagan. I am a part of the whole of Nature. The Rocks, the Animals, the Plants, the Elements, and Stars are my relatives. Other humans are my sisters and brothers, whatever their races, colors, genders, sexual orientations, ages, nationalities, religions,...
Religions >> Paganism & Wicca
Exogenous Growth Model Gdp Equation is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Exogenous Growth Model Gdp Equation books and related discussion.
Suggested News Resources
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- If this decline is broadly structural then it is likely that the government will consistently miss the targeted nominal GDP growth. This has been ... For example, in 2011, actual nominal GDP was 2.
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- Jerbashian says that there are exogenous barriers to entry the study suggests that the GDP growth rate and social welfare increase with the number of telecom firm and with the toughness of competition.
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- Thus 2% of overall growth produces about 1.2% of per capita growth. That may not sound impressive.
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