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Bike Tracks
By Core Coders Ltd
Open iTunes to buy and download apps.
All day tracking for your cycle rides
Designed specifically for cyclists who want to go long and require all their cycling statistics. Press "Start" and begin recording your cycling adventures.
Easy to read statistics available in different formats, offline cycle and street maps facility and 3D Maps (iOS 9 only)
Battery efficient technology allows all day recording, no data or phone signal required for recording making Bike Tracks ideal for those long cycle rides and where data roaming charges apply. (1)
Share your cycle rides on social media or export directly to Google Earth directly on your phone.
(1) Where data roaming charges apply remember to set Data Roaming Off see iPhone User Guide for more information.
Continued use of GPS running in the background can dramatically decrease battery life.
What's New in Version 1.2.4
1. Improved speed calculation.
2. Apple Watch Integration.
3. Sharing and Export updated.
4. 3D Maps (iOS 9)
5. HealthKit connection.
6. Online Help Desk.
Customer Reviews
Almost Outstanding
Unlike many geosynchronous apps, the locator is either "Always On", or "Never." I experience unnecessary and unwanted battery drain if I forget to turn location services off when I'm done using it. I would like to see the option of location services activation "only when using the app." This wheel has been invented, and would fit nicely on this bicycle app.
Love apps
Your apps (Ski & Bike Tracks) are great and are spot on for the info a skier or biker would want. I just wish you would make one for trail running too. I've tried Strava and Under Armor's apps for trail running and they really are more for urban running. Your Bike app would do a better job at giving me the stats I want. Please make a trail running app!
Good, but not perfect
Both Ski Tracks and Bike Tracks are excellent apps when active, but both drain my battery when not in use. They would be perfect if they included location tracking "only when using the app", like all other good geosynchronous apps.
Customers Also Bought
- $1.99
- Category: Navigation
- Updated: Dec 17, 2015
- Version: 1.2.4
- Size: 19.6 MB
- Apple Watch: Yes
- Language: English
- Seller: Core Coders Ltd
- © Copyright 2011-2015 Core Coders Ltd
Compatibility: Requires iOS 7.1 or later. Compatible with iPhone, iPad 2 Wi-Fi + 3G, iPad Wi-Fi + Cellular (3rd generation), iPad Wi-Fi + Cellular (4th generation), iPad mini Wi-Fi + Cellular, iPad Air Wi-Fi + Cellular, iPad mini 2 Wi-Fi + Cellular, iPad Air 2 Wi-Fi + Cellular, iPad mini 3 Wi-Fi + Cellular, iPad mini 4 Wi-Fi + Cellular, 12.9-inch iPad Pro Wi-Fi + Cellular, and 9.7-inch iPad Pro Wi-Fi + Cellular.


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Que coincida con: click-stream X
- Ordenar por:
- Fecha ▼
- Título
- Gusta/Votos
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- Vistas
Re-imagining the Web portal
Tinniam V Ganesh Etiquetas: web user click-stream portal internet friends 2.405 vistas
Web portals had their heyday in the early 1990's. Remember Lycos, Alta-vista, Yahoo, and Excite – portals which had neatly partitioned the web into compartments for e.g. Autos, Beauty, Health, and Games etc. Enter Google. It had a webpage with a single search...
del Blog: The Tech Trek

subset: commoncrawl


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U.S. ONLY, EXCLUDING AK/HI. Store pickup is always free.
See shipping info for
details & upgrade options.
Returns are easy at any zumiez store:
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You'll be ROFL-ing and LOL-ing for days in the A-Lab Just Kitten black t-shirt.
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Paying the Price for Free SpeechKaren Lewis' worst crime, in the eyes of federal jailers, may have been talking to the Weekly.
Betty Brink
It was 2:30 a.m. when a guard woke her up and told her to pack her belongings. By 5 a.m., Karen Lucchesi Lewis was in a Bureau of Prisons bus, shackled and chained, on the way from Carswell Federal Medical Center to a holding f...
Building for the RichDAN MCGRAW
No one can accuse the Dallas Cowboys' Jerry Jones of being a bad businessman. On the contrary, he is quite a genius.
Hot WaterEastside activists join a growing line of folks worried about gas-drilling waste products.
Peter Gorman
The two neighborhood activists were worried that high-speed truck traffic and spilled sand from a gas well were creating dangerous conditions along East First Street, between the Trinity River bottoms and Oakland Boulevard.
Big Hat, More ClosetStatic
In their ongoing obsession with Dallas, Cowtonians love to play it up big any time we beat the Beast to the East. But a recent study about the number of same-sex couples in the two cities doesn't seem to have most locals ...
Real Star WarsSpace isn't the final frontier – Just the next arms race.
In the depths of the Cold War, as the arms race between the United States and Soviet Union escalated, the terrible benchmarks were recorded — nuclear test dates, the unveiling of new weapons systems, the brinksmanship of the ...
What's it Worth to Save the Fort?Cowtown's emphasis on one era has left the rest of local history in the lurch.
Jeff Prince
The three swords once belonged to a U.S. Army officer of dragoons, back in the era when swords were serious weapons of war and not just graceful things used to cut cake at weddings and to show off at fancy military drills.
Counting Craddick's WoesDAVE MCNEELY
While Gov. Rick Perry was off stumping in Iowa on behalf of Republican presidential candidate Rudy Giuliani, district-by-district political skirmishes were going on at home in Texas.
Mud LobbersUnusual in a Cowtown race, District 9 candidates get their hands dirty.
Dan McGraw
Local city council races have generally followed the "Fort Worth Way" as politicos like to call it, with candidates and their handlers playing nice and keeping to a minimum all that underhanded stuff that they do in...
Who Shot B.S.?Static
Someone tell J.R. Ewing that the Texas city he helped make famous is being knocked off the marquee for an even better soap opera. (Cue the music). It's Mansfield that surely will be topping the melodrama charts over the n...
Digging DeeperUrban-gas-well activists face an uphill battle now that real money's on the table.
Peter Gorman
When a bonus-money war broke out between major Barnett Shale players XTO Energy and Chesapeake Energy Corporation for the rights to drill for natural gas beneath three of Forth Worth's historic Southside neighborhoods, oppone...


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Nenni-0036.2 is a slight, even tiny Oraki, who has taken for herself the mantle of the cat who walks alone.
Humanity is as varied as the stars themselves.
The XKH-71 (Panther) rifle is the widely distributed rifle amongst the Liberty Guardians. Incorporating recombinant technology, the projectile can be altered depending on the tactical situation.
Habitat colonies do not occur are habitable planets, but are only found on marginal planets, asteroids, and worlds with ruined ecosystems.
A fairly average world that happens to be the headquarter site of the Earth Alliance Space Probe Agency (EASPA)
Skanda Biologicals is one of the world's premier producers of Awakened Biological Systems. Now, the party has been asked to penetrate their fortress, and destroy their research. But, can they find the force of will to do so?
When the Liberty special forces medical research and development teams needed to rebuild man, they didn't do it by halves. The result? A suite of augmentation so pervasive, that most modified operatives are more effective on their own than half of the Liberty marines put together.
PADD is an acronym for Personal Access Display Device, a hand-held computer interface. This is a science fiction "common item", found in a variety of milieus.
This is a redirecting sub
"No this is not a mispelling", the marketing suit continued, "it is a new way to express yourself, express your interests, and get your personal message…. or your corporate one across." He surveyed the room. "It is a new consumer item combining things people need with what they want."
The Future is for sale.
We can rebuild him. We have the technology. We can make him better than he was. Better…stronger…faster. - The Six Million Dollar Man
A wicked variant on an ancient weapon, the AtomForce NC-3000 is a multi-purpose, close combat tool that allows the wielder a true variety of force options at ranges too close for firearms.
The rebuilt cradle of humanity, Neo-Terra is the world created from the ashes of Old Earth.
The heart of Humanity, the Starkin Federation is the largest faction of Man amongst the stars, the mightiest vehicle of his ambition.
The Hyperprojection Drive was perhaps the most revolutionary discovery in mankind's history, enabling us to travel the stars.
The Commander of Confederation Special Operations Unit 13, the Star Falcons, Peregrine-0004.7 is an extravagant, yet highly effecient soldier. Time and time again, he has lead the Oraki black-ops teams to success, keening his unnerving war-cry.
The smallest of the Kel'Regar combat vessels, the Parasite-Fighter is an impossibly agile and quick fighter craft, though it lacks the damage output and staying power of more conventional vessels.
Kor'na'Nath is the man who has done what, in ancient times, was considered impossible. He has united the men of the Kel'Regar, to provide a skeleton by which they may survive the world outside Regar.
The high ambassador of the Kel'Regar to the Earthling federation, the unearthly Ku'ar'Riss is a terrifying creature to behold, her desires as dark and alien as her skin.
The PCs see a large oak tree, a curious species of yellow and black butterflies swarm around it. Upon further inspection they find that the tree is hollow and that there is an underground cave in it from which the butterflies appear. Will they inspect this strange cave?


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Pantene Smooth & Sleek mini shampoo for smooth hair that lasts all day.
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Baby Boom is a 1987 romantic comedy film directed by Charles Shyer, written by Nancy Meyers and Shyer, and produced by Meyers and Bruce A. Block for United Artists. It stars Diane Keaton as a yuppie who discovers that a long-lost cousin has died, leaving her a six-month-old baby girl as inheritance. Wikipedia
From this profile you will find 8 photos, 7 quotes, 1 magazine, 48 lists, 1 song, 3 awards, 8 news stories, and key facts about Baby Boom!
Baby Boom is a member of the following lists: American films, English-language films, United Artists films, Films set in New York City, Films set in Vermont, Business films, Films shot in New York City, 1980s romantic comedy films, Films shot in Los Angeles, California and Films directed by Charles Shyer.
Need more information? Read more about Baby Boom »
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Fritz Curtis: (to an executive) This is Elizabeth. J.C. is taking care of her for a while.
J.C. Wiatt: Well, Fritz, I'm actually keeping her a little longer than that.
Fritz Curtis: Oh? How long?
J.C. Wiatt: (distracted) Oh, forever!
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Skip to comments.Watch What Happens When a Democratic Rep. Decides She Doesnt Want to Answer Questions About
Posted on 12/09/2013 2:58:40 PM PST by Nachum
Rep. Ann Kuster (D-N.H.) at a town hall meeting refused to answers questions about last years deadly terror attack on the U.S. diplomatic compound in Benghazi, Libya.
The New Hampshire representative appeared to try to dodge the question by saying Benghazi isnt in the Middle East, and therefore not pertinent to the discussion at hand.
Im certainly not here to talk about it, were here to talk about the Middle East, Kuster said in response to an attendees written question.
Libya is located in north Africa. Differing definitions place it either inside or outside the Middle East.
Regardless, the crowd clearly was not satisfied with Kusters answer.
Her comment was prompted by a written letter asking for her thoughts on a bill sponsored by Rep. Frank Wolf (R-Va.) calling for Congress to form a select committee to investigate the Benghazi attacks.
(Excerpt) Read more at theblaze.com ...
I ..uh,... Benghazi...not my job... I uh...duh.. um..
-have to go to the bathroom. Be right back.
She's technically right but only used it to weasel on the question.
Next time they should use the term "Muslim world".
A man has to help the little lady out - and give a lecture on civility.
NH residents should keep this woman in mind if they need to chock a wheel, she's clearly got the IQ of a brick.
She thinks the Middle East is Fairfax county in Virginia - not too far north, not too far south.
She is just being as honest as 'Rats are wont to do...
"Ben Ghazi? Sorry, I don't know a.... Ben Ghazi, never heard of him."
All dems know they have a solemn duty to protect their Master and to continue the massive coverup about the deaths in Benghazi.
Yes I thought it strange that she was too stupid to answer for herself and had to gat an Aide to answer for her.
Does he vote in Congress for her too, or does she just vote the way he tells her to.
That is my rep, covering herself with stupidity. They are just lucky that she didn't launch into a profane tirade!
If she was curious, that would mask her ignorance.
Maybe that's why our SOCIALIST DEMOCRATIC PRESIDENT didn't do anything about it that night. HE DIDN'T KNOW WHERE IT WAS.
There are many thousands of intelligent, qualified Americans who could run for Congress. NH picks this mumbling cipher?
She defeated a Republican incumbent by 5 points last Nov.
I'd say she's bulletproof.
Nope. Ben Dover.
> refused to answers questions about last year's deadly terror attack on the U.S. diplomatic compound in Benghazi, Libya. The New Hampshire representative appeared to try to dodge the question by saying Benghazi isn't in the Middle East, and therefore not pertinent to the discussion at hand.
Thanks Nachum.
That's a MAN, man!
She would look BRILLIANT in a burqa!
He must of assumed Ben Gazi was some Jewish nobody. We could accept that.
The more coverage for her face, the better.
Would you PLEASE unlock your caps? Sheeesh, that's annoying.
What a copout, this Ann Kuster, claiming that Libya is not in the Middle East! All nations whose populations are predominantly of Arab ethnicity are in the Middle East, no ifs, ands or buts. She also has the nerve to say that the House is not involved with Benghazi, it's only a Senate thing.
Remember when the loony lefties were chanting, "Bush lied, people died"? With Benghazi, the message here is "Americans die, Democrats lie!"
This Kuster has to be targeted for defeat next November! She's a real DUMMYcrat who can't even reply to basic questions at a Town Hall meeting because she's scared that she might get in trouble with the Obama White House if she discussed Benghazi, because she might have to admit that Islamic terrorists killed Americans.
Jeepers... thanks for the ping!
Ben Gazzara bump
I'm sorry it's just funny.
All nations whose populations are predominantly of Arab ethnicity are in the Middle East, no ifs, ands or buts
Well no, technically she is correct, among the North African nations some people only include Egypt in "The Middle East". Some include Libya also. Doesn't seem like like anyone counts Tunisia, Algeria or Morocco despite them being Arab countries. They are hardly very "east".
But really, what a pathetic cop out. Pathetic woman.
The article: "She eventually became silent and stood there as the crowd became more unsatisfied with her answers. An event staffer had to come to her rescue and redirect the meeting. There are a lot of different ideas and a lot of different opinions here, he said. So, were going to stick to the format of answering questions [on the postcards] rather than get into a discussion that goes on.
You may want to take Tunisia, Morocco, and Algeria out of the Middle East, but I wouldn't. They are much more similar to Egypt, Libya, Saudi Arabia, Iraq, etc. ethnically, culturally, historically, religiously, and politically than they are to any European country or to the sub-Saharan African countries.
"Uh, I was just diagnosed with global transient
amnesia but only on the subject of Benghazi."
OBAMA HILLARY LOVE FEST ON 60 MINUTES---Obombo had
just hustled Hillary onto 60 Minutes to gaze in adoration, after her arrogant
dismissal of the Benghazi massacre before Congress.
MILITARY.COM reported that US Pentagon officials declined to give specifics on conversations between DOD's Chuck Hagel and Egyptian Gen al-Sisi....WRT the post-Morsi Egyptian crisis.
Although the officials would not discuss the specifics of the military-to-military talks, the U.S. would need Gen al-Sisi's approval to move through Egyptian air space if Washington decided to send Marines to aid in the evacuation of U.S. personnel.
READY TO ROLL About 550 Marines and their tilt-rotor MV-22 Osprey aircraft are at bases in Spain and Italy on standby if they are needed. A Navy Amphibious Ready Group with 4,000 Marines and sailors aboard, led by the helicopter assault ship Kearsarge, was also in the region following completion of the Eager Lion training exercises in Jordan.
© Copyright 2013 Military.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
AIN'T KARMA A *ITCH, HILLARY?...... the helicopter assault ship Kearsarge, WAS in the region. We were lied to----we were told it was not available to help endangered Americans in Benghazi.
(Q.) Who holds the key to unlocking the Benghazi secrets Obama and Hillary will not divulge?
(A.) That would be Egyptian Gen Al-Sisi who drove blood-thirsty Muslims out of Egyptian politics and has vowed to rebuild the 63 churches torched by the Muslim Brotherhood.
Right now, sitting in an Egyptian jail is a man al-Sisi arrested for inciting terrorism. That man is Gehad al Hadad....once employed by the tax-exempt Clinton Foundation.
THE CLINTONS IN-HOUSE MUSLIM TERRORIST the Clintons tax-exempt foundation employed a Muslim Brotherhood activist.
Gehad el-Haddad
(The stupid Clintons did not know Gehad was Farsi for "jihad")
Gehad also knows how the Muslim Brotherhood launders money to finance terrorism, using "tax-exempt foundations."
As far as I know, Egypt does not have any limitations on obtaining information from terrorists---like prohibiting waterboarding, etc.
Rest assured---we will know everything---all in good time.
The Bush admin used the term "The Greater Middle East " to to include all of North Africa and the former Soviet states with high Muslim populations, the term did not really catch on.
I don't see this as anything to argue about.
"Pathetic" = Definition of all Democrats.
Don't forget that she is where she is because she received a majority of the votes cast in her district. That means that most of the voters in her district want her to be where she is. Proving that once again, we get the Government we deserve.
You have to get used to Obvama's cpnvenient geography. You see its the old geography of the Egytian Caliphate which was distinctly different than the Caliphate of Damascus.
Obamas geograhy follows the old divisions of Islam. And now, so does Keister Kuster.
as most know, Kuster is facing a difficult re-election. FYI, Manchester in NOT in her district.
"The town hall took place on Nov. 25 in Manchester, N.H., and hosted by the Jewish Federation of New Hampshire.
Footage from the event only recently surfaced online. The National Republican Congressional Committee, which is responsible for the videos circulation, said Kusters refusal to answer is inexcusable."
Why is the dumb little witch holding town halls outside her district? Does anyone do that?
Benghazi ping.
Let Republicanprofessor know if you want on or off this ping list.
Given the America we live in today, she will win reelection easily.
That is a style of expression. I suggest that you will feel better if you are less annoyed.
Over the internet, using all caps is considered shouting, and yes, it can be annoying.
As for it being a "style of expression", I assure you it's not. Ask the poster why he posts that way. He has a reason.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


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Dan & Thierry - BulldogPit
Models: Dan Jenkins and Thierry Schaffauser
Studio: Bulldog Pit
Cute Thierry takes the lead in this hot duo as the hung fucker out to satisfy his needs with a cock hungry twink called Dan. Wanting nothing more than to be filled with pulsating shafts as they quiver rigid, Dan's mouth does the job, and soon his asshole is forced to take over. Thierry works in a finger, loosening him up, ready to take all his dick in one foul swoop. Thierry's body looks fucking amazing as his works that butthole around his dick. Solid abs, tight shoulders and of course, that dick going in and out looks horny as hell. Building up the speed and position changes give us the best views of twink fucking, hot butts rammed with big dicks, it's pure heaven.


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Buy Greg Bennett RL-3 Semi Hollow Electric Guitar Natural online in India at the best price with free shipping from BAJAAO - India's music equipment superstore.
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ISSUES AND ARTICLES MOST READ eTOC
Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111
Frequency: Monthly
Online ISSN 1827-1928
(Biochemistry, Immunology, Kinanthropometry, Neurology, Neurophysiology, Ophtalmology, Pharmacology, Phlebology, etc.)
Martarelli D. 1, Cocchioni M. 1, Scuri S. 1, Spataro A. 2, Pompei P. 1
1 Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Macerata, Italy
2 Department of Cardiology, National Institute of Sport Medicine, Rome, Italy
AIM.We determined the combined effects of cold and exercise on oxidative stress during submaximal exercise.
METHODS:Sixteen amateur male cyclists pedaled at a constant speed corresponding to 85% of maximal HR as determined in normal conditions. Eight athletes pedaled indoors at 23 °C while 8 athletes pedaled outdoors at a temperature of 4-6 °C. We then evaluated the levels of reactive oxygen metabolites and plasma levels of antioxidants after exercise.
RESULTS:Performing a physical task in cold conditions increased the free radical production, as demonstrated by the augmented levels of reactive oxygen metabolites and the concomitant decrease of plasma levels of antioxidants in outdoors cyclists as compared to indoors cyclists. The overall ANOVA and the post-hoc comparisons revealed a significant exercise and temperature effect. The mean level of reactive oxygen metabolites in athletes who exercised indoors was significantly lower than that of the outdoor athletes. Moreover, the outdoors group presented plasma levels of antioxidants significantly lower than those of the indoors group.
CONCLUSION: Since several sports are performed outdoors during the winter season, the increased risk of oxidative stress in cold conditions must be considered in these disciplines. Cyclists, football and rugby players, and runners are all affected by the elevation in oxygen radicals induced by cold and should take appropriate precautions, such as specific antioxidant integration.
language: English


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Phoenix, AZUSA
Hometown: Phoenix
July 20, 2013
Meeting other cool like-minded people
I have a talent for reactive comedy
Video games and music
Just about any activity, really. Big fan of concerts and group games (like Cards Against Humanity).
31, Single, Systems Administrator (computer stuff)
Born and raised Phoenician always looking for an excuse to get out and have some fun!
You'll find a good mix of outgoing and introverted individuals here and if you're already on Meetup that means you're ready to be a little less shy. This group is very friendly and doesn't give off a vibe of "putting on airs".
Meetup members, Log in
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15th Annual Palo Alto Weekly Photo Contest
"Temple, New Territories"
About Deborah Angel
Deborah Angel is a Palo Alto reference librarian with a passion for photography.
She snapped her winning shot near Tai Po, a market town in Hong Kong.
"My nephew invited me to visit him," she said. "I just grabbed a bag and went."
The photograph was taken of a small temple situated behind a massive, main temple. Angel was surprised the picture came out so well because she was traveling with a small 3-megapixel digital camera.
She first learned to take photographs with a Brownie box camera when she was 10. Although her favorite photography is black and white, she mostly takes color shots and transitioned to digital photography two years ago. For her next project, she plans to go to Japan to photograph teahouses and street scenes.
Angel originally hails from a very small Welsh village called Llannon. She moved to Palo Alto 18 years ago and currently works at the main library.
The 2016-17 Info Guide is here!
Info Palo Alto, a resource guide for the Midpeninsula, features local information on schools, outdoors and recreation, government and arts & entertainment


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|Joined: Feb 21, 2011
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|Forum Threads: 1
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|Rep Points: 6
Recent Community Posts
Great Customer Service.
Posted: Feb 21, 2011 by dillian | 0 comments | Bank Reviews
This bank is new to my area but I am very glad I opened an account with them. Their website is simple and easy to use, their service is fast and the read more


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2 years of experience
Accepting new patients
2 years of experience
Accepting new patients
540 Clay Mathis Rd
Mesquite, TX 75181 Phone number & directions
Mesquite, TX 75181 Phone number & directions
License & Identifications
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. Jeremy Curtis:
View the full profile to get information on:
- Qualifications
- What's important to you
View full profile
Patient Reviews
Patient comments (0)
The overall average patient rating of Dr. Jeremy Curtis is Excellent.
Education & Awards
Dr. Curtis graduated from Temple University Physicians, Philadelphia.
- Spanish
Home > Find a Dentist > TX > Mesquite Dentists > Dr. Jeremy Curtis, DDS, DMD
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- Additional Information
- Dr. Jeremy James Curtis DDS and DMD is a male dentist, has 2 years of experience and practices in Family Dentistry.
- Where does Dr. Jeremy J. Curtis practice?
- Dr. Jeremy Curtis has 1 office location.
Dr. Jeremy Curtis practices Family Dentistry near Mesquite, TX.
See Mesquite Dentists.


text:
Transcript-Savvy Discovery Is a Smart Bet
Drug Developers Are Finding Ways to Bend the Transcriptome to Their Will
Molecular Dx Has Your (Copy) Number
CNV Detection and Analysis Tools Are Being Used To Fill Genetic Diagnostic Gaps
Humanizing Animals for Immuno-Oncology
Success in Humanizing Mice Has Inspired Similar Efforts in Rats, Pigs, and Other Animals
Probiotics Help Save the Spine
Sounds of Science Podcast
Presidio Secures $27M to Advance Preclinical Assets
Presidio Pharmaceuticals closed a $27 million financing round bringing the total raised to about $53 million. The funds will be used to advance its NS5A inhibitor program in HCV through clinical studies and to support the development of other programs in the pipeline.
The firm's other preclinical candidate, PPI-802, is being investigated as a treatment of HIV. Additionally, Presidio has an HIV and an HCV program at the discovery stage.
New Leaf Venture Partners joined the current investors, Panorama Capital, Baker Brothers Investments, Ventures West Capital, Bay City Capital, Nexus Medical Partners, and Sagamore BioVentures. The last investment round of $26 million was led by Panorama Capital.
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to the sale of the company ?
Whether or not the company ends up sold, or is even in play is somewhat academic.The closed stores were primarily markets the company should not have expanded to. It was very apparent they blew it years ago, it was too bad it took so long to close them and refocus on what they do well, move geographically into areas adjacent to their saturated markets, as opposed to jumping across the country.


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"True Blood"-Trailer Staffel 6
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"True Blood"-Trailer Staffel 6
A Big Chill Is Moving Across the United States This Week
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"True Blood"-Trailer Staffel 6
"True Blood" geht endlich weiter. Sehen Sie jetzt den ersten Trailer zur neuen Staffel der erfolgreichen Vampirserie.
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A Big Chill Is Moving Across the United States This Week
Temperatures are dropping after a last week's record heat.
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US-Backed Iraqi and Kurdish Forces Continue the Fight for Mosul
More villages were liberated today as the battle wages on for the largest ISIS stronghold in Iraq.
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A Police Officer With a Civilian Ride-Along Turns Dangerous in California
Gunfire rang out after the police officer attempted to make a traffic stop.
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New Polls Show That Clinton Has a Bigger Lead as Election Day Nears
Trump is losing ground with many groups, including white men.
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Hillary Clinton Campaigns Hard in Longtime Republican Strongholds
The Democratic candidate is now trying to turn red states blue.
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A Deadly Collison in Southern California Shuts Down Interstate 10 for Hours
A casino tour bus crashes into a semi-truck with multiple injuries and deaths.
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AP Top Stories 23 P
Here's the latest for Sunday, October 23rd: At least 7 killed in a tour bus crash in California; Ash Carter visits Iraq; The presidential candidates hit the swing states and Cubs fans celebrate their 1st World Series appearance in 71 years.
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16 in 2016: Dr. Harold Bornstein
Dr. Harold Bornstein, a gastroenterologist in New York City, has been Trump's physician for 35 years. He came under public scrutiny recently when he wrote a letter describing Trump's health in glowing terms. It was later discovered that he wrote the letter in five minutes. As pressure mounted for the candidates to be more transparent about the state of their health, Dr. Bornstein released a more detailed letter on Trump, who later touted the results on "The Dr. Oz Show." See more at yahoo.com/16in2016.
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Clinton Rallies with 'Mothers of the Movement'
Hillary Clinton campaigned with a a group of mothers who have lost children to gun violence or through contact with the police, known collectively as the 'mothers of the movement." They along with Clinton urged voters to cast their ballots early. (Oct. 13)


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Beiersdorf researchers have developed a deodorant based on polyquaternium-16 that decreased the production of axillary bacteria, in turn reducing malodor. So no, there's nothing to smell here (but innovation).
This year's congress brought together more than 1,100 attendees worldwide to discuss what makes "scents" in fragrance sustainability.
Despite a volatile political and economic landscape, Symrise exhibited strong growth in segments and regions.
The U.S. National Institute of Allergy and Infectious Diseases is sponsoring the research to test nootkatone against mosquitoes carrying the Zika virus.
The days of skimping and saving to fit that amber note into your fragrance price point could be long gone. Inventors from Symrise appear to have a new answer to amber, as this patent application explains.
What's your reaction to cyclohexal? The EU's is concern, while Givaudan's is this patent application to emit lily of the valley scent without worry. I'll bet your itching to read more.
Never before has an interactive discussion between a fragrance house and its client taken place in a public setting. Never before until today, that is—when Jeb Gleason-Allured, editor in chief of Perfumer & Flavorist and Global Cosmetic Industries magazines, and program director of the World Perfumery Congress (WPC), brought both to the stage to lead attendees through the dynamics of the client-perfumer relationship and the power it brings to brands.
Attending perfumers and other fragrance professionals were invited to explore raw materials and inspired to approach creative projects in new ways.
SC Johnson now lists all ingredients for products sold in the majority of European countries, as well as the United States.
Phew—smell that? Odors are out there, lingering until heat and humidity unleash their dirty-socks-in-the-gym-bag potential. That's where pro-scent solutions like this Henkel compound come in, locked and loaded.


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Vikings coach Brad Childress said Friday that Harvin was still dealing with some effects of his migraine headaches, placing his status for Sunday's game at "questionable."
Harvin played and was effective until he left in the fourth quarter when his leg got bent back at the end of a kickoff return.
"Same spot. He tweaked it," Childress said.
Harvin's injury further compounded a bleak state of affairs at receiver for the Vikings.
Bernard Berrian was added to the injury report on Friday with a groin strain. Berrian was made active for the game, but he apparently suffered a setback in warmups, according to Brett Favre.
"He was set to go. We had him up and I knew it was bugging him a little bit, but he said he needed to go," Childress said.
Berrian wrote on his Twitter page that he played through the injury last week and took offense at people that were questioning his toughness or heart.
When it came to game time, Berrian wasn't going. He was sidelined for the entire game, joining backup QB Tarvaris Jackson as the only active players that didn't play.
"You like to have all those playmakers. It was going to be Greg Camarillo and Bernard Berrian and Hank Baskett and Greg Lewis - we have five up for a reason," Childress said. "We like to have five in some of those packages. It's football. We had enough to play."
Barely. By the time the Vikings needed their receivers for the hurry-up offense in another attempt at a fourth-quarter comeback, they were left without Berrian and Harvin.
Last year's Pro Bowl receiver, Sidney Rice, wasn't added to the 53-man roster on Saturday as his attempt to come back after hip surgery on Aug. 23 continues.
"We went through yesterday morning to see how he came back from Friday's practice and I'm not going to say we went until the 3 p.m. deadline, but we had a mock game yesterday morning and just talked to him," Childress said.
Rice is eligible to continue practicing with the Vikings this week, but they will have to make a decision on his roster status by next week – either elevating him onto the 53-man practice squad or placing him on injured reserve.
The Vikings had six sacks through seven games, but they appeared to be back on track after a six-sack performance against the Arizona Cardinals and Derek Anderson last Sunday. That momentum didn't continue into the Bears game.
Jared Allen registered the only sack of the game – for either team – but the Vikings weren't getting consistent pressure on Cutler.
"I'll have to go back and watch film to look at the whole thing, but I thought there were times we were definitely making him run more than just sitting back with the ball," Allen said. "You've got to make plays on the ball."
The overwhelming statistic for the Vikings was the incredible success the Bears experienced on third downs. They entered the game ranked worst in the league converting third downs, but they didn't look like it against the Vikings, converting an impressive 58 percent of their attempts, more than double their season average.
"At the simplest level, you have to be able to stay on the field offensively, and you have to be able to get off the field on the defensive side of the football. That was a struggle for us," Childress said.
On the other hand, the Vikings only converted 11 percent – just one of nine third-down attempts.
"People ask about third downs and I think there were nine; seven of them were double-digit third downs, which lends itself to first- and second-down issues, lost-yardage plays, or certain yardage plays or incompletions," Childress said.
Childress was close. Six of the Vikings' nine third-down plays were third-and-10 or longer.
Brett Favre is never short on verbiage, but he had a couple of interesting answers during an interview with his former quarterbacks coach from their early days in Green Bay, Steve Mariucci, now of NFL Network.
Last year, Childress considered benching Favre on a couple of occasions, so what is their relationship like this year?
"About the same (as last year). A lot has been made of it. I think a lot of it has been blown out of proportion," Favre said. "Brad's a good guy. My dealings offensively are with Darrell Bevell, offensive coordinator. It's a good relationship. I have no problems with Brad."
Last Sunday, Favre threw for a career-high 446 yards and led the Vikings on their biggest fourth-quarter comeback in franchise history, leading the offense to two touchdowns in the final four minutes.
"It's got to be top five and it has nothing to do with the amount of yardage even though that's the most yardage I've ever thrown for," Favre said.
He also said he hasn't heard a word recently on the NFL's investigation into allegations that he sent inappropriate texts and pictures to former New York Jets employee Jenn Sterger, a potential violation of the league's personal conduct policy. He could face a potential fine or suspension, but he said it hasn't been too tough to deal with.
"Not that difficult. Our season has been a struggle. As I've said before, let the league do its due diligence and in the end that will sort itself out," Favre said.


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Important information about Fund performance
Fund Manager since
Standard Fact Sheet
Expanded Fact Sheet - Institutional Shares
Quarterly Letter 2Q16
The Review and Outlook for period ending September 30, 2016 is not yet available
Shares of Amazon.com, Inc., the world's largest retailer and cloud services provider, rose in Q3 after reporting strong revenue growth and improving margins in its core business. Amazon's other major business segment, Amazon Web Services (AWS), continues to gain traction with enterprise customers, and had another strong quarter of growth. Over time, we expect AWS to be the larger contributor to value creation. The company continues to invest in new and potentially large business segments such as e-finance, business supplies and apparel.
Shares of Alibaba Group Holding Limited, the largest e-commerce company in China, performed well in Q3 following strong quarterly results. Enhanced financial disclosure helped investors to understand better the profitability of the core commerce business and thereby attribute a higher value to it. We expect that mobile monetization will continue to improve through 2016 and beyond as the company invests in new areas such as online grocery and cloud computing.
Shares of Illumina, Inc., the leading provider of DNA sequencing technology to academic and commercial laboratories, contributed to performance in Q3. The company reported financial results that beat Street expectations and reiterated guidance for the year. We continue to believe Illumina has a long runway for growth, driven by increasing adoption of DNA sequencing in clinical markets such as cancer screening, diagnosis, and treatment.
Bristol-Myers Squibb Company is a large diversified pharmaceutical leading the development of immune stimulating therapies for oncology. These efforts are spearheaded by its product Opdivo, now approved to treat several types of cancer. After positive data was released on a rival drug to treat first-line advanced non-small-cell lung cancer, Bristol-Myers revealed that Opdivo did not meet the primary endpoint in a Phase III trial in the same indication, and shares fell. We are analyzing the competitor's trial results and Bristol-Myers data sets.
This quarter saw pressure in the data center segment, and Equinix, Inc. was no exception. Slowing industry activity and cautious management commentary spurred some profit taking ahead of Q3 earnings. We like the growth prospects for Equinix and think management has a clear and sensible plan to keep growing at a relatively higher pace while improving efficiencies and demonstrating margin leverage. We view 2016 as a digestion year, with two acquisitions and a divestiture, and expect 2017 to show significant leverage to shareholder profitability.
Shares of cybersecurity software vendor FireEye, Inc. fell in Q3 on disappointing guidance as new management reset expectations for 2016 in an effort to build a solid base for 2017. We believe management is building a strong foundation for future growth. The organization has been right-sized, mid-market and new subscription products are being launched, and go-to-market partnerships have been fine tuned. FireEye has best-in-class technology and is improving its delivery methodology in products (subscriptions) and go-to-market design.
When reviewing performance attribution on our portfolio, please be aware that we construct the portfolio from the bottom up, one stock at a time. Each stock is included in the portfolio if it meets our rigorous investment criteria. To help manage risk, we are aware of our sector and security weights, but we do not include a holding to achieve a target sector allocation or to approximate an index. Our exposure to any given sector is purely a result of our stock selection process.
Baron Fifth Avenue Growth Fund increased 10.16% in the third quarter and outperformed the Russell 1000 Growth Index by 558 basis points. During the quarter, stock selection and, to a lesser extent, relative sector weights lifted relative results.
Consumer Discretionary, Health Care, and Information Technology (IT) investments and lack of exposure to the lagging Consumer Staples sector, which fell 4.9% in the index, contributed the most to relative results. Within Consumer Discretionary, outperformance of internet & direct marketing retail holdings Amazon.com, Inc. and The Priceline Group, Inc. and larger exposure to this strong performing sub-industry added the most value. Amazon was the largest contributor to absolute results, while shares of leading online travel agency Priceline rose on strong Q2 results and a robust outlook for Q3. Naspers Limited, a South Africa-based internet and media platform operator, also contributed to relative performance due to its large ownership position in Tencent Holdings Limited, whose stock price rose more than 20% in the quarter. Strength in Health Care was mostly attributable to the outperformance of Illumina, Inc., the third largest contributor on an absolute basis, and biotechnology holdings Biogen, Inc. and Regeneron Pharmaceuticals, Inc. Within IT, outperformance of internet software & services holdings, led by Alibaba Group Holding Limited and Alphabet Inc., and significantly larger exposure to this better performing sub-industry contributed the most to relative results. Alibaba was the second largest contributor to absolute performance, while shares of leading search and online advertising company Alphabet were up in the quarter, driven by quarterly results that surpassed Street expectations. Payment networks Mastercard Incorporated and Visa, Inc. also aided relative performance.
Larger exposure to the underperforming Real Estate sector, which was hurt by the poor performance of REITs, detracted the most from relative performance.
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The prospective performance of the companies discussed herein is based on our internal analysis and reflect our opinions only. We cannot promise future returns and our opinions are a reflection of our best judgement at the time of publication. Our views are not intended as recommendations or investment advice to any person and are subject to change at any time based on market and other conditions and Baron has no obligation to update them. Investing in the stock market is always risky. Investing in the stock market is always risky. Current and future portfolio holdings in the Fund are subject to risk.
Source: FactSet PA.
You should consider the investment objectives, risks, charges, and expenses of any of the Baron Funds carefully before investing. The prospectus contains this and other information about Baron Funds. You may obtain one from its distributor, Baron Capital, Inc., by calling 1-800-99BARON or click here. Please read it carefully before investing.
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The captain of the sunken South Korean ferry has been charged with manslaughter following the disaster that has left more than 300 people either missing or dead.
The Sewol's chief engineer, first officer and second officer have also been indicted on the grounds of gross negligence, prosecutors said. If convicted the four men face life imprisonment.
Captain Lee Joon-seok was one of the first people to escape from the sinking ship when rescue boats arrived. He also took around half an hour to issue an evacuation order, and there is some doubt as to whether his message ever got through to passengers.
Of 476 passengers and crew on board the ship, just 172 were rescued – including 22 of the 29 crew members. Prosecutors have also indicted another 11 of them on less severe charges of negligence.
A month after the disaster, 281 bodies have been recovered but 23 people remain missing, with the deteriorating condition of the vessel making the ongoing recovery effort increasingly difficult.
South Korea ferry disaster
South Korea ferry disaster
1/6 South Korea ferry disaster
A woman ties a yellow ribbon dedicated to dead and missing passengers onboard sunken passenger ship Sewol to a pillar at Yellow Ribbon's Garden set up at Seoul City Hall Plaza
2/6 South Korea ferry disaster
A South Korean man walks past a well-wishing ribbon in Seoul
3/6 South Korea ferry disaster
High school student who are members of the Youth section of the Seoul Alpine Federation, climb to display a sign reading 'My dear friend I will remember you forever' while hoping for the safe return of the sunken ferry Sewol's missing passengers as they hang on a rope bridge on the Ansan mountain in Seoul
4/6 South Korea ferry disaster
High school student hold a sign reading 'My dear friend I will remember you forever' while hoping for the safe return of the sunken ferry Sewol's missing passengers as they hang on a rope bridge on the Ansan mountain in Seoul
5/6 South Korea ferry disaster
File image: A diver gets out from the sea after attempting to search for the missing passengers at the site of the sunken South Korean ferry 'Sewol' off Jindo on 26 April, 2014
AFP/Getty Images
6/6 South Korea ferry disaster
South Korean coast guard officers try to rescue passengers from the Sewol ferry as it sinks in the water off the southern coast near Jindo, south of Seoul, South Korea
When it set sail on 16 April, the Sewol's stability was severely compromised following a recent remodelling to add capacity, prosecutors said. When it sank it was also heavily overloaded and did not have enough water in its ballast tanks to keep it steady.
Investigators say strong currents in the disaster zone made the vessel less responsive to navigation and prompted the crew to make a turn of 15 degrees, sharper than would be advisable, which led the ferry to list rapidly and then sink.
Prosecutor Ahn Sang-don said: "The captain should have been in command of the navigation, but left that to a third officer, and that is gross negligence," adding there was enough evidence to support a charge of wilful negligence on the part of the captain and three other officers.
"The charge of homicide was applied because they did not exercise their duty of aid and relief, leading to the deaths of passengers," he said. Ahn also revealed that some crew had confessed that "they were thinking about their own lives".
The Sewol was on a routine journey from the mainland port of Incheon to the southern holiday island of Jeju when it sank, and included in its passengers 339 students and teachers on a single school trip.
The government of President Park Geun-hye has faced sharp criticism for its handling of the disaster and the rescue effort, with an outpouring of anger over suggestions that a more effective initial response could have saved many more.
Authorities have also said they fear that the owner of the ferry's operating company, Chonhaejin Marine, may attempt to flee the country.
Yoo Byung-aeon is due to appear for questioning on Friday but has gone into hiding with his four children, who also have positions in the company.
A prosecution spokesperson told the Chosun Ilbo newspaper: "We are not talking about a petty criminal, but a man who is the son of a religious leader, a renowned artist and a major shareholder in multiple businesses. He just fled immediately after being summoned for questioning."
Prosecutors also said they were investigating officials of a number of shipping inspection agencies. They said the crew members' first court dates have yet to be finalised.Reuse content


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Carnival Breeze Cruise Review by cappacino: The Carnival Breeze is wonderful!!!!
Overall Member Rating
The Carnival Breeze is wonderful!!!!
Destination: Eastern Caribbean
Embarkation: Miami
The Carnival Breeze ship is wonderful!!! The ship was clean and a pleasure to be on. The crew were super nice and friendly!! The food was excellent!! My children loved it so much!!! They smiled all the time!!
The entertainment was great!! The waiters dancing was the best!!
Our stewardess was sooooo nice!! Lots of nice towel art and a friendly hello everytime we met!!
I loved the spa and the workout facilities!! Very clean with lots of disinfectant bottles to clean the equipment.
I am prone to sea-sickness and I did not get sea-sick once, neither did my kids!!
The only issue I had was deck chairs. I sat down in empty chairs and people stated that they were sitting there. Well, if your not in it, too bad for you. But it didn't get me down. I didn't sit down very often, I was too busy swimming in the pools, jacuzzi, and walking around taking in the sights! I can watch the ocean go by, forever!! Less
Published 02/06/13
Read more Carnival Breeze cruise reviews >>
Read Cruise Critic's Carnival Breeze Review >>
Cabin review:
The Spa Cloud 9 cabin was wonderful!! I love having a balcony!! Access to the spa was wonderful!!
Port and Shore Excursions
Allure is Amazing!
Fun for Kids
Good and Not So Good
Very Disappointed;Allure of th...
Breeze to Belize for rest and ...
Much improved!
Breeze was Breezy Fun!
Very Nice Trip
One giant 3-day floating party...
Mother and Daughter Weekend Cr...
Family Cruise Fun
Do the hurricane!
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