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Operation: BLACK TIDE
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| Capitalization
The way the Ratchet & Clank wiki capitalizes words has changed; therefore, this article should be checked, and, if necessary, capitalization should be fixed.
Operation: BLACK TIDE was the mission the Galactic Rangers were assigned on Rilgar during Dr. Nefarious's reign. It involved capturing the Tyhrranoids base to stop their invasion on Blackwater City. Ratchet was given the Gravity Boots for helping them, which were needed later in his adventure.
- Ratchet & Clank: Up Your Arsenal (first appearance)


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Verizon FIOS In My Area – Featuring FiOS Internet,TV and phone
FIOS bundles include phone service, high speed internet and television service. Verizon bundles featuring fiber optics to your door to bring you fast and reliable internet access in addition to sharp television and digital phone service. In some cases, it is possible to buy a higher-tier bundle at a lower price than a lower-tier bundle with certain a la carte options. Verizon FiOS is the first fiber optic service available to consumers that brings fiber to your home.
Verizon FIOS In My Area – Call 1-877-849-3962 – Verizon FIOS
Home phone service is also included in the Verizon FiOS Triple Play package, and it offers crystal clear connections no matter where the call goes to. Verizon FiOS internet is the final component to the Triple Play package, and it has remarkable speeds and is one of the most reliable connections available anywhere. Verizon FiOS Triple Play can save you a bundle of cash. Additionally, 35Mbps synchronous broadband speeds are available, and it is worth noting that over 2800 monthly on demand offerings are presented in HD. While both FiOS Internet and FiOS TV can be ordered as standalone products, Verizon provides significant discounts to customers that bundle services. FiOS uses a passive optical network to distribute service. Initial FiOS installation used BPON transfer mode where a single fiber optical cable is capable of 155 Mbps upstream, and 622 Mbps downstream.
Verizon FiOS TV Service Wins Awards
Verizon FIOS In My Area Verizon Fios offers the best premium channels that cable has to offer, from HBO, Cinemax, Showtime, and many more. The Verizon FiOS TV service is ranked number one by HD consumers and is the most often recommended TV service by technology experts.
Fiber optic technology gives unbelievable picture and sound with its huge pipe of data transfer. The DVR makes it possible to watch all of your favorite television shows at your own convenience, and you can even watch them in HD to make the experience even more enjoyable. Verizon Fios really has everything cable subscribers could ever want or need. Some of the most popular international channels are available on Verizon Fios, including channels from Italy, Japan, and even France. With everything from local cartoons, to news programs and even soap operas, you can catch up on everything going on in your homeland from you own couch.
Fast Internet Access – Direct Connection
Verizon FiOS is the first Internet provider to take advantage of new technology which takes fiber-optic connections right into your home, all the way to your computer. Verizon Fios broadcasts with a 100% fiber optic network, which provides a complete digital picture that is sure to impress. The fiber optic network provides both crystal clear picture and sound that are like no other, which makes every single channel look and sound absolutely amazing.
Check Availability Online: Verizon FIOS In My Area
The good news is, you do not need to pay more for Verizon FiOS; in fact, you'll pay less. With packages starting at $42.99, Verizon FiOS is faster, better, and cheaper than cable or DSL. It's great for ultra-fast surfing. You can also surf & talk at the same time. Verizon High Speed Internet does both on the same line. Verizon FIOS In My Area The aforementioned prices offered to all FiOS customers regardless of area, but some areas actually have lower pricing. Installation is free with a one-year contract and priced without a contract. Verizon also adds features over time, such as widgets, that may offer additional functionality over the web at no additional charge.
Verizon FIOS In My Area Includes Save On Your Home Phone
With rates ranging from $39.99 – $56.99, you can choose the one that caters to your particular calling needs and enjoy a great selection of calling features. Technically FiOS Digital Voice is a VOIP service, but will likely provide a much more reliable connection and higher quality of service than what is traditionally expected from VOIP service. Verizon FIOS In My Area

subset: commoncrawl


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South Korea's struggling households aren't keeping pace with overall growth in national income, the Bank of Korea reports. In fact, households' share of total income fell 8.9 percentage points between 1995 and 2011, twice the decline reported on average for members of the Organization for Economic Cooperation and Development.
Full Story:The Korea Herald (Seoul)


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Guy Pope, manager of the Columbia Contrarian Core fund, keeps a color-coded Excel spreadsheet ranking the fund's 69 holdings that is updated daily. The stocks that have the highest appreciation potential are on the top of the list, and those that are closest to their target price are on the bottom. By focusing on that rainbow sheet to determine what and when to sell, Pope keeps himself from getting caught up in the emotions that can derail even the best of investors.
"It's something I've done my whole career, and I can't imagine running a portfolio without it," Pope says. "I take it home with me every night, and go over the price targets."
Pope, 48, a longtime resident of the Pacific Northwest and an avid runner, approaches his $4.6 billion fund (ticker: LCCAX) with the discipline of someone training for a marathon. He sticks to his process, regardless of what the market may be doing.
Manager Guy Pope looks for unloved companies, regardless of sector, for his Columbia Contrarian Core fund. Photo: Craig Mitchelldyer for Barron's
Pope's stock-picking strategy begins with a screen of stocks, primarily from the Russell 1000 index, that have a market value of $2 billion or more and are trading in the bottom third of their 52-week price range. Recently, that screen turned up 250 stocks. "In good times, that can shrink to 100 names," Pope says. "And when there's a very deep selloff, such as the fourth quarter of 2008, it will get to over 900 names."
Then, Pope and his Portland, Ore.-based team—Harvey Liu, Michael Welter, and Nicholas Smith—start digging into the companies one by one. What they're looking for: stocks hated by others—regardless of whether they're growth or value—that their research has determined will be able to recover. With a concentrated portfolio—the top-10 holdings account for nearly 30% of assets, and the top holding, Apple AAPL -2.2494714587737845% Apple Inc. U.S.: Nasdaq USD115.59 -2.66 -2.2494714587737845% /Date(1477515600286-0500)/ Volume (Delayed 15m) : 64487534 AFTER HOURS USD115.54 -0.0499999999999972 -0.04325633705337832% Volume (Delayed 15m) : 1646685 P/E Ratio 13.977025392986699 Market Cap 622850091736.659 Dividend Yield 1.9724889696340513% Rev. per Employee 1960350 More quote details and news » (AAPL), for more than 5%—they like to buy and hang on to companies. Turnover is 47%, versus the category's average of 61%, according to Morningstar.
Pope got his bachelor's in political economics at Colorado College before going to Northwestern's Kellogg School of Management for his M.B.A. He joined Columbia in 1993 and stayed for 21 years as the firm morphed from a privately held shop with some $20 billion in assets to a subsidiary of Ameriprise Financial AMP -7.302272961020261% Ameriprise Financial Inc. U.S.: NYSE USD90.13 -7.1 -7.302272961020261% /Date(1477515652664-0500)/ Volume (Delayed 15m) : 2705322 AFTER HOURS USD90.2 0.0700000000000074 0.07766559414179519% Volume (Delayed 15m) : 5181 P/E Ratio 12.245923913043478 Market Cap 14548874759.7385 Dividend Yield 3.3285254632197936% Rev. per Employee 759154 More quote details and news » (AMP) with more than $350 billion under management. He has been managing Columbia Contrarian Core since 2005.
"Guy is incredibly regimented in all facets of his life—he eats the same thing for breakfast every day," Liu says. Recalling his move from Singapore to Portland, Liu adds, "Guy knew that I was trying to get back in shape, so he invited me to run with him on one of his favorite trails. I envisioned that we would talk about stocks and the markets, but 10 or 15 minutes into the run, he just took off and left me in the dust."
Pope's discipline and strategy have left his competitors in the dust, too: Columbia Contrarian Core has beaten 98% of its large-blend peers over 10 years, up an average of 10.2% annually, versus the large-blend category average of 7.6%, according to Morningstar. He's also beating 84% of his peers over five years.
Pope's contrarian approach has worked well in both up and down markets. In 2007, when the market was strong and emerging markets were hot, Pope's research led him to high-quality companies. Then, as the bear market began, the names on Pope's screen grew to more than 900, and he started buying financial companies such as Wells Fargo wfc 0.9405074365704287% Wells Fargo & Co. U.S.: NYSE USD46.15 0.43 0.9405074365704287% /Date(1477515669944-0500)/ Volume (Delayed 15m) : 25046822 AFTER HOURS USD46.18 0.0300000000000011 0.06500541711809317% Volume (Delayed 15m) : 135078 P/E Ratio 11.366995073891626 Market Cap 229697286132.812 Dividend Yield 3.293607800650054% Rev. per Employee 359358 More quote details and news » (WFC), and other stocks that had been pummeled—setting up the fund to outperform in 2009. "Going to what's out of favor can help you," says Pope, who has a "significant" amount of his own money in the fund.
Consider Citigroup C 0.8469449485783425% Citigroup Inc. U.S.: NYSE USD50.01 0.42 0.8469449485783425% /Date(1477515664344-0500)/ Volume (Delayed 15m) : 13827854 AFTER HOURS USD49.91 -0.100000000000001 -0.19996000799840033% Volume (Delayed 15m) : 132180 P/E Ratio 10.86158590882436 Market Cap 142528495216.37 Dividend Yield 1.279744051189762% Rev. per Employee 367519 More quote details and news » (C), the epitome of an out-of-favor stock and the fund's fourth-largest holding. It has had a number of high-profile troubles this year, from failing its stress test to the discovery of fraud in its Mexican unit. Pope figures that things can only go up: He expects Citigroup to pass its next stress test, and argues that as interest rates move higher, sentiment on financial stocks will improve. Plus, at 0.85 times tangible book value, the shares are a bargain, he says, adding, "Little has gone right for them this year, and the stock is down. I think it is clearly contrarian now, and very intriguing from this valuation level."
Columbia Contrarian Core
|Total Returns*
|% Of
|Top 10 Holdings
|JPMorgan Chase
|Verizon Comm.
|CVS Caremark
|Johnson & Johnson
|Procter & Gamble
|Philip Morris Intl
|Comcast (Class A)
|*All returns are as of 7/9; three- and five-year returns are annualized.
** As of 05/31.
Source: Morningstar
Another stock Pope likes is Verizon Communications VZ -0.4389632107023411% Verizon Communications Inc. U.S.: NYSE USD47.63 -0.21 -0.4389632107023411% /Date(1477515605141-0500)/ Volume (Delayed 15m) : 14076692 AFTER HOURS USD47.6 -0.0300000000000011 -0.06298551333193365% Volume (Delayed 15m) : 972515 P/E Ratio 13.845930232558139 Market Cap 195009622653.242 Dividend Yield 4.849884526558891% Rev. per Employee 719719 More quote details and news » (VZ), the telecommunications company that recently completed a deal with Vodafone Group (VOD). "Vodafone shareholders over time are not natural holders of Verizon stock. We thought that would create some selling pressure on Verizon, and we believe it did," Pope says. The stock is now the fund's third-largest holding. Shares recently traded at 13 times next year's consensus estimates, and sported a dividend yield of 4.3%. "It was a company selling at a discount to the market with a much higher-than-average dividend yield," Pope says. "We think that it will perform well in this slow-growth environment."
He also sees opportunities in biotech as the sector's selloff added a number of once-expensive names to his screen. Pope particularly likes Celgene CELG 0.7989347536617842% Celgene Corp. U.S.: Nasdaq USD98.41 0.78 0.7989347536617842% /Date(1477515600153-0500)/ Volume (Delayed 15m) : 4783166 AFTER HOURS USD98.99 0.579999999999998 0.5893709988822274% Volume (Delayed 15m) : 233683 P/E Ratio 41.17573221757322 Market Cap 76279069027.5207 Dividend Yield N/A Rev. per Employee 1423100 More quote details and news » (CELG), recently at about $87, whose flagship product, Revlimid, which fights blood cancers, has been the subject of a patent dispute. "It got swept up in the momentum selloff in the second quarter and the biotech selloff of the second quarter," says Pope, who added to his position in the low $70s. "We feel good about the intellectual property as surrounds Revlimid." Earnings are expected to reach $7.50 per share in 2017, a 25% annualized growth rate—and Pope sees prospects beyond 2017.
His portfolio of household names may not seem all that contrarian at times. "People look at our holdings, and say, 'Hey, there's nothing really contrarian about that name,' but if we buy contrarian stocks and sell them when they're contrarian we wouldn't create alpha," Pope says. "We buy them when they are contrarian and sell them when they are fully valued."
Pope will also use his rainbow sheets to pare names. If a stock falls 15% from its purchase price, he'll cut a third of the holding and gather the team to reassess the name from scratch. In fact, he figures the team spends more time ensuring that the current holdings deserve to stay there than trying to come up with new stocks to buy.
"The thing I like about our process is, it's not too complex," Pope says. One of the biggest keys to success is blocking out the noise and making sure you're buying and selling on your own timetable. As Pope says, "It's a pretty simple, disciplined process, and simple and disciplined is good in this world."
E-mail: email@example.com


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Dec 15, 2006 11:19PM PST
well, its 11:00pm I'm at the ziff office, its quiet because i'm the only one here. waiting for the broken pixels show to finish uploading to gamevideos. me and cesar have been up since thursday editing the show. happy friday enjoy the show kids I'm going to sleep.
Comments (30)
It's about time!Posted: Dec 15, 2006 12:00AM PST by Coyotegrey
I love Broken Pixels and I was starting to wonder what the hell happened to it.
Thank youPosted: Dec 15, 2006 12:00AM PST by Player Bob
Your work is greatly appreciated!\
**Runs to go watch the mocking
One thing is for certain...Posted: Dec 16, 2006 12:00AM PST by shigamado
You guys do NOT know how to play Red Steel.
You wait for the guy to attack you with his sword, then shake the left nunchuck to parry him and knock him back. Then you can strike him.
Good show all around though. I remember trying Necronesia at E3. It was by far the worst game there.
as alwaysPosted: Dec 16, 2006 12:00AM PST by mad_hatter_d
great stuff
Necronesia taught me...Posted: Dec 16, 2006 12:00AM PST by palaeomerus
...that snake handlers don't love Jesus as much as roach handlers.
Very funnyPosted: Dec 16, 2006 12:00AM PST by evil_keebler_elf
Nice job Jason and Cesar
hahahaPosted: Dec 16, 2006 12:00AM PST by Circle_Strafe
That was a great thing to start the morning
A tremor in the forcePosted: Dec 16, 2006 12:00AM PST by JD-Ure
As a million fanboys cried out in pain. The score is down in the sevens, presumeably because it's not funny to make fun of the wii, but did you hear the one about the wiimote recall? "It's almost twice as big"(Nintedo explaining the companies fix for wiimote strap)great so now it's as big as TWO pubic hairs!
I love the show, and think it's the best thing on 1up. I also like the idea of mocking more current games,as well as waxing nostalgiac about bad games of the past.
How about-Hooters Roadtrip, Narnia, any That's so Raven game, or Barbies Horse Adventure.
One more Idea is you guys could do a MST3k kind of thing with movies. Maybe start with The Wizard, Streetfighter,and Mortal Kombat 'films', before branching out into other genre types(any one of the sci-fi channels original movies about a computer generated snake/dragon would be fun).
Anyway thanks for working so hard Jason.
Hahaha.Posted: Dec 16, 2006 12:00AM PST by Jakeratboy
The good news is they're making a sequel.
best nintendo game ever...Posted: Dec 16, 2006 12:00AM PST by mikemarshall17
That sword fight is classic.
Good Job!Posted: Dec 16, 2006 12:00AM PST by moethechaste
Thanks for giving me something to do for 30 minutes or so. You guys at 1Up rock.
Hoo ahh!Posted: Dec 16, 2006 12:00AM PST by A.I_Impaired
Awesome work. I enjoyed the show quite emensely.
What got me was that they actually put necro-nesia, a game that isnt even out in the americas yet, so we already know its crap before it hits our shores. Im surprised, as id figure you guys would be getting crap about it. None the less it was purely entertaining, and im all the more glad I didnt buy Red Steel.
I got in trouble!(Well, not really.)Posted: Dec 16, 2006 12:00AM PST by Canesfan3301
Okay, I'm at work right now(I'm in the Navy, with the Military Police), and I'm catching up on work e-mails and surfing 1up, when I read about a new Broken Pixels episode. So I watch it, and I was laughing so loud and hard in my cubicle, that my supervisor thought I was having a seizure. When he found out I was just watching Broken Pixels, he just shook his head, and yelled at me to get back to work. I'll get back to work, but now I'm gonna go to Game Videos and re-watch all the Broken Pixel episodes. What else do I have to do here at the precinct besides work e-mails, and issuing weapons? Not freaking much, I'll tell you that. But don't tell my supervisor that. Jason, Ceasar, great freaking job!
Hilarious...Posted: Dec 16, 2006 12:00AM PST by JolietJake
I think this is one of my favorite Broken Pixels, great job.
More episodesPosted: Dec 16, 2006 12:00AM PST by theswankster
That episode was hilarious, you guys have to make more of 'em!
I can relatePosted: Dec 17, 2006 12:00AM PST by Coyotegrey
After going through a similar ordeal for finals...
much respec...dawg.


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I am based in Cherokee County and work the Alpharetta area often. First, if you have submitted an offer on a property, then you may have had an agent. I would not want to interfere with that relationship if so. If not, then, of course, I would need more info to answer your question intelligently. If you presented an offer like the gentlemen suggested below to a listing agent then your interests were not represented, but it doesn't mean the offer was not submitted. Not having a fiduciary responsibility doesn't mean the agent isn't ethically obligated to treat you fairly as a "customer." If you can provide me with some more information I can answer your question better. If this house does sell to someone else, you may have learned a valuable lesson of the need to be represented by a highly qualified real estate professional that will represent your interests and work for you! I think I might just know one who will :-).
Give me a call and I will promise to do the very best I can for you!
David Brower, Assistant Manager/Realtor
Crye-Leike Realtors
Did you present the offer to the listing agent (who's name appears on the listing or lawn sign)? I don't practice law, but my interpretation of our roles as agents is that all offers must be presented to the owner. If you worked directly with the listing agent, you are considered a customer and the listing agent has no fiduciary responsibility to tell you anything at all. In many cases, we agents will have to overcome several barriers to determine if the offer was accepted, much less presented.
Working with your own agent usually costs you nothing, but it can help you with frustrations like this. Please call if I can be of assistance.
Solomon Greene
REALTOR® / Consultant - Keller Williams Realty Atlanta Partners Duluth
(678) 775-2677
If you will call me and give me the info, I will check on this for you.
Dori Glawson
RE/MAX Center


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You could say that Ireland Baldwin's got some good genes. The 16-year-old progeny of Alec Baldwin and Kim Basinger's got the attractive gene from both sides of the family, but really, really, really takes after mum Kim.
Like, majorly.
Ireland was photographed out and about in Manhattan and has the same wavy blonde mane and blue eyes as her actress mother, whose breakout role was as a Bond Girl in Never Say Never Again and who won an Oscar for her role in L.A. Confidential.
Are mum and daughter doppelgängers or what? Let us know what you think and check out more celeb blondes below.
By Jennifer Barton
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Dubai City Tour and Desert Safari with BBQ Dinner
See the old and new sights of Dubai, then travel across the desert sands on a combined 9-hour city tour and desert safari. Learn more about Dubai's…
Duration: 9 hours
From $109
Likely to sell out
DubaiSee all 523 tickets & tours
Want to discover all there is to do in Al Fahidi Fort? Click here for a full list.


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Edit your search:(X) Englewood Cliffs, NJ
Yes (amount not posted) Draw against commission At least $10,000 At least $20,000 At least $40,000 At least $60,000 At least $80,000 At least $100,000
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Englewood Cliffs Sales Jobs in New Jersey
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The Home Depot - Englewood Cliffs, NJ
Watch Our Home Services - Outside Sales Consultant Video Position Purpose:Sales Consultants are primarily responsible for selling Home Depots do-it-for-me services to clients in their homes. Sales Consultants spend the majority of their time traveling to and engaged in professional sales presen ...
Posted: 2016-10-18 | Industry: Retail Sales | Base Salary: Yes (amount not posted)
Outside Sales Representative
Auto-Chlor System - Englewood Cliffs, NJ
Great Jobs...Great Stability...Great Benefits...GREAT CAREERS. Auto-Chlor System is a nationwide leader in the hospitality equipment and cleaning products arena. We help restaurants of all sizes clean and sanitize their dishware and kitchens. Our team members help protect the dining public from d ...
Posted: 2016-10-02 | Industry: Professional Services | Base Salary: At least $20,000
Sales Representative / Sales Manager
Carter-Brinley Group - Englewood Cliffs, NJ
Carter Brinley Group is a Real Estate Investment firm looking to hire individuals to help expand its reach nationwide. We believe in educating clients on the power and value of real estate as a tool to personal financial security. We have partnered with the leading Real Estate Investment Educatio ...
Posted: 2016-10-21 | Industry: Sales Recruiter | Base Salary: Yes (amount not posted)
Business and Education Sales Leader
Carter-Brinley Group - Englewood Cliffs, NJ
If you have a background in Sales, Marketing, Advertising, Education, Finance, Distance Learning, Recruiting and/or Personal Development, this opportunity could be a dream come true for you. We are recruiting sales professionals to earn lucrative commissions reaching out to entrepreneurs, busin ...
Posted: 2016-10-14 | Industry: Professional Services | Base Salary: Yes (amount not posted)
Account Executive - Sales
Western Pest Services - Englewood Cliffs, NJ
Western Industries is a premier service provider offering solutions to multiple industries. This business-to-business outside sales opportunity focuses on industries including healthcare, hospitality, food processing, commercial real estate, and more. Established in 1928, we have a legacy of exc ...
Posted: 2016-10-17 | Industry: Professional Services | Base Salary: Yes (amount not posted)
Sales Representative / Sales Engineer
Handi-Lift Inc. - Carlstadt, NJ
ABOUT US Handi-Lift is the leading accessibility contractor in the Tri-State area. With products like wheelchair lifts and home elevators, we create solutions that enable people with mobility impairments to live freely. We provide one-on-one design and code consulting, a broad product range, expe ...
Posted: 2016-10-15 | Industry: Construction | Base Salary: At least $40,000
Outside Sales Executive
Auto-Chlor System - Carlstadt, NJ
Great Jobs...Great Stability...Great Benefits...GREAT CAREERS. Auto-Chlor System is a nationwide leader in the hospitality equipment and cleaning products arena. We help restaurants of all sizes clean and sanitize their dishware and kitchens. Our team members help protect the dining public from d ...
Posted: 2016-10-05 | Industry: Manufacturing | Base Salary: Yes (amount not posted)
Inside Sales
Steiner Sports - New Rochelle, NY
The Company Steiner Sports is the leader in sports memorabilia and marketing. The company is renowned for its extensive cadre of relationships with premier athletes and for creating authentic, quality memorabilia that is sold through multiple channels. The company also operates retail stores in R ...
Posted: 2016-10-21 | Industry: Merchandise | Base Salary: At least $60,000
Sales Reps. Home Improvement Products.
Sears Home Improvement - New Rochelle, NY
-All Leads provided, pre-qualified and confirmed -NO cold calling -NO cap on commission earning -Fuel reimbursement program -Company provided laptop for in-home presentations -Paid training Now that I have your attention, lets talk about the position. The Outside Reps are subject ...
Posted: 2016-02-04 | Industry: Construction | Base Salary: 100% commission
Sales Rep
Seamen's Moving and delivery of Connecticut inc - New Rochelle, NY
We are the leading moving company in the try state area for the last 16 years. We are currently seeking a highly motivated individual with a natural aptitude for sales . The candidate will be primarily responsible for communicating with potential clients and selling company services. In addition, ...
Posted: 2016-10-17 | Industry: Retail Sales | Base Salary: Yes (amount not posted)


text:
Though this year's BET Awards was jammed pack with celebs, all eyes fell to music icons Beyonce and Jay-Z when they arrived at Los Angeles' Shine Auditorium to take their seats next to Jay's Watch the Throne collaborator, Kanye West, and his girlfriend, Kim Kardashian.
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Just in time for the hectic shopping season, Google has rolled out a desktop app that many people venturing out on Black Friday will love – the ability to check if items are actually in stock at the store location they are going to!!
For the people who want to plan their attack on Black Friday Google's desktop availability checker should prove invaluable.
Google Retail Advertising Blog said it was "pleased to announce the launch of local availability results in Google Product Search on desktop. Search for a product and click on the "nearby stores" label, and you can easily find a list of stores to call to check availability, and in many cases, information about whether the product is in stock nearby".
"Our vision was simple: partner with retailers to organize all of the world's local product information."
No doubt Google is also hoping these retailer advertisers will love this enough to spend more money, but when combined with the mobile app to check if they have sold out while you were getting there it is very handy.
"Retailers can submit local inventory data directly to Google via a data feed, or they can use adaptors for their retail software built by JDA Software Corp., Epicor Corp. or Oracle Corp. to provide the data", Internet Retailer noted.
"The service, which is free for retailers, is open to merchants of all sizes. However, many on board now are large retailers with the sophisticated inventory management systems needed to provide Google with instant stock updates. Google says it will soon launch tools to help small and medium-sized businesses more easily share real-time inventory data so they can use the service as well," Internet Retail reported.
If you are going to battle the crowds you may as well go armed. Thanks Google
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text:
Van Morrison - Domino lyrics
Domino by Van Morrison
Don't want to discuss it
I think it's time for a change
You may get disgusted
And start thinkin' that I'm actin' strange
In that case I'll go underground
Get some heavy rest
Never have to worry
About what is worst and what is best . . . hit it
Oh, oh, Domino
Roll me over, Romeo, there you go
Lord have mercy, I said
Oh, oh, Domino
Roll me over, Romeo, there you go
Say it again
I said oh, oh, Domino
I said oh, oh, Domino
There's no need for argument
There's no argument at all
And if you never hear from him
That just means he didn't call
Or vice-a-versa
That depends on where ever you're at
And if you never hear from me
That just means I would rather not . . . hit it
Hey mister DJ
I just wanna hear some rhythm & blues right now
On the radio, on the radio, on, on the radio
On, on the radio, On, on the radio
On, on the radio . . . here's the band
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While the Affordable Care Act has cut the rate of uninsured Americans, it has not managed to bring down insurance prices.
Leaked emails show Clinton's advisers sought to ''develop a real relationship with'' the controversial private equity firm.
Visit NBCNews.com for breaking news, world news, and news about the economy


text:
Review Summary
- Spacious, modern rooms with free Wi-Fi
- Big, sunny outdoor pool with relaxing tropical decor
- Free hot breakfast every morning
- Quiet location walking distance to the beach
- Rooms have flat-screen TVs, mini-fridges, and microwaves
- Convenient outdoor shower at pool for rinsing off from beach
- Work desks with ergonomic chairs
- Jacuzzi suites offer tub and walk-in shower
- Not directly on the beach
- Very cramped fitness center
- Some dated furniture
Bottom Line
Holiday Inn Express Hotel & Suites South Padre Island is located on the quiet, northern end of the island. Spacious rooms are modern and offer free Wi-Fi, flat-screen TVs, mini-fridges, and microwaves. The resort has a big outdoor pool with relaxing tropical decor and an outdoor shower for rinsing off from the beach, but is lacking in other amenities -- including a decent fitness center. While this hotel is not located directly on the beach, it is only a three-minute walk away along a paved walkway. Additional perks include free breakfast every morning and convenient work desks with ergonomic chairs, but the rooms do lack dramatic views that other South Padre Island hotels offer.
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A relaxed scene with a tropical feel
This Holiday Inn Express lacks an oceanfront location, but is only a three-minute walk from the beach along a paved walkway. The hotel has a tropical feel, and like many of its competitors, the exterior is cheerfully painted in orange and yellow tones. The lobby is spacious with its high ceilings and second-story veranda overlooking the ground floor. Most relaxing takes place at the large outdoor pool with plentiful lounge chairs. There is also a covered bar area here and palapa-thatched drink tables, and palm trees add to the tropical feel.
On the northern end of South Padre Island's hotel sprawl, though not directly on the beach
This Holiday Inn Express is located at the northern end of South Padre Island's hotel sprawl, about a three-minute walk on a paved walkway from the beach. This hotel is close to local restaurants, although a car is necessary to get almost everywhere. Outdoor enthusiasts might appreciate the hotel's close proximity to Sea Turtle, Inc. and the South Padre Island Birding & Nature Center. Potential guests should be advised that all of the walking distances described below involve walking across or along a busy road without sidewalks.
- 65-minute-drive to Rio Grande Valley International Airport
- 6-minute-walk to South Padre Island Birding & Nature Center
- 6-minute-walk to Sea Turtle, Inc.
- 8-minute-walk to Andy Bowie County Park
- 8-minute-walk to South Padre Island Convention Center
- 10-minute-drive to Schlitterbahn Beach Waterpark
- 12-minute-drive to Port Isabel Lighthouse & Museum
- 49-minute-drive to Laguna Atascosa National Wildlife Refuge
Nearby Hotels
Clean, modern rooms with unexceptional views and no balconies
Spacious, modern rooms feature ochre shades against dark wood furniture. There are no views to get excited about, although some rooms on the highest floors have a slight view of the ocean in the distance beyond neighboring houses. There are no rooms with balconies here, but the beds are very comfortable with nice linens. The Jacuzzi Suites offer extra amenities, including the in-bathroom Jacuzzi tub and walk-in shower.
- Bathrooms are spacious and bright, with granite countertops.
- Comfortable beds with quality linens
- Large flat-screen TVs
- Coffeemakers with free coffee
- Mini-fridges and microwaves
- Free Wi-Fi
- No balconies
- Wet bars with granite countertops in some rooms
- Jacuzzi Suites feature walk-in shower in addition to Jacuzzi tub.
Rooms and Rates
Large outdoor pool and small fitness center
The highlight of the Holiday Inn Express Hotel & Suites is the large outdoor pool area, complete with tropical decor and a covered bar area. But the fitness center is unimpressive.
- Large outdoor pool with Jacuzzi and plenty of lounge chairs. Offers men's and women's restrooms and changing areas, as well as outdoor shower for rinsing off after the beach.
- Tiny, cramped fitness center with old cardio equipment
- Free business center
- Guest laundry facilities
- Sundry shop in lobby
- Free parking in lot fronting the property
- View Full List of Amenities
Free breakfast in the lobby dining area
- Free breakfast served daily.
- Coffee available around-the-clock
- Breakfast buffet includes cereals, milk, yogurt, juices, eggs, breakfast meat, biscuits, and pancakes.
- Microwave meals are available for purchase in lobby sundry shop.
- Several restaurants nearby
|Key Features
Fitness Center
|Hotel Services
Dry Cleaning
Free Breakfast
Rental Car Service Desk Onsite
|Family Services
Kids Allowed
|Things to Do
Business Center
Fitness Center
Located on the Beach
Tennis Court
|Room Features
Air Conditioner
Separate Bedroom / Living Room Space
|6502 Padre Blvd., Texas Gulf Coast 78597, United States
|011 (956) 761-8844
|Room Types


text:
Effect of Risk Factors on the Mechanism of Acute Thrombosis and Sudden Coronary Death in Women
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Background—Traditional risk factors have been linked to atherosclerotic heart disease in women. However, the effect of risk factors and menopausal status on the mechanism of sudden coronary death is unknown.
Methods and Results—We examined 51 cases of sudden coronary death and 15 hearts from women who died of trauma. Coronary deaths were divided into four mechanisms of death: ruptured plaque with acute thrombus (n=8), eroded plaque with acute thrombus (n=18), stable plaque with healed infarct (n=18), and stable plaque without infarction (n=7). Vulnerable plaques prone to rupture were defined as those with a thin, fibrous cap infiltrated by macrophages and were quantitated in coronary deaths and control subjects. Total cholesterol (TC), HDL cholesterol, glycosylated hemoglobin, cigarette smoking, and hypertension were determined in each case. Compared with control subjects, women with plaque ruptures had elevated TC (270±55 versus 194±44 mg/dL, P=0.002), and those with erosions were more likely to be smokers (78% versus 33%, P=0.01). Women with stable plaque and healed infarct had elevated glycosylated hemoglobin (10.2±5.0% versus 6.4±0.4% in control subjects, P=0.001) and were more likely to be hypertensive (50% versus 15% in control subjects, P=0.03). By multivariate analysis, cigarette smoking was associated with plaque erosion (P=0.03, odds ratio [OR] 21), glycoslyated hemoglobin with stable plaque and healed infarct (P=0.03, OR 41), TC with plaque rupture (P=0.02, OR 7), and hypertension with stable plaque with healed infarct (P=0.02, OR 15). Seven of 8 plaque ruptures occurred in women >50 years of age versus 3 of 18 erosions (P=0.001). In cases of coronary death, vulnerable plaques were associated with elevated cholesterol (P=0.002) and age >50 years (P=0.002), independent of other risk factors.
Conclusions—In women, traditional risk factors have distinct effects on the mechanisms of sudden coronary death, which vary by menopausal status. Effective risk factor modification may therefore differ between younger and older women and may be targeting different mechanisms of plaque instability.
Sudden cardiac death occurs in 300 000 people in the United States annually, >80% of which are due to coronary causes.1 Because it has been estimated that up to 50% of coronary deaths are sudden,1 2 pathologic observations about sudden coronary death are likely to reflect a fairly large proportion of patients who suffer from atherosclerotic coronary disease.
Although the incidence of sudden death is approximately four times greater in men than women,3 this difference decreases with advancing age.4 Estrogen has been implicated as a protective mechanism against the development of atherosclerosis. The effect of estrogen on the inhibition of atherosclerosis is poorly understood but may be related to lipoprotein metabolism5 or its effect on vascular smooth muscle.5 6 The protective effect of estrogen against atherosclerotic vascular disease is one of the major reasons to prescribe estrogen replacement treatment in postmenopausal women.7
Coronary risk factors have been well established in men and include cigarette smoking, dyslipidemia, diabetes mellitus, and hypertension.3 In women, hyperlipidemia (elevated total cholesterol [TC], low HDL-C, and hypertriglyceridemia), cigarette smoking, and diabetes mellitus have been linked to coronary artery disease, sudden death, and myocardial infarction.2 8 9 10 11 12 13 We have recently shown that in men, cigarette smoking is associated with coronary thrombosis and dyslipidemia with plaque rupture.14 It is unknown whether similar associations exist for women, especially given the likely effects of estrogen on the morphology of atherosclerosis.
The purpose of this study was to determine whether risk factors affect the mechanism of coronary death in women (specifically the plaque morphology underlying thrombosis and incidence of healed infarcts) and whether these mechanisms are modified by age >50 years or <50 years (a likely reflection of menopausal status). The results of this study should aid in targeting coronary risk factor modification and therapy in women with coronary artery disease.
Case Selection
Female victims of sudden death were identified at the Office of the Chief Medical Examiner of the State of Maryland. When an autopsy was performed, the heart was examined in consultation with the Department of Cardiovascular Pathology at the Armed Forces Institute of Pathology. These cases were evaluated prospectively in a similar manner during the same time period as previously reported in men.14 Fifteen control subjects who died of trauma were collected during the same study period. The trauma cases were chosen only if the age of the victim fell within the approximate study range (that is, >35 years of age). Risk factors (with the exception of age) were not known before inclusion into the study in any case.
Heart Study and Determination of Death Category
All hearts were studied under supervision of the medical examiner as previously described.14 Ten cases were published previously without risk factor data other than hypertension.15 Briefly, hearts were perfusion fixed in buffered formalin, and epicardial arteries were serially sectioned at 2- to 3-mm intervals. Each segment with >50% cross-sectional area luminal narrowing (estimated at gross examination) was submitted for histology, including Movat pentachrome stains. Coronary deaths were defined as natural deaths without extracardiac cause of death and in which ≥1 epicardial coronary arteries had >75% cross-sectional area lumen narrowed by atherosclerotic plaque or plaque with superimposed thrombus. Mean cross-sectional luminal area narrowing was determined by computerized morphometry of maximal narrowing of any epicardial artery and plaque underlying acute thrombus (Figure⇓).
Because deaths referred to the medical examiner are unexpected, all coronary deaths were classified as sudden as previously defined.14 16 Sudden death was defined as symptoms commencing within 6 hours of death (witnessed arrest) or death that occurred within 24 hours of the time that the victim was last seen alive in his normal state of health. Coronary deaths with acute thrombus were further categorized as plaque rupture if serial sectioning showed a connection between the thrombus and the necrotic core.
Vulnerable plaques were defined as a fibrous cap thinner than 65 μm infiltrated by macrophages overlying a necrotic core as previously defined.14 In each heart, the mean number of vulnerable plaques was tabulated by counting the number of segments with >50% luminal narrowing with histologic features of vulnerable plaque. In coronary deaths without acute thrombus, the category of death was assigned as stable plaque with healed myocardial infarct and stable plaque without healed infarct.14
Definition of Plaque Erosion
Plaque erosions were defined as an acute thrombus without features of plaque rupture. They consisted of an acute thrombus in direct contact with intimal plaque rich in smooth muscle cells with surrounding proteoglycan matrix. Necrotic core was either absent or poorly defined and when present was not in close proximity to the luminal thrombus.
Determination of Risk Factors and Menopausal Status
The postmortem serum evaluation of TC, HDL-C, and thiocyanate was performed as previously described.14 17 18 A thiocyanate level of ≥90 mg/dL was considered evidence for cigarette smoking.17 18 The evaluation of glycosylated hemoglobin on red blood cells and the evaluation of hypertension with renal morphometric vascular analysis have also been reported.14 Cases were discarded if there was gross hemolysis or if evaluation of total protein and serum albumin indicated hemoconcentration or hemodilution. The body mass index was estimated with the formula body weight/body height2 (kg/m2).
Investigators at the scene of death recorded all medications including estrogens, and autopsy and scene investigation resulted in knowledge of previous oophorectomy, if any. Dates of last menstrual periods were not known. An age of 50 years was considered an approximation for onset of menopause. The gross appearance and presence of the uterus and ovaries were evaluated in each case.
Statistical Analysis
Five categories of sudden death were considered, four coronary and one noncoronary: (1) acute plaque rupture, (2) acute plaque erosion, (3) stable plaque and healed infarct, (4) stable plaque and no healed infarct, and (5) trauma deaths. For univariate analysis, continuous variables (TC, HDL-C, glycosylated hemoglobin, and age) were compared among these five groups by comparisons of means (ANOVA means table). Categorical variables (smoking status, presumed menopausal status, [age >50 years], hypertension) were compared among these five groups by contingency tables and χ2 analysis. For multivariate analysis, logistic regression was performed four times separately to compare the control group with each of the four coronary death groups by using age and risk factors as independent variables (dependent variable=coronary versus control death). TC, HDL-C, and percent glycosylated hemoglobin were treated as continuous variables for determination of P values; for determination of odds ratios, a level of 210 mg/dL was used as a normal limit for cholesterol, 45 mg/dL for a normal limit for HDL-C, and 10% as an upper limit for the determination of diabetes mellitus.14 To test the association between vulnerable plaques and risk factors, only coronary deaths were studied. For univariate analysis, simple regression was used to test for an association between numbers of vulnerable plaques and continuous risk factor data in the four coronary groups. For categorical variables, mean numbers of vulnerable plaques in each heart were compared by Student's t test. ANOVA was used to test the association between the independent risk factor variables on the number of vulnerable plaques in each heart. Age >50 years was considered a categorical variable as an indicator of menopausal status.
General Clinical and Pathologic Data: Coronary Deaths
For sudden unexpected deaths, a total of 105 cases were initially collected. Seven were eliminated because of incomplete risk factor data based on hemolysis, hemodilution, or inadequate cells for the determination of glycohemoglobin. Of the 98 cases with serologic and blood data, the type of sudden death was determined after full autopsy and serial coronary artery evaluation. Forty-seven cases were excluded on the basis of lack of severe coronary disease (<75% maximal cross-sectional luminal narrowing in the absence of coronary thrombosis), resulting in 51 coronary deaths. In addition, 15 cases of traumatic death were studied in an identical fashion.
Of the 51 coronary deaths, 21 occurred in women >50 years of age and 30 in women ≤50 years of age. Acute thrombus overlying plaque erosion was present in 18 hearts (35%), acute thrombus overlying plaque rupture in 8 (16%), stable plaque with healed myocardial infarct in 18 (35%), and stable plaque without infarct in 7 (14%). The mean number of segments studied (those with >50% cross-sectional luminal narrowing) were 7±5 in cases of plaque erosion, 10±4 in cases of plaque rupture, 12±8 in cases of stable plaque with healed infarct, and 7±4 in cases of stable plaque without healed infarct. The number of segments with >50% cross-sectional luminal narrowing was 12±11 in women >50 years of age and 7±4 in women younger than <50 years of age (P=0.05). The number of severely narrowed segments (>75% cross-sectional luminal narrowing) was 2.7±1.7 in cases of plaque erosion, 4.0±1.1 in cases of plaque rupture, 4.2±1.3 in cases of stable plaque with healed infarct, and 3.1±2.0 in cases of stable plaque without healed infarct. Severely narrowed segments were significantly fewer in cases of plaque erosion compared with plaque rupture (P=0.05) and stable plaque with healed infarct (P=0.004). The total number of coronary histologic sections examined was 28±13 in cases of acute plaque rupture, 25±14 in cases of plaque erosion, 25±13 in cases of stable plaque with healed infarct, and 14±5 in cases of stable plaque without healed infarct.
Thirty-six (71%) of coronary deaths were witnessed (11 of 18 plaque erosions, 7 of 8 plaque ruptures, 11 of 18 stable plaques with healed infarcts, and 7 of 7 stable plaques without healed infarcts). Of the 36 witnessed coronary deaths, 8 (22%) women had chest pain, 12 (33%) complained of symptoms other than chest pain immediately before death, and 16 (45%) did not complained of symptoms. There was no correlation between category of death and presence of chest pain. Symptoms in women who did not complain of chest pain included back pain (2), dizziness (3), nausea and vomiting (1), fever and chills (1), stomach distention (1), left shoulder tingling (1), shortness of breath (1), malaise (1), and fatigue (1). None of the witnessed deaths occurred during exertion. A history of "heart disease" was present in 9 women with sudden coronary death (7 of 18 with stable plaque and healed infarcts, 1 of 8 with plaque rupture, and 1 of 8 with stable plaque without healed infarct), 2 of whom had a documented history of previous myocardial infarction (both with healed infarcts at autopsy). Other medical conditions included known hypertension (11), breast carcinoma (1), carotid endarterectomy (1), depression (3), emphysema (1), known hypercholesterolemia (1), insulin-dependent diabetes mellitus (5), asthma (1), alcoholism (2), glomerulonephritis (1), seizure disorder (1), schizophrenia (1), mitral valve prolapse (1), and lupus erythematosus (1). Fifteen women were receiving oral medications; one was receiving estrogen replacement therapy and 5 were receiving insulin for diabetes mellitus. Oral medications included amitriptyline, aminophylline, atenolol, sertraline, clonidine, furosemide, enalapril, alprazolam, coumadin, dilantin, metoprolol, hydrochlorothiazide, chlorpromazine, amlodipine, methyldopa, hydrochlorothiazide, sulfazoxazole, ranitidine, prednisone, and diltiazem. The patient receiving estrogen replacement was a 46-year-old woman (status post-hysterectomy/oophorectomy) with an eroded plaque. Other surgeries included mastectomy (1), hysterectomy without oophorectomy (1), and cholecystectomy and tubal ligation (4).
The mean heart weight in hearts with plaque rupture (483±108 g) and stable plaque with healed myocardial infarct (460±105) exceeded that of hearts with plaque erosion (372±87 g) (P=0.01). The mean heart weight in 7 hearts with stable plaque and no myocardial infarct was 375±128 g.
General Clinical and Pathologic Data: Noncoronary Deaths
The 15 trauma cases were 50±19 years of age, with a heart weight of 384±86 g. The mean heart weight of trauma deaths was significantly less than that of hearts with plaque rupture (P=0.02) and stable plaque with healed infarct (P=0.02). The maximum percent coronary stenosis for the trauma deaths was 13±16%.
Risk Factors and Mechanism of Death
In the 66 women, there were no significant differences between TC in women <50 years of age (194±63 mg/dL) versus women >50 years of age (221±61 mg/dL, P=0.11). HDL cholesterol was similar in both groups (47±18 versus 42±24 mg/dL, respectively, P=0.4), as was the frequency of presumed cigarette smoking (50% versus 58%, respectively). Percent glycohemoglobin was lower in young women (7.1±2.4% versus 9.3±5.6%, respectively, P=0.04), as was the frequency of hypertension (20% versus 48%, P=0.03). Body mass index was similar in young and older women (29±8.3 kg/m2 versus 28±7 kg/m2, respsectively, P=0.4). The mean heart weight was greater in women >50 years of age (454±124 g) than in women ≥50 years of age (385±84 g, P=0.009).
For each of the four categories of coronary deaths, mean age, TC, HDL-C, body mass index, and percent glycosylated hemoglobin are presented in Table 1⇓. Women with plaque rupture were significantly older than women with eroded plaque and stable plaque without myocardial infarct, and women with plaque erosion were significantly younger than those with stable plaque and healed infarct. The TC levels of women with plaque rupture were significantly elevated compared with women with stable plaque and women with plaque erosion. HDL-C and TC/HDL did not significantly differ among the groups. Body mass index was significantly greater in plaque rupture compared with plaque erosion. Percent glycohemoglobin was significantly higher in stable plaque with healed infarct compared with eroded plaque. Heart weight was less in hearts with acute erosion compared with hearts with stable plaque and healed infarct and hearts with acute rupture. When taken in relation to body mass index, the heart weight was greatest in women with stable plaque and healed infarct.
Compared with control subjects, women with acute ruptures had higher total cholesterol levels and higher heart weights (Table 2⇓). TC/HDL-C was significantly higher in women with stable plaque and healed infarct than in control subjects. Women with plaque erosion were more likely to be smokers than were control subjects (Table 2⇓). Women with stable plaque and healed infarct were more likely to be hypertensive and had elevated glycoslyated hemoglobin (Table 2⇓). By multivariate analysis, these associations were independent of other risk factors (Table 3⇓). Compared with control subjects, the odds ratio of elevated TC >210 mg/dL was 7 in women with plaque rupture, and the odds ratio of smoking in women with erosion was 21 compared with control subjects. The odds ratio of hypertension was 15, and the odds ratio of elevated glycosylated hemoglobin >10% was 41 in women with stable plaque and healed myocardial infarct versus control subjects. There were no significant associations between risk factors and stable plaque without healed infarct.
Incidence of Infarcts and Degree of Coronary Narrowing: Coronary Deaths
Acute myocardial infarcts were present in 8 of 18 plaque erosions, 2 of 8 plaque ruptures, 2 of 18 stable plaques with healed infarcts, and none of 7 stable plaques without healed infarcts. The maximal percent coronary artery stenosis in any artery (not necessarily that with thrombus) was 88±10% for stable plaque with healed infarct, 81±11% for plaque rupture, 81±6% for stable plaque without healed infarct, and 73±17% for eroded plaque. The maximal percent coronary artery stenosis was 84±10% in coronary deaths of women >50 years of age and 78±16% in women ≥50 years of age (P>0.1).
The 26 acute thrombi were located in proximal segments in 16 hearts (62%): proximal left anterior descending before first diagonal (10), proximal right before the first large branch or acute angle (5), and proximal circumflex before the obtuse marginal (1). Eight thrombi were in the mid portion of the left anterior descending (5) or right coronary (3); one thrombus was in the distal right. At the site of thrombus, the percent stenosis was 66±15% in women ≥50 years of age and 79±7% in women >50 years of age (P=0.02) and was 77±8% for plaque ruptures and 70±16% for plaque erosions (P>0.1). Thirteen (50%) of the thrombi were occlusive; 8 (80%) of those in women > 50 years of age and 5 (19%) of those in women <50 years of age were occlusive (P=0.04). Six of 18 (33%) of eroded versus 7 of 8 (88%) of plaque ruptures were occlusive (P=0.02).
Vulnerable Plaques and Risk Factors
The mean numbers of vulnerable plaques were associated with TC (r2=0.3, P=0.002), increasing age (r2=0.3, P=0.002), and increased glycohemoglobin (r2=0.2, P=0.05) by univariate analysis. When risk factors of hypercholesterolemia (TC >210 and TC/HDL-C >5), diabetes (glycohemoglobin >10), and age (>50 years) were considered as categorical variables, vulnerable plaques were more numerous in hearts from patients with increased age (P<0.0001) and abnormal TC and TC/HDL-C (Table 4⇓). By multivariate analysis, age >50 years and cholesterol were independently associated with numbers of vulnerable plaques (F=10.34, P=0.002; F=12.36, P=0.007, respectively). When age was used as a continuous variable, its association with mean numbers of vulnerable plaques was weaker (F=4.4, P=0.04). Other risk factor variables were not associated with vulnerable plaques (P>0.15 for all).
Current Study
This study demonstrates that in women who die suddenly with severe coronary disease, traditional risk factors and menopausal status affect the mechanism of sudden death and coronary artery thrombosis found at autopsy. Because the majority of acute coronary thrombi caused by plaque erosion occur in young female smokers without significantly elevated cholesterol levels, body mass index, or glycohemoglobin levels, it appears that smoking cessation is the most important risk factor modification indicated for this group. In older women who are hypercholesterolemic, plaque rupture plays an important role in the development of acute coronary thrombosis, underscoring the need for cholesterol reduction in women who are postmenopausal. Plaques vulnerable to rupture were far fewer in younger women who died of severe coronary artery atherosclerosis than in postmenopausal women, indicating that the development of the substrate for plaque rupture appears to be inhibited in premenopausal women.
Sudden coronary death in the setting of healed myocardial infarction without acute coronary thrombosis constituted 35% of coronary deaths in this study. Therefore, a reduction in sudden coronary deaths in women would need to target that group of patients as well. Similar to women with plaque rupture, they are likely to be significantly older than women with plaque erosion. In addition, these women were more likely to be diabetic or hypertensive, two risk factors more prevalent in older women in our study. Therefore, control of hypertension and blood glucose levels may reduce sudden deaths in women with known coronary disease and a history of ischemic heart disease.
In addition to establishing a correlation between risk factors and mechanism of sudden coronary death in women, this study also demonstrates age-related differences in percent luminal stenosis at the site of thrombus and extent of coronary disease. In younger women who died of severe coronary disease, the mean degree of narrowing by atherosclerotic plaque at the site of thrombus was only 66% cross-sectional area luminal narrowing (equivalent to 43% diameter luminal narrowing), and there were relatively few narrowed segments of coronary arteries compared with women >50 years of age. The implication of this finding is that angiography in younger women may underestimate potentially lethal coronary artery narrowings in younger women.
Although this study demonstrates a clear association between traditional risk factors and type of coronary plaque morphology in women who die suddenly, not all women showed these associations. Seven (14%) died of stable plaque without infarct; this group showed no association with known risk factors. Furthermore, not all women with erosions were smokers and not all women with healed infarcts and stable plaque had evidence of either hypertension or diabetes. Therefore, it appears that other nontraditional risk factors for atherosclerosis may independently affect plaque morphology or interact with traditional risk factors. There is an evolving list of newer risk factors that have been implicated in coronary atherosclerosis, including clotting factors such as plasminogen activator inhibitor, fibrinogen, von Willebrand factor antigen, and platelet glycoprotein IIb/IIIa gene polymorphism and lipid variants such as apolipoprotein E polymorphism and lipoprotein(a). The possible association of these risk factors with coronary plaque morphology are unknown16 and have not been addressed in this study. Inflammation has been identified as a key component of plaque instability in both ruptures and erosions,19 suggesting that local inflammation may be a mediator of acute thrombus with various underlying stimuli. However, the degree of inflammation in plaque erosion, as assessed by numbers of macrophages and lymphocytes, is significantly fewer compared with plaque rupture at the site of thrombosis in our previous study.20
Sex Differences in Coronary Thrombosis
The current study demonstrates both similarities and differences between men and women in the relation of acute thrombosis and coronary risk factors. The link between hypercholesterolemia and plaque rupture appears to occur only in women who are postmenopausal; age does not appear to have an affect on this relation in men.14 In addition, in women TC is specifically associated with plaque rupture, whereas in men, elevated TC/HDL-C is a predictor of plaque rupture. Because of the apparent protective effect of estrogen on plaque rupture, erosions are more common in women than in men.20 Furthermore, there appears to be a stronger link between diabetes and hypertension and sudden death caused by stable plaque with healed myocardial infarction in women than in men, for reasons that have yet to be explored.
Mechanisms of Sudden Coronary Death in Women
This study does not address possible cellular mechanisms that explain the association between risk factors and plaque morphology. The link between plaque rupture and elevated cholesterol levels may be explained by increased numbers of lipid-rich macrophages infiltrating fibrous caps, resulting in plaques vulnerable to rupture. The fact that premenopausal women appear to be protected in part from the effects of hyperlipidemia on the formation of vulnerable plaques suggests that estrogen may interfere with the accumulating of foam cells in coronary plaques, a hypothesis that has been supported by studies on nonhuman primates that demonstrate an inhibitory effect of estrogen replacement therapy on the uptake and degradation of LDL by the artery wall.15 The mechanism of formation of eroded plaques is unknown but may be related to a propensity to thrombosis that is facilitated by components of cigarette smoke.20 The apparent increased susceptibility of the chronically ischemic myocardium (healed infarction) to the development of fatal arrhythmias in patients with hypertension and diabetes, as shown in this study, may reflect microvascular disease that occurs in patients with diabetes and hypertension.21 22 The mechanism of sudden death in women with stable plaques and healed infarcts probably is exacerbated by left ventricular hypertrophy because the hearts of women with stable plaques and healed infarcts were significantly heavier than other hearts in this study.
Plaque Calcification and Extent of Luminal Narrowing
Previous autopsy studies have demonstrated that coronary artery lesions in young women contain less calcium and dense fibrous tissue than those of men and older women.23 24 The degree of calcification in ruptured plaques, which in the current study were found predominantly in older women, has been demonstrated to exceed that of eroded plaques, which are more common in younger women.20 Erosions also occur over plaques that result in a lesser degree of luminal narrowing, and this study demonstrated that the degree of arterial narrowing at the site of acute thrombus is less in young women than in older women. These data suggest that symptomatic coronary disease in young women may be angiographically less detectable, more likely to be missed on clinical evaluation, and more likely to be overlooked by ultrafast computed tomography.
Limitations of the Study
The major limitation of this study is the inherent selection bias caused by autopsy sampling. It is noteworthy that larger numbers of sudden coronary death were seen in women <50 years of age, which is contrary to epidemiologic studies of sudden death in men as well as women. The most likely explanation for the large proportion of deaths in younger women is a higher autopsy rate of unexpected death in younger women without a history of heart disease. Deaths are investigated with complete autopsy at the medical examiner's office if there is no medical explanation of sudden death, which is more likely to occur in younger women without a prior history. However, this apparent bias is unlikely to effect the observation that in younger women, plaque rupture and vulnerable plaques are uncommon findings. These data support the hypothesis that the premenopausal state is protective against plaque rupture as a mechanism of acute coronary events.
The mechanisms of sudden coronary death appear to differ in older women compared with younger women, and risk factors play different roles in these groups of patients. Young women who die of coronary artery thrombosis are often smokers with plaque erosions with relatively little coronary narrowing, whereas older women who die of coronary artery thrombosis are often hypercholesterolemic and have plaque ruptures with relatively severe coronary narrowing. The mechanism of sudden coronary death in hypertensive women and women with diabetes mellitus is often associated with healed myocardial infarcts and cardiomegaly. These data suggest that risk factor modification may be tailored to specific groups of women for the optimal reduction of sudden coronary death.
The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of the Army, the Department of the Air Force, or the Department of Defense.
- Received October 6, 1997.
- Revision received December 29, 1997.
- Accepted January 30, 1998.
- Copyright © 1998 by American Heart Association
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- Effect of Risk Factors on the Mechanism of Acute Thrombosis and Sudden Coronary Death in WomenAllen P. Burke, Andrew Farb, Gray T. Malcom, You-hui Liang, John Smialek and Renu VirmaniCirculation. 1998;97:2110-2116, originally published June 2, 1998http://dx.doi.org/10.1161/01.CIR.97.21.2110
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- Effect of Risk Factors on the Mechanism of Acute Thrombosis and Sudden Coronary Death in WomenAllen P. Burke, Andrew Farb, Gray T. Malcom, You-hui Liang, John Smialek and Renu VirmaniCirculation. 1998;97:2110-2116, originally published June 2, 1998http://dx.doi.org/10.1161/01.CIR.97.21.2110
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text:
List all words starting with acaricides
Only the word acaricides was found, nothing longer.
Some random words: wo ors hi dots faience efs elhi
This is not a dictionary, it's a word game wordfinder.
- Help and FAQ - Examples - Home
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text:
Blinded by the Sun
Saudi Arabian Sheikh, On the Eastern Road, You are the Sunlight, Psalm of the Spheres, The Drivers, Scarlet,
Scythes IV
Night of Years, Black Doves, I Can See Venus, Hello Jonah, Saleh, Apparition, Ho Chi Minh City, This Corpse is Dancing, Mt. Kilimanjaro, Helium, Blinded by the Sun, Butterfly
Sibylline Heliotricity
Estrella, The Ballerina, Cup of Sun, Tides Part I, Tides Part II, The Solar Rowboat, Quiet Sleeps the Bison, Bullet Proof Vest
A Collection of Beatles and Spiders
Bathe, Where Fish Learn to Fly and Birds Learn to Swim, Daedalus, song for the most beautiful susan, travelling song, logic, Mother I, A Collection of Beetles and Spiders, Been Driving for a Few Days Now
NEW! DANIEL SHAMS | POEMS AND POETRY <--- click this
To read excerpts from his debut book of poetry and prose "CHAOS, THE CLOUDS, AND THE TONGUE".
And next, for your sniffing, snooping poetic enjoyment we here at h-e-l-i-o-3-ciudades-dot-you-no-whut bring two u...(drum roll)...
Tiny Bloom - by the above aforementioned Poet(aster)
What curious choreography whirls in your tiny architecture, what strange perfume
That perplexes each nostril that intoxicates my interior with an unusual blaze!
It is amazing tiny bloom how much room we have for exhilaration, for joy
How I wish! How I want! How I lie! In this immense valley of your effusion
It is on great wings somehow that I've arrived before you so many times reborn,
Torn from heights forlorn, from nights endless, nights irremediable and yet again born
into doubts, into droughts of elation, and again airborn on said feathers
completely untethered, catapulted into bouts seasonal, bouts spontaneous
of unmitigated animal jubilation all woes momentarily overtaking
It is that you are here so simply and fully reachable and real
You've fallen like yet another feather to this field
So lovely, so light, so alluring! so imbued with might of unknown origin
To overpower me
You are no poppy, no prison, no oily stinging nettle, no briar prickling with thistle
You so unbound within the suprise of each unfolding morning
Continually unravelling, engaging with each and every advance of wing, foot and feather
The bees too have found you! The Cicadas too sing of your mystery and your youth!
What precious pollen hold you in that immaculate evolution
What savory seduction, what pheremones never before known you have!
What persuasive power emanates from your tiny frame tiny bloom!
Tell me! Teach me! Unleash me into your radiance!
Believe in me! To be born from this enchanting instant
And thrust into your entirety, that tireless infinity
Let me be of and beyond those tremulous borders of you!
Not All Grapes Go To Wine- by D.Sha(ms)
"cuyo diente
no perdonó a racimo, aun en la frente
de Baco..."
Luis de Góngora
Not all grapes smashed go to wine,
not so easily themselves do they find
In elegant nasal gardens with cigar and caviar hue entwined
No, not all grapes smashed go to wine,
some remain simply to imbue already purple toes
with a shade rosier hue
and never to cosy guts ever go
In fact some when smashed herald little juice
would hardly infuse the slightest rosy warmth bacchanalian
Some are grown in spoiled soil and so being
feel that they and they alone are somehow above toil
others by the moleish virtue of some peculiar flaw
having taken corruption from its aggressive constituents
are deemed refuse at birth, unfit for lawful use
banished from potential realms of mythological mirth
and doomed to dead dreams of gilded goblets and regal nosehairs
Others stubborn and unpatriotic refuse to employ their superdoted
(and consequently overdoted upon) graces
in favor of the country, region or vineyard
in which they were deployed
and squish not under foot
Others splash exceedingly when smashed
and mix badly with virile elements agile
Some are smashed on the vine, born wine you could say
inseparable from the leaves in which they are twined
From the soil and sun from which their nutrients sprung
Indeed great grapes spread a truly luxurious divan
So much so as to incite certain seeking souls
not only to abandon the suicide alternative
but in spite of themselves upon experiencing them to exlaim
"Tarry yet, though art so fair!" to the fleeting glorious moment...
Others break bottle after bottle seeking a solution
in which their hue could hide
Some grapes were made only to paint a blackbirds beak
Others smashed were simply weak
Because grapes great make slaves of your feet
then make slaves of even the most distinguished elite
Extinguishing the feeble fires
underneath any lengthy treaty on practical reason
Which is to say they just might flourish in your gypsy brain
like nights endless going to weeks that culminate in years
Grapes great seek great oceans to taint
Great rich bellies to paint
Aspire to launch their aromas and lounge
in lush and reknowned international gardens
Said aromas can be found socializing
in sophisticated French nosehairs,
Can be found exercising their uncanny art
in dense cigar thick capitalistic lairs
atop even the quivering weaves of vintage 1960s Italian orange and olive green mohair cardigan sweaters
bedecking recklessly the amorous night bedroom floor of a decadent Parisienne flat
Great grapes make to dance the atoms of a fine woman's brain
make bloom the tinkering thinkers subterranean refrain
into an unexpected romance
Great grapes make the dead to dance
to spring from the gap in the connoiseurs teeth
unsheathing their ancient saavy swords to spar
as far as in defunct russian tzars olfactory gardens
Let them slay! You would say just to see them,
Let them play! You would say, just to see them Let them play, newlywed upon old Bacchus' brow
That's what great grapes do!
But not all great grapes go to wine, its said
some sleep endless on an invisible vine
basking in the warmth divine of an eternal sun
never to be found by anyone!
And contrary to popular belief,
not all great grapes ought to be tasted
need not be wasted on pretentious whims or rich fools' lips
which is to say some grapes are inimitable treasures,
not passing pleasures
Great grapes light subaquatic monkey fires in a neanderthal brain
make to suddenly rain smoldering phoenix feathers
in an isolated artic circle expanse
Great grapes speak in leagues paint Hermes boots
Paint a deep blue midnight a savory purple
Seed an elegant pageant upon a mute mutt tongue
Breed a broad banquet of astros
upon diligent buds unsuspecting
Great grapes smash again and again
upon the remote recesses of ones brain
bearing new gypsy frontiers
Savage yet refined,
resurrecting ancient olfactory sensation
impossible to define
mined explicitly from the uncanny sap
of Bacchus' legendary and lost noble brow.
"There are as many paths to god as there are souls in this universe..."
Sufi quote


text:
Outdoor Pools in Valdeprado Soria > Castille and León > Spain
Are you on holiday and desire to keep fit and healthy? Swimia.com gives you the painless and quickest method to obtain pool near Valdeprado. Thanks to some new Outdoor Pools in Valdeprado submitted every day, Swimia.com is increasing day-to-day the number of stored pools. Please do not hesitate to get in touch with us if you obtain any inaccurate or incomplete information.
There are normally discounts on the market to senior citizen and little children. Find out by contacting your nearest pool in Valdeprado. Please check the nearest Outdoor Pools in Valdeprado or Contact us to ADD IT. It's cost-free!
Nearest Outdoor Pools in Valdeprado, listed 4
Estadio Hispánico
Updated on 2016 Calle Gil de Villasinta s/n , Leon , Spain (Postal Code: 24005). Swimmers like you have reported 25 meters, 6 lanes, Indoors. Also, you will find 25 meters, 6 lanes, Indoor/Outdoor. Just in case you need to make contact with this Pool prior to dropping by, we only know the phone number.
Centro Deportivo José Luis Talamillo. Supera
Updated on 2016 C/ Victoria Balfé s/n 09006, Burgos..
Centro de Deporte y Ocio-Municipal Almendrera
Updated on 2016 C. Almendrera s/n , Arroyo de la Encomienda (La Flecha) , Spain (Postal Code: 47195). Swimmers like you have reported 25 meters, 6 lanes, Indoors, Outdoors. Also, you will find 25 meters, 6 lanes. Just in case you desire to contact this Pool prior to dropping by, we only know the phone number.
Piscina Climatizada La Lastrilla
Calle de Los Escobares, s.n , La Lastrilla , Spain (Postal Code: 40196). This sports center offers 25 meters, 6 lanes, Indoor/Outdoor. Contact knowledge for this Pool for example phone number and email address are number.


text:
Lyrics Depot is your source of lyrics to Heartland by U2. Please check back for more U2 lyrics.
Heartland Lyrics
Artist: U2
Album: Rattle & Hum
See the sun rise over her skin
Don't change it
See the sun rise over her skin
Dawn changes everything
And the delta sun
Burns bright and violet
Mississippi and the cotton wool heat
Sixty-six a highway speaks
Of deserts dry
Of cool green valleys
Gold and silver veins
Of the shining cities
In this heartland
In this heartland soil
In this heartland
Heaven knows this is a heartland
See the sun rise over her skin
She feels like water in my hand
Freeway like a river cuts through this land
Into the side of love
Like a burning spear
And the poison rain
Brings a flood of fear
Through the ghost-ranch hills
Death valley waters
In the towers of steel
Belief goes on and on
In this heartland
In this heartland soil
In this heartland
Heaven knows this is a heartland
Heartland...heaven knows this is a heartland
Heartland...heaven's day here in the heartland
U2 Lyrics
U2 Rattle & Hum Lyrics
More U2 Music Lyrics:
U2 - Always Lyrics
U2 - Everlasting Love Lyrics
U2 - Lemon Lyrics
U2 - Peace On Earth Lyrics
U2 - Stay (Faraway, So Close!) Lyrics
U2 - The Sweetest Thing Lyrics
U2 - With or Without You Lyrics
U2 - Your Blue Room Lyrics


text:
Hotels near Royal Botanic Gardens
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Hotels within 0.5 miles of Royal Botanic Gardens
- Most bookedRoyce Hotel
178 people looked at this hotel in the last hour
Most recent review
"We stayed at the Royce for our 10th Wedding Aniversary and we were really happy with everything. We had dinner at the Dish downstairs and both really enjoyed our meals. Took advantage of our complimentary drinks at the Amberlounge. Breakfast live up to all our expectations. Would highly recommend..."
A Traveller, Oct 2016, AU
141 people looked at this hotel in the last hour
Most recent review
"Will stay here again as convenient to transport and also walking distance to parks and function centres and on street parking"
A Traveller, Oct 2016, US
37 people looked at this hotel in the last hour
Most recent review
"Exceptionally helpful staff, great attitude and knowledgeable about transport options. Location quiet yet easy walk to Art Gallery, Botanical Gardens and Southbank. Roomy apartment with good office facilities. Excellent night time views of city lights. I will certainly stay there again quite soon."
A Traveller, Oct 2016, AU
20 people looked at this hotel in the last hour
Most recent review
"One of the most secure places that we have ever been in Views were great, staff was very helpful, ideal location central to most things that we wanted to see"
A Traveller, Oct 2016, AU
15 people looked at this hotel in the last hour
Most recent review
"Strongly recommend this apartment!!! The location is great!!! Only a few stops (tram) to Flinders Street. Very short walking distance to take the tram. 3min. Convenient! The apartment is clean and new. The facility is excellent. Heater, washer and dryer provided. Kitchenware is complete. The envi..."
A Traveller, Oct 2016, AU
- Corporate Keys - ElmNo Guest Reviews yet
8 people looked at this hotel in the last hour
7 people looked at this hotel in the last hour
Most recent review
"It was a great spot. For an overnight stay, it was very convenient for us as it was close to cafes/restaurants where we could get dinner and then breakfast quickly. "
m, Sep 2016, AU
7 people looked at this hotel in the last hour
Most recent review
"Was just an overall Brilliant Family get away / adventure."
A Traveller, Apr 2016, AU
Hotels within 1 mile of Royal Botanic Gardens
61 people looked at this hotel in the last hour
Most recent review
"Was just an overnight stay before an early appointment, but was very nice to walk into an open clean and comfortable room! I am already thinking of staying here again while my husband is in hospital as everything felt safe and comfortable!!"
A Traveller, Oct 2016, AU
32 people looked at this hotel in the last hour
Most recent review
"one of the tiles fell in our bathroom! otherwise the rooms were clean and neat - not very luxurious but for the price and location they were decent. staff could have been friendlier, and exterior needs to be renovated to be more inviting."
A Traveller, Sep 2016, AU
Map of hotels near Royal Botanic Gardens
- Crown Casino and Entertainment Complex
- Melbourne Convention and Exhibition Centre
- Melbourne Cricket Ground (MCG)
- Collins Street
- Etihad Stadium
- Queen Victoria Market
- Royal Melbourne Showgrounds
- Albert Park
- Royal Melbourne Hospital
- Royal Children's Hospital
- Rod Laver Arena
- Federation Square
- Bourke Street Mall
- Southbank Promenade
- University of Melbourne
- Melbourne Central
- Deakin University
- AAMI Park
- Monash University
- Chapel Street
Hotels in Melbourne near Royal Botanic Gardens
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When you search for hotels near Royal Botanic Gardens with Hotels.com, you need to first check our online map and see the distance you will be from Royal Botanic Gardens, Victoria.
Our maps are based on hotel search and display areas and neighborhoods of each hotel so you can see how close you are from Royal Botanic Gardens and refine your search within Melbourne or Victoria based on closest public transportation, restaurants and entertainment so you can easily get around the city. All the hotels details page show an option for free or paid onsite parking.
If you wish to see the hotels with the highest featuring discounts and deals near Royal Botanic Gardens, simply filter by price/ average nightly rate. We recommend you filter by star rating and read our genuine guest reviews so you can get the best quality hotel with the best discount.
One of the new features on Hotels.com guest reviews is that also show reviews from Expedia for Royal Botanic Gardens hotels and the TripAdvisor Royal Botanic Gardens hotels reviews so you can make sure that you checking with a reliable source. See the review scores on our Melbourne hotel information pages.
Make the most out of your family vacation when you book your accommodation with Hotels.com – book your hotel near Royal Botanic Gardens, Melbourne after reviewing the facilities and amenities listed for each hotel.
After booking your hotel near Royal Botanic Gardens, expect to receive your reservation confirmation in the mail in less than 10 minutes. The confirmation email contains more information on all nearby attractions, local directions and weather forecast, so you can better plan the days during your trip.
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The best hotel deals are here: We have Royal Botanic Gardens hotel deals, Royal Botanic Gardens last minute deals and offers to get you the cheapest Royal Botanic Gardens hotel with our lowest price guarantee.
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