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On June 8, 9 and 10, selected teachers and educational assistants from SCDSB attended a PEERS training session held at Laurentian University. The training sessions were lead by Dr. Elizabeth Laugeson, assistant professor from UCLA. Read more...
Parents, Educators and Community Partners are invited to join us to hear Dr. Jean Clinton speak about 'Student Engagement and the Power of Relationships' on Wednesday, June 15th, 2016 at 6:30 p.m. at St. Charles College, 1940 Hawthorne Street. Read more...
On Friday, May 6, 2016, staff and students at St. Anne Catholic School reached what at first seemed like an impossible goal: they raised over $17,043.83 for cancer! A 'Relay for Life' campaign to raise funds for the disease was launched at the school for the third consecutive year. Read more...
A musical trio of students from St. Anne Catholic School had a lot of success at this year's Kiwanis Music Festival! The group won a Gold Award for their performance of The Pink Panther, and was invited to perform at the final Kiwanis concert featuring outstanding acts. Read more...
Celebrating or Remembering? Sympathy or Empathy? Fighting back? What motivates us to get involved in events such as the Cancer Society Relay for Life? Come out and see for yourself! Read more...
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Most Cited BBA Molecular Basis of Disease Articles
The most cited articles published since 2011, extracted from Scopus.
PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammationTamas Varga | Zsolt Czimmerer | Laszlo Nagy
Volume 1812, Issue 8, August 2011, Pages 1007-1022
Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were thought to serve as simple energy storing molecules. More recently it has been realized that they can also initiate and regulate signaling events that will decisively influence development, cellular differentiation, metabolism and related functions through the regulation of gene expression. Multicellular organisms dedicate a large family of nuclear receptors to these tasks. These proteins combine the defining features of both transcription factors and receptor molecules, and therefore have the unique ability of being able to bind lipid signaling molecules and transduce the appropriate signals derived from lipid environment to the level of gene expression. Intriguingly, the members of a subfamily of the nuclear receptors, the peroxisome proliferator-activated receptors (PPARs) are able to sense and interpret fatty acid signals derived from dietary lipids, pathogenic lipoproteins or essential fatty acid metabolites. Not surprisingly, Peroxisome proliferator-activated receptors were found to be key regulators of lipid and carbohydrate metabolism. Unexpectedly, later studies revealed that Peroxisome proliferator-activated receptors are also able to modulate inflammatory responses. Here we summarize our understanding on how these transcription factors/receptors connect lipid metabolism to inflammation and some of the novel regulatory mechanisms by which they contribute to homeostasis and certain pathological conditions. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease. © 2011 Elsevier B.V.
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevityVittorio Calabrese | Carolin Cornelius | Albena T. Dinkova-Kostova | Ivo Iavicoli | Rosanna Di Paola | Aleardo Koverech | Salvatore Cuzzocrea | Enrico Rizzarelli | Edward J. Calabrese
Volume 1822, Issue 5, May 2012, Pages 753-783
Modulation of endogenous cellular defense mechanisms represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. This paper introduces the emerging role of exogenous molecules in hormetic-based neuroprotection and the mitochondrial redox signaling concept of hormesis and its applications to the field of neuroprotection and longevity. Maintenance of optimal long-term health conditions is accomplished by a complex network of longevity assurance processes that are controlled by vitagenes, a group of genes involved in preserving cellular homeostasis during stressful conditions. Vitagenes encode for heat shock proteins (Hsp) Hsp32, Hsp70, the thioredoxin and the sirtuin protein systems. Dietary antioxidants, such as polyphenols and L-carnitine/acetyl-L-carnitine, have recently been demonstrated to be neuroprotective through the activation of hormetic pathways, including vitagenes. Hormesis provides the central underpinning of neuroprotective responses, providing a framework for explaining the common quantitative features of their dose response relationships, their mechanistic foundations, their relationship to the concept of biological plasticity as well as providing a key insight for improving the accuracy of the therapeutic dose of pharmaceutical agents within the highly heterogeneous human population. This paper describes in mechanistic detail how hormetic dose responses are mediated for endogenous cellular defense pathways including sirtuin, Nrfs and related pathways that integrate adaptive stress responses in the prevention of neurodegenerative diseases. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease. © 2011 Elsevier B.V.
Functions of plasmalogen lipids in health and diseaseNancy E. Braverman | Ann B. Moser
Volume 1822, Issue 9, September 2012, Pages 1442-1452
Plasmalogens are a unique class of membrane glycerophospholipids containing a fatty alcohol with a vinyl-ether bond at the sn-1 position, and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone. These two features provide novel properties to these compounds. Although plasmalogens represent up to 20% of the total phospholipid mass in humans their physiological roles have been challenging to identify, and are likely to be particular to different tissues, metabolic processes and developmental stages. Their biosynthesis starts in peroxisomes, and defects at these steps cause the malformation syndrome, Rhizomelic Chondrodysplasia Punctata (RCDP). The RCDP phenotype predicts developmental roles for plasmalogens in bone, brain, lens, lung, kidney and heart. Recent studies have revealed secondary plasmalogen deficiencies associated with more common disorders and allow us to tease out additional pathways dependent on plasmalogen functions. In this review, we present current knowledge of plasmalogen biology in health and disease. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of peroxisomes in Health and Disease. © 2012 Elsevier B.V..
Radical changes in multiple sclerosis pathogenesisJack Van Horssen | Maarten E. Witte | Gerty Schreibelt | Helga E. de Vries
Volume 1812, Issue 2, February 2011, Pages 141-150
Reactive oxygen species (ROS) contain one or more unpaired electrons and are formed as intermediates in a variety of normal biochemical reactions. However, when generated in excess amounts or not appropriately controlled, ROS initiate extensive cellular damage and tissue injury. ROS have been implicated in the progression of cancer, cardiovascular disease and neurodegenerative and neuroinflammatory disorders, such as multiple sclerosis (MS). In the last decade there has been a major interest in the involvement of ROS in MS pathogenesis and evidence is emerging that free radicals play a key role in various processes underlying MS pathology. To counteract ROS-mediated damage, the central nervous system is equipped with an intrinsic defense mechanism consisting of endogenous antioxidant enzymes. Here, we provide a comprehensive overview on the (sub)cellular origin of ROS during neuroinflammation as well as the detrimental effects of ROS in processing underlying MS lesion development and persistence. In addition, we will discuss clinical and experimental studies highlighting the therapeutic potential of antioxidant protection in the pathogenesis of MS. © 2010 Elsevier B.V.
α-Synuclein misfolding and Parkinson's diseaseLeonid Breydo | Jessica W. Wu | Vladimir N. Uversky
Volume 1822, Issue 2, February 2012, Pages 261-285
Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has been identified as the major component of Lewy bodies and Lewy neurites, the characteristic proteinaceous deposits that are the hallmarks of PD. α-Synuclein is a typical intrinsically disordered protein, but can adopt a number of different conformational states depending on conditions and cofactors. These include the helical membrane-bound form, a partially-folded state that is a key intermediate in aggregation and fibrillation, various oligomeric species, and fibrillar and amorphous aggregates. The molecular basis of PD appears to be tightly coupled to the aggregation of α-synuclein and the factors that affect its conformation. This review examines the different aggregation states of α-synuclein, the molecular mechanism of its aggregation, and the influence of environmental and genetic factors on this process. © 2011 Elsevier B.V.
Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signalingP. Palsamy | S. Subramanian
Volume 1812, Issue 7, July 2011, Pages 719-731
Hyperglycemia-mediated oxidative stress plays a crucial role in the progression of diabetic nephropathy. Hence, the present study was hypothesized to explore the renoprotective nature of resveratrol by assessing markers of oxidative stress, proinflammatory cytokines and antioxidant competence in streptozotocin-nicotinamide-induced diabetic rats. Oral administration of resveratrol to diabetic rats showed a significant normalization on the levels of creatinine clearance, plasma adiponectin, C-peptide and renal superoxide anion, hydroxyl radical, nitric oxide, TNF-α, IL-1β, IL-6 and NF-κB p65 subunit and activities of renal aspartate transaminase, alanine transaminase and alkaline phosphatase in comparison with diabetic rats. The altered activities of renal aldose reductase, sorbitol dehydrogenase and glyoxalase-I and elevated level of serum advanced glycation end products in diabetic rats were also reverted back to near normalcy. Further, resveratrol treatment revealed a significant improvement in superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase activities and vitamins C and E, and reduced glutathione levels, with a significant decline in lipid peroxides, hydroperoxides and protein carbonyls levels in diabetic kidneys. Similarly, mRNA and protein analyses substantiated that resveratrol treatment notably normalizes the renal expression of Nrf2/Keap1and its downstream regulatory proteins in the diabetic group of rats. Histological and ultrastructural observations also evidenced that resveratrol effectively protects the kidneys from hyperglycemia-mediated oxidative damage. These findings demonstrated the renoprotective nature of resveratrol by attenuating markers of oxidative stress in renal tissues of diabetic rats. © 2011 Elsevier B.V.
Mast cells and inflammationTheoharis C. Theoharides | Konstantinos Dionysios Alysandratos | Asimenia Angelidou | Danae Anastasia Delivanis | Nikolaos Sismanopoulos | Bodi Zhang | Shahrzad Asadi | Magdalini Vasiadi | Zuyi Weng | Alexandra Miniati | Dimitrios Kalogeromitros
Volume 1822, Issue 1, January 2012, Pages 21-33
Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their involvement in acquired and innate immunity. Increasing evidence now implicates mast cells in inflammatory diseases where they are activated by non-allergic triggers, such as neuropeptides and cytokines, often exerting synergistic effects as in the case of IL-33 and neurotensin. Mast cells can also release pro-inflammatory mediators selectively without degranulation. In particular, IL-1 induces selective release of IL-6, while corticotropin-releasing hormone secreted under stress induces the release of vascular endothelial growth factor. Many inflammatory diseases involve mast cells in cross-talk with T cells, such as atopic dermatitis, psoriasis and multiple sclerosis, which all worsen by stress. How mast cell differential responses are regulated is still unresolved. Preliminary evidence suggests that mitochondrial function and dynamics control mast cell degranulation, but not selective release. Recent findings also indicate that mast cells have immunomodulatory properties. Understanding selective release of mediators could explain how mast cells participate in numerous diverse biologic processes, and how they exert both immunostimulatory and immunosuppressive actions. Unraveling selective mast cell secretion could also help develop unique mast cell inhibitors with novel therapeutic applications. This article is part of a Special Issue entitled: Mast cells in inflammation. © 2010 Elsevier B.V.
Manganese superoxide dismutase, MnSOD and its mimicsSumitra Miriyala | Ivan Spasojevic | Artak Tovmasyan | Daniela Salvemini | Zeljko Vujaskovic | Daret St. Clair | Ines Batinic-Haberle
Volume 1822, Issue 5, May 2012, Pages 794-814
Increased understanding of the role of mitochondria under physiological and pathological conditions parallels increased exploration of synthetic and natural compounds able to mimic MnSOD - endogenous mitochondrial antioxidant defense essential for the existence of virtually all aerobic organisms from bacteria to humans. This review describes most successful mitochondrially-targeted redox-active compounds, Mn porphyrins and MitoQ 10 in detail, and briefly addresses several other compounds that are either catalysts of O 2- dismutation, or its non-catalytic scavengers, and that reportedly attenuate mitochondrial dysfunction. While not a true catalyst (SOD mimic) of O 2- dismutation, MitoQ 10 oxidizes O 2- to O 2 with a high rate constant. In vivo it is readily reduced to quinol, MitoQH 2, which in turn reduces ONOO - to NO 2, producing semiquinone radical that subsequently dismutes to MitoQ 10 and MitoQH 2, completing the "catalytic" cycle. In MitoQ 10, the redox-active unit was coupled via 10-carbon atom alkyl chain to monocationic triphenylphosphonium ion in order to reach the mitochondria. Mn porphyrin-based SOD mimics, however, were designed so that their multiple cationic charge and alkyl chains determine both their remarkable SOD potency and carry them into the mitochondria. Several animal efficacy studies such as skin carcinogenesis and UVB-mediated mtDNA damage, and subcellular distribution studies of Saccharomyces cerevisiae and mouse heart provided unambiguous evidence that Mn porphyrins mimic the site and action of MnSOD, which in turn contributes to their efficacy in numerous in vitro and in vivo models of oxidative stress. Within a class of Mn porphyrins, lipophilic analogs are particularly effective for treating central nervous system injuries where mitochondria play key role. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease. © 2011 Elsevier B.V.
Endothelial dysfunction - A major mediator of diabetic vascular diseaseCristina M. Sena | Ana M. Pereira | Raquel Seiça
Volume 1832, Issue 12, December 2013, Pages 2216-2231
The vascular endothelium is a multifunctional organ and is critically involved in modulating vascular tone and structure. Endothelial cells produce a wide range of factors that also regulate cellular adhesion, thromboresistance, smooth muscle cell proliferation, and vessel wall inflammation. Thus, endothelial function is important for the homeostasis of the body and its dysfunction is associated with several pathophysiological conditions, including atherosclerosis, hypertension and diabetes. Patients with diabetes invariably show an impairment of endothelium-dependent vasodilation. Therefore, understanding and treating endothelial dysfunction is a major focus in the prevention of vascular complications associated with all forms of diabetes mellitus. The mechanisms of endothelial dysfunction in diabetes may point to new management strategies for the prevention of cardiovascular disease in diabetes. This review will focus on the mechanisms and therapeutics that specifically target endothelial dysfunction in the context of a diabetic setting. Mechanisms including altered glucose metabolism, impaired insulin signaling, low-grade inflammatory state, and increased reactive oxygen species generation will be discussed. The importance of developing new pharmacological approaches that upregulate endothelium-derived nitric oxide synthesis and target key vascular ROS-producing enzymes will be highlighted and new strategies that might prove clinically relevant in preventing the development and/or retarding the progression of diabetes associated vascular complications. © 2013 Elsevier B.V.
MicroRNAs and the cell cycleMaría José Bueno | Marcos Malumbres
Volume 1812, Issue 5, May 2011, Pages 592-601
The control of cell proliferation by microRNAs (miRNAs) is well established and the alteration of these small, non-coding RNAs may contribute to tumor development by perturbing critical cell cycle regulators. Oncogenic miRNAs may facilitate cell cycle entry and progression by targeting CDK inhibitors or transcriptional repressors of the retinoblastoma family. On the other hand, tumor suppressor miRNAs induce cell cycle arrest by downregulating multiple components of the cell cycle machinery. Recent data also suggest that miRNAs act co-ordinately with transcriptional factors involved in cell cycle regulation such as c-MYC, E2F or p53. These miRNAs not only can potentiate the function of these factors but they may also limit the excessive translation of cell cycle proteins upon mitogenic or oncogenic stimuli to protect cells from replicative stress. The implications of these regulatory networks in cell proliferation and human disease are discussed. © 2011 Elsevier B.V.
Disruption of central nervous system barriers in multiple sclerosisJorge Ivan Alvarez | Romain Cayrol | Alexandre Prat
Volume 1812, Issue 2, February 2011, Pages 252-264
The delicate microenvironment of the central nervous system (CNS) is protected by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCB). These barriers function in distinct CNS compartments and their anatomical basis lay on the junctional proteins present in endothelial cells for the BBB and in the choroidal epithelium for the BCB. During neuroinflammatory conditions like multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE), activation or damage of the various cellular components of these barriers facilitate leukocyte infiltration leading to oligodendrocyte death, axonal damage, demyelination and lesion development. This manuscript will review in detail the features of these barriers under physiological and pathological conditions, particularly when focal immune activation promotes the loss of the BBB and BCB phenotype, the upregulation of cell adhesion molecules (CAMs) and the recruitment of immune cells. © 2010 Elsevier B.V.
Diffusion tensor imaging of cerebral white matter integrity in cognitive agingDavid J. Madden | Ilana J. Bennett | Agnieszka Burzynska | Guy G. Potter | Nan kuei Chen | Allen W. Song
Volume 1822, Issue 3, March 2012, Pages 386-400
In this article we review recent research on diffusion tensor imaging (DTI) of white matter (WM) integrity and the implications for age-related differences in cognition. Neurobiological mechanisms defined from DTI analyses suggest that a primary dimension of age-related decline in WM is a decline in the structural integrity of myelin, particularly in brain regions that myelinate later developmentally. Research integrating behavioral measures with DTI indicates that WM integrity supports the communication among cortical networks, particularly those involving executive function, perceptual speed, and memory (i.e., fluid cognition). In the absence of significant disease, age shares a substantial portion of the variance associated with the relation between WM integrity and fluid cognition. Current data are consistent with one model in which age-related decline in WM integrity contributes to a decreased efficiency of communication among networks for fluid cognitive abilities. Neurocognitive disorders for which older adults are at risk, such as depression, further modulate the relation between WM and cognition, in ways that are not as yet entirely clear. Developments in DTI technology are providing a new insight into both the neurobiological mechanisms of aging WM and the potential contribution of DTI to understanding functional measures of brain activity. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease. © 2011 Elsevier B.V.
Antioxidant therapies in traumatic brain and spinal cord injuryMona Bains | Edward D. Hall
Volume 1822, Issue 5, May 2012, Pages 675-684
Free radical formation and oxidative damage have been extensively investigated and validated as important contributors to the pathophysiology of acute central nervous system injury. The generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is an early event following injury occurring within minutes of mechanical impact. A key component in this event is peroxynitrite-induced lipid peroxidation. As discussed in this review, peroxynitrite formation and lipid peroxidation irreversibly damages neuronal membrane lipids and protein function, which results in subsequent disruptions in ion homeostasis, glutamate-mediated excitotoxicity, mitochondrial respiratory failure and microvascular damage. Antioxidant approaches include the inhibition and/or scavenging of superoxide, peroxynitrite, or carbonyl compounds, the inhibition of lipid peroxidation and the targeting of the endogenous antioxidant defense system. This review covers the preclinical and clinical literature supporting the role of ROS and RNS and their derived oxygen free radicals in the secondary injury response following acute traumatic brain injury (TBI) and spinal cord injury (SCI) and reviews the past and current trends in the development of antioxidant therapeutic strategies. Combinatorial treatment with the suggested mechanistically complementary antioxidants will also be discussed as a promising neuroprotective approach in TBI and SCI therapeutic research. This article is part of a Special Issue entitled: Antioxidants and antioxidant treatment in disease. © 2011 Elsevier B.V.
Role of peroxisomes in ROS/RNS-metabolism: Implications for human diseaseMarc Fransen | Marcus Nordgren | Bo Wang | Oksana Apanasets
Volume 1822, Issue 9, September 2012, Pages 1363-1373
Peroxisomes are cell organelles that play a central role in lipid metabolism. At the same time, these organelles generate reactive oxygen and nitrogen species as byproducts. Peroxisomes also possess intricate protective mechanisms to counteract oxidative stress and maintain redox balance. An imbalance between peroxisomal reactive oxygen species/reactive nitrogen species production and removal may possibly damage biomolecules, perturb cellular thiol levels, and deregulate cellular signaling pathways implicated in a variety of human diseases. Somewhat surprisingly, the potential role of peroxisomes in cellular redox metabolism has been underestimated for a long time. However, in recent years, peroxisomal reactive oxygen species/reactive nitrogen species metabolism and signaling have become the focus of a rapidly evolving and multidisciplinary research field with great prospects. This review is mainly devoted to discuss evidence supporting the notion that peroxisomal metabolism and oxidative stress are intimately interconnected and associated with age-related diseases. We focus on several key aspects of how peroxisomes contribute to cellular reactive oxygen species/reactive nitrogen species levels in mammalian cells and how these cells cope with peroxisome-derived oxidative stress. We also provide a brief overview of recent strategies that have been successfully employed to detect and modulate the peroxisomal redox status. Finally, we highlight some gaps in our knowledge and propose potential avenues for further research. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of peroxisomes in Health and Disease. © 2011 Elsevier B.V..
Oxidative stress and mitochondrial dysfunction in Alzheimer's diseaseXinglong Wang | Wenzhang Wang | Li Li | George Perry | Hyoung gon Lee | Xiongwei Zhu
Volume 1842, Issue 8, January 2014, Pages 1240-1247
Alzheimer's disease (AD) exhibits extensive oxidative stress throughout the body, being detected peripherally as well as associated with the vulnerable regions of the brain affected in disease. Abundant evidence not only demonstrates the full spectrum of oxidative damage to neuronal macromolecules, but also reveals the occurrence of oxidative events early in the course of the disease and prior to the formation of the pathology, which support an important role of oxidative stress in AD. As a disease of abnormal aging, AD demonstrates oxidative damage at levels that significantly surpass that of elderly controls, which suggests the involvement of additional factor(s). Structurally and functionally damaged mitochondria, which are more proficient at producing reactive oxygen species but less so in ATP, are also an early and prominent feature of the disease. Since mitochondria are also vulnerable to oxidative stress, it is likely that a vicious downward spiral involving the interactions between mitochondrial dysfunction and oxidative stress contributes to the initiation and/or amplification of reactive oxygen species that is critical to the pathogenesis of AD. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction and Neurodegenerative Diseases. © 2013 Elsevier B.V.
The blood-brain barrier, chemokines and multiple sclerosisDavid W. Holman | Robyn S. Klein | Richard M. Ransohoff
Volume 1812, Issue 2, February 2011, Pages 220-230
The infiltration of leukocytes into the central nervous system (CNS) is an essential step in the neuropathogenesis of multiple sclerosis (MS). Leukocyte extravasation from the bloodstream is a multistep process that depends on several factors including fluid dynamics within the vasculature and molecular interactions between circulating leukocytes and the vascular endothelium. An important step in this cascade is the presence of chemokines on the vascular endothelial cell surface. Chemokines displayed along the endothelial lumen bind chemokine receptors on circulating leukocytes, initiating intracellular signaling that culminates in integrin activation, leukocyte arrest, and extravasation. The presence of chemokines at the endothelial lumen can help guide the movement of leukocytes through peripheral tissues during normal immune surveillance, host defense or inflammation. The expression and display of homeostatic or inflammatory chemokines therefore critically determine which leukocyte subsets extravasate and enter the peripheral tissues. Within the CNS, however, infiltrating leukocytes that cross the endothelium face additional boundaries to parenchymal entry, including the abluminal presence of localizing cues that prevent egress from perivascular spaces. This review focuses on the differential display of chemokines along endothelial surfaces and how they impact leukocyte extravasation into parenchymal tissues, especially within the CNS. In particular, the display of chemokines by endothelial cells of the blood brain barrier may be altered during CNS autoimmune disease, promoting leukocyte entry into this immunologically distinct site. Recent advances in microscopic techniques, including two-photon and intravital imaging have provided new insights into the mechanisms of chemokine-mediated capture of leukocytes within the CNS. © 2010 Elsevier B.V.
The role of antigen presenting cells in multiple sclerosisEmily M L Chastain | D'Anne S. Duncan | Jane M. Rodgers | Stephen D. Miller
Volume 1812, Issue 2, February 2011, Pages 265-274
Multiple sclerosis (MS) is a debilitating T cell mediated autoimmune disease of the central nervous system (CNS). Animal models of MS, such as experimental autoimmune encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) have given light to cellular mechanisms involved in the initiation and progression of this organ-specific autoimmune disease. Within the CNS, antigen presenting cells (APC) such as microglia and astrocytes participate as first line defenders against infections or inflammation. However, during chronic inflammation they can participate in perpetuating the self-destructive environment by secretion of inflammatory factors and/or presentation of myelin epitopes to autoreactive T cells. Dendritic cells (DC) are also participants in the presentation of antigen to T cells, even within the CNS. While the APCs alone are not solely responsible for mediating the destruction to the myelin sheath, they are critical players in perpetuating the inflammatory milieu. This review will highlight relevant studies which have provided insight to the roles played by microglia, DCs and astrocytes in the context of CNS autoimmunity. © 2010 Elsevier B.V.
Brain aging, Alzheimer's disease, and mitochondriaRussell H. Swerdlow
Volume 1812, Issue 12, December 2011, Pages 1630-1639
The relationship between brain aging and Alzheimer's disease (AD) is contentious. One view holds AD results when brain aging surpasses a threshold. The other view postulates AD is not a consequence of brain aging. This review discusses this conundrum from the perspective of different investigative lines that have tried to address it, as well as from the perspective of the mitochondrion, an organelle that appears to play a role in both AD and brain aging. Specific issues addressed include the question of whether AD and brain aging should be conceptually lumped or split, the extent to which AD and brain aging potentially share common molecular mechanisms, whether beta amyloid should be primarily considered a marker of AD or simply brain aging, and the definition of AD itself. © 2011 Elsevier B.V.
Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: Implications for early intervention and therapeuticsPeizhong Mao | P. Hemachandra Reddy
Volume 1812, Issue 11, November 2011, Pages 1359-1370
Alzheimer's disease (AD) is an age-related progressive neurodegenerative disease affecting thousands of people in the world and effective treatment is still not available. Over two decades of intense research using AD postmortem brains, transgenic mouse and cell models of amyloid precursor protein and tau revealed that amyloid beta (Aβ) and hyperphosphorylated tau are synergistically involved in triggering disease progression. Accumulating evidence also revealed that aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction initiate and contributes to the development and progression of the disease. The purpose of this article is to summarize the latest progress in aging and AD, with a special emphasis on the mitochondria, oxidative DNA damage including methods of its measurement. It also discusses the therapeutic approaches against oxidative DNA damage and treatment strategies in AD. © 2011 Elsevier B.V.
Th1 versus Th17: Are T cell cytokines relevant in multiple sclerosis?Amy E. Lovett-Racke | Yuhong Yang | Michael K. Racke
Volume 1812, Issue 2, February 2011, Pages 246-251
Our understanding of the pathophysiology of multiple sclerosis (MS) has evolved significantly over the past two decades as the fields of immunology and neurobiology provide new avenues of exploration into the cause and mechanism of the disease. It has been known for decades that T cells have different cytokine phenotypes, yet the cytokine phenotype of pathogenic T cells in MS is still an area of debate. In EAE, it appears that IFNΓ and IL-17, produced by Th1 and Th17 cells respectively, are not the critical factor that determines T cell encephalitogenicity. However, there are molecules such as IL-23, T-bet and STAT4, that appear to be critical, yet it is unclear whether all these molecules contribute to a common, yet undefined pathway, or act in a synergistic manner which culminates in encephalitogenicity has still to be determined. Therefore, the focus of research on effector T cells in MS should focus on pathways upstream of the cytokines that define Th1 and Th17 cells, since downstream products, such as IFNΓ and IL-17, probably are not critical determinants of whether an effector T cells is capable of trafficking to the CNS and inducing inflammatory demyelination. © 2010 Elsevier B.V.
Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistanceByung Cheol Lee | Jongsoon Lee
Volume 1842, Issue 3, March 2014, Pages 446-462
There is increasing evidence showing that inflammation is an important pathogenic mediator of the development of obesity-induced insulin resistance. It is now generally accepted that tissue-resident immune cells play a major role in the regulation of this obesity-induced inflammation. The roles that adipose tissue (AT)-resident immune cells play have been particularly extensively studied. AT contains most types of immune cells and obesity increases their numbers and activation levels, particularly in AT macrophages (ATMs). Other pro-inflammatory cells found in AT include neutrophils, Th1 CD4 T cells, CD8 T cells, B cells, DCs, and mast cells. However, AT also contains anti-inflammatory cells that counter the pro-inflammatory immune cells that are responsible for the obesity-induced inflammation in this tissue. These anti-inflammatory cells include regulatory CD4 T cells (Tregs), Th2 CD4 T cells, and eosinophils. Hence, AT inflammation is shaped by the regulation of pro- and anti-inflammatory immune cell homeostasis, and obesity skews this balance towards a more pro-inflammatory status. Recent genetic studies revealed several molecules that participate in the development of obesity-induced inflammation and insulin resistance. In this review, the cellular and molecular players that participate in the regulation of obesity-induced inflammation and insulin resistance are discussed, with particular attention being placed on the roles of the cellular players in these pathogeneses. This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease. © 2013 Elsevier B.V.
Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeuticsP. Hemachandra Reddy | Raghav Tripathi | Quang Troung | Karuna Tirumala | Tejaswini P. Reddy | Vishwanath Anekonda | Ulziibat P. Shirendeb | Marcus J. Calkins | Arubala P. Reddy | Peizhong Mao | Maria Manczak
Volume 1822, Issue 5, May 2012, Pages 639-649
Synaptic pathology and mitochondrial oxidative damage are early events in Alzheimer's disease (AD) progression. Loss of synapses and synaptic damage are the best correlates of cognitive deficits found in AD patients. Recent research on amyloid beta (Aβ) and mitochondria in AD revealed that Aβ accumulates in synapses and synaptic mitochondria, leading to abnormal mitochondrial dynamics and synaptic degeneration in AD neurons. Further, recent studies using live-cell imaging and primary neurons from amyloid beta precursor protein (AβPP) transgenic mice revealed reduced mitochondrial mass, defective axonal transport of mitochondria and synaptic degeneration, indicating that Aβ is responsible for mitochondrial and synaptic deficiencies. Tremendous progress has been made in studying antioxidant approaches in mouse models of AD and clinical trials of AD patients. This article highlights the recent developments made in Aβ-induced abnormal mitochondrial dynamics, defective mitochondrial biogenesis, impaired axonal transport and synaptic deficiencies in AD. This article also focuses on mitochondrial approaches in treating AD, and also discusses latest research on mitochondria-targeted antioxidants in AD. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease. © 2011 Elsevier B.V.
Genetics and molecular basis of human peroxisome biogenesis disordersHans R. Waterham | Merel S. Ebberink
Volume 1822, Issue 9, September 2012, Pages 1430-1441
Human peroxisome biogenesis disorders (PBDs) are a heterogeneous group of autosomal recessive disorders comprised of two clinically distinct subtypes: the Zellweger syndrome spectrum (ZSS) disorders and rhizomelic chondrodysplasia punctata (RCDP) type 1. PBDs are caused by defects in any of at least 14 different PEX genes, which encode proteins involved in peroxisome assembly and proliferation. Thirteen of these genes are associated with ZSS disorders. The genetic heterogeneity among PBDs and the inability to predict from the biochemical and clinical phenotype of a patient with ZSS which of the currently known 13 PEX genes is defective, has fostered the development of different strategies to identify the causative gene defects. These include PEX cDNA transfection complementation assays followed by sequencing of the thus identified PEX genes, and a PEX gene screen in which the most frequently mutated exons of the different PEX genes are analyzed. The benefits of DNA testing for PBDs include carrier testing of relatives, early prenatal testing or preimplantation genetic diagnosis in families with a recurrence risk for ZSS disorders, and insight in genotype-phenotype correlations, which may eventually assist to improve patient management. In this review we describe the current status of genetic analysis and the molecular basis of PBDs. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of peroxisomes in Health and Disease. © 2012 Elsevier B.V..
O-GlcNAcylation is a novel regulator of lung and colon cancer malignancyWenyi Mi | Yuchao Gu | Cuifang Han | Haiyan Liu | Qiong Fan | Xinling Zhang | Qi Cong | Wengong Yu
Volume 1812, Issue 4, April 2011, Pages 514-519
O-GlcNAc is a monosaccharide attached to serine or threonine hydroxyl moieties on numerous nuclear and cytoplasmic proteins; O-GlcNAcylation is dynamically regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Although recent studies have shown that O-GlcNAcylation plays essential roles in breast cancer progression, it is also necessary to know whether O-GlcNAcylation is involved in other types of human cancer. In this study, O-GlcNAcylation levels and the expressions of OGT and OGA in human lung and colon cancer tissues were examined by immunohistochemistry analysis. We found that O-GlcNAcylation as well as OGT expression was significantly elevated in the cancer tissues compared with that in the corresponding adjacent tissues. Additionally, the roles of O-GlcNAcylation in the malignancy of lung and colon cancer were investigated in vitro. The results showed that O-GlcNAcylation markedly enhanced the anchorage-independent growth of lung and colon cancer cells; O-GlcNAcylation could also enhance lung and colon cancer invasion in a context-dependent manner. All together, this study suggests that O-GlcNAcylation might play important roles in lung and colon cancer formation and progression, and may be a valuable target for diagnosis and therapy of cancer. © 2011.
Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neuronsMarcus J. Calkins | P. Hemachandra Reddy
Volume 1812, Issue 4, April 2011, Pages 507-513
Loss of synapses and synaptic damage are the best correlates of cognitive decline identified in patients with Alzheimer's disease (AD), and mitochondrial oxidative damage and synaptic pathology have been identified as early events in the progression of AD. The progressive accumulation of amyloid beta (Aβ) in synapses and synaptic mitochondria are hypothesized to cause synaptic degeneration and cognitive decline in patients with AD. However, the precise mechanistic link between Aβ and mitochondria is not well understood. The purpose of this study was to better understand the effects of Aβ on mitochondrial axonal transport and synaptic alterations in AD. Using mouse hippocampal neurons and Aβ25-35 peptide, we studied axonal transport of mitochondria, including mitochondrial motility, mitochondrial length and size, mitochondrial index per neurite, and synaptic alterations of the hippocampal neurons. In the PBS-treated neurons, 36.4±4.7% of the observed mitochondria were motile, with 21.0±1.3% moving anterograde and 15.4±3.4% moving retrograde and the average speed of movement was 12.1±1.8μm/min. In contrast, in the Aβ-treated neurons, the number of motile mitochondria were significantly less, at 20.4±2.6% (P<0.032), as were those moving anterograde (10.1±2.6%, P<0.016) relative to PBS-treated neurons, suggesting that the Aβ25-35 peptide impairs axonal transport of mitochondria in AD neurons. In the Aβ-treated neurons, the average speed of motile mitochondria was also less, at 10.9±1.9μm/min, and mitochondrial length was significantly decreased. Further, synaptic immunoreactivity was also significantly less in the Aβ-treated neurons relative to the PBS-treated neurons, indicating that Aβ affects synaptic viability. These findings suggest that, in neurons affected by AD, Aβ is toxic, impairs mitochondrial movements, reduces mitochondrial length, and causes synaptic degeneration. © 2011 Elsevier B.V.

subset: commoncrawl


text:
Dental Laboratory Insurance
We are able to provide cover on our exclusive scheme facility for insurance for Dental Laboratories.
Discounts available to DTA / DLA and DAMAS Members
We are able to provide the following key covers:-
- Stock incl stock of Gold
- Contents Insurance including Computers etc
- All Risks Equipment Anywhere in the UK
- Employers and Public Liability
- Business Interruption
- Hired in Plant / Equipment - automatically covered
Please call us for a Laboratory Quotation
Indemnity Cover
Indemnity Cover - Providing protection for incorrect Advice.
Includes cover for Shading Consultations, Advice to Surgeons and Supervision of Process Workers.
Cover Provided:-
- Professional Indemnity - £4,000,000
- Public / Products Liability - £4,000,000
- Defence Costs in Disciplinary Proceedings - £100,000
- No Excess
Premium - £47-00 per technician
Please contact Suzanne or Martin to discuss this area - we would welcome your input and would relish the chance to advise on and provide a quotation / recommendations for your particular circumstances:-
Suzanne Mazey
Suzanne joined UK Special Risks in 2003 and is a key member of the team. Her accuracy and diligence coupled with a task focused approach means that she is a valuable and longstanding employee. She has a detailed knowledge of both our Health Food Shop and Dental Laboratory products. Suzanne is efficient and effective in getting the job done and her organised and methodical approach achieves outstanding results.
Direct Dial: 01634 662916
Email: email@example.com
Martin Bell BSc FCII
Martin is the Managing Director of UK Special Risks and with over 25 years of knowledge and experience he is a referral point for complex issues. His wealth of knowledge and expertise allows him to make recommendations on practically any class of Commercial Insurance. Martin specialises in cover for the Construction Industry particularly Specialist Sub-Contractors. He has a calm and personable manner and is always happy to advise and help.
Direct Dial: 01634 662911
Email: firstname.lastname@example.com


text:
UninsuredSee more about Uninsured
Refine Results
- view as grid
- view as list
Key Data on Health and Health Coverage in South Carolina
This fact sheet draws on data from "Health and Health Coverage in the South: A Data Update" to highlight findings for South Carolina. The findings show the current status of health and health coverage in the state and the potential coverage gains that may be achieved through the Affordable Care Act.Fact Sheet Read More
Health and Health Coverage in the South: A Data Update
This brief provides key data on the South and the current status of health and health coverage in the South to provide greater insight into the health needs in the region and the potential coverage gains that may be achieved through the ACA. It includes data on the uninsured, Medicaid expansion and eligibility for coverage.Issue Brief Read More
Women's Health Insurance Coverage
This fact sheet provides updated statistics on health coverage and describes the major sources of health insurance for non-elderly adult women ages 18–64, including employer-sponsored or job-based coverage, Medicaid, insurance in the individual market, and Medicare. It also provides data on uninsured women, and summarizes the major implications of the Affordable Care Act (ACA) for women and their health coverage.Fact Sheet Read More
The Affordable Care Act Doesn't Rank Highly As an Issue for Voters in the Presidential Primaries
Despite Anecdotal Reports about Narrow Networks, 87% of Working-Age Adults with Insurance Are Satisfied With Their Plan's Choice of Doctors; 12% Say They Had to Change Doctors in Past Year As the ACA's Open Enrollment Nears End, Most of Those Who Remain Uninsured Are Disengaged While this month Congress passed…News Release Read More
Kaiser Health Tracking Poll: January 2016
Despite the ongoing debate between Republican lawmakers and President Obama on the future of the 2010 health care law, the January Kaiser Health Tracking Poll finds the Affordable Care Act (ACA) is only one of many issues that may impact voting decisions. While there has been recent focus on improving the value of health care, those with insurance under 65 years old largely say the health care services they receive are at least a good value for what they pay for them. Also, in the final days of the 2016 open enrollment period, many uninsured are largely disengaged from the health care system and opportunities for coverage, with large majorities being unaware of the date for the upcoming deadline to enroll or of the fine for not having health insurance in 2016.Poll Finding Read More
Data Note: Abbreviated January 2016 Health Tracking Poll Topline
This is an abbreviated topline for the upcoming January 2016 Kaiser Health Tracking Poll. It contains the survey questions addressed in Drew Altman's column, "Candidate Policy Plans Resonate More With Democrats. Here's Why," for The Wall Street Journal's Think Tank.Poll Finding Read More
New Estimates of Eligibility for ACA Coverage among the Uninsured
Under the Affordable Care Act, as of 2014, Medicaid coverage is extended to low-income adults in states that have opted to expand eligibility, and tax credits are available for middle-income people who purchase coverage through a health insurance Marketplace. Millions of people have enrolled in these new coverage options, but millions of others are still uninsured. This analysis provides national and state-by-state estimates of eligibility for ACA coverage options among those who remained uninsured. It is based on Kaiser Family Foundation analysis of the 2015 Current Population Survey, combined with other data sources.Issue Brief Read More
Who is Impacted by the Coverage Gap in States that Have Not Adopted the Medicaid Expansion?Slideshow Read More
The Coverage Gap: Uninsured Poor Adults in States that Do Not Expand Medicaid – An Update
In states that do not implement the Medicaid expansion under the Affordable Care Act (ACA), many adults will fall into a "coverage gap" of earning too much to qualify for Medicaid but not enough to qualify for Marketplace premium tax credits. Nationwide, over three million poor uninsured adults are in this situation. This brief presents estimates of the number of people in non-expansion states who could have been reached by Medicaid but instead fall into the coverage gap, describes who they are, and discusses the implications of them being left out of ACA coverage expansions.Issue Brief Read More


text:
Cooking How-To
Learn cooking basics and advanced techniques through our comprehensive how-to's and step-by-step guides on everything from peeling ginger to cooking a perfect risotto in a few simple steps.
15 Mouthwatering Recipes from the Grill
Recipes and inspiration for your most delicious grilling season to date.
4 New Ways to Reinvent Coconut Cake
Updated takes on a dessert classic, but don't worry, all "light and fluffy" qualities are preserved.
3 Timeless Recipes from a Grandmother Baker
Recipes and tips for baking like a grandmother, by New Zealand granny, Dulcie May Booker.
How to Make Hand-Crafted Candy Bars
Candy bar connoisseurs share their tips and recipes for making grown-up, homemade versions of childhood favorites.
12 Essential Sauce Tips You Need to Know
Words of advice on cooking luscious sauces along with 15 flavorful sauce recipes.
5 New Takes On Potato Salad
Hit the picnic circuit this year with fresh potato salad recipes sure to please.
11 Easy Ways to Cook Like a Chef
Simple tips from Chef Maria Elia on how to think—and cook—like a chef in the kitchen.
18 Fresh Recipes Using Spring Greens
Take advantage of this season's spring greens with these mouthwatering recipes.
California Raisin Winning Recipes
Meet the winner of our California Raisins recipe contest, and her winning pork loin.
The 11 Spring Greens that Make Up Mesclun
Sometimes called "spring mix," mesclun is a bright fresh combination of a variety of salad greens.
This and That: March 2013
National Nutrition Month, Easter, the annual Relish breakfast issue—March is a big month.


text:
Hugh Grant
Born on September 9, 1960
From London, England
Hugh Grant as "Will"
A comedy-drama starring Hugh Grant as Will, a rich, child-free and irresponsible Londoner in his thirties who, in search of available women, invents an imaginary son and starts attending single parent meetings. As a result of one of his liaisons, he meets Marcus, an odd 12-year-old boy with problems at school. Gradually, Will and Marcus become friends, and as Will teaches Marcus how to be a cool kid, Marcus helps Will to finally grow up.
|Golden Globe (2002)
|Best Performance By an Actor in a Motion Picture - Comedy or Musical
Hugh Grant as "William Thacker"
William Thacker (Hugh Grant) is a London bookstore owner whose humdrum existence is thrown into romantic turmoil when famous American actress Anna Scott (Julia Roberts) appears in his shop. A chance encounter over spilled orange juice leads to a kiss that blossoms into a full-blown affair. As the average bloke and glamorous movie star draw closer and closer together, they struggle to reconcile their radically different lifestyles in the name of love.
|Golden Globe (1999)
|Best Performance By an Actor in a Motion Picture - Comedy or Musical
Four Weddings and a Funeral (1994)
Hugh Grant as "Charles (Wedding one)"
Lovable Englishman Charles (Hugh Grant) and his group of friends seem to be unlucky in love. When Charles meets a beautiful American named Carrie (Andie MacDowell) at a wedding, he thinks his luck may have changed. But, after one magical night, Carrie returns to the States, ending what might have been. As Charles and Carrie's paths continue to cross -- over a handful of nuptials and one funeral -- he comes to believe they are meant to be together, even if their timing always seems to be off.
|British Academy of Film & Television Arts (1994)
|Actor in a Leading Role
|Golden Globe (1994)
|Best Performance By an Actor in a Motion Picture - Comedy or Musical


text:
Green Party candidate faces charges in graffiti protest
As of late Tuesday, Stein was not arrested or charged in the incident.
As of late Tuesday, Stein was not arrested or charged in the incident.
Authorities were notified by the owner of the truck who saw that it was being sold on Craigslist and believed the seller was in the Jackson …
A 70-year-old man accused of robbing a bank in Kansas told investigators he would rather be imprisoned than live with his wife.
Thirteen women who say Bill Cosby drugged and sexually assaulted them over the years have agreed to testify against him in the only criminal…
Her life with a new face was a miracle to many, but was also marred by infections, kidney trouble and hypertension linked to her treatment.
An American Indian tribe succeeded Tuesday in getting a federal judge to temporarily stop construction on some, but not all, of a $3.8 billi…
A woman found lying near the body of her disabled son in a southwest Missouri field has been charged in the teen's death.
The speedway that calls itself the "last great Colosseum" now will be temporarily transformed into the world's largest football stadium.
"I'm sure we'll have a successful outcome to make sure just that the trains are running on time."
Police are investigating a possible murder-suicide after a teen found her mother and stepfather dead in Kansas City, Kansas.
It took an act of Congress, but World War II pilot Elaine Harmon is finally being laid to rest on Wednesday at Arlington National Cemetery.
Diagnosed with cancer, LSU's live tiger mascot, Mike VI, won't take the field during home football games this season but will remain in his …
"He's not getting away with anything."
As millions of Americans prepare to celebrate Labor Day as one last summer vacation, both the Democratic and Republican Presidential candida…
Hard-core Apple fans will be watching closely for details about the newest features coming to Apple's gadget
"You're stealing from people who work every day to just get by."
The Kansas Humane Society CEO posted a letter to Facebook on Labor Day, asking people to stop harassing his employees and thank them for the…
A teen girl found dead in a North Raleigh pool Saturday afternoon drowned after entering the electrified water.


text:
Informatie en kansen voor jongeren in heel Europa.
If you find yourself with time to spare, why not do something for others?
Beschikbare talen
Are you a translation graduate or student interested in institutional translation and EU affairs? Check out what the European Parliament has to offer to young linguists and get to know how EU legislation gets translated into your language!
Beschikbare talen


text:
Larry Fitzgerald
Football Player + Wide Receiver
Born Aug 31, 1983
Larry Darnell Fitzgerald, Jr. is an American football wide receiver for the Arizona Cardinals of the National Football League (NFL). He played college football for the University of Pittsburgh, and earned All-American honors. The Arizona Cardinals chose… Read More
View newly released photos of Larry Fitzgerald.
News + Updates
Browse recent news and stories about Larry Fitzgerald.
The Los Angeles Rams Are Looking Forward To The Return Of Cornerback E.J. GainesLATimes - 3 days ago
Fantasy Football: Players To Start In Week 3NYTimes - 9 days ago
2016 Nfl Contenders And PretendersHuffington Post - Sep 06, 2016
Packers Hold A Whine And Cheesed Off PartyChicago Times - Jan 19, 2016
Learn about the memorable moments in the evolution of Larry Fitzgerald.
1983 Birth Born on August 31, 1983.
2002 18 Years Old He was widely considered one of the best wide receivers in college football from 2002 to 2003.
2003 19 Years Old 3 More Events
After his sophomore season, Fitzgerald was recognized as the best player in the NCAA with the 2003 Walter Camp Award and the Touchdown Club of Columbus's Chic Harley Award, and as the best wide receiver in college football with the 2003 Biletnikoff Award and the Touchdown Club's Paul Warfield Award.
2004 20 Years Old 3 More Events
Although Fitzgerald had played at Pitt for only two years without redshirting, he petitioned the NFL to allow him to enter the 2004 NFL Draft, as he had left his high school, Academy of Holy Angels, during his senior year to attend Valley Forge Military Academy. … Read More
2007 23 Years Old 1 More Event
As part of his 2007 Pro Bowl season, he caught 100 receptions for 1,409 yards and 10 touchdowns.
2008 24 Years Old During the NFC Championship for the 2008 NFL season, Fitzgerald tied an NFL record with three touchdown receptions in a playoff game. … Read More
2009 25 Years Old Despite having about 300 yards less than the year before, he set a personal record with 13 touchdowns in 2009. … Read More
2011 27 Years Old On August 20, 2011, Fitzgerald signed an 8-year $120 million deal with the Arizona Cardinals, tying him with Richard Seymour as the 5th highest paid player in the NFL. … Read More
2012 28 Years Old 1 More Event
Following the 2012 football season, Fitzgerald was named the "Arizona Cardinals/Walter Payton NFL Man of the Year" and was one of three finalists for the Walter Payton NFL Man of the Year Award.
2013 29 Years Old 2 More Events
2014 30 Years Old 1 More Event
In May, 2014, Fitzgerald and Lenovo provided five schools in Minneapolis and four schools in Phoenix Lenovo tablets and equipment to enable the children to gain access to technology. … Read More
2015 31 Years Old On February 18, 2015, Fitzgerald was signed to a new multi-year contract worth at least $11 million guaranteed over the next two seasons.
Original Authors of this text are noted on http://en.wikipedia.org/wiki/Larry_Fitzgerald.
Text is made available under the Creative Commons Attribution-ShareAlike License.
Text is made available under the Creative Commons Attribution-ShareAlike License.


text:
Apple just announced that the iPhone will be available in 50 more countries starting December 14. Shortly after Apple made the announcement, both Globe and Smart have officially posted announced via their respective Twitter accounts that indeed the iPhone 5 will be released in Manila, Philippines on the said date.
Although no details yet were provided by both telcos, it has now become a battle of who's going to get the most number of subscribers who will get the iPhone 5 and will eventually subscribe to a new plan.
For Globe subscribers, if you want to get ahead of the pack, Yugatech has posted that Globe has already activated its sign-up page for the iPhone 5. You can check out this link. From there you can enter your personal details for Globe to contact you once the iPhone 5 is already available.
As for Smart, no detailes are available as to how they are going to carry out the launch of the iPhone 5.
So, now, it's up for you to decide. From which telco are you going to get your iPhone 5?


text:
This page belongs to a cute young girl by the name of Courtney.
If you have anything you wish to say to Courtney then just write it on her wall.
The one writing this bio is her friend, Laci.
Both Laci and Courtney have a seriously unhealthy love for Detective Conan.
Courtney is watching Detective Conan which is why Laci is writing her bio.
Laci has already seen this episode of Detective Conan.
Well, Bye bye Otaku of Anime-Planet!
Sooooo......hi. I thought I might as well write here myself!!! I am heart2love13. Or well Courtney since my friend already blew my cover. So to call myself heart2love13 is a little ridiculous.
I have recently become kinda obsessed with anime. I was more into manga, but now it's more equal.
SOMEONE!!! Watch Canaan!!! Or The World God Only Knows!!! Or Xam'd!!!
Did you know anime was EXPENSIVE?!?! See, I only learned this like 2 days ago.
By the time you read this, this will probably be outdated....but I'm really not good at writing about myself...
Bye bye!!! <3
1,263 total episodes
Thank you! Am now following you! Keep in touch and leave me a comment on my profile page any time - I'd love to hear from you!
Hello! sothis is redesigning the anime-planet site, and plans to roll out an awesome new site design in July, we believe. The blog feature is not part of the new design, and it is going away. More information about this here: Announcement: the blog feature is being deprecated topic link. (Be sure to check out the new site design when it goes live!)
The blog pages are going away, and will be gone when the site redesign goes live. Your blog here will be removed from the site.
So, if want to keep the information posted in your blog, you will need to copy this information someplace else on the site. If you have any questions how or where to do this, please feel free to get back to me, and I will try to assist.
Hey! =]
Yea As far as I remember I read your most recent blog...... it had something about Princess Tutu. I don't usually read blogs on AP...Only when I'm trying to kill time/ find new anime.
Anyway I must say that blog was fairly entertaining XD......I mean even if you were angry at least you got to complain/voice your opinion....Don't misunderstand me I mean it in a positive way =]
I actually expected you to say that about your avatar...I mean it looked like a picture I say before.
Talking about recommendations.........You should try Death Note, Mirai Nikki, Durarara and Utawarerumono. It's kind of herd recommending something if you don't know what a person likes so let me know if you liked any of them. =]
BTW It looks like we are even.....You left me a long comment now I'm doing the same. =D
I stumbled upon your profile while browsing the blog section of the site xD and I just wanted to say that you have quite an interesting description on your profile. I mean most descriptions are……I'm not sure if that's the best word to describe them but they are unimaginative. xD
BTW where is your avatar from? an anime?
Oh yea let me know if you are ever looking for anime recommendations. I might be able to come up with something considering I like 2/3 of your favorite genres xD
Have you heard of an anime called Lovely Idol? It seems like something that would interest you!
Look it up!


text:
Books & Novels
The books & novels shown here were created by teens. Click any thumbnail to view the book or novel.
In the end
By Michael O., MORRISTOWN, NJ
A man thinks that he is the last man alive on earth, but he will find something much different.(more »)
1 comment
The Madison Stiles Chronicles
The Madison Stiles Chronicles is set in Charlotte North Carolina during a zombie outbreak. In this chapter you will be following two teens in love trying to escape the mayham in the city.(more »)
Postcards from the Island
This is the beginning of what hopefully will be a series about life on an island for a group of teenagers just looking for something to do. This is just the first two chapters, let me know if you want more! (more »)
Im With The Band
"we must continue our quest to devour in order to fill our empty existance."-Skylar Stone. (more »)
3 comments
The Weak's End
An enchanting dark love story about two teenagers seperated by the two worlds the high-school has placed them in. Their meeting being only chance. Could something so obviouslty forbidden win against these foreign feelings in any plausible way? (more »)
Two kid's , One love .
Two kids . One love . Will it last ? (more »)


text:
Sounding great on Reverbnation today!
If you have time listen to my music and fan me back.
Alex Skarred Kage
Stumbled upon your sound surfing the Reverb site...Nice Sound!
keep grinding fam.. fan back one time..
Butterflies Radio is proud to have your song "Under Curb" on our rotation! Please check out our web page for all our links and details of our TWITTER TUESDAY LIVE SHOW. Great to have you with us! http://www.butterfliesradio.com/home/twitter-tuesday-live/
Congrats again on winning last night! You totally rocked the Hard Rock! See you at Jet!
LOVING THE VIDEO! Can't wait until the band makes it big!
I think this new video is ready for primetime, This band is well on its way to the Big leagues.
I get your songs stuck in my head all the time! Love it! Thanks for groovin blasts and....the earworms! lol
Thank You..
Diggin the vibe of rock band mixed with emceeing.... keep it on!


text:
A sweet treat for your Grad guests!
Our exclusive Personalized Graduation Hats Candy Jars are a colorful way to treat your party guests! Each Graduation Hats Candy Jar measures approximately 3 inches high x 2 1/2 inches wide with a 1 3/4 inch opening and are made of glass. These personalized candy jars are great for nuts, candy, and all your fun treats! Minimum order of 12.
Please allow ample time for delivery. Our ship date for this product is noted in your shopping cart. Many items are shipped separately, so please allow extra time for these items to arrive. Shipping charges are based on the value of the merchandise and not the number of shipments. For additional shipping information, please contact our Customer Service Department at (firstname.lastname@example.com or 1-800-314-8794).
Reviewed by 1 customer
Best Uses
Filled with small candies and gave as favors.
They were a huge hit.
Do you have questions about this product?
Get answers from real customers and in-house experts with AnswerBox.
Q:How permanent is the design on the top. Is there a possibility that the desigh will rub off? We want to use these for our 50 class reunion favor. Good idea?
1 answer
A:The design will not rub off. We do not offer M&M's.


text:
Culture-Dependent Assimilation and Differentiation of the Self
Jennifer Aaker
Stanford University - Graduate School of Business
Bernd H. Schmitt
Columbia Business School - International Business
Journal of Cross Cultural Psychology, Vol. 32, pp. 561-576, September 2001
In two studies, we investigate how differences in self-construal patterns affect preferences for consumption symbols through the process of self-expression. The results of Study 1 demonstrate that individuals with a dominant independent self-construal bold attitudes that allow them to express that they are distinct from others. In contrast, individuals with a dominant interdependent self-construal are more likely to hold attitudes that demonstrate points of similarity with their peers. Study 2 provides additional evidence for the mechanism presumed to underlie the results by identifying differential schematic processes as the driver of expressed preferences. We find that differential levels of recall for similar and distinct items exist across culturally-encouraged selves, documenting higher recall for schema-inconsistent information. We discuss the results and encourage future research that expands the framework to group decisions and social preferences.
Keywords: culture, assimilation, differentation, consumption, symbols, consumer
JEL Classification: M30, M31
Date posted: August 6, 2011
Suggested Citation
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CNN PRODUCER NOTE JohnUCSD has been iReporting on multiple protests in recent days on UC San Diego campus, the latest being in response to a noose found in the campus library, according to CNN affiliates. A student admitted Friday to police at the University of California San Diego that she hung a noose Thursday night in a campus library, police said. JohnUCSD told me that students were occupying the chancellor's office. 'The videos I sent were of the students, staff and faculty demanding that the university take real action to deal with the problem of racism on campus and in the community.'- hhanks, CNN iReport producer
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ASUS Eee PC 900 (Windows XP version)
The popular ultraportable notebook is now bigger and also available with Windows XP
Price$ 599.00 (AUD)
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Kathy Cassidy
First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.
Anthony Grifoni
For work use, Microsoft Word and Excel programs pre-installed on the device are adequate for preparing short documents.
Steph Mundell
The Fujitsu LifeBook UH574 allowed for great mobility without being obnoxiously heavy or clunky. Its twelve hours of battery life did not disappoint.
Andrew Mitsi
The screen was particularly good. It is bright and visible from most angles, however heat is an issue, particularly around the Windows button on the front, and on the back where the battery housing is located.
Simon Harriott
My first impression after unboxing the Q702 is that it is a nice looking unit. Styling is somewhat minimalist but very effective. The tablet part, once detached, has a nice weight, and no buttons or switches are located in awkward or intrusive positions.
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text: r IRSKA | Digital Scrapbooking at Scrapbook Flair Home Galleries Groups Challenges Blogs Forums Members Downloads MarketPlace Store Archive Join Login offline Joined: Jan 5, 2008 Last Logon: Mar 16, 2014 IRSKA's Home Page www.scrapbookflair.com/IRSKA My name is Mojca (pronounced something like Moytza) and I'm from Slovenia, a very small country in Europe. I like to travel, take day trips around Slovenia, especially to the mountains. And I just love to take photos. I haven't been around SBF for a long time, but I'm glad the web-page is still "busy"! Keep up the good work, everybody! IRSKA is from LJUBLJANA, Gorenjska, Slovenia http://irskamojca.blogspot.com/ 1 1 IRSKA's Scrapbooks memories morning has broken ... over the mountains colorized climber email it » view all IRSKA's scrapbooks IRSKA's Favorite Scrapbooks » view all IRSKA's favorite scrapbooks IRSKA's Friends IRSKA has 210 friends » view all IRSKA's friends IRSKA's Fans IRSKA has 109 fans » view all IRSKA's fans Renew/Upgrade Membership Gallery Award Gallery Groups Blog Friends Favorites Tags Post and Share this page on Blogs and other Websites by copying and pasting this link: http://www.scrapbookflair.com/IRSKA IRSKA's home page has been visited 9322 times. About Us Bookmark Contact Us Designer Members FAQs Fan Mail Help Link to Us Membership News Privacy Search Site Rules Suggestion Box Tell a Friend © 2006-2016, Patent Pending, Aurora Digital Imaging, Ltd. Beta 5.0 The most fun digital scrapbooking site on the Internet. Free digital scrapbooking software, scrapbook templates, scrapbook embellishments and backgrounds. Beautiful scrapbook prints and photobooks.


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Skip to comments.Jennifer Wiener has passed away
Posted on 08/16/2013 5:12:09 PM PDT by mylife
What a shock. The Joke lady passed away in her sleep 8/4/13.
Listen to Allan's remembrance live
Any connection to Carlos Danger?
Jennifer would have fit in right here at FR.
She was a staunch Constitutionalist and Christian.
Sharp as a tack, software programmer, HAM operator, and prankster.
Wife of Allan Wiener, owners of WBCQ.
OMG she was a riot.
Wow two Weiner stories in a row...
It is shocking.
She was just on the radio the other week ripping Obama.
Allan is just informing the world, Calling Mal Fuller.
For those that do not know Mal Fuller is in the old folks home after losing his leg.
Jen was the one that saw him through those dark days.
Mal sounds alive in Jens passing, no thought for himself.
Mal is a liberal old curmudgeon.
God Bless Jen
Thanks for the condolences.
I chatted politics with her often.
Didn't she have some sort of health scare about 10 years ago. I remember an AWWW show mentioning she came out of some procedure OK.
Damn indeed. RIP.
Never heard of either of them but RIP Jennifer. She looks much too young to go.
She should have been a FReeper.
Hi there Bob.
I did not know this Lady... it appears very much to my loss. Prayers and condolences to her family and friends.
Sad WBCQ ping
I told her and Allan of FR often
She was a hoot Slim, she was a hoot.
Sad, that's what we need these days.
58 years old and cutting up just two weeks ago.
And she HATED OBAMA!
Well, we're in good company then!
Fascinating woman.
Allan really flipped political poles when he met her.
She was willing to work over liberals on day at a time and never gave up on them.
Terrible connection with Mr Mike, but Allan is not in the studio at Monticello Maine.
He is in the remote site in Fla, and certainly not at the top of his game tonight.
It is amazing that he is so together.
Eldon says, you can not kill energy.
No two wieners are a like.
Much MUCH to young to go!
She was only 43 years old?
What is going on?
I don't know this person, so I googled her. BUT found nothing of her death. I spelled it both Weiner. and Wiener, but nothing. Even used the words 'death', and 'passing', but still nothing.
What gives? What am I missing?
I went to the radio station from the link here and there was nothing there that I could find. I can't seem to find anything about her at least the one you're speaking about. Sorry, just confused and now my curiosity is up.Can someone help? Thanks.
Ditto here.
I remember Alan Wiener, Pirate Joe and Big Steve Cole from Radio New York International back in the 1980's and 1990's. I liked the show where they played records that were only made into 78's. I was surprised to hear they still used the 78 format on songs from the Rolling Stones.
I was shocked. I thought for sure the sad new was going to be Mal Fullers passing. Very, very sad news. I hope Allan can keep going.
Wrong Jennifer Weiner in that youtube video.
I had no idea she had a defective heart valve.
I did not know that about 78's
There is a picture of her here
1st pic in the 4th row.
Thanks mylife! Interesting-—that is definitely not the same woman that came up on the Google search and video link.
They lead interesting lives.
I think some 78's were made well into the mid 1960's. I did a quick search and there where 78's the Beatles made that were sold mainly in India. IIRC, Weiner, Pirate Joe and Big Steve Cole played Rolling Stones and Dave Clark Five 78's. I remember in the late 1980's, I did correspond with Big Steve Cole on Fidonet. Fidonet was like a electronic pony express of BBS'es.
Ahh.. BBS's; before there was Windows 3.0 there was Xtree.
Remembrance of Jennifer...
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EJ Park: Touching Us Softly with Her Song
She gets moving. Bold, and with a taste for adventure, Park throws herself into her work and studies, starts getting some gigs, and soon people start noticing her. They hear the simplicity and beauty of her singing. They see her dedication to the music. They are moved by the way she turns a unique phrase on an old standard. Says Park, "You have to know what you want to do in life and persist at it. I listened to an African American jazz singer on television, and from that moment I knew that's what I wanted to do. I have to be strong and be the best I can be."
The singer on TV in South Korea was the great Cassandra Wilson. Such high aspirations and quiet confidence along with her liquid soprano voice and musical discipline are among the qualities that are already leading Park on a path to success.
Park was early introduced to music. Born three years after the 1980 democratic uprising in her home city, and while there was still tension in the air, Park recalls that "My mother sheltered me from the violence I saw on the streets. But she and my father really loved to listen to music. Every morning, my father played records: jazz, classical pieces. Then my mother took me to a pianist for lessons, so I learned classical piano when I was five years old."
A prodigious talent, she gradually found herself gearing up to be a concert pianist. But, in college at Jeonnam National University, she found herself increasingly dissatisfied with the straight-ahead discipline of classical performance, longing for ways to creatively express her inner feelings, and acquiring a taste for singing. Only at her mother's urging did she complete her piano studies, doing so with panache. But that epiphany from listening to Cassandra Wilson stuck with her, and she sought the guidance of Malo, a Korean jazz singer who recommended she enroll at the Dong-Ah Institute for Media and the Arts (DIMA) for jazz studies. Soon thereafter she found an inspiring teacher, Sunny Kim, an avant-garde vocalist who had worked with the trombonist Roswell Rudd and was the first Korean to sing at the Newport Jazz Festival. Kim encouraged Park to study in the United States and walked her through the necessary skill assessment, and soon thereafter the aspiring jazz singer came to Philadelphia's UArts.
In the two plus years since then, Park completed her masters and was instantly hired as adjunct vocal faculty, joining the likes of Anne Sciolla and Mary Ellen Desmond. Beyond those achievements, and at last fulfilling her dream, she has been a busy vocalist and pianist, with over eighty nightclub gigs to her credit, and gospel singing tours with top Korean ensembles.
Sensing her enormous talent, her teacher and mentor, pianist Don Glanden, Head of Graduate Jazz Studies at UArts, brought her on board as vocalist with his acclaimed trio, and she has been a big hit with them at places like the Sullivan's Steak House in Delaware, the Azure Room at the Revel Casino in Atlantic City, the Ubon Thai Restaurant in Wilmington, and the Paris Wine Bar in the Fairmount section of Philadelphia. Robert and Benjamin Bynum, the legendary music entrepreneurs who founded the top Philly clubs Warmdaddy's and Zanzibar Blue, have booked her for their new establishment, the Paris Bistro and Jazz Café, in Chestnut Hill. When people hear her, they want her back. Says Glanden, "It's hard to find a young singer who is as resonant with the listeners and as dedicated to jazz as EJ. People hear an extraordinary level of honesty in her singing, a real desire to communicate. I booked her with bassist Bruce Kaminsky on an off night at Sullivan's, when folks are usually there to eat and drink, not listen, yet everyone was applauding, filling up the tip jar with bills, and people didn't want her to stop singing, they loved her so much. The level of honesty of her singing really reaches the musicians and the audience alike."


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[RCimini] 8:03 pm: Ready to talk some Jets?
[WestCoastOffensive] 8:04 pm: Hey hey Thank you Rich for your time
[JumbalayaJet] 8:05 pm: Rich, is Houston badly dinged, and what will it take to jump start the running game? Is our OL capable of opening the holes?
[RCimini] 8:06 pm: I don't think Houston is going to play this week. Look for Leon and Barlow against a tough Miami run defense. Yes, I think they can run on Miami, maybe 100-120 yds.
[Slappy McGhee] 8:07 pm: Rich: Mangini says great practice players get playing time but Blaylock is always inactive. He was practice player of the week. Whey doesn't he get playing time?
[RCimini] 8:08 pm: Good question, Slap. First of all, some of that practice stuff is just lip service from Mangini. I think he bases personnel decisions on 1. game performance, 2. game-plan strategy, 3. practice performance. I think he was throwing Blaylock a bone by giving him that recognition.
[Nocomment] 8:10 pm: Rich: Chad has been up and down this year. He had a fine game against Miami the first time around. Do you think the Jets will rely more on Chad or the run for this game? How effective can Barlow be against Miami?
[Slappy McGhee] 8:11 pm: Follow up...how did blaylock fall so far?
[RCimini] 8:12 pm: They won't rely on Chad more against Miami than Minny. They will try harder to run the ball. Miami is a big blitzing team, so you will see quick drops and hot reads. They don't have anyone who can block Taylor. As for Barlow, you might see 5 carries or so, but I suspect Leon will be the workhorse.
[WestCoastOffensive] 8:12 pm: Rich, any sign that Chad's shoulder is "hitting the wall" so to speak? Is he getting stronger, or losing strength?
[RCimini] 8:13 pm: West, if Chad's shoulder hit the wall, it would've happened a while ago. Do I think he's throwing as well as he did in September? No. But let's keep it in perspective. He had 2 operations. With a full offseason to train, and not rehab, he should be stronger next year.
[Jetspennyfan] 8:13 pm: Rich, what do most of the Jets REALLY think about Miller being their only Pro-Bowler, and is Mangini using this as a way to pump them up for the game against the Dolphins?
[RCimini] 8:15 pm: Maybe I'm missing something, but I didn't sense any outrage in the locker room. Watch, Cannizzaro will have that story in tomorrow's paper, kicking my butt. But, seriously, I didn't get that vibe from any players. Really, who got snubbed? Rhodes? Coles? You could make an argument for them, but no one else.
[SAR I] 8:15 pm: Rich: What's your take on Kellen Clemens progress this season? Many Jets fans see Vince Young, Jay Cutler, and Two Time National Champion and Heisman Trophy Winner Matt Leinart getting valuable experience and contributing as bonafide NFL starters. Have you seen anything from Kellen at all in practice to let you know that he's a player? Have you heard any inside scoop on whether the Jets are still high on him and/or regrest on passing on some of these other QB's?
[RCimini] 8:17 pm: As you know, we don't watch practice, but from what I hear, the team still is very high on Clemens. He should be their No. 2 next season, although I suspect they'll bring in another vet as insurance. Clemens has Chad-like intangibles, with a better arm. They really like him.
[SAR I] 8:17 pm: Great news. Thanks.
[Ikeyman3] 8:17 pm: Do you think the Jets will be big players in the free agent market this offseason or will they try to build through the draft as the Patriots do? What positions do you think the Jets will target in the first couple of rounds of the draft?
[RCimini] 8:20 pm: They will have about $27 M in cap room, so they can spend big bucks on a couple of free agents. Keep an eye on RB Michael Turner and CB Asante Samuel. In the first 2 rounds, obviously, they need a DE, DT, RB, CB...
[Jets Babe] 8:21 pm: Rich: Whats up with Coles? I heard he didnt practice this week. Think he'll play this week? He's a tough player...but thats really not like Coles to NOT practice...
[RCimini] 8:23 pm: Coles has been out there at practice, in uniform. I'd be shocked if he doesn't play. He will play.
[JMac] 8:23 pm: Mangold got nicked a little last week. Did he practice as usual, and will be be at 100% for Miami?
[RCimini] 8:24 pm: Mangold is a special dude. Nothing fazes him. He has missed only one snap all season. He has been practicing and he will defnitely play.
[freestater] 8:24 pm: Rich, How about the right side of the O-Line? Does the Coaching staff seem to be OK with their performance?
[freestater] 8:25 pm: will we be seeing replacements theis offseason?
[RCimini] 8:27 pm: Anthony Clement is strictly a stop-gap player. By my count, he has allowed about 10 sacks. If he's the starter in 07, they have problems. They really like this young kid, Na'Shan Goddard. This, too, is another area that will be addressed in the draft. RG Brandon Moore is solid and signed for several years. They like him.
[SAR I] 8:27 pm: Rich: Knowing what we know now, did Mike Tannenbaum underestimate the potential of the 2006 Jets and overreact in the offseason by committing the team to a rebuild prematurely? Would the Jets not be 1 or 2 games better in the standings today if we had the likes of a Mawae, Law, or Abraham and drafted for need (RB) and picked up some quality win-right-now free agents? Isn't the possibility that Tannenbaum just blew the division the dark cloud in this year's silver-lining Jets rebuilding story?
[freestater] 8:27 pm: cool, thanks
[RCimini] 8:29 pm: Great question, Sar. Short answer: I think Mike did it the right way, building for the long haul instead of going for the quick fix. Abe is always hurt, Law is done and Mawae ... he's still good, but I'd rather have a young Mangold. If you go for the quick fix, you end up in an endless cycle of big contracts and old players.
[Ikeyman3] 8:29 pm: Will the Jets try to sign either Kerry Rhodes, Jerricho Cotchery or Johnathan Vilma to contract extentions this offseason? Would Woody Johnson reward Mangini with a raise if he makes the postseason as he is one of the lowest paid coaches in the league "only" making 1.75 MM?
[RCimini] 8:32 pm: Rhodes and Vilma, no -- they're still signed for another 2 years, I believe. Cotchery is up after 07 and discussions could begin in the offseason on a new deal. Woody created a precedent by giving Herm a new deal after his first season, so it wouldn't surprise me.
[Ikeyman3] 8:32 pm: Thanks
[bill parcells] 8:32 pm: Hi Rich,is Mangini preaching the us against the world mentality this week going to Miami for xmas..
[RCimini] 8:33 pm: Tuna, no I don't think he's going that route. It might be us against Santa Claus --only kidding. There's plenty of built-in incentive for this game.
[Jetspennyfan] 8:34 pm: Rich, whats the story on Curtis Martin, are the Jets very likely going to have him retire, or is he really serious about coming back, and also one quick thing, I saw a report that Carson Palmer tore his rotator cuff, do you know if there is any truth to that at all? And will Schottenhiemer be leaving, because lots of people are saying he might get consideration for a head coaching job?
[bill parcells] 8:34 pm: Thanks Rich
[RCimini] 8:36 pm: Actually, I talked to Curtis briefly today in the locker room. I think the jets want him to retire, and I suspect he will. He basically announced his retirement the day they put him on IR. He's done. Heard those Palmer rumors, too, but don't have any confirmation. Schott, I think, has a bright future, but I don't think the head-coaching nibbles will start this soon -- unless it's a college situation. His alma mater, Florida, is doing pretty well, so I don't think he'll pull a Groh.
[SAR I] 8:37 pm: Rich: Herman Edwards is enroute to taking a 10-6 Larry Johnson Chiefs team to a terrific 8-8 record via his tremendous game planning, execution, and motivational skills. Can we now look back and say that had Woody Johnson chosen a better head coach back in 2001 that the Jets might have actually won a Super Bowl? We now know that those teams made the playoffs on sheer talent alone, being crippled by coaching; is not Herman Edwards one of the worst head coaches in NYJ history in retrospect?
[RCimini] 8:39 pm: Had a debate with Cannizzaro last week on this very subject. Guess which side he was on? No, Herm isn't one of the worst HC's in Jets history. What about Kotite? Coslet? Holtz? Winner? He was an average coach who achieved nice things, in large part, because of circumstances. (good roster, lucking into playoff berths, etc.)
[SAR I] 8:40 pm: BUT.....
[SAR I] 8:40 pm: Did he not waste tremendous talent whereas those other bad Jets coaches didn't have the horses?
[freestater] 8:40 pm: He's the DEVIL!!!!!!!!!!
[THE_SOOTHSAYER] 8:40 pm: lol
[VUJetsFan] 8:40 pm: Victor Hobson has been a beast this year. What has propelled him to step up this year, last year M. Brown played more than he did. Mangini?
[RCimini] 8:40 pm: Whoa! Tremendous talent? Did I miss something? he did have lose his QB in two seasons, remember?
[RCimini] 8:42 pm: VU, Hobson wasn't good in the 4-3 because I don't think he plays well in space. He's better in the 3-4 because he's fairly strong at the point of attack. He's also getting more chances to blitz, which I think is one of his strengths.
[Slappy McGhee] 8:42 pm: Rich, you've seen a lot of Jets coaches. How do you rate Mangini as a person and coach. Also, is it weird that it's been so quiet at Hofstra for a change? Usually it's a side show.
[VUJetsFan] 8:42 pm: thanks
[RCimini] 8:45 pm: Slap, yeah, I've seen a lot of Jets coaches. Actually talked to Joe Walton last week. Nice man. Mangini, too, is a nice guy. It's too early to rate him as a coach, but he clearly knows his stuff, prepares well, runs a tight ship, has a vision for his program. His future is bright, but remember this is a honeymoon year. No pressure whatsoever. Next year, different story. Let's see how he handles that before we break out the anointing oils, to quote for rather portly ex-Jets coach.
[j e t s] 8:45 pm: Rich, what do you think of the lesser known Jets like Sean Ryan. Do lunch pail guys like him have a future on this team? Love his blocking. I think personnel guys make their money with the smaller moves that turn out well for depth and specials. Secondly, who is the most responsible on special teams for blowing up the wedges that Justin Miller always seems to find?
[RCimini] 8:46 pm: Ryan is a versatily guy, can play TE and H-Back. I don't think he's good enough to say he's part of the future for sure, but he's smart and tough, so that's a good start
[Ikeyman3] 8:46 pm: Who do you think is the Most valuable and who do you think is the Least valuable player on the 2006 Jets? Do you think Mangini's training camp helped reduce the injuries for this season?
[RCimini] 8:48 pm: I agree with Coles as MVP. Would've had Chad a close second. Least valuable? Hmmm. I guess that means biggest disappointments, so I'd have to go with Adrian Jones, Kimo, Barrett, Barlow, Blaylock.
[RMJK] 8:47 pm: Rich,1. who are you predicting to win Jet-Miami and why? 2. Was Nugent worth a #2 draft spot ?
[RCimini] 8:50 pm: Right now, I'm leaning toward Miami over Jets. Reasons: J Taylor. Home field. Harrington not as bad as last week. Fins hate Jets. Nugent? Solid kicker, but not worth a No. 2. You can get guys like that off the street.
[RMJK] 8:50 pm: thanks
[Nocomment] 8:50 pm: Rich: You said there's talk of some interest in Michael Turner of San Diego. How well do you think Turner can fit into the game plan--currently they rotate backs pretty heavily. While this tactic has worked to some extent, it doesn't allow a featured back to gain steam and improve as the game goes on. Turner strikes me as a featured back type of player. If they Mangini grabs Turner, and plans on still having a rotating backfield, how effective can Turner be?
[RCimini] 8:51 pm: If the Jets get Turner, believe me, Mangini won't be rotating his backs nearly as much. This team needs a No. 1 back. The committee deal only gets you so far.
[freestater] 8:51 pm: We hear alot of static about Jon Vilma's stats taking a dive in the 3-4, but he seems to lead the defense. How important has Johnathan been in Kerry Rhodes development?
[RCimini] 8:52 pm: JV has been a positive influence on Kerry. They watch film together 3 nights a week at each other's house. JV hasn't made any impact plays, but you can't write him off. he's a good player and he'll be better next year.
[Jets Babe] 8:53 pm: i cant believe that cimini is taking th fins over the jets :o
[VUJetsFan] 8:53 pm:
[VUJetsFan] 8:44 pm: Looking ahead, haha, if the jets get in the playoffs which team do you feel the jets match up well against?
[RCimini] 8:53 pm: sorry, babe, just a gut feeling.
[freestater] 8:53 pm: thanks, Rich
[freestater] 8:54 pm: for the answer... not the Miami pick, ya bastid!
[RCimini] 8:55 pm: They match up well against the Patriots, obviously. That would be a classic. If they get Balt, it could be a long day. Balt pressures the QB and would shut down the Jets passing game. Not a good matchup.
[SAR I] 8:55 pm: Rich: Now that the Jets have cheerleaders, what became of the flagboys? Is it true that the flagboys gave Serby back rubs and get caught and fired and replaced to avoid a scandal?
[SAR I] 8:55 pm: .....just kidding......
[SAR I] 8:55 pm: The real question.....
[Rich - ® ©] 8:56 pm: Now that is the Scott that we all remember....
[SAR I] 8:56 pm: Is Sutton running the D or is it really Mangini since the Cleveland game?
[RCimini] 8:56 pm: How'd you hear the Serby story? Didn't think that would get out. LOL.
[SAR I] 8:56 pm: I won't tell.
[SAR I] 8:56 pm: Is Sutton running the D or is it really Mangini since the Cleveland game?
[RCimini] 8:57 pm: Bob still is calling the defensive plays. Eric is on the phone with him, so he obviously has input, but Sutton has the calls.
[Queens Jet Fan] 8:57 pm: Just talking about arm strength how would you compare the pre-surgical Pennington to the Pennington of today?
[THE_SOOTHSAYER] 8:58 pm: CV40 will close us out and then I'm sure Rich has to tuck his kids in.
[RCimini] 8:59 pm: Wow, tough question. I wish I saved tapes from 02. I don't think there's a noticeable difference in arm strength, but I think now he needs more torque from his legs and midsection to get the ball where he wants it to go. If he can't step into a throw, it will sail. Maybe, in '02, he didn't have to do that as much.
[CV 40] 9:00 pm: Hey Rich, In my view if the Jets win this game they will basically be in the playoffs. Obviously, a win against Oakland and alittle help is needed, but I believe that if the Jets win it is 90% Jets will be in it. Do you agree?
[RCimini] 9:02 pm: I think Jax will beat NE. If the Jets win in Miami, it means they have to root for Herm to beat Jax. Wouldn't that be a kick? Obviously, I don't think the jets would have much trouble with Oakland, which couldn't score against Stony Brook U.
[Rich - ® ©] 9:02 pm: Is there any chance NE lose both @ Jax and @ TN to close the season?
[THE_SOOTHSAYER] 9:03 pm: Rich, score Sunday?
[RCimini] 9:04 pm: OK, Sooth, a prediction: I know this isn't going to be popular, but I think Miami will win a thriller, say, 21-17. Don't call me Mr. Negative, because, believe it or not, I've picked the Jets for several weeks in a row. Of course, I'd like to see them win because that would be the better story and, as you may know, sports writers are selfish. We always root for the best story.
[freestater] 9:04 pm: dam roofies...
[THE_SOOTHSAYER] 9:04 pm: Fair enough
[meatboy] 9:04 pm: Dolphins are going down baby!
[THE_SOOTHSAYER] 9:04 pm: Everyone please give Rich big thanks for taking time out to spend with us during this busy holiday time. Great job! Come back soon!
[SAR I] 9:04 pm: THANKS RICH
[freestater] 9:05 pm: Thanks, Mr. Cimini
[Nocomment] 9:05 pm: Thanks, Rich, for your time.
[WestCoastOffensive] 9:05 pm: THANKS BUBBA
[SAR I] 9:05 pm: Been a loyal reader for 15+ years. Have a great holiday. Watch your back around Serby.
[RMJK] 9:05 pm: Rich thanks for your honesty
[freestater] 9:05 pm: Jets 27, Mia- 13
[joekool2] 9:05 pm: Thanks Rich
[ChadLover] 9:05 pm: Thanks Rich
[CV 40] 9:05 pm: Thanks
[freestater] 9:05 pm: thank YOu too, sooth
[RCimini] 9:05 pm: Just wanted to thanks you guys and gals for a good time. You're all very passionate fans, and you gotta respect that. I loved all your captions with the Sesame Street photo. Funny stuff. You guys should be writers. God bless, happy holidays.


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People Following Relampagus - 6 See all
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briancajero Wednesday, June 27, 2012
hey thanks for the like b not my usual of mixes .mix was for some one glad you like peace cajero ...
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DJ FROM THE SOUTH Friday, September 02, 2011
i Thank U Very Much =)