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Most Cited Respiratory Physiology & Neurobiology Articles
The most cited articles published since 2011, extracted from Scopus.
Structure and function of ionocytes in the freshwater fish gillAgnieszka K. Dymowska | Pung Pung Hwang | Greg G. Goss
Volume 184, Issue 3, December 2012, Pages 282-292
Freshwater fishes lose ions to the external medium owing to the steep concentration gradients between the body fluids and the water. To maintain homeostasis, they use ionocytes to actively extract Na+, Cl-, and Ca2+ from the dilute external medium and excrete acidic (H+) or basic (HCO3-) equivalents by specialized cells termed ionocytes that are responsible for transport of ions. Freshwater fishes have evolved diverse approaches to solving these similar ionic and acid-base problems. In the few well-studied species, there are clearly different patterns in the physiology and morphology for ionocytes in the gill. In this review, we describe the varying nomenclature of ionocytes that have been used in the past 80 years to allow direct comparison of ionocytes and their common functions in different species. We focus on the recent advancement in our understanding of the molecular mechanisms of ion and acid-base regulation as represented by ionocyte subtypes found in rainbow trout, killifish, tilapia and zebrafish gill. © 2012 Elsevier B.V.
Humans at high altitude: Hypoxia and fetal growthLorna G. Moore | Shelton M. Charles | Colleen G. Julian
Volume 178, Issue 1, August 2011, Pages 181-190
High-altitude studies offer insight into the evolutionary processes and physiological mechanisms affecting the early phases of the human lifespan. Chronic hypoxia slows fetal growth and reduces the pregnancy-associated rise in uterine artery (UA) blood flow. Multigenerational vs. shorter-term high-altitude residents are protected from the altitude-associated reductions in UA flow and fetal growth. Presently unknown is whether this fetal-growth protection is due to the greater delivery or metabolism of oxygen, glucose or other substrates or to other considerations such as mechanical factors protecting fragile fetal villi, the creation of a reserve protecting against ischemia/reperfusion injury, or improved placental O 2 transfer as the result of narrowing the A-V O 2 difference and raising uterine PvO2. Placental growth and development appear to be normal or modified at high altitude in ways likely to benefit diffusion. Much remains to be learned concerning the effects of chronic hypoxia on embryonic development. Further research is required for identifying the fetoplacental and maternal mechanisms responsible for transforming the maternal vasculature and regulating UA blood flow and fetal growth. Genomic as well as epigenetic studies are opening new avenues of investigation that can yield insights into the basic pathways and evolutionary processes involved. © 2011 Elsevier B.V.
New insights into gill ionocyte and ion transporter function in euryhaline and diadromous fishJunya Hiroi | Stephen D. McCormick
Volume 184, Issue 3, December 2012, Pages 257-268
Teleost fishes are able to acclimatize to seawater by secreting excess NaCl by means of specialized " ionocytes" in the gill epithelium. Antibodies against Na+/K+-ATPase (NKA) have been used since 1996 as a marker for identifying branchial ionocytes. Immunohistochemistry of NKA by itself and in combination with Na+/K+/2Cl- cotransporter and CFTR Cl- channel provided convincing evidence that ionocytes are functional during seawater acclimation, and also revealed morphological variations in ionocytes among teleost species. Recent development of antibodies to freshwater- and seawater-specific isoforms of the NKA alpha-subunit has allowed functional distinction of ion absorptive and secretory ionocytes in Atlantic salmon. Cutaneous ionocytes of tilapia embryos serve as a model for branchial ionocytes, allowing identification of 4 types: two involved in ion uptake, one responsible for salt secretion and one with unknown function. Combining molecular genetics, advanced imaging techniques and immunohistochemistry will rapidly advance our understanding of both the unity and diversity of ionocyte function and regulation in fish osmoregulation. © 2012 Elsevier B.V.
Effects of venous compression of the legs on overnight rostral fluid shift and obstructive sleep apneaStefania Redolfi | Isabelle Arnulf | Michel Pottier | T. Douglas Bradley | Thomas Similowski
Volume 175, Issue 3, March 2011, Pages 390-393
The amount of fluid displaced overnight from the legs into the neck as a consequence of lying recumbent correlates with the number of apneas and hypopneas per hour of sleep (AHI). Sedentary living promotes dependent fluid accumulation in the legs that can be counteracted by venous compression of the legs (compression stockings). We hypothesized that, in non-obese sedentary men with obstructive sleep apnea (OSA), wearing compression stockings during daytime will reduce the AHI by reducing the amount of fluid available for the displacement into the neck overnight. Polysomnography and measurement of overnight changes in leg fluid volume and neck circumference were performed at baseline and after one day of legs venous compression. The median AHI decreased from 30.9 (interquartile range 19.6-60.4) to 23.4 (12.9-31.8) (P= 0.016) in association with a median 40% reduction in the change in leg fluid volume (P= 0.016) and a median 42% reduction in the increase in neck circumference (P= 0.016). These results provide proof-of-principle that overnight fluid displacement into the neck plays a causative role in OSA. © 2011 Elsevier B.V.
Measuring the respiratory chemoreflexes in humansJ. Duffin
Volume 177, Issue 2, July 2011, Pages 71-79
Breathing responds to changes in CO2 and O2 detected by respiratory chemoreceptors. In this paper I examine the methodologies for a quantitative assessment of the respiratory chemoreflex characteristics in humans. My intention is to provide the investigator unfamiliar with these methods an overview and introduction that allows them to choose the methodology that answers their needs. Included are brief background histories of such testing techniques and the way in which they have been refined and improved over time, a description of current techniques and tips for their implementation, and a comparative assessment of their relative strengths and weaknesses. I begin with a statement of the problem that provides a brief review of the chemoreflex control of breathing, and difficulties in measuring the chemoreflex characteristics. Then each of the two major methodologies, steady-state and rebreathing techniques are described in detail. Lastly, I compare and contrast these two methodologies. © 2011 Elsevier B.V.
Tight junctions, tight junction proteins and paracellular permeability across the gill epithelium of fishes: A reviewHelen Chasiotis | Dennis Kolosov | Phuong Bui | Scott P. Kelly
Volume 184, Issue 3, December 2012, Pages 269-281
Paracellular permeability characteristics of the fish gill epithelium are broadly accepted to play a key role in piscine salt and water balance. This is typically associated with differences between gill epithelia of teleost fishes residing in seawater versus those in freshwater. In the former, the gill is 'leaky' to facilitate Na+ secretion and in the latter, the gill is 'tight' to limit passive ion loss. However, studies in freshwater fishes also suggest that varying epithelial 'tightness' can impact ionoregulatory homeostasis. Paracellular permeability of vertebrate epithelia is largely controlled by the tight junction (TJ) complex, and the fish gill is no exception. In turn, the TJ complex is composed of TJ proteins, the abundance and properties of which determine the magnitude of paracellular solute movement. This review provides consolidated information on TJs in fish gills and summarizes recent progress in research that seeks to understand the molecular composition of fish gill TJ complexes and what environmental and systemic factors influence those components. © 2012 Elsevier B.V.
Evolutionary and comparative aspects of nitric oxide, carbon monoxide and hydrogen sulfideKenneth R. Olson | John A. Donald | Ryan A. Dombkowski | Steve F. Perry
Volume 184, Issue 2, November 2012, Pages 117-129
The concept that non-respiratory gases, such as nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) functioned as signaling moieties is a relatively recent development, due in part to their ephemeral existence in biological tissues. However, from an evolutionary perspective these gases dominated the prebiotic and anoxic Earth and were major contributors to the origin of life and the advent of eukaryotic animals. As Earth's oxygen levels rose, NO, CO and H2S disappeared from the environment and cells began to utilize their now well-developed metabolic pathways to compartmentalize and regulate these three gases for signaling purposes. Ironically, many of the signaling pathways have become now intimately involved in regulating oxygen delivery and their evolution has continued well into the vertebrates. This review examines the role NO, CO and H2S played in early life and their regulatory roles in oxygen delivery during the course of vertebrate evolution. © 2012 Elsevier B.V.
Cigarette smoking and inflammation revisitedOren Rom | Katia Avezov | Dror Aizenbud | Abraham Z. Reznick
Volume 187, Issue 1, June 2013, Pages 5-10
Despite the significant health risks resulting from tobacco use, the prevalence of smokers worldwide remains high. Cigarette smoking is one of the major sources of toxic chemical exposure to humans and is the greatest cause of preventable illnesses and premature death. The adverse consequences of smoking in various pathologies are mediated by its effects on the immune-inflammatory system. In this review, we aim to explore the effects of cigarette smoking on the inflammatory response and molecular mechanisms with emphasis on the nuclear factor kappa B (NF-kB) pathway. The effects of smoking on various inflammatory pathologies will be discussed, focusing on oral diseases, airway inflammation, chronic obstructive pulmonary disease (COPD) and inflammatory bowel diseases (IBD). © 2013 Elsevier B.V.
Bronchodilation of umeclidinium, a new long-acting muscarinic antagonist, in COPD patientsMarc Decramer | François Maltais | Gregory Feldman | Jean Brooks | Stephanie Harris | Rashmi Mehta | Glenn Crater
Volume 185, Issue 2, January 2013, Pages 393-399
Background: This study evaluated the dose-response of the new long-acting muscarinic antagonist umeclidinium (GSK573719) in patients with COPD. Methods: This randomized, double-blind, placebo-controlled, parallel-group study evaluated three once-daily doses of umeclidinium (125, 250 and 500μg) for 28days in 285 patients with COPD having FEV1 of 35-70% predicted (mean (SD) age=61.4 (8.41); mean (SD) post-bronchodilator FEV1=1.577 (0.450)). The primary endpoint was morning trough FEV1 at Day 29. Secondary endpoints included 0-6h weighted mean FEV1 and serial FEV1 measured over 6h post-dose and at trough. Safety and pharmacokinetics were also assessed. Results: All doses of umeclidinium significantly increased trough FEV1 over placebo from 150 to 168mL (p<0.001), 0-6h weighted mean FEV1 from 113 to 211mL (p<0.001), and serial FEV1 at each point in time over 24h. Reductions in salbutamol use and improvements in FVC were noted for all doses. Umeclidinium was well tolerated with no apparent treatment-related changes in vital signs. Conclusion: Once-daily umeclidinium provides clinically significant, sustained improvement in lung function and is well tolerated. © 2012 Elsevier B.V.
Phrenic motor unit recruitment during ventilatory and non-ventilatory behaviorsCarlos B. Mantilla | Gary C. Sieck
Volume 179, Issue 1, October 2011, Pages 57-63
Phrenic motoneurons are located in the cervical spinal cord and innervate the diaphragm muscle, the main inspiratory muscle in mammals. Similar to other skeletal muscles, phrenic motoneurons and diaphragm muscle fibers form motor units which are the final element of neuromotor control. In addition to their role in sustaining ventilation, phrenic motor units are active in other non-ventilatory behaviors important for airway clearance such as coughing or sneezing. Diaphragm muscle fibers comprise all fiber types and are commonly classified based on expression of contractile proteins including myosin heavy chain isoforms. Although there are differences in contractile and fatigue properties across motor units, there is a matching of properties for the motor neuron and muscle fibers within a motor unit. Motor units are generally recruited in order such that fatigue-resistant motor units are recruited earlier and more often than more fatigable motor units. Thus, in sustaining ventilation, fatigue-resistant motor units are likely required. Based on a series of studies in cats, hamsters and rats, an orderly model of motor unit recruitment was proposed that takes into consideration the maximum forces generated by single type-identified diaphragm muscle fibers as well as the proportion of the different motor unit types. Using this model, eupnea can be accomplished by activation of only slow-twitch diaphragm motor units and only a subset of fast-twitch, fatigue-resistant units. Activation of fast-twitch fatigable motor units only becomes necessary when accomplishing tasks that require greater force generation by the diaphragm muscle, e.g., sneezing and coughing. © 2011 Elsevier B.V.
Obstructive sleep apnea and inflammation: Relationship to cardiovascular co-morbidityBrian D. Kent | Silke Ryan | Walter T. McNicholas
Volume 178, Issue 3, September 2011, Pages 475-481
Obstructive sleep apnoea syndrome (OSAS) is a highly prevalent disease and associated with cardiovascular morbidity and mortality. The pathogenesis of cardiovascular complications in OSAS is incompletely understood but a multifactorial etiology is likely. There is emerging evidence that inflammatory processes leading to endothelial dysfunction play a pivotal role. Various studies have demonstrated elevated inflammatory markers in OSAS patients in comparison to matched control subjects with a significant fall after effective treatment with continuous positive airway pressure. Cell culture and animal studies have significantly enhanced our understanding of the mechanisms of inflammation in OSAS. Intermittent hypoxia, the hallmark feature of OSAS, leads to a preferential activation of inflammatory pathways with the downstream consequence of expression of pro-inflammatory cytokines, chemokines and adhesion molecules that may contribute to endothelial dysfunction. Further studies are required to determine the precise role of inflammation in the cardiovascular pathogenesis of OSAS, particularly its interaction with oxidative stress, obesity and metabolic dysfunction. © 2011 Elsevier B.V.
Seven things fish know about ammonia and we don'tPatricia A. Wright | Chris M. Wood
Volume 184, Issue 3, December 2012, Pages 231-240
In this review we pose the following seven questions related to ammonia and fish that represent gaps in our knowledge. 1. How is ammonia excretion linked to sodium uptake in freshwater fish? 2. How much does branchial ammonia excretion in seawater teleosts depend on Rhesus (Rh) glycoprotein-mediated NH3 diffusion? 3. How do fish maintain ammonia excretion rates if branchial surface area is reduced or compromised? 4. Why does high environmental ammonia change the transepithelial potential across the gills? 5. Does high environmental ammonia increase gill surface area in ammonia tolerant fish but decrease gill surface area in ammonia intolerant fish? 6. How does ammonia contribute to ventilatory control? 7. What do Rh proteins do when they are not transporting ammonia? Mini reviews on each topic, which are able to present only partial answers to each question at present, are followed by further questions and/or suggestions for research approaches targeted to uncover answers. © 2012 Elsevier B.V.
Oxygenation of the placental-fetal unit in humansHenning Schneider
Volume 178, Issue 1, August 2011, Pages 51-58
This review focuses on the role of oxygen and the changes in oxygen levels in the different trimesters of pregnancy in the human placenta. In the first trimester, the physiological conversion of the spiral arteries restricts maternal blood flow into the intervillous space creating a low oxygen environment for the trophoblast and the embryo. In the second trimester, progressive conversion of the spiral arteries allows unhindered entrance of maternal blood into the intervillous space. In early pregnancy, pathology of spiral artery conversion may promote premature flow of maternal blood resulting in miscarriage. In more advanced pregnancy, incomplete conversion of spiral arteries impairs maternal blood flow to the placenta, causing chronic hypoxia and growth restriction of the fetus. Chronically reduced maternal supply of oxygen to the placental-fetal unit may be partially balanced by metabolic reprogramming of the placenta. Acute impairment of oxygenation in the perinatal period and its effect on the placental-fetal unit will also be discussed. © 2011 Elsevier B.V.
Inflammatory pathways in children with insufficient or disordered sleepJinkwan Kim | Fahed Hakim | Leila Kheirandish-Gozal | David Gozal
Volume 178, Issue 3, September 2011, Pages 465-474
Sleep is not only an essential physiological function, but also serves important roles in promoting growth, maturation, and overall health of children and adolescents. There is increasing interest regarding the impact of sleep and its disorders on the regulation of inflammatory processes and end-organ morbidities, particularly in the context of metabolic and cardiovascular diseases (CVD) and their complications. Obstructive sleep apnea syndrome (OSAS) is an increasingly common health problem in children, and in the last decade, the emergence of increasing obesity rates has further led to remarkable increases in the prevalence of OSAS, along with more prominent neurocognitive, behavioral, cardiovascular and metabolic morbidities. Although the underlying mechanisms leading to OSAS-induced morbidities are likely multi-factorial, and remain to be fully elucidated, activation of inflammatory pathways by OSAS has emerged as an important pathophysiological component of the end-organ injury associated with this disorder. To this effect, it would appear that OSAS could be viewed as a chronic, low-grade inflammatory disorder. Furthermore, the concurrent presence of obesity and OSAS poses a theoretically increased risk of OSAS-related complications. In this review, we will critically review the current state of research regarding the impact of insufficient and disrupted sleep and OSAS on the immune processes and inflammatory pathways that underlie childhood OSAS as a distinctive systemic inflammatory condition in children, and will explore potential interactions between OSAS and obesity. © 2011 Elsevier B.V.
Sex differences in exertional dyspnea in patients with mild COPD: Physiological mechanismsJordan A. Guenette | Dennis Jensen | Katherine A. Webb | Dror Ofir | Natya Raghavan | Denis E. O'Donnell
Volume 177, Issue 3, August 2011, Pages 218-227
The purpose of this study was to evaluate the physiological basis for sex-differences in exercise-induced dyspnea in patients with mild COPD. We compared operating lung volumes, breathing pattern and dyspnea during incremental cycling in 32 men (FEV1=86±10% predicted) and women (FEV1=86±12% predicted) with mild COPD and 32 age-matched controls. There were no sex differences in dyspnea in the control group at any work-rate or ventilation (V̇E). Women with COPD had significantly greater dyspnea than men at 60 and 80W. At 80W, dyspnea ratings were 5.7±2.3 and 3.3±2.5Borg units (P<0.05) and the V̇E to maximal ventilatory capacity ratio was 72% and 55% in women and men, respectively (P<0.05). Comparable increases in dynamic hyperinflation were seen in both male and female COPD groups at symptom limitation but women reached tidal volume constraints at a lower work rate and V̇E than men. Superimposing mild COPD on the normal aging effects had greater sensory consequences in women because of their naturally reduced ventilatory reserve. © 2011 Elsevier B.V.
Experimental protocols and preparations to study respiratory long term facilitationJason H. Mateika | Kulraj S. Sandhu
Volume 176, Issues 1-2, April 2011, Pages 1-11
Respiratory long-term facilitation is a form of neuronal plasticity that is induced following exposure to intermittent hypoxia. Long-term facilitation is characterized by a progressive increase in respiratory motor output during normoxic periods that separate hypoxic episodes and by a sustained elevation in respiratory activity for up to 90 min after exposure to intermittent hypoxia. This phenomenon is associated with increases in phrenic, hypoglossal or carotid sinus nerve inspiratory-modulated discharge. The examination of long-term facilitation has been steadily ongoing for approximately 3 decades. During this period of time a variety of animal models (e.g. cats, rats and humans), experimental preparations and intermittent hypoxia protocols have been used to study long-term facilitation. This review is designed to summarize the strengths and weaknesses of the models, preparations and protocols that have been used to study LTF over the past 30 years. The review is divided into two primary sections. Initially, the models and protocols used to study LTF in animals other than humans will be discussed, followed by a section specifically focused on human studies. Each section will begin with a discussion of various factors that must be considered when selecting an experimental preparation and intermittent hypoxia protocol to examine LTF. Model and protocol design recommendations will follow, with the goal of presenting a prevailing model and protocol that will ultimately ensure standardized comparisons across studies. © 2011.
Intermittent hypoxia increases melanoma metastasis to the lung in a mouse model of sleep apneaIsaac Almendros | Josep M. Montserrat | Marta Torres | Mireia Dalmases | Maria L. Cabañas | Francisco Campos-Rodríguez | Daniel Navajas | Ramon Farré
Volume 186, Issue 3, May 2013, Pages 303-307
Obstructive sleep apnea (OSA) has recently been associated with an increased risk of cancer incidence and mortality in humans. Experimental data in mice have also shown that intermittent hypoxia similar to that observed in OSA patients enhances tumor growth. The aim of this study was to test the hypothesis that intermittent hypoxia mimicking OSA enhances lung metastasis. A total of 75 C57BL/6J male mice (10-week-old) were subjected to either spontaneous or induced melanoma lung metastasis. Normoxic animals breathed room air and intermittent hypoxic animals were subjected to cycles of 20s of 5% O2 followed by 40s of room air for 6h/day. Spontaneous and induced lung metastases were studied after subcutaneous and intravenous injection of B16F10 melanoma cells, respectively. Compared with normoxia, intermittent hypoxia induced a significant increase in melanoma lung metastasis. These animal model results suggest that intermittent hypoxia could contribute to cancer metastasis in patients with OSA. © 2013 Elsevier B.V.
Sensing pulmonary oxidative stress by lung vagal afferentsThomas E. Taylor-Clark | Bradley J. Undem
Volume 178, Issue 3, September 2011, Pages 406-413
Oxidative stress in the bronchopulmonary airways can occur through a variety of inflammatory mechanisms and also following the inhalation of environmental pollutants. Oxidative stress causes cellular dysfunction and thus mammals (including humans) have developed mechanisms for detecting oxidative stress, such that defensive behavior and defensive biological mechanisms can be induced to lessen its potential damage. Vagal sensory nerves innervating the airways play a critical role in the detection of the microenvironment in the airways. Oxidative stress and associated compounds activate unmyelinated bronchopulmonary C-fibers, initiating action potentials in these nerves that conduct centrally to evoke unpleasant sensations (e.g. urge to cough, dyspnea, chest-tightness) and to stimulate/modulate reflexes (e.g. cough, bronchoconstriction, respiratory rate, inspiratory drive). This review will summarize the published evidence regarding the mechanisms by which oxidative stress, reactive oxygen species, environmental pollutants and lipid products of peroxidation activate bronchopulmonary C-fibers. Evidence suggests a key role for transient receptor potential ankyrin 1 (TRPA1), although transient receptor potential vanilloid 1 (TRPV1) and purinergic P2X channels may also play a role. Knowledge of these pathways greatly aids our understanding of the role of oxidative stress in health and disease and represents novel therapeutic targets for diseases of the airways. © 2011 Elsevier B.V.
Breathing challenges in Rett Syndrome: Lessons learned from humans and animal modelsJan Marino Ramirez | Christopher Scott Ward | Jeffrey Lorenz Neul
Volume 189, Issue 2, November 2013, Pages 280-287
Breathing disturbances are a major challenge in Rett Syndrome (RTT). These disturbances are more pronounced during wakefulness; but irregular breathing occurs also during sleep. During the day patients can exhibit alternating bouts of hypoventilation and irregular hyperventilation. But there is significant individual variability in severity, onset, duration and type of breathing disturbances. Research in mouse models of RTT suggests that different areas in the ventrolateral medulla and pons give rise to different aspects of this breathing disorder. Pre-clinical experiments in mouse models that target different neuromodulatory and neurotransmitter receptors and MeCP2 function within glia cells can partly reverse breathing abnormalities. The success in animal models raises optimism that one day it will be possible to control or potentially cure the devastating symptoms also in human patients with RTT. © 2013.
Hydrogen sulfide is an oxygen sensor in the carotid bodyKenneth R. Olson
Volume 179, Issues 2-3, December 2011, Pages 103-110
There is considerable controversy surrounding the initial step that transduces a fall in PO2 into a physiological signal, i.e., the "oxygen sensor" in chemoreceptors. Initial studies on systemic and respiratory vessels suggested that the metabolism of hydrogen sulfide (H 2S) could serve as the oxygen sensor. This model was subsequently extended to chemoreceptors in fish and tissues of other animals. In this model, constitutive production of biologically active H 2S is offset by H 2S oxidation; when oxygen availability falls, production of H 2S exceeds metabolism, and the resultant increase in intracellular H 2S initiates the appropriate physiological responses. This model is supported by observations that the effects of hypoxia and H 2S are similar, if not identical in many tissues: hypoxic responses are inhibited by inhibitors of H 2S biosynthesis and augmented by sulfur donating molecules, and the tipping point between H 2S production and oxidation occurs at physiologically relevant PO2s. Recent studies from other laboratories support this mechanism of O 2 sensing in the carotid body. This review summarizes information that supports the H 2S metabolic hypothesis in these tissues with emphasis on the carotid chemoreceptors. Evidence suggesting that H 2S is not involved in oxygen sensing in the carotid body is also critically evaluated. © 2011 Elsevier B.V.
Altered ventilatory and thermoregulatory control in male and female adult Pet-1 null miceMatthew R. Hodges | Simon Best | George B. Richerson
Volume 177, Issue 2, July 2011, Pages 133-140
The integrity of the serotonin (5-HT) system is essential to normal respiratory and thermoregulatory control. Male and female transgenic mice lacking central 5-HT neurons (Lmx1bf/f/p mice) show a 50% reduction in the hypercapnic ventilatory response and insufficient heat generation when cooled (Hodges and Richerson, 2008a; Hodges et al., 2008b). Lmx1bf/f/p mice also show reduced body temperatures (Tbody) and O2 consumption V̇O2, and breathe less at rest and during hypoxia and hypercapnia when measured below thermoneutrality (24°C), suggesting a role for 5-HT neurons in integrating ventilatory, thermal and metabolic control. Here, the hypothesis that Pet-1 null mice, which retain 30% of central 5-HT neurons, will demonstrate similar deficits in temperature and ventilatory control was tested. Pet-1 null mice had fewer medullary tryptophan hydroxylase-immunoreactive (TPH+) neurons compared to wild type (WT) mice, particularly in the midline raphé. Female (but not male) Pet-1 null mice had lower baseline ventilation (V̇E), breathing frequency (f), V̇O2 and Tbody relative to female WT mice (P<0.05). In addition, V̇E and V̇E/V̇O2 were decreased in male and female Pet-1 null mice during hypoxia and hypercapnia (P<0.05), but only male Pet-1 null mice showed a significant deficit in the hypercapnic ventilatory response when expressed as % of control (P<0.05). Finally, male and female Pet-1 null mice showed significant decreases in Tbody when externally cooled to 4°C. These data demonstrate that a moderate loss of 5-HT neurons leads to a modest attenuation of mechanisms defending body temperature, and that there are gender differences in the contributions of 5-HT neurons to ventilatory and thermoregulatory control. © 2011 Elsevier B.V.
Contributions of vascular inflammation in the brainstem for neurogenic hypertensionHidefumi Waki | Sabine S. Gouraud | Masanobu Maeda | Mohan K. Raizada | Julian F R Paton
Volume 178, Issue 3, September 2011, Pages 422-428
Essential hypertension is idiopathic although it is accepted as a complex polygenic trait with underlying genetic components, which remain unknown. Our supposition is that primary hypertension involves activation of the sympathetic nervous system. One pivotal region controlling arterial pressure set point is nucleus tractus solitarii (NTS). We recently identified that pro-inflammatory molecules, such as junctional adhesion molecule-1, were over expressed in endothelial cells of the microvasculature supplying the NTS in an animal model of human hypertension (the spontaneously hypertensive rat: SHR) compared to normotensive Wistar Kyoto (WKY) rats. We have also shown endogenous leukocyte accumulation inside capillaries within the NTS of SHR but not WKY rats. Despite the inflammatory state in the NTS of SHR, transcripts of some inflammatory molecules such as chemokine (C-C motif) ligand 5 (Ccl5), and its receptors, chemokine (C-C motif) receptor 1 and 3 were down-regulated in the NTS of SHR compared to WKY rats. This may be compensatory to avoid further strong inflammatory activity. More importantly, we found that down-regulation of Ccl5 in the NTS of SHR may be pro-hypertensive since microinjection of Ccl5 into the NTS of SHR decreased arterial pressure but was less effective in WKY rats. Leukocyte accumulation of the NTS microvasculature may also induce an increase in vascular resistance and hypoperfusion within the NTS; the latter may trigger release of pro-inflammatory molecules which via paracrine signaling may affect central neural cardiovascular activity conducive to neurogenic hypertension. All told, we suggest that vascular inflammation within the brainstem contributes to neurogenic hypertension by multiple pathways. © 2011 Elsevier B.V.
Inflammation and cardiorespiratory control: The role of the vagus nerveJulian F. Thayer | Adrian Loerbroks | Esther M. Sternberg
Volume 178, Issue 3, September 2011, Pages 387-394
Inflammation and immunity have been implicated in a wide variety of diseases and disorders ranging from asthma to cardiovascular disease to hemorrhagic shock. In this review we will briefly consider the evidence for the neural concomitants of immunomodulation. First, we will briefly review the anatomy and physiology of the cardiorespiratory system. Then we will review the anatomy and physiology of neural-immune communication. The nucleus of the solitary tract is a site of integration of both the afferent and efferent neural regulation of the cardiorespiratory as well as the immune system. Then we will provide an overview of what is known about neuroimmunomodulation from both animal and human studies including neuroimaging and clinical studies. Finally, we will discuss a possible role of this neural circuitry in asthma related health disparities. © 2011 Elsevier B.V.
Carbon monoxide (CO) and hydrogen sulfide (H2S) in hypoxic sensing by the carotid bodyNanduri R. Prabhakar
Volume 184, Issue 2, November 2012, Pages 165-169
Carotid bodies are sensory organs for monitoring arterial blood oxygen (O2) levels, and the ensuing reflexes maintain cardio-respiratory homeostasis during hypoxia. This article provides a brief update of the role of carbon monoxide (CO) and hydrogen sulfide (H2S) in hypoxic sensing by the carotid body. Glomus cells, the primary site of O2 sensing in the carotid body express heme oxygenase-2 (HO-2), a CO catalyzing enzyme. HO-2 is a heme containing enzyme and has high affinity for O2. Hypoxia inhibits HO-2 activity and reduces CO generation. Pharmacological and genetic approaches suggest that CO inhibits carotid body sensory activity. Stimulation of carotid body activity by hypoxia may reflect reduced formation of CO. Glomus cells also express cystathionine γ-lyase (CSE), an H2S generating enzyme. Exogenous application of H2S donors, like hypoxia, stimulate the carotid body activity and CSE knockout mice exhibit severely impaired sensory excitation by hypoxia, suggesting that CSE catalyzed H2S is an excitatory gas messenger. Hypoxia increases H2S generation in the carotid body, and this response was attenuated or absent in CSE knockout mice. HO inhibitor increased and CO donor inhibited H2S generation. It is proposed that carotid body response to hypoxia requires interactions between HO-2-CO and CSE-H2S systems. © 2012 Elsevier B.V.
Tanshinone IIA ameliorates seawater exposure-induced lung injury by inhibiting aquaporins (AQP) 1 and AQP5 expression in lungJiahuan Li | Min Xu | Qixin Fan | Xiaoyan Xie | Yong Zhang | Deguang Mu | Pengtao Zhao | Bo Zhang | Fale Cao | Yanxia Wang | Faguang Jin | Zhichao Li
Volume 176, Issues 1-2, April 2011, Pages 39-49
Aquaporins (AQPs), a family of transmembrane water channels, mediate physiological response to changes of fluid volume and osmolarity. It is still unknown what role of AQPs plays in seawater drowning-induced acute lung injury (ALI) and whether pharmacologic modulation of AQPs could alleviate the severity of ALI caused by seawater aspiration. In our study, the results from RT-PCR and Western blotting showed that intratracheal installation of seawater up-regulated the mRNA and protein levels of AQP1 and AQP5 in lung tissues. Furthermore, we found that treatment of tanshinone IIA (TIIA, one of the main active components from Chinese herb Danshen) significantly reduced the elevation of AQP1 and AQP5 expression induced by seawater in rats, A549 cells and primary alveolar type II cells. Treatment of TIIA also improved lung histopathologic changes and blood-gas indices, and reduced lung edema and vascular leakage. These findings demonstrated that AQP1 and AQP5 might play an important role in the development of lung edema and lung injury, and that treatment with TIIA could significantly alleviate seawater exposure-induced ALI, which was probably through the inhibition of AQP1 and AQP5 over-expression in lungs. © 2011 Elsevier B.V.


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2601 Spencer Road
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Smoky Pumpkin Bisque
Mic Check, *tap-tap*, 1, 2, 1, 2.. Is this thing on? Holy crap, people, it's been a hot minute since my last recipe, hasn't it? I can say with certainty that time has totally gotten away from me,… Read More
Posted on February 28, 2013
Warm Smoky Tempeh Salad
As some of you may know, I spend the past weekend (plus a couple of days) in San Francisco. If you've been there before, you can imagine how excited I was about trying out some more vegan restaurants… Read More
Posted on October 12, 2012
Cajun Mac 'n' Cheese
This dish started out with me staring into my crisper drawer at a bag of okra that I've had sitting, neglected, in there for a little too long. I had never cooked it, myself; just enjoyed it… Read More
Updated on July 3, 2012
Grilled Summer Stacks with Smoky Almond Cream
It seems as though, lately, I have been somewhat of a grilling machine. I just can't stop! With this month's love bloghop theme being #tomatolove, I knew right away that the first recipe would involve grilling them; but,… Read More


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Our cleaners are experienced in all types of cleaning jobs, so they're well equipped to handle any challenge that is thrown at them. Our service is also truly local. It's not a nice feeling to discover that your cleaning company comes from many kilometres away. We don't. From Aubin to Atwell, from Success to Grove, we really do know the local area. When you want a home cleaner in Perth, come to us for great service at great prices. We offer a full turnkey service, supplying all the necessary cleaning products. That means that we can get down to work as soon as we arrive, saving you precious time – and we all know that time is money! Call us today.more
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Articles tagged macy gray
15 Jun 2015 // 12:50 PM
New Orleans jam experts Galactic are joined by Macy Gray for a soulful number in the form of "Into the Deep", the title cut off of their forthcoming LP.READ more
21 Aug 2009 // 3:20 AM
The upcoming season of ABC's Dancing with the Stars features two official one-hit wonders and one wannabe.READ more
12 Apr 2007 // 11:00 PM
It's hard to imagine that Macy's lost her mojo already, but after two straight mediocre albums, it definitely appears there's a spark missing.READ more
25 Aug 2006 // 2:00 AM
Percy's a mortician, aware of the ways that bodies can be disfigured and rearranged, how life and death are performances for audiences.READ more
7 Mar 2005 // 1:00 AM
For director Antoine Fuqua, it was clear that the right place to start a concert imagining the history of the blues would start with a song from Africa.READ more
10 Dec 2004 // 1:00 AM
The sensational Buddy Guy is his own, allusive story, as he incarnates a bridge between generations and styles.READ more
1 Nov 2004 // 1:00 AM
'Actually,' Frank Coraci begins his commentary for Around the World in 80 Days, 'I never wanted to do a director's commentary.'"READ more
17 Jun 2004 // 1:00 AM
The absolutely scariest scene in Around the World in 80 Days features Arnold Schwarzenegger.READ more
7 Jun 2004 // 1:00 AM
On screen, Spider-Man necessarily becomes more literal, less imaginative.READ more
23 Oct 2003 // 1:00 AM
Just when you thought the Scary Movie franchise had run out of ideas, here it comes again -- looking like it's run out of ideas.READ more
31 Jul 2003 // 11:00 PM
The wonders of Macy Gray are multifarious. By turns ferocious and vulnerable, seductive and schemey, she appears an artist with range and ambition, not to mention a complex emotional history that informs everything she does.READ more
2 May 2002 // 1:00 AM
Spider-Man doesn't get caught up in its own snazzy special effects.READ more
17 Sep 2001 // 4:00 PM
What Gray possesses is a distinct voice and even more distinct personality that has given her the kind of visibility that she could have never imagined-the gawky brown girl with the squeaky voice has perhaps "queered" our perceptions of "The Diva".READ more
1 Jan 1995 // 1:03 AM
Plausibility is plainly not Training Day's concern. It's more interested in images and ideas than practicalities.READ more
The Midnight Pine "Vice" (video) (premiere) // Music
Kanye West "Fade" (Singles Going Steady) // Music
David Nagler "Chicago" (video) (premiere) // Music
Johnnyswim "Drunks" (audio) (premiere) // Music
Indie Horror Month 2016: Diving into 'Reveal the Deep'
// Moving Pixels
"In Reveal the Deep, the light only makes you more aware of the darknessREAD the article


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Rehersal Dinner/ Day after Brunch
- Last updated on September 2, 2009 at 4:53 am
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- 2 comments
Rehersal Dinner
We will rent out Yuzo, an asian bistro for our rehersal Dinner. Since its a destination wedding and we only have 40 people comming we will have everyone join us. For fun and some grea pictures we will be calling it the black and white dinner where everyone has to wear black and our white.
My Dress
(2) Comments
Where did you get that dress?!?
That dress is amazing!


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The Associated Students of Washington State University attended the meeting to discuss ways that WSU students can be better citizens of Pullman, and how the city can better accommodate students.
Pullman City Council meets with the WSU student government twice a year, and one of the council members is a student at WSU.
"Every other student government has just expressed awe that we sit down and meet with our city council, and so I think that this meeting was excellent." said council member Derrick Skaug.
The first issue discussed was waste management. ASWSU students will be looking into installing more off-campus trash cans, and the city announced that it will be switching to co-mingled recycling at the end of the spring semester.
Public safety was also discussed. Police Chief Gary Jenkins said that crime in Pullman has not significantly increased over the last year, but security cameras will soon be installed in the Adams Mall area.
The students expressed that they would like increased bus service, but city officials said that the options are limited due to the city's tight budget.


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Bonfire on the Beach lights up lakefront with music
Make a list: You'll need a beach towel, a swimsuit, maybe some flip-flops and a party attitude for Bonfire on the Beach.
It may be the opening week of Summerfest, but this party kicks off at 6 p.m. Thursday at Bradford Beach with music from De La Buena. The band plays until 7:30 p.m. when DJ Kid Millions takes the stage, followed by Kane Place Records from 9 to 10 p.m. Bonfire pits will allow party-goers to see each other and keep them warm if the temperatures drop. »Read Full Article
Mac Miller makes sold-out Eagles Ballroom a massive party
There probably isn't a hip-hop show in Milwaukee this year that will offer as much bang for the buck as Mac Miller's concert Saturday night, in front of a sold-out Eagles Ballroom at the Rave.
Aside from the allure of the 21-year-old headliner, the Milwaukee date of Miller's Space Migration tour boasted four supporting acts, two of which — Earl Sweatshirt and Chance the Rapper — are among the most hyped up-and-coming MCs of 2013. »Read Full Article(3)
Looking for a farmers markets? Check out these shopping lists
If it's Saturday morning, it's time to check out farmers markets.
Check out this interactive map of southeast Wisconsin farmers markets, most of which are open Saturday mornings. »Read Full Article


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On Tap Today: It's cold again and there's stuff to do
It's nearly the end of the first month of this brand new year. We're pretty sure that means you can't wish someone "Happy New Year" or fiddle with those resolutions after tomorrow. In any case, it's a good time to offer good wishes and look over those annual goals one last time (if you haven't blown them already).
One of our goals is to be a great source for what's going on. And so let's look at what's on the agenda today. »Read Full Blog Post(2)
'50 Shades of Grey' gets a 'Spank!' spoof at Turner Hall
50 shades of 'Spank!'
It's sultry. It's steamy. And it's not what you think. »Read Full Article
Imagine Dragons delivers powerful show at sold-out Eagles Ballroom
With a short but memorable set at Rock the Green in Veterans Park last September, Las Vegas-based alternative-rock act Imagine Dragons declared itself to anyone watching as an exciting live band on the rise.
Saturday night at the Rave, the band more than delivered on its promise. »Read Full Article
MSO's stunning, wide-ranging look at Rachmaninoff
If the name Rachmaninoff is synonymous with piano concertos for you, you're not alone. You're also missing a big part of the picture.
Friday evening's Milwaukee Symphony Orchestra concert gave a multidimensional look at the pianist/ composer/conductor through his first piano concert, one of his choral/orchestral masterpieces and an orchestral fantasy. »Read Full Article
In Tandem's 'Beast on the Moon' capture's young couple's struggles to move on from painful past
In the first scene of Richard Kalinoski's "Beast on the Moon" - now on stage in a beautiful and nuanced production at In Tandem's Tenth Street Theatre - 19-year-old Aram Tomasian learns that his newly arrived child bride is not the girl he'd been promised.
"I ordered the girl in this picture and they sent me someone else," Aram pouts. Yes, 15-year-old Seta replies, but "I am the same girl who wrote you." Eager to please but also slightly impish, Seta can't resist adding that she is also prettier than the pictured girl. »Read Full Article


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Polk County, Florida Antitrust Lawyers
Find Polk County, Florida Antitrust Attorneys by City
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- Auburndale
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Jonathan C. Koch
Hillsborough County, FL Antitrust Attorney.
(813) 253-8888University of Virginia School of LawMuhlenberg College11th Circuit and FloridaFlorida State Bar
John R. Cole, II
Sarasota County, FL Antitrust Attorney.
The LII Lawyer Directory contains lawyers who have claimed their profiles and are actively seeking clients. Find more Polk County, Florida Antitrust Lawyers in the Justia Legal Services and Lawyers Directory which includes profiles of more than one million lawyers licensed to practice in the United States, in addition to profiles of legal aid, pro bono and legal service organizations.


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In every area of practice, WilmerHale brings the insight, dedication to excellence, and commitment to client service needed for our clients to achieve their business objectives. Our five-department structure and team approach to service enable us to provide the highest level of responsiveness and access to lawyers with the most appropriate experience.
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On May 31, 2011, the Supreme Court clarified the intent requirement for induced infringement under 35 U.S.C. § 271(b), which states that "[w]hoever actively induces infringement of a patent shall be liable as an infringer." Global-Tech Appliances, et al. v. SEB S.A., No. 10-6 (October 12, 2010). The question presented was:
Whether the legal standard for the state of mind element of a claim for actively inducing infringement under 35 U.S.C. § 271(b) is "deliberate indifference of a known risk" that an infringement may occur, as the Court of Appeals for the Federal Circuit held, or "purposeful, culpable expression and conduct" to encourage an infringement, as this Court taught in MGM Studios, Inc. v. Grokster, Ltd., 545 U.S. 913, 937 (2005)?
The case began on August 27, 1999, when SEB sued Montgomery Ward & Co., Inc. ("Montgomery Ward"), Global-Tech Appliances, Inc. ("Global Tech") and Pentalpha Enterprises, Ltd. ("Pentalpha") in the Southern District of New York for infringement of U.S. Patent No. 4,995,312 ("the '312 patent"). The '312 patent is directed to a deep fryer with a well-insulated outer skirt. A jury found that Pentalpha both willfully infringed and induced infringement of claim 1 of the '312 patent and awarded SEB $4.65 million in reasonable royalty. Pentalpha filed post-trial motions on several grounds, most of which the district court denied, except that the court reduced the verdict by $2 million. The district court awarded SEB enhanced damages and attorneys' fees, but later vacated that award in light of In re Seagate Technology, 497 F.3d 1360 (Fed. Cir. 2007), and entered judgment against defendants in the amount of $4,878,341. SEB S.A. v. Montgomery Ward & Co., No. 99-9284 (S.D.N.Y. Oct. 3, 2008). On October 30, 2008, Pentalpha appealed to the U.S. Court of Appeals for the Federal Circuit, asserting errors by the district court relating to the jury verdict and several post-trial rulings. SEB cross-appealed and sought enhanced damages.
On February 5, 2010, the Federal Circuit affirmed the district court decision and further held that "deliberate indifference" as to whether a product might infringe a patent can satisfy the state of mind element for actively inducing infringement. SEB S.A. v. Montgomery Ward & Co., Inc., 594 F.3d 1360 (Fed. Cir. 2010). The court held that "a claim for inducement is viable even where the patentee has not produced direct evidence that the accused infringer actually knew of the patent-in-suit." Id. at 1377 (emphasis added). The court stated that "deliberate indifference of a known risk is not different from actual knowledge, but is a form of actual knowledge." Id. In this case "[t]he record contain[ed] adequate evidence to support a conclusion that Pentalpha deliberately disregarded a known risk that SEB had a protective patent." Id. The Court focused on Pentalpha's purchasing and copying an SEB deep fryer, and failing to inform the counsel who prepared a "right-to-use study" of the copying. Id.
In the May 31, 2011 opinion by Justice Alito, the Supreme Court affirmed (8-1) the judgment against Global-Tech, but rejected the Federal Circuit's reasoning. Raising the standard for finding induced infringement under § 271(b), the Court rejected the Federal Circuit's standard that allowed liability where there is deliberate indifference to a known risk of infringement. Instead, the Court found that induced infringement under § 271(b) requires knowledge that the induced acts constitute patent infringement. Relying on Aro Mfg. Co. v. Convertible Top Replacement Co., 377 U. S. 476 (1964), in which the Supreme Court held that a violator of § 271(c) must know "that the combination for which his component was especially designed was both patented and infringing," the Court held that a similar knowledge requirement applies to inducement under § 271(b).
The Court upheld the Federal Circuit's judgment of induced infringement, concluding that there was sufficient evidence to support a finding of knowledge under the doctrine of willful blindness. (Slip op., pp. 13-14). Specifically, the Court noted that Pentalpha believed that SEB's fryer embodied technology that would be valuable in the U.S. market based on its decision to copy all but the fryer's cosmetic features. The Court found revealing that Pentalpha copied an overseas model of SEB's fryer, aware that it would not bear U.S. patent markings. The Court also found telling that Pentalpha decided not to inform its attorney that the product to be evaluated was "simply a knockoff of SEB's fryer." Taken together, the Court found sufficient evidence for a jury to find that Pentalpha subjectively believed there was a "high probability" that SEB's fryer was patented and took "deliberate steps to avoid knowing that fact," therefore willfully blinding itself to the infringing nature of Sunbeam's sales. (Slip Op., pp. 14-16).
Justice Kennedy dissented. He concurred with the Court's finding that § 271(b) must be read in tandem with § 271(c), and that therefore, to induce infringement a defendant must know that the induced acts constitute patent infringement. However, Justice Kennedy found the Court mistaken in holding that willful blindness will suffice to show knowledge.
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Craftsman Professional All-In-One Cutting System Kit with 4 Attachments plus 19 Accessories
Selling features: 5.5 amp motor, 15,000 - 30,000 RPM variable speed dial provides for matching speed to materials and application. Dust sealed switch for long life. Soft-grip on tool body and side assist handle provides added gripping power and comfort. 3-jawed chuck provides on the job versatility with wrenchless bit change. Built-in work light helps illuminate workpiece.
Includes a Circle Cutter attachment for cutting circles 3-1/2 to 12-inches, Jigsaw handle attachment for precision cutting, Flex shaft attachment with 12 accessories for finger tip control, Right angle attachment with 2 metal cutting and 1 masonry cutting wheels for cutting and trimming brick, tile metal and more, 2 drywall bits and 2 multipurpose bit accessories plus a canvas carrying/storage bag.


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+Tau-Mu Yi Mozilla desperately needs a foothold in mobile. It's possible that even if its project is a complete flop, it will nudge the powers in the right direction or become useful as a rhetorical point showing the flaws of the current system. I'll be pretty surprised if this achieves much commercial success, though.
Stephen ShanklandShared publicly -
A thorough look at +Mozilla Firefox OS and its prospects by +Seth Rosenblatt. Plus bonus photo gallery.
I believe Mozilla has more chances than other players like RIM and Jolly. It's a different approach, that focus on web apps. I live in Brazil and we have a lot of people without access to high quality smartphones. There are a lot of potential around the world. Let's give them a chance.
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HourlyHours to be determined
We are willing to hire a Project Manager for MS SQL BI project who could guide our team of local developers. We are already having a team of 6 developers working on the assignment.
The primary responsibilities for this job are.
1. Candidate must be very technical expert in MS SQL Business intelligence, so he/she be able to find the root cause of any issues.
2. Must have good command over English.
3. Must be self starter and could motivate others.
More information will share with the right candidate during the interview.
Activity on this Job
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Hired: 1
About the Client
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Jobs Posted
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Total Spent
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Avg Hourly Rate Paid
72 Hours


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Netgear NTV200S NeoTV Pro Streaming Player - 1080p HD Streaming, Built-in Wireless-N, HDMI Video Output, 5.1 Surround Sound, Remote ControlItem#: N100-3075 | Model#: NTV200S
Currently Out Of Stock!
You May Consider This Alternative
Netgear NeoTV Pro Streaming Player Product Details
Netgear NTV200S NeoTV Pro Streaming Player
Experience a different kind of entertainment with the Netgear NTV200S NeoTV Pro Streaming Player. The Netgear NTV200S NeoTV Pro Streaming Player redefines home entertainment as it lets you watch videos directly from Netflix, Hulu, Vudu, Youtube, Pandora, and more, thanks to its Wi-Fi and Ethernet LAN connectivity. Featuring Full HD 1080p Resolution, you can enjoy viewing images from your favorite shows and movies in vivid details and life-like colors. Simply use its HDMI connector to integrate it to your HDTV, and enjoy immersive movie-viewing at home with the Netgear NTV200S NeoTV Pro Streaming Player.
What It Is And Why You Need It:
- Media Player; watch movies and TV shows in stunning Full HD 1080p Resolution
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Manufactured by: NetGear
Warranty provided by: NetGear
UPC No: 606449087208
Mfg Part No: NTV200S
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( Length:6, Width:7, Depth:2)
Shipping Weight: 0.7000 pound(s)
Click here for full warranty and support information
- NetGear logos are registered trademarks of NetGear. All others trademarks and copyrights mentioned herein are the property of their respective owners.


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Milla Jovovich
Rose McGowan Debuts Trippy Debut Single, Plus 10 Other Not-Famous-for-Singing Celebs Who Recorded Albums
Originally posted 09/23/2015 01:20AM
She's best known for her roles in Scream and Grindhouse or on the TV series Charmed, but this week Rose McGowan announced a new phase of her performing career: as a vocalist. On Sunday, she debuted her first single, the Bjork-esque "RM486" and an accompanying music video on the site Nowness.
Milla Jovovich Shares Photos From Daughter's Russian Orthodox Baptism
Originally posted 05/27/2015 12:30PM
The actress shared several black-and-white photos from the religious ceremony
Milla Jovovich: How Co-Sleeping Has Strengthened Our Family Bond
Originally posted 05/15/2015 11:35PM
"Because we share sleep at night, our daughter naturally feels very connected to us," the actress says
New Mom Milla Jovovich Jokes That She's a 'Milk Manufacturing Facility'
Originally posted 04/16/2015 08:45AM
Milla Jovovich shares a sweet pic of 2-week-old daughter Dashiel Edan
Meet Milla Jovovich's Baby Girl! (PHOTO)
Originally posted 04/02/2015 09:35AM
The actress introduces newborn daughter Dashiel Edan
Milla Jovovich Welcomes a Daughter
Originally posted 04/01/2015 11:45AM
The actress and her husband, director Paul W.S. Anderson, welcomed daughter Dashiel Edan on Wednesday
Milla Jovovich: I'm Expecting a Baby Girl!
Originally posted 10/30/2014 11:40AM
"I was actually worried if we had a boy, what would happen to him," the actress says with a laugh
Milla Jovovich Debuts Her Baby Belly
Originally posted 09/05/2014 09:30AM
The actress wowed in a white mini dress at the Venice International Film Festival
Second Child on the Way for Milla Jovovich
Originally posted 08/18/2014 07:45PM
The actress and her husband, director Paul W.S. Anderson, are set to welcome a sibling for daughter Ever
Harley Pasternak Blogs: 3 Exercises for Strong, Toned Arms
Originally posted 09/11/2013 03:00PM
There was a time when I would only hear my male clients talk about how they wanted fit, chiseled arms. Nowadays, almost all of my female clients are adamant about having strong, sculpted arms, and that's thanks, in part, to the über-fit actresses dominating the movie screens of the '90s and early 2000s.
The incredible arms of Hilary Swank in Million Dollar Baby, Halle Berry in Catwoman, Demi Moore in G.I. Jane, Resident Evil's Milla Jovovich, and Angelina Jolie in Tomb Raider, all inspired women to lose the sleeves and focus on making their arms as amazing as the rest of their bodies.
There are two main muscle groups in the arms: The biceps, which are located on the front of the upper arms; and the triceps, which are on the back of the upper arms. The main function of the biceps is to bend the elbow, while the triceps straighten the arm at the elbow.
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Seriously Dead Starring Crissy Rock
Wednesday 12th October 2016 @ 7:30pm - A brand new comedy play that will have you dying with laughter! An everyday tale of passion, poison, pies, pasties and romance!
Duration 70 minutes + 20 minute interval + 70 minutes (approx)
Production Professional
Price range
Key to seating (online bookings)
Age and suitability No restrictions
Venue Towngate Main Auditorium
Seating Plan View Main Auditorium seat plan
One ordinary day in the quiet little town of Olwinskirk, a chain of extraordinary events began to take place bringing the lives of Betty, Albert, Billy and the local undertaker -Tristan de Winter - to an uncomfortable crossroads.
Albert Blunderstone has been hiding abroad for ten years after having committed a bank robbery with a small time crook called Nodger Wilson. On the day that he flies home to attend a funeral, he runs into Betty who used to be married to Nodger and in an attempt to find out what happened to his share of the dosh, he befriends Betty and her current husband Billy Blenkinsopp.
The lives of Betty, Albert, Billy and the local undertaker Tristan de Winter become inextricably linked towards a path that is leading to The Pearly Gates and a disgruntled Guardian Angel named Thelma.
A brand new comedy play that will have you dying with laughter!!
Written by Leah Bell and Crissy Rock
Original Music by Mike Redway
HEALTH WARNING: This show could damage your cheeks!


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Technical Notes
This vodka is produced in small batches using organic white corn. The process is done by carefully in a process that takes 20 days. Cold-water sweet mash fermentation is used and the vodka goes through seven distillations. Finally, it is polished using water that is rich in limestone.
The infused flavors in this vodka are very strong. There is no doubt about the freshness of the cucumber and lime in here. It's flavorful enough that it really doesn't need to be mixed with anything. Serve it over ice, with some club soda if you'd like to dilute it.


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MMA Forum - UFC Forums - UFC Results - MMA Videos (http://www.mmaforum.com/forumindex.php)
- UFC (http://www.mmaforum.com/ufc/)
- - Jeremy Stephens Injured, Thiago Tavares Steps In At UFN 20 (http://www.mmaforum.com/ufc/68015-jeremy-stephens-injured-thiago-tavares-steps-ufn-20-a.html)
Jeremy Stephens Injured, Thiago Tavares Steps In At UFN 20
According to MMAJunkie, it looks as if Thiago Tavares (14-3 MMA, 4-3 UFC) will replace the injured Jeremy Stephens (16-4 MMA, 4-4 UFC) and face Nik Lentz (17-3-1 MMA, 1-0 UFC) at UFC Fight Night 20. Here is the updated card for UFC Fight Night 20, which takes place Jan. 11 in Fairfax, Va.
- Nate Diaz vs. Gray Maynard
- Brad Blackburn vs. Amir Sadollah*
- Evan Dunham vs. Efrain Escudero
- Tom Lawlor vs. Aaron Simpson
- Thiago Tavares vs. Nick Lentz*
- Chris Leben vs. Jay Silva
- Jesse Lennox vs. Rick Story
- Mike Guymon vs. Rory MacDonald
- Kyle Bradley vs. Rafael dos Anjos
- Tim Credeur vs. Mike Massenzio
- Nick Catone vs. Steve Steinbeiss
WTF? Why are Tim Credeur and Chris Leben in the prelim cards when there are nobodies on the main card? I realize Chris is on a losing streak but he still entertains. There's no excuse for Credeur though.
Yeah, I'm pissed that Lebens fight is on the prelims. :(
Tom Lawlor, Aaron Simpson and Brad Blackburn get on the main card ahead of Chris Leben =/ Who decided that?
The UFC really aren't having much luck with injuries atm though are they. I know this isn't a big fight thats been changed, but even so, the amount of injuries in the last few months have been ridiculous. Must be driving them mad.
I've been looking forward to see Simpson and Credeur fight, im glad that Simpson is on the main card.
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Alex, and the unwritten rules of Baseball
Never mention a no-hitter while it's in progress. Don't take the bat out of your best hitter's hands by sacrificing in front of him. Don't steal third with two outs. Never make the first or third out of an inning at third base. Never put the tying or go-ahead run on base. These are some of the unwritten rules of Baseball that we've all grown up with. Yesterday, Oakland A's pitcher Dallas Braden informed Alex Rodriguez of another unwritten rule. One that Alex and some members of the media claimed to have never heard of before.
Never run over the pitcher's mound during an inning, and never, ever step on his rubber.
To be honest, this one is nothing new to me. I've heard this one before, but never with the qualification about the rubber. Pitchers consider the mound to be their office, where they do their business, and as such they don't appreciate people invading what they consider to be their personal space while they're working. It's not something that comes up very often, most Baseball players would simply run around the mound for a variety of reasons, even between innings. Here's what Braden said about the incident:
"I don't go over there and run laps at third base," Braden said afterward. "I don't spit over there. I stay away. You guys ever see anybody run across the mound like that? He ran across the pitcher's mound. Foot on my rubber."
When asked about the incident, Alex acted perplexed. He said:
"He just told me to get off his mound," Rodriguez said. "That was a little surprising. I've never quite heard that. Especially from a guy that has a handful of wins in his career."
Color me dubious. A-Rod has had a history of questionable incidents on the field, from the ball slapping incident with the Red Sox Bronson Arroyo to the 'HA!' shouting incident with Toronto third baseman Howie Clark. Alex has been in the game far too long to have never heard of this little bit of Baseball etiquette. It may have been a bit of gamesmanship, an attempt to get under Braden's skin, who is not a hard thrower and had the Yanks off balance all day. Or it may have been his way of saying 'I'm A-Rod and you're a rookie'. His comment about Braden having 'a handful of wins' certainly bolsters that charge. Or maybe he's just so wrapped up in himself that he doesn't consider the feelings of others. Whatever the explanation, these incidents always leave me scratching my head with Alex.


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Anyone, regardless of their success level, who tells you they do not fear….is a liar.
We all have fears and as you grow and become more successful you never lose your fears, they just change into different fears. The good news is that when you conquer one fear you build up confidence that you can conquer another. So while the fear is constant, our ability to cope with the fear becomes more efficient.
If you have read any of my posts or watched some of my videos you are probably aware that I have dealt with some off the charts, unhealthy fears. Last month was no exception…
I received an email from Entrepreneur Magazine asking me if I would consider being a weekly article contributor. This is a HUGE honor. To go from being the woman who could not see any value in herself, just a few short years ago, to being the woman who is being asked to write articles for entrepreneurs around the globe was unfathomable.
My first reaction was bewilderment, then excitement, which quickly turned into a sickening feeling in my stomach, which then ended in paralyzing fear. I began to think of all of my "idols" who write for Entrepreneur. There was no way I was on their level. Was Entrepreneur lowing their standards? Were they desperate for contributors?
(Related: VIDEO: Fear Is My Motivator)
I thought about pretending I never received the email. I thought about writing back and explaining that I was grateful for the offer to write for millions of people around the world, but….uh, I'm just too busy…..I just got a new cat and all.
I realized what I was doing. I have been down this path many, many times before. I knew that my lack of self-worth was creeping back in. In the past I would never talk to people. I never shared bad news OR good news. I never wanted to be held accountable. These things never got me anywhere.
I've learned from my mistakes and I contacted my business coach and immediately told him about the email. He would hold me accountable. Did my fears disappear? NO! But my fear of telling my business coach that I was making excuses was far worse than my fear of looking like an idiot for Entrepreneur Magazine. (Point #1: Have someone in your life who will hold you accountable.)
Fast forward to this week. My first article was published. Because I'm a perfectionist I still felt that there were things I would like to change but they published it anyway. I was terrified that no one would read it….or that there would be nasty comments at the bottom. How embarrassing to publish your first article to have only two people share it? PLUS, they published my article on the exact same day at the exact same time as an article submitted by Richard Branson…..THE Richard Branson…..SIR Richard Branson…..the multi-billionaire. (sigh)
At the time I am typing this post my article has been up for 48 hours. Here are the stats:
That's right Richard Branson, you may own an island but more people shared my article.
(And I mean that in the most respectful way possible, sir.)
I'm not sharing this for the purpose of bragging (well…maybe just a little). However, I am certain Mr. Branson is not the least bit concerned about the number of shares he has compared to mine. But I believe he would agree with the moral of this story.
Do you think I'm excited about writing another article for Entrepreneur?!? YES! Do you think I'm going to have the same fear and anxiety this time? No way!…I beat out RICHARD BRANSON
I feel empowered. I am ready to take on the WORLD (or at least another article). (Point #2: Taking action is the BEST way to overcome your fears. The more action you take, the more fears you will overcome. The more fears you overcome, the better equipped you are to face future fears.)
This is for all of the people out there who DON'T have a net worth of $4.8 billion….yet:
Sir Richard Branson: 4 Billion Katherine Keller: 1
Update: You guys are amazing. I know many of you read and shared the article and were a large part of that original 4,000. It is now over 5,000 shares. My feelings of gratitude are overwhelming. Thank you!
[suffusion-widgets id='1′]


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Charges against former West Allis teacher dismissed
Case dropped after four postponements by prosecutors, but can be reopened
A judge has dismissed charges against a former West Allis teacher charged last year with sexually assaulting a student in 2005.
The case against Gregory Groskreutz, 35, had been set for trial four times, and four times prosecutors asked for postponements, said his attorney, Jonathan LaVoy. On Monday, Circuit Judge Rebecca Dallet granted LaVoy's motion to dismiss the case without prejudice, meaning prosecutors could refile the charges.
Deputy District Attorney Kent Lovern said three of the requested delays were because the alleged victim in the case has a significant medical condition that is aggravated by stress and was hospitalized at the times when the trial had been set. He said his office does intend to restart the case if and when the girl's health permits.
LaVoy said his client is happy the case is behind him.
"Mr. Groskreutz had maintained his absolute innocence through the entire matter and very much wanted a trial, his day in court. He wanted to clear his name."
The incident supposedly occurred during a lock-in at Frank Lloyd Wright Intermediate School in 2005, when Groskreutz taught social studies and the girl was an eighth-grader.
LaVoy said other students told teachers that the girl and Groskreutz had been in his classroom alone during the lock-in, but both denied anything improper occurred when the School District investigated, and school officials closed the matter then.
Then in 2010, the girl told police that Groskreutz had assaulted her, and police then secretly recorded a conversation she had with Groskreutz at a coffee shop. LaVoy described that recording as confusing at best.
Groskreutz is appealing his termination from West Allis schools, LaVoy said, and will cite the dismissal of charges.
"I suspect this will be helpful, but whether it carries the day, I'm not sure," LaVoy said. "Or even if he wants to work at West Allis after the way they handled this."
Search homicides in the city of Milwaukee by location, age, race, gender and date.


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Rev. James Dumont: Jesus offers abundant life
According to popular legend, Ponce de León discovered Florida while searching for the Fountain of Youth. His quest was to hold death at bay.
To this day, the health and cosmetic industry uses every means from creams to cryogenics to cheat death and pursue longevity.
Woody Allen once said, "I am not afraid of death; I just don't want to be there when it happens."
In our hearts, we know we are part of something greater than our physical senses reveal.
We embrace the beauty of life and yearn for a life unaffected by death. Death is hated and feared.
It cruelly cuts short human potential and destroys hope. Death affects everyone.
No man ever spoke as boldly as Jesus regarding death. He did not offer soothing sympathetic sonnets.
Jesus came to take on death and to offer life. Only Jesus, by means of his journey into the dark shadows of death and return to life, can allay our fears and clarify our purpose. Only he can give us hope.
Perhaps this summer you may go on a hike or white-water rafting. If you are unfamiliar with the terrain, you may wisely employ a guide. The guide has been there and therefore is trustworthy to be your eyes. He will get you safely home after you enjoy the journey.
The Scriptures refer to Jesus as our "forerunner" or someone (the only one) capable of being our guide.
Jesus himself took on death and defeated it. Jesus has been to hell and back, and now he offers to us his life -- abundant life.
In John 10:10, Jesus says, "The thief (Satan) does not come except to steal, and to kill, and to destroy. I have come that they may have life, and that they may have it more abundantly."
"Abundant life" means life beyond the grave as well as the ability to enjoy the journey while living on this earth. It is the God kind of life that defeated the power of sin and death.
The way to receive this life is by receiving Jesus as your savior.
Reflections is a column by religious leaders in the region. The Rev. James Dumont is pastor of Erie Christian Fellowship Church, 5900 Sterrettania Road.


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Parish Social Events
Below is a listing of our parish social events and we welcome everyone to join us in the spirit of friendship and fellowship!
Please note that some details are subject to change. For more information about any of the events, please call the parish office.
Senior Citizens' Suppers
Held monthly for our senior parishioners, friends and neighbors. Click here for the 2016 schedule.
Hospitality Sundays & Saturday Potlucks
Held monthly for our parishioners and visitors. Click here for the 2016 schedule.
(June 2016 - no Potluck due to other conflicts)
RE/CYM Fundraiser
Held for the benefit of our Religious Education (CCE) and Catholic Youth Ministry (CYM) programs.
2016: Thank you to everyone who joined us in January for our fundraiser this year. The children of our programs benefit tremendously from your generosity! God bless!
Czech Mass
Celebrated annually in honor of Sts. Cyril and Methodius, the patron saints of the Slavic people, whose feast day is February 14. The Holy Trinity Parish was founded by the Corn Hill community, which consisted of many Slavic immigrants. We celebrate this Mass as a way of remembering and honoring the heritage of our parish. Many of our parishioners today are descendants of these founding families.
2016: Join us on Sunday, February 14, at 10:30 a.m. for Mass, which will be celebrated in the Czech language and accompanied with traditional Czech hymns. A meal will follow in the Parish Activity Center for all in attendance. (The attendance of this 10:30 a.m. Mass fulfills your Sunday obligation.)
June Fundraiser
Held annually on the first Sunday of June.
2016: Join us on Sunday, June 5, for Mass in the church at 10:30 a.m. with traditional Czech hymns sung by our choir and the Happy Czech Singers of Austin. Enjoy a Fried Chicken & Sausage meal, with homemade dressing, noodles and green beans, served from 11:00 a.m. - 1:00 p.m. in the Parish Activity Center. Adults $10 / Children $5. Drive-thru will be available. Dance from 1:00 - 5:00 p.m. to the music of the Jodie Mikula Orchestra (free-will donation). Great food and friendly fellowship!
Parish Bazaar
Held annually on the third Sunday of September.
2016: Join us on Sunday, September 18, for Mass at 10:30 a.m. and then enjoy a delicious, homemade BBQ & Fried Chicken dinner with all the trimmings, served from 11:00 a.m. - 1:00 p.m. in our Parish Activity Center. Adults $10 / Children $5. To-go plates available at drive-thru. Spend the afternoon with us for live Polka Music, Live Auction, Silent Auction, Kid's Games, Bingo, Raffle ... fun for the whole family!


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Who we are / Message from the chairman / Message from the director / Board of Trustees / AFAC's Circle of Friends / Team / Partners
AFAC's Circle of Friends are culture aficionados passionate about supporting the arts in the Arab world today. They recognize artistic production as an expression of creativity and talent. They believe that cultural work is a valuable source of inspiration and thought, that it helps make the world a better place. And so, they offer their time and their resources to help spread AFAC's vision within their communities. They are ambassadors for AFAC and we would like to thank them for their support.
Najat Rizk
Olivia and Bassem Snaije
Rana Sadik
Rasha Salti
Rula Alami
Saadallaha and Lubna Khalil
Yola Noujaim
Marie Boghossian
Site Map | Contact Us | Copyright © 2016 AFAC | Designed by Omar Mismar | Developed by Fusion Second.


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Created in this Craftsy class
Chain of Stars Mystery Quilt taught by Kimberly Einmo
What is beautifully designed, one of four different sizes and an all-around mystery? The quilt top you'll be making in Kimberly Einmo's class!
Other projects made as part of this class:
QuiltingClue 7
QuiltingSweet "baby " Quilt
QuiltingPaisley Chain of Stars
Offer some kudos...
Join the conversation...
Ask a question...
Add your comment...
Black, white & red quilts have always been my favorite - but haven't yet made! I love your look!!! Striking and dramatic!!
12/04/2014 Flag
Looks great as a Christmas quilt.
04/05/2016 Flag


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MILAN — Furla SpA said Tuesday chief executive officer Paolo Fontanelli has left the company at the end of his three-year contract.
This story first appeared in the March 31, 2010 issue of WWD. Subscribe Today.
A spokeswoman for the Italian accessories house said a new ceo will be named within the next two months.
Fontanelli joined Furla in 2007 from Giorgio Armani, where he was ceo. He was recruited to Furla to develop the company and the brand's image internationally, stepping up the firm's structure and management.
Under his direction and that of Giovanna Furlanetto, daughter of founder Aldo Furlanetto and chairman of the family-owned company, Furla has grown its retail network to 320 stores from 255, including flagships in London and Barcelona. A flagship is expected to open in Paris, on Boulevard des Capucines, next month, followed by one in Beijing. Also, Furla's e-commerce site was unveiled at the end of 2008.
Revenues for 2009 are not available yet, but the spokeswoman said sales are expected to be in line with the previous year, which closed at 157 million euros, or $230 million at average exchange rate for the period.


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To which item(s) do you want to associate this flyer offer?
All selected items will be added to your shopping list.
This will allow you to get the flyer, the offers and the coupons available in your region.
saddles of rabbit
extra virgin olive oil
heavy cream (35% m.f.)
Salt and pepper to taste
pinot noir demi-glace
carrot, cut into brunoise (very fine dice)
onion, cut into brunoise (very fine dice)
brown sugar
pinot noir
sirloin beef
scampi shells
garlic cloves
veal jus
thyme to taste
savory to taste
rosemary to taste
salt and pepper to taste
cauliflower mousseline
cauliflower, cut into florets
heavy cream (35% m.f.), lukewarm
salt, pepper to taste
nutmeg to taste
warm vegetable salad
carrot, cut into sticks
red pepper, cut into sticks
yellow pepper, cut into sticks
celery, cut into sticks
yellow carrot, cut into sticks
handful snow peas, cut into large julienne
Chopped fresh parsley to taste
Chopped thyme to taste
Rabbit Paupiettes
Clean and bone saddles of rabbit. Remove flaps and nerves, leaving 4 small cylinders. Reserve flaps for the stuffing.
Slit the cylinders and open them up like a scaloppine.
Flatten them so that they can be easily rolled up.
Clean, season and sear scampi in olive oil over high heat until browned but not cooked, and keep cool.
Put rabbit flaps and trimmings in a food processor along with chorizo, salt and pepper and chop into a dense stuffing.
Add cream to soften, and adjust seasoning as needed.
Force stuffing through a mill to remove fibres and nerves. Reserve.
Spread each saddle, salt lightly, use a spatula to cover the whole surface with stuffing, and lay 11/2 scampi in the centre.
Roll saddles into 4 cylinders, wrap tightly in plastic film and vacuum seal. (If you don't have a vacuum sealer, wrap them in plastic film, then twist and knot both ends).
Steam for 20 minutes and cool in an ice bath.
Just before serving, reheat vacuum-sealed scampi in a double-boiler for 5 minutes to 175°F (80°C).
Pinot Noir Demi-glace
In a saucepan, sweat carrot and onion.
Add brown sugar and deglaze with pinot noir.
Reduce, then add beef broth, scampi shells, garlic, thyme and rosemary.
Reduce by 3/4, and strain through a chinois (china cap or conical strainer).
Add veal jus and strain again for demi-glace, season, and stir in butter.
Cauliflower Mousseline
Cook cauliflower in boiling salted water. Drain as thoroughly as possible.
Purée in food processor with warmed cream, and season with salt, pepper and nutmeg.
Warm Vegetable Salad
Blanch vegetables individually in boiling salted water, cool and spread out on a baking sheet.
Before serving, warm them in the oven, and dress with butter and chopped herbs.
Plate and serve!
Deff Haupt
Executive Chef, Renoir restaurant, Sofitel Hotel
Source: Magazine Flaveurs
Aromatic and supple
These medium-bodied wines are characterised by their smooth tannins that usually confer a certain roundness. They are often dominated by a nose of ripe fruit or woody notes (toast, coffee or vanilla).
Product category: red wine.
© Société des alcools du Québec, 2007
Make sure you are using only gluten-free cereals, flours and starches, and read the labels carefully when you buy these products.
Metro Richelieu inc., its affiliated companies and affiliates are not responsible for any circumstance that should come up when using the suggested recipes. Each person using this site must check that each of the ingredients is allowed in his/her diet and is not part of his/her restricted foods.
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Julie Gold
|This biography of a living person needs additional citations for verification. (May 2015) (Learn how and when to remove this template message)
|Julie Gold
Julie Gold performs at the M'korstock event at Congregation M'Kor Shalom synagogue in Cherry Hill, New Jersey in 2009
|Background information
February 3, 1956
Havertown, Pennsylvania
|Singer, songwriter
|Vocals, piano
|Years active
|1978 – present
|Associated acts
|Nanci Griffith, Four Bitchin' Babes
Julie Gold (born February 3, 1956) is an American singer-songwriter. She is best known for her musical composition "From a Distance," which became a big hit for Bette Midler and won the Grammy for Song of the Year in 1991.
That song has since received close to four million airplays. It has been recited into the Congressional Record (by Senator Barbara Boxer). It has been recorded internationally and translated into many languages. It has been illustrated as a children's book and mass-produced in music boxes. It has been quoted in books, calendars, and greeting cards. It was used as the wake-up call for astronauts in the Mir space station the first time Americans worked with Russians in space. A wide range of recording artists has covered it, including Jewel, Elaine Paige, Cliff Richard, the African Children's Choir, Judy Collins, the Byrds, Fairport Convention and Donna Summer.
Nanci Griffith, the first to record "From a Distance", has also recorded Gold's songs "Heaven", "Southbound Train", "Good Night New York", and "Mountain of Sorrow". Other artists who have covered Julie Gold songs include Patti LaBelle, Patti LuPone, Lea Salonga, and Andrea Marcovicci. Her song "Thanks to You" was featured in the 1993 film Andre, and her song "Dream Loud" was featured in the 2002 film Unfaithful.
Julie Gold is originally from Havertown, Pennsylvania and later moved to Philadelphia, Pennsylvania; she graduated from the Philadelphia High School for Girls in 1974. She graduated from Temple University in 1978 and appeared as a featured live performer in many of the premier legendary Philadelphia area coffee houses and entertainment venues including the Main Point, Bijou Cafe and others. From 1990 to 1994, she was a member of Four Bitchin' Babes, along with Christine Lavin, Megon McDonough, and Sally Fingerett.
Her Jewish paternal grandparents were immigrants from Romania.[1]
- ^ Scott R. Benarde (July 2003). Stars of David: Rock 'n' Roll's Jewish Stories. p. 332. ISBN 1-58465-303-5.
External links[edit]
|Wikiquote has quotations related to: Julie Gold
|This article on a singer-songwriter is a stub. You can help Wikipedia by expanding it.


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For help with your order,call us on01795 542014
Grant's Morella Cherry Brandy dates from 1774. It was a favourite with Queen Victoria, holds a Royal Warrant from the Prince of Wales and is celebrated by Charles Dickens in The Pickwick Papers. Grant's Morella Cherry Brandy is still produced to the highest quality and continues to maintain the flavour and tradition of its celebrated past.
Contact us by email
Contact us by phone
Shepherd Neame LimitedThe Faversham Brewery17 Court StreetFavershamKent. ME13 7AXUnited Kingdom
Shepherd Neame is authorised and regulated by the Financial Conduct Authority for consumer credit regulated activities.


text:
Narrow down the 14 results:
x The average starting price for a place to stay in Rapid City is £61 per night.
Outfitter Road Next To 3231 E Mall DrExcellent 90%
4040 Cheyenne BlvdGreat 80%
1314 Elk Vale RdGreat 80%
1740 Rapp StGreat 80%
1416 North Elk Vale RoadGood 70%
2505 Mount Rushmore RdGood 70%
1625 N. LaCrosse StreetGood 70%
2520 Tower Rd US Hwy 160 50%
Create your own travel plan including Rapid City as one of your stops. You can use it to store all your research (even hotels found on other websites!)
Do you have questions about Rapid City? You might try asking in our active travel forums and see if anyone else has been there.
Keep your family and friends up to date with your trip by starting your own travel blog!


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A: Support.
Why is this important? A study by the federal government's Justice Department found that 1/3 of defendants released before trial ended up being charged with some type of pre-trial misconduct. 1/6 were arrested for a new offense--and half of those were felonies.
The federal government allows a violent criminal who is a danger to the community to be held without bail. NJ law does not. This must change. How can we justify exposing our citizens to the risk of violent crime at the hands of those, already in custody, who we know are disposed to commit it? There is no justification for that. Let us mirror federal law. Pass bail reform now.
This may require a constitutional amendment but it is reform that is long overdue. Do you know that if a person is arrested with a long record of violence we cannot detain that person in jail pending trial? We must release that person, regardless of how dangerous they are to potential witnesses against them or innocent members of our society. Let us amend our bail laws to allow judges to consider the factor of dangerousness to our communities before we release a violent person back on to the street to maim or kill while they await trial. This is just simple common sense.
Alerted via e-mail every time there was a shooting, and frantic to avoid another one, he started hitting the hoops court at midnight to help keep kids busy and out of harm's way. Then he began going out on night patrols in cruisers with cops, rolling up to shady characters and initiating come-to-Jesus conversations about what they were doing with their lives. The foolhardy gambit had its impact: Booker's dedication started to rub off on the department. More orthodox strategies have included what's known as the broken windows theory--the idea that attention to basic quality-of-life issues can ultimately help avert serious crimes.
This bill would establish new crimes concerning forced labor and sex trafficking. Both of these activities represent a modern form of slavery, in which ever increasing numbers of persons, primarily women and children, are trafficked across international borders and into this State. Forced labor and sex trafficking would each be categorized as a crime of the second degree.
Also, if a person destroyed, concealed, or possessed the passport or any other government-issued identifying document of a victim, while in the course of committing, attempting to commit, or conspiring to commit, the crime of forced labor or sex trafficking, the person would be guilty of a crime of the third degree.
|2016 Presidential contenders on Crime:
Gov.Jeb Bush(FL)
Dr.Ben Carson(MD)
Gov.Chris Christie(NJ)
Sen.Ted Cruz(TX)
Carly Fiorina(CA)
Gov.Jim Gilmore(VA)
Sen.Lindsey Graham(SC)
Gov.Mike Huckabee(AR)
Gov.Bobby Jindal(LA)
Gov.John Kasich(OH)
Gov.George Pataki(NY)
Sen.Rand Paul(KY)
Sen.Marco Rubio(FL)
Sen.Rick Santorum(PA)
Donald Trump(NY)
Gov.Lincoln Chafee(RI)
Secy.Hillary Clinton(NY)
V.P.Joe Biden(DE)
Gov.Martin O`Malley(MD)
Sen.Bernie Sanders(VT)
Sen.Jim Webb(VA)
2016 Third Party Candidates:
Roseanne Barr(PF-HI)
Robert Steele(L-NY)
Dr.Jill Stein(G,MA)
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