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Re: Will there be a new and improved Nook e-reader in 2015?keriflur Dec 13, 2014 10:38 AM (in response to LectorGS)
I'm not sure if we'll see one, but if we do, I agree, I don't see it being much of a contender. I'd expect an updated entry-level device, the e-ink equivalent to the NGTS. Hopefully B&N will prove us wrong and put out a knockout device.
Re: Will there be a new and improved Nook e-reader in 2015?Froide Dec 14, 2014 8:33 AM (in response to LectorGS)
Since this is how I assess the trajectory of the NOOK color tablet/ereaders to date, I'm not waiting with 'bated breath. Nonetheless, like keriflur, I'm hopeful "B&N will prove us wrong and put out a knockout device".
Re: Will there be a new and improved Nook e-reader in 2015?flyingtoastr Dec 14, 2014 10:53 AM (in response to LectorGS)
It depends what you consider a "contender". Yes, the Voyage or H2O are great devices with a host of very nice features, but their pricepoints put them far outside the range of mass market devices. Remember, the Kobo Aura HD had exactly 300000 units produced (known thanks to eInk discussing the size of the production run on the Aura HD's very unique screen), and almost two years later they are *still* for sale. And, mind you, that's with Kobo selling the device in more than thirty countries, not two like BN.
Amazon has also been strangely silent on sales of the Voyage. In their annual Black Friday circle jerk press release Amazon loves to brag about how well their new devices are selling. This year, there's just a generic "ereader sales are up!" blurb, with almost no mention of the Voyage at all aside from a single line lifted from a TechCrunch review. Their TV dongle gets more press than their flagship reader!
I see these Cadillac ereaders and think of an actual Cadillac. Sure, everyone would love to drive home in a car with heated leather seats and a stereo system that puts IMAX theaters to shame, but when it comes down to signing on the dotted line most people will opt instead for the Nissan that serves the same purpose at a fifth of the price (with a little less style).
The only way I see BN pushing out this kind of niche of a niche device that "contends" with the H20 or Voyage is if they can get it produced in a smaller run than normal (<100k) to fit with the smaller demand for these $150+ devices. Otherwise I just don't see it happening, why produce a device that sells poorly when you can make a cheaper model that will sell better. Remember, the devices are loss-leaders, they exist solely to sell content, so getting volume of sales is important.
Of course, I've never felt that high end hardware is where BN should be competing with Amazon anyway. They should have been competing on experience - making synergies between the stores and the devices instead of having one at the expense of the other. But with the impending imbecilic carving up of the company there's even less of a chance of that happening now, so I'm ready to be disappointed.
Re: Will there be a new and improved Nook e-reader in 2015?keriflur Dec 14, 2014 12:10 PM (in response to flyingtoastr)
IMO a contender would be a device that brings something to the table that isn't there already. I don't mean a new feature necessarily, but rather a quality level or mix of features that doesn't currently exist and fills a need. Something that makes nook owners want to buy a new nook and makes non-nook-owners want to buy a nook. This is how sales happen.
Re: Will there be a new and improved Nook e-reader in 2015?LectorGS Dec 14, 2014 7:18 PM (in response to LectorGS)
I agree with you 100%. Innovation is the key word here. However, e-readers are reaching the point of being another device or pseudo-tablet. You mention that the "coup de grace" would be bringing to the table something that "fills a need." What do you think that "something" could be? I am afraid B&N will launch an e-reader that is lighter and perhaps has a better screen resolution. I don't think they are going to add anything that would entice both current and new Nook readers/users to buy the newer device.
As flyingtoaster stated earlier in his reply, even the Voyage, amazon's newest version of the Kindle, has not been doing well, sales wise. I have visited, in several occasions, the Kindle forums, and it seems that the general consensus is that it's too pricey for what it does. Some of the comments are that current users of the KPW don't feel the need to upgrade.
This the opposite in the Nook world, where, the e-readers have not reached a point of evolution yet. i hope to be pleasantly surprised. In the meantime, I will continue using my three-year-old NST.
Re: Will there be a new and improved Nook e-reader in 2015?keriflur Dec 14, 2014 10:57 PM (in response to LectorGS)
I'm a current KPW user and I don't feel the need to upgrade. I still asked for a Voyage for Christmas though, because it has more storage.
8gb or, hey, 16gb in an eink would be something we haven't seen before. Pair that with an ultralight weight (like the current eink nook) and a triton screen and I'd be interested.
Re: Will there be a new and improved Nook e-reader in 2015?Sandikal Dec 15, 2014 4:31 PM (in response to LectorGS)
I'm hoping that the next generation Nook e-ink device comes out soon so I can get a great price on a Nook Glowlight. I find the tablet devices to be too distracting, but I can't justify getting a Glowlight at the current price.
Re: Will there be a new and improved Nook e-reader in 2015?MacMcK1957 Dec 15, 2014 5:06 PM (in response to LectorGS)
I can't help but wonder whether the most effective move might be a low-end reader, $50 range, that might attract new readers rather than people wanting to upgrade. I just below there is still a large untapped market of DTB readers.
Re: Will there be a new and improved Nook e-reader in 2015?keriflur Dec 15, 2014 9:03 PM (in response to MacMcK1957)
B&N has done the low end reader thing. The NST was $50 (or close to it) for quite a while. IMO their current reader is about as low end as they should go. Maybe it will sell better at $50? Either way, that tactic doesn't seem to growing their market much.
Ultimately the reader is solely a vehicle to sell content. They need to figure out what their big content buyers want in a device, and offer that, before they lose those folks. Then they need to figure out how to increase the number of big content buyers.
Re: Will there be a new and improved Nook e-reader in 2015?bobstro Dec 16, 2014 1:56 AM (in response to keriflur)
We may be hitting the optimum of what a "dedicated" eink reader can do hardware-wise and still be that not-a-tablet device with weeks of battery life and an outdoor readable screen. I think the Kobo H2O and Amazon Voyage are, at best, incremental improvements over a mostly successful form factor. I do hope to see improvements to screen technologies, battery life, and hey, a lower price is a good thing. Text-to-speech and maybe audiobook integration might be useful.
Where there's loads of room for improvement and innovation is in the software. Visit any of the manufacturer's support forums and you find loads of complaints about various functionality. Rather than sinking money into R&D, put some into software improvements that make reading a pleasure, maintaining (and buying) content easy and quit worrying about "owning" the user.
B&N obviously doesn't manufacture the NGTS. Kobo doesn't manufacture their devices. They contract with hardware firms that have the experience and scalability to put out nice devices affordably. B&N doesn't have to tool up to manufacture anything these days.
Put out some reasonably competent hardware (again), but this time, put some serious effort into developing the software.
Re: Will there be a new and improved Nook e-reader in 2015?MacMcK1957 Dec 16, 2014 5:26 AM (in response to keriflur)
The current reader, with the glowlight, is priced at $99 to compete with the KPW. Amazon still has a base-model lightless Kindle at $60. By eliminating the base NST, B&N said they didn't even want to compete in that market, which I have to feel is a mistake.
Re: Will there be a new and improved Nook e-reader in 2015?keriflur Dec 16, 2014 8:07 AM (in response to MacMcK1957)
My assumption is that they weren't making any money that way. FWIW, the NGL does not compete with the KPW. Not by a long shot. It's sort of in between the kindle models - it has a higher res screen, but nowhere near as crisp and contrasty as the KPW's triton screen. It has a light, but it's got a distinct blue cast - passable, but not competing with the KPW's clear, white light. It's got more storage space, but as the user is restricted in how they use the partitions, for some folks, they'll get more books on the KPW. And on and on.
It's not a flashy new feature that's needed - improve on the current features for a competitive device, downgrade the current device to an intro model (which, IMO, it already is, but price it as such), and that's all that's needed.
Well, and allow sideloading of books. No matter what the device is, I'm not interested in books I can't back up or sideload.
Re: Will there be a new and improved Nook e-reader in 2015?AnitaInTN Dec 16, 2014 8:40 AM (in response to keriflur)
For their e-ink and tablet options both - BN needs to work on the software, and, frankly, their attitude / direction. The move to Anti-Social DRM, the deliberate torpedoing of side-loading and backup - while I do like my NC and newer Sammie Nook (SGT4N-7) - I have the advantage of having an old account for some little while yet. (I do anticipate losing this in time, with BN's new direction.) Anyone just getting into e-readers, someone who would get the "new and improved <sic> BN" - I cannot in good conscious recommend the Nook garden to a newbie now. I hope BN's direction changes, I really do. (but not holding my breath and dreading the "new" website to be rolled out 2015)
Re: Will there be a new and improved Nook e-reader in 2015?RHWright Jan 2, 2015 12:07 PM (in response to LectorGS)
I would love for B&N to surprise us with something new and exciting in the e-ink realm. As others have mentioned, there are only minor things to do on the hardware front.
B&N needs to step up in the user experience arena, IMO. (Not just in e-ink, but across the board, but the e-ink has seen a lot less love in the last 12-18 months.)
Things they could do to innovate:
- Way better shelving & library management. Like we haven't been saying this for, literally, YEARS.
- More promotional innovation. This is not entirely under B&N's control, but deals on multiple books from an author, completing a series, and other bundles would be nice.
- A more integrated device-B&M store experience. I know those who don't live near or care to go into a store could give a rat's about this type of thing, but one thing B&N still has over Am***n is their physical retail presence. The ability to shop the physical store for in-store items for shipping or pick-up would be something others can't match. Heck, even just the ability to shop non-e-books on bn.com and have them shipped would be nice.
- Align systems, hardware, DRM, etc. to make it easy to be the preferred device to read on; make it simple to bring my existing content to their device. Because, yeah, once I'm there, I'm more likely to just stay there and buy content at B&N.
- Better wishlist management. Let me sync them if I want to or not. Having to remember that they are device-specific, plus on the website is a chore.
- Yet, the archiving function is all or nothing, at least in the last version of the NST & Android app software.
- Price drop/sale alerts for items on my wish list(s). I check regularly sure, but the temptation when it is shoved in my in-box that Book X on my wishlist has dropped from $A to $B for a limited time is a much surer sale than the generic marketing emails they send out.
- Smarter marketing. The ship may have sailed, but at least try to push back the idea of "Kindle"=the generic of e-reader.
Honestly, I don't have any idea what I will do when the ol' NST finally gives out. The Voyage is tempting, as are some Kobo models. The current B&N offering is underwhelming.
Re: Will there be a new and improved Nook e-reader in 2015?lovemyereaders Mar 5, 2015 2:37 PM (in response to LectorGS)
I would love to see a new updated glow light to compete with the voyage, or even the glowlight in a different color. The eink ereaders are losing out to the tablet market. So many people now read on their phones and tablets. I started using my tablets and phones more for a while, then realized that my eyes were hurting more, so I went back to my nooks and kindles.


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January 4, 2013
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Posted January 6, 2013 10:08 pm - Updated January 7, 2013 12:06 am

subset: commoncrawl


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The Summer Reading Game starts Monday, May 23! Pick up your free gameboard at the Main Library, Ellettsville Branch, or Bookmobile and Read for the Gold!
- Get Your Game Board Online! [1]
Try the Computer Question [2]
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I operate a Inspiron 1501, a Inspiron 6400 and a Vostro 1520 on lubuntu 12.04, ubuntu 10.04 and on ubuntu 12.04 LTS respectively. All show the following phenomenon:
after power on a flashing cursor in the upper left hand corner on a black screen for 1-2min after that grub seems to kick in (with GRUB_HIDDEN_TIMEOUT=10 in the grub.cfg one can see the countdown from 10 to 0 AFTER the two min waiting time) at this point boot proceeds with expected speed.
What happens during those 1-2min? How could I diagnose this?
Help is greatly appreciated. From the forum activities I conclude that I am not the only one dealing with this problem.


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Marilyn Krieger |
Posted: May 28, 2010, 3 a.m. EST
Q: I have a 2 ½ year old neutered/ declawed Siamese cat. He bites the corners of all of our wood furniture throughout the house. Does he have some diet deficiency or is it a behavioral problem? My husband and I are both at home most of the day, and he gets a lot of attention. My girlfriend has a lot of cats on her farm and has never had any of them bite on furniture. She thinks it must be a diet deficiency.
A: From your description, it sounds like your cat is exhibiting a behavior called pica. This behavior needs to be taken seriously since biting, chewing and ingesting inedible objects such as the household furniture can result in life-threatening intestinal obstructions.Pica behaviors can be caused by a number of factors, including dietary, medical or behavioral. It is important that you take your cat to his veterinarian for an evaluation. Often, veterinarians will prescribe medication along with behavior modification for cats suffering with pica challenges. A credentialed cat behaviorist will be able to provide you with both management and behavior modification recommendations that should help focus your cat away from his furniture obsession. These include: providing your cat with other more acceptable items to chew, a consistent schedule, more environmental enrichment and play.
Start by providing your cat with other more acceptable items to chew, such as safe, dental chew toys or cat-safe chicken or turkey jerky. It is important that the jerky contains no spices of any kind. Environmental enrichment will help divert your cat away from his chewing obsession as well. Provide your cat with lots of interactive toys he can't chew and swallow such as TurboScratchers and other ball and tract toys. Puzzle boxes that he can't munch are also good to use, since treats and other favorite items can be hidden in them. Tall cat trees and lots of shelves located in different parts of the house will also help keep your cat occupied.
Putting your cat on a consistent schedule will also help refocus him away from eating the furniture. Feed him at the same times every day. If possible, feed him lots of small meals throughout the day. Timed feeding stations are commercially available that will dispense meals on a regularly timed basis. If he enjoys being groomed, then have regular grooming sessions every day at the same time. Typically, 2 ½ year old Siamese cats love to play. Use a fishing pole toy to engage your cat in at least two rigorous play sessions a day, once in the morning and another at night. Play in a way that imitates the hunt and will tire him out. Clicker training, a positive-based training method, can also help to focus your cat away from the furniture.
Tanya International
My cat as got all the thinks you are saying but he's still chewing on my wooden things and he keeps chewing throw cables as well iv moved all cables but he still get them and he as bite my fella and made him bleed won't can I do as he 1 year old
Judith International
Our 2yo Burmese female has started chewing - first noticed marks on backs of wooden kitchen chairs - head scratching wondering if we had a rat. Now have seen she has ripped at undersides of formal dining chairs covered in leather like fabric, as well as an antique piece or two we just noticed. She has large outdoor cage complex she uses a lot. She has indoor tower to play on with five scratching posts. She has a heated pod to go rest in. This cat lacks nothing. We close the cat door at night to her outdoor cages. We recently had an invasion of an 8ft python that bit my husband at 11pm in the dark and it was actually after the puss as a meal having gained entry through the cat door during the day we think. Any suggestions welcome to stop the timber chewing but I will take on board the idea of taking her to the vet to check teeth etc.
Marliese Whitewater, WI
My male neutered, one year old Domestic Short Haired cat is biting on two corners of my coffee table. At first I thought he was sharping his teeth but then I saw him actually biting the table. I am also a college student who goes to classes 4 days a week and works. What do you think I should do?
Carriespo7405 Darien, IL
Loved it it was very helpful.
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DAYVILLE, Conn. -- United Natural Foods Inc. here said last week it expects to gain between $160 million and $200 million in annualized revenue from once again becoming the primary supplier to Wild Oats Markets, Boulder, Colo., but the new business will come at a cost. During a conference call with industry analysts to discuss results for the first quarter ended Oct. 31, Steven Townsend, UNFI's chief executive officer and chairman of the board, said he expects to give an estimate of the ...
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Skip to comments.Sunnis and Sadr's Shiites make peace
Posted on 02/25/2006 11:01:07 AM PST by jmc1969
THE movement of Shiite cleric Moqtada al-Sadr, alleged to have played a role in the anti-Sunni violence over the last few days, publicly made peace with political and religious Sunni leaders overnight.
Four sheikhs from the Sadr movement made a "pact of honour" with the conservative Sunni Muslim Scholars Association, and called for an end to attacks on places of worship, the shedding of blood and condemning any act leading to sedition.
The agreement was made in the particularly symbolic setting of Baghdad's premier Sunni mosque Abu Hanifa where the Shiite sheikhs prayed under the guidance of Sunni imam Abdel Salam al-Qubaissi.
The meeting was broadcast on television and the religious leaders all "condemned the blowing up of the Shiite mausoleum of Samarra as much as the acts of sabotage against the houses of God as well as the assassinations and terrorisation of Muslims".
The statement made reference to the key concerns of both communities with the violent aftermath to the attack on the Samarra mausoleum which saw more than 119 people die.
The sheikhs condemned "those who excommunicate Muslims" a reference to the "takfireen" or Islamist extremists like Abu Musab al-Zarqawi who justify killing fellow Muslims by declaring them non-Muslims.
"It is not permitted to spill the Iraqi blood and to touch the houses of God," said the statement, adding that any mosques taken over by another community should be returned.
(Excerpt) Read more at sundaytimes.news.com.au ...
This could go really bad for Zarqawi if the Iraqis realize that he and his merry band of headhunters have the most to gain by causing violence.
terrorists unite...yiptie dooo
Monkeys make a pact and decide to fling shi* together in harmony.
Sadr should be dead.
Another failure.
From the article: The sheikhs condemned "those who excommunicate Muslims" a reference to the "takfireen" or Islamist extremists like Abu Musab al-Zarqawi who justify killing fellow Muslims by declaring them non-Muslims.
It's one of the first signs of Nationalism and it's a positive unless of course you're speaking from the DNC vantage or the Pat Buchanan wing of the Republican party.
a candle Bump
Shhh, here is a dirty little secret, not all Iraqis want us to leave.
The road to peace - if you can call it that in a Muslim land - runs over the graves of Sadr and Zarqawi .
Semper Fi
I suspect Sadr is in the pocket of the Iranians and Iranian agents actually blew up their gilded mud hut. It's all just a timely distraction so the Iranian mullahs can finish their A-bombs. Cartoons riots, Sunni/Shiite riots: don't pay any attention to the mullah behind the curtain.
LOL..the DNC is 'deeply saddened'
You knew we were in for a long slog when Bush refused to kill Al Sadr back in May 2003. Biggest mistake of the conflict.
"It's one of the first signs of Nationalism and it's a positive unless of course you're speaking from the DNC vantage or the Pat Buchanan wing of the Republican party."
An Iraqi Sunni Muslim shakes hand with a Shiite Muslim. AP photo
These sort of things make "strange bedfellows". I saw it first hand when I was in Iran during the revolution.
((Sadr should be dead.
Another failure.))
Yup. Should have taken out OBL when we had a chance in Tora Bora too.
Should have pumped a couple in Saddams head too when they found him.
How many GI deaths has this Al Sadr guy horseshit caused??
Should have been marshal law right after the fall of Baghdad too.
We could have killed Zarqawi (or at least have a good chance of doing so) before the war, but the fools in the State Department were worried about us scaring away some of our allies before the war by hitting Zarqawi.
And over the grave of that nutcase in Iran.
Here's the real deal:
"Iraq has a government and Sadr, who is a puppet of Iran,
is part of it"
Not so strange when you understand that the shiite and sunni families (and Kurds) are intermarried. These guys most probably have in-laws and cousins who belong to the other sect.
You nailed it--the most clear-thinking poster on the thread. Present company excepted...
Question is: How many of the then allies of the Ayatollah are still in favor after the departure of the Shah?
You are so correct. Hale Shoma?
Looks like it
you get a ten on Olympic scoring system of insights.
I found this part of the article interesting:
In fact, Sadr's office in Najaf issued a statement Saturday calling on his followers to eschew their trademark black uniforms.
"The order has been given to members of the Mehdi Army to no longer wear their black uniform, so that it not exploited by those who commit crimes," said the statement.
The statement added that those attacking mosques were "criminal bands with no links to the Sadr movement."
Khubam. : ) Hale shoma chetore?
Khubam, motshakeram. Haste nabasheen.
I for one continue to think the zman had arrangement to carry out the attack on the shia shrine in Sammara. Or perhaps some small group on the Iranian mullahs or VEVAR payroll. Never the less intersting observance.
err....um.....they also called for withdrawal of U.S. troops (presumably including those long-term bases), or did you miss that part?
Nice analysis, and i respect your opinion.
Al Sadr has been fighting American forces since this war's infancy, as have the Sunnis and Al Quaeda.
I find it odd that immediately after having the most important shrine is the Muslim world bombed, that Al Sadr wants to call truce.
I think it's pure BS and fog.
Something much deeper here.
Until i see Sunnis and Shiia come together in masses in the streets, in unison...i will keep my point of view.
Ah huh, all is well now, for the pigs have flown.
Thanks 8^-)
Yes. All those who are hoping for civil war and ensuing chaos will be quite saddened by this development.
You missed the 30,000 Sunnis and Shia that marched together yestersay?
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Residence Michelangiolo
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Historical Traveler Reviews Residence Michelangiolo Florence
Loved it!
We spent five nights at the Residence Michelangiolo, located on a beautiful tree-lined avenue. Recently meticulously and beautifully restored, this villa is extremely pleasing to the eye. When we were there Angela had received flowers for her birthday, and the bouquets were placed at the entry where we could all enjoy them.
Angela greeted us at the door and she made us feel welcome immediately. She showed us to our enormous room, which we estimated to be about 20 feet by 18 feet. The ceiling is very high as well. The decor is very tasteful and soothing. We had a kitchenette, which can be used to cook simple meals. It has two burners, pots and pans, and, of course, a collander for those who crave pasta but don't feel like going out. We were supplied with juice, water, pastries, tea and coffee and enjoyed having these in our room.
The villa is located about 200 yards from the Arno River, at the origin of Viale Michelangiolo. The road meanders into the hills above Florence, and there is a great view of the city from the Piazza Michelangiolo.
It took us only 15 minutes, walking along the river, to reach the Ponte Vecchio, the center of "tourist" Florence. There is also a very convenient bus that follows the same route.
We enjoyed our location very much. There is a cafe serving espresso, pastries, and sandwiches just down the road. A self-service laundry is nearby, and Angela cheerfully drove me there the first time when her simple instructions fell on deaf ears.
We would recommend this hotel to any of our friends, and would certainly stay there again.
Best Service
What a delight after four days in Paris and Rome to drive down Viale Michelangiolo amongst the most beautiful private residences in Florence to discover our residence awaiting us after a long day on the road.
Of our five different stops, this was the most gracious and the most value of any. The home is located very close to the river, within several minutes walking. The entrance gate is kept locked so we had a safe place to park at no extra fee.
Angela was happily awaiting our check in and I cannot say enough about her. She made us feel like we were home, offering water, shopping tips, maps, directions, even a spray for the car when we left! I had to make some changes in my plane reservations and she let me tie up her desk phone for at least twenty minutes (she did have a separate line) so incoming calls could be taken.
The rooms were very large with high ceilings and the beds most comfortable. Our room had tile floors and a beautiful terrace...lots of light, a phone, TV with American speaking news and a fully stocked kitchenette. One of our rooms had a FP. The baths were very clean and offered amenities one looks for when traveling.
Angela also recommended an excellent local restaurant which was one of the best we ate in the entire trip.
I would stay here in a second and highly recommend it for comfort, proximity, value and service.
The perfect place to stay in Florence
We satyed here for 3 nights in January & 1 night in Pisa. The accomodation is absolutely fantastic- we stayed in a double room with a cot for our 1.5yr old son, this was beautifully decorated, at least 2-3 times the size of a usual hotel room! The room was very warm & comfortable with a beautiful view out of the huge windows. The hotel owners were extremely nice & could not do enough to help. We were away for my wife`s birthday & even though none of us told them about it, on our last night we came back from our meal to find a bottle of bubbly & glasses awaiting us in our room! The hotel is approx 15 minute walk to the centre of Florence which should not put anyone off as it is a beautiful walk along the river. It is obvious a lot of time & money has been invested into the refurbishment, since the place has only opened August `05, it is unfair to call the Residence Michelangiolo a hotel because it is much more than that - self catering accomodation in a small mansion in a beautiful city.
I hope to be back again soon!
The best that could happen to us
we were in florence for the marathon and unfortunately the weather was quite awful.
but the staff in the hotel and the rooms were really nice and great.
we decided that if we come back to florence one time, the first hotel we will contact is this one.
A good choice, but not a perfect one
It's a nice, quite and well decorated house with very friendly and helpfull staff. Two things may not please everybody :
1. The breakfast. You have to make your own coffee in the kitchenette. There is a sad biscuit coming with it.
2. You can't receive calls after 6 pm, which is inconvinient for travellers who don't belief in mobile phones.
Fantastic place
we were at the residence Michelangelo for 3 days, it was fantastic. The rooms were big and beautifull, bathroom were clean as new, and the service are perfect.The people at the desck are exceptional, they are kind, nice, helpfull...we were welcome like familly members.So i realy recomande this place to any body that wants to spend nigths in florence with an atmosphere of that periode of time in an splendid envirment.
The Residence Michelangiolo is a jewel of a property.
The Residence Michelangiolo is a jewel of a property in a quiet residential area within a short walking distance to the center of Florence. There is also a bus stop only one block from the hotel offering frequent service to major tourist sites in Florence. The Residence is rated 3 stars but in our opinion it should be a 4.5 star rating. Each of the 11 rooms have been completely renovated with many guest comforts. The rooms are quite large and we found them to be extremely clean and nicely appointed. There is also parking on-site, inside a gated parking lot. Our group of six travelers were not only impressed with the facility, but also with the staff who could not have been more accomodating or professional. Angela and Barbara were very helpful in offering suggestions and directions to local eating establishments, city sites in Florence and finally, recommendations to wineries in nearby Tuscany.
I highly recommend this hotel to everyone. Ciao, Dennis De Sousa
A Florentine treasure!
Have just returned from a 4 night stay at the Residence Michelangiolo and cannot over emphasise what a wonderful find it is!
A beautiful period property, sympathetically restored and tastefully decorated with the warmest of welcomes from Angela and Barbara. Our room, on the first floor was far more spacious than many hotel rooms we have stayed in, with a most comfortable bed and everything we needed to prepare a simple breakfast to get us started for a day's sightseeing. It is situated on the tree lined road leading up to the Piazza Michelangelo and is about 15 minutes walk along the riverside to the historical centre.
I was a little apprehensive as I could find no reviews when I booked it, but it is brand new this season, having only opened in July and all my worries melted away as soon as we arrived.
So all I can say to those who might read this entry is to go ahead and book it and you will be assured of a beautiful and relaxing base, attended by the most delightful hosts. It is especially good for those who prefer a more relaxed start in the mornings in the privacy of your own room.
Hey Barbara and Angela, next time, could you also fix it so that the sun shines!!!
Beautiful place, great hospitality
We've just returned from a 3 night stay in this great place. Not only is it beautifully and sympathetically decorated, but the welcome offered is fabulous, without ever being intrusive or overbearing. Angela and Barbara are really sweet hosts, and never stopped smiling the entire time we were there. In addition, on our third night, (having been in Siena for a few days in the interim), we came home to find a bottle of Chianti and 2 glasses and a welcome back note.
It really is a find, and we will definitely go back!
Wonderful experience!
Our eight-day stay in this beautifully renovated charming Italian villa truly exceeded our expectations. From the moment we arrived (late in the evening), Barbara and Angela provided us with first rate service. Both the personal attention and beautifully quiet surroundings contributed to making this our best holiday experience ever. Our room, with a terrace overlooking the garden, was beautifully decorated. From the king-sized majestic bed in the bedroom (dressed in what could only be described as a custom-tailored Florentine golden textile dream) to the flower-shaped chandelier in the kitchen, no detail was spared when transforming this villa into a peaceful retreat.
Every morning, prior to our daily visits to the numerous museums and monuments Florence has to offer, we welcomed the sun via the graceful wooden terrace doors. Chatting over a nice cup of caf� latte, we prepared the day's itinerary. With Barbara's help and Angela's enthusiasm, we always knew what places to visit. From making our museum reservations to providing us with an umbrella when the weather was not cooperating, no detail escaped their attention. Even the weekend revealed its surprise: a complimentary bottle of Italian wine awaited us in our room as we returned from a hectic day of city touring. A lovely gesture from the staff, indeed. Needless to say, with memories like these our next trip to Residence Michelangiolo is in the making!
TripAdvisor Reviews Residence Michelangiolo Florence
Travel Blogs from Florence
Under a Tuscan Rain Cloud?
... city. As evening cleared we crossed a bridge not far from our hotel and enjoyed dinner at a small restaurant called Gattabuia. This we woud highly reccomend as a great place for a casual dinner or lunch with less of a tourist vibe. It features great food and friendly service in a cosy environment.
Tomorrow Pisa and ...
First class travels (with some funny families)
... up a conversation with us and basically said, "Birth control?" we laughed, established they were from LA and we carried on with our game of Rook. Throughout the trip we also overheard the family in the next 6 seats. They were from N. Carolina and a hilarious group. Sounded like a family traveling with Nana and poppa. Nana seemed to come with all the snacks in the world and wanted to share with the family (which drove Jenny nuts when no one would take the chips that she wanted ...
Florence Part 3 - his version
... did this come from?", she inquired about my shirt and tie.I looked at her and said "shhhh, let me do this!"So, I began by telling her that I love her. I love her smile, I love her laugh, I love her intelligence.I got down on one knee, and held up the open box with the ring I purchased for her perched in the center."Holly, will you marry me?"She couldn't wait to say yes, I slid the ring onto her finger, and I picked myself up and hugged ...
Italy - Florence
... pasta with a vegetable ragout sauce for lunch, and then supper was a tomato sauce with eggplant that was excellent. Mike had pasta for lunch also that we thought would have pepperoni in it as the name was similar but it was just a plain tomato sauce and then for supper he got pasta with a cheese sauce. Mmm so good. I've pretty much only have eaten pasta since we got to Italy. The city of Florence is quite pretty. Although I think we're about done with sight seeing and looking at ...
Pizza in Pisa?
... while trying to find our way out, we entered a flower garden. That was so beautiful! It over looked the city as well, and there were couples kissing and laying on blankets. It was so romantic and cute. We had dinner at a wonderful restaurant and I had my first hamburger in Italy! We ended the night with watching the sunset on the bridge over the river. It was absolutely beautiful and I loved every second of it. ( seeing how sunsets are my favorite thing in the whole ...


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News By Tag
Industry News
Industry News
SoleraTec Releases Version 6.3.3 Of Flagship Phoenix RSM Video Surveillance Management Software
Focusing On Speed, Performance, and Scalability Of An Extendable Retention Solution That Delivers Affordable Overarching Video Surveillance Management.
Some of the highlights of SoleraTec's Phoenix RSM 6.3.3 include:
∙ Bookmarks and Video Annotations
∙ Case Management capabilities
∙ Multi-stream video feed from supported IP-cameras
∙ Improved Milestone and OnSSI recording server support
∙ Windows Server 2012 R2 and FreeBSD support
∙ LTO-6 2.5-terabyte per cartridge storage support
One example of improved per-camera video feed processing is the SHA256 checksum –or digital fingerprint–
This new release also includes additional operating system support such as Windows Server 2012 R2 in both 32- and 64-bit modes.
"Phoenix RSM 6.3.3 provides the video surveillance community with a robust and feature-rich video management solution with overarching 'Lens to Library' support in a multi-tiered video storage environment,"
This release also includes new functionality allowing users to search a specific metadata search term across any and all database fields to greatly improve the relevant search results allowing users to more easily and quickly find the video of interest they are seeking.
Deeper integration with Milestone and OnSSI recording servers allow for improved longer-term video retention capabilities utilizing a multi-tiered storage infrastructure to significantly reduce video storage costs.
Another major upgrade to the Phoenix RSM solution is the new ability to process multiple video streams simultaneously from supported IP-cameras. This new ability will allow Phoenix RSM to pull an initial highest resolution possible video stream for long-term retention while at the same time pulling a low-resolution companion video stream for storage on local disk. This low-resolution companion file allows for fast search and video playback while reducing network bandwidth constraints and hard disk storage needs while being linked to the high-resolution original video for forensic and evidentiary needs.
For improved video investigation issues, Phoenix RSM now includes user-entered bookmarks that allow for the quick search of specific video of interest. Additional annotation of video for Case Management requirements provides an organizational tool to ease the burden of tracking video of interest to a specific case.
SoleraTec continues to lead the multi-tiered video storage market with Phoenix RSM and this latest version extends the capabilities, functionality, and value video operators and security professionals need in today's video surveillance management solutions.
Download an evaluation trial version of Phoenix RSM 6.3.3 at:
About SoleraTec
SoleraTec is a leading developer of archive, storage, and video lifecycle management products. SoleraTec leverages a heritage of over 15 years to deliver quality, innovation, and technological advancement that has established it as one of the premier data protection solution providers in the industry. SoleraTec works through OEMs, dealers, and system integrators to deliver complete video asset protection solutions. The company was established in 1997 by a team of industry veterans with experience deploying data protection, HSM, and storage lifecycle management solutions to some of the largest companies around the world. For more information, please visit www.SoleraTec.com.
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Argan & Peptide Wrinkle Repair Cream
A rejuvenating age defense daily moisturizer that helps diminish the appearance of fine lines and wrinkles.
Argan & Retinol Wrinkle Repair Night Cream
A moisture-rich, renewing night cream that helps visibly reduce the appearance of lines and wrinkles, without irritation.
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A nourishing moisturizer that helps visibly reduce the appearance of fine lines and wrinkles with firming Ginseng Complex.
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Calendula Essential Hydrating Cream
A nourishing, deeply moisturizing cream that softens and soothes dry, sensitive skin.
Cassis Ultra Replenishing Cream
A rich, vitamin-packed cream that helps visibly improve skin firmness, elasticity and radiance.
Daily Defense Moisturizer
A lightweight blend of protective antioxidants Vitamins A, C and E plus hydrating Aloe to promote a healthy-looking complexion.
Rosemary Oil-Reducing Moisturizer
A light, mattifying moisturizer that hydrates skin, absorbs oil and refines pores.
Vitamin C Revitalizing Lotion
An ultra-light daily moisturizer that helps prevent the visible signs of aging and helps improve elasticity.


text:
Smart bandage monitors wound condition
This sterile bandage contains embedded sensors that can transmit information from a wound to medical personnel. It could also begin delivering medicine while the wounded patient awaits treatment. This would be particularly useful in extreme accident cases where there are many victims and emergency responders must prioritise treatment.
These examples illustrate how interrelated design and function can be and reflects the belief of the Batelle Industrial Design group that design influences almost every object in our daily lives.


text:
Introduction to Microsoft Access 2000 Projects and the MSDEThis content is no longer actively maintained. It is provided as is, for anyone who may still be using these technologies, with no warranties or claims of accuracy with regard to the most recent product version or service release.
Acey Bunch
Microsoft Corporation
June 1999
Summary: This article lists the best sources of detailed information about Microsoft® Access projects (.adp files), which allow you to develop client/server database applications in Access by using either Microsoft SQL Server™ or Microsoft Data Engine (MSDE) as the back-end database (3 printed pages).
What Are Access Projects? What's the MSDE?
With the release of Microsoft Access 2000, an exciting new technology has been introduced—Access projects (.adp files), which allow you to develop true client/server applications from within the Access environment. Creating these project files differs from the traditional file-server development that Access developers have typically used, such as developing a database application with the Microsoft Jet database engine and saving all the database objects in a single .mdb file.
Like an .mdb file, an Access project file also allows you to develop a database application in the Access environment, but instead of using Jet, you're natively using either Microsoft SQL Server or the new Microsoft Data Engine (MSDE) as the back-end database. You can use an Access project to create an entirely new SQL Server or MSDE database, or to connect to an existing database. You then use tools in Access to create or modify the tables, relationships, views, stored procedures, and other database objects that are stored on your server, and create and save the client application objects (forms, reports, macros, and modules) that are stored in the .adp file.
Another cool thing about Access projects is that you can now develop a rich user interface for SQL Server or MSDE databases by using the familiar Access environment. For example, you can create forms, reports, macros, and modules just as with traditional Access applications. However, creating tables is a little different, and relationships are called database diagrams. In addition, there are new database objects that you can use, such as views, stored procedures, and data access pages. For data access, you can use ActiveX® Data Objects (ADO), which is a rich object model for accessing data from a variety of sources.
Where Do I Find More Information About Access Projects and the MSDE?
To start learning about Access projects, see the section "Working with Microsoft Access Projects" in the Contents tab of the Microsoft Access Help window, or go to the Office Assistant or the Answer Wizard tab and type client/server.
For the most up-to-date information about Access projects and the MSDE, see the Access Readme file, which is typically located at C:\Program Files\Microsoft Office\Office\Acread9.txt.
For additional information and resources, see the links in the following table.
|The new Office Developer Web site. Check here periodically for the latest information about developing Office applications.
|This page is all about the MSDE. From here you can read white papers, look at sample code, download the MSDE, and even order a CD-ROM that contains the MSDE and SQL Server 7.0 Developer edition.
|This is the Access 2000 Help and How-To page. This page contains links to Access 2000 tutorials, online discussion groups, and many other resources.
|This is the SQL Server Web site. Check here for the latest information about SQL Server and the MSDE.
|The Visual Basic 6.0 Resource Center: Book Excerpts: Beginning Visual Basic 6 Database Programming, Chapter 11. This chapter looks quickly at the historical background to the development of ADO before moving on to discuss more recent developments in data access technologies. Next,it explores the concepts and components of ADO itself before moving on to create the first pieces of code that will program ADO.
|This is the Microsoft Personal Support Center advanced search page. For step 1, select Access 2000; for step 2, select keywords; and for step 3, type MSDE. This query will bring up the latest Knowledge Base articles about using the MSDE.
|This is the home page for Microsoft Press®. Here you can find a multitude of titles covering Access, SQL Server, and Visual Basic® for Applications.


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Head over to the subscribers forum to get the latest updates from big league camp
Updates From Minor League Camp
Amazin Clubhouse Top Stories
Reyes, Cabrera spark Mets comeback winNew York ended a three-game skid and gave its fans a major reason to cheer on Thursday night.
Amazin Clubhouse09/22/2016
3-Stars of the Series: Mets vs. BravesThe Amazin's suffered a gut-wrenching loss on Wednesday night that saw them get swept at home by the lackluster Braves.
Amazin Clubhouse09/22/2016
3-Stars of the Series: Mets vs. TwinsAmazin' Clubhouse recaps a series sweep of the struggling Twins.
Amazin Clubhouse09/18/2016
3-Stars of the Series: Mets at NationalsNew York lost two out of three in the Nation's Capital, but still holds the second Wildcard spot in the National League.
Amazin Clubhouse09/15/2016


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24 Hours: TosaFest; Kite Festival; Food and Art Walk
6 p.m. Friday
TosaFest, one of the Milwaukee area's biggest free festivals, takes over the heart of Wauwatosa this weekend with lots of food, fun and music. »Read Full Article
Lollapalooza lineup coming Wednesday; 3-day passes sold out
All of the three-day passes for Lollapalooza in Chicago were gone less than 90 minutes after going on sale — and the lineup hasn't even been announced yet.
The major music festival, celebrating its 10th incarnation at Chicago's Grant Park from Aug. 1 to 3, will be headlined by Eminem,Skrillex,Kings of Leon and Arctic Monkeys,Chicago Tribune music critic Greg Kot reported last week. »Read Full Article(4)
Milwaukee Jewish educator tapped for 'Story of the Jews'
Local Jewish educator Ellie Gettinger was among a panel of experts who worked with filmmaker Simon Schama on his five-part series "The Story of the Jews," which begins tonight, airing locally on Milwaukee Public Television, Channel 10.
Gettinger is education director for the Jewish Museum Milwaukee. »Read Full Blog Post(1)
Lewis Black back in Milwaukee Oct. 10
Last time Lewis Black was in town, the hilariously irritated stand-up was headlining a comedy showcase at the 10,000 capacity BMO Harris Pavilion during last year's Summerfest.
The next gig will be much smaller in scale. Black will be back in Milwaukee on Oct. 10, performing material tied to his new stand-up show, "The Rant Is Due," at the Pabst Theater. »Read Full Article
On Tap Today: Paul McComas 'Unplugged'
Twelve years ago, Milwaukee native Paul McComas wrote the book "Unplugged," about a young musician and rape survivor trying to overcome depression and come to terms with her troubled childhood.


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|Preferred IUPAC name
Butanoic acid[1]
|Other names
Butyric acid[1]
1-Propanecarboxylic acid
Propanecarboxylic acid
C4:0 (Lipid numbers)
|EC Number
|Jmol 3D model
|Interactive image
Interactive image
|RTECS number
|UN number
|Molar mass
|88.11 g·mol−1
|Colorless liquid
|Unpleasant and obnoxious
|1.135 g/cm3 (−43 °C)[2]
0.9528 g/cm3 (25 °C)[3]
|Melting point
|Boiling point
|Sublimes at −35 °C
|Slightly soluble in CCl4[5]
Miscible with ethanol, ether
|log P
|Vapor pressure
|0.112 kPa (20 °C)[6]
0.74 kPa (50 °C)
9.62 kPa (100 °C)[4]
Henry's law
constant (kH)
|5.35·10−4 L·atm/mol[5]
|Acidity (pKa)
|Thermal conductivity
|1.46·105 W/m·K
Refractive index (nD)
|1.814 cP (15 °C)[7]
1.426 cP (25 °C)[5]
|Monoclinic (−43 °C)[2]
a = 8.01 Å, b = 6.82 Å, c = 10.14 Å[2]
α = 90°, β = 111.45°, γ = 90°
|178.6 J/mol·K[4][5]
Std molar
entropy (S
|222.2 J/mol·K[7]
Std enthalpy of
formation (ΔfH
|−533.9 kJ/mol[4]
Std enthalpy of
combustion (ΔcH
|2183.5 kJ/mol[4]
|Safety data sheet
|External MSDS
|GHS pictograms
|GHS signal word
EU classification (DSD)
|Xn C
|Flash point
|71 to 72 °C (160 to 162 °F; 344 to 345 K)[6][8]
|Explosive limits
|Lethal dose or concentration (LD, LC):
LD50 (median dose)
|2000 mg/kg (oral, rat)
|Related compounds
Other anions
Related Carboxylic acids
|Propionic acid
Acrylic acid
Succinic acid
Malic acid
Tartaric acid
Crotonic acid
Fumaric acid
Pentanoic acid
Related compounds
Methyl butyrate
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|verify (what is ?)
|Infobox references
Butyric acid (from Greek βούτῡρον, meaning "butter"), also known under the systematic name butanoic acid, abbreviated BTA,[6] is a carboxylic acid with the structural formula CH3CH2CH2-COOH. Salts and esters of butyric acid are known as butyrates or butanoates. Butyric acid is found in milk, especially goat, sheep and buffalo milk, butter, parmesan cheese, and as a product of anaerobic fermentation (including in the colon and as body odor). It is also found in milk chocolate produced by the Hershey process, or added to imitate the flavour of Hershey's chocolate.[9] Butyric acid is present in, and is the main distinctive smell of, human vomit.[10] It has an unpleasant smell and acrid taste, with a sweetish aftertaste similar to ether. Mammals with good scent detection abilities, such as dogs, can detect it at 10 parts per billion, whereas humans can detect it in concentrations above 10 parts per million.
Butyric acid was first observed in impure form in 1814 by the French chemist Michel Eugène Chevreul. By 1818, he had purified it sufficiently to characterize it. However, Chevreul did not publish his early research on butyric acid; instead, he deposited his findings in manuscript form with the secretary of the Academy of Sciences in Paris, France. Henri Braconnot, a French chemist, was also researching the composition of butter and was publishing his findings, and this led to disputes about priority. As early as 1815, Chevreul claimed that he had found the substance responsible for the smell of butter.[11] By 1817, he published some of his findings regarding the properties of butyric acid and named it.[12] However, it was not until 1823 that he presented the properties of butyric acid in detail.[13] The name of butyric acid comes from the Latin word for butter, butyrum (or buturum), the substance in which butyric acid was first found.
Butyric acid is a fatty acid occurring in the form of esters in animal fats. The triglyceride of butyric acid makes up 3–4% of butter. When butter goes rancid, butyric acid is liberated from the glyceride by hydrolysis, leading to the unpleasant odor. It is an important member of the fatty acid subgroup called short-chain fatty acids. Butyric acid is a medium-strong acid that reacts with bases and strong oxidants, and attacks many metals.[14]
The acid is an oily, colorless liquid that is easily soluble in water, ethanol, and ether, and can be separated from an aqueous phase by saturation with salts such as calcium chloride. It is oxidized to carbon dioxide and acetic acid using potassium dichromate and sulfuric acid, while alkaline potassium permanganate oxidizes it to carbon dioxide. The calcium salt, Ca(C4H7O2)2·H2O, is less soluble in hot water than in cold.
Butyric acid has a structural isomer called isobutyric acid (2-methylpropanoic acid).
Personal protective equipment such as rubber or PVC gloves, protective eye goggles, and chemical-resistant clothing and shoes are used to minimize risks when handling butyric acid.
Inhalation of butyric acid may result in soreness of throat, coughing, a burning sensation, and laboured breathing. Ingestion of the acid may result in abdominal pain, shock, and collapse. Physical exposure to the acid may result in pain, blistering and skin burns, while exposure to the eyes may result in pain, severe deep burns and loss of vision.[14]
It is industrially prepared by the fermentation of sugar or starch, brought about by the addition of putrefying cheese, with calcium carbonate added to neutralize the acids formed in the process. The butyric fermentation of starch is aided by the direct addition of Bacillus subtilis. Salts and esters of the acid are called butyrates or butanoates.
Butyric acid or fermentation butyric acid is also found as a hexyl ester hexyl butyrate in the oil of Heracleum giganteum (a type of hogweed) and as the octyl ester octyl butyrate in parsnip (Pastinaca sativa); it has also been noticed in skin flora and perspiration.
Butyric acid is used in the preparation of various butyrate esters. Low-molecular-weight esters of butyric acid, such as methyl butyrate, have mostly pleasant aromas or tastes. As a consequence, they are used as food and perfume additives. It is also used as an animal feed supplement due to the ability to reduce pathogenic bacterial colonization.[15] It is an approved food flavoring in the EU FLAVIS database (number 08.005).
Due to its powerful odor, it has also been used as a fishing bait additive.[16] Many of the commercially available flavors used in carp (Cyprinus carpio) baits use butyric acid as their ester base; however, it is not clear whether fish are attracted by the butyric acid itself or the substances added to it. Butyric acid was, however, one of the few organic acids shown to be palatable for both tench and bitterling.[17]
The substance has also been used as a stink bomb by Sea Shepherd Conservation Society to disrupt Japanese whaling crews,[18] as well as by anti-abortion protesters to disrupt abortion clinics.[19]
|This section is missing information about 2 additional metabolic pathways: [1]. (May 2015)
Butyrate is produced as end-product of a fermentation process solely performed by obligate anaerobic bacteria. Fermented Kombucha "tea" includes butyric acid as a result of the fermentation. This fermentation pathway was discovered by Louis Pasteur in 1861. Examples of butyrate-producing species of bacteria:
The pathway starts with the glycolytic cleavage of glucose to two molecules of pyruvate, as happens in most organisms. Pyruvate is then oxidized into acetyl coenzyme A using a unique mechanism that involves an enzyme system called pyruvate:ferredoxin oxidoreductase. Two molecules of carbon dioxide (CO2) and two molecules of elemental hydrogen (H2) are formed as waste products from the cell. Then,
|Responsible enzyme
|Acetyl coenzyme A converts into acetoacetyl coenzyme A
|acetyl-CoA-acetyl transferase
|Acetoacetyl coenzyme A converts into β-hydroxybutyryl CoA
|β-hydroxybutyryl-CoA dehydrogenase
|β-hydroxybutyryl CoA converts into crotonyl CoA
|Crotonyl CoA converts into butyryl CoA (CH3CH2CH2C=O-CoA)
|butyryl CoA dehydrogenase
|A phosphate group replaces CoA to form butyryl phosphate
|The phosphate group joins ADP to form ATP and butyrate
|butyrate kinase
ATP is produced, as can be seen, in the last step of the fermentation. Three molecules of ATP are produced for each glucose molecule, a relatively high yield. The balanced equation for this fermentation is
Several species form acetone and n-butanol in an alternative pathway, which starts as butyrate fermentation. Some of these species are:
These bacteria begin with butyrate fermentation, as described above, but, when the pH drops below 5, they switch into butanol and acetone production to prevent further lowering of the pH. Two molecules of butanol are formed for each molecule of acetone.
The change in the pathway occurs after acetoacetyl CoA formation. This intermediate then takes two possible pathways:
Highly-fermentable fiber residues, such as those from resistant starch, oat bran, pectin, and guar are transformed by colonic bacteria into short-chain fatty acids (SCFA) including butyrate, producing more SCFA than less fermentable fibers such as celluloses.[20] One study found that resistant starch consistently produces more butyrate than other types of dietary fiber.[21] The production of SCFA from fibers in ruminant animals such as cattle is responsible for the butyrate content of milk and butter.[22]
Fructans are another source of prebiotic soluble dietary fibers. They are often found in the soluble fibers of foods which are high in sulfur, such as the Allium and Cruciferous vegetables. Sources of fructans include wheat (although some wheat strains such as spelt contain lower amounts),[23] rye, barley, onion, garlic, Jerusalem and globe artichoke, asparagus, beetroot, chicory, dandelion leaves, leek, radicchio, the white part of spring onion, broccoli, brussels sprouts, cabbage, fennel and prebiotics such as fructooligosaccharides (FOS), oligofructose and inulin.[24][25] While many of these foods lack in butyrate production compared to resistant starch, they do have a number of benefits. They generally possess a low glycemic index which appeals well to diabetics. They also appeal to those on the ketogenic diet who benefit from beta-Hydroxybutyric acid, which is a HDAC inhibitor which can cross the blood brain barrier and be used as fuel in the mitochondria of brain cells.[26] Other HDAC inhibitors in these butyrate producing foods are sulforaphane,[27] which has promise in inhibiting human breast cancer cells.[28] Sulforaphane has also been shown to promote hair growth in mice,[29] it contains compounds which prevent ulcers,[30] and helps with cognitive function in rats.[31] It is good to note that sulforaphane in broccoli is destroyed if prepared improperly.[32] Diallyl disulfide found in the fructans containing garlic has been shown to reduce chemical toxicity and carcinogenesis in rodents,[33] and shows synergestic benefits with butyrate when it comes to inhibiting the growth of human cancer tumor cells in the colon.[34]
|Inhibited enzyme
|IC50 (nM)
|Entry note
|Lower bound
|Lower bound
|Lower bound
|Lower bound
|Lower bound
|GPCR target
|Entry note
|Full agonist
|Full agonist
|missing data
|Full agonist
Like other short chain fatty acids (SCFAs), butyrate is an agonist at the free fatty acid receptors FFAR2 and FFAR3, which function as nutrient sensors which help regulate energy balance; unlike the other SCFAs, butyrate is also an agonist of niacin receptor 1. Butyric acid is also utilized by mitochondria, particularly in colonocytes, to generate adenosine triphosphate (ATP) during fatty acid metabolism. Butyric acid is also an HDAC inhibitor (specifically, HDAC1, HDAC2, HDAC3, and HDAC8), a drug that inhibits the function of histone deacetylase enzymes, thereby favoring an acetylated state of histones in cells. Acetylated histones have a lower affinity for DNA than nonacetylated histones, due to the neutralization of electrostatic charge interactions. In general, it is thought that transcription factors will be unable to access regions where histones are tightly associated with DNA (i.e., nonacetylated, e.g., heterochromatin). Therefore, butyric acid is thought to enhance the transcriptional activity at promoters, which are typically silenced or downregulated due to histone deacetylase activity.
|This section needs expansion. You can help by adding to it. (May 2015)
Butyric acid is metabolized by various human XM-ligases (ACSM1, ACSM2B, ASCM3, ACSM4, ACSM5, and ACSM6), also known as butyrate–CoA ligase.[10] The metabolite produced by this reaction is butyryl–CoA, and is produced as follows:[10]
As a short chain fatty acid, butyrate is utilized by mitochondria as an energy (i.e., adenosine triphosphate or ATP) source through fatty acid metabolism.
In humans, the butyrate prodrug tributyrin is metabolized by triacylglycerol lipase into dibutyrin and butyrate through the reaction:[37]
Butyrate has numerous beneficial effects in humans on energy homeostasis and related diseases (diabetes and obesity), inflammation, and immune function (e.g., it has pronounced antimicrobial and anticarcinogenic effects).[38][39] These effects occur through its utilization by mitochondria to generate ATP during fatty acid metabolism or through one or more of its histone-modifying enzyme targets (i.e., the class I histone deacetylases) and G-protein coupled receptor targets (i.e., FFAR2, FFAR3, and NIACR1).[38]
Butyrate's effects on the immune system are mediated through the inhibition of class I histone deacetylases and activation of its G-protein coupled receptor targets: NIACR1 (GPR109A), FFAR2 (GPR43), and FFAR3 (GPR41).[40][41] Among the short-chain fatty acids, butyrate is the most potent promoter of intestinal regulatory T cells in vitro and the only one among the group that is an NIACR1 ligand.[41] It has been shown to be a critical mediator of the colonic inflammatory response. It possesses both preventive and therapeutic potential to counteract inflammation-mediated ulcerative colitis and colorectal cancer.
Butyrate has established antimicrobial properties in humans that are mediated through the antimicrobial peptide LL-37, which it induces via HDAC inhibition on histone H3.[40][42][43] Butyrate increases gene expression of FOXP3 (the transcription regulator for Tregs) and promotes colonic regulatory T cells (Tregs) through the inhibition of class I histone deacetylases;[40][41] through these actions, it increases the expression of interleukin 10, an anti-inflammatory cytokine.[40][41] Butyrate also suppresses colonic inflammation by inhibiting the IFN-γ–STAT1 signaling pathways, which is mediated partially through histone deacetylase inhibition. While transient IFN-γ signaling is generally associated with normal host immune response, chronic IFN-γ signaling is often associated with chronic inflammation. It has been shown that butyrate inhibits activity of HDAC1 that is bound to the Fas gene promoter in T cells, resulting in hyperacetylation of the Fas promoter and up-regulation of Fas receptor on the T-cell surface.[44] It is thus suggested that butyrate enhances apoptosis of T cells in the colonic tissue and thereby eliminates the source of inflammation (IFN-γ production).[44]
Similar to other NIACR1 agonists, butyrate also produces marked anti-inflammatory effects in a variety of tissues, including the brain, gastrointestinal tract, skin, and vascular tissue.[45][46][47][48] Butyrate binding at FFAR3 induces neuropeptide Y release and promotes the functional homeostasis of colonic mucosa and the enteric immune system.[49]
Butyric acid is important as an energy (ATP) source for cells lining the mammalian colon (colonocytes). Without butyric acid for energy, colon cells undergo upregulated autophagy (i.e., self-digestion).[50]
Butyrate produces different effects in healthy and cancerous cells; this is known as the "butyrate paradox". In particular, butyrate inhibits colonic tumor cells and promotes healthy colonic epithelial cells.[51] The signaling mechanism is not well understood.[52] A review suggested that the chemopreventive benefits of butyrate depend in part on the amount, time of exposure with respect to the tumorigenic process, and type of fat in the diet.[20] The production of volatile fatty acids such as butyrate from fermentable fibers may contribute to the role of dietary fiber in colon cancer.[20] Short-chain fatty acids, which include butyric acid, are produced by beneficial colonic bacteria (probiotics) that feed on, or ferment prebiotics, which are plant products that contain adequate amounts of dietary fiber. These short-chain fatty acids benefit the colonocytes by increasing energy production and cell proliferation, and may protect against colon cancer.[53]
Conversely, some researchers have sought to eliminate butyrate and consider it a potential cancer driver.[54] Studies in mice indicate it drives transformation of MSH2-deficient colon epithelial cells.[55] It is important to note that these are related to a gene deficiency. Niacin, beta-hydroxybutyrate, and curcumin may be effective adjunct treatments if genetic issues are present.[56]
A review on the relationship between the microbiome and diabetes asserted that butyrate can induce "profound immunometabolic effects" in animal models and humans with type 2 diabetes;[39] it also noted a relationship between the presence of obesity or diabetes and a state of marked dysbiosis in a host, which is not yet completely understood.[39] While acknowledging that there is strong evidence for the use of butyrate in such disorders, the review called for more research into the pathophysiology (i.e., biomolecular mechanisms) of these diseases, so as to improve therapeutic approaches to these diseases.[39]
The observation of a large number of downregulated genes after methamphetamine withdrawal is consistent with previous results showing that methamphetamine can cause increased expression of histone deacetylases (HDACs) in the nucleus accumbens and the dorsal striatum. Butyric acid is a HDAC inhibitor.[65] HDACs are enzymes that can cause histone deacetylation and repression of gene expression. HDACs are important regulators of synaptic formation, synaptic plasticity, and long-term memory formation. Several HDACs also appear to play significant roles in various models of drug abuse and addiction.[66] The local knockout of HDAC1, as well as chronic and continuous infusion of MS-275, a pharmacological inhibitor highly selective in vitro for HDAC1, has been found with NAc suppressed cocaine-induced locomotor sensitization in mice.[67] HDAC3 inhibitor RGFP966 has been shown to facilitate the extinction of cocaine-seeking behavior and prevent reinstatement of cocaine-conditioned place preference in mice.[68] Histone deacetylase inhibitors have been shown to decrease cocaine, but not sucrose, self-administration in rats.[69] The beneficial bacteria that ferment probiotics and prebiotics to produce butyric acid have been shown to regulate behavior by means of the vagus nerve.[70]
Studies in rodents have found that the environment exerts an influence on epigenetic changes related to cognition, in terms of learning and memory;[71] environmental enrichment is correlated with increased histone acetylation, and verification by administering histone deacetylase inhibitors induced the sprouting of dendrites, an increased number of synapses, and reinstated learning behaviour and access to long-term memories.[72][73] Research has also linked learning and long-term memory formation to reversible epigenetic changes in the hippocampus and cortex in animals with normal-functioning, undamaged brains.[73][74] In human studies, post-mortem brains from Alzheimer's patients show increased histone de-acetylase levels.[75][76]
This article incorporates text from a publication now in the public domain: Chisholm, Hugh, ed. (1911). "Butyric Acid". Encyclopædia Britannica (11th ed.). Cambridge University Press.
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Short-chain fatty acids (SCFAs) such as acetate, butyrate, and propionate, which are produced by gut microbial fermentation of dietary fiber, are recognized as essential host energy sources and act as signal transduction molecules via G-protein coupled receptors (FFAR2, FFAR3, OLFR78, GPR109A) and as epigenetic regulators of gene expression by the inhibition of histone deacetylase (HDAC). Recent evidence suggests that dietary fiber and the gut microbial-derived SCFAs exert multiple beneficial effects on the host energy metabolism not only by improving the intestinal environment, but also by directly affecting various host peripheral tissues.
Recent studies have suggested that gut bacteria play a fundamental role in diseases such as obesity, diabetes and cardiovascular disease. Data are accumulating in animal models and humans suggesting that obesity and type 2 diabetes (T2D) are associated with a profound dysbiosis. First human metagenome-wide association studies demonstrated highly significant correlations of specific intestinal bacteria, certain bacterial genes and respective metabolic pathways with T2D. Importantly, especially butyrate-producing bacteria such as Roseburia intestinalis and Faecalibacterium prausnitzii concentrations were lower in T2D subjects. This supports the increasing evidence, that butyrate and other short-chain fatty acids are able to exert profound immunometabolic effects.
The establishment of a link between light therapy, vitamin D and human cathelicidin LL-37 expression provides a completely different way for infection treatment. Instead of treating patients with traditional antibiotics, doctors may be able to use light or vitamin D [291,292]. Indeed using narrow-band UV B light, the level of vitamin D was increased in psoriasis patients (psoriasis is a common autoimmune disease on skin) [293]. In addition, other small molecules such as butyrate can induce LL-37 expression [294]. Components from Traditional Chinese Medicine may regulate the AMP expression as well [295]. These factors may induce the expression of a single peptide or multiple AMPs [296]. It is also possible that certain factors can work together to induce AMP expression. While cyclic AMP and butyrate synergistically stimulate the expression of chicken β-defensin 9 [297], 4-phenylbutyrate (PBA) and 1,25-dihydroxyvitamin D3 (or lactose) can induce AMP gene expression synergistically [294,298]. It appears that stimulation of LL-37 expression by histone deacetylase (HDAC) inhibitors is cell dependent. Trichostatin and sodium butyrate increased the peptide expression in human NCI-H292 airway epithelial cells but not in the primary cultures of normal nasal epithelial cells [299]. However, the induction of the human LL-37 expression may not be a general approach for bacterial clearance. During Salmonella enterica infection of human monocyte-derived macrophages, LL-37 is neither induced nor required for bacterial clearance [300].
Specific species that have been recognized by their high levels of butyrate production include Faecalibacterium prausnitzii and the cluster IV and XIVa of genus Clostridium ... Administration of acetate, propionate, and butyrate in drinking water mimics the effect of Clostridium colonization in germ-free mice, resulting in an elevated Treg frequency in the colonic lamina propria and increased IL-10 production by these Tregs (180, 182). Of the three main SCFAs, butyrate has been found to be the most potent inducer of colonic Tregs. Mice fed a diet enriched in butyrylated starches have more colonic Tregs than those fed a diet containing propinylated or acetylated starches (181). Arpaia et al. tested an array of SCFAs purified from commensal bacteria and confirmed butyrate was the strongest SCFA-inducer of Tregs in vitro (180). Mechanistically, it has been proposed that butyrate, and possibly propionate, promote Tregs through inhibiting histone deacetylase (HDAC), causing increased acetylation of histone H3 in the Foxp3 CNS1 region, and thereby enhancing FOXP3 expression (180, 181). Short-chain fatty acids partially mediate their effects through G-protein coupled receptors (GPR), including GPR41, GPR43, and GPR109A. GPR41 and GPR43 are stimulated by all three major SCFAs (191), whereas GPR109A only interacts with butyrate (192).
Neuroinflammatory cells express HCA2, a receptor for the endogenous neuroprotective ketone body β-hydroxybutyrate (BHB) as well as for the drugs dimethyl fumarate (DMF) and nicotinic acid, which have established efficacy in the treatment of MS and experimental stroke, respectively. This review summarizes the evidence that HCA2 is involved in the therapeutic effects of DMF, nicotinic acid, and ketone bodies in reducing neuroinflammation.
As GPR109A's primary pharmacological ligand in clinical use, niacin has been used for over 50 years in the treatment of cardiovascular disease, mainly due to its favourable effects on plasma lipoproteins. However, it has become apparent that niacin also possesses lipoprotein-independent effects that influence inflammatory pathways mediated through GPR109A.
HCA2 is highly expressed on immune cells, including macrophages, monocytes, neutrophils and dermal dendritic cells, among other cell types. ... Recent studies demonstrate that HCA2 mediates profound anti-inflammatory effects in a variety of tissues, indicating that HCA2 may be an important therapeutic target for treating inflammatory disease processes.
GPR109A and its agonists are known to exert anti-inflammatory actions in the skin, gut and retina.
In the context of this review it is particularly worth noting that short chain fatty acids such as butyrate, which the colonic microbiota generates by fermentation of otherwise indigestible dietary fibre (Cherbut et al. 1998), stimulate L cells to release PYY via the G-protein coupled receptor Gpr41 (Samuel et al. 2008). In this way, short chain fatty acids can indirectly attenuate gastrointestinal motility as well as electrolyte and water secretion (Cox 2007b). More importantly, short chain fatty acids exert homeostatic actions on the function of the colonic mucosa and immune system (Hamer et al. 2008, Tazoe et al. 2008, Guilloteau et al. 2010, Macia et al. 2012a, Smith et al. 2013). Whether PYY plays a role in these effects of short chain fatty acids awaits to be investigated, but may be envisaged from the finding that PYY promotes mucosal cell differentiation (Hallden & Aponte 1997).
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Figure 1
ΔFosB serves as one of the master control proteins governing this structural plasticity.
The 35-37 kD ΔFosB isoforms accumulate with chronic drug exposure due to their extraordinarily long half-lives. ... As a result of its stability, the ΔFosB protein persists in neurons for at least several weeks after cessation of drug exposure. ... ΔFosB overexpression in nucleus accumbens induces NFκB
|Wikimedia Commons has media related to Butyric acid.


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Victor Gischler's Blogpocalypse
(cyber home of an author-ish sort of guy)
Thursday, June 30, 2016
There is actually no point at all to this blog post except to talk about Epcot. Why? Because I like Epcot. It's really that simple. It's my favorite of the Disney parks in Orlando. My good pal author Anthony Neil Smith tells me Epcot is his least favorite park because it is woefully out of date and showing it's age. I don't completely agree with this, but I do see his point when I'm over by the 3D show (are they still reviving Captain Eo?) and that terrible Figment imagination ride. So, yeah, I get it.
But the reason I love Epcot more than the other parks (although I like them too) is that as I am now squarely into middle age (which may or may not have anything to do with it) I find that I am much more about relaxation and entertainment than I am about rides. I mean, I like the rides, and I wouldn't want to leave Epcot without hitting Test Track and Soarin', but I'm much more keen to wander at a slow crawl around the World Showcase with a beer in my hand, taking in the entertainment.
I was sorry to hear that Canada's rock-n-roll bagpipe and kilt band (I don't remember their actual name) had moved on. Used to love those guys. But there is still plenty of good entertainment opportunities around the World Showcase. A mariachi band in Mexico sounds a little corny and cliché, but why not while you're enjoying a cold Mexican beer? In China they have acrobats. There are street performers in the UK and a British Invasion band at the rear of the pavilion. The band shell across from the American Experience usually has something going on. The Japanese drum show is cool. I like to start around lunch time, make an afternoon of it, and then finish before the wave of evening tourists. Staying through dinner is a good option, but often I leave before then.
And when Epcot hosts the Food & Wine Festival, you can crank the whole experience up to eleven.
The last time I was in Epcot I was all by myself (I was there to run a 5k) so I eased through the World Showcase at my own pace, taking it in at my leisure and NOT standing in line for an hour for rides. So ... like I said. No real burning need for this blog post. No amazing insights. I just like Epcot.
Posted by Victor Gischler at 5:36 AM 9 comments:
Monday, June 20, 2016
In the film racket, "stupid" and "hopeful" probably look the same from a distance.
What do I mean by that? I guess what I mean is that most writers know getting his/her work made into a film is a long shot. Such a long shot that putting any time or energy into it probably seems ... well ... stupid. And yet writers do it all the time. Are we stupid? Hopeful? Both?
Example: A few months ago I put the scripts for all five issues of my creator-owned comic Sally of the Wasteland into a single file and then dumped that file into Final Draft the popular "industry standard" screenwriting program. I would like to say that the program instantly transformed the comic book scripts into a film screenplay, but that would be a whopper of a lie. Still, if you squinted just right, the document did look a tiny bit screenplay-ish. I spent some time (time I should have been spending on other projects ... because I'm stupid and hopeful) hammering the thing into shape, making it look less like a comic book script and more like a screenplay.
It worked. After all my efforts, I sat back and looked at what I'd done. A 90 page feature screenplay. Cool. So .... now what?
At the time of writing this blog post, three of my novels are currently under option. I'm grateful for this, but all of these projects are happening "way over there" and I don't really feel connected to them at all. I'm keen to be hands on, so maybe Sally is my chance. Maybe. Who knows?
I hooked up with a like-minded fellow (I won't out him here in case he does not want to be thought of as stupid and hopeful) who liked the script and did a break down. We've discussed casting and funding and all that. It's all in the very early stages. As a comic, we billed Sally as "B-movie" and "grindhouse" and I'd love to approach the film version the same way. This could all end up being a stupid waste of time, but if I shunned everything difficult or unlikely, I'd never get anywhere. I guess that's the point. Hey, Gischler, you're wasting your time. Yeah? You might be right. I think I'm going to hit my head against this brick wall anyway.
In the meantime, Sally of the Wasteland still exists as a graphic novel. Check it out HERE.
Posted by Victor Gischler at 6:24 AM No comments:
Friday, June 3, 2016
This is how I pay the bills.
So in order to pay the mortgage, I feel obligated to harass you fine people every now and then into spending some money. I've been mostly pimping my fantasy trilogy recently since that's my latest thing, but just to mix it up, let's reach into the bag of forgotten stuff.
My first novel was Gun Monkeys, and it was nominated for an Edgar Award. After being published by the fine folks at UglyTown, Bantam Dell picked up mass market and eBook rights. I found out recently that the book has finally earned out after a 39 dollar check arrived in the mail. BIG BUCKS. So if you want to see the book that got me started, well, have a look maybe.
Posted by Victor Gischler at 10:55 AM 7 comments:
Sunday, February 7, 2016
Friday, January 29, 2016
Thursday, January 28, 2016
It's been a little over a week since A Painted Goddess was published, completing the epic fantasy trilogy A Fire Beneath the Skin, the story of young Rina Veraiin who is gifted with magical tattoos that give her extraordinary powers. Three novels full of magic, sword stabbings and steamy romantical whatnot. Check out the trilogy HERE.
The feedback has been awesome so far, and I am hugely grateful to all my readers. You guys rock and/or roll.
This is the part of the process where I come to you hat in hand and ask, "If you really liked the books, please consider writing a short honest review." And I hope you do. Reviews help authors. You don't have to do this. Obviously. That you read the books is already pretty cool. So I wouldn't put you on the spot to do more. But if you felt like leaving a review ...
And a few quick updates: For those asking if I will return to the world of Helva for more books, yes, I'd love to. I have PLENTY of ideas. It just depends on how well this trilogy sells. Ink Mage sold very, very well. We're waiting to see if the other two books catch up. Fingers crossed. For those asking about a paperback version of A Painted Goddess, the answer is yes. It's coming in March. Audio book? Yes, that's on the way too.
I've enjoyed writing these books immensely. Again, thanks for reading.
Posted by Victor Gischler at 6:18 AM 1 comment:
Sunday, January 17, 2016
A FIRE BENEATH THE SKIN ... almost finished!
A PAINTED GODDESS hits Kindles Tuesday, January 19, meaning the epic adventure that began with INK MAGE will reach it's exciting conclusion. Keep in mind, A Fire Beneath the Skin is a trilogy, yes three novels but all one big story. So if you're not a reader yet then get started HERE with book one. If you're already caught up with the first two books, then it's time to order A PAINTED GODDESS!
As a writer, it has been a long time dream for me to write a fantasy trilogy. I'm glad I was able to finally achieve this ambition, and Ink Mage is my most read novel. Readers are still steadily ordering the sequel and pre-ordering the final book. I'm hugely grateful to all of you out there.
Posted by Victor Gischler at 6:16 AM 2 comments:
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[WOMEN'S COACHING MOVES]Thirty Division I women's programs have replaced their head coach or are in the process of doing so. The moves include two New York metropolitan area programs that picked coaches from neighboring schools.The vacancy everyone is waiting to see filled is at Notre Dame, where Randy Waldrum left to become the coach of the NWSL's Houston Dash.
Women's Coaching Moves
Buffalo out: Michael Thomas; in:Shawn Burke (Buffalo assistant)
Campbellout: Todd Clark; in:Stuart Horne (Elon associate)
Cleveland State out: Derrek Falor; in:Sonia Curvelo (Mississippi Valley State)
Columbia out: Kevin McCarthy; in:Tracey Bartholemew (LIU)
CSU Bakersfield out:Melissa Phillips; in: TBA.
Eastern Washington out: George Hageage; in:Chad Bodnar (Walla Walla CC)
Fairleigh Dickinson out: Rick Stanton (Seton Hall); in:TBA.
Fordham out: Ness Selmani; in:Jessica Clinton (Boston Univ. associate)
Gardner-Webb out: Kevin Mounce; in:Mike Varga (Gardner-Webb assistant)
Idaho out: Peter Showler; in:TBA.
Iowa State out: Wendy Dillinger; in:Tony Minatta (Iowa State assistant)
LIU out: Tracey Bartholemew (Columbia); in:TBA.
Loyola, Md.out: Katerine Vittori; in:TBA.
Mississippi Valley State out: Sonia Curvelo (Cleveland State); in:TBA.
Murray State out: Beth Acreman; in:Jeremy Groves (Morehead State assistant)
New Mexico State out:Blair Quinn; in: Freddy Delgado (New Mexico State assistant)
North Florida out: Linda Hamilton; in:Robin Confer (Georgia assistant)
Notre Dame out:Randy Waldrum (Houston Dash); in:TBA
Old Dominion out: Joe Pereira; in:TBA.
Providenceout: Jim McGirr; in:TBA.
San Jose State out: Jeff Leightman; in:Lauren Hanson (Oregon assistant)
Seton Hall out: Kazbek Tambi; in:Rick Stanton (Farleigh Dickinson)
Tennessee Tech out: Daniel Brizard; in:Steve Springthorpe (Duke assistant)
Texas Southern out: Tamura Crawley-Marigny; in:TBA.
Troyout: Chris Bentley (Colorado State assistant); in:Jason Hamilton (Florida assistant).
UC Davis out: Maryclaire Robinson; in:Twila Kaufman (Pepperdine associate)
UNC Greensboro out:Steve Nugent;in:TBA
USC out:Ali Khosroshahin; in: Keidane McAlpine (Washington State).
Villanova out: John Byford; in:Fran Kulas (Villanova assistant)
Washington State out: Keidane McAlpine (USC); in: Steve Nugent (UNC Greensboro)


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Greeley should pay less for gas
Wondering if these oil and gas activities in Greeley are such a great thing why our gas price keep going up? I realize we need the boon in employment, but why do we see our gas prices keep escalating?
We should actually be paying less than other cities and states where there is not oil and gas activity, right? Let's address this issue. There is a lot of poverty in Greeley, and we could use a break in gas prices.
Mary L. Gonzales, Greeley


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Art, Music, and Alcohol Appreciation
Downtown Delray Beach will be an open-air art gallery on Thursday, with four-by-six-foot gallery walls set up along six blocks. Show up in the evening and you'll get to ogle and analyze works by 20 selected artists while taking in live music and guzzling alcohol (if that's your thing). The occasion is Arts, Beats, & Eats -- the art fair formerly known as Art & Jazz on the Avenue. It's been reinvented after 17 years to spotlight cutting-edge contemporary art of the sort found at Art Basel. The live music has been broadened to include stylings from three continents: North America, South America, and Europe, with each region represented by two live bands. And let's talk about alcohol. If you buy a wristband, you'll get free tastings at six bars set up along the street and 50 percent off cocktails -- on top of major discounts at three downtown restaurants and a bunch of shops and boutiques. The proceeds benefit a nonprofit, Shuzz, that provides shoes to the poor worldwide.
Arts, Beats, & Eats on Thursday from 6 to 10 p.m. in downtown Delray Beach on Atlantic Avenue. Admission is free. Wristbands cost $20. Visit downtowndelraybeach.com/arts-beats-eats.
Thu., Aug. 18, 6 p.m., 2011
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Top Definition
A soose Is someone that screws everything up 24/7 365
Dr.Seuss was a little soose when he dropped the glass.
by Gettingrealinthefield March 06, 2015
Trending Now
Can you define these popular missing words?
SOOSE is the acronym for "Sudden Onset Of Shit Episode," whereupon one is overcome by the sudden NEED to shit. This necessitates the urgent, often frantic, need to find a toilet, ASAP, or risk uncontrolled evacuation of one's bowels in whatever one is wearing at that moment. Often accompanied by growling of the lower bowels, and diarrhea.
Roger had a SOOSE, but made it to a toilet in time.
by Whistle Berries July 20, 2011
A slang term used to describe a "dirty girl".
A shortened version of the spanish word 'sucia' pronounced sue-see-ah
A shortened version of the spanish word 'sucia' pronounced sue-see-ah
Gina is a soose, she sleeps with a different guy every night of the week.
by Beckarinaxx August 24, 2009


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|Boxing Champions | Boxing Schedule | Boxing Video | Boxing History | Pound For Pound | Lounge | The Wire | Arcade
Big Bad Booty Daddy
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Comments Thread For: Klitschko vs. Solis? Tyson Fury is Ready To Fight
As BoxingScene.com reported several days go, IBO/IBF/WBA/WBO heavyweight champion Wladimir Klitschko (59-3, 50KOs) is looking to make a voluntary defense of the title on April 6th. The WBA had ordered Wladimir to make a defense against "regular" champion Alexander Povetkin (25-0, 17KOs), but Klitschko's side have already submitted their request to make a voluntary.
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I wouldn't mind a Wlad v Solis fight as long as Solis comes in the same shape he did against big bro without the injury (heard the injury was something he'd been carrying). Fury and Price are not ready.
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Would rather see Wlad vs Fury at this stage.
As much as I dislike Fury I have to be honest, I don't feel many deserve a crack more.
If Solis got into decent shape & got a meaningful win or two under his belt, that could be a great fight.
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This is disgusting. That slug has done nothing to deserve a second chance. This is worse than Wach.
Latin From Manhattan
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I wasn't about to put it quite so boldly, Cliff, but we're definitely thinking along the same lines. Solis was lucky to have gotten a shot at Vitali so soon into his pro career. Now he might get a shot at Wlad after only one fight back from the injury? It's a joke.
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WTF, Solis?
Please, no. God, NO!
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I am not happy with Solis at all! Hope it's not true. It would be a complete waste of time for Wlad. Solis is pretty much nobody. Fury is so much better option.
Ph.D in the Sweet Science
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Wow. The heavyweight division truly is a joke right now. Surely Wlad can find a better opponent?
What about Boytsov?
..Playa by Nature..
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I had high hopes for solis and he did well against vitali before he twisted his knee but the little buzz he enjoyed after that fight has completely vanished for me
i'd much rather see wlad take out trash talk fury...I don't think fury is going to improve any more than he has now that he's been getting himself in shape and wlad fought a much more exciting fight against wach who was also taller than he is, he fought at a higher pace as well
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If Wlad is really trying to fight Solis instead of Povetkin, that would be flat out disgraceful, whether Povetkin wants it or not. Solis doesn't deserve that shot, that's terrible.
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- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


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Just read entire writing. Main point is that BB&T under reserved bad loans by 20% in second quarter. They sold $251 million dollars worth of properties for $61 million less than reserved. Other banks doing the same. Also said that no appraisals are more than six months old now. That is a positive for me.Still think that BB&T is one of the best banks out there but that isn't saying much. Might be a couple of years before we see real improvement.
That WSJ article is only available to paid subscribers.USBanker has an interesting article that they have made available to everyone, not just their paid subscribers."Time to Sell Sour Loans? BB&T and PNC Say 'Yes'"July 2010http://www.americanbanker.com/bulletins/-1023010-1.htmlThe article is neutral in tone but with a lot of facts. Rather than risk copyright issues, and that no one paragraph gives enough to supplant the value of reading the entire article, I have chosen to not copy and paste any part here.
deros:Very good posting. As I said before, BB&T is the best of a very sorry banking industry. If the market tanks it will be because of the banks.Appreciate all the comments.
Don't know how to post. Sorry!The article is on page C10 of today's WSJ.
Can you post the article?