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Park Regis Anchorage
Park Regis Anchorage
Hotel Guest Rating: 8.2/10
51 Palmer Street
Townsville 4810
Park Regis Anchorage
Located in the entertainment and dining centre of Townsville, this 4-star hotel features 2 swimming pools, a restaurant and BBQ facilities. All accommodation is air-conditioned and includes cable TV and 250 MB of free WiFi daily. The property is 3 km from the Magnetic Island Ferry Terminal.Each of the spacious rooms, studios and apartments include private bathroom facilities, tea/coffee making supplies and a refrigerator. Some accommodation is self-contained with a fully equipped kitchen or a private balcony offering stunning views.Park Regis Anchorage allows immediate access to restaurants, cafés, bars, city nightlife and the Jupiters Casino. The hotel is also ideally set for a day visit to the world-famous Great Barrier Reef. Return from a busy day and relax by the outdoor pool with a refreshing drink.Townsville's easy-going lifestyle and activities include water sports, cruises, golf, fishing and rainforests and national park tours. ...read more
- Internet services
- Outdoor pool
- Free parking
Park Regis Anchorage Amenities
- Air conditioning
- BBQ facilities
- Family rooms
- Fax/photocopying
- Free parking
- Free WiFi
- Internet services
- Laundry
- Non-smoking rooms
- On-site parking
- Outdoor pool
- Parking
- Swimming pool
- Tour desk
- WiFi
Hotel Information
A credit card guarantee is required at time of booking. Please note that the first night of accommodation will be charged on your card by the hotel at 14:00 on the day of your arrival, and the remainder will be processed upon check-in. All non-refundable, pre-paid rates will be charged upon booking. The hotel reserves the rights to cancel reservations on declined credit cards.The person registering at check-in must be at least 18 years of age and must provide a valid photo ID and credit card. The ID and credit card must be in the same name as the guest's name on the booking confirmation.A record and/or copy of this ID and credit card may be retained to minimise the risk of fraudulent usage and for verification purposes.Reception hours are as follows:07:00 to 21:00 Monday to Friday08:00 to 17:00 on Saturday, Sunday and Public Holidays.If you expect to arrive outside reception opening hours, please inform Park Regis Anchorage in advance, using the contact details found on the booking confirmation.Please note that the studios and apartments are not serviced by housekeeping on a daily basis.Please note that there is a 0.8% charge when you pay with a Visa, Mastercard or BankCard credit card, a 3.3%% charge when you pay with a bank issued American Express credit card, and a 3.5% charge when you pay with an American Express or Diners Club credit card.Please note that furnishings and fixtures may vary between the different apartments. Views of the marina are not guaranteed.Please note that most 2 bedroom apartments have stairs, and no water views.
Hotel Guest Reviews of the Park Regis AnchorageOur hotel ratings and reviews are from real hotel guests. Priceline.com ensures that its reviews are guests-only by proactively sending hotel surveys to customers after they've completed their hotel stays. In the post-stay surveys, priceline.com hotel customers are asked a number of questions about their stay and the hotel. On a scale of 1-10 with 10 being the best, the survey asks guests to rate their overall experience and specifically rate the hotel's cleanliness, staff and location. Priceline.com does not allow site visitors to post unsolicited hotel reviews.
August 17, 2012
Family Traveling with Teens
Traveled with 2 x 17 year old girls for a national schools football tournament, room size small, not what I expected, but I'm not complaining as they did change the booking at last minute to accommodate the extra teenager. Staff was friendly and chatty and for the convenience of the location and the price it was ok. Car spaces were at a minimum.
(1 - 1 of 1 review)
- Adventurers Backpackers Resort from $36 (0.1mi)
- Allure Hotel And Apartments from $83 (0.1mi)
- Oaks M On Palmer from $98 (0.1mi)
- Quest Townsville Apartment from $110 (0.1mi)
- Rydges Southbank Hotel Townsville from $75 (0.1mi)


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[MLS 2013 COUNTDOWN] The Vancouver Whitecaps completed the signing of 28-year-old Englishman Nigel Reo-Coker, whose wife is American and who joined MLS instead of accepting offers from clubs in England and Russia. The move follows a settlement of the dispute of Reo-Coker's discovery claim between the 'Caps and Cascadia Cup rival Portland and gives the 'Caps potentially one of MLS's top defensive midfielders.
"He still believes and I believe that he hasn't hit his peak yet and time will tell if that's true or not," Vancouver coach Martin Rennie told reporters.
Vancouver had parted ways with Scottish DP Barry Robson and believes it has found his replacement with Reo-Coker, who spent 12 years in England with Aston Villa, West Ham United and Bolton Wanderers. Rennie says Reo-Coker is "a big piece for us."
REAL SALT LAKE.Real Salt Lake signed 20-year-old Colombian Olmes Garcia to a five-year contract after paying a transfer fee to his former club, Colombian First Division side Deportes Quindio. The rangy forward had seven goals in 47 appearances for Quindio.
"Garcia is a talented player who is a significant part of our long-term plan," Real Salt Lake General Manager Garth Lagerwey said in s statement. "He's fast, has good size and is skilled, but he'll need some time to get used to our system and to Utah. We'll be patient with him as we help him adjust to a new country, a new team, a new language, a new culture and new tactics."
Garcia made his RSL preseason debut in the 3-2 win over New England on Wednesday night, playing 25 minutes off the bench.
Friday, Feb. 22
Colorado vs. Los Angelesat Harder Stadium in Santa Barbara, Calif.
Seattle vs. Veracruzat the Kino Sports Complex in Tucson, Ariz.
UC Santa Barbara vs. Colorado "B"at Harder Stadium in Santa Barbara, Calif.
Saturday, Feb. 23
Chicago vs. Vancouver(Carolina Challenge Cup) at Blackbaud Stadium in Daniel Island, S.C.
Charleston Battery vs. Houston(Carolina Challenge Cup) at Blackbaud Stadium in Daniel Island, S.C.
San Jose vs. FC Dallas(Portland Preseason Tournament) at Jeld-Wen Field in Portland, Ore.
Portland vs. AIK Stockholm(Portland Preseason Tournament) at Jeld-Wen Field in Portland, Ore.
*3rd Place vs. 4th Place(Desert Diamond Cup) at the Kino Sports Complex in Tucson, Ariz.
1st Place vs. 2nd Place (Desert Diamond Cup) at the Kino Sports Complex in Tucson, Ariz. (TV: NBC Sports Network, live, 8 p.m. ET)
*Sporting KC vs. Toronto FC(Disney Pro Soccer Classic) 3rd Place at ESPN Wide World of Sports Complex in Kissimmee, Fla.
*Philadelphia vs. D.C. United(Disney Pro Soccer Classic) 2nd Place at ESPN Wide World of Sports Complex in Kissimmee, Fla.
*Columbus vs. Montreal(Disney Pro Soccer Classic) 1st Place at ESPN Wide World of Sports Complex in Kissimmee, Fla.
*Streamed on mlssoccer.com, wh

subset: commoncrawl


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Welcome to the second part of my NHL Realignment series!
From last time, recall that.
NHL Realignment is on the horizon for the 2012-12 season. The Winnipeg Jets are most certainly leaving the Southeast Division and the dominoes will start to fall from there.
The Nashville Predators, Detroit Red Wings and Columbus Blue Jackets are aiming to move to the Eastern Conference to take the place of the former Atlanta Thrashers. But it doesn't take a Geographer to realize that the Detroit Red Wings simply do not belong in the Southeast Division.
After reading the excellent NHL Realignment Project on Tomfulery, I was inspired to come up with some different possibilities.
Any alignment needs the following four points to be considered:
- Travel Time
- Schedule balance
- Games outside of a teams time zone
- Games against traditional rivals
I will be posting a series of posts detailing slightly Outside the Box possibilities for NHL Realignment. In some way, these all stretch the paradigm in some way.
Today, we will switch from the East-West Alignment of the past 18 years, and instead we are going to return to the old Campbell and Prince of Wales Conference that we had in place before. Each conference is then divided into East, West, and Central Divisions. A number of rivalries are kept intentionally, but not surprisingly, it is not perfect.


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Honduras resistance forms new political party
The National Front for Popular Resistance organized anti-government marches and demonstrations around Honduras.
Deposed President Zelaya returns to Honduras
"Our cry is for return of all rights and guarantees of Honduran democracy," Zelaya told supporters. "We are heading for a constituent assembly to win back power."
Honduran resistance takes off
Two sets of realities are opposed: a small, wealthy, U.S.-backed minority and popular mobilization, always in the background, but now gathering new strength.
Honduran teachers' protests trigger repression, fight-back
A strike by teachers in Honduras, which has led to a confrontation with the right-wing government, could have riipple effects.
World Notes: Tunisia, India and more
Greece: Communist Parties claim persecution; Iraq: Further confirmation of babies harmed in US war; Honduras: Killings of reporters continue; India: Communists prevail in municipal elections; Tunisia: Unexpected street heat.
Honduras ex-prez Zelaya voices anger re Wikileaks revelations
Former Honduran President Manuel Zelaya angrily blasted the U.S. State Department comments revealed in a secret diplomatic cable.
U.S. lawmakers call for halt to Honduras military aid
Thirty members of the United States House of Representatives have sent a letter to Secretary of State Hillary Rodham Clinton asking her to cut off U.S. aid to the armed forces and police in Honduras, until that country's government can demonstrate and end to human rights violations.
Honduran struggle grows, repression continues
The National Front for Popular Resistance (FNRP), in Honduras announced that 1.342.876 signatures had been collected calling for a constituent assembly.
Crisis in Honduras: labor takes hold
The labor movement, responding to murders of peasant activists and to precarious living conditions, is leading popular mobilization in Honduras.
World Notes: UN, Pakistan, Iran, Honduras, South Africa, Cuba
The International Labor Organization issued a report August 12 indicating that at the end of 2009 81 million people between 15 and 24 years of age were unemployed, up from 11.9 percent in 2007 to 13 percent last year.


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Kick Back And Relax Cookies
Additional Information
Step 1
In advance, using royal icing, make 9 tip 225 white drop flowers for each sandal; add tip 2 green dot centers and let dry. Set aside.
Step 2
Tint 3/4 of dough light rose. Roll out and cut sandals (flip over one sandal for each pair after cutting to make right and left sandal).
Step 3
Tint remaining dough dark rose and thin to piping consistency with water. Using thinned dough, pipe tip 3 stripes.
Step 4
Bake 10 minutes; cool. Attach flowers to sandals with royal icing.
Rose Icing Color
Leaf Green Icing Color
Meringue Powder
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Add rich tones and subtle character to cookies just by adding Wilton Icing Colors to dough before baking!
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Delightful details turn an Enchanted Castle Pan cake into a ?life?s a beach? birthday treat. Add a bright-hued plastic shovel and use Alphabet/Numerals Icing Decorations to personalize the sandy brown-sugar surface.
Set imaginations soaring with a simply constructed ?life?s a brown-sugar beach? cake. Build the castle with two stacked 6 in. Round Pan cakes and components from our Romantic Castle Cake Set.
For a cool summer treat, make some Ice Cream Sandwich Cookies. The cookies and the ice cream centers are cut using a shaped cookie cutter. Wrap completed sandwiches in plastic wrap and keep in freezer for snack-time!


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NX-100 Network Audio Adapter
The NX-100 Network Audio Adapter satisfies the requirements for transmitting high quality audio signals and control signal as serial data over networks using the IP protocol in real time. These include the internet and LANs and allow significant cost reductions when transmitting audio signals to various remote areas as costly dedicated lines do not have to be used.
- If there is no network delay, audio signals have only a minimal millisecond delay.
- Control data including contact and serial data can also be transmitted along with the audio signals.
- Two-way audio signal transmission is possible with a single NX-100 unit as every unit is equipped with an audio input and output.
- The multicast-capable NX-100 allows simultaneous transmission of audio signals to be made to multiple locations depending on transmission method:
- Unicast ÔÇö up to 4 locations,
- Multicast ÔÇö up to 64 locations.
- No audio signal degradation or loss, even when transmitting over crowded networks such as the internet.
- Greater data reliability using IP networks with the protocol's ability to prevent data problems during transmission.
- The NX-100's contact input can initiate and terminate audio transmissions without having to use dedicated control equipment such as a PC.
- Hardware use ensures operational reliability over only software-driven applications.
- Using IP to transmit audio signals over the internet allows low cost operation rather than dedicated lines.
- The NX-100 is equipped with a DC input to allow operation on AC as well as DC.
- Software-driven operational menus enhance ease of use.
NX-100 Firmware
NX-100 Software
NX-100 Brochure
NX-100 Cook Book
NX-100 White paper
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On Tap Today: Remembering Howlin' Wolf and Muddy Waters
Howlin' Wolf died in 1976, Muddy Waters in 1983, but there are musicians still around today who played with the blues legends, who are keeping their music alive today. Musicians like Jody Williams, a guitarist who played with Wolf, and Bob Margolin, Waters' guitarist for seven years, and Grammy winner James Cotton, who played with both Wolf and Waters.
Those three musicians, as well as the Fabulous Thunderbirds and multi-instrumentalist Tinsley Ellis, come together for a special Wolf and Waters tribute show, "Blues at the Crossroads II." The show begins at 8 p.m. Tuesday at Potawatomi Bingo Casino's Northern Lights Theater. Tickets are $35 to $45 and available to purchase at the box office, by calling (800) 745-3000 and clicking here. »Read Full Blog Post
4 places to 'drink while you think'
Want to know where to play trivia in Milwaukee? Here are four trivia hot spots in Milwaukee that you recommended for Monday through Thursday. On Tap this Weekend hosts, Heather Ronaldson and Brandon Tschacher, checked out what you love about them. Game on! »Read Full Blog Post
Dierks Bentley, Cheap Trick playing Milwaukee Admirals concerts
The Milwaukee Admirals are bringing in country singer Dierks Bentley and power pop act Cheap Trick for post-game concerts at the BMO Harris Bradley Center early next year.
This will actually be Bentley's second year in a row he's performed a concert after an Admirals game. Rockford, Ill. band Cheap Trick, a frequent presence in Milwaukee, was last here opening for Aerosmith at the Harley-Davidson 110th Anniversary Celebration. »Read Full Article
Carr Valley, La Quercia and New Glarus producers at Midwest dinner Nov. 8 at Bacchus
A dinner called Masters of the Midwest on Nov. 8 at Bacchus will bring together well-regarded cheese, dry-cured pork and beer producers from the region.
Sid Cook of Carr Valley Cheese Co. based in La Valle, Herb Eckhouse of La Quercia in Norwalk, Iowa, and Dan Carey of New Glarus Brewing Co., New Glarus, will attend the dinner, which will feature their products. »Read Full Blog Post
Exclusive Video: Interview with Scott Aukerman from 'Comedy Bang! Bang!'
Laverne and Shirley. They're not burly.
These are not merely keen observations. They're the inspired words taken from Scott Aukerman's freestyle rap about Milwaukee, which you can see for yourself below from our hilarious 10 for Tap video interview. »Read Full Article
On Tap for Today: Mums and a movie
Welcome to Monday. Don't say you weren't warned.
There are a couple of things going on that merit your attention. »Read Full Blog Post


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We're excited to announce that Fowlsheugh has been awarded a Certificate of Excellence on TripAdvisor!
We are really grateful to everyone who takes the time to give us feedback and really pleased to read all your nice comments. We can only take some of the credit as it's the seabird city spectacle and the full sight, sound and smell experience that is responsible for so many people loving the reserve.
It's an important place: more than 100,000 seabirds return each year to breed at Fowlsheugh and it is internationally important because of the major numbers of seabirds that breed there. In recognition of its importance the cliffs are designated a Special Protection Area under European law.
Seabirds have been struggling in Scotland in recent decades (you can more read about that here, here and here) but we're hoping for another good year with lots of healthy chicks.
If you visit Fowlsheugh or any of our other reserves this summer, we'd love to hear from you and to see your photos. You can find us on Facebook and Twitter.
Guillemot with fish at Fowlsheugh taken by visitor Andy Wilson.
Puffins at Fowlsheugh taken by visitor Robert Lenfert
Kittiwakes at Fowlsheugh taken by visitor Andy Wilson.
Razorbill at Fowlsheugh taken by visitor Robert Lenfert
Derren Fox and Kirsty Nutt describe the seabird breeding season success at both Fowlsheugh and Troup Head and why Scotland's seabirds are still struggling.
On a day like this, summer feels a long time ago... but it's nice to think back to those long, bright days when a walk along cliffs in Aberdeenshire was filled with the sounds of calling seabirds. From the kittiwakes repeatedly calling their own names to the strange laughing arrrs of guillemots.
Two of Aberdeenshire's seabird colonies are also RSPB Scotland nature reserves – this reserve Fowlsheugh and Troup Head near Pennan, which is also home to Scotland's only mainland gannet colony.
Each year we monitor how the seabirds that breed on the cliffs are doing by making accurate counts and observations in specific sections of the cliffs or 'plots'. The changes in these counts give us an index of how the birds are faring from one year to the next.
We had some good news from our plot counts this year. The number of nesting kittiwakes at Troup Head's plots was up from 395 last year to 414 and these pairs produced 460 young. Kittiwakes at Fowlsheugh had a great breeding year too with 394 pairs in the plots there producing 545 chicks - a record!
Longer-term trends
2015 saw all the reserve staff out counting seabirds Fowlsheugh and Troup Head. This is because every three years we count every single bird on these two huge colonies, and, as you can imagine, it's a challenging job! This year between us we counted over 100,000 birds and nests! After several weeks of counting, checking and recounting we have some final figures to share with you and the news is encouraging for some species.
The spectacular cliffs at Fowlsheugh (Derren Fox)
There appears to be some good news for both guillemots and razorbills this year, with numbers at Fowlsheugh up significantly on the last count back in 2012: guillemot numbers (recorded as individuals rather than nests) increased from 44,922 in 2012 to 55,507 in 2015. Over the same period, the number of razorbills (the second most numerous of the auk species here) went from 5,260 to 7,426.
Kittiwake numbers had a very slight increase too, with numbers of AONs (Apparently Occupied Nests) going from 9,439 to 9,655. This may not seem like much of an increase, but following on from a massive local and national decline and poor productivity (the number of chicks raised each year) this is still encouraging.
Kittiwake by Grahame Madge (rspb-images.com)
We've got even more comforting news about Fowlsheugh's kittiwakes. Our productivity studies this year – we follow a number of nests through the breeding period and seeing how many chicks each nest fledges – have shown they had a brilliant year!
From the nine study plots scattered through the colony, we found that on average productivity was 1.38 chicks per nest, which is the best we've had here since we started collecting data on productivity in 1993!
They aren't out of the woods yet, and numbers wise they've got a long way to go to get anywhere near the numbers in the early 1990s, but it's certainly nice to have some better news to spread about our kittiwakes.
Seabird numbers at Fowlsheugh (1992-2015)
Kittiwakes and gannets at Troup Head (Kirsty Nutt)
Up at Troup Head on the north coast, there has been a similar story with the auks, with guillemot numbers increasing from 14,030 in 2011 to 20,539 this year and razorbill numbers going from 1256 to 2147. Fulmar numbers are also up a little on the last count.
But, it's not all good news I'm afraid from Troup, with kittiwake numbers declining again, down to 7,180 AONs from 7,961 in 2011.
Seabird numbers at Troup Head (1969-2015)
The rest of Scotland
In 2015, other RSPB Scotland nature reserves recorded increases in seabird numbers and lots of healthy seabird chicks fledging their nests, despite the exceptionally wet summer we had. On Tiree, guillemot numbers increased from 2,068 in 2014 to 2,634 individuals this year, while at Fidra in the Firth of Forth, there were 1,026 active puffin burrows, up from around only 800 in 2009.
The figures are a welcome reprieve from the chronic declines seen across Scotland in recent years, but don't pop the champagne cork just yet.
These short-term increases are often coming after a period of phenomenally fast decline, like with Fowlsheugh's kittiwakes. And seabirds in Shetland and Orkney continue to struggle. Only 570 kittiwake pairs were recorded this year at Marwick Head on Orkney – a decline of 90 per cent since 1999, when the site held 5,573 pairs. Guillemot numbers at Marwick Head also dropped from 34,679 to 8,645 over the same period. Devastatingly, this year saw kittiwakes being lost entirely from North Hill in Orkney. The bottom line is that across Scotland, since 2000, we've lost two thirds of our kittiwakes, Arctic skuas and Arctic terns.
What's gone wrong?
We don't have all the answers – the marine environment is complex – but we are beginning to understand the subtle connections of the marine food chain and how they can be unravelled. Warming seas creates changes in the plankton (the bottom of the food chain) which results in fewer sandeels which are an important food for chicks. Fewer sandeels means fewer chicks survive and if this is repeated year after year, it plays a big role in the devastating declines we have witnessed.
What can we do?
Scotland has already designated more Marine Protected Areas than any other part of the British Isles, but the Scottish Government could help do more. They have already identified 14 potential Special Protection Areas, which are internationally important parts of our sea; unfortunately, they are dragging their feet when it comes to designating them.
You can find out more about the problems facing seabirds and how you can help safeguard sealife at rspb.org.uk/joinandhelp/donations/campaigns/sealife/
Eleven "dancing walkers" (or is that "walking dancers"?) joined Mark on a calm, warm and eventually sunny evening on the cliffs. Before we started I was told that they really, really wanted to see Puffins - so no pressure!!
We talked about the impact of the winter on the birds - the wreck of Puffins in the early Spring, and whether this would impact breeding numbers significantly. The entrance to the reserve still looks bleached, probably from salt spray in the winter, but further south the flowers are in full bloom.
We looked at Razorbills and Guillemots, the telescope allowing very close views so that everyone could appreciate the differences in colour of the birds.
At Henry's Scorth one then 2 Puffins flew in and perched so we could get close scope views. Although no jigs were danced, everyone was delighted! Moving on, photographing cliff top Razorbills, we stopped to admire Fulmars, with their strange "tube-noses", again the scope coming in handy.
At the shelter, I did a quick scan, then left the group to count the Puffins, while I collected a few eggs from the shelter. When I returned I was told there were 2, 5 or 6 Puffins - not bad from the 7 I had counted.
Kittewake, Guillemot and Razorbill eggs were demonstrated. There are always two reactions from the sight of the auk eggs - men tend to laugh while women have a sharp intake of breath at the size compared to the size of the bird!
After 2 hours we wandered back to the car park. Everyone had a great time and fantastic sightings at the sea bird city.
This is officially my last guided walk of the season, but please continue visiting and enjoying the cliffs during the summer.


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Do you have an interest in researching the genealogy records of your relatives in Winnebago County? Would you like to obtain copies of their birth, marriage and death certificates without having to leave your home?
Visit www.genealogy.winnebagocountyclerk.com for more information.
Please note, all certificates purchased online are $12 each.
Under Illinois State law, genealogy records are defined as:
• Birth certificates that are 75 years or older;
• Marriage certificates that are 50 years or older; and
• Death certificates that are 20 years or older


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Israeli pilot recalls smashing a rival's nuclear ambitionsBreaking News
The setting sun, at Raz's back, illuminated the reactor as if by spotlight. Raz flipped a switch with his index finger and released two 2,000-pound bombs. Seven other Israeli fighter jets flying with him did the same.
In one bold action on June 7, 1981, Israel's military had left the Osiraq nuclear reactor near Baghdad in smoldering ruins and dealt a blow to Saddam Hussein's nuclear ambitions.
"We didn't see a single Iraqi MiG (fighter), and not a single surface-to-air missile was fired," Raz says. "The whole operation was just too perfect."
The Osiraq mission is getting renewed attention in Israel now that the United Nations Security Council is likely to take up the issue of Iran's nuclear program, setting up a possible showdown between Iran and the West.
When asked in December how far he would go to prevent Iran from developing a nuclear weapon, the Israeli military chief of staff, Lt. Gen. Dan Halutz, said "2,000 kilometers" -- the approximate flying distance between Israel and key Iranian nuclear sites.
Halutz says diplomatic efforts won't thwart Iran's nuclear ambitions. "I believe that the political means that are used by the Europeans and the U.S. to convince the Iranians to stop the project will not succeed."
However, military observers say a quick, Osiraq-style Israeli strike against Iranian targets is unlikely. "We'll never see ... eight planes swooping down on Iran," Raz says. "It could never happen."
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CHANDLER, Ariz. -- Supermarket retailers are bullish on shrinking the DVD shrink rate, even if it means keeping the products behind the service counter. As the popularity of the DVD movie format soars to unprecedented levels, retailers are finding that customers don't always want to pay for their favorite hit movies. Many supermarkets take such a closely guarded approach that they do not display the sleek, portable products on the floor at all. "We get a real beating in [DVD] sell-through ...
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Hello All,
We have ladies walks taking place in four regions this year, and discussions to take place about mens walks in two of our regions. This requires a lot of planning and dedicated team members and importantly, pilgrims. Please check out the UK Walks page and see if you can help with either team or sponsoring a pilgrim.
Don't forget you can also use the prayer page to share your concerns or joys and each person asking for pray gets an email saying how many people are praying for them. So do go onto the prayer section and help other community members by praying for them as well as adding your own.
If you would like anything included on the website, please get in touch with me using the "Contact Us" section. If you would like to contact any of the National Board or Regional committee members too, then use the same method.
Yours in Christ


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Noah Letuligasenoa wished his two enormous cousins good luck before kickoff.
The linemen grinned, then vowed to squash him, but the Elk Grove High School senior tight end-linebacker countered with conviction, "You won't be able to catch me."
On a night in which hardly anyone broke free because the defenses refused to allow it, a throwback game of hard hits and defensive stands broke out. The No. 2 Thundering Herd prevailed 7-3 Friday over No. 7 Grant in Elk Grove in a Delta Valley Conference showdown.
In the long, storied history of one of the Sac-Joaquin Section's most spirited rivalries, never has it resulted in this sort of score with this much at stake with the sort of collisions that you'd half think included the crunching of metal and shattering of glass, like so many car wrecks.
Letuligasenoa will see his cousins – the left side of Grant's massive offensive front of Shawn Matautia and Darrin Paulo – in a more civil church setting on Sunday. They might even hand each other an ice pack, and they'll certainly help each other up after prayer.
"We can scheme as much as we want on offense, but what this one came down to was defense and heart," said Letuligasenoa, a three-year starter and a team captain. "I'll need an ice pack for my head, my back, my legs. We have a ton of respect for Grant, and some of those guys are my family."
Grant (4-3) led 3-0 on a Ruben Garza 27-yard field goal. Tommy Arnold, a unique two-way player for Elk Grove (7-0), recovered a fumble at the Grant 41 and scored a moment later on a 13-yard quarterback keeper in the third quarter. He also plays on the defensive line and linebacker.
All told, the Herd rejoiced in its finest effort of the season. Elk Grove's opponents coming in had managed just seven total wins as traditional powers Lincoln of Stockton, Del Campo and Nevada Union are having off years.
There was no doubt about this effort against this foe. Grant's other losses were by six points total to ranked Oak Ridge and Del Oro.
"You don't know what you have until you get into a game like this against a team like this, and we found out," Elk Grove coach Chris Nixon said.
Nixon was the Herd offensive coordinator during Elk Grove's dominant 1997 and '98 Sac-Joaquin Section Division I championship repeat run, seasons that included playoff victories over Grant.
The lowest-scoring Grant-Elk Grove game before this was in 1991 in Del Paso Heights. Grant beat top-ranked Elk Grove 13-6 for Mike Alberghini's first win. He remains the Grant coach with a résumé that includes six section titles.
Grant running back Deandre Whittington-Grays was held to 55 yards.
Wadus Parker of Elk Grove managed 88 yards, but 60 came on one carry.
It was a night for Elk Grove's stoppers, led by defensive linemen B'won Canada, Sai Ta'amu and Dior Vela and linebackers Elijah Jones, Manny Scott-Anderson and Spencer Sheff, and defensive back Shaunard Harts.
"I live for these games," Letuligasenoa said, rubbing out welts on his arms. "Offense is fun, but this was a hands-in-the-dirt kind of game."
Letuligasenoa said this game, which could decide the DVC title, might launch his program. Elk Grove won 12 games in both 2011 and 2012. It seeks more this time.
"I have a really special feeling about this team," he said.
Joe Davidson and Mike Finnerty break down Week 7 of high school football and look ahead from 9 to 10 a.m. on ESPN1320 (linked later to ESPN1320.net).


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Professor Sandiford (Character)
from Art School Confidential (2006)
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- Art School Confidential (2006) Played by John Malkovich
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Professor Sandiford: Now I don't have any particular wisdom to impart to you people, except to say this, these four words - don't have unrealistic expectations. If you want to make money, better drop out right now, go to banking school, or website school - anywhere but art school. And remember, only 1 out of 100 of you will ever make a living as an artist. See more »
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Tokyo Halloween Night
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◇ child is a headgear for the preschool and elementary school children.
■ is the head, neck and shoulders to protect evacuation shelter.
■ softens the shock when it hits something highly クッツション flame resistant wadding in head.
■ ears often hear voices and sounds with ears Department.
■ is the shelter of the excellent heat-resistant and fire-resistant aluminum flame retardant material.
■ nameplate can fill out name, contact number and blood type (of neck) in.
■ adjustable one-touch the neck strap is covered by rubber bands, can be adjusted immediately.
■ reflective tape (neck muscle Division) in night is safe.
■ conveniently in the Pocket and carrying a whistle, etc..
■ floor cushions and even prevent also use shelter, etc. in cold.
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■ material: aluminum flame retardant material, flame-resistant cotton, polyester, uchinuno: cotton
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This product cannot be shipped to United States from the store.
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The linen was good
There are no stars at all. No pool, no room conditioning! In summer time the temperature inside the room achieves 30-35C. You have to fill out the form what exactly you will eat on breakfast on the next day. The rooms are very small and dirty. You even can not open a window because the handle is mounted near the ceiling. After 2 days of staying we changed the hotel for Heliopark Kaiserhoff- perfect solution!
Location! Wonderful district, very beautiful buildings. And breakfast - great!
The staff is very friendly and helpful. the hotel (reception, and probably the entire hotel) is open 24/7, and you can ask for a sauna in the middle of the night for an extra charge, if you wish. besides, there's a WiFi available at any time without asking the staff for a access-code
The room was pretty clean and nice, however smoked through.
The staff was very pleasant and helpful.The atmosphere in the hotel was very nice and relaxing. Airco in the room works perfect. Hotel's garden is outstanding. The are offering breakfast a-la-cart which is not common in the mid-range hotels. Fast free wi-fi internet access.
No restaurant in the hotel, but one good nearby (200m).
Room design, service and garden were the best features
Maybe a bit expensive, but worth it
The room was really nice. The hotel is situated in the very center of the city with splendid view. Cinema, restaurants and shops are just 2-3 minutes away.
Some problems with electronic keys. No hair-drier in the room. We found 2 needles on the floor.
Great staff, mostly English and German speaking lovely Russian ladies, very good breakfast, great sushi restaurant and coffee bar on site, very central location, walking distance to everything, mall with cinema and grocery store across the street, comfortable beds with nice linen, nice shower with small tub, English and German TV channels, business area with computer/internet, currency exchange with good rates, 24 hour front desk, security in front lobby, felt very safe, I would stay hear again the next time that I visit Kaliningrad
Restaurant open until 2 a.m. could be noisy if your room is above them, but great front desk moved me to higher floor after a few nights of trying to deal with the noise, which was not horrible, but very noticeable at times.
Fresh inside, good kitchen, best price
wery good
The rooms were absolutely fantastic. Their design, from top to bottom, were modern, clean, and attractive. The comfort of being in my room substantially contributed to my trip.
There was a bit of a walk to downtown, although the nearby ponds made the walk quite nice.
Location is in a perfect, quit place. Very freindly staff. Very good breakfast.
The bed is too small for two. We had to share bathroom and toilet with one more room.
Quiet, english speaking and helpfull staff, free parking in the couryard, good internet.
We needed two separate beds, but room had only one wide bad for two of us :(
Eeverything was very very good.
There was just one minus - breakfasts began late&cafe for breakfast was placed outside of the hotel in next to it building so to get there you should go out from the hotel and ebter another building what is not so nice during cold or rainy weather.
Surprisingly good kitchen, good connection to the airport using new motorway.
Internet not working, no wi-fi, staff barelly knowing English
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Gypsy moths doing a number on NJ trees
Posted: 8:00 PM EDT Jul 29, 2013 Updated: 7:12 PM EDT Jul 30, 2013
An invasive species is doing a number on New Jersey trees.
State agriculture officials say gypsy moths have moderately or severely damaged nearly 2,900 acres of trees statewide.
Last year, the leaf-eaters only chewed through about a thousand acres' worth of trees.
That's the lowest mark since New Jersey started tracking this activity in 1970.
Still, officials say gypsy moth populations are cyclical.
They'll conduct a survey this fall to determine whether spraying is necessary.
Copyright 2013 WFMZ. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Most Cited Molecular and Biochemical Parasitology Articles
The most cited articles published since 2011, extracted from Scopus.
The Apicomplexan AP2 family: Integral factors regulating Plasmodium developmentHeather J. Painter | Tracey L. Campbell | Manuel Llinás
Volume 176, Issue 1, March 2011, Pages 1-7
Malaria is caused by protozoan parasites of the genus Plasmodium and involves infection of multiple hosts and cell types during the course of an infection. To complete its complex life cycle the parasite requires strict control of gene regulation for survival and successful propagation. Thus far, the Apicomplexan AP2 (ApiAP2) family of DNA-binding proteins is the sole family of proteins to have surfaced as candidate transcription factors in all apicomplexan species. Work from several laboratories is beginning to shed light on how the ApiAP2 proteins from Plasmodium spp. contribute to the regulation of gene expression at various stages of parasite development. Here we highlight recent progress toward understanding the role of Plasmodium ApiAP2 proteins in DNA related regulatory processes including transcriptional regulation and gene silencing. © 2010 Elsevier B.V. All rights reserved.
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6Nicola Baker | Sam Alsford | David Horn
Volume 176, Issue 1, March 2011, Pages 55-57
To be effective, therapeutic compounds must typically enter target cells and, in some cases, must be concentrated or modified. Thus, uptake and activation mechanisms often form the basis of selectivity against infectious agents. Loss-of-function screens can be used to identify proteins involved in drug uptake and metabolism and may also identify clinically relevant potential resistance mechanisms. We used a genome-scale RNA interference (RNAi) library to identify loss-of-function resistance mechanisms in bloodstream-form Trypanosoma brucei. Nifurtimox-Eflornithine Combination Therapy (NECT) was recently introduced for Human African Trypanosomiasis and we focus on these drugs here. Screens for resistance to nifurtimox and a related drug, benznidazole, identified loss of nitroreductase (NTR) pro-drug activator function. A screen for resistance to the amino-acid analogue, eflornithine, identified loss of amino-acid transporter (AAT6) function. Our results confirm recent findings and suggest that NTR or AAT6 loss-of-function represent major potential mechanisms of resistance to these drugs. Thus, bloodstream-form T. brucei RNAi libraries present a versatile tool for selective genetic screening and for the rapid identification of drug-activation, uptake and potential resistance mechanisms. © 2010 Elsevier B.V. All rights reserved.
Developmental regulation of gene expression in the absence of transcriptional control: The case of kinetoplastidsSusanne Kramer
Volume 181, Issue 2, February 2012, Pages 61-72
Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi and Leishmania, are the only known organisms that do not regulate the transcription of protein coding genes transcribed by RNA polymerase II. Yet, profound changes in gene expression are induced by many different external stimuli and stresses, the extreme example are cascades of changes in gene expression initiated by differentiation triggers that ultimately and irreversibly result in the massive morphological and metabolic changes observed during life-cycle progression. This review explores how kinetoplastids change gene expression by looking at life-cycle stage specific changes in chromatin, mRNA processing, mRNA stability, mRNA translation, protein stability and protein modifications. © 2011 Elsevier B.V. All rights reserved.
Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transportersGabriela Schumann Burkard | Pascal Jutzi | Isabel Roditi
Volume 175, Issue 1, January 2011, Pages 91-94
An inducible RNA interference (RNAi) library, consisting of a pool of independent stable transformants with 9-fold genome coverage, was constructed in bloodstream form Trypanosoma brucei using an improved transfection protocol. RNAi induction and selection of resistant parasites was performed in the presence of melarsoprol or eflornithine. The former led to the isolation of the adenosine transporter TbAT1, which is known to be involved in melarsoprol uptake, while the latter identified an amino acid transporter, AAT6. Knockdown of AAT6 reduced mRNA levels to 30-35% in independent clones and increased resistance to eflornithine >5-fold. Genome-wide screens with this library allow an unbiased approach to gene discovery, are extremely rapid and do not exclude essential genes. © 2010 Elsevier B.V.
Autophagy in parasitic protists: Unique features and drug targetsAna Brennand | Melisa Gualdrón-López | Isabelle Coppens | Daniel J. Rigden | Michael L. Ginger | Paul A M Michels
Volume 177, Issue 2, June 2011, Pages 83-99
Eukaryotic cells can degrade their own components, cytosolic proteins and organelles, using dedicated hydrolases contained within the acidic interior of their lysosomes. This degradative process, called autophagy, is used under starvation conditions to recycle redundant or less important macromolecules, facilitates metabolic re-modeling in response to environmental cues, and is also often important during cell differentiation. In this review, we discuss the role played by autophagy during the life cycles of the major parasitic protists. To provide context, we also provide an overview of the different forms of autophagy and the successive steps in the autophagic processes, including the proteins involved, as revealed in recent decades by studies using the model organism Saccharomyces cerevisiae, methylotrophic yeasts and mammalian cells. We describe for trypanosomatid parasites how autophagy plays a role in the differentiation from one life cycle stage to the next one and, in the case of the intracellular parasites, for virulence. For malarial parasites, although only a limited repertoire of canonical autophagy-related proteins can be detected, autophagy seems to play a role in the removal of redundant organelles important for cell invasion, when sporozoites develop into intracellular trophozoites inside the hepatocytes. The complete absence of a canonical autophagy pathway from the microaerophile Giardia lamblia is also discussed. Finally, the essential role of autophagy for differentiation and pathogenicity of some pathogenic protists suggests that the proteins involved in this process may represent new targets for drug development. Opportunities and strategies for drug design targeting autophagy proteins are discussed. © 2011 Elsevier B.V. All rights reserved.
A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlueTakeshi Q. Tanaka | Kim C. Williamson
Volume 177, Issue 2, June 2011, Pages 160-163
Efforts to move from malaria control to eradication will require new approaches to block malaria transmission, such as the development of anti-malarial drugs with gametocytocidal activity. Here fluorescent oxidoreduction indicator alamarBlue is used to develop a screen for gametocyte viability. The fluorescent signal increases linearly with gametocyte number (R2 = 0.99) and determination of the IC50 of epoxomicin demonstrated the assay was reproducible and sensitive (IC50 2.16 ± 0.57 nM, Z′-factor 0.81 ± 0.01). Six anti-malarials were also tested and at 10 μM only primaquine and dihydroartemisinin (DHA) had gametocytocidal activity. This new assay provides an important tool to efficiently screen compounds for gametocytocidal activity. © Published by Elsevier B.V.
Analysis of the transcriptome of the root lesion nematode Pratylenchus coffeae generated by 454 sequencing technologyAnnelies Haegeman | Soumi Joseph | Godelieve Gheysen
Volume 178, Issues 1-2, July 2011, Pages 7-14
To study interactions between plants and plant-parasitic nematodes, several omics studies have nowadays become extremely useful. Since most data available so far is derived from sedentary nematodes, we decided to improve the knowledge on migratory nematodes by studying the transcriptome of the nematode Pratylenchus coffeae through generating expressed sequence tags (ESTs) on a 454 sequencing platform. In this manuscript we present the generation, assembly and annotation of over 325,000 reads from P. coffeae. After assembling these reads, 56,325 contigs and singletons with an average length of 353 bp were selected for further analyses. Homology searches revealed that 25% of these sequences had significant matches to the Swiss-prot/trEMBL database and 29% had significant matches in nematode ESTs. Over 10,000 sequences were successfully annotated, corresponding to over 6000 unique Gene Ontology identifiers and 5000 KEGG orthologues. Different approaches led to the identification of different sequences putatively involved in the parasitism process. Several plant cell wall modifying enzymes were identified, including an arabinogalactan galactosidase, so far identified in cyst nematodes only. Additionally, some new putative cell wall modifying enzymes are present belonging to GHF5 and GHF16, although further functional studies are needed to determine the true role of these proteins. Furthermore, a homologue to a chorismate mutase was found, suggesting that this parasitism gene has a wider occurrence in plant-parasitic nematodes than previously assumed. Finally, the dataset was searched for orthologues against the Meloidogyne genomes and genes involved in the RNAi pathway. In conclusion, the generated transcriptome data of P. coffeae will be very useful in the future for several projects: (1) evolutionary studies of specific gene families, such as the plant cell wall modifying enzymes, (2) the identification and functional analysis of candidate effector genes, (3) the development of new control strategies, e.g. by finding new targets for RNAi and (4) the annotation of the upcoming genome sequence. © 2011 Elsevier B.V. All rights reserved.
Candidate anthelmintic resistance-associated gene expression and sequence polymorphisms in a triple-resistant field isolate of Haemonchus contortusSally M. Williamson | Bob Storey | Sue Howell | Kate M. Harper | Ray M. Kaplan | Adrian J. Wolstenholme
Volume 180, Issue 2, December 2011, Pages 99-105
An isolate of Haemonchus contortus, UGA/2004, highly resistant to benzimidazoles, levamisole, and ivermectin was isolated from sheep at the University of Georgia, and passaged through experimentally infected goats. We measured the expression of twenty-nine mRNAs encoding drug targets and P-glycoproteins (P-gps), comparing the results to a fully susceptible laboratory passaged isolate. Expression levels of some nicotinic acetylcholine receptor mRNAs were markedly different in UGA/2004. Levels of the Hco-acr-8b mRNA, encoding a truncated subunit, were very high in resistant L3, but undetectable in susceptible larvae, with expression of the full-length Hco-acr-8a mRNA also significant increased. Expression of Hco-unc-63 and Hco-unc-29.3 mRNAs was significantly reduced in the resistant larvae. Expression of the Hco-glc-3 and Hco-glc-5 mRNAs, encoding glutamate-gated chloride channel subunits, were slightly reduced in resistant larvae. We observed significant increases in the expression of the Hco-pgp-2 and Hco-pgp-9 mRNAs in the UGA/2004 larvae, consistent with previous reports; we also saw a decrease in the levels of Hco-pgp-1 mRNA. Treatment of the larvae with ivermectin and moxidectin in vitro produced variable and inconsistent changes in P-gp mRNA levels. The sequences of the β-tubulin isotype 1 mRNAs showed that the resistant larvae had a resistance-associated allele frequency of >95% at codon 200 and ∼40% and codon 167. No changes at codon 198 were present. The presence of the truncated acr-8b mRNA may be a reliable indicator of levamisole resistance, but complex changes in gene expression associated with macrocyclic lactone resistance make the identification of a single genetic marker for this resistance difficult. © 2011 2011 Elsevier B.V. All rights reserved.
Identification of inhibitors for putative malaria drug targets among novel antimalarial compoundsGregory J. Crowther | Alberto J. Napuli | James H. Gilligan | Kerstin Gagaring | Rachel Borboa | Carolyn Francek | Zhong Chen | Eleanor F. Dagostino | Justin B. Stockmyer | Yu Wang | Philip P. Rodenbough | Lisa J. Castaneda | David J. Leibly | Janhavi Bhandari | Michael H. Gelb | Achim Brinker | Ingo H. Engels | Jennifer Taylor | Arnab K. Chatterjee | Pascal Fantauzzi | Richard J. Glynne | Wesley C. Van Voorhis | Kelli L. Kuhen
Volume 175, Issue 1, January 2011, Pages 21-29
The efficacy of most marketed antimalarial drugs has been compromised by evolution of parasite resistance, underscoring an urgent need to find new drugs with new mechanisms of action. We have taken a high-throughput approach toward identifying novel antimalarial chemical inhibitors of prioritized drug targets for Plasmodium falciparum, excluding targets which are inhibited by currently used drugs. A screen of commercially available libraries identified 5655 low molecular weight compounds that inhibit growth of P. falciparum cultures with EC50 values below 1.25μM. These compounds were then tested in 384- or 1536-well biochemical assays for activity against nine Plasmodium enzymes: adenylosuccinate synthetase (AdSS), choline kinase (CK), deoxyuridine triphosphate nucleotidohydrolase (dUTPase), glutamate dehydrogenase (GDH), guanylate kinase (GK), N-myristoyltransferase (NMT), orotidine 5'-monophosphate decarboxylase (OMPDC), farnesyl pyrophosphate synthase (FPPS) and S-adenosylhomocysteine hydrolase (SAHH). These enzymes were selected using TDRtargets.org, and are believed to have excellent potential as drug targets based on criteria such as their likely essentiality, druggability, and amenability to high-throughput biochemical screening. Six of these targets were inhibited by one or more of the antimalarial scaffolds and may have potential use in drug development, further target validation studies and exploration of P. falciparum biochemistry and biology. © 2010 Elsevier B.V.
A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytesChristopher L. Peatey | Timothy P. Spicer | Peter S. Hodder | Katharine R. Trenholme | Donald L. Gardiner
Volume 180, Issue 2, December 2011, Pages 127-131
Recent success in the global reduction campaign against malaria has resulted in the possibility that it may be feasible to drastically reduce or even eradicate malaria even without the introduction of a vaccine. However, while there has been significant effort to design the next generation of antimalarial drugs, one area that is underrepresented in the current antimalarial pharmacopeia is that of transmission blocking drugs directed at late-stage gametocytes. Here we describe the development of a robust and simple assay that is amenable to a high throughput format for the discovery of new antigametocyte drugs. © 2011 2011 Elsevier B.V. All rights reserved.
Clonorchis sinensis enolase: Identification and biochemical characterization of a glycolytic enzyme from excretory/secretory productsXiaoyun Wang | Wenjun Chen | Fengyu Hu | Chuanhuan Deng | Chenhui Zhou | Xiaoli Lv | Yongxiu Fan | Jingtao Men | Yan Huang | Jiufeng Sun | Dong Hu | Jingfang Chen | Yabo Yang | Chi Liang | Huanqin Zheng | Xuchu Hu | Jin Xu | Zhongdao Wu | Xinbing Yu
Volume 177, Issue 2, June 2011, Pages 135-142
Enolase plays a key role in energy metabolism and development of most organisms. We isolated a gene encoding enolase from Clonorchis sinensis (C. sinensis) adult cDNA library and expressed the recombinant protein in Escherichia coli. C. sinensis enolase (Csenolase) was identified as both an excretory/secretory product and a tegumental component of C. sinensis by western blot analysis. The transcriptional level of Csenolase was examined at adult worm, metacercaria, cercaria and egg of C. sinensis, and results showed that Csenolase is transcribed at the four life stages of C. sinensis while showing a significant higher expression level at the stage of adult worm. Immunohistochemical localization indicated that Csenolase was specifically deposited on the tegument of adult worm and cyst wall of metacercaria. Ligand blot assay revealed a specific characteristic of dose-dependent plasminogen-binding activity of Csenolase and kinetic parameters were explored using 2-phospho-d-glycerate (2-PGA) as the primary substrate by monitoring the conversion of nicotinamide-adenine dinucleotide (NADH) into nicotinamide adenine dinucleotide (NAD). In addition, Csenolase exhibited active enzyme activity in catalytic reactions while the anti-Csenolase serum inhibited the enzyme activity. In vitro incubation experiments revealed that Csenolase might play key roles in the growth of the parasites. In conclusion, Csenolase is an important glycolytic enzyme required for the development of C. sinensis, and may be a potential vaccine candidate and drug target against C. sinensis infection. © 2011 Published by Elsevier B.V. All rights reserved.
Schistosomiasis control: Praziquantel forever?Donato Cioli | Livia Pica-Mattoccia | Annalisa Basso | Alessandra Guidi
Volume 195, Issue 1, January 2014, Pages 23-29
Since no vaccine exists against schistosomiasis and the molluscs acting as intermediate hosts are not easy to attack, chemotherapy is the main approach for schistosomiasis control. Praziquantel is currently the only available antischistosomal drug and it is distributed mainly through mass administration programs to millions of people every year. A number of positive features make praziquantel an excellent drug, especially with regard to safety, efficacy, cost and ease of distribution. A major flaw is its lack of efficacy against the immature stages of the parasite. In view of its massive and repeated use on large numbers of individuals, the development of drug resistance is a much feared possibility. The mechanism of action of praziquantel is still unclear, a fact that does not favor the development of derivatives or alternatives. A large number of compounds have been tested as potential antischistosomal agents. Some of them are promising, but none so far represents a suitable substitute or adjunct to praziquantel. The research of new antischistosomal compounds is an imperative and urgent matter. © 2014 Elsevier B.V. All rights reserved.
Antigenic variation in African trypanosomesDavid Horn
Volume 195, Issue 2, January 2014, Pages 123-129
Studies on Variant Surface Glycoproteins (VSGs) and antigenic variation in the African trypanosome, Trypanosoma brucei, have yielded a remarkable range of novel and important insights. The features first identified in T. brucei extend from unique to conserved-among-trypanosomatids to conserved-among-eukaryotes. Consequently, much of what we now know about trypanosomatid biology and much of the technology available has its origin in studies related to VSGs. T. brucei is now probably the most advanced early branched eukaryote in terms of experimental tractability and can be approached as a pathogen, as a model for studies on fundamental processes, as a model for studies on eukaryotic evolution or often all of the above. In terms of antigenic variation itself, substantial progress has been made in understanding the expression and switching of the VSG coat, while outstanding questions continue to stimulate innovative new approaches. There are large numbers of VSG genes in the genome but only one is expressed at a time, always immediately adjacent to a telomere. DNA repair processes allow a new VSG to be copied into the single transcribed locus. A coordinated transcriptional switch can also allow a new VSG gene to be activated without any detectable change in the DNA sequence, thereby maintaining singular expression, also known as allelic exclusion. I review the story behind VSGs; the genes, their expression and switching, their central role in T. brucei virulence, the discoveries that emerged along the way and the persistent questions relating to allelic exclusion in particular. © 2014 The Authors.
Central carbon metabolism of Plasmodium parasitesKellen L. Olszewski | Manuel Llinás
Volume 175, Issue 2, February 2011, Pages 95-103
The central role of metabolic perturbation to the pathology of malaria, the promise of antimetabolites as antimalarial drugs and a basic scientific interest in understanding this fascinating example of highly divergent microbial metabolism has spurred a major and concerted research effort towards elucidating the metabolic network of the Plasmodium parasites. Central carbon metabolism, broadly comprising the flow of carbon from nutrients into biomass, has been a particular focus due to clear and early indications that it plays an essential role in this network. Decades of painstaking efforts have significantly clarified our understanding of these pathways of carbon flux, and this foundational knowledge, coupled with the advent of advanced analytical technologies, have set the stage for the development of a holistic, network-level model of plasmodial carbon metabolism. In this review we summarize the current state of knowledge regarding central carbon metabolism and suggest future avenues of research. We focus primarily on the blood stages of Plasmodium falciparum, the most lethal of the human malaria parasites, but also integrate results from simian, avian and rodent models of malaria that were a major focus of early investigations into plasmodial metabolism. © 2010 Elsevier B.V. All rights reserved.
Differential expression of proteins in antimony-susceptible and -resistant isolates of Leishmania donovaniNeha Biyani | Alok Kumar Singh | Swati Mandal | Bhavna Chawla | Rentala Madhubala
Volume 179, Issue 2, October 2011, Pages 91-99
Visceral Leishmaniasis (VL) is a parasitic disease caused by the protozoan parasite Leishmania donovani. Resistance to pentavalent antimonials (SbV), the mainstay therapy for leishmaniasis is now a major concern, due to emergence of drug resistance. Hence, understanding the underlying mechanism of resistance to antimonials is required. Here we used quantitative mass spectrometery to identify global proteome differences between antimony-susceptible/-resistant isolates. We detected modification of expression of proteins involved in the key metabolic pathways. Comparative proteomic analysis indicated increase in glycolysis in the antimony-resistant isolates. Elevated expression of stress related proteins implicated in oxidative stress was observed in the resistant parasites. Most importantly, we observed upregulation of proteins that may have a role in intracellular survival of the parasite in the resistant isolates. The identified parasite proteins could serve as surrogate markers for resistance or susceptibility and would also help in understanding the underlying mechanism of resistance to antimonials. © 2011 Elsevier B.V. All rights reserved.
Metabolomic analysis of trypanosomatid protozoaDarren J. Creek | Jana Anderson | Malcolm J. McConville | Michael P. Barrett
Volume 181, Issue 2, February 2012, Pages 73-84
Metabolomics aims to measure all low molecular weight chemicals within a given system in a manner analogous to transcriptomics, proteomics and genomics. In this review we highlight metabolomics approaches that are currently being applied to the kinetoplastid parasites, Trypanosoma brucei and Leishmania spp. The use of untargeted metabolomics approaches, made possible through advances in mass spectrometry and informatics, and stable isotope labelling has increased our understanding of the metabolism in these organisms beyond the views established using classical biochemical approaches. Set within the context of metabolic networks, predicted using genome-wide reconstructions of metabolism, new hypotheses on how to target aspects of metabolism to design new drugs against these protozoa are emerging. © 2011 Elsevier B.V. All rights reserved.
The VSG C-terminal domain is inaccessible to antibodies on live trypanosomesAngela Schwede | Nicola Jones | Markus Engstler | Mark Carrington
Volume 175, Issue 2, February 2011, Pages 201-204
In the mammalian host, the Trypanosoma brucei cell surface is covered with a densely packed protein coat of a single protein, the variant surface glycoprotein (VSG). The VSG is believed to shield invariant surface proteins from host antibodies but there is limited information on how far antibodies can penetrate into the VSG monolayer. Here, the VSG surface coat was probed to determine whether it acts as a barrier to binding of antibodies to the membrane proximal VSG C-terminal domain. The binding of C-terminal domain antibodies to VSG221 or VSG118 was compared with antibodies recognising the cognate whole VSGs. The C-terminal VSG domain was inaccessible to antibodies on live cells but not on fixed cells. This provides further evidence that the VSG coat acts as a barrier and protects the cell from antibodies that would otherwise bind to some of the other externally disposed proteins. © 2010 Elsevier B.V. All rights reserved.
Metabolomics and malaria biologyViswanathan Lakshmanan | Kyu Y. Rhee | Johanna P. Daily
Volume 175, Issue 2, February 2011, Pages 104-111
Metabolomics has ushered in a novel and multi-disciplinary realm in biological research. It has provided researchers with a platform to combine powerful biochemical, statistical, computational, and bioinformatics techniques to delve into the mysteries of biology and disease. The application of metabolomics to study malaria parasites represents a major advance in our approach towards gaining a more comprehensive perspective on parasite biology and disease etiology. This review attempts to highlight some of the important aspects of the field of metabolomics, and its ongoing and potential future applications to malaria research. © 2010 Elsevier B.V. All rights reserved.
Genome-wide identification and characterization of a panel of house-keeping genes in Schistosoma japonicumShuai Liu | Pengfei Cai | Nan Hou | Xianyu Piao | Heng Wang | Tao Hung | Qijun Chen
Volume 182, Issues 1-2, March 2012, Pages 75-82
Quantitative real-time polymerase chain reaction (qPCR), as one of the most sensitive and precise gene expression analysis methods, is frequently used to validate data obtained in high-through-put assays. qPCR requires reference genes with stable transcription for accurate normalization. However, no systematic studies on such genes have been performed in the genus Schistosoma japonicum. In this study, eight novel candidate genes selected from a microarray analysis and four commonly used reference genes were systematically validated in a series of qPCR experiments. Based on the results of geNorm, Normfinder, BestKeeper, and the comparative delta-cycle threshold (ΔCT) integrated analysis, the genes PSMD4, NDUFV2, and TPC2L were found to be most stably expressed in all S. japonicum developmental stages; meanwhile, ACTB and TUBA were found as the least stably expressed genes. This study provided, at the first time, data for genes that can be explored as reliable references in transcriptomic analysis of S. japonicum. © 2012 Elsevier B.V.
Evolution of parasitism in kinetoplastid flagellatesJulius Lukeš | Tomáš Skalický | Jiří Týč | Jan Votýpka | Vyacheslav Yurchenko
Volume 195, Issue 2, January 2014, Pages 115-122
Kinetoplastid protists offer a unique opportunity for studying the evolution of parasitism. While all their close relatives are either photo- or phagotrophic, a number of kinetoplastid species are facultative or obligatory parasites, supporting a hypothesis that parasitism has emerged within this group of flagellates. In this review we discuss origin and evolution of parasitism in bodonids and trypanosomatids and specific adaptations allowing these protozoa to co-exist with their hosts. We also explore the limits of biodiversity of monoxenous (one host) trypanosomatids and some features distinguishing them from their dixenous (two hosts) relatives. © 2014 Elsevier B.V.
The four trypanosomatid eIF4E homologues fall into two separate groups, with distinct features in primary sequence and biological propertiesEden R. Freire | Rafael Dhalia | Danielle M N Moura | Tamara D. Da Costa Lima | Rodrigo P. Lima | Christian R S Reis | Katie Hughes | Regina C B Q Figueiredo | Nancy Standart | Mark Carrington | Osvaldo P. De Melo Neto
Volume 176, Issue 1, March 2011, Pages 25-36
Translation initiation in eukaryotes requires eIF4E, the cap binding protein, which mediates its function through an interaction with the scaffolding protein eIF4G, as part of the eIF4F complex. In trypanosomatids, four eIF4E homologues have been described but the specific function of each is not well characterized. Here, we report a study of these proteins in Trypanosoma brucei (TbEIF4E1 through 4). At the sequence level, they can be assigned to two groups: TbEIF4E1 and 2, similar in size to metazoan eIF4E1; and TbEIF4E3 and 4, with long N-terminal extensions. All are constitutively expressed, but whilst TbEIF4E1 and 2 localize to both the nucleus and cytoplasm, TbEIF4E3 and 4 are strictly cytoplasmic and are also more abundant. After knockdown through RNAi, TbEIF4E3 was the only homologue confirmed to be essential for viability of the insect procyclic form. In contrast, TbEIF4E1, 3 and 4 were all essential for the mammalian bloodstream form. Simultaneous RNAi knockdown of TbEIF4E1 and 2 caused cessation of growth and death in procyclics, but with a delayed impact on translation, whilst knockdown of TbEIF4E3 alone or a combined TbEIF4E1 and 4 knockdown led to substantial translation inhibition which preceded cellular death by several days, at least. Only TbEIF4E3 and 4 were found to interact with T. brucei eIF4G homologues; TbEIF4E3 bound both TbEIF4G3 and 4 whilst TbEIF4E4 bound only to TbEIF4G3. These results are consistent with TbEIF4E3 and 4 having distinct but relevant roles in initiation of protein synthesis. © 2010 Elsevier B.V. All rights reserved.
Insights into blood feeding by schistosomes from a proteomic analysis of worm vomitusStephanie L. Hall | Simon Braschi | Martha Truscott | William Mathieson | Italo M. Cesari | R. Alan Wilson
Volume 179, Issue 1, September 2011, Pages 18-29
Whilst the schistosome tegument has been intensively studied there is little information about processes in the gut, the other major interface with the bloodstream, apart from the well characterised cascade of proteases involved in haemoglobin digestion. To gain insights into gut function we undertook a proteomic analysis of worm vomitus and performed in vitro erythrocyte feeding experiments. Additional to known gut constituents we identified two proline carboxypeptidases as well as enzymes capable of hydrolysing carbohydrate and ester linkages. Schistosome serpin and a2 macroglobulin protease inhibitors were also present. A series of "carrier proteins", principally lipid-binding saposins and cholesterol-binding NPC-2 were also detected, together with ferritins and calumenin that bind ferric iron and calcium, respectively. The presence of these lysosomal proteins and other lysosomal markers in the vomitus, plus observations on the cytology of the gut epithelium suggest that lysosomes directly secrete their contents into the gut lumen to digest incoming plasma constituents as well as haemoglobin. It is also likely that the carrier proteins function to sequester essential organic and inorganic nutrients for uptake into the epithelium. The feeding experiments indicate that erythrocytes are uncoated as they pass through the oesophagus, intersecting with its secretions, whilst the endocytosis of space-filling dextran into the gut epithelium provides a potential mechanism for carrier uptake by macropinocytosis. © 2011 Elsevier B.V.
Discovery of factors linked to antimony resistance in Leishmania panamensis through differential proteome analysisJohn Walker | Rafael Gongora | Juan José Vasquez | Jolyne Drummelsmith | Richard Burchmore | Gaetan Roy | Marc Ouellette | Maria Adelaida Gomez | Nancy G. Saravia
Volume 183, Issue 2, June 2012, Pages 166-176
The rate of treatment failure to antileishmanial chemotherapy in Latin America is up to 64%. Parasite drug resistance contributes to an unknown proportion of treatment failures. Identification of clinically relevant molecular mechanisms responsible for parasite drug resistance is critical to the conservation of available drugs and to the discovery of novel targets to reverse the resistant phenotype. We conducted comparative proteomic-based analysis of Leishmania (Viannia) panamensis lines selected in vitro for resistance to trivalent antimony (Sb III) to identify factors associated with antimony resistance. Using 2-dimensional gel electrophoresis, two distinct sub-proteomes (soluble in NP-40/urea and Triton X-114, respectively) of promastigotes of WT and Sb III-resistant lines were generated. Overall, 9 differentially expressed putative Sb-resistance factors were detected and identified by mass spectrometry. These constituted two major groups: (a) proteins involved in general stress responses and (b) proteins with highly specific metabolic and transport functions, potentially directly contributing to the Sb-resistance mechanism. Notably, the sulfur amino acid-metabolizing enzymes S-adenosylmethionine synthetase (SAMS) and S-adenosylhomocysteine hydrolase (SAHH) were over-expressed in Sb III-resistant lines and Sb III-resistant clinical isolates. These enzymes play a central role in the upstream synthesis of precursors of trypanothione, a key molecule involved in Sb-resistance in Leishmania parasites, and suggest involvement of epigenetic regulation in response to drug exposure. These data re-enforce the importance of thiol metabolism in Leishmania Sb resistance, reveal previously unrecognized steps in the mechanism(s) of Sb tolerance, and suggest a cross-talk between drug resistance, metabolism and virulence. © 2012 Elsevier B.V. All rights reserved.
Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfectionSuresh M. Ganesan | Joanne M. Morrisey | Hangjun Ke | Heather J. Painter | Kamal Laroiya | Margaret A. Phillips | Pradipsinh K. Rathod | Michael W. Mather | Akhil B. Vaidya
Volume 177, Issue 1, May 2011, Pages 29-34
Genetic manipulation of Plasmodium falciparum in culture through transfection has provided numerous insights into the molecular and cell biology of this parasite. The procedure is rather cumbersome, and is limited by the number of drug-resistant markers that can be used for selecting transfected parasites. Here we report a new selectable marker that could allow multiple transfections. We have taken advantage of our finding that a critical function of the mitochondrial electron transport chain (mtETC) in the erythrocytic stages of P. falciparum is the regeneration of ubiquinone as co-substrate of dihydroorotate dehydrogenase (DHODH), and that transgenic P. falciparum expressing ubiquinone-independent DHODH from yeast (yDHODH) are resistant to all mtETC inhibitors. We assessed the possibility of using yDHODH as a positive selectable marker for transfections of P. falciparum, including its use in gene disruption strategies. We constructed a transfection vector designed for gene disruption, termed pUF-1, containing the yDHODH gene as the positive selection marker in combination with a previously described fused yeast cytosine deaminase-uracil phosphoribosyl transferase gene as a negative selection marker. Transfection of the D10 strain followed by selection with atovaquone yielded positively selected parasites containing the plasmid, demonstrating that yDHODH can be used as a selective marker. Atovaquone, however, could not be used for such selection with the Dd2 strain of P. falciparum. On the other hand, we demonstrated that yDHODH transgenic parasites could be selected in both strains by Plasmodium DHODH-specific triazolopyrimidine-based inhibitors. Thus, selection with DHODH inhibitors was superior in that it successfully selected transgenic Dd2 parasites, as well as yielded transgenic parasites after a shorter period of selection. As a proof of concept, we have successfully disrupted the type II vacuolar proton-pumping pyrophosphatase gene (PfVP2) in P. falciparum by double crossover recombination, showing that this gene is not essential for the survival of blood stage parasites. © 2011 Elsevier B.V. All rights reserved.
The molecular epidemiology of parasite infections: Tools and applicationsA. J. Lymbery | R. C A Thompson
Volume 181, Issue 2, February 2012, Pages 102-116
Molecular epidemiology, broadly defined, is the application of molecular genetic techniques to the dynamics of disease in a population. In this review, we briefly describe molecular and analytical tools available for molecular epidemiological studies and then provide an overview of how they can be applied to better understand parasitic disease. A range of new molecular tools have been developed in recent years, allowing for the direct examination of parasites from clinical or environmental samples, and providing access to relatively cheap, rapid, high throughput molecular assays. At the same time, new analytical approaches, in particular those derived from coalescent theory, have been developed to provide more robust estimates of evolutionary processes and demographic parameters from multilocus, genotypic data. To date, the primary application of molecular epidemiology has been to provide specific and sensitive identification of parasites and to resolve taxonomic issues, particularly at the species level and below. Population genetic studies have also been used to determine the extent of genetic diversity among populations of parasites and the degree to which this diversity is associated with different host cycles or epidemiologically important phenotypes. Many of these studies have also shed new light on transmission cycles of parasites, particularly the extent to which zoonotic transmission occurs, and on the prevalence and importance of mixed infections with different parasite species or intraspecific variants (polyparasitism). A major challenge, and one which is now being addressed by an increasing number of studies, is to find and utilize genetic markers for complex traits of epidemiological significance, such as drug resistance, zoonotic potential and virulence. © 2011 Elsevier B.V. All rights reserved.


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Engineering programs are in place in Amarillo to provide more workers and continue educating already employed engineers if Bell Helicopter should need more such staff.
Bell officials announced Thursday the relocation of some projects from Fort Worth to their Amarillo plant. Amarillo College provides several training classes for Bell employees.
Ed Nolte, chair of the manufacturing department, said they previously discussed with Bell officials varying needs for an upcoming new program.
"We were looking at going to more training in sheet metal areas," he said. "We do have that training and we do have that capability. We'll adapt what they need with the new program. We're going to bring in some of those things, train whatever employees they have or anyone that needs to be hired on."
Nolte said other programs like aerospace manufacturing and aviation maintenance have connections to Bell. Any increase in hiring at Bell could be accommodated with training at AC.
West Texas A&M University's new engineering program has 51 students this semester, said Dr. Freddie Davis. The program's intent is to prepare engineers for businesses like Bell.
"We're trying to provide for customers of engineers in the Panhandle and they're certainly one candidate," he said.
WT officials talked with Bell officials during the planning of the engineering program, which is in its first year. Davis said they didn't cover long-term needs or indicate any jumps in their production that would require more engineers.
Texas Tech's engineering graduate program in Amarillo could be one of the draws for Bell. Dr. Wallace Johnston, business manager for the Amarillo program, said the ability to continue engineering education would be a plus for any business expanding or building in the area.
"The availability of graduate engineering education would be appropriate to communicate to people who might be employed here at Bell," he said.
Johnston said he visited with Bell officials when the program was beginning and their primary employment needs were for skilled craftsmen. Expanding assembly may mean more need for engineers, but he has not talked with Bell officials.
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Burying Supply-Side Once and for All
If you are going to base all your efforts to win political power on a single economic theory, as conservatism has over the last 30 years, you might want to make sure it works. But that's what's so surprising about supply-side economics: Despite the fact that its central claim has been belied by decades of economic experience, it persists.
Read more here.
This article was originally published in Democracy: A Journal of Ideas.
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The Gunslinger (The Dark Tower, 1) (original 1982; edition 1982)
by Stephen King
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Overall, I thought The Gunslinger was fantastic. It had some slow moments that left me scratching my head,wondering wtf was going on. But for the most part. I was intrigued enough by the world, Roland, and the Man in Black to keep reading. In my head seeing Clint "Blondie" Eastwood and hearing Johnny Cash, the ultimate man in black. I can't wait to read the next book.
A good setup for what follows but slower and less focused in places than I am used to seeing from King. Nevertheless, an intriguing start to an epic fantasy story.
Have a grand plan to get through this Stephen King opus before the film comes out. So begin at the beginning. He always makes me uneasy as I read and this was no different. I did do a double take at the rabbits coming to "silflay" - Uh - isn't that a made up word from "Watership Down"? Google it and yes, it is - part of King's references to other books.
A wonderful blend of science fiction, post apocalypse with a strong dash of the supernatural, wrapped up in a western package. It's easy to see the influence that this work has had on so much that has come after it. Although confusing at times, I very much enjoyed the story and the characters. Looking forward to the next installment of the series.
I originally read the pre-revised book and was unimpressed, but I was also expecting something of more scope, adventure and clarity.
6 years later (and possibly with the benefit of a change in taste), I've now read the revised edition and it is much more interesting. My true rating might be 3.5/5 where before it was 2/5. Roland's character, history and quest are explored more satisfactorily, and the world he inhabits is much more vivid.
It still suffers from being basically a prolonged introduction to a much larger and much more bizarre story, and as such can't really stand on its own except as a curiosity.
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Amazon.com Amazon.com Review (ISBN 0452284694, Paperback)Thirty-three years, a horrific and life-altering accident, and thousands of desperately rabid fans in the making, Stephen King's quest to complete his magnum opus rivals the quest of Roland and his band of gunslingers who inhabit the Dark Tower series. Loyal DT fans and new readers alike will appreciate this revised edition of The Gunslinger, which breathes new life into Roland of Gilead, and offers readers a "clearer start and slightly easier entry into Roland's world."
King writes both a new introduction and foreword to this revised edition, and the ever-patient, ever-loyal "constant reader" is rewarded with secrets to the series's inception. That a "magic" ream of green paper and a Robert Browning poem, came together to reveal to King his "ka" is no real surprise (this is King after all), but who would have thought that the squinty-eyed trio of Clint Eastwood, Lee Van Cleef, and Eli Wallach would set the author on his true path to the Tower? While King credits Tolkien for inspiring the "quest and magic" that pervades the series, it was Sergio Leone's The Good, the Bad, and the Ugly that helped create the epic proportions and "almost absurdly majestic western backdrop" of Roland's world.
To King, The Gunslinger demanded revision because once the series was complete it became obvious that "the beginning was out of sync with the ending." While the revision adds only 35 pages, Dark Tower purists will notice the changes to Allie's fate and Roland's interaction with Cort, Jake, and the Man in Black--all stellar scenes that will reignite the hunger for the rest of the series. Newcomers will appreciate the details and insight into Roland's life. The revised Roland of Gilead (nee Deschain) is embodied with more humanity--he loves, he pities, he regrets. What DT fans might miss is the same ambiguity and mystery of the original that gave the original its pulpy underground feel (back when King himself awaited word from Roland's world). --Daphne Durham
(retrieved from Amazon Thu, 12 Mar 2015 18:06:42 -0400)
First portion of an epic story of a fantastic world of good versus evil in which the hero, The Gunslinger, pursues The Man in Black.
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The discussion Tuesday was about traffic counts and travel times, but what Charleston City Council actually voted for was to keep bicyclists safe.
It was the right thing to do.
Council, by a vote of 8-5, gave Charleston County the go-ahead to convert a traffic lane into a bike and pedestrian lane on the bridge from West Ashley to the peninsula. At present bicyclists have to approach and exit the bridge on a dirt shoulder and cross on a narrow, raised sidewalk. It's hair-raising and dangerous - so dangerous that most opt not to do it.
Opponents sounded alarms about possible traffic jams as a result of going from four lanes to three, but a study commissioned by the county indicates the plan will work.
The transformation, after all, is far more than simply designating one lane for bicycles and pedestrians.
It involves a safe approach to the bridge and exit from it. It will adjust the way cars feed onto the bridge from Folly Road and Hwys. 61 and 17. And it will add a new lane of traffic at the problem intersection of Bee Street and Lockwood Boulevard on a route that hospital employees often use. (Also, surveys indicate that hospital workers are among those likely to commute by bike, further easing vehicular traffic.)
Providing a safe way for bicyclists to cross the Ashley is key to the city becoming more bike-friendly, a trend found in major cities around the globe.
It's a trend the business community says is key to attracting smart, young people who want to work in a community that cares for the environment and its residents' health.
And crossing the Ashley is a vital link in a bike system that will go from the terminus of the West Ashley Greenway to East Cooper, and eventually the Isle of Palms.
Still, five council members were unswayed by those arguments, by a petition with 1,666 signatures supporting the bike lane, by accounts about three area bicyclists who died tragically after being struck by vehicles and by 33 people speaking on behalf of the bike lane. (Aside from members of council, only one person spoke against it.)
Those naysayers' stance is especially disappointing, given that projections indicate it will take cars at most 13 additional seconds to cross the bridge after the bike lane is completed.
Also, the traffic numbers that opponents latched onto need scrutiny. They talk about how more than 56,000 people cross the Ashley (both directions) daily and how that number is expected to increase to 59,000 by 2035.
By then, 21 years from now, one would hope that City Council and other local and state leaders will have convinced the S.C. Department of Transportation to replace the aging bridge, which is already considered functionally obsolete.
The replacement, of course, will certainly include safe, wide bike/pedestrian access.
Until that happens, however, City Council has acted wisely to take cyclists and pedestrians out of harm's way as they cross the Ashley River.


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Fourth Early Modern Symposium: Art and Its Afterlives
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CFP for a conference to take place on Saturday 17 November 2012 at The Courtauld Institute of Art.
Art and Its Afterlives aims to address the ways in which the work of art continues to resonate after its creation. While much art history takes as its focus the initial facture of the work of art, this one-day symposium explores what happens to early modern art after the moment of its making. How did early modern works continue to be created in their display, preservation, and reception from the moment of their creation on? Papers will examine how art is shaped by its afterlives – whether these collect, curate, cut up, cut out, copy or correct it – and the ways in which art both persists and changes through time as a material object, a field of generative meaning, and a subject of debate and interpretation. Material, technical and social histories as well as theoretical approaches drawn from the discipline of art history and other fields of the humanities are welcome. Accounts from curatorial practice and the field of museology are also encouraged.
The question of afterlife is an pertinent topic for art history in general, where the work of art is uniquely tied to a particular assemblage of materials which inevitably change with time, rendering fraught questions of preservation, the presence or possibility of copies, the idea of original state, and how a work of art is staged for a viewer. Less material but no less concrete, the interactions between the work and the viewer, and between the work and the its assumed referent are not stable but open to change. The question of afterlife is particularly relevant for the early modern period, when emergent art markets and cultures of collection allowed not only the circulation of artworks, but also their appropriation and adaptation. Taking as its point of departure Bourdieu's encouragement to investigate 'not only the material production of the work but also the production of the value of the work', this symposium privileges the afterlives of art and the alternative histories they present.
Topics for discussion may include, but are not limited to:
• Histories of collection and display – acquisition and the accrual of value; assignment of category or genre; travel and re-contextualization; political appropriation and/or subversion
• Conservation and technical art history – preservation vs. restoration of past state; hidden layers and the discovery of the underneath; changing material support
• Reception and criticism –boundary between art and reception; development of art historical practice; shifting contexts of viewership and viewer negotiation
• Copy and imitation – changing perceptions of a master's hand vs. workshop; forging and faking; serial reproduction; changing conceptions of emulation and originality; contemporary uses of early modern works and spaces
• Destruction and embellishment – iconoclasm and the religious image; revolution and vandalism; disassembly and remaking; framing and re-framing
Art and Its Afterlives is the fourth symposium of The Courtauld's Early Modern Department. We invite proposals from scholars and postgraduates for papers that explore the theme of art and its afterlives in all forms of visual and material culture from the early modern period (c.1560-1848) including painting, sculpture, architecture, decorative arts, performance, print media, graphic arts, and the intersections between them.
Please send proposals of no more than 250 words by 1 July 2012 to email@example.com and email@example.com.
Organized by Laura Sanders and Francesca Whitlum-Cooper (The Courtauld Institute of Art)
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The Courtauld Institute of Art
Somerset House, Strand, London WC2R 0RN
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