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Macyo January to be tried as adult for killing pregnant woman
Macyo January was four months shy of turning eighteen when he allegedly murdered a pregnant woman and her husband during a burglary earlier this year. But a judge has ruled that he'll be treated as if he'd already celebrated his birthday.
January will be tried as an adult for the crime, which is thought to have concluded an escalating series of crimes, including the beating of an elderly woman. Could the killings have been prevented had the police responded to an alarm? Details below.
A Facebook page "celebrating the life, love and laughter of Whitney Butler and David Dunlap" includes the following photo....
...and some very poignant memories, like this one:
My dearest Whitney Butler -- I struggle to find the words. I feel bad I hadn't seen or talked to you recently, but I was so happy to talk to you when I found out you were going to be married. I wish in retrospect I had found the time and money to come to your wedding, or to visit you more often. VA Beach is only a mere 4 hours away, but life always got in the way. You were one of my closest friends at Hollins and I always think of you when I remember our days there. I know if you were still alive today that we'd pick up right where we left off and laugh like we always did. Regardless of anything, I hope you know how much I loved you and valued our friendship. I miss you friend.
A fundraising campaign in David's memory, with proceeds going to the American Belgian Malinois Club Charitable Trust -- he was a Fort Carson soldier who loved this breed of dog -- notes that the couple married on September 22, 2012, meaning they were relative newlyweds when their lives were abruptly taken.
Another photo of Whitney Butler and David Dunlap.
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What happened? On the morning of January 14, according to the Colorado Springs Gazette, Dunlap and Butler were informed by their security company about a burglar alarm that had been triggered at their home. They headed there separately -- and both were killed as they walked in the door.
Evidence presented at the hearing about whether January should be tried as an adult suggests that Dunlap was gunned down first, from behind. Butler arrived shortly thereafter. She appears to have been kneeling over Dunlap's body when she was shot in the head.
The scene of the crime.
Regarding that alarm: A previous Gazette piece points out that the Colorado Springs Police Department was alerted to it 45 minutes before a neighbor heard gunfire at the home, but officers didn't respond. Why not? The answer suggested at a February hearing is that the department receives approximately 5,000 such reports about alarms per annum, with a hefty percentage of them turning out to be false alarms.
Which this one most certainly was not.
January was arrested for the crime in short order -- and it wasn't his first time in cuffs. A reported victim of abuse and neglect during his formative years, he's been in and out of trouble since at least the age of fourteen, and he's suspected of having been behind perhaps as many as twenty burglaries prior to the slaying of Butler and Dunlap. Moreover, at least a couple of the break-ins were marked by violence, with a 71-year-old woman having been robbed and beaten twice over the span of a few short months. A fifteen-year-old girl home sick from school was also roughed up in a separate incident.
Oh yeah: In a Department of Youth Corrections questionnaire filled out by January and cited at this week's hearing, he allegedly wrote that he wouldn't have a problem committing murder if he "could get away with it."
That's a long shot now. January can't face the death penalty owing to his age, but should he be found guilty of killing Butler and Dunlap, he could be sentenced to life without the possibility of parole. Here's a larger look at his booking photo.
Macyo January.
More from our Mile High Murder archive: "Lonnie White, seventeen, to be charged as adult in Reysean Abram on-bike murder (14)."
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Comment Re:Missing Info (Score 1) 639
the beeping is telling you that you're doing it wrong.
box on the front passenger seat means that the front passenger seat's airbag is activated. if you get into an accident, that's an extra airbag you'll need to replace.
the point is --- the seatbelt warning is not the only issue you're having

subset: commoncrawl


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Category:Andrea Neumann
From Wikimedia Commons, the free media repository
- Suzuki, Yoshiyuki. Andrea Neumann Profile. Improvised Music from Japan. "Born 1968 in Freiburg, grew up in Hamburg. Piano lessons since 1974. Studied piano at "Hochschule der Kunste" in Berlin. Since 1996 primarily active as improviser and composer in the areas of experimental and new music. ... "
This category has only the following subcategory.
- ► Inside piano (instrument) (2 F)
Media in category "Andrea Neumann"
The following 3 files are in this category, out of 3 total.


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Massage Therapy, Healing, Nutrition & Ayurveda
Drawing from this beautiful ancient system and wisdom, we combine authentic Ayurveda with a western approach, offering treatments,detoxification, nutritional advice and holistic counselling to help support your lifestyle, everyday health and emotional well being.
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Working on the principle of 'relaxation, restoration and rejuvenation', she holistically treats health problems, stress and related issues that can result in various symptoms and degrees of illness, or simply tension within the body or mind. In Ayurveda this closely relates to the three doshas and how they uniquely manifest as an 'imbalance', and are treated accordingly.
Ayurveda believes the route to health and happiness is to live according to your unique nature and to follow your heart; overcoming obstacles supported with simple therapies, deep relaxation,Sometimes a simple change to a small aspect in our lives, often looking at the cause whilst treating the symptom, can make a big transformation to how we think and feel.
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Every client is treated as unique ,and Lorettas Modern Ayurvedic Programmes -your own MAP to health is made to suit our individual health concerns or needs. This ranges from a bespoke wellness plan that starts with a 60-minute Ayurvedic health consultation, combining nutritional and lifestyle advice, detoxification to a specialised bespoke massage /healing teatment devised for you and your needs that day .
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The signature treatment is based on an intuitive therapeutic deep tissue massage combined with Ayurvedic techniques, Marma Therapy and healing to facilitate not only muscular release, but also to rebalance you at a deep physical and emotional level..The philosophy of Ayurveda and its treatments is to put you in touch with a deeper understanding within your own body, by removing stress to allow self-healing to take place.
This, alongside a de-stress rejuvenation treatment has helped people move forward in life by treating many of the physical or psychological problems we suffer from such as:
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Tagged with: Digital EditionRead More »
January 1, 2016
December 29, 2015
December 25, 2015
Top Apartment permits issued by Mecklenburg County in 2015
In construction news, 2015 will likely be remembered as the year of the apartment in Charlotte. Mecklenburg County issued 321 construction permits for projects that included five or more family apartments during the year. The top five of them, ranked ...
Tagged with: ApartmentsRead More »
Top residential permits from Mecklenburg County for 2015
Although apartments were the name of the game for many residents in 2015, there were still some traditional – and in some cases ostentatious – single-family homes being built around Mecklenburg County. The top 50 single-family residential construction permits for ...Read More »
Top commercial permits in 2015
With just over $3.5 billion in building permits awarded as of December 17, 2015 has seen no shortage of new construction in the Queen City. The total value of the permits issued in 2014 was just $2.74 billion, meaning this ...Read More »


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Paris 🏆🏆
Madrid 🏆
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Lisbon 🏆
Next stop: Milan!
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LG releases infographic that shows the "LG G4 by the numbers"
LG has today released an infographic they says will tell you all about its new flagship - "LG G4 by the numbers"
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Buy OPPO Smartphones at OppoStyle! Free express delivery worldwide.
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BBC News
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Automaton Updated with Host of New Features
Not too long ago, we took a look at an app by XDA Senior Member Akshay (Aky) that simulates smart cover functionality. Conceived originally
Beautiful Android Themes, Wallpapers, and Homescreens
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إطلاق سراح عضو بالأسرة الكويتية الحاكمة ناشط على تويتر
في سابقة هي الأولى من نوعها انتقد أحد أفراد أسرة الصباح الحاكمة في الكويت السلطات الكويتية مما أدى إلى اعتقاله وإطلاق سراحه بعد عدة أيام.
Hammacher Schlemmer - Homepage - The Unexpected Gifts - Hammacher Schlemmer
Shop for Unique Gifts, Gadgets, Electronics, and More at Hammacher Schlemmer. Buy unique gifts and gift ideas.
Ubergizmo is a popular news website that features honest, opinionated news &reviews of consumer electronics products and trends


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Day #1: Christopher's Lemonade Stand raised $130.
Seeking Alpha was the second place referrer. Thanks to everyone who participated in this effort. 29 days left to go…
Disclosure: The author has no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.
Additional disclosure: The total would have been $155 but for a grandfather who preferred to back this project offline.
Instablogs are blogs which are instantly set up and networked within the Seeking Alpha community. Instablog posts are not selected, edited or screened by Seeking Alpha editors, in contrast to contributors' articles.


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It only takes a minute to get started. Fill out our simple sign up form and login to the site.
This step is up to you but will drastically increase your chances of getting interest from other Christian members on the site. Write a little about yourself, your hobbies and upload your nicest photo of yourself.
Use our website's state-of-the-art search to find members who match your needs. Or just browse through listings of Christian singles and find singles that seem interesting.
Identified someone who looks suitable? Send them a few words or just a wink and see if anything happens. With a little luck you'll be on your way to a lifetime of happiness.
And start dating


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24 Grooviest Adaptations of '60s TV
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RT on DVD: Get Smart, Futurama: Bender's Game and the Obama DVD Controversy
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The Provost's Office is responsible for academic resources and budget, professional faculty matters, and the University's curriculum of instruction. The Provost's Office oversees the eight academic colleges, graduate school, library, institutional programs, institutional research and analysis, accreditation and assessment, and the Upper Great Plains Transportation Institute.
What's New in Academic Affairs
- Welcome new and returning faculty, staff, and students to the 2016-2017 school year!
- Congratulations to faculty who have received awards, earned tenure, or were promoted in 2015-2016! View the program from the Celebration of Faculty Excellence.
- Check out the Professional Development Workshops and Trainings that are currently being offered.
- Faculty Research Development proposals are due September 1, 2016.
Beth Ingram, Provost


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Top Definition
Quite literally means rubbish. In particular rubbish that comes out of a volcano - but can be any time of rubbish that is currently hot and steaming!
Look mate that's a load of tephra or I've had a tephra day
ayon kay guilder ika-20 ng Disyembre, 2004
Trending Now
Can you define these popular missing words?


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Meet Ove. He's a curmudgeon - the kind of man who points at people he dislikes as if they were burglars caught outside his bedroom window. He has staunch principles, strict routines, and a short fuse. People call him "the bitter neighbor from hell". But behind the cranky exterior there is a story and a sadness.
"Maybe my favorite book ever!"
A natural storyteller and raconteur in his own right - just listen to Paddle Your Own Canoe and Gumption - actor, comedian, carpenter, and all-around manly man Nick Offerman (Parks and Recreation) brings his distinctive baritone and a fine-tuned comic versatility to Twain's writing. In a knockout performance, he doesn't so much as read Twain's words as he does rejoice in them, delighting in the hijinks of Tom - whom he lovingly refers to as a "great scam artist" and "true American hero".
"Adventures of a timeless classic"
When four classmates from a small Massachusetts college move to New York to make their way, they're broke, adrift, and buoyed only by their friendship and ambition. There is kind, handsome Willem, an aspiring actor; JB, a quick-witted, sometimes cruel Brooklyn-born painter seeking entry to the art world; Malcolm, a frustrated architect at a prominent firm; and withdrawn, brilliant, enigmatic Jude, who serves as their center of gravity.
"Brutal, But Beautiful"
One Sunday afternoon in Southern California, Bert Cousins shows up at Franny Keating's christening party uninvited. Before evening falls, he has kissed Franny's mother, Beverly - thus setting in motion the dissolution of their marriages and the joining of two families.
The Newest Oprah Book Club 2016 Selection. Cora is a slave on a cotton plantation in Georgia. Life is hell for all the slaves but especially bad for Cora; an outcast even among her fellow Africans, she is coming into womanhood - where even greater pain awaits. When Caesar, a recent arrival from Virginia, tells her about the Underground Railroad, they decide to take a terrifying risk and escape. Matters do not go as planned - Cora kills a young white boy who tries to capture her. Though they manage to find a station and head north, they are being hunted.
"Great info, weak story"
As teenagers, Ifemelu and Obinze fall in love in a Nigeria under military dictatorship. The self-assured Ifemelu departs for America, where Obinze hopes to join her, but post-9/11 America will not let him in, and he plunges into a dangerous, undocumented life in London. Fifteen years later, after so long apart and so many changes, will they find the courage to meet again, face to face?
"Dazzling, Romantic, and Witty"
In the summer of 1976, recently widowed and childless, Ora Lee Beckworth hires a homeless old black man to mow her lawn. The neighborhood children call him the Pee-can Man; their mothers call them inside whenever he appears. When the police chief's son is found stabbed to death near his camp, the man Ora knows as Eddie is arrested and charged with murder. Twenty-five years later, Ora sets out to tell the truth about the Pecan Man.
"A bittersweet story,"
Having inspired a classic film and Broadway play, The Caine Mutiny is Herman Wouk's boldly dramatic, brilliantly entertaining novel of life—and mutiny—on a Navy warship in the Pacific theater. It was immediately embraced upon its original publication as one of the first serious works of American fiction to grapple with the moral complexities and the human consequences of the Second World War. In the intervening half century, this gripping story has become a perennial favorite, selling millions throughout the world, and claiming the Pulitzer Prize for fiction.
"Even Better than the Movie"
Ruth Jefferson is a labor and delivery nurse at a Connecticut hospital with more than 20 years' experience. During her shift, Ruth begins a routine checkup on a newborn, only to be told a few minutes later that she's been reassigned to another patient. The parents are white supremacists and don't want Ruth, who is African American, to touch their child. The hospital complies with their request, but the next day the baby goes into cardiac distress while Ruth is alone in the nursery. Does she obey orders, or does she intervene?
Making a living reproducing famous artworks for a popular online retailer and desperate to improve her situation, Claire is lured into a Faustian bargain with Aiden Markel, a powerful gallery owner. She agrees to forge a painting - a Degas masterpiece stolen from the Gardner Museum - in exchange for a one-woman show in his renowned gallery. But when that very same long-missing Degas painting is delivered to Claire's studio, she begins to suspect that it may itself be a forgery. Her desperate search for the truth leads Claire into a labyrinth of deceit where secrets hidden since the late 19th century may be the only evidence that can now save her life.
"Engrossing forage into art forgery and intrigue"
From the outside, Sycamore Glen, North Carolina, might look like the perfect all-American neighborhood. But behind the white picket fences lies a web of secrets that reach from house to house. Up and down the streets, neighbors quietly bear the weight of their own pasts - until an accident at the community pool upsets the delicate equilibrium. And when tragic circumstances compel a woman to return to Sycamore Glen after years of self-imposed banishment, the tangle of the neighbors' intertwined lives begins to unravel.
"Not bad"
Unfolding over four tumultuous weeks in present-day Washington, DC, Here I Am is the story of a fracturing family in a moment of crisis. As Jacob and Julia Bloch and their three sons are forced to confront the distances between the lives they think they want and the lives they are living, a catastrophic earthquake sets in motion a quickly escalating conflict in the Middle East. At stake is the meaning of home - and the fundamental question of how much aliveness one can bear.
"Wonderful novel marred by imperfect narration"
A debut novel already praised as "unbearably poignant and beautifully told" (Eimear McBride), this captivating story follows - over the course of four seasons - a misfit man who adopts a misfit dog. It is springtime, and two outcasts - a man ignored, even shunned by his village, and the one-eyed dog he takes into his quiet, tightly shuttered life - find each other, by accident or fate, and forge an unlikely connection. As their friendship grows, their small seaside town suddenly takes note of them.
"Simply Beautiful"
Venetia Lanyon, beautiful, intelligent and independent, lives in comfortable seclusion in rural Yorkshire with her precocious brother Aubrey. Her future seems safe and predictable: Either marriage to the respectable but dull Edward Yardley, or a life of peaceful spinsterhood. But when she meets the dashing, dangerous rake Lord Damerel, her well-ordered life is turned upside down, and she embarks upon a relationship with him that scandalizes and horrifies the whole community.
"Heaven for Heyer Fans"
Offred is a Handmaid in the Republic of Gilead, serving in the household of the enigmatic Commander and his bitter wife. She may go out once a day to markets whose signs are now pictures because women are not allowed to read. She must pray that the Commander makes her pregnant, for in a time of declining birthrates her value lies in her fertility, and failure means exile to the dangerously polluted Colonies. Offred can remember a time when she lived with her husband and daughter and had a job, before she lost even her own name....
"My Top Pick for 2012"
Pulitzer Prize, Fiction, 2016. It is April 1975, and Saigon is in chaos. At his villa, a general of the South Vietnamese army is drinking whiskey and, with the help of his trusted captain, drawing up a list of those who will be given passage aboard the last flights out of the country. The general and his compatriots start a new life in Los Angeles, unaware that one among their number, the captain, is secretly observing and reporting on the group to a higher-up in the Viet Cong.
"The Great Vietnamese Novel(Port)Nguyen's Complaint"
Northern California, during the violent end of the 1960s. At the start of summer, a lonely and thoughtful teenager, Evie Boyd, sees a group of girls in the park and is immediately caught by their freedom, their careless dress, their dangerous aura of abandon. Soon Evie is in thrall to Suzanne, a mesmerizing older girl, and is drawn into the circle of a soon-to-be infamous cult and the man who is its charismatic leader.
"Amazingly Similar to a Story I Have Heard Before"
Graham Greene's evocative analysis of the love of self, the love of another, and the love of God is an English classic that has been translated for the stage, the screen, and even the opera house. Academy Award-winning actor Colin Firth (The King's Speech, A Single Man) turns in an authentic and stirring performance for this distinguished audio release.
"Colin whispers in my ear, and I melt"
Why exactly Charley Bordelon's late father left her eight hundred sprawling acres of sugarcane land in rural Louisiana is as mysterious as it was generous. Recognizing this as a chance to start over, Charley and her 11-year-old daughter, Micah, say good-bye to Los Angeles. They arrive just in time for growing season but no amount of planning can prepare Charley for a Louisiana that's mired in the past: as her judgmental but big-hearted grandmother tells her, cane farming is always going to be a white man's business.
"Enjoyable story and audio performance."
Why we think it's a great listen: Never before has an author's narration of his fiction been so important to fully grasping the book's impact and global implications. Taking us from Afghanistan in the final days of its monarchy to the present, The Kite Runner is the unforgettable story of the friendship between two boys growing up in Kabul. Their intertwined lives, and their fates, reflect the eventual tragedy of the world around them.
"A Worhty Read"
Richard Brautigan was an original - brilliant and wickedly funny. His books resonated with the 1960s, making him an overnight counterculture hero. Dark, funny, and exquisitely haunting, his final book-length fiction explores the fragile, mysterious shadowland surrounding death. Told with classic Brautigan wit, poetic style, and mordant irony, An Unfortunate Woman assumes the form of a peripatetic journal chronicling the protagonist's travels and oblique ruminations on the suicide of one woman and the death of a close friend from cancer.
Hanka osiagnela w zyciu bardzo duzo: ladne mieszkanie, dobrze prosperujace biuro podrózy, grupe oddanych przyjaciól. Nie czuje sie jednak szczesliwa - ma za soba kilka nieudanych zwiazków i wciaz szuka mezczyzny, z którym bedzie mogla miec dziecko. Kiedy na portalu randkowym poznaje Jacka, Polaka "po przejsciach", który od dwudziestu lat mieszka w Stanach, nie waha sie ani chwili. Mimo ostrzezen przyjaciólek decyduje sie zostawic wszystko swoim braciom i wyjechac na stale do USA.
is piece, set in the year 2024, follows the lovelorn travails of a hapless member of the Hungarian surveillance apparatus.
In the wake of family collapse, a writer and her two young sons move to London. The process of upheaval is the catalyst for a number of transitions - personal, moral, artistic, practical - as she endeavours to construct a new reality for herself and her children. In the city she is made to confront aspects of living she has until now avoided and to consider questions of vulnerability and power, death and renewal, in what becomes her struggle to reattach herself to and believe in life.
Gustav Perle grows up in a small town in Switzerland, where the horrors of the Second World War seem only a distant echo. An only child, he lives alone with Emilie, the mother he adores but who treats him with bitter severity. He begins an intense friendship with a Jewish boy his age, talented and mercurial Anton Zweibel, a budding concert pianist.
The rightful emperor is lost to the world, further from the throne than ever before. The lord of the usurper clan has fallen ill, and further unrest looms. Shikanoko has withdrawn to the farthest reaches of the country, leaving his allies stranded and the Spider Tribe unchecked. Lakes are drying up, rivers receding - have the powers of Heaven abandoned the Eight Islands?
In the aftermath of Algeria's war of independence, Paris was a city rife with suspicion and barely suppressed violence. Amid this tension, Jean, a young writer adrift, met and fell for Dannie, an enigmatic woman fleeing a troubled past. Half a century later, with his old black notebook as a guide, Jean retraces this fateful period in his life, recounting how, through Dannie, he became mixed up with a group of unsavory characters connected by a shadowy crime.
Every dog deserves a forever home, and after being mistreated and given up several times, Wrigley has finally found his. The good-natured, smart mutt now spends his days as the house dog at SunRidge Assisted Living, comforting and doting on 45 seniors. Wrigley has free run of the place - going where he senses he's needed - but his preferred spot is beside his favorite resident, Marjorie Thompson.
I had an uncle who left his hometown and the family business there to become a fine actor. His talent was a minor one, but a pretty one. It lasted for 15 years and was gone. He came home with the ashes of it and died 20 years later, poor and, as it happened, drunk.
The corridor of the Fine Arts Building was deserted, save for two figures at the far end, two men approaching slowly. Rose was about to go into the classroom, where she'd left her purse, when she saw a sign on the door - a crude sign in pencil, on a ragged sheet of paper. "Collapse of Western Civilization - Dr. Norbert Beilstein," it said. "Visitors welcome."
Donald believes he knows all there is to know about seeing. An optician in suburban Boston, he rests assured that he and his wife, Viv, who works at the local stables, will live out quiet lives with their two children. Then Mercury - a gorgeous young racehorse - enters their lives, and everything changes.
A young monk discovers a secret doorway buried deep beneath the monastery fields. Forbidden to explore further, Brother Magnus' curiosity drives him on, and with help from a local girl he uncover secrets and surprises from a different time and civilisation.
A Modern Pilgrim's Progress. A man dreams that a giant roller moves over the city, crushing everything in its path in the name of progress. Behind it unfolds a wide road. The man knows he must follow this road into the future to try to find his missing children.
To Kill a Mockingbird is basically a book about growing up under unusual circumstances during the 1930s in the southern United States. The novel's story stretches over three years, during which the major characters experience major changes. To Kill a Mockingbird takes place in the years 1933-35, in the very old town of Maycomb, the seat of Maycomb County, Alabama. It is narrated by a little girl called Jean Louise "Scout" Finch, who is also the main character.
When Jess' daughter, Anna, is reported lost in an avalanche, everything changes. Jess' first instinct is to protect Rose, Anna's five-year-old daughter. But then she starts to uncover Anna's other life - and unearths a secret that alters their whole world irrevocably. The perfect emotional and absorbing story for fans of Jojo Moyes and David Nicholls.
A Hunger Artist. the last book Kafka prepared for publication, was printed after Kafka's death. The protagonist, a hunger artist who experiences the decline in appreciation of his craft, is an archetypical creation of Kafka: an individual marginalized and victimized by society at large.
Danny's World is the story of Danny, an amazing handicapped boy who won the fight to overcome the stigma of being a disabled or handicapped child following the Great Depression. The power of superstition and fear held sway over the lives of families with special children until they met Danny.
Ai-Ming tells the story of her family in revolutionary China, from the crowded teahouses in the first days of Chairman Mao's ascent to the events leading to the Beijing demonstrations of 1989. It is a history of revolutionary idealism, music and silence, in which three musicians - the shy and brilliant composer, Sparrow; the violin prodigy, Zhuli; and the enigmatic pianist, Kai - struggle during China's relentless Cultural Revolution to remain loyal to one another and to the music they have devoted their lives to.
This summary of Catcher in the Rye provides and in depth overview of J.D. Salinger's best-known work. You will get to know the main character Holden Caulfield and journey with him as he learns the important lessons of growing up.
Penobscot Indian Molly Ayer is close to "aging out" out of the foster care system. A community-service position helping an elderly woman clean out her home is the only thing keeping Molly out of juvie and worse.... As she helps Vivian sort through her possessions and memories, Molly learns that she and Vivian aren't as different as they seem to be. A young Irish immigrant orphaned in New York City, Vivian was put on a train to the Midwest with hundreds of other children whose destinies would be determined by luck and chance.
"Moving story of sharing and transformation."
Hailed by The New York Times as "a marvel of storytelling", The Things They Carried's portrayal of the boots-on-the-ground experience of soldiers in the Vietnam War is a landmark in war writing. Now, three-time Emmy Award winner-Bryan Cranston, star of the hit TV series Breaking Bad, delivers an electrifying performance that walks the book's hallucinatory line between reality and fiction and highlights the emotional power of the spoken word.
"Heavy Load"
Golden Globe-winning actor Michael C. Hall (Six Feet Under) performs Truman Capote's masterstroke about a young writer's charmed fascination with his unorthodox neighbor, the "American geisha" Holly Golightly. Holly - a World War II-era society girl in her late teens - survives via socialization, attending parties and restaurants with men from the wealthy upper class who also provide her with money and expensive gifts. Over the course of the novella, the seemingly shallow Holly slowly opens up to the curious protagonist.
""Better to look at the sky than live there""
The year is 1984 and the city is Tokyo.
A young woman named Aomame follows a taxi driver's enigmatic suggestion and begins to notice puzzling discrepancies in the world around her. She has entered, she realizes, a parallel existence, which she calls 1Q84 - "Q" is for "question mark". A world that bears a question....
"Slow, Strange, and (ultimately) Satisfying"
Of all of John Irving's books, this is the one that lends itself best to audio. In print, Owen Meany's dialogue is set in capital letters; for this production, Irving himself selected Joe Barrett to deliver Meany's difficult voice as intended. In the summer of 1953, two 11-year-old boys – best friends – are playing in a Little League baseball game in Gravesend, New Hampshire. One of the boys hits a foul ball that kills the other boy's mother. The boy who hits the ball doesn't believe in accidents; Owen Meany believes he is God's instrument. What happens to Owen after that 1953 foul ball is extraordinary and terrifying.
"The Best ever audio book"
When Jacob and Wilhelm Grimm published their Children's and Household Tales in 1812, followed by a second volume in 1815, they had no idea that such stories as "Rapunzel", "Hansel and Gretel", and "Cinderella" would become the most celebrated in the world. Yet few people today are familiar with the majority of tales from the two early volumes, since in the next four decades the Grimms would publish six other editions, each extensively revised in content and style.
"Once upon a time when a stepmom was only a mom..."
Academy Award winner Dustin Hoffman gives an understated and exemplary performance of this satiric look at the unreality of American media culture. Chance, the enigmatic gardener, becomes Chauncey Gardiner after getting hit by a limo belonging to a Wall Street tycoon. The whirlwind that follows brings Chance to his new status of political policy advisor and possible vice presidential candidate. His garden-variety political responses, inspired by television, become heralded as visionary, and he is soon a media icon.
"Darkly Funny"
Recipient of the 1966 Tanizaki Prize, it has been called Endo's supreme achievement" and "one of the twentieth century's finest novels". Considered controversial ever since its first publication, it tackles the thorniest religious issues of belief and faith head on. A novel of historical fiction, it is the story of a Jesuit missionary sent to seventeenth century Japan, who endured persecution that followed the defeat of the Shimabara Rebellion.
The setting is the Georgia wilderness, where the state's most remote white-water river awaits. In the thundering froth of that river, in its echoing stone canyons, four men on a canoe trip discover a freedom and exhilaration beyond compare. And then, in a moment of horror, the adventure turns into a struggle for survival as one man becomes a human hunter who is offered his own harrowing deliverance.
""A river runs through it...""
It is 1866 and Walter Moody has come to make his fortune upon the New Zealand goldfields. On arrival, he stumbles across a tense gathering of 12 local men, who have met in secret to discuss a series of unsolved crimes. A wealthy man has vanished, a whore has tried to end her life, and an enormous fortune has been discovered in the home of a luckless drunk. Moody is soon drawn into the mystery: a network of fates and fortunes that is as complex and exquisitely patterned as the night sky.
"Not So Luminous"
The richest, most depraved man on Earth, Malachi Constant, is offered a chance to take a space journey to distant worlds with a beautiful woman at his side. Of course, there's a catch to the invitation....
"Absolutely Outstanding"
The year is 1973. As a freak winter storm bears down on an exclusive, affluent suburb in Connecticut, cars skid out of control, men and women swap partners, and their children experiment with sex, drugs, and even suicide. Here two families, the Hoods and the Williamses, com face-to-face with the seething emotions behind the well-clipped lawns of their lives-in a novel widely hailed as a funny, acerbic, and moving hymn to a dazed and confused era of American life.
"A Stark and Dormy Night"
Set on the French Riviera in the late 1920s, Tender Is the Night is the tragic romance of the young actress Rosemary Hoyt and the stylish American couple Dick and Nicole Diver. A brilliant young psychiatrist at the time of his marriage, Dick is both husband and doctor to Nicole, whose wealth goads him into a lifestyle not his own, and whose growing strength highlights Dick's harrowing demise. A profound study of the romantic concept of character - lyrical, expansive, and hauntingly evocative.
"Was it all just the champagne"


text:
1/2 cup pearled barley
1 3½–4-lb. chicken
Kosher salt, freshly ground black pepper
3 garlic cloves, peeled, left whole
3 sprigs thyme
1 bay leaf
1 tablespoon olive oil
1/4 cup brandy or dry white wine
3 carrots, sliced 3" thick
2 leeks, whites and light greens only, trimmed, sliced 3" thick
1 bunch peeled whole baby turnips or one larger turnip (about 6 oz.), peeled, cut into 1" wedges
1 tablespoon chopped fresh chives


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Fairfax, VAUSA
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Fan of geeky tv and games.
Pixels? (Not really a computer gamer)
No-lean more toward the Starbuck side of things (especially in the original series).
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Today during the first hour we heard music from Azerbaijan, Iran. It is another part in the series on the ethnic music of Iran, produced by Dan Rein and Baktash Boghrati.
During the second hour, Pam Guthrie of the Earthtones vocal group was a guest.
Community Lovefest Mix
Pledge Show #2 with Ron Thums of Radio Rumpus Room. Funky Frauleins, Fred Bongusto, The Bobby Havana Boys, and MORE!
Let's try this April Fool idea one more once
Special Spring Pledge Drive edition of Kinda Cloudy Radio! DJs Larry Englund Miguel Vargas join Steely in the studio for two hours of funky sounds on vinyl records. Featuring music from The Violinaires, James Brown, Heatwave, Rick James, The Parliaments, The Soul Sisters, Freddie Scott and much more…
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@MISC{Reif94anefficient, author = {J. H. Reif and S. Sen}, title = {An efficient output-sensitive hidden-surface removal algorithm for polyhedral terrains}, year = {1994}}
In this paper, we present an algorithm for hidden surface removal for a class of poly-hedral surfaces which have a property that they can be ordered relatively quickly. For example, our results apply directly to terrain maps. A distinguishing feature of our algorithm is that its running time is sensitive to the actual size of the visible image, rather than the total number of intersections in the image plaue which can be much larger than the visible image. The time complexity of this algorithm is O((k + n) log ' n) where n and /c are, respectively, the input and the output sizes. Thus, in a significant number of situations this will be faster than the worst case optimal algorithms which have running time of n(n²) irrespective of the output size.
efficient output-sensitive hidden-surface removal algorithm
polyhedral terrain
visible image
output size
actual size
distinguishing feature
poly-hedral surface
significant number
case optimal algorithm
total number
running time
time complexity
hidden surface removal
image plaue
Developed at and hosted by The College of Information Sciences and Technology
© 2007-2016 The Pennsylvania State University


text:
- Working-Class Perspectives offers weekly commentaries on current issues related to working-class people and communities. Contributors discuss a variety of issues, from what class means to how it intersects with race and gender to how class is shaping American politics. We welcome relevant comments of 500 words or less.
For questions or comments about this blog, e-mail Sherry Linkon. For assistance with news stories about working-class politics and culture, call or e-mail John Russo, 330-207-8085.
The State of the Working ClassListen to Working-Class Perspective editor Sherry Linkon's recent interview about Working-Class Studies on KERA's Think with Krys Boyd.
Tag Archives: working-class voters
Why Clinton Could Lose the Working Class in Ohio
Note: As the Republican National Convention gets underway in Cleveland, we're reposting John Russo's recent op-ed explaining why Hillary Clinton could lose working-class voters in Ohio and what she would need to do in order to win. The piece first … Continue reading
A Working-Class Brexit
I woke up Friday morning to the news that my country decided that it no longer wants to be part of the European Union. With a large turnout of 72% of the eligible electorate, the vote went 51.9% in favour … Continue reading
From Paula Jones to Trailer Parks: Journalists' Class Blind Spots
In 1996, James Carville was asked what he thought about Paula Jones's claims of being sexually assaulted by Bill Clinton. He said, "Drag a hundred-dollar bill through a trailer park, you never know what you'll find." The liberal press … Continue reading
Redefining the Working Class
Once again, a presidential election is bringing renewed interest in the working class, especially the white working class. Are they a racist bulwark of Trump support? Will they support a Clinton, after NAFTA and welfare reform? Do they represent a … Continue reading
Misrepresenting the White Working Class: What the Narrating Class Gets Wrong
Most of the time the white working class is invisible in the U.S. But during elections there is a flurry of attention to this "demographic" among political reporters and operatives, and as a result, also among the millions of us … Continue reading
A New Leader for Labour in the UK
Last Saturday, Jeremy Corbyn was elected the new leader of the UK Labour Party after a summer long campaign. Corbyn's name may not be familiar to many readers. To be honest, few outside the supporters of left wing causes in … Continue reading
Stereotyping White Working-Class Voters
Analysis of the Democrats' 2014 electoral debacle has again turned toward their chronic and worsening "problem with the white working class." For the most part, pieces like those in Mother Jones, Slate, The Nation, and even Thomas Edsall in The … Continue reading


text: Lovely meal, we were able to eat in the bar with the dogs. Same menu as in the restaurant and very cozy. Will go again. Plenty of parking, real fire. Brilliant (friendly staff). Was far to full after our main meal but the dessert menu looked scrummy. Will definitely eat in the countryside pub again!


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"It has been a long time since I read anything this vivid, dramatic, and moving. Literally, tears came to my eyes. So much dedication and bravery. The compelling true-life stories are far more gripping and inspiring than any novelist could invent." David Morrell, New York Times bestselling author of First Blood and The Brotherhood of the Rose
"A simply great book... Funny, sad, and, at times, haunting... Some of these fifty-five stories are lyrical, some are gritty, some so heartbreaking they make you cough up a tear and others are laugh-out-loud funny. And some are more thrilling than top suspense fiction. But they all come right from the heart that beats beneath the badge." New York Daily News on True Blue: Police Stories by Those Who Have Lived Them
"If you want to enter the hearts and minds of the men and women sworn to protect us, read True Blue. These intimate episodes, written by the law officers who lived them, are funny, sad, moving, and powerful.... Everybody should own this memorable book." Joseph Wambaugh, author of The Onion Field and Hollywood Station on on True Blue: Police Stories by Those Who Have Lived Them
"If you want an adrenaline rush, forget about intricate mysteries and so-called thrillers. These pages bring to vivid reality the real stories of cops whose guts and glory are seldom seen and rarely heard." John Langley, creator of COPS on True Blue: Police Stories by Those Who Have Lived Them


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The Whole Nine Yards
What parents need to know
Parents Need to Know
Parents need to know that this movie is rated R for language, sexual references and situations (including sex used as a negotiating technique), substance abuse (including liquor used to cope with problems), and violence (including the death of a major character).
User reviews
Parents say
Kids say
What's the story?
THE WHOLE NINE YARDS stars Matthew Perry as Oz, a miserable dentist from Chicago, now living in Canada with a wife (Rosanna Arquette) who despises him. He is trying to pay off the debts of her father, who had been his partner, and who embezzled money and then committed suicide. When the notorious Jimmy "The Tulip" Tedeski (Bruce Willis) moves next door, Oz becomes involved in a series of double- and triple-crosses, involving Jimmy's former colleagues in the mob, an assortment of hired killers, and Jimmy's beautiful and lonely wife, Cynthia (Natasha Henstridge).
Is it any good?
There is a nice little comedy genre about mob hit men living in suburbia; this one doesn't quite live up to Steve Martin's neglected gem My Blue Heaven, but it has some very funny moments.
The Whole Nine Yards is a fast and funny comedy that checks morality and political correctness at the door. Perry spends most of his time falling down, when he isn't getting beat up. Amanda Peet is simply terrific as Oz's sympathetic receptionist, with an unexpected expertise in hired killers. And the resolution, following a tough choice between love or money, is very satisfying.
Families can talk about...
Families can talk about the various ways the mob is portrayed in movies, and research the true history of the mafia.
Movie details
|Theatrical release date:
|February 18, 2000
|DVD release date:
|July 18, 2000
|Bruce Willis, Matthew Perry, Michael Clarke Duncan
|Jonathan Lynn
|Warner Bros.
|Run time:
|98 minutes
|MPAA rating:
|MPAA explanation:
|some sexuality/nudity and violence
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Hubcap Heaven Inc.
Phone: (216) 252-1994 Fax: (216) 688-1994 View Additional Phone Numbers 13840 Bellaire Rd, Cleveland, OH 44135 View Additional Email Addresses http://www.hubcaps-wheelcovers.com
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text:
plato audio books download free idb4 MegaFiles
Detailed Description plato audio books
File name: plato_audio_books.zip
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2/5/2013 · Plato's republic - FULL Audio Book - Part 1 of 2 - by Plato (427-347) Buy Plato's Republic here at http://amzn.to/1AU29Ss SUBSCRIBE to https://www.youtube ...4/1/2013 · PLATO: Protagoras - FULL AudioBook | Greatest Audio Books Philosophy & Philosophers - Protagoras (Greek: Πρωταγόρας, ca. 490 BC -- 420 BC) was a ...Project Gutenberg offers 48,544 free ebooks for Kindle, iPad, Nook, Android, and iPhone.Amazon.com: Plato: Complete Works (8601401282075): Plato, John M. Cooper, D. S. Hutchinson: BooksThe Republic Of Plato: Second Edition and over one million other books are available for Amazon Kindle. Learn moreThe Allegory of the Cave From Book VII of the Republic WRITTEN BY: Plato. NARRATED BY: Michael Scott. Plato's description of what it is like to be ...The Apology (Apologia Socratis) is Plato's version of the speech given by Socrates as he defended himself in 399 BC against the charges of "corrupting the young, and ...The Republic is an influential work of philosophy and political theory by the Greek philosopher Plato, written in approximately 360 BC.differences. By wang yan - 2006-08-27 06:49. The audio file is different fro from he script.The announcer missed some part of some sentences.IT is annoying,but anyway ...Free kindle book and epub digitized and proofread by Project Gutenberg.
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The Lumbar is our mens' Heritage high pile fleece lined check shirt. It's cut with a relaxed Lifestyle Fit from airy Coolweave cotton with a cosy high-pile lining around the body for added warmth. With its earthy autumnal colours and classic styling you can confidently wear it down the pub or to chop fireside logs.Read more...
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Has anyone tried the Tzone vibration machines?
Tzone".vibration therapy
flowAjen central, NJ(Zone 6b) Mar 02, 2010
Not me.
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1724 briefings from 411 companies
Regulation briefings
Regulation - Briefings related to Regulation
Human rights as a corporate responsibility are still fairly immature, with concepts around business complicity still evolving. We look at how the best companies are integrating human rights risk, and where some have so memorably got it wrong. At EdenTree, we have been a vocal part of the engagement
Published:11 May 2016
Business Area:Governance and management
The need for a sustainable retirement income has not been removed by Pension Freedom, but with freedom also comes responsibility to choose the right options. This Breakfast Briefing explores the opportunities for financial advice in the new retirement landscape. Click download for more information.
Published:04 March 2015
Business Area:Retirement
George Osborne himself described the changes to the pensions regime as "the most far-reaching reform to the taxation of pensions since the regime was introduced in 1921". This paper explores how some of these changes have opened up opportunities for advisers and their clients.
Published:09 February 2015
Business Area:Retirement
This guide explores how professional advisers can adapt their pre-budget advice processes to accommodate the new retirement options.
Published:15 January 2015
Business Area:Retirement
After more than a year of RDR being in place, we sat down with four financial advice firms from across the UK to see how they have adapted their business – and to gauge their thoughts on a post-RDR landscape.
Published:21 November 2014
Business Area:Regulation
This FCA guidance addresses the potential for adviser remuneration to distort the advice consumers receive. It is relevant to all providers of retail investment products to be sold by advisers and any advisory firm providing personal recommendations in relation to retail investment products.
Company:FCA (Financial Conduct Authority)
Published:12 March 2014
Business Area:Regulation
Investment managers should invest a significant portion of their investible wealth and total remuneration alongside that of their investors, in order to bring clients' interests into line with their own, according to a new report by the prominent London and Paris based financial services think tank,
Company:New City Initiative
Published:28 August 2013
Business Area:Investment
The Retail Distribution Review is nearly upon us and it certainly has been a long time coming. Committed to helping advisers transition their business as efficiently as possible to whichever business model they have decided is best for them and their clients in the post-RDR world, Threadneedle have
Company:Protected Product Review
Published:08 October 2012
Business Area:Equities
Predicting the next mis-selling crisis has always been a difficult task and FSA have accepted that they will never achieve this. Instead, they are opting for a more aggressive and interventionist model which seeks to prevent major mis-selling scandals in the future.
Company:Consulting Consortium
Published:06 June 2012
Business Area:Active
In a welcomed decision for the derivatives market and the users of the ISDA Master Agreement, the English Court of Appeal recently handed down its judgment in four related cases including Lomas and others v JFB Firth Rixson Inc. Baker & McKenzie summarise the key points to take away.
Company:Baker & McKenzie
Published:02 May 2012
Business Area:Legal
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+44 (0)1244 689999
Clients from global brand names to dynamic start-ups
We blend over three decades of marketing expertise with creative flair and imagination to produce outstanding solutions.
From our base in the North West of England, BZ Marketing have been enhancing the value and reputation of our clients' many brands for years. Over 29 years, in fact.
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That, we are pleased to say, is why so many of our clients have stayed with us for so long.


text:
Current Treatment Options in Cardiovascular Medicine
, Volume 14, Issue 5, pp 503-519
First online:
Left Atrial Appendage Occlusion and Ligation Devices: What Is Available, How to Implement Them, and How to Manage and Avoid Complications
- Arash AryanaAffiliated withRegional Cardiology Associates and Mercy Heart & Vascular Institute
- , Eduardo B. SaadAffiliated withCenter for Atrial Fibrillation, Hospital Pró-Cardíaco
- , André d'AvilaAffiliated withHelmsely Cardiac Arrhythmia Service, Mount Sinai School of Medicine Email author
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Opinion statement
Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide, and it is associated with an elevated risk of thromboembolic events, including ischemic stroke. Evidence suggests that at least 90 % of left atrial thrombi discovered in patients with AF are localized to the left atrial appendage (LAA). Surgical ligation or excision of the LAA is considered the standard of care in patients who undergo mitral valve surgery or as an adjunct to a surgical Maze procedure for treatment of AF. In addition, in selected patients with AF and an elevated risk of thromboembolic events, particularly in those with contraindication to oral anticoagulation (OAC) therapy, it is reasonable to consider LAA exclusion to offer protection against ischemic stroke and other embolic complications. This can be achieved through a number of different strategies, including surgical amputation or ligation of the LAA, percutaneous endocardial occlusion of the LAA by deployment of occlusive devices, and also ligation of the LAA via a closed-chest, percutaneous, epicardial catheter-based approach in select patients. Although results from several recent percutaneous LAA closure and ligation studies are highly promising, the evidence for long-term efficacy and safety is insufficient to presently recommend this approach to all patients other than those in whom long-term OAC is contraindicated. Future randomized studies are required to further address the long-term safety and efficacy of these therapeutic options. Finally, the role for LAA occlusion and ligation seems less clear in patients who undergo successful catheter ablation of AF, since at least in a subgroup of these patients antiplatelet therapy alone has been shown to be sufficient.
KeywordsAtrial fibrillation Catheter ablation Device implant Left atrial appendage Ligation Oral anticoagulation Stroke
Reference tools
- Title
- Left Atrial Appendage Occlusion and Ligation Devices: What Is Available, How to Implement Them, and How to Manage and Avoid Complications
- Journal
Current Treatment Options in Cardiovascular Medicine
Volume 14, Issue 5 , pp 503-519
- Cover Date
- 2012-10
- 10.1007/s11936-012-0203-8
- Print ISSN
- 1092-8464
- Online ISSN
- 1534-3189
- Publisher
- Current Science Inc.
- Additional Links
- Topics
- Keywords
- Atrial fibrillation
- Catheter ablation
- Device implant
- Left atrial appendage
- Ligation
- Oral anticoagulation
- Stroke
- Industry Sectors
- Authors
- Arash Aryana MD (1)
- Eduardo B. Saad MD (2)
- André d'Avila MD, PhD (3)
- Author Affiliations
- 1. Regional Cardiology Associates and Mercy Heart & Vascular Institute, Sacramento, CA, USA
- 2. Center for Atrial Fibrillation, Hospital Pró-Cardíaco, Rio de Janeiro, RJ, Brazil
- 3. Helmsely Cardiac Arrhythmia Service, Mount Sinai School of Medicine, One Gustave L. Levy Place–, Box 1030, New York, NY, 10029, USA


text:
Top Definition
the act of tucking onself into a ball and then propelling onself off of the board of diving and into one's pool.
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de kim an' dyllie 23 Octombrie 2003
Trending Now
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E-mailurile sunt trimise de la firstname.lastname@example.com. Nu-ți vom trimite mesaje nedorite.×


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|Publication number
|Publication type
|Application number
|Publication date
|Dec 22, 1998
|Filing date
|Feb 3, 1998
|Priority date
|Feb 3, 1998
|Fee status
|Also published as
|Publication number
|John C. Brahms, Shirley A. Lucchesi, Frederick G. Saunders, Abdul Gaffar, Stuart Shapiro
|Original Assignee
|Colgate Palmolive Company
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (14), Non-Patent Citations (4), Referenced by (2), Classifications (11), Legal Events (6)
|External Links: USPTO, USPTO Assignment, Espacenet
1. Field of the Invention
This invention relates to an antibacterial antiplaque oral composition containing a substantially water insoluble, noncationic antibacterial phenolic compound which is more fully described below.
2. The Prior Art
Dental plaque is a soft deposit which forms on teeth as opposed to calculus which is a hard calcified deposit on teeth. Unlike calculus, plaque may form on any part of the tooth surface, particularly including at the gingival margin. Hence, beside being unsightly, it is implicated in the occurrence of gingivitis.
Cationic antibacterial materials such as chlorhexidine, benzthonium chloride and cetyl pyridinium chloride have been used by the art as antibacterial antiplaque agents in oral compositions. However, such agents are generally not effective when used with anionic materials ingredients such as anionic surfactants required for the effective performance of oral compositions such as toothpaste and mouthrinses. Noncationic antibacterial materials can be compatible with anionic components in an oral composition and noncationic halogenated hydroxydiphenyl ethers such as Triclosan have been effectively employed in oral compositions as antibacterial antiplaque agents when admixed with neutral materials such as humectants, abrasives and thickeners used in the formulation of oral compositions.
Phenol and alkyl substituted phenols are well known and widely used antimicrobials. However, it is difficult to predict the functionality of these antimicrobials as antiplaque agents when incorporated in oral composition vehicles. For example, thymol (2-isopropyl-5-methylphenol) is an active antimicrobial agent in commercial mouthrinse formulations, but its antibacterial activity is considered relatively low and possibly insufficient, its activity for example being only a small fraction of the activity of Triclosan.
In accordance with the present invention there is provided an oral antiplaque composition comprising an orally acceptable vehicle and an effective antiplaque amount of at least one substantially water insoluble noncationic adamantyl-substituted phenolic antibacterial agent having the following formulae: ##STR2## and mixtures thereof.
While adamantyl substituted phenolic compounds are known (Chemical Abstracts Registration Numbers 41031-50-9 and 29799-07-3) their use as antiplaque agents delivered in an orally acceptable vehicle is not known to the prior art.
The adamantyl substituted phenolic compound is incorporated in the oral compositions of the present invention in a non-toxic, effective antiplaque amount, typically in a range of about 0.003 to about 5%, preferably about 0.005 to about 3%, more preferably about 0.02 to about 1% by weight.
To enhance the antibacterial activity of the adamantyl-substituted phenolic antibacterial agent, an antibacterial enhancing agent may be included in the oral composition. The use of such antibacterial enhancing agents in combination with water-insoluble noncationic antibacterial compounds is known to the art, as for example, U.S. Pat. Nos. 5,188,821 and 5,192,531.
Antibacterial enhancing agents preferred for use in the practice of the present invention include a natural or synthetic anionic polymeric polycarboxylate having a molecular weight of about 1,000 to about 5,000,000, preferably about 30,000 to about 500,000. Synthetic anionic polymeric polycarboxylates are generally employed in the form of their free acids or preferably partially or more preferably fully neutralized water soluble alkali metal (e.g. potassium and preferably sodium) or ammonium salts. Preferred are 1:4 to 4:1 copolymers of maleic anhydride or acid with another polymerizable ethylenically unsaturated monomer, preferably methyl vinyl either/maleic anhydride having a molecular weight (M.W.) of about 30,000 to about 1,000,000, most preferably about 30,000 to about 500,000. These copolymers are available, for example, as Gantrez�, AN 139 (M.W. 500,000), AN 119 (M.W. 250,000); and preferably S-97 Pharmaceutical Grade (M.W. 70,000), of GAF Corporation.
Other polymeric polycarboxylates useful in the practice of the present invention include the 1:1 copolymers of maleic anhydride with ethyl acrylate, hydroxyethyl methacrylate, N-vinyl-2-pyrollidone, or ethylene, the latter being available, for example, as Monsanto EMA� No: 1103, M.W. 10,000 and Grade 61, and 1:1 copolymers of acrylic acid with methyl or hydroxyethyl methacrylate, methyl or ethyl acrylate, isobutyl methacrylate, isobutyl vinyl ether or N-vinyl-2-pyrrolidone.
Additional operative useful polycarboxylate compounds include copolymers of maleic anhydride with styrene, isobutylene or ethyl vinyl either, polyacrylic, polyitaconic and polymaleic acids, and sulfonacrylic oligomers of M.W. as low as 1,000 available as Uniroyal� ND-2.
Also useful in the practice of the present invention are the so-called carboxyvinyl polymers, commercially available, for example, under the trademarks Carbopol� 934, 940 and 941 from B. F. Goodrich, these polymers consisting of a colloidally water-soluble polymer of polyacrylic acid crosslinked with from about 0.75% to about 2.0% of polyallyl sucrose or polyallyl pentaerythritol as a cross linking agent, often with M.W.'s up to 4-5 million or more.
The antibacterial enhancing agent, when employed, is incorporated in the compositions of the present invention in weight amounts of about 0.05 to about 5%, preferably about 0.1 to about 3%.
Linear molecularly dehydrated polyphosphate salts can be optionally employed herein as anticalculus agents. They are well known, being generally employed in the form of their wholly or partially neutralized water soluble alkali metal (e.g. potassium or preferably sodium) or ammonium salts, and any mixtures thereof. Representative examples include sodium tripolyphosphate, monosodium triacid,-, disodium diacid-, trisodium monoacid-, and tetrasodium-pyrophosphates, the corresponding potassium salts and the like. In the present invention, they can be employed in the oral compositions in approximate weight amounts of about 0.1 to about 3%, typically about 1 to about 2.5%, more typically about 1.5 to about 2%, especially about 2%. Particularly desirable anticalculus agents are tetraalkali metal pyrophosphates such as tetrasodium and tetrapotassium pyrophosphates, and mixtures thereof.
Fluoride ions may desirably also be included in the oral compositions of the present invention to provide an anticaries effect. Among these materials are inorganic fluoride salts, such as soluble alkali metal fluoride salts, for example, sodium fluoride, potassium fluoride, ammonium fluoride, sodium monofluorophosphate, and sodium hexafluorosilicate. Alkali metal and tin fluorides, such as sodium and stannous fluorides, sodium monofluorophosphate and mixtures thereof, are preferred.
The amount of fluorine-providing salt is generally present in the oral composition at a concentration of about 0.0005 to about 3.0% by weight. Any suitable minimum amount of such salt may be used, but it is preferable to employ sufficient fluoride salt to release about 300 to 2,000 ppm, more preferably about 800 to about 1.500 ppm, of fluoride ion.
The oral composition of the present invention may be a solution of ingredients such as a mouthrinse or it maybe a semi-solid such as a toothpaste or gel dentifrice or chewing gum or solid lozenge.
In the aspect of this invention wherein the oral composition is a gel or paste, an orally acceptable vehicle, including a water-phase with humectant which is preferably glycerine or sorbitol or an alkylene glycol such as polyethylene glycol or propylene glycol is present, wherein water is present typically in an amount of about 15-40% by weight and glycerine, sorbitol and/or the alkylene glycol (preferably propylene glycol) typically total about 20-75% by weight of the oral composition, more typically about 25-60% by weight.
When the oral composition is substantially semi-solid or pasty in character, such as a toothpaste or gel, the dentifrice vehicle may contain a dentally acceptable abrasive material such as sodium bicarbonate or water insoluble abrasive material such as sodium metaphosphate, potassium metaphosphate, tricalcium phosphate, dihydrated dicalcium phosphate, anhydrous dicalcium phosphate, calcium pyrophosphate, calcium carbonate, aluminum silicate, hydrated alumina, calcined alumina, silica, bentonite, and mixtures thereof.
The abrasive material is generally present in the paste or gel composition in weight concentrations of about 10% to about 60% by weight, preferably about 10% to about 30% in a gel and about 25% to about 60% in a paste.
Toothpastes as well as gel dentifrices typically contain a natural or synthetic thickener or gelling agent in proportions of about 0.1 to about 10% by weight, preferably about 0.5 to about 5% by weight. Suitable thickeners or gelling agents include Irish moss, iota-carrageenan, kappa-carrageenan, gum tragacanth, starch, polyvinylpyrrolidone, hydroxyethyl propyl cellulose, hydroxybutyl methyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose and sodium carboxymethyl cellulose.
In the aspect of the present invention wherein the oral composition is substantially liquid in character such as a mouthwash or rinse, the vehicle is typically a water-alcohol mixture. Generally, the weight ratio of water to alcohol is in the range of from about 3:1 to 10:1 and preferably about 4:1 to about 6:1. The alcohol is a non-toxic alcohol such as ethanol or isopropanol. A humectant such as glycerine, sorbitol or an alkylene glycol such as polyethylene glycol or preferably propylene glycol may be present in amount of about 10-30% by weight. Mouthrinses typically contain about 50-85% of water, about 0 to 20% by weight of a non-toxic alcohol and about 10-40% by weight of the humectant.
Organic surface-active agents are used in the compositions of the present invention to achieve increased prophylactic action and assist in achieving thorough and complete dispersion of the adamantyl substituted phenolic antibacterial agent throughout the oral cavity. The organic surface-active material is preferably anionic, suitable examples which include water-soluble salts of higher fatty acid monoglyceride monosulfates, such as the sodium salt of the monosulfated monoglyceride of hydrogenated coconut oil fatty acids, higher alkyl sulfates such as sodium lauryl sulfate, alkyl aryl sulfonates such as sodium dodecyl benzene sulfonate, higher alkyl sulfoacetates, higher fatty acid esters of 1,2-dihydroxy propane sulfonate, and the substantially saturated higher aliphatic acyl amides of lower aliphatic amino carboxylic acid compounds, such as those having 12 to 16 carbons in the fatty acid, alkyl or acyl radicals and alkoyl taurines, and the like. Examples of the last mentioned amides and taurates are N-lauroyl sarcosine, and the sodium, potassium and ethanolamine salts of N-lauroyl, N-myristoyl, or N-palmitoyl sarcosine which should be substantially free from soap or similar higher fatty acid material as well as N-methyl-N-cocoyl (or oleoyl or palmitoyl) taurines.
Any suitable flavoring or sweetening material may also be employed. Examples of suitable flavoring constituents are flavoring oils, e.g. oil of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, cinnamon, lemon, and orange, and methyl salicylate. Suitable sweetening agents include sucrose, lactose, maltose, xylitol, sodium cyclamate, perillartine, aspartyl phenyl alanine methyl ester, saccharine and the like. Suitably, flavor and sweetening agents may each or together comprise from about 0.1% to 5% or more of the preparation.
Agents used to diminish teeth sensitivity such as strontium chloride, potassium nitrate and potassium citrate can also be included in the oral compositions of the present invention at concentrations of about 0.1 about 10% by weight.
Various other materials may be incorporated in the oral compositions of this invention including whitening agents such as urea peroxide, hydrogen peroxide, preservatives, such as sodium benzoate, vitamins and chlorophyll compounds. These adjuvants, when present, are incorporated in the compositions in amounts which do not substantially adversely affect the properties and characteristics desired.
The oral compositions of the present invention may be prepared by suitably mixing the ingredients. For instance, in the preparation of a mouthrinse, the adamantyl substituted phenolic antibacterial agent is dispersed in a mixture of ingredients, e.g. alcohol, humectants, surfactants, and salts such as sodium fluoride and flavor are then added and mixed. The ingredients are then mixed under vacuum for about 15-30 minutes. The resulting rinse product is then packaged. Dentifrices are prepared similarly, additional thickener and polishing agents being included in the last or penultimate step.
The compositions of this invention can be incorporated in lozenges, or in chewing gum or other products, e.g. by stirring into a warm gum base or coating the outer surface of a gum base, illustrative of which may be mentioned jelutone, rubber latex and vinylite resins desirably with conventional plasticizers or softeners, sugar or other sweeteners or carbohydrates such as glucose, sorbitol and the like.
The vehicle or carrier in a tablet or lozenge is a non-cariogenic solid water-soluble polyhydric alcohol (polyol) such as mannitol, xylitol, sorbitol, malitol, a hydrogenated starch hydrolysate hydrogenated glucose, hydrogenated disaccharides or hydrogenated polysaccharides, in an amount of about 90 to 98% by weight of the total composition. Salts such as sodium bicarbonate, sodium chloride, potassium bicarbonate or potassium chloride may totally or partially replace the polyol carrier. Tableting lubricants, in minor amounts of about 0.1 to 5% by weight, may be incorporated into the tablet or lozenge formulation to facilitate the preparation of both the tablets and lozenges. Suitable lubricants include vegetable oils such as coconut oil, magnesium stearate, aluminum stearate, talc, starch and Carbowax�.
Lozenge formulations contain about 2% gum as a barrier agent to provide a shiny surface as opposed to a tablet which has a smooth finish. Suitable non-cariogenic gums include kappa carrageenan, carboxymethyl cellulose, hydroxyethyl cellulose, Gantrez�, and the like.
The lozenge or tablet may optionally be coated with a coating material such as waxes, shellac, carboxymethyl cellulose, polyethylene/maleic anhydride copolymer or kappa-carrageenan to further increase the time it takes the tablet or lozenge to dissolve in the mouth. The uncoated tablet or lozenge is slow dissolving, providing a sustained release rate of active ingredients of about 3 to 5 minutes. Accordingly, the solid dose tablet and lozenge composition of this invention affords a relatively longer time period of contact of the teeth in the oral cavity with the active ingredients.
The following example further illustrates the present invention, but it is understood that the invention is not limited thereto. All amounts and proportions referred to herein and in the appended claims are by weight unless otherwise indicated.
A mouthrinse was prepared using the following ingredients:
______________________________________ Composition A Composition BIngredients (grams) (grams)______________________________________Glycerin (99.7% stock) 10.0 10.000Sorbitol (70% stock) 10.0 10.000Ethanol 15.0 15.0Propylene glycol 15.0 15.0Sodium lauryl sulfate 0.3 0.3Tauranol 0.3 0.300Sodium fluoride 0.243 0.243p-(1-adamantyl)phenol 0.03 --2-(1-adamantyl)-p-cresol -- 0.03______________________________________
The antibacterial efficacy of mouthrinse compositions A and B was evaluated in accordance with a MIC (Minimum Inhibitory Concentration) test which measures the minimum concentration in ppm of the mouthrinse at which the growth of the bacteria is completely inhibited. The smaller the MIC, the greater the antibacterial activity of the mouthrinse being tested. Water is used as a control. These MIC test is more fully described in U.S. Pat. No. 5,275,805 at column 11, lines 54-68, which description is herewith incorporated herein.
The results of the MIC tests are recorded in the table below:
TABLE______________________________________ A. viscosus (MIC in ppm)______________________________________Mouthrinse A 15.6Mouthrinse B 15.6Control (water) <125______________________________________
The results recorded in the Table demonstrate that mouthrinses containing an adamantyl substituted phenol are effective as antiplaque oral compositions.
|Cited Patent
|Filing date
|Publication date
|Dec 16, 1971
|May 13, 1975
|Kao Corp
|Adamantyl-(1)-{62 -naphthol
|Feb 25, 1974
|Aug 5, 1975
|Colgate Palmolive Co
|Ether-linked quaternary ammonium compounds
|Sep 24, 1973
|Dec 23, 1975
|Colgate Palmolive Co
|New quaternary compounds having anti-microbial activity
|Aug 20, 1975
|Nov 16, 1976
|Colgate-Palmolive Company
|Quaternary compounds having anti-microbial activity
|Feb 25, 1974
|Sep 6, 1977
|Colgate Palmolive Company
|Alicyclic amido-quaternary ammonium anti-bacterial agents
|Jun 2, 1977
|Oct 31, 1978
|Colgate-Palmolive Company
|Quaternary compounds having anti-microbial activity
|Jun 2, 1977
|Oct 31, 1978
|Colgate-Palmolive Company
|Quaternary compounds having anti-microbial activity
|Jun 2, 1977
|Oct 31, 1978
|Colgate-Palmolive Company
|Quaternary compounds having anti-microbial activity
|Jun 2, 1977
|Oct 31, 1978
|Colgate-Palmolive Company
|Quaternary compounds having anti-microbial activity
|Jun 2, 1977
|Mar 6, 1979
|Colgate Palmolive Company
|Quaternary compounds having anti-microbial activity
|Oct 12, 1979
|Sep 8, 1981
|Lemelson Jerome H
|Automatic vehicle identification system and method
|Apr 6, 1988
|Apr 10, 1990
|Aromatic derivatives, their preparation and their use as antimicrobial agents
|Jan 24, 1990
|Feb 18, 1992
|Aromatic derivatives and their use as antimicrobial agents
|Mar 29, 1991
|Jun 22, 1993
|Minolta Camera Kabushiki Kaisha
|Video camera having a video signal processing apparatus
|Chem. Abstr. 125:275729 of Arredondo and Biovac Med Chem. Lett 6(15):1781 1784 (Bactericidal Activity of P 1 Adamantyl Phenol) 29799 07 3, 1996.
|Chem. Abstr. 125:275729 of Arredondo and Biovac Med Chem. Lett 6(15):1781-1784 (Bactericidal Activity of P-1-Adamantyl Phenol) 29799-07-3, 1996.
|Chem. Abstr. 83:109072 of AIGAM/ et al J. Med. Chem. 18(7):713 721 Antiviral adamantane Derivatives 2 (1 adamantyl) 4 methylphenol & Adamantyl Phenols, Adamontyl cresols (41031 50 9) (1975).
|Chem. Abstr. 83:109072 of AIGAM/ et al J. Med. Chem. 18(7):713-721 Antiviral adamantane Derivatives 2-(1-adamantyl)-4 methylphenol & Adamantyl Phenols, Adamontyl cresols (41031-50-9) (1975).
|Citing Patent
|Filing date
|Publication date
|Apr 1, 2010
|Jun 3, 2014
|Colgate-Palmolive Company
|Non-aqueous dentifrice composition with bioacceptable and bioactive glass and methods of use and manufacture thereof
|Feb 5, 2007
|Aug 16, 2007
|Whitehill Oral Technologies, Inc.
|Sialagogue based oral care products
|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification
|Oct 5, 1998
Owner name: COLGATE-PALMOLIVE COMPANY, NEW YORK
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BRAHMS, JOHN C.;LUCCHESI, SHIRLEY A.;SAUNDERS, FREDERICKG.;AND OTHERS;REEL/FRAME:009504/0623;SIGNING DATES FROM 19980114 TO 19980121
|Apr 27, 1999
|Certificate of correction
|Jun 17, 2002
|Fee payment
Year of fee payment: 4
|Jul 12, 2006
|Maintenance fee reminder mailed
|Dec 22, 2006
|Lapse for failure to pay maintenance fees
|Feb 20, 2007
|Expired due to failure to pay maintenance fee
Effective date: 20061222


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Erik's life is all but great. At home he gets terrorised by his stepfather who's never pleased with anything he does and as a result he constantly starts to fight with people at school. After having been kicked off several, his last chance for a degree is by going to a private boarding school where the senior students control the younger ones. Once there, he just wants to be left alone and be able to graduate but the seniors aren't all too happy with the fact that he doesn't want to comply with their dictatorial rule.
Sound and Vision:
No problems with the image quality. You might find that there's some detail missing at times but overall we do get a very clear image and compression errors or other disturbances are absent.
Too bad the sound is only 2.0 stereo but for the dialogues it isn't a problem and there aren't too many effects so a 5.1 track wouldn't have done much better in my opinion.
Evil is set mid 20th century in a private boarding school where the (rich) senior students have a dictatorial rule over the others and they love picking on those that are less fortunate. The movie nicely portrays the problems this brings along and the interaction between the different main characters is also shown very well. Although Swedish movies aren't the most popular in the rest of the world, Evil shows that there's some good stuff in Sweden. The acting can be quite unnatural at times but overall the 109 minute movie never bores. People looking for something different certainly should check this one out, if only by renting it.
Eragon 2-Disc SE House M.D. Season 2
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With your new project ready to go, it's time to import your media files. First let's click on File > Get Media from, and in the dialog box you'll see Elements Organizer, which we're going to discuss in another video; various cameras, which we're going to discuss in capturing in the next video. So for this lesson if you have files, video files or audio files, that are on your Desktop or your hard drive, you'd click Files and Folders. Maybe you captured them already or someone handed you the videos or you shot them on your webcam, et cetera, although we have Webcam here, we're going to click here and find them. So Files and Folders.
And in the exercise files if you choose assets, double-click on that. And for this lesson let's just choose dancing, and we're going to import. And now you may get an Add Media Failure and you're going to freak out because you think you're doing things wrong. It's just a certain file extension that Premiere Elements won't accept, but it really is a nonessential file extension, and it's not going to have any problems with you. It's usually from videos that are shot with Canon cameras, some AVCHD.
These are little files that other editing programs may need. Premiere Elements does not, so I'll just click OK. So now my assets are in the Project area. I can double-click on them to see them all. I can choose the List view if I want to look down and see what they are here. I can even show how many times it's been used, here in the Video Usage, Audio Usage, and then this is an area for notes that we can look at later. If you want to check your footage, all you need to do is double-click on it.
It'll open up the Preview area and you can play. You can scrub and make sure this is the correct footage that you want. Premiere Elements 10 allows you to import multiple formats of video and audio assets. You can mix and match them and get ready to make your edit.
- Importing and capturing media
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