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Pet Accessories
9 Adorable Ways to Spoil Your Furry Friend
Originally posted 04/11/2016 06:10PM
Give your furry friend the ultimate VIP treatment with these pampering products
Me-Wow! Kickstarter for Kitty Hamster Wheel Far Exceeds Goal with Nearly $100,000 Funded
Originally posted 07/21/2014 04:45PM
Katherine Heigl: 'I Wouldn't Recommend' Having 7 Dogs and 2 Kids
Originally posted 12/17/2012 08:25AM
An ardent animal lover and advocate, Katherine Heigl has happily opened up her home and heart to seven canine companions – but she's the first to admit it's not always easy.
"Yeah, I wouldn't recommend that," the actress jokes to PEOPLE. "I really love these dogs, but it's a lot with two little kids."
After purchasing her first three dogs – schnauzers Romeo, Stella and Wheezer – Heigl became aware of Los Angeles's growing overpopulation problem, and began rescuing pooches as a result.
Bret Michaels, Pet Accessories Designer? Believe It
Originally posted 06/26/2012 05:45PM
Bret Michaels wanted a dog bed with metal studs.
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The rocker-by-day is speaking as a designer of pet accessories. It's an endeavor he took on with PetSmart this year, and one that's resulted in the firstPets Rock Collection, a line of toys, apparel and beds that are exactly what you might expect from Michaels.
Stars and Their Wild (Animal) Style
Originally posted 06/02/2011 06:00AM
Do you wear your pet love on your sleeve?
And by that we mean, literally – is there pet hair on your sleeve? It's a small price to pay for having pets we adore, but stars like Ashley Greene, Taylor Swift and Mickey Rourke are inspiring us to show our animal love more creatively!
10 Things Your Cat Wants Right Now
Originally posted 06/01/2011 06:00AM
Your cat is a lot like Oprah Winfrey. A smart, sophisticated, larger-than-life personality who loves the finer things. June is Adopt-A-Cat month, and we've pulled together our favorite things for your fierce feline – from hysteria-inducing toys to sleek cat trees, these are items that your cat needs to live her best life.
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Originally posted 05/19/2011 07:45AM
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Kingston HyperX - Memory - 1 GB - DIMM 240-pin - DDR2 - 800 MHz / PC2-6400 - CL4 - 2 V - unbuffered - non-ECCItem#: YYKM-KHX6400D2LL/1G | Model#: KHX6400D2LL/1G
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Kingston HyperX memory - 1 GB - DIMM 240-pin Product Details
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Located within 2 miles (3 km) of Vineyard Farmers Market, Park Inn and Suites places you within a few miles (5 km) of Fresno Art Museum. This 201-room, 3-star hotel has an outdoor pool along with free in-room WiFi and free self parking. It's in central Fresno and also close to St. James' Anglican Cathedral and Fashion Fair Mall.
Start your day off with breakfast, available for a fee. Satisfy your hunger from the comfort of your room with room service.
Park Inn and Suites's 201 air-conditioned rooms provide refrigerators, coffee makers, and free local calls. Guests can expect free WiFi and 32-inch flat-screen TVs with cable channels. Bathrooms have hair dryers and free toiletries. Ironing boards are also included.
Property features
At Park Inn and Suites, guests enjoy an outdoor pool, a fitness center, and free WiFi in public areas. There's free parking, as well as a free airport shuttle (available 24 hours). The 24-hour front desk has staff standing by to help with dry cleaning or laundry, and answer any questions about the accommodations. This hotel also has conference space.
- Free WiFi in rooms and public areas
- Free parking
- Free airport shuttle
- Outdoor pool
Park Inn and Suites3737 N Blackstone Ave Fresno CA 93726
Hotel Amenities
Hotel Amenities
Park Inn and Suites features an outdoor pool and a fitness center. High-speed wireless Internet access is complimentary. Event facilities measuring 5000 square feet (465 square meters) include conference space. A roundtrip airport shuttle is complimentary to guests (available 24 hours). This Fresno hotel also offers dry cleaning/laundry services and room service (during limited hours). Onsite self parking is complimentary.
Park Inn and Suites has designated areas for smoking.
- 24-hour front desk
- Free airport transportation
- Total number of rooms - 201
- Breakfast available (surcharge)
- Conference space
- Dry cleaning/laundry service
- Fitness facilities
- Designated smoking areas
- Free WiFi
- Meeting rooms
- Conference space size (meters) - 465
- Free self parking
- Conference space size (feet) - 5000
- Outdoor pool
Family Friendly Amenities
- Outdoor pool
- Free Wi-Fi
- Refrigerator
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
- Premium TV channels
- Air conditioning
- Phone
- Free local calls
- Refrigerator
- Coffee/tea maker
- Free toiletries
- Hair dryer
- Iron/ironing board
- Cable TV service
- Flat-panel TV
- Free WiFi
- Room service (limited hours)
Where to Eat
Smugglers Restaurant - This restaurant specializes in American cuisine. Guests can enjoy drinks at the bar.
Room service (during limited hours) is available.
Nearby Things to Do
Recreational amenities at the hotel include an outdoor pool and a fitness center.
To make special requests for accessibility needs, please note them at check-out when you book your room.
Hotel Policies
Check-in time starts at 3:00 PM
Minimum check-in age is 18
Special check-in instructions:
Check-out time is noon
Payment types
- Pets allowed
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No rollaway/extra beds available
No cribs (infant beds) available


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The average salary of a(n) Police Officer in Columbia, Maryland is $66,122.
The average hourly rate of a(n) Police Officer in Columbia, Maryland is $31.79.
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Taken at Beresford Gap,Birchington,Kent,England.
Canon 7DCanon 70-200 f4L @159mmf131/500sISO 400Processed in Photoshop231 views 21/12/2012Featured in the group "Make an impression" (29/05/2012)
sea calm buoy blue horizon float yellow water boat
Beautiful array of blues Geoff, let alone calm, the colours just pop from the screen nicely.
Hi Stuart, many thanks for your appreciative comment :-)
Beautiful work dear Geoff.x
Many thanks Catherine :-)x
Such a beautifully balanced shot Geoff :)
Thanks Felicity :-)
Hi jammingene, many thanks for the feature and the banner :-)
Excellent! my friend… you created so beautiful artwork…I have speechless…………A 'No' uttered from the deepest conviction is better than a 'Yes' merely uttered to please, or worse, to avoid trouble.Mahatma Gandhi mentioned.………..Regards,SunnyBeautiful song; http://www.youtube.com/watch?v=Gro0_CTteOw&...
Many thanks for your lovely comment Sunny :-)
Beautiful work Geoff !
Cheers Tim.
Nicely done Sir…. the blues and yellows work very well.One click of the banner will take you to the group. Your work is welcome here and please enjoy it.
Thanks Derek :-)
May 17th, 2012► See your work in the Permanents Featured Gallery►Please participate in the ongoing Challenges Mary
Hi Mary, many thanks for the feature and the banner :-)
Many thanks for your lovely comment :-)
Thanks for the banner Rene :-)
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Posted at 4:30 AM on September 24, 2014
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|20 Reviews
|Property type
|Minimum Stay
|4 nights
Your booking will be backed by our Book with Confidence Guarantee when you complete your reservation online and finalise payment on HomeAway.Learn more
With panoramic views over the beautiful Puglian countryside, newly restored Trullo Isabella is the perfect location for a romantic holiday for honeymooners or two couples as its flexible sleeping can easily accommodate four people.
Although in a very rural peaceful location the trullo is between the two historic towns of Martina Franca, about 5km and fascinating Alberobello with its 1500 trulli clustered together, about 7km away.
The 300 year old trullo has been sympathetically restored to a very high standard. The main cone accommodates the living area which includes a fully equipped kitchen including a dishwasher, lounge area with sprung sofa bed and dining area with table and seating for four. A door leads onto the terrace.
In the smaller cone is the spacious bedroom which has a king size bed and ample storage. A door leads onto the terrace.
There is a shower room with toilet and wash hand basin which is accessible from both cones.
The property sits in two acres of grounds filled with wild flowers. This is surrounded by farmland dotted with trulli, many still not restored. There is a 5 meter pool overlooking the valley perfect for cooling off in the hot Italian summers, an excellent BBQ area with a outdoor gas burner. A dining table and chairs perfect for al fesco dining under a shady gazebo and sunbathing terrace with comfortable sun loungers and delightful rock garden all around. Trullo Isabella is the perfect place for relaxing and spending quality time with family and friends in a tranquil location.
The property is very well cared for by Chris & Alison who meet all guests on arrival in alberobello and accompany them to the property.
We had never been to Trullo Isabella in December so we decided to go over the New Year period and experience the firework spectacle on New Years Eve. What we hadn't accounted for was the snow. Overnight we had over two foot, which turned the landscape into a winter wonderland. Everything looked so beautiful and with the sun out and a cloudless blue sky we spent many hours outside, making a snowman, snow angels, walking the lanes and having snowball fights. The Prosecco was literally on ice, we stuck the bottle in the snow!
Back indoors we were cosy and spent the evenings watching DVDs, listening to music and reading our books. On New Years Eve we ventured outside onto the terrace and witnessed the three local towns pyrotechnics. The sky was illuminated and the snow on the ground enhanced the celebrations. It certainly lived up to its reputation.
The area hadn't seen this amount of snow for 27 years, normally if it does snow it's a couple of inches and gone within a day or two. The day we returned home, 3rd January, the temperature went up to 16 degrees and we were tempted to have a bbq.
We sincerely hope that our 2015 guests enjoy their stay at Isabella as much as we just have.
Spent a fantastic week here. Trullo Isabella is wonderfully appointed and has a lovely homely and cared for feeling. A perfect romantic getaway for couples! There are lovely towns and villages near by to explore, with great restaurants. That said, spending time relaxing at the trullo was just as good and the evenings were magical. A great holiday and we hope to return soon!
We had a great 5 days in this lovely Trullo.
The owners has made a great job. They transformed an old Trullo in a fantastic holiday home.
You have a great view and it' s very quit.
The last part of the road is a bit bumpy :)
We stayed in Trullo Isabella for a week. We had come to Puglia for a wedding with 6 friends, two of whom had the Trullo just up the hill from Isabella, and 4 had one a little walk down the hill. This worked incredibly well for all of us, and would be well worth thinking about if you wanted to go somewhere peaceful and charming with a group of friends or family.
Isabella is beautifully appointed, modernised to a very high standard, but still retaining it's undoubted charm. The inside is light and cool in the heat, or warm and cosy in the cold, with a very well-equipped kitchen, comfortable sitting area, lovely bedroom and small but modern bathroom. The inside and outside were spotless and the interior has a very home-from-home atmosphere with lovely personal touches, books, and games.
We were particularly impressed with the outside which is very spacious indeed. We barbecued for all our friends with PLENTY of room to spare! The area around the outside dining area is particularly attractive with well established plants everywhere. The lavender bushes are huge, interspersed with mint, oregano, oleander and a variety of other attractive plants and shrubs and the perfume in the early morning is divine, attracting a huge variety of butterflies. The fields and lanes around the Trullo are a mass of wild flowers and in the evening the nightingales sing from the adjacent Oak wood. The only sounds you will hear will be the singing of birds, the buzzing of bees and the odd tractor.
This was a perfect, incredibly relaxing break for us and we did little else but lie by the pool, (which has a lovely view,) read, go for walks and cook great local food. We had planned to do more sightseeing, but Isabella cast her spell and we saw no reason to leave.....
My wife and I are from the USA and stayed in the lovely countryside house for 5 nights. From the beginning of the reservation all the way to our departure everything was handled superbly by the owners and the agency. The house is located in a countryside setting about 15-20 minutes to the nearest town, so a car is a must. The house has been beautifully restored that has an incredible quaintness about it. In the mornings we would sit outside and have our morning coffee and watch the world go by. In the evening we would have our wine and munchies outside looking at the stars with only the noises of nature. The kitchen has all of the amenities that you could possibly need. The bedroom is plenty large enough with dressers for your clothes, and has a romantic feel to it. The bathroom has a shower that was big enough for my 225 lbs. there is a large living room with a couch and chairs as well as an eating table. There is a pool that we did not use, as the weather was only in the mid 60's.
WiFi is also available.
Overall I would certainly recommend the house to anyone that would love to spend a holiday in a countryside setting with a loved one. Or for that matter, a single person that just wants to get away from it all.
Thank you trullo Isabella for the most perfect honeymoon. Quite, secluded and romantic. Perfect! We couldn't have asked for a more romantic time. Maybe better weather, but the trullo is beautiful. Beautifully decorated, beautiful views and the bedroom is like a perfect little den that you step down into.
We had a great time exploring the local areas and tourist attractions.
We will be back!! And hopefully next time we'll be able to have a BBQ on the lovely looking clay oven type BBQ!
Thank you!!
Wow! What a fabulous find! We highly recommend a stay in this beautiful Trullo in a very peaceful, tranquil location. The Trullo has clearly been very lovingly restored and every need is catered for - with a lovely touch of welcoming bottles of wine and beer! Perfectly situated in the lovely Puglia region to visit many local sites, or just to visit the plethora of excellent restaurants - the food and wine in this region is fabulous and amazing Nablus when compared with Tuscany and Umbria. We will certainly return. So many thanks
|Rental Period
|Minimum Price
|Additional Nights
|Weekend Night
|Event Price
17 Sep 2016 - 30 Sep 2016
4 night minimum stay
for 4 nights
1 Oct 2016 - 16 Dec 2016
4 night minimum stay
for 4 nights
17 Dec 2016 - 30 Dec 2016
4 night minimum stay
for 4 nights
New Year
31 Dec 2016 - 6 Jan 2017
4 night minimum stay
for 4 nights
|No additional mandatory fees
|Refundable Damage Deposit
Our prices include all electricity, gas, water, full linen and towels, Wifi inside and out of the trullo. There is also a very efficient underfloor heating system at no extra cost for the cooler months.
We ask for either a non refundable £30 damage waiver or a refundable £300 breakage deposit payable with the balance.


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'I Love What I Do': A Portrait of a NYC Drummer
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This short documentary explores the life and work of "Amazen King" Solomon Roe, a musician who plays on subway platforms and city streets. "When I go home, it feels like I came from church," he says.
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The VW Camper Van Play Tent is a kid-sized version of the iconic 1965 Split Screen VW Camper Van. This play tent is made of a waterproof fabric with added UV protection, making it suitable for indoor and outdoor use. It has a flip-up entrance and mesh windows in the front. The tent easily pops open and folds up to be placed in the spare wheel carry bag for compact storage. It's available in light blue or baby pink. The play tent accommodates up to three children comfortably.
Most kids today probably don't know what a VW Camper Van is, but they'll still have fun pretending to go on road trips and whatever else they can imagine inside and outside with this easy-to-assemble play tent.
The VW Camper Van Play Tent is for ages 3 and up.
Adult assembly is required. It took us two minutes to get this set up. This structure uses a sprint steel loop that will spring open quickly. Caution must be used when handling this product. Folding the play tent back up is at least a two-person job. Children should never be allowed to fold or unfold the structure without adult supervision.
The VW Camper Van Play Tent is available to purchase at themonsterfactoryusa.com.
The Monster Factory also makes a larger VW Camper Van Tent for adults.
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1. Introduction
[2] Hydrologists are increasingly concerned with predicting the effects of global change on water scarcity, water quality, water-related natural hazards, and ecosystem service provision [Jackson et al., 2001; Wagener et al., 2010], as well as the potential feedbacks between land surface hydrology and the global climate system [Montanari et al., 2010; DeAngelis et al., 2010]. There are a number of features of catchment hydrology which continue to hamper predictability, including the tremendous heterogeneity in landscape properties and climatic inputs; the highly interconnected nature of hydrological response with climatic, ecological, geomorphological, pedological, and anthropological processes, all of which are subject to imposed change [Istanbulluoglu and Bras, 2005; Vitousek, 1994]; and the multiscale variability of resulting hydrological responses. Monitoring of hydrological responses occurs primarily at the whole catchment scale, where simplified lateral boundary conditions and flow aggregation through the river network facilitate water balance closure [Gupta and Dawdy, 1995]. However, detailed understanding of physical hydrological processes is often most applicable at point scales where environmental parameters may be approximated as homogeneous. Point-based predictions are notoriously difficult to relate to catchment responses [Blöschl and Sivapalan, 1995], leading to a gap between the scales at which processes occur and are understood and the scale at which observations are made and hydrological prediction is needed. The interconnectedness of catchment processes further complicates prediction because changes to any aspect of the system may propagate to others in complex ways, ultimately affecting the whole system's response. Therefore, predicting hydrological responses to global change poses a major challenge to hydrologists and Earth system scientists and requires a new generation of theories and descriptive principles. These principles must link local change to whole catchment response and must confront the challenges posed by the high dimensionality of the catchment system and the nonlinearity and complexity of relationships among its components [Dooge, 1986].
[3] Fortunately, the form and function of catchments result from long-term coevolution between water, soils, landforms, and ecosystems, and catchments consequently display a large degree of self-organization in hydrological and biophysical properties [Hopp et al., 2009; Wagener et al., 2004; Koster et al., 2000]. An attractive approach for simplifying the problem of hydrological prediction is to use this organizational structure to identify emergent properties or patterns that constrain relationships across processes and scales [Koster et al., 2000; Ducharne et al., 2000; McDonnell et al., 2007; Blöschl, 2006; Sivapalan, 2003]. Catchment hydrology has made great strides in prediction through utilizing two such emergent patterns: the geomorphological instantaneous unit hydrograph (GIUH) [Rodríguez-Iturbe and Valdes, 1979; Mesa and Mifflin, 1986], which uses the characteristics of the channel network to predict catchment storm response, and the topographic wetness index, which uses topographic features to characterize spatial patterns of soil wetness and forms the basis for many current models (e.g., TOPMODEL and RHESSys [Beven and Kirkby, 1979; Band et al., 1991, 1993]). Both cases draw on emergent relationships between geomorphological patterns and hydrological response. Using such emergent properties for "dimension reduction" [Holmes, 2005] simplifies prediction and helps to overcome some of the issues of heterogeneity [Blöschl and Sivapalan, 1995; Viney and Sivapalan, 2004]. More fundamentally, emergent properties are outcomes of the coevolution of catchment features and consequently offer a window into understanding the response of the entire catchment system to imposed change.
[4] The introduction of the GIUH and TOPMODEL, both in 1979, led to significant improvements in our ability to make hydrological predictions and advances in hydrological research. Both discoveries coincided with the wider availability of topographic information in the form of digital elevation models (DEMs). There is potential for other emergent patterns in catchment properties to be identified and used in a similar manner. In particular, the wide availability of high-resolution aerial photography, as well as advances in aerial and ground-based lidar [Lefsky et al., 2002], now offers unprecedented levels of information about the spatial distribution of vegetation in catchments. This paper is motivated by the prospect that spatial organization of vegetation might form the basis for a new set of emergent relationships to constrain hydrological processes at catchment scales. Linking vegetation distribution to hydrological function is attractive for several reasons.
[5] 1. Vegetation cover is a surface feature of catchments and as such is readily observable [Boggs, 2010]. Vegetation mapping suggests that vegetation cover and type in many catchments are influenced by patterns of water availability. These patterns may even persist in highly disturbed environments (see Figure 1). Thus, hydrological relationships inferred from vegetation patterns can be usefully applied across a wide array of sites and scales.
[6] 2. Vegetation is an important driver of evapotranspiration fluxes, which comprise 62% of terrestrial water balance [Shiklomanov, 1998], and often approach 100% of rainfall in arid climates [Budyko, 1974]. Removal or change in catchment vegetation, or even the diurnal variation of vegetation water use, is observed to alter the magnitude and temporal pattern of streamflow [Brown et al., 2005; Bond et al., 2002; Gribovszki et al., 2010]. Consequently, understanding vegetation water use and its scale dependence has the potential to explain a significant proportion of the water balance and its variability.
[7] 3. Furthermore, advances in ecohydrological science have progressed in pace with the availability of remote sensing vegetation data. Point-scale controls on water balance and soil moisture due to vegetation are increasingly well understood [Guswa et al., 2002; Rodríguez-Iturbe et al., 2007] and can be envisaged as driving the partitioning between vertical and horizontal water fluxes (or "green" and "blue" water) at a point [Falkenmark, 1997]. In the absence of spatial variation in precipitation inputs or soil hydraulic properties, spatial organization and scale dependence arise primarily due to spatial variation in the horizontal components of the flux, which, via either surface or subsurface redistribution, subsidizes downstream or downslope points with additional water to rainfall [Puigdefabregas et al., 1999; Yu et al., 2008; Valentin et al., 1999]. The lateral subsidy reflects and integrates upslope or upstream structures and processes, including connectivity, slope, convergence, and water balance partitioning. Although such subsidies are likely to be quite spatially variable, the probability that water balance is influenced by such subsidy processes should increase down gradient in catchments. Spatial structures in vegetation are known to naturally arise in response to water availability [Caylor et al., 2005; Scanlon et al., 2007; Rietkerk et al., 2004; Kéfi et al., 2007], at least in arid or semiarid environments. Because of the two-way coupling between the lateral subsidy (as a driver of moisture availability) and the presence of vegetation (as a driver of local partitioning), vegetation spatial organization is hypothesized to be both a control and a signature of hydrological processes. The link between vegetation pattern and hydrological process will vary in strength depending on the significance of other drivers of spatial variation in water balance (e.g., in soil hydraulic properties) and vegetation distribution (e.g., energy or nutrient availability, or disturbance regimes) within a particular watershed [Boisvenue and Running, 2006].
[8] 4. Finally, vegetation exhibits the potential for rapid, widespread change in response to changing environmental drivers [Jackson and Overpeck, 2000; Allen and Breshears, 1998; Clark, 1998; Clark et al., 1998; Barbier et al., 2006]. Consequently, vegetation patterns can also act as tractable indicators of system-wide change.
[9] The need for water balance predictions to be underpinned by improved understanding of the link between hydrological partitioning at point and catchment scales was a key finding of the 2009 Hydrologic Synthesis Summer Institute, as reflected in many of the papers presented in this special section of Water Resources Research (M. Sivapalan, Preface: Watersheds as hierarchical nonlinear space-time filters, manuscript in preparation, 2011). The papers included in this special section explore patterns in water balance at both whole catchment and point (or patch) scales, developing deeper insights into the controls and complexities of water balance prediction. The difficulties experienced in reconciling point level predictions with catchment-scale observations provide a strong motivation for addressing the scaling challenge in water balance partitioning, especially as they are influenced by vegetation.
[10] In this review paper we aim to combine advances in the quantification of catchment-scale water balance made during the summer institute with current understanding in catchment hydrology and ecohydrology. These ideas are synthesized in a network model which is used to test the plausibility of linking scale dependence in catchment water balance and catchment vegetation distributions, given a presumed two-way feedback between water and vegetation. The model immediately highlights a number of relationships between climate, topography, and vegetation within catchments. We focus on these as the drivers of scale-dependent behavior in ecohydrology and outline a set of broad research opportunities and challenges in catchment ecohydrology.


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For general Town information contact:
Deborah C. Waldron, Town Clerk, at
859 State Route 326
Cayuga, NY 13034
Phone: (315) 889-7717
Fax: (315) 889-5109
Email: firstname.lastname@example.com
From route 90 (NYS Thruway), take exit 40 (Weedsport). Turn right onto route 34 South to the City of Auburn. In Auburn, turn right onto Route 5 and 20 West. Take 5 & 20 to Route 326. Turn left onto Route 326 and proceed to the Town Hall located on the right hand side of the road.
PowerPoint presentation regarding the flowchart for building applications is available here. Presented at the March 9, 2015 meeting.
Water Quality Report - District 1
Water Quality Report - District 2
2016 Tentative Assessment Roll
Leak Detection Report - Water District 2, July 2015
State Comptroller's Audit Report
My first 2 and 1/2 years as your legislative representative, and recently as Chair of the County Legislature, have been busy and rewarding. I am pleased that I could help a number of Scipio residents resolve County concerns, and I encourage anyone who has an issue in the future to let me know. I cannot promise to resolve the issue, but I can promise to do all I can on your behalf.
The County's budget is a challenge, and I am working with other members of the Legislature to move toward a budget that is balanced and that continues to support the services which we all expect from the County as well as the services that we are mandated by the State to provide. Most importantly, I want to support a budget that reflects your thoughts and needs.
To get a better idea of your priorities as well as your concerns, complaints and kudos, I am holding a series of public hall meetings to discuss the budget, county services, issues of concern and any other topics you might wish to bring up.
The sessions are as follow and you should feel free to attend any one (or more) that are convenient,whether in Scipio or another location.
Aurora: Wednesday, Oct. 19 at 6 PM
Scipio: Thursday Oct 20 at 6 PM
Ledyard: Saturday Oct 22 at 11 AM
Springport: Tuesday Nov 1 at 1 PM
Union Springs: Monday, Nov 21 at 11 AM
Thanks for your support and let me hear from you if you have any suggestions, concerns or questions
Keith Batman, ChairCayuga County LegislatureDistrict 7 Representative Scipio, Ledyard, Springport


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Department of inter-religious studies
st. xavier's college, mumbai
Inter-Religious Laughter - A Joke?
Panel Discussion on Communal Harmony
On Tuesday, 2nd August 2016, the Dept. of Inter-Religious Studies (DIRS) and the AICUF organized a Panel Discussion on the same theme that was taken for the College Day Mass held on 30th July: "To Be Religious Is To Be Inter-Religious." The panelists were professors from different faculties and different religious traditions too: Gulshan Shaikh (Science), Radhika Rani (Arts), Periyanayagi Subramaniam (BMM), and Awanish Kumar (Public Policy/BMS). The panel was skilfully chaired by Rector Fr. Tony J D'Souza.
Read what our team member Amruta says about the panel discussion on our blog.
After a brief video clip indicating the shocking violent communal mentality, the panelists briefly spoke about the meaning of religion in their personal lives and about their stand at a time when religious conflicts are on the rise. They also shared views on corporate terrorism and its impact on different communities. The questions posed by students after the session led to a stimulating discussion on atheistic movements, religious terrorism, commercialization of ritualistic festivals and the purpose of religion in our individual and collective lives. The session ended with the Pope's statement on the recent brutal killing of a priest in France that demonstrated the challenging path to healing and forgiveness. The keen interest of students in the over-packed classroom is a positive sign of hope for communal harmony.
Launching Honours Courses
We are excited to launch the DIRS Honours Courses this year.
The courses will provide an understanding of various religions as well as deeper insight into our role as cosmic beings.
For details/To register: Visit the DIRS Office, First Quad, 10.30 am-1 pm.
We are a department based in St. Xavier's College, Fort, Mumbai. We are passionate about issues related to communal harmony, social justice, ecology and spiritual well-being.
Recent Events
DIRS collaborated with the amazing team at AICUF-Xavier's to organize an InterFaith Prayer Service for students and staff on 7 June at the beginning of the academic year.
In these times of disparity and dissent, this service aims to build a greater appreciation for different faiths at the Xavier's campus.
Co-Creating Cosmic Compassion
For Christmas of 2015, we at the DIRS decided to make an unconventional crib--one that protects the earth, challenges traditional views, and celebrates all creation.
Visitors put up stars to represent their connection to the universe. Isn't it amazing that the atoms in our body are similar to the atoms in the stars?
The idea behind the Cosmic Crib was to address the growing need for compassion towards all cosmic beings: humans, animals, plants, the earth.
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for a fed ex delivery? Proud of myself for signing for my ds's sneakers...hair saturated with dye, drips on my face..yeah very attractive
If you were in the middle of a home hair dye job would you answer the door
Ds14, ds13, ds11, dd10, ds8, dd7
Comments (10)
do you need some ice for that? i can lend you my soul *lukesdiner
My Independent Toddler, 10/'12
""Normal pregnant" as opposed to...slut muffin pregnant?" -SafelyInDanger
I've picked DD up from school with my hair up in foil doing purple streaks mid-dye job, so yeah, I'd open for FedEx. But FedEx ding dong ditches here, so I wouldn't have to sign anything. They insist they have authorization to leave packages that require a signature without, even though we've never given it and have called and told them to stop leaving things that require a signature on the front porch.
Wino's favorite bitch and one of truemama's too. Robin to TACs batman.
Pardon my cuticles.
One time I had just finished taking a shower and the Fed Ex guy was knocking and it was the second attempt.
I put on my jeans without underwear and ran to open the door. He looked at me weird while giving me the packet.
When he left I went up to my room to finished changing I realized I forgot to zip upmy jeans and had no underwear on! 😳😳😳
"PUT THE BUNNY BACK!" - 99.8% of the BHB
Just call me Pepper. Dr is so formal.


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The Well is a United Methodist community of grace, experiencing God's love together through worship, study, fellowship, and service.
We are still in the process of repairing our building after the recent flooding. During the month of September, please join us for worship at FUMC Ponchatoula, 201 E. Pine Street. The Well's service at FUMC takes place every Sunday at 11:15 am.
If you would like to see how you can help with flood relief, please email Rev. Warren Clifton at firstname.lastname@example.com.


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Novel amphiphilic fullerene[70] derivatives that are rationally designed to intercalate in lipid bilayers are reported, as well as its vesicular formulation with surprisingly high loading capacity up to 65% by weight. The amphiphilic C70 bisadduct forms uniform and dimensionally stable liposomes with auxiliary natural phospholipids as demonstrated by buoyant density test, particle size distribution and 31P NMR. The antioxidant property of fullerenes is retained in the bipolarly functionalized C70 derivative, Amphiphilic Liposomal Malonylfullerene[70] (ALM) as well as in its liposomal formulations, as shown by both electron paramagnetic resonance (EPR) studies and in vitro reactive oxygen species (ROS) inhibition experiments. The liposomally formulated ALM efficiently quenched hydroxyl radicals and superoxide radicals. In addition, the fullerene liposome inhibited radical-induced lipid peroxidation and maintained the integrity of the lipid bilayer structure. This new class of liposomally formulated, amphipathic fullerene compounds represents a novel drug delivery system for fullerenes and provides a promising pathway to treat oxidative stress-related diseases.
Fullerenes and their derivatives have been proposed as free radical scavengers (1), and a number of investigations have studied fullerene (C60) derivatives as potential free radical antioxidant therapeutics (2–5). Fullerenes (both pristine and derivatized fullerenes) have a tendency toward aggregation in aqueous environments making them unsuitable for therapeutic applications. For example, formulation techniques for preparing fullerene-based therapeutic candidates include host-guest complexation with cyclodextrins and calixerenes, surfactant solubilization with Tween-20 and polyvinylpyrrolidone (PVP), etc. These preparations have their respective limitations in terms of uniformity of formulation, loading capacity, aggregation and partition coefficient (5). Derivatization of fullerenes by directly adding moieties to the carbon cage has been used as a strategy to produce useful drug candidates. Such fullerene compounds including polyhydroxylated C60 (fullerenol) (6–7), polysulfonated C60 (8), carboxylated fullerenes (9–10) have been shown to block free radical damages in several oxidative stress-related diseases including ischemia/reperfusion injury, inflammatory apoptosis, and neurogenerative diseases. However, aggregation in aqueous media to form particles with a broad range of diameter distributions is a general problem for many of those compounds (11). Poly-derivatized fullerenes are often a mixture of many compounds, poorly characterized and not suitable for pharmaceutical development. In addition, it has been shown that cytotoxicity of fullerenes is related to the degree of cage derivatization, water solubility, aggregation and particle size (11). An alternative approach in which fullerenes are encapsulated in bilayer vesicles such as liposomes has been proposed to overcome these limitations. Bensasson described the preparation of vesicles by incorporating C60 into L-α-phophatidyl cxholine purified from egg yolk (Egg-PC) (12). However, the authors reported that only 3% or less C60 was incorporated in Egg-PC liposomes and the preparation was not uniformly reproducible. Incorporation of C60 into L-α-phophatidyl ethanolamine (PE) was limited to 7% (13). Fullerene liposomes have also been prepared by transferring fullerenes from their water soluble host-guest complexes (C60·γ-CD and C70·γ-CD) to lipid membranes for photodynamic therapy (PDT) (14–15). The limited number of reports on liposomal fullerene formulations was all intended to use underivatized fullerenes that are not lipophilic, rather aromatic, and structurally incompatible with natural phospholipids, therefore the fullerene contents were low and their dimensional stabilities were problematic. Further, the loading capacity of lipophilic drugs physically entrapped in liposome bilayer is limited due to the membrane destabilization effect. Thus, it is necessary to develop new drug delivery strategies that can efficiently deliver fullerenes for therapeutic applications.
Given the low contents of pristine fullerenes in liposomal formulations, we hypothesized that incorporating amphiphilic fullerenes in vesicles would greatly increase their ability to be intercalated within the lipid bilayers. Herein, we report the design and synthesis of this new class of amphiphilic fullerenes, their liposome formulation and biological activities as radical scavengers. A key to obtaining a uniform vesicular preparation with high fullerene content and dimensional stability is to incorporate amphiphilic fullerene derivatives which mimic the structure of natural phospholipids. Hirsch has reported amphiphilic C60 derivatives in which multiple aliphatic hydrocarbons were attached at various sites on the fullerene cage (16–17). However these "buckysomes" don't assemble into stable bilayers readily and the addition of multiple groups could significantly damage its bioactivities.
Figure 1 illustrates the design strategy in which the amphiphilic fullerenes and phospholipids are hypothesized to coassemble and form bilayer vesicles. As shown below, this method leads to highly increased loading capacity of fullerenes. The amphiphilic fullerene compounds don't form bilayer vesicles by themselves, but require membrane-forming lipids with lipid-to-fullerene molar ratio greater than 1:1 in order to produce uniform and dimensionally stable vesicles. We have also discovered that the oval structure of C70 molecule (as opposed to the spherical C60) provides a novel structural platform to prepare this new type of amphiphilic fullerenes. C70 has two reactive poles and a relatively inert equatorial region and this allows for sequentially attaching lipophilic and hydrophilic groups at the two poles, respectively (18). The large underivatized zone around the C70 belt has very high radical reactivity due to the significant orbital overlap of its lowest unoccupied molecular orbital (LUMO) and highest occupied molecular orbital (HOMO) that is expected for sites of maximum ). radical reactivity (19–21 The fullerene-enriched liposome provides a novel formulation approach that not only enhances the fullerene delivery efficiency but also maintain their antioxidative properties.
To a stirred solution of C70 (84.0 mg, 0.1 mmol), didodeceylmalonate 1 (44.0 mg, 0.1 mmol) prepared using literature procedure (22), and iodine (25.4 mg, 0.1 mmol) in 60 mL of dry toluene was added dropwise a solution of DBU (38.0 mg, 0.25 mmol) in 5 mL of dry toluene under nitrogen at room temperature. Upon completion of addition, the reaction mixture was stirred for additional 3 hours. The reaction mixture was then washed with brine and dried over anhydrous MgSO4. The raw mixture was subjected to flash chromatography on silica gel. Unreacted C70 was removed by eluting the column with a mixture of toluene and hexanes (60/40, v/v), and then the eluant was changed to toluene/hexanes (90/10, v/v) to give the product 2 (108 mg, 85%). The undesirable bisadducts were eluted from the column with DCM. MALDI-MS: 1278.4, 1H NMR (CDCl3): δ 0.79 (6H, t), 1.20 (32H, m), 1.38 (4H, m), 1.75 (4H, m), 4.37 (4H, t); 13C NMR (CDCl3) δ 14.5, 22.3, 25.8, 28.7, 29.1, 29.2, 29.3, 29.8 (3×), 31.9, 37.2, 67.0, 130.7, 130.8, 130.9, 132.8, 133.6, 137.0, 140.7, 141.6, 142.2, 142.8, 143.0, 143.5, 143.8, 143.9, 144.9, 145.9, 146.0, 146.5, 147.0, 147.3, 147.5, 147.6, 148.4, 148.5, 148.6, 148.8, 149.1, 149.3, 149.4, 150.6, 150.8, 151.2, 151.3, 151.4, 155.1, 163.5.
To a stirred solution of malonic acid (1.04 g, 10 mmol) in 60 mL 1,4-dioxane was added 2.78 mL of TEA (2.02 g, 20 mmol). The mixture was stirred for 15 minutes before tert-butyl bromoacetate (4.68 g, 24 mmol) was added dropwise. The resulting mixture was vigorously stirred for 2–3 days until the reaction was complete as monitored by TLC. The precipitates were then filtered and the filtrate was washed twice with brine, dried over MgSO4, rotavaped in vacuo to give the pure di(tert-butylglycolate)malonate 3 as a colorless oil (2.92 g, 88%). 1H NMR (CDCl3): δ ppm 1.39 (18H, s), 3.51 (2H, s), 4.49 (4H, s); 13C NMR (CDCl3) δ ppm 28.5, 40.2, 61.4, 82.3, 165.5, 167.3.
To a stirred solution of monoadduct 2 (127.8 mg, 0.1 mmol), di(tert-butylglycolate)malonate 3 (33.2 mg, 0.1 mmol), and iodine (25.4 mg, 0.1 mmol) in 60 mL of dry toluene was dropwise added a solution of DBU (35.0 mg, 0.22 mmol) in 5 mL of dry toluene under nitrogen at room temperature. The resulting reaction mixture was stirred for 6 hours. The reaction mixture was washed with brine and then dried over anhydrous MgSO4. The raw mixture was subjected to flash chromatography on silica gel. Unreacted monoadduct was removed by eluting the column with toluene, and then the eluant was changed to DCM to give the product (121 mg, 75%). MALDI-MS: 1608.2, 1H NMR (CDCl3): δ 0.75 (6H, m), 1.19 (32H, m), 1.38 (4H, m), 1.43 (18H, s), 1.71 (4H, m), 4.39 (4H, m), 4.75 (4H, m). The product diester (80.0 mg) was dissolved in a mixture of 30 mL DCM and 9 mL TFA, and stirred for 2 hours. The solvent was evaporated and dried under vacuum to quantitatively yield pure ALM. MALDI-MS: 1498.2 (see MALDI-MS spectra in SI), 1H NMR (DMSO): δ 0.79 (6H, m), 1.21 (32H, m), 1.39 (4H, m), 1.74 (4H, m), 4.40 (4H, m), 4.78 (4H, m).
Two parts (by weight) of egg-PC or other lipids such as DMPC and DSPC were added to one part amphipathic ALM in diethyl ether (1mg/mL). The addition of lipids enhanced the solubility of ALM, although ALM itself has reasonable solubility in diethyl ether. The mixture was sonicated for 2 minutes before filtered via 0.2 μm filter. To the filtrate an aqueous buffered solution (PBS, phosphate buffered saline, pH = 7.4) was added, and the two phase mixture was sonicated in a bath sonicator while purging with nitrogen to produce oligolamellar vesicles. Those oligolamellar vesicles were extruded with nucleopore membranes of 0.4 μm, 0.2 μm and 0.1 μm, twice each pore size. The final ALM concentration in liposome suspensions was determined by UV-Vis spectroscopy with a standard curve after extracting it to organic solvents. Size distribution of extruded liposomes was measured by dynamic light scattering (DLS) with Zetasizer nano S90.
Dye-encapsulated liposomes were prepared by adding a buffered solution of the dye HPTS (20 mM, pH = 6.6) to an ether solution of egg-PC lipids (1 mg/mL) with or without ALM (1% by weight), purging nitrogen to remove ether in a bath ultrasonicator at room temperature, and extruding the crude liposomes with 400, 200 and 100 nm nuclear-pore membranes twice each. Dye-encapsulated liposome materials were separated from free dyes by SEC (size exclusion chromatography) on a Sephadex G-50 column with a buffered solution (pH = 7.8) (23–24). The final dye concentration was 0.2 mM as determined by its UV-Vis absorption. The absorption spectrum of the purified dye-encapsulated liposome samples were taken before and after the addition of Fenton reagents, and the final concentrations of H2O2 and FeSO4 are 1 mM and 0.05 mM, respectively. Each scan was recorded at 30 min, 1 hr, 2 hr, 4 hr, 8 hr, 16 hr, 24hr, 32 hr and 48 hr after the radical initiation. The absorbance ratio (A450nm/A405nm) and absorbance difference (A450nm-A405nm) were plotted as the function of reaction time.
EPR studies on radical quenching (hydroxyl radicals and superoxide radicals) were performed as described (25). Compound ALM was dissolved in dry DMSO at 1.0 mg/mL (0.67mM) and DMSO was run as a vesicle control. Hydroxyl radicals were generated using standard concentrations of Fe2+/H2O2 through Fenton reactions. Superoxide radical anions O2·− were generated through xanthine oxidase metabolism of hypoxanthine (HX/XO). EPR signals were acquired after 20 minutes incubation of ALM with radical-generating systems.
U937 monocyte cells obtained from ATCC (Manassas, VA) were cultured in RPMI-1640 media supplemented with 10% FBS (fetal bovine serum). Cells were pretreated with ALM liposome, control liposome or untreated overnight in a 37°C incubator with 6% CO2, washed, and resuspended in RPMI medium containing 5 μM DCFH-DA (2',7'-dichlorodihydrofluorescein diacetate) at 37°C for 30 minutes. After incubation the cells were washed (to remove any excess DCFH-DA) and activated with 10 μg/ml LPS (lipopolysaccharide). Activation-induced changes in mean fluorescence were measured real time using a Perkin Elmer LS55 Spectrofluorometer with excitation at 502 nm and emission at 523 nm for 15 minutes. The data are presented as fluorescence intensity of the 523 nm emission over time. All experiments were performed in triplicate. The ROS inhibition was defined as the percentage of the loss of DCF fluorescence when treated with liposome samples relative to the fluorescence intensity of untreated ones. Separate experiments were performed to ensure that the liposomal fullerenes do not interfere with the indicator dye in terms of the intensity of fluorescent signals.
Scheme 1 shows the synthesis of amphiphilic C70 compound ALM. The hydrophilic and hydrophobic groups are introduced to C70 through two-step cyclopropanation reactions of respective malonates under typical Bingel-Hirsch conditions in high yield (26–27). Di(tert-butylglycolate)malonate 3 was prepared from malonic acid and tert-butylbromoacetate in the presence of TEA (triethylamine) in 1,4-dioxane at room temperature for 2–3 days. After solvents were evaporated, two phase extraction (water and chloroform) yielded pure compound 3 in 85% yield. C70 monoadduct 2 was synthesized in 80% yield by reacting C70 and didodecylmalonate 1, and purified with silica gel column. Compound 2 then underwent the second cyclopropanation reaction with malonate 3 to produce the protected precursor of ALM, which was subsequently treated with 30% TFA (trifluoroacetic acid) in DCM to deprotect the tert-butyl esters and produce the amphiphilic compound ALM (22). Both ALM and its tert-butyl ester precursor were fully characterized by NMR, MALDI-MS, FT-IR and UV-Vis absorption spectroscopy. In addition, we have demonstrated that the three regioisomers of the C70 bisadduct ALM could be separated by reverse phase HPLC (0.1% TFA in ethanol, C6-phenyl column, Supporting Information Figure S1), and the structure of each of the three peaks in the HPLC chromatogram was assigned based on their polarity and distinct UV-Vis absorption in the range of 350–600 nm (18). This general synthetic approach can be used to prepare a variety of amphiphilic C70 compounds, simply by replacing its glycolic acid residues with other polar groups.
ALM was first formulated in liposomes with egg-PC (L-α-phosphatidylcholine) by the reverse phase method, and the resulting suspension was extruded to obtain small vesicles (28–29). 31P NMR spectroscopy confirmed the formation of bilayer liposomes and 31P spectrum of ALM-PC liposome (1mg/mL ALM) shows a very sharp signal at 2.55 ppm, with a half line-width of 2.8 Hz, which is comparable to the corresponding values of liposomes made of only egg-PC (Supporting Information Figure S2) (30). The particle sizes of extruded (with 0.1 μm polycarbonate nucleopore membrane) liposomes were confirmed by DLS with an average diameter of 100 ± 20nm (31). Intriguingly, the fullerene liposomes were dimensionally very stable. The amphipathic fullerene didn't separate from the phospholipids during and after nucleopore extrusion. This was confirmed by buoyant density separation test under conditions (high-speed centrifugation at 18,000 G for 30 min.) where fullerenes not stably incorporated in bilayer membranes would separate from lipid vesicles and precipitate to the bottom of the 40% sucrose cushion. All fullerenes were found to stay on the top of sucrose solution after centrifugation, indicating that they remained tightly associated with lipids (Supporting Information Figure S3). The tight association between ALM and PC lipids was further confirmed by the observed co-elution of ALM and egg-PC on a size exclusion column. The fact that ALM only didn't form liposome and it needs the assistance of regular lipids to coassemble into liposomes also demonstrates the successful incorporation of ALM molecule in the bilayer structure formed by the auxiliary lipids (Supporting Information Figure S4). In fact, the ALM-liposome is stable for at least one year without noticeable precipitation or aggregation. The chemical stability of the fullerene compound in liposome formulations was also monitored by MALDI-MS, UV-Vis and HPLC after extracting fullerenes into organic solvents from aliquots of liposome samples, showing no decomposition or other structural changes. Next, we examined the ratio of fullerenes to lipids in the course of forming stable liposome, and found that fullerene-to-lipid molar ratio could be as high as 1:1 (or mass ratio of roughly 2:1 or 65% fullerenes). In typical preparations, the fullerene concentration is 1.0 mg/mL liposome in phosphate buffered saline. ALM was also demonstrated to form liposomes in a similar fashion with other lipids such as 1,2-dimyristoyl-sn-glycero-3-phosphocholine) (DMPC) and (1,2-distearoyl-sn-glycero-3-phosphocholine) (DSPC).
Electron paramagnetic resonance (EPR) studies were conducted as described by Ali et al (25) to confirm that bipolarly functionalized C70 compounds were still capable of efficiently scavenging oxygen radicals (hydroxyl and superoxide radicals). Representative EPR spectra (Figure 2, insert) show typical HO· signals, as well as their quenching by ALM at four different concentrations. Figure 2 also shows the dose-response curve of hydroxyl radical-quenching by ALM solution in DMSO. As expected, ALM is a highly potent scavenger for hydroxyl radicals, significantly reducing HO· four folds at 10μg/mL (6.7uM). ALM also effectively quenched superoxide radicals at a slightly lesser extent. It is noteworthy to point out that ALM, due to its amphipathic nature, forms micelles in the assay media, and its antioxidative efficacy might be partially masked due to its limited access and interaction with free radicals generated in the media.
When lipid molecules, especially unsaturated lipids in cell membrane, are exposed to radicals such as hydroxyl radicals, highly reactive lipid species (lipid alkyl radicals and lipid peroxy radicals) are formed and the resulting lipid peroxidation can eventually cause membrane leakage and cellular dysfunction (32). Fullerenes formulated in liposome vesicles are particularly attractive for inhibiting lipid peroxidation. The protection effects of ALM liposome on hydroxyl radical-induced lipid peroxidation were therefore evaluated. The hydroxyl radicals were generated by the Fenton reaction as described above. A pH sensitive dye 8-hydroxylpyrene-1,3,6-trisulfonic acid trisodium salt (HPTS) was encapsulated in the internal aqueous compartment of ALM-liposome and control liposome with a lower pH of 6.6 (23–24). The outer bulk aqueous phase has a higher pH of 7.9. Upon membrane leakage caused by lipid peroxidation, the dye absorption ratio A455nm/A405nm increases due to the rising pH, and a higher ratio A455nm/A405nm indicates a greater extent of membrane leakage and lipid peroxidation. Fullerenes have strong absorption in the range of 400–450 nm, thus the ALM content was kept very low at 1% to clearly monitor the spectral changes of the dye. In order to explicitly demonstrate the protection effects, both absorbance ratio (A455nm/A405nm) and absorbance difference (A455nm-A405nm) were plotted as a function of time (t = 0 when HO· generation reaction was initiated) (Figure 3). The membrane leakage in the control liposome was dramatic, but it was minimal in the ALM-liposome sample. Additional control experiments were also conducted and the A455nm/A405nm of HPTS was monitored in ALM-liposome or control liposome samples in the absence of the Fenton reagents. No noticeable changes in the absorption spectra of HPTS were observed for both control samples, excluding the possibility that the control liposome is inherently leakier than the ALM-encapsulated liposome. These results clearly demonstrate the strong protection effects of ALM liposome against radical-induced peroxidation and membrane leakage.
ALM liposome was also evaluated for its capability to quench extra cellular reactive oxygen species (ROS) release triggered by lipopolysaccharide (LPS) (33–34). The monocyte cell line U937 used in this study is clinically relevant to atherosclerosis. The generation of foam cells from activated monocytes involves ROS overproduction and is a key inflammatory process in atherosclerotic plaque buildup (35). U937 monocytes, before LPS activation were treated with a cell-permeable fluorogenic probe 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA) (36). Following LPS activation, DCFH-DA underwent cellular hydrolysis and oxidation by ROS to generate the highly fluorescent 2',7'-dichlorofluorescein (DCF). As shown in Figure 4, ALM liposome inhibited cellular ROS release while the control liposome (without ALM) did not. More than 80% ROS release was inhibited when the cells were treated with 6 μM ALM liposome samples, and even at 6 nM, the inhibition was over 20%. This suggests that the liposome formulation efficiently delivered amphiphilic fullerenes into cells and effectively exerted its anti-ROS efficacy. The liposomal ALM was also compared with a well-studied water soluble C60 derivative-C3 (six carboxyl groups – three malonic acids directly attached to a C60 cage) in this assay (9). As shown in Figure 4, ALM was 40–70% more potent than C3 in scavenging cellular ROS when compared at equal molar concentrations. This could be explained by the difference in their dipole moments, structural dimension and the resultant ability to intercalate in lipid bilayer and permeate cell membranes. Amphiphilic fullerene ALM has higher lipid/aqueous partition coefficient than C3 in favor of membrane permeation in addition to the potential endocytotic uptake of ALM liposome.
Finally, the cytotoxicity of the ALM liposome was examined. A number of factors including chemical structure, surface modification, water solubility, aggregation, particle size and preparation procedures appear to have impacts on fullerene toxicities and behaviors in biological systems (11, 37). In general, well characterized fullerene derivatives with high solubility in buffer have little or no toxicities. We evaluated the cytotoxicity of ALM liposome with U937 monocytes, and ALM was found not cytotoxic to U937 cells when incubated with up to 67 μM (0.1mg/mL) of ALM for 6 days. The cell viabilities were comparable for ALM-treated, vitamin E-treated and untreated cells at all concentrations (Supporting Information Figure S5).
We have presented a novel fullerene delivery approach via liposomes enriched with amphiphilic C70 bisadducts that were designed to structurally mimic cellular membrane lipids. The choice of C70 along with its inherent bipolar bisaddition pattern represents a novel pathway to design amphiphilic fullerene compounds compatible for vesicular incorporation. The strong association between reported fullerenes and auxiliary lipids allow them to form dimensionally stable liposomes with as high as up to 65% (by weight) fullerene. By mimicking the structure of naturally occurring lipid molecules, this design overcomes several limitations in previously reported formulations including 1) low fullerene content of 3%–7% due to their use of underivatized C60 (12–13) or lipophilically functionalized C60 (38), structures of which are not dimensionally compatible with the polar head/lipophilic double-tail structure of lipids; and 2) damaged antioxidative bioactivity due to the multiple additions of six groups to C60 in an octahedral pattern where the spherical pi-electron conjugation is interrupted leading to interconnected biphenyls (16, 39). As a drug delivery vehicle, the high fullerene loading capacity is very important and it is advantageous especially for in vivo studies such as the delivery of fullerene to its intended region of action at sufficient concentrations with lower dose volumes. The vesicularly-formulated fullerene ALM has been demonstrated as potent radical scavengers in three separate ROS-related experiment settings. In summary, this present approach provides a new way to deliver fullerenes to sites where their antioxidant properties can be exploited and provides a platform for synthesizing new fullerene-based therapeutics that not only retain their biological activity but can be delivered via liposome carriers.
This work was partially supported by NIH Grants 1R01GM083274-01 and 1R43HL087578-01A1 (CLK). We thank Dr. Anthony Ribeiro at Duke NMR Center for assistance in acquiring the 31P NMR spectrum.
SUPPORTING INFORMATION AVAILABLE: Additional information as described in the text and mass spectra. This material is available free of charge via the Internet http://www.acs.org.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text: Here is an audio demo of the new LB303 Synth. This demo is rather corny, but you can hear the potential of the TB303-es-que bass synth. I need to finish the user interface and allow the automation to be interpreted between notes (right now only the cutoff and resonance have knobs, and they are only read at the beginning of each note)Slide and Accent are still not featured. I plan on releasing it without those two features for the time being (in hopes someone would be interested in implementing them :D )The demo: http://einstein.etsu.edu/~llama/lb303demo.oggEnjoy.


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Recent Meetups
August 20 · 7:30 PMHarmonic Translations: Overtone Concert, Workshop and Live Synesthesia Painting
Harmonic Introductions and Connor Boyd Synesthesia Paintings are excited to present another collaborative Harmonic Translations event! Saturday, August 20th, 2015 | 7:30... Learn more
August 7 · 2:00 PMSunday Afternoon Overtone Concert
Join Harmonic Introductions on Sunday, August 7th as they perform as part of the Glenview Mansion's 'Sunday Afternoon Concerts' series! Harmonic Introductions is a... Learn more
July 31 · 3:00 PMHarmonic Hike - Loch Raven Reservoir
Harmonic Hikes are great opportunities for people of all ages and musical backgrounds to learn about overtone singing out in nature. On Sunday, July 31st, directors Robb... Learn more
June 11 · 11:00 AM6/11~ Harmonic Hike at Great Falls Park
Hello enCHANTers and enCHANTresses! Harmonic Hikes are great opportunities for people of all ages and musical backgrounds to learn about overtone singing out in nature.... Learn more
January 16 · 7:30 PM16th-Overtone Singing Concert: Music for a Winter's Eve @ Christ the Servant
Join Harmonic Introductions as we put on a wonderful concert, at Christ the Servant Lutheran, of original music in this unique style of vocalization! We will offer... Learn more
- See all past Meetups


text:
by Rose Grant
Everyone has a favorite street food, whether it's a genuine Philadelphia cheese steak, a tart Italian ice spilling over the edges of a paper cup or a jumbo frank slathered in mustard. Rarely has the diversity of such colorful comestibles been as appreciated as in this lively collection of recipes. According to Grant, street food not only "taps into our nostalgia for the past, for holidays and fairs," it is also the most visible evidence of the American melting pot, or wok or grill. Fine, but don't expect complete meal ideas. There are more than 100 offerings, as varied as an ethnic-food festival, grouped by how a food is eaten. For example, succulent Satay Ajam (Indonesian skewered chicken with a peanut butter sauce) is under the heading "Food on a Stick," and the section on "Sandwiches" ranges from Texas chili dogs to Trinidad shrimp curry rôtis. Crêpes de Bretagne, made from buckwheat pancake mix, nutmeg and Grand Marnier, is listed under "Sweets," as are jelly apples. Street Food also introduces Indian snacks like spicy potato samosas (a kind of dumpling), Bolivian empanadas de queso (deep-fried cheese turnovers) and Japanese noodle salad. Of course, none of these treats can replace the bustle of an outdoor event—but anyone who eats enough of this food will quickly grow into a crowd. (Crossing Press, $16.95)
Picks and Pans Review: Street Food
updated 10/24/1988 AT 01:00 AM EDT
•originally published 10/24/1988 AT 01:00 AM EDT


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Texas architecture firm AlterStudio has turned an Austin bungalow into a three-bedroom home with a black timber extension connected by a glass corridor (+ slideshow). More »
Tag: renovations
Sarah Wigglesworth adds new metal skin to London factory containing artists' studios
OMA creates a light-filled New York studio for artist Cai Guo-Qiang
OMA unveils major renovation plans for Berlin's KaDeWe department store
Rem Koolhaas' firm has revealed plans to overhaul continental Europe's largest department store, with the addition of a glass rooftop extension and a series of sculptural new staircases (+ slideshow). More »
McLaren Excell creates "floating" loft room inside renovated schoolhouse home
Arrokabe Arquitectos creates all-new interior for 18th-century Spanish house
Behind the traditional facade of this Spanish townhouse, Arrokabe Arquitectos has created a contemporary interior featuring a wave-shaped ceiling, a floating staircase and an attic music room. More »
Mae Architects gives second life to unloved Hillington Square housing estate
Demolition isn't the only solution to the problem of the UK's troubled housing estates according to architect Alex Ely, whose firm Mae Architects is renovating a series of 1960s slab blocks in Norfolk (+ slideshow). More »
Buddhist temple in Tokyo upgraded by Satoru Hirota Architects
Satoru Hirota Architects has overhauled the site of a Buddhist shrine dating back to Japan's Edo period, adding a triangular reception hall and a priest's quarters with bare concrete walls (+ slideshow). More »
Studio apartment in Paris by Anne Rolland Architecte has a hidden converted slurry pit
B-ILD combines two apartments in Brussels to create live-work penthouse
Nook Architects uses mesh to divide open-plan Barcelona house
This two-storey house in Barcelona, renovated by local studio Nook Architects, features joined living and sleeping areas separated by stairs and mesh partitions (+ slideshow). More »
Johansen Skovsted Arkitekter convert 1960s pump stations into river viewing points
Puzzles Architecture adds rusty steel extension to an old Belgian barn
Puzzles Architecture designed this weathering-steel extension for a barn in Belgium, converting it into an annex for the adjacent 18th-century farmhouse (+ slideshow). More »
Richard Lindvall renovates former Stockholm sausage factory for Usine Restaurant
Swedish designer Richard Lindvall has created monochromatic interiors for a refurbished Stockholm factory that now houses a restaurant and conference space. More »
Glazed theatre by van Dongen-Koschuch occupies former dockland buildings
Lee Chul and Liu Jing knock through walls to open up spaces in a Beijing apartment
Design Haus Liberty squeezes three flats into angular period property in east London
Design Haus Liberty has converted a building with an triangular footprint in London's Shoreditch into rental apartments that fold around awkwardly shaped internal walls (+ slideshow). More »
Rick Mather Architects refurbishes and expands London's Lyric Hammersmith theatre
London office Rick Mather Architects has completed an extension to the city's Lyric Hammersmith theatre, adding a new wing that houses facilities including studios for film, dance and theatre (+ slideshow). More »
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