text:
1 1/2 tbsp. flour
Peel and core apple. Cut apple into 8 slices.
Now take soda and pour it around the edges of the crescent rolls.
Printable Recipe Here
I discovered this recipe a few years back...these things are amazing!!!!ReplyDelete
Wow, do those look good!ReplyDelete
Oh wow, oh wow, oh wow. Cinnamon? Yes please. Apples? Yes please. Pastry? Yes please!!!ReplyDelete
This looks great!!! So easy and definitely much faster than making it the traditional way. This is something I could whip up during the week and enjoy all the flavors of Fall :-). Thanks for sharing and have a great weekend!ReplyDelete
Brandie -- that looks wonderful!! Don't we all like an easy-peasy recipe :)
Oh my goodness! Such a simple recipe but it looks soooo good! I would have never thought to use a soda in this! I can't wait to try these!
Thanks for the tip on the Cinnamon! I love Cinnamon, so I'll definitely try the Saigon Cinnamon!
WOW!! These look amazing! I love how easy the recipe is & the soda, brilliant! Wish I could take a bite of one right now. :)ReplyDelete
I love these, look delicious, I love all with apples! gloriaReplyDelete
I love anything with baked apples!! These dumplings look so delicious!! I like that you used the Sprite!ReplyDelete
Wow these are super easy! And look so delicious, I'm definitely trying this! :)ReplyDelete
Looks so delicious. Apple desserts make me giddy. Can't wait to give these a try sometime soon.ReplyDelete
Such a simple recipe but with great outcome, thanks for sharing and am going to try this out soon.ReplyDelete
So simple! Love that - and you could fill it with so many different things...ReplyDelete
I can always count on you for a wonderful treat that doesn't involve spending all day in the kitchen. Great fall flavors in this one-well done.ReplyDelete
You're right! You can't get much easier than this! These dumplins look great!ReplyDelete
Oh yum!! I love how easy these sound. I would prolly have to make 15 batches though to get one since I am surrounded by piggy males :-DReplyDelete
I love apple dumplings. I just so happened to be reading this this morning and my Mom called to ask me what she should have for dessert this weekend when they had some friends over. I said...I have something RIGHT here!! So, she is making them!! Can't wait to try myself.ReplyDelete
I got so excited that you made this and reminded me of it that I pinned it, stumbled it and then left without leaving a note so I had to come back. :)
Thank you SO much for sharing this! Someone brought it to our house for dessert once and I fell in love with it, but haven't thought of it since then. Now I can make it!
Have a great weekend, Brandie.
I made these pre-blogging days with Mountain Dew...so easy and fabulous!!! What a fun and delicious idea~ReplyDelete
Oh I love these. Need to get some fresh apples and get baking!! Enjoy your weekend!ReplyDelete
These look great and so easy!! I never would have thought to pour sprite in the baking dish!!ReplyDelete
Oh yea! This is a favorite recipe that I share often. Thinkin' I'm gonna be makin' these dumplin's very soon. Thanks so much -ReplyDelete
Just made these tonight, and holy crap are they good! Thanks for the recipe! :)ReplyDelete
I've been such a slacker on visiting all my bloggie BFFs blogs! Love the sound of these simple, yet Im sure amazing dumplings!!!! Hope all is well Bran! : )ReplyDelete
These look so good. I want to jump in my computer and eat them. Thanks for sharing with us.ReplyDelete
It's breakfast time in the Sweet Sensations household and I would love to have a couple of these. Great recipe and Congratulations on Today's Top 9!ReplyDelete
Congrats on Foodbuzz top 9!ReplyDelete
Back to say congratulations on the Top 9!!ReplyDelete
Yumm!! We saw this this morning and made for our snack tonight. REally geat with ice cream.ReplyDelete
These sure do look wonderful...ReplyDelete
Oh yum! These look great :)ReplyDelete
Wow! What an interesting recipe! I love apple dumplin[g]s. And I love how simple these are!ReplyDelete
These sound absolutely delicious! Cinnamon, apples, pastry - what is not to love!ReplyDelete
I make these all the time and they are a big hit always!! A little variation...I use peaches sometimes too and they are just as awesome!!!ReplyDelete
Made these Dumplins for my husband on a Saturday and had to make more on Sunday, he loved them! Thanks for one of the easiest recipes ever!ReplyDelete
Mary - thank you so much for taking the time to let me know how these turned out for you! So happy you loved them (and your hubby too!).ReplyDelete
I made these and they were a hit!! I doubled the apples/crescents but I did not double the butter, sugar, vanilla & soda....and they turned out excellent. Thank you so much for the recipe!!ReplyDelete
Ever since the kids saw The Apple Dumpling Gang, they've been wanting to try apple dumplings. These look so easy and delicious, I just might have to surprise them!ReplyDelete
I saw something similar to this in a Taste of Home the other day. I tore it out and it's now residing in my "must cook" file. Thanks for sharing at Church Supper and the tip about the cinnamon!
Everyday Mom's Meals
Don't know how I missed this before but saw it over at Everyday Mom's Meals, Love it, too easy, I'll be making some this week!ReplyDelete
Just had to come back and say, these are delicious! The kids request them at least once a week and since we eat twice off one recipe, we enjoy your apple dumplings for dessert with vanilla ice cream twice a week! YUM!ReplyDelete
Just tried these and love them! I agree about the kind of cinnamon and just so you know, our local Costco carries a huge bottle of it so incredibly cheap compared to what you can buy in the grocery store and it lasts forever.ReplyDelete
Tucson Mom - so happy you liked them! Good to know about it being carried at Costco. We don't have on here but we do have Sam's Club so I'll have to check there next time I go. Thank you so much for taking the time to come back & let me know how they turned out for ya. I really appreciate it!ReplyDelete
These look wonderful, and I love the fact that they are so easy! I'm saving these to try some day.ReplyDelete
These look amazing! One question....I know they're probably best warm, right out of the oven, but how about when they come to room temperature? I was thinking of making these for a spaghetti dinner at my daughter's school.ReplyDelete
These tast just fine at room temperature. In fact, my husband always asks me to make extra so he can take some for lunch the next day. So he's usually eating them cold since they stay in his cooler. To me, they are best warm but he seems to enjoy the taste either way! :)ReplyDelete
Made this tonight and it was delicious!!! Loved it!! My husband was a little skeptical but after he had his first bite - he said it was very good! Thanks for the recipe!!!ReplyDelete
Hi Star! Thank you so much for taking the time to let me know how they turned out for you. I'm glad your hubby gave them a chance..lol!ReplyDelete
I have a pot luck on Saturday and I am supposed to bring a dessert. I think I just figured out what I'm making.
Now I need two appetizers for the pot lucks on Saturday night and Sunday night...
I made them yesterday, super easy super delicious. Used RAW SUGAR and it was awshum!ReplyDelete
If your scared of sweet stay away from these. Oh my goodness these are sooooo good. I have taken these to a church supper and none returned home. lol I also baked some last night and had with ice cream. Yum!! Super easy and super tasty. You will never go wrong making this dessert! lolReplyDelete
Oh my, I just made these! They are sooooo yummy! A little sweet so next time I might cut back on the sugar a little bit. My 5 year old loved them (without the apple LOL). I might have to bring them to our next game night! Thanks for the recipe.ReplyDelete
I made these last Sunday! And, I made 24 of them. I used the cinnamon sugar instead of plain cinnamon and also apples from Mother-in-laws tree. I added about 2 teaspoons of regular cinnamon to the sugar/butter mixture and instead of sprite, I used 7-up! My-my, they were ooohhh, so good!ReplyDelete
Hi :)
I've been following your recipes for quite some time cuz they keep popping up on my fb wall and then I just start browsing thru all ur recipes and lose track of time imagining I'd be able to cook them some day :) they look soooooo delicious!
But when I saw your Easy Apple Dumplings I knew I had to try it! But we don't get Crescent Rolls here...is there anything I can replace it with?
I'm SO happy to hear y'all are loving these!! Thank you so much for leaving such nice comments! Maha - thank you! I wish I knew of a substitution that would work for you. I'm just not that familiar with other products from different countries. I guess maybe you could make them from scratch but then they wouldn't be called Easy Apple Dumplings. And I honestly don't have a from-scratch recipe for crescent rolls. I'm so sorry!
I use this recipe for gatherings all of the time... with one smal change.. try using Code Red Mountain Dew instead of the sprite... it gives it a kick of cherry flavor...I also add cherries at Christmas.. just to make it look a little more like Christmas. Blessings
I have made Apple Dumplins 2 times and had to share the recipe with many gals. Everyone loves it! I did find the Saigon Cinnamon and I think it adds a special touch. Thanks for sharing a great recipe!
Every Sunday, my son and I watch "Once Upon A Time"...Every Sunday, I make an apple dish for us to eat during the show...Being that the main character is Snow White and..well..you remember the story...
I came across this recipe because, quite frankly, I stalk Brandie's page daily. She's directly responsible for getting all these kids of mine fed on a weekly basis...but anyway..
If the smell is any indication, we're going to LOVE these!
Just one dumb question, though...What is the significance of the Sprite in the recipe?
Thanks Brandie!
I was also wondering what the sprite does lol
Waiting in suspense!!
I love this recipe! I have made it over a jillion times, my family, neighbors and friends just love it! It is so easy to make and puts smiles on anyone who tries them :)
You were so sweet to come back & let me know how this recipes has turned out for you. I am so happy you love it so much!ReplyDelete
I tried this tonight and it was delicious I will brush the apples in sugar next time, but other then that I will definitely be using this recipe again...ReplyDelete
I made these dumplins late this morning for lunch. I care-take my parents (85 & 86 yrs. old) and it's not easy to come up with something interesting day-in & day-out. My Mom, Dad & son said it's the best they've ever had! My Mom said, "Send this page link to my sisters, daughter & grandkids; it's that much of a keeper"!
My Dad took care of my Mom until early 2012, when his health started to weaken. He watched me make it and said it's easy enough for even him to make.
Thanks for some of the greatest tasting recipes I've ever found online.
HI Jenny! Thank you so very much! I really appreciate you taking the time to leave a message on here. SO very sweet! I am so happy you found this one to be a "keeper". I hope you find lots more recipes on here that you love!! ~BrandieReplyDelete
Oh my I cant wait to try this one! My problem is which recipe to try first! Yumm.ReplyDelete
I made these tonight and they were absolutely delicious. And they are so easy to make, I will definitely be making them again. I have 2 questions, though. First, what exactly does the sprite/7-up do? Do you have to use it, and do you know how much of a difference it would make to not use it? And second, mine tasted delicious, but unlike the picture you posted of the finished product, mine still had about 1/4" of the butter/soda mixture in the pan. My little dumplins were practically floating even after baking for 40 minutes. The only alterations I made to the recipe were using margarine instead of butter, ( I know, I hate myself for it too hahaha) and I used Mtn Dew instead of sprite. Any insight would be appreciated.ReplyDelete
The recipe only says a 1/2 CUP of soda, not a can or even 1/2 a can. Hopefully you used the correct amount.Delete
I'm just sooooo glad I found your blog. I just LOVE your recipes. It just shouts 'for me'. I love to cook and bake, but most days am too busy to stay in the kitchen long. I can't wait to surprise my husband and kids with some of your delicious recipes. Thanks so much!ReplyDelete
This looks awesome! I like others would like to know about using sprite or other canned drink. I do not drink any of these at all so I would like to leave this out. Can someone share the purpose of using it as well as what could be used in place of the drink or can it be excluded all together. I would like to make these for my mother who is diabetic so that would be another reason to exclude all the sugar in the drink.
Thank you for your time.
My mother made this recipe for many years and always used orange juice...it was delicious.Delete
This recipe is awesome. I've used ordinary cinnamon, but added 1/4 teaspoon of freshly grated nutmeg. This is AWESOME!!!!ReplyDelete
Great recipes! Thanks so much for sharing♥ReplyDelete
My husband does not eat desserts OR fruit. But THIS he loves!ReplyDelete
Just made these...YUM!! The hardest part of making them was getting the apple corer to go thru the crisp apple.ReplyDelete
What can I substitute for the lemon lime soda for someone with citrus allergies?ReplyDelete
yes, Dr pepper, dash or 2 of vanilla, anything!!Delete
I just loveee all the recipes this page posts!ReplyDelete
I just love these! My husband loves them more! I've been making them for about a year now and decided to "play around" with it a little. So, another great fruit that works well in this is Peaches! Turns out awesome too!ReplyDelete
Just made these for a party and they were a HUGE hit. Everyone wanted the recipe. Going to make them for Thanksgiving as well. Not that it matters, since they are so full of calories anyway but I cut out just a few by using a Sprite Zero because that was all I had on hand. You would never have known!ReplyDelete
My husband and I just finished these and everything about it was wonderful. It was soft, crispy and buttery and easy. I used a little allspice and raisins. I cant wait to try it with peaches. Thank you so much.ReplyDelete
I add my soda to my wet ingredients, it foams a little and then pour it directly on the dumplings ...sometimes I sprinkle brown sugar light over top before baking...Never tried w/peaches...that sounds great ..ReplyDelete
Will definitely have to try this!ReplyDelete
Just took from the oven ..delicious ...simple - literally 5 min to prepare. . Looks and tastes like you went to a lot of trouble .Thank you :)ReplyDelete
I have a question, I made these over christmas and thay were great! but i sprayed my square glass bakeing Dish with the pam non stick spray and when thay cooled off and i had put them in the refergerator due to i was not sure if these Dumplins could sit out or not well thay really stuck to the pan Do you have any sugestions for me so next time i make them thay will not stick to the pan???? Thank you!ReplyDelete
Thank you Brandie for this very, very delicious recipe. I'm german and also live in Germany, but after 2 vacations in the USA we love american food. Also some of our friends love it. Thank you so much for sharing.
Loni (Germany)
This sounds wonderful! I can't wait to try! For those trying to avoid the citrus , I would suggest using ginger ale. I'm thinking it would be a plus addition to the taste as well as the aroma. That is what I plan to use. For those trying to keep their sugars or carbs low, (diabetics) use a combo of alternative sugars (I like to use Splenda and stevia) and then use a diet soda.ReplyDelete
My friend hooked me up with this recipe year, n i TOTALLY love these!!! So easy, the kids love them, n doesn't take a ton of money for the ingredients....So i make them all the time lol so yum....ReplyDelete
Two tips:
To keep it from sticking, you can use parchment paper.
For the person who is allergic to citrus, what about just using sparkling water with some sugar added to it?
I just tried these...yummy! I used reduced fat crescent rolls (that's what I had on hand). There was lots of butter left in the pan when I was done, so next time I will try cutting it in half and maybe increasing the 7-Up. May also try a little less sugar. Such a great "base" recipe to play with...thanks!
Gonna try this, sounds delious! But what is the soda for and is their a replacement?
Quick question - could you use Splenda (truvia, etc.) instead of sugar? and could you use "diet" 7-up?
These were good but needed to amp them up a bit. Instead of cinnamon on the roll up it was brown sugar. I lightly salted the apples - once rolled up I sprinkled sugar/cinnamon over the top. The sugar/butter/vanilla mixture was added when it was foaming - almost like marshmallows.... poured over the top... added the squirt. You can't eat just one!ReplyDelete
Omgoodness. This had got to be the best thing. Ever!!! It's a combo of all my favorite thing. I literally just made it and ate one. My house smells like movie popcorn, fresh bread and Apple pie. My three favorite smells. At first I thought I used too much liquid bc it was covering half of the wrap but the crescent roll soaks it up. The bottom is ooey gooey and the top is munchy crunchy and best of all, they're small, quick and the easiest recipe for even beginner bakers like me. I can go on and on about how it's my new favorite thing in the world. This is going on my holiday menu. Thank you!!ReplyDelete
OMG THIS IS ONE OF THE BEST APPLE DESERT EVER I TRIED IT AND EVERYONE LOVED IT. And Very easy...look forward to more ideas..... thank you...ReplyDelete
Question...dies the bottom become soggy? They look delicious, but wonder how soft/soggy the bottoms are.ReplyDelete
Hi, Iive in Australia and would love to make these but, we don't have crescent rolls here. Would it still work if I made them with puff pastry? Love your recipes.ReplyDelete
I want to try these but just curious as to what the purpose of the soda is? Im not a baker by no means so was wondering. ...thanksReplyDelete
Okay for starters I'm a guy and this looks like something that I won't mess up but you don't say how much pop to put in (we say pop on the west coast). I'm thinking not the whole can. :)ReplyDelete
i loved these for the taste and simplicity, but i did feel guilty about all the butter and sugar used. in fact, right after baking, i poured the excess 'sauce' off so the dumplings weren't sitting in them. I wonder if there were any variations I could do to take some of the calories out of the recipe?ReplyDelete
I use cinnamon sugar and a dash of nutmeg just to give it the apple pie flavor. It is really good. I had to make these every other day for two weeks as no one could eat just one!!ReplyDelete
A&W diet cream soda..just 1/2 cup..
(No citrus..no sugar)but still very sweet and organic brown sugar wih the cinnamon.
I had to try them, just out some in the oven, will let you know how they turn out. They already smell so good.ReplyDelete
I have just taken these out of the oven and my kitchen is smelling so nice with cinnamon, I will reheat for dinner in about 4 hours. Can't wait, thanks for the recipe. PS I used pastry
I cook a few raisins and added to mine. Also try Williams and Sonoma cinnamon the best.ReplyDelete
Awesome recipe! I used Granny Smith apples, margarine instead of butter and Mountain DewReplyDelete
I just made these. And OMG I couldn't wait for them to cool, they smelled so wonderful..
I ate two and went back for two more with aliitle whip cream. I will definitely be making
these again. Thanks for sharing your moms recipe.
I have made these and they are sooooooo yummy. They are rich! My grandson has asked for them for the family July 4th cookout. I don't think they will last long.ReplyDelete
instead of soda how about apple cider? The soda just doesnt sound good to me. I think I shall try the cider or juice firstReplyDelete
I would use ready made puff pastry, and no soda...I like the idea of using apple cider as "Drama Queen" suggested. :)ReplyDelete


text: Take a deep breath and off you go! Just after setting off, you will find yourself literally going in circles. At 9 m high, Switzerland's only 360-degree loop will give you your first kick – to be followed by others like it when the bob hurtles into the notorious "jump bends". The 900-m-long run ends with three crazy jumps.

subset: commoncrawl


text:
Source: Foss Patents
quote: When I am stating facts
quote: Apple wanted to preserve their (very normal) right to challenge the validity of the patent in the first place, not a 'provision to later prove them invalid' - which is very misleading.
quote: Apple apparently made an offer to license the patent on FRAND terms going forward. But the matter was complicated by the fact that Apple's agreement included a clause that would allow it to try and have the patent invalidated if Motorola tried to seek damages for past infringement over and above the agreed FRAND rate. Apple is in fact contesting the validity of the patent in suit in another federal court in Germany. Obviously it doesn't want to have to pay for infringing a patent that might not be valid. Unfortunately, the issue of past infringement of standards-essential patents hasn't previously been addressed in the relevant cases in Germany. As Motorola's legal team successfully argued, if a patent is infringed without a valid license, there should be some punishment in the form of monetary compensation. While competition law may require patent holders to honor FRAND agreements and offer a license going forward, the court agreed that past infringement should be treated differently.
quote: No you don't - that's like saying let's agree to pay x amount of something, but wait till I rule it invalid so you get nothing period.


text:
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text:
Sources: Google, Infrequently [Google Chrome Engineer]
quote: what I did say is that the competition in the mobile OS market is very limited, and that the notion that Google is not "charging" for what they are apparently "giving away for free" is heavily misguided.
quote: Even if you do not use google's services, websites that you visit may use Google's ads or analytics - both track your movements over the web as well as a lot of other info about what you do...so not using google isn't somehow shielding you from their tentacles.
quote: Android in itself may not make a case for google being a monopoly, but when it is considered together with all of googles business activities as a whole, you'd have to be very dim-witted to say that google is not effectively "controlling" the internet. Maybe not exclusively...yet.
quote: Being able to "do what you want" with android does not preclude it from becoming a contributing factor to google's eventual monopoly over modern communications.
quote: What I was saying: Google is giving Android away for free.You can use, modify and do whatever you want with it and don't have to pay Google anything in whatever form you want. ONLY if you want to use the optional Google services like Maps, Store, ... you have to accept some restricitions, otherwise, Google is giving it away for free and nothing is misguided.
quote: If you're lazy and turn on Cookies, remain logged in, ... only then Google/Facebook/... is able to track you. You can surf in private mode, or just don't use the comfort functions like always logged in.
quote: No ad company can track you across more than 1 session or even more than 1 browser window. But people are lazy, people enjoy using the like button on each site, that's not an issues of Google, but of the people. I'm free to not use and even block it, and you know what? I blocked it.
quote: Amazon, MS, Apple, Facebook, are just too large and popular to change this.
quote: So as long as you can use on Android whatever software you like, and as long as Google publishes the source code of the latest iterations and as long as you are free to use it without Google, there's no reason to fear.


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text:
SALEM - New Year's Eve Salem remains two weeks away, but the menu is set, the entertainers are booked and the tickets are available to purchase - now organizers just need some volunteers.
In its ninth year, the alcohol-free, family-focused event tends to fall together easier than in the first few years, which NYES coordinator David Schwartz attributes to the great six-member volunteer committee of coordinators working in different areas, including musicians, clerical and promotional people.
"Together, we just make a good group," he said.
Article Photos
Salem High School sophomore Ivy Koons, center, submitted the winning design to be used on New Year's Eve Salem posters this year, selected from many entries by high school art students. Pictured with Koons from left are, NYES coordinator and performer Bill Schilling, SHS art instructor Lisa Frederick, Koons, SHS junior Courtney Warneke with her runnerup entry and NYES coordinator and performer John Gilbert. Advance tickets are on sale now for New Year's Eve Salem for $5 at all Salem area banks, Salem Giant Eagle, Salem Historical Society, Salem Community Center and Salem Chamber of Commerce. Learn more: www.newyearsevesalem.com. (Salem News photo by Mary Ann Greier)
In a press release issued Sunday, he called the volunteers - the people who watch the entrances to the venues, sell and take tickets, hand out beads and answer questions - the backbone of New Year's Eve Salem.
All volunteers working two or more hours will receive a New Year's Eve Salem admission ticket good at all entertainment venues. People of all ages, couples and families can volunteer by calling the New Year's Eve Salem hotline at 330-817-6693 and leaving a
message with their name, phone number and number of people volunteering.
Someone will call back about the orientation meeting set for Dec. 30 at the Salem Chamber of Commerce meeting room, with entry through the door off of the alley beside the building.
New Year's Eve Salem includes six different venues covering rock-n-roll, gospel, bluegrass, country and folk music, children's entertainment with a magician, a ventriloquist, and a singer, and venues with a model train display and a historical display. Food offerings will include pizza at every site, a hot dog bar and kielbasa and a turkey dinner.
The Kent State University City Center will have rock 'n' roll, the Salem Masonic Temple will feature bluegrass and country, the Church of Our Saviour (Episcopal) will offer old-fashioned gospel, all starting at 6 p.m. and the Memorial Building will offer the children's venue beginning at 5:30 p.m. Beginning at 8:30 p.m., the red room on the third floor of the Memorial Building will feature folk music.
Train enthusiasts can visit the Sugartree Alley Railroad Depot at the rear of Fred Naragon's law office to see the model train display from 6 to 10 p.m. History buffs will have the opportunity to see Music and Toys of the Baby Boomers at the new Dale Shaffer Research Library off of South Lundy Avenue from 4:30 to 8 p.m.
New entertainment this year will include local popular country/rock artist Zach Paxson at the Masonic Temple, the Loving God Gospel Quartet at the Episcopal Church of Our Savior and ventriloquist Daniel Jay at the Memorial Building.
Robert Zelenek, an 86-year-old World War II veteran from the area, will play guitar and sing during Abbey Road's first set at the KSU City Center.
Return acts who weren't involved last year include Salem's Ted Thorne at the gospel venue and Jason Alan with his magic show at the Memorial Building.
The rest of the lineups include: the Sugartree Alley steel drum band, Abbey Road and the Tribute Band at the KSU City Center; Allegheny Drifters and the Stockdale Family Band at the Masonic Temple; God's Quad and Bill Schilling & Linda Sigismondi at the Episcopal Church of Our Savior; and Chip Richter and The Chip Munks Band at the children's venue in the Memorial Building. Schilling and Sigismondi and Dulci-More will perform folk music in the red room at the Memorial Building.
A grand finale featuring performers from the various venues, a balloon drop and the singing of "Auld Lang Syne" will take place at the KSU City Center beginning at 11 p.m. and ending after midnight.
Tickets for New Year's Eve Salem cost $5 for advance tickets or $8 for tickets sold after Christmas or at the door. All children under 10 years of age are free with a paid adult accompanying them.
Tickets can be purchased at Salem Giant Eagle, Salem Community Center, all Salem banks, Salem Chamber of Commerce and the Salem Historical Society.
Mary Ann Greier can be reached at firstname.lastname@example.com


text:
Developer Platform Summary - Kevin Gallo, Windows Phone 8
- Speakers: Kevin Gallo
- 2 comments
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Kevin quickly highlights the key points of the Windows Phone 8 developer platform.
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text:
Top Definition
The male genital sensation that accompanies swift drops or long falls which cause the penis and testes to rise slightly in reference to the rest of the body. The sensation is comparable to a momentary weightlessness of the genitalia.
Hoverballs, my dear sir. That was hoverballs.
автор: Passionateballs 15 июля 2010
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Featured StoryHess Pledges $4.4 Million to UW for Energy Research
January 18, 2013 — Hess Corporation has committed to giving the University of Wyoming $4.4 million to support UW's Center for Advanced Oil and Gas Technologies Nano Resolution Imaging Laboratory, Governor Matt Mead and UW President Tom Buchanan announced today (Friday).
January 3, 2013 — During the past 13,000 years, Wyoming's Bighorn Basin has experienced significant increases in population growth -- due primarily to periods of high effective moisture and moderate temperatures -- according to three University of Wyoming professors. By contrast, when water levels were lower and temperatures higher, the state's populations of hunter-gatherers decreased or may have even disappeared altogether, they concur.
January 10, 2013 — Papers of Jack Benny, one of the 20th century's most influential entertainers, are now accessible online at the University of Wyoming's American Heritage Center.
January 7, 2013 — After its first makeover in nearly 60 years, the University of Wyoming's Geological Museum is ready to reopen to the public.
January 14, 2013 — Miss Wyoming Lexie Madden, a University of Wyoming student from Torrington, was named third runner-up at the Miss America Pageant on Saturday night in Las Vegas.
January 14, 2013 — A Drilling Simulator Teaching Lab is expected to expand course offerings in engineering at the University of Wyoming, provide students and industry personnel drilling experience, and will eventually offer professional well control certifications for drillers.
January 15, 2013 — A $2 million gift commitment from Ultra Petroleum Corp. will support and enhance the University of Wyoming's energy research and academic program, the university announced today (Tuesday).
January 18, 2013 — Hess Corporation has committed to giving the University of Wyoming $4.4 million to support UW's Center for Advanced Oil and Gas Technologies Nano Resolution Imaging Laboratory, Governor Matt Mead and UW President Tom Buchanan announced today (Friday).
January 25, 2013 — New transmission and generation infrastructure, relative to power generated by Wyoming's vaunted wind, would help diversify the state's economy with more high-paying jobs -- both during the construction and operation phases -- while providing economically priced renewable power to California, according to a recent study conducted by the University of Wyoming's Wind Energy Research Center.
January 28, 2013 — Are you searching for more funding sources for your program or research?
January 30, 2013 — One of the University of Wyoming's newest professors has tackled a decade-old question regarding the evolutionary origins of modularity and discovered a new theory for why biological entities are organized into modules.
February 1, 2013 — A team of scientists led by a University of Wyoming researcher recently reported that the size of trophy horns and antlers of most species of North American big game has declined slightly over the past century, most likely as a result of intensive harvest of males.
February 11, 2013 — The University of Wyoming's Berry Biodiversity Conservation Center, home to Laramie's only living roof, has been awarded LEED Gold certification for its environmentally and user-conscious building features.
February 7, 2013 — A grant from ExxonMobil will support science and technology education programs at the University of Wyoming, including research into technologies that improve the production of oil and gas, UW announced today (Thursday).
February 12, 2013 — To Ye Zhang, sequestering and storing carbon dioxide in deep subsurface reservoirs offers potential environmental benefits. But she also knows the process is primarily a "cost center," meaning there is no money to be made from such ventures.
February 15, 2013 — University of Wyoming senior Stacia Slowey of Thornton, Colo., has been selected as one of the American Society of Civil Engineers' 2013 New Faces of Civil Engineering – College Edition.
February 19, 2013 — A scholar in cell biology and neuroscience who has served as a dean at two universities has been named dean of the University of Wyoming College of Arts and Sciences.
February 22, 2013 — Six will perform. Only one will be chosen as the University of Wyoming's finest student musician during the Dorothy Jacoby Student Soloist Competition Friday, March 1, at 7:30 p.m. in the Fine Arts concert hall.
March 7, 2013 — Steady enrollment growth is continuing at the University of Wyoming, with 12,873 students enrolled for the spring semester.
March 13, 2013 — Faculty members at the University of Wyoming received a record $86 million in external funding in the 2012 fiscal year.
March 13, 2013 — Two-time Pulitzer Prize-winning historian and author David McCullough will speak Tuesday, April 16, at the University of Wyoming. His talk is free and open to the public.
March 6, 2013 — Wyoming First Lady Carol Mead will host a community literacy forum Friday, March 8, at 11:45 a.m. at the Albany County Library Meeting Room. The meeting is free and open to the public.
March 1, 2013 — University of Wyoming Department of Theatre and Dance students and faculty were honored this spring at the Region VII Kennedy Center American College Theatre Festival (KCACTF) and Northwest Drama Conference (NWDC) at California State University in Sacramento.
March 6, 2013 — For as long as she can remember, Amy Banic has been fascinated with human-computer interaction and virtual reality. That fascination has become the basis of her scholarly research -- and all in 3-D.
March 6, 2013 — Violin virtuoso Ara Harutyunyan of Yerevan, Armenia, was named the winner of the University of Wyoming's Dorothy Jacoby Student Soloist Competition March 1, at the Fine Arts concert hall.
March 9, 2013 — There's a reason all those 7-mile trail runs in the mountains and 6 a.m. roller skiing treks to the outskirts of Laramie this summer were scheduled for the University of Wyoming men's Nordic ski club team. Those grueling weekly workouts paid off for a rebuilt Cowboys team.
March 11, 2013 — When Kira Cheshier began to prepare for the annual Art Directors Club Denver Student Exhibition, she was aware that University of Wyoming students had traditionally held their own in the region's premiere exhibition for graphic design and advertising.
April 29, 2013 — For nearly 22 years, Charles Dolan taught the importance of building a solid foundation with structural integrity. And he often did it with cultural flair, citing the Sword of Damocles as a metaphor for the consequences of structural failure or quoting Babylonian King Hammurabi to demonstrate the outcome -- in the king's words, death -- of faulty construction.
April 3, 2013 — Acclaimed violinist Ray Chen will perform at 7:30 p.m. Tuesday, April 9, in the University of Wyoming Fine Arts concert hall.
April 15, 2013 — Bruce Culver, director and professor in the School of Pharmacy, and Kristy Isaak, accounting associate, senior, in ASUW, were named the 2012-2013 recipients of the University of Wyoming's James C. Hurst Each Student-A Person award.
April 23, 2013 — University of Wyoming students will showcase upper-level junior and senior graphic design portfolios from 6-8 p.m. Friday, May 3, in the Visual Arts Building lobby.
April 26, 2013 — Amanda King, who will graduate in May with an international studies degree with specialization in the Middle East and Africa, is the recipient of the Rosemarie Martha Spitaleri Award as the University of Wyoming's outstanding graduating woman.
April 24, 2013 — With three semesters remaining before he graduates from the University of Wyoming, Shawheen Amirkhizi, an accounting junior from Evanston, already runs his own business. The next step: grow his small independent company into a top competitor in its specialty field.
April 22, 2013 — University of Wyoming Libraries has presented its Outstanding Staff Award to Nancy Cyrus Marlatt, marketing and public relations coordinator. The award recognized her contributions during 2012.
April 29, 2013 — The University of Wyoming offers an anonymous text tip program that will help create a safer community. Tip411 is an Internet-based tool that enables the public to text message anonymous tips to the university police and lets police respond, creating a two-way anonymous chat.
April 30, 2013 — Five University of Wyoming students are the recipients of Northern Arapaho Endowment Scholarships for the coming summer session and the 2013-2014 academic year.
April 1, 2013 — Research and commitment to teaching have earned an assistant professor of horticulture in the University of Wyoming Department of Plant Sciences the 2013 Young Scientist Award from the Society for In Vitro Biology.
April 8, 2013 — Led by its strong contingent of ropers, the University of Wyoming men's rodeo team placed first at last weekend's Lancer Rodeo at Eastern Wyoming College (EWC) in Torrington.
April 24, 2013 — Researchers at the University of Wyoming Carbon Management Institute (CMI) discovered a vast new lithium resource near Rock Springs during a geological carbon dioxide storage site characterization project sponsored by the U.S. Department of Energy.
April 25, 2013 — Paula Weems, office assistant, senior with the UW Admissions Office, today (Thursday) was named the University of Wyoming's outstanding employee of the year during the annual Staff Recognition Day at UW.
April 2, 2013 — A leading Parkinson's disease researcher will discuss his work Thursday, April 4, at 7 p.m. in Room 129 of the University of Wyoming Classroom Building.
May 6, 2013 — A committee of University of Wyoming Student Alumni Association members has selected Brett Deacon, Department of Psychology associate professor, as this year's Outstanding Faculty Award recipient.
May 20, 2013 — The University of Wyoming College of Engineering and Applied Science recently recognized faculty and staff for outstanding service and accomplishments.
May 14, 2013 — Open houses in Laramie, Saratoga and Steamboat Springs, Colo., will highlight ecological dynamics as local forests respond and move beyond the bark beetle epidemic.
May 9, 2013 — Four University of Wyoming students will gain experience teaching science -- to elementary school students in the outdoors -- in Saratoga this summer.
May 10, 2013 — Citing retiring President Tom Buchanan's dedication to the arts in Wyoming, the University of Wyoming today (Friday) broke ground to begin construction on the new Buchanan Center for the Performing Arts.
May 1, 2013 — An internationally recognized scientist in climate modeling, aerosol-cloud reactions and aerosol modeling is the newest endowed chair at the University of Wyoming.
May 30, 2013 — Beginning this week, six undergraduate students from across America have gathered for 10 weeks to delve into studying astronomy at the University of Wyoming. And there's no easing in. Students were scheduled to gaze at stars through a telescope on their first night.
May 6, 2013 — David Whitman, a University of Wyoming professor of electrical and computer engineering, was recently named an American Society for Engineering Education (ASEE) Fellow.
May 9, 2013 — Marc Wall, the U.S. Pacific Command's foreign policy adviser and a former United States ambassador to Chad, is the new Senior Visiting Scholar in Global Studies at the University of Wyoming.
May 8, 2013 — PlanktOMICS Algae Bioservices recently finalized a spin-out agreement with the University of Wyoming in a deal that will allow the company to further its goal to be an innovative leader in providing biotechnological services and products for the emerging algal biomass industry.
May 21, 2013 — Two dozen University of Wyoming undergraduate students will have great opportunities to become involved in scientific research this summer.
May 13, 2013 — The University of Wyoming awarded this year's President's Faculty Stewardship Award to Jean Garrison, director of the Global and Area Studies program and professor in the Department of Political Science.
May 16, 2013 — A longtime University of Wyoming faculty member, who has served in various leadership capacities and has a record of service around the state, has been named the next dean of UW's Outreach School.
May 14, 2013 — The University of Wyoming College of Arts and Sciences has selected its outstanding graduating students for the 2012-13 academic year.
May 6, 2013 — Deborah McCarthy, head of Technical Services at University Libraries, is the recipient of the University of Wyoming's 2013 Milstead Distinguished Librarianship Award.
June 4, 2013 — Diane Boyle, a prolific researcher and award-winning teacher, is the first excellence chair at the University of Wyoming's Fay W. Whitney School of Nursing.
June 24, 2013 — In recognition of his groundbreaking accomplishments in a career spanning five decades, the world's largest professional organization of ecologists has presented its top award to William Reiners, professor in the University of Wyoming Department of Botany.
June 4, 2013 — A Laramie-based business that grew from an idea at the University of Wyoming into a thriving company that was eventually acquired by a Fortune 350 software giant will be the topic of discussion at e2e Casper's networking program this month.
June 27, 2013 — For Carlos Martinez, the University of Wyoming is worlds away from his home in Bogota, Colombia. But for the Jackson State University (JSU) junior, the skills he developed and experience he gained using new hydrology equipment will be invaluable to his future plans.
June 3, 2013 — Jo Chytka is the new director of the Peter M. and Paula Green Johnson Business Career Center at the University of Wyoming College of Business.
June 21, 2013 — The Laramie Mural Project fundraising campaign is under way online at Kickstarter, with a goal of adding seven new murals to downtown Laramie by the end of next summer.
June 17, 2013 — Wyoming residents will have the opportunity to record, share and preserve their stories when the StoryCorps' MobileBooth stops in Wyoming this summer.
June 14, 2013 — During his 35-year career at the University of Wyoming, retiring President Tom Buchanan has accumulated a large and wide-ranging personal collection of books.
June 4, 2013 — A free public reception to open the University of Wyoming Art Museum summer exhibitions will take place Friday, June 7, from 6-8 p.m.
June 21, 2013 — How much weight can a cockroach pull, and how much strength does it take to pull a marshmallow apart?
June 13, 2013 — Two University of Wyoming faculty members are part of the HELIOS software development team that won the 2013 Schroers Award for Outstanding Rotorcraft Research from the San Francisco Bay Area Chapter of the American Helicopter Society (AHS).
June 13, 2013 — A University of Wyoming professor co-wrote a paper that purports a planet may be nestled in a gap in the disk around the star known as TW Hydrae, which is located 176 light years away.
June 17, 2013 — Kaycee Nelson couldn't bear to watch. She had her back to the arena after briefly taking the national breakaway roping lead, and needed two other competitors to somehow falter down the stretch.
June 25, 2013 — University of Wyoming Religious Studies Professor Paul Flesher was part of the excavation team which unearthed a pair of stunning mosaics decorating the floor of a late Roman (fifth century) synagogue at Huqoq in Israel's Lower Galilee.
June 6, 2013 — Three University of Wyoming students have been awarded UniWyo Federal Credit Union Study Abroad Scholarships to study overseas.
September 13, 2013 — The University of Wyoming celebrated the Marian H. Rochelle Gateway Center in a topping-off ceremony Thursday (Sept. 12). The ceremony marks a high point in a facility that will serve UW students for generations.
September 12, 2013 — For the second time in two years, the University of Wyoming's nationally recognized men's and women's Nordic ski club teams have been invited to compete in in the World University Games -- this time Dec. 11-21 in Trentino, Italy.
September 13, 2013 — In an effort to help reduce a nationwide maternal obesity epidemic, the National Institutes of Health has awarded a five-year, $1.5 million grant to researcher Stephen P. Ford, director of the University of Wyoming's Center for the Study of Fetal Programming.
September 16, 2013 — Helping hands are being sought for the annual Laramie Community Service Day on Saturday, Sept. 28.
September 17, 2013 — The University of Wyoming will launch its new nationally accredited Professional Land Management program with a celebration Monday, Sept. 23, from 1-5 p.m. at the UW Energy Innovation Center.
September 23, 2013 — "This is the West … Forever Brown and Gold" is the theme of the 2013 University of Wyoming Homecoming, Oct. 5-12.
September 25, 2013 — Award-winning author and poet Sherman Alexie will lecture and sign books Tuesday, Oct. 15, at 7 p.m. in the University of Wyoming College of Arts and Sciences auditorium. The event is free and open to the public.
September 30, 2013 — Maggie Farrell, University of Wyoming libraries dean, is one of two candidates for the 2015-16 presidency of the American Library Association (ALA).


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Ben and Ryan Explain: AMD Processors
- Posted: Sep 09, 2011 at 9:39AM
- 1 comment
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Ben the PC Guy and Ryan Asdourian take you on a tour of AMD's latest processors.
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You make it sound like these APU's are as good as a dedicated GPU. WTF!
That's an outright lie.
apu's do not even come close to the performance of a dedicated gpu card.
Yes they can play new games BARELY like 5 to 15 fps, able to run the game is one thing, the game being playable is another.
APU's are not for playing fps games. Do not trust these guys, do research before buying anything!
I'm guessing you get paid to say this bullshit but come on enough already !
Tricking people is illegal, think about that.
"The pc guy" my *...
If you want to REAL reviewer of computers and other hardware then cough up some verifiable performance numbers, saying something is "good" doesn't tell us anything.
Gee! you want to make a show but are too lazy to do it right, same mistake over and over again, are you incapable of learning at microsoft ? Is it an american thing or just a microsoft thing ?
God, incompetence and lazy stupidity piss me off ! Now i have to check my blood sugar again, damn it
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On any given day, any one of the top-tier racing veterans in the Tahoe Basin Ski League was capable of laying down a winning run.
In the biggest races of the season last week - the NIAA Division I-A Tahoe Basin Ski League state championships at Sierra-at-Tahoe - it was North Tahoe's Garrett Driller and Francesca English who earned final bragging rights.
Driller won individual titles in both the giant slalom and the slalom, giving him the combined title as well, while English won the GS championship and was second in the slalom to bring home the girls combined title.
North Tahoe also claimed the girls GS team championship and the boys combined, while Truckee's boys won the team slalom title.
The top three schools during the regular season - North Tahoe, South Tahoe and Truckee - were allowed to bring their best eight boys and best eight girls. The rest of the schools, meanwhile - Whittell, Incline, Douglas and Carson - received wild-card entries based on individual point standings.
The state championships kicked off with the GS on Monday and wrapped up with head-to-head, dual-elimination slalom races on Tuesday.
Driller captured the GS title ahead of runner-up Scott Lebel of Truckee and Hughston Norton of Whittell, while Truckee's Nico Kuyper was fifth. Driller then eliminated racer after racer in the dual-elimination slalom before defeating South Tahoe's Alec Jobbins in the final. Lebel finished third in the slalom, while Truckee's Wes Harrington and Kuyper and North Tahoe's Lucas Earley all skied into the quarterfinal round.
Lebel finished runner-up to Driller in the combined. Connor McKeen of South Tahoe was third and was followed by Jobbins and Kuyper.
With two racers in the top five, South Tahoe's boys took the team combined title with 201 points to Truckee's 199 and North Tahoe's 184. Truckee's boys, with three racers earning top-five finishes, won the slalom with 97 points to South Tahoe's 94 and North Tahoe's 79. South Tahoe's boys claimed the GS team win, posting 107 points, while North Tahoe was second with 105 points and Truckee third with 102.
On the girls' side, North Tahoe claimed the combined team title with 199 points. South Tahoe's girls were second with 189 points and Truckee's girls rounded out the combined results with 186 points. The Laker girls also won the GS championship, with 109 points to Truckee's 98 and South Tahoe's 92, while the South Tahoe girls won the slalom title with 97 points to North Tahoe's 90 points and Truckee's 88.
Individually, English finished first in the GS on Day 1 and was runner-up to Whittell wild card Michael Gardner in Tuesday's dual slalom, which was good enough to be crowned the combined champion ahead of Gardner and Truckee's Mo Lebel.
Maia Bickert of South Tahoe was second in the GS and Truckee's Mo Lebel and Sabrina Futrol placed third and fifth, respectively. Mo Lebel recorded a fourth-place finish in the dual slalom, while Futrol and the Lakers' Bozhie Pokorney skied into the quarterfinals. Futrol was fifth in the combined.
Also awarded at the state championships were the Tahoe Basin Ski League's All-League team, as well as the final team standings from the regular season.
Truckee's Colin Gerrard was second in the All-League standings, North Tahoe's Nico Monforte was seventh, Harrington was eighth, and North Tahoe's Drew Austin was ninth and Harrison Goss 10th. Connor McKeen of South Tahoe accumulated the most points for league MVP honors.
In girls All-League, Gardner was the MVP and was followed by Bickert and North Tahoe's Jessica Tidd. Pokorney was eighth, and teammates Johanna Gur and Nicole Marinoff were ninth and 10th, respectively.
North Tahoe's girls won the regular-season title ahead of South Tahoe and Truckee. South Tahoe took the boys regular-season title in front of Truckee and North Tahoe. And in the combined, South Tahoe finished first while North Tahoe was second and Truckee third.
- Tahoe Daily Tribune sports editor Becky Regan contributed to this story.


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Men's Hoops Hosts Toledo Wednesday in MAC West Battle
MUNCIE, Ind. -- The Ball State men's basketball team welcomes Mid-American Conference West Division preseason favorite Toledo to Worthen Arena for a 7 p.m. matchup Wednesday.
The Cardinals (8-10, 2-4 MAC) are coming off a thorough, 82-62 road victory Saturday at Miami University. Toledo (7-10, 3-3 MAC) also won Saturday, taking down Bowling Green by a score of 75-62.
Live Coverage
• Radio (Flagship): Ball State Radio Network (104.1 FM WLBC); Play-by-play: Joel Godett; Analyst: David Eha
• Radio (Student): Sports Link Radio (91.3 FM WCRD); Play-by-play: Sean Stewart; Analyst: Donnie Kolakowski, Tyler Bradfield
• Internet: Live video, audio and stats at ballstatesports.com
The Matchup
• Ball State trails 42-39 in the all-time series against Toledo.
• The Cardinals are 25-13 against the Rockets in Muncie, including an 18-4 mark in Worthen Arena.
• Ball State has won three of the past four meetings over the past two seasons.
• The teams split two meetings last year with the Cardinals posting a 70-68 win last January at Toledo and the Rockets claiming a 63-55 victory last February in Muncie.
• Ball State's Jesse Berry averaged 17.5 points over the two games with Toledo last year, connecting on 12 of 23 shots from the floor, including 9 of 16 from 3-point range.
A Quick Look at the Cardinals
• Ball State snapped a four-game losing streak Saturday with an 82-62 road win at Miami University to improve to 8-10 overall and 2-4 in the Mid-American Conference.
• The Cardinals pulled away down the stretch, using a 12-0 run to turn a 58-54 advantage with less than six minutes to play into a 16-point lead. They went on to extend the lead to as many as 22.
• Junior forward Majok Majok led all players with 21 points and eight rebounds, while junior guard Jesse Berry poured in 20 points and knocked down a career-best six 3-pointers.
• Junior forward Chris Bond stuffed the stat sheet with 16 points, seven rebounds, four assists and five steals, while Jauwan Scaife added 14 points and dished out a career-high seven assists.
• For the season, a trio of Cardinals leads the team offensively with remarkably similar offensive production. Berry -- a preseason all-conference selection -- and Majok are each scoring 12.6 points per game, followed closely by Scaife at 12.2 per game.
• Majok, who leads the MAC and ranks 16th nationally in rebounding, is one of 16 players in the country averaging a double-double at 12.6 points and 10.1 rebounds per game.
• Ball State is scoring 63.2 points per game as a team and allowing 66.2.
Scouting Toledo
• Toledo snapped a three-game losing streak Saturday with a 75-62 home win over Bowling Green to improve to 7-10 (3-3 MAC).
• The Rockets' three MAC losses have come against East Division co-leaders Ohio (76-67) and Akron (71-56) along with West Division leader Western Michigan (79-56).
• Junior guard Rian Pearson leads Toledo with 18.2 points and 6.5 rebounds per game, while sophomore guard Julius Brown adds 13.4 points and hands out a team-best 5.2 assists per game.
• Toledo, the preseason MAC West favorite, is scoring 69.6 points per game and allowing 67.9.
• The Rockets lead the conference with a 78.6 percent team free throw percentage.
More on Saturday's Win at Miami
• Ball State scored a season-high 82 points in the win at Miami and shot 57.7 percent (30-of-52) from the floor as a team, including 68.0 percent (17-of-25) in the second half.
• The Cardinals held a decided advantage on the boards, out-rebounding the RedHawks 37-17.
• The victory was the first for BSU at Miami's Millett Hall since 2004 and just its second since 1992.
• The 20-point margin of victory was the largest for the Cardinals since the season opener against Grambling State and their largest over Miami since 1980.
Majok Named MAC West Player of the Week
• Junior forward Majok Majok was selected Monday as the MAC West Division Player of the Week after averaging 17.0 points and 7.0 rebounds over games last week against Buffalo and Miami.
• He shot 64.7 percent (11-of-17) from the floor and 85.7 percent (12-of-14) from the free throw line for the week on the way to his second player-of-the-week award this season (also on Dec. 10).
Others Also Impressive Last Week
• Majok was one of several Cardinals who turned in impressive weeks statistically.
• Jauwan Scaife averaged 16.0 points over the two games and handed out a career-high seven assists Saturday at Miami. Chris Bond averaged 12.0 points, 5.5 rebounds and 4.5 steals per game. Jesse Berry averaged 14.5 points, and he knocked down a career-best six 3-pointers against Miami.
Majok's Dunk a Finalist for Play of the Year
• Majok Majok's buzzer-beating dunk to defeat Norfolk State on Jan. 2 won its round of fan voting last week to become a finalist for the GEICO Play of the Year.
• The play beat out three others last week and will be one of eight finalists up for the award in another round of fan voting in March at facebook.com/BestofCollegeBasketball. All eight finalists will appear on the Best of College Basketball show April 6 on CBS.
Staff Connections
• Two members of the Toledo coaching staff have strong Ball State connections.
• Toledo's associate head coach Angres Thorpe was an assistant at Ball State for two years from 2000-02 and was a part of the Cardinals' run to the finals of the 2001 Maui Invitational.
• Michael Bennett, the Rockets' director of basketball operations, played on Ball State's Maui team. He lettered from 2001-05 and spent last year on the Cardinals staff as video coordinator.
• Bennett and Ball State director of operations Mickey Hosier are brothers-in-law.
Balanced Scoring
• Ball State's three leading scorers -- Jauwan Scaife, Jesse Berry and Majok Majok -- have scored nearly the exact same number of points for the season.
• Berry and Majok have each scored 227 points, while Scaife has scored 220.
• The Cardinals are coming off one of their most balanced scoring games of the season at Miami, where Majok scored 21, Berry 20, Chris Bond 16 and Scaife 14.
Cleaning Up on the Glass
• Ball State has out-rebounded all six of its Mid-American Conference opponents.
• The Cardinals out-rebounded Eastern Michigan (29-16), Kent State (48-39), Akron (33-32), Central Michigan (37-34), Buffalo (33-30) and Miami (37-17).
• Ball State has out-rebounded its opponents by an average of 36.2 to 28.0 in league play for a +8.2 margin that leads the MAC.
• For the season, the Cardinals are +3.7 on the boards on average.
Mr. Double-Double
• Junior forward Majok Majok is one of 16 players in the nation averaging a double-double at 12.6 points and 10.1 rebounds per game.
• The last Cardinal to average a double-double in a season was Theron Smith, who tallied 19.6 points and 10.9 rebounds per game in 2001-02.
• Majok, who leads the MAC with seven double-doubles, is averaging a team-best 15.5 points and 9.3 rebounds per game in league play.
• With 18 points and 17 rebounds Dec. 5 against Holy Cross (Ind.), Majok became the first Ball State player since Cameron Echols in 2002 with at least 18 points and 17 rebounds in a game.
Majok on the Glass
• For the season, Majok Majok ranks 16th nationally and leads the Mid-American Conference at 10.1 rebounds per game. He averages nearly two rebounds more per game than his nearest competitor in the league rankings.
• Majok's 46 rebounds over Ball State's three games from Dec. 5 through Dec. 15 were the most in a three-game stretch by a Cardinal since Theron Smith grabbed 46 over three conference games from Jan. 5-12, 2002.
Scaife Moves into Second on Treys List
• With a pair of 3-pointers Saturday against Miami, senior guard Jauwan Scaife moved into solo possession of second place on Ball State's career 3-pointers list with 165.
• He surpassed Peyton Stovall (2003-08) for No. 2 on the list and now trails only Patrick Jackson (1998-2002), who holds the school record at 202.
• Junior guard Jesse Berry has also climbed into the top 10 on that list. He now owns 135 career 3-pointers to tie for eighth in school history. He is 20 treys away from cracking the top five.
Scaife Joins 1,000-Point Club
• With 17 points Jan. 16 at Akron, senior guard Jauwan Scaife surpassed the 1,000-point mark for his career. The local product from Muncie Central High School became the 26th member of Ball State's 1,000-point club. He now owns 1,048 points to rank 24th in school history.
Lineup Consistency
• Ball State has used the same starting lineup in every game but two this season: guards Jesse Berry and Jauwan Scaife, forwards Chris Bond and Majok Majok, and center Zach Fields.
• The only times the lineup varied were Jan. 19 at Central Michigan and Saturday at Miami when forward Matt Kamieniecki started in place of Fields.
Second-Half Improvement
• Ball State has been a better shooting team and a higher scoring team in the second half of games this season.
• The Cardinals are shooting 46.0 percent in the second half of games compared to 38.7 percent in the first half. BSU is scoring 33.9 points in the second half compared to 29.3 in the first.
• Ball State's interior players have been especially efficient over the final 20 minutes of games with Chris Bond shooting 57.7 percent, Majok Majok 56.2 percent and Zach Fields 55.2 percent in the second half of games.
High Volume Rebounding
• Junior forward Matt Kamieniecki is averaging 0.321 rebounds per minute, having grabbed 84 rebounds in 262 minutes, just behind Majok Majok (0.323) for the best average on the team.
• By comparison, Siena's O.D. Anosike, who leads the nation with 12.0 rebounds per game, is pulling down 0.317 boards per minute.
• Kamieniecki set a career-high with 10 rebounds in 24 minutes Jan. 19 at Central Michigan.
Scaife Picking up his Offense
• Senior guard Jauwan Scaife is averaging 15.6 points per game over the past eight contests after averaging 9.5 points over the first 10 games of the season.
• Included in that stretch is a season-high 21-point game against IUPUI, a trio of 18-point performances against Norfolk State, Eastern Michigan and Buffalo, and a 17-point effort versus Akron.
• After shooting 29.3 percent from the floor (27-for-92) and 20.0 percent from 3-point range (10-for-50) over the first 10 games, Scaife has knocked down 41.9 percent from the floor (39-for-93) and 38.6 percent from beyond the arc (22-for-57) over the past eight outings.
Bond Knows How to Finish
• Junior forward Chris Bond has earned a reputation as a finisher at the basket.
• The junior forward has connected on 52.5 percent of his career field goal attempts, which is on pace to rank seventh in school history.
• Bond matched his career high with 18 points in the MAC opener at Eastern Michigan and knocked down the game-winning free throws in the final second.
• He finished that game a perfect 8-for-8 from the floor, the most efficient shooting performance in the league this year, and is now shooting 58.3 percent in MAC games.
Bond Stealing the Show
• Chris Bond ranks first in the Mid-American Conference in steals with an average of 2.3 per game and first in league games only at 3.2 per game.
• Bond matched his career-high with five steals, all in the first half, Saturday at Miami.
• He has had seven games this year with at least four steals.
• Just 18 games into the season, Bond's 42 steals have already surpassed his previous career high of 29 steals as a sophomore last season.
Berry's Explosive Performances
• Junior guard Jesse Berry scored 20 points Saturday at Miami for his fifth 20-point game of the season and the seventh of his career.
• Berry, the MAC West Player of the Week twice this season and three times in his career, scored a career-best 28 points Nov. 28 against Cleveland State.
• He went for 22 in back-to-back games Dec. 15 at South Dakota and Dec. 18 at Purdue, and he scored 21 in the non-conference finale against Norfolk State.
Posley the Distributor
• Freshman guard Marcus Posley leads the Ball State guards with an average of 2.9 assists per game and a 1.89-to-1 assist/turnover ratio.
• Posley has reached five assists in five games this year, including a career-best six helpers without a turnover in the season-opening win over Grambling State.
• In all five of those games, Posley has had one turnover or fewer.
• He has had only four games all season with more than two turnovers.
Fields Gets Smaller to Play Bigger Role
• After four years in the program, fifth-year senior center Zach Fields made his first career start in the season opener against Grambling State and has gone on to start 16 of Ball State's 18 games.
• Fields made the most of the opportunity in the opener, logging career highs with 10 points and eight rebounds. His previous career bests were four points and four boards.
• He scored eight points in the MAC-opening win at Eastern Michigan and added nine more Jan. 19 at Central Michigan in one of only two games he has come off the bench.
• The 6-foot-10 Fields, who has lost 30 pounds in an effort to make a greater impact, is averaging 18.1 minutes per game this year after never logging more than 5.4 minutes per game previously.
Ramey Misses Time
• Freshman guard Michael Ramey has been out for the past seven games as he recovers from an illness suffered in December. Ramey played in 10 of the Cardinals' first 11 games and scored in double figures twice -- 11 points versus Wofford and 10 against Holy Cross (Ind.).
Thrilling Finishes
• Ball State won both its last non-conference game and its first MAC contest on its final possession.
• The Cardinals topped Norfolk State, 62-61, Jan. 2 when Jesse Berry drove the length of the floor with 6.3 seconds left and found Majok Majok for a buzzer-beating dunk.
• Jan. 9 at Eastern Michigan, Berry's pass went to Chris Bond, who drew a foul at the rim and made both free throws with less than one second left to lift the Cardinals to a 60-58 win.
Koch Back in Action
• Junior forward Tyler Koch is now 10 games into his return to the court after missing the first eight games of the season with a hand injury.
• Koch scored a season-high 10 points Dec. 23 against IUPUI.
• A former Wright State transfer, Koch started 22 games last year in his first season at Ball State. He scored 6.6 points and grabbed 3.3 rebounds per game.
One of the Best in the West
• Ball State has finished among the top three in the MAC West Division in each of the past four seasons, including first- or second-place finishes in three of those years.
• The Cardinals tied for the division crown in 2008-09 and finished second in both 2009-10 and 2010-11. Last year, Ball State tied for third in the West.
Returning Experience
• While Ball State returns only six letterwinners from a season ago, those six players have now combined to play in 423 games with 220 starts for the Cardinals.
• Senior guard Jauwan Scaife is the most experienced, having played in 108 games (81 starts).
• Junior guard Jesse Berry (80 games, 33 starts), junior forwards Chris Bond (76 games, 57 starts), Matt Kamieniecki (62 games, 13 starts) and Tyler Koch (37 games, 22 starts), and senior center Zach Fields (60 games, 16 starts) also have a wealth of experience in the Ball State program.
Welcome Freshmen
• Of the eight newcomers on Ball State's active roster, seven are true freshmen. Here is a breakdown of the freshman class by position ...
• Guard -- Marcus Posley (Rockford, Ill./Auburn HS), Michael Ramey (Indianapolis, Ind./Southport HS), Chase Brogna (Houston, Texas/St. Thomas HS) and George Cater (St. Peters, Mo./Fort Zumwalt South HS).
• Forward -- Bo Calhoun (South Bend, Ind./Washington HS) and Rocco Belcaster (Berwyn, Ill./Morton HS).
• Center -- Mading Thok (Boyden, Iowa/Western Christian HS).
• Ball State's only non-freshman newcomer is Majok Majok (Perth, Australia/Midland College).


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Brass knuckles
Tools and Technologies
Non-Firearm Weapons
> Brass knuckles
January 19, 2013, 01:09 PM
i would never use them but i enjoy collecting them. Id like to have a wwi trench kinfe and maybe a pair from the civil war
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January 19, 2013, 05:01 PM
Search is your friend
January 20, 2013, 08:13 AM
Him asking here is sort of searching, I don't get why some posts get dozens of well thought out answers even if it's been asked hundreds of times, then others are told to search for yourselfs, if you do not want to help why not ignore the post, And to The OP I know with a ccdw license in Florida you can carry them, used to be the same in Kentucky, but check in your state first, I like the looks of them and own a few but would not use for defense too up close and bloody, I prefer to keep as much distance as possible between me and a attacker,, and if that close is unavoidable I'd use my cane or knife...
January 20, 2013, 03:31 PM
Where exactly was the question? Just saying be would like so and so does t leave much room for discussion.
January 22, 2013, 12:49 AM
i was just seeing if anyone else enjoys collecting them as much as i do. i agree they are not much useful today but more of a weapon from a by gone era
Il Duca
January 22, 2013, 04:29 PM
Actually brass knuckles/knuckle dusters/whatever you want to call them are outlawed in FL. Carrying, posessing, making, buying and selling are all illegal. Only reason I don't own any.
Otherwise, I would enjoy owning and collecting them.
January 22, 2013, 04:32 PM
SenecaGunner, for antique brass knuckles and WWI trench knives I would try yard sales, flea markets, and as a last option the Internet. You may also want to add blackjacks to you collecting interests.
Understand that most areas will not allow you to carry any of the above in public and some areas don't even allow ownership of these items.
Sadly, Its' become somewhat of an us against them mentality with L/E and the citizens they swore to protect. I would know about any restrictions in the area you live before you acquire any of the items you are interested in.
P.s. my last paragraph is not meant as cop bashing, as I spent 27 years on the job, retiring in July of 2001.
January 22, 2013, 07:29 PM
Illegal here in MI, too.
January 23, 2013, 08:48 PM
I wish we could carry them with our CCW.
February 5, 2013, 04:03 PM
If you cannot legally posesses and carry brass knuckles, would carrying a roll of quarters help? Not aware of any legal restrictions .
February 5, 2013, 04:33 PM
Comtech stinger
February 6, 2013, 12:46 PM
i would never use them but i enjoy collecting them. Id like to have a wwi trench kinfe and maybe a pair from the civil war
I'm rather facinated by many specialized impact weapons; brass knuckles, saps., yawara sticks, etc. Most of them are the very least illigal to carry most places, but I think they are still interesting and I have a few "collectables" in a drawer at home.
Dr. Sandman
February 14, 2013, 12:49 PM
Outfits like BudK and Kennesaw (the same company?) sell both the freestanding brass knuckles and replicas of the WWI trench knife. You could have a set for about $25-30 bucks if I recall. I think they are selling the brass knuckles as paperweights. You don't want your papers blowing around, do you?
February 14, 2013, 01:38 PM
My last use for Brass Knucks was for installing antennas. No Really. I was playing with long wire and home built coathanger constructed antenna for Ham radio use and needed to get them up off the ground. I was using a set of knucks on the end of a heavy cord as a throwing weight. In the service we had used a lifting ring/ fuse well plug from a 155 mm gun/howitzer HE round for this, but the Knucks were what I had at home. They became tangled in a tree in my yard and I lost them trying to pull them back down. Over a two year period the tangled cord rotted and the sping following the second winter I found the knucks......with my lawn mower. Excitement. Very bad for knucks and mower blades.
CA Raider
February 26, 2013, 11:13 PM
"i would never use them but i enjoy collecting them"
well I guess you're a gentleman. and I mean that sincerely.
but in some of the cra**y places I go to - I wouldn't hesitate to use them. It's better to make the other guy hurt. It beats winding up with broken fingers on your own hands, or worse still in the emergency room. They're generally illegal in a lot of places in the USA. But you can usually improvise something that has the same effects.
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INWOOD -Police said they are awaiting the results of forensic tests before confirming the identity of a driver who died in a fiery crash Tuesday on Interstate 81 as an apparent result of driving the wrong way on the highway near Inwood.
The two-vehicle accident occurred at 2:14 a.m. on I-81 North near Exit 5, police said.
"We're waiting for official word. We feel like we know who it is, but before we release it we have to be sure. That's kind of where we are, awaiting positive identification," Berkeley County Sheriff Kenneth "Kenny" Lemaster Jr. said Tuesday.
Article Photos
Submitted photo
A two-vehicle accident occurred at 2:14 a.m. on I-81 North near Exit 5. Both vehicles were engulfed in flames when officers arrived on the scene.
The accident involved a tractor-trailer and a 2005 Ford Explorer sports utility vehicle, according to a press release issued by the Berkeley County Sheriff's Department.
A preliminary investigation and statements from witnesses at the scene suggest the driver of the Explorer was traveling southbound in the northbound left lane of I-81 when the SUV collided with the tractor-trailer, the release said.
Both vehicles were engulfed in flames when officers arrived on the scene. The driver and passenger of the tractor-trailer were able to exit their vehicle. The driver of the Explorer was trapped inside the SUV and was pronounced dead at the scene.
Lemaster said it's not clear yet why the driver of the SUV was traveling the wrong way on the highway.
"Not until we have some forensic information and things like that," Lemaster said.
He said the driver's remains would be sent to the West Virginia Medical Examiner's Office for an autopsy. Northbound lanes of I-81 remained shut down for more than six hours after the accident, Lemaster said.
The Berkeley County Sheriff's Department is asking anyone who witnessed the accident or who has information on the crash to contact Deputy P.D. Ware at 304-267-7000, or the Berkeley County Crime Solvers at 304-267-4999.
-Staff writer Edward Marshall can be reached at 304-263-8931, ext. 182.


text:
Source: All Things D
quote: Once you own any one of Apple's product line....you HAVE to use Itunes. There are no other choices in that ecosystem for all within its collective...unless you hack your IProduct. Read Apples Terms of Agreement (TOA) and you will learn they can cancel your account and delete all your content with no further responsibility to you. Google does not force/require you to use their market place or any proprietary software. They provide YOU with the power to uncheck an option that will then allow you to purchase from other market places. Try that with Apple. YOU CAN'T.


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on April 18, 2013 - 1:47 AM
, updated April 18, 2013 at 2:31 AM
We cannot tell you what was inside the head of the bomber who killed three people and wounded at least 170 more at the Boston Marathon this week.
But we can tell you what was in the head of Timothy J. McVeigh, who 18 years ago this Friday bombed a federal office building in Oklahoma City, killing 168 people, including 19 children, and wounding more than 500 others.
McVeigh was proud of his bombing. He hated the United States government and considered it "the biggest bully in the world."
He wanted people all over the world to know what he did and why he did it. He even wore a T-shirt celebrating terrorism on April 19, 1995, and carried a stack of anti-government documents in his getaway car.
The Boston Marathon bomber, or bombers, walked into a crowd of thousands of innocent people and planted two bombs designed to kill, maim and get the attention of a horrified nation.
We do know that the choice of target was a very public event a few days short of the anniversary of McVeigh's horrific attack.
The 7,000-pound truck bomb McVeigh ignited was thousands of times more powerful than the two "pressure cooker" bombs used at the marathon. McVeigh lit a fuse, parked the truck and ran away from the vehicle. His actions that day forever changed America's way of life. McVeigh, a decorated Persian Gulf War veteran from rural Niagara County, had turned against us.
Beyond the agony over the deaths of an 8-year-old boy and two other innocent people, beyond the powerful reminder of our collective vulnerability, the Boston Marathon bombing raises a lot of questions:
• Was the bomber an outsider who hated America, or a homegrown terrorist like McVeigh?
• What were his or her motivations?
• Did the bomber despise America's way of life, its freedoms or its government policies, as McVeigh did?
• Did the bomber intentionally leave clues, as McVeigh did?
• Does the bomber plan to commit other acts of terror?
We don't have those answers, but we can tell you what we learned from McVeigh during more than 70 hours of interviews and many phone calls and letters, during the research for our 2001 book, "American Terrorist."
Even though millions of Americans despised him for it, McVeigh was convinced he was doing the right thing when he set off the bomb. In fact, he was disappointed that his bomb took down "only" half of the nine-story Alfred P. Murrah Federal Office Building.
More importantly, how did McVeigh, or any bomber of innocent people, justify such an act?
When asked about the deaths of innocent people, including young children in the Murrah Building's day care center, McVeigh called those deaths "collateral damage."
"To these people in Oklahoma who have lost a loved one, I'm sorry, but it happens every day," McVeigh responded, showing absolutely no compassion for his victims.
Is that what the Boston Marathon bomber thinks?
McVeigh chose a government building hoping to kill government employees. This bomber targeted an athletic event attended by average citizens on Patriots Day.
McVeigh hoped that the American people would someday consider him a hero for striking back at the U.S. government, an entity he blamed for unfair laws, particularly against gun owners, and for acts of aggression all over the world.
This week's bomber has not yet provided a motive.
Although McVeigh was arrested just hours after the bombing, he took six years to publicly confess what he had done, in our book. But he did leave all kinds of helpful clues for investigators on the very day of the bombing. He wore a T-shirt that celebrated the assassination of President Abraham Lincoln with the message "The tree of liberty must be refreshed from time to time with the blood of patriots and tyrants," words that Thomas Jefferson wrote shortly after the American Revolution.
In his getaway car, McVeigh left a treasure-trove for investigators – a large envelope packed with articles explaining why he despised the U.S. government, including its handling of the confrontation in Waco, Texas, with the Branch Davidian sect in which 82 members reportedly were killed, including 76 in a deadly fire April 19, 1993, that ended a 51-day standoff.
The documents also included a piece of paper with quotes from "The Turner Diaries," the fictional account of Earl Turner, a domestic terrorist who blew up a government building in Washington, D.C.
"The real value of our attacks today lies in the psychological impact, not the immediate casualties," Turner proclaims in the passage copied by McVeigh. "More important, though, is what we taught the politicians and the bureaucrats. They learned this afternoon that not one of them is beyond our reach."
Investigators in Boston say they are making progress, but have not given any details.
McVeigh also had what could be called petty beefs with the government.
Soon after leaving the Army, the Bronze Star recipient received a notice from the Department of Defense for repayment of $1,058 that it said he had been overpaid:
"Go ahead, take everything I own; take my dignity," McVeigh said in response. "Feel good as you grow fat and rich at my expense; sucking my tax dollars and property, tax dollars which justify your existence and pay your federal salary. Do you get it? By doing your evil job, you put me out of work."
McVeigh later told us he knew that the Army had overpaid him but felt justified in receiving the money because of the sacrifices he had made during his service. He also was upset over the divorce of his parents. And in boyhood, he had come to hate bullies, once having his head pushed into a toilet at school by two older students who held him upside down for what McVeigh described as a "swirlie."
That anger in time morphed into a massive hatred toward what he called the "federal juggernaut" and its law enforcement agents. The deadly August 1992 shootout at the Ruby Ridge, Idaho, cabin of Randy Weaver outraged him. He also visited Waco during the siege there.
He openly expressed his views a few miles from the Branch Davidian compound, selling bumper stickers that stated "WHEN GUNS ARE OUTLAWED, I WILL BECOME AN OUTLAW" and "FEAR THE GOVERNMENT THAT FEARS YOUR GUN."
Was this week's bomber trying to send some type of message about constitutional freedoms by selecting Boston, considered the birthplace of the American Revolution?
On June 11, 2001, McVeigh was executed by his enemy, the U.S. government. He never got his wish to go down in the history books as a hero.
He remains a terrorist, despised by millions.
email: email@example.com and email@example.com


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Lot # 984 (of 1411) < Previous Lot | Next Lot >
1913 Barnum & Bailey "Famous Elephant Base-Ball Team" Circus Poster
Starting Bid - $1,000.00, Sold For - $3,770.00
Extremely rare Barnum & Bailey circus poster heralding the appearance of "Mooney's Giants-The Famous Elephant Base-Ball Team." The colorful half-sheet poster (30 x 20 inches) features an extraordinary illustration of the talented pachyderms playing baseball, complete with a fully equipped catcher and umpire. Copyright 1913 by the Strobridge Litho Company of Cincinnati and New York. This is one of the rarest of all circus posters, and also one of the most delightful, fun, and interesting baseball-related display pieces ever produced. Featuring exceptional graphics, this poster generates positive attention and a positive emotional reaction in an across-the-board manner that few display pieces of any kind (baseball-related or otherwise) can match. The only other example of this poster we have ever seen appeared as the cover lot in Robert Edward Auctions' June 1996 auction. That example was purchased by special request specifically for donation to the Hall of Fame, and is now on display in Cooperstown as part of the Hall of Fame's permanent collection. Since the 1996 auction, no other examples have surfaced. This is, in fact, only the second example of this poster we have ever seen at auction anywhere ever. The poster has been linen-backed and has benefitted from professional restoration. Both of those process have effectively addressed many of its minor flaws, so that the poster now presents an Excellent overall appearance. This is an outstanding display piece with a rare universal appeal. Reserve $1,000. Estimate $2,000/$4,000. SOLD FOR $3,770.00
(Click the smaller thumbnails to the left and right (if any) to cycle through each photo in the gallery of images for this lot.)


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|P-Glycoprotein Structure and Chemotherapy Resistance
A research team from the Scripps Research Institute and the Texas Tech University Health Sciences Center has obtained the first glimpse of a protein that keeps certain substances, including many drugs, out of cells. The protein, called P-glycoprotein, or P-gp for short, is one of the main reasons cancer cells are resistant to chemotherapy drugs. Understanding its structure may help scientists design more effective drugs. The structure is a nice tool for understanding how drugs are transported out of cells by P-gp and for designing drugs to evade P-gp, preventing drug resistance.
P-gp, a protein first identified in 1976, sits in the membrane that surrounds human cells, including those in the gut, intestine, kidney, and brain, where it functions as a gate keeper, shooing out potentially harmful agents. Problematically, P-gp not only transports substances that are harmful out of the cell, but also drugs targeted to cancer cells and HIV-infected cells, as well as some therapeutics aimed at alleviating psychiatric conditions.
The scientists succeeded in performing the x-ray crystallography on mouse protein P-gp at SSRL, APS, and ALS Beamlines 8.2.2 and 8.3.1. Once they solved the structure, they found that the mouse P-gp, which is 87 percent identical to its human counterpart, has the shape of an upside down "V" or an inverted cone with a large cavity inside. The cone's interior is lined with amino acids that bind to various substances, holding them in place. The top part of the cone resides inside the cell membrane and has two openings for substances to enter; the bottom portion protrudes into the cell, ending in two dumbbell-shaped arms.
This overall shape is strikingly similar to that of another protein, MsbA, that transports lipids out of bacteria (see previous ALS highlight, "Protein Flips Lipids Across Membranes"). This similarity suggests that P-gp works by bringing the two dumbbell-shaped arms together on the inside of the cell and opening the closed end toward the outside of the cell, essentially reversing direction of the "v" shape so any substance caught inside the protein's cavity is ejected from the cell.
While the new study shows another similarity between bacterial MsbA and mammalian P-gp—both binding cavities are lined with hydrophobic (water-avoiding) amino acids—it turns out that the mammalian P-gp has many more such amino acids and a greater variety of them, including ones containing aromatic compounds (i.e., compounds with one or more benzene rings). The presence of so many hydrophobic and aromatic residues explains how, unlike the bacterial protein, the mammalian P-gp is able to accommodate a wide range of substrates.
This study also produced insights by showing structures of P-gp bound to some of its substrates. Research team members Chang and Aller collaborated with Qinghai Zhang, an assistant professor at Scripps Research who had designed several compounds that can block the function of P-gp. These compounds bind inside the P-gp cavity, preventing other substances from entering. Chang and Aller were able to obtain the structures of two of Zhang's compounds inside P-gp. They both go in the same cavity and bind to different amino acids, but with some overlap. What this tells us is that there is an extremely important core set of amino acids in P-gp that bind all substances, and there are additional amino acids for fine-tuning the binding to specific drugs.
Knowing what the P-gp binding cavity looks like and precisely where substances bind may allow researchers design better drugs, for example by using chemistry to modify portions of that drug so that it can sneak past P-gp to get inside cells. One advantage in this process is that we don't have to design brand new drugs, but rather redesign existing ones to make them work better.
Research conducted by S.G. Aller, J. Yu, A. Ward, Y. Weng, S. Chittaboina, Q. Zhang, and G. Chang (The Scripps Research Institute); R. Zhuo, P.M. Harrell, Y.T. Trinh, and I.L. Urbatsch (Texas Tech University Health Sciences Center).
Research funding: U.S. Army, National Institutes of Health, Beckman Foundation, Skaggs Chemical Biology Foundation, Jasper L. and Jack Denton Wilson Foundation, Southwest Cancer and Treatment Center, and the Norton B. Gilula Fellowship. Operation of the ALS is supported by the U.S. Department of Energy, Office of Basic Energy Sciences.
Publication about this research: S.G. Aller, J. Yu, A. Ward, Y. Weng, S. Chittaboina, R. Zhuo, P.M. Harrell, Y.T. Trinh, Q. Zhang, I.L. Urbatsch, and G. Chang, "Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding," Science 323, 1718 (2009).
ALSNews Vol. 298, May 27, 2009
More ALS Science


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quote: "The war against working people should be understood to be a real war.... Specifically in the U.S., which happens to have a highly class-conscious business class.... And they have long seen themselves as fighting a bitter class war, except they don't want anybody else to know about it."-- Noam Chomsky
quote: "Do as I say, not as I do"
quote: Its better to waste your time on him, then siting in front of the TV and waste time like that like a zombie.
quote: Hear the message not the man! Start to think for your self, and don't let FOX news ore so do it for you.


text:
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A thought for all of those hoping Holland will trade for a #1 defenceman:
Going over Ken Holland's moves, I noticed that he has only traded two regular roster players (i.e. players that have played at least 82 games for the Red Wings) since 2002. He traded Jamie Rivers in 2006 and Shawn Matthias in 2007. Not exactly blockbusters.
He has not traded a regular player in almost six years.
1. Why do you think he has chosen this strategy?
2. Do you think the strategy will change now that Lidstrom is retired?
Ref: List of all of Ken Holland's moves.


text: The Confiserie Steinmann has three outlets in Kyburgstadt Thun. Here you will find everything your heart desires. The quality of the products is not only due to our sophisticated recipes using the finest ingredients; it also reflects the high levels of motivation on the part of our employees. Our guests may enjoy our original coffee creations, a range of sweets, as well as lunch menus in the tea room.