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Tuesday, July 9, 2013
Volunteers and fans of the Island Realty Vacations Rentals Facebook page got together on July 4 for the "Salute From the Shore" annual event, commemorating the men and women of the United States military. Fighter jets fly over the shorelines of the southeast coast.
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NSCLC is "Major Battlefield" as Merck,...
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President Obama's proposed $3.8 trillion budget for the 2014 federal fiscal year offers small overall increases for NIH and FDA, but sizeable jumps in programs reflecting the administration's biopharma priorities.
Obama is seeking $31.331 billion in overall program level funding for NIH, up just 1.5% from the $30.852 billion spent during FY 2012. However, the NIH spending plan would deliver a 14% increase in the number of "new and competing" research project grants, a nearly 16% jump in spending on NIH's translational medicine center, a 4% rise in stipends for postdoctoral trainees, and new spending on Alzheimer's disease and brain mapping.
NIH said it planned to award 36,610 research project grants in FY 2014 costing $16.932 billion, just 351 more grants (and 2% in dollars) than FY 2012. The grants number includes 10,269 new and competing grants, 1,283 more than two years ago. The cost of new-and-competing grants will zoom almost 24% or $902.958 million, to $4.685 billion.
Another double-digit increase is in store for NIH's National Center to Advance Translational Science (NCATS). The center—launched two years ago by NIH Director Francis S. Collins, M.D., Ph.D.—would see funding jump almost 16% from FY 2012 (and 4% from Obama's still-pending FY 2013 budget proposal), to $665.688 million. Within NCATS, the Cures Acceleration Network, created to fund programs addressing scientific and technical challenges of translational research, would grow to $50 million from the current $40 million.
Obama's budget would raise stipends for entry-level postdoctoral trainees and fellows to $42,000, with 4% increases for each subsequent level of experience. The increase would be part of the National Research Service Awards program, whose funding will rise 1.8% from FY 2012, to $775.975 million—though the number of trainees supported would dip by 108, to 16,197.
Decreasing as well, by 6.4%, would be research center grant funding, to $2.846 billion. However, NIH shifted about $67.9 million of the $194.5 million difference to its National Institute of Allergy and Infectious Diseases (NIAID), toward grants to establish multi-project translational research centers in biodefense and emerging infectious diseases research. Another $51.3 million of the drop reflected planned reductions within the Protein Capture, Human Microbiome, Molecular Libraries, and Bioinformatics and Computational Biology programs.
The budget also formalized previously announced new spending on priority programs: $40 million for the brain mapping initiative announced by Obama on April 2, and $100 million to expand Alzheimer's disease research, for which NIH has estimated it will spend $562 million on research.
While FDA would enjoy a 21% bigger budget in FY 2014 under Obama's plan, most—but not all—of that increase reflects previously enacted hikes in user fees paid by developers of drugs and other products regulated by the agency.
FDA would see its total budget balloon to $4.8 billion, though its budget authority would increase only 2% or $51.884 million, to $2.558 billion. The remainder of the agency's 21% hike would come from user fees that exceed levels enacted into law by Obama just last July in the FDA Safety and Innovation Act (FDASIA).
FDASIA includes the fifth five-year authorization of the Prescription Drug User Fee Act, under which Washington anticipated collecting $720 million in prescription-drug user fees, and expanded the user-fee program to generic drugs (about $299 million anticipated) and biosimilar drugs (just over $20 million).
But in his FY 2014 budget proposal, Obama called instead for $760 million in prescription-drug user fees, up 5.5% from FDASIA; $305.996 million for generics user fees, up almost $7 million; and $20.716 million in biosimilar user fees, up about $500,000.
In 2014, user fees would account for 45% of FDA's total budget, up from 35% in FY 2012. That percentage swells to nearly two-thirds (63.9%) of the $1.292 billion spent on human drugs programs, up from 50% two years earlier.
Also rising would be the number of employees whose jobs would be paid through user fees. The number of full-time equivalent employees funded through prescription drug user fees would increase by 72, to 2,778. The budget also envisions 690 employees funded through generic drug user fees, and 72 through biosimilar user fees.
No generic or biosimilar fees were collected in FY 2012. Those fees, FDA says, will help pay for it to adopt a pathway for approving biosimilars and biologic drugs. Obama's budget also revived his earlier plan to cut the exclusivity period for biologics from 12 to seven years—a proposal defeated in past years through industry opposition.
FDA's program priorities in 2014 include:
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COLUMBIA — A steady breeze blew through Carolina Stadium most of Sunday afternoon, flapping the three flags in right center field in toward home plate, and then out toward left field. This was, by and large, not a power hitter's day.
Then Joey Pankake led off the fourth inning with a single, and South Carolina's best slugger, LB Dantzler, approached the plate — a prime chance for South Carolina to score its first run as it aimed to finish a sweep of Kentucky. USC coach Chad Holbrook stood in the dugout, pondering the situation. He looked at the flags. They were limp.
"Boy, it would be good for him to get one in the air right now," Holbrook thought.
Dantzler faced an 0-1 count against starter Corey Littrell, and Dantzler anticipated a fastball for the second pitch. Littrell threw a cut fastball or slider, and left it up in the strike zone. But even as Dantzler crushed the pitch to center field and ran down the first base line, he thought, "Dang it. Just a long flyout." He had already seen how Kentucky's best hitter, A.J. Reed, smacked balls to the outfield, only for the wind to deny them.
"I didn't think it had a chance of going out," Dantzler said later.
Yet for this moment, on a weekend of good fortune for USC, the wind relented and the ball kept carrying until it cleared the wall in dead center and landed an estimated 410 feet from home plate. Max Schrock stood in the on-deck circle, watched it disappear and said aloud, "Wow."
The two-run homer was all the pop USC needed to beat Kentucky, 3-1, on a day when USC's freshman starter, Jack Wynkoop, announced himself as a fixture in the rotation henceforth. Dantzler's swing put the Gamecocks up 2-1, and Holbrook couldn't help but consider it symbolic of the weekend. He couldn't help but notice something else, too.
"As soon as he touched home plate, the wind started blowing again," Holbrook said.
Just as the 18th-ranked Gamecocks (31-10, 11-7 Southeastern Conference) responded to getting swept by Arkansas with sweeps the next two weekends, they answered last weekend's sweep of losses at Florida with three straight wins over No. 17 Kentucky.
Five straight weekends, five sweeps, three in their favor, and with four of their 10 SEC series remaining, the Gamecocks have refused to wilt because of early hitting struggles and important injuries. They will learn much more about themselves next weekend when they travel to No. 3 LSU, and the following weekend when they host No. 2 Vanderbilt. Those teams' SEC records: 15-3 and 16-2.
This much the Gamecocks already know: They can hit as well as they expected to. They hit .172 in their first two SEC series. In their next four, they have batted .309. Dantzler, who hit .262 last season, is having a remarkable senior year: a .331 batting average, 1.113 on-base plus slugging percentage, 12 homers and 42 RBIs. Since 2009, no Gamecock has hit more than 13 homers in a season. Last year, Christian Walker led USC with 11 homers and 55 RBIs.
Though USC has seen left fielder Graham Saiko, center fielder Tanner English, ace pitcher Jordan Montgomery and closer Tyler Webb all miss time with injuries, the Gamecocks' best hitters — Dantzler, Pankake and Grayson Greiner — have remained healthy, and all emerged from the early sputtering with plus-.300 batting averages.
"There was never a point in time where we really doubted ourselves," said Schrock, whose 30 RBIs are tied with Pankake for second on the team. "When a lot of guys were 'struggling,' they were still hitting balls hard. They were just hitting them right at people. Maybe the numbers weren't there, but I think we were all still squaring balls up."
Things are also beginning to brighten for USC's starting pitching, which floundered at times during Montgomery's month-long absence with an elbow bone stress reaction. If the rotation of Nolan Belcher, Montgomery and Wynkoop mimics its performance against Kentucky, the Gamecocks will challenge for series wins against LSU and Vanderbilt.
In eight innings Sunday, Wynkoop allowed nine hits (eight singles) and one unearned run, while starting for the first time since March 30. He walked nobody, struck out three, and 75 of his 100 pitches were strikes. Webb on Sunday threw a scoreless ninth with two strikeouts after returning Saturday from a two-week absence due to an elbow muscle strain. For the weekend, USC's starters totaled 211/3 innings, 16 strikeouts and two walks, and had a 1.69 ERA.
There were no grand milestones for USC this weekend, though Montgomery did start at home for the first time since Feb. 23 and Wynkoop got his first SEC win in his third league start. He did not keep a game ball, and didn't need to. The weekend's progress is valuable enough.
"It's going to give me some confidence coming into the rest of the year," Wynkoop said. "And I'll definitely remember this day."


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Cross Country Top Times: 5K - 18:08.7 (10/5/12) / 6K - 22:09 (11/9/12)
Indoor Track & Field Top Times: 800m- 2:14.29 (2/15/13) / Mile - 4:50.10 (2/22/13) / 3000m - 9:54.44 (2/8/13) / 5000m - 17:40.89 (1/18/13)
Outdoor Track & Field Top Times: 200m - 29.50 (3/26/11) / 800m - 2:15.46 (4/21/12) / 1500m - 4:33.39 (5/10/12) / 5000m - 17:52.67 (5/13/11) / 3000m Steeplechase - 12:18.65 (4/16/10)
2012 CROSS COUNTRY (Sr.): Academic All-Mid-American Conference... led the Cardinals in all seven meets ... recorded a career-fast 5K time of 18:08.7 to win the Ball State Invitational (Oct. 5) ... placed second at the 5K IPFW Invitational (Sept. 14) with a clocking of 18:33.85 ... earned a 29th-place finish at the 6K MAC Championship (Oct. 27) with a time of 22:29.0 ... logged a career-best 6K time of 22:09 to place 93rd at the Great Lakes Regional (Nov. 9).
2012 OUTDOOR TRACK & FIELD (Jr.): Competed in eight meets ... placed eighth in the 1500m run at the Mid-American Conference Championships (May 10-12) with a finals time of 4:38:02 ... turned in a career-fast time of 4:33.39 in the prelims of the race ... also clocked a season-best time of 18:10.71 in the 5000m run at the MAC Championships ... won the 1500m run four times over the course of the season; 22nd Annual IWU Polar Bear Invitational (March 24), Bowling Green (April 14), Miami RedHawk Invitational (April 28) and the Jack Shaw Classic (May 4) ... earned a career-best 800m run time of 2:15.46 at the Polytan Invitational (April 21).
2012 INDOOR TRACK & FIELD (Jr.): Competed in seven meets ... ran anchor for the distance medley relay which placed eighth at the MAC Championships (Feb. 24-25) with a time of 11:58.18 ... placed 10th in the mile at the league meet with a career-fast clocking of 4:57.60 ... won the mile run at the Ball State Quadrangular (Feb. 17) with a time of 5:05.49 ... placed second in the 3000m run at the IWU Invitational (Jan. 28) with a career-best time of 10:26.89 ... opened the season with a second-place run of 5:06.80 in the mile run at the Bowling Green Opener (Jan. 14).
2011 CROSS COUNTRY (Jr.): Academic All-MAC ... led the Cardinals in all six meets ... posted BSU's first sub-19 minute 5K run of the season at the Indiana Intercollegiates (Sept. 16), and followed with a season-fast 5K clocking of 18:30.6 at the Greater Louisville Classic (Oct. 1) ... placed 32nd overall at the Mid-American Conference Championships with a season-fast 6K time of 22:16.3 ... turned in a solid 6K time of 22:26.0 to place 90th at the Great Lakes Regional (Nov. 12).
2011 OUTDOOR TRACK & FIELD (So.): Competed in six meets ... paced the Cardinals in the 5,000m run with a career-best finish of 17:52.67 at the MAC Championships (May 12-14) ... her season-best clocking of 4:37.39 in the 1,500m run at the Stan Lyons Invitational (April 30) was also the best individual effort on the squad during the season ... turned in a career-fast clocking of 29.50 in the 200m dash at the Polar Bear Invitational (March 26).
2011 INDOOR TRACK & FIELD (So.): Competed in seven meets ... led the Cardinals in the mile run with a season-best effort of 5:02.94 at the Hoosier Hills Invitational (Feb. 11-12) ... posted the second-best individual effort on the team in the 3,000m run with a season-best clocking of 10:56.19 at the MAC Indoor Championships (Feb. 25-26) ... helped the distance medley relay post a time of 12:26.97 capture first place at the Indiana Wesleyan Invitational (Jan. 29).
2010 CROSS COUNTRY (So.): Competed in six of BSU's seven meets ... crossed the finish line with a season-fast 5K time of 19:10.80 at the Indiana Intercollegiates (Sept. 17) ... added a season-best 6K time of 23:32.7 to place fourth among BSU runners and 70th overall at the MAC Championships (Oct. 30).
2010 OUTDOOR TRACK & FIELD (Fr.): Competed in five meets ... led Ball State with a season-fast clocking of 2:18.49 in the 800m run at the Stan Lyons Invitational (April 24) ... her clocking of 4:46.23 in the 1,500m run at the Pacesetter Invitational (May 1) was also BSU's top individual performance of the season ... turned in a career-fast time of 12:18.65 in the 3000m steeplechase at the Lenny Lyle / Clarke Wood Invitational (April 16).
2010 INDOOR TRACK & FIELD (Fr.): Competed in seven meets ... anchored the Cardinals' distance medley relay which placed eighth at the MAC Championships (Feb. 26-27) with a time of 12:08.42 to earn one point ... posted the Cardinals' second-fastest individual time in the mile run with a clocking of 5:06.61 at the Meyo Invitational (Feb. 4-6) ... her time of 18:41.63 in the 5,000m run at the Gladstein Invitational (Jan. 22-23) was also the second-best individual effort for a BSU runner during the season ... clocked in at 11:13.73 in the 3,000m run at the BGSU Challenge (Jan. 16) to rank third on the team ... won the mile run at the Indiana Wesleyan Invitational (Jan. 30) by crossing the finish line in 5:16.17.
2009 CROSS COUNTRY (Fr.): Competed in all five meets ... posted a season-fast 5K time of 20:01 at the Notre Dame Invitational (Oct. 2) ... clocked a season-best 6K time of 25:21.7 at the Sam Bell Invitational (Oct. 17) ... BSU's third-best runner at the weather-shortened 3K Ohio University Invitational (Sept. 26) with a time of 11:36.10.
HIGH SCHOOL: Four-year letterwinner in track & field and three-year letterwinner in cross country at Michigan City ... named Third Team All-State and All-Conference twice in cross country ... utilized a career-fast 5K time of 19:03 to place 33rd at the 2008 Indiana state meet ... earned all-conference honors in the 1,600m run in 2008 ... owns career-best in the 800 (2:22), 1,600 (5:08) and 3,200 (11:13).PERSONAL: Daughter of John and Beth Mellen ... full name is Mary Kathryn Mellen ... has two brothers, Max and Jacob, and one sister, Jordon ... born May 20, 1990, in Michigan City, Ind. ... majoring in telecommunications.
|Cross Country
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Fans asked to bring food items to game
WELLSVILLE - The Wellsville Touchdown Club asks that anyone attending Friday's football game with McDonald to bring a non-perishable food donation. The Harvest House of Wellsville will be collecting the food at the gates. Fans are asked to help those in need as the holiday seasons approach.
Basketball league meeting being held
GLENMOOR - The George Jones Youth Basketball League, formerly the East Liverpool Youyth Christian Basketball League, will be holding a meeting at 10 a.m. Saturday at the Glenmoor Presbyterian Church. Any church wishing to participate is asked to send a represenative to the meeting. For information, call 330-383-9192.
EL Rebound Club pasta dinner Friday
EAST LIVERPOOL - The East Liverpool Rebound Club will host a pasta dinner fundraiser from 5-7 p.m. Friday in the Westgate cafeteria before the East Liverpool-Oak Glen football game. Cost is $6 and includes pasta, salad, roll, dessert and drink. Carryout is available. Proceeds benefit ELHS boys basketball program.
Registration set for Seacats swim team
STRATTON - Stratton Seacats winter swim team sign ups will be held from 6-7 p.m. Friday and Oct. 26 at the Stratton indoor pool. Bring swim suit for swim test, insurance and emergency contact information with you. Ages 5 up to age 18 are welcome to participate. The cost is $20 for 1st child and $10 for each additional child in family. For information call Jenn at 740-317-9837.
Ups for Downs golf scramble to be held
CALCUTTA - A golf scramble to benefit the locally-based "The Ups for Downs" will take place Sunday at Turkana Golf Course. Cost is $240 per team of four ($60 per person). It's an 8 a.m. shotgun start. Money due as soon as possible prior to the event. Hole sponsors also are needed at a cost of $50 per hole. Those wishing to enter a team and sponsor a hole, the cost is $280. Doughnuts provided morning of the event, hot dogs at the turn, and hot dogs and hamburgers following the event. There will be prizes for closest to the pin, longest drive and longest putt, and well as monetary prizes to the top three teams based on entries. Mulligans and skins also will be sold, and a 50-50 will take place. Further information is available by contacting Eric Derrington at 330-383-1821. "The Ups for Downs" is part of the Tri-State Down Syndrome Support Group.
WVU-Michigan basketball in NYC
NEW YORK CITY - There will be a trip to New York City, open to the public, during the Dec. 15-16 weekend. The package will include charter transportation, overnight accommodations, breakfast at the hotel, and a ticket to the West Virginia vs. Michigan men's basketball game, to be played at the brand new Barclays Center. The trip will provide plenty of free time in NYC. The cost per person, based upon quad occupancy, is $192. Packages are also available for triple and double occupancy, as well as for those not wishing to attend the basketball game. All proceeds from the trip will benefit the Oak Glen Middle School Culture Club. For information, call 304-374-7474.
Dash to Mat's Bash being held Saturday
WELLSVILLE - Preparations are being made for the fourth annual "Dash to Mat's Bash" by the Mathugh Johnston Memorial Corp. and Ohio Valley College of Technology. The 1.5 mile fun walk/run, set for Saturday is a costume-based event through the village of Wellsville, taking in scenic Riverside Avenue, beginning at the Wellsville Municipal Building on Main Street. This year the race will be in memory of the late Vickie McCombs. The race will encompass Main, Ninth, and Fifth streets, and on race days those roads will be closed for approximately one hour. Race registrations can be found at "Dash for Mat's Bash" Facebook page, requested via email at email@example.com, or local businesses. Cost $10 per person and includes race packet, T-shirt, and entry for door prizes. Add $1 per size above XL. A kid's dash costs $5 will consist of a t-shirt, Halloween costume contest, candy bag, and other prizes. The third Fire Department Brigade Relay also will take place. The relay brigade will include six member teams, each running 400 meters for a total of the same 1.5 miles as the other participants. Each brigade of six members in Turnout Gear will hand off a water nozzle to the next participant until completion. Packet and t-shirt pick-up and late registration will be the day of the race beginning at 10:30 a.m. Late registration accepted until 1:45 p.m. at the municipal building. The kid's dash will start at 2 p.m. promptly followed with the 1.5 mile run/walk.
Wellsville painted Tiger paws for sale
WELLSVILLE - The Wellsville Touchdown Club will be selling "Tiger Paws" painted on your sidewalk. They are bright orange 18"x18". All proceeds will help support the Daw Middle School and Wellsville High School football players. The cost of each paw is $10. To place orders, call Chris Bost at 330-532-4479 or Rodger Miller at 330-383-9956.
West Point Rod & Gun Club turkey shoots
WEST POINT - The West Point Rod & Gun Club will be holding turkey shoots at noon on Sundays.
Chester-Newell Sportsmen Club activities
CHESTER - The Chester-Newell Sportsmen Club is having Turkey Shoots at 10 a.m. on Sundays through Nov. 11. Cost per shot is $2, lucky X and $5 per shot money shoots. Factory guns and tubes only. Cash, meat, novelty and 50/50 shoots. Kids and ladies welcome. Kitchen open. For more information, call John at 304-374-1451 or Vance at 304-387-0095.


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CONCERT REVIEW: Paolo Nutini w/ Matt Hires and Erin McCarley @ Opera House, Toronto – July 31, 2009
Despite Scottish singer, Paolo Nutini, not being as well known here as he is across the pond, the Opera House opened to a surprisingly sold out crowd. His demographic seems to be college-age girls and middle-aged women (who also dragged along husbands and boyfriends). I guess that goes to show that a handsome musician with an accent will make just about any girl swoon at any age.
To open the show was Matt Hires, a singer-songwriter with boyish good looks and a good voice. But "good" is nothing too special. The best song he performed wasn't even written by him, but a cover of MGMT's "Kids".
Erin McCarley, most known for her songs featured on TV shows like One Tree Hill and Grey's Anatomy, was the second opening artist. She was alot better live than I expected and played a half hour set which included her popular songs "Pony (It's Okay)" and "Love, Save the Empty". But then again, popular is a relative term as many people in the venue didn't seem to know or care who she was – talking through her entire set.
Therefore, a little tip: If you're an artist who wants to get noticed, Paolo Nutini might not be the best artist to open for – his fans don't seem very receptive.
At around 10 PM, Paolo Nutini finally took to the stage to perform to a crowd of restless and seemingly sexually frustrated bra-throwing girls. He immediately commanded the stage with his soul-gutting performances and powerful vocals, but his stage banter was seriously lacking – and when he did attempt a little conversation, his accent was so thick us Canadians had no way of understanding. However, that didn't seem to bother his lovestruck audience who beamed from ear to ear, not even trying to hide their silly little schoolgirl crushes. Nutini had the crowd hanging on his every word and singing along with every song, not missing a beat. So, if you're not too familiar with his lyrics – study up, my friend – or you'll be the only one left standing there all shifty-eyed clapping along and pretending to sing along all the while hoping he never holds the mic up to your lips. There's no denying that Nutini knows how to put on one hell of a show, but it's his off-stage persona that really leave a bad taste in your mouth. You would think that after a sold-out concert, he would want to stay a while to thank his fans. But no – instead he make a run for his tour bus and slams the door without even a second look leaving many girls broken-hearted. If you go to a Paolo Nutini concert expecting a show – one energy-charged charged show you'll get – but if you're expecting to get a little meet and greet with your favourite artist, you can expect to leave disappointed.
Paolo Nutini fans are hardcore. Devout followers; there is rarely ever an in-between (in my experience). If however, you just happen to fall into the latter, be prepared to fight your way though an obnoxiously rude crowd. Oh, and apparently smoking is a prerequisite. I guess someone forgot to send me the memo.


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quote IcarusAbidesMe too! Yea i know that the power of the computer i want is stupid for just FM but mine sometimes lags a bit on 3d when i can bare to watch if im not doing too well in the gamekyleb1985 That's quality, thought it would take longer than that. I'm looking at getting a new laptop soon mainly for FM.
quote kyleb1985If you pre-order from Amazon you don't pay until the game comes out or just before so November 1st ish and you still get beta access.IcarusAbides
That is quite good mate might have to nip along and see them when i get a free weekend, still not pre ordered the game though :-( cash is tight at min might have to wait a few weeks :-(
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on December 16, 2012 - 1:00 AM
The hostile divide between technophiles and technophobes is never greater than during the gift-giving season. That's when the wannabe gadget givers get repeatedly rebuffed by people they love who insist they don't want:
a) email
b) a cellphone
c) a computer
d) "Or any of that stuff!"
Many of them are older adults, particularly those who were already in their senior years when the World Wide Web and electronic mail were entering the mainstream in the 1990s. Others are people who feel like their lives are fine the way they are, and they don't want them complicated by anything, well, complicated.
To help bridge this great divide, The News has come up with a short list of user-friendly email and software systems, computers and cellphones to gradually introduce technophobes to the benefits of the digital age.
But first, a brief lecture.
Don't buy or sign up your loved one for any item on the list if you're not willing to do the necessary setup to make it as easy to use as possible. Be prepared for resistance. Take the time to show the recipient, step-by-step, how everything works, and don't sound patronizing while you do it.
Let's be honest. Technophiles see technology as a major life enhancer, even a necessity to good living.
Contrast that with those who have deliberately stepped off the technology treadmill. For them, technology isn't something that connects people and builds relationships. It may even been viewed as an inhibitor to real personal contact, a privacy killer and an enabler for incredible social rudeness. They aren't wrong.
The must-have gadgets also can come with a sense of fear and resentment.
"It scares me because there's so much information out there," said Amherst senior Joan Factor.
A Pew Research study from earlier this year indicated that, for the first time, a slight majority of people over age 65 use the Internet. However, 47 percent still remain offline. After age 75, only 34 percent use the Internet.
Aside from issues like complexity and cost, some technology comes with barriers for those hampered by vision, hearing and dexterity limitations.
Then there are those like Amherst resident Cynthia Darone, 69. A former teacher with a master's degree, she has a huge flat-screen TV at home, loves her DVR, and can even hunt down theater showtime information online, but she hates email and rarely uses the cellphone she carries around with her for emergencies.
"The problem with it is, it does a lot of other stuff, too," Darone said, referring to a time her phone's contact list "disappeared." Her housekeeper helped her find it again. "I can't do the email either. It's a pain in the neck."
It's not that she can't figure it out, she clarified. She's just not motivated.
"A lot of this technology is really helping the younger generation, not helping the older generation," said Peter Radsliff, founder of the Aging Technology Alliance and CEO of Presto Mail Service. "If you think about it, the level of technology change that has been in the lifetime of these people is so significant, and these other people just want to dismiss them as people who just don't get it. But you know what? They get it. They just don't want it."
Of course, tech users have many good reasons for wanting their loved one digitally connected. They want them to be less isolated, more connected to other family members who are more inclined to tap or Swype a keypad than pick up the phone. And they want them to be safe, to have ready access to help in case of trouble.
"That isn't to say arm-twisting isn't involved," said Neil Grabowsky, inventor of the Celery service that turns a fax machine into an email device.
He said about half the people who are given the service initially say they don't want it – until email "letters" and pictures of the grandkids start magically showing up in their living room.
"Once that happens, you pretty much can't lift the machine out of their hands," he said.
With that in mind, here are some News picks of should-have technology that, introduced properly, may bring your technophobe – and you – some peace of mind and mutual enjoyment. Each list also includes products that can be tailored for use for those with vision and hearing impairments.
Non-computer email systems
Marian Schultz, 87, was one of a group of seniors at the Amherst senior center who said she didn't have a computer or email and didn't see the need for either.
"What would I use it for?" she asked. "I have a phone."
The suggestion that children or grandchildren might communicate with them more frequently if they were digitally connected was met with deep skepticism and a general lecture on the need for young people to spend more time talking face-to-face or over the phone than with their thumbs.
For those of you who are bent on changing this point of view, we recommend:
What is it: A glorified printer that allows people without computers to receive email, photos, documents and more without doing a thing.
Device cost: $99.99
Plan cost: $12.50 to $14.99 a month
Pros: This simple, oversized printer requires no learning on the part of the user. It plugs into a regular phone outlet and, like magic, prints out emails and any attached photos or PDF files from loved ones as they arrive. It uses regular paper and HP printer ink. Senders can customize emails with decorative borders and enhancements to make them appear more letterlike. Gift-givers can also sign up the recipient to automatically receive news, comics, crossword puzzles and health tips. "All they know is there's a beige machine that spits out stuff from their family and friends," Radsliff said. "They didn't need to learn anything new."
Cons: This is a one-way communication service. Also, some attachments, like Microsoft Word documents, must be converted to a PDF in order to be received.
What is it: A service that converts any fax-capable machine into a device that can receive and send emails.
Plan cost: $13.98 to $19.99 a month
Pros: People automatically receive emails and image and PDF attachments through a regular phone line, like Presto. Users also can electronically send handwritten letters, which the Celery Service automatically converts into an image document and emails to whoever is on the user's contact list. Clear instructions and machine decals make the process straightforward.
Cons: This requires the user to own or purchase – and maintain – a fax or all-in-one fax capable machine and takes several (well-marked) button presses to send a letter.
Simplified computer software
Some people have computers, but have given up on them, or they use them as oversized word processors and to play solitaire. For those who need a simpler computer layout so they can be enticed to use their machines for communication and information, we recommend:
PawPaw Mail
What is it: An extremely simple email interface for seniors or others who might be willing to use email but would find most email browsers too daunting, complicated or distracting to navigate.
Plan cost: $8 a month
Pros: The interface that greets users makes it super easy for anyone to read mail, receive images and send replies. Large type, buttons with visual cues, and a particularly useful address book format for anyone with memory problems. For loved ones who don't live nearby, PawPaw easily allows and encourages other tech-savvy family members or caregivers to provide remote support.
Cons: Software limited to email use.
What is it: A Windows-based software program that replaces the more complicated computer interface with one that provides a much simpler and easy-to-understand window to access email, photos, games and the Internet.
Plan cost: $149 one-time cost, or $8 a month
Pros: Works with both standard and touch-screen computers. Clear email function lets the user respond to emails by either typing or speaking. Tech-savvy family members can maintain the software program remotely.
Cons: Supports only Windows XP or later, not designed for Macs. High-speed Internet connection is recommended.
What is it: A Windows-based software program similar to PointerWare, but with some different user options.
Plan cost: $9.95 a month
Pros: This program can do much of what PointerWare does, in both standard and touch-screen format, with options for those who want more, easy menu options for news and online shopping.
Cons: Cost. Supports only Windows XP or later, not designed for Macs. No email voice option. High-speed Internet connection is required.
Computers, etc.
Not everyone is meant to have a computer, but some people appreciate all the nifty things computers can do. What they may need is a simpler and more bug-proof system. You could hand over your iPad and see what happens. Otherwise, we recommend:
Telikin Also branded as "The Wow! Computer" (www.telikin.com)
What is it: An all-in-one touch-screen computer with an easy interface and large-letter keyboard.
Cost: $699 to $999, depending on screen size
Pros: This Linux-based computer comes preloaded with most of the things a novice or senior computer user could want in a clear, easy-to-understand interface that is virus-resistant. Email, video chats, social networking, Web browsing, games and quick update features for weather and news are all easy to find and do. Wi-Fi ready. US-based "VIP" support is available.
Cons: Expensive. Also requires a high-speed Internet connection. VIP support also costs $9.95 after the first month.
Mobile phones
There are fewer and fewer cellphone holdouts these days as companies make phones that are cheaper and simpler, and more people are recognizing the phone's value as a safety device.
Those listed here are for those who still don't have a cellphone, or who have a phone that is hard to use.
These phones emphasize not only design simplicity, but low, no-contract pricing. These phones generally share similar features like texting, speakerphone, calendar, calculator and hearing-aid compatibility. All are available for purchase online, but we've also listed where you are most likely to find them in stores.
Doro PhoneEasy 410
Provider: Consumer Cellular
Retail price: $60
Lowest monthly plan cost: $10 (25 cents per minute)
Where to find in-store: Sears
Pros: Easy-to-hold flip phone; good-sized, high-contrast, backlit keypad and screen with large, easy-to-read display and one-touch emergency call button. No small, unnecessary buttons; very intuitive menu. Also includes an FM radio.
Cons: Phone cost. Also, the Doro 410 is already being replaced online by a chunkier Doro 618, which will add a simple camera, three one-touch call buttons, flashlight and front call display.
Samsung Gusto 2
Provider: Verizon
Retail price: List price $49.99; can be found for under $30
Lowest monthly plan cost: 99 cents per day when phone is used, then 25 cents per minute
Where to find in-store: Most big-box and discount stores, electronics retailers
Pros: Simple design "regular" flip phone with nice, subtly contoured keypad buttons, easy-to-see numbers. Basic, easy-to-use design that also offers a camera, Bluetooth, voice commands and adjustable font sizes.
Cons: May offer more features and menu options than a basic user may want.
Alcatel "The Big Easy"
(www.alcatelonetouch.com/ usa/products/simplicity/usa_a382g.html)
Provider: Tracfone
Retail price: $30
Lowest monthly plan cost: $9.99 (30 free minutes)
Where to buy: Walmart, discount stores
Pros: A bar phone with a big color screen and super-simple keypad with huge, backlit numbers and an easy-to-navigate menu, plus FM radio. Works well for anyone craving at-a-glance simplicity and for people who may have sight or dexterity issues.
Cons: Larger size may be a turnoff for some.
Jitterbug Plus
Provider: Great Call
Retail price: List price $119; on sale now for $99; $35 activation charge
Lowest monthly plan cost: $14.99 (50 free minutes)
Where to buy: Sears, Best Buy
Pros: The pioneering phone for seniors still features separated, backlit numbers and its easy yes/no menu system, but now also includes a camera and more traditional design. The phone's greatest advantage is its support of other GreatCall apps like 24/7 access to a live nurse, the 5Star response system, medication reminders and other simple-access updates like weather, sports or horoscopes.
Cons: Cost. The phone itself is expensive, and many of the apps require an extra monthly charge. A strong alternative for people wanting more of a safety device is Great Call's stand-alone 5Star Urgent Response one-touch communication device with GPS and 24/7 access to a helpful agent or nurse.
Samsung Entro
Provider: Virgin Mobile
Retail price: $14.99
Lowest monthly plan cost: $20 (400 free minutes)
Where to buy: Most big and discount stores, electronics retailers
Pros: Probably the cheapest and most basic "regular" flip phone on the market. Straightforward keypad that avoids picture icons, GPS and voice command enabled.
Cons: No Bluetooth. Virgin Mobile coverage can be spotty in areas.
email: firstname.lastname@example.com


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TV Watch
Jennifer Lawrence and Jason Sudeikis Joke Around in SNL Promos
After giving a humorous acceptance speech at the Golden Globe Awards on Sunday, the Silver Linings Playbook star, 22, will host Saturday Night Live on Saturday.
Teaming up with the SNL's newly engaged star Jason Sudeikis, the pair shot some hilarious promos for the big night, which will also feature musical guest The Lumineers.
In one promo, Sudeikis introduces Lawrence, who confidently replies, "Yes! First, a Golden Globe, now this? I don't even know who to thank!"
Another promo is an ode to Silver Linings, with Sudeikis wearing the signature trash bag Bradley Cooper wore in the Academy Award-nominated film.
"Just trying to drop some of this winter weight, B. Coop style," he says. Lawrence responds, "It doesn't work if you're just standing there. You have to be running."
An additional promo shows Sudeikis getting down about never having been nominated for a Globe, which gets Lawrence to sing his praises.
"You're really funny, and you're a really good actor, you're grounded and you listen," she says. "And you're very handsome. Should I stop? Well, you're subtle and you have amazing charisma."
SNL airs Saturday (11:30 p.m. ET) on NBC.


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Mozart Festival FinaleThe Mendelssohn Choir joins the PSO in Mozart's celebratory and moving "Coronation" Mass. Creative force Don Marinelli joins Manfred Honeck and the PSO for the finale of the Mozart Festival, featuring a unique presentation of selections from Mozart's most famous operas.05/02/2014 - 05/04/201405/02 - 8:00 pm05/04 - 2:30 pmHeinz Hall, 600 Penn Ave., Pittsburgh, PAwebsite | map
Hope and GravityTracy Brigden directs the world premiere of Michael Hollinger's play in which lives overlap and elevators stop on random floors as ten characters are compellingly revealed in a nonlinear comedy about fate. From a backyard squabble to an unlikely hotel hookup, chance encounters and rocky relationships unfold through nine stories and one momentous leap of faith.05/03/2014 - 05/25/20141300 Bingham Street Pittsburgh, PAwebsite | map
Big Band and BeyondThrill to the music that defined the American Century. Susan Medley directs the PCC with the Jazz Conspiracy Swingtet in hits by Benny Goodman, Glenn Miller, Tommy Dorsey, and more.05/03/2014 - 05/04/201405/03 - 7:30 pm05/04 - 4:00 pmLocation: variouswebsite
Happy 125th Anniversary, JohnstownIstvan Jaray conducts Lucas Richman's A Time for Heroes, Nancy Galbraith's Fantasy for Orchestra, and two works by Johnstown's own early-20th century master of Americana, Charles Wakefield Cadman: "My Own Johnstown" and "Pennsylvania Symphony."05/03/2014Time: 7:30 pmPasquerilla Performing Arts Center, 450 Schoolhouse Rd., Johnstown, PAwebsite | map
Cassandra WilsonCassandra Wilson has been described as "a singer blessed with an unmistakable timbre and attack who has expanded the playing field" by incorporating blues, country and folk music into her work. Her awards include: two Grammys, the Django D'Or, The Edison Music Award, a marker on the Mississippi Blues Trail, and the 2012 Echo Award for Jazz. She also performed a lead role in Wynton Marsalis' "Blood on the Fields," the first jazz work to receive a Pulitzer Prize.05/03/2014Time: 9:30 pm1815 Metropolitan St, Pittsburgh, PAwebsite | map
PYCO ConcertRossini: William Tell Overture; Elgar: Serenade for Strings; Khatchaturian: Adagio from Spartacus; Delibes: Waltz from Coppelia; Leroy Anderson: The Typewriter; Tchaikovsky: Symphony #3, Finale; Duke Ellington: A Medley for Orchestra05/04/2014Time: 5pmLocation: North Hills Middle Schoolwebsite
Sounds Upstairs - James Ferla & Roger ZahabGuitarist James Ferla and violinist Roger Zahab play sparkling, fiery and elegant duo and solo music including David Leisner's Dances in the Madhouse, compositions by Piazzolla, Zahab and others.05/04/2014Time: 3:30 pmCarnegie Library of Pittsburgh, 4400 Forbes Ave., Pittsburgh, PAwebsite | map
Music 101 - Noah Bendix-Balgley PSO Concertmaster Noah Bendix-Balgley gives an informal lecture, titled "Concertmaster: The Symphony's Quarterback." He will discuss his life and career, and his role as PSO Concertmaster, and also take questions from the audience.05/07/2014Time: 12:30 pmHeinz Hall, 600 Penn Ave., Pittsburgh, PAwebsite | map
Ping at Trinity CathedralThe virtuoso madrigal ensemble Ping, a quintet founded atr CMU, presents a lunchtime program at Trinity Cathedral in the heart of downtown Pittsburgh. This informal concert will feature a variety of sacred and secular music, including works by Ping member and Trinity Cathedral composer-in-residence, Sean Salamon.05/07/2014Time: 11:30 amLocation: Trinity Episcopal Cathedral, 328 Sixth Ave, Pittsburgh, PAwebsite
Comfort ZoneMarlon Youngblood's "Comfort Zone," featuring Tony Award nominee Anthony Chisholm and directed by Mark Whitehead, is about the aftermath of a shooting and how it impacts a community. "Comfort Zone" is based on the searing hit production from last year's Theatre Festival in Black & White.05/09/2014 - 05/31/2014Pittsburgh Playwrights Theater, 937 Liberty Ave., Pittsburgh, PAwebsite | map
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Leader of gun owners' group speaks in city
October 3, 2013
"You may be the federal government, but you ain't my boss," said Larry Pratt, executive director of Gun Owners of America, at Wednesday evening's Williamsport Tea Party meeting at the Genetti Hotel....
That is what I noticed also Jerry and the second photo shows very few there.
0 Agrees | 2 Disagrees | Report Abuse »
I'm not in any way making fun of the people in the photo.
This article discussed a view point and political agenda that, rightly or wrongly so, is typically stereotyped to older, white people. The photo mirrored that stereotype.
That's what I noticed.
Perhaps the photos were representative of the people in the room, perhaps not. Maybe someone who was there could comment and tell us if there were younger people there that did not make the paper.
0 Agrees | 1 Disagrees | Report Abuse »
It is simply a shame that this is what America has come to. These people are exactly what is wrong with this country! They want what they want regardless of facts or reality. They could not care less for anyone besides their own self gratification. They have made decisions long ago based on little fact and they will support that decision until we pry their guns from their cold dead hands. And the Sun Gazette will report on this foolishness every time. Why can't we just marginalize these people like they deserve and move on as a country?
0 Agrees | 2 Disagrees | Report Abuse »
Jerry and Rick, just assume I'm slow and clue me in what you find so obvious/amusing in these photos in relation to this article.
2 Agrees | 1 Disagrees | Report Abuse »
I don't always read the comments before I post my own two cents worth but in this case I did.
My intention was to comment on the photos but I see that others already have, and they see what I see.
So, yeah.
There you have it.
3 Agrees | 2 Disagrees | Report Abuse »
Looks obvious to me and apparently to someone else since they agreed.
2 Agrees | 2 Disagrees | Report Abuse »
Rick, what exactly about those photos do you find amusing? The fact that they are reciting The Pledge of Allegiance?
3 Agrees | 1 Disagrees | Report Abuse »
The photos, oh those photos, need I say more?
3 Agrees | 3 Disagrees | Report Abuse »
It is folks like Mr. Pratt that truly show how vastly diverse the thought spectrum is in these United States.
3 Agrees | 0 Disagrees | Report Abuse »
Actually he is right. When legal gun ownership goes up, gun crimes go down. This statistic has been proved in many major cities across America without exception. Its even proven in gun friendly states. The flip side also shows in cities where legal gun ownership is denied, gun crimes are rising......
5 Agrees | 1 Disagrees | Report Abuse »
This was a nice funny read this morning. Thanks. Mr. Pratt wow. Thanks.
1 Agrees | 1 Disagrees | Report Abuse »
Aw, jeez...one o' Pat Buchanan's "disciples". Yeah...that's what's "needed", locally.
Larry Pratt [Wikipedia]
3 Agrees | 5 Disagrees | Report Abuse »
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We may not want to admit it, but as mothers we all have many fears.
Mothering is an adventure, which has no guide, no requirements, no specific description, and no matter how much "advice" you receive, there is constantly uncharted territory.
When my middle child was 4 years old, I experienced one of the worst fears a mom can be faced with: My child was gone. He was nowhere in sight and no one knew where he was.
He and his older sister were taking summer swimming lessons at our neighborhood pool. Another mom at the pool offered to stay with my kids during their lesson, so I could go pick up my baby from my husband. I told my kids I was leaving for just a few minutes to pick up their baby brother. I instructed them to go straight to this mom after the lesson and she would have their towels for them.
It was a 15-minute trip to my husband's office to retrieve my little one and I was back to the pool. As soon as I got out of the car, the other mom came running out of the pool entrance, "I can't find Grayson!"
"What do you mean you can't find him?" I said. "Did you look in the bathroom?"
"How about the volleyball court? He loves the sand…."
He's not there.
"The playground?"
At first, I just figured he was somewhere in close proximity playing in his imaginary world…not registering he "was gone." He was very adventurous and brave. He liked to explore. He couldn't be "gone" anywhere. His whole life I had known his exact location at every moment.
I rushed into the pool area with my baby in the stroller and my oldest next to me. I looked everywhere, even the bottom of the pool. My curious, little 4-year-old boy was nowhere to be found.
The other mom kept apologizing. I can imagine the fear she felt herself, as a mom and as his temporary caretaker. I never once felt angry with her. It could happen to any of us at any time. Moms with "stealth" children know this to be true. You learn to keep your mom radar on high at all times, but even then they still manage to go undetected at times.
Finally, someone at the pool remarked they had seen a little boy leaving the pool. He was out there somewhere…my heart sank.
I shoved the stroller at the mom and commanded my daughter to stay next to her and ran to my car.
"I'm going to look for him!" I said.
I got in the car and sat for a terrorizing second. Where are you, little boy? I asked. I grabbed my phone. I needed to call the police.
My heart raced and my hands shook, as I slammed my car into drive… where was I going? Where should I look?
Home! My first instinct was to go home. It's the only place he knows. We walk to the pool everyday. He knows the way and to stop at the corner to look for cars. But it wasn't him I was scared of…it was someone else finding my sweet little boy in his swim trunks and fireman galoshes carrying his Thomas the Tank Engine towel.
It was only two blocks to my home from the pool, and it was the longest two blocks of my life. As I rounded the curve before our house, I didn't take my eyes off the front porch.
There, my small boy was sitting on the porch swing, all alone.
I missed the driveway, literally driving over the sidewalk onto the lawn. I jumped out of the car and ran to my baby, fell to my knees and enveloped him completely. He was safe. He was home.
"Why did you leave the pool? Why didn't you stay?" I asked.
"I missed you, Mommy," he said, "and I wanted to come home. I thought you were at home. You weren't here. I was all alone."
He had simply followed my directions, exactly as I had given them. He went to the other mom after his lesson and got his towel. I never gave him any information past that point. I never told him to stay with her, or his sister, until I returned. He did what he always did after he got his towel - he went home.
I was lucky and I knew it. Lesson learned; even 4-year-olds need all the information.
Susie Mearsha is married with three children. Read her Mondays on Greeley Moms.
I got in the car and sat for a terrorizing second. Where are you, little boy? I asked. I grabbed my phone. I needed to call the police.


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DNU - Robin Baron Design Group
Robin Baron is an interior designer, web-video host and frequent TV/radio personality. Her New York City-based firm offers fashion-forward styling for every aesthetic, helping clients define their taste and reflect their decorative passions. Robin's collection offers an array of colors and styles that invite you to find your own fabulousness.


text:
Intel® EP80579 Software for Security on Linux*: Guide
About this Manual
This Getting Started Guide documents the instructions to obtain, build (if necessary), install, and execute the Intel® EP80579 Software for Security Applications on Intel® QuickAssist Technology release package. Additionally, this document describes some brief instructions on configuring the Intel® EP80579 integrated processor with Intel® QuickAssist Technology development board.
Read the full Intel® EP80579 Software for Security on Linux*Getting Started Guide.


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"I Was A Rat!" insists a scruffy page boy who turns up one evening on the doorstep of old married couple Bob and Joan. But what is he now? A terrifying monster rampaging in the sewers? A money-spinning fairground freak? A champion wriggler and a downy card? Or just an ordinary boy, though a little ratty in his habits?
Philip Pullman's glorious and gripping story is brought to life on the professional stage for the first time in the UK. Combining humour, fantasy, and adventure this moving and darkly comic tale slowly reveals its connection to one of the most famous fairy tales of all time. Full of music, fantastic physical performances and unforgettable images I Was A Rat! will surprise, delight and move audiences of all ages.
Adapted and directed by Teresa Ludovico, artistic director of Teatro Kismet in Bari, Southern Italy, best known here for her thrilling visual and physical productions of Beauty and the Beast, The Snow Queen and The Mermaid Princess.
Lightset design by Vincent Longuemare
Costume design by Luigi Spezzacatene
Composer: Frank Moon
Music: Recorded by members of The Destroyers, with additional music played live by members of the company
Movement Director: Yann Seabra
Sound Design by Dan Hoole
Produced in association with Judy Owen Ltd
"It is a show to please all ages, it is supremely theatrical, and it has a heart."
The Telegraph
"Genuine wit and style"
The Guardian
"It seems an oddball choice for a 100th-anniversary production, but it's not long into this frisky stage version of Philip Pullman's 1999 children's story before you sniff a hit."
The Sunday Times
"I Was a Rat! suits all ages in its fantastically original theatricality and exuberant warmth and humour."
London Theatre Reviews
"Funny and poignant by turns."
Birmingham Mail
"Yet another outstanding production for the REP."
The Public Reviews
"A superb evening of entertainment."
What's On Stage
"I can't think of a better show to encourage youngsters to return to the theatre, which is surely the secret to the success of a venue which has lasted 100 years."
Solihull News
"I've phoned everybody I can think of to say don't miss it. Just don't."
Lichfield Live
"An inspired choice by Birmingham Rep, which in its centenary year, is still setting the standard for other theatres to follow."
Express and Star
The Old Rep
- Address: Station Street, (Nearest car park is on Dudley Street), Birmingham, B5 4DY
- Box Office: 0121 236 4455
- Phone: 0121 236 4455


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NSCLC is "Major Battlefield" as Merck,...
Developers of DTC Genetic Testing Are...
LC-MS Gains Favor Due To the...
Expanding Use of NGS Has Largely...
Of all the activities that constitute a bioprocessing operation, a good argument could be made that the most critical step involves optimizing cell-line development.
That was one of the main messages delivered at CHI's "Bioprocessing Summit", in the late summer.
Jesús Zurdo, Ph.D., head of innovation for biopharma development at Lonza Biologics, discussed the challenges and advantages of various strategies for minimizing high attrition rates related to "dwindling R&D productivity and spiraling development costs," and the resulting cost pressures on process development for microbial fermentation and mammalian cell culture.
According to Dr. Zurdo's model, risk may enter the picture anywhere during development, including preclinical studies, human testing, or manufacturing.
"Because we get involved early in the development process, we are often the first to notice issues in the form of low yield, aggregation, low chemical stability, immunogenicity, and immunotoxicology," he said.
Dr. Zurdo's approach to assessing "developability" involves in silico computational methods to predict productivity, aggregation, stability, and immunogenicity. This helps investigators select, from a collection of potential candidates, a molecule optimized with respect to these properties.
Next he examines, through in vitro and ex vivo assays on cultured human cells, immunogenicity-related events such as T- and B-cell activation and cytokine secretion. The objective of this two-pronged is not to characterize the molecule fully, but to select optimal candidates with low risk of stability and immunogenicity issues.
"Once you are comfortable with biological activity, you can select the lead molecule based on all these assays," he added.
Most biopharmaceutical developers employ some of these activities already.
"They attempt to bring research and development teams closer together to differing degrees. But our computational approach, which reduces cost while increasing throughput, allows investigators to explore things they could not otherwise explore."
Lonza's other innovation consists of integrating stability and immunogenicity studies. "Only a few companies have achieved this, and it's unheard of in the CMO space," claimed Dr. Zurdo.
Identifying and analyzing for key quality attributes early in development, rather than trying to solve them through process tweaks, requires a higher initial commitment but its reward is lower risk and, ultimately, greater flexibility in designing the eventual manufacturing process.
Delivery and formulation are two other factors that Dr. Zurdo believes companies should be thinking about earlier rather than later. The later these critical development activities begin, the more constrained the development space will be with respect to concentration and administration route.
Biopharm is perhaps the only industry, according to Dr. Zurdo, that generates prototypes—candidate molecules—through a fully developed commercial manufacturing process. "And this affects development cost and time," explained Dr. Zurdo.
Industry must continue to seek ways to create "prototypes" that are safe (through early developability and immunogenicity testing), but which also facilitate the rapid transitioning of candidate molecules into the clinic. Only after a molecule has shown promise in early-stage clinical phases should the all-out effort be placed on a Phase III or production-worthy process.
Through her presentation, Marguerite Campbell, a scientist in biologics research at Janssen Research & Development, unveiled a unique approach to reducing biotherapeutic attrition. According to Campbell, molecules continue to fail during preclinical development despite great strides in molecule and cell development. Her company's technique for minimizing early-stage attrition involves front-loading early development by introducing as many as five different cell lines that express an equal number of candidate molecules.
This parallel-development approach requires analytical, purification, and formulation to become involved early in the process on multiple molecules.
"Once the preclinical enabling stage begins we continue to engage all stakeholders," Campbell said. "Their involvement throughout development allows us to create shorter learning cycles, with go/no-go decision points as we build molecules and cell lines to fit our manufacturing platform."
The objective is to test and learn as much as possible about multiple candidates before committing to one molecule. "It's all about options."
According to Campbell the parallel approach is less risky than committing to five different projects for five different therapeutic targets or indications. She presented a case study of an oncology drug. At initiation, her group had two basic molecules with differing mechanisms of action: one, thought to be the most promising, with two variants and a back-up protein with one variant.
The first group of molecules failed due to aggregation problems, which under a more traditional development paradigm might have ended the project then and there. The second variant of the backup molecule did not exhibit the aggregation problem and showed high activity and the potential for market differentiation.
So in the end, the molecule that may have been the fifth-most-promising was the one that moved forward.
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Novum Pharma recently raised the price of an acne cream by over 3,900% in less than a year-and-a-half and Mylan increased price of EpiPen from $100 to $608 . Do you think pharmaceutical companies need to be subjected to price controls?
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If you're looking for a versatile, durable, smooth-riding, and affordable fishing boat, look no further. The GRIZZLY 1754 MVX Jon will accept up to a 30-horsepower outboard (optional), and the roomy interior, including an up-sized front fishing deck and 2 pedestal seat bases, make it ideal for fishing or bowhunting.
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Jeffery Phelps/Associated Press
Jeffery Phelps/Associated Press
Carlos Gonzalez is happy to see Troy Tulowitzki back in the Colorado Rockies� lineup.
Gonzalez homered for the second consecutive game and drove in two runs to lead the Rockies over the Milwaukee Brewers 8-4 Tuesday night, giving Walt Weiss his first win as a major league manager.
Tulowitzki also homered for the second consecutive game and drove in two runs, giving him four runs batted in for the season.
Tulowitzki is off to a quick start after missing the last four months of the 2012 season with an injured left groin that required surgery. The All-Star shortstop went 2-for-5 with a homer and two RBIs in Monday�s loss on opening day.
�It�s great to have him out there,� Gonzalez said. �Any team would want him on their side. He is one of those players that can win games all by himself.�
Weiss, who posted his first victory, a year after managing his son�s high school team, had a lot of praise for Tulowitzki and Gonzalez after the game.
�Tulowitzki looks great,� Weiss said. �Having him and Carlos in the three and four hole is very nice. Those two guys are going to have to be the ones if we are going to make a push this year.�
Gonzalez said he is seeing the ball well early in the season.
�I am not trying to hit home runs, but when pitchers make mistakes in this league, you have to make them pay,� he said. �So far, I feel really good at the plate and it is paying off.�
While the home runs were important, both Weiss and Gonzalez talked about the importance of the Rockies� three-run seventh inning that features four singles, a walk and a sacrifice fly.
�We really had some good at-bats (Tuesday),� Weiss said. �We did a little bit of everything out there. I know that if the game is close, our offense will do something.�
Edgmer Escalona (1-0) pitched 1 2/3 innings of scoreless relief for the victory.
Jorge De La Rosa started for Colorado and pitched 4 1-3 innings, giving up four runs and five hits. Rafael Betancourt got the last out to record his first save.
Marco Estrada started and went five innings for Milwaukee. He gave up four runs and nine hits and struck out eight.
Tulowitzki hit a solo homer in the third to make it 2-all. Gonzalez�s two-run homer in the fifth tied it at 4.
The Rockies broke it open in the seventh off Brewers relievers Michael Gonzalez (0-1) and Burke Badenhop.
Dexter Fowler had a leadoff walk, Josh Rutledge bunted for a hit, and Gonzalez singled to load the base. Tulowitzki�s sacrifice fly put Colorado ahead, and Michael Cuddyer and Todd Helton added RBI singles.
Brewers manager Ron Roenicke was disappointed about the seventh inning.
�What do you do about an inning like that?� he said. �That�s weird. You don�t see too many innings that could go bad with really pretty good pitches. A bunt that maybe we should make a play on. The broken bat � I don�t know what you do about that thing. It just didn�t go well.�
Roenicke said Estrada struggled with his command.
�His off-speed pitches, which he usually can get command of as the game goes along, he didn�t get command of,� he said.
Rutledge had a sacrifice fly in the eighth.
Chris Nelson�s RBI single in the second gave the Rockies a 1-0 lead. Carlos Gomez�s RBI double and Estrada�s RBI single in the bottom half put Milwaukee ahead 2-1.
Ryan Braun hit a two-run shot into the right-field seats in the third, his first home run of the season.


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As Immunotherapy Revolutionizes the Cancer Treatment...
NSCLC is "Major Battlefield" as Merck,...
Expanding Use of NGS Has Largely...
Developers of DTC Genetic Testing Are...
Merck & Co. expanded its reach into the HIV arena by signing two licensing agreements for investigational drug candidates. One deal is with Chimerix, based in Research Triangle Park, NC, and the other is with Yamasa of Choshi, Japan. Merck is also planning to advance an internally developed HIV candidate, MK-1439, into a Phase IIb trial.
"Despite the tremendous advances made over the past 20 years, there remains considerable unmet need in the treatment of HIV infection," said Robin D. Isaacs, M.D., vice president, infectious disease clinical research, Merck Research Laboratories. "Merck remains committed to improving on the standard of care for HIV therapy."
Chimerix is granting Merck exclusive worldwide rights to its HIV treatment candidate CMX157. Chimerix will receive $17.5 million up-front and be eligible for up to $151 million in milestone payments plus royalties on future sales, while Merck will have responsibility for developing and commercializing the compound, an investigational oral nucleoside reverse transcriptase inhibitor.
"This is what we hope will be part of the next generation of anti-HIV therapies," Kenneth I. Moch, president and CEO of Chimerix, told GEN. "We'd been seeking a partner with financial resources and the will to develop a compound that will be part of a combination therapy, and certainly Merck is that type of partner."
Moch said the agreement "is an important validation of our proprietary lipid technology," which underpins both CMX157 and CMX001, Chimerix' lead antiviral compound.
Merck also agreed to develop Yamasa's EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine), a novel nucleoside reverse transcriptase inhibitor candidate that is in preclinical studies and has shown antiviral activity toward highly resistant HIV strains. As part of the agreement, Merck will pay an up-front fee and future milestone payments in return for exclusive worldwide license rights. This candidate was discovered in collaboration with a group led by HIV research scientist Dr. Hiroaki Mitsuya of Kumamoto University's Center for AIDS Research in Japan.
Speaking about what this collaboration means for Chimerix, Moch said license agreement funds will help the firm fund further clinical trials of the company's lead antiviral compound, CMX001, a broad spectrum lipid acyclic nucleoside phosphonate that inhibits double-stranded DNA viruses including cytomegalovirus (CMV), adenovirus, BK virus (BKV), herpes simplex virus, and variola (smallpox).
On Monday, Chimerix presented data at the 24th International Congress of the Transplantation Society in Berlin concluding that CMX001 has potential to reduce end-organ damage associated with BKV in hematopoietic stem cell transplant recipients. Data came from a Phase II study that was the largest retrospective analysis of BKV-associated signs and symptoms collected in a randomized, placebo-controlled trial reported to date.
Chimerix has sat down with FDA officials for an end-of-Phase II meeting to discuss CMX001 against CMV infection in stem cell transplantation. "We are proceeding as rapidly as possible, aggressively, toward Phase III in hematopoietic stem cell transplant patients, starting with patient dosing in 2013," Moch said.
In addition to these deals, Merck says it plans to advance into Phase IIb clinical trial an internally developed candidate, MK-1439, a next-generation non-nucleoside reverse transcriptase inhibitor. Merck is initiating a dose-ranging clinical trial to evaluate the safety and tolerability and efficacy of MK-1439 in HIV positive, treatment-naive patients compared to efavirenz, both in combination with Truvada. The trial is expected to commence in September.
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May 10, 2013
The case of a former Tygart Valley Regional Jail correctional officer accused of forcing a female inmate to engage in sexual acts has been bound over to Randolph County Circuit Court....
Is absolutely shameful that we hear almost daily of judges/politicians/police officers/priests/pastors, etc...teachers doing this sort of perverted acts on those they have authority and power over. They all deserve, if convicted and found guilty, a DOUBLE sentence because people in authority should be held at a higher standard of conduct. Of course, unless we agree to remove the one character "politician" from the legislation.....you'll find no politician/legislature to pass such a bill.
1 Agrees | 0 Disagrees | Report Abuse »
Finally, it appears SOMETHING we can all agree on for persons GUILTY of such dispicable acts.
Don't hold your breathe though waiting for our leaders to make stiffer penalties for those in authority....and that includes teachers (lately this number is rising dramatically in WV) that take advantage of the ones they have power/authority over.
2 Agrees | 0 Disagrees | Report Abuse »
I cant help but ask where was the supervisors while this lewd act was taking place. Obviously not supervising. Was it a staffing issue? I hear they are short staffed often. Why was this male officer alone with a female Inmate? According to the ****wvrja**** website TVRJ is primarily staffed by female correctional officers. Where were these female officers?
1 Agrees | 1 Disagrees | Report Abuse »
in my personal opinion the blame lies on the shoulders of jail administrator scott villers and sgt micheal wayne. As far as i can tell villers will pretty much hire any one with a heart beat. Maybe if the time was taken to actually research the guards being hired you wouldn't always see stories like this. trust me this isn't the first time this has happened at tvrj. its normally just covered up and the public never knows. 90% of the guards at tvrj a good honest people. its the higher ups that a corrupt and abuse their power.the best part is if an officer wants to do the right thing and report the higher in rank officer. the claim is dismissed and the reporting officer is fired for one bullsh*t reason or another. again in my own personal opinion sgt wayne is a violent sadistic man who abuses his power to the fullest extent. most inmate abuse can be traced right back to him. something needs to change in the regional jail system. the wrong people are in charge.this is again is an opinion
2 Agrees | 1 Disagrees | Report Abuse »
this is to potbelly im this jail guards son i want to her about a story about you on law and order special victims unit watch what you say ok im not to be reckend with
1 Agrees | 1 Disagrees | Report Abuse »
All the opinions on here really don't matter. The truth will come out. And if he's guilty, he should go to prison himself. But if it's true he finally admitted his guilt....then sorry you two posters; he wouldn't be admitting something he didn't do would he?? Sounds like he told on himself if that's true.
0 Agrees | 0 Disagrees | Report Abuse »
Making threats in here doesn't 'help' your case one bit. If you're the father...you're only hurting your son; not helping.
0 Agrees | 0 Disagrees | Report Abuse »
We live in a time where everthing can be recorded. The state legislature should make a law that requires all police personnel to wear body cameras. This would bring the truth out in all situations.
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on November 16, 2012 - 11:38 PM
Lockport diver Paige Kelkenberg was the state runner-up, while Clarence performed well in Friday's NYSPHSAA girls swimming and diving championships in Ithaca.
Kelkenberg finished second behind MacKenzie Moss from Section IV's Chenango Valley with a final score of 455.55.
Section VI finished well in the preliminary round on Friday. Several swimmers are in contention for state championships as the meet continues with a full slate today.
Section VI is still in play for championships in 11 events, including the Clarence relay team, which is the top seed in the 200-yard medley, 200-yard freestyle and the 400-yard freestyle.
Maddie Jacumski, Dorotka Tou, Victoria Butler and Dina Rommell are slated to compete in the 200-yard medley, while the 200-yard freestyle team consists of Rommell, Butler, Rebecca Anthone and Claire Willis. Orchard Park is also in the hunt in the 200 freestyle with Andrea Ernst, Sarah Gura, Grace Coyle and Amanda Ernst. Sydney Modeas anchors the 400 freestyle relay, which includes Rommel, Willis and Anthone.
Modeas is the fifth seed in the 200-yard freestyle while in the 200 IM Olean's Makayla Sargent is fifth while Butler is sixth. Rommel is the No. 2 seed in the 50-yard freestyle while Frontier's Hannah Graesser is sixth. Andrea Ernst is the sixth seed in the 100 butterfly, while Anthone is seventh in the 100 freestyle. Modeas is seeded fourth in the 500 freestyle.
Jacumski is the No. 7 seed in the 100-yard backstroke, while Sargent and Niagara Wheatfield's Marissa Watroba are sixth and seventh in the 100 breast stroke.
Elsewhere, Williamsville East is in the state semifinals in boys soccer and plays Middletown today, while Canisius takes on Fordham Prep in the state Catholic semifinals. In girls soccer, Sacred Heart plays St. Anthony's in the state Catholic semis at Nichols.
In the Class A field hockey semifinals, Williamsville North plays Sachem East at 1:30 p.m. at Cicero-North Syracuse High School, with the winner taking on either Niskayuna or Liverpool at noon on Sunday for the state championship.
Barker plays in the Class C field hockey semis against Southhampton at 9:30 a.m. and the winner plays either Greenwich or Greene on Sunday at 10 a.m. for the title.
The Eden (Class B) and Ellicottville (Class D) girls and Lake Shore boys (Class B) volleyball teams begin pool play in the state semifinals at Glens Falls.


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The best team work ever invented.
" im gonna freakin fail this test , hey gorgeous...can i see your paper? (cheating)
av the walls can hear you 25. april 2007
doing homework, without all of the work and thinking
Making school a hell of a lot easier
av Who The Douce Are You? 16. april 2005
its hurts so much and once you break up and the guy/girl that cheated on you still tells you he loves you, and he has a new gf/bf, and that he's cheating on them, its the worst experience.
i deteste cheating i have no sympathy for those who cheat, but have soo much for those who have been cheated on..
i deteste cheating i have no sympathy for those who cheat, but have soo much for those who have been cheated on..
your a fucking lying, cheating scum
av i.know.your.secrets.you.cunt 22. august 2006
a loser who goes behind your back and does crap with your best friend
Chris is an asshole because he was cheating on Bailey with Cora.
av cmr 28. april 2004
(every single person is capable of this foolish act) it is when you have a significant other but are emotionally or sexually attached to another. reasons may vary on why people choose to committ this act. sometimes your significant other may not be as attentive to you as you would want him/her to be and the person you are cheating with hangs on your every word and act. this behavior causes the person who feels they are being neglected to want more in a relationship and therefore acts on their emotional need. others cheat as a reply to being cheated on. this form of cheating is not always gratifying, because the person doing it usually cheats eratically, it's not thought out and they are simply hurt and wanting revenge. the worst cheaters are the ones who simply cheat because they want to, can and then do. cheating is morally wrong but can definitely make you feel good during the cheating period. it is a selfish act and most of the times you come to your senses after people have been hurt by the act. if you do this to someone you should never get caught, instead come clean and right your wrong.
me and that guy from work were cheating together, i was married and he was engaged to be married. i am now happilly married with the same husband i cheated on and he is married to the unsuspecting woman he cheated on with me. it was an idiotic act that got me a lifetime of what if's. although it's wrong, occassionally i think about him and i even miss him... i wish him well.
av i was wrong 7. august 2008
A creative step toward success.
I started cheating in primary school.
av HuhWhat 2. februar 2006
The Kiss of Death for one's academic career especially if you are in Senior High School/First Year University. Anyone caught tend to be expelled and or blackballed from the college or campus in question... Rightfully so, too.
Cheating on tests is cheating yourself...
av J. Michael Reiter 6. april 2005


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Because the ocean belongs to everyone – and to no one – too many have taken too much. Centuries of overuse and neglect threaten to leave us with a vast blue desert. It is time to change the way we see the ocean – from a place where we take what we want and dump what we don't, to a shared resource of immense value.
WWF is working to generate a new wave of support for sustainable seas. We will show leaders how a healthy ocean fosters economic development. We will celebrate and scale up the work of coastal and fishing communities to protect the resources they depend on. And we'll give everyone the opportunity to speak out for our blue planet. Join us.
Sustain our seas


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SALEM- Since October Smokin' Marty's has embelished its reputation as a top-notch smoke house after co-owner and chef Marty Ciminelli and his wife, Martha, opened a restaurant at 139 N. Ellsworth Ave.
Martha said her husband has catered barbeques for about eight years starting out smoking ribs, pulled pork and brisket in two split 50-gallon drums.
The smoker was deployed for Fourth of July parties.
Article Photos
Marty Ciminelli, right, and his assistant Matt Juillerat work a couple of baby-back rib racks in the smokehouse behind Smokin' Marty's BBQ Restaurant on North Ellsworth Avenue in Salem. The restaurant opened in October with a full menu and has a drive-up pickup window for quicker service. (Salem News photo by Larry Shields)
"Everyone said how good they were," she said and that led to the purchase of a Georigia-made smoker and a first place finish for ribs in a burn-off that also won a fifth-place in the "whole hog category."
Ciminelli said, "That kind of sparked it."
Their son, Marty Jr., was also "bitten by the bug."
The Georgia smoker led to an even bigger rotisserie smoker made in Missouri about two years ago. "With the catering ... and we do a lot of weddings and stuff," Martha said, "we just needed more room (in the smoker)," she said, adding the sauces, ribs and brisket recipes are all Marty's.
Martha is a 1974 West Branch High School graduate while Marty graduated from Salem in 1975. This is the couples first restaurant.
Marty smokes everything in a separate, small fenced-in area behind the restaurant.
He can be found out there in his shorts and jacket in rain, shine, hot or cold with his buddy Scott Brooks and assistant Matt Juillerat who both help out during the four-to-five hours it takes to smoke the racks.
Beef brisket can take eight to nine hours, Ciminelli said, adding it's a process.
"It depends," he said, regarding how oftern he cooks, "on how busy we are. Eventually I'd like to coof every day ... it's getting close (to that)."
The pulled pork takes six to eight hours depending on size and Marty repeatedly coats the cuts with his top secret sauce.
"The glazing makes a difference," he said.
"It enhances the meat," Martha added.
Marty said, "Slow cooked, we do all meat slow ..."
Since the smoking occurs outdoors, Marty said that while the cold weather doesn't bother him it can sometimes lengthen the cooking time.
There is a warming box attached to the smokers for baked beans and baked potatoes. The menu also includes smoked chicken, Brooks said.
"We've cooked in some bad weather," he said, explaining that people driving by on North Ellsworth Avenue and Sugartree Alley wave and some stop and talk.
You know things are running right with Marty in charge.
He's under the canopy where the cherry, oak and hickory wood-fed smoker simmers to a dim orange cooking-glow with18 racks of ribis lined up on two rows like a giant piano keyboard.
The wood burn blends with the ribs and the smoky aroma pouring from the vent has the ability to stop traffic.
And that's partly intended because Smokin' Marty's has a pick-up window on the southside of the building.
Smokin' Marty's is open with a full menu on Monday through Thursday from 9 a.m. until 9 p.m. and on Friday and Saturday from 9 a.m until 10 p.m.
Also popular at the Columbiana County Fair, Smokin' Marty's is on Facebook or customers can call ahead at 330-332-5322 and use the pickup window.


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The former Nickelodeon starlet, 27 – whose lawyer Tamar Arminak told PEOPLE on Wednesday she is "feeling better every day" – was spotted on Thursday, strolling through Thousand Oaks, Calif., alongside her parents Rick and Lynn Bynes with two family dogs in tow.
The recovering actress was casually clad, sporting skinny jeans, Vans high-tops, sunglasses, a baseball cap and a white sweatshirt that said "Gang$ta Love."
Bynes was forcibly hospitalized following a driveway-burning incident in July, but was eventually moved to a Malibu rehabilitation facility.
Moving forward, Arminak said Bynes is "now looking at various colleges with the intention of majoring in fashion design. She's mentioned before she's interested in creating a clothing line."
The actress, who was estranged from her father at the time of her hospitalization, is, according to Arminak, now "very happy to reestablish the loving relationship with her family that she once shared."


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Jack Dempsey/Associated Press file photo
Here�s one that won�t come as a surprise: Peyton Manning writes down his New Year�s resolutions on index cards.
�My dad, since I was a kid, he�s been telling us, �Write them down,�� Manning said.
Though he refused to divulge what�s on those cards or what his lifetime success rate has been with those resolutions, he hasn�t left much doubt about what his day-to-day goals on the football field were for 2012, the year of his comeback.
Work hard. Improve. Keep building chemistry.
Those are the only ways to get to the ultimate goal � winning the Super Bowl, which is something Manning and the Denver Broncos now are favored to do.
Yet to hear Manning tell it, even if the Broncos do win it all, there still will be room for improvement � quite a tall task for a quarterback who compiled some of the best numbers of his career and a team that finished tied for the league�s best record at 13-3.
�I�m not sure you can do it all in one season,� Manning said Wednesday, after the Broncos, the AFC�s top-seeded team, practiced for the first time during their bye week. �I think we�ve done a good job of being the best that we possibly can in this short period of time.�
What began as a season of mystery for Manning � How would his body react after missing more than a year with the neck injury? How would his new teammates respond to him? � has turned into one of his very best campaigns.
He threw 400 completions for 4,659 yards and 37 touchdowns, completed 68.6 percent of his passes and finished with a 105.8 passer rating � all franchise records and ranked second best of the 14 years he�s played in the NFL.
He is in the mix for his fifth Most Valuable Player award, votes for which are being counted this week. On Wednesday, he received his second AFC offensive player of the week honor this year. It marked the 23rd time he�s received that over his career, tied with Tom Brady for most ever.
�To be able to come out and participate like he�s done, to be one of the top quarterbacks in the league, it�s unbelievable,� receiver Demaryius Thomas said. �He had an injury that not many people come back from.�
His latest award came on the strength of a 23-for-29, 304-yard, three-touchdown game against Kansas City on Sunday. The highlights were his touchdowns to Eric Decker and Thomas, who stretched out (in Decker�s case) or up (in Thomas� case) to make one-handed grabs on balls Manning put in places where only they, and not the defensive backs covering them, could catch them.
Were they passes he would�ve thrown to those receivers in Week 1?
�Probably would have thrown them earlier, not sure if we would�ve completed them,� Manning said. �It�s hard to say. But there�s no question, it would be just downright disappointing if we had not improved throughout the season.�
Manning, however, doesn�t judge improvement simply on completions or any other numbers on the stat sheet.
It�s a much more intangible thing to him.
Take the touchdowns against Kansas City. Manning said neither he nor the receivers had seen the kind of coverage the Chiefs were in on those plays until Sunday, the last week of the NFL season. The next time they see it, though, they�ll have a readymade reference point.
�So if you play together long enough, then you can say, �Hey, remember Kansas City in 2012? Remember that? Oh, yeah,�� Manning said. �I�m not going to have that much eligibility to be able to refer back too long, but those guys certainly will. It�s been kind of like cramming for a test, and I think both of those guys have put in the time to cram, and we�ve really worked hard in the short time we�ve had together.�
In fact, it�s the chemistry he�s built with Thomas, Decker and the rest of the receivers that Manning lists as one of his most pleasant surprises this season.
�The rapport with the receivers has come probably quicker than I thought,� he said. �I really didn�t know on some of the timing routes, some of the adjustments and things.�
It�s not to say flaws don�t exist, but �I don�t think it makes any sense to reveal those things with a game coming up.�
Indeed, it�s now time to make the best of the hand they�ve got.
In Denver�s case, it�s a pretty good hand.
�There are still things that I wish would be better, and I think you kind of have to pick and choose your battles,� Manning said. �It�s, �Hey, we�ve only had 16 games together, we�re not going to be able to fix that. But let�s try to get really good at this. Let�s be as good as we can at that.� Some things just take time.�


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Celebrities are showing Ellen Page that all you need is love.
Following her surprise announcement that she is gay while addressing the audience at the Time to THRIVE conference in Las Vegas on Friday, Twitter immediately started buzzing as Hollywood stormed social media to offer its support to the 26-year-old Oscar-nominated actress.
And their overwhelming outpouring of love didn't go unnoticed. According to Twitter analytics released by Topsy, "Ellen Page" has been Tweeted more than 192,000 times since her announcement.
Page heard the positive response, retweeting several supporters on her Twitter page and even responding to actress Kate Mara's sweet proposal. "Hey @EllenPage...Be my Valentine?" Mara wrote, to which Page replied, "Yes please."
Mara wasn't the only one to shower the Juno star with praise: Ricky Martin, Mia Farrow, Jesse Tyler Ferguson and more Tweeted out encouraging messages. Here's a round-up of what the stars are saying.
Ellen Page Comes Out: An Outpouring of Support on Twitter
Nina Prommer/EPA/Landov
updated 02/15/2014 AT 07:40 PM EST
•originally published 02/15/2014 AT 01:40 PM EST


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1511 Druid Rd.
Inverness, FL 34452-4507
Phone: (352) 726-2357
Mon - Thurs 10:00am - 7:00pm
Fri - Sat 10:00am - 5:00pm
From our Community Partners Blog
If you aren't familiar with Medicare or the other available resources, or if you just want to brush up on what you already know, SHINE... Read more
From our Community Partners Blog
Seven events will offer visitors an opportunity to participate in guided evening walks The Friends of the Crystal River Preserve State Parks, Inc., in partnership with... Read more
From our Community Partners Blog
Citrus County Parks & Recreation's P.L.A.Y. ProgramThe P.L.A.Y. program (Preparing Little Athletes Youth) is a comprehensive motor skills development program that will prepare you and... Read more
From our Community Partners Blog
Staff Assisted Services Schedule and Locations CareerSource will roll out its Mobile Resource Unit (MOBY1) to the Homosassa Public Library to help residents of Citrus County find... Read more
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Please join BJ Jarvis, from the UF IFAS Extension on for her program, "Culinary Herbs - Growing and Cooking." Discover the many flavorful herbs well-suited... Read more
The Citrus County Library System will promote the pursuit of knowledge and deliver quality education to the community, embracing the power of information, imagination, and ideas.


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on February 23, 2013 - 5:43 PM
MALL WALKS: The Wellness Institute and its community partners are offering Winter 2013 Be Active Erie County walks for older adults at area malls. Registration for the first walk begins at 8:30 a.m. Friday in the food court of the Boulevard Mall, Maple Road and Niagara Falls Boulevard, Amherst. The walk begins at 9:15 a.m. Participants have a choice of guided walks – long or short. Also offered are health education materials, health/fitness screenings, presentations, healthy refreshments and an opportunity to meet new people and socialize with old friends.
DANCE MARATHON: The Western New York chapter of the Alzheimer's Association will host is first 18-hour Dance Marathon, from 6 p.m. Friday, through noon Saturday in Sinful Nightclub, 334 Delaware Ave. Dancers age 17 and older must register by Wednesday at www.stepupforalz.com. The registration fee of $20 includes free swag bags. Doors open at 5 p.m.
WORKSHOP: Cornell University Cooperative Extension will hold its annual Rural Landowner Workshop from 9 a.m. to 3 p.m. Saturday in Pioneer Central School, County Line Road, Yorkshire. The workshop involves several agencies that provide educational information and outreach to landowners. For more information or required preregistration, call 585-268-7644, Ext. 10.