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CHICAGO - Many people believed Penn State's recruiting would suffer immensely with the NCAA sanctions, but coach Bill O'Brien sounded very optimistic about that issue Thursday.
"Recruiting has gone well for us," the coach said.
Not only did star recruits such as Christian Hackenberg and Adam Breneman remain committed to Penn State this year, the program is doing well for 2014 and beyond.
"We believe that we're ahead of the game for the '15 and '16 classes," O'Brien said, referring to young prospects his staff has already targeted.
O'Brien noted he spends time every day thinking about recruiting and how to divvy up the 15 scholarships Penn State is limited to each year through 2017. He feels good about the overall talent the program is attracting but noted depth at each position will remain a major focal point because of the scholarship limits.
O'Brien joked that guard John Urschel, a math whiz, should be helping figure out the scholarship numbers.
One area O'Brien said must improve is recruiting in Ohio.
"There's a lot of Division I players in Ohio, and they can't all go to Ohio State," he said.
Despite the sanctions, O'Brien said it can be invaluable just getting a recruit on campus because "it's such a fantastic place."
O'Brien praised the coaches on his staff, saying they're all "solid recruiters."
One aspect he wants them to work on is doing better background checks so they get to know the players better. That comes on the heels of former recruit Zayd Issah getting arrested twice.
News and notes
Some of the many topics O'Brien addressed during his two-hour media session Thursday:
n He was asked for the first time about Aaron Hernandez, whom he coached with the Patriots. "That was sad. I was sad. Any time you coach a guy and he's involved in a murder investigation, that's a sad day."
n Urschel received a standing ovation from more than 1,800 people after giving a speech during Thursday's kickoff luncheon. O'Brien called Urschel "a shining example of what college athletics is all about.
n Zach Zwinak remains the first-string tailback entering camp, even though he's not fully recovered from a left wrist injury in the Blue-White Game. When discussing how Zwinak fumbled too much last year, O'Brien joked that he would have him carry a ball around campus, like in the movie "The Program."
n Running back Bill Belton is focusing on academics this summer and not doing much football work, and O'Brien said he does believe Belton will be eligible this season. For Belton to become a better runner, the coach wants him to "don't dance, one cut, go."
n Running back Akeel Lynch really wanted to play last year as a true freshman, but O'Brien said he understood that it was best for the program if he redshirted.
n There are 66 scholarship players and close to 40 run-ons.
n O'Brien said the Sports Illustrated article that brought up ethical questions about trainer Tim Bream was "absolutely ridiculous." He added, "I just think the world of Tim Bream."
n The coach would like to be able to redshirt as many freshmen offensive linemen as possible since he believes it's greatly beneficial at those positions. He also said he likes to decide who will redshirt after the first three games.
n O'Brien said receiver Alex Kenney has had a "really good offseason."
n The legend of strength coach Craig Fitzgerald continues to grow, with O'Brien saying he does his personal workout at 3:30 a.m.
n O'Brien does keep a short list of potential assistant coaches should anyone on his staff leave. If a coach does leave for a better opportunity, he said, "That's good for your program."
n Safety Malcolm Willis said Penn State still gets motivation from being an underdog story, and O'Brien says that's only natural. "There's still a lot of that mentality because of the situation we're in. We're not on an even playing field," he said.
n O'Brien still has a great relationship with Matt McGloin and feels fortunate to have inherited a quarterback who had a lot of playing time.
n Defensive end Deion Barnes tweeted recently that he believes college football players should be paid. "It's a free country," O'Brien said of that. "He's entitled to his opinion."
n O'Brien said he hates Twitter but doesn't want to go down the road of banning it for his players. He wants them to "be careful before you hit send."
n O'Brien is aware of the popular Twitter personality Evil Bill O'Brien, who tweets angrily and comically as the coach's alter ego. "I think Evil Bill needs to tone the rhetoric down," the coach said with a laugh.
n O'Brien has great respect for Michigan coach Brady Hoke, mentioning him several times the past two days and calling him "one of the best coaches in the country." He said he and Hoke share similar philosophies in building a program, wanting "tough guys, smart guys, good guys."
n O'Brien is impressed that the SEC has won seven consecutive national titles, saying, "Right now there's no doubt that they're the king of the hill." He went on to add he believes things are cyclical in college football and that, "Eventually the Big Ten will come back and be in the hunt."
n The coach wants to see more night games in the Big Ten and said he hasn't been able to find the supposed rule limiting night games later in the season. He loves the atmosphere of night games at Penn State.
n O'Brien doesn't talk to his players about the controversial Joe Paterno stuff but does plan to teach them more about the history of the program.
n He's recognized locally in central Pennsylvania, but O'Brien joked, "When I go home to Cape Cod nobody knows who the hell I am." He can't understand why people want to pose for pictures with him, saying, "Do they actually put that picture on their mantle? Who would ever put a picture of me [up]?"


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Beyond the pomp and circumstance,
High seniors got an impromptu concert at graduation Saturday morning — from
their principal.
Dr. Charles Wagner recalled a guitar he received as an
11-year-old to illustrate a message of giving to others, then gave his graduates
a surprise gift: strumming that same guitar while singing Green Day's "Good
Riddance" (aka "The Time of Your Life").
With that Wagner bid goodbye to WJCC Schools (he'll be an assistant
superintendent in Gloucester) and to one of the most academically competitive
classes in school history.
Forty students entered the spring semester with a GPA of 4.0 or higher, and the
class valedictorian wasn't settled until the day before
Senior speaker Maggie Underwood told her classmates,
"Achievement is part of our nature. The talent and passion sitting in front of
me is monumental. Don't just be a big fish, but a full-on sea
Full article at Daily Press: HERE

subset: commoncrawl


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When battlefield nurse Bess Crawford returns from France for a well-earned Christmas leave, she finds a bruised and shivering woman huddled in the doorway of her London residence. The woman has nowhere to turn, and, propelled by a firm sense of duty, Bess takes her in. Once inside Bess's flat the woman reveals that a quarrel with her husband erupted into violence, yet she wants to go home if Bess will come with her to Sussex.
What Bess finds at Vixen Hill is a house of mourning. The woman's family has gathered for a memorial service for the elder son who has died of war wounds. Her husband, home on compassionate leave, is tense, tormented by jealousy and his own guilty conscience. Then, when a troubled house guest is found dead, Bess herself becomes a prime suspect in the case. This murder will lead her to a dangerous quest in war-torn France, an unexpected ally, and a startling revelation that puts her in jeopardy before a vicious killer can be exposed.
"Makes fine work of the brooding atmosphere."
-New York Times Book Review on A Bitter Truth
-Publishers Weekly (starred review) on A Bitter Truth
"Bess is a very strong series lead, the historical setting is as well developed here as it is in the Rutledge books, and the mysteries are just as elegantly constructed. Readers who have yet to sample the Crawford series should be strongly encouraged to do so."
-Booklist on A Bitter Truth
"Few writers surpass Todd in depicting the insanity of war."
-Kirkus Reviews on A Bitter Truth
"Todd brings World War I England and France to life with an intriguing plot and an intrepid sleuth."
-Library Journal on A Bitter Truth
"A thoughtful mystery with an excellent plot, well-drawn characters and wonderful atmosphere."
-Associated Press on A Bitter Truth
"A well-envisaged plot, a deep sense of time and place and characters drawn with care and compassion."
-Richmond Times-Dispatch on A Bitter Truth
"Charles Todd has developed believable characters that carry along this story with lightning speed from the first page to the last."
-New York Journal of Books on A Bitter Truth
"The Todds excel at complex characterizations....For lovers of upper-drawer British whodunnits and Anglophiles in general, A Bitter Truth should prove a sweet treat indeed."
-Wilmington Star-News on A Bitter Truth
"A lovely picture of a slower world."
-Charlotte Observer on A Bitter Truth
"A thoughtful mystery with an excellent plot, well-drawn characters and wonderful atmosphere."
-Indianapolis Star on A Bitter Truth
"Combines believable characters, gut-wrenching suspense and a sobering commentary on the ravages of war."
-Deseret News on A Bitter Truth
"Highly recommended—well-rounded, believable characters, a multi-layered plot solidly based on human nature, all authentically set in the England of 1917, make A Bitter Truth an outstanding and riveting read."
-Stephanie Laurens, New York Times bestselling author
"Readers will enjoy Todd's plucky, determined sleuth and a thrilling mystery that proves murders on the home front don't stop just because there's a war."
-Library Journal on An Impartial Witness
"Bess Crawford is a strong and likable character."
-Washington Times on An Impartial Witness
"A superb whodunit—just when you think you have it figured out, Todd throws a curve—and a moving evocation of a world at war."
-Richmond Times-Dispatch on An Impartial Witness
"A smartly plotted, well-told mystery."
-Booklist on An Impartial Witness
"A book rich in atmosphere and dense with plot."
-St. Louis Post-Dispatch on An Impartial Witness
"Todd's excellent second mystery featuring British nurse Bess Crawford smoothly blends realistic characters with an intricate plot."
-Publishers Weekly (starred review) on An Impartial Witness
"Find some cures for the post-Downton Abbey blues ... Charles Todd has been producing a series of highly praised detective novels set in the years immediately after World War I."
-Tulsa World Scene


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Live In Asbury Park Volume 2
Clarence Clemons - Temple of Soul: Live in Asbury Park, Volume 2 featuring his biggest hit single "You're a Friend of Mine" and "Raise Your Hand" with Bruce Springsteen on lead vocals and lead guitar.
Availability: In stock.
Product Description
|Clarence Clemons is one of the most famous and best loved saxophone players of our time. His sax solos are instantly identifiable to millions of fans of rock and roll and Clarence is one of the best known performers of our generation thanks to his television and movie appearances and his touring with the E Street Band. This cd features his biggest hit single "You're a Friend of Mine", "Raise Your Hand"(with Bruce Springsteen on lead vocals and lead guitar), and his other well known songs.
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Top Definition
The name of a boy who is simply amazing. He is the kind of boy that all the girls want. He is super sweet. The sound of his voice will put you at ease. The way he says your name will make you melt inside. He is super talented at everything he does. He is smart and witty. He listens really hard to what you have to say. He never judges you. He is damn sexy and handsome. His jokes make you smile. He can be a butthead sometimes, but you will still love him. ;) He is the most perfect boy in the world and you will never ever ever find another guy like him.
MY boyfriend, Alam, is my soulmate.
di coop6293 10 dicembre 2010
Trending Now
Can you define these popular missing words?
The name of a boy who is very intelligent. Who likes very nerdy things like pokemon and star wars. But not only does he have brains but he also has the biggest heart. He can be such a sweetheart that u want him to be yours. When he is yours u feel like the luckiest girl ever. Very ideal for a boyfriend. Isn't the hottest guy ever but he definitely has good looks. Can be very perverted. Can also be the best guy friend u can ever have. Very supportive and a great listener. Not necessarily a leader but not a follower either. Someone who is unique so this definition may not be accurate because everyone is unique in their own way.
Alam Monsivaiz
di Gracy Stacy 10 marzo 2012
alam; #alam : hashtag standing for AlwaysLikeAMovie. Tag moments and pictures of your days lived like Dan Bilzerian but without pussies and bentleys and cats and guns. Non-douche non-fag version of YOLO.
receiving a head meanwhile driving after a non-sense roadtrip. #alam
when you cant wait to be ashamed of what you did this weekend #alam
when you cant wait to be ashamed of what you did this weekend #alam
di nicptr 08 luglio 2014
To destroy the cosmetic appearance of an inanimate object without compromising its operational integrity.
I just alam'd the toilet!
di jzbomb 04 ottobre 2011
The smallest measurable unit of caring. An alam is to a rat's ass as a rat's ass is to exuberance.
"I couldn't give an alam about going to that baseball game."
di Alan Richards 28 agosto 2007
a very nice girl. who hate gupz some times
she is very kind
di punjabi 23 marzo 2003
Alam is of Arabic origin. It means the world or universe.
What does Alam mean?
The world or universe.
The world or universe.
di EinsteinKnowledge 08 settembre 2016


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KEN wrote: Walker has told us all he balanced the budget. He took the money from the poor and middle class, but he did say he balanced the budget.
KEN wrote: taking away the rights of the middle class
River Rat wrote:Ironicly, I would support bringing it back, but only if serious reform occured. If the politcal ties were truly severed, membership and dues were volintary, and the union's only focus was the worker, I think the issue would have much more support.
Kerry Tobin wrote:employees have to vote to unionize first
Kerry Tobin wrote:And last point. Stop saying it was filtering public money to to PACs. The moment that employee EARNED the money, it became theirs. Their money was diverted, not yours!!! No part of anything on my paycheck belongs to you or anyone else (other than the taxes). I find it offensive that you would even begin to consider it otherwise!
Kerry Tobin wrote:River Rat,
I don't think you're reading my response. If you get a job at a union private business, you are typically required to join the union. The union actually has a court backed ability to fine you for going against a union strike, etc.
You said the unions forced employees to join in Wisconsin public unions. I was simply pointing out that that was not an unusual situation and probably not any different than the paper mills or Harley.
Few municipalities and no Wisconsin school boards have civil service ordinances, said Andrew Phillips, a lawyer for the Wisconsin Counties Association.
Currently, unions often negotiate work rules in contracts that are specific to widely varied workplaces such as prisons, Department of Natural Resources offices and schools, while civil service rules are "one size fits all," said UW-Madison emeritus professor Dennis Dresang.
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LEWISTOWN - As a pastor's son, Josh Nuss grew up surrounded by Bible teachings and church services.
But it was not until he attended youth group in high school that his relationship with God became real.
Nuss, the new assistant pastor at Grace Covenant Church in Lewistown, said those nights at youth group in New York inspired him to become a youth pastor.
Article Photos
Sentinel photo by MICAIAH WISE BILGER
Josh Nuss is the new assistant pastor at the Grace Covenant Church in Lewistown.
At the heart of his ministry is a desire to acquaint youth with the same relationship he found in God.
" ... in youth group, (my faith) became my own - not just my parents' faith but my own," Nuss said.
Since he moved to Lewistown in May, Nuss has been active with the youth of the church, leading groups and building relationships. He also assists Senior Pastor Ron Neff with pastoral care visits and teaching, and serves on the worship team.
The Lewistown church is his first staff position, though he served in several churches and with a mission while he studied at Elim.
Rev. Neff said the church has been searching for an assistant minister for several years.
"We don't just fill the position," Neff said. "It's got to be a right fit. God connected us with Josh here. It has been a wonderful connection."
The young pastor said he enjoys the rural community. It won't be too long before he will have a new partner in ministry - Nuss is engaged to be married to a young woman who also attended Elim.
Nuss said he really wants people, especially youth, to know they can have a personal relationship with God.
"There's freedom in Christ," Nuss said. "He can set them free from bondage."
His focus for the church youth meetings is more than just fun - though that is important, too. Nuss said he hopes to lead the youth toward building healthy relationships with the leaders and peers, and, most importantly, to grow closer to God.
Youth and young adult groups meet on Wednesday, Saturday and Sunday evenings. Nuss also participates in worship services, which are held at 10 a.m. Sundays and 7 p.m. Wednesdays.
For more information, call the church office at 248-4579 or go online to www.gcclewistown.com.


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Mastercard identity (2016)2016
- Pentagram
- Michael Bierut
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Contributed by Stephen Coles
Citi Bike – The First 100 Days website2013
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on November 14, 2012 - 11:36 PM
, updated November 15, 2012 at 4:47 PM
1. Free C.J.!
The Dolphins had not allowed a 100-yard rusher for 22 straight games – the longest such streak in the NFL – until they met up with Tennessee's Chris Johnson last Sunday. He gashed Miami for 126 yards and a touchdown in a blowout win for the Titans. In C.J. Spiller the Bills have the perfect player to clone that performance. Johnson's biggest runs against Miami came on cutback plays, in which the Titans' offensive line would flow one way and Johnson would burst through a hole on the back side. There isn't a player in the league who's more adept at making guys miss than Spiller, whose average of 4.3 yards after first contact leads the NFL, according to Pro Football Focus. Spiller will have to work for it. The Dolphins' run defense is fifth in the league, allowing 94.2 yards per game. With Fred Jackson out because of a concussion, Spiller should get at least 20 carries tonight.
2. Force a turnover, any turnover.
When Marcell Dareus tipped Tom Brady's pass into the air on the Patriots' first possession Sunday, it looked like the Bills would finally record a takeaway for the first time in three games. Only it didn't happen. The ball somehow eluded linebacker Bryan Scott. Cornerback Leodis McKelvin later had a would-be interception in his hands on the same drive, but also dropped it. For the season, Buffalo is minus -10 in turnover differential, which ranks 30th in the league. Dolphins rookie quarterback Ryan Tannehill has mostly done a good job protecting the football, but had a streak of 107 straight passes thrown without an interception snapped against the Titans, on his way to three picks. Tannehill has particularly struggled on third down, with an AFC-worst passer rating of 52.6 and six of his nine interceptions.
3. Pick on Miami's third and fourth corners.
The Dolphins' third cornerback, Jimmy Wilson, is a converted safety forced into duty after Richard Marshall went on injured reserve last week. Wilson has been targeted 12 times in the past two games, according to Pro Football Focus, and given up 10 receptions for 116 yards and a touchdown. R.J. Stanford, the team's fourth cornerback, has played in just 6 percent of Miami's defensive snaps. The Bills would do well to line up Donald Jones, who has a team-leading 19 targets over the past two weeks, in the slot to take advantage of those matchups.
4. Bottle up Reggie Bush.
The Dolphins' primary runner, Reggie Bush, has had success against the Bills in his career, averaging 5.6 yards per carry against Buffalo. But Bush was benched against Tennessee last week following a first-quarter fumble and Miami rushed for just 54 yards. Miami's rushing attack has slipped from second in the NFL after Week Two to 19th since then. If the Bills can persuade Dolphins coach Joe Philbin to bench Bush again, it will make Miami more one-dimensional. That in turn could open up opportunities for defensive end Mario Williams against Dolphins rookie right tackle Jonathan Martin, who has allowed 24 quarterback hurries.
5. Take advantage of the scheduling.
The NFL's expanded Thursday schedule has not been favorable to road teams. Through the first nine Thursday games, home teams are 6-3. Two of those losses by home teams were the lowly Panthers and Jaguars, who have combined for three wins this season. The short turnaround is quite a bit to ask for road teams when you consider the Dolphins will spend more time flying to Buffalo than they will practicing for Thursday night's game.
Outlook: This is no longer the slam dunk it was when the schedule first came out, but it's still a game the Bills can win. With a national TV audience watching and their season on the line, the thinking here is they will.
Prediction: Bills 27, Dolphins 20.


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Poker (Card Game)
News about Poker, including commentary and archival articles published in The New York Times.
New York State Considers Further Expansion of Once-Illicit Activities
Mixed martial arts, online poker and other activities appeal to Gov. Andrew M. Cuomo and many legislators as sources of revenue.
March 23, 2016, Wednesday
MORE ON POKER (CARD GAME) AND: Mixed Martial Arts , New York State , Gambling , State Legislatures , Cuomo, Andrew M , Alcoholic Beverages , Law and Legislation , Casinos , Fantasy Sports , Poker (Card Game)
Using Card and Board Games to Keep Minds Sharp
Organizations for chess, bridge and poker fill social and competitive needs for older adults.
December 5, 2015, Saturday
MORE ON POKER (CARD GAME) AND: Retirement , Cards and Card Games , Games , Poker (Card Game) , Chess , Bridge (Card Game) , Elderly
DraftKings Cuts Its Ties With Top Poker Series
DraftKings has moved to distance itself from poker after questions have been raised about whether the daily fantasy sports industry should be considered gambling.
October 24, 2015, Saturday
MORE ON POKER (CARD GAME) AND: DraftKings Inc , Fantasy Sports , Poker (Card Game) , Gambling , World Series of Poker , Regulation and Deregulation of Industry
The Perfect Predictability of Gambling Movies
They're irresistible not because we want to find out how they end, but because we already know.
October 5, 2015, Monday
MORE ON POKER (CARD GAME) AND: Cards and Card Games , California Split (Movie) , Rounders (Movie) , Mississippi Grind (Movie) , The Cincinnati Kid (Movie) , The Hustler (Movie) , Casinos , Movies , World Series of Poker , Gambling , Poker (Card Game) , Altman, Robert , Mendelsohn, Ben (1969- ) , Newman, Paul , Reynolds, Ryan
Alexis Tsipras's Aggressive Game of Poker Pays Off, for Now
The Greek prime minister got a somewhat better deal by risking it all, but he may want to choose his bluffs more carefully from now on.
July 11, 2015, Saturday
MORE ON POKER (CARD GAME) AND: Greece , Tsipras, Alexis , European Sovereign Debt Crisis (2010- ) , Europe , Eurozone , Poker (Card Game)
A Computer That Knows When to Hold 'Em
Scientists have developed an algorithm that guarantees at least a draw in one variation of poker.
January 13, 2015, Tuesday
MORE ON POKER (CARD GAME) AND: Poker (Card Game) , Computers and the Internet , Science (Journal) , Bowling, Michael
From 2,500 Miles Away, an Online Gambling Push for New York
The organizer behind the social media drive Let NY Play is MGM Resorts International in Las Vegas, which has made no secret of its ambition to be a big player in Internet gambling.
October 14, 2014, Tuesday
MORE ON POKER (CARD GAME) AND: Gambling , New York State , MGM Resorts International , Computers and the Internet , Poker (Card Game) , Casinos , Bonacic, John J , Adelson, Sheldon G , Atlantic City (NJ)
Harry Truman, Five-Card Stud and the Cold War
The metaphor of poker was used by many presidents, but Truman was the one most publicly identified with the game.
September 20, 2014, Saturday
MORE ON POKER (CARD GAME) AND: Presidents and Presidency (US) , Truman, Harry S , Poker (Card Game) , Cold War Era , United States International Relations , United States Politics and Government
Art of the Deal: A Broker Who Knows When to Go All In
For Julie Zelman, the players sitting around the poker table have proved even more lucrative than the pot in the middle of it.
July 8, 2014, Tuesday
MORE ON POKER (CARD GAME) AND: Real Estate Brokers , Poker (Card Game) , Real Estate and Housing (Residential) , Zelman, Julie , New York City , New Jersey , Casinos
Five-Card Studs
In their new memoirs, Colson Whitehead and Brooks Haxton use poker to expand our sense of how human beings work.
June 1, 2014, Sunday
MORE ON POKER (CARD GAME) AND: Haxton, Brooks , Poker (Card Game) , Books and Literature , Whitehead, Colson
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"Food and eating are two of my favorite things. In fact, those are two of the reasons I became a registered dietitian."
from the looks of her food journal, it seems like she hates food. is she punishing her diet for a reason? skim milk with her cereal? ground turkey in her stir-fry? gross! reading this made me hungry. even if i were still on the conventional diet i find her food journal seriously lacking in... well, food.
to think that this is the example we're supposed to follow!


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An opinion piece in last week's "Your Lowcountry" section posed the question, "Does anyone truly love the old county library building?" At the risk of inviting calumny from friends and neighbors, the answer is "Yes. I do." I love 404 King St. because its architectural elements are inseparable from the wonderful experiences I had many years ago in its Children's Room.
Under the guidance of Miss Madeline Mosimann, the children's librarian from 1964-77, I developed wide-ranging literary tastes and an enduring love for books. I have had the occasion to study and even to work in some magnificent libraries. But the sense that anyone, anywhere, can learn anything in a library was awakened in me through a caring and beloved librarian at 404 King.
To pull into the unpaved parking lot, jump out and run up the flagstone walkway and straight back into the Children's Room always felt like a homecoming. Miss Mosimann would materialize, a smile wreathing her face, and in her hand a volume she thought I would like. In the summers, armed with my school reading list and a few suggestions from Miss Mosimann, I would pile books into my arms and head for the nearest hammock.
To my eight-year-old eyes, the pink marble streaked with gray was beautiful and even exotic, different from anything else I knew in Charleston. The curtain walls were distinct from the stately 18th and 19th century houses of my neighborhood.
The architecture signaled that the library was a special place. The glass walls, the open spaces that housed the quiet bustle, the welcome that was extended to every person — this was what a library was.
I was unaware of the controversy over the building's funding, design and construction. I didn't know that someone had labeled my beloved library a "pink marble monstrosity." And I was oblivious to the fact that the library was one of Charleston's first public facilities to welcome black and white, as the library staff fulfilled their vocation to provide access to all.
Now that I am an adult, I still love the library building. It's partly a nod to memory. But I also believe that the building has a place in the broad spectrum of Charleston's architectural history. It may be hard to love the federal building on Meeting Street, or the College Lodge on Calhoun, or even 404 King St., but these buildings represent important moments in Charleston's architectural timeline: the arrival of the Modern movement, embodied in local architects such as Augustus Constantine, Samuel Lapham and C.T. Cummings (who designed the library).
Because of what 404 King St. stands for, namely — both architectural and cultural progressivism — its fate deserves more thought. One man's beloved icon may be another's pink marble monstrosity, but the old library building is a landmark and deserves protection.
The executive director of the Preservation Society (on whose board of directors I serve) has suggested that 404 King be re-purposed as the Clemson Architectural Center, with a rooftop garden and café, well suited to the new vibrancy of upper King. It also ties nicely into the Clemson Architecture program, which was an early proponent of the Modern movement in South Carolina in the early-to-mid-twentieth century.
Preservation efforts in Charleston have always been about finding a balance between retaining the old and developing the new. The former library building, while not old by Charleston standards, occupies a special niche in the city's architectural and social history.
Surely we can find a better way to honor that history than with a wrecking ball.
Ladson Street


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Charles Richard Baum Jr., 86, of Colona, died Tuesday, Sept. 18, 2012, at Illini Restorative Care Center after a long illness. Funeral services celebrating his life will be held at 10:30 a.m. Friday, Sept. 21, at the Colona United Methodist Church, 1709 Cleveland Rd., Colona. The Rev. Sandy Bunnell will officiate. Burial will be in Colona Township Cemetery. A visitation will be held from 4 p.m. to 8 p.m. Thursday, Sept. 20, at Vandemore Funeral Home Ltd., Geneseo. In lieu of flowers, the family requests memorials may be left to the Colona United Methodist Church or the Catfish Jazz Society Scholarship Fund.
He was born on Feb. 26, 1926, in Geneseo, the son of Charles R. Baum and Reenste (Heeren) Baum. He grew up on the farm in Colona and moved as a young child to a farm west of Geneseo. He was a musician and entertainer from his early days, playing clarinet and tap dancing for county meetings and state gatherings. He was always accompanied on the piano by his mother. He graduated from Geneseo High School and joined the U.S. Army and was a member of the U.S. Army band during World War II. Charles married Darlene Scherer of Rock Island and they began farming in Colona and Geneseo in 1948.
He enjoyed life to the fullest, serving on the Henry County Board of Supervisors, The Bi-State Planning Commission, Black Hawk College Board, Henry County Health Improvement Association and Illinois Blue Cross Blue Shield Board of Directors. He was one of the founding members of the Henry County Bank. Charles was a member of the Henry County Pork Producers and Illinois Pork Producers. He served on the Illinois State Fair Board. He and Darlene enjoyed a full life, loved people and entertaining, even having an opportunity to host, in 1980, then candidate for vice president, George Bush, at the farm. In his retirement, he joined the Catfish Jazz Society, volunteered for the Bix Beiderbecke Festival and played with a number of music groups locally and in Florida. Music was his great gift and great love.
Survivors include his wife, Darlene; one son and spouse, C. Richard and Nancy Baum III of Geneseo; one daughter, Lisa Baum of Iowa City, Iowa; four grandsons and spouses, Daniel A. and Emily Baum of Geneseo, Mitchell J. and Kristin Baum of Ames, Iowa, Brent B. Waters of Solon, Iowa and Vincent L. Waters of Tipton, Iowa; and four great grandsons, Clayton, William, Maxwell and Jacob Baum. He was preceded in death by his parents.
Location, ST | website.com


text: Mongolian camels have no problem with the cold because of their thick fur, and they radiate cozy warmth when one rides on them, as one does for instance during the special sightseeing tour at the foot of the Chasseral. The tour ends with a fondue meal on a farm. Since small children might slide down camel backs, they are given ponies to ride. And now let's set off on the caravan tour!


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Sending VoteClick to Vote47%Carol Burnett
Sending VoteClick to Vote18%Nick Jonas
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- 'Sabrina, the Teenage Witch' premiered 20 years ago! Which character in the Spellman household was your favorite?
- Hit singers took to Vegas for the iHeartRadio Music Festival over the weekend. Which star had the best festival-ready look?
- It's time for fall movies! Which new flick out this weekend is at the top of your must-see list?
- September 22 is a popular day for shows to premiere. Which show sharing this premiere date anniversary is your favorite?
- Mariah Carey's 'Glitter' turns 15! What's your favorite pop star-led flick?
- TV stars stunned in colorful dresses at the 2016 Emmys. Which actress had the best look of the night?
- Whatever genre movie you're in the mood for, the new films out in theaters today have you covered. Which flick will you be checking out first?
- The CW's The Secret Circle premiered five years ago today. Which one-season CW series do you most wish lasted longer?


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The University of South Carolina's School of Hotel, Restaurant & Tourism Management of the College of Hospitality, Retail, & Sport Management invites applications for the position of Assistant, Associate or Full Professor to work with the International Institute for Foodservice Research and Education (IIFRE). The School serves over 700 students, 400 minors, 30 master's students and a new Ph.D. program. It employs 15 full-time faculty and a number of distinguished adjunct faculty.
The Assistant, Associate or Full Professor will work directly with the Director of the International Institute for Foodservice Research and Education to obtain grants and research funding as well as to perform foodservice related research within the School of Hotel, Restaurant and Tourism Management. Some examples of research expertise could be broadly related to: obesity, health and wellness, behavioral economics, food safety, and nutrition. The IIFRE is dedicated to the advancement of foodservice and hospitality education through research, curriculum development, executive training and consultation.
This new faculty position will be responsible for excellence in research, teaching, service, and the pursuit of grants or contracts. The successful candidate must have evidence of or potential to develop an extramurally funded research agenda, be able to demonstrate a record of successful research and grant achievement, and a commitment to quality teaching. Evidence of ability or promise to obtain external funding is required. In addition to demonstrated research and grant achievement, candidates must possess an earned doctorate in hospitality management or closely related area and a distinguished record of scholarly and professional achievement. Experience in working in or with a research center or institute at a college or university is desirable.
The review of applications will begin October 1, 2012 and will continue until the position is filled. In order to apply, please submit a letter of intent, curriculum vitae, and statement of teaching and research interests online on the University of South Carolina Human Resources website at https://uscjobs.sc.edu. The requisition number for the position is 004274. Please provide three letters of reference sent directly to Mary McDaniel, HR Manager, College of HRSM, Carolina Coliseum Room 1000, Columbia, SC 29208. Start date for the position is August 16, 2013.
If you have any questions or would like additional information, please contact the search committee chair, Dr. Robin DiPietro, at 803-777-2600 or email@example.com.
The University of South Carolina is an affirmative action, equal opportunity employer. Minorities and women are encouraged to apply.
The University of South Carolina is responsive to the needs of dual career couples.


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Bob Ellis has been an active member of our Truckee community for more than 20 years. His engineering background brings a technical view to operations, and his 10-year experience as president of the Far West Ski Racing Association, along with leadership positions in several additional community organizations, brings his proven leadership skills to the table.
Our TDPUD faces new challenges every day as environmental and cost issues continue to change. It is the responsibility of all Truckee citizens to protect this unique recreational and residential community. Bob has the knowledge, beliefs and leadership skills to positively add to the management of our TDPUD. Please add your vote to the support of Bob Ellis.
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BELOIT - The West Branch varsity roster boasts seven seniors, with the only non-senior listed being sophomore Kip DeShields. After Friday, the Warriors might have to expand the list.
West Branch used their experience coupled with a strong bench to cruise to an 85-35 victory over United.
"I think we wore them down," West Branch head coach Lou Sellaroli said following his first win as Warriors head coach since his previous stint from 1998-2003.
"We are trying to get up and down the floor a little bit more, and we are trying to press a little bit more they made us look sloppy at times, but I think we went on a run in the third quarter."
The Warriors lead hovered around 25 for much of the game, but they led by as many as 56 late in the fourth.
West Branch came out running from the opening tip, taking a 15-point lead after four and a half minutes with a 17-2 run to start the game. Jacob Griffith paced the Warriors through that run with seven of the team's points.
Fact Box
UNITED SCORING: Paul Faulkner 2-1-5, Brandon Miller 4-2-10, Garret Beech 2-0-4, Sam Henderson 0-0-0, Matt Blake 0-0-0, Andrew Martin 1-1-3, Ben Sell 0-0-0, Jared Powell 1-0-2, Devin Minrod 0-0-0, Caleb Conser 4-0-8, Brandon Davidson 1-3-5. TEAM TOTALS: 15, 9-22, 35.
WEST BRANCH SCORING: Lucas Austin 1-0-2, Beau Taylor 4-3-14, Jerian Thomas 2-0-5, Kolton Kitzmiller 0-0-0, Troy James 5-3-13, Jake Evanoff 0-0-0, Drake Lohnes 2-2-6, Mark Schwingle 1-0-2, Dustin Grenawalt 3-0-6, Kip DeShields 5-3-13, Zack Mucklo 3-0-6, Matt Meiter 4-1-10, Jacob Griffith 4-1-9. TEAM TOTALS: 34, 13-20, 85.
THREE POINTERS: West Branch 5 (Taylor 3, Thomas 1, Meiter 1).
The Warriors led by as many as 19 points in the opening frame, much of that coming off of the fast break.
"We have a lot of depth, and we are going to try to use it," Sellaroli said. "That's why we were going to press so we can maximize that."
Back-to-back 3-pointers by Beau Taylor pushed the Warriors lead to 25 just inside the seven minute mark of the second quarter.
With the Warriors size and speed, they were able to take advantage of the smaller and less experienced Golden Eagles.
"We did a poor job of rebounding," United head coach Matt Mowery said. "We don't have much size. When you don't rebound and you give up second, third, fourth opportunities, you're in a situation where it kills you.".
West Branch took a 43-19 lead into the half.
The second half was more of the same.
West Branch continued to press and it forced the Golden Eagles into numerous turnovers.
"With a young team like that, and constant pressure, we were getting lackadaisical with the ball, and against a team like that you can't do that," Mowery said. "A lot of their points were transition points and easy points. Once we had the ball stopped in the half court it wasn't too bad, but we gave up a lot of lay-ups and a lot of it in transition. We tried to address that in practice but it just didn't go to plan."
Everyone but two West Branch players who dressed scored. Four Warriors finished in double figures including two off the bench.
Beau Taylor led all scorers with 14 points. Troy James and Kip DeShields tallied 13 each and sophomore Matt Meiter scored 10 off the bench.
Brandon Miller led United with 10 points. Paul Faulkner and Braden Davison each added five.
"I was real pleased with how well we played," Sellaroli said. "I saw some things we have to work on, but I like the intensity I thought we played well together pulled for one another and did some nice things."
"We knew it was going to be fast paced," Mowery said. "It was one of those things where we just weren't good handling the basketball. The kids played hard, that's one thing, they didn't give up. But at the same time we're still going through growing pains."
West Branch (1-0) hosts Southeast Tuesday.
United (0-1) plays tonight at Beaver Local.


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The 6 Most Baffling Slang Phrases from Around the World
The world is getting smaller every day; there are now 113 million valid U.S. passports in circulation, more than double the total from 10 years ago. It's become a rite of passage for 18-year-olds to backpack across Europe (code for "drink until my graduation money runs out"). There's every chance that you'll one day travel to one of the countries the phrases below originate from; this article is here to help you decipher the more ... nuanced local phrases.
#6. "Flat Out Like a Lizard Drinking" -- Australia
Jupiterimages/Photos.com/Getty Images
What It Sounds Like It Means:
OK, let's break this down. Lizards don't traditionally drink alcohol, so "a lizard drinking" must have some sort of substance abuse problem. And "flat out" -- that's a reference to the way they lie flat when they're trying to warm up in the sun, maybe? So it's an alcoholic lizard trying to sleep through the day. It must be a euphemism for a really bad hangover! Nailed it. Those lateral-thinking puzzles from third grade are really starting to pay off.
"Tequila Tuesdays ... never again."
What It Actually Means:
Very busy.
Why It Makes Sense:
"Flat out" is Australian slang for "busy," and the lizard isn't actually drinking Jack Daniels in a smoky blues bar, but rather just, you know, water. Lizards move their tongues very quickly when drinking, which is about as busy as a lizard ever gets. It's their main period of physical activity during the day. The phrase could just as easily be "flat out like an unemployed recent college graduate figuring out what ingredients in the house can be used as nacho toppings."
"You can make cheese from mustard and butter, right?"
#5. "How's Your Father?" -- England
Digital Vision/Digital Vision/Getty Images
What It Sounds Like It Means:
How is the man whose sperm provided approximately half your DNA and who wore socks with sandals and taught you all the good swear words? How is that guy? Did he ever finish that book he was writing about the Civil War? Well, great to run into you, give your dad my best. And hey, tell him I said, "That's not my golf club!" He'll know what that means.
Stockbyte/Stockbyte/Getty Images
"I do not know what that means."
What It Actually Means:
Why It Makes Sense:
The phrase "How's your father?" was coined, at least in this context, by British comedian Harry Tate in the 1930s. Playing up the infamous British discomfort with all things sexual, confrontational, or vulgar (or, as they're known in America, the Big Three), he would answer any crass statement with a stammered "I ... er ... well ... how's your father?" The Shakespearean phrase "the beast with two backs" was apparently a little too graphic for fragile English sensibilities, so they snapped up this new, even vaguer euphemism with gusto.
The phrase is pretty old-fashioned now, though, so you might want to rely on more current double entendres, such as "having a bit of the old in-and-out," "parking the Plymouth in the garage," or "doin' it real good."
Digital Vision/Digital Vision/Getty Images
"Ah, you mean 'the old repeating penile thrusts in the vaginal cavity,
leading to seminal ejaculation into the cervix.' Yeah, I know that."
#4. "A Raisin in the Sausage" -- Norway
George Doyle/Stockbyte/Getty Images
What It Sounds Like It Means:
It's a slang term for an STD for sure. Norwegian super-herpes? The Scandinavian Scandal? The ... having raisins on your dick?
George Doyle/Stockbyte/Getty Images
What It Actually Means:
A pleasant surprise in something already good.
Why It Makes Sense:
Norway is consistently rated one of the best places to live on Earth. On the Human Development Index, which ranks countries based on life expectancy, education, and income, Norway has topped the list 10 out of the last 12 years. It's a super-country, where every man looks like Thor and every woman looks like the blonde lady from ABBA, and they all have Ph.D.s.
But do not ever, ever try to convince me that Norway is perfect while they still have a phrase that implies that raisins can improve the quality of anything. Raisins are just grapes that no one loved. Raisins have only ever served as a cruel joke at the expense of chocolate chip cookie lovers and as trick-or-treat giveaways for people who hate children. Anyone who tries to convince you otherwise has just found a convenient way to get around actually using the word "sociopath" when describing themselves.
Photos.com, Stockbyte/Stockbyte/Getty Images
"Two scoops!"


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on November 9, 2012 - 8:06 PM
The Town of Amherst has expanded two new land zoning designations that are meant to refocus developers and property owners on the redevelopment of older parts of town.
Town leaders said the changes should continue to help address the complaints of those who feel they can't make architecturally appropriate or business-friendly property improvements without having to get costly and time-consuming variances from the Zoning Board of Appeals.
"I think it's very responsive to the public," said Supervisor Barry Weinstein.
The Town Board this week voted to expand the "traditional neighborhood business" zoning designation to apply to property along the Kenmore and Bailey avenue corridors. This zoning designation previously has been applied to other parts of Eggertsville, including the Main/Eggert and Harlem/Kensington corridors.
The traditional neighborhood business designation promotes a more pedestrian-friendly, villagelike design. It encourages multistory buildings, pushes more buildings closer to the sidewalk, requires more ground-floor windows and limits and screens parking spaces, said Assistant Planning Director Gary Black.
The traditional neighborhood business designation doesn't change the basic zoning for the older commercial areas, but it does apply new building design standards for everything from signs to landscaping. The new zoning would apply to new or renovated buildings.
The expanded traditional neighborhood business zone approved Monday, called "Eggertsville West" includes the following addresses: 39-71 Kenmore Ave, 3586-3640 Main Street, 3864-4027 Bailey Ave., 225-273 Grover Cleveland Highway, 97 Park Circle and 3 Stevenson Blvd.
The board also applied a new zoning designation called a "live-work district" to property along the Kenmore and Bailey avenue corridors. This area was once entirely residential but was rezoned to a "general business" classification in 1976, Black said. Despite this, most of the properties in this area remained residential.
The live-work zoning designation, first adopted by the town in June, seeks to preserve the homeowner quality of older parts of the town while allowing the properties to house limited commercial uses. It gives residential property owners along major town arteries more opportunities to capitalize on their high-visibility locations while protecting and maintaining the area's residential status, Black said.
Individual properties in the live-work zone could house one or two families, in addition to the following types of low-intensity commercial businesses: ad agencies, tailor and shoe repair shops, art studios, beauty/barber shops, bed and breakfasts, offices, photography studios, on-site arts and crafts production and sale, and day care centers.
Parking and signs would be restricted, and commercial hours of operation would be limited from 8 a.m. to 9 p.m. Most general retail uses would be prohibited. Restaurants, drive-thru businesses and any industrial uses would also be banned.
The Town Board unanimously approved both the expansion of the traditional neighborhood business zone and the newly created live-work zone.
email: firstname.lastname@example.com


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Top Definition
1. A disease caught from a friend who's surname is Fletcher.
2. Fletcher aids.
2. Fletcher aids.
I wouldn't drink that water if I were you, I've got flaids.
We went to Edinburgh and all got flaids.
We went to Edinburgh and all got flaids.
dari Maximator Minggu, 26 Juni 2011
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Flaids- having the flu and aids at the same time.
Kenna has a really bad case of the flaids.
dari Blaskitballr Senin, 24 Februari 2014
The combination of Influenza and Acquired Immune Deficiency Syndrome (AIDS). Essentially as deadly as AIDS but is spread as easily as the Flu.
Damn, Ana just coughed on me, I hope she doesn't give me Flaids!
dari Steven A. Sabtu, 24 Maret 2007
The combination of flannel and plaid. Worn by math geeks only.
This flaid won't do, there's no room for my pocket protector.
dari parental concern Selasa, 05 Juli 2005
An undiscovered, non-proven and childish word for AIDS that is contained within a fly. Full meaning: Fly Aeroimmune Defficiency Syndrome. Thought to have a relation to cooties.
Watch out for that fly! It might have FLAIDS!
dari FLAIDSman Selasa, 23 November 2010


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Fish can't synthesize water. Does that mean they don't need it?
So I've been reading Ray Peat. I know, I know, I lost many of you right there.
But he raises a convincing argument about how unessential essential fatty acids actually are.
I'd like to look at it from a paleo perspective on this thread.
Has evolution failed? If not, how is it that after 10,000,000 years (or so) of human evolution there are essential nutrients, vital for survival and/or reproduction, that the body can't make for itself. Do we just need a 'little more time'?
Yet, the body is quite capable of synthesizing numerous 'non-essential' nutrients from yet other 'non-essential' nutrients. How did that happen?
Perhaps, just perhaps, ol' Ray Peat is right: if a nutrient is truly phsiologically 'essential' the body can synthesize it from other 'non-essential' nutrients and if can't synthesize it, it probably isn't essential after all.
Fish can't synthesize water. Does that mean they don't need it?
Steak, eggs, potatoes - fruits, nuts, berries and forage. Coconut milk and potent herbs and spices. Tea instead of coffee now and teeny amounts of kelp daily. Let's see how this does! Not really had dairy much, and gut seems better for it.
I think the only definition that we really need to agree on to discuss the straw horse proposal above is:
nutrient - any substance that can be metabolized by an animal to give energy and build tissue
Water does not qualify as a nutrient by this definition, nor would oxygen, CO2,...
To prime the pump on this (so far) non-discussion, here's a surprisingly concise article from Ray that summarizes his position on the EFA's:
Membranes, plasma membranes, and surfaces
While most won't want to take the time to hear 'the other side' of the EFA debate, one good reason to read over it is to see just how much biochemistry has to be considered in a fact based analysis. He dives down all the way to question the possibly flawed assumptions regarding cell membranes and pumps.
Some examples:
"Cells can be treated with solvents to remove practically all fats, yet the cells can still show their characteristic membranes: Plasma membrane, mitochondrial membranes, even the myelin figures. The proteins that remain after the extraction of the fats appear to govern the structure of the cell."
"But sometimes experiments seem to be designed as advertising, rather than science. Recent studies of the effects of fish oils on night vision or development of the retina, for example, seem to forget that fish oil contains vitamin A, and that vitamin A has the effects that are being ascribed to the unsaturated fatty acids."
i will say that it can help to clear up the definition of "essential" in nutrition. it just means that your body can't make it. we cannot endogenously produce linoleic acid or alpha linolenic acid. how much we need is an entirely different story. you will get small amounts of both on almost any diet - it's nearly impossible to consume no PUFAs.
Things that our body can't produce are usually of that sort BECAUSE we have evolved to procure them elsewhere. Vitamin C also comes to mind in this vein....Vitamin D from the sun.....so there is/goes that argument.
Peat dives into a lot of stuff. Most of it is very old studies and those performed on mice (like 90% of references are over 40 years old!). We are not mice, and anybody can cherrypick to make a good case. Doesn't mean I would dismiss his views only on that, but take into account the EFA content of almost every animal we come across that is edible. Do you think wild animals have been blighted somehow?
I have no problem with biochemistry IN CONTEXT. Which is to say you can't take what we know and try to hack the human system without taking our traditional growth and evolution into account. We simply don't know enough to work it without that angle.
What you may be able to take away is that there is no need to go out of your way to get extra O3 from a fish oil as long as you are also avoiding the extra O6 from seed oils and other refined junk. In the end Primal does limit PUFA to an acceptable level. If you are trying to get to near zero PUFA as a body hack....good luck. Its not something that occurs in traditional society or in our evolutionary history .....least far as I know.
Last edited by Neckhammer; 07-26-2012 at 06:48 PM.
"Sodium is a mineral, an essential nutrient. It helps to maintain blood volume, regulate the balance of water in the cells, and keep nerves functioning. The kidneys control sodium balance by increasing or decreasing sodium in the urine"
Yep, necessary for you to live.
And any other of a rather large number of vitamins, minerals, and amino acids...
Vitamin C? You can't synthesize it, but you definitely need it. *See scurvy. Arrrgh Matey!
Choline? You can't synthesize it... "common signs of choline deficiencies are fatty liver and hemorrhagic kidney necrosis... Choline low diets can also cause infertility, growth impairment, bone abnormalities, and hypertension. Choline deficiency is considered to both initiate and promote cancer activities."
Thiamine? You can't synthesize it... "Thiamine deficiency commonly presents subacutely and can lead to metabolic coma and death."
And on and on and on...
That said... Essential Fatty Acids...
You are probably getting plenty by eating primal foods.
If you want more ALA, the "hard" one to get...
Walnut oil makes a fabulous vinaigrette.
I actually really like Chia seeds. *shrug*
Eat some fruit... those kiwi seeds have ALA!
I also eat purslane (aka that decorative Portulaca plant they sell at the garden center) in my salads, it's a little flowering plant, it's cute, fleshy succulent leaves, tasty too. And has ALA.
I also grow and eat Shiso (aka Perilla)... I had no idea it was a good source of ALA until today. Awesome.
This shit is not hard to get at all.
You have your way. I have my way. As for the right way, the correct way, and the only way, it does not exist.
~Friedrich Nietzsche
And that's why I'm here eating HFLC Primal/Paleo.
Purslane & shiso are nice. Korean grocers have big ol shiso leaves in stacks for sale, they are lil powerhouses of nutrition...
"Science is not belief but the will to find out." ~ Anonymous
"Culture of the mind must be subservient to the heart." ~ Gandhi
"The flogging will continue until morale improves." ~ Unknown
@ jakey,
Yeah, that really is the definition of 'essential'. But then that's one of Ray's points, it's being used to market supplements in a dishonest way. No surprise there.
@ neckhammer,
@ cori93437
Good points, but I feel the need for...splitting some hairs. The way I see it there are 2 kinds of biologically 'essential' nutrients: those that can by synthesized and those that can't. But by 'can't' I don't mean 'aren't', I mean not physically possible. Those would include things like sodium, oxygen and water (as suggested by Knifegill). They can't be synthesized because they're elements, or simple combinations of them. The only way elements can be synthesized is through nuclear reactions, which still require yet other elements. So, 'synthesis' generally refers to chemical reactions that transform one type of organic molecule into another in the body.
Example: carbohydrates can be converted to fat. Thus, we say the body can 'synthesize' fat (from carbohydrate).
But it is interesting that the body can't synthesize Vitamin C (an organic molecule). It can be synthesized by primates and a location in the human genome has been identified where the protein for Vit C synthesis used to exist.
So, I ask again, but this time with respect to Vitamin C, did evolution fail us?
(1) I am 100% on-board with the primal exercise blue print. It reduces the problem of exercise down to its simplest form and provides a solution that can be used for a lifetime.
(2) I'm not on-board with the primal diet blue print. In fact, I'm not on-board with any diet plan but a man can hope to find the right answer before it's too late.
Vitamin C is readily available from plants and animals. There is no need for humans to synthesise it while plants and animals oblige
Four years Primal with influences from Jaminet & Shanahan and a focus on being anti-inflammatory. Using Primal to treat CVD and prevent stents from blocking free of drugs.
Eat creatures nose-to-tail (animal, fowl, fish, crustacea, molluscs), a large variety of vegetables (raw, cooked and fermented, including safe starches), dairy (cheese & yoghurt), occasional fruit, cocoa, turmeric & red wine


text:
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Top Definition
Whenever you are piss-pound drunk and you are aware of how fucked up you are but yet you have a sense of self satisfaction and accomplishment an feel nothing short of phenomenal. Your sloppy but you feel super.
John: Fred, you look pretty hammered buddy? You doing OK?
Fred: Fuck man, I'm sluper!
Fred: Fuck man, I'm sluper!
Boogida tərəfindən 20 Avqust 2011
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text:
Thursday, March 21, 2013
The Palmetto Park/Robynwyn Civic Association is hosting a Stop the Violence rally in Wassamassaw Park Saturday.
The event, which will feature several guest speakers and area gospel choirs is one of a number of ongoing initiatives aimed at combatting violent crime in Summerville, particularly in the Robynwyn and Palmetto Park neighborhoods, said association president Louis Smith.
The association was formed in direct reaction to the murder of 35-year-old John Hancock, who was shot to death in his own driveway in the Robynwyn neighborhood in October of 2012, Smith said. Thus, one of the prime directives of the organization is to get active -- and very serious – about reducing violent crime in this area.
The group will also launch a petition to call for a referendum in the town to enact gun control ordinances, Smith said.
"We want to ban assault rifles and similar weapons and we believe the town should take such a stand," Smith said.
In addition to Saturday's rally, the association has planned and is in the process of implementing several major community outreach programs, Smith said.
Some of these initiative include working with the Summerville Police Department to establish a gun buy-back program, setting up tutoring and mentoring programs for youth, and establishing a chaplain program for victims of violent crime, Smith said.
Finally, the association understands that the community must be actively involved in crime prevention to make the crime rate go down and is encouraging citizens to step up and get involved, Smith said.
However, an important aspect getting citizens involved is keeping citizens informed, Smith noted. To that end, the association has been working to sign people up for the free text message service NIXLE, which instantly communicates real time updates from the police department via text message. It also provides a way for the community to inform the police of any criminal or suspicious activity, he said.
Another issue the association is interested in exploring is bringing public transportation services out to some of these neighborhoods, Smith said.
The Stop the Violence rally starts at 7 p.m. in Wassamassaw Park, off Hwy 78 in Summerville. The public is invited.
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text:
[nggallery id=87]
Oh, was I supposed to know Claire from Snow Day was Sloan from Entourage? If so, I didn't. So I apologize.
Anything can happen on a Snow Day!
A+ Gif
she will always be sloan to me. Hey E tell sloan i said whats up.
Thanks Nate!
I never realized she was that girl from Snow Day. I fucking loved Clare
I have always wanted to do really dirty things to her, beginning with eating her ass with a spoon
23 playing a HS girl…dont have to feel guilty at all BONERS
half chub at work, NBD
check out "women in trouble" and "elektra luxx", she plays a hooker. you're welcome
to be clear, she (sadly) doesn't get nude in those, but some great skimpy outfits
If I pulled down those sweats and saw skidmarks, it wouldn't delay the warp speed with which my face buried itself in those Canadian jew buns.
i love sloan so much
It's also her Birthday, you putz.
So hot, and so confusing. Sometimes her tits look huge, and amazing. Other times they look fine. Either way she's a smoke, but I need to see those tits bare… for research.
No.1 for me.
would trade an organ to get up in that
sloan from entourage not fucking snow day
I've got my FIRST check total of $1643 for one week, nicest cool. working from home saves money in several ways.I love that. I've recently started taking the steps to build my freelance Job career so that I can work from home. here is i started,… http://goo.gl/j869zd
She was in an episode of 'Are You Afraid Of The Dark'. I'd fingerbang her even back then.
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See images from Himawari-8 in the new satellite viewer
This demonstration product is most suitable for people
with fast internet connection and high data allowance.
Low-definition satellite images
Satellite View Selection
01:00 ACST on Wednesday 28 September 2016 | Cloud/surface composite, Australia
Images from Japan Meteorological Agency satellite Himawari 8 via Bureau of Meteorology.
IDY28000 Australian Government Bureau of Meteorology Bureau National Operations Centre Satellite Notes for the 0000UTC Chart on 28 September 2016 Issued at 11:29 am EST Wednesday on 28 September 2016 A strong cold front and rapidly intensifying low pressure system are crossing the Bight generating a large cloud band with embedded thunderstorm activity. A field of convective cellular cloud can be seen in the cold air behind the front. An upper level cloud band is streaming down from tropical convection over Indonesia to central Australia. This cloud is brought along by the upper level subtropical jet stream. Patches of low cloud can been seen over southwest and southern coasts of Western Australia due to an onshore southerly wind flow.


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Step 2
My Own Laundry™
- Color:
- multi
Qty: 1
- 1
- 2
Description: Portable play sets that go anywhere! Electronic washing sounds, lights and clicking knobs create a realistic experience!
- Pretend you're doing the laundry in this portable washer right alongside mom & dad
- For easy clean up, store all accessories inside
- Includes spray bottle, clicking iron, and hangers
- 2 "AA" batteries (included)
- Minimal adult assembly required
- Recommended for ages 2 and up
Material: Plastic
Brand: Step 2
Origin: Imported


text:
Top Definition
Jean shorts. Worn mostly by children and douchebags. Jorts are perhaps the easiest way to recognize people you will not like. If you wear jorts, you probably don't talk to girls. The term "jorts" does not apply to jean shorts worn by black people, as those are entirely acceptable.
The kid next to me was definitely a total dick; he was wearing jorts.
Beküldő: theSuperJesus 2005. augusztus 31.
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a combination of the words "jean" and "shorts" used to describe the hideous attire, usually sported by NASCAR afficianados and men over 40. Sometimes Jorts are accessorized with a lovely cellphone belt clip and a braided leather belt, but not always. Sometimes the Jorts wearer lets the Jorts speak for themselves.
While at a baseball game, I noticed a plethora of adult males with no shirts on, drinking copious amounts of beer while proudly wearing Jorts.
Beküldő: Kelly 2006. június 15.
F*ck you, I can dress any way I want.
If you talk about somebody's momma it tends to get sloughed off; if you talk about somebody wearing jorts, you better be ready to fight.
Beküldő: Forced Earphones 2009. július 4.
jean shorts; stylish casualwear for the unpretentious
Dude, those jorts are slammin'! Did you get them at Penney's?
Beküldő: Big Moop 2008. szeptember 14.
jean shorts, such as those worn by male Florida Gator fans at the Georgia-Florida football game.
"Don't talk to him; he's obviously a Florida fan with those jorts he's wearing."
Beküldő: godawgs 2006. március 23.
short for "jean shorts"
Look at the redneck in the jorts. Man, that guy is one bottle of moonshine short of marrying his sister.
Beküldő: ColumbusBuck 2007. október 29.
Jorts are a short word for Jean Shorts
Dude, why are you wearing jorts? You look like a douche.
Beküldő: Quincy Morris 2008. március 14.


text:
Really cool. Down to earth guy. Known for his sweet smile and how much of a gentalman he can be. Drop dead sexy. He will help anyone in need of it. Sweet, funny, with a great personallity. Knows how to make his bestfriends smile when they need it. Gives great hugs. He thinks he is soo funny but not really.
"Did you see that girl crying in the hall?"
"Yeah, I also saw Cody helping her."
"Yeah, I also saw Cody helping her."
作者 babycakes178 2010年2月07日
A term derivative from the drug, codeine, often used while under the influence of alcohol/drugs instead of finishing the word, they just mutter "cody"
dude pop another cody
作者 John Baker 2006年6月07日
A great guy that is a friend to all. He has many of friends but tends to stick to those he's closest to. some what of an athletic build, tends to enjoy working out and sports, but never can find himself as good looking or attractive. usually around a medium height with blue eyes and light brown hair. usually falls for girls with blonde hair, green eyes, around his height with great personalities.
Today i saw this guy and he looked just like a Cody!
作者 dj pauly c 2010年2月06日
1. Excessive masturbation usually in the janitor's closet at school.
Dude, I think that guy was just pulling a Cody.
作者 nila_twisted.image 2008年4月25日
An amazingly smart man who succeeds at everything he puts his mind to. He is sweet, caring and always knows exactly what to say to brighten any day. He is a perfect boyfriend, and an amazing lover.
Me: I have the most amazing boyfriend
Friend: Oh yeah?
Me: Yeah, Cody
Friend: Oh yeah?
Me: Yeah, Cody
作者 handcamplove 2010年11月22日
the nicest guy you'll ever meet, very caring, sweet and you have alot in common. Makes you smile tell it hurts
that guy is a cody
作者 sfgjsfgmsfhm 2010年12月12日
The hottest guy you will ever meet.
Has an amazing talent for pleasuring a girl.
He has big beautiful brown eyes that you just get lost in
Has an amazing talent for pleasuring a girl.
He has big beautiful brown eyes that you just get lost in
You'll never forget a night with Cody
作者 Laughuntilyoucry 2011年10月16日


text:
Top Definition
a beautiful yet lost girl who is still trynna find her self in life. she's very generous. she love to give. she falls in love with this one guy she just cant leave alone because she care so much about him even though he treat her like dirt. eventually one day she will leaave him. she have one out-standing friend who's been there for his since forever. if you have a friend named Ralisha you should keep her.
Penny: Have you seen Amber today?
Ron: Yeah she's down at the shelter, she's such a Ralisha.
Ron: Yeah she's down at the shelter, she's such a Ralisha.
av Lovedbyerbody 16 april 2011
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Remotely created checks have become hugely popular what with the convenience they bring with them. They have become useful payment devices for customers and vendors alike, but the downside to a remotely created check is that it is highly vulnerable to fraud.
Before we go into how swindlers manipulate remotely created checks, we'll briefly explain what a remotely created check is. A remotely created check is just like any other check. The only difference is that there is no signature of the account holder authorizing the check. In place of the account holder's signature will be a statement that says the customer has authorized the check or bears the customer's name in print.
You may have already noticed why remotely created checks are prone to manipulation. Since they require mere statements and printed names to confirm authenticity, and not the more reliable and more difficult to fake signatures they can be easily be used to perform transactions.
And what is even more frightening is that almost anyone can create an unauthorized remotely created check. All that is required is the bank's routing number, the individual or company's account number to be debited and a statement. Amassing money for fraud through remotely created checks is a piece of cake as it does not require the account holder's signature.
One particularly egregious example of using remotely created checks to create fraud is outlined in the FTC's news release of a 10 million dollar remotely created check scam which worked as follows:
In papers filed with the court, the FTC charged that since January 2004, defendants using the name "Pharmacycards.com" electronically debited thousands of consumers' accounts for $139, without consumers' knowledge or consent. Prior to the unauthorized debiting of their checking accounts, consumers had no contact with the defendants. According to the FTC, the defendants attempted to debit more than $10 million from consumers' checking accounts in less than three months. The FTC alleges that the defendants gained access to the banking system via third-party payment processors by claiming that they were engaged in a legitimate business – selling pharmacy discount cards. Their Web site touted the benefits of their cards and advertised retailers such as Target and Wal-Mart that participated in the discount program. The Web site also listed a toll-free customer service number and a mailing address in Canada. According to the FTC, the major retailers' logos were hijacked – they didn't participate in the program. The mailing address was false and mail sent to the address was returned.
Some consumers received letters after money had been withdrawn from their account explaining the program and saying that because the consumer had previously purchased a product from one of the defendants' "marketing partners" using their checking account, the consumer did not need to provide the account number again. The letter said that consumers who were not interested could call the toll-free customer service number to cancel within five days of receiving the letter. By this time, the money already had been debited from their accounts.
According to the complaint, the defendants provided consumers' checking account numbers to the third-party payment processors with whom they had contracts. One processor alone debited more than 72,000 checking accounts for the defendants, generating more than $10 million in attempted debits. While more than 50,000 of those transactions were cancelled or returned, many other consumers were unaware of the transaction or unable to have it reversed, and $139 was removed from their accounts without their authorization.
You can read the news release FTC Halts Unauthorized Bank Charges In Bogus Pharmacy Card Scam here.
What makes remotely created checks even more dangerous financially is that remotely created checks are paper checks that are extremely hard to monitor. It is easy for a few remotely created checks to be masked by thousands of checks with signatures thus making it impossible to detect a remotely created check used to commit fraud. On top of that, remotely created checks cannot even be identified in the first place.
So while the use of remotely created checks might have made payment of bills much more convenient but the disadvantages of remotely created checks outweigh its advantages. Thus it would be much wiser of you to resort to other, more advanced and safe options.


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Music competition to be held Jan. 19
SHEPHERDSTOWN - Shepherd University's Department of Music will host its annual vocal competition on Jan. 19 in the Frank Center. The competition is open to high school juniors and seniors. The application deadline for the competition is Dec. 28.
The daylong event will consist of preliminary auditions, a selection of finalists, an honors recital presented by Shepherd students, and an awards ceremony including performances by the chosen prize winners. The honors recital and awards ceremony are free and open to the public.
The competition offers a $1,000 for first place, as well as other cash prizes for second and third places, which will include the $300 Jane Grissinger Memorial Award prize from Shepherd musician and faculty member Anne Munro.
The vocal competition is an annual event organized by the voice department at Shepherd in an effort to provide young singers the opportunity to perform and receive feedback from professional musicians. This is an opportunity for young artists to become familiar with Shepherd's music program and what it has to offer.
Former winners of the competition have performed with the New York City Opera, starred on Broadway and in national touring companies, and won awards including the Marian Anderson Prize and the Rosa Ponselle Young Singers Prize.
For more information on the competition, contact Dr. Robert Tudor, director of vocal studies and chair of the department of music at Shepherd, at firstname.lastname@example.com or 304-876-5237.
LPN and Surgical Tech training set
HEDGESVILLE - The Jill S. Weekley Learning Center at James Rumsey Technical Institute will offer an LPN and Surgical Tech Preparation program for anyone wishing to enter the 2013-2014 LPN or Surgical Tech programs. Attend an orientation and get all the specifics for LPN/Surgical Tech preparation classes that will be available starting in January.
Orientation dates:
- Wednesday, 9 to 10:30 a.m.
- Thursday, 6 to 7:30 p.m.; and
The prep course will offer basic skill assessment, which will help to determine the need for review in the areas of reading/vocabulary skills, general math skills and general science knowledge. The Jill S. Weekley Learning Center also has several computer aided self-study programs which are designed to offer additional practice in areas to be assessed on the LPN/Surgical Tech pre-admission exam.
For additional information, call the Jill S. Weekley Learning Center at 304-754-9712.
Student video contest offers $1K top prizes
MARTINSBURG - A national grassroots group is offering high school students the chance to win $1,000 and other cash prizes in a student video PSA contest.
Population Connection, the nation's largest grassroots population organization, is again hosting its "World of 7 Billion" contest. Students in grades 9-12 are asked to create a 30-45 second public service announcement that illustrates the connection between world population at seven billion and one of the following topics: Food security, wildlife habitat, or the global status of women and girls.
Cash prizes will be awarded to four winners in each topic area. Three grand prize winners will receive $1,000. Participating teachers will receive free curriculum. The deadline for video submission is Feb. 21, 2013.
For full contest rules or to see previous winning videos, please visit www.worldof7billion.org.


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I know there has been a big team working hard behind the scenes at I-COM to ensure that the new site is as good as it can be. As I don't know all of the people involved, I would ask you to pass on our great thanks and sincere appreciation for all their efforts.
A striking new website built on the award-winning Magento platform. A new design that improved customer conversion rates. A potent mix of Social Media and SEO that raised brand awareness and increased levels of targeted traffic to the website.
Our work with IL2L is a fantastic example of how an integrated marketing strategy can transform an online business; an example of Web Design and Development, SEO and Social Media working together in perfect harmony to produce excellent results.
We worked closely with IL2L for the duration of the project, agreeing key objectives and outcomes from the outset. Regular client review meetings kept the project on track, ensuring we delivered on time and within budget, whilst invaluable input from I-COM's multi-disciplined team gave the new site its desired impact.
Overall, a very successful project, and a great example of agency and client working very closely together to deliver something truly special.
Our paid search team's work produced a 43% increase in year on year revenue from paid search traffic whilst maintaining the same PPC budget, and ensured that the number of sales made on the site drastically increased.
Manchester based IL2L.com (I Love 2 Love) is an online fashion boutique which stocks two of its own leather jacket brands, IL2L and Barneys, alongside collections of clothing and accessories from household names like Levi's, and smaller labels like House of the Gods. They carry an extensive range of leather jackets, accessories, footwear, bags and gifts from designer brands such as Kipling, Fossil, Fiorelli, Eastpak, Paul Frank, New Era, Pineapple, and Ted Baker.


text:
Protean 3D is Lasergene's application for exploring macromolecular structure, motion, and function. Rich, synchronized graphical views allow you to see the 3D molecular structure, the annotated sequence, and the analysis of applied prediction methods simultaneously, enabling easy identification and analysis of secondary structure elements. Protean 3D also provides access to the Motion Library, where you can browse and search over 300 animated and annotated macromolecular conformational changes, and to NovaFold, which allows you to predict three-dimensional structures for protein sequences.
- Import protein structure or sequence files, or download PDB files directly from the Protein Data Bank. Or import multi-model PDB files to view conformational changes.
- View and analyze protein structure predictions from NovaFold.
- Open multiple structures in the same document to view split entry structures or align similar structures.
- Browse and search over 300 animated and annotated macromolecular conformational changes calculated by the Yale Morph Server.
- Starting with a structure or protein sequence file, evaluate a broad selection of secondary structural characteristics such as amphiphilicity, charge density, disorder, flexibility, hydropathy, and more, by applying prediction methods.
- Easily identify residues, binding sites, disulfide bonds, helices, and sheets using annotations in the Sequence View.
- Predict B-cell epitopes based on protein sequence data.
- Use the SUMOylation method to predict protein stability.


text:
Cicchino continues to overcome odds
Eagle wrestler feels fortunate to be on mat
December 1, 2012
HEDGESVILLE — The pain was unmistakable, but the heartbreak was even more devastating. Hedgesville wrestler Michael Cicchino writhed on the mat in pain, his elbow completely blown out....
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For Sale:
I am selling my one person Red Wings ping pong table. This is a unique collectible and I priced it to sell. Smoke and pet free home. Dimensions are approx 12 inches long, 9 1/4 inches wide, handle is 4 1/2 inches long, net stands 1 1/2 inches tall. Ping pong balls not included.
I would like $10 for the item and $5 for shipping. I accept paypal or money orders.
Contact me via PM.
For Sale: Red Wings One Person Ping Pong Table $10 See Pics
Started by stevehayboer, Feb 23 2012 11:56 PM
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Top Definition
Sticking two fingers in the vagina and one in the anus.
Also known as the Shocker
Also known as the Shocker
Dude, I gave her the shocker and she actually liked it!!!
Beküldő: t0xicity 2003. december 21.
Trending Now
Can you define these popular missing words?
Manual hand stimulation of the female genitals and anal area whereas two fingers are inserted into the vagina (pink) and one in the anus (stink).
Sara likes two in the pink and one in the stink before sex.
Beküldő: Maxwell 2003. december 19.


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In day two of the trial between Britney's former confidante Sam Lutfi and her family, Jamie Spears's attorney Leon Gladstone portrayed Britney's parents as humble, working-class folks from Kentwood, La., who supported her Mouseketeer beginnings, grew overwhelmed by their daughter's superstardom and who ultimately took extreme measures to save her life.
Lutfi, 38, is suing Britney, 30, for allegedly not paying him 15 percent of her earnings as her purported manager; Jamie Spears for alleged battery; and Lynne Spears for defaming him in her 2008 book, Through the Storm.
Gladstone said Britney's parents saw her as "a ray of light, humble and nice," but that began to change after her painful breakup with Justin Timberlake in 2002, leaving their daughter "depressed and angry" in her early 20s.
Things went from bad to worse, Gladstone said, citing Britney's annulled 55-hour marriage to childhood friend Jason Alexander, which he called the "beginning of behavior that became increasingly bizarre," and her marriage to Kevin Federline in Oct. 2004, which he said was another "impulsive decision."
Following Britney's infamous head-shaving incident in Feb. 2007, Jamie confronted his daughter, Gladstone said, telling her, "You're going to kill yourself or one of your kids," and put her in rehab.
'Leave Our Family Alone'In Sept. 2007, Jamie allegedly began receiving bizarre phone calls from Lutfi, who first identified himself "as an agent of the government" who was there to help Britney, Gladstone said. Jamie allegedly asked Lutfi repeatedly to "leave our family alone; let us take care of our daughter."
Jamie also received a message from someone warning that, "Sam will probably make [Britney] commit suicide," Gladstone said. Reading the message to jurors, Gladstone continued: "I personally know Sam Lutfi, and he's a master manipulator. He almost made my good friend ... commit suicide."
Gladstone also told jurors of Lutfi's checkered past: That the L.A. native had been previously slapped with restraining orders from a neighbor as well as a roommate in 2004 and '07, respectively, as well as being sued for fraud and harassment.
Lynne & Jamie InterveneOn Jan. 28, 2008, after Britney was first hospitalized at Cedars-Sinai Medical Center, Jamie and Lynne confronted Lutfi at Britney's Beverly Hills home.
"In full control of himself," Gladstone says, "Jamie says, 'Leave my daughter alone, get out of our lives,' and touched him one time," denying to jurors that it was a punch.
Stephen Rohde, an attorney for Lynne, read from her Feb. 2008 sworn declaration in which she described the events at Britney's home that night.
"Sam told [Lynne's friend] Jackie and me that he grinds up Britney's pills, which were on the counter and included Risperdal and Seroquel," Rohde read.
"He told us that he puts them in her food and that was the reason she had been quiet for the last three days. "
Lutfi also demanded that Lynne do what he ordered, according to her statement. "I'm the one who spends 24/7 with your daughter," Lutfi allegedly said. "I sleep in cars outside her house so she can't leave."
Lynne also stated in her declaration that Lutfi "told me that if he weren't in the house to give Britney her medicine, she would kill herself. Then he said to me, 'If you try to get rid of me, she'll be dead and I'll piss on her grave.'"
Three days later, Britney was forcibly hospitalized a second time at UCLA Medical Center, and Jamie's legal control over his daughter was approved by a judge the following day.
No Legit ContractJoel Boxer, an attorney representing Britney, also argued Friday that Lutfi was never legitimately hired as the singer's manager, that there was neither a written or oral agreement between then, and that his control was "a product of undue influence" over her.
Lutfi "used her vulnerability to gain her trust and friendship, and he abused it," Boxer told jurors.
Boxer added that while Lutfi was in Britney's life, he created no new business deals for her and that any cash she generated during that time was due to contracts negotiated before Lutfi came on the scene.
An attorney for Lynne concluded the day's opening statements by saying there was no way Lutfi was defamed by her book "because his reputation was at such a low point [in the tabloids] that nothing could reduce it further."
Witnesses are expected to be called to the stand when the trial resumes Monday.


text:
on June 14, 2013 - 7:41 AM
A Buffalo woman faces a maximum of four years in prison following her third conviction for drunken driving, Erie County District Attorney Frank A. Sedita III reported Wednesday.
Tammy Karek, 32, of Eden Street, pleaded guilty to felony DWI and leaving the scene of an accident before State Supreme Court Justice M. William Boller. He set sentencing for Dec. 6.
Sedita said Karek admitted to hitting a vehicle turning into a driveway Jan. 28 on Potters Road in West Seneca and then trying to flee. After she was stopped by West Seneca police, a breath test recorded her blood alcohol content at 0.15 percent, nearly twice the legal limit.
Sedita noted that Karek previously was convicted of driving while impaired and misdemeanor DWI.


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Kid Motorz
12V Hummer H2 Ride-On
- Color:
- pink
Qty: 1
- 1
- 2
This item is final sale and non-returnable.
Estimated Delivery:
Description: Bring the toughest vehicle home to your little one. Designed for speeds of up to 5 mph, the Kidz Motorz 12V Hummer H2 Two-Seater Ride On has it all. Inside, there are two forward and one reverse gear controls and pretend seat belts. The chrome front grille and hubcaps allow this Hummer to ride smoothly over paved surfaces. There is even a storage space in the trunk for all your tot's toys, supplies and driving necessities. Get movin' in style with the Hummer H2!
- Battery operated Hummer ride-on
- Rolls smoothly over paved surfaces
- 2 forward and 1 reverse speed
- Seats up to 2 children
- Maximum speed: 5.0 miles per hour
- Maximum weight capacity: 130 pounds
- Storage area at the back with pretend seat belts
- Chrome hubcaps, grille and headlights
- 12 volts rechargeable battery and a UL-listed charger included
- Easy assembly required
- Measures 33"L x 40½"W x 26"H
- Age: 3 and up
Material: Metal, Plastic, Steel
Care: Spot clean
Brand: Kid Motorz
Origin: Imported


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Property taxes a nightmare
May 20, 2012
My whole life, up to now, has been spent in New York. I was born in New York, raised in New York. I went to college in New York, was married in New York. The list could go on for pages. Until now....
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Wall Street Decline Takes Its Toll...
Quadruple Helices Appear To Have Role...
Adapting to Evolving Business Environments Is...
As Immunotherapy Revolutionizes the Cancer Treatment...
Firms will collaborate on identifying biomarkers of response to SuppreMol's lead candidate SM101.[© Yuri Arcurs - Fotolia.com]
SuppreMol is teaming up with Protagen to identify biomarkers of response to SuppreMol's clinical-stage systemic lupus erythematosus (SLE) candidate SM101. The firms' collaboration will exploit Protagen's UNIarray™ platform to identify serum autoantibody signatures that indicate which patients enrolled in SuppreMol's Phase IIa SM101 study are most likely to benefit from treatment.
SuppreMol says the work may in addition allow the classification of patients into subgroups of SLE. The collaboration and the Phase IIa trial are being supported by the German Federal Ministry for Education and Research (BMBF).
The production of autoantibodies reflects the immune response to chronic autoimmune diseases such as SLE and rheumatoid arthritis as well as neurodegenerative diseases and cancer, Protagen explains. The firm's UNIarray platform has been designed to identify such autoantibody signatures in blood for the development of in vitro diagnostics and companion diagnostics for patient stratification and therapy selection.
It claims identifying serum or plasma autoantibody signatures has a number of advantages over genomic signature-based approaches. The autoantibody technology allows the multiplexed assessment of thousands of proteins, requires little sample, and can be used with archived samples. In addition, the IgG analyte is highly stable in patient samples, present at high levels, and binds to target antigens with high specificity and affinity, negating the need for enrichment steps or elaborated sample preparation, Protagen claims.
Protagen is exploiting the UNIarray platform both in house and through diagnostics and biomarker discovery and validation collaborations. In April the firm inked a collaboration with Biogen Idec focused on the discovery of treatment response biomarkers in relapsing-remitting multiple sclerosis.
SuppreMol is developing soluble Fc gamma receptors (sFcgRs) for the treatment of autoimmune diseases including primary immune thrombocytopenia (ITP), SLE, and rheumatoid arthritis. Lead candidate SM101 is a recombinant, soluble, nonglycosylated version of the human Fcγ receptor FcγRIIb, which is designed to bind autoantibody/autoantigen complexes and block the triggering of Fcγ receptors on the surface of immune cells.
A Phase Ib/IIa multicenter trial evaluating SM101 in the treatment of ITP was initiated during early 2010. The Phase IIa placebo-control study in SME was initiated just last month and will enroll 50 SLE patients with or without a history of lupus nephritis.
SuppreMol is in addition developing a mAb targeting FcγRIIb, for the treatment of subtypes of autoimmune diseases that cannot be treated with SM101. The firm says the antibody does not interfere with the IgG-binding of the Fcγ receptor and therefore acts as a nonblocking antibody that still allows the receptor to bind to immune complexes and send inhibitory signals that amplify a negative regulating effect on the autoantibody production. Additional preclinical research is focused on the development of sFcRs for the treatment of SLE and rheumatoid arthritis.
In May SuppreMol licensed an IL-3 antibody developed by the molecular immunology research group at the University of Regensburg. The firm says an antibody-based IL-3 inhibitor may provide a new approach to treating rheumatoid arthritis, either during the early stages of the disease or during flares or exacerbations.
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