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David Goldman/Associated Press
A cancer diagnosis often inspires people to exercise and eat healthier. Now, the experts say there�s strong evidence that both habits may help prevent the disease from coming back.
New guidelines issued Thursday by the American Cancer Society urge doctors to talk to their cancer patients about eating right, exercising and slimming down if they�re too heavy.
That�s not something most doctors do, said Dr. Omer Kucuk, an Emory University oncologist who has researched the effect of nutrition on prostate cancer. They�re focused on surgery, chemotherapy or other treatments for their patients, he added.
�Usually, the last thing on their mind is to talk about diet and exercise,� Kucuk said.
Cancer-society officials have long encouraged healthy eating and exercise as a way to prevent certain cancers. They, and others, have tried to spread that gospel to cancer survivors as well. Indeed, the cancer society has a certification program for fitness professionals who work with cancer survivors.
But until now, the group didn�t think there was enough research to support a strong statement for cancer survivors.
Hastine Reese, a breast-cancer survivor, says she began to exercise because her husband � not her doctor � pushed her. Besides being good for her health, he thought it might help pull her out of the depression that came after her diagnosis and double-mastectomy.
�When you�re first diagnosed with cancer, you go into a dark place,� Reese said as she finished a one-hour exercise class last week at DeKalb Medical Center in Decatur, Ga.
Exercise has changed that. �I�m coming into the light, and it�s getting brighter and brighter,� she said.
Being overweight or obese has long been tied to an increased risk of several types of cancer, including cancers of the colon, esophagus, kidney, pancreas and � in postmenopausal women � breast. But there hadn�t been much evidence about the effects of diet and exercise for people who had cancer.
The last five years saw more than 100 studies involving cancer survivors, many of them showing that exercise and/or a healthy diet was associated with lower cancer recurrence rates and longer survival.
Most of the research was about breast, prostate and colorectal cancers. The evidence is more meager when it comes to other cancers, including the deadliest kind, lung cancer. Also, most of the work involved observational studies, which can�t prove a cause and effect. Still, the volume of research was compelling.
�We�ve got enough data now to make these recommendations,� said Colleen Doyle, the organization�s director of nutrition and physical activity.
At least two other medical groups have strongly recommended exercise and healthier eating for cancer survivors, but the cancer society�s new guidelines are expected to have much greater impact. It�s the nation�s largest cancer charity in both donations and the number of volunteers, and it funds more cancer research than any other nongovernmental agency.
There was a time when cancer patients were thought of as gaunt and dying souls. Many cancers were diagnosed at a late stage, after the disease had ravaged the body and caused weight loss.
But better screening and treatment has made early diagnosis of cancer more common and survival more likely. Today, more than two-thirds of cancer patients live at least five years. The ranks of cancer survivors have grown, with more than 12 million Americans identified as cancer survivors.
Meanwhile, obesity has boomed. More than two-thirds of U.S. adults are now considered overweight or obese.
The guidelines recognize that for some people just eating enough food is a priority, and diet advice can vary during treatment. The cancer society also notes that some people may be too weak at times for vigorous exercise. But experts say that even modest activities, such as lifting soup cans while watching TV, can help.
Women seem to take to exercise and diet recommendations more readily than men, or to push their spouses to follow the advice, some doctors said. Most of Reese�s classmates were women.
�I find women to be very, very proactive,� said Dr. Allen Lawhead, a gynecologic oncologist at DeKalb Medical Center. �Men, we traditionally go back into our man cave and hide.�
Lawrence Genter, a survivor of non-Hodgkin�s lymphoma, was one of three men in Reese�s class of about a dozen. �I�m here because of my wife,� he said.
For another cancer survivor, exercise came easy but eating healthy was a challenge. During chemotherapy, nausea is common and food can seem unappetizing.
�The key thing is to eat period � whatever you can get down and keep down,� said Bob Falkenberg of Alpharetta, Ga., who was a marathoner and long-distance cyclist before he was diagnosed with leukemia.
What did he eat during chemo? Mexican food. Hamburgers.
�I had people bring in pizza at one point,� he laughed.


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Holland-free zone here. Tell the world what you'd do this off-season. Leave your predictions of what Holland's going to do elsewhere.
Here's what I'd do:
-Buy-out: Compliance: Quincey (save $3.8M) and Samuelsson (save $3M). Ordinary: Colaiacovo (save $1.9M), Bertuzzi (save $1.5M), Tootoo (save $1.3M), Gustavsson (save $1M) and Eaves (save $0.8M).
-Recall: Tatar, Mrazek and *one-of* Jarnkrok/Pulkkinen/Frk/Jurco/Sheahan.
-Resign: RFA's: Nyquist, Andersson, Kindl, Smith. UFA: Brunner. *I've penciled all five in at a $1M raise.
-Sign: M. Streit ($4.1M), B. Bickel *for example* ($1M), J. Mursak *for example* ($0.5M).
Leaves you with THIS roster (below) and about $8.4M left to spend on a top-line forward (or whatever?). There's no one I like set to hit the FA market, but we'll see who becomes available through trade or buy-out. Early names that excite me the most: Alexander Ovechkin, Rick Nash, Marian Hossa, Vincent Lecavalier, Brad Richards. Shall see.
My Custom Lineup
Pavel Datsyuk ($6.700m) / Henrik Zetterberg ($6.083m) / *?*F.A. or Trade*?* ($8.372m)
Gustav Nyquist ($1.875m) / Johan Franzen ($3.955m) / Damien Brunner ($2.350m)
Calle Jarnkrok ($0.900m) / Joakim Andersson ($1.875m) / Tomas Tatar ($0.840m)
Bryan Bickell ($1.000m) / Darren Helm ($2.125m) / Justin Abdelkader ($1.800m)
Cory Emmerton ($0.533m) / Jan Mursak ($0.550m) /
Niklas Kronwall ($4.750m) / Jonathan Ericsson ($3.250m)
Mark Streit ($4.100m) / Danny DeKeyser ($1.350m)
Jakub Kindl ($1.883m) / Brendan Smith ($1.875m)
Brian Lashoff ($0.725m) /
Jimmy Howard ($5.292m)
Petr Mrazek ($0.790m)
Buyout: Mikael Samuelsson ($0.000m)
Buyout: Kyle Quincey ($0.000m)
Buyout: Carlo Colaiacovo ($0.600m)
Buyout: Todd Bertuzzi ($0.625m)
Buyout: Jordin Tootoo ($0.567m)
Buyout: Jonas Gustavsson ($0.500m)
Buyout: Patrick Eaves ($0.400m)
CAPGEEK.COM TOTALS (follow @capgeek on Twitter)
(these totals are compiled with the bonus cushion)
CAP SPACE (23-man roster):- $0
Special Notes:
1) I like the idea of bringing Mark Streit in. He's been one of the most underrated defensemen in the NHL for a long time now. He'd give our PP the real QB it lacks on the blue-line, and improve that unit immensely. Then he's also pretty solid in his own zone as well. At 35 years old, I doubt he'd command much of a raise from his current $4.1M salary either. Would definitely rather have him than Quincey.
2) Franzen centering the second line. I LOVED Nyquist-Andersson-Franzen in the post-season. It, as our third line, was arguably our best line. I think it'd be even better next season with Mule in place of Andersson. And I think our third line would be pretty good too, with Andersson in between a couple of new kids - Tatar and Jarnkrok(?). I also love that it gets Pav and Hank together on a great top line, along with, hopefully, another great scorer. And I like that 4th line look of Abby, Helm and someone like a Bryan Bickell.
Edited by blueadams, 30 May 2013 - 04:57 PM.

subset: commoncrawl


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SHEPHERDSTOWN - The Sheperdstown Street Fest is one of the Panhandle's largest one-day, open air street events with live music, kids activities, food and fun.
Last year the festival saw approximately 6,000 event goers, and this year promises to be even bigger with more vendors, musicians and activities.
The festival opens at 10 a.m., and the first of nine bands will take the stage at 11 a.m. There will be two street stages set up for live musical entertainment - the Main Stage and the Library Stage. The Hillbilly Gypsies will begin the first concert of the day on the main stage, followed by The Woodshedders, Johnny Neel, On The Bus, and end with the festival's headlining band, Big Leg Emma. On the library stage, The Lady Dies, The Gypsy Ramblers, Christian Lopez and Joe Taxi, and Tabasco Bustelo will be performing as well.
While all of the outside activities are taking place, there will be a Kids Camp, sponsored by Morgan Academy held in McMurran Hall featuring nature based crafts presented by The Children's Tree House, kids's yoga with Jala Yoga, magic shows with Michael T., face painting, and family-friendly music performed by Tony M.
There will be a beer and wine garden located close to Hypnocoffee. Those wishing to purchase alcohol will first need to go to the I.D. Tent to purchase drink tickets before proceeding to the beverage tent. Drinks are $4 each, but a souvenir cup can be purchased for $5 which will include one drink ticket. Refills will be $4.
There will be more than 70 artisanal vendors and almost a dozen food vendors, plus the many local restaurants and shops will be open as well.
Fact Box
If You Go
What: Shepherdstown Street Festival
When: 10 a.m.-8:30 p.m. Saturday, June 29
Where: Downtown Shepherdstown
Cost: Free
For more information, visit www.shepherdstownstreetfest.org
Each year, the festival donates a portion of its proceeds to two non-profit charities - one that is local and one that is regional. This year's recipients are Bethany House and Good Sherpherd Caregivers.
Bethany House is a 24-hour, 7-day-a-week emergency women's and children's shelter servicing Morgan, Berkeley and Jefferson counties. Bethany House also provides case management assistance to homeless individuals and families.
Good Shepherd Interfaith Volunteer Caregivers provides informal volunteer caregiving to home-bound older or disabled Jefferson County residents. Its non-medical caregiving services are provided free of charge by volunteers who help with transportation to medical appointments, lawn maintenance, snow removal, friendly visits and phone calls, minor home repairs, grocery store trips, light housecleaning, and medical equipment loans.
The event will take place rain or shine and a full list of vendors, entertainers, sponsors and downloadable map of the festival can be viewed by visiting the event's official website at www.shepherdstownstreetfest.org.


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Amethyst Disco Dust (Pixie Dust)
Add glamour and radiance to your cakes or projects with Disco Dust (Pixie Dust). Disco Dust is a non-toxic extra fine glitter that will add a touch of color with lots of sparkle to your removable gum paste flowers, castle decorations, and more. Make your creations shine with Disco Dust (Pixie Dust)!
*Actual colors may vary from those shown due to picture editing process. Colored Dust are not a food additive and should not be considered as such.
Not Water Soluble. Non Toxic. Not suitable for Air brush use.
Weight: 5 grams
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BlackBerry 7 OS delivers speed, efficiency and UI enhancements and enables new hardware capabilities, including HD video recording, more fluid and responsive graphics, digital compass, and augmented reality. Browsing with the new BlackBerry 7 based smartphones is up to 40% faster than BlackBerry® 6 based smartphones and up to 100% faster than BlackBerry® 5 based smartphones.
quote: Are you trying to imply that iPhones are a good amount faster than Android phones? That isn't what I have seen in the wild.


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on January 17, 2013 - 1:00 AM
Preparing to see "The Impossible" was like preparing for an expedition. First, the proper equipment was necessary before the endeavor even began. Tissues, tissues and more tissues were stuffed into a larger-than-average-sized bag, not to mention the particular movie essentials, including, but not limited to, an unbiased mentality and an open mind. A good degree of mental preparation seemed necessary after a bit of research on the tragic tsunami that swept across all landscapes touching the mighty Indian Ocean. After settling into my cozy seat just in time for the anticipated previews, I was all geared up and ready to go; or so I thought.
As it turned out, the time I spent bracing myself for the epic historical film was wasted. Nothing could prepare me for the drama that unfolded on the movie screen and turned into my deepest level of astonishment. "The Impossible" is worth the wait and then some. It's a moving, surprising piece of art whose sentiments seem to emerge not from the screen but from the very depths of a hoarse, nostalgic echo that begs to be heard.
Directed by Juan Antonio Bayona, the film starts off at a relaxed pace, depicting the loving family of Maria and Henry and their three young sons. While the buildup is casual and somewhat peaceful, it fits far better into context after the groundbreaking wave that, though you know it's coming, shatters your emotional wholeness and brings forth that shard of humanity that you were unaware you even possessed.
Good luck fighting those tears. With breathtaking special effects and phenomenal performances, your heart is guaranteed to be ripped into multiple pieces, each shard of which goes out to a wife who wept for her husband or a father who lost his son. With Ewan McGregor's acting amounting to an emotional escapade as Henry, the emotionally distraught yet determined father, it didn't seem like the performances could get any better. Until the young Tom Holland, who plays the dynamic eldest son, Lucas, delivers extraordinarily, impressing audiences with his awe-inspiring talent. But no performance was delivered quite as well as that of Naomi Watts, however, whose stunning presentation practically made the movie. Watts, who has embodied such iconic characters as Rachel from "The Ring" and Ann Darrow of "King Kong," as well as an appearance in "J. Edgar" alongside Leonardo DiCaprio, was nominated for a Critics Choice Award for her role as Maria.
Be warned: This movie is not for the faint at heart. Its emotional roller coaster aside, the film's sluggish yet compelling revelations are showered with physical strain and a handful of gruesome images. Hospital scenes and gaping wounds drench the film, and some light nudity is depicted. Watts will have you gritting your teeth and wincing in discomfort by way of her powerful physical performance, which not only captures the struggle of her character but ultimately offers a view of the center of a natural catastrophe, something few of us could truly understand.
Prepare to be unprepared. If you plan on taking a trip to your local theater in the near future, skip your annual blindfolded point-and-pick method. Choose "The Impossible." You'll find that it really is worth the hour and 54 minutes it so humbly requests, though it deserves much more.
Rachel Whalen is a sophomore at Williamsville South High School.


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The haunting season is approaching, and the Lake Erie shores and islands have a number of spooky attractions in the works.
Sandusky State Theatre is to host nationally known paranormal investigators from popular television programs for lectures and ghost hunts at the theater, which legend says is haunted by at least four spirits.
Cedar Point's HalloWeekends are geared toward families and thrill seekers. For children, there is a themed parade, costume contest, Planet Spooky and a fun house. Adults have four haunted houses and six walk-throughs from which to choose. New this year are Eden Musee, a wax museum, and Cut Throat Cove, an outdoor pirate-themed show.
Visit Ghostly Manor, for the new Lake Eerie Fearfest. The mysterious legends of Lake Erie are brought together under one roof to create the area's newest haunted destination. Lake Eerie Fearfest is six acres of non-stop haunted action, including Darkmare, Caged, Quarantine and Eerie Chateau.
And there's more:
Ghost Walks with Victoria, now through Nov. 1; The Marshall Inn Bed & Breakfast, Port Clinton.
HalloWeekends, now through Oct. 28, Friday through Sunday only; Cedar Point, Sandusky.
Ghost Hunt with Firelands Paranormal Society, Oct. 4 and 31; Sandusky State Theatre, Sandusky.
Lake Eerie Fearfest, Friday (Sept. 28) through Oct. 31; Ghostly Manor Thrill Center, Sandusky.
"Deadly Harvest The Creature Walks Among Us" murder mystery, Oct. 12 and 13; Kelleys Island Venture Resort, Kelleys Island.
Ghost Hunters with Dustin Pari and Christopher Fleming, Oct. 13; Sandusky State Theatre, Sandusky.
Zombie Crawl, Oct. 19; various locations, Port Clinton.
ZomBay Walk, Oct. 20; Merry-Go-Round Museum, Sandusky.
Zombie Prom, Oct. 20; The Underground, Sandusky.
Ghost Hunter with John Zaffis, Oct. 21; Sandusky State Theatre, Sandusky.
Rogue Zombie Pub Crawl and Ball, Oct. 27; various locations, Port Clinton.
Visit shoresandislands.com for attractions, events and lodging details.


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Objectives | Program Requirements
| Academic Minor
The Environmental Studies Program offers an academic minor focused on
the examination of environmentally related issues from a variety of disciplinary
perspectives. With a foundation based in studies in philosophy, history,
and literature, the minor concentrates on social policy, values, and scientific
understanding with respect to the environment and stresses comprehension
and analysis of rapidly changing global and regional environmental conditions.
The curriculum prepares students to enter public and private organizations
that deal with today's pressing environmental matters.
The academic minor requires completion of 24 credit hours selected from
the anthropology, biology, economics, English, earth systems science,
philosophy, and political science courses listed below. Students must
maintain a cumulative 2.5 GPA in courses required for the Environmental
Studies minor. Additional course work is available in the chemistry, history,
and psychology programs, and in selected honors courses.
Students choosing a double major or minor in any of the fields included
within this minor may not apply a course to more than one major or minor
except in the case of BIOL 210 (Environmental Biology, LE).
For course prerequisites please refer to the course descriptions.
Requirement Description
Credit Hours
Required Courses
BIOL 210 Environmental Biology and Lab, LE
ESS 205 Earth Systems and Global Environmental Change
ENGL 357 Environmental Literature
PHIL 307 Environmental Ethics
PLSC 327 Environmental Politics and Policy
From the following courses, students must take six additional hours:
ANTH 252 Cultural Anthropology, LE (4)
BIOL 404 Ecology and Lab (4)
ECON 325 Environmental Economics (4)
ESS 101 Introduction to Geography (3)
ESS 110 Introduction to Geology, LE (3)
Certain Selected Topics (300 courses), Directed Studies (401 courses),
and Internships (440 courses) offered under participating programs may
also be suitable as electives. Students should consult a faculty member
in the Environmental Studies Program regarding the suitability of a particular
course and should get approval from the director of the Environmental
Studies Program before registering. Refer to the course descriptions in
each program for specific information and prerequisites. Titles of Selected
Topics courses are published in the course schedules for each semester.


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Former Marine lied about combat injury to defraud charities
Michael Duye Campbell admitted in federal court documents that he made up his story about being injured while on patrol in Iraq in 2003. Campbell, who aspired to be a professional golfer, told media outlets and veterans service organizations that he hoped to overcome a combat-related brain injury in Iraq and fulfill his dream of becoming a professional golfer.
But there was no brain injury and no overseas combat duty. Campbell served in the Marine Corps from 2000 to 2004 but never left the U.S. and was never injured in combat, federal court records say.
The Dallas-area golf enthusiast admitted in federal court documents filed Tuesday that he made up his story about being injured while on patrol in Iraq in 2003.
He did so to get money to pursue his dream of playing on the PGA Tour, according to federal authorities. Campbell agreed to plead guilty to mail fraud and could face up to 20 years in prison for defrauding charities out of at least $40,000. The plea does not become official until it is accepted by a judge.
Federal authorities say Campbell managed to dupe journalists, including those working for National Public Radio and Golf Magazine. The Dallas Morning News chose not to run an article about him in 2010 after discovering discrepancies between his claims and his service records. Read more here.


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We had Noah's kindergarten parent-teacher conference this week. His teachers said he is quiet in a good way, sets a good example for the other students (especially for the new little boy from Saudi Arabia named Turkey but they call him ToTo-- ah, we'll save that for another post!), and they gushed that he always always has a smile on his face.
Yesterday he recited the Pledge of Allegiance and my heart almost burst. I think this is the sweetest, most adorable thing ever in the world at this moment.


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National Alliance on Mental Illness
page printed from http://www2.nami.org/
(800) 950-NAMI; email@example.com
Research Revolution
January 19, 2009
An editorial in the international scientific journal Nature calls for a major revolution in mental illness research this decade.
While funding for mental illness research traditionally has lagged behind research for other illnesses, new biomedical science is expected to give researchers an unprecedented understanding of brain's biology this decade, which may improve mental illness diagnoses and therapies.
Today, both diagnosis and medications typically are used to address the late-stage development for an illness. For example, people with schizophrenia often are not treated until they are experiencing delusions. The earlier stages of mental illness appear much less well defined and are less well understood, and yet, early intervention would lead to better outcomes for people living with these illnesses.
In addition to shedding light on the biology behind the earlier stage of mental illness, the author notes that research also is needed to address the effectiveness and side effects of current medications, as well as environmental influences on mental illness.


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DUNCANSVILLE - The National Multiple Sclerosis Society will host Return to Romance on Feb. 13 at The Calvin House.
The event is being held in honor of the late John Carothers.
"He was more than a devoted husband and father of four children, John was a certified public accountant for over 35 years. John lost his struggle with MS in the fall of 2008,'' said Bonnie Carothers, his wife of 40 years. "John enjoyed life to his fullest and was grateful for every moment.''
Article Photos
Courtesy photo
The National Multiple Sclerosis Society's Return to Romance committee members include (from left): seated — Colleen DeLeo, NMSS representative; Gina Baird, co-chairwoman; Bonnie Carothers; Sandy Schwabenbauer, co-chairwoman; and Sharon O'Keiff, NMSS representative; back row — Jill Madden; Marcia Barnes; Denny Helsel; Larry Savino; Barb Savino; and Brittany Madden. Absent from the photo are Sharon Ciccarella, Robin Pellegrine, Peggy Cawthern, Sue Condrin, Peggy DeLeo, Devin Mullen, Louisa Lobre-Riley and Tom DeLeo.
Bonnie Carothers explained her husband loved playing golf and riding his bicycle. "He enjoyed playing bridge, but, most of all, he enjoyed spending time with his family and friends,'' she said.
Bonnie explained that no one had the sense of humor that John had, and he had a nickname for everybody.
John was diagnosed with MS at the age of 29, and over the years his MS progressed so that it was harder for him to enjoy the things he loved to do. "John was an inspiration to all who knew him,'' she added.
Tickets for the Return to Romance are $100 per person or $200 per couple. Tables of eight also are available.
The event features hors d'oeuvres, dinner and dancing to Rick Hirsch Music, a silent auction and more. It is black-tie optional. Carolyn Donaldson from WTAJ will be the emcee.
For tickets or more information on corporate sponsorship or to make a donation, contact Sharon O'Keiff at the NMSS, Keystone Branch office at 696-1017 or mail your donation to NMSS 506 Third Ave., Duncansville, PA 16635.


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Closed Captioned
Alongside knitwear designer and teacher Sunne Meyer, you'll learn the basics of stranded colorwork, and progress from beginner to more advanced techniques. Knit a pair of simple yet striking Evergreen Lake mittens as you add a second color with ease and an afterthought thumb in a breeze. Master the two-color cast-on and secure your floats as you create the beautiful and approachable Sawatch mitten complete with a braided trim and gusseted thumb. Work an elegant picot edge as you conquer three-color knitting with the San Isabel mitten, and even find out how to create perfectly matched stripes with jogless jogs. Plus, learn Sunne's expert tips for fitting your mittens, troubleshooting mistakes, blocking for a professional finish and adding fun embellishments!
Meet your instructor, Sunne Meyer, and jump right into choosing your needles, reading the mitten patterns and learning about the management of multiple colors in your knitting.
Begin your stranded colorwork adventure with the two-color Evergreen Lake Mitten. This easy accessory features a tidy turned hem, an afterthought thumb and simple finishing. Sunne walks you through all the techniques you'll need.
Try your Evergreen Lake Mitten on for size, then finish the mitten top and master the afterthought thumb.
The intermediate Sawatch Mitten kicks your knitting skills up a notch with the addition of braided trim, gusseted thumbs and a grafted bind-off.
Once you've mastered two-color knitting, give three a try! The stunning San Isabel Mitten is intricate yet achievable. You'll love the picot detailing at the cuff.
Dropped a stitch or missed a color change? No worries; Sunne shows you how to fix mistakes, then shares tips for closing gaps, weaving in ends and blocking your handiwork. Finally, she'll show you how to add pizzazz to any mitten with a duplicate-stitch embellishment.
"... if you want great instruction of the technique, she has it down pat. She also offers great guidance and is great all around. I am glad that Craftsy added this class. "
- AndyV
New York, NY


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The Railway Man
Directed by Jonathan Teplitzky
Starring: Colin Firth, Nicole Kidman, Hiroyuki Sanada, Stellan Skarsgård
Rated R for disturbing prisoner of war violence
1 hr. and 56 min.
The Railway Man is a movie that, like its protagonist Eric Lomax (Colin Firth), will struggle to survive and live another day with an American audience. Why, you ask? Well, for one thing, the story is so dark and brutal, just reading the film's description will scare most people off. WWII, Japanese torture, PTSD. Not very entertaining.
Second, it's a small British film being launched amid expensive American films such as Spiderman 2, Godzilla and X-Men: Days of Future Past. When one must decide between war and human torture or comic book material, which seems the most likely choice? While I admit the subject matter is tough to watch — beatings, starvation, waterboarding — what makes this film compelling is the story itself. A true story no less about Lomax, who barely survived a Japanese WWII prisoner-of-war camp where he helped build what became known as the Death Railway between Bangkok, Thailand and Burma (now Myanmar).
It was 1942. Thousands of British soldiers and other Allied troops were captured when Japanese forces overran Singapore. Churchill called it "The greatest disaster ever to have befallen the British Empire." Lomax, a 21-year-old signals engineer and railway enthusiast, was one of those prisoners.
Director Jonathan Teplitzky starts the story decades later and uses flashbacks to piece together what was, what is, and what is to come.
40 years after the war, Lomax marries Patti (Nicole Kidman), whom he accidentally meets on a train. But on their wedding night, she discovers a dark truth about her husband. He has nightmares that literally throw him out of bed. He's angry. He won't talk about his past. She is forced to ask one of his war comrades, Finlay (Stellan Skarsgård), about what they endured in Thailand.
Finlay shares their story and reluctantly gives Patti some important information. He has learned that one of their tormentors, Nagase (Hiroyuki Sanada), is alive and actually working at the war museum in Thailand where he and Lomax were tortured. After he shares his discovery with Patti, she must choose whether or not to share it with her husband.
There are a lot of moving parts to this film. Teplitzky has done this intentionally, I think, to give the viewer a sense of Lomax's own chaos. Trying to live in the present and the past, trying to appear as a quiet English gentleman obsessed with English history and railways even as he suffers from flashbacks.
Academy award-winning actors Firth and Kidman painstakingly re-create the dynamics between their gentle, more amiable selves and their dark underworlds. It's a matter of understatement on one hand and brutality on the other. For both, the prime communication takes place with facial expressions that probe, hide and fight off a more chaotic reality.
But it's the ending that makes this film not only compelling but, given our current experiences with soldiers and PTSD, highly contemporary. When war ends, does it really end? Do dreams of death and revenge really point to something else? A need for love and forgiveness? A desire for self-expression and human contact? And when two opposing forces, both damaged by the same war, come back together, what fires result?
Which is why this film carries great weight. The Railway Man, like soldiers who suffer from war trauma, is easy to overlook, and what we peek at makes us afraid and willing to turn a blind eye. Still, Teplitzky and Lomax seem to be asking one of the crucial questions of our generation: When you people someone to war and they come back wounded, what are you going to do about it? The Railway Man challenges us as an audience to sit up and pay attention to a horrible truth and the road one man took to survive and forgive.


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The expedition lasted for months. During this time, Mee lived among the indigenous people and endured multiple hardships, from malaria and hepatitis to scores of insects, giant anacondas, and nightly attacks by vampire bats. Rather than being deterred by the untamed tropics, Mee was invigorated and inspired. Coming back from this first expedition, she said "Now Amazonia was in my blood." Mee. In Search of Flowers. p 43.
The trip proved artistically fruitful for her. Mee returned to São Paulo with a portfolio filled with sketches, dramatic landscapes, and meticulous botanical studies. She presented her work to the city's Botanical Institute. Impressed, the botanists sponsored an exhibition of her paintings. Mee continued showing her work throughout 1958. An exhibition in Rio de Janeiro brought her to the attention of many well-known professionals such as landscape architect Roberto Burle Marx, Dr. Alcides Teixeira, the Director of the Botanical Institute of São Paulo,and Dr. Lyman Smith of the Smithsonian.
Smith, a world authority on bromeliads, invited Mee to join him on a project cataloging tropical flowers for his Flora Brasilia series. Working side-by-side with a botanical authority like Smith, Mee rapidly acquired a specialist's knowledge of bromeliads and a particular brilliance in depicting them. On later expeditions into the Amazon, using her then-experienced field botanist's eye, she discovered three new species which were named after her: Aechmea meeana, Neoregelia margaretae, and Neoregalia meeana.
Smith and Mee published their collaborative volume, The Bromeliads, in 1969. In the introduction, Smith wrote "As you look at these pictures, remember that they achieved their artistic effect and scientific accuracy because Margaret Mee was not satisfied to drag a dying plant back to the comfort of her studio nor to reconstruct from a dead one. Instead, she met them where they lived and painted them there, evolving a highly successful technique through trial and error." Smith, Lyman B., and Margaret Mee. The Bromeliads. South Brunswick and New York: A.S. Barnes & Co., 1969. p 5.
Mee began her relationship with Dumbarton Oaks around this time. After her third expedition (1964), Mee left the São Paulo Botanical Institute and transitioned to painting full-time. The evening lecture she gave at Dumbarton Oaks in April of 1967 helped introduce her work to a much larger audience, including Dr. Leonard Carmichael of the National Geographic Society. This encounter led to the Society sponsoring Mee's next expedition, this time to a little known Amazonian mountain, the Cerro da Neblina – the Mountain of Mist.
In total, Mee made fifteen journeys to remote areas of the Amazon; some were scientifically groundbreaking, others an artist traveling for subjects. She received a Guggenheim Fellowship, and the Brazilian government funded a folio of paintings. Shows of her work continued, culminating in a watershed exhibition at Kew Gardens in 1988-1989. The Kew Gardens exhibition coincided with the publication of her book, In Search of Flowers of the Amazon Forests, based on excerpts from her travel diaries covering expeditions between 1956 and 1988. The later diaries documented the destruction of massive parts of the forests. Mee became a significant spokesperson for conservation of the Amazon, helping to document the devastation through her work. During the thirty years of her career, she saw Amazonia shrink from a vast wilderness to an endangered ecosystem encroached by civilization and commercial exploitation.
While in England in 1988 for interviews and lectures to raise awareness for the Amazon and support the Kew exhibition, Mee was killed in a car accident. Her activism may have ended, but her work lives on. A unique combination of scientific accuracy and artistic beauty characterizes her paintings, and Mee is considered by her peers to be among the best in the field of botanical illustration. Parts of the Amazon she so loved are now gone, and many of the plants she carefully rendered are extinct, but her paintings remain a testament to the endangered beauty of the rainforest.
The Dumbarton Oaks Rare Book Collection is pleased to present twenty-one of Margaret Mee's paintings in this online gallery.
All photographs of Margaret Mee are used courtesy of South American Pictures Collections, Tony and Marion Morrison, Margaret Mee Collection.]]>


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Bruce Chen Finds Out Javier Baez Can Do Whatever He Wants
Bruce Chen was torched for five home runs (two by Javier Baez and one each by David DeJesus, Alfonso Soriano, and Alberto Gonzalez) over five innings, as the Cubs cruised to an 8-3 vistory over the Kansas City Royals in Cactus League action this afternoon at Dwight Patterson Field at HoHoKam Park in Mesa, AZ.
Baez took Chen deep with a solo HR onto the berm beyond the LF fence with two outs in the 1st, and then again with another solo HR (this one a Monster Jam) over the scoreboard and into the parking lot with two outs in the 5th, and has now hit four home runs in his last five plate appearances (he hit home runs in his final two PA versus Team Japan yesterday, including a walk-off two-run HR in the 9th).
LHP Hisanori Takahashi got the start for the Cubs and worked four solid innings (53 pitches - 15 strikes), allowing one run (a Mike Moustakas solo HR over the bullpens in RF) on five hits (three singles, a double, and the HR) and one walk, with one strikeout and a 7/3 GO/FO. He also picked a runner off 1st base.
The Cubs have stretched-out Takahashi as a starter over his past three appearances, and while he seems to be suited for that role, there does not appear to be a spot for Takahashi in the Cubs starting rotation at this time, even if Matt Garza (strained lat) and Scott Baker (TJS rehab) are not ready to start the season. The Cubs might have a "piggy-back" role in mind for Takahashi, where he would follow Scott Baker to the mound if Baker does not have his pitch count up to necessary levels by the end of Spring Training. (Baker would start the game and go as far as he can, and then Takahashi would follow and pitch multiple innings if necessary).
RHRP Michael Bowden took the mound in the 5th and pitched two shutout innings (26 pitches - 18 strikes), allowing two hits (a triple and a single) and no walks. He struck out two (the last two hitters he faced), and got the other four outs on pop ups or fly balls.
Bowden has pitched OK (not great but not bad) so far in Cactus League games, but he has an advantage over most of the other contenders for middle relief jobs in the Cubs bullpen because he is out of minor league options and thus cannot be sent to the minor without being exposed to Outright Assignment Waivers (which are irrevovable), but even if waivers were to be secured, Bowden can refuse an Outright Assignment and elect free-agency because he has been outrighted previously in his career. So the Cubs have to make sure to get a good read on what Bowden has to offer now and in the near future.
Shawn Camp followed Bowden and labored through a 27-pitch (only 12 strikes) 7th. Camp surrendered a single and a walk to start the inning, and eventually allowed a run on a two-out infield single, but at least he was able to get out of the inning without further damage.
Kyuji Fujikawa pitched the 8th inning and allowed a run on two hits (a lead-off double by Brandon Wood, a single, and an 8-6 RBI FC where CF Dave Sappelt just missed making a spectacular diving catch, but still was able to get to his feet in time to make an accurate throw to 2nd base that forced the runner who was on 1st).
Carlos Marmol worked a fast 1-2-3 9th (two deep fly ball outs and an infield pop up).
Six of their eight Cub runs resulted from the five home runs (Soriano hit a two-run dinger, and the other four were solo shots).
The Cubs scored another run in the 3rd, as Alfonso Soriano walked and later scored on a throwing error by the KC second-baseman, and collected their final tally of the day in the 6th on a two-out Justin Bour RBI ground single through the box that followed hits by Rafael Lopez and Christian Villanueva.
The Cubs made several roster moves yesterday, optioning IF-OF Junior Lake to Iowa, 3B Christian Villanueva to Tennessee, and OF Jorge Soler to Daytona, although they can continue to play in MLB Cactus League games (Villanueva and Soler played in the game at HoHoKam Park today, but Lake will be out 4-6 weeks with a rib injury).
The reason those moves had to be made yesterday is that normally an injured player cannot be optioned to the minors, but the one exception is a player who did not accrue any MLB Service Time the previous season, as long as the player is optioned to the minors no later than the 16th day prior to MLB Opening Day (which was yesterday).
By optioning Lake, Villanueva, and Soler to the minors yesterday (and Matt Szczur, Trey McNutt, Logan Watkins, and Rob Whitenack earlier this week), the Cubs covered themselves in case any of the seven (none of whom accrued MLB Service Time last season) are injured prior to being optioned (as happened with Lake) or in an MLB Cactus League Spring Training game.
If the Cubs did not option the seven to the minors by yesterday's deadline, they would be taking a risk that the player could be injured prior to MLB Opening Day. And if that happened, the Cubs would have to place the player on their MLB 15-day or 60-day Disabled List and pay the player at the MLB salary rate (about $2,650 per day), rather than the lesser minor league "split salary" rate (about $430 per day for Lake and Szczur, and about $215 per day for the others), with the player also accruing MLB Service Time for days spent on an MLB DL during the MLB regular season (which could eventually affect when the player would be eligible for salary arbitration and/or free-agency).
But because they were optioned to the minors by yesterday's deadline, any of the seven can be placed on the Disabled List of the minor league club to which the player was optioned. And this is exactly what will happen with Junior Lake. He will be placed on the AAA Iowa DL at the start of the season (and be paid at the minor league "split salary" rate), will probably spend about a month at Extended Spring Training at Fitch Park while getting back into playing shape, and then will be reactivated when he is ready to play.
I know they're projecting
I know they're projecting Baez and Soler to join the Cubs in 2025 or something, but I get a strong feeling Baez is going to get up to the big leagues more quickly than a lot of people are saying. That said, Theo was on WGN today during the game saying he likes to see minor leaguers get a bazillion ABs, so who knows. Still, I saw that home run today and the dude really smacked it.
On another note, during the WBC the MLB network did an at bat comparison of Rizzo and Josh Hamilton, and they looked like twins at the plate with their swings. Kinda fun.
Theo should just respond
Theo should just respond "service time service time service time." I don't think there's any chance of seeing Baez up before June 2014 on a non-September roster.
A period after the 2014 would
A period after the 2014 would have sufficed. No need to rush things.
BB America seems bullish
BB America seems bullish about Baez showing up early in his career...these projections generally include "first cup o coffee" stints, not simply "you made the team out of ST and it's your job"
16 Javier Baez ss, Cubs
Age: 20. ETA: 2014.
34 Jorge Soler of, Cubs
Age: 21. ETA: 2015.
Just saw the game on dvr,
Just saw the game on dvr, Javy is awesome.
I have the feeling Javy
I have the feeling Javy agrees.
dude has the mlb logo tattoo
dude has the mlb logo tattoo'd on the back of his neck...he's obviously ready now.
Some teammates razzed him by
Some teammates razzed him by adding a "Rookie of the Year" decal on the back of his car.
In all seriousness, if
In all seriousness, if Valbuena goes down, he's the best healthy 3B option in the system at this point. I suspect he'd do better against MLB pitching than Villanueva in 2013.
If Valbuena goes down down
If Valbuena goes down down the season is lost.
/st patricks day
//drinkign early
Az Central.com article on
Az Central.com article on Starlin Peralta and his stay with the Dbacks
Hey AZ Phil (or anyone really
Hey AZ Phil (or anyone really)-
Just saw on BA's weekly transactions (http://www.baseballamerica.com/blog/prospects/2013...) that both five guys were recently released. Two of them surprised me- RHP Arturo Maltos-Garcia and RHP Austin Urban. You mentioned Urban recently as having finally pitched and looking good. Plus Maltos-Garcia was a TJ rehab guy who had put up really nice numbers prior to the injury and I believe was given a higher than normal bonus. Any word on if the report is true and why they would have been cut.
just watched a recent
just watched a recent Simpsons episode: Black Eyed, Please.
Cub moment when Lisa goes to detention (because she complained that her substitute teacher was bullying her) and asks the detention regulars: Why does someone become a bully? They answer...Jimbo says: "Neglect.". Dolf says: "Abuse." Kerny says: "I'm a Cubs fan."
also some funny Vin Scully rain delay parody about ducks swimming on the tarp
I thought Nelson said it,
I thought Nelson said it, either way it was funny'
Stewart going for another MRI
Stewart going for another MRI on quad injury...keep hitting those HR's Baez.
nice to see s.baker on the
nice to see s.baker on the mound...WGN game, btw.
bottom 1st...0 out...OAK up
bottom 1st...0 out...OAK up 0-3.
not so nice to see s.baker on the mound anymore.
and Texas puts up a 3 spot
and Texas puts up a 3 spot against CVillaneuva (and still batting) in Vegas
s.baker done...1 out, 2 on,
s.baker done...1 out, 2 on, bottom 1st. he was on a mega-low pitch count anyway, and probably wasn't going to go more than 2ip (3ip if lucky/efficient).
0.1ip 3h 2bb 0k...3er
trainer out...r.dollis seems
trainer out...r.dollis seems to have a blister/finger issue and he's out.
via b.miles
"Rafael Dolis was removed from Sunday's game with a blister issue."
Dolis audio...
I clicked on the link before
I clicked on the link before I saw who posted it. I would have known, had I looked.
Is anyone else bugged by the
Is anyone else bugged by the numerous media stories that report that Almora's hamate bone was being removed? As I understand Dr. Hecht's description, only the fractured hook fragment was being taken out -- not the entire hamate. The removal of the entire hamate would be another thing entirely. Sloppy reporting. OK -- end of pet peeve rant.
Sorry to go all medical lingo on everyone but (I don't have time to soften this post up)...
Excision of the hamate bone in it's entirety is not done because it would destabilize both the 4th and 5th metacarpal connection to the wrist. If you watch the last link from my Hamate article one more time (the video slideshow), the presenter discusses fractures of the body of the hamate (which would be what you are referring to as 'entire' hamate) and shows techniques to fix that fracture with temporary wire fixation. The hamate body is never excised and if it were that comminuted (shattered) they would let it heal with some distortion (or with supplemental bone graft) but would still put pins in to keep the alignment of the 4-5th metacarpals to nearby wrist bones intact. The key is to keep the stability to the adjacent metacarpals as they are important in power grip (as opposed to fine detail grip coming from the 2-3rd metacarpals).
The hook of the hamate IS excised because when fractured. It typically does not heal as the area of fracture impairs the local blood supply to the hook portion of the bone and the healing of bone to bone just won't occur (called a nonunion or malunion). Thus leaving residual tenderness in the palm and making it painful when gripping a bat. The anatomic functions lost when it is excised are small.
The hook of the hamate is an attachment site for a portion of the transverse carpal ligament (TCL) which is a support for the carpal tunnel. The carpal tunnel is seen on the cross sectional CT imaging (also a previous link in the article) and all the flexor tendons and the median nerve pass underneath the ligament. The TCL is divided longitudinally when carpal tunnel syndrome surgery is performed to relieve pressure on the entire carpal tunnel contents and specifically the median nerve. On the little finger side of the hook of the hamate are the ulnar artery and nerve. Removing the hook does not affect them unless the surgeon isn't careful about those structures. Local ulnar nerve damage is one of the complications of this surgery and fortunately it is a rare event.
That was pretty much my
That was pretty much my understanding after viewing the links you gave and reading your post. None of the procedures illustrated a removal of the hamate. In fact, they seemed to emphasize the lengths a surgeon would take to fix the fracture with wire fixation in the case of a fracture of the body of the hamate. As I mentioned before, sloppy medical reporting bugs me.
m.owings (WAS) .400 (10/25),
m.owings (WAS) .400 (10/25), 3 doubles, 2 hr, 1bb, 6k
...shame he's not pitching anymore being a 2-way player. he'll probably have to go to AAA to begin the season as a hitter-only.
Rivero gets $3.1 million to
$3.1m for a 1-pitch, high
$3.1m for a 1-pitch, high walk, 25 year old cuban relief pitcher...sweet.
great news...
great news...
"Scott Baker woke up with elbow soreness Monday after his Cactus League debut and will undergo an MRI."
Because the fees for MRI's
Because the fees for MRI's are so high ($2500-$3500 for one or two views without contrast), it seems to me like some of this is just padding the radiologists pockets as well as the owners of the technology. I wonder who bears these expenses anyway? 100% on the Club? It is insane now, but I guess they just protect themselves - and to a lesser extent - "the investment".
Too bad Gayle Sayers didn't have all this technology available to him.
"Too bad Gayle Sayers didn't
"Too bad Gayle Sayers didn't have all this technology available to him."
Also too bad that my dad didn't have current cancer fighting technology available to him in 1967 when he developed Hodgkin's lymphoma. I'm grateful for medical advances and it's a bittersweet feeling to think of what was lost to medical conditions that nowadays would be considered almost routine.
d.sappelt hits his 3rd homer
d.sappelt hits his 3rd homer of spring...cubs are 2nd only to the M's with ST homers...woo spring.
also, e.jackson is having a nice day
6ip 3h 1bb 3k 1er (throwing 94+mph)
cubs lead 4-1 after 6.
...also lillibridge is almost a sure thing to make the club...2/3 today, .478 ST ba...multi-position...etc.
Cant wait for the Lilibridge
Cant wait for the Lilibridge bobble head day.
They should have an Ian
They should have an Ian Stewart bobblehead day, too. All torso and bobble, no limbs. Maybe just frayed arm and leg areas of the uniform where they should be.
at least he'll only cost $1
if the trend continues at least he'll only cost $1.8m to sign next year...woo.
he's made $4.5m the past 2 seasons to hit .183/.272/.289 in 338 PA...getting $2m this year.
I imagine his head will only
I imagine his head will only bobble on one plane.
the best part was watching
the best part was watching him do what others had a hard time understanding...no wait, that sucked...because he got 200+ PAs to show off his crap swing before he was shut down...much like the showcase he put on with the swing the year before.
some of us weren't fooled by a good spring last year while others where celebrating impending awesomeness.
Are we still talking about
Are we still talking about bobbleheads?
technically, yes.
technically, yes.
Luckily even though you may
Luckily even though you may not have Ian Stewart to push around anymore this year, you *will* have Scott Feldman!
Single-plane back patting.
Single-plane back patting. Cool.
...and ryan theriot is still
...and ryan theriot is still a singles-hitting little shit.
Casey McGehee Redux
Casey McGehee Redux
Brewers manager Ron Roenicke said Monday that Blake Lalli is a candidate for the Opening Day roster.
really crap fan showing out
really crap fan showing out in SF for tonight's WBC netherlands/dom.rep. game in SF...looks like a scattering of a few thousand...maybe 4-5K at best.
Too bad they can't move it
Too bad they can't move it based upon who is playing. In the Bronx that game draws 20-25K.
Another good site I don't know has ever been considered would be Milwaukee. Midwesterners in March are starved for legitimate competitive baseball.
Milwaukee would be great.
Milwaukee would be great. Lots of hotel rooms, good food, good local beer,and saloons on Blue Mound Road that would love to have business at this time of year. BTW, try Burke's, new on Blue Mound; my daughter and family live around the corner and really like the food, drink, and vibe. WBC would be great for them. (Milw also has lots of Asian and Latin-American restaurants, and if Serbia ever fields a team, they'd find a place to eat.)
In mid-summer, too. I speak
In mid-summer, too. I speak as a Cubs fan, of course.
Nothing some blackout rules
Nothing some blackout rules can't fix.
nice the Cubs are crushing
nice the Cubs are crushing even the slightest bit of hope right at the start of the season...
Stewart to DL with fluid in quad, Baker's throwing program shutdown
so they should start the season with this rotation that goes 2 deep (maybe 3 if you really like Feldman): Samardzija, Jackson, Feldman, Wood, Villanueva
and then a lineup that will try to score runs wth Valbuena, Barney, Castillo and a pitcher taking up 45% of the Ab's...
I give myself until May 1st to still be interested in the daily outcome of games.
This is the risk with signing
This is the risk with signing "rehabbing" players. In most cases the player gets paid anyway. The Club gets nothing. What a great country!
The team has the makings of 90+ losses again.
certainly wouldn't surprise
certainly wouldn't surprise me, stupid Astros and possibly Marlins will cost the Cubs a chance at the #1 pick though.
and despite my disappointment on wasting yet another season, I do think they're well on their way to building that perenial winner that we all wish for...
nice story on Soriano mentoring the kids...wish he worked as hard at getting a lighter bat a few years back.
MLB Owners...still evil
"The first attempt to do so
"The first attempt to do so (eliminate pensions of non-uniform wearing personnel), initiated last year by a small-market owner, never came to a vote after Chicago White Sox owner Jerry Reinsdorf chastised his brethren for being petty with the lives of ordinary people given the riches produced by the sport."
I had a friend who worked for both the White Sox and the Bulls -- he said that Reinsdorf was a generous and fair guy to work for and treated his employees well.
have heard he's good to his
have heard he's good to his employees, except those that put on a uniform :)
He seems to detest the player union...but glad he has some ounce of morality in those rich, old bones of his.
I always thought he should
I always thought he should have given Jordan a chunk of the Bulls, but to a guy like Reinsdorf that's probably communist. But overall he seems to pay pretty good at the professional sports level, and he's got quite a few championships under his belt. As Chicago owners go, as much as I'm not crazy about the white sox (I don't hate them, either - my family had too many sox fans as I grew up on the south side - I was the lone rebel in fact), he's been pretty good.
"but to a guy like Reinsdorf
"but to a guy like Reinsdorf that's probably communist"
Except when Comrade Jerry is having state build his park and restaurants within there.
Ha! Good point!
Ha! Good point!
good look at minor league
good look at minor league park factors...
FSL hardest league to score runs in over the last 5 years...good luck Baez and Soler.
PCL is very hitting friendly, although Principal Park is near the bottom as a run scoring environment
Southern League is about the middle to slightly conservative, although the Smokies park is the friendliest hitting environment in that league (or least friendly pitching environment depending on your point of view)
FSL very unfriedly as mentioned, although Jackie Robinson skews slightly hitter friendly for the league
Midwest League around the same as Southern League, Chiefs park is near the bottom and Kane County isn't much better
Northwest League is quite hitter friendly, no ballpark factors were listed though.
"Cubs acquired OF Jose Dore
"Cubs acquired OF Jose Dore from the Padres for a player to be named later or cash considerations."
Cubs traded for 1B/OF Jose Dore from the Padres for a PTBNL or cash
Dore will play his age 21 season this year...8th round pick in 2010 draft.
"hey, ronny cedeno...you just
"hey, ronny cedeno...you just hit .290 with a .371 ob% with a double and a homer for STL this spring...what are you going to do now?"
"get released!"
Can he play 3b? Sigh.
Can he play 3b? Sigh.
Levine says don't expect
Levine says don't expect Marmol or Soriano traded before the start of the season, particularly because of all the injuries. Cubs looking for utility player that can play both infield and outfield.
better showing for tonight's
better showing for tonight's WBC final in SF...could be better, though.
looks like they have 10-15K...it's a bit hard to tell, though the park is filled out a lot more tonight (especially in the bleachers and lower levels).
Recent comments
Meh, I messed that up. Mets are in.
Cards and Giants can still tie though.
Kershaw gets hurt by his defense and gave up 2 more runs. Blach has 8 shutout innings.
Mets already won as did Cards.
tomorrow is gonna be helluva fun if Giants hold on. We're all rooting for a 3-way tie I presume.
good news is now 5 K's for Lester through 4 (in a quest for 200 for season). Bad news is he's already at 86 pitches.
be curious how long Maddon sticks with Lester to try and let offense get back into it and get him the win (4-2 as I type, was 4-0)
Fwiw, he needed 2.1 IP to cross 200 for season so he got that at least. He also needs 9 K's for 200K's on season and he has 4 through 3.
cubs score 2 runs thanks to predictable reds pitching and horrible CIN defense...cubs only down by 1 now. heyward even got a gift 2rbi double out of an easy popout. neat.
something named Ty Blach has outpitched Clayton Kershaw through 6 innings (1-0 Giants).
not that finishing 2nd place will matter much nor did this game, but have to think if Hendricks pitches well tomorrow, he could leapfrog Lester in Cy Young voting. Don't see anyway Scherzer doesn't win it regardless and it doesnt' look like Lester has any incentive clauses that matter. Also might give Cueto some votes.
Rather remarkable how many teams have really good 1-2 options this year.
Nats: Scherzer and Roark (and Strasburg was great before injuries)
Cubs: Lester and Hendricks (and Arrietta is still damn good just not as consistently lately)
pretty much what I'm gathering from this thread is that it doesn't matter who you play in 5-game series, but no one wants to have to deal with Cardinal fans if we end up losing.
I can respect that.
first game for lester giving up more than 2 runs since july 24th. hell of a run.
doh, yes...dunno what happened there. jake arrieta is all "bro wut?"
lester going for #20...cubs haven't had a LH (thanks jpep for the correction) 20 game winner since d.ellsworth in 1963.
fwiw, all the games are free on mlb.tv
Short rest for MadBum would be 2 days. WC game is Wed., Games 1 & 2 are Friday/Saturday.
A left-handed one...
J-Hey not finishing with an offensive onslaught.
If Geoff Blum could be a Playoff hero, there is hope still...
Giants scare me. I think you're wrong about Bumgarner, he would pitch on short rest for Game 2 and then full rest for Game 5. Cueto would go Game 1, then short rest in game 4. Add in some really tough outs in that lineup and I want nothing to do with them. With that rotation they can easily steal a series.
Cards are a tough matchup. The rivalry evens out their comparable lack of talent. And like someone said, they love HRs, which is how to beat the Cubs. The upside is that I would feel really good about Lester twice against STL.


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Top Definition
A type of transmission used in newer cars as a compromise between the sporty side of a manual, and the easy shifting of an automatic. Most cars with this type of transmission are more expensive. The compromise is basically a gear selector where a button us pushed to move it to the right, then up and down in a sequential manner.
Hey that guy got shiftronic on his BMW.
Wow, whats his IQ?
About 14
Wow, whats his IQ?
About 14
Por James Hemma 23 de enero de 2007
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text:
Serves 4 |
Prep Time 5 minutes |
Cook Time 3 minutes
4 cups leftover, cooked organic brown rice
4 packets Eden Sencha Green Tea
1 tsp Eden Wasabi Powder (Japanese Mustard), mix with 1/4 tsp hot water to form a paste
1 sheet Eden Sushi Nori, cut into 2 inch long strips
1 1/2 tsp scallions, finely chopped
4 cups water
1 Eden Umeboshi Plum, remove pit and chop pulp fine
Place hot rice in individual bowls. Place equal amounts of wasabi paste, nori strips, bonito flakes, umeboshi plum and scallions on top of the rice. Place water in a saucepan and bring almost to a boil. Turn off flame, place tea bags in the water and allow to steep for 1 to 2 minutes. Pour 1 cup of hot Eden Sencha Green Tea over each bowl of rice. Stir and serve. Eden Genmaicha, Kukicha, or Hojicha may be used in place of Sencha Green Tea.
Note: Eden Bonito Flakes make a very nice garnish for this dish.
Eastern, Gluten-Free, Good/High Fiber, Good/High Protein, Japanese Food, Low Fat, Macrobiotic, No Sweetener Added, Sea Vegetables, Tea, Wheat-Free, Whole Grain


text:
ROCKFORD — NIU released the names of students from the College of Business who earned a spot on the fall 2013 dean's list. Business students named to the list include Derek Anliker, Belvidere; Kayla Burton, Belvidere; Jerald Carlson, Rockford; Jacob Davenport, Geonoa; Daniel Hannan, Rockford; Lane Hribal, Loves Park; Kayla Jacobson, Loves Park; Jesse Laseman, Caledonia; Kawing Lee, Loves Park; Christopher Lohse, Rochelle; Jamie Mortlock, Kirkland; Morgan Quinn, Rochelle; Cori Stewart, Rochelle; Peter Ratkovic, Rockford; Brian Rawson, Rockford; Jonathon Padron, Loves Park; Rebecca Wakenight, Polo; Nathaniel Wilson, Loves Park; Joshua Wood, Rockford; and Nicholas Zawislak, Loves Park. To receive this honor students must earn at least a 3.75 grade point average and complete a minimum of 12 semester hours. For information: niu.edu.
Location, ST | website.com


text:
See local artist Sarah Jaffe through the years
Denton native Sarah Jaffe has not only changed her tune throughout the years, but her look as well
Local singer-songwriter Sarah Jaffe reinvents her sound
Jaffe treads softly, band blasts it out
10 local acts to see at 35 Conerette
Concert review: Denton-based Sarah Jaffe captivates crowd at Granada Theater
Pop music review: Florence + the Machine astonishes with vocal prowess at sold-out Dallas show
CD review: Dallas' Norah Jones chills and unnerves on stunning new 'Little Broken Hearts'
Pop music review: The Fray tries to join the ranks of rock's sensitive piano men
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The Hearst Olympic Team takes in the sights around London during the 2012 Summer Games.
Full CoverageBreaking News
Image Gallery: Sights around London
Hearst Olympic Team takes pics in host cityUPDATED 2:09 PM CDT Aug 12, 2012
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5 Revenge Products: A Buyer's Guide for Psychopaths
#2. GPS Helmet
Kajimoto Laboratories via Treehugger
There are all sorts of mundane concerns that arise during the course of a vengeance bender: How do you isolate your victim? What's the best stage for your theater of despair? What outfit should you be wearing -- a torn devil costume, to let Gary Woobarth know that you are Satan himself come to claim his prize, or the bright green MC Hammer pants and Hypercolor T-shirt you wore to the zoo on that fateful day in 1991, to let him know that you have not forgotten his transgressions? Well, with the GPS Helmet from Kajimoto Laboratories, the one thing you won't have to worry about is guiding Gary to meet his doom. The helmet comes with two clips that fasten to the user's ears and tell the wearer which direction to go by painfully tugging on one or the other. Just imagine the fear and tension Gary Woobarth will build up as he's guided blindly along the road to his certain demise by the merciless, crab-like pincers of the robot strapped to his skull!
#1. Bitchin' Flamethrower Gloves
These are fully functional flamethrower gloves. I don't know what more you could possibly want from commerce, if it's not fully functional flamethrower gloves.
Field Test
History is a vital component of revenge: I mean, that's what it's all about, right? History. Let me clarify a few things, just so you have a better idea of what I'm looking for in these products:
March 27, 1991, The San Diego Zoo.
Mrs. Davis' fifth grade class was visiting for their annual field trip. Most children were there simply for a good time. A few labored under foolish notions of an "education" -- as though any of us were going to read those boring plaques when there were sleeping lions to be almost half-glimpsed if you could find a high enough spot not blocked by a peanut cart. But one child was there for something more. One child was there ... for a dream.
That child was me, and that dream was to leave my awkward human life behind and become king of the monkeys.
Hemera Technologies/AbleStock.com/Getty
To rule them fairly and justly, meting out fecal projectiles only when it is truly deserved ...
Looking back, I now know that was ill-informed and naive of me: The zookeepers probably wouldn't let a chubby 11-year-old sleep over in the monkey cage, and besides, I'm pretty sure the monkeys, if anything, work on a kind of socialist theocracy. But I didn't know that at the time. All I knew was that life was hard, homework was stupid, and nobody makes fun of the monkeys for wearing bright green Hammer pants. There I was, not 10 seconds from jimmying the lock and claiming my rightful place atop the tire swing, when a snotty little voice cried out.
"Mrs. Davis! Robert's trying to break into the monkey cage again!"
Gary Woobarth. A voice like two pieces of Styrofoam rubbing together. A face like somebody punched a pile of mashed potatoes. As Mrs. Davis led me away, he smiled, and sealed his fate.
So clearly I'm going for a loose animal theme to this whole vengeance quest: We've got the Octopus Throne, the suit of caffeinated cow jerky, the Singing-Bird Pistols, the crab-like claws of the navigation helmet, and the ... dragon-like ... flames of ... all right, fine: The flame gloves don't really fit in here. But they're friggin' flame gloves! They don't have to fit the theme; they shoot fireballs from your palms. Bitchin' palm-fireballs supersede all prerequisites.
"Oh, I need to have taken ECO301 to take this course? Well, I think you'll find that PALM FIREBALLS."
Anyway, to vengeance!
The first step in my cunning plan was to allow Gary Woobarth to have a very successful personal and professional life. This turned out not to be a problem, as Gary was a talented real estate agent and, according to my thousands of reconnaissance photos, hung like an aboriginal fertility statue. Seriously, there's "well-endowed," and then there's "Holy shit, I think your dick swallowed a baguette." Gary definitely fell on the "engorged snake" end of the Dong Scale. The combination of these two factors meant that Gary Woobarth had a wonderful home, a successful career, a beautiful wife, and plenty to lose when I rang his doorbell and left a mysterious box on his front porch. He opened it to find a small plastic monkey, a cellphone, and what looked like gynecological equipment hot-glued to a bike helmet. He barely had time to ponder the significance of the objects when the phone rang.
"Woobarth speaking," Gary answered, like a dickhead.
"You answer the phone like a dickhead," I observed astutely.
"Excuse me?"
"Put the helmet on," I rasped.
"I ... will not do that," he answered. Clever girl.
Kajimoto Laboratories via Treehugger
How did he deduce this was a trap?!
Luckily I was prepared.
"There is a high-powered rifle trained on your heart right now, Mr. Woobarth," I answered, as the laser pointer that I bought at PetSmart lit up his salmon-colored polo.
"What? Who is this?"
"Do you think I'm bluffing? Look down at your chest, tell me what you see."
"A sweet shirt, some sick pecs, and a laser in the shape of a cartoon mouse."
"That's right. That's the sight of a Browning A-bolt .300, and it's trained on ..."
"Why's it shaped like a mouse?"
"I'm ... I'm going for an animal theme here. Just shut up and put on the fucking helmet!"
He did, and much to my chagrin, actually looked pretty good in a helmet covered in specula.
Kajimoto Laboratories via Treehugger
It's a surprisingly fashionable look.
"Tell me what this is about!" he said, the first hint of worry finally creeping into his voice.
"This is a special helmet, Gary. It is comprised of the most cutting-edge technology money can buy. It will guide you upon a route of my choosing. It will do so by administering pain. Follow the pain, Gary, for you are Dante, and I am your Virgil. Enter the inferno!"
"Ow!" Gary answered, "this thing pulled on my ear."
Gary opened his front door and stepped outside.
"Ow," he muttered, swiveled on his heel, and obediently turned left. Gary took six paces, followed another agonizing ear pull, and arrived at the storage shed in his own backyard.
"Hi," Gary said to me, having at last survived his pilgrimage of pain and arrived at the ... Mecca of ... Worse Pain?
"Hi," I answered reflexively, then corrected myself: "I mean Greetings, fool. Welcome to your inevitable karmic destiny."
"I think this is my Tuff Shed, actually," Gary said, looking around.
"No!" I screeched, "These are the scales of justice!"
I turned to swivel my Octopus Throne to face him, but found that it lacked swiveling capability. Really? I mean, really? Jesus Christ. Who manufactures a sinister Octopus Throne without the ability to swivel dramatically? I swear to God, there's just no sense of theater in Evil Furniture Makers these days.
Maximo Riera
Like, why even Evil Apprentice at the Evil Furniture Workshop if you're going to half-ass it like this?
Unfazed, I scooted and dragged the throne around to face my worthy opponent. It took three entire minutes, and one of the tentacles got jammed up in the lawnmower, so I ended up mostly facing the wall.
"This is the sepulcher of your fate!" I finally finished, taking my feet.
"Nah, this is definitely my garden shed. That's my Nordic Gym," Gary said, pointing.
"The Nordic Gym of your regret!"
"Ha, yeah. Tell me about it. I used that thing like once. Four hundred bucks, man! Right in the toilet."
"Sh-shut up, Gary! You're ruining our whole showdown." Sunlight streaming from the open doorway illuminated my face. It reflected off the silver packaging of my Jerkman Suit. Recognition hit Gary like a freight tr-
"Who are you?" Gary asked, squinting into the dazzling brilliance of my energetic meat cloak.
Perky Jerky
Literally the only time the terms "dazzling" and "brilliance" will ever be used to refer to dried caffeinated meat.
"Vengeance," I whispered, "and also Robert."
"Bobby? From Mrs. Davis' class? Hey man, how you been?" Gary's voice took on a sickening tone of easy acquaintance.
"FURIOUS! Do you think I've forgotten your transgressions, Gary? Do you think I've forgotten what you did that fateful day? Do you think I've forgotten the kingdom you robbed me of?!"
"What are you talking about?" Perhaps it was the overpowering stench of berry-and-pepper-infused jerked meat, or the hundreds of reconnaissance photos of his naked waist tacked up around the storage shed, but the seriousness of the situation was finally dawning on Gary. "Are you still on the monkey thing? I told you, man, monkeys work on a form of social theocracy -- without divine blessing, they would have torn you apart!"
"Then it would have been a glorious death! A death of my choosing! And now, I shall give you the opportunity you denied me! Gary Woobarth: Choose your demise."
I gestured to a low table, upon which sat a broken Xbox, a large Tupperware container full of dusty Christmas decorations, a pair of Singing-Bird Pistols in a fine rosewood box, and some bitchin' flamethrower gloves.
The illusion of choice was really just a formality. The correct answer to every challenge in life is always "bitchin' flamethrower gloves."
"Are those bitchin' flamethrower gloves?" He asked.
"Well hell yeah!" I answered. "Awesome, right?"
"Word! But what's the range on those things? Like three feet?"
"Generously," I responded.
"And those are pistols?" He said, pointing to the baroque instruments of beauteous murder.
"Yep. 19th century Swiss Singing-Bird Pistols. Animal theme, remember? The zoo stuff and all."
"Sure, sure. So standard dueling rules, right? I choose my weapon, and you take the one I don't use?"
"Of course! I'm not a savage. Rules are rules."
"OK, well, obviously I choose the pistols. Seriously, dude, flamethrower gloves are bitchin' and all, but they're going to lose to guns every time."
Poor Gary. Always lacking in imagination. It was his only weakness. Well, that and his flammable skin.
I sincerely hope the bird's gentle song lulls you to sleep in hell, Gary.
"Very well," I responded, slipping my hands into the silky embrace of Lady Flamethrowerglove. "Don your armor."
Gary glanced warily at the pile of dusty meat packages resting in his broken wheelbarrow.
"Is that caffeinated meat? Is that what smells like pina coladas and feet?"
"Do I have to?" Gary whined.
"It is ceremonial. You know the rules," I answered solemnly, the crisp hum of my hip-mounted fuel pumps kicking on.
"God, fine. Let's get this over with," Gary humped the bulk of the energy-beef tuxedo over his fine and muscled frame. He hefted his enormous dong out of the way, and grasped both dueling pistols. "Let's do this."
We exited to the lawn, stood back to back, and took our 10 paces -- which was roughly nine paces more than my bitchin' flamethrower gloves would reach. I knew my cause was just. I knew my anger would carry me through. But still, a sick mass of nerves snaked around my guts. I took what might be my last breath on this Earth. The air was cool and clear. The sun was just barely rising beyond the trees. It was a beautiful dawn.
I turned, and heard birdsong.
"What the fuck?!" Gary screamed, staring down at the merrily dancing robot canary that sprouted from the barrel of his pistol. "These aren't real guns! They're just fucking chirping bird toys!"
I smiled, and advanced upon him, flamethrower gloves spewing sultry licks of fire. I greeted the stench of burned flesh, pina coladas, and feet like an old lover.
Buy Robert's stunning, transcendental, orgasmic science fiction novel, Rx: A Tale of Electronegativity, right here. Or buy Robert's other (pretty OK) book, Everything Is Going to Kill Everybody: The Terrifyingly Real Ways the World Wants You Dead. Follow him on Tumblr, Twitter, and Facebook.


text:
Best Booths Winners
Submitted by World Dairy Expo on Wed, 10/05/2011 - 10:04
Hoard's Dairyman:
Best Booth Winners
Date:Wed, 10/05/2011
Hoard's Dairyman hosted the commercial exhibitor party on Tuesday evening. All trade show exhibitors were invited to attend an evening of food, beverages, ice cream sundaes, and great camaraderie. The trade show booth winners were also announced:
Small booth: Trans Ova
Medium booth: Elanco
Large Booth: DeLaval
Return to Hoard's at Expo blog
Return to Hoard's at Expo homepage


text:
The pair were spotted returning to Los Angeles from French Polynesia on Sunday after spending a week there.
Dressed comfortably in a loose black top, a gray cardigan and a white patterned scarf, Kunis – with her ever-growing baby bump – hopped off an Air Tahiti flight with her fiancé, who donned his signature white Cubs hat, according to a post on Instagram.
As reported on several social media posts, the couple were spotted by locals on the island of Taha'a and even stopped to sign autographs for fans.
After touching down in L.A., Kutcher, 36, and Kunis, 30, visited her parents' home.
The trip was a much-needed break in the couple's busy preparation for their new life as parents to a daughter. In May, they purchased a private three-bedroom home in Beverly Hills.
"They are looking for more security now that they have a baby on the way," a source close to Kutcher told PEOPLE. "They're in the nesting phase."


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Criminal Justice Association Bake Sale
- When:
- Location:
- Gordon Plaza
- Description:
Brownies and chocolate chip cookies will be for sale. Take a break to grab a snack and support the CJA. Look for us on Gordon Plaza on Tuesday, May 7, 2013, from 12-2PM.
- Contact Name:
- Maria Renshaw
- Contact Email:
- email@example.com


text:
TURLOCK, Calif. (AP) — Prosecutors say two poultry farmers accused of leaving 50,000 hens to starve are facing felony animal cruelty charges.
Andy Cheung and Lien Diep were arraigned Monday on the charges in Stanislaus County Superior Court.
If convicted, they could face up to three years in prison and $20,000 in fines.
Animal welfare workers who found the abandoned hens at A&L Poultry near Turlock a year ago said the birds had not been fed for two weeks. More than 20,000 were dead and 25,000 were euthanized.
Defense attorney Martha Jane Carlton-Magana said no pleas were entered because one of the defendants faced a family emergency. Pleas are expected March 11.
The lawyer said the men had been working to properly euthanize the birds and had given the flock to a third party.


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Who are the Boston bombing suspects?
POSTED: 02:45 PM PDT Apr 18, 2013 UPDATED: 07:49 PM PDT Apr 19, 2013
As the manhunt for Boston Marathon bombing suspect Dzhokhar Tsarnaev ends, learn more about him and his brother, Tamerlan.
The views expressed are not those of this company or its affiliated companies. Please note by clicking on "Post" you acknowledge that you have read the Terms Of Service and the comment you are posting is in compliance with such terms.blog comments powered by Disqus


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As Immunotherapy Revolutionizes the Cancer Treatment...
LC-MS Gains Favor Due To the...
Developers of DTC Genetic Testing Are...
Wall Street Decline Takes Its Toll...
One of the most time-consuming bottlenecks in molecular biology experiments is efficient grinding, homogenization, and lysis of starting materials. This is especially important in plant research, soil, and environmental sciences, as well as for more common biomedical research areas, including extraction of DNA, RNA, and proteins from microbiological and solid tissue samples. For example, it is estimated, that in plant biology up to 20% of a lab technician's time is spent on sample lysis.
Regardless of the nature of the research, it is essential that samples are lysed quantitatively. Equally important is that the simultaneously released macromolecules are functional and unaltered. In order to preserve fragile structures, it is often necessary to perform lysis and homogenization rapidly and at lower temperatures.
Most researchers today are using chemical, enzymatic, or low-tech mechanical sample homogenization methods. Problems surrounding these methods include inconsistent results due to operator and sample variability, the low-throughput bottleneck of a single sample-processing operation, and long processing times for hard, solid materials like plant tissues or bones.
The most common sample lysis method is grinding samples with a mortar and pestle, either at room temperature or cryogenically using liquid nitrogen. A mortar and pestle is largely unsuitable for low yield molecules and for ultrasensitive downstream detection techniques because it is virtually impossible to assure the absence of sample-to-sample cross contamination.
Other popular methods of sample preparation include ultrasonication, wherein the propagating ultrasound waves shear samples, and handheld, rotor/stator type homogenizers, both of which are limited to soft or suspended samples.
In addition to classical mechanical processes, chemical and enzymatic digestion or lysis are mainly used for cell culture and soft tissue. Examples include proteinase K or Zymolyase enzymatic lysis of mammalian tissue and yeast, however the process is time consuming, often up to 24 hours, and requires incubation at elevated temperatures. Problems arise if the molecules of interest are thermally unstable, prone to enzymatic degradation, or they are present in low abundance.
Mechanical sample lysis can be achieved in multiple ways, however, the nature of the forces acting on the sample can be one of three: cascade impaction, shearing via shear forces, and shearing by fluid vortexing. In cascade impaction, which is essentially the "hammering" of a sample with another object, the direct impact of compression induces cracks and breaking up of the sample. An example is bead beating, where the samples are exposed to the simultaneous impaction of high-density inert ceramic or metallic beads.
Shear forces work by imposing slicing motions on a sample to shred it apart, and can be applied mechanically like with safety razors or by fluid mechanics like the shear flow in a French press or in vortexer. Due to the complexity of 3-D random motion and complex velocity fields in a vortexer, the vortexing process, although strictly speaking is part of shearing, is also considered a separate milling process.
Miodrag Micic, Ph.D., Sc.D., is vp of research and development, and Jeffrey D. Whyte ([email protected]), is global product manager, molecular biology, at MP Biomedicals. Web: www.mpbio.com.
Miodrag Micic, Ph.D., Sc.D., is vp of research and development, and Jeffrey D. Whyte ([email protected]), is global product manager, molecular biology, at MP Biomedicals. Web: www.mpbio.com.
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text:
Three sought in reported Erie home-invasion robbery
Erie police are looking for three men who are accused of forcing their way into an eastside residence and robbing a man on Wednesday night.
Police said the robbery happened at about 8:10 p.m. Wednesday in the 1800 block of Buffalo Road. The victim told police that three males forced their way into the residence and demanded his money. Two of the suspects were carrying handguns. The man gave the robbers money and they left on foot, police said.


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Top Definition
When a straight man has a "crush" on another man, not sexual but kind of idolizing him.
Many straight men end up having man crushes on Johnny Depp (I don't blame them).
додав Na 29 Березня 2004
An admiration for someone of the sex to whom one is not attracted. A man crush is not male specific and encompasses the platonic love one girl may have for another, sometimes termed a girl crush.
I have a man crush on Greg Maddux because he is both a great pitcher and a great man.
She has a man crush on Ellen Page because of Page's quirky sense of humor.
She has a man crush on Ellen Page because of Page's quirky sense of humor.
додав Sole Stealer 18 Лютого 2009
the non-erotic, near-romantic feelings a gay man has for a woman.
When I saw Angelina Jolie in in "Wanted," I felt infatuated. I didn't want to date her, but it was a total man crush.
додав Justin the Bartender 07 Лютого 2011
A straight guy that has an infatuation with a male celebrity. Usually expresses this by posting many pictures of said celebrity on his myspace, facebook, etc.
Mason has a mancrush on Tebow! He has pictures of him ALL OVER his myspace.
додав shhhhh (: 14 Серпня 2010
When a man in a certain case exerts all his manliness into a crush on a woman that he likes. In turn Man Crush
Coady has a huge man crush on Amber-Lynn
додав coadylovesamber 03 Березня 2011
noun. an intense and usually passing infatuation from one man projected onto another;also : the object of infatuation
When a male admires a male and thinks of him fondly.< i.e. a Man to have a crush on some other man>
додав Anonymous 16 Жовтня 2003
the feelings bi-sexual and gay men have for another man. straight men don't have man crushes. the closest thing that might even come close is admiration and respect, but there is no sexual attraction as indicated by the phrase man crush.
hey, where is that cute asian (male) bartender?
oh, you mean the one you have a man crush on?
oh, you mean the one you have a man crush on?
додав xantrani 25 Липня 2009
The goalie of Mario and the Koopas in Mario Strikerz, deified as the eternal Mancrush. Based on the utter mancrushes that players have on him and the inevitable accompanying pre-game ritual.
Great save Mancrush, we would be nothing without your greatness.
додав mere mortal 21 Вересня 2006


text:
LC-MS Gains Favor Due To the...
NSCLC is "Major Battlefield" as Merck,...
Developers of DTC Genetic Testing Are...
Expanding Use of NGS Has Largely...
Recombinant protein expression is a time-consuming task because it requires the combination of a large number of variables that can often subvert timely development. Highly developed bacterial expression platforms are particularly suited to overcoming many of these obstacles because of the rapid growth rates of these organisms and the large number of expression tools that have been developed to meet expression challenges.
However, because primary amino acid sequences of large proteins reveal little information on how best to express a given protein, deciding which tools or combinations of tools will be effective to produce a particular target protein is often elusive. In particular, the expression of secreted proteins with multiple disulfide bonds can be challenging in a microbial system.
What has been needed is a way to apply parallel processing to expression strain development so that multiple expression strategies can be accessed and tested simultaneously. Pfenex has created a comprehensive Pseudomonas fluorescens-based protein production platform consisting of a broad spectrum of effective expression tools that can be seamlessly accessed and integrated to yield an expression strain producing large amounts of functional protein.
Replacing the traditional, linear, and iterative approach to strain development with a high-throughput, parallel-processing model enables construction and evaluation of 1,000 unique expression strains combining novel gene-expression strategies and host cell phenotypes in about one month's time.
The toolbox pyramid diagram contained in Figure 1 describes the expression strategies and engineered hosts available through the platform that are used to generate thousands of completely unique expression strains. These tools can be seamlessly accessed so that any expression scenario can be combined with any engineered host by 96-well electroporation. Both the expression plasmids combining the expression strategies listed in Figure 1 and the competent host strains are off-the-shelf items.
The expression plasmids themselves all employ the same cloning strategy, utilizing optimized synthetic gene fragments to streamline target gene cloning. It is difficult to predict exactly which combination of secretion leader and ribosome binding site (RBS) will work best for the heavy chain (HC) and light chain (LC) of various Fabs.
In fact, we have observed that with each Fab expressed, the optimal strain selected for each Fab is composed of different expression strategy/host strain combinations. A number of monocistronic and bicistronic constructs is screened for any given Fab, which is facilitated by the rapid cloning vectors illustrated in Figure 2.
Synthetic fragments designed with HC and LC coding regions, as illustrated in the figure, are cloned into any number of rapid cloning vectors, which are then electroporated into an array of host strains. These hosts may have one or more protease genes deleted and/or may overexpress folding modulators (chaperones, disulfide isomerases), which enable production of high levels of intact, assembled, functional Fab.
The ability to perform all aspects of strain engineering in an automated, high-throughput, 96-well format is key to this combinatorial approach. An obligate aerobe, P. fluorescens, is uniquely suited to growth by simply shaking in a 96-well plate (0.5 mL culture volume) without oxygen supplementation, reaching cell densities of 30–50 A600 units, as described in Figure 1.
Diane Retallack ([email protected]) is director, molecular biology, and Russell Coleman ([email protected]) is senior scientist, molecular biology at Pfenex.
Diane Retallack ([email protected]) is director, molecular biology, and Russell Coleman ([email protected]) is senior scientist, molecular biology at Pfenex.
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text:
Closed Captioned
A perfect fit is within your reach! Join instructor Kathleen Cheetham as she teaches you the techniques and tricks to fit any garment across the shoulders, neck and back. You'll learn how perfect shoulder fit improves the all-over look of a garment, how to take patterns in and let them out for a smooth fit across the back, and adjustments for asymmetrical bodies. Five pages of practice patterns and a measurement worksheet are included.
Meet Kathleen and get started on a journey to better fit. She discusses essential measurements and the importance of a test garment.
Learn how to diagnose all your fitting problems, from stretching seams to gapping waists.
Securing the facings, changing the length and choosing the correct size lines will save time and improve accuracy when you start making adjustments.
Discover ways to adjust standard patterns for broad, narrow, square, sloped and asymmetrical shoulders.
Princess-seamed garments require a different set of shoulder adjustments to achieve the correct fit.
Simple adjustments can improve the fit across a rounded or asymmetrical back. Learn how to adjust your pattern to add shaping with pivots and darts.
Learn how to add shaping to fix a gapping neckline and accommodate the curves of swaybacks and forward-thrust shoulders.
Fine-tune your neckline, even in ready-to-wear! Kathleen shows you how to add a yoke to your design to accommodate the new darts in an attractive way.
"This is the best class I have taken on Craftsy! I have never been able to make or buy shirts to fit my shoulders. I now feel very confident about making the adjustments needed and I can't wait to get started. Kathleen is a wonderful teacher. I enjoyed listening to her and she made everything so clear and easy to follow. Thanks Kathleen! I can't wait to take more of your classes."
- rmtv2003