text:
+ Log in or register to post
Results 11 to 17 of 17
Thread: Hoofchew: Behind the scenes
Thursday, 5th March, 2009, 06:45 PM #11
Defender (Lvl 8)
- Join Date
- Oct 2006
- Location
- Ann Arbor, MI
- Posts
- 4,971
- Reviews
- Read 0 Reviews
ø Block covaithe
ø Friend+
My communities:
You're welcome. And don't forget, anyone thinking of DMing, or even experienced DMs looking for someone to bounce ideas off of, the judges are here to help. I, at least, am always happy to discuss potential adventures, and I have far more adventure ideas than I'll ever have time to run myself.My games
Check out Living 4th Edition, a community-run 4e D&D living world open to all. Now open for character and adventure submissions!
- EN World
- has no influence
- on advertisings
- that are displayed by
- Google Adsense
Friday, 6th March, 2009, 01:00 AM #12
Novice (Lvl 1)
- Join Date
- Nov 2008
- Posts
- 212
- Reviews
- Read 0 Reviews
ø Block Dawn Raven
ø Friend+
My communities:
Between this, the fact that I just canceled one of the games I DM (way too much work to do a solo game for someone who isn't motivated or enthusiastic enough about 4e and the setting), and Don's gangs really really make me want to run a short adventure.
By the way, I love the description for Les. "Spiked chain." Hell. yes. XD
Collective Homebrew Setting:
Cabal, Urban Horrorscape
Les Ghentel, Githyanki Warlord lv 1
Friday, 6th March, 2009, 03:13 PM #13
Novice (Lvl 1)
- Join Date
- Oct 2008
- Location
- Valley, NS, Canada
- Posts
- 738
- Reviews
- Read 0 Reviews
ø Block ukingsken
ø Friend+
My communities:
Hey I gotta say Raven no matter how you look at it the spiked chain is a bad ass weapon.
And vaithe this is an excellent thread. I think it would almost be a good idea to encourage any DM to post something about their adventure after they do it. Not necessarily a step by step but even a short blurb about how they handled something they hadn't come across before or that took them a while to figure out, or even something they think could benefit people.
It's just nice to get a look into how other people DM and how they organise (Or don't! Power to us improvisers!) their thoughts.
2+2=4 Fate is certain.
LEB Judge Circa 2009
My ChractersL4W Characters
Vashik One Eye
Verrigath Hazzire (Pending Approval)
LEB Characters
Cleaver d'Deneith
Other Characters
Orim Tyudik
Friday, 6th March, 2009, 11:46 PM #14
Novice (Lvl 1)
- Join Date
- Oct 2008
- Posts
- 197
- Reviews
- Read 0 Reviews
ø Block SeaPainter
ø Friend+
Heck... if it weren't for this thread, I never would have considered DMing a game myself. Thanks!!!
edit: oh, yeah... and the description of Cross was MONEY.
Mini Stat
Cross- Male Tiefling Wizard 1
Passive Perception: 12, Passive Insight: 18
AC:15, Fort:12, Reflex:14, Will:14 -- Speed:6
Fire Resistance/5
HP:25/25, Bloodied:12, Surge Value:6, Surges left:5/8
Action Points: 1, Second Wind: not used
Blood Hunt (+1 vs bloodied foes)
Magic Missle
Scorching Burst
Ghost Sound
Mage Hand
Burning Hands
Infernal Wrath
Flaming Sphere
Monday, 9th March, 2009, 06:21 PM #15
Defender (Lvl 8)
- Join Date
- Oct 2006
- Location
- Ann Arbor, MI
- Posts
- 4,971
- Reviews
- Read 0 Reviews
ø Block covaithe
ø Friend+
My communities:
Thanks, guys.
I suppose while I've got this open I should write something about mapping, like I said I would a few weeks ago.
4e D&D is a very tactical game, and some kind of combat map is a must-have, IMO. It doesn't have to be fancy. For Hoofchew I deliberately used a simple mapping system with no external software or image editing, just to show that you don't have to be a mapping wizard to run a complex fight. The Hoofchew map was fairly detailed, with multiple levels, difficult terrain, obstacles, cover, etc., but the map was really not very much work. And the learning curve for old-school code-block mapping is almost nothing; you can make the map in Notepad and paste it inside [ code ] tags (without the spaces).
On the other end of the spectrum, you can use image editing programs like photoshop or GIMP to compose the map. You store the master copy of the map in your image editor's native project format, with layers and whatnot, and export it as your favorite image format, perhaps PNG or JPG, when you want to make a snapshot for players to see, and upload the picture to somewhere on the internet. It helps if you have your own reliable place to host images; you can put images up on enworld itself, but there's a limit to how much disk space you can use that way.
I did that for a while with GIMP. It takes a lot of initial work to get your map set up properly, but once you do, you can do lots of neat things with it that you can't necessarily do with other methods. Of the mapping methods I've tried, this is the most work, but if you've got mad skillz you can get the best looking results this way.
There are a lot of options between those two extremes. I'll cut to the chase and tell you that I'm currently using maptool from rptools.net. It's not directly intended for PbP, but it's free, has good tutorials and a strong community, and it's easy to find links to lots of free backgrounds, tiles, tokens, and mapping objects made by other people who can actually draw. Which is nice for me, since that's a talent that I entirely lack. If you follow the "My Games" link in my signature and look at the Monster Mash games, you can see some of the recent maps I've done with it.
As for running combats themselves, I think the most important things for a DM in PbP combat are to keep things moving, and to provide a complete, accurate summary of the current situation at fairly regular intervals. Obviously you have to interpret the rules too as you go, but to be honest, minor rules mistakes during combat don't really interfere with The Fun. In fact, over-rules-lawyering in combat, a temptation I often struggle with, can often be quite harmful to The Fun. Keep the action moving, and communicate clearly what the situation is. (A good map helps, of course.)
One of the things I really like about 4e, that means that I have more fun as a DM than I did in 3.5e, is that death isn't that big a deal for PCs. It's not pleasant, but it's not career-ending, either, like it usually was at low levels in 3.5. That means I can take the gloves off and really play the monsters to their full tactical potential, doing my best to win. Of course that only applies to running the encounters; when designing them I still want to make sure the PCs have a good chance of victory most of the time, balancing challenge with fun and the needs of the story.
Next: random observations about DMing in PbP and how it differs from tabletop.
My games
Check out Living 4th Edition, a community-run 4e D&D living world open to all. Now open for character and adventure submissions!
Monday, 9th March, 2009, 11:42 PM #16
Scout (Lvl 6)
- Join Date
- Jan 2002
- Location
- Ponca City, Oklahoma
- Posts
- 2,312
- Reviews
- Read 0 Reviews
ø Block DarwinofMind
ø Friend+
My communities:
I cannot speak enough good about Maptool. I've been using it for my game to much much love.
It can look as nice as stuff produced by GIMP, it's got far less learning curve, and actually helps me remember things like marks and curses and etc.
Alise Nita in Thirteenth Moon OOC
Katrina Hallman in Mutant Apocalypse OOC
美咲 in Clash of Steel OOC
Monday, 9th March, 2009, 11:51 PM #17
Acolyte (Lvl 2)
- Join Date
- Nov 2006
- Location
- Europe.And the pbp boards
- Posts
- 3,296
- Reviews
- Read 0 Reviews
ø Block Atanatotatos
ø Friend+
My communities:
Great advice from covaithe. I'm looking forward to your next article, everyone who wants to be a pbp DM should read this.
Current PBPDM in:
Ata's 4e PPvPP Arena
L4W in:
Koryo of the Tiger's Rest in Voda Vosa's "Path of Enlightment"
Belleros Arkeion in Sparky's "Thorantar"
Thormir Brassbeard in EvolutionKB's "Lost-Eberron-4eStyle"
Anostor Duran in covaithe's "Death's Reach"
In L4W:
Alexander Duran, Proud member of the MMCHadarai Polemarkosin:Phoenix8008's "The Captain's Caper"
"Redblade's Riches"
in:KenHood's "TURTLEDOME!:Battle Bone"
In LEB:
Thusk Tharashk Duran
Come join us in the Shifting Seas and Transitive Isles of Living 4th Edition, amazing adventures and great fun guaranteed!
Then to play community 4e in Eberron join us in LEB too! Give life to your characters and contribute to the living settings!
Please excuse my poor English. It is not my first language.


text:
Vitakraft® VitaNature Natural Rabbit Food
A well-balanced, natural diet for rabbits in all life stages. Vitakraft VitaNature Rabbit Food is a diverse blend of herbs, flowers, greens, berries, vegetables and grains fortified with vitamins and minerals for optimal nutrition.
- Natural antioxidants to support the immune system
- Long strand fiber to maintain healthy digestion
- High ingredient diversity to encourage natural foraging behavior
Timothy Grass Hay, Soybean Hulls, Dehulled Soybean Meal, Flaked Peas, Carob Pods, Dehydrated Carrots, Yeast Culture, Cane Molasses, Wheat Middlings, Dried Calendula Petals, Chopped Timothy Grass Hay, Pine Cones, Ground Flax Seed, Puffed Wheat, Dehydrated Cranberries, Dried Rose Hips, Rolled Oats, Calcium Carbonate, Dehydrated Alfalfa Meal, Heat-Processed Barley, Heat-Processed-Soybeans, Dried Parsley, Dried Chamomile Flowers, Dried Bay Leaves, Dehydrated Leeks, Dehydrated Apple, Ground Wheat, Salt, Magnesium Oxide, Potassium Sulfate, Magnesium Sulfate, Ground Papaya, Choline Chloride, Vitamin A Supplement, Vitamin D3 Supplement, Vitamin E Supplement, Niacin Supplement, Vitamin B12 Supplement, Riboflavin Supplement, d-Calcium Pantothenate, Menadione Sodium Bisulfite Complex, Biotin, Folic Acid, Thiamine Mononitrate, Pyridoxine Hydrochloride, L-Ascorbyl-2-Polyphosphate, Zinc Sulfate, Zinc Methionine Complex, Manganese Methionine Complex, Copper Lysine Complex, Cobalt Glucoheptanate, Ferrous Sulfate, Manganese Sulfate, Copper Sulfate, Ethylenediamine Dihydriodide, Yucca Schidigera Extract, Ground Beets, Dried Dandelion Leaves, Dried Raspberry Leaves, Dried Peppermint Leaves, Sodium Selenite
Guaranteed Analysis:
- Crude Protein (minimum) 14.0%
- Crude Fat (minimum) 2.0%
- Crude Fiber (minimum) 20.0%
- Crude Fiber (maximum) 25.0%
- Moisture (maximum) 14%
- Calcium (minimum) 0.7%
- Phosphorus (minimum) 0.2%
- Vitamin A (minimum) 10,000 IU/kg
- Vitamin D3 (minimum) 1,000 IU/kg
- Vitamin E (minimum) 90 IU/kg
Offer feed freely in a large, heavy bowl. Wash bowl and offer fresh feed daily. Clean, fresh water should be available at all times. Store in a cool dry place away from direct sunlight.
$ 55.99Reg: $ 69.99
$ 7.49
$ 49.99
$ 2.49
$ 10.99
$ 8.79Reg: $ 10.99
$ 15.49 to $ 29.99
$ 9.89 to $ 17.09Reg: $ 10.99 to $ 18.99
$ 11.99
$ 9.99
$ 5.99
$ 10.99

subset: commoncrawl


text:
DES MOINES, IA. — After struggling with the extra man on the road all season, the San Antonio Rampage (7-7-0-1) recorded two power-play goals to beat the Iowa Wild (6-7-0-0), 5-2, tonight at the Wells Fargo Arena in the first-ever meeting between the two clubs.
The win over the Wild, formerly the Houston Aeros, pushes the Rampage back to .500 and snaps a four-game winless streak on the road. The Rampage's road power play, which started the season 0-for-27, cashed in twice on the night (2-for-6) and the club has now recorded a power-play goal in back-to-back road contests (3-for-13).
In the win, only four Rampage players were held off the score sheet, and with the exception of Joey Crabb, every Rampage skater recorded at least one shot on net. The three-goal victory margin was largest of the year for the Rampage and breaks the five-game streak of one-goal games.
Captain Greg Rallo led the way with two goals, one of which came on the power play and the other held as the game-winner, giving him 15 goals in 42 games against the former Aeros franchise. Steve Pinizzotto opened the scoring with a power-play goal in the first period, marking his third goal in his first four games with the Rampage. John Lee and Jon Matsumoto also lit the lamp for San Antonio.
Drew Shore recorded an assist in the win and now has a helper in three-straight games. Defenseman Zach Miskovic was also credited with an assist in his first game back with the club after an injury.
Netminder Jacob Markstrom was stellar for the Silver and Black between the pipes in only his second start with the club this season, stopping 34-of-36 shots to claim his first victory of the year for the Rampage.
During the first of seven Iowa penalties on the night, Colby Robak connected with Miskovic, who lifted the puck from the right circle into traffic at the top of the crease. Pinizzotto was there to tip it in past Wild netminder Darcy Kuemper, giving the Rampage the lead at 8:45 of the first period.
Iowa came back six minutes later, finding the Rampage out of position in their own end. Zack Phillips put it past Markstrom to even the score at one.
With 13 seconds remaining on the clock in the first, Lee picked up the puck from Vincent Trocheck and rocketed it from the high slot to beat Kuemper. The go-ahead goal gave the Rampage a 2-1 lead heading into the first intermission.
The Rampage also struck first in the second period. Jed Ortmeyer gathered the puck in the Rampage zone, flipping it to Shore, who fed it to Rallo. The Rampage captain bolted up the half wall, letting the puck fly at the top of the left circle. His wrister beat Kuemper glove side to widen the lead to two.
The former division rivals traded back-to-back penalties, with Iowa capitalizing on a 4-on-3 chance at 13:08 of the second. Defenseman Jonathan Blum received a pass from Connelly, and one-timed it from the left circle, cutting San Antonio's lead to one.
The Wild had a final chance late in the second as Kris Foucault found himself alone in front of the Rampage net, but Markstrom was ready with the blocker and the Rampage held the 3-2 lead through two periods.
San Antonio came out roaring in the third, with Matsumoto opening the scoring just 1:43 into the final frame off an assist from Jack Combs, his first point of the season.
The remainder of the third mirrored the second period, with 36 penalty minutes registered between the two teams.
In the final minutes of regulation, Rallo lit the lamp for the second time, scoring just nine seconds into a power play to break the game open in favor of the Rampage. His fourth of the season gave the Rampage a 5-2 lead, a hole that Iowa ultimately could not climb out of.
The Rampage went 2-for-6 on the power play, while Iowa was 1-for-10 with the man advantage. San Antonio was outshot for the first time in four games, 36-31.


text:
Meet hot Peterboro lesbian personals at matchmaker personals. Our site has thousands of lesbian, gay women, bisexual, transgender and transsexual members. Looking for a same sex relationships and looking for women seeking women in Peterboro then create a free profile today, it's easy!
PeterboroJoin Now Free!
Peterboro | Peterboro Girls | Peterboro Men | Peterboro Gay
Black Singles | Asian Singles | Latin Dating
Matchmaker is a free Peterboro lesbian personals site for your local area. We have the hottest, attractive and available Peterboro lesbian women on the Internet If you are a single lesbian women in Peterboro and are looking for friendship, casual encounters or a serious relationship, create your free profile today!


text:
THQ has revealed lifetime shipped data for its core franchises, including Warhammer 40k, Saints Row and WWE.
THQ has shipped nearly five million Saints Row games, more than 4.5 million Warhammer 40k games and 4.5 million units of WWE Smackdown versus Raw 2009.
Speaking during an earnings call overnight, transcribed by Seeking Alpha, THQ boss Brian Farrell said that the figures "demonstrate that when we focus, build quality games, market them aggressively and launch them in appropriate windows, we are successful".
Despite the impressive data, Farrell said THQ has "conservatively planned the WWE franchise down slightly" this year, due to the current difficult economic climate.
He said: "On WWE, it's a little more complicated. As you know, we've been doing WWE for almost 10 years and that brand ebbs and flows based on the popularity of stars at any point in time. And it also relates to where we are on the platform cycles. In the past platform cycles, it's taken a year or two longer for the WWE consumer to migrate to the next generation of platforms, and we are in the midst of a pretty nasty recession which we think is hurting the WWE consumer a little more than normal.
"So we've conservatively planned the WWE franchise down slightly this year but certainly if the platform transition happens more quickly, if the brand exhibits more strength, you know, obviously there's some upside to that."


text:
on May 21, 2013 - 12:47 AM
SILVER CREEK – The Village Board is looking for ways to improve the downtown business district.
Mayor Nick Piccolo told the board Monday that he met with representatives of STEL Inc. and with Chautauqua County Legislator George Borrello to discuss the potential renovation of the former school building on Main Street. The mayor said the county has not taken over ownership of the property.
Piccolo said there is an estimate of $4.5 million to demolish the structure. He said that STEL, of Dunkirk, has expressed an interest in constructing apartments in the building. Piccolo said STEL is seeking some funding from Chautauqua County, as well as other funding for the project.
Piccolo said that the school building, vacant since 1979, poses several problems, including a rodent infestation, and asbestos and other contaminants inside it.
Trustee Warren Kelly said he set up a meeting with the Chautauqua County Industrial Development Agency for May 30 to see if it has any ideas to improve the downtown business district.
Piccolo said he does not have a definite answer about the closing of Petri Baking Products, which is in the business district. Piccolo said that ConAgra, the new owner of the company, has not revealed whether it will remove all the equipment from the plant when the doors are closed. ConAgra had previously announced that it would lay off the workforce and close the business by June. Piccolo said the latest information is that the company has orders to be filled through the end of August and will keep a partial workforce employed until then.
Piccolo encouraged the trustees and other village officials to support the local businesses that remain in the village and to encourage new ideas for the many vacant storefronts.
In other business, Jeff Griewisch was named disaster coordinator for the village. He replaces the late Richard Bartlett. Steve Romanik and Brandon Griewisch were named his assistants.
There was a lengthy discussion on whether to allow private residents to rent the pavilion at the ballpark for events.
A request from a local resident to rent the pavilion was tabled pending further investigation into liability.
The water-line replacement project is continuing. More than 2,000 feet of eight-inch pipe has been installed in the neighborhoods of Pearl, Elm and Hickory streets.
New lines will be installed on Hanover, Seneca and Pearl streets soon.
The third phase of the project is expected to start after June 1 and will include several other neighborhoods, including Babcock and Burgess streets.


text:
Expanding Use of NGS Has Largely...
LC-MS Gains Favor Due To the...
Adapting to Evolving Business Environments Is...
As Immunotherapy Revolutionizes the Cancer Treatment...
Scientists in South Korea have used intravenous injections of human adipose-derived stem cells (hADSCs) both to prevent development of and reverse the symptoms and neuropathology of Alzheimer's disease (AD) in mouse models. The studies, in the Tg2576 mouse model of AD, demonstrated that either intravenous or intracerebral injections of hASCs led to significant improvements in memory and learning, and reduced the numbers of amyloid plaques and Aβ levels in the brain. The benefits were evident for at least four months after treatment.
Prior in vivo studies have demonstrated that transplanted neural stem cells and bone marrow-derived mesenchymal stem cells can help rescue memory deficits in AD mouse models and hold back Aβ deposition, but neither of these stem cell types would be suitable for intravenous administration, according to Seoul National University's Yoo-Hun Suh, Ph.D., and the RNL Bio Stem Cell Technology Institute's Jeong-Chan Ra, Ph.D. Another source of stem cells is the adipose tissue, which yields adipose-derived stem cells, a mesenchymal stem cell type that can differentiate into both mesenchymal and non-mesenchymal lineages. In contrast with other stem cell types, autologous hASCs are not associated with ethical issues, and, based on data from the team's previous research, can be administered intravenously with no concerns about immune rejection or tumorigenesis.
In the first known study of its kind, the Seoul researchers have now shown not only that intravenously administered hASCs can traverse the blood-brain-barrier and engraft in the brain, but that either intravenous or intracerebral hASC therapy results in dramatic cognitive improvements in Alzheimer's disease mice. These benefits were associated with reduced numbers of amyloid plaques and decreased levels of Aβ and amyloid precursor protein C-terminal fragment (APP-CT) through the induction of neprilysin, which hydrolyzes toxic proteins. Critically, when the hASCs were administered intravenously to young AD mice, the treatment completely prevented plaque formation.
Further analyses showed that intravenous and intracerebral administration of the stem cells was associated with increased brain levels of IL-10 and neurotrophic factors, including VEGF and GDNF, which directly suppressed neuronal cell death. In vitro studies indicated that the hASCs themselves produced IL-10, and stimulated additional IL-10 production by microglial cells. And when transplanted directly into the brain, the hASCs induced cell division and neurodifferentiation of endogenous neuroprogenitors in the hippocampus, and stabilized dendrites and synapses.
"We conclude that intracerebrally or intravenously injected hASCs dramatically improved learning and memory ability and decreased neuropathology of Tg2576 mice by diminishing the formation of amyloid plaques, decreasing Aβ and C-terminal levels and upregulating IL-10, VEGF, and elevating endogenous neurogenesis and synaptic and dendritic stability," the authors researchers conclude. "Although it is yet unclear how hASCs upregulated IL-10 and growth factors such as VEGF and GDNF, our findings that intravenously transplanted hASCs prevent the onset and progression of the disease clearly provide an important preclinical platform for the development of prevention and therapy for AD patients."
To save this item to your Favorites,
log into GEN Select.
We'll be sure to take you back here after you do.
Not a member of GEN Select?
To comment on this article,
log into GEN Select.
We'll be sure to take you back here after you do.
Join 110,000 colleagues who rely on GEN Highlights for breaking news and exclusive articles shaping today's life science tools and technologies.
You're all set! Thank you for subscribing to GEN Highlights.
While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country's most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?
Be sure to add [email protected]
to your Address Book or Safe Senders List.
here for instructions.
If you have any questions about your subscription, click
here to email us or call at (914) 740-2189.
You may also be interested in subscribing to the GEN magazine, an indispensable
resource for everyone involved in the business of translating discoveries at the
bench into solutions that fight disease and improve health, agriculture, and the
environment. Subscribe
today to see why over 60,000 biotech professionals read GEN to
keep current in the areas of genomics, proteomics, drug discovery, biomarker discovery,
bioprocessing, molecular diagnostics, collaborations, biotech business trends, and
© 2016 Genetic Engineering & Biotechnology News All Rights Reserved


text:
CD-adapco is the world's largest independent CFD focused provider of engineering simulation software, support and services. We have over 30 years of experience in delivering industrial strength engineering simulation.
April 12, 2013. New York and London
CD-adapco is pleased to announce the availability of the STAR-CCM+ v8.02 Update Release. This second release of STAR-CCM+ v8.02 aims to fix a number of issues reported in the first one.
Please login to the Steve Portal [1] and navigate to File Downloads to obtain the new release.
[1] http://steve.cd-adapco.com/
[2] http://www.cd-adapco.com
[3] mailto:firstname.lastname@example.com


text:
Understanding complex code with Code Map
- Posted: Nov 15, 2012 at 2:57PM
- 20 comments
Loading user information from Channel 9
Something went wrong getting user information from Channel 9
Loading user information from MSDN
Something went wrong getting user information from MSDN
Loading Visual Studio Achievements
Something went wrong getting the Visual Studio Achievements
Right click "Save as…"
This short video introduces Code Map, a new feature for visualizing and navigating complex code without getting lost.
Video available in: Chinese (Simplified) Chinese (Traditional) Czech French German Italian Japanese Korean Polish Portuguese (Brazil) Russian Spanish Turkish
Related MSDN Article: Understanding complex code with Code Map
Oops, something didn't work.
Nice feature, I believe it is available in the VS2012 Update 1 CTP 4?
ps. the MSDN link doesn't work (page not found).
Please, release a patch to address the issues XAML is currently having. Every time I fix one problem, another one arises.
1. I have Visual Studio Ultimate 2012 and the feature is not there.
2. The link to the alleged MSDN article does not work
Hi everyone,
Thanks for all your comments. We have a team working on the broken MSDN link.
To create code maps, you'll also need Visual Studio 2012 Update 1:
@DabizLegend: Could you give more detail on the XAML issue you are referring to?
@EstherFan:I've installed VS 2012 Update 1. However, I cannot see the code map in the menu by right clicking on any member of my C# project. Did I miss something?
Has anyone else noticed that the video references itself as a tutorial introduction? Now I don't want to use this feature because it's just too meta.
Thanks. Its a perfect feature...
A feature where I can draw a block on the designer surface of code map which translates into C# code (Either a method, a variable) will be more interesting and useful.
Firstly: Why doesn't this feature work with C++?!
For crying out loud, stop with this passive aggressiveness already!
If you are not going to support C++ fully than come out and say so already!
You host things like GoingNative while on the other hand your own tools are not able to support C++ fully.
Secondly: You need an entire team to fix one single broken link that should not have been broken to begin with ?!
I'm guessing you are using Azure or some other microsoft cloud product?
Been having lots of problems with MSDN lately. Takes ages for it to load. It was slow before but now it is even worse! Like Vista and W8 style!
I find it strange that i now 4 days later after the release, gets notified of the release from vs2012 updater.
Please don't tell me you use racial country release time tables.
Like united states gets it first and the rest of the world gets it a few days later.
Can any other people (not living in unite states) confirm this?
Wouldn't be the first time.
Yes i will complain until the country racism gets removed. Geo-blocking is racism too btw.
No, it is douchebaggery but mostly incompetence.
Consider if a person would refer to itself like that. That would earn that person an a-hole stamp.
This seems very interesting indeed. Excellent work and major kudos to the people who developed this. I think it'd be extremely helpful (At least as an option) to mark in a different color or otherwise emphasize the arrows from method to fields, where the method *writes* to the field (Rather than just read from it).
@EstherFan:I've installed VS 2012 Update 1. However, I cannot see the code map in the menu by right clicking on any member of my C++ project. Did I miss something too?
@vivihung: Which version of Visual Studio 2012 did you install? Professional, Premium, or Ultimate? The feature is only supported on Ultimate
I can't believe this feature isn't supported for C/C++. Un-be-lievable!
Good grief, why not?!
It is a shame this is only available in ultimate. This feature would be worth paying for as a plugin for visual studio professional. Have you ever thought of having an app store for development tool extensions within Visual Studio?
@Klasik: C++ is currently not supported
It is a shame this is only available in ultimate. This feature would be worth paying for as a plugin for visual studio professional. Have you ever thought of having an app store for development tool extensions within Visual Studio?
^ This
Very nice and elegant way to solve a problem.
please, Can you share the project itself for a better understanding ?
thank you in advance.
While C++ lacks the metadata structures that C# 'inherits' from the CLR I do think you could do a better job at visualising C++ code in VS2012 than is currently the case. There are tools that build upon Clang this area that show that given an AST a great deal of insight can be gained and decent visuals rendered.
I think this is a great feature to understand unfamiliar code and to communicate code structure across a team.
Comments have been closed since this content was published more than 30 days ago, but if you'd like to continue the conversation, please create a new thread in our Forums, or Contact Us and let us know.


text:
on December 8, 2012 - 11:21 PM
NIAGARA FALLS – Nominations of individuals and organizations for awards that exemplify the ideals of the late Rev. Dr. Martin Luther King Jr. are being reviewed by committees in preparation for the city School District's annual Martin Luther King celebration scheduled for Jan. 17.
Nominations, which already have been submitted by members of the community, are being reviewed by invited individuals and by the standing Rev. Dr. Martin Luther King Jr. Celebration Committee, according to Judie Gregory-Glaser, community relations director for the Niagara Falls schools. In addition, nominations for the city's High School Youth Civil Rights Achievement Award will be reviewed by the High School Student Council for a final decision.
Gregory-Glaser said three awards will be presented during the Jan. 17 program: a Civil Rights Achievement Award and a Spirit of Dr. King Award, in addition to the Youth Civil Rights Achievement Award.
Candidates for the Spirit of Dr. King Award must perform their work in an unpaid capacity and set an example consistent with that of Dr. King in personal conduct, volunteer work, charitable efforts or promoting the dignity of others.Candidates for the Youth Award must be current students enrolled at Niagara Falls High School.
email: firstname.lastname@example.com


text:
Baby Games
Cooking Games
Dress up Games
Fashion Games
Fun Games
Girl Games
Hair Games
Pony Games
Flip or Flop
Elsa Real Cooking
Dora Forest Drive
Anna Real Cooking
Hairdressing Girl
Fruit Salad Day
Dora Playtime with the Twins
Build Yourself
Ice Cream Craze 3
My New Hair
Baby Sitting
Tea Restaurant
Potato Peel
Dora Fairytale Fiesta
Bunny Ice Cream Maker
Pizza Making
Strawberry Cake Decoration
Santa Coloring Book
Elsa Frozen Baby Feeding
Frozen Baby Bath
Angelas Baby Wash
Cooking Academy
Dora Bike Adventure
Elsa Baby Wash
3D Haircut
Rapunzel Baby Feeding
Bingo with Dora
Dora Ballet Dress Up
Sandwich Cooking
Papa Cupcakeria
3D Fashion Model
Dora Riding Bike
Snow White Baby Wash
Snow White Baby Feeding
Baby Bottle Feeding
Dora Saves Map
Dora Magical Garden
Quiet Cooking
Papa Burgeria
Dora Pony Dress Up
Bratz Babyz Mall Crawl
Burger Shop 2
Dora Saves The Farm
Super Hair Studio
Yellow Bus Kiss
Sofia the First Dress Up
Ice Cream Serving Master
Smurfette Cake
Cute Pet Hospital
Happy hairdresser 3
Dora Train Express
Bakery House
Papa Taco Mia
Cake of Fun
Restaurant Love
Papas Wingeria
Babies Clinic
Dora Matching
Sofys Baby Shoppe
Dora Pet Shop
Dora Moroccan Chicken Recipe
Papa Freezeria
Hot Dog Serving Master
Lovely Bunnies
Games for Girls
All games and descriptions copyright © to their respective owners. All rights reserved. There are 2627 games played today | There are 8 users online.
Privacy Policy
Terms of Use


text:
Top Definition
the phrase said by a stoner before passing teh pips
"eer you go bro" --couch couch gag wheez--
автор: my name is already bieng used 11 октября 2008
Trending Now
Can you define these popular missing words?
a pot heads favorite word
автор: trevor 9 марта 2003
to attract ones attention by shouting 'eer'
eer mate can i hav some cowies
автор: dave 28 апреля 2003
A high pitched screeching sound used in substitute of the word awesome.
Man that is like EER!
автор: Christian 10 апреля 2003
"EVERYTHING ELSE REQUIRED" - It's kind of a term used after we finish a chat... people hate to type "good bye... c ya... sweet dreams..." and on and on... "EER" instead... you an start with "good bye... cya... and EER..." and as time moves on and people get familiar with the term, you can just use "EER" to bid farewell, when you think it's time to leave... or whatever...
Oops... sorry, I've got to go to school... so, EER :)
автор: shyams14th 22 апреля 2011
To act in a manner that produces eerie feelings from others.
Kirk got quiet, producing an eerie feeling from Scotty. "Man...I hate it when she eers like that."
автор: Kirk'n'Scotty 22 июня 2005


text:
Martinsburg VA staff carry on tradition of excellence
January 13, 2013
MARTINSBURG — In an auditorium filled with doctors, nurses, families and guests, the West Virginia Center for Nursing recognized five Martinsburg VA Medical Center (VAMC) staff members with the 2012......
I was admitted to the VA with chest pains last year. It was the worst experience I have had from any hospital to date. They use this type of propaganda to cover up the real Martinsburg VA. stories. I was told wrong information, treated disrespectfully and had to check myself out from fear of being infected with MRSA by the male nurse. Under paid, under staffed and under trained is the truth. Management would rather lie about the status than confront the reality of the situation. I am a disabled vet. who is embarrassed by this VA management, the problem is from the TOP down from what I gather from the staff. Its more of a who you kiss up to rather than who does the best job. Over time the good workers get discouraged and all that is left is a bunch of*****ups. The VA management encourages the behavior with unearned bonuses and special projects that they handout to their special friends. It is sickening to watch as it happens everyday.
0 Agrees | 0 Disagrees | Report Abuse »
Showing 1 of 1 comments


text:
The region's lawmakers are painfully aware that the "fiscal cliff" looms, and like much of the rest of the nation are hoping some resolution to the U.S. government's overwhelming $16 trillion debt is found.
Not surprisingly, U.S. Reps. Glenn "GT" Thompson, R-Howard, and Thomas A. Marino, R-Cogan Station, appear to be on the same page as the rest of their conservative brethren in Congress about ways to resolve the crisis.
"I think we are closer than what we were," Thompson said at mid-week.
Article Photos
The lawmaker said as far as he's concerned, everything should be on the table with regard to spending cuts.
In other words, there are no sacred cows, including possible cuts to defense.
"I want our military to be the mightiest fighting force on the Earth, but I know there are areas of wasteful spending we can cut," he said.
Marino said it comes down to the simple approach of cutting spending and reforming the current tax code.
Marino and Thompson both signed the Grover Norquist Tax Protection Pledge guaranteeing they would oppose tax increases.
Are they both willing to give a little on that promise?
"No. Not at this point," said Thompson. "I didn't sign it to keep from raising taxes, but to show that raising taxes doesn't solve the problem. The federal government has an addiction to spending."
Marino said he signed the pledge two years ago.
"I signed nothing that said I will not do it forever," he said. (But) Before I do that, the Democrats have to be willing to make cuts."
Without spending cuts, the fiscal crisis will never be resolved, he said.
Thompson and Marino represent just two votes from among
435 members of a mostly Republican House.
During the past two years, GOP House members have not been on the same page with President Obama and Senate Democrats.
Is there any reason to believe that will change or will Congress find a way to reach a compromise to avoid the "fiscal cliff?"
"My guess is there is a lot more substance going on behind closed doors," said Dr. Jonathan Williamson, assistant professor of political science at Lycoming College and chairman of the school's Political Science Department. "Whether it's productive or not is hard to know. We had a status quo election. It's the same two sides squaring off against each other."
Williamson said there seems to be some indication that each side will give ground.
Marino said he thought the two sides are not getting closer to a compromise, but that's no reason to give up.
"It's a process. What I have found in my four years in office is that big things (in Congress) are last-minute resolutions," Thompson said. "That's the track we are on now. We will be in here the week leading up to Christmas. We know we have over a $16 trillion debt. That is something accumulated by presidents of both parties and by past Congresses. We can't do it by just cutting spending. We will also take measures to raise revenue."
Thompson said those additional revenues can be found through simplifying the tax code and eliminating the loopholes.
Marino agreed, but said it would have to be done over time.
"We have to eliminate the tax code as we know it and introduce a flat tax," he said.
Thompson said he's against raising taxes on the wealthiest Americans.
Many people who earn more than $250,000, he noted, are small business owners who would be forced to lay off workers.
As for the nation's biggest wage earners, many of them have the best tax attorneys who can help them shield their earnings from taxes.
"I would project most of those people would never pay another extra dollar of taxes," he said. "We have an overly-complex tax code. Let's simplify the tax code. We could do that and lower marginal rates. That could stimulate the economy."
The middle class, particularly those looking forward to collecting Medicare and Social Security, are paying close attention to what is transpiring in Washington this month.
Take Medicare.
Thompson said he'd consider raising the age by two years to 67 for when people could go on Medicare, but with some provisions.
"The reality is that we are living a lot longer. Most people statistically aren't retiring at age 65," he said.
Nothing should change for people already on Medicare, Thompson added.
The reality, he said, is that Medicare, along with Medicaid and Social Security, comprise some 60 percent of the federal budget.
Medicare, for example, is expected to pay out more in benefits than it pays by the year 2023.
"That is a path to insolvency," he said. "We either deal with those issues now or put our head in the sand like the president," he said.
Marino said raising the age for Medicare poses lots of questions.
"It's something I'm still looking at," he said.
He suggested that the Medicare age could be adjusted depending on one's occupation.
For example, laborers in physically demanding jobs, are perhaps ready to retire earlier than a white -collar person with a desk job, he said.
Such questions are at the crux of the debate between the two sides deciding the fiscal crisis.
"We want more in America, but are we willing to pay for it?" asked Williamson.
Marino said the federal government simply has a spending problem.
He went as far as accusing Democrats in Congress of having a kind of death wish.
"Democrats want to go off the 'fiscal cliff.' It's a plan to place blame on House Republicans. It's a way to gain back the House in two years," he said.
That would result in inflation, a lowering of the dollar and rising unemployment, according to Marino.
China would then surpass the U.S. as the world's financial power.
"In all the chaos, China is just sitting back, waiting and waiting," he said.


text:
NBC Sports did a quick write-up about this. They quoted an interview they say Thornton gave "recently". Here's a quote:
He recently spoke out in favor of fighting, while a debate about whether that element should be taken out of the game rages on.
"I don't know the numbers so I probably shouldn't [say] but I think a lot more concussions are happening from head hits than fighting, but any time anyone gets punched in the face and gets hurt, people jump all over it,"he recently told Katie Strang of ESPN.
"I think there's an agenda. I'm not sure where it's coming from. I won't say it's changing the tide, but I think there's definitely more of an agenda nowadays.
"People could probably criticize that I'm a little too honorable, I suppose, in some instances. I've been a firm believer my whole life that what goes around comes around.
"If you're one of those guys that suckers someone when they're down or you go after somebody that doesn't deserve it or isn't the same category as you, that will come back and bite you at some point, too."


text:
on July 9, 2013 - 5:04 PM
A Canadian convicted of armed robbery in California and later deported is facing new charges of illegally reentering the United States.
Elizabeth Reid, 31, was arrested on Busti Avenue in Buffalo last week by U.S. Border patrol agents and charged with illegally entering the country after an aggravated felony conviction.
U.S. Border Patrol Agent Matthew Bitterman said Reid claimed to be a U.S. citizen and gave agents a fake California birth certificate.
Bitterman said she was ordered removed from the country on two prior occasions.


text:
One of the oldest forms of bigotry in existence, anti-Semitism has persisted on account of religious intolerance, cultural misunderstanding and centuries-old myths that have resulted in divisions among cultural and religious groups and, in the most extreme cases, the loss of lives, families and communities. From bigoted jokes and slurs uttered in school halls to physical assaults and the desecration of Jewish synagogues and cemeteries, anti-Semitism manifests in all forms and instills fear in any community. For as long as the U.S. Federal Bureau of Investigation has kept records of national hate crime activity, anti-Semitism has accounted for a majority of the hate crimes motivated by religious bias in the U.S., which is the second highest motivating factor of all hate crimes, the first being racial bias.
Studying anti-Semitism can debunk centuries-old myths that are the basis for many anti-Jewish and anti-Semitic incidents. Learning about the history of the Jewish people and the development of anti-Semitism combats misinformation about Jews, reveals the origins of age-old anti-Jewish stereotypes, and provides factual information that challenges anti-Semitic remarks and intolerance.
There are four lessons included in this unit that establish ground rules for respectful discussion on anti-Semitism (Lesson 1); provide students with a basic understanding of Judaism and the cultural, historical and religious aspects of the U.S. Jewish community (Lesson 2); offer facts to refute anti-Semitic myths and stereotypes so that young people can effectively respond to anti-Semitic incidents in their schools and communities (Lesson 3); and present a brief overview of the history and current day manifestations of anti-Semitism including extremist activity in the U.S. (Lesson 4).
This curricular unit also contains a number of resources for educators, students and families, including a myths and facts booklet on anti-Semitism, a list of book and video resources on anti-Semitism, recommended books on Jewish culture and faith, a handbook on the teaching of religion in public schools, a link to the ADL discussion guide, Anti-Semitism and The Merchant of Venice, and information on a new multimedia curriculum on the Holocaust that includes compelling video of first person testimony from Holocaust survivors, rescuers, and liberators.
In general, the study of anti-Semitism informs us of how all forms of bigotry operate. Prejudice of any kind can ultimately lead to hateful actions such as scapegoating, social exclusion, discrimination, and the genocide of a group of people. Understanding how anti-Semitism grows can help students recognize the importance of standing up to prejudice of any kind before it escalates.


text:
"If you like your health care plan, you'll be able to keep your health care plan, period" is destined to become one of the most important statements ever uttered by a president of the United States.
It's going to be code for big government failure.
Barack Obama made his assertion on June 15, 2009, and he and other Democrats said it or something similar again and again and again and again during their campaign to win public support for their Affordable Care Act.
We know better, now.
The Democrats lied to us about our health care plans and other facets of Obamacare; the Obamacare concept was and is fundamentally and fatally flawed; and politicians with grand schemes are no match for a free market economy.
Obamacare's wrinkles deepen by the day. The website doesn't work. "Navigators" can't navigate. Security is weak to non-existent. Financial projections are collapsing.
And then there's the wart - the health insurance cancellations. Millions and millions of them. People are being kicked off of policies they like and can afford because of
The political fallout is growing, and congressional Democrats know it. Those up for re-election in 2014 see their blood in the water.
The highest-profile Democrat to speak out has been former President Bill Clinton, who desperately wants to become Mr. Hillary Clinton, the First Gentleman, in 2016.
He chides that Obama "should honor the commitment the federal government made and allow people to keep the insurance they have." Note that Clinton didn't say "the commitment Obama made."
Another concerned Democrat is North Carolina Sen. Kay Hagan, who is up for re-election (dare we say "un-election"?) in 2014. She wants congressional investigations and supports a bill put forth by Louisiana Sen. Mary Landrieu, who also is up for re-election ("un-election") in 2014.
Landrieu's bill, "Keeping the Affordable Care Act Promise" (S.1642), tries to put the genie back in the bottle by forcing insurance companies to offer 2013 plans on the individual market indefinitely and to continue offering a number of plans they've already cancelled because of Obamacare.
Sen. Dianne Feinstein of California likes Landrieu's bill, probably because she's received 30,842 calls, e-mails and letters from unhappy constituents.
In announcing her support for the bill, Feinstein said, "We must ensure that in our effort to reform the health care system, we do not allow unintended consequences to go unaddressed." She says Landrieu's bill is "a commonsense fix" and "a simple fix to a complex problem." (It's neither.)
West Virginia's Sen. Joe Manchin, who is not up for re-election next year, is with Landrieu, and he also wants to extend the Obamacare enrollment deadline to Jan. 1, 2015. Two months ago, he supported a one-year delay until he voted against a one-year delay.
Manchin: "We are a consumer nation. We have the great entrepreneurs. We can make this happen, but we've all got to be on the same team right now, and that's Team America to make this happen."
Stop laughing, please.
Obama is his own team, and on Thursday, he broke with worried Democrats by announcing that he, himself, would allow people to keep their current health insurance policies for a year. He can't do that, of course, but his statement was an attempt to scuttle the Landrieu-Hagan-Feinstein-Manchin bill.
Landrieu gave the president the cold shoulder by saying she'll continue pushing her bill.
What will eventually happen to Obamacare? It will have to be put out of its misery, to be replaced by simple laws that target specific problems. We shouldn't have to hand our lives and well-being over to politicians and bureaucrats.
That said, we also shouldn't forget Obamacare. We need to remember it for generations to come, and it should serve as an example of what can happen when we become too reliant on a government that is too big and too powerful.
That, in fact, should be President Obama's legacy.


text:
Serves 8 |
Prep Time 10 minutes |
Cook Time 0 minutes
6 Tbsp Eden Red Wine VinegarEden Apple Cider or Organic Brown Rice Vinegar
2 Tbsp Eden Brown Mustard
5 Tbsp Eden Extra Virgin Olive Oil
1/2 tsp Eden Sea Salt
1/8 tsp freshly ground black pepper, or to taste
1 Tbsp Eden Barley Malt Syrup
2 tsp organic maple syrup
10 ounces mixed baby salad greensor baby spinach
1 cup red onion, thinly sliced into half-rounds
1/2 cup Eden Dried Montmorency Cherries
4 ounces Eden Roasted Pumpkin Seeds, 1 packageEden Spicy Pumpkin Seeds
To make the dressing, combine the vinegar, mustard, olive oil, sea salt, pepper, barley malt and maple syrup in a small bowl or a measuring cup. Mix the dressing with a whisk or fork. Place the spinach or baby salad greens in a salad bowl. Toss in the cherries, red onion and pumpkin seeds. Serve with the dressing on the side.
American, Condiments, Good/High Fiber, Good/High Protein, Macrobiotic, Oils, Salad, Snacks, Sweeteners, Vegan, Vinegars, Wheat-Free


text:
- Flat Rate Shipping. Any Size Order! -
- A Portion of Proceeds Benefit Baltimore Ravens Athletics -
Main Content
Order as many items as you like with our $4.99 flat rate shipping.
This item ships within five business days.
Order as many items as you like with our $4.99 flat rate shipping.
Need it faster?
Help someone celebrate their Baltimore Ravens fandom with this golf gift set from WinCraft! Golfers and Baltimore Ravens fans can be tough to please when it comes to gifts, but this great gift set is sure to make them happy! It includes three balls and one high-quality towel, all emblazoned with Baltimore Ravens graphics to make any fan proud.
- Material: 100% Cotton
- Sports towel
- Decorated in the team colors
- Designed with the team logo
- Officially licensed
- 3 Regulation golf balls
- Machine wash
- Officially licensed
- Imported
- Brand: WinCraft
Ravens Customers also liked:
Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


text:
HUNTINGDON - James Troha, vice president for institutional advancement and university relations at Ohio's Heidelberg University since 2009, has been named the 12th president of Juniata College by the Juniata Board of Trustees.
Troha will begin his official duties on or about June 1.
Troha takes over the presidency from Thomas R. Kepple Jr., who will retire May 31 after serving the college for 15 years as its chief executive.
"Jim Troha has a strong record of proven leadership in numerous aspects of running a College, including student affairs, enrollment, and fundraising," trustees Chairman Robert McDowell said in a written statement. "He is also very community-focused in his personal and professional life, and we expect that focus will benefit Juniata, Huntingdon and the global community, which is so much a focus of our student's educational experience. The board is very pleased to have concluded our search and to have been successful in recruiting our first choice as our new chief executive."
Troha's responsibilities at Heidelberg University in Tiffin, Ohio, include directing all elements of the institution's fundraising, marketing and university relations efforts.
"Juniata has great momentum, and I am enthusiastically looking forward to working with the board, faculty, students, staff and the larger Juniata and Huntingdon community to foster the College's continued success," said Troha, who is married with three children. "Jennifer and I are appreciative and humbled to be asked to be part of the next evolution of Juniata and look forward to our arrival in Huntingdon."
In addition, Troha has significant executive experience, serving as Heidelberg's interim president for a year, from July 2008 to June 2009.
He oversaw several projects including refinancing the university's $17 million in state-issued bonds and leading Heidelberg's transition from a college to a university. As part of that transition, he oversaw the integration of a new marketing program and branding effort.
A native of Cleveland, Ohio, Troha earned a bachelor's degree in criminal justice in 1991 and went on to earn a master's degree in counseling in 1993, both from Edinboro University of Pennsylvania. In 2005, he earned a doctorate in educational policy and leadership from the University of Kansas in Lawrence, Kan.


text:
HOLLIDAYSBURG - After almost six decades of operating Valley View Home, Blair County leaders said Tuesday that they will consider selling the facility, drawing immediate criticism from representatives of the home's 289 employees.
Commissioners voted Tuesday to ask the Chicago real estate investment firm of Marcus & Millichap to calculate the home's potential value, at no cost to the county. It's the first step toward what could lead to advertising for offers on the 240-bed facility.
"It's a consideration and nothing is carved in stone," Commissioner Ted Beam Jr. said. "We're just going to proceed to see what Valley View is worth."
While the home currently carries a debt of $8.98 million, which includes $3.5 million owed to the county for prior payment of employee benefits, Marcus & Millichap Senior Associate Joshua Jandris said he believes the home's value and potential bids will exceed that.
"Nursing homes are extremely valuable assets," Jandris said. "Based on size, occupancy, their revenue, their potential revenue ... I think we will get a price that satisfies that debt."
Commissioners informed union leaders Tuesday morning, before starting their weekly meeting, of the pending vote. Their action generated tears among employees worried about how the sale will affect the care of residents and their jobs.
"Valley View is more than just a business to sell," nurse's aide and Service Employees International Union Healthcare leader Dawn Futrell said.
"We care for the most vulnerable, the sickest of the sick, the poorest of the poor," said Sharon Pope, a certified nursing assistant for 11 years. "What happens to them when it stops being about care and starts being about making money?"
Commissioners Chairman Terry Tomassetti said a lot has changed since 1954 when the county opened Valley View Home to care for elderly and disabled residents.
"We now see here in Blair County a large number of quality private sector skilled nursing facilities available to meet the needs of our residents," Tomassetti said.
Commissioner Diane Meling said the home's financial picture has improved in the last four years, another reason to consider this option.
"When times are good, that's when you make a sale," Meling said, "perhaps one that would lead to improvements at the home."
"We feel slighted," Futrell said. "Year after year, we've hung in there, giving concessions, agreeing to pay freezes ... with the goal of getting the home out of the red. All for this."
SEIU Healthcare representative Matthew Yarnell said he will monitor the commissioners' actions related to the sale and look for information to influence how they vote.
Jandris said commissioners can impose requirements as part of a sale to maintain current care of residents and percentage of beds for Medicaid recipients as well as address employment of current employees.
Yarnell offered doubts about such efforts, based on Cambria County's 2010 sale of Laurel Crest Rehabilitation & Special Care Center, which led to a strike and a lawsuit against the county and Grane Healthcare, which bought the home and refused to recognize the union.


text:
Product Description
Hypercom M4240 Mobile Credit Card Machine
The Hypercom Optimum M4240 Mobile Credit Card Machine is a powerful Bluetooth terminal for ultimate functionality in a compact portable design for virtually any installation. The Optimum M4240 has industry leading features such as 24MB of total memory, an ARM9 processor for fast transactions and multi-application. The Bluetooth enabled Access Point features IP or dial communications and an RS-232 port for the most secure direct pairing and can be mounted anywhere for optimal range and performance.
The Hypercom Optimum M4240 also features an optional charging dock for convenience. Combine that with the M4240's compact design and intuitive interface and it is the perfect solution for short range wireless markets such as Pay-at-the-table or installations where traditional connectivity is costly or prohibitive. Truly designed for maximum performance, the Optimum M4240 features new "Power-Amp" Bluetooth technology, providing the best connectivity over the greatest distance, even through barriers and obstacles that may exist at the merchant location. The reception and range of the Hypercom Optimum M4240 Bluetooth solution is over double that of competitive models.
Product Suggestions
You May Also Like...
Related Products


text:
America's 11th President. Known as "Napoleon of the Stump"
James K Polk made sure sure the tariffs fell, made the English sell the Oregon Teritory, built an independent treasury, and after this he sought no second term
de nj 8 mai 2004
Trending Now
Can you define these popular missing words?
Top Definition
The most badass President in history. When elected, he said that he will only serve one term and promised to make the US a continental power. In four years, Oregon, Washington, California, Arizona, Nevada, Utah, Colorado, Idaho, New Mexico, Texas, and parts of Wyoming were part of the United States. He died three months later. He could kill a man by just staring at him.
Who was the most badass president in US history? James K. Polk!!!
de lostinthesupermarket 19 décembre 2006
11th president of the United Sates; also said to be the first white man to have a Chinese character as a tattoo.
de spunkychick 2 juillet 2011
The bane of Mexicans everywhere.
James K. Polk stole the Rio Grande!
de interesting45 15 mai 2010
Killer, thief, corrupter of traditional values.
James K. Polk's legacy has harmed many, and to an extent has corrupted my country. But what it leads to in the future could be far worse.
de Richard L. Peterson 26 octobre 2007


text:
I am a member of the Fusion Middleware Applications Consultancy team.
I focus on tips and tricks FMW applications consultancy but also have a strong interest in ADF Development & Achitecture, Oracle BPM, Oracle Identity Manager and Oracle SOA Suite.
The views expressed on this blog are my own and do not necessarily reflect the views of Oracle.
Recent Posts
- Deploy Composite Using WLST
- Using Identity Browser Dialog in ADF Page
- Redeployment with Keep Running Instances option
- Tune your JDeveloper 12c (12.1.3)
- Oracle SOA 12c Auto-Purge (New Feature)
- BPEL Calling Web Services with HTTP Basic Authentication
- Oracle Fusion Middleware & PaaS Partner Community Forum 2016
- OSB 12c - "Logged in role is not allowed to view/edit Access Control Policies"
- Schedule OSB Service Using ESS
- Disable "Build After Save at JDeveloper" 12c


text:
Thursday, October 31, 2013
Sewee Outpost announces that owners have completed a brand new 18 hole disc golf course on the grounds around Sewee Outpost. It is the first disc golf course east of the Cooper and will hopefully encourage the growth of this up and coming sport in our area.
The first tournament kicks off at 10 a.m. on Saturday, Nov. 9, followed by a barn jam at Awendaw Green, starting at 4:30 p.m., featuring Ten Toes Up and Sun Dried Vibes. All barn jams are family oriented and kid friendly. The disc golf course will be open for free play after the tournament and all day Sunday, Nov. 10. There is a $5 charge for barn jam entry to any non-players and everyone is welcome.
The tournament entry fee of $25 covers two rounds of singles play, lunch, an Innova disc, and entry into the barn jam. Register at http://www.discgolfunited.com/disc-golf-tournaments/tournament-dashboard.cfm/tourn_id/962
The Innova team came down to Awendaw over a series of visits and designed a top level course. It has a wide variety of thick wooded holes mixed in with more open holes to offer a great nature walk while playing a really fun game.
The course is private, but it offers all day play for any $5 non-fuel purchase at Sewee Outpost.
© 2016 Moultrie News an Evening Post Industries company. All Rights Reserved.
Registration on or use of this site constitutes acceptance of our Terms of Service, Privacy Policy and Parental Consent Form.


text:
Top Definition
A prison where Maltese teen agers are sent to if they don't pass the necessary o levels. It is located in Naxxar, Malta
Noooo i didnt get maths! I'm gonna be sent to Giovanni Curmi Higher Secondary school with that bitch Miceli!
dodane przez baa baa black sheep have you any wool kwiecień 14, 2005
Trending Now
Can you define these popular missing words?


text: At the University of Waterloo Stratford Campus we offer undergraduate and graduate studies. Campus initiatives also include research opportunities, commercialization and community outreach to provide a broad range of opportunities for our students and partners. This new collaborative education style accelerates knowledge and innovation by bringing together students, leading researchers, businesses and entrepreneurs to advance digital media technology and creative application.


text:
Peta Murgatroyd is looking at the glass half full.
Although the ballroom pro was wiping away tears backstage after she and partner Gilles Marini were eliminated on Tuesday night's Dancing with the Stars, Murgatroyd, 26, is excited to spend time with boyfriend Maksim Chmerkovskiy, who was also eliminated alongside his partner, Kirstie Alley.
"We get to sleep in tomorrow morning probably, and go have breakfast, which we have not done for months," Murgatroyd told PEOPLE. "So, there's a plus side."
Even so, Murgatroyd wishes her beau and his partner didn't share her dismissal.
"I'm sad for them," she said. "Kirstie was great. She improved every week. Maks really worked hard with her and they really worked hard together."
As for her own elimination, last season's winner said with a smirk, "I'm pissed! ... I do think Gilles should be in the finals."
Marini, who says he "would work until I dropped dead," played coy when asked if he wishes he hadn't put so much effort into the show.
"Very good question," he told reporters. "I plead the Fifth. No regrets because I met Peta, and no regrets because I met Peta."
Peta Murgatroyd & Maksim Chmerkovskiy Will Sleep In After DWTS Elimination
Jim Smeal/BEImages


text:
City electrician Mike Bibbee works on mounting the latest mural by Salem artist Robert Schuck on the front of a building at 350 and 360 E. State St. in downtown Salem Thursday. Part of a project known as Murals of Salem, the 6- by 24-foot copy of four panels painted by Schuck depicts numerous images from Salem history. The mural is near the intersection of State Street and South Broadway.
Article Photos
Morning Journal/Mary Ann Greier


text:
Developers of DTC Genetic Testing Are...
Expanding Use of NGS Has Largely...
As Immunotherapy Revolutionizes the Cancer Treatment...
LC-MS Gains Favor Due To the...
Scientists working at the Mayo Clinic say they have modeled the temporal accumulation of Beta amyloid plaques in the brain linked to decline in memory and thinking abilities. The study appeared in the online edition of Neurology on February 27th.
Knowledge of the temporal pattern of plaque deposition, could, the Mayo scientists said, identify the optimal time during the course of its accumulation that therapeutic intervention might prove most effective.
In their study, plaque accumulation over time was assessed using serial amyloid position emission tomography (PET) imaging to test individuals, aged 70–92, who were enrolled in either the Mayo Clinic Study of Aging or the Mayo Alzheimer's Disease Research Center.
Study participants included 205 individuals classified as cognitively normal and 55 as cognitively impaired (47 mild cognitive impairment and 8 Alzheimer's dementia). All underwent two or more serial amyloid PET. The investigators measured baseline amyloid PET relative standardized uptake values (SUVR) and, for each participant, estimated a slope representing each patient's annual amyloid accumulation rate.
The data implied a roughly 15-year interval from an SUVR of 1.5 to 2.5. This period during which the slope of the amyloid SUVR vs. time curve is greatest and roughly linear represents, they said, a large therapeutic window for secondary preventative interventions. The study found that the rate of buildup accelerates initially, and then slows before plateauing at high levels. The rate of plaque accumulation was highest in those with mid-range levels at the start of the study. Those with low levels or high levels of the plaques as the study began had lower rates of plaque buildup.
The authors said their data implied that therapeutic interventions designed to reduce the rate of new amyloid deposition (noting the distinction from removing previously deposited amyloid) may be less effective in patients who have already reached plateau levels of amyloid deposition.
Lead study author Clifford Jack, Jr., M.D., a Mayo clinic radiologist and the Alexander Family Professor of Alzheimer's Disease Research at Mayo, said that the study supports the role that plaque formation in the brain plays in a decline in memory and thinking abilities, and takes about 15 years to build up and then plateau.
"Our results suggest that there is a long treatment window where medications may be able to help slow buildup of the amyloid plaques that are linked to cognitive decline," he noted. "On the other hand, trying to treat the plaque buildup after the amyloid plaque load has plateaued may not do much good."
Interestingly, the study also found that the rate of buildup of plaques was more closely tied to the total amount of amyloid plaques in the brain than other risk factors, including level of cognitive impairment, age, and the presence of the APOE gene, a gene linked to Alzheimer's disease.
To save this item to your Favorites,
log into GEN Select.
We'll be sure to take you back here after you do.
Not a member of GEN Select?
To comment on this article,
log into GEN Select.
We'll be sure to take you back here after you do.
Join 110,000 colleagues who rely on GEN Highlights for breaking news and exclusive articles shaping today's life science tools and technologies.
You're all set! Thank you for subscribing to GEN Highlights.
Novum Pharma recently raised the price of an acne cream by over 3,900% in less than a year-and-a-half and Mylan increased price of EpiPen from $100 to $608 . Do you think pharmaceutical companies need to be subjected to price controls?
Be sure to add [email protected]
to your Address Book or Safe Senders List.
here for instructions.
If you have any questions about your subscription, click
here to email us or call at (914) 740-2189.
You may also be interested in subscribing to the GEN magazine, an indispensable
resource for everyone involved in the business of translating discoveries at the
bench into solutions that fight disease and improve health, agriculture, and the
environment. Subscribe
today to see why over 60,000 biotech professionals read GEN to
keep current in the areas of genomics, proteomics, drug discovery, biomarker discovery,
bioprocessing, molecular diagnostics, collaborations, biotech business trends, and
© 2016 Genetic Engineering & Biotechnology News All Rights Reserved


text:
Greenville getting "extreme" trampoline park
Greenville will be getting a trampoline park attraction this summer.
The Greenville News reported that Gravitopia will offer more than 10,000 square feet of trampolines.
The company says it also is offering an aerial obstacle courses, trampoline dodge ball, foam pits, trampoline aerobics and will host birthday parties.
Gravitopia will also host dodge ball tournaments, trampoline aerobics classes, and weekend club nights with laser lighting and a live DJ.
Customers will play between $8 and $12 per hour for jumping time.
Owner Lawrence Case says the company has similar parks in Alabama, California, New Mexico, Oklahoma, Tennessee and Virginia.
Copyright 2013 by The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
LISBON - The Columbiana County Emergency Management Agency will face the effects of Hurricane Sandy with only an interim director after the new deputy director resigned.
Samantha Works, who was hired in July as deputy director, resigned to return to her job as a case manager/drug and alcohol dependency counselor at the Northeast Ohio Community Alternative Program in Warren, a prison alternative facility for convicted felons.
Works' last day was Oct. 26, leaving only interim EMA Director Edie Dillard to face the heavy rains and high winds the National Weather Service was expecting to arrive last night and continue into this morning.
Dillard, who has worked at the EMA since 2006, said she has taken the usual steps, such as placing all fire departments and other first responders on alert. The local chapter of the Red Cross is also on standby and prepared to open emergency shelters within an hour if needed.
She said they have also made arrangements with the Highlandtown Fire Department to use 10,000 sand bags stored there in case of flooding. The sand bags were purchased several years ago by the EMA, and Highlandtown agreed to let them be stored there.
The National Weather Service predicted the county could receive between two to four inches of rain between 8 p.m. Monday and 4 a.m. today, including wind gusts of up to 60 mph.
Dillard believes widespread power outages pose a greater threat to the county than flooding, but they are prepared for both. She said AEP and FirstEnergy (Ohio Edison), the county's two electricity suppliers, were also on alert for outages throughout Ohio.
"This is just like what we do with any other storm: Listen to the weather service, see how the wind blows and take the normal precautions," she said.
The last major hurricane to strike the county was Hurricane Ike in September 2008, when wind gusts of 60 to 70 mph knocked out power to 38,000 households, many of whom were without electrical service for up to a week afterwards.
Dillard was named interim director by county commissioners following the July resignation of Director EMA Darren Dodson. Commissioners later rejected the list of finalists recommended by the review committee to replace Dodson. The committee consisted of Dillard; a representative from FirstEnergy, which provides the majority of EMA funding; and the local representative from the Ohio EMA assigned to the county.
Two of the three commissioners said the committee was unenthusiastic about the list of applicants, which is why they have held off and are considering readvertising the job. Their decision to do so has been criticized by one of the candidates running for commissioner in the Nov. 6 election.
Commissioner Jim Hoppel said Dillard has provided them with the names of two former applicants she believes would be good candidates for the deputy director position.
"We'll take a look at them," he said.


text:
Ramard Total Joint Care
Ramard's Total Joint Care is a synergistic blend of the most powerful joint care products available to support joint comfort and mobility in horses. 510 gm (30-day supply). Read more...
Ramard's Total Joint Care for horses offers a highly effective synergistic blend of powerful joint care products. Total Joint Care focuses on the entire joint: soft tissue, tendons and ligaments to stimulate cartilage production and reduce degradation. It helps replenish synovial fluid which cushions and lubricates joints. Contains 200 mg hyaluronic acid, 6000 mg glucosamine HCL, 3000 mg chondroitin sulfate sodium, 3000 MSM, 1000 mg vitamin C, 50 mg zinc. No fillers or additives. 510 gm (30-day supply).
100% Satisfaction Guaranteed - Your Money Back Any Time, for Any Reason.
Smith Brothers is proud to offer a 100% satisfaction guarantee on all of our products. We stand behind the quality of our products, and should you not be satisfied with your purchase, simply return it and we will refund, replace or exchange it for you.


text:
SCID Center Faculty/Staff
Associate Professor of Microbiology and Immunology
Director, Center for Humanized SCID Mouse Models
Dr. Moffat studies the interaction of varicella zoster virus (VZV) with human cells and tissues. VZV can infect skin and thymus that is implanted into SCID/beige mice (SCID-hu), which provide two models for understanding the virus-host interaction in whole tissues. Compounds that inhibit these essential kinases have antiviral effects that are currently being evaluated in skin organ culture and in the SCID-hu mouse model.
Professor and Chair of Microbiology and Immunology
Dr. Rochford has extensive experience in EBV-associated malignancies as well as hu-PBL SCID models. Her laboratory has developed a lymphoma cell line that expresses the luciferase gene allowing for imaging of tumor growth in living animals. Using this technology, she is testing new anti-cancer compounds in the SCID mouse model. She is also developing models to test anti-malarial drugs in humanized SCID mice.
Associate Professor and Chief of Infectious Disease, Department of Medicine
Dr. Endy has extensive experience in dengue hemorrhagic fever and emerging diseases. His laboratory is currently developing an animal model for dengue hemorrhagic fever using humanized SCID mice.
Research Administrator for the Center
Ms. Chanantry's responsibilities include sponsored program submissions, fiscal management, and compliance.


text:
Hey True Believers!
Here it is, the last of the Halloween looks! I've been super excited about doing this version of Monster High's Clawdeen Wolf as Little Dead Riding Wolf for you all! Clawdeen is my favorite doll in the series and the original version I did of her last year was so well received, that I felt a sequel was due this Halloween! I bought the doll above and thought she was so pretty and the idea of her as Little Red Riding Hood was so cute and clever, that I decided I wanted to be her for Halloween and do a makeup for you all!
I went with the makeup that was shown on the drawing of her because it was a little more interesting with the red on the border of the purple. I also altered the shape a little to fit my eye better. Of course I could have went TOTALLY cartoony with it, but I wanted to also make it a little more real world.
My ears were custom-made by my awesome friend Aubriana,The Mad Masker, who also loves the Monster High dolls as well (Lagoona is her favorite because she's a huge fan of The Creature from the Black Lagoon😉 )! Go check out her work, she's amazing and if you want, put in an order with her to make you something awesome!!
The wig was a hodge-podge of wig and hair pieces from Arda Wigs.
The teeth were custom-made and molded to my teeth by my friend Leo at Cavallero Fangs.
The contact lenses were the Vassen Hanabi Gold from Pinky Paradise.
The costume was made by myself and my mother, and I changed it a bit to make it more mine.
I hope you all like it!


text:
TAHOE CITY, Calif. - One person suffered minor injuries in an early Sunday morning fire that destroyed a home near Lake Tahoe's West Shore, an official said Monday.
Crews with the North Tahoe Fire Protection District responded at about 3:04 a.m. Sunday to the residence at 491 Club Drive in the Talmont area of Tahoe City, said NTFPD Public Information Officer Dave Zaski.
Firefighters found the home engulfed in flames, with its three occupants standing outside. One of the occupants suffered minor injuries and was transported to Tahoe Forest Hospital; the victim was released later Sunday.
The residents were all adults in their 30s and renters of the home, Zaski said.
While no one else was hurt, Zaski said in a follow-up interview Tuesday that two of the home's dogs were missing as of Tuesday, and a third dog could also be missing.
The fire's cause is being investigated, Zaski said. No other structures were threatened.
According to North Tahoe Fire, the temperature during the time of the blaze hovered around -7 degrees. Despite the bitter conditions, no firefighters were injured, Zaski said, due in part to the establishment of a rehab unit that provides a warming shelter for fire personnel in extremely cold conditions.
Crews from the Truckee, Northstar and North Lake Tahoe (Incline Village) fire protection districts also assisted in knocking down the flames.


text:
I tried to make traditional calaveras (skulls) out of sugar for Dia de Los Muertos, (Day of the Dead on November 2nd), but they didn't come out very well because my local Latino markets didn't have the molds I wanted to use. I decided I would make them another way.
I saw a creative Etsy crafter had used felt, and was going to make some like that, but then I happened upon ceramic skulls at The Dollar Tree. They were actually 2 for $1.
With just a little craft paint and some creativity – Ta da! A calavera for Dia de los Muertos :)
If you want to make one, too, go check your local dollar stores for clearance Halloween decorations. ¡Diviértanse! (Have fun!)


text:
To encourage project location in areas with development constraints and promote the health of the surrounding area.
Option 1. Historic district (1 point BD&C except Core and Shell, 2 points Core and Shell)
Locate the project on an infill location in a historic district.
Option 2. Priority designation (1 point BD&C except Core and Shell, 2 points Core and Shell)
Locate the project on one of the following:
- a site listed by the EPA National Priorities List;
- a Federal Empowerment Zone site;
- a Federal Enterprise Community site;
- a Federal Renewal Community site;
- a Department of the Treasury Community Development Financial Institutions Fund Qualified Low-Income Community (a subset of the New Markets Tax Credit Program);
- a site in a U.S. Department of Housing and Urban Development's Qualified Census Tract (QCT) or Difficult Development Area (DDA); or
- a local equivalent program administered at the national level for projects outside the U.S.
Option 3. Brownfield remediation (2 points BD&C except Core and Shell, 3 points Core and Shell)
Locate on a brownfield where soil or groundwater contamination has been identified, and where the local, state, or national authority (whichever has jurisdiction) requires its remediation. Perform remediation to the satisfaction of that authority.
Join LEEDuser
Ask questions, share tips, and get notified of new forum posts by joining LEEDuser, a tool developed by BuildingGreen and supported by USGBC!
Sample forms
Active Form


text:
NILES - A local cash advance business was robbed today.
About 10:53 a.m., Niles police responded to a 911 call for a robbery at National Cash Advance on Youngstown Warren Road in Niles.
Niles police Capt. Ken Criswell said the suspect is a black male in his 20s or 30s, wearing a light gray / white hoodie. He also was wearing a hat with flaps or tassels hanging down.
Article Photos
The suspect said he wanted to get a money order before declaring, "This is a robbery," according to Criswell.
An undisclosed amount of cash was taken.
There were no injuries.
For the full report, see Thursday's Tribune Chronicle.


text:
My Personal favorite:
Which team has the better overall team defense, Detroit or Pittsburgh?
Burnside: OK, the Wings have better defensemen, but that's not the same as team defense. And I think the Penguins' ability to roll four lines for long periods of time makes them, overall, a better defensive club. Plus, they have a slight edge in goaltending, which goes to team defense, too.
Edited by PaVel DaTsYuK fan13, 25 May 2008 - 03:24 PM.


text:
National Institutes of Health (NINR, NHLBI)
Neurobehavioral Effects of Partial Sleep Deprivation [NINR]
Principal Investigator: David F. Dinges, Ph.D.
This project continues an innovative line of research on how to optimally use sleep as an intervention to promote cognitive recovery from, and resistance to, the neurobehavioral risks posed by chronic partial sleep deprivation. Chronic insufficient sleep is estimated to affect at least 20% of adults. It can result from medical conditions and sleep disorders, as well as work demands, and social or domestic responsibilities. It is associated with significant clinical morbidity, and directly causes errors and accidents that are due to its adverse neurobehavioral effects on alertness, mood, and cognitive functions.
In seminal experiments conducted under this grant, we showed that the neurobehavioral effects of chronic sleep restriction accumulate to severe levels in a few days, without the full awareness of the affected individuals, and that recovery from chronic sleep restriction requires more sleep than previously assumed. We also discovered that recovery from chronic sleep was illusory, because it masked a heightened neurobehavioral vulnerability to even a single post-recovery night of sleep restriction. The implications of these findings are that apparent recovery from chronic sleep restriction masks a more severe cognitive response to subsequent sleep restriction suggesting that there are longer time constants in the brain for neurobehavioral recovery from chronic sleep restriction. In light of this finding, we now seek to determine whether additional nights of extended recovery sleep will reduce the heightened vulnerability induced by prior exposure to sleep restriction.
A total of 110 adults will be studied in the laboratory during a 17-day protocol evaluating cognitive, psychological and physiological responses to varying recovery days between two sleep-restriction periods. The results will establish the number of nights of recovery sleep needed to prevent accelerated deterioration during a subsequent period of sleep restriction. The findings will advance theoretical understanding of sleep homeostasis and its relationship to cognitive functions, as well as inform theories of sleep need, and have substantial implications for sleep biology, for the treatment of clinical disorders that regularly disrupt sleep, and for managing lifestyle factors that frequently restrict sleep.
Neural Basis for Differential Vulnerability to Sleep Deprivation [NINR]
Principal Investigator: Hengyi Rao, Ph.D.
Sleep loss increases sleep propensity, destabilizes the wake state, impairs psychomotor and cognitive performance, and causes considerable social, financial and health-related costs. Although insufficient sleep is a risk factor for obesity, cardiovascular disease and diabetes, depression, and prospective mortality, about 20% to 40% of the US adults sleep less than the minimum sleep duration (7-8 hours per night) to prevent cumulative deterioration in cognitive performance. Neurobehavioral evidence from our previous studies and other groups has indicated robust and highly replicable (trait-like) individual differences in the magnitude of sleepiness and cognitive performance vulnerability to sleep deprivation.
While some healthy adults show substantial cognitive deficits during sleep loss, others show few cognitive changes when sleep is deprived. However, little is known about why some sleep-deprived people are more prone to cognitive deficits that can result in costly errors and accidents. To answer this question, we propose to combine our interdisciplinary expertise in neuroimaging and neurobehavioral effects of sleep deprivation to elucidate the neural basis underlying this differential cognitive vulnerability. We will use a new technique of arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI) for quantification of resting brain activity without task and tonic activation during performance of the psychomotor vigilance test (PVT) in a large sample of N=60 healthy subjects after normal sleep and following sleep deprivation. PVT is a simple, reliable and highly sensitive task for measuring attentional and performance deficits due to sleep deprivation. We will also use traditional BOLD fMRI for measuring phasic activation during fast and slow PVT responses and functional connectivity analysis for studying brain connectivity after normal sleep and following sleep deprivation.
The findings from this project will elucidate the neural mechanisms by which sleep deprivation affects behavioral performance and how the effects of sleep deprivation vary across individuals of differential vulnerability. The new knowledge gained from this study will have relevance for understanding and managing excessive sleepiness due to a number of common sleep disorders (e.g., sleep apnea and other sleep disorders; affective disorders; shift work sleep disorder). The project also has the potential to yield brain-based biomarkers that can be used to predict individual responses to sleep deprivation and its treatment.
Back to Top


text:
NSCLC is "Major Battlefield" as Merck,...
As Immunotherapy Revolutionizes the Cancer Treatment...
Wall Street Decline Takes Its Toll...
Developers of DTC Genetic Testing Are...
With the advent of new high-throughput approaches to generate vast datasets, one of the challenges is how to integrate different types of information that are sometimes generated by using distinct techniques. For example, various types of genome-scale data are currently available, particularly from cancer patients, and include microarray analyses and specific amplifications or deletions on the chromosome.
"The question is how these datasets fit together, how one can make sense out of it. That is really important, because if we find the connections between these data types, we may in fact identify the genes that drive certain diseases," says Gábor Balázsi, Ph.D., assistant professor in the department of systems biology at the University of Texas MD Anderson Cancer Center.
At the recent CHI "Molecular Medicine Tri Conference" in San Francisco, Dr. Balázsi talked about work that he and collaborators conducted to integrate mRNA and gene amplification/deletion datasets in an effort to identify genes and sets of genes that drive specific subtypes of breast cancer.
"We designed a method to put together the two types of data and, also, used existing information on protein-protein interaction and gene regulation," he explains. Based on this approach, Dr. Balázsi and collaborators, involving postdoctoral fellow Bhaskar Dutta, identified gene networks that are important in breast cancer and unveiled specific subnetworks that they termed "driver networks" to illustrate the putative importance of the participating genes in the appearance of different breast cancer subtypes.
In breast cancer, triple negative tumors pose some of the most significant therapeutic challenges. This is in contrast to estrogen-receptor positive tumors, which often respond to tamoxifen or estrogen receptor antagonists, and to Her2 positive tumors, which usually respond to herceptin.
"One of the most interesting aspects of our study is that we identified, in collaboration with Dr. Lajos Pusztai's laboratory, the gene sets for the triple negative subset of breast cancers," explains Dr. Balázsi. Furthermore, by knocking down the genes from this network in triple negative cell lines established from patients, Dr. Pusztai and colleagues experimentally confirmed that genes identified by computational analysis play a role in the survival of triple negative breast cancer cells. "The driver networks we defined from gene expression and CGH data of human breast cancer patients provided directly testable therapeutic hypotheses that suggest treatment strategies and in particular combination therapies that could and should be tested in the clinic," concluded Dr. Balázsi.
One of the most important and clinically relevant aspects related to gene expression is the need to visualize it as a highly dynamic process. "Overall, gene expression changes as tumors progress. The tumor microenvironment affects gene expression, and epigenetic modifications bring a significant contribution to this," says David S. Hoon, Ph.D., director of the department of molecular oncology at the John Wayne Cancer Institute. One of the research efforts in Dr. Hoon's laboratory, particularly over the past eight years, has focused on studying gene-expression changes that occur during cancer progression and metastasis, particularly from an epigenetic perspective.
Dr. Hoon and colleagues recently reported that RUNX3, a gene that exists in most cell types and appears to be important for development and cell differentiation, shows abnormal expression in primary and metastatic cutaneous melanoma. This work revealed that two epigenetic mechanisms, miRNA and promoter CpG hypermethylation, suppress RUNX3 mRNA levels in primary tumors as compared to untransformed cells, and an intriguing finding was that this suppression was even stronger in metastatic melanoma.
"An important aspect to remember is that we often assume that the gene-expression profile of a metastatic tumor will be the same as in the primary tumor, and we often treat based on the primary tumor, but this is not always correct," emphasizes Dr. Hoon. The existence of gene-expression differences between primary and metastatic tumors represents a clinically relevant aspect that underscores the necessity to explore the epigenetic and gene-expression profile for both the primary and metastatic tumor, because they may be different in the same patient.
The interplay between genetic and epigenetic changes is emerging as one of the most exciting and thought-provoking developments from recent years. Increasingly, findings from multiple biomedical fields have converged to illustrate the concerted contribution of genetic and epigenetic factors as they shape gene expression. The reversible nature of epigenetic changes opens the possibility to monitor or modulate their impact on gene expression and promises attractive prophylactic, diagnostic, and therapeutic applications.
To save this item to your Favorites,
log into GEN Select.
We'll be sure to take you back here after you do.
Not a member of GEN Select?
To comment on this article,
log into GEN Select.
We'll be sure to take you back here after you do.
Novum Pharma recently raised the price of an acne cream by over 3,900% in less than a year-and-a-half and Mylan increased price of EpiPen from $100 to $608 . Do you think pharmaceutical companies need to be subjected to price controls?
Be sure to add [email protected]
to your Address Book or Safe Senders List.
here for instructions.
If you have any questions about your subscription, click
here to email us or call at (914) 740-2189.
You may also be interested in subscribing to the GEN magazine, an indispensable
resource for everyone involved in the business of translating discoveries at the
bench into solutions that fight disease and improve health, agriculture, and the
environment. Subscribe
today to see why over 60,000 biotech professionals read GEN to
keep current in the areas of genomics, proteomics, drug discovery, biomarker discovery,
bioprocessing, molecular diagnostics, collaborations, biotech business trends, and
© 2016 Genetic Engineering & Biotechnology News All Rights Reserved


text: This looks like the current IV.v, with Aufidius. Kemble's performances as Coriolanus were regarded as some of his best, with his sister Sarah Siddons as Volumnia. Artist: F. Bourgeois; print by B. B. Evans, 1798; from Harry R. Beard Collection, given by Isobel Beard; courtesy of the Victoria and Albert Museum, London.


text:
Getting 10+ each of any two of the following categories in a game of basketball: points, rebounds or assists. Related to "Triple Double" which is 10 or more of all three in a game. Literally double (2 of) double (digit stats).
In last night's game, he scored 14 points and had 10 rebounds, for his first double-double of the season.
ironsman tarafından 12 Ocak 2006, Perşembe
2 glasses of wine, followed by 2 shots of espresso
;Cures sleepless anxiety
;Normally a lunch time fix
;Cures sleepless anxiety
;Normally a lunch time fix
Hey Stephanie! Lets go to that Irish Pub, then to Starbucks, cuz i need a double double STAT!
sweetgrassnyc tarafından 2 Eylül 2011, Cuma
A gymnastics term for one of the most difficult backwards somersaults, where the gymnast completes two back flips and two twists all in one somersault.
"Her fourth place finish was totally unfair, she's the only gymnast at the Olympic games competing a double-double."
Shawn Johnson tarafından 5 Ocak 2013, Cumartesi
When a man receives oral sex from a woman while his penis is folded over in her mouth. Simulating two male weiners in her mouth.
I want to fit your double double in my mouth.
Dude von Dudenstein tarafından 16 Temmuz 2010, Cuma
When someone goes to second base on a girl using both hands on both breasts at the same time.
Sam wasn't satisfied with going to second base once and wasn't quite ready to get to work on her third base, so he lifted the bra off of Sandy's other boob and worked on that. It was a textbook double-double.
Somebody Else Somewhere tarafından 6 Temmuz 2011, Çarşamba
In basketball, a term referring to an accomplishment reached by a player who has 10+ in two statisticaly categories in one game.
The "double double" refers to "two stats in two digits"
The "double double" refers to "two stats in two digits"
Tim Duncan had another double double the other day, he's sick!
good face for radio tarafından 4 Aralık 2005, Pazar
In basketball, getting two sets of 10 in statistics
Double stands for 2, and then the second double stands for 2 sets of 5
Double stands for 2, and then the second double stands for 2 sets of 5
I got a double doube with 40 points and 10 rebounds.
pwnz0r tarafından 17 Eylül 2003, Çarşamba


text:
Strength through opposition
January 5, 2013
Grover Cleveland, it was said, engendered affection among Democrats because of the "enemies he has made....
Neither of these are correct. The PEOPLE need to educate themselves and become LESS gullible to all politicians lies and deceit. The PEOPLE need to vote smarter and more intelligently and stop letting lying politicians tell them what they want to hear. Until the PEOPLE wise up, nothing changes.
In "reality" there's NO difference in each of these parties. They BOTH do the same to the people and the only thing each party hates is when they aren't the ones in power to do the same crooked things to the citizenry. WHen the citizens realize what both are doing to them; then we get more honest, caring politicians and not the bottom of the barrel frauds.
2 Agrees | 0 Disagrees | Report Abuse »
Compromise food with poison and what do you get?
Poisoned. America today is on its deathbed, thanks to Liberal poison.
No more, thanks.
5 Agrees | 0 Disagrees | Report Abuse »
Showing 2 of 2 comments
Post a Comment
You must first login before you can comment.


text:
|Assistant Athletic Director / Head Coach - Softball
|(207) 554-7787
Sara Shaw begins her first season at the helm of the Owls softball program in 2015.
A 2008 graduate of UMaine-Farmington, Shaw possesses a wealth of softball coaching and strength and conditioning experience including a stint as the assistant softball and basketball coach at Maine-Presque Isle in 2010.
Shaw is the owner of FitLife Personal Fitness Training, where she develops fitness programs for a wide range of clients and was most recently the Director of Parks and Recreation for the town of Limestone, Maine from 2012 to 2014.
"I am extremely excited to begin working with this wonderful group of athletes," Shaw said. "I have always loved being involved in the game of softball, whether it was as a player or a coach; and I really believe in UMPI's vision for its student-athletes. UMPI is a great fit for me. "
Shaw is no stranger to playing athletics at a high level, having competed in five conference championships as a softball and basketball player in the Yankee and North Atlantic Conferences while at Central Maine Community College (CMCC) and Maine-Farmington. Both of Shaw's parents are long-time coaches and she has worked in and around athletics her entire life.
Included in her past experiences, is a stint at CMCC as Assistant Athletic Director and Sports Information Director in 2008. She has also worked at various camps, fitness centers and was the varsity softball coach at Mt. Abram High School in Salem, Maine.
While at CMCC, Shaw worked closely with Athletic Director and USCAA president Dave Gonyea. Maine-Presque Isle is dually affiliated with both the NCAA and USCAA and her background with both organizations will be utilized to promote the softball program at UMPI.
Shaw earned her undergraduate degree from Maine-Farmington in community health education in 2008 and is one course away from earning her master's degree in sport management from the United States Sports Academy. She is also the co-owner of Northern Athletic Supply in Presque Isle, Maine.
"I look forward to bringing energy and excitement for the game of softball to this program and building on the great work previous coaches before me have done," said Shaw. "I'm excited to meet the girls and begin working with them!"