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Hoard's Dairyman: Err on the side of safety to avoid milk residues
Err on the side of safety to avoid milk residues
This article is from the website of NMC, a global organization for mastitis control and milk quality. See nmconline.org. It was adopted from the University of Illinois extension veterinarian, Dick Wallace, D.V.M.
When a cow needs medication, the first treatment step (before any medications are administered) should be the application of some form of semi-permanent identification. You should use at least two different identification methods. These may include leg bands, chalk marks, tail tape, neck chains, or some other form of secure identification that can be removed easily when the withholding time has expired.
• When FDA-approved drugs (for dry and lactating cows) are used according to the label directions, you should follow the recommended withholding times. Extensive product evaluations by drug manufacturers have built safety factors (required by the FDA) into the established withholding times. These safety factors are 100 to 1,000 times lower than the lowest dose expected to cause a violative residue in milk.
Drugs used in an extra-label manner MUST be used within the context of a valid veterinarian-client-patient relationship. Extra-label treatments DO NOT have established withdrawal times. Therefore, the prescribing veterinarian must supply a withdrawal time for meat and milk sufficient to assure food safety. Administering two or more FDA drugs into one cow at the same time is considered extra-label drug use.
Extra-label use also includes changing the dosage and frequency or route of administration, and may result in violative residue. Even though FDA-approved medications are used according to label directions, extended withholding times may be needed for cows that calve earlier than expected, cows that are severely ill, or cows that do not respond to label treatments.
• Milking all treated cows AFTER untreated herdmates is an important preventive measure and strongly advised. Milk dump-buckets connected to pipeline vacuum can overflow or be tipped, allowing contaminated milk to enter the system.
• Although milk residue tests are not designed or approved for individual cow testing, milk from all purchased cows should be evaluated for residues by a test kit that detects the same drugs as the farm's milk processor. This should occur before commingling purchased-cow milk in the bulk tank. It may be prudent to discard milk from purchased additions for at least eight milkings regardless of milk residue test results.
• Using the same milking unit on treated and untreated cows without thoroughly cleaning and sanitizing between cows is a violation of the Pasteurized Milk Ordinance. Extremely small quantities of contaminated milk can result in bulk tank residues.
• Segregate treated cows from lactating cows, preferably in a separate facility. Physical isolation will reduce the potential for unintentional commingling of treated dry cows with the lactating herd. The farm specific, two-way identification system mentioned previously should make it simple for the people milking to easily recognize antibiotic-treated cows.
• Prior to milking, hang a treated cow list from the bulk tank swing line. Temporary parlor (milking) downtime should occur between milking untreated herdmates and treated cows. Even if untreated cows remain in the parlor as "place holders," all milking units should be removed and readied for the medicated milking string. To retrieve the treated-cow list from the swing line, you must enter the milk house. Before removing the treated-cow list, pull the swing line out of the bulk tank. Use the treated-cow list to cross-check the remaining cows to ensure that all treated cows have been withheld.
• The practice of using medicated foot baths to control hoof diseases has some scientific basis. Once manure accumulates in the foot bath solution, the efficacy of the medication may be reduced dramatically. Consider treating individual lame cows with sprays, corrective hoof trims, or both to reduce the potential for residues.
• Don't use medicated feeds to control diseases in lactating cows.
• All FDA-approved drugs designed for intramammary use will be absorbed into a cow's bloodstream after infusion into a quarter. Discard milk from all four quarters, regardless of which quarter was treated.
Ten common reasons antibiotic contamination occurs in bulk tank milk*
1. Milk from a treated cow was accidentally routed into the pipeline.
2. An antibiotic-treated dry cow was unintentionally milked.
3. The same milking unit was used to milk an antibiotic-treated cow before milking untreated cows. The milking unit was not cleaned and sanitized between uses.
4. Lactating cows were purchased, and the new owner was unaware of recent antibiotic treatments prior to sale.
5. One quarter of a cow was treated for mastitis and withheld from the bulk tank. However, milk from the other three quarters was NOT withheld and was permitted to enter the pipeline.
6. Equipment used to milk treated cows was handled carelessly; for example, vacuum from the milk pipeline was used to operate dump-milk buckets.
7. All antibiotic-treated dry cows were milked last, but the milk line was not diverted from the bulk tank.
8. Antibiotic residues remained in the milk of a cow that was treated in an extra-label fashion. These are the cows which should be tested individually.
9. Medicated feed was accidentally mixed into the lactating-cow feed.
10. Cows drank from a medicated foot bath.
*Supported by the Minnesota Department of Agriculture Dairy and Food Inspection Division, the University of Minnesota, College of Veterinary Medicine, Department of Clinical and Population Sciences, the Minnesota Milk Producer's Association, and the Minnesota Veterinary Medical Association.


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Technical information
Begin of tour: Cable-car station Murtèl (halfway station of the Corvatschbahn)
End of tour: Bottom station of the Corvatschbahn, Surlej
Access starting point: Bus from St. Moritz to Surlej and cable-car Surlej - Corvatsch
Access point of arrival: Buses to St. Moritz
Technical requirements: Average
Physical fitness: Easy
Total altitude meters: Fall of approx. 850 m
Hiking time: 3 hrs. 10 min.
Season: July to October
Gastronomy: Murtèl, Hahnensee, Surlej
Overnight: Surlej, Silvaplana
Various: Views of the Engadine lakes, Hahnensee
Literature: www.karten-shop.ch
Murtèl (middle station of the Corvatschbahn) - Fuorcla Surlej - Hahnensee - Surlej
The descent from Murtèl to the Hahnensee must fall into that category, offering as it does stunning views in all directions. In the higher section of the walk, your gaze is drawn to Piz Corvatsch and Piz Bernina. Lower down, there is a magnificent panorama of the Champèrer, Silvaplana and Sils lakes.
The first part of the tour leads on a wide path from Murtèl towards Fuorcla Surlej. Shortly before the final climb up to Fuorcla, a narrow path leads off to the left. This is the start of the wonderful descent to the Hahnensee. The final part of the walk passes through beautiful pine forests down to Surlej.
Tour Overview
3D hiking map Download GPX coordinates Download KMZ (GoogleEarth)
The careful planning of a tour will ensure that you also derive the maximum pleasure and enjoyment from it. Please take the time to contact the local information centre and enquire about route and weather conditions before setting off. Your intended trail may be fully or partially closed, depending on the time of year and weather conditions.

subset: commoncrawl


text:
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elsa is 5.
48 comments:
You have a beautiful family. I love the family pic.. 8 pairs of eyes looking at the camera is no small thing...ReplyDelete
Happy birthday Sweet girl.. I hope you feel super special and loved.
Happy thoughts all the way from New Zealand on your birthday weekend.
I love love love that family picture!!ReplyDelete
happy birthday sweet girl, you are loved! what a sweet party, I'm sure she felt so honored!ReplyDelete
That family photo needs to be framed! Too cute. But ya shoulda came to Tampa! Gosh! :)ReplyDelete
Happy birthday Elsa! She is gorgeous! I absolutely adore your family picture. Your family is so beautiful. :)ReplyDelete
Happy, happy birthday to sweet Elsa. Love all the pics, and that family pic is GORGEOUS! How is it possible that you are still as thin as you were before you had sweet Olive?? I am so jealous!ReplyDelete
What a great family photo. I just realized you look awesome for someone who gave birth to five kids. You normally only have photos of your face.ReplyDelete
Happy birthday to your little girl! I'm sure any way you celebrate her birthday is special, beach house or just at home with family and friends.
I grew up in a family of 7 kids - our birthdays were similar to this, just our family & close cousins - and I remember them all to well :) (that's a good thing!) Looks like such a happy family!ReplyDelete
love the family picture, so great!ReplyDelete
happy birthday elsa!
Happy Birthday Elsa!!!!!!ReplyDelete
love, love, love all the pics. I especially adore the family pic. I know how hard it is to get all eyes on the camera. Happy birthday to your sweet girl, Elsa.ReplyDelete
It looks like a very special and happy birthday to me!ReplyDelete
Love your family photo!
that photo is great! happy birthday, elsa!ReplyDelete
Happy Birthday to Elsa! I am beyond thrilled that you got that lovely picture! I think you should just make it your holiday photo and call it a day!ReplyDelete
sweet Elsa looks so happy! I bet she was over the moon. And what an awesome family picture!!!! I can't even get a picture of me and my husband that I like and you have 6 kiddos!ReplyDelete
It's the simple things that we remember...my oldest (15) can always recap all the fun, easy things we have done over the years...and can barely remember the Disney trips...should have saved a few bucks!ReplyDelete
Happy birthday Elsa!!!
Happy Birthday Sweet Elsa!! And I love the family pic, by the way!ReplyDelete
yay happy birthday beautiful girl! glad your day was filled with special love :) that family pic rocks! please show us the frame that it will be going in :)ReplyDelete
dang u r one cute family! :) Happy sweet bday to Elsa...giv her a hug for me :)ReplyDelete
HAPPY BIRTHDAY ELSA!!!ReplyDelete
now THAT sounds perfectly special!!!!!!!
i'm in love with elsa. she is just such a treasure. and also, how is she 5??ReplyDelete
5! So exciting.ReplyDelete
Happy Birthday to your sweet girl.
Yay! Happy Birthday Elsa!ReplyDelete
Love the family picture. Happy Birthday Sweet Elsa. We share a birthday.ReplyDelete
awe, she's just so so adorable!ReplyDelete
Looks like she thought it was pretty special.
Happy Birthday to Sweet Little Elsa.
yay for the birthday girl and her sweet celebration!ReplyDelete
and double yay for a family picture where everyone is looking at the camera! you are a beautiful family!!!
Happy Birthday sweet girls. Love from the Irvin family.ReplyDelete
What an amazing family photo :)ReplyDelete
And I bet to Elsa, it was a totally awesome birthday. I find myself trying to outdo myself sometimes too... but we have to remember to a child all they want is you. Your time. Your attention. Maybe a few gifts and a birthday cake :)
Looking back at my childhood, I was the youngest of four- and birthdays were always simple because we didn't have a lot of money. But I was surrounded by those I loved, and what I remember most is everyone singing happy birthday to me. They are perfect memories and I always felt on top of the world.
Happy Birthday Elsa!
Happy Birthday Elsa!!!ReplyDelete
You should receive an award for getting everyone to look at the camera! I'm lucky if I can get my family of THREE to do that! Happy Birthday, Elsa!ReplyDelete
Happy Birthday Elsa! Love how she's looking at her cupcakes in the picture with her brother. Cupcakes with family and friends in the backyard was probably better than any trip away to celebrate. great shot of all of youReplyDelete
Happy birthday, Elsa! She's so adorable. Looks like you guys had a great time! :)ReplyDelete
Oh I just LOVE HER!ReplyDelete
she's so beautiful and precious!
happy 5th birthday Elsa darling!
Happy Birthday Elsa. Sounds like she loved it.ReplyDelete
I posted today about my granddaughter's birthday party that go cancelled. We ended up having quite a good time with some quick on our feet replacement fun.
She looks so good and healthy! I love her hair in those puffy ponytails. She so pretty ;)ReplyDelete
Sometimes, its not the amount of money we spend or where we go but quality of the people we spend our time with and the amount of amount of memories made <3 Happy Birthday Elsa.ReplyDelete
Happy birthday sweet girl! It was special because she was with her family who loves her so dearly! ;)ReplyDelete
I love these pictures with her and the cupcakes. She looks so HAPPY! and why wouldn't see? She has such a great family AND cupcakes!!!!! Congrats on the family picture. My family still can't get that down and we're all adults!ReplyDelete
How precious! Great pics! Happy birthday Elsa!ReplyDelete
It looks like she had a great time! Adorable photos & very impressive family shot, even Olive is looking at the camera!!ReplyDelete
LOVE the family pic!ReplyDelete
and happy, HAPPY BIRTHDAY SWEET ELSA! :)
oh my gosh. LOVE the family pic! and happy birthday to Elsa!ReplyDelete
happy birthday from across the ocean sweet elsa!ReplyDelete
totally snorted when i scrolled that pic of Kohen blowing spit.../snort!ReplyDelete
i'm going to start a board on Pinterest for when i need to *LOL* and that pic will be my FIRST pin! yes?
happy birthday Elsa!!! XO
Yay a family picture :D and a good one too!! Nice work. Happy Birthday Elsa!ReplyDelete
i wanna cry. love the pic of all of you!!ReplyDelete
I love your big family!! Happy belated birthday Elsa!!ReplyDelete
You have a beautiful family!!! So inspirational! I just started following your blog, check mine out and follow back!!ReplyDelete
I work in a hospital Emergency Room, we see a lot of kids that end up going to foster homes, and we don't talk about it at work, but we all pray in our hearts they end up in families like yours!


text:
Top Definition
The refreshing splash of water that cools down your butt cheeks when poop hits the surface of toilet water, making the toilet paper impossible to use.
Jhonny got shmisted because his small intestine absorbed too much water, making his feces heavy.
di BorderSpice 17 febbraio 2011
Trending Now
Can you define these popular missing words?
A fine mist of faeces that is emitted from the anus upon emission of gas (flatuance), similar to, but not the same as a Shart.
Dan: Dude I think I just shmist in my pants.
di gorilla in the shmist 01 aprile 2009


text:
Main Content
Don't get stuck outside during a Philadelphia Phillies game without a warm hoodie! The Home Stretch hoodie by Majestic will keep you cozy through that last home run. This hoodie features Phillies lettering and logo embroidered on the front and an unfinished hem line for a cool vintage look. You can also carry your phone and wallet—or just keep your hands warm—in the front pouch pocket. You'll be sporting Phillies spirit with an extra burst of awesomeness in your warm outfit!
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text:
Watch it here!
September 5, 2008
Got Another 5 Minutes?
Watch it here!
24 comments:
ooooh Steph, I loved it, and you looked so cute on camera!! I hope I look sorta cute too when I try doing a vlog here in a few weeks for newbaby.com....Ill let you know when I upload it! (and if it is horrible you HAVE to tell me so I can redo it) lol!!ReplyDelete
Awesome! And, definitely wishing you a smooth delivery :)ReplyDelete
Wishing you a smooth delivery. You looked cute in the video. Thanks for the great tips.ReplyDelete
Just watched it...you are so cute. :) And the roundness definitely didn't distract, it just adds to the charm. So excited for you, praying for a safe delivery.ReplyDelete
just watched the video and i loved all the advice you gave. hope you have a smooth delivery with the new baby.ReplyDelete
Your just adorable and you look radian in the interview!!!! How are you feeling?ReplyDelete
You looked great! Nice interview and I love how genuine you are.ReplyDelete
Hope you're feeling well. Can't wait to see that baby!!!
Just watched your video. You look great as always. Hope you made it trhrough the day without Ivy making her big debut!ReplyDelete
I just watched the video and my daughter is sitting on my lap. She kept saying "More! Baby! Belly!" So we had to come back to your site to check out the baby in your belly! She still keeps asking for more!ReplyDelete
Just watched you... I would love to have as many people who comment on your post. How fun to be able to meet so many new "people".ReplyDelete
Can't wait to see pictures of that little lady:D
loved the video. you are darling & had such wonderful tips. good luck on your delivery... i know it will go great!ReplyDelete
you look great, and you are such a sweetie!ReplyDelete
I agree- You come off as so sweet and genuine, definitely that girl that everyone wants to be friends with!ReplyDelete
I watched it!! And you look gorgeous as usual! :) I can't wait to meet your baby girl verrrrry soon!!ReplyDelete
You look great! I wish I looked that cute pregnant. I just look like the Goodyear blimp! I hope your head feels better soon. -KatinaReplyDelete
Couldn't see the video, but congrats on the coming birth of your new little one. We are leaving on the 11th for our daughter in China (I emailed you a while ago about baby carriers for 18+lb. babies. I found the mei tai I had won!)ReplyDelete
Best for all of you - and may God grant you all health and joy in the transition to another one.
I guessed Ivy would come to see the full moon on the 15th...ReplyDelete
As always, great job! Your vitality and light comes shining through! Great ideas, great reminders--ReplyDelete
So glad you liked Mommy Math--you're getting up there with the numbers yourself, girly!!
It's true... you are everyone's bloggy friend Steph! Thanks for the tips and for just being you (belly and all!) ;-)ReplyDelete
You gave great info on responsible blogging for anyone just beginning as well as for anyone wanting to comment on someone's blog. This video should be required viewing by everyone who blogs!ReplyDelete
Distract? The roundness is WAY too cute to be distracting! I bet you would be so much fun to hang out with!ReplyDelete
I love seeing you in action, round or not.ReplyDelete
But I have to say, having recently been pregnant, I totally understand what you mean by the roundness. Last December, when I was 35 weeks pregnant, I was wearing a lot of maternity turtleneck sweaters -- and I hated how they made me look. I commented to a good friend that the only thing not swollen on me at that point was my collar bones and since the turtlenecks hid those ... "You've lost your skinny spot," she said knowingly. EXACTLY!
I watched the video and left a comment over there. I enjoyed it and you motivated me to get back into commenting! I used to do it all the time (way back, oh a month or so ago) but got distracted with some other bloggy business. I'm not going to neglect my friends any more!ReplyDelete
BTW, I'm in Lowell...
I learned a lot from this. Thank you so much. And congrats on that baby. Speedy recovery.ReplyDelete


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on March 19, 2013 - 1:08 AM
, updated March 19, 2013 at 1:27 AM
Dear Carolyn: Sibling D is going through some mental health and substance abuse challenges and is angry at my parents for their failures while we were growing up. We've discussed it, and I sympathize – I went through a long period of anger myself – but I've gotten over it without ever directly discussing it with them.
D is demanding an apology, and seems to believe that without one it will be impossible to get healthy.
I don't want to excuse or ignore my parents' failures, but demanding an apology under these circumstances feels like emotional blackmail. I have no reason to believe that my parents are the cause of D's problems or that it would make a difference if they apologized. Selfishly, I have no interest in revisiting my anger or in reopening what I thought was a closed issue for me.
D needs my support and I can't avoid my parents, so this will come up again. Any suggestions for how to handle it?
A: Ask him why, if he's so unhappy with your parents' handling of his past, he wants to put his whole future in their hands, too?
Ideally he'll understand this without explanation, but if he doesn't:
Tell him you'll stipulate to the errors your parents made. Even allow, for the sake of argument, that your parents' mistakes back then are directly responsible for his challenges now.
Agree that sincere apologies can be transformative.
Then explain the "but." By demanding one of your parents – and by putting his life or recovery or whatever else on hold till he gets it – he gives them control over his life. Again. And what if they died tomorrow; no health for him, ever?
I realize how hard it is to choose health when feeling wronged, with that awful sense you're letting the wrongdoers out of jail free. Your brother likely feels ready to wait in perpetuity for your parents to do their share of suffering.
Don't negate that feeling. Instead, try describing that choice in non-emotionally charged terms: He's waiting to be fed ambrosia – the apology – though he has no say in when he gets it, if ever. Meanwhile, there are bran flakes that he can serve himself at any time – as in, a decision to accept what he has and make the most of his life.
Almost everyone holds out for the ambrosia at least once, at least for a while, understandably.
You can't make him stop waiting any more than he can make your parents apologize, but you can understand. And as the brother who chose the bran, you can also attest to how much better you feel since you did.
Reach out to family
Dear Carolyn: I have a former client who I have just learned has midstage Alzheimer's. I worked for him and his extended family for over 20 years. We parted on friendly terms. I would love to see him and his family again, but I don't want to be an added burden on his wife. What should I do?
– Anonymous
A: Send the wife a note or, even better given the ease of responding, an email. Such low-obligation contact is an emotional lifesaver for people dealing with a major illness. Plus, her response will likely tell you whether a visit would be a blessing or a chore.


text:
Expanding Use of NGS Has Largely...
Adapting to Evolving Business Environments Is...
As Immunotherapy Revolutionizes the Cancer Treatment...
LC-MS Gains Favor Due To the...
New approaches to scaleup and methods for overcoming issues that may impact or impair scaleup were two key subjects discussed at the recent Sartorius Stedim Biotech "European Upstream and Downstream Technology Forum."
Topics covered included both single-use and steel production systems, but the former led to a lot of discussion based on the increasing application of single-use systems in biomanufacturing activities. For example, even though a growing number of bioprocessors are turning to single use, techniques are still being developed for successful bioproduct transfer and optimization with these instruments.
"We successfully transferred and optimized a fed-batch process with CHO cell lines expressing a recombinant protein at high yield to single-use bioreactors at the 50 L scale," reported Anne Gilbert, Ph.D., deputy director for upstream processing at Novasep.
According to Dr. Gilbert, the cell optimization process was carried out using a stringent medium, which was then enriched during several feeds for the production step. The challenge was to transfer and optimize the costs and the production yield without increasing the medium and feed expenses.
"We succeeded in this effort by using the Biostat® STR single-use bioreactor," Dr. Gilbert explained. "The bioreactor geometry, the shear stress, and the dissolved O2 and CO2 distribution of this system are suitable for the cell amplification for this process, resulting in improved cell growth compared to stainless-steel bioreactors."
Dr. Gilbert's team currently employs single-use bioreactors with an extensive array of production systems, including mammalian, insect, and bacterial cells for multiple types of products, such as viral vectors and recombinant proteins. These operations are commonly carried out using the 50 and 1,000 L single-use bioreactors and, for some specialty activities, single-use bags up to 3,000 L.
One of the main challenges for single-use bioreactor users is scalability and transfer when you need to go from disposable systems to traditional stainless-steel cultivation technologies. This was addressed by Rüdiger Heidemann, Ph.D., senior staff development scientist, Christopher Cruz, senior associate development scientist, both of whom work at Bayer Healthcare on antibody development.
According to the scientists, an important factor in comparing single-use and multiple- use bioreactor technologies is the frequency with which production will be switched from one cell line to another. This is a relatively new area of endeavor for the company's Berkeley, CA-based site. The facility is currently committed to producing a recombinant antihemophilic Factor VIII therapy for the treatment of hemophilia A patients.
In preparation for their move into antibody production, Cruz and his colleagues have been comparing single-use bioreactors commonly employed during early process development with reusable stainless steel and/or glass vessels. Their research program aims to improve processing using fed-batch and perfusion technologies.
"For stable molecules, such as monoclonal antibodies, we favor fed-batch technology. That is where we currently implement the single-use bioreactors," said Dr. Heidemann. "But for our perfusion platform, we employ stainless-steel vessels as the preferred option."
Given that the company currently has a full antibody pipeline, Dr. Heidemann is looking for a quick product changeover, obtainable with disposables.
"We really have to distinguish 1,000 L and 2,000 L production levels for clinical manufacturing," he continued. "But with commercial demands that may go up to ton quantities, we would probably use stainless steel. We do not foresee that in the near future disposables will be able to handle large commercial volumes, unless the market demand would allow smaller batch sizes"
According to Cruz, neither approach is 100% secure. "Disposables tend to have a higher failure rate as they are subject to shipping and handling issues. If the bag fails, it sets you back, so we have to make sure it is as intact as possible," Cruz explained. "Of course, stainless-steel vessels can fail, too, for example, due to defective or improperly installed gaskets or clamp connections, or any other operational mishaps."
Gerhard Greller, Ph.D., R&D director for upstream technology at Sartorius Stedim Biotech, focused on the optimization of single-use bioreactors. With the widespread adoption of single-use systems, the problem of leachables from the materials used to construct the plastic is becoming more significant.
"If you are ordering 50 L of media at a time, you may need to store it for weeks," explained Dr. Greller. "That means these substances can drastically affect the growth of cells."
Dr. Greller and his team have identified many of these compounds and redesigned the film that lines the bag. "We had to start from the resin selection. Through this approach, we went through a rapid learning curve, allowing us to characterize the leachables, including materials released by the gamma-irradiation process."
Dr. Greller mentioned the work of Matthew Hammond and his coworkers at Amgen, who have identified one of the most toxic extractable compounds from a number of substances present in the polymer films used in presterilized, single-use biomanufacturing systems.
This molecule, bDtBPP, is detrimental to the growth of a number of strains of CHO cell lines, even at concentrations as low as 100 µg/L. It is derived from the compound tris(2,4-di-tert-butylphenyl)phosphate, and affects the mitochondrial membrane potential. Ionizing radiation, used in the sterilization process, appears to be the mechanism by which bDtBPP is generated.
Another critical quality control issue emphasized by Dr. Greller is the monitoring of leakage through suitable testing programs. The test method must effectively identify potential damage to installed bioreactor bags, including the bag seals, port welds, connections, and bag surfaces, which could be damaged during their assembly. These failures could cause substantial financial losses as well as constituting a significant safety hazard.
To deal expeditiously with the need for effective leak monitoring, Dr. Geller's colleague, Martin Dahlberg, uses the Sartocheck®4 Plus Bag tester with a bag-tester fleece that prevents masking of any leaks that may have been introduced during installation.
"It allows point-of-use leak testing of single-use bioreactor bags post-installation and pre-use in its final bag holder," said Dr. Geller.
The goal of these advances is to ensure the end user does not have to touch the bag and accessory components any more than necessary."
The broad adoption of single-use technology presents particular opportunities for protein production in continuous culture of mammalian cells, especially as companies prepare for the move to scaleup. According to Christel Fenge, Ph.D., production specialist at Sartorius Stedim Biotech, nutrients may be delivered by perfusion culture or concentrated fed-batch mode operation.
"With continuous culture we can maintain higher cell densities and higher titers in a stable environment, but the process is more complex," Dr. Fenge stated. "As a result, this is a more demanding protocol that runs a higher risk of failure and calls for higher training requirements for personnel."
But can single-use bioreactors measure up to the challenges of such conditions? Dr. Fenge and her coworkers have grappled with the needs of high O2 demands, sufficient CO2 removal, long operating times, and elimination of proteinaceous aerosol formations.
They determined that the best oxygen transfer was achieved with a microsparger and Rushton marine impeller combination. Effective CO2 partial pressure control was achieved using a microsparger in a 50 L program at a high cell density. Effective off-gas treatment was performed with a single-use exhaust cooler, a component of the Biostat single-use bioreactor.
According to Dr. Fenge, perfusion is the most suitable approach for labile or difficult-to-express products. It can reduce process development time, provide a more stable environment, and perform efficiently in smaller production bioreactors, and it requires fewer seed steps.
"We have found that perfusion fits well into the current biopharma trends," Dr. Fenge said. "It adapts well to production of biosimilars, the expression of new monoclonal antibody formats, and the need for smaller production quantities."
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When I was in the Army during the Vietnam War, the noncoms would ask me what three things does it take to fight a war.
At first I said the Army, the Navy and Air Force. They said no it takes money, money and more money!
For a while, I didn't think about it much, but I've always had a curious mind. So, I did some research and found out that the stockholders of the military industrial complex got all that money.
Now we're engaged in another war and just stepped out of a second.
You hear about all these soldiers getting killed or maimed - arms and legs missing, blinded or disfigured both physically and mentally.
To some in this country, that's OK as long as their capital gains and dividend money keeps flowing in.
These billionaires' sons and daughters will never go in the military. Their rich daddies can buy them a diploma at one of the diploma factories like Princeton, Cambridge and Harvard.
President George W. Bush gave them a tax of 14 percent on top of the money they're making from the wars.
These are real patriots making money from our poor soldiers. Then they cry that they shouldn't have to pay the same tax rate as the working peasants.
Also, all this money was borrowed from the communists in China.
William C. Green


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Hague Bests 54-Hole Record, Takes Second at Jim West
NEW BRAUNFELS, Texas -- Jenna Hague tied for second with the best 54-hole score in school history and the Ball State women's golf team finished in sixth place Tuesday at the Jim West Challenge.
Hague carded a 1-under par 70 in her final round to end the tournament with a 1-over total of 214. She held at least a share of the lead for nearly the entire day, but Gonzaga's Raychelle Santos birdied two of her final five holes to win by two shots.
Gonzaga also finished atop the team leaderboard, holding onto its overnight lead and posting a three-round total of 878 (+26). The Bulldogs were eight shots clear of second-place Texas State, the tournament host, in the field of 15 teams.
Ball State seniors Meghan Perry, Sarah Westaway and Mary Welch each shot 77 to provide the team's other counting scores Tuesday. The Cardinals turned in their best team score of the week with a 301 to climb one spot on the final leaderboard and finish with a 54-hole total of 926.
Hague was steady all day on the par 71, 6,178-yard layout at The Bandit Club, recording 15 pars and two birdies to just one bogey. The 72nd-ranked player in the country finished in a three-way tie for second with overnight leader Ciera Min of Gonzaga and Iman Nordin of Texas State. It was Hague's eighth straight top-10 result.
Her 54-hole total of 214 broke the previous school record of 215 that she shared with Brittany Kelly. Hague and Kelly continue to share the record for best 54-hole score in relation to par with each of their previous 215 scores coming in 1-under finishes.
Perry, Westaway and sophomore Karley Dobis each ended the tournament with identical scores of 240 (+27) to tie for 44th place for the week. Welch rounded out the lineup at 247.
This week's tournament was the first of the spring season for Ball State and included 11 teams ranked among the top 150 in the Golfstat rankings.
The Cardinals will return to action March 7-9 with the Rio Verde Collegiate Invitational. Western Michigan hosts the event in Rio Verde, Ariz.


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The army of dependable neighbors
March 6, 2012
Who would you turn to if you needed help? Someone who's dependable, resourceful and willing to go the extra mile? Salvation Army volunteers from Randolph County were honored Saturday for being just......
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Green Energy's Top Foe: Other Greens
Editor's Note: Randy T. Simmons, one of the authors of the article below, is a professor at the Jon M. Huntsman School of Business.
The New York Post
By RANDY T. SIMMONS & RYAN M. YONK
"Think globally, act locally": Amazingly often, that principle leaves the environmental movement fighting environmental projects. And a major case of it may be coming soon to New York.
Indeed, New York City's already gotten a taste of it: Just last year, Park Slope residents leveraged environmental-review requirements to sue the city to remove bike lanes by Prospect Park.
Enough copycat lawsuits could mean big bills for the city: In 2006, an environmental suit against San Francisco's bike-lane plan kicked off a five-year legal battle that cost the city over $1 million; the project didn't move ahead until it had produced a 2,000-plus page environmental review.
And the problem is far, far worse when it comes to green energy projects.
To read the complete story, click here.


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Gray had woken up on the wrong side of the bed yet again and there was a whole lot of stomping and screaming at the top of the stairs.
No matter how determined I may be to assure myself that this day, any day will be a good day, it hinges on the personalities and moods of several other people in my immediate vicinity.
Head in my hands, I thought- and not in a kidding way at all but totally serious- what would Jesus do?
I calmly walked up the stairs with my arms outstretched. He continued to scream. Even louder. I reached out to him and he ran away.
I sweetly asked him to please come see Mommy. He tried to hide under a chair.
It began to hurt a little, his running from me when all I wanted to do was hold him. I decided I wouldn't wait for him to come to me and so I went and picked him up myself.
Tears and struggle and skin and bones and finally he gave in to my embrace.
It's familiar. It stings.
And finally I gave in to His embrace.
Subscribe to my blog here
Twitter me- I'm babysteph


text:
Finding the very first apartment for yourself may prove to be really exciting. It really sounds quite simple to go out there and look at different apartments, find the one that is up to your requirements and pay its rent. But that's not exactly like this. Finding Portland Oregon apartments for rent may prove to be exciting and fun but one needs to be really careful prior to handing over any money to the potential landlord. If you are a starter, you must decide the budget first. Will you be in need of any roommates and if that's the case then how many of them? The apartments will get pricier as you keep on increase the number of rooms you want in the apartment. Another thing to be decided is that whether some apartment complex is desirable for you or you want someone's home on rent...Read More
Renting apartments has always been a process that requires a lot of insight and proper research. If you are looking for portland oregon apartments for rent and haven't had much of luck on your side so far, you should take a look at the points mentioned here that will help you to get a perfect apartment for you.
Here are some important points for you to consider when renting an apartment in today's challenging market, no matter if you are looking for roommates or just a flying solo.
First of all, you need to be realistic when setting a budget. Conventionally, you'd be considered wise if you don't spend above 30% of the annual income of yours on the housing costs...Read More
A strange thing happened when someone invited his friend to his rented house for the whole night; he found out that his rent agreement has been terminated. Why? Because he violated its terms and conditions which we often skip reading before signing the rent agreement. It stated that you can't call over a friend of yours to the home without taking prior permission from the owner. This is a strange case of portland oregon apartments for rent which obviously shook the ones who were living in that apartment and they are now hunting for a new shelter. There are certain things which we skip asking before renting an apartment...Read More
Renting your first apartment can be an exciting task but it can easily eat up a lot of your time. It sounds ambitious and thrilling to go out and look for a perfect home but you can easily end up in a mess. You should be very careful before paying the lessor. Figure out how much budget can you afford to shell out on a monthly basis for paying your rent? How much do you need to sustain your family or inmates? Remember, more the number of rooms, more is the rent. Being a first one, you should ideally go for sharing basis as you will get the "know how" about these things and once it's done, you can easily move alone to a new rented apartment. When we do things which we haven't done before, we tend to commit mistakes and these mistakes can easily spoil the end result.
When you live o...Read More


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LAKE TAHOE - With a little less than a month to go before possible approval, the Tahoe Regional Planning Agency's Regional Plan Update has attracted widespread support - and stiff opposition.The sweeping plan, which will guide development in the Lake Tahoe Basin for years to come, has been under discussion for the better part of a decade and is expected to be in front of the TRPA's Governing Board for approval Dec. 12.About 65 people voiced support for the plan during meetings on both shores Wednesday and Thursday. Less than a dozen voiced opposition to the RPU during the meetings.Proponents contend regulations under the plan are a key step to moving the basin out of the perpetual state of disrepair and economic decline that has resulted from strict land use policies in place since the late 1980s, while also protecting the environment.The plan will provide the consistency needed by developers to make investments in the area, according to many business owners and operators."We need the RPU approved if we are going to move forward," Chuck Scharer, president and CEO of Edgewood Companies told the Governing Board.One of the major concepts in the plan is providing incentives to move development from sensitive land into existing urban areas designated as town centers.Such incentives are critical to redeveloping run-down properties that do little for the economy and harm the environment by creating stormwater runoff to the lake. Runoff from urban areas carrying fine sediment and algae-promoting nutrients has been identified as the major cause of Lake Tahoe's clarity loss.Ron Parson, with Granlibakken Conference Center & Lodge in Tahoe City, said the resort was among the properties that has suffered because of existing land use regulations. Unlike many though, Parson said the resort has also been able to stay the course and make improvements despite the rules.Like many who support the RPU, Parson acknowledged it's not a cure-all, but said it provides the incentives needed to promote environmental and economic improvements."I don't think this plan is perfect," Parson said. "I think we can move forward with it, and I think it's the right direction."Several people have said the plan represents a compromise between the often divergent interests at Lake Tahoe."Is this the perfect plan? No," said South Lake Tahoe City Councilman Tom Davis. "Is this everything the environmental community wants? Probably not. Is this everything the business community wants? Probably not. Is this workable? Yes. Is it time to pass it? You bet."Not everyone is convinced the plan is ready for passage. North Shore resident Dana Spencer said she is concerned the plan will allow a little too much height, a little too much coverage and a little too much urbanization. She urged the board to put the environment ahead of the economy."Tahoe is a beautiful place and should be protected first and foremost," Spencer said.Laurel Ames, with the Tahoe Area Sierra Club, has been critical of the plan, saying its concepts do not guarantee a cleaner lake and better environment. She told the board the RPU is "littered with loopholes and exceptions.""I think this plan turns many of the protections of the lake and natural resources on its head, and it's very disturbing," Ames said.TRPA spokesman Jeff Cowen said the concerns about overdevelopment are unfounded.Growth caps under the existing regional plan will remain in place under the RPU, Cowen said. The proposal also anticipates the population in the Lake Tahoe Basin's population in 2025 will be less than what it was in 2000, according to the TRPA spokesman.Although the plan calls for increased density in areas designated as town centers to increase alternative transportation like walking and biking, it will also increase the amount of open space found around Lake Tahoe, Cowen said.
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November 16, 2012
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UTSW shielded from whistleblowing surgeon's retaliation claim, state court rules
Dr. Larry Gentilello's lawyer called it a "last stop."
Nearly six years of court battles with his former employer, UT Southwestern, had triggered a federal billing-fraud probe that settled for $1.4 million and helped bring scrutiny to patient safety failures at Parkland Memorial, the medical school's teaching hospital.
But one bit of unfinished business remained. The trauma surgeon sought damages in state court over his 2007 demotion. That was, he said, an act of retaliation after he had blown the whistle to his department chairman.
On Monday, Gentilello's bid was dealt a blow when an appeals court ruled that a powerful legal shield enjoyed by state agencies protected UTSW against this case as well.
The 5th District Court of Appeals in Dallas sided with a lower court in arriving at its decision. It did not delve into the substance of Gentilello's billing fraud allegations. Instead it addressed whether the case could proceed in light of the sovereign immunity doctrine. (The opinion is at end of this post.)


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Below are current clinical trials.
Filter this list of studies by location, status and more.
Rochester, Minn.
Describes the nature of a clinical study. Types include:
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
The aim of this study is to evaluate efficacy and safety of riluzole in the treatment of patients with acute SCI. The primary objective is to evaluate the superiority of riluzole, at a dose of 2 x 100 mg the first 24 hours followed by 2 x 50 mg for the following 13 days after injury, as compared to placebo, in change between 180 days and baseline in motor outcomes as measured by International Standards for Neurological Classification of Spinal Cord Injury Examination (ISNCSCI) Motor Score, in patients with acute traumatic SCI, presenting to the hospital less than 12 hours after injury. Secondary objectives are to evaluate the effects of riluzole on overall neurologic recovery, sensory recovery, functional outcomes, quality of life outcomes, health utilities, mortality, and adverse events. The working hypothesis is that the riluzole treated subjects will experience superior motor, sensory, functional, and quality of life outcomes as compared to those receiving placebo, with an acceptable safety profile.
Study statuses change often. Please contact us for help.
Open for enrollment
CSM (Cervical spondylotic myelopathy) is the most common cause of spinal cord injury worldwide. While there is evidence from the recently completed SpineNet prospective study that surgical decompression is an effective treatment for CSM, it is clear that many patients have remaining neurological impairment. While surgery is relatively safe, approximately 3% of patients maintain a neurological problem. Given this background and data from preclinical models of non-traumatic and traumatic spinal cord injury, there is strong evidence to consider the potential benefit of adding a neuroprotective drug which aids in the treatment of patients with CSM whom are undergoing surgical decompression. Riluzole is FDA-approved for the treatment of amyotrophic lateral sclerosis, which has some similar clinical features to CSM. Riluzole is currently under investigation for traumatic spinal cord injury. Given this background, there is a strong basis to consider studying the potential neurological benefits of Riluzole as a treatment to surgical decompression in patients with CSM.
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Product Details
Sets up in seconds.
The convenience of an umbrella meets the control of a softbox. Built on an umbrella frame, the Halo light modifiers set up in seconds.
Perfect for on location, home studio, or studio on the go.
No additional parts, no need for a speedring, and no extra pieces to lug around. The Halo series takes simplicity to a whole new level. opening up just like an umbrella and set up in seconds making them perfect for any on-location photographer.
No adapter ring required.
Most softboxes require expensive and heavy adapter rings to properly set up. Built on an umbrella frame, these units simply pop open like an umbrella and fit into the umbrella receptacle found on virtually all style studio lights.
Perfectly paired with speedlites.
The Halo light modifier is a perfect pair with speedlites offering soft box control with the set up ease of an umbrella. An optional 5015 Shoe Mount bracket is required to mount the speedlite and Halo onto a light stand with full tilting capability.
Fits virtually all studio lights.
No need for an adapter ring as virtually all style studio lights come standard with an umbrella receptacle to attach the Halo light modifier.
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Perfect for photographing large groups or children, the Halo light modifiers offer over 140-degrees of light spread. You get the broad light source effect of an umbrella, while maintaining the light control of a softbox.
For use with mono lights.
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Specular highlights.
Face the light forward through the white diffusion front for specular highlights. Specular highlights will provide a "hot spot" on your subject with a greater fall off from highlights to shadows.
Product Specifications
|1 Year
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|Item Length:
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on December 5, 2012 - 11:29 PM
Eight more low-performing Buffalo schools will be submitting improvement plans in January using the least-dramatic of four federal models, district officials told the School Board on Wednesday.
One other low-performing school will submit an application that involves hiring an outside group to run it.
The improvement plans for those nine schools are in addition to plans that are already in the works for another 12 low-performing schools.
But it's questionable whether the state Education Department will even consider the district's grant application for the nine schools – regardless of what model is used – because of the impasse with the teachers union over teacher evaluations.
The district must submit improvement plans for nine more schools by Jan. 25, officials said. But if the district does not have an approved teacher evaluation plan in place by Gov. Andrew M. Cuomo's Jan. 17 deadline, the state Education Department will not even consider those grant applications, they said.
"It's the potential to not have access to up to $18 million for our lowest-performing schools," said Debra Sykes, associate superintendent.
Each school is eligible for up to $2 million a year for three years in federal improvement grants, although the state generally has been awarding less than the maximum amount to schools.
That potential $18 million in forgone grant funding is in addition to $33.4 million in districtwide state aid the Buffalo schools stand to lose if they miss Cuomo's deadline for having an approved teacher evaluation plan.
The district has four federal improvement models to choose from for its low-performing schools.
One option would be closing a school – not considered a viable option in Buffalo, because those students would still need seats somewhere in the district.
Another option is known as the turnaround model, which involves replacing half the teachers.
The district and the union are currently involved in a court battle over the involuntary transfer of 51 teachers this year – making that model a nonstarter for plans for next year, Sykes said.
"It wouldn't make sense to try to do a turnaround, given the current case," she said.
The other two federal models are known as "restart," which involves hiring an outside group to run a school; and "transformation," which involves making changes that are considered less dramatic than replacing half the staff or hiring another entity to run the building.
The district currently is using the transformation model at Burgard, Bennett, South Park and Riverside high schools; International School 45; and Dr. Martin Luther King Jr. Multicultural Institute.
In the past year, the state has identified 16 more Buffalo schools as chronically low-performing. Albany is requiring Buffalo to submit improvement plans for nine of them for 2013-14; the remaining seven must submit plans for the following year.
The district can use the transformation model for no more than eight of the 16, under federal regulations.
Superintendent Pamela C. Brown on Wednesday declined to release the names of the nine schools that would submit improvement plans for 2013-14. She said she would release the schools' names at next week's School Board meeting.
District officials will choose the nine schools from these 16: BUILD Academy; Makowski Early Childhood Center; Herman Badillo Community School; Waterfront Elementary; School 17; Hamlin Park Elementary; Highgate Heights; Harvey Austin; Harriet Ross Tubman; International Prep; West Hertel Elementary; North Park Academy; McKinley High School; Frank Sedita School; D'Youville-Porter Campus and Dr. Lydia T. Wright School.
email: email@example.com


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Heifer timed A.I. may benefit average heat detectors
by Jeff Stevenson
The author is a professor of animal sciences at Kansas State University, Manhattan.
At the 2009 Dairy Cattle Reproduction Council meetings, Albert De Vries and David Galligan teamed up to describe the economic principles behind timed A.I. programs. In this column, we will look at the concepts that apply to heifer breeding programs and their relative costs.
The most commonly used A.I. breeding program for dairy heifers involves estrus detection. Heifers generally show very good heats and are easily detected if daily observations are made by astute observers. A reproductive program is a sequence of insemination opportunities. Each opportunity affects the cost of the breeding program and consists of four factors: (1) costs for drugs, semen, and labor; (2) days from start of breeding (enrollment in a synchronization program) to insemination; (3) fertility of each A.I. breeding; and (4) time between inseminations.
Some key assumptions
The number of days from breeding to conception (days open) depends on the timing of insemination and fertility. For heifers, the cost per day open includes the rearing cost at the end of pregnancy. If all heifers start the breeding program at the same age, then rearing costs until that time are not relevant. Rearing costs during pregnancy were assumed to be similar for any reproductive program.
De Vries and Galligan examined the costs of four different heifer A.I. programs. These protocols are illustrated in the figure (adapted from Stevenson et al., 2008). The first two programs are based solely on heat detection (Control and PGF-HD); the third (HD-TAI) consists of a hybrid including both heat detection and timed A.I. The last program (G-TAI) involves timed A.I. with no heat detection.
The costs for each of the heifer A.I. programs are summarized in Table 1. Days to A.I. represent days from start of breeding (enrollment in the A.I. program) until A.I. occurred. Also shown are the conception after 28 days of the program and the drug and labor costs.
Total costs of the four reproductive programs for heifers were expressed as costs per pregnancy. The timed A.I. program costs per pregnancy were greater than for the heat detection programs in both the original analysis by the Idaho group (Stevenson et al., 2008) and spreadsheet analysis done by De Vries and Galligan (first two lines of Table 2, respectively).
The costs per pregnancy after A.I. program completion (line 3) were similar because all heifers were then inseminated based on signs of heat, and these costs are independent of the number of open heifers. The average cost per pregnancy for all heifers that conceived (comparisons among program costs in Line 4) was less variable for heifers that conceived at first A.I. This difference in cost per pregnancy applies to only heifers that conceived at first A.I., whereas the remaining heifers had a very similar cost per day open.
Comparing the results
Costs then were estimated comparing an all heat detection (control) program with those that applied one timed A.I. followed by all heat detection and A.I. (timed A.I. + HD).
Increasing rate of heat detection in the control program from 50 to 90 percent reduced the cost per pregnancy from $246 to $118, emphasizing the importance of heat detection.
In the timed A.I. + HD program, as conception of each A.I. rose from 45 to 65 percent, the cost per pregnancy fell from $153 to $106.
When conception was held constant at 55 percent, decreasing the days from start of breeding to A.I. from 15 to 5 days reduced cost per pregnancy from $142 to $115.
Holding constant conception per A.I. at 55 percent and days to first A.I. at 10 days, and raising the cost of drugs and labor from $10 to $20 resulted in a higher cost per pregnancy from $123 to $133.
The timed A.I. + HD program that required 10 days to first A.I., $15 for drugs and labor, assumed a 55 percent conception rate, and 21 days to the next insemination opportunity had a cost of $128 per pregnancy of which $28 was for semen, drugs, and labor.
When applying the control heat detection (70 percent) only program, the cost per pregnancy compared with the previous timed A.I. scenario was an additional $39. Thus, a control heat detection program needed to achieve 84 percent heat detection to generate a $128 cost per pregnancy of the one timed A.I. program.
If heat detection rate was 90 percent after the timed A.I. + HD option, the cost per pregnancy was $109. The control heat detection program needed to achieve 96 percent to generate the same cost per pregnancy. If the heat detection was only 50 percent after the timed A.I. + HD program, the cost rose to $169. The same cost was achieved for the control heat detection only program with only 69 percent detection. Thus, the timed A.I. + HD program allows for a lesser heat detection rate after first timed A.I. than a heat detection program with the same cost per pregnancy.
De Vries and Galligan concluded that timed A.I. programs in heifers can be profitable when conception and heat detection rates are average compared to industry standards.
What are your costs of breeding heifers? Can you reduce your heifer A.I. breeding costs? Happy A.I. breeding!


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Systemwide Events Calendar
SAPFB Spring 2014 Funding CycleSeptember 24, 2013 - October 6, 2013
Manoa Campus, Hem 220A
The Student Activity and Program Fee Board (SAPFB), one of six Chartered Student Organizations (CSOs) on campus, makes recommendations to the Vice Chancellor for Students bi-annually on the allocation of program fee monies that UHM students pay each semester. Recommendations are based on careful review and consideration of applications submitted to the SAPFB by interested parties to fund events and programs that benefit & enhance the UH Manoa community. SAPFB is excited to announce that it is currently accepting applications events and programs planned for Spring 2014. Applicants must be Registered Independent Organizations (RIOs), UH Manoa departments, or UH Manoa affiliated programs. To access the application or learn more about this opportunity, please visit the SAPFB website (please note the application is only available online): http://www.manoa.hawaii.edu/sapfb/
In the past SAPFB has provided support for the following types of expenses:
-Travel and lodging for guest speakers
-Musical bands/entertainment for campus events
-Printing of journals or informational newsletters
-Advertising and publicity for events
-Room rental fees in the Campus Center for exhibitions and showcases
-Food and drinks (non-alcoholic)
Applications must be submitted by 11:59 p.m. on Sunday, October 6, 2013. NO LATE APPLICATIONS WILL BE ACCEPTED.
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Peas and beans are easy to grow and great for children too. Sowing in succession (every few weeks) means you'll have a continuous crop throughout the summer. Try growing sweet peas next to your runner beans to improve pollination.
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Broad Bean 'Aquadulce Claudia'
Vicia faba, Fava Beans
A gardeners' favourite. Broad bean 'Aquadulce Claudia' is the best broad bean for autumn sowing, overwintering plants on the plot outside, for an early harvest the following spring. Slender pods of 23cm (9") long, are full of succulent white seeded flavoursome beans. Height: 100cm (39"). Spread: 45cm (18").
Companion planting: Try growing broad beans with summer savory to help repel black bean aphids, a common pest of broad beans.
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Bittersweet goodbyes for volunteers in Tanzania
03 April 2007
by Danica Vucic
Arusha, Tanzania: Almost a bittersweet goodbye of sorts. Although I was only volunteering a month in Arusha, I felt I was at home with LOHADA. All of the volunteers, teachers and mamas were always there with a kind word for us volunteers and more importantly the children. I could see the love all around. It was a very important and wonderful feeling to be a part of that love and unity.
Although we all work together to be able to provide as best as we can for the children, it is always harder on the volunteers, as they are the ones who will eventually have to leave. It is inevitable. Which brings me to something I remember someone asking me. How do the children deal with people always entering into their lives and then exiting a short while later? My answer to that is simple. With gratitude. You see how thankful the children are with everyone and anyone that enters their life. No matter how small or how large of an impact you have made on their lives it was something. And they appreciate it wholeheartedly.
The children are quite resilient and strong when it comes to goodbyes. Perhaps it is because they are used to it. Or perhaps they are thankful they had an opportunity for a volunteer to come into their lives and be able to touch their soul. Perhaps they are thankful they could show a small part of the outside world how much help the children of Tanzania need. Whatever the case when goodbyes are presented to the children they take that opportunity to turn it into something special and joyous. A celebration rather than a goodbye.
They come parading with song and smiling faces. The children present you with a card they all took time to draw and write in just for you. They give you hugs and kisses with such love and admiration in their eyes. To them you have just made their life richer. And they are sad to see you go but are grateful for you having been there.
And that really is the key point in any volunteer's experience. They were there. They saw. They helped. They will spread the word. They will return one day. I know I plan to. The children have enriched my life and I have done the same in return. We are connected over the oceans and they will always be in my heart. As I'm sure they will have me in theirs.
I think the best experience anyone can have is to volunteer. To give of yourself completely without wanting anything in return. That's what everyone at LOHADA does. And I am sad to have left but I am glad to be able to say I was there.


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Champion ice skater Katie Scarbrough has revealed the heartbreaking moment she told her two young children that she has just weeks left to live.
Champion ice skater Katie Scarbrough has revealed the heartbreaking moment she told her two young children that she has just weeks left to live.
Oh, that is so sad. For a parent to have to tell her children that she must leave them....
Although, they are a bit slow on it, as I posted the story on this forum on Thursday!
If you go into the thread in which I have been posting about Katie's cancer battle, you can find that message, which includes a direct link to Katie's blog post about telling the children.
But, it is not all doom and gloom. Since the blog post, Katie and the family went on a day out to the beach at Weston-super-Mare, Somerset. Her husband, Stuart, posted some photos of it on Facebook on Saturday. And, I have to say, although she did look frail, overall she looked a lot better than I expected.
I'm not posting any links to any of the photos of the family, as I don't want to invade their privacy at this difficult time. But, here is a photo which I think you will find very touching:
Although she was understandably very upset when writing the blog post, it looks like Katie has decided to make the most of what time she has left, and enjoy it with her family.
Good on you, Katie!
Heartbreaking Very poignant photo.
Katie's story is so heartwrenching. I really admire the way she is handling her disease, her prognosis, and especially her honesty with her children.
I lost my mother to cancer, and it was heartbreaking for me... and I was nearly 40 when she was diagnosed. I can't imagine dealing with this as a child.
God bless her, her husband, and her children through the challenging days ahead.
If you're close to your mother, as you clearly were and I was, there's no age that's old enough. But for children to lose a mother is an extra heartbreak. I add my prayer to yours, TontoK.
So what those kiddies must be going through must be incredibly heartbreaking. My thoughts are particularly with them at this time.
a new thread so that it would be prominent), Katie died yesterday morning.
Since the sad news was revealed, there have been many tributes left on Katie's Facebook profile.
One of the tributes was another photo which was very poignant. So, since it was in this thread that we were talking about poignant photos, I have decided to put the link up here, rather than in the new thread (http://www.goldenskate.com/forum/showthread.php?40919).
When Katie was skating, she trained at the Dundonald Ice Bowl. So, one of her friends that Katie skated with went there yesterday, and made this tribute to Katie:
Very simple, but very poignant.
Katie might be gone, but the memories will remain.
I feel so sorry for her children. I lost my father when I was 11 and 54 years later I still miss him. Will keep them and her husband Stuart in my prayers.
I posted a thread in the Announcement section about a show in Columbus, OH to raise money for breast cancer research - Skate for Hope. If you are in the area of Columbus on June 15 you may want to attend and help raise money. What is especially touching about this show is that many young/old/elite/beginner skaters participate. The elite headliners are donating their appearances, but the other skaters raise money to donate to the show in order to appear. Many of these young skaters have been touched by cancer in their families. I hope no one is offended by this Announcement being in this thread. Just trying to bring more attention to a way to help beat this terrible disease.
It really is an evil disease that touches so many people, so anything that helps research into it is to be applauded.
Good luck with the show


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Michael Rawlinson has one of the toughest jobs in gaming. He's the general manager of ELSPA, the Entertainment and Leisure Software Publishers Association, which rules the roost over the games you play and the companies that make them. Not only is he faced with a government that's asking tough questions about how games are rated, but he's also got to defend the industry when the mass media start spouting sensationalist headlines about 'murder simulators'. And if that wasn't enough, he's also the bloke in charge of tackling video game piracy, too. Phew. We sat down with Michael to discuss all of that, as well as hear why gamers should write to your local MP telling them PEGI is a better choice for game ratings than the BBFC.
VideoGamer.com: The ratings system from a parents perspective is obviously very useful. But in the research you've conducted and others have conducted, how widely do parents actually pay attention to the ratings? How much influence do they really have?
Michael Rawlinson: I think that's one of our big issues. That's one of the reasons why I want to back PEGI actually. There's been talk about people knowing the BBFC, but all the evidence that I've seen says that when the parent sees the BBFC logo on a film they take note. So when it's an 18-rated film for violence or sex they say 'oh I'm not letting Jonny watch that as a teenager'. But when they see that logo on a box relative to a game they say 'oh it's only a game I'm sure it can't be that bad'. So they may recognise the logo but their attitude to that logo in the context of the game and all of the brand values and all of the reassurance that a BBFC logo brings in respect to a film gets thrown out of the window when it comes to a game. So we actually think that the government backing PEGI and at the same time PEGI entering into a phase of consumer awareness, and let's be honest we need to tell parents that games are not just for children, we need to get that message across, and we can do that by saying this PEGI logo means this is a game. A game is not just for children therefore take note of the age rating. We've got to find sensitive ways in which to tell them what sort of content is in adult games because for some of them they don't have that experience and they have no idea what a game looks like. You ask a parent what might an adult film contain and they would start to reel off a whole list, gross violence, there will be sex in there, they'll have ideas of what an adult rated film looks like. If you ask them what an adult rated game looks like they may even question whether this is such a thing as an adult rated game, except they might think about Manhunt or GTA that they've read a little about in the papers.
We do need to contextualise it though, that less than three per cent of the output in terms of titles is adult in any given years. In terms of sales through the high street it was about six per cent. In the context of that we shouldn't overplay it; on the other hand we do need parents to take note. It's a time thing. In another five, ten years we won't have this problem because the adults will have been gamers and will still be gamers. I can see the situation where the parents during the day time and the early evening will be playing with their children appropriate games but at the same time when the adult's clamouring for that other product the father or the mother will be saying no, when you've gone to bed mummy and daddy will be playing that game, when you're older you'll be able to play it. So those conversations will begin to happen as the generations move on but at the moment we need to help them.
VideoGamer.com: Is it just a case of getting on GMTV and preaching the message?
MR: Well we were on GMTV. I was on GMTV last Thursday morning. Interestingly I had John Stapleton telling me how dreadful GTA was and how appalled he was that his young teenage son was playing it. Well you're the parent you stop him. It's rated 18 we didn't make you buy it for him.
VideoGamer.com: Did you say that to him?
MR: I didn't quite say that to him.
VideoGamer.com: You should have!
MR: I should have said it but then that would have been rather rude. But I did say it's rated 18 by the BBFC and parents need to take note of it.
VideoGamer.com: Case in point then.
MR: Case in point. Right in front of me. Maybe the BBFC isn't working, I said something like that. But we've got to use lots of different avenues. When we advertise the product, whether that be on television, in print, on the web, highlight the age rating. We've got to make sure it's clear and bold enough. And we do that. We've got to make sure there's information in the store, so when people are buying the products there are leaflets to be handed out, there are posters explaining it and the staff can be knowledgeable and communicate that to parents. I think that's happening and a lot of the store staff are getting that kick back from the parent, it'll be all right for Johnny he's old enough to play it, they're not listening. There's a myriad of ways and I'm not a marketer but what I do know is our industry is full of very clever people that market products. We only need to look at what's happened with the Wii and the DS over the last couple of years to change the way we play games. We've moved tremendously, and we've done that through PR and marketing. So we can do it on this. I'm absolutely convinced we can do it. We've got some broad ideas and we'll work with the industry and with government. The government has tremendous access to children and to parents. And we've got to use every opportunity we can and maybe there's some sort of snappy hard hitting campaign as we had with drink driving and with putting on your seatbelt, around child safety on the internet.
VideoGamer.com: Currently a 16-year-old for example might chance their arm and buy GTA from GAME or Gamestation, much like they would try and buy alcohol if they're the oldest looking person in their peer group. Currently it's a no lose situation for the person trying to do that. If they don't get sold the game nothing happens. But it's illegal to sell it. Should there be some kind of deterrent there?
MR: I think we have to get it into perspective that actually there are many things in this world that are not age appropriate for children. That runs from the youngest to the eldest child. In this country the age of adulthood starts at 18. Are all 18s mature and adult like? I'm not sure they are. But that's the line in the sand that as a society we've drawn. How daft is it you can get married at 16 but you can't buy a porn film until you're 18? You can be making your own at 16 but you can't watch someone else. So there are a lot of anomalies out there. So we shouldn't get too hung up around the edges. We need to set some clear guidelines. Tanya Byron recommended it be illegal to sell a game to someone not age appropriate under the age of 12. That can't be enforced. Because you've got to prove the offence, you've got to send someone under the age of 12 into the shop, mic'ed and wired for sound and vision to record that process but it's deemed inappropriate to use under 12 year-olds for test purchases, so you can't use the under 12 person to go and make the purchase so if you use someone who's over 12 to make the purchase they haven't committed an offence. So technically you've got issues prosecuting. But that doesn't mean it doesn't make sense to make it illegal to sell to someone under the age of 12 because it puts the shop keeper on their toes, it gives them the backing to say no, and they know the shop around the corner will also say no.


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Dan Ryan Builders Inc. to Andrew Lessard and Theresa Lessard, $249,900, Falling Waters
Dan Ryan Builders Inc. to Daniel Anderson, $208,499, Martinsburg
U.S. Bank, National Association to Alicia Hearn and William Hearn, $198,900, Falling Waters
U.S. National Association to Sam Newton, $109,400, Opequon
Jessica Hawbaker to Micah Parker, $140,000, Martinsburg
Dan Ryan Builders Inc. to Michael Shanks, $127,900, Martinsburg
HUB Acquisition Trust to Government Properties Income Trust LLC, $5,080,000, Falling Waters
Premier Development Inc. to Jull Clipp, $99,500, Mill Creek
Wanda Reid, Wanda Reid exec., Charles Reid, estate to Michael Bransfield and Roman Catholic Diocese of Wheeling-Charleston, $125,000, Martinsburg
L&M Builders Inc. to Darren Manspile and Alysa Becraft, $390,000, Falling Waters
Lawrence Rice and Violet Rice to Kevin Obitts, $75,000, Falling Waters
Seneca Trustees Inc. Sub Tr., Christopher Davis and Debbie Davis to Deutsche Bank National Trust Co., $191,250, Arden
Georgetown Square Inc. to Rachael Kime, $96,000, Martinsburg
Dan Ryan Builders Inc. to Richard Watson and Sandra Watson, $176,000, Hedgesville
William Baith Jr. and Brandi Baith to Ida Stanley, $115,000, Falling Waters
John Orem to Barbara McKenzie, $70,000, Martinsburg
Christopher Hallam to Luke Iwanowicz and Deborah Iwanowicz, $225,000, Gerrardstown
R. Vance Golden III Tr. to Paul Garrett and B.J. Garrett, $83,081, Gerrardstown
Barron Homes of West Virginia Inc. to Esther Hardy, $144,900, Arden
Deborah Cartwright and Deborah Iwanowicz to Jennie Rothwell, $140,000, Martinsburg
Jody Bennett to Londa Reynolds, $5,000, Martinsburg
National City Bank to David Funderburk and Lauren Hinchman, $163,000, Opequon
Gary Compton and Jeanette Compton to Pauline Gilbert, $209,873, Arden
Charles Maxwell and Ruby Maxwell to James Dillon and Laura Dillon, $13,700, Falling Waters
Richard Shockey and Eva Shockey to Susie McLucas and Daniel Dodson, $6,000, Falling Waters
Dan Ryan Builders Inc. to Joseph Phares and Wendy Anderson, $232,000, Mill Creek
Debra Reister to Lester Hathaway Jr., $155,000, Mill Creek
B&B Heating and Air Inc. to Berkeley County Emergency Ambulance Authority, $152,000, Arden
Kenneth Banks to Vanville Christian Church, $123,800, Arden
Richard Pill Tr. and George Brent to Jacob Johnson, $162,000, Martinsburg
Richard Pill Tr. and Rafael Pena Jr. to Deutsche Bank Trust Co. Americas, $175,000, Arden
Bancroft Investment Co. LLC Tr., Gregory M. Bancroft Inter Vivo S. Trust U/A to Jennifer Zigler, $140,950, Mill Creek
Richard Pill Sub Tr., David Pill Sub Tr. to Suntrust Bank, $229,415, Hedgesville
Philip Hereford Tr., Glen Mathes and Carolyn Mathes to Huntington National Bank, $219,889.37, Arden
Richard Pill Sub Tr., Sue Miller and Ricky Miller to American General Home Equity Inc., $60,000, Arden
Triple Crown Holdings LLC to Roland Keh and Kelly Keh, $70,000, Gerrardstown
Dan Ryan Builders Inc. to Charles Higgins and Paige Higgins, $138,300, Martinsburg
U.S. Bank N.A. Trustee to Kenny Bare and Sally Bare, $20,500, Falling Waters
Mitchell Feldman and Doreen Feldman to Siyavash Nejadi and Alicia Torres, $209,000, Hedgesville
Melvin Parra to Alex Hershaft, $150,000, Martinsburg
Flavio Parra to Alex Hershaft, $125,000, Martinsburg
Seneca Trustees Inc. Sub Tr., Brent Larson and Aaron Larson to Bank of America National Association, $182,750, Arden
Seneca Trustees Inc. Sub Tr., Kenneth Markle and Melinda Markle to Wells Fargo Bank N.A., $223,257, Arden
Deutsche Bank National Trust Co. to Stephen Hartman, $124,000, Opequon
Deutsch Bank National Trust Co. to Kevin Jackson, $215,000, Arden
Edgar Hargrave and Alison Hargrave to Gary Robertson and Tonya Roberston, $115,000, Mill Creek
Tucker Properties LLC to GLB LLC, $245,000, Martinsburg
Connie Kesner Sub Tr., John Smith and Mary Smith to Deutsche Bank National Trust Co., $342,000, Gerrardstown
Connie Kesner Sub Tr., Andrew Otchere and Akosua Otchere to Deutsche Bank National Trust Co., $52,500, Martinsburg
Connie Kesner Sub Tr., Deryl Dice and Heather Dice to U.S. Bank National Association, $113,380, Arden
Connie Kesner Sub Tr., Medeva Brown to U.S. Bank National Association, $127,875, Opequon
Charles Ashley and Rainell Ashley to Holly Alvaro and Sharon Alvaro, $115,000, Martinsburg
Deutsche Bank National Trust Co. to Jacob Keefauver and Nicole Smith, $124,900, Hedgesville
Jasper Properties Inc. to Brad Snyder, $112,000, Mill Creek
Martinsburg Ventures LLC to Richard Waddy and Julie Waddy, $325,240, Martinsburg
HSBC Bank USA to Shelly Agostinelli and John Washington, $167,000, Mill Creek
Bank of America National Association to Anthony D'Ottavio, $210,000, Martinsburg
Rebecca Ramsey exec., Beverly Malmstad estate to Christine Henry and Michael Henry, $122,500, Hedgesville
Dan Ryan Builders Inc. to Velda Brown and Larry Brown, $130,000, Martinsburg
Dan Ryan Builders Inc to Jack Gunter and Christy Gunter, $274,195, Martinsburg
R. Vance Golden III Tr., and James Tucker to Fifth Third Mortgage Co., $108,744.17, Gerrardstown
R. Vance Golden III Tr., James Lopez and Lelsey Lopez to National City Bank, $153,000, Martinsburg
Dan Ryan Builders Inc. to William Scott Jr. and Tabatha Scott, $135,000, Martinsburg
Tamara Clements to Joseph Licklider, $168,000, Hedgesville
Seneca Trustees Inc. Sub Tr., Chase Home Finance LLC, Pedro Modesto and Petronila Jose to Homesales Inc., $130,475, Mill Creek
Kathy Santa Barbara Suc Tr., Tracy B. Orr, Tracy A. Orr to Branch Banking & Trust Co., $129,365, Hedgesville
Dan Ryan Builders Inc. to Larry Taylor, $208,000, Martinsburg
Wells Fargo Bank NA to Randy Robson and Michelle Robson, $188,000, Mill Creek
Deutsche Bank National Trust Co. to Adam Mitchell, $104,900, Arden
Brett Morris and Amy Morris to David Hoffman and Priscilla Hoffman, $217,000, Falling Waters


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Former Gov. Mark Sanford formally jumped into the 1st Congressional District race Wednesday, saying he would tap into some of the more than $1.2 million in old campaign-account money he has at his disposal.
Meanwhile, Charleston County School Board member Elizabeth Moffly also has declared, bringing to 10 the number of declared candidates on the Republican side for the GOP-leaning seat.
While the field is one of the largest ever seen, Sanfords access to cash gives him a huge and early financial advantage in a fight thats expected to be dominated by the Charleston-area media market.
Sanford declined to identify himself as the early front-runner, other than to say he will hold to his early message of curbing spending in D.C and limited government.
Its a core belief and not a new-found idea, he said during an interview.
Sanfords recent Federal Election Commission campaign records show that from his time representing the 1st District previously, from 1995-2001, he still has around $122,000 cash on-hand. He could immediately use that money for a federal run.
Sanford also has more than $1,157,000 in his state-regulated gubernatorial campaign account. He could not use any of that money for a federal congressional bid unless he gets written permission from each donor.
I suspect Ill tap into some of that too, he said.
The race is already showing signs of being expensive. Former state Sen. John Kuhn, who announced earlier, said he was putting $250,000 of his own cash in.
Sanfords declaration comes as the dominant national story continues to be his political return after admitting to an affair with an Argentine woman during the last months of his second term as governor.
The event became a euphemism for adultery as Sanford reportedly said he was hiking the Appalachian Trail, when in fact he was in South America visiting her.
The Appalachian Trial gag continues to get play this political season as a handmade A over T sign was hung this week inside the former Tellis pharmacy in Charleston, which Sanford was considering renting as a campaign headquarters. He instead opted for space in Mount Pleasant.
He expected it wouldnt be the last of many hits he takes for his conduct, he said.
The woman, Maria Belen Chapur, is now his fiancee.
He did not know how visible she would during the campaign. Thats up to her, he said, adding that she is a very private person. Im going to respect what she wants to do.
The two-week filing period for the 1st District race opens Friday to fill the vacancy created with Gov. Nikki Haley picked former Rep. Tim Scott to fill the vacancy created when Jim DeMint resigned from the Senate.
Mofflys announcement is set for 11 a.m. today at 248 Magwood Lane in Mount Pleasant. She ran for state superintendent of education in 2010 and came in second to Mick Zais in the GOP nomination race. She will not step down from the board to run.


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In today's Points of Power Yolanda Adams and AV talk about having complete salvation through Jesus. Listen to the audio player as they discuss the first and second covenant and why we have complete access to salvation.
Get What You Missed From "The Yolanda Adams Morning Show" Right Here!
Get more Points Of Power here and listen LIVE weekdays at 9:45 am EST/8:45 am CST on "The Yolanda Adams Morning Show!"
RELATED: Points Of Power: You Can't Judge Others Salvation [EXCLUSIVE AUDIO]
RELATED: Points Of Power: Why Circumcision Has Nothing To Do With Salvation [EXCLUSIVE]
RELATED: Points Of Power: Everything We Need Is Found In Jesus [EXCLUSIVE AUDIO]
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On Thursday, while their castmates were partying after their Big Apple premiere at the Box on New York's Lower East Side, Pattinson and Stewart took a tour of the city's hotspots together.
The duo started their night at the ultra exclusive Soho House, where they "had a good time," a source tells PEOPLE. Later, they skipped over to Avenue, where they were spotted making out while their bodyguards tried to block prying eyes. The two also hung out with Joan Jett, who joined them at their table.
On Saturday night the two were spotted getting close at Dive Bar, on the Upper West Side – and they stayed out late. A source spotted the duo around 3 a.m. with their bodyguard in tow.
Finally, on Sunday, the two closed out their weekend with dinner at Megu in Tribeca. Pattinson dined on Kobe beef skewers and asparagus, while Stewart ordered a sashimi platter and the king crab. "They were with two friends and looked very cozy," says a source. "Both were having a great time."
See what other readers have to say about this story – or leave a comment of your own


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Thanks for joining us for our New Year's Eve Party!
This hour's topic is your New Year's resolutions.
What is your New Year's Resolution? Do you have one or a few? Or do you not believe in making them? If you have them, how do you plan on sticking to them?
This hour's prize is a $25.00 Amex gift card!
Every comment = a chance to win, so feel free to comment multiple times to keep the conversation. However, each entry must be unique (duplicate aka cut and pasted answers will not count as multiple entries.) We'll announce the winner at 9:00 pm ET!
Happy New Year's 2013!
U.S. Only. Employees of BabyCenter and their families are not eligible. The winners will be selected by picking a random comment number using random.org.