text:
Lota & Misty in the News
Richmond-area trainer finds home for 2 elephants (Northwest Herald, Aug. 3, 2004)
A McHenry County circus trainer has agreed to send two elephants to a sanctuary in Tennessee after being accused of animal neglect. (WXAD, July 30, 2004)
Lota the elephant could use some help (Journal Sentinel, June 23, 2004)
USDA Seizes Circus Elephants (Washington Post, March 18, 2004)
Government Seizes Elephant Herd (March 18, 2004)
Hawthorn Corporation Admits to Charges (USDA Press Release, March 17, 2004)
Elephant Owner Admits Guilt (March 15, 2004 edition of the Milwaukee Journal Sentinel)
Owner Agrees to Find Elephants New Homes (Chicago Tribune, March 8, 2004)
Trainer Cited in TB Case: Employees May Have Contracted it from Elephants
Elephant's Plight Recalls Bittersweet Tale of Ziggy (July 13, 2003)
Hawthorn Corporation has once again been cited (July 1, 2003)
Time to Let this Elephant Forget her Grim Past (Milwaukee Journal Sentinel, June 8, 2003)
Facility that Owns Lota the Elephant Faces Abuse Charges (Milwaukee Journal Sentinel, June 1, 2003)
SAVE 53 -YEAR -OLD ELEPHANT IN EMERGENCY CONDITION (April 20, 2003 petition update)
November 14, 2002 Update on Lota
October 11, 2001 Update on Lota
March 30, 1999 Update on Lota
July 13, 2003
I guess there is not a lot of "Lota" left. That is if you read an e-mail dispatched by a group trying to save a "sick, elderly circus elephant named Lota from Hawthorn Corp.," which trains and rents elephants to circuses.
The group, the Council for Lota's Retirement, describes Hawthorn as "a well-known abusive company owned by renowned Chicago businessman John F. Cuneo."
They claim Lota, who is now 53, was captured near a salt lick in India when she was a baby, lived alone in the Milwaukee County Zoo for 30 years, was released due to aggressive behavior, and then donated to Hawthorn and "beaten into a trailer when she fell and urinated blood."
Accusations flew that Lota was subsequently diagnosed with tuberculosis and severe weight loss resulting in hip and spine protrusions and forced to perform, although chronically ill.
Cuneo, who has been charged with violating the animal welfare act many times, has denied the charges. "This elephant is so nice and pretty and fat.... She's just slow. She's like an old lady, you know."
Of the animal rights groups' complaints: "It's so awful to say this stuff because it's so untrue. How can they say this stuff?"
But this isn't the first time I've encountered an elephant story or a story the size of an elephant.
The elephant's name was "Ziggy."
Ziggy's story caught fire: Children held parades and raised pennies, U.S. soldiers in Vietnam dispatched money, and billboards mushroomed along the expressways to free the jettisoned pet of legendary showman Flo Ziegfeld. Ziggy had been chained to a wall at the Brookfield Zoo for nearly three decades.
Ziggy became "Everyman"; the symbol of what was wrong with the world. Soldiers feeling trapped in a foreign country sent letters urging Ziggy's freedom from captivity; people who couldn't escape from the Vietnam War being waged in their living rooms sent money to build a special enclosure for Ziggy.
Everyone wanted in on the act. Dozens of newspaper stories later, Life magazine weighed in and did a spread on the pitiful pachyderm.
Like Ziggy, Lota is temperamental. Like Ziggy, Lota is an Asian elephant. Like Ziggy, Lota's temperament gave her handlers headaches. Ziggy, who had entertained Ziegfeld's grandchildren when he was a baby and then was shipped to a zoo when he was of no use, was punished for attacking his handler during his musk period by being chained to a wall at the Brookfield Zoo for 30 years.
Until I happened upon Ziggy on a visit during a day off in 1969. All you could see was Ziggy's rear end because he was chained backward. And the yellowed news story about Ziggy's rampage in 1939, displayed at the front of his cell, was an outrage.
Ziggy had stood in the back of a zoo cage for 30 years, swaying to the sound of children taunting him to do the one thing he couldn't--turn around.
It wasn't easy getting the story in the paper. "Elephants don't have feelings," said my editor. But once the story broke, all hell broke loose. More than $100,000 was raised to build a separate enclosure for Ziggy, and when he was freed, the press went wild. Click. Click. Pop. Pop. Headlines.
Stories have also been written about Lota, and at last peek, the Elephant Sanctuary in Tennessee is still offering to take the aging beast.
Sadly for Ziggy, freedom didn't last long. Once into his new enclosure, he espied a herd of female elephants next to his new home. Attempting to reach them, he lost his balance and fell into the moat separating them from his outdoor pen. Ziggy was hauled out . . . and never recovered. He died within days.
The animal lover in me believes Ziggy died happily without chains. The animal rescuer in me believes Lota needs a happy retirement in Tennessee.
And when I read that my old friend Tom Hollatz, a former newspaper copy and photo editor, died last week--I thought of Ziggy. Tom loved Ziggy's story and wrote a children's book about him.
Ziggy. Lota. Afghanistan. Iraq. Heck, life is a bummer without freedom. Especially if you're an elephant with a long memory.
Michael Sneed is seen at 5 p.m. Tuesdays and Fridays on WMAQ-Channel 5.
July 1, 2003
On July 1, 2003, following a complaint filed with the United States Department of Agriculture, inspectors found that The Hawthorn Corporation was not in compliance regarding shade for their elephants. The facility was cited under section 3.127 for failing to provide shade from direct sunlight during the middle of the day.
U.S. Representative for Illinois's 8th District, where John Cuneo resides and where Hawthorn Corp is located:
June 8, 2003
When Lota the elephant looks back on her life and ponders her biggest regret, I'm guessing it would be that she didn't run faster the first time she encountered human beings in the wilds of India.
If you're an elephant, spending your life in captivity would be like a New York socialite being forcibly moved to the middle of the jungle where they don't even take credit cards.
I'd be more likely to eat a meaty gyro on a pita than side with PETA on most of its causes, but the story of Lota puts me in touch with my inner animal rights activist.
Photo: Lota falls while being loaded onto a truck at the Milwaukee County Zoo in November 1990.
A recently filed federal complaint accuses the Illinois circus training farm that bought Lota from the zoo of abusing the elephant.
Now in her golden years, Lota is still being abused at the Illinois circus training farm where she was sent by the Milwaukee County Zoo in 1990, according to a federal complaint recently filed against the facility.
The saga dates all the way back to 1954 when Lota and another elephant were delivered to our zoo, then at Washington Park. The animals were 4 years old, still considered babies in pachyderm circles.
A heartwarming story in the newspaper from that time tells how hunters in India hid near a salt lick that attracted a herd of elephants. "With torches and shouts" they drove the herd into a stockade they had built nearby, and 18 elephants were captured.
Pennies and nickels tossed in a jar by Milwaukee children helped pay for the elephants. The two elephants led a parade up Vliet St. to their new home and 0.0000002% of the square feet they were used to back home in India.
A girl from West Allis won a contest by suggesting the name Lota, the word for a vessel used in India to hold water. Moat was the word Lota became more familiar with.
Young Lota was described by zookeepers as "full of tricks, always looking for trouble." Well, she found trouble, and it led to a career change of performing circus tricks.
That part of the story is well known. In 1990, the zoo decided that Lota was becoming too aggressive, probably from 36 years of dodging coins and looking out at people swinging one arm in front of their faces and doing their best elephant call impression. With great strife, she was loaded on a truck and for $1 handed over to Hawthorn Corp. of Richmond, Ill., with the understanding that she would be well treated.
But Lota learned that humans don't always tell the truth. She has spent the last 13 years traveling around the country as a circus performer. Let's just say the job doesn't come with much of a health plan. The Department of Agriculture found evidence that Lota has been plagued by tuberculosis and weight loss so severe that her spine and hip bones are protruding.
John Cuneo, who runs Hawthorn, has denied the charges and says his elephants are fat and happy. But animal lovers persist in their efforts to get Lota out of his clutches and into an elephant sanctuary in Tennessee.
Carol Buckley, director of that sanctuary, thinks Milwaukee County ought to get busy rescuing Lota. Even on a good day, the circus life is cruel for elephants, she said.
"If they wanted to do the right thing for this elephant, they would do it," she said.
The zoo got rid of all of its Asian elephants and has given the space to the black rhinos, so they don't want Lota back. County Executive Scott Walker said there's nothing the county can do for Lota.
Not a whole Lota love there.
Lota has kept her side of the bargain, even though she never agreed to the deal. She has educated and entertained three generations of children and adults alike.
She's old. She's tired. Give this poor animal a rest.
May 31, 2003
by Jackie Loohauis
The northern Illinois facility that owns Lota, a former Milwaukee County Zoo elephant who became an international poster pachyderm for animal rights, now faces revocation of its license because of dozens of federal allegations of abusing Lota and other elephants.
In 1990, the zoo donated Lota to owner John Cuneo; his company trains and rents elephant acts to circuses.
The 50-year-old Lota became famous in 1990 when the Milwaukee County Zoo, citing problems with her temperament and space limitations for keeping Asian elephants, donated Lota to Cuneo, whose Hawthorn Corp. trains and rents elephant acts to circuses.
Televised video footage of Lota's removal from the zoo showed her collapsing as she was forced into a truck. The footage and Lota's circus work caused an international outpouring of sympathy for her among animal rights advocates, including actors Alec Baldwin and Kim Basinger, and People for the Ethical Treatment of Animals.
Medical treatment an issue
The federal complaint filed in April includes allegations that in 2001 Cuneo and the Hawthorn Corp. "willfully violated" regulations by failing to have their attending veterinarian provide adequate veterinary care to their animals and that it specifically, "failed to obtain treatment for an Asian elephant (Lota) who was excessively thin with a protruding spine and hip bones."
The complaint goes on to claim that Cuneo and the Hawthorn Corp. "willfully violated the handling regulations by exhibiting an Asian elephant (Lota) under conditions that were inconsistent with its good health and well-being."
It also alleges that in 2001 Cuneo willfully violated regulations with other elephants.
Federal inspection reports show that Lota has had serious health problems, including tuberculosis.
An October 2001 report said that Lota was "very thin" and had a mass on her hip. A May 2002 report stated that "Lota was to gain an additional 500 pounds before going back out on the road." She had reportedly regained weight as of the last inspection last fall, according to the USDA.
Cuneo told the Journal Sentinel in a phone interview that Lota and the other elephants at the facility are now "so fat they look like dumplings."
Cuneo rejects claims that Lota has been mistreated over the years and says he plans to fight the attempt to revoke his license. He claims that the USDA and People for the Ethical Treatment of Animals "are now working hand-in-hand" against his facility.
He did say that one of the 47 counts in the USDA filing was true, a charge that one of the other elephants at the facility had suffered chemical burns. He blamed the incident on a worker who had accidentally burned one of the elephants with a chemical designed to treat fungal infections. He said the burns had since healed.
Previous investigations
The agriculture agency has investigated Hawthorn Corp. before. In 1998, the federal government fined Cuneo $60,000 and suspended his license over animal welfare act charges. In 1994, it fined Cuneo $12,500 when an elephant belonging to the Hawthorn Corp. rampaged through a crowd in Hawaii, killing one person
Lota's fate has been the subject of many battles between Cuneo and various animal advocates.
"The entire animal welfare community knows Lota very well," says Carol Buckley, executive director of The Elephant Sanctuary in Tennessee, which has repeatedly offered to take Lota. The Humane Society of the United States filed a federal lawsuit in 1992 in an unsuccessful attempt to reclaim Lota, claiming violation of the Endangered Species Act. In 1997, the Milwaukee County Board, spurred on by County Executive F. Thomas Ament, retained legal counsel to attempt to get Lota back, although the statute of limitations on the transfer had ended.
According to the Milwaukee County Zoo, which came under criticism for Lota's removal, her transfer to Cuneo was made on condition that the elephant never be forced to perform. But Lota has since performed regularly in traveling circuses.
Milwaukee County Zoo spokeswoman Jenny Diliberti says the zoo is not interested in reclaiming Lota, because the original problems with space and Lota's temperament "are still valid today."
May, 2003
The Council for the Retirement of Lota has written a Petition which the Elephant Sanctuary is pleased to post:
SAVE 53 -YEAR -OLD ELEPHANT IN EMERGENCY CONDITION Read Petition Sign Petition
Body of Petition:
In 1990, the Milwaukee Zoo was forced to release its elephants after overwhelming evidence of the zoo's egregious elephant abuse was exposed to the public. All of the zoo's elephants were retired to sanctuaries-EXCEPT LOTA.
Lota was prevented from being retired. "Despite a public outcry, the Milwaukee Zoo DONATED Lota to the Hawthorn Corporation. The 1990 publicized transport depicted 40-year-old Lota being beaten onto a trailer, falling and urinating blood." The U.S. Department of Agriculture (USDA) remained silent.
Although chronically ill, Hawthorn leased Lota to circuses. Like all circus animals, Lota traveled year round in unheated boxcars, deprived of water, food and ventilation - perpetually in chains and shackles. As a result of her deplorable life and living conditions, Lota contracted a human strain of tuberculosis and became severely emaciated.
Hawthorn Corporation is located in Richmond, Illinois. Hawthorn trains and leases elephant acts to circuses and facilities worldwide. For over a decade, the USDA has cited Hawthorn for failure to meet minimal federal standards for the care of animals used in exhibition as defined in the Animal Welfare Act (AWA). Hawthorn's litany of violations frequently relate to its gross "failure to provide veterinary care" and "physical abuse of elephants."
Hawthorn is continuously cited by the USDA and has accumulated $72,500 in USDA penalties. The USDA has twice suspended Hawthorn's license. Hawthorn has repeatedly failed to comply with prescribed tuberculosis treatment protocol.. As a result, four Hawthorn elephants have died from a human strain of tuberculosis. Despite decades of flagrant animal cruelty and negligence, the USDA has made no attempt to revoke Hawthorn's license.
LOTA IS NOW 53 YEARS OF AGE. She has been enslaved for her entire life. In June 2001, Lota traveled with Walker Bros. Circus. USDA documents state that Hawthorn was cited for "failure to provide veterinary care to Lota who was excessively thin, with a protruding spine and hip bones and sunken in eyes." The inspector wrote, "It appears that Lota has lost a significant amount of weight."
On October 11, 2001, the USDA reported that Lota was in a "perilously emaciated state, with a wound on her left hip." Lota's untreated wound, documented several months earlier, had "expanded into a large, painful, fluid-filled abscess that extended down to her mid-thigh. The property manager and trainer stated that they had never seen Lota so thin. Lota was in need of foot care and had not been weighed since 1997." In 1996, Lota contracted a human strain of tuberculosis from the numerous Hawthorn employees who tested positive for tuberculosis.
Hawthorn's elephant slaves are forced to endure the daily wanton brutality of Hawthorn trainers. They cannot escape their slave masters. In 1988, USDA documents described the torture of an elephant named Tyke who was performing in a circus act. While Tyke was performing, Hawthorn handler, John Caudill (a.k.a. John Walker of Walker Bros. Circus) "was observed beating the SINGLE-TUSK African elephant IN PUBLIC to the point (where) the elephant was screaming and bending down on three legs to avoid being hit. Even when the handler walked by the elephant after this, the elephant screamed and veered away, demonstrating fear from his presence." The USDA remained silent.
Lota also travels with Walker Bros. Circus. Given Caudill's brazen attitude regarding public beatings, what horrors are endured in secret by Lota and her companions? The answer can be found in John Caudill's monstrous cruelty to a Hawthorn elephant named Delhi. In 2002, the USDA reported that "Caudill soaked Delhi's feet in UNDILUTED FORMALDEHYDE causing severe chemical burns. Delhi was found in a serious health emergency. Both of her front legs were twice their normal size and were swollen up to her chest. She could not bend her front legs at the elbows, was reluctant to bear weight on her front legs and had difficulty in walking. The attending veterinarian did not respond in a timely manner."
In fact, circus fans have witnessed and protested the horrific sadism of Hawthorn trainers. In 2001, a letter to the Chicago Sun-Times editor described the wanton brutality endured by Hawthorn elephants leased to Medinah Shrine Circus. The letter read, "When the elephants were brought behind the curtain, the trainer began verbally abusing and hitting the elephant. We watched in horror as he swung a stick with all his force and struck the elephant in the back of the leg...the elephant let out a scream that could be heard throughout the UIC Pavilion. The kids were frightened and asked me why the man was hurting the elephant." The trainer was John Caudill. Yet, Caudill remains untouched by the USDA.
In January 1995, USDA documents state that Hawthorn trainer, "David Polke, instructed Michael Pursley to command Hattie to "lay down" (sic) and then beat Hattie with an ax handle." Gentle Hattie, gave rides to children until her death in 1996. Hattie died from untreated tuberculosis at the age of twenty-six.
"...[T]rainers also used water and food deprivation and electric shock from a cattle prod on the elephants. ...[H]e witnessed Tommy Thompson, manager at Cuneo's animal facility in Richmond, Illinois, shock (hot shock) an elephant repeatedly for one-half hour in order to get the elephant to lay down (sic) and get up upon voice commands."
The USDA cited Hawthorn for "physically abusing elephants" in June 2001. The Hawthorn handler was observed "gouging an elephant named Ronnie on the trunk with a bullhook, causing an open lesion. A different handler was observed raking the back of another elephant several times with his hook during the performance." Hawthorn trainers have never been charged with FELONY animal cruelty.Despite her advanced age, deteriorated state of health and years of endured brutality, the USDA has not seized Lota from Hawthorn. IN FACT, THE USDA HAS APPROVED 53-YEAR-OLD LOTA'S RETURN TO PERFORMANCE. In 2002, Lota was reported to be 700 pounds underweight. A 35-year-old Hawthorn elephant named Joyce was 1000 pounds underweight at the time of her death.
In flagrant disregard of Joyce's death and Lota's advanced age and perilous state of health, a veterinarian made the horrific decision to return Lota to the road.
Hawthorn continues to demonstrate an arrogant defiance of USDA directives and federal law. Nevertheless, the USDA has not revoked Hawthorn's license. This long history of USDA inaction is disgraceful and untenable.
John Cuneo, CEO of the Hawthorn Corporation, has rejected all offers to retire Lota to a sanctuary. In view of this, we wrote to ELLEN MOYER, THE MAYOR OF ANNAPOLIS, MARYLAND, asking for her assistance. Mayor Moyer wrote to Cuneo requesting the humane retirement of Lota. Several sanctuaries are willing to provide a permanent home for Lota.
We ask that you join Mayor Moyer in demanding the immediate and permanent retirement of Lota and the permanent revocation of Hawthorn's license.
Lota is worthless to Cuneo from a monetary and performance standpoint. MOREOVER, LOTA WAS DONATED TO CUNEO. By publicizing Lota's plight, we believe that Cuneo will realize that it is in his favor to release Lota. The strength of Mayor Moyer's request has started the momentum and we believe that Cuneo will release Lota based on a successful petition campaign.
If Lota is not currently traveling, she is warehoused in Hawthorn's compound in Richmond, Illinois. The facility has been cited by the USDA. IF LOTA IS NOT RETIRED IMMEDIATELY, SHE WILL CERTAINLY DIE. It would certainly be in Cuneo's favor to retire Lota - rather than for her to die at Hawthorn. Lota's death would create additionally bad publicity for Cuneo.
With proper medical care and a natural environment, Lota can still enjoy freedom (albeit man-made), companions and the security of a permanent home - all of which she has been denied.
Please assist us in securing this majestic individual's long overdue retirement. MORE THAN EVER, LOTA NEEDS YOUR HELP NOW.
After signing this petition, Contact John Cuneo. DEMAND THAT HE RETIRE LOTA NOW. TIME IS RUNNING OUT FOR 53-YEAR-OLD LOTA.
John Cuneo
Contact the U.S. Secretary of Agriculture and URGE HER TO SEIZE LOTA NOW AND IMMEDIATELY RETIRE HER TO A SANCTUARY. Urge Secretary Veneman to PERMANENTLY REVOKE HAWTHORN'S LICENSE. Your taxpayer dollars support the USDA.
The Honorable Ann M. Veneman
U.S. Representative for Illinois's 8th District, where John Cuneo resides and where Hawthorn Corp is located:
November 14, 2002 Update on Lota
a supporter recently reported....
Read your newsletter and called the USDA about Lota. Talked to Mr. Rogers yesterday (11/13) who told me that Lota was going to Florida. He mentioned a future article by Jackie Luhouse who writes for the Milwaukee Journal Sentinel. It is an in-depth study of Lota and her condition.
He called me again today (11/14) and said that things have changed. They decided to deny permission to transport Lota to Florida in order to avoid the stress that transporting her would cause. They also denied transport of another elephant there. Was extremely happy that the USDA seemed so responsive.
I hope this is all the best for Lota.
October 11, 2001 Update on Lota
The USDA is the sole Federal agency responsible for monitoring the welfare of performing elephants. Lota has been the subject of many inspection reports over the years. Her health problems began after her transfer from the Milwaukee Zoo to John Cuneo's Hawthorn Corporation, a company that rents elephants to circus. Lota's health deteriorated when she was sent on the road to perform in circus.
After losing hundreds of pounds and becoming increasing frail, she was finally diagnosed with the human strain of Tuberculosis, a non curable, life threatening disease. Lota spent nearly two years under treatment to control the disease and surprisingly was sent back on the road to travel and perform.
A recent USDA inspection report indicated that Lota is once again in very poor condition, again losing hundreds of pounds and has been returned to winter quarters. We will continue to monitor Lota's condition as much as is legally possible. But as long as she is considered a mere piece of property and her owner's neglect protected under the law, there is nothing the Elephant Sanctuary can do to help her.
The USDA report follows.
Negotiations have collapsed between Milwaukee County and Mr. Cuneo. After weeks of stalling, Mr. Cuneo surprised all parties concerned by informing Milwaukee County that he has changed his mind about returning Lota to their custody. After a full year of negotiations and planning Mr. Cuneo has reneged on his agreement to return Lota so that she can be retired to the Elephant Sanctuary. Legal action has not yet been taken by Milwaukee County against Mr. Cuneo in this latest turn of events.Lota Update:
In November of 1996, Lota and 15 other Hawthorn Corporation elephants were diagnosed with TB. The entire herd was sequestered and has been under treatment for the disease for the past year. Recently it was announced that all but 2 of the elephants were cleared by USDA for travel. Jim Rogers of USDA stated, "USDA never imposed quarantine on the Hawthorn elephants. Responding to the findings of attending veterinarians, USDA has released 16 of the 18 elephants for travel."


text:
a large amount ; several
dodane przez echoxofxdusk marzec 10, 2011
A group of too many people (or objects) up each others asses, while acting ignorantly.
When you are driving on the highway and can't pass others because there are 4-8 ignorant cars all blocking the highway, creating a clusterfuck.
dodane przez Lay Eggs luty 16, 2009
1) someone whos screwed up in a LOT of ways
2) a really complicated, bad situation
2) a really complicated, bad situation
1) wow. ive seen some screwed up people in my time, but she is a class A clusterfuck.
2) oh god this could turn into a bit of a clusterfuck if we dont do something now.
2) oh god this could turn into a bit of a clusterfuck if we dont do something now.
dodane przez PiixieLou październik 29, 2008
A drinking game where you get FUCKED UP.
You put a large pilsner glass in the center of a table, round table usually works best, you all "CLUSTER FUCK" which means you all put a little into the glass. Then you have people sit around the table and you try and bounce a ping pong ball into the cup. If you make it you pick someone to drink, but if you miss you pour a little into the cup and the next person shoots.
dodane przez Jamie Monks sierpień 14, 2007
(n) the management strategy and architecture utilized by the Edmonton Oilers. It relies heavily on incompetence and ego and downplays traditional values like accountability and heart. To be a true clusterfuck you must be completely devoid of foresight and oblivious to the present situation. You must only focus on successes of at least 25+ years ago as merit for any and all decisions made in the present day.
"Wow, I'm glad our NHL team isn't a clusterfuck like the Oilers."
dodane przez Poor Badger grudzień 03, 2014
When anything that can go wrong goes wrong. Imagine a tornado hits a sewage plant then travels and smacks the shit out of a fan emporium.
Holy shit! Getting from downtown was a total cluster fuck, there was sooo much traffic then a car flipped over, just to make matters worst two dudes started fighting in the middle of the street which soon turned to a mosh pit. Then some asshole ran into me and drug his car down the side of mine.
dodane przez The Keeper of Knowlegde czerwiec 05, 2014
the pattern of highway traffic where a small number of cars form a net or trap, slowing down other vehicles who are desparetely trying to escape
Sorry I was late, I was trapped in two clusterfucks on the way.
dodane przez Wigger P sierpień 20, 2012

subset: commoncrawl


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PITTSBURGH - Still trying to get over Sunday's debacle in Cleveland?
Better shake it off. The Pittsburgh Steelers play at Baltimore this Sunday, and that won't be easy. The Steelers had better shake off the Cleveland game, too.
That will be easier to do if they get Ben Roethlisberger back in the lineup. Coach Mike Tomlin reported that Roethlisberger did some throwing on Monday and might be able to play on Sunday.
In the meantime, the Steelers are preparing as though Charlie Batch will start. That undoubtedly makes some people cringe, and understandably so.
Batch was terrible on Sunday, but there are a couple of points that need to be made. Any team is in trouble if it's down to its third option at quarterback. Batch isn't very good, and that's why he had the spot on the depth chart that he did.
He's playing because two disabling injuries knocked out the first two choices at quarterback.
Beyond that, Batch didn't get much help in Cleveland. You know by now that fumbling was a four-man medley. There was also evidence that receivers ran poor routes. Little wonder that Heath Miller became Batch's favorite target. Miller's effort is always exemplary, regardless of the game situation.
The defense could have helped, too, by generating turnovers to gain better field position. Instead, nothing happened after Lawrence Timmons returned an interception for a touchdown in the opening minute.
Even if Roethlisberger is physically able to play, how much will be able to do? He'll be wearing a flak jacket, an extra burden that could affect his ability to throw the ball. The Steelers also have to deal with the reality that another big hit could end Roethlisberger's season. That's a genuine concern with the Steelers' offensive line.
As bad as Cleveland was, the Steelers are still in good position to make the playoffs. They'll still have a chance even if they lose this week.
The first step toward improvement is forgetting everything that happened in Cleveland.
Pick and choose
The Pirates have until Friday to decide which arbitration-eligible players will receive contract offers. If they don't get an offer, they can become free agents.
Two of the players on the bubble are pitchers Jeff Karstens and Charlie Morton. Karstens was limited to 90 innings last season by shoulder and hip injuries. Morton's season ended early because of ligament replacement surgery that will keep him out for the start of the 2013 season.
The Pirates should bring both of them back. Pitching always requires reinforcements. Karstens and Morton have both shown they can be effective.
They need to bring them back for the sake of depth. It's a risk, but one worth taking.
Mehno can be reached at email@example.com


text:
Top Definition
the penis, cock, hog, wang, etc
i paid this chick 37 cents to play my cum trumpet.
por tony 28 de Janeiro de 2004
Trending Now
Can you define these popular missing words?
A sexual act where during oral intercourse the male withdrawals from the woman's (or man's) mouth after ejaculating. The woman then keeps the seamen in her mouth, in the cheek pockets. The man then slaps both cheeks at once and the woman makes a gurgle/trumpet noise as she expels the seamen.
After becoming bored with the angry pirate Koko decided to give her a cumtrumpet. What he did not plan for was the trumpet to be shot at him.
por cumtrumpet 20 de Setembro de 2010
When someone who has recently swallowed semen plays the trumpet; they are then referred to as a Cumtrumpet.
After taking a Risk, Kerry then proceeded to play the trumpet- prompting Stephen to call her a 'cumtrumpet'.
por Amalric 05 de Maio de 2010


text:
Poison – that's how nutritionists view certain ingredients in packaged foods, substances so toxic to the human body you should put the package back and flee the premises.
High fructose corn syrup, trans fat, artificial dyes and coloring, monosodium glutamate. The first is found in everything from pretzels to sports drinks to cereals. But no matter how common high fructose corn syrup has become, nutritionists contend it's a dietary evil capable of spiking your blood sugar, making you gain weight and turning something relatively healthful such as juice into a junk food.
Now that the highly publicized scandal over trans fat or partially hydrogenated fat, has died down, the ingredient has started sneaking back into foods like power bars and microwave popcorn. It's a double whammy for cholesterol – raising the bad (LDL) type and lowering the good (HDL).
You wouldn't know it, but many packaged foods have colors and dyes added to them to make them look more like the real deal. Nutritionists caution against any product that contains them, saying they're nothing but chemicals and harmful ones, to boot.
Some additives like MSG and BHT don't even fall into the category of food, and food experts say to avoid them like the plague.
"BHT is a human carcinogen," said Jennifer Letellier, a local naturopath. "They put it in petroleum products."
So while you're searching the labels for sugar, salt and fat, add these five nutritional disasters to your list.


text:
Top Definition
an orgasm, usually intense.
"He got me to the big O last night.
από Starla Pureheart 29 Ιούνιος 2002
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Can you define these popular missing words?
Paradigm City is a place without a past. 40 years ago, something happened that wiped away the memories of everyone in it. Unfortunately, the people of Paradigm City were very busy before then, making Megadueses (giant robots) and monsters. People who were born after the memory wipe are gaining/recovering memories of the past and using them to build newer threats. Roger Smith keeps Paradigm City safe with the help of The Big O (a faithful giant robot), his butler Norman, and the android Dorothy. As problems mount and more memories surface, Roger's past and Paradigm's future begin to become suspect.
Big O aired in the U.S. on Toonami in 2001. There are a total of 26 episodes.
από ♫ Highway to Hell ♫ 10 Σεπτέμβριος 2010
super intense orgasm in which female ejaculate is released (not urine)... speculation puts phenomena at 1 out of 20 women able to achieve
Cheryl knew all about the Big O
από TXDOC 28 Μάρτιος 2006
a giant robot in the anime big O
guy:*looks at watch* BIG O! *robot appears*
από O_oo_O 17 Ιούλιος 2003
1. an orgasm, a sexual climax
2. opium
Once I reach the big O, there is no turning back.
από The Return Of Light Joker 4 Νοέμβριος 2007
A sexy, Mexican male typically found in western areas of the continental U.S. Bigos are approximately 6 feet tall and vary in weight. Bigos are dark in color, including skin, hair and eyes and the voice of a Bigo resonates directly from your ears to your panties, creating instant moisture in the vaginal area. Bigos are strong and rude, yet possess a softness that is not often exposed. A genuine Bigo drinks beer, considers football a religion, loves large breasts, and has amazing preferences in music.
"That dude must be a Bigo...did you see him grill that meat, drink his beer, and get that girl off all at the same time?!
από r.v.r 15 Ιούλιος 2014
Traditional polish dish that consists of sauerkaut, sausage & mushrooms. Mainly eaten with bread
Englishmen hate bigos, but for poles it's delicious
από Ozon 5 Ιανουάριος 2006


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on February 14, 2013 - 6:04 PM
NIAGARA FALLS – A city man, recently charged with marijuana possession, was arrested a second time in less than a month after narcotics investigators said they found him Wednesday with 27 individually bagged packages of marijuana and a loaded handgun.
Anthony Bogan Sr., 54, was charged with fifth-degree criminal possession of marijuana, and third- and fourth-degree criminal possession of a weapon at 2:22 p.m. at his home in the 1500 block of LaSalle Avenue, police said.
"This is the second time we've [arrested] this guy in a month and he went right back to work where he left off," said Narcotics Detective Lt. Theodore Weed. "He just kept on dealing."
Weed said this has been a continuing investigation based on complaints from block club members over a number of months.


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The clock was under a minute, and Heidelberg was down 14 to Wittenberg in the Division III playoffs at Frost Kalnow Stadium.
A loss to the Tigers was all but assured, and the home side of the stands - which were packed and filled with loud fans - was quiet.
As I made my trek back up to the press box from the sidelines, there was plenty of disappointment, an understanding that this season, this 9-2, playoff-qualifying season, was about to end.
Then I heard this:
"It's not over. If we get a touchdown and recover an onside kick, we can tie this game!"
Wittenberg ended Heidelberg's season, but couldn't end its hope.
And that's what people will remember about 2012. When the days pass, when the frustration subsides, when the big picture becomes clear:
The program has turned it all around.
It's not just about the history. None of the players on Saturday's roster were part of the 2006 team that went 0-10. Only four assistant coaches remain from that year.
People who follow this program now expect it to win every week. That's a far cry from even two years ago, when HU was 5-5, still in the middle of the Ohio Athletic Conference standings.
Heidelberg has won every game but two held in Tiffin over the last two seasons. It has done
it with a strong defense, a tough running game and big plays from the passing game.
I'm not trying to put a positive spin on Saturday's loss. I'm sure the players feel like they should have won. Any game where a team leads 28-6 and 31-13 should make a team comfortable of victory. When it didn't happen, fans and even players seemed more stunned than anything.
It was tough seeing the players, who had so much to celebrate at times during the game, have to accept a stunning season-ending defeat.
Heidelberg has become a team that expects to win, and it has a fan base that expects to win.
And it showed with a huge crowd, most dressed in orange.
"It was phenomenal just to see the amount faculty as well as student and community support that we had," said linebacker Craig Sykes, a senior. "We've definitely seen our impact on this community and what we've done. How they know us now, how they recognize us now compared to four years ago."
Six years ago, the Student Princes played in front of family and a few others at Frost-Kalnow Stadium. When they moved their home games on campus for the second half of the 2009 season, the attitude had changed, and the crowds were bigger.
But it was nothing like Saturday.
"Last year and certainly this year, it's been resounding," Heidelberg coach Mike Hallett said, "how unbelievably great the Tiffin, but also the Seneca County, community has been, and really rallied around us. Today was unbelievable."
Looking at the roster, its easy to think that Heidelberg will be back near the top of the league for years to come. Star running back Cartel Brooks is a sophomore. Bryan Lacey, his backup who has run for more than 350 yards in the last two weeks, is a freshman. Quarterback Michael Mees is a sophomore. Derek Hug, who caught three touchdown passes Saturday, is a sophomore. Ben Poirier, a star defensive lineman, is also a sophomore, while Chadd Williamson (who injured himself Saturday in the second half) is a junior.
But success is never a guarantee, no matter how much potential there is for it. Gary McKillip, a member of the 1972 Stagg Bowl championship team, said earlier this week that Heidelberg's players expected to be as good in 1973, but injuries caused them to go 6-3.
But senior Justin Suddeth, a defensive back, managed to be both reflective and optimistic just minutes after his career ended.
"We came in with a goal, and the goal was to help turn this program around," Suddeth said. "Four years we went 4-6, 5-5, 8-3, now 9-2 ... We can't wait to see what's ahead."
The loss Saturday will sting for the players, coaches and fans for a while. But perhaps it's just a setback for a program that will continue to rise.
Zach Baker is the sports editor for The Advertiser-Tribune.
Contact him at:


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To support the outreach objectives of the Division of Student Affairs, enhancing facilities and programs for both students and staff, by providing comprehensive services and expertise in the procurement of external funding.
Seek out new funding opportunities at the federal, state, and private levels Actively participate in the conception, design, and development of projects Contribute to the research, writing, and editing stages of the proposal formulation process.
The University of Texas at Brownsville website uses Javascript.
To access this page as it is meant to function please use a Javascript
enabled browser.


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on May 24, 2013 - 10:00 PM
NIAGARA FALLS – Fourteen people, including alleged drug dealer Ray A. Harris, were arrested as Niagara Falls Police Narcotics Bureau detectives raided what was described as "a classic crack house" Thursday night on 19th Street.
Harris, 27, who lives on Niagara Avenue, was arrested on felony criminal possession of controlled substance charges, Capt. David LeGault, chief of the Narcotics Bureau, said detectives found quantities of crack cocaine, powder cocaine, marijuana, prescription pills and heroin in plain view on a dining room table as the raid began about 9:25 p.m. in an apartment at 459 19th St. As detectives entered Harris unsuccessfully tried to flush various illegal drugs down a toilet.
The raid followed a lengthy police investigation and complaints from neighborhood residents and community groups.
The thirteen other men and women in the apartment during the raid were all charged with misdemeanor drug counts or loitering for the use of drug charges,


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Systemwide Events Calendar
Tai Chi (Yang Style)February 4, 6:30pm - 8:30pm
Windward Campus, Hale Kuhina 115
Learn this venerable Chinese martial arts to improve your mental and physical health. It is an excellent prescription for stress relief and is noted for increasing the mind's ability to focus. While strengthening and limbering the body, it also increases circulation and has been shown to lower blood pressure. It is a subtle and sophisticated martial art. New students are welcome at the first class in January, April, July and October.
Instructor: Staff
Course Fee: $25 + $15 lab fee (payable to instructor)
Course Code: P02HE102
Dates: Mondays & Wednesdays, February 4 - 27 (no class: 2/18)
Times: 6:30 p.m. - 7:30 p.m. (Beginners); 7:30 p.m. - 8:30 p.m. (Advanced)
Meetings: 7
Event Sponsor
Career and Community Education, Windward Campus
More Information
Career and Community Education, 235-7433, email@example.com
|Monday, February 4
|The Wellness Center - Fitness Class Schedule
Maui Campus, Pilina Bldg., Wellness Center
|How to Study Accounting
Leeward Campus, LC 102
|Honors Program Upper Division Information Session
Manoa Campus, Honors Lounge in Sinclair Library
|English Final Oral
Manoa Campus, Henke 325
|Summer Study Abroad in Berlin, Germany
Manoa Campus, Moore Hall 319
|Honors Program Selected Studies Information Session
Manoa Campus, Honors Lounge in Sinclair Library
|Warrior Tie-Dye with UH Mens Basketball
Manoa Campus, Hemenway Hall Courtyard, Manoa Gardens
|Wow! That's Engineering!
Waipahu High School Cafeteria, 94-1211 Farrington Highway, Waipahu, HI 96797
|Tai Chi (Yang Style)
Windward Campus, Hale Kuhina 115
- Highlighted dates have scheduled events.
- Select the date to view all events for that day.


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67 results
ARCONA is known and respected for its high quality, luxury formulations and their unparalleled ability to make a positive change to the skin. The key to ARCONA's effectiveness is its active ingredients and the way they are combined and processed. Cosmeceutical-grade ingredients, such as enzymes, antioxidants and amino acids, are formulated to work synergistically to deliver powerful results. These active ingredients are cold-processed at very low temperatures, in small batches, to keep them active and effective. Because cold processing is labor and time intensive, most skin care products, even the expensive ones that may begin with quality ingredients, are heat processed, which ultimately leaves nutrients lifeless and ineffective.
The ARCONA brand is committed to using the best of what science has to offer to enhance the benefits of the best nutrients that nature has to offer. The brand relies on natural extracts as the key ingredients in their formulas, making them ideal for those committed to leading greener lives that include less exposure to synthetics. Instead of spending time creating new cosmeceutical chemicals, the scientists at ARCONA develop ways of making natural ingredients more ideal for the skin. Their technologies have led to the chirally correct molecule, an ingredient that is optimized to make it more readily usable by the skin cells for improved effectiveness.
The approach to creating a skincare regimen using ARCONA products is known as The Daily Five. ARCONA has developed their collection to make everyday skincare as simple as can be. In the morning, three basic types of products are intended for use: a cleanser or exfoliating scrub, a moisturizer and a product that offers protection against sun damage and free radicals. The evening regimen includes cleansing and toning followed by regenerating the skin tissue with the powerful natural formulas in the ARCONA collection. Many women and men can develop an entire ARCONA skincare routine with just five products, keeping costs and the number of steps in a regimen to a minimum.
With ARCONA, you can achieve your skin care goals without having to expose your skin to petrochemicals, parabens or artificial colors and fragrances. Shop the collection now!
In the late 80s in Los Angeles, ARCONA skin care products were developed with the goal of providing holistic skin care to women all over the world. ARCONA products were originally intended for the Hollywood elite but every day women can now enjoy the benefits of ARCONA skin care products.
In an era where so many women are opting for cosmetic procedures to improve the look of their skin, ARCONA products offer an alternative in the form of effective ingredients that work with the body naturally to improve the quality of the skin. ARCONA skin care products are developed in a process that preserves the integrity of every high quality ingredient, ensuring maximum potency and consistency with every application.
ARCONA products are as luxurious as they are effective, incorporating beautiful natural fragrance and color with delectable but practical packaging. ARCONA is dedicated to providing exceptional skin care for achieving and maintaining radiant skin.
For every skin type, there are ARCONA skin care products that work with the skin to leave it balanced and healthy. ARCONA products avoid harmful chemicals and additives which can create problems for the skin and diminish the efficacy of the actives. All ingredients are non-comedogenic and will not cause acne breakouts.
ARCONA skin care products incorporate plant extracts, essential oils as well as vitamins and minerals that penetrate the layers of the skin to holistically correct and prevent damage, restoring life and luster to the complexion. ARCONA products are intended to be used every day, providing a long-term cumulative improvement.


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Closed Captioned
Go behind the scenes on two Las Vegas photo shoots with professional photographer Mike Hill, and learn how to create captivating photo essays from start to finish. Navigate on-location demands, and collaborate with subjects for candid, authentic photos. Effectively frame compelling shots using compositional principles, and learn when and how to adjust available light with on and off-camera flash and affordable modifiers. Then, enjoy step-by-step guidance through Adobe Lightroom to quickly narrow down hundreds of photos to a small collection of shots that reveal your subject's story.
Mike offers recommendations on pre-shoot planning and shares photos from his portfolio as he explains how to tell a person's story through striking imagery.
Learn professional tips on how to organize and pack for a day in the field and discover the best practices for assessing the environment you're going to shoot in.
Mike demonstrates shooting a portrait session with clients on location. Learn to efficiently set up your gear, light your subjects and direct with ease while getting the shots you want.
Learn to tackle tricky issues like framing and working outdoors while gaining more experience with composition, lighting techniques and storytelling through details.
Explore various methods to improve your efficiency and organize hundreds of photos easily with Mike's step-by-step tutorial on using Adobe Photoshop Lightroom 5.
Learn professional editing tips with Mike's assistance as you gain an overview of the various tools Lightroom 5 offers for photo editing.
"I have taken a lot of online classes. As an educator, I have trained to become an online teacher. Craftsy has the best instructors, layout, lesson plans and videos of what is currently available on the internet now � Way to go Craftsy!"
- guidance4u


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Learn how to mill your own flour at home on the cheap using nothing but a coffee grinder.
Ready to go beyond white bread? Learn about the baking properties of whole wheat flour and how to successfully use it in your doughs.
Ready to bake your first loaf of bread? In this lesson you will learn to bake the right way starting with a white sandwich bread.
Learn about the tools you will need to start baking at home.
Tired of making calculations to convert between instant yeast and fresh? Have a recipe that calls for osmotolerant yeast but you only have active dry? Try this simple to use online tool that will convert between various yeast types!
At a breaducation, our goal is to teach people the knowledge and skills to bake the bread of their dreams. We want you to create bread on your terms using the ingredients you want and in a time frame that fits your busy schedule. We want to free you from supermarket mediocrity and recipe following. At a breaducation you will learn to create your own recipes and have them be good! Really, really good.
Bread baking is fun, challenging and highly rewarding. Take time to learn the craft and you will be producing bread that surpasses what is found in most supermarkets and will rival the best bakeries(not an exaggeration). On top of that, you will have complete control over every ingredient that goes into the bread you make. No more dough conditioners, preservatives and fake bread for you!
Ready to start baking? We encourage you to head over to our lessons page and dive in! There you will find everything you need to know to get off the ground producing some beautiful and delicious loaves of bread.


text: The 3851 hectares of vineyards in Vaud are distributed among four different regions, each of which has its special topography and climate. The Vaudoise wines produced here – mainly Chasselas (almost 70%), Gamay (11%) and Pinot Noir (11%) – are defined by their individual region of origin. This explains the creation of the Canton's 28 special labels (Appellations d'Origine Contrôlées).


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Systemwide Events Calendar
Red Hat System Administration ISeptember 26, 2013 - December 3, 2013
Honolulu Campus, 874 Dillingham Blvd
Besides traveling to the mainland, this is the only place in Hawaii where you can take official in-person Red Hat training.
This course is designed for IT professionals who are new to Linux® and require core Red Hat Enterprise Linux skills. This course focuses on essential administration tasks that will be encountered in the workplace, including installing the operating system, establishing network connectivity, managing physical storage, and performing basic security administration.
Event Sponsor
PCATT, Honolulu Campus
More Information
PCATT Registration, 845-9296, firstname.lastname@example.com, http://pcatt.org
|Sunday, October 6
|Opening reception for Convergence: Glitch_Click_Thunk, Featuring Mark Amerika
Manoa Campus, Art Building, University of Hawai'i Art Gallery
|Trip Around the Island exhibit
Manoa Campus, Hamilton Library Bridge Gallery
|Intramural Sports - Basketball
Maui Campus, Baldwin High School Gymnasium
- Highlighted dates have scheduled events.
- Select the date to view all events for that day.
Ongoing Events
- The Wonder of Learning: the Hundred Languages of Children Exhibit
- Waikiki Parc Features Nicole Naone
- Course Reserves Deadlines and Information
- SAPFB Spring 2014 Funding Cycle
- Red Hat System Administration I
- EWC Arts Exhibition: Bollywood & Beyond: Costume in Indian Film
- Kalaupapa -- A Source of Light, Constant and Never-Fading
- Spring / Fall
- Convergence: Glitch_Click_Thunk, Featuring Mark Amerika
- Trip Around the Island
- Big Love


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When your children ask to see dolphins or whales anywhere that they are kept captive, such as SeaWorld or "swim with the dolphins" parks, think twice. There is a very dark side to these places.
Dolphins and whales are intelligent, social mammals that live in family groups and swim long distances in the wild. In theme parks, they suffer from sensory deprivation, social isolation and nutritional deficiencies, and they die from captivity-induced diseases. They perform for food rewards and appear to be smiling because their faces are shaped that way (watch "Blackfish").
The methods by which they are acquired are also questionable. Worldwide, the largest source of dolphins for the entertainment industry is the infamous Japanese town of Taiji (location of the movie "The Cove"), where dolphins and small whales are treated with unspeakable brutality. Although the importation of wild dolphins is now illegal in the U.S., SeaWorld has taken no action against animal trafficking, and it continues to provide the entertainment and business models for this unscrupulous industry. These parks are based on cruel and unethical practices and should not be supported.
Children have open minds. Tell them it is cruel to keep dolphins and whales captive, that they need to swim in the ocean and, just like people, be with their families. Offer alternatives like watching one of many educational films showing dolphins and whales in natural habitats or take them on a dolphin-whale watching trip—children love it! You are teaching them to respect the wild animals and protect them, which is good for them, good for the dolphins and whales and good for the planet.
—Jean Karlsson, Amboy
Location, ST | website.com


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Strongid C
Strongid® C is a daily horse wormer that provides a continuous, preventive level of pyrantel. This feed-through dewormer is effective against a variety of intestinal worms. 25 lb (100-day supply). Read more...
Strongid® C is a daily equine dewormer designed to be administered every day to provide a continuous, preventive level of pyrantel in the intestinal tract. This feed-through horse dewormer may help prevent migration of large strongyle larvae. It also controls a variety of small strongyles, pinworms and ascarids. Contains 1.06% pyrantel tartrate. May be used on pregnant mares and foals. 25 lb (100-day supply).
Overall Rating: 4 StarsAverage Based on 1 Reviews Write a Review
Strongid has proved very effective in my experience. It is well made flavor wise, as horses will eat it readily mixed into their feed.
100% Satisfaction Guaranteed - Your Money Back Any Time, for Any Reason.
Smith Brothers is proud to offer a 100% satisfaction guarantee on all of our products. We stand behind the quality of our products, and should you not be satisfied with your purchase, simply return it and we will refund, replace or exchange it for you.


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LC-MS Gains Favor Due To the...
Expanding Use of NGS Has Largely...
Wall Street Decline Takes Its Toll...
As Immunotherapy Revolutionizes the Cancer Treatment...
A whole-exome sequencing project has generated what researchers claim is the most comprehensive map of genetic alterations in melanoma assembled to date. The project, carried out by a National Human Genome Research Institute (NHGRI)-led team, found that the majority of melanoma tumors analyzed had alterations in glutamate signaling pathway genes, suggesting that this pathway could represent an important target for the development of therapeutics.
Most significantly, the study found that some 33% of melanoma samples had mutations in a newly identified glutamate receptor subunit gene, GRIN2A. In addition, 4% of tumor samples analyzed sported an identical mutation in the TRRAP gene. The results are published in Nature Genetics in a paper titled "Exome sequencing identifies GRIN2A as frequently mutated in melanoma."
Approximately 69,000 individuals were diagnosed with invasive melanoma in the U.S. in 2010, and there were about 8,700 deaths from the disease the same year, report senior author Yardena Samuels, Ph.D., at the Cancer Genetics Branch of the NHGRI's intramural research division, and colleagues. Moreover, while whole-genome analysis of a single melanoma has been completed and other studies have linked the disease with mutations in genes such as BRAF, cKit, and ERBB4, no comprehensive analysis of this tumor type has yet been performed.
To further mine the genetic basis of melanoma and home in on true disease-related genes, the researchers carried out whole-exome sequencing of 14 metastatic melamona tumor DNAs from untreated individuals and matched normal controls. The resequencing project was carried out at the NIH Intramural Sequencing Center.
The analysis involved a number of steps to eliminate germline mutations and try to ensure only potentially tumor-specific somatic mutations were included in their final count. One step involved eliminating inherited alterations already annotated in dbSNP and the 1,000 Genomes Project.
A number of techniques were then applied to identify true mutations from all the sequence alterations identified. The researchers claim these refinements removed about 18% of the genetic alterations and provided a 97.9% coverage rate, a 2.4% false-negative rate, and a sensitivity of 81%. In further analytical steps the researchers pinpointed which of the somatic mutations were likely to be true 'driver' mutations that played a role in melanoma neoplasia and which were functionally inert 'passenger' mutations.
Of 86 genetic changes that appeared to be somatically mutated at higher frequencies in melanomas, 16 genes, including BRAF, were characterized as melanoma drivers. Significantly, a gene known as GRIN2A, which is located on chromosome 16p13.2, was found to be mutated in 33% of the original tumor sample set and in 25% of a larger set of melanoma samples. GRIN2A encodes a glutamate (N-methyl-(D)-aspartic acid (NMDA)) receptor subunit, and there is some indication that this gene acts as a tumor suppressor, Dr. Samuels notes.
"The mechanism by which mutations in GRIN2A have a tumorigenic effect is unclear; however, their frequency strongly suggests that they play a major role in melanoma and are worthy of future investigation," the authors write.
In addition to BRAF, the researchers identified nine more genes that harbored a recurrent, or hot-spot mutation. Screening hot-spot mutations that occurred in different tumors within the initial sample set against an additional 153 melanomas found that an identical mutation in the gene for transformation/transcription domain-associated protein (TRRAP) was present in six separate melanomas. "This was one of the most important discoveries in the study, since we never expected to identify novel not-spot mutations," Dr. Samuels admits.
"The likelihood for the occurrence of six identical mutations is approximately 5 × 10−20, suggesting that the TRRAP hotspot mutation is important," the authors write. They suggest the nature, pattern, and functional evaluation of the TRRAP recurrent mutation suggest that the gene does function as a true oncogene. "The positions of the mutations in TRRAP imply that they are likely to be oncogenic, as we observed no truncating mutations, and 100% of the alterations occurred in one location. Subsequent sequence analysis of all coding exons of TRRAP in 25 additional melanomas revealed no additional nonsynonymous alterations."
Interestingly, knocking out TRRAP in cell lines had minimal effect on the survival of cells expressing the wild-type gene but substantially increased the apoptosis rates of melanoma lines carrying mutant TRRAP gene. This confirms the putative role of mutant TRRAP cancer cell survival. "Thus, mutant TRRAP is essential for melanoma cell survival, which is consistent with previous results showing that TRRAP knockout mice are embryonic lethal," the researchers note.
The approach to genetic analysis used for the study also provided the researchers with an opportunity to look for new gene pathways involved in melanoma These results highlighted the glutamate signaling pathway as highly significant. Interestingly, in addition to GRIN2A, another highly mutated gene identified by the genetic analysis was PLCB4, which encodes a downstream protein involved in metabotropic glutamate receptor-related signal transduction.
"Some of our findings have potential therapeutic implications, as glutamate pathway modification has previously been shown to limit tumor growth," the authors conclude. "Further investigation of this pathway in melanoma as well as development of such inhibitors is warranted."
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Central Bank lowers interest ratesLunes, enero 28th, 2013
With an interest rate reduction from 4,25 to 4,0 percent, Colombia's Central Bank will both boost the economy, which experts say isn't growing to its full potential, and encourage Colombians to accumulate more debt.
"Each person and bank must take on the task of assessing if they are able to take on more debt and how to use available credit options", said bank chief, Jose Dario Uribe.
Uribe also said that the decision was made considering that, on average, the economies of Colombia's commercial partners have grown as much as expected. The Board of Directors also decided to extend daily dollar purchases thru May and expects to accumulate 3,000 million dollars, with daily purchases of no less then 30 million dollars.


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Voluntary sector comes to Turkey to move agenda forward
17 April 2011
Civil society and voluntary organizations are key players pushing for progress, and tapping this vast resource could be a major step towards reaching the Millennium Development Goals. Volunteering organizations and government delegates are therefore gathering in Ankara as part of a series of get-togethers aimed at paving the way for a World Volunteer Coalition.
This year marks the tenth anniversary of the International Year of Volunteers, and a number of national and global organizations are working together on common objectives. The Ankara meeting aims to start shifting the development debate in the region, and will be followed in May by consultations for Asia and Africa in the Philippines and Senegal. The first such meeting took place in Quito, Ecuador, during April.
Delegates at each regional conference are invited to formulate recommendations on volunteering for peace and development. Bringing together the diverse range of organizations will also give them the chance to share a multitude of ideas and experiences, while strengthening partnerships and synergies.
The meeting in Ankara from 18-19 April brings together representatives from across the non-profit sector, from national civil society organizations to government ministries. Several Turkish volunteering organizations, such as Türkiye Eğitim Gönüllüleri Vakfı and Gençlik Servisleri Merkezi, are also attending. The Chief of the United Nations Volunteers (UNV) programme Development Division, Mr. Ghulam Isaczai, will be available for media interviews at selected times.
Turkey was chosen as the conference venue due to its unique position as a bridge between continents. As well as the host nation, Albania, Bosnia and Herzegovina, Egypt, Jordan, Kyrgyzstan, Lebanon, Morocco, Sudan, Syria, Tajikistan, Tunisia, Ukraine, Uzbekistan and Yemen are all represented along with a presence from the European Volunteer Centre under the auspices of the European Year of Volunteering.
A United Nations General Assembly session during December 2011 will also be dedicated to volunteering.
Philip Sen
Communications Officer
International Year of Volunteers +10, UNV
Tel: +49 228 815 2019 / +49 174 757 3209
philip.sen [at] unvolunteers.org
About the tenth anniversary of the International Year of Volunteers
Volunteering empowers people to take an active part in the development of their own communities, to take responsibility for the needs of others, and to make an impact in their own lives. Volunteering often starts at home: but together, volunteers can change the world.
It is 10 years since the International Year of Volunteers in 2001, and through United Nations General Assembly Resolution 63/153 (2008), the United Nations called for this anniversary to be marked across the planet. The United Nations Volunteers (UNV) programme was designated as the focal point for IYV+10 in order to catalyse action at the national, regional and global levels. The aims of the wide range of partners are to promote the values of volunteering, recognize the value of volunteering, build and reinforce volunteering networks both nationally and globally, and help people tap their potential to make a difference to peace-building and development.
See www.worldvolunteerweb.org for more.


text:
2009-9-5 Order Reselecting Carrier
This Other document was issued by the Department of Transportation (DOT)
For related information, Open Docket Folder
By this order, the Department is re-selecting Great Lakes Aviation, Ltd., (Great Lakes) to provide essential air service (EAS) at Dodge City, Garden City, Great Bend, Hays, and Liberal for the two-year period from October 1, 2009, through September 30, 2011, at combined annual subsidy rates of $8,897,565.
No documents available.
Tracking Number:
Document Information
Show More Details
Date Posted: Sep 11, 2009
Submitter Information
Submitter Name: Susan Kurland
Mailing Address: Assistant Secretary for Aviation and International Affairs
Country: United States
Comments Received*
Docket Information
This document is contained in
Related Dockets:
Related RINs: None
* This count refers to the total comment/submissions received on this document, as of 11:59 PM yesterday. Note: Agencies review all submissions, however some agencies may choose to redact, or withhold, certain submissions (or portions thereof) such as those containing private or proprietary information, inappropriate language, or duplicate/near duplicate examples of a mass-mail campaign. This can result in discrepancies between this count and those displayed when conducting searches on the Public Submission document type. For specific information about an agency's public submission policy, refer to its website or the Federal Register document.


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A local high school student has selected a senior project to help a local officer. K9 Officer Macy of the Elkins Police Department will receive a bullet-proof vest because of the efforts of Brandon Simmons, an Elkins High School senior.
"I chose this project as part of my experience at the West Virginia State Police Junior Troopers Program," Simmons said. "They had a dog named Officer Zoe that was killed in the line of duty in March 2011. She was killed when they were trying to apprehend a victim with a gun, and Zoe jumped in front of her human partner, taking the bullet."
Simmons' mother, Angie Pritt, said her son had always wanted to be in law enforcement.
Article Photos
Elkins High School senior Brandon Simmons is helping local K9 Officer, Macy, by raising funds to purchase a bullet-proof vest for her. Simmons is using the experience as his senior project requirement for graduation. (Submitted photo)
"Brandon always entertained the thoughts of being a police officer," Pritt said. "He changed his mind when Cpl. Andrew Loudin was shot. Brandon also chose this project because he has always loved animals. He would have a zoo if we would let him.
Simmons said he contacted K9 Officer Macy's partner and handler Sgt. C.D. Cross of the Elkins City Police. He said Cross selected the vest for Officer Macy.
"The vest will cost $849.99," Simmons said. "The place we are ordering it from gave me a discount of $150 when they learned about my project to provide the vest."
Sgt. C.D. Cross said he was pleased with Simmons' project to provide protection for Officer Macy.
"This is just fantastic," Cross said. "I am so pleased Brandon took on this project and so happy the community is helping make this possible."
Cross said Officer Macy will be 3-years-old in April and that she is doing a great job.
"On Friday evening, we had three officers out and Officer Macy helped us detect five vehicles with drugs," Cross said. "Four were misdemeanors and one felony. She is really is really doing a fantastic job."
Simmons said he already has $199 in donations.
"We are running a Facebook page called Brandon Simmons senior project," Simmons said. "Donations can be made there or at Citizens Bank of West Virginia. Donations can also be made at firstname.lastname@example.com"
Simmons said through his project, he has learned that vest are important and can save lives.
"These dogs are not just animals," Simmons said. "They are an officer and a partner."
Simmons said he hopes to hold a bake sale, a dog basket raffle and an event where Cross will bring Officer Macy to meet members of the community.
Pritt said she is proud of her son's work.
"I think it shows maturity on his part to be so aware that animals need protection as well as humans," Pritt said. "To me, people think animals are expendible but they are not."
Simmons said once he raises the money for the vest, he will purchase the vest and present it to Officers Cross and Macy. Additional information about this project is available by calling 304-636-8517.


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Published October 31, 2013
It's not easy to pick out a military veteran among the thousands of students walking around UB's three campuses.
With the troop drawdowns in Iraq and Afghanistan, veterans have been entering high education, including UB, at increasing rates. UB estimates that several hundred students currently on campus have either recently served or continue to serve in the armed forces while studying at the university. About 400 are receiving veterans' benefits.
But these are not your traditional 18-to-22-year-old college students. As Dan Ryan, who heads UB's new Veteran Services Office, puts it: "They're not interested in the world's largest banana split."
The Office of Student Affairs opened the Veteran Services Office this semester to celebrate the accomplishments of student veterans and provide access to the services they need to help them succeed at UB. The office is located in 101 Allen Hall, South Campus. A grand opening and open house will take place at 1 p.m. on Nov. 7.
The office serves as a central point of contact and referral for veterans looking for information and services, says Ryan, who will continue to serve as director of off-campus student services.
"The mission of the department will be to ease the transition of veterans and help them balance college life with their military, career, family and personal goals," he explains. "UB's Veteran Services Office will be a comfortable place where student veterans can get support on veterans' benefits, academic policies and on- and off-campus resources to meet their unique needs."
In his new role, Ryan also leads a Veteran Services Committee that includes representatives from UB's offices of Veteran Affairs, which handles veterans' benefits; Academic Advising; Financial Aid; Admissions; Campus Living; Orientation, Transition & Parent Programs; Wellness Education Services; Counseling Services; Accessibility Resources; Career Services; Special Events; and Student Life, as well as interested representatives from other decanal units.
He also is convening an advisory panel for students that will assist in the assessment and planning of services for student veterans.
The Veteran Services Committee has been busy planning UB's annual Veterans Day celebration, to begin at 11 a.m. Nov. 11 with a flag-raising ceremony at the Coventry Circle flagpole in front of Alumni Arena on the North Campus. The ceremony will feature the University Police color guard and a performance of the national anthem by UB's Thunder of the East marching band.
Following the flag-raising, participants will move into the Center for the Arts atrium for a program. Speaking will be Barbara Ricotta, associate vice president for student affairs; Donald Herzog, director of sponsored projects services, representing the U.S. Army; student Dale Gump, representing the U.S. Navy; and Col. Robert G. Kilgore, vice commander of the 107th Airlift Wing, New York Air National Guard, representing the U.S Air Force.
A veterans' photo exhibit also will be on display in the CFA atrium during the program. The photos later will be displayed throughout the year at various sites on campus.
For more information about the Veteran Services Office, contact Ryan at 829-3536 or firstname.lastname@example.com.


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on March 29, 2013 - 1:07 AM
SUNRISE, Fla. — T.J. Brennan was preparing for a routine off-night dinner March 15 in Buffalo when his cell phone went off. Darcy Regier was at the other end of the line with the stunning news that Brennan's Sabres career was over and he was off to play for the Florida Panthers.
"It hit me by surprise. It's a little surreal at first," Brennan said Thursday as he prepared to face his old team in BB&T Center. The Panthers bested the Sabres, 5-4 in a shootout.
"I was going out to dinner and the next thing you know I got a call. I had to call my family and then I started getting calls from guys down here. I was a little surprised but there's a great opportunity here and I'm trying to make the best of it."
Brennan, a former second-round pick by the Sabres, was essentially dumped for a fifth-round pick. He had struggled in several attempts to become a regular in the NHL but the move was still a mild surprise given the likelihood the Sabres will deal veteran defensemen but so quickly gave up on a 23-year-old blue liner. The Panthers almost certainly jumped at Brennan in part because his coach at Portland of the AHL was current Florida coach Kevin Dineen.
Brennan had one point (a goal March 5 at Carolina) in 10 games with the Sabres this year and was a healthy scratch 17 times after having a big year in Rochester, where he was leading the Amerks in goals and points until the lockout ended.
Does Brennan feel the Sabres gave up on him too early?
"I'm not sure. That's not really my call," he said. "Obviously I tried to make the best of the opportunity I had in Buffalo. I guess I wasn't in their plans. When I came here to Florida, I've been with Kevin before and am looking for more opportunity. It's good to be reconnected to him and I wish all the best to Buffalo. Not fitting in their plans, that's just the way it goes sometime.
"Coming in here it was a little more comforting having a coach who knew how I played already. I didn't have to prove myself to the full extent. I just want to prove myself at the NHL level."
Brennan played a career-high 23 minutes, 42 seconds and scored a goal March 16 in his Florida debut against the New York Islanders. He had an assist in his third game and played 19:24 but was minus-2 in his fifth game Sunday in the Nassau Coliseum. The Panthers made him a healthy scratch Tuesday in Toronto but returned him to the lineup Thursday.
"TJ's been fine," Dineen said. "He's got a heavy shot and we're having discussions on the way we play in certain situations but TJ has been everything we expected that he would be.
"The growth curve is always a long one for defenseman in most cases. Whether it's TJ or [Panthers teammate] Erik Gudbranson or Tyler Myers. Things happen on the defensive side, they seem to stick out a little more. But I have no doubt he'll continue to work on his development stage."
One thing that Brennan didn't have to worry about was some Florida family members canceling plans to see the Sabres play here Thursday. He said they had bought tickets weeks ago but were still able to see him play, except now on the other side.
"It's weird I'm playing against Buffalo," he said. "Seeing some of them on the other side of the ice is definitely a little different."
Sabres winger Thomas Vanek did not take the morning skate and missed the game with the upper-body muscle strain he suffered Tuesday at Tampa Bay. His status for the back-to-back home games this weekend against Washington and Boston is uncertain.
Andrej Sekera returned to the lineup after missing five games with an upper-body injury and rookie Mark Pysyk was scratched on defense. To accommodate Drew Stafford and John Scott in the lineup, the Sabres also scratched rookie Brian Flynn. He has no goals in his last four games.
• Sabres winger Steve Ott played his 600th career game Thursday. Defenseman Christian Ehrhoff will play No. 600 Saturday at First Niagara Center against Washington.
• Panthers rookie Jonathan Huberdeau entered the game leading NHL rookies in goals (12) and was second in points (21). With 12 goals in the first 25 games of his career, Huberdeau joins Pittsburgh' Sidney Crosby and Evgeni Malkin, Washington's Alex Ovechkin and Anaheim's Teemu Selanne as the only active players to accomplish the feat.
• If the Sabres trade one of their veteran defensemen, they won't be replacing him by simply calling up Brayden McNabb from Rochester. McNabb suffered a knee injury Saturday at Houston and the Amerks said today he will be out at least four weeks.
• The Panthers announced shortly before the game that captain Ed Jovanovski will have season-ending hip surgery April 5. The veteran defenseman has been limited to six games this season.
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