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1AEAL00286-Mitsubishi Alternator
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Mitsubishi Alternator - 1AEAL002861AEAL00286
Part Details
- Voltage / Wattage / Amperage Rating: 85 Amp
This part replaces:
- Lester 13692
- New
- Brand New, Not Remanufactured Alternator
- 85 Amps
- No core charge
- Direct replacement
- Built to strict quality control standards
This replacement alternator is just what you need to get your vehicle in good working order again. If your battery is no longer being charged completely, or at all, this alternator may be the solution for you.
Lifetime Warranty
This item is backed by a Limited Lifetime Warranty. In the event this item should fail due to manufacturing defects during intended use, we will exchange the part free of charge (excludes shipping charges) for the original purchaser. Please keep your invoice for proof of this warranty.
Vehicle Fit
- 1994-1997 Mitsubishi Montero 85 Amp Alternator
- 1997-2004 Mitsubishi Montero Sport 85 Amp Alternator for V6 3.0L
- 1999-2004 Mitsubishi Montero Sport 85 Amp Alternator for V6 3.5L
Part #: 1AEAL00286
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"Thanks for the fast reliable service. Great price, and the headlights were as good as oem or better!!! Keep up the good work..."- Dwuan M.
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Depending upon flavor, may also contain one or more of the following: organic calendula petals, orange flavor, vanilla flavor, sea salt, organic peppermint, organic coconut, coconut flavor, almond flavor, organic raspberries, raspberry flavor, blackberry flavor.
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Soy: Some of our items with chocolate contain soy lecithin. See ingredients.
Gluten: All of our baked goods are made with organic oat flour, which may be milled in the same facility as wheat flour. Thus, there may be traces of wheat or gluten even though it is not an intended ingredient.
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The Ladies Relief Society would like to send kudos to our schools that donated cans for our Donation Day event: Alta Sierra, Bell Hill Academy, Cottage Hill, Deer Creek, Grass Valley Charter, Lyman Gilmore, Mt. St. Mary's, Nevada Union and Union Hill.
A special thanks to the school staff members who help orchestrate the food drive and make sure the food is delivered to our main event area.
Finally, a special thanks to the Nevada Union FFA and the Grass Valley Charter eighth-graders who volunteered and provided us with great support.
Carol Judd
Member of Grass Valley Ladies Relief Society


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COLUMBIA — He climbed the two steps and sat behind the elevated postgame press conference table, his shoulders sagging in his suit coat, the realities of a dismal week weighing on him.
Frank Martin sighed. He had to know weeks like this would happen, and with 10 regular season games remaining in his first year as South Carolina's basketball coach, he now must determine how to prevent the whole thing from spiraling, like it did last season.
February, the hardest month of the college basketball season, arrived in a bad way Saturday for USC, which lost 67-56 to Georgia, following a 75-36 defeat Wednesday at Florida. The Gamecocks (12-9, 2-6 Southeastern Conference) did very little right last week, leaving them needing to win four of their final 10 games to snap a three-year run of losing regular seasons.
The previous week had gone so well — a six-point loss at Missouri, one of the most frenzied road settings USC will face this season, then a 21-point win over Arkansas, the Gamecocks' biggest margin of victory in an SEC game since 2005-06.
But now, the mess that was the Florida and Georgia games had come and gone, and as Martin tried to make sense of it, he did not mince words.
"I've done just a poor job this past week of getting our guys ready to play," he said to start his press conference. "I've got to do my job a heck of a lot better. My staff's been on me about that, and I'm not going to expand on that."
But he did, sort of.
He blamed himself for USC's shoddy defense Saturday, when Georgia shot 58.1 percent.
"No energy, no discipline, no life," he said. "We were just bad. They caught the ball wherever they wanted it."
He blamed himself for the Gamecocks' "stagnant" offense. Too little ball movement against a long team like Georgia — or Kentucky, which USC visits on Tuesday — is recipe for failure. USC shot 35.8 percent, its fifth-worst showing of the season. Of those five, three have occurred in the past five games, including 31.1 at Florida.
But USC's leader, junior point guard Bruce Ellington, knows the players, particularly himself, have much to do with improving the Gamecocks' offensive flow. The lack of it was evident in USC shooting 32 percent in the second half Saturday, when wing player Michael Carrera scored just one point, on 0-of-3 shooting, after having 15 in the first half, on 5-of-10.
"I've got to start being a more vocal leader on the court and get guys in the right place," Ellington said. "We stand around a lot. If something doesn't work, we just kind of stand."
Martin refused to question his team's effort, which, considering the dearth of talent Martin inherited, is a critical part of its success.
"If I demand that they play with better effort, they'll probably play with better effort," he said. "I allowed them to take a step back this week, and that's not right on my part."
But their lack of fight, for whatever reason, was evident this week in their offensive rebounding numbers. Entering the Florida game, USC had rebounded 45.9 percent of its missed shots. In the Florida and Georgia games combined, USC rebounded just 18 of its 65 misses (27.7 percent).
"Is that their fault?" Martin said. "No, that's my fault, because I haven't paid attention to it. I haven't demanded as much as I need to. We'll fix that. When I don't do my job, I'm a big boy. I look in that mirror and I tell that guy the truth.
"The deeper into the year you go, the harder the games get, so you've got to have an unbelievable amount of courage, of discipline, of toughness, so you can deal with the games. Obviously, this past week, we didn't answer the bell."
USC junior point guard Bruce Ellington (right) had 14 points in the Gamecocks' loss to Georgia on Saturday afternoon.×


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on March 7, 2013 - 12:09 AM
NEWARK, N.J. — Ville Leino was feeling so good Wednesday, he didn't want his first full regular-season practice with his teammates to end. The workout showed that his year could soon start.
Leino, who has yet to play for the Buffalo Sabres this season, skated with vigor in Prudential Center. He hadn't done contact drills with the team since training camp because of a hip injury, but it's healed enough to allow him to envision a return to the lineup.
The forward is aiming for Sunday in Philadelphia against his former Flyers teammates.
"Philly would probably be one of the good options here," Leino said. "I'm having a lot of fun out there. I wish practices would run longer, and that normally doesn't happen during the season. It's pretty exciting."
Leino isn't 100 percent, but he says he's in good shape and should be able to play through any lingering pain.
"It gets a little sore, but hockey players don't really feel well ever, so it's quite fine," he said. "I've been able to do a lot of other stuff other than skating, and my conditioning is good. The oxygen runs pretty good. My lungs are pretty good. I've been [lifting] a lot of weights, so it's pretty good."
Jordan Leopold, who has an upper-body injury, also practiced. The defenseman, who hasn't played since Feb. 17, does not have a timetable for returning.
"It's just not quite there," Leopold said. "Getting close and making progress every day. The good thing is I haven't taken any steps backward."
At least once per season, the debate about making visors mandatory re-ignites. It's happening now after New York Rangers defenseman Marc Staal got hit in the right eye Tuesday night on a shot by Philadelphia defenseman Kimmo Timonen.
The Rangers announced Wednesday night they expect Staal to make a complete recovery.
"The league continues to support a rule that would make visors mandatory in NHL games," Deputy Commissioner Bill Daly said in an email to the New York Times. "It has been the consistent position of the players' association that they are opposed to mandating visor use, that it should be a matter of 'player choice,' and that increased visor use by players should be achieved through continued education and sensitization to the dangers associated with non-use."
The Sabres are a visor-friendly team. Defenseman Robyn Regehr does not wear one — he says sweat dripping on the shield impairs his vision — but 18 members of the Sabres do.
"Does it provide more protection? Yes," Regehr said. "Can sticks still come up and get under it? Yes, I've seen that, too, so by no means is it going to take away all injuries that way. But it is going to provide a little bit more protection."
New Jersey coach Pete DeBoer said goaltender Johan Hedberg will start against the Sabres tonight. Hedberg gave up three goals on 11 shots before being pulled during the second period of the Devils' 5-2 loss to Tampa Bay on Tuesday.
The Devils returned tough guy Cam Janssen to the minors on Wednesday, so the Sabres likely won't need to dress enforcer John Scott. Interim coach Ron Rolston used the same forward lines and defense combinations in practice that he used Tuesday during the 4-3 loss to Carolina.
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Top Definition
Useless. As would be a bag of pants, not fulfilling their function, but just hanging around in a bag.
"Sorry we haven't got any."
"Well that's just a bag of pants, isn't it."
"Well that's just a bag of pants, isn't it."
от Fridgemagnet 18 юни 2005
Trending Now
Can you define these popular missing words?
Someone disposed to wearing his low-riders at knee level thus completely revealing both underwear and outerwear.
I wonder if that bag of pants is wearing a thong?
от dreadsocks 22 юли 2005


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Bachelor of Business Administration
You are a responsible adult: motivated, disciplined, ready and eager to move ahead in the business world. You've acquired knowledge, skills, and abilities in the workplace, but you need a bachelor's degree to demonstrate you're ready to take your career to the next level. The Bachelor of Business Administration (BBA) degree at Westminster College is a great option for adults who want to complete their degree at a fully accredited college that is also top-ranked by USNews & World Report and the Princeton Review.
Westminster's BBA is an online, project-based degree completion program designed for working professionals. It's based on the premise that the true mark of learning is not just what you know but what you can do with what you know. Our low residency program gives you the opportunity to accelerate the completion of your degree and offers unique features you won't find anywhere else:
This innovative, affordable business degree program offers a whole new way to learn through a series of projects that build on what you already know. With a multi-media learning environment enriched by face-to-face faculty coaching, you'll learn at your own pace with an array of online learning resources. Ultimately, you'll demonstrate mastery of more than 40 business competencies-the skills that employers are looking for today.


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Who's going to get a $5 million recording contract?
The X Factor's season 2 finale got underway Wednesday night with the finalists performing three songs each – including a duet with a music superstar.
Britney Spears's contestant, Carly Rose Sonenclar, has been a favorite, trading the No. 1 spot with her fellow finalist, L.A. Reid's country singer Tate Stevens, through out the competition.
Carly first reprised "Feeling Good," and sang it better than the first time she performed it during her audition, according to judge Simon Cowell. "It's shocking how bright your star is," Spears said. She performed her duet with Leann Rimes, singing the country star's hit, "How Do I Live." Her final performance – of Leonard Cohen's "Hallelujah" – had the judges gushing. "You looked like an angel," Demi Lovato said. "You sang like a ridiculously talented angel."
Tate, the competition's only country singer, first performed "Anything Goes" by Randy Houser. "I'm still obsessed with you," Demi said. Added Simon, "You are made in America. You are authentic." For his duet, he sang Little Big Town's cheeky party anthem, "Pontoon." And for his final performance in the competition, Tate sang Chris Young's "Tomorrow." "In a year's time," Simon said, "We're going to be hearing about your record sales."
"I'm almost crying because I realize it's the last time I'm going to see you perform on that stage," Demi said.
Simon's remaining act, girl group Fifth Harmony, may have had their best night yet in the competition, beginning with "Anything Can Happen." L.A. called it "magical," adding that they're "the one to beat." Britney said the colorful performance was "spectacular, girly and fun." Their duet, with The X Factor's own Demi Lovato, of "Give Your Heart a Break" was a highlight of the night.
"These girls are so easy to work with," the judge said. "They're so down to earth, so sweet and I love you guys. This was so much fun."
Their last song, "Let It Be" by the Beatles, proved how much the five members have "blossomed as a group," Britney said. Admitting his bias, their mentor Simon said, based on their performances on Wednesday, the girls of Fifth Harmony "deserve to win the competition."
Do you agree? Or is Tate or Carly your choice for the big prize? Tell us in the comments below.
The winner will be revealed Thursday in a two-hour show that will include a performance by One Direction.
The X Factor: Finalists Sing for Votes One Last Time
Ray Mickshaw/FOX


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WAILUKU - A Paia man is serving a six-month jail term after being convicted of drunken driving four times in the past six years.
"You're lucky you didn't kill yourself," 2nd Circuit Judge Rhonda Loo told Moris Uwekoolani. "You're very fortunate you didn't kill an innocent person in a car or on the sidewalk."
Uwekoolani, 33, also was placed on five years' probation as part of his sentence Wednesday.
He had pleaded no contest to habitually driving under the influence of alcohol. The felony charge can be brought when someone is arrested for DUI after having three prior convictions within 10 years.
"What is troubling here is the repeated pattern of conduct," said Deputy Prosecutor Mark Simonds.
He said Uwekoolani had prior convictions for drunken driving in 2007, 2009 and 2011 when a police officer saw Uwekoolani stumble off a moped at 11:10 p.m. Aug. 12. He threw down or dropped a 40-ounce liquor bottle, Simonds said.
"This is an individual who should not have been on the roadway to begin with," he said. "He wasn't licensed."
Deputy Public Defender William "Pili" McGrath said Uwekoolani had graduated from three treatment programs and may need to attend a fourth.
"It may be easier to stop driving than stop drinking," McGrath said. "It seems likely it will be a while before this man will be able to legally operate a vehicle."
McGrath asked the judge to consider suspending a jail term for Uwekoolani.
But Simonds argued for a three-month jail term, the longest the prosecution could seek under terms of a plea agreement, "to drive home the seriousness of his conduct."
In imposing the sentence, Loo said Uwekoolani went though intensive outpatient treatment after each of his previous DUI convictions.
"What did you learn? Obviously you did not learn because you're back here," she told Uwekoolani.
She said Uwekoolani admitted to being an alcoholic but "never gave any thought about quitting."
He reported not attending 12-step programs because he didn't believe in them, Loo said.
"All these DUIs and you haven't learned your lesson," she told Uwekoolani.
He was ordered to pay a $1,500 fine and not consume alcohol or illegal drugs.
Uwekoolani's license was revoked for five years.
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Is your child's backpack too heavy?
Published On: Aug 28 2013 12:00:00 AM CDT Updated On: Aug 28 2013 05:00:00 AM CDTSorry, Flash is not supported.
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Having worked the charity shops in the U.K. for a number of years - I am convinced that the amount of quality finds here is most definitely now 'down' on what it was a year or so back, and when they find a good piece the price does escalate, and it's now almost as cheap to rummage around in bottom end antiques shops.
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Lab DirectorDr. Murat KarabulutPhone: (956) 882-7236
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TripAdvisor ratingRead reviews
Waldorf Hilton
An iconic hotel, situated in London's Theatre district, 5 minutes' walk from Covent Garden. Enjoy a fabulous fine-dining experience at the Homage Grand Salon restaurant.
Visit top London attractions within a mile radius of this central London hotel including the London Eye and Trafalgar Square or enjoy a play or musical at one of Lonndon's renowned theaters.
Guest rooms are tastefully furnished in a contemporary style and feature a plasma screen television, high-speed internet access, a safe to hold your laptop and complimentary hot and cold beverages. Upgrade to a Deluxe Room or choose an Executive Room for Executive Lounge access.
Indulge in a spot of Afternoon Tea in the Grand Palm Court and choose pastries from the patisserie. Enjoy the finest European cuisine at the Homage Grand Salon restaurant. Set against a dramatic backdrop of gold-cast Ionic pillars and striking objets d'art, the atmosphere is extremely stylish.
Relax in the hotel's 14-metre heated indoor pool or work out in the LA Fitness club on cardiovascular equipment and weights. Then unwind in the sauna and steam room.
Accommodation details
United Kingdom
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Room types and facilities
Sleeps 2, Bed Type: Double(s) In Room Movies, Bathtub/shower combination, Private bathroom, Trouser/Pant press, Satellite television, Air conditioning, Minibar, Television
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- 1 Pool
- Coffee shop
- Elevators
- Exercise gym
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- Hair dryer
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- Business center
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• Good Godfrey's Bar and Lounge - lunch and afternoon tea
• Homage Grand Salon - modern-European cuisine.
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on January 25, 2013 - 10:01 PM
, updated January 26, 2013 at 9:55 AM
Some serious softball here
Erie County legislators, still basking in the glow of their 22-15 win over Team Poloncarz on the softball field last year, are already talking rematch.
"We should never pass up an opportunity to humiliate the county executive and his staff," said coach Kevin Hardwick, a Town of Tonawanda lawmaker.
County Executive Mark Poloncarz has said he hired his staff for their "brain power" rather than athleticism. Still, lawmakers see a path to victory for Poloncarz, with his deal to keep the Buffalo Bills in Orchard Park.
"Coach mentioned that if the county executive wants to be competitive in this year's softball game, maybe he can get some individuals from the Bills' front office to join him," said Legislator Timothy Hogues of Buffalo.
Deputy County Executive Richard Tobe replied, "We were actually thinking some Bills from not the front office."
Gaga over Gosling
Like thousands of movie fans, Sarah Velasquez has a crush on Ryan Gosling.
But she is the only one who can say she got his famous mug on a coffee mug.
Velasquez, a buffalo.com blogger, saw an interview in which the Canadian-born Gosling – now starring in the film "Gangster Squad" – said it was his dream to have his face on a Tim Hortons coffee mug, like the "Dick Tracy" Burger King cups he collected in his youth. Velasquez, whose two favorite Southern Ontario imports are Gosling and Tim Hortons, created her own Gosling travel mug with an assist from co-worker Kathryn Przybyla. She posted a photo of it on buffalo.com and emailed the link to Tim Hortons.
The coffee and doughnut giant loved it, made an actual mug and sent one to Gosling and another one to Velasquez, and posted it on Twitter. Her story has been widely reported in Canada.
After a phone interview with CTV on Friday, Velasquez jokingly agreed she has become an international celebrity. And she knows how she wants the story to end.
"He is taking me on a date to Tim Hortons," she said. "He owes me."
Schumer ducks out of menu
The next time Sen. Charles E. Schumer takes a turn as menu planner, he may want to, well, duck.
The New York Democrat served as party planner for President Obama's Second Inauguration, including the luncheon in the Capitol.
With Schumer's help, the chef built a menu around New York products, including maple syrup, cheese and the apples in the pie. But after testing a main course of Long Island duck, they looked elsewhere for the entree.
"We were going to have Long Island duck. The duck was very good, but the preparation wasn't great. We settled on South Dakota bison," Schumer told the New York Times.
That comment ruffled the feathers of Long Island caterer Butch Yamali.
"The duck is the symbol of Long Island," Yamali told the Washington Post. "When you attack the duck, you're attacking Long Island. You're attacking almost three million people by taking the duck off the menu."
Schumer, of course, could have easily averted this controversy.
"At the very least he could have gone with Buffalo wings," noted Post columnist Dana Milbank.
He's buffaloing us, right?
Speaking of wings, a Chicago Tribune columnist is looking for a lawyer to file a class-action lawsuit against Buffalo Wild Wings.
Why? The company's signature offering contains no buffalo meat whatsoever, Eric Zorn writes.
Zorn says he's inspired by lawsuits against the parent company of Subway because the sandwich chain's "foot-long" subs are not a full 12 inches in length.
"It turns out that 'buffalo' in the dish 'buffalo wings' refers not to bison, the low-fat beef substitute, but to Buffalo, N.Y., where small, deep-fried chicken parts were first served as bar food," he writes. "I may have been aware of this fact, though I'm willing to swear to my ignorance, confusion, dismay, outrage, pain and suffering if doing so stands to let me in on a share of the jury award."
By Patrick Lakamp with contributions from Denise Jewell Gee, Bruce Andriatch and Jerry Zremski.


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Rick Owens
long tank
Out of stock
Unfortunately this item is out of stock
Pearl cotton long tank from Rick Owens featuring a sleeveless design and a curved hem.
Made in Italy
Designer Style ID: RU14S1150MR
Farfetch ID: 10632463
Models Measurements
- Composition:
- Cotton 100%
Your order will be shipped directly from the boutique to you. Farfetch ships worldwide, and you will be able to track your order at any time. The cost of shipping your order will be calculated at the checkout.
Import duties information
Delivery duties are included in the item price when shipping to all EU countries plus USA, Canada, China, Australia, Puerto Rico, Switzerland, Singapore, Republic Of Korea, Kuwait, Qatar, India, Norway, Saudi Arabia, Taiwan, Thailand, U.A.E., Japan.This means all import duties are included in your order, so the price you see is the price you pay. You will not receive an additional duty bill from the courier to receive your shipment. If you are ordering from within your own customs zone or country, import duties will not be applicable anyway, however you may have to pay VAT or local Sales Taxes where applicable (for the UK and USA these are included at the checkout).
Delivery duties are not included in the item price when shipping to all other countries. This means you may be liable to pay import duties on receipt of your order.
Free returns pick-up
You have 14 days from receiving your order to return the item to the boutique using our free returns pick-up service. We strongly recommend that you book your free returns pick-up within 7 days of receiving your order to ensure that it arrives back to the boutique in time. Please note for standard orders we can only collect returns from the same country to which your order was delivered. For click and collect orders we can collect your return from the country your order was delivered to and also the country of the original boutique you ordered from. Click here to read our full returns policy.
Dark romance and broken beauty fill the collections of Rick Owens, the LA-born master of glamorous grunge (or 'glunge' as he calls it). His collections of wearable luxury combined with a rock'n'roll attitude has attracted celebrity fans such as Rihanna, Nicole Richie and Madonna.
Degli Effetti Men
Rome , Italy
'The boundary between fashion and art is imperceptible,' says Massimo Degli Effetti, the owner. 'But while art can work alone, the fashion designer is the starting point of a long journey.' Together with his assistant, Effetti seeks out the unusual, with an eye for counter-current styles that defy convention.


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on October 20, 2012 - 12:11 AM
The negotiations between the NHL and its players' association are becoming increasingly nasty. The anger and distrust have risen on both sides.
The stories of Craig Leopold and Proposal Three help explain why.
In the spring, Leopold bemoaned the league's financial system. The owner of the Minnesota Wild said exorbitant player salaries were preventing him from making a profit.
In the summer, Leopold committed $196 million to two players, Ryan Suter and Zach Parise.
Now that it's fall, Leopold represents the league in collective bargaining talks and helps present proposals that could trim the salaries of Suter and Parise by 12 percent before they even play a game for the Wild.
It's no wonder players are angry.
"When people ask for money, they usually say, 'Give me your money or I'm going to hurt you,'" Phoenix captain Shane Doan said. "They don't say, 'Give me your money and I'm going to hurt you.' That's kind of the point we joke about, but that's where we're at."
The owners are ticked off, too. They feel the players' union has yet to stray from its original proposal and is "misrepresenting" its new ones.
The NHLPA made three offers Thursday in the latest round of failed talks, then vocally bemoaned the fact the league spent just 10 minutes looking them over. Proposal Three is probably why the rejections came quickly.
Donald Fehr, the union's executive director, publicly explained "we haven't been able to run the numbers yet" but the offer was along the lines of the 50-50 revenue split the league proposed.
"We think it makes a lot of sense," Fehr said. "We think it really is fair. It couldn't be more balanced."
According to the NHL, the proposal was actually between 56-44 and 57-43 in favor of the players.
"The proposal contemplates paying the players approximately $650 million outside of the players' share," Deputy Commissioner Bill Daly said. "In effect, the union is proposing to change the accounting rules to be able to say '50-50,' when in reality it is not. The union told us that they had not yet 'run the numbers.' We did."
It's no wonder there's distrust.
It's also no wonder the NHL canceled more games Friday and is days away from canceling a huge chunk more, including the Winter Classic.
The league, which previously canceled games from Oct. 11 to Oct. 24, has axed all games through Nov. 1. Four more contests for the Buffalo Sabres - Friday in New Jersey, Oct. 28 at home against Philadelphia, Oct. 30 in Boston and Nov. 1 against Phoenix in First Niagara Center - are gone, bringing the total to nine.
If a new collective bargaining agreement isn't reached by Thursday - the league's deadline to start an 82-game season Nov. 2 - a larger portion of the schedule is expected to disappear. That could include the New Year's Day Winter Classic between Toronto and Detroit, scheduled to be played in 110,000-seat Michigan Stadium.
"My understanding is at some point in the not-too-distant future, we will have to commit many millions of dollars if we're going to play the Winter Classic on Jan. 1," Commissioner Gary Bettman said. "Obviously, under these circumstances and all the uncertainty, we're not going to commit many millions of dollars if we don't think we're going to have a deal. The Winter Classic time frame, in terms of making that decision, is probably rapidly approaching."
Each side has one non-negotiable item on its agenda. The NHL wants a 50-50 split, preferably immediately. The NHLPA wants players to get every dollar in their previously signed contracts.
According to Globe and Mail reporter James Mirtle, who has a background in statistical analysis, it's impossible to have both. So the stalemate continues .
"At some point, this process has to get moved along," Bettman said. "The next step is hopefully we'll hear back, but I don't know what the next step is. I'm obviously very discouraged."
Said Fehr: "When somebody takes a hard stand like the owners have taken, you have to assume they mean it. You go from there, but it doesn't mean you make an agreement that is not in the interest or consistent in the desires of the players."
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Project Unlike: The Facebook Screener
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on March 21, 2013 - 12:49 PM
A judge has backed the state Cemetery Board's determination that Amigone Funeral Home cannot move its cremation operation on Sheridan Drive in the Town of Tonawanda to another location.
Amigone and Sheridan Park Inc., its nonprofit crematory, filed a petition earlier this year in State Supreme Court after the Cemetery Board said such a move would violate the Anti-Combination Law of 1998. The state law bans funeral home and cemetery/crematory combinations. The law, enacted seven years after Sheridan Park began its operations at 2600 Sheridan Drive, allowed already-existing crematory and funeral home arrangements.
Last summer, the funeral home asked the state if it would approve relocation of the crematory. The state said no.
The law's grandfather clause extends only to the crematory in operation at the time the law took effect; it does not extend to any new location, state officials said.
"This court cannot say that the board's determination is without sound basis in reason, lacks rationality or is taken without regard to the facts," Supreme Court Justice John A. Michalek said in court Thursday in dismissing the funeral home's petition. "This court cannot substitute its own judgment for that of the administrative agency unless the decision clearly appears to be arbitrary or contrary to law."
The petition was filed against the state Division of Cemeteries and the Cemetery Board and its members.
Attorney Robert E. Knoer, who represented Amigone, was not available for comment after the ruling. In the petition, he argued the Cemetery Board made an error in interpreting the Anti-Combination Law.
"The law was specifically aimed at preventing future business combinations and was not meant to affect the number or location of crematories themselves," Knoer said. "The act was not meant to address where or even how many cremations were performed. The exemption in the law was meant to exempt the existing business combinations, not the physical location."
Michalek, however, said the language of the law's exemption "does indeed support the board's determination."
Sheridan Park operated the crematory for more than 20 years at the same location.
Last summer, the New York State Attorney General's Office threatened to bring a civil suit to shut down the crematory, according to the petition. The state cited neighbors' complaints about noise and odors.
Sheridan Park then began the process of relocating the crematory to a less densely populated area, according to the petition, and agreed to cease operations for six months, through Jan. 22, during which time it would secure an alternative location, according to the petition.
After finding a possible new location on Cooper Avenue, in an industrial zone, Sheridan Park sought permission from the Cemetery Board to move operations there.
The business arrangement between Amigone and Sheridan Park at the new location would have been the same as the one now in place at the Sheridan Drive location, and the new crematory would have similar facilities.
Nearby residents of Two Mile Creek Road, which runs parallel to Cooper, opposed the site. Sheridan Park last fall cited neighborhood and state opposition in withdrawing its request for permission to move to a building on Cooper Avenue.
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Five Honored on Academic All-MAC Football Team
Five student-athletes have received Academic All-Mid-American Conference honors, including first-team selections Zane Fakes and Jacob Richard.
In addition, Steven Bell, Joel Cox and Nick Miles each received honorable mention on the Academic All-MAC Team.
The Academic All-MAC honor is for a student-athlete who has excelled in athletics and academics. To qualify, a student-athlete must have at least a 3.20 cumulative grade-point average and have participated in at least 50 percent of the contests for that particular sport. First-year students and junior college transfers in their first year of residence are not eligible for the award.
Fakes and Richard are both receiving the honor for a second straight season.
Fakes, who was named a 2013 Capital One Academic All-American, was also named to the All-MAC First Team as a senior tight end. He managed 41 receptions for 410yards and two touchdowns. Fakes earned his bachelor's degree from Ball State last May and spent the fall pursuing his master's degree. Fakes owned a 3.687 GPA on Ball State's 4.0 scale.
Richard, a sophomore offensive lineman for the Cardinals in 2013, was part of an offensive line that blocked for record setting seasons by Keith Wenning (quarterback), Willie Snead (wide receiver) and Jahwan Edwards (running back). He helped Ball State rank 17th in the nation for fewest sacks allowed with an average of 1.23 per game.
The Cardinals, under the direction of head coach Pete Lembo, tallied a 10-3 overall record in 2013 and appeared in the GoDaddy Bowl, marking the school's second straight bowl appearance. The 10 wins marked only third time in the school's 89 years of football a team has posted at least 10 victories in a single season. The back-to-back bowl games marks only the second time for that to occur in the school's history, while the seven MAC wins marked only the fifth time to reach that number since joining the league in 1975.


text:
Tepper isn't going out. Why not? His explanations tend to be rather literal: the indisputable fact, for instance, that he has 20 minutes left on the meter.
Tepper's behavior sometimes irritates the people who want his spot. ("Is that where you live? Is that car rent-controlled?") It also irritates the mayor - Frank Ducavelli, known in tabloid headlines as Il Duce - who sees Murray Tepper as a harbinger of what His Honor always calls "the forces of disorder."
But once New Yorkers become aware of Tepper, some of them begin to suspect that he knows something they don't know. And an ever-increasing number of them are willing to line up for the opportunity to sit in his car with him and find out.
Tepper Isn't Going Out is a wise and witty story of an ordinary man who, perhaps innocently, changes the world around him.
Executive Producer: Sherry Huber
Director: Sherry Huber
Producer: Louis Milgrom
©2001 Calvin Trillin
(P)2001 Random House, Inc.
"Trillin is a highly accomplished storyteller as well as a humorist and a memoirist, and this oddly titled novel is by far his funniest and sunniest yet." (Publishers Weekly)
"By dint of Trillin's fertile and humorous imagination, the book emerges as a refreshing and completely likable jape." (Library Journal)
"Dog Stopping Funny"
I walk dogs while I listen and I was laughing so loudly that my dogs kept stopping and turning around to see what had gotten into me. I tried to explain it to them but I don't think they ever understood. What a hoot this book is.
I loved listening to books during my commute to work. Maybe I shouldn't have retired!
"Constantly entertaining"
Very funny. As a former New Yorker I enjoyed every minute of it.
"To park or not to park..."
Simply one of the most entertaining books I have read or listened to this year. Mr. Trillum delivery is dry but laced with humor and grace as he explores the ordinary life of Tepper as it turns very extraordinary by the most unusual of circumstances. His acerbic wit casts its gaze on all aspects of our modern life - work, family, politics and much more. Tis a book to curl up with in any convenient parking spot and enjoy.
After reading all the reviews touting how humorous this book was, I must admit, I'm quite disappointed. I didn't "laugh out loud" or even giggle. I equate this book to reading a human interest story in the newspaper; you read it, for a moment think,"hmm okay interesting" then you move on. The ending left me wondering "that's it?" Though the descriptions of the city area are quite good and whisked me away to NYC, they do not make up for the weak storyline. Perhaps this is a book you should read only when you are circling the West Side looking for a parking spot.
"Calvin Trillin at His Best!"
Charming and subtle story that provides insights into life in America's busiest city. A one-of-a- kind book with a surprising conclusion.
"kansas city meets new york city"
what are the midwestern male virtues ?
stoicism / dependability / humility
being useful in the face of adversity
and the virtues of new york jewish males ?
shrewd / shrill / clever / read the fine print
unruffled in the face of adversity
who could possibly have a foot in both worlds ?
well his name is calvin " call me bud " trillin
he has written a small humble shrewd book to prove it
the main character lives life on this own terms
the world wants to press him into its' mold
he resists in a stubborn thoughtful way
the book is a parable for grown men
it is a primer on how to live an authentic life
trillin tells you the hard truth with a sly wink
"a droll portrait of NYC - ya jerky bastard, ya!"
This ambling tale moves leisurely but sharply through the landscape of New York cranks, politicians, idiosyncratic regulations, and the inanity of fame. Tepper is an affable eccentric with one obsession: parking. The response of NYC to his outre behaviour moves the story along.
I enjoyed every moment of this whimsical reading, and wish Trillin's dry delivery were available for all his books, starting with "American Fried!"
"Great Listen"
This is the funniest laugh out loud book I have read since Confederacy of Dunces. You can see every character in the book as if they were in your living room.
"Good Book - Lousy Listen"
I thought I'd enjoy listening to the author reading his book - I've listened to him on Public Radio and enjoyed him immensely - read some of his other works and enjoyed those.
His voice is enjoyable for about 20 minutes and then I just could not listen to him anymore. His voice just can't keep me interested for longer than about 15 minutes.
I tried - I really tried, but I'm getting the book to read and keep my listening to Mr Trillin on the radio.
"Very funny but not the best reader"
... Or I guess I should say "I've heard better." I am a big fan of Mr. Trillin's writing, and have read most of his non-fiction over the years. He's a funny man, and a good writer.
That being said, there are a couple of flaws that make me not so fond of the audiobook. The first is that his reading is rather bland, and does not do his prose justice. Most authors should leave reading to the professionals, and Mr. Trillin is unfortunately one of them. The second is that the prose itself suffers from that characteristic flaw of first-time novelists who have been writing for many years: Many of the jokes and themes have appeared many times in his earlier work. (If you've heard the phrase 'sabbath gasbag' before, you'll be in my boat.) This detracts somewhat from the enjoyment. Though it evokes the same nostalgia one feels for the city that the rest of the book does, it's not so pleasant in the ideas of the book as opposed to the milieu.
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text:
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od uživatele Russ W. 18. srpen 2007


text:
Summary: Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like
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Bcl-2 family Edit Wikipedia article
|Apoptosis regulator proteins, Bcl-2 family
Structure of human Bcl-xL, an inhibitor of programmed cell death.[1]
|OPM superfamily
|OPM protein
|Bcl-2 homology region 4
rat bcl-xl an apoptosis inhibitory protein
Apoptosis regulator Bcl-2 is a family of evolutionarily related proteins. These proteins govern mitochondrial outer membrane permeabilization (MOMP) and can be either pro-apoptotic (Bax, BAD, Bak and Bok among others) or anti-apoptotic (including Bcl-2 proper, Bcl-xL, and Bcl-w, among an assortment of others). There are a total of 25 genes in the Bcl-2 family known to date.
Active cell suicide (apoptosis) is induced by events such as growth factor withdrawal and toxins. It is controlled by regulators, which have either an inhibitory effect on programmed cell death (anti-apoptotic) or block the protective effect of inhibitors (pro-apoptotic).[2][3] Many viruses have found a way of countering defensive apoptosis by encoding their own anti-apoptosis genes preventing their target-cells from dying too soon.
There are a number of theories concerning how the Bcl-2 gene family exert their pro- or anti-apoptotic effect. An important one states that this is achieved by activation or inactivation of an inner mitochondrial permeability transition pore, which is involved in the regulation of matrix Ca2+, pH, and voltage. It is also thought that some Bcl-2 family proteins can induce (pro-apoptotic members) or inhibit (anti-apoptotic members) the release of cytochrome c into the cytosol which, once there, activates caspase-9 and caspase-3, leading to apoptosis. Although Zamzami et al. suggest that the release of cytochrome c is indirectly mediated by the PT pore on the inner mitochondrial membrane,[4] strong evidence suggest an earlier implication of the MAC pore on the outer membrane.[5][6]
Another theory suggests that Rho proteins play a role in Bcl-2, Mcl-1 and Bid activation. Rho inhibition reduces the expression of anti-apoptotic Bcl-2 and Mcl-1 proteins and increases protein levels of pro-apoptotic Bid but had no effect on Bax or FLIP levels. Rho inhibition induces caspase-9 and caspase-3-dependent apoptosis of cultured human endothelial cells.[7]
Site of action
The site of action for the Bcl-2 family is mostly on the outer mitochondrial membrane. Within the mitochondria are apoptogenic factors (cytochrome c, Smac/Diablo homolog, Omi) that if released activate the executioners of apoptosis, the caspases.[8] Depending on their function, once activated, Bcl-2 proteins either promote the release of these factors, or keep them sequestered in the mitochondria. Whereas the activated pro-apoptotic Bak and/or Bax would form MAC and mediate the release of cytochrome c, the anti-apoptotic Bcl-2 would block it, possibly through inhibition of Bax and/or Bak.[9]
The Bcl-2 family has a general structure that consists of a hydrophobic helix surrounded by amphipathic helices. Many members of the family have transmembrane domains.
The members of the Bcl-2 family share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains (named BH1, BH2, BH3 and BH4) (see the figure D on the left). The BH domains are known to be crucial for function, as deletion of these domains via molecular cloning affects survival/apoptosis rates. The anti-apoptotic Bcl-2 proteins, such as Bcl-2 and Bcl-xL, conserve all four BH domains. The BH domains also serve to subdivide the pro-apoptotic Bcl-2 proteins into those with several BH domains (e.g. Bax and Bak) or those proteins that have only the BH3 domain (e.g. Bim Bid, and BAD).
All proteins belonging to the Bcl-2 family[11] contain either a BH1, BH2, BH3 or BH4 domain. All anti-apoptotic proteins contain BH1 and BH2 domains, some of them contain an additional N-terminal BH4 domain (Bcl-2, Bcl-x(L), Bcl-w), which is also seen in some pro-apoptotic proteins like Bcl-x(S), Diva, Bok-L and Bok-S. On the other hand, all pro-apoptotic proteins contain a BH3 domain necessary for dimerization with other proteins of Bcl-2 family and crucial for their killing activity, some of them also contain BH1 and BH2 domains (Bax, Bak). The BH3 domain is also present in some anti-apoptotic protein, such as Bcl-2 or Bcl-x(L).
BH3-only family
The BH3-only subset of the Bcl-2 family of proteins contain only a single BH3-domain. The BH3-only members play a key role in promoting apoptosis. The BH3-only family members are Bim, Bid, BAD and others. Various apoptotic stimuli induce expression and/or activation of specific BH3-only family members, which translocate to the mitochondria and initiate Bax/Bak-dependent apoptosis.[12]
Proteins that are known to contain these domains include vertebrate Bcl-2 (alpha and beta isoforms) and Bcl-x (isoforms Bcl-x(L) and Bcl-x(S)); mammalian proteins Bax and Bak; mouse protein Bid; Xenopus laevis proteins Xr1 and Xr11; human induced myeloid leukemia cell differentiation protein MCL1 and Caenorhabditis elegans protein ced-9.
Human genes encoding proteins that belong to this family include:
See also
- Bcl-2 inhibitor, anti-cancer drugs targeted at this family of proteins
- The BCL-2 Database, the reference database on BCL-2 proteins
- ^ Muchmore SW, Sattler M, Liang H, et al. (May 1996). "X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death". Nature 381 (6580): 335–41. doi:10.1038/381335a0. PMID 8692274.
- ^ Vaux DL (1993). "A boom time for necrobiology". Curr. Biol. 3 (12): 877–878. doi:10.1016/0960-9822(93)90223-B. PMID 15335822.
- ^ Milliman CL, Korsmeyer SJ, Wang K, Yin XM, Chao DT (1996). "BID: a novel BH3 domain-only death agonist". Genes Dev. 10 (22): 2859–2869. doi:10.1101/gad.10.22.2859. PMID 8918887.
- ^ Zamzami N, Brenner C, Marzo I, Susin SA, Kroemer G (April 1998). "Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins". Oncogene 16 (17): 2265–82. doi:10.1038/sj.onc.1201989. PMID 9619836.
- ^ Kinnally KW, Antonsson B (May 2007). "A tale of two mitochondrial channels, MAC and PTP, in apoptosis". Apoptosis 12 (5): 857–68. doi:10.1007/s10495-007-0722-z. PMID 17294079.
- ^ Martinez-Caballero S, Dejean LM, Jonas EA, Kinnally KW (June 2005). "The role of the mitochondrial apoptosis induced channel MAC in cytochrome c release". J. Bioenerg. Biomembr. 37 (3): 155–64. doi:10.1007/s10863-005-6570-z. PMID 16167172.
- ^ Hippenstiel S, Schmeck B, N'Guessan PD, Seybold J, Krüll M, Preissner K, Eichel-Streiber CV, Suttorp N (October 2002). "Rho protein inactivation induced apoptosis of cultured human endothelial cells". Am. J. Physiol. Lung Cell Mol. Physiol. 283 (4): L830–8. doi:10.1152/ajplung.00467.2001. PMID 12225960.
- ^ Fesik SW, Shi Y (2001). "Controlling the caspases". Science 294 (5546): 1477–1478. doi:10.1126/science.1062236. PMID 11711663.
- ^ Dejean LM, Martinez-Caballero S, Manon S, Kinnally KW (February 2006). "Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins". Biochim. Biophys. Acta 1762 (2): 191–201. doi:10.1016/j.bbadis.2005.07.002. PMID 16055309.
- ^ Chao DT, Korsmeyer SJ (1998). "BCL-2 family: regulators of cell death". Annu. Rev. Immunol. 16: 395–419. doi:10.1146/annurev.immunol.16.1.395. PMID 9597135.
- ^ Reed JC, Zha H, Aime-Sempe C, Takayama S, Wang HG (1996). "Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death". Adv. Exp. Med. Biol. 406: 99–112. doi:10.1007/978-1-4899-0274-0_10. PMID 8910675.
- ^ Michael Kastan; Abeloff, Martin D.; Armitage, James O.; Niederhuber, John E. (2008). Abeloff's clinical oncology (4th ed.). Philadelphia: Churchill Livingstone/Elsevier. ISBN 0-443-06694-9.
This article incorporates text from the public domain Pfam and InterPro IPR000712
This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.
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Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like Provide feedback
PF02180. Bcl-2_3 is a small family of eukaryotic proteins associated with autophagy. The family is found in association with PF00452.
Literature references
Cruz-Reyes J, Tata JR;, Gene. 1995;158:171-179.: Cloning, characterization and expression of two Xenopus bcl-2-like cell-survival genes. PUBMED:7607538 EPMC:7607538
Ku B, Woo JS, Liang C, Lee KH, Hong HS, E X, Kim KS, Jung JU, Oh BH;, PLoS Pathog. 2008;4:e25.: Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68. PUBMED:18248095 EPMC:18248095
Internal database links
|Similarity to PfamA using HHSearch:
This tab holds annotation information from the InterPro database.
InterPro entry IPR029450
Some herpesviruses encode homologues of the antiapoptotic, cellular Bcl-2 to promote viral replication and pathogenesis. Members of this small group of viral proteins are homologues of Bcl-2 and seem to inhibit autophagy through binding to autophagy effector Beclin1 [PUBMED:18797192].
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
The graphic that is shown by default represents the longest sequence with a given architecture. Each row contains the following information:
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Pfam Clan
This family is a member of clan BCLiA (CL0551), which has the following description:
This superfamily is characterised by families of proteins that inhibit apoptosis, They are regulated by all BH3-only proteins to promote apoptosis.
The clan contains the following 5 members:APG6 Atg14 Bcl-2 Bcl-2_3 BID
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
There are various ways to view or download the sequence alignments that we store. We provide several sequence viewers and a plain-text Stockholm-format file for download.
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We make a range of alignments for each Pfam-A family:
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- the alignment generated by searching the sequence database using the HMM
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- UniProt
- alignment generated by searching the UniProtKB sequence database using the family HMM
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- meta
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
|Representative proteomes
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
Format an alignment
Download options
We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
|Representative proteomes
|Raw Stockholm
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
If you find these logos useful in your own work, please consider citing the following article:
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
|Seed source:
|Previous IDs:
|Coggill P
|Number in seed:
|Number in full:
|Average length of the domain:
|0.00 aa
|Average identity of full alignment:
|0 %
|Average coverage of the sequence by the domain:
|0.00 %
HMM information
|HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
|Model details:
|Model length:
|Family (HMM) version:
|download the raw HMM for this family
Species distribution
Sunburst controlsHide
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|Other sequences
|Unclassified sequence
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
This chart is a modified "sunburst" visualisation of the species tree for this family. It shows each node in the tree as a separate arc, arranged radially with the superkingdoms at the centre and the species arrayed around the outermost ring.
How the sunburst is generated
The tree is built by considering the taxonomic lineage of each sequence that has a match to this family. For each node in the resulting tree, we draw an arc in the sunburst. The radius of the arc, its distance from the root node at the centre of the sunburst, shows the taxonomic level ("superkingdom", "kingdom", etc). The length of the arc represents either the number of sequences represented at a given level, or the number of species that are found beneath the node in the tree. The weighting scheme can be changed using the sunburst controls.
In order to reduce the complexity of the representation, we reduce the number of taxonomic levels that we show. We consider only the following eight major taxonomic levels:
- superkingdom
- kingdom
- phylum
- class
- order
- family
- genus
- species
Colouring and labels
Segments of the tree are coloured approximately according to their superkingdom. For example, archeal branches are coloured with shades of orange, eukaryotes in shades of purple, etc. The colour assignments are shown under the sunburst controls. Where space allows, the name of the taxonomic level will be written on the arc itself.
As you move your mouse across the sunburst, the current node will be highlighted. In the top section of the controls panel we show a summary of the lineage of the currently highlighed node. If you pause over an arc, a tooltip will be shown, giving the name of the taxonomic level in the title and a summary of the number of sequences and species below that node in the tree.
Anomalies in the taxonomy tree
There are some situations that the sunburst tree cannot easily handle and for which we have work-arounds in place.
Missing taxonomic levels
Some species in the taxonomic tree may not have one or more of the main eight levels that we display. For example, Bos taurus is not assigned an order in the NCBI taxonomic tree. In such cases we mark the omitted level with, for example, "No order", in both the tooltip and the lineage summary.
Unmapped species names
The tree is built by looking at each sequence in the full alignment for the family. We take the name of the species given by UniProt and try to map that to the full taxonomic tree from NCBI. In some cases, the name chosen by UniProt does not map to any node in the NCBI tree, perhaps because the chosen name is listed as a synonym or a misspelling in the NCBI taxonomy.
So that these nodes are not simply omitted from the sunburst tree, we group them together in a separate branch (or segment of the sunburst tree). Since we cannot determine the lineage for these unmapped species, we show all levels between the superkingdom and the species as "uncategorised".
Since we reduce the species tree to only the eight main taxonomic levels, sequences that are mapped to the sub-species level in the tree would not normally be shown. Rather than leave out these species, we map them instead to their parent species. So, for example, for sequences belonging to one of the Vibrio cholerae sub-species in the NCBI taxonomy, we show them instead as belonging to the species Vibrio cholerae.
Too many species/sequences
For large species trees, you may see blank regions in the outer layers of the sunburst. These occur when there are large numbers of arcs to be drawn in a small space. If an arc is less than approximately one pixel wide, it will not be drawn and the space will be left blank. You may still be able to get some information about the species in that region by moving your mouse across the area, but since each arc will be very small, it will be difficult to accurately locate a particular species.
Tree controlsHide
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- Save a text representation
Selected sequences
- (Uncheck all)
- graphically
- as an alignment
- sequence accessions
- sequences in FASTA format
The tree shows the occurrence of this domain across different species. More...
Species trees
We show the species tree in one of two ways. For smaller trees we try to show an interactive representation, which allows you to select specific nodes in the tree and view them as an alignment or as a set of Pfam domain graphics.
Unfortunately we have found that there are problems viewing the interactive tree when the it becomes larger than a certain limit. Furthermore, we have found that Internet Explorer can become unresponsive when viewing some trees, regardless of their size. We therefore show a text representation of the species tree when the size is above a certain limit or if you are using Internet Explorer to view the site.
If you are using IE you can still load the interactive tree by clicking the "Generate interactive tree" button, but please be aware of the potential problems that the interactive species tree can cause.
Interactive tree
For all of the domain matches in a full alignment, we count the number that are found on all sequences in the alignment. This total is shown in the purple box.
We also count the number of unique sequences on which each domain is found, which is shown in green. Note that a domain may appear multiple times on the same sequence, leading to the difference between these two numbers.
Finally, we group sequences from the same organism according to the NCBI code that is assigned by UniProt, allowing us to count the number of distinct sequences on which the domain is found. This value is shown in the pink boxes.
We use the NCBI species tree to group organisms according to their taxonomy and this forms the structure of the displayed tree. Note that in some cases the trees are too large (have too many nodes) to allow us to build an interactive tree, but in most cases you can still view the tree in a plain text, non-interactive representation. Those species which are represented in the seed alignment for this domain are highlighted.
You can use the tree controls to manipulate how the interactive tree is displayed:
- show/hide the summary boxes
- highlight species that are represented in the seed alignment
- expand/collapse the tree or expand it to a given depth
- select a sub-tree or a set of species within the tree and view them graphically or as an alignment
- save a plain text representation of the tree
Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.
There are 2 interactions for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.


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on February 14, 2013 - 12:01 AM
, updated February 15, 2013 at 12:23 AM
Drew Stafford's goal is to stay upbeat. So far, it's the only goal he's got.
Stafford is in the worst slump of his career. The drought has come when the Buffalo Sabres could really use his help. As the team dwells near the basement of the NHL, Stafford has a zero in the goal column.
In a twist, the doughnut is eating him. The right winger is saying all the right things, but it's obvious the lack of production weighs heavily. It's evident in his body language and the forced grin mixed with grimace that accompanies his words.
"It's hard not to let the negativity creep in there, the body language," Stafford said Thursday. "It's tough, but you've got to nip it in the bud right away and get back to work. That's what I've been trying to do."
Stafford has gone 17 games without a goal, including all 14 this season, as the Sabres welcome Boston back to First Niagara Center tonight. It's really nothing new. He's had plenty of droughts in his seven-year career. He's gone five games or more without a goal 25 times, including 16- and 15-game slumps in 2008-09.
Last season, he had six disappearing acts. He suffered through a 13-game famine from November to December and also experienced three seven-game slides, a six-gamer and one five-game drought.
It's likely none have been as frustrating as this one.
The 27-year-old alternate captain hoped he was past this type of thing. So did the Sabres, who gave him a four-year, $16 million deal prior to last season.
"I'm just trying to stick with it, stay positive and continue to work," Stafford said. "It's one of those things where if you continue to get frustrated, let negativity creep into your game, creep into your life, it makes it that much harder. It's obviously very difficult, especially when you're losing as well."
Stafford's frustration came to the forefront Tuesday during Buffalo's 2-0 loss in Ottawa. He called for the puck on an odd-man rush, received a perfect cross-ice pass, looked at the empty net ... and fanned on the shot.
Stafford paused in disbelief and muttered to himself before following the play to the other end. After the whistle, he slowly trudged to the bench. Once he arrived, he put his head down on the boards in anguish.
"It's been how many games, you know?" he said with a shoulder shrug and pained smile. "It's frustrating. That's a golden opportunity, golden chance."
Stafford has had plenty of chances. He has 40 shots, which put him in the top 30 in the NHL entering Thursday's schedule. Everyone in the top 65 had scored, except him.
"It's tough, obviously, the situation that he's in," linemate Marcus Foligno said. "He's all around the net. There's no shortage of that. When he gets one, I'm sure there'll be plenty more coming after it."
Tyler Ennis, the center for Stafford and Foligno, says he's impressed by the right winger's effort and positive attitude. Like Foligno, Ennis sees one goal leading to more.
Now it's up to Stafford to see it. He spent the team's off day Wednesday with his fiancée and their dog, just trying to forget about hockey and slumps. He hopes the recharge time will allow his brain to clear.
"It's the hardest thing in the world, but it's part of the job," Stafford said. "It's part of being a professional hockey player. You have to deal with stuff like that.
"You can't show up to the rink the next day and be moping around because that just brings everyone else down. It's times like these that a good thing I like to say is, 'The game reveals your character.'
"Good or bad, you always have to make sure that you're always having the right attitude because guys feed off that. The streak that I'm on here that I haven't scored, if I'm moping around the locker room that's just bringing other guys down. It's part of my role, as well, as a leader on this team to bring that attitude and bring that work habit where I have to show up and continue to get better."
email: firstname.lastname@example.com
Drew Stafford has had many goal-less slumps during his seven-year career, but he's in the midst of his longest ever.
Games Dates
17 April 3, 2012 – present
16 Feb. 6 – April 3, 2010
15 Nov. 28 – Dec. 26, 2009
13 Nov. 5 – Dec. 3, 2011
11 Oct. 25 – Nov. 26, 2008


text:
Top Definition
A boring town in Herefordshire, England. It is really shit and there is nothing to do except get drunk and mess around. The town is full of inbreds, chavs and idiots.
Person 1: Have you ever been to Ledbury?
Person 2: Yeah, it's a complete shithole.
Person 2: Yeah, it's a complete shithole.
door Wahs Sirhc 26 april 2010
Trending Now
Can you define these popular missing words?


text:
St. Ambrose University Digital Collections
Describe your collection for visitors to your site.
The Catich Collection provides digital access to the artwork of Fr. Edward Catich (1906-1979). Fr. Catich, one of the world's finest calligraphers, was known as an internatinoal authority on stone incising, typography, and stained glass fabrication, and as the foremost authority on the Roman alphabet, its origin, nature, and …
The Bettendorf Company was a manufacturer of railroad cars in the early 1920s. As a way to reward long-term employees, the Company initiated the Loyalty Club in 1922. The Loyalty Club was made up of men who had been employees of the Bettendorf Company for fifteen or more years. The Car Journal was published monthly by the Loyalty …
The Pacem In Terris Peace and Freedom Award was established in 1964 and was named for Pope John XXIII's encyclical and given to those who exemplified its principles. Fr. Jack Smith, a graduate of St. Ambrose College and a member of its History faculty, was one of the founding members of the Catholic Interracial Council and was …
Describe your collection for visitors to your site.
St. Ambrose University has come a long way since it began as a seminary and school of commerce for young men in 1882. Over more than a century, the campus grew, and with it the services to ensure our students, faculty and staff have the best environment in which to learn, live, and work. The St. Ambrose University Digital Collections document some of the highlights from the past century and provide an opportunity for today's students to learn about the past.


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EAST PALESTINE - The family-owned dealership on East Martin Street targeted for relocation to state Route 14 will remain on East Martin.
Village Solicitor Shirley Smith told Village Council on Monday they needed to make a decision regarding the project.
"It doesn't look like it's feasible to move forward at this point," she said.
The village became involved at the close of 2011 after Brittain Motors owner Tom Brittain requested the property be annexed into East Palestine in order to keep his business in town.
He said that doing so would improve the village's tax base and create and retain jobs.
The roughly 10 acres along state Route 14 in Unity Township is owned by Brittain and is not being used for anything at this point.
The dealership has operated on East Martin Street since 1925 and the move to state Route 14 was to meet a General Motors requirement that all dealerships be relocated or refurbished.
Council approved the annexation and also approved seeking public funding to extend water and sewer service to the site. The extension was last estimated to cost around $740,000, and the village would have been eligible for grant funding on the basis that the project would create and retain jobs.
The project earned the approval of county commissioners last year as well, but was halted because of a state franchise law prohibiting dealerships from relocating within 10 miles of another dealership offering the same line of automobiles without that dealership's approval.
Brittain was notified in June 2012 that Dave Flynn, owner of Columbiana Buick-Cadillac-Chevrolet Co., would not sign off on the move.
Since then village officials have been looking for other ways to move the project forward, but Smith said that it doesn't seem to be possible.
Brittain said on Monday he continues to hope he can relocate to state Route 14, but that won't happen until approval is granted from the Columbiana dealership.
"There's nothing I can do about that at this point. I will continue to hope that it will be resolved," he said.
Meeting the GM requirement has also not been resolved yet, he said.
Either way, he thinks the village should continue working to move utilities to state Route 14, with or without him.
"I'd love to see the whole city limits moved north ... I think it's the greatest thing in the world for East Palestine," he said.
But extending utilities to that area isn't possible without grant funding, which is something that would have been available as long as Brittain Motors was involved.
Councilman Alan Cohen said, and Finance Director Traci Thompson confirmed, that the village just doesn't have the money to provide those services to that area on its own.
"Do we want to be out on state Route 14? Sure. Is it something that is probably going to happen? I don't know," he said.
Cohen added that bringing outside property into town is also difficult when the affected residents don't approve.
"Last spring or summer we had a discussion on the annexation issue and a majority of people don't want to be annexed," he said.
Council approved a first reading of legislation that could cancel the project. Two more readings are required before a vote.
Council will then need to repeal the previous legislation allowing the utility extension. That legislation was passed on March 12, 2012, Smith said.


text:
Top Definition
As long as you're still searching for Chin, you've already found him
de Anonymous 06 Iunie 2003
Trending Now
Can you define these popular missing words?
A great respectable person. A dude with charisma. Neither human nor animal, a superior being.
Man that new kid is so wonton animal chin!! I'm sure he's going to be captain for the football team.
de Phillip Brown 15 Ianuarie 2003


text:
on December 5, 2012 - 8:28 PM
LOCKPORT – The driver whose speeding car smashed into a tree on the Tuscarora Indian Reservation on Aug. 19, inflicting fatal injuries on a passenger, was given a plea offer Wednesday and was told to return to Niagara County Court Jan. 2 to take it or face possible indictment.
Pierce L. Abrams, 21, of Printup Road on the reservation, was offered a chance to plead guilty to second-degree vehicular manslaughter and misdemeanor driving while intoxicated. The charges would carry a maximum seven-year prison term, Deputy District Attorney Theodore A. Brenner said.
"We're considering it," said defense attorney Joel L. Daniels, who asked County Judge Sara Sheldon Farkas for the four-week delay. Farkas ordered Abrams to surrender his driver's license and allowed him to remain free on his own recognizance.
Lewiston police reported that Abrams' 2008 four-door Suzuki was speeding west on Mount Hope Road just east of Green Road at about 4:45 a.m. Aug. 19. The vehicle crossed the road, struck a ditch, a culvert and a small boulder, and became airborne before striking the tree and overturning. Passenger Kyle Atkins, 22, of the reservation, died of his injuries Aug. 24 in Erie County Medical Center.


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But that was before she stopped settling.
"I hate the sensation that you have when you get home and you think, 'I'm a coward. I didn't speak up. I didn't defend myself. I didn't say no,' " she told PEOPLE while promoting Guardians of the Galaxy on Saturday. "I wanted to please others more than I wanted to please myself, and I [would] find myself embarrassed to look in the mirror."
Saldana, 36, added: "I promised myself, by my own will, that I'm not going to do it anymore."
Proof she is, indeed, staying true to those words: her marriage to Marco Perego, whom she wed last summer.
"We found each other, and it was that desire and not that necessity that put us together," said Saldana, who has not commented on speculation that she's now pregnant.
Her profound confidence comes from embracing her 30s, Saldana said.
"I'm where I wanted to be when I would look at myself and say, 'I just have a feeling that it's going to get better, that I'm going to find who I truly am more and more, and I'm going to stick to that road,' " she said. "I'm very happy that it happened before I met him, because I didn't want somebody to give me the answers that I should find for myself."
But Perego did give Saldana a symbol of everlasting love when he tattooed her face on his arm. "It was the most romantic thing! I didn't stop him, but I did sort of try to talk him out of it," she said. "I've done crazier things than that, and I'm pretty sure he has, too."


text:
Dirty Looks launches On Location 2013 with first venue portrait and Curator announce
Dirty Looks: On Location
Opening July 1 | 7PM – 12AM
The Spectrum | 59 Montrose Avenue | Brooklyn, NY 11206
All events... Read more
Incentives! DL ROADSHOW 2013! 2-Year anniversary!
If you've yet to receive an incentive for your loving contribution to DL: On Location - FEAR NOT!
The silkscreening elves have been working overtime preparing the final shipments for... Read more
Full Line-up announcement + Opening Event + June Dirty Looks!
Hello all,
Thank you, again, so SO much for helping us to meet our goal!
We are thrilled to announce the FULL LINE-UP for Dirty Looks: On Location! Starting... Read more
Final 24 Hours + Preliminary Artist List + New Venue Portrait
We are in our final day of our fundraising push with 15% to go. Please share information about our project via Facebook, Twitter or whatever social media suits you. Everyone's... Read more
Flawless Sabrina's Apartment + Final Push
Take a look at our newest Venue Portrait - Flawless Sabrina's Apartment. Jack Doroshow, aka Sabrina was the MC at the pageant documented in The Queen, the first... Read more
Over 40% Funded + ONE WEEK LEFT + Heathers event
Thank you everyone for pushing us over 40%!! It is truly overwhelming that in just over two weeks we have reached nearly 100 supporters! But we need your continued help... Read more
First Venue Portrait + New Artwork + over $2,000 in our first week!
Thank you everyone for the strong start to our Dirty Looks: On Location fundraising initiative! We are excited to launch the next stage in the Dirty Looks: On Location campaign.... Read more


text:
The battle between cops and gangsters heats up in this brand new trailer for TNT's Mob City (premiering Wednesday, Dec. 4 at 9/8c). Acclaimed Walking Dead executive producer/director Frank Darabont explores the world of 1940's Los Angeles in this noir thriller, which also stars Dead alums Jon Bernthal and Jeffrey DeMunn. The series focuses on real-life accounts of the City of Angel's violent criminal underworld, featuring infamous mob figures such as Mickey Cohen and Bugsy Siegel. And judging by the number of bullet-ridden bodies and bloodied faces in the trailer, the show pulls no punches with its realism.
The trailer will be screened at New York Comic Con on Saturday, in a panel moderated by TV Guide Magazine president/editor-in-chief Debra Birnbaum.
Subscribe to TV Guide Magazine now!
View original First Look: All Hell Breaks Loose in Trailer for TNT's Mob City at TVGuide.com
Other Links From TVGuide.com
Location, ST | website.com


text:
Financial Data Warehouse Sub-Recipient Report: FY 2011-12 Distributions by Vendor
Note: You can use the alphabetical list below to limit the list of districts by first letter.
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Please click on your district name below to access the 2011/12 Sub-Recipient Report in PDF format.
- Bayfield, La Plata
- Bennett 29J, Adams
- Bethune R-5, Kit Carson
- Big Sandy 100J, Elbert
- Boulder Valley RE 2, Boulder
- Branson Reorganized 82, Las Animas
- Briggsdale RE10, Weld
- Brighton 27J, Adams
- Brush RE-2 (J), Morgan
- Buena Vista R-31, Chaffee
- Buffalo RE-4, Logan
- Burlington RE-6J, Kit Carson
- Byers 32J, Arapahoe
Note: These documents are made available in the Adobe Acrobat PDF format. Acrobat allows the user to view and print the documents exactly as they look in hard copy. First-time users of this format will have to perform a one-time only installation of the free Adobe Acrobat Reader Software before they will be able to read or print a document. This format is used extensively on the Web and on this site, in particular.
For additional information please contact Adam Williams at: email@example.com or 303.866.6843


text:
on November 15, 2012 - 12:02 AM
, updated November 15, 2012 at 8:18 AM
In discussing how the Buffalo Bills cope with losing AFC East games so often, center Eric Wood evoked the definition of insanity.
"It's tough," Wood said. "We've struggled in the division, and it hurts us.
"You just go back and go to work and try to come up with a different game plan next time. You can't just keep repeating the same mistakes or things that have gotten you beat in the past."
The Bills enter Thursday night's game against the Miami Dolphins in Ralph Wilson Stadium on an eight-game losing streak in the division. They've dropped all three of their AFC East matchups this year, including Sunday's heartbreaking defeat to the New England Patriots.
A team's goal every season is to win its division because that's the only way to guarantee a playoff berth.
But the Bills continue to stumble against their most important opponents. They're 2-13 in the division since Chan Gailey became coach, 3-13 with Ryan Fitzpatrick as the starting quarterback and 23-56 since the Bills last went to the playoffs.
It has driven the fans crazy.
"It's frustrating," Bills receiver Stevie Johnson said. "We talk a lot about turning the corner and trying to be that team.
"We got a great team in this locker room. You look at it on paper and all that, and it is great. But we're still getting losses. It's time to turn it around."
While it's understandable for one team to have your number in any league, the Bills are routinely victimized by all three of their AFC East opponents.
The Bills have losing records against each rival from 2000 onward (including 0-4 vs. the Colts before divisions were realigned after the 2001 season). Gailey never has beaten the New York Jets and is 1-5 against the Patriots. His best divisional record is 1-3 against the Dolphins.
This year's expectations have made the losses sting even more. The Bills spent big money to acquire defensive end Mario Williams, signed defensive end Mark Anderson away from the Patriots and drafted cornerback Stephon Gilmore in the first round to cope with Tom Brady.
They haven't closed the gap.
"We've made moves the past couple years to shore up games in the division, and it hasn't quite worked out yet," Wood said.
Rather than compete for the AFC East title as they'd hoped, the Bills must win both remaining games against the Dolphins and beat the Jets in their rematch merely to break even in the division this year.
Hall of Fame outside linebacker Andre Tippett knows both ends of the spectrum. The Patriots drafted Tippett in 1982, and they went to the playoffs three times in his first five seasons, reaching the Super Bowl once.
Then the Patriots walked into that AFC East buzz saw of the late '80s and early '90s. In a division loaded with superstar quarterbacks, the Patriots went through seven dark seasons in which they averaged six victories.
"You all go through training camp thinking, 'This is going to be the year,' " Tippett said Wednesday. "We go through the draft and some minicamps and then July comes around and you're looking at your team with the goal of 'Let's win our division first, and then we'll see what happens from there.' "
Tippett then laughed at the thought of how those Patriots teams fared despite their lofty aspirations.
"Knowing that we had to play Dan Marino and Kenny O'Brien and Jim Kelly and that whole group," Tippett said, "and it's, like, 'How do you get around all this stuff? How do we pull it together?'
"You don't. You've got to figure out a way to keep up. You had to go into each one of those games and play like there was no tomorrow because you couldn't even split with those guys."
That the Bills' 12-year playoff drought is taking place during the Patriots' ongoing reign of dominance under Bill Belichick isn't a total coincidence. No AFC East team has had a better record than the Pats since 2000.
The Dolphins and Jets, however, have had their opportunities despite rebuilding multiple times.
Miami won the AFC East on a tiebreaker in 2008 and has been to the playoffs three times with two head coaches since Buffalo stopped going. New York has been to the playoffs six times with three head coaches in that stretch.
Miami and New York each has posted four seasons with double-digit victories since Buffalo's last playoff berth. Buffalo has had zero.
Based on win percentage and margin of victory, the Bills actually have gotten worse in AFC East games the past few years. Gailey has the worst divisional record of Buffalo's 21st century head coaches.
Gregg Williams won 22.7 percent of his divisional games, losing by an average of six points. Mike Mularkey had the most success at 41.7 percent, losing by an average of three points.
Dick Jauron won 38.1 percent of the time and lost by an average of five points.
Gailey has won 13.3 percent of his AFC East games. The average score has been 34-19.
"Any time you're playing someone in the division you get a little extra cranked up because you know how much they mean," Wood said. "To have had such poor production, it's deflating. ... It's something we definitely need to change in a hurry if we're going to move forward."
email: firstname.lastname@example.com


text:
Braeburn Model 2220NC Multistage Programmable Thermostat
About This Thermostat
|Yes (5+2)
|System Compatibility:
|Multi-Stage, Heat Pump
|Power Options:
|Heat/Cool Changeover:
|Programmable Fan:
|Temperature Limits:
|Keypad Lockout:
|Vacation Hold:
Braeburn Model 2220NC Multistage Programmable Thermostat
The digital programmable thermostat shall be a Braeburn model number 2220NC, 3.62" high x 4.72" wide x 1.38" deep, powered independently with either 24 Volt AC or with two "AA" alkaline batteries (3.0 Volt DC). The thermostat shall be compatible with multi-stage conventional systems with up to two stages of heating and one stage of cooling and heat pump systems with one compressor and up to one auxiliary stage. The thermostat shall have a bright blue backlight display and separate sub-base for trouble free installation. Temperature control range shall be between 45� and 90� F (7� and 32� C), accuracy of +/- 1� F (+/- .5� C), humidity range between 5% and 95% relative humidity. The thermostat shall include non-volatile memory to retain user settings, adjustable temperature limits, filter check monitor, adaptive recovery mode (ARMT), separate heating and cooling set point program times and temperatures, and auxiliary heat indicator. Thermostat shall have low battery indication and a front reset button will return user settings to default values when pressed. The thermostat can be mounted to a horizontal junction box. Meets California Title 24 Guidelines.
. Large 2 Sq. In. Display with Bright Blue Backlight
. 5-2 Day Programming
. Programmable Extended Hold Mode
. Tamper-Proof Adjustable Temperature Limits
. Hardwire or Battery Powered
. Permanent Memory Retains Settings
. Separate O & B Terminals
. Compressor Short Cycle Protection
. Adjustable Temperature Differential
. Low Battery Indication
. ESD Guard Electronic Circuitry Control
. Front Access Reset Button
. F� / C� Switch
. Gas / Electric Fan Switch
. Mount to Horizontal Box
Dimensions: 3.62" x 4.72" x 1.38"
Electric Rating: 24 Volt AC (18-30 Volt AC)
1 amp maximum load per terminal
3 amp total maximum load (all terminals)
AC Power: 18-30 Volt AC
DC Power: 3.0 Volts DC
(2 "AA" Alkaline batteries included)
Compatibility: Single stage gas, oil or electric systems
Single stage heat pump systems
250mv - 750mv millivolt heating systems
Control Range: 45� to 90� F (7� to 32� C)
Display Range: 40� to 99� F (5� to 37� C)
Accuracy: +/- 1� F (+/- .5� C)
Differential: .5�, 1�, or 2� F (.25�, .5�, or 1� C
Storage Temperature: 14� to 140� F (-10� to 60� C)
Operating Humidity: 5% to 95% Relative Humidity
Terminations: Rc, Rh, O, B, Y1, W1, G, C


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Universal fit parts fit a range of vehicles, and may or may not fit your current bike without modification.
Exact fit parts are designed specifically for your 2007 Harley Davidson Softail Springer CVO/SE FXSTSSE.
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