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A school program where students help other students. It helps kids across a school get to know each other. It breaks barriers and encourages everyone to be open and less judgmental. This is a program that could truly change how the world works.
Share Your Story saved my life
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June Hobart
Sept. 2, 1947-Nov. 2, 2012
Age: 65
Residence: Greeley
June Hobart, 65, of Greeley, died Friday, Nov. 2, 2012, at McKee Medical Center in Loveland after courageously battling illnesses for several years. June was born in Chicago on Sept. 2, 1947.
June was preceded in death by her mother, Florence, and father, Charles. She is survived and will be greatly missed by her brother, Don, as she will be missed by many close friends. She was a champion for animal rights and would appreciate memorial contributions in her name made to the Weld County Humane Society or W.O.L.F. Sanctuary in LaPorte, Colo.
No memorial services are planned.
Melvin Ocken
Jan. 21, 1932-Nov. 3, 2012
Age: 80
Residence: Holyoke, Colo.
Melvin Ocken was born Jan. 21, 1932, and died Nov. 3, 2012, in Holyoke, Colo.
Melvin graduated from York, Neb., High School in 1950. Melvin married Betty Naber June 22, 1952. They have four children.
Melvin farmed his entire life, was a member of Zion Lutheran and was an original organizer for American Cancer Society's Relay For Life in Holyoke. Because of this, Melvin was recognized as Holyoke Citizen of the Year.
Survivors are wife, Betty; children, Deb (Dan) Austin, Jim (Vicki) Ocken, Cindy (Tony) Burton and Steve Ocken; 11 grandchildren, including Jordan (Diana) Austin and Lindsey (Jason) Garey; and other family and friends.
Arthur Lee Meyer
Sept. 21, 1929-Nov. 1, 2012
Age: 83
Residence: Buckeye, Ariz. (formerly of Greeley)
Arthur Lee Meyer, 83, a former Greeley resident, died Nov. 1, 2012, in Arizona. He was born to Alvin and Martha Meyer on Sept. 21, 1929, in Armour, S.D.
After serving as a communications officer in the Air Force, Art settled in Greeley in 1968. He worked in a variety of positions for the Pepsi-Cola company, promoting to vice president for distribution in northern Colorado. He retired in 1986, then started his own beverage distribution business and later sold wireless Internet service.
Art married Patricia Conrad in 1974. They moved to Arizona in 2005. In addition to Patricia, Art is survived by his daughter, Teri (Steve) Raml of Glendale, Ariz.; stepdaughter, Cory (Nick) Parino of Liberty, Mo.; stepsons, Perry (Eileen) Pollet of Denver and Chris (Evelyn) Conrad of Price, Utah; his brother, Darryl (Mary Jean) Meyer of Donna, Texas; along with eight grandchildren and two great-grandchildren.
He was preceded in death by his parents and his brother, Wayne.
A memorial service for Arthur will be held in Greeley in the near future.
Carolyn Perdue
June 18, 1938-Nov. 6, 2012
Age: 74
Residence: Lawrence, Kan.
Carolyn Jean (Mitchell) Perdue, 74, of Lawrence, Kan., passed away Nov. 6, 2012, at Bonell Good Samaritan Community in Greeley.
She was born June 18, 1938, in Denver.
She is survived by three sons, Rick (Jane) Perdue of Lawrence, Kan., Terry (Tammy) Perdue and Gary Perdue, both of Greeley.
Visitation will be from 4-6 p.m. Friday, Nov. 9, 2012, at Adamson Chapel. Graveside Funeral Service will be at 1 p.m., Saturday, Nov. 10, 2012, at Mount View Cemetery in Bennett.
Condolences may be sent to the family and her life story read at www.adamsonchapels.com.
Bert Oram Thomas Jr.
Oct. 6, 1956-Nov. 3, 2012
Age: 56
Residence: Greeley
Bert Oram Thomas Jr., 56, of Greeley, died Saturday, Nov. 3, 2012, at his home. Bert was born Oct. 6, 1956, in Minneapolis, Minn., to Bert Oram Thomas Sr. and Betty LaVonne (McDonald) Thomas.
Bert moved to Greeley in 1959, where his father taught at CSC, now UNC. He attended College High (University High) graduating in 1975. After high school, he attended Aims Community College. Later he attended UNC.
On March 18, 1978, he married Brenda Olin at the Platteville United Methodist Church. They were members of the Faith Lutheran Church in Johnstown.
Bert owned and operated Thomas Advertising Specialties. He worked for Safeway in Longmont and Greeley for 33½ years. He was still working at Thomas Advertising Specialties and at Sprouts at the time of his passing.
Bert loved his chocolate Labrador dogs. He was an avid fisherman and loved his family, especially his grandchildren. He never missed his sons' and grandchildren's events: football, baseball, soccer, T-ball, choir concerts, plays, volleyball and any other activities.
Bert is survived by his wife, Brenda of Greeley; two sons, Bryson Thomas (Sarah) of Greeley and Bradyn Thomas (Rachel) of Johnstown; his father, Bert O. Thomas Sr. of Greeley; mother-in-law, Shirley A. Olin of Platteville; sister, Barbara Butler (Dwight) of College Station, Texas; and four grandchildren, Shawn Marie LeBlanc and Jackson Thomas, both of Greeley and Ellasyn Thomas and Avery Thomas, both of Johnstown.
Bert was preceded in death by an infant daughter; his mother; and his father-in-law, Ray E. Olin.
Friends may visit from 5-7 p.m., Thursday at Stoddard Funeral Home. Celebration of life will be at 1 p.m. Friday at Faith Lutheran Church in Johnstown, 3999 West South 1st St. Cremation.
In lieu of flowers, memorial contributions may be made to the Weld County Humane Society in care of Stoddard Funeral Home, 3205 28th St., Greeley, CO 80634.
Please go to www.stoddardsunset.com to sign an online guest book.


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Ivy and I are taking a friend -Keli!- to the train station this morning and I wish we'd spent more than just a morning together this weekend while she stayed with Erin. At least we'll have the long ride (and hopefully a quick detour to the beach) before she goes!
I took this photo during a summer playdate with Meagan and Jennifer. We picked them up at the train stop and Jennifer was wearing her sweet girl in the Ergo. (She's also working on her fifth book- you can see her anthology here.) Oh, and she spoke to her daughter only in French. I was insanely inspired.
It's International Babywearing Week. Have a favorite babywearing photo you'd like to send me? I am going to try to post something special this week! I'll also be posting an awesome babywearing giveaway later today. See past I love the way your wear your baby photos.
Check out my post Adventures In Babywearing 2.0 and scroll down for my tips and suggestions. Feel free to leave questions in the comments here or email me as well.
Have a blog? Would love to have you join the babywearing bloggers blogroll. If you get a chance, "like" thebabywearing bloggers blogroll on facebook so others can know to join, too.


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Thursday, April 11, 2013
The Flowertown Festival went off smoothly, but not entirely without a hitch, neighbors told Town Council on Wednesday.
Peter Gorman, who lives on the east side of the park, said the town's decision to close streets on the west side of Main Street pushed more traffic and parking to the east side.
People were continually circling looking for parking spots, and some parked perpendicular instead of parallel, meaning they went past the right-of-way and encroached on private property, he said.
There was also a lot of litter because people discarded items as they returned to their cars, he said.
He was told the litter would be picked up, but when it was still there Tuesday afternoon he and the neighbors banded together to pick it up, he said.
He suggested trash barrels on the paths out of the festival, as well as within the festival itself.
Samuel Green, chairman of the finance committee at Wesley United Methodist Church, said church members were blocked from going down Pressley Avenue to get to church.
Pressley Avenue is a short street that joins the intersection of Sumter Avenue and West 5th St. North. The church is at the end of the street, and its educational building is on West 5th St. North next to the town's Berry House.
Green said police officers were inconsistent about letting people through. Some wouldn't let anyone through, and churchgoers had to pay to park in the First Baptist Church lot, he said.
Even the preacher couldn't get through on Saturday, he said.
Also, the officers wouldn't let people drive down West 5th South St. to the education building, so those who could get down Pressley Avenue had to drive over the grass to get to the education building, he said.
Police Chief Bruce Owens approached Green after the meeting so he could get more information and improve the situation next year.
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Click a question below to view the answer.
He/she has been convicted of a qualifying sexual offense in Florida or another jurisdiction. Qualifying Adult Convictions include:
He/she has been released from or is currently serving parole, probation, or incarceration for a qualifying sex offense (listed above) on or after October 1, 1997;OR
He/she establishes or maintains a residence (permanent, temporary, or transient) in Florida and has a requirement to register or would have a requirement to register as a sexual offender in another jurisdiction;OR
He/she was adjudicated delinquent on or after July 1, 2007, for one of the following offenses and was 14 years of age or older at the time of the offense:
What are the basic registration obligations of sexual offenders/predators?
Registrants are required to report to their local sheriff's office (for a list of locations click here) and provide information including but not limited to:
Note: This information is a public record unless exempt or confidential pursuant to Chapter 119, F.S.
Sexual offenders must complete a registration form at their county sheriff's office either twice a year (birth month and every 6th month thereafter) or four times a year (birth month and every 3rd month thereafter) depending upon their offense. For a list of qualifying offenses for quarterly registration please refer to Florida Statute 943.0435(14)(b).
Sexual predators, some sexual offenders, and juvenile sexual offenders must report four times a year (birth month and every 3rd month thereafter).
Sexual offenders/predators must update their driver license or identification card within 48 hours after any change to their residence (permanent, temporary, or transient) or name.
Sexual offenders/predators MUST maintain registration for the duration of their life.
All qualifying sexual offenders, sexual predators, and juvenile sexual offenders will be listed on the public registry website.
Note: this is a partial list of responsibilities; please refer to Florida Statutes 775.21 and 943.0435 for a complete listing of registration obligations. Top
How often is the Florida Sexual Offender/Predator Registry updated?
The public registry website is updated on a "real-time", continuous basis as new information is received from FDLE's criminal justice partner agencies. Top
Juvenile sexual offenders are required to register in Florida if he/she:
Yes, federal and state laws require sexual offenders/predators to register in all jurisdictions in which they live, work, or go to school.Sexual offenders/predators who are required to register with a temporary address in Florida are subject to all Florida registration laws while the offender/predator is residing within the state, including being listed on the Florida Sexual Offender/Predator Public Registry website (please note that the information is not removed from the website when the sexual offender/predator leaves the state of Florida, and removal from another state's registration requirement does not guarantee removal from the requirement to register in Florida).
Yes, if offenders or predators are visiting from another state he/she must report in person to the sheriff's office within 48 hours of establishing a temporary residence in Florida. He/she is required to report within 48 hours from the time of his/her registration with the sheriff's office to report in person to the Department of Highway Safety and Motor Vehicles (DHSMV) with a copy of the completed sexual offender/predator registration form to obtain a valid Florida identification card or driver's license. Failure to comply with these registration requirements as provided by Florida statute is a felony of the 3rd degree. Top
Florida Statute 943.04354, "Removal of the requirement to register as a sexual offender or sexual predator under certain circumstances" is commonly referred to as the "Romeo & Juliet" law. This law allows certain offenders who specifically meet the criteria of the statute to petition the court for relief from the requirement to register as a sexual offender/predator. Several criteria are specified including: the victim in the case was at least 13 and not more than 17 years of age, is no more than four years younger than the offender, and the sexual activity was consensual. The qualifying offense must be the only sex crime on the offender's record requiring registration. Please see the complete statutory text (F.S. 943.04354) for further details. Top
How can I receive more information about predators/offenders?
FDLE is authorized to post registered sexual offenders/predators via the public website. The FDLE website lists sexual offender/predator flyers which include a photo, designation, status, a physical description of the offender/predator, crime information, and a registered address.
Searches may be conducted by area (city, county and/or zip code), by name,university/campus or E-mail/Internet Identifier. To conduct a search, click on the red Offender Search button at the top of the site.
Citizens may also sign up for email notification using the Florida Offender Alert System. The emails are sent when a sexual offender/predator moves within a certain distance from a specified location set by the citizen or when a particular sexual offender/predator moves anywhere throughout the state of Florida. Click on the yellow Offender Alert System button at the top of the site to sign up.
A Florida criminal history for an individual may be obtained through the FDLE website (www.fdle.state.fl.us) for a fee. Click on the Request a Criminal History button approximately halfway down the page.
To obtain details regarding a specific crime that occurred in Florida, contact the Office of the Clerk of Courts in the county in which the subject was convicted. The county of conviction is listed on the offender/predator registry flyer. Clicking on the county link provided will open a new window with all Florida Clerk of Court websites.
To obtain details regarding an arrest in Florida, contact the local arresting law enforcement agency. Top
How do I report information regarding a sexual offender or a sexual crime?
If you have reason to believe that a sexual crime has occurred or you have been a victim of sexual abuse, please immediately contact the local sheriff's office or police department where the crime occurred (http://offender.fdle.state.fl.us/offender/Links.jsp).
If the crime relates to use of the Internet, such as in cases of child pornography or solicitation of a child over the Internet, please contact the Florida Computer Crime Center at (850) 410-7400 or via e-mail at firstname.lastname@example.com.
If you have information that a registered sex offender is not living at his/her registered address, please contact the local law enforcement agency as soon as possible. Top
Does Florida have a civil commitment law?
Yes, please see the Jimmy Ryce Civil Commitment Act (F.S 394.910-394.932) for specific statutory language regarding civil commitment. Top
Where can I find information about sexual offender/predator residency restrictions?
Florida's sexual offender/predator registration laws do not prohibit offenders/predators from living in certain areas or from sharing a residence with another sexual offender/predator. However, there may be municipal and/or county ordinances that outline where sexual offenders/predators can live, who they can or cannot come in contact with, or what areas in a community they can or cannot be near or visit. Contact your law enforcement agency to obtain this information. For more information pertaining to residency restrictions please see Florida Statute 775.215.
Florida's sexual offender/predator registration laws do not prohibit a sexual offender/predator from living with a child or minor based solely on the individual's requirement to register. However, if an offender/predator is currently under supervision he or she may have specific guidelines/restrictions set by a judge. This information can be obtained by contacting Department of Corrections or Department of Juvenile Justice directly. Top
Can a sexual offender/predator visit a park, school, or child care center?
There are restrictions for offenders convicted of certain crimes, please refer to Florida Statute 856.022 and 775.21(10)(b) for more information. Top
Can a sexual offender/predator petition the court to be removed from the registry?
A registered sexual offender meeting Florida statutory criteria is required to register for life, unless he/she has received a full pardon or received post-conviction relief for his/her qualifying offense.
Certain individuals required to register as sexual offenders that have been lawfully released from sanctions, confinement, or supervision for at least 25 years and have not been arrested for any felony or misdemeanor offense since release may petition the criminal division of the circuit court of the circuit where the conviction or adjudication occurred for the purpose of removing the requirement for registration as a sexual offender; provided the offense was not based on an adult conviction or violation of:
The court may grant or deny such relief.
There is no provision in Florida law allowing sexual predators to petition the court for removal of the sexual predator designation. Top
Are there consequences if a sexual offender/predator fails to comply with registration requirements?
Failure of a sexual offender/predator to register as required by law is a felony.
Note: If you have reason to believe a person has violated registration requirements please contact local law enforcement. Top
Is a sexual offender/predator allowed to have an account on a social networking site?
There is no Florida law that prohibits an offender from having a computer, using the Internet, having an email account, or obtaining an account on a social networking site based solely on his or her designation as a sexual offender or predator. However, if an offender/predator is currently under supervision, he or she may have specific guidelines/restrictions (which may include using a computer, accessing the Internet, or setting up an account with particular websites) set forth by a judge. This information can be obtained by contacting Department of Corrections or Department of Juvenile Justice directly.
If you believe that there is any illegal material presented on a website, please contact your local sheriff's office or police department, as well as the Florida Computer Crime Center (email@example.com) for issues such as potential child pornography or solicitation via the Internet. Top
Why does a deceased sexual offender/predator still appear on the website?
Sexual offenders/predators reported deceased remain on the website for one year after the date of death as provided on the death certificate. This allows victims, the community, and local law enforcement time to be notified. Top
How do I look up sexual offenders/predators in other states?
FDLE currently has links to The National Sex Offender Public Website and other state sex offender registry websites at http://offender.fdle.state.fl.us/offender/Registries.jsp. Top


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Research for the ages
Undergrad students' projects are showcased
Editor's note: Joshua Blume is a senior at the Jon M. Huntsman School of Business who is majoring in international studies and economics.
The Utah Statesman
By Jessica Bedingfield
The first floor of the Merrill-Cazier Library has a new look this semester due to recently-hung pictures of the new USU undergraduate researchers.
. . .
Joshua Blume works on a project focusing on missionaries for the Church of Jesus Christ of Latter-day Saints.
"We compare how the Church runs as a business to other international companies," Blume said.
He served a mission for the Church in Minnesota.
"I am doing an analysis on the coming home process," Blume said. "We are trying to find out if there are ways to make it easier."
He encourages his fellow Aggies to meet with their professors.
"They really enhance your education. I have really liked all of my professors," he said.


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Hopefully, this news means some new FLGs will be coming. I've always wondered, for example, why ILF does almost nothing with Brazzers and Naughty America. Brazzers, in particular, is the most heavily-trafficked porn site in the world, and although there is a discount portal, ILF still have only one major (note major) "Brazzers girl" in their lineup--Lisa Ann. I've always wondered why we never got sleeves for Shyla Stylez, Ava Devine, Phoenix Marie, Diamond Foxxx (Full Disclosure: My favorite), Rachel Roxxx, Jayden Jaymes et al., and why ILF didn't mold some or all of them and then set up an online storefront for a Brazzers lineup that could be accessed from either party's site. Sure, there would be some revenue-sharing, but the amount of traffic that Brazzers, Naughty America and the other major labels like Elegant Angel, Evil Angel, Wicked, etc. would bring to ILF is surely nothing to sneeze at? And it's not like the major models that shoot for those sites don't have legions of Twitter followers to whom they could promote their Fleshlights, is it? The idea seems to sell itself: ILF sells product, the company gets to sell the idea of "fucking" their top stars to the fans.
And for their part, ILF could occasionally offer new textures and a choice of model to go with the texture.
But maybe I'm just dumb.
honestly am not bothered as long as this means new FL girls
to be honest I think it is a good idea to keep it one texture for each orifice because it takes far too long to decide otherwise
To all those people complaining...
Eh, if it made sense I would understand. I'm just not a fan of being pressured to buy something. I put off my bi-hive order a while ago and I don't like thinking I have to get it now or it will be gone. They tricked buyers with the mini-lotus, stuff like that also affects my mindset when deciding on a purchase.
I feel that once they have changed them all to lotus they will bring out many new FL girls regularly to keep fans happy. To be honest I would much rather buy new girls than new textures. I thought the main part of the excitment of owning a FL was being able to fuck your favourite pornstar
I dont know, I'm not buying a texture again for the girl. There might be like 2 or 3 pornstars (that are not even FLGs yet) that could make me reconsider this, but I doubt I would do it.
Also, I thought the FLG's cost 10 more than regular sleeves. Keeping the signature textures there = more money? I don't remember.
I appreciate the heads up on this. A little more info on what's coming up would be nice.
I doubt the textures are going anywhere, it would be ridiculous to take all those amazing textures they've developed (including those more recently released) which have great reviews and a following and just throw them away.
I'm hoping they'll be moved to the cheaper standard line with non-pornstar orifices that don't have any expensive contracts attached to them. I'm also hoping they keep them sleeve only.
This would make the most sense as they'd be able to keep their prices down (one of the main complaints about fleshlights compared to their competitors) and still offer an amazing selection of sensations.
I do wonder though how the FLG/FJB lines will fair though without their signature textures. Me personally, I already have the lotus and forbidden and as much as I like the lotus I doubt I would buy another one unless it was rather cheap. I don't really care what slightly different orifices it has on it (unless it's something really out there like the alien), I mainly care how great it feels.
Last edited by Rayne; 03-30-2013 at 02:52 PM.
For me personally, I bought the fleshlight girls so that I could jack with her while watching a porn movie with her in it. This was all the fun for me as I was literally seeing and feeling her vaginal lips wrapped around my penis as her lips were being spread by a male porn star on the screen. It also gave me incentive to buy as many movies with the fleshgirl as the star in these movies. I'd rather have the signature line with different textures inside. I rather enjoyed the different feelings provided by those different textures. I also enjoyed collecting all the different girls with their different textures. What motivation would I have just to buy the girls with all the same standard lotus texture, even if they were my favorite porn stars? I also wouldn't mind spending the extra $10 for the fleshlight girl verses the standard fleshlight vaginal outer mold. There is a big difference in the feel of the flesh of the girl's mold verses the original flesh used for the original, stu, etc. I just don't understand this move unless they plan to reintroduce new girls into the line-up, which I doubt they will do as it just wouldn't seem logical with the move of getting rid of the signature lineup.
I feel like they only say that to push the sales!
But if they really take them out forever, tuey are f*****g stupid!
I don't get why companies take out super successfull products for new stuff, that isn't safe to be successful as the former ones.
When you really think they are then just release them too.
2 very successful things for sale. What you want more?
Or the big boss got way too hungry for more money, got long pockets and short arms and doesn't want to pay for the girls contracts anymore.
So he wants a product which brings money like the FLG line without any extra expenses like the girls contracts!
Last edited by SativaRoseLover; 03-30-2013 at 03:14 PM.
What they are doing is very risky in this economic environment. Sometimes it is best to leave what works and slowly introduce the new. Whenever you introduce something new, it will be a risky move all-around. Unless they plan to make something unusual or very popular in a slightly lower price, I just don't see how they will make as much money.
It's their risk, so I don't care.
I'll see what the replacement for the FLGs which I loved and which got me to FL is like and if it's bullshit........they lost a customer!
Honestly NOTHING of the recently released stuff was really good imo, so why should the FLG replacement will be as good or better as FLG is or was?
I really doubt it!
Last edited by SativaRoseLover; 03-30-2013 at 03:48 PM.
As it turns out, when the announcement came out I already had every single signature texture of the current FLG lineup, plus a Jenna Haze Forbidden and Asa Akira Swallow. So I have all the FLG textures and this weird ILF move doesn't affect me personally. Maybe it's time for me to stop being such a collector. If ILF comes out with more interesting products I'll be interested, but otherwise I have more than enough to keep me happy for a long time to come.
But did I get that right guys?
They "ONLY" stop selling the signatures and the normal (Lotus + Swallow) will still be on sale?
If so, they maybe create some very new textures which are available with every of the girls to save production costs.
I guess I'll weigh in on the announcement. I dont think the textures are going anywhere, that would kill sales. I dont think its because the pornstar's contracts are too expensive. What I think is going on, and this is only speculation, ILF has decided to no longer associate exclusive textures with specific porn stars. This gives them much more flexibility and the ability to add many more girls to the lineup without developing a new texture for each girl. Lotus, Swallow, and Forbidden will be the standard textures for each girl molded, but they may now offer a build your own for the fleshlight girls and add many more stars to choose from. Which you would be able to choose from the exclusive textures we all love. I'm actually excited about this if I'm right cause we could get some really nice molds of stars soon.
I hope so. There's a few textures I would definitely go for if they were available with other orifices. Some of the girl orifices don't appeal nearly as much as others, while having quite nice looking textures. So IF this is the direction they're going, I welcome it. But I shall just wait and see what is going on.
I know that I've read lots of complaints about the Lotus texture. I like it, but honestly I did find that it does get kind of boring after a while. The only two signature sleeves I bought were the love humps and lotus garden, and I like both of them.
Now I honestly imagine that a "build your own" option would be cost prohibitive for all the combinations they offer in terms of setting up the molds and stuff. You don't know how many you need, how many you can sell, etc.
However I'd like to offer another suggestion, if possible: Start mixing up the textures and periodically change what special textures are offered. Basically, start offering the old "signature" textures with other FLGs for a few months at a time. It would be a way to keep some variety in the lineup, but if the special textures were limited to two, three, or even four FLGs at a time, it might help with the problem that I'm sure fleshlight is experiencing at this time: they probably have too many possible combinations to easily handle it.
Right now there isn't anything that interests me, but if the mini-forbidden were to be brought back, or if some of the signature textures were offered for different FLGs, or even, as odd as this might sound, if some of the original textures were offered with an FLG, I might just be convinced to buy.
I cant really imagine that there isnt a way to come up with a flexible way to combine molds with textures. like having the master (negative) stencils seperate to be able to combine whatever is needed.
This way I imagine it would even be possible to have various inner texture pieces stacked into one another so make custom textures..
Then again, I'm not an engineer. Maybe I should become one
Made a crappy drawing.. cant imagine something like that isnt doable at all... and I'm not even talking about the custom thing, since there are more than enough textures that I would buy before considering a custom one.
Last edited by zam; 04-01-2013 at 02:04 PM.
Hmm, guess this means I need to finally decide between Love Humps or Vortex before they're gone...
I was leaning towards Love Humps because I'm looking for a lower intensity sleeve for long FLights. My Wonder Wave is great for quickies but very hard to use for longer than 30 minutes. If there's a better insert for very long edging sessions and staying wet, I'd get that or maybe both.
I have the Love Humps and like it a lot for low intensity. It also holds lube well because of the depth between the humps.
I want to get a Vortex too.
A) ILF needs to manufacture every girl/texture variants... far more variants than the old FLG signature texture approach.
B) Manufacture sleeves for each customer order = higher price and longer order fulfilment time.
Either case, ILF needs to have moulds for every girl/texture variant they decide to offer, which sounds expensive.
I'll address B first. While it would be nice if they would offer every possible combination, and I would certainly purchase a few custom sleeves, I know that the costs associated would be far too great to be practical at current prices, and if prices were raised to make it worth wile, I imagine the product would be too expensive to sell.
The only way this might work is, assuming that at least one part of the mold was very easy to change in just a few seconds, for example the orifice, would be to wait until they had a large enough order for a certain texture and then crank out the variations in mass. Failing that, lets say that Fleshlight calculated that they needed to make and sell 3,540 sleeves to make it worthwhile. Then the answer would be to simply wait until 3,540 people ordered a custom combination and then do a run.
As for A, yes, far more possible variants than before, but not necessarily far more actual variants. For example, if they decided to offer only three FLGs with one each special texture for a three or four month period, it would be a much smaller number of actual combinations.
I hope its time to introduce realistic internal orifice!!
Even though I have only had my Alien Fleshlight for about a month, I went ahead and ordered a Misty Stone Bump and Grind. That was one of the ones I was thinking about getting for my next sleeve and decided that I better get one. I ordered it on amazon since I have an account there already and it states that it ships directly from ILF so I know that it will be a genuine FL. I also ordered a 32oz. bottle of Gun Oil H2O lube because of the reviews I have seen about it on this site. It should be here in about a week so I am already eagerly awaiting the new addition to my FL collection.
what two Girls that are being discounted are a must have i already have Stoya. I was thinking the speed bump, but the instructor looks good and easy to travel with. i am looking for a tight and intense sleeve and a relaxed sleeve for a lazy afternoon wank session. thanks.
The Mary Queen (Miela) Mini-Lotus is highly recommended for a tight and fairly intense sleeve that is also realistic. The Primal from the Fleshlight girls Euro line is also highly intense and tight. But if the Stoya you mention having is the Stoya Destroya most people say it is so similar to Primal that it isn't worth getting.
I really like the Teagan Love Humps for low intensity. It's still above average tightness or so.
I was thinking about the riley steel nipple alley is what i meant
I was actually bored and decided to check up few internet sex shops of what they have in stock cause it got me curious
it was rly no suprise that there was only basic stuff, fleshlight alien? - tough luck bro...; FLGirls series? - yes!, plenty, all with lotus texture!; FL Flight? - uhm, maybe you should ask at Lufthansa...
it is like "hey, do you have fleshlight of model BiBi Jones with bi-hive textures?", "no, sorry! but we have over 9000 of this amazing fleshlight pink lady original toys in our stock for just 49.99, you wont regret!"
so yea... it might be hard to believe that for 'forum minority' but imo just blame wholesale buyers who prefer to buy and sell just the very basic stuff cause its hard to explain to random pleb that destroya texture wont cut his 4' dick in half
its like supermarkets, you can find only mainstream stuff, generally basic textures, STU, sometimes ICE and mainstream hardcore porn stars (Jenna Haze? sure, Piper Fawn? lol, who would buy a readhead who doesnt have 50 anal videos on her account... /sigh), all with lotus texture because only outside and how well you present/advertise product is important and not whats inside and rly matters
dunno, i had a cynical smile when i was searching but now it made me annoyed as im finishing writing... tough luck bro (srsly i hate this sentence)
I'd love to have a fleshlight of her muffin.
now i want a muffin
Wow, I just saw the email and had to log in to see what was going on. Crazy. I have a girlfriend right now so I haven't really needed to break out the fleshlights in a long time, but my Twista was getting worn. I was thinking of getting a new one for a while. I don't know whether to jump on it or just forget it. The Twista texture just felt so good, it blows my mind that it's going away.
Any chance the signature textures will be replaced by something else? Y are they doing this, i would have thought they sold better than the lotus and this is a stupid move.
So matter what ILF have planned to replace the signature textures, I have a very hard time imagining anything but less texture and orifice choices :P
I would welcome a new case design though as long as it's compatible with the old sleeves.
I wonder what the company will do. Sure it's a financial boost now but what will they do once their stock runs out? I don't think they are quitting, otherwise they would have told us and people would hoard all remaining fleshlights (you know who you are hoarders ). I don't think this product makes a loss, they are cheap to produce and it's got great branding cause when people see a male masturbator they compare it with the fleshlight and most people looking into this stuff know the name fleshlight. And this is somewhat of bad PR that they will stop the line-up of signatures without telling future plans. Fleshlight producs are like drugs, once you had one you need more. No I think they are changing things up to the Apple business model (only a few good selling quality products). Just a few inserts which sell good without the porn name attached to it. why would they pay a person money if they don't have to right? Because let's face it people buy the variety of different inserts and not the outside. a nice looking vagina is fine with me and I don't care if it's modeled after Jesse Jane or Stoya. My penis has no eyes and I'm not watching the fleshlight I'm probably watching my gf using it on me or some kind of adult material. It could also be the case that they want to end the contracts with the current stars and make more money on new ones such as Christy Mack or Jessica Robbins. Maybe they will reduce the fleshlight range and produce more for the Flight. As they already brought more variety with the white ones. Also why not SIAC's without alcohol but hidden as an energy drink or something.
Edit: so the company saysNote: Once our stock is depleted, the Fleshlight Girls line of products will still be available, but only in the Lotus, Swallow, and Forbidden textures.
So I guess they are going the Apple route and only keep the best sellers in order to keep it simple. Although I find it strange as many of you buy most textures and even doubles.
Last edited by bbaasje; 04-05-2013 at 09:49 AM.


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Despite spending a week in the nation's capital, shaking President Barack Obama's hand and being accepted into Harvard University, Michael Kikukawa's life is "still pretty normal," he said.
"My life is dominated by school," he said. "I don't have to apply to any more colleges, which is nice."
In December, Kikukawa became the first Molokai High School student in the school's 84-year history to be accepted into Harvard. And last month, the senior was selected as a delegate to the 51st annual United States Senate Youth Program in Washington, D.C.
Article Photos
"It was probably the best week of my life," he said about his trip to the capital.
Kikukawa and Keagan Sakai-Kawada of Hilo were among 104 student delegates - two chosen from each state - at the program and had the opportunity to study the federal government.
They also met with government officials, including President Obama.
"I shook his hand. He was really nice," said Kikukawa, who was placed directly in front of the president during his speech to the student delegates at the White House. "He chuckled when I told him I was from Molokai . . . He said, 'What's up with the Oahu kids?' "
The high school senior visited the Jefferson and Lincoln memorials, along with a special dinner in the Rotunda of the National Archives Building that displays the Constitution, the Bill of Rights and the Declaration of Independence.
"It was pretty amazing," he said.
Although these experiences have become the new normal for Kikukawa, who was born and raised in Kaunakakai, it is a life he expected.
In his sophomore year, he began inquiring about Ivy League schools, including Harvard.
"He came to me and said he wanted to apply to Harvard," said Earl Nakamura, a retired teacher and vice principal with the school. Nakamura still has an office at the school and counsels younger students about college.
"I contacted the school and showed him the email they sent back and said this is exactly what you need to do," he said.
Kikukawa piled on advanced placement classes and got involved with a number of student organizations. He was a volunteer in Mufi Hannemann's congressional campaign, worked in the Governor's Office and took classes at Iolani School on Oahu.
"I've had lots of bright kids through the years, but Michael always takes it a step further," said Nancy Lawrence, who taught Kikukawa honors English in 9th and 10th grade, as well as AP literature in 11th. "He doesn't just go for the grade," she said. "He's really interested and intellectually curious."
Currently, he is the student government president, Hawaii State Student Council vice chairman and holds about a half-dozen more positions in state and schoolwide organizations.
"His resume is two pages long," Nakamura said. The counselor said Kikukawa's success is influencing younger high school students.
"You got 8th- and 9th-graders looking at Stanford and Ivy League schools," he said. "So I tell them this is the time to apply and start working."
However, even with his laundry list of accomplishments and accolades, Kikukawa is still surprised and nervous about attending the prestigious school.
"When I'm given the opportunity, I think 'Wow, I'm gonna be going there in less than a year,' " he said. "It amazes me. I'm really nervous about, not necessarily competing against other students, but handling that level of academic rigor and still have a life."
The senior graduating in May said he's nervous about how to pay for the university's $52,652 tuition and room-and-board fees.
Kikukawa has accrued about $15,000 in scholarship money and is constantly checking the mail for scholarships and financial aid.
With his future set for Harvard and a career possibly in law or political science, Kikukawa said people expect him to be "something grand like the next governor of Hawaii."
But Kikukawa said people told him he could open an ice cream shop and they'd still be proud of him.
"That meant a lot because it made me realize that the community will always support me," he said.
* Chris Sugidono can be reached at email@example.com.


text:
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Prince Harry Practices Being an Uncle While Visiting Colorado
In town to kick off the Warrior Games in Colorado Springs, where more than 200 wounded servicemen and women from the U.S. and Britain will participate in sporting events, the young royal, 28, cooed and played with 10-month-old Sebastian Wilkowski, who was cradled by his mom, Julia, at a pre-Games brunch.
Dressed in army fatigues, Harry was meeting old friends, donors and supporters of the Games when the little fan caught his eye.
Julia, 37, says, "[Harry] said, 'It's great to meet you and asked, 'Who is this little guy?' And, 'You have a lot of hair for a 10-month-old.' He came closer and did a little small talk with the baby, and he just reached out and then made a little raspberry and funny faces. He made silly faces, and then he started blushing a little bit because he didn't think Sebastian would grab him," she adds. "Then Harry went to walk away and came back with another funny face. It was cute."
Courtesy of Kip Wilkowski
Her husband Kip, 43, a retired air force F16 pilot, says, "He is wonderful with children."
"I think he'll make a great uncle. He was holding his hand – all the things you do with babies," Julia added.
Harry, who has served in Afghanistan and visited wounded soldiers and recovering servicemen in Washington, D.C., has said the Games are a central part of his week-long tour through several states.
Speaking at the brunch, Harry said he hoped to "continue to enlarge this fantastic cause."
"I don't see why it wouldn't be possible to fill a stadium with 80,000 people not to watch the Olympics, not to watch the paralympics but to watch wounded servicemen fight it out with each other – not on the battlefield but in a stadium."
Moments earlier, Harry, often ad-libbing as he spoke from notes and putting his hand on his heart, had talked about the changes in the year since he was last at a Warrior Games event.
He had since served in Afghanistan with U.S. comrades-in-arms and knows all about "what he called tragic consequences: life-changing wounds and the death of friends."
Held for the fourth consecutive year at the Headquarters and National Training Center of the U.S. Olympic Team, the Warrior Games includes teams from the U.S. Army, the United States Marine Corps, the U.S. Navy and Coastguard, the Air Force and the Special Operations Command.


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ASM Undergraduate Research Capstone Program (UR-Capstone 2016)
FOCUS on ASM Fellows Fellowship Report: (2011 - 2013)
ASM UR-Capstone Testimonials
The ASM Undergraduate Research Capstone Program (UR-Capstone) is the successor program to the ASM-Microbiology Undergraduate Research Fellowship Program, formerly the Minority Undergraduate Research Fellowship program from several years ago.
The goal of this program is to "fulfill the later stages of undergraduate professional development" for underrepresented minority students (URM). This program seeks to enhance the presentation skills of students after their research experiences. The ASM Undergraduate Research Capstone Program (UR-Capstone) will focus on enhancing presentations and networking skills, and provide students with resources to transition to disciplinary scientific meetings.
Prospective applicants must have conducted research in microbiology prior to applying to the UR-Capstone.
Application Process
Prospective applicants must:
- Have participated in an undergraduate research program at a U.S. based institution
- Submit a research abstract for presentation to ASM Microbe 2016
Note: For more details on abstract submissions to ASM Microbe 2016, please visit: http://gm.asm.org/index.php/abstract-submission/submit-your-abstract.
Selected students will:
- Present the research at a national meeting
- Attend the Research Capstone Institute before ASM Microbe 2016, to enhance their chances of furthering their graduate/professional training
Preference will be given to juniors and seniors.
Applicants must:
- Be an ASM member,
- Be U.S. citizen or Permanent U.S. resident,
- Be enrolled as full-time matriculating undergraduate student during the 2015-2016 academic years or in a post-baccalaureate program. (Freshmen with college level research experience, sophomores, juniors, or seniors who will not graduate before December 2015),
- Be from an underrepresented minority group (groups include African-Americans, Hispanics, Native Americans, Alaskan Natives, and Pacific Islanders), a community college, a minority serving institution, a first generation college student or non-traditional student,
- Have conducted research in the microbiological sciences at a U.S institution (host mentor is not required to be an ASM member, but recommended),
- Have a strong interest in obtaining a research career and post-graduate training in research within the microbiological sciences, and
- Be accepted to present a poster or oral presentation at ASM Microbe
Note: Students cannot be a previous recipient of a UR-Capstone award
The UR-Capstone program is supported by funds provided by the American Society for Microbiology (ASM).
The awards package includes:
- Up to $1500 travel support will be provided for students who will attend the ASM Research Capstone Institute and present the results of their research project at ASM Microbe 2016. Travel support will cover airfare, hotel accommodations, and the ASM Microbe Meeting registration
- Travel funds are contingent upon acceptance of an abstract for ASM Microbe 2016
Criteria for Selection
Student applicants should be able to demonstrate:
- Academic achievement
- Achievement with previous research experiences or independent projects
- Commitment to research
- Career goals as a research scientist
- Personal motivation to participate in the program
- Leadership skills
- Involvement in activities that serve the needs of underrepresented groups.
The application deadline has passed.
For more information, contact:
ASM Undergraduate Research Capstone Program (UR-Capstone)
Education Board
American Society for Microbiology
1752 N Street, NW
Washington, DC 20036
Tel: 202-942-9283/Fax: 202-942-9329


text:
Billboard publishes its first music chart, Sputnik falls to Earth, The Beatles record together for the last time, and Nancy Pelosi becomes the first female speaker of the House, all on this day.
On this day: January 4UPDATED 1:00 AM CST Jan 04, 2016
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A technique for maintaining large amounts of speed in half-life by repeatedly crouching very quickly. It's very difficult to execute without a script. Also refered to as "chopping."
That medic chops so fast!
von b0b 23. Oktober 2003
Trending Now
Can you define these popular missing words?
Top Definition
A 180-ollie on a surfboard. A common maneuver that has been played out recently at a professional level. Can also be performed while windsurfing
Quit braggin about your chop-hops bro, they've got no style.
von Joe Wonder 12. Oktober 2006


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It's Just a Router Issue!Thursday, January 6th, 2011
Some of you may be aware that my background is actually in computer programming. These days I use those skills for Shizzle Dizzle Magic, but I don't offer them professionally.
That has not stopped friends and family from believing that I'm their built-in 24 hour free of charge tech support line.
Believe me, some of these people are unbelieveable. I barely get one issue resolved before they are HARD AT WORK screwing something else up!


text:
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Charisma Magazine
Page 9 of 30
World Relief Reaching Young Afghan Refugees
Ross Maracle Works to Heal Canada's Native People
Intimidation Hasn't Stopped Egyptian Christians
Waterproof Breaks New Ground for Christian Films
COGIC Leader Orders Merchants Out of Church Convention
Brownsville Assembly of God Moves Forward After Split
Roberts Liardon Steps Down
Barnett to Pastor Historic L.A. Church
Prophetic Word: The Angels God Has Sent to Fulfill Your Prophecy
"God wants me to encourage you that your breakthrough is imminent."
When the Holy Spirit Foils the Enemy's Destructive Plans
It wasn't a still small voice giving me an instruction. It was just an impression in my ...
6 Warning Signs of Spiritual Danger
There are clear signs when a ministry has veered away from truth and into deception.
Early Warning Signs He Isn't God's Man for You
Asking these questions is vital if you want a Christ-centered marriage one day.
5 Truths to Understand When Leading Leaders
If you are in leadership for any length of time, there will probably come a time where you will need to lead other leaders.
7 Reasons Your Organization Suffers from Marketing Malpractice
Receive Dr. Steve Greene's 7 Reasons Your Organization Suffers from Marketing Malpractice, plus 3 Things to Do Now to Prevent Further Damage as your FREE download.
Prophecy: 'We Are in a Season of Supernatural Restoration'
"God is so big that even if He has to add extra years onto your life, He can do that."
Try This Prayer Position for 30 Days—You May Be Surprised at the Results
For one woman, it's revamping her passion for intercession.
When Believers Crucify Each Other in the Name of Discernment
There's a difference between a prophetic spirit and a critical spirit.
Identifying the Root Issue Behind Many Addictions
When this need isn't met, it opens the door wide for all kinds of satanic deception.
Respected Assemblies of God Leader's Essential Secret to Success
During Dr. Charles Kelly's tenure as a superintendent in North Carolina, his district ...
Katherine Ruonala: Operating in Creative Miracles
The prophetess explains how God has equipped her for supernatural healing—and how you can ...
New Christian Film Leaves Pro-Choice Audience in Awe
The producers of Voiceless are hoping their critically acclaimed movie can help change the ...
5 Truths to Understand When Leading Leaders
If you are in leadership for any length of time, there will probably come a time where you will need to lead other leaders.
Truths to Restore Your Soul After Excruciating Rejection
This lesson from Deuteronomy 15 holds the key to your emotional and spiritual healing.
These Weapons Are Sure to Send the Enemy Into Retreat
Prophetic voice Jane Hamon dares you to arm yourself with these and be a warrior for the kingdom.
Resist Satan's Strategy to Lure You Into This Death Trap
Beware of these early warning signs of the devil's deception.
If You Expect to Lead, You Must Embrace These Disciplines
Your ministry won't be effective without them.
What God Is Trying to Tell You When He's Silent
Jesus knew what was going on when His prayers were answered only with silence. It's something ...
Filling God's House With His Shekinah Glory Begins With These 3 Steps of Obedience
Solomon followed these steps, and God answered in an overwhelming way. We too can experience that ...
5 Common Pitfalls That Can Drain the Joy Out of Your Marriage
You've probably made some of these mistakes. Grow from them.
God's Power at Work in the Church Today
Charisma's founder, Steve Strang writes about today's hottest topics affecting the Christian faith.
What Billy Graham's Daughter Did to Save Her Marriage
If your marriage is facing rocky times, these principles can make a world of difference for you.
Continue Your Journey with the Holy Spirit
Follow God on the most fulfilling journey of your life with Encounter the Holy Spirit! Break away from past hurts and press into the One who wants a personal encounter with you.
Dream the Unimaginable In His Presence
Reach your full potential and be led by His Spirit. In His Presence takes you to a deeper understanding of who God is and how he communicates with us.


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Closed Captioned
This empowering class begins with essential lessons for new knitters: choosing supplies, casting on, knitting, purling and binding off. Learn how to increase, decrease, make a buttonhole, knit lace, block, seam and read patterns. Stefanie shares her "purls" of wisdom as she teaches you how to knit a scarf then ups the ante by demostrating a host of useful techniques that you can come back to again and again.
Instructor Stefanie Japel discusses the skills, topics and patterns that are covered in Knit Lab.
Learn about a wide variety of yarn, needles and several handy knitting gadgets.
This lesson introduces students to the long tail cast on method, knitting's most common method of casting on.
Learn the two main stitches used in knitting: the knit and purl.
Learn how to create purl ridges using the knit and purl stitches learned in Lesson 4.
Stefanie introduces lace with a simple combination of increases and decreases, which will help you make the Lacy Keyhole Scarf.
Learn how to use increases and decreases to create keyholes and buttonholes, and finish up the Lacy Keyhole Scarf!
Stefanie shows you how to weave in the ends of a finished project for both garter and stockinette stitches.
Learn how to wet block and steam block, as well as when to choose each method.
Learn how to use the basic knit and purl stitches to create more complex, detailed patterns, including the seed and basket-weave stitches.
Learn about several different increases that will help you shape your garments.
Learn the Slip, Slip, Knit decrease as Stefanie teaches you how to use decreases to shape your garments.
Stefanie introduces you to several additional casting on methods: cable cast-on, knitting-on method and backwards-loop method.
Learn how to use increases and decreases to shape socks, sweaters and shawls.
Demystify pattern reading. Learn how to read a basic pattern, including charts and common pattern abbreviations.
Turn materials like trash bags into fun knitting projects. Watch Stefanie knit a bath scrubber from tulle material.
"I loved this class! �I haven't touched knitting needles for over thirty years so before I took it I �was horrified that I would make a mistake. �I'm amazed at how far I have come. This class gave me the confidence to keep going with my knitting. �And the lovely key-hole scarf is a great way to start too.� Stephanie Japel is very funny and warm teacher and she makes you feel completely engaged in the lessons�this class is worth every penny you spend on it!"
- nmajkut
California, USA


text:
Top Definition
Achieving success with luck when failing the attemp (from the simpson series) "a fluke"
The star player in basketball game slipped during the last seconds of the game causing the ball to get accidently hurled at the net and making the winning shot and so "pulling a homer"
dari afshin-mrak Minggu, 13 Mei 2007
Trending Now
Can you define these popular missing words?
Doing something stupid, in reference to Homer Simpson
Oh dam i just pulled a Homer.
dari Gumba Sabtu, 18 Juni 2005


text:
Keynote and Overview of Windows Phone
- Posted: May 31, 2011 at 5:25AM
- 1 comment
Loading user information from Channel 9
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Loading user information from MSDN
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Loading Visual Studio Achievements
Something went wrong getting the Visual Studio Achievements
Right click "Save as…"
Windows Phone Mobile Day 26.5.
Keynote and Overview of Windows PhoneBrandon Watson, Microsoft
Oops, something didn't work.
well if 'Apollo' is based on NT kernel, and the application platform is unified with Windows 8 then Native Code will be supported, along with full CLR and Silverlight and HTML5 right ? right ???
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text:
Top Definition
A thumb thats exceedingly wide and short. Like a chode but its a thumb, hence chumb. See Megan Fox's thumbs for an example!!
A: OMG look at her thumb its so wide and short!! Who has thumbs like that??
B: Oh yeah she's got a chumb!!
B: Oh yeah she's got a chumb!!
dari Sickskier1 Minggu, 20 Februari 2011
Trending Now
Can you define these popular missing words?
a thumb that is short and fat, like a chode but with a thumb:)
dari Jon Queerbeck Kamis, 26 Januari 2012
a dumb chick, hence chumb
a chumb that lick cock!!!!
dari C_C Selasa, 07 Juni 2005


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As Immunotherapy Revolutionizes the Cancer Treatment...
Developers of DTC Genetic Testing Are...
Expanding Use of NGS Has Largely...
NSCLC is "Major Battlefield" as Merck,...
Scientists report on the discovery of a protein expression feedback mechanism that may explain why the BRAF inhibitor vemurafenib (PLX4032) is an effective therapy for melanomas carrying the BRAF V600E mutation but is much less effective against colon cancers carrying exactly the same mutation. A team led by scientists at The Netherlands Cancer Institute found that inhibiting BRAF in colon cancer actually triggers upregulation of the epidermal growth factor receptor (EGFR), which supports further tumor growth. Melanomas only express low levels of EGFR, so this feedback mechanism doesn't occur.
René Bernards, Ph.D., and colleagues subsequently showed that treating mice carrying colorectal cancer xenografts using a combination of vemurafenib and an EGFR inhibitor was much more effective at holding back cancer growth than vemurafenib alone. Reporting their studies in Nature, the team suggests their data provides "a strong rationale for a clinical trial combining BRAF and EGFR inhibitors in BRAF V600E mutant CRCs." Their paper is titled "Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR."
Activating mutations in the BRAF oncogene occur in about 70% of primary melanomas and about 10% of colorectal cancers. However, while 80% of BRAFV600E melanomas will respond to vemurafenib, the response rate among relevant colon cancers is only 5%. To investigate the molecular mechanism behind this inherent resistance of BRAF-mutated colon cancers to vemurafenib, the researchers applied an RNAi genetic screening approach to see whether knocking out specific kinases might restore this drug sensitivity. To this end they screened an shRNA library representing all 518 human kinases and another 17 kinase-related genes.
The resulting data strongly indicated that suppression of EGFR synergized with BRAF inhibition. This notion was supported by studies in WiDr human colon cancer cells. Effecting EGFR silencing using an shRNA had no effect on cell proliferation, a result tallying with clinical observations that KRAS or BRAF mutant CRC cells don't respond to EGFR-targeted mAbs, the authors note. In contrast, when EGFR-silenced WiDr cells were treated with vemurafenib, there was significant inhibition of proliferation.
Similar antiproliferative effects were observed in three different CRC cell lines treated with vemurafenib in combination with the anti-EGFR drugs cetuximab, gefitinib, and erlotinib. These findings are "consistent with the notion derived from the shRNA screen that EGFR inhibition is required to elicit a response to BRAF inhibition in CRC cells.".
As to why EGFR inhibition renders CRC cell lines susceptible to BRAF inhibition, further antibody-based studies on lysates of drug-treated cells showed that vemurafenib treatment leads to strong activation of EGFR via Tyr 1068 phosphorylation. This feedback loop could be blocked by co-treatment of cells with vemurafenib and either cetuximab or gefitinib. Moreover, vemurafenib treatment inhibited MEK and ERK activation downstream of BRAF but activated AKT, which operates downstream of EGFR in a pathway parallel to BRAF, they note.
Significantly, treating CRC cell lines using the MEK inhibitor AZD6244 had the same EGFR-activating effects as vemurafenib therapy, in terms of EGFR phosphorylation, whereas administering both the MEK inhibitor and an anti-EGFR inhibitor blocked cell growth.
EGFR is expressed primarily in epithelial cancers, whereas melanomas are derived from the neural crest, providing an additional clue as to why melanoma responds better to vemurafenib than CRC. Indeed, when the investigators compared EGFR expression in a panel of BRAF(V600E) mutant melanoma, colon cancer and thyroid cancer cells, they found the melanoma cell lines expressed low levels of EGFR, whereas eight of 10 CRC cell lines examined expressed much higher levels of EGFR.
The two CRC lines that expressed only low levels of EGFR were subsequently found to be almost as sensitive to vemurafenib as the melanoma cell lines both in short-term and long-term assays. And, as expected, the thyroid cancer cell lines that also expressed high levels of EGFR were similarly sensitive to a combination of gefitinib and vemurafenib but not to vemurafenib monotherapy. In a final set of in vitro assays, the researchers demonstrated that ectopic expression of EGFR by normally vemurafenib-sensitive melanoma cells was enough to make them resistant to the drug.
The next step was to carry out in vivo evaluation. Immunodeficient mice carrying human WiDr and VACO432 CRC tumor xenografts were treated using either an EGFR inhibitor (cetuximab or erlotinib) or the BRAF-inhibitor PLX4720 (which is similar to vemurafenib but easier to formulate for use in mice) or a combination of EGFR inhibitor plus PLX4720. The effects in vivo mirrored those observed in the cell-based assays, in that animals given combination therapy demonstrated significant tumor growth inhibition, while those treated using either the EGFR inhibitor or PLX4720 derived very little benefit.
The Netherlands Cancer Institute researchers say human clinical trials evaluating combined EGFR and BRAF inhibition in CRC patients are warranted. They also point out EGFR expression levels may represent a clinically useful biomarker to help predict tumor response to vemurafenib monotherapy in BRAF mutant CRC tumors and aid in the selection of EGFR combination therapy in other cancers with the BRAF V600E mutation.
The frequent development of resistance to single targeted anticancer agents has led to a trend toward combining drugs in clinical trials, the team adds. "Our results highlight the power of 'synthetic lethality' genetic screens to identify which combinations of pathway inhibition are particularly effective. As such, these screens may help prioritize which combination therapies have the highest likelihood of being successful in the clinic."
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5 Mistakes Made by Every New Parent
There will never be anything in your life as frightening and demanding as becoming a parent. If you haven't had a child yet, every mom and dad reading this article will back me up when I say "You are not prepared" in my creepy Diablo III voice.
That is, until you have children beyond the first one. In that case, all of us look back on our first attempts at raising a child and laugh until we pass out from lack of oxygen. Virtually all of us go through it; it's nothing to be ashamed of. But eventually, we look back and realize that we all made the same common mistakes, like ...
#5. Not Giving the Kid Enough Space
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The First Child
In the early stages of parenthood, this is mostly associated with the debate on whether you should let them "cry it out." Look, I'll be perfectly honest here ... I don't give a crap how long you let your baby cry, as long as I'm not in the house while it's going on. A baby's cry is nature's car alarm, designed specifically to alert a parent that there is something that needs to be taken care of. "I'm hungry" or "I just shit my pants" or "Hey, a bear is attacking me." It's a primal alert system that has worked for millions of years, long before diaper rash creams and teething gel ever existed. I've never known a criminal whose actions could be traced back to the amount of time he or she was left crying in the crib -- that's for you, your doctor, and your instincts to work out. But ...
"Space" takes on a whole different, extremely important meaning when they're old enough to grasp the idea of entertainment. The problem with new parents (myself included) is that they want to spend every waking second with their child, participating in their games, playing pretend with them, and monitoring their every action to make sure they're not doing something stupid like eating a knife. And that's fine to a certain degree. But if you let it go on long enough without giving them some space, they will learn very quickly that the only way they can have fun is if you are involved.
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"I dunno, let's just get drunk or something. This sucks."
But After That, You Realize ...
That is an absolute disaster for an adult because it is physically impossible for us to put the rest of our lives on hold in order to make sure our child never experiences simple boredom. Learning that Mom and Dad aren't going to be there with them every second of the day is one of the most important lessons they can learn right out of the gates. Giving them alone time, even when their restlessness has turned them into whiny pieces of shit, will trigger their creative side, because now they have to find something to do without an adult showing them how. This is how all artists and hobbies are born. And some government agencies.
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"Goddammit, leave me alone. Would you just go find something to do? Wait, why are you crying?"
When they're older, it gets scarier. For instance, I have never had a problem with my kids having their friends over for the weekend, but for the longest time, I wouldn't let them stay at someone else's house. It was my overprotective side kicking in, and I didn't realize that it was sending a very clear message to both my kids and their friends' parents that said, "I don't trust you to not die when I'm not around."
It's so hard to remember that your core job as a parent is training them to survive on their own, and in order to do that, you absolutely have to start giving that leash some slack. No, it doesn't mean that you have to let a 7-year-old run all over town without an adult, but it does mean that if you need a break, you damn well deserve to take it, and your kid isn't going to be traumatized into a murderous rampage by it. In fact, they'll benefit from it.
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"No, you go ahead and take your break. I'll be waiting right here. Waiting ... and plotting."
If you're not careful with this, you could very easily end up ...
#4. Letting the Child Affect Your Marriage (and Vice Versa)
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The First Child
I can't even begin to tell you how many marriages I've seen break down into petty bickering and ugly bile because the new parents went to the extreme of devoting 100 percent of their attention to the child. In every case, one of the parents ends up feeling resentment for the other because of that void, while the other feels resentment in return because the first person appears needy and just keeps getting in the way.
And no, it's not just a case of "My genitals need to be slapped around." It's about inclusion and acknowledgement.
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"Why don't you tell that fuckhead behind you to stop being such a sulky pussy?"
But After That, You Realize ...
Yes, the child deserves to have two happy parents working in conjunction in order to make her life more comfortable and stress-free ... but equally as important is that you also deserve that same benefit. And that means taking some time for you and your partner. Unfortunately, that lack of connection is extremely common, because no new parent is comfortable leaving their kid alone with a babysitter for the first time. We feel like any time away from the baby makes us neglectful, and all we can picture when we're away is the sitter laughing maniacally while she flame-throwers our house and punts our child around the room like a soccer ball.
That line of thinking is horseshit. In order to make this work, you absolutely have to remember that romance is an actual part of your relationship. It's hard. When you have a child, your entire life turns into work and chores. Everything feels clinical because you feel like the slightest misstep could spell disaster. So what happens is that you end up neglecting things like dates -- or, hell, even an hour's break to just get out and call attention to the fact that you are emotionally committed to this person and that they are just as important as the child.
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"Yeah? Well, I love you, too, you stupid whore!"
Ignoring that is an excellent way to start a pattern of resentment and anger, and that's when the fighting begins. You cannot let that happen in front of the child, no matter what their age. I found this out firsthand back when I used to let my temper run rampant and unchecked. No, young children can't understand what you're saying, but they can sure as hell understand the tone and volume of your voice. And the last thing you want as a parent is for your children to learn from an early age that you are to be feared, because that destroys the bond of trust. Instead of opening themselves up to you, they learn to keep a safe distance, holding back anything that they think might trigger your crazy voice. "My dad is a fucking psychopath" is not an acceptable first impression.
Of course, when you have your second child, you look back on that and think, "No shit. I'm taking every opportunity to get out of this house and take a break. Otherwise, I'm going to pull my hair out. Hey, Fuck Partner, take me out to eat and then rub your floppy parts on me."
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"Tonight, it's just you and me. Don't even think about our fun-ruining piece of shit son."
#3. Comparing Your Kids to Other People's
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The First Child
My first son had what Thomas Sowell called Einstein syndrome, meaning that his speech developed very late, even though his math and science skills were far above average for his age. Of course, at the time, I didn't know that was even a thing, so we were really afraid he had a mental disability. Mostly because we had the bad habit of comparing him to our friends' children, who all seemed to be prodigies of language.
He was also a klutz. He loved playing under the dining room table, and no matter how many times he stood up and slammed his head into the underside, he never learned the lesson of "head plus wood equals pain." We just assumed he was an idiot.
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Look at that dumbass. He doesn't even know he's there.
But After That, You Realize ...
Kids are individuals, and they develop mentally and physically at different rates. It's a fact of life that seems like such common sense when you don't have children, but when you become a parent, it just flies right out the window. We want our kids to be "normal," but we forget what a loose term that is. Here, let me show you an example:
Can your 8-year-old play a guitar like that? Don't worry, it doesn't mean he's not talented if he can't. And by comparison, it doesn't mean that he's a genius if his math scores are in the top 10 percent of his school. So shut up about how fucking smart your kid is. Different minds, different circumstances. It's why so many talented high school athletes end up disappointed that they weren't good enough to make it to a college team, let alone play professionally. Or why 16 percent of teenagers will be coldly obliterated when they don't achieve their 1-in-30-million shot of becoming famous. They see other "undeserving" people making a living on TV, and they think, "I'm definitely better than that. This will be easy." They're only half right, but the half that isn't will feel like someone just walked up and ripped their ego's dick clean off.
It's just as dangerous for the parents, though, because it creates unrealistic expectations of their meat-spawn. By comparing them to other kids, they're setting the bar either way too high or way too low, instead of adjusting that bar to the child's abilities. And when the little bastards don't live up to those false expectations, the parents think there is something wrong with them ("them" could mean either the children or the parents). This is especially dangerous in a house with multiple children because it can trigger sibling rivalries, and then everything just goes to shit.
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"Oh my God, she filled it with broken glass!"
It's something you have to recognize with a sense of urgency: Nope, they're not the same as other kids. Just like you're not the same as any other human you know. They, just like you, are going to excel in areas where others don't. And sometimes, other kids will have abilities and traits that make your kid look like a philandering moron. And if your child has reached the age where he understands basic conversation, he is going to take your comparisons as "You're not good enough."
But, seriously, if your kids can't play guitar like that, they are pieces of shit and deserve to be abandoned.