text:
Piaget reduces its environmental impact
We have decided to take action to reduce our impact on the environment by ensuring that we use raw materials that have been extracted and processed according to the highest standards and by implementing strong corporate ethics. Piaget's excellence and prestige are not affected by our level of proactivity; on the contrary, Piaget's image and our pride in being part of it are strengthened.
Recycling obsolete sales and communication materials
Instead of incinerating its thirty-one tons of obsolete materials, Piaget decided to recycle them. In the end, it was possible to recycle nearly 20 tons of waste out of a total of 31.3, thus reducing atmospheric pollution and CO2 emissions by 19 tons.
Compensation for CO2 Emissions
Each year, Piaget pays an amount based on the balance of its total annual CO2 emissions to the Climate Care program. These funds are then allocated to projects aiming to protect the environment and help reach the Millennium Development Goals (MDG): energy efficiency, renewable energy sources, improved furnaces and drinking water procurement.
2012: The compensation of CO2 emissions was allotted to South Pole Carbon.
2011: A selection of projects of the Climate Care program received funding from Piaget.
Water and Solar Panels
An array of solar panels has been installed on the roof of our factory in Plan-les-Ouates / Geneva. Our goal is to use green energy to heat the water used in the restrooms on the Geneva site. The energy accumulated by the solar panels heats water to 60° Celsius. An effort to reduce water consumption was put in place at the Piaget headquarters. Only rain water and process water are used for watering gardens.
Approximately 97% of the electricity used at both Piaget Manufactures comes from a hydroelectric source. Piaget uses only FSC-certified paper for printed documents.
Environmental Policy
Our search for excellence through expertise of luxury goods goes hand in hand with respect for the highest ethical and environmental requirements. Piaget is involved in projects to reduce its ecological footprint, taking concrete measures to reduce its CO2 emissions. These measures are being taken throughout our company buildings, concerning business trips, in the paper goods we use, and in the use of only environmentally-friendly products (gift boxes, shopping bags, User Guides, gift wrap, etc.).


text:
My 2-and-a-half-year-old son, Owen, is not the bravest little boy you will ever meet.
We were reminded of this three different times this week: at the warm water therapy pool, the park and the place where you go bounce on the germ-infested jumpy castles while praying that nobody gets strep.
He was nervous going in the WARMEST WATER EVER - with his dad. Nervous being in the swing - with me right there. Nervous on the blow-up slide - with his dad.
After their trip down the slide, I asked Owen "Did you have fun?" He said, "Yes." Then I said, "Do you want to do it again?" He said "NO!" and ran over to the smaller, one-level, very square (boring to our daredevil daughter) jumpy castle and jumped to his heart's content.
I realize this may or may not be an indicator of how he will be his whole life, but for right now, this mama's heart and anxiety level are enjoying the fact he's not quite a daredevil.
Olivia, our daughter, has always been the one to push herself and try lots of things that make me smile through gritted teeth. I was afraid a little boy would be even more so this way, but our sweet Owen is more content sitting back, observing, and taking things slowly and carefully.
Then, I took the kids to a really healthy breakfast at McDonalds not too long ago. Our McDonalds recently had a play place renovation and Olivia was having a ball exploring the new features. She was up at the top of all the climbing plastic tunnel things before I knew what had happened. Owen went up a couple stairs but then turned around and was watching what his sister ("Kiki," he calls her) was doing.
As Olivia came down the new slide, Owen was standing there waiting for her and he cheered louder for her than I thought possible.
"Yay, Kiki!!!! You DID it!" all while clapping his hands and jumping up and down. For probably 20 minutes, she went up the tunnels and he waited patiently at the bottom of the slide, cheering her on with every successful run.
The interesting thing about it is that with every trip down the slide, Olivia got more and more excited...more and more confident...and faster! She looked expectantly for Owen at the bottom and reveled in his cheers. She enjoyed his cheers as much as she enjoyed coming down the slide. One time, he had come over to me for a drink of water and missed her grand exit from the slide. She was disappointed. "Owen! Where are you?" she said.
So then my mind got to over-analyzing (I told you, I do that too much) and I got very emotional in the McDonalds play place watching my little boy be his sister's biggest cheerleader. He was perfectly content. She was perfectly content. And I realized how big of a deal it is to have somebody cheering you on.
Moms, cheer for your kids! Even in the silly little things. Cheer for your spouse! Even when they drive you crazy. Whose team are you on? Who are you cheering for and who is cheering for you?
One thing I know is that being a mom can be incredibly isolating at times. It's hard to feel like there's anybody cheering for me, even if objectively I know I have great support.
I want to reassure you there's one Really Big Cheerleader that sees everything you do, Mom: God. He sees every shirt you fold. He sees every tear you dry. He notices every time you trip over the dog to try to clean up the latest mess. He notices when you use your shirt sleeve to get the snot off your kid's face. He remembers the last time you showered (even if you don't) and He doesn't care if you smell funky. He is there. If you can quiet your mind, the kid's toys and "Sesame Street" in the background, you will hear the quiet whisper of His voice cheering you on. The more familiar you become with the voice, the more it may start to sound like Owen's vociferous cheers at the bottom of the McDonald's slide.
I am so thankful for my cautious little boy and free-spirited, brave little girl who remind me over and over again that there are bigger truths to be found in the muck of motherhood. I hope I can be as big of a cheerleader for both of them as they are for me. And whenever I feel invisible, I hope I will remember to look up to The One Cheerleader who matters - and bask in His unconditional love and praise!
Allyson Zadeh is married with two children and another on the way. Read her Wednesdays on Greeley Moms.
One thing I know is that being a mom can be incredibly isolating at times. It\'s hard to feel like there\'s anybody cheering for me, even if objectively I know I have great support.

subset: commoncrawl


text:
Aaron Collins's legacy of generosity continues, a year after his death.
The Kentucky man, who died July 7, 2012, at 30, asked his family in his will to give out $500 tips as his last wish. When they didn't have the funds to make it happen, they took his request online where generous supporters helped out. Donations amounting to close to $60,000 quickly amassed.
Last week, ABC News reported, Aaron's brother Seth Collins handed out the 54th $500 tip from the Aaron's Last Wish fund to Indianapolis waitress Beth Foster, who is a server at the city's Thre3e Wse Men Brewing Co. She was stunned by the gesture on July 2 but told TV station WRTV that the timing was wonderful.
"It couldn't have come at a better time in my life," Foster said. "I'm a teacher just looking for a job and it's kind of hard right now."
Seth Collins said his goal is to travel to all 50 states and surprise someone with a large tip each week. Indiana is his 17th state after visiting Zeus Coney Island in Lansing, Mich., for surprise No. 53. He's writing about his experiences on a blog devoted to the mission and his road trips, which keeps his brother's memory alive.
In spite of losing Aaron, spreading his generosity adds to happy memories, he said. He'll keep on until the fund runs dry.
"It never gets old," Seth Collins said. "I knew about the third one that it was never going to get old."
$500 Tip Giveaway Continues a Year After Kentucky Man's Generous Final Wish
inset: Courtesy Aaron Collins Organization


text:
Philadelphia, PAUSA
May 13, 2013
No answer yet
No introduction yet
Help support your Meetup
For those young, energetic, adventurous and excited to be alive! We would like to meet regularly for events that promotes fun and active lifestyle. No competitive components but lots of social components to all of our activities.
Events are posted on request. View Event Calendar here: http://www.meetup.com/SportsNFun/events/
Please throw new ideas @ http://www.sportsnfun.info/events/making/ , spark interest and find who wants to join. If 3 people RSVP the event gets announced. If you are interested in helping us please email organizers.
Most events will be held in westerns suburbs of Philadelphia and open to all skill levels including beginners. Events may feature the following activities: Volleyball *Tennis *Picnic *Dining *Biking *Hiking * Skiing *Boating *Bowling *BBQ *Game Nites *Dancing..and anything else you like to see posted. You come, take ownership and participate.
Please be aware that we do meet frequently and may sent multiple emails every week. Use http://www.sportsnfun.info/settings/ to update your email settings. This is an information sharing website not an organization. Meetup.com Terms and Conditions apply.
Organizers pay the meetup dues making it free for you to join and participate. You are encouraged to contribute to meetup fees @ https://secure.meetup.com/SportsNFun/contribute/ Organizers are volunteers. Please don't forget to offer help/thank them.
We look forward to seeing you soon. We do request that you have a legit name and non cartoon picture of yours before you RSVP to any events.
2,090 Mountain Bikers
3,213 H3O Adventurers
5,141 Adventurers
1,674 International Students & Workers
6,117 Outdoor Enthusiasts
4,145 Party Peeps
Meetup members, Log in
By clicking "Sign up" or "Sign up using Facebook", you confirm that you accept our Terms of Service & Privacy Policy


text:
Plans for sewage treatment getting backed up in Hanoverton
February 18, 2013
HANOVERTON — Village Council could be facing its own Kobayashi Maru moment in regard to construction of a state-mandated sewage treatment plant....
The insanity of BIG government at its best. The EPA is the most radical, out-of-control bureaucracy we have. If I was Hanoverton I would dissolve today (but it is actually the EPA that should be dissolving).
0 Agrees | 2 Disagrees | Report Abuse »
Showing 1 of 1 comments
Post a Comment
You must first login before you can comment.


text:
Top Definition
An alias for double underscore, "__". Specially useful in the Python computer language, in which names like "__init__" are common. Coined as a speech shorthand.
Eric: So the problem is initdata? (the method initdata() )
John: Nope, dunder init dunder is where things start to go wrong... (__init__)
John: Nope, dunder init dunder is where things start to go wrong... (__init__)
додав ajaksu 22 Травня 2006
Trending Now
Can you define these popular missing words?
Dunder is a combination of the words dirty underwear.
"make sure to wash your dunders" "Dunderwear, clothes for the working man" "Dunderwear soft enoughf for a mans buttox, toughf enough to handle the swamp ass of a working man"
додав Heyballookey2 22 Жовтня 2008
A person who is utterly useless and incoherent. The IQ of this person almost always matches, or is close to, that of an average person's shoe size.
Dunder was unable to click the cube because his bandage was in the way.
додав DDunder 28 Червня 2007
The dregs from a rum barrel.
"I got sloshed from drinking the dunder." Hince the phrase, "He's a dunderhead."
додав Mark Dunder 04 Серпня 2003
Polite word for fart.
What that a dunder, Geoffery?
додав Its Calum! 26 Травня 2008
Another word for drunk, or just really intoxicated.
Damn, i'm gonna be so dunder after this beer bong.
додав Chase 03 Серпня 2003


text:
Hot Links: Government told to pay for traffic-jam alerts, even though taxpayers subsidized system
A decade ago, federal transportation officials hired Traffic.com to install high-tech sensors that measure freeway speeds and volume. The data can trigger traffic-jam alerts to electronic signs and other equipment.
But state and local governments can't post the alerts unless they pay the contractor a fee, The New York Times reports today, citing a non-yet-public audit by the U.S. Department of Transportation's inspector general.
Never mind that taxpayers have committed more than $50 million to the project.
The transportation department responded to the audit, according to Times, by citing "nine letters from members of Congress — many of whom had received frequent campaign contributions from executives at Traffic.com — who demanded, among other requests, that it skip a competitive bidding process and give more money to Traffic.com."
The story does not identify the politicians. It says Traffic.com, a subsidiary of Chicago-based Navteq, didn't respond to a request for comment.
In case you're wondering, yes, Traffic.com alerts do appear on dallasnews.com.
Do you have a tip about traffic? Government contracts? Send me an e-mail and let me know. Or join the conversation by commenting below.
If you're on Twitter, follow our blog at DMNInvestigates. You can also check us out on Facebook.


text:
quote: I'm happy about it but for 90% of us this won't even affect us.
quote: Frankly, if the 'majority' doesn't use more than 250Mbyte - or 5Gbyte - then it shouldn't be a problem that a few people does.
quote: Since the "air" is a shared medium if lots of people start downloading porn at the same time, users that only want to make a VOIP call or require low bandwidth but low latency and jitt are in big trouble.
quote: This would be achievable by a multi-tiered Leaky bucket system, for example.
quote: Why should everyone else have to pay into your heavier internet use? Also, what's so hard about understanding that if a lot of people want to use more, then that is going to cost more too?
quote: No one is subsidizing anyone, the ISP's advertised "Unlimited" at a certain price point, hence that is what you should be entitled to.
quote: Secondly... If it's a case of congestion with the backhaul and international links, then they should increase capacity, or turn on some of the dormant fiber that they have lying around.
quote: Seriously, I'm all for bandwidth caps, provided they still keep the unlimited plans at the same price point, but introduce caps at LOWER price points so those who only use say... 1gb a month could save a bit of money.


text:
COMPUTER SECURITY: The S.C. Tech Academy of the Coastal Community Foundation holds a four-part class, "Computer Security 101" for nonprofit staffers, board members and volunteers. 9–11 a.m. weekly through April 30. 635 Rutledge Ave., Suite 201, Charleston. $59. Registration required. Go to www.sctechacademy.org for more information or to register.
A/C ENGINEERS: The American Society of Heating, Refrigerating and Air Conditioning Engineers meets. 5:30 p.m. Harbor Breezes, 176 Patriots Point Road, Mount Pleasant. $25. Email email@example.com for more information.
PERSONAL FINANCE: The National Foundation for Credit Counseling, Family Services and TD Bank hold a free personal finance workshop: "Credit Cents." 6 p.m. 4925 Lacross Road, Suite 105, North Charleston. Contact Kristin Glantz at firstname.lastname@example.com or 735-7842 to register.
BUSINESS ROUNDTABLE: The coastal chapter of SCORE holds an open roundtable for area business owners and entrepreneurs. 9 a.m. 4500 Leeds Ave., North Charleston. Free and open to walk-ins. Call 727-4778 for more information.
BUSINESS COUNSELING: The coastal chapter of SCORE offer free, confidential business counseling for entrepreneurs and small business owners. 10 a.m.–1 p.m. Charleston County Main Library, second floor, 68 Calhoun St., Charleston. No appointment necessary. Call 727-4778.
Making Ends Meet: The National Foundation for Credit Counseling, Family Services and TD Bank hold a free personal finance workshop: "Making Ends Meet." 6 p.m. 4925 Lacross Road, Suite 105, North Charleston. Contact Kristin Glantz at email@example.com or 735-7842 to register.
BERKELEY CHAMBER MEETING: The Berkeley Chamber of Commerce holds its annual meeting. 6:30 p.m. Daniel Island Club, 600 Island Park Drive, Daniel Island. $75 for members; $100 for others. Call 577-9549 or 761-8238 or go to www.berkeley sc.org to register online.
HONORING EDUCATORS: The Berkeley Chamber of Commerce holds its 2013 Teacher of the Year breakfast. 7:30 a.m. Trident Technical College Complex for Economic Development, 7000 Rivers Ave., Bldg. 920 North Charleston. Call 577-9549 or 761-8238 or go to www.berkeley sc.org to register online.
April 17
LEGAL TALK FOR BUSINESSES: The coastal chapter of SCORE holds a workshop on the advantages and disadvantages of various legal structures, partnerships, contracts and leases. 6-9 p.m. College of Charleston's Towell Library, 66 George St. Scheduled speaker is attorney John "Skip" Martin. $25. Register at www.score285.org or by calling 727-4778.
April 18-19
QUALITY CONFERENCE: The Lowcountry section of the American Society for Quality holds its 2013 Lowcountry Quality Conference. Theme: "The Role of Quality in the Lowcountry's Future." Sheraton Charleston Airport Hotel, 4770 Goer Drive, North Charleston. Scheduled: Jeffrey Jones, quality director for Boeing in North Charleston. Topic: "The Future of Quality at Boeing. $79-$160 before April 1; $89-$179 afterward. Go to 123signup.com/register?id=bmnhh to register. Call Dean Creed at 761-8000, ext. 4773, for more information.
April 19
CORPORATE LEADERSHIP FORUM: The Citadel and the National Association of Corporate Directors hold the fourth annual Citadel Directors' Institute to explore leadership issues related for corporate board members and top executives. 6:45 a.m.-4:45 p.m. Charleston Place Hotel. Keynote speaker is James Rogers, CEO of Duke Energy. For details, email firstname.lastname@example.com or call Wesley M. Jones Jr. at 953-7531.


text:
If you are a pet owner / dog walker / bird hunter please familiarize yourself with removing a pet or hunting dog from a trap. There is a great brochure put out by the Linclon co. humane society on this subject and I'll add the link to their PDF here:
No matter your views on trapping this is info that every dog owner should know. Todays foot-hold restraint traps are not damaging to animals, do not have "teeth", and are not inhumane in anyway. We all share the woods and trappers are a part of this. I have had to do this and I encourage everyone to read it. If your dog is caught there is no reason to panic..everything will be fine.
If you do read the link, please note that wisconsin has several laws that virtually eliminate all dog encouters with "conibear" traps and wisconsin also has outlawed any locking devices on "snares." Our state has gone a long way to keep dogs safe, we have more stringent laws than most other states.


text:
Contact Us
We are international
• about myeloma
newly diagnosed?
10 steps to better care®
Ask Dr Durie
• treatment options
frontline therapy
novel therapies
bone disease
stem cell transplant
treatment at relapse
clinical trials
supportive care
myeloma matrix
drugs In development
• health professionals
Black Swan Research Initiative®
Brian D. Novis Research Grant
clinical trials
International Myeloma Working Group
IMWG conference series
nurse leadership board
Asian Myeloma Network
global clinical trials forum
seminars & meetings
meeting highlights
Kyle lifetime achievement award
• support
toll-free InfoLine
support groups
online support forum
IMF Videos
Ask Dr. Durie
webcasts from patient & family seminars
webcasts from medical meetings
imwg conference series
nlb webcasts
imf webcasts
Living Well With Myeloma
Myeloma Voices
• meetings
patient & family seminars
community workshops
international seminars
event calendar
• advocacy
Health Care Resources
IMF advocacy
Action Center
Myeloma Action Team
Global Myeloma Action Network (GMAN)
latest news and info
public policy statements
Advocacy Update
contact us
• fundraising
make a donation
major giving
planned giving
tributes and memorials
annual comedy celebration
the hope society
1000 cranes of hope
shop for the imf
buy imf merchandise
donate your vehicle
contact development
• blogs
Dr. Durie's Blog
IMF at ASH 2015
myeloma voices
• about imf
about us
people of IMF
international partners
imf funded research
imf grant application
press & media
contact us
newly diagnosed?
10 steps to better care®
Ask Dr Durie
frequently asked questions
other resources of interest
step 1: get the correct diagnosis
step 2: tests you really need
step 3: Initial treatment options
step 4: supportive care
step 5: transplant
step 6: response assessment.
step 7: consolidation/maintenance
step 8: monitoring
step 9: relapse
step 10: new trials
• about myeloma
Spring 2004 Volume 5, Issue 10:
Drug Resistance: Overcoming Multiple Myeloma Drug Resistance by Inhibiting the Proteasome
By Robert Orlowski, MD, PhD
There are many difficult hurdles to overcome in the treatment of multiple myeloma, but one of the most important is a phenomenon called drug resistance.
There are many difficult hurdles to overcome in the treatment of multiple myeloma, but one of the most important is a phenomenon called drug resistance (recently reviewed in (1)). Myeloma cells that have this property can evade the effects of many chemotherapy drugs, allowing them to survive and even flourish in the face of such treatment. The impact that such drug resistance can have on the outcome of therapy may be seen in many different ways. Some patients have disease that, when it is first treated with chemotherapy, does not respond well, and occasionally may even progress, which is sometimes called primary refractory disease. If this happens, patients are usually switched to a different chemotherapy regimen, which hopefully is more effective. Other patients have disease that responds well and may even enter a complete remission, but after some period of time the disease relapses, and they need additional therapy. This usually occurs because a small fraction of the original myeloma cells were resistant to treatment, and once the majority that were sensitive were killed by chemotherapy, the remaining resistant cells had room and space to grow. Finally, many patients receive several different treatments for their disease, and may find that each successive regimen results in a briefer, and less dramatic benefit. One reason that this occurs is that some of the resistance pathways are active against several drugs, and therefore myeloma cells may survive therapy with one agent because a previous therapy activated a resistance mechanism that blocks the action of both. Fortunately, there are new ways emerging to overcome such drug resistance that may improve the effectiveness of myeloma therapy, but first let's look at the molecular mechanisms by which this whole process occurs.
Inherited Chemoresistance
In thinking about the mechanisms of chemotherapy resistance important in myeloma, it is convenient to divide them up into several categories. The first is inherited chemoresistance, which is something that is present right from the beginning in the very first myeloma cell, and is passed down to all of the cells that arise later. Sometimes this genetic change may even contribute to the process of cancer formation itself. An example of this is the so-called Bcl-2 protein, which is expressed at higher levels than normal in plasma cells from many patients with myeloma. This protein is usually found in the membrane of mitochondria, which are the energy-generating organelles of cells. One of the ways that chemotherapy and radiation kills cells is by damaging mitochondria and inducing them to release a protein called cytochrome c into the cytoplasm, which then activates a process known as apoptosis, or programmed cell death. Bcl-2 is found in the membrane of mitochondria, and is thought to work against apoptosis by preventing the release of cytochrome c. Cells that overexpress Bcl-2 are resistant to a variety of therapies used in multiple myeloma, including anthracyclines like doxorubicin, alkylating agents like melphalan, and also steroids like dexamethasone. Such overexpression can account for the resistance of myeloma cells to the first therapy that they receive.
Acquired Chemoresistance
Another mechanism of resistance can be called acquired chemoresistance, because it is not present in every cell from the beginning, but appears in cells only after therapy has begun. An example of this is the so-called P-glycoprotein, which is not often found in myeloma cells initially, but after some types of chemotherapy its expression increases, and may be seen eventually in all plasma cells. The P-glycoprotein has a useful normal function, which is to recognize toxic chemicals in the cell and, from its position in the cell membrane, to pump them out, thereby saving the cell from damage. Unfortunately, many of the chemotherapy drugs used against multiple myeloma are also recognized as being toxins by this pump. By removing them from myeloma cells, the P-glycoprotein reduces the chances that the drugs will have their intended effect. Cells that overexpress P-glycoprotein are resistant to drugs such as doxorubicin and vincristine. Such overexpression can account for the ability of myeloma cells to resist treatments that they haven't previously been exposed to, because the P-glycoprotein acts against many drug classes.
Inducible Chemoresistance
One last mechanism can be called inducible chemoresistance, and is one of the more recently described ways that this process of resistance can occur. Chemotherapy drugs are typically thought of as only killing cancer cells, but in fact they have many effects, and sometimes can actually activate signals that promote the survival of cells. This can be a desired outcome, because it may decrease the toxicity of some drugs against normal cells, thereby minimizing side effects to the patient. However, it can also be harmful, because if it promotes the survival of cancer cells then the drugs have actually decreased their own effectiveness against the tumor. In multiple myeloma one of the most important of these mechanisms is the so-called nuclear factor kappa B (NF-kB). When activated, NF-kB opposes apoptosis in a number of ways, one of which is by inducing a family of proteins called IAPs, or inhibitors of apoptosis. These proteins are able to slow the process of cell death stimulated by chemotherapy and radiation by binding to proteins called caspases, which are the catalysts that carry out the cell death program. NF-kB is activated in cells treated with drugs that are active in multiple myeloma, such as doxorubicin and melphalan, and also by other treatments, such as radiation. Since NF-kB is found in all myeloma cells, it can contribute to resistance to chemotherapy at every stage of the disease process.
The approval in May of 2003 of the drug bortezomib (Velcade®; formerly known as PS-341) by the Food and Drug Administration after positive results against multiple myeloma in Phase-I (2) and II (3) clinical trials was an exciting development. This drug works by inhibiting the proteasome, which is a large complex in cells that is responsible for removing damaged proteins, and also proteins that have already served their purpose for the cell and are no longer needed (reviewed in (4)). Bortezomib, made by Millennium Pharmaceuticals, was approved for treatment of patients who have had at least two prior therapies, with progression of that disease on the last of these. Its ability to induce a complete remission in 10% of patients, and either a complete or partial response in 27%, was very encouraging (3). In addition, the drug was able to double the time to disease progression in patients with multiple myeloma compared to whatever had been their previous therapy. This is different than the usual trend with additional chemotherapy regimens for briefer durations of benefit, as described above. Perhaps most exciting about this drug, however, are studies that show bortezomib can help to overcome all of the mechanisms of chemotherapy resistance described above.
How Velcade® Counteracts Drug Resistance
Laboratory studies of cells that overexpress the Bcl-2 survival protein showed that exposure to bortezomib resulted in both phosphorylation of this protein and also cleavage into small fragments (5). This reduces the Bcl-2 level in cells, and likely makes them more susceptible to chemotherapy, which accounts in part for the ability of bortezomib to induce apoptosis independent of Bcl-2 status. With regard to the P-glycoprotein pump, studies have shown that function of the proteasome is needed for normal P-glycoprotein to be made (6, 7). When the proteasome is inhibited, abnormal immature forms of this protein accumulate which cannot pump chemotherapy drugs from the inside to the outside of cells. Since this results in greater levels of these drugs inside cells, it could enhance the ability of these drugs to kill myeloma cells. Finally, in terms of NF-kB, proteasome inhibitors work at several steps of this pathway, and block both the ability to make some parts of the NF-kB transcription factor (8), as well as its ability to move into the nucleus, where it activates proteins such as IAPs that block apoptosis. Based on just these findings alone, there would be excitement about the possibility that bortezomib could enhance the anti-tumor efficacy of standard chemotherapy drugs used in myeloma
Drug Synergy
Even more optimistic are laboratory studies looking at the ability of combinations of drugs including bortezomib to kill myeloma cells. In the first pioneering work that showed the promise of bortezomib against myeloma in the laboratory (9), investigators were able to show that the addition of steroids caused more cell death than either of the two drugs by themselves. This is called drug synergy, and is not always found between drugs, because some combinations will actually antagonize each other and cause less cell death, possibly compromising their clinical efficacy if they were tried in patients. Also, cells that had previously been resistant to steroids were once again able to be killed by these drugs when they were added in combination with bortezomib. Other drugs that are used in patients with multiple myeloma have been tested with similar results (10-12), showing synergistic cell killing, and also the ability to kill previously drug-resistant cells. These studies included agents such as melphalan, doxorubicin, and immunomodulatory analogs of thalidomide, and strongly supported the testing of such combinations in patients with multiple myeloma.
Velcade® Plus Melphalan
Based in part on the laboratory studies described above, several drug combinations either are being tested, or already have been, with a focus on myeloma, one of which is the combination of melphalan and bortezomib (13). Melphalan is also called Alkeran®, and is made by Celgene Corporation. In the most recent update of these results, presented at the December meeting of the American Society of Hematology (ASH), Yang and colleagues showed the outcome in the first 15 patients treated. From a side effect standpoint patients tolerated the drugs well, probably due in large part to the fact that the first dose level used melphalan at 0.025 mg/kg, which is one-tenth the dose used in the melphalan/prednisone combination, and bortezomib was used at 0.70 mg/m2/dose, or about one-half of the approved dose of 1.30 mg/m2. Ten patients had responses, including five with partial responses, meaning that there was a 50% decrease in measurable disease burden, and some of these included patients who had previously received melphalan.
Velcade® Plus Thalidomide
Another combination that has been studied is that of thalidomide and bortezomib (14). Thalidomide is also called Thalomid®, and like melphalan is also made by Celgene Corporation. At the ASH meeting last December results from the first 56 patients treated were presented, all of whom had relapsed after transplantation, and 81% of whom had previously received thalidomide, to which their disease had become resistant. Zangari and colleagues noted that the combination was well-tolerated, and while peripheral neuropathy was a frequent event, it generally was mild to moderate, and not severe. This is important because peripheral neuropathy is a known complication of both thalidomide and bortezomib by themselves, and one concern about combining them would be that patients would have even more of this problem. Neuropathy is caused by damage to the nerves and can present in many different ways, including numbness, tingling, burning, and pain, especially in the extremities, and sometimes can cause weakness and even impair the ability to perform activities of daily living. If such symptoms occur patients and their healthcare providers generally choose either to decrease the doses of the responsible drugs, or in more severe cases to stop the drugs altogether. There are also supportive care measures that can be used, such as supplementation with vitamins like B-complex, including B6, vitamin E, and folic acid, and also some prescription medications, like gabapentin (Neurontin) and Elavil. Neuropathy can improve over time once the drugs causing it are stopped, but the time course can be very long, and may take weeks to many months. Also, since nerve tissue does not regenerate or heal well, some patients may be left with a residual, permanent neuropathy. In addition to these findings on neuropathy from this study, more impressive was the fact that 22% of patients had a complete response, and 57% had either a complete or partial response. Such responses occurred even in patients whose myeloma had deletion of chromosome 13, which is usually a poor prognostic sign that predicts a worse response to most therapies than patients without this cytogenetic abnormality. Finally, the response rate was reported to be the same in patients receiving bortezomib at 1.0 mg/m2/dose and the lowest dose of thalidomide, 50 mg per day, compared with those receiving higher doses up to 200 mg of thalidomide daily. This is important because it suggests that it might be possible to reduce the doses of the drugs given to patients with comparable, or maybe even enhanced efficacy, and such reductions will make the drugs better tolerated.
Velcade® Plus DOXIL®
The last two-drug combination that was presented at ASH used bortezomib and pegylated, liposomal doxorubicin (15). This drug, better known as Doxil®, is made by Tibotec Therapeutics, and is a different preparation of the standard drug doxorubicin. Pegylated liposomes are lipid bilayers similar to cell membranes, and the doxorubicin is contained inside these structures. There are several advantages to this formulation compared with regular doxorubicin. One of these is that because the drug is released very slowly from the liposomes, it can be given intravenously over one hour, but stays in the body over a long period of time, similar to the effect of a continuous infusion of doxorubicin like many patients receive with the standard "VAD" regimen. Because of this, patients do not need either a central line for these infusions of doxorubicin or an infusion pump, and instead can receive Doxil® through a regular peripheral intravenous line. Also, the drug appears to be less toxic to the heart than standard doxorubicin which, if given at a cumulative dose in excess of 550 mg/m2, can cause a so-called cardiomyopathy, with decreased heart function that in severe forms causes congestive heart failure. In this study, which was done at our institution, bortezomib was given as an intravenous bolus dose on days 1, 4, 8, and 11 of a 21-day cycle in a range of doses, though the final study recommendation will be to start with 1.3 mg/m2/dose. Doxil® was given on day 4 about one hour after the bortezomib at a fixed dose of 30 mg/m2. Patients tolerated the combination well, and the side effects were those that would be expected if either drug were used alone. Side effects that were seen in at least 25% of patients included fatigue, thrombocytopenia (low platelet count), nausea, constipation, anemia, neutropenia (low white cell count), decreased appetite, diarrhea, neuropathy, and mucositis, or mouth sores. Responses with at least a 50% reduction in disease burden were seen in 73% of patients, with 36% having a complete response. Of particular interest is that there were 13 myeloma patients on the study who had previously received either standard doxorubicin or Doxil® itself, and whose disease had either progressed despite this therapy, or at best not responded and remained stable. Out of these 13 there were complete responses in 5 and partial responses in 3, suggesting that bortezomib was indeed able to reverse resistance to doxorubicin in at least some of these patients. Also encouraging is the fact that of the two patients who went on to transplant after this treatment, both were able to have good numbers of stem cells collected, suggesting that this combination does not damage stem cells and does not close the door to later transplantation.
Avenues for Further Research
All of these studies have so far been done only at single institutions, and the number of patients treated has been modest, so larger trials done at many centers will be needed to confirm these preliminary results. Several such studies are already being planned, and hopefully some of the results will be available soon. None of the combinations have yet been tested head-to-head in a randomized fashion, which is the best way to compare them directly, so it is not possible to know which is better, or if one is better for some patients while others may benefit from another. Other two-drug combinations based on bortezomib are being tested as well, including one trial of the thalidomide analog CC-5013, which is also known as Revlimid, and made by Celgene Corporation. Finally, some investigators are looking at three-drug combinations, hoping that there would be a further improvement in efficacy. Thus, there certainly remains much work to be done in this area. Also, it should be pointed out that there are many other agents being studied that also may be able to overcome drug resistance in multiple myeloma. One good example is oblimersen, or Genasense, being developed by Genta Incorporated, which is an anti-sense oligonucleotide that decreases levels of Bcl-2 protein.
However, there are many encouraging results that have been obtained so far from the bortezomib studies described above. The overall and complete response rates of some of the bortezomib-based combinations appear to be higher than what would be expected with either bortezomib alone, or with the standard chemotherapy agent alone. This supports the possibility that the drugs are acting synergistically to kill myeloma cells. Some patients with disease that was previously resistant to the standard chemotherapy have had significant responses, including many complete responses, to the combination of this same agent and bortezomib. This supports the possibility that bortezomib is able to overcome drug resistance. Also, the fact that some of these responses occurred at doses that were less than what would be considered standard is encouraging. If lower doses can be used, side effects will be decreased, and more people will hopefully benefit from therapy because fewer patients will need to stop treatment due to drug-related toxicities.
What This Means to You
What does all this mean for patients with myeloma, their families, and their health care providers? First of all, these combination regimens will be tested in additional trials, and by enrolling in these studies patients can have access to cutting-edge medicine using drugs that are known to have benefits against multiple myeloma. Only by doing such studies and collecting and analyzing the data will we be able to know which combinations work best and, possibly, which regimen is better for which type of myeloma patient. This may lead ultimately to the ability to predict ahead of time which therapy would be best for each patient as an individual. For those patients who do not have access to such trials, however, since all of these drugs are FDA-approved, it is possible to receive this therapy without enrolling on a clinical study. While these regimens will probably not be the cure for multiple myeloma, they may represent a new concept in the treatment of this disease. In the older paradigm, patients were treated with certain drugs, but once their disease no longer responded that drug was never reused, because the myeloma cells retained their drug resistance to that agent by passing those genetic characteristics on to their progeny. With the availability of drugs such as bortezomib, which seems able to overcome such resistance, this treatment paradigm may need to be changed. Patients whose disease was resistant to thalidomide or doxorubicin were able to have significant responses to these agents in combination with bortezomib, as noted above. Thus, it may now be possible to overcome the resistance of myeloma cells and recapture drug sensitivity, allowing the beneficial reuse of agents which would previously have not been considered options for patients because of prior exposure. As a result, the number of treatment options available to patients may be dramatically increased, which is the next best thing to a cure. Furthermore, the enhanced complete response rates suggests that such combinations will improve survival, and ultimately may form part of a multidisciplinary approach that will bring us closer to the cure for this disease.
1. Yang, H. H., Ma, M. H., Vescio, R. A., and Berenson, J. R. Overcoming drug resistance in multiple myeloma: The emergence of therapeutic approaches to induce apoptosis. J Clin Oncol, 21: 4239-4247, 2003.
2. Orlowski, R. Z., Stinchcombe, T. E., Mitchell, B. S., Shea, T. C., Baldwin, A. S., Stahl, S., Adams, J., Esseltine, D. L., Elliott, P. J., Pien, C. S., Guerciolini, R., Anderson, J. K., Depcik-Smith, N. D., Bhagat, R., Lehman, M. J., Novick, S. C., O'Connor, O. A., and Soignet, S. L. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol, 20: 4420-4427, 2002.
3. Richardson, P. G., Barlogie, B., Berenson, J., Singhal, S., Jagannath, S., Irwin, D., Rajkumar, S. V., Srkalovic, G., Alsina, M., Alexanian, R., Siegel, D., Orlowski, R. Z., Kuter, D., Limentani, S. A., Lee, S., Hideshima, T., Esseltine, D.-L., Kauffman, M., Adams, J., Schenkein, D. P., and Anderson, K. C. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med, 348: 2609-2617, 2003.
4. Voorhees, P. M., Dees, E. C., O'Neil, B., and Orlowski, R. Z. The proteasome as a target for cancer therapy. Clin Cancer Res, 9: 6316-6325, 2003.
5. Ling, Y. H., Liebes, L., Ng, B., Buckley, M., Elliott, P. J., Adams, J., Jiang, J. D., Muggia, F. M., and Perez-Soler, R. PS-341, a novel proteasome inhibitor, induces Bcl-2 phosphorylation and cleavage in association with G2/M phase arrest and apoptosis. Mol Cancer Ther, 1: 841-849, 2002.
6. Loo, T. W. and Clarke, D. M. Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions. J Biol Chem, 273: 14671-14674, 1998.
7. Loo, T. W. and Clarke, D. M. The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: Potential for a role in cancer chemotherapy. FASEB J, 13: 1724-1732, 1999.
8. Palombella, V. J., Rando, O. J., Goldberg, A. L., and Maniatis, T. The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell, 78: 773-785, 1994.
9. Hideshima, T., Richardson, P., Chauhan, D., Palombella, V. J., Elliott, P. J., Adams, J., and Anderson, K. C. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res, 61: 3071-3076, 2001.
10. Mitsiades, N., Mitsiades, C. S., Poulaki, V., Chauhan, D., Richardson, P. G., Hideshima, T., Munshi, N. C., Treon, S. P., and Anderson, K. C. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications. Blood, 99: 4525-4530, 2002.
11. Ma, M. H., Yang, H. H., Parker, K. M., Manyak, S., Friedman, J. M., Altamirano, C. V., Wu, Z. Q., Borad, M. J., Frantzen, M., Roussos, E., Neeser, J., Mikail, A., Adams, J., Sjak-Shie, N., Vescio, R. A., and Berenson, J. R. The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res, 9: 1136-1144, 2003.
12. Mitsiades, N., Mitsiades, C. S., Richardson, P. G., Poulaki, V., Tai, Y.-T., Chauhan, D., Fanourakis, G., Gu, X., Bailey, C., Joseph, M., Libermann, T. A., Schlossman, R., Munshi, N. C., Hideshima, T., and Anderson, K. C. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications. Blood, 101: 2377-2380, 2003.
13. Yang, H. H., Swift, R., Sadler, K., Vescio, R., Adams, J., Schenkein, D., and Berenson, J. R. A phase I/II trial of VELCADE and melphalan combination therapy for patients with relapsed or refractory multiple myeloma. Blood, 102: 235a, Abstract 826, 2003.
14. Zangari, M., Barlogie, B., Jacobson, J., Rasmussen, E., Burns, M., Kordsmeier, B., Shaughnessy, J. D., Anaissie, E. J., Thertulien, R., Fassas, A., Lee, C.-K., Schenkein, D., Zeldis, J. B., and Tricot, G. VTD regimen comprising Velcade (V) + thalidomide (T) and added dex (D) for non-responders to V + T effects a 57% PR rate among 56 patients with myeloma relapsing after autologous transplant. Blood, 102: 236a, Abstract 830, 2003.
15. Orlowski, R. Z., Voorhees, P. M., Garcia, R. A., Hall, M. D., Lehman, M. J., Johri, A., Humes, E., Adams, J., Esseltine, D. L., Gabriel, D. A., Shea, T. C., Van Deventer, H. W., Mitchell, B. S., and Dees, C. Phase I study of the proteasome inhibitor bortezomib in combination with pegylated liposomal doxorubicin in patients with refractory hematologic malignancies. Blood, 102: 449a, Abstract 1639, 2003.
Be the first to comment
Issue Contents
related articles
We thank our sponsors
Bristol-Myers Squibb
Celgene Corporation
Sanofi Oncology
Takeda Oncology
We welcome our international partners
Czech Republic
Latin America
12650 Riverside Drive, Suite 206 | North Hollywood, CA 91607-3421 | USA
InfoLine:800-452-2873 or 818-487-7455
©2015 International Myeloma Foundation.
• about myeloma |
• treatment options |
• health professionals |
• support |
• meetings |
• advocacy |
• fundraising |
• blogs |
• about imf |
Privacy Policy |
Annual Report |
Audit Report |
Federal Tax Form 990 |
Facebook |
Twitter |
YouTube |
Donor Privacy Policy |


text:
Don't Be Phished Like An Internet N00b
|Email Print
I received an email today from Comcast about how they recently changed their policy regarding accounts:
Comcast takes the security of our customers personal and account information very seriously. As part of our ongoing effort to ensure the security of our customers information, we have recently enhanced the security of the Comcast.com account management system.
As a result of these recent enhancements, if a Comcast.com account is inactive for 180 days, it is removed from our system.
In order to keep your Comcast.com account active, please log in today with your user name and password: www.comcast.com/login.
First off, anytime someone emails me to log into my account, I never click any links in the email. Never ever. I don't care if it's some stupid account on some random free email account that you wouldn't care gets stolen. The fact of the matter is that thieves know that people use the same username and password on multiple accounts so a free email account could yield a free bank account as well. Lastly, I can just go to Comcast.com directly and login there to confirm whatever.
Secondly, if this is legit, Comcast is ridiculously stupid because they should check to see if the account is connected to an active customer account (it is). If it is, then ignore this stupid little rule because they're obviously "active" because they're paying for service! If it's not connected, then I suppose you can request that someone log in every 180 days (though the chances of a non-Comcast subscriber caring about their Comcast account is exactly zero).
Moral of the story – Companies may be stupid and make legitimate but dumb requests, but don't be a dummy and get phished.
FYI, the email I received, according to the headers, was legitimately sent from a comcastonline.com's server but…
- The email was "from" a comcastsupport.com email…
- The link in the email was to to comcast.com…
- And the link itself was to gothere2.comcastonline.com…
Seriously Comcast, you gave me 2034982304938 reasons to think it was a phishing email (all they missed was the link going to thisisacomcastphishingemail.com).{ 10 comments, please add your thoughts now! }


text:
Oracle Enterprise Manager Ops Center is the industry's first converged hardware management solution for Oracle system environments—combining management across servers, operating systems, firmware, virtual machines, storage, and network fabrics into a single console, to maximize the value of infrastructure investments. With its end-to-end lifecycle management and built-in integration with My Oracle Support, Oracle Enterprise Manager Ops Center dramatically improves the efficiency of IT operations.
Now, through the Ops Center Everywhere Program, customers who maintain an Oracle Premier Support for Systems or Oracle Premier Support for Operating Systems agreement can download and use Oracle Enterprise Manager Ops Center to manage their covered Oracle systems at no additional cost. Oracle has already toppled the historic technical barrier between on-premise management software and online vendor support. With this program, we eliminate the cost barrier and open the door to a next-generation customer experience which is unique in the industry.


text:
The Tempest Alan Irvine directs FREE outdoor performances of Shakespeare's The The Tempest is a revenge play – but also about family, and, of course, romance – with comical results. PSIP serves up rough-and-tumble, contemporary Shakespeare plays using the parks' environs as the set and the audience as part of the action. Bring a blanket and be prepared as the show must go on in any kind of weather. 09/01/2012
Music Under the Stars Maestro André Raphel and the Wheeling Symphony with master trumpeter Rodney Mack present these annual free outdoor concerts: Sunday at the Anne Kuchinka Amphitheatre in Oglebay Park in Wheeling, and Monday at McQuain Riverfront Park in Morgantown, WV.09/02/2012
David Harrison, piano Pianist David Harrison plays favorite piano classics spanning nearly 200 years of great music.09/02/2012
Jersey Boys Jersey Boys is "Working Its Way Back" to Pittsburgh! It's the Tony, Grammy and Olivier Award-winning Best Musical about Rock and Roll Hall of Famers The Four Seasons. Watch how four blue-collar kids became one of the greatest successes in pop music history with such hits as "Sherry," "Big Girls Don't Cry," "Rag Doll," "Oh What a Night" and "Can't Take My Eyes Off of You."09/04/2012
Music of Golijov and Ljova Klezmer and gypsy inspired works including Asha, Love Potion, and Expired by Ljova (Lev Zhurbin), then The Dreams and Prayers of Issac the Blind by Osvaldo Golijov. Free admission. Donations welcome. Cash bar.09/05/2012
River City Swing Band The Downtown Pittsburgh Partnership's Farmers Maket Lunchtime Concert Series presents the River City Swing Band complete with a swing dance duo.09/06/2012
August: Osage County Winner of the Pulitzer Prize and the Tony Award for Best Play, Tracy Letts' August: Osage County is a wild ride that tells the story of the Westons, a hysterical yet horrifically dysfunctional clan that comes together at their Oklahoma home when the patriarch disappears. Forced to confront unspoken truths and secrets, the family must also contend with Violet, a pill-popping, deeply unsettled woman at the center of this storm. Directed by John Shepard.09/06/2012
First Fridays: Ancient Future The music of Ancient Future is an exhilarating fusion of exciting rhythms and exotic sounds featuring virtuoso musicians from around the globe. Their music combines contemporary jazz and rock with the irresistible rhythms of Africa, Bali, India, the Middle East and South America, the rich harmonies of European classical music, and the melodic knowledge of the whole world. 09/07/2012
The Dukes of Dixieland The best of traditional Dixieland jazz woven together pop. gospel and country. Bright, brassy and smooth, with more than 38 years of tradition behind them, the Dukes bring a time-honoredauthenticity to all of the hits of Dixie's yesteryear. "The audience is really in love with you."–Keith Lockhart, Conductor, Boston Pops Orchestra.09/07/2012
A Fair in the Park Over 100 regional and national American contemporary craft artists exhibit clay, textile, jewelry, metal, glass, wood and mised media works of art. Featuring creaft demonstrations, live music, performance art, kid's activities, and a variety of foods.09/07/2012
East Winds Symphonic Band The Saxonburg Arts Festival presents this East Pittsburgh-based community band in patriotic works including America the Beautiful, You're a Grand Old Flag and Armed Forces Salute; marches On the Mall and Americans We; Broadway favorites including Seventy-Six Trombones and selections from Chicago; plus movie music from Aladdin and by John Williams. Free admission.09/08/2012
Two Ballet Premieres The premiere of two ballets by founding directors Blake Ragghianti and Luke Mayernik, with orchestra conducted by Ryan Keeling and Alejandro Pinzon -- The Alkonost, with music by Mayernik, and Infinity, with music by Ragghianti. Choreography is by Alan Obuzor, Kelsey Bartman, and Pearlann Porter featuring Texture Contemporary Ballet Company and The Pillow Project. Mention WQED and get a 25% discount on tix, online or at the box office!09/08/2012
Board of Directors
WQED Management
WQED History
Driving Directions
The Studio on Fifth
WQED MultimediaStrategic Plan 2013-2018
WQED FCC Public File
Privacy Policy
Accessibility Information
Diversity Statement
Local Content & Service Report
WQED: The Create Channel 13.2
WQED: The Showcase Channel 13.4
Pittsburgh 360°
Filmmaker's Corner
QED Cooks
Rick Sebak Documentaries
Contact Us
Facility Rentals
Email this page
Make a Donation
Special Gifts
Corporate Giving
WQED Presents Club
Other Ways to Give
Planned Giving
© 2016 WQED Multimedia | All rights reserved
Follow @WQED
Programs produced by WQED Multimedia for broadcast by others comply with the captioning quality standards embodied in Section
79.1(j)(2) of the rules of the Federal Communications Commission.
Mail filtering provided by www.mxguarddog.com


text:
The City of Lake Oswego treats water by pumping raw (river) water from our Clackamas River intake at Gladstone, under the Willamette River to the Treatment Plant in West Linn. When the water reaches the plant it receives doses of chemicals that help to make it safe. Chlorine is added to begin the process of disinfecting the water. Alum (aluminum sulphate) is the primary coagulant. A coagulant is used to make the fine particles of silts, clays and other naturally occurring organic matter clump together to form larger particles called "floc". The larger floc particles then settle out of the water during the next treatment process called "sedimentation". The settled water is then dosed with a filter aid polymer, the type and amount of which varies by water temperature. The water flows into six dual media filters. The dual media is approximately 3 feet of anthracite coal and one foot of silica sand deep. It will last more than 30 years before the media needs replacement, but only 30 hours of use is possible before the filter needs to be washed.
To wash a filter, filtered water is pumped in reverse of the regular flow direction and accumulated dirt is washed out of the filter into sludge lagoons (not pictured). Washing a filter requires at least 50,000 gallons of water, which sounds like a lot, but considering that the filter provides several million gallons before it needs washing, it's literally a drop in the bucket.
After the water has been filtered, it must be made non-corrosive to materials that commonly make up home plumbing systems. At this point an addition of calcium (hydrated lime) is added to increase the pH of the water to between 7.2 and 7.6. It has been determined that this is our optimal level for corrosion control city-wide.
Also at this point a final addition of chlorine is made to ensure that the farthest areas of town have a minimum free chlorine residual of 0.2 ppm (parts per million). As the water is being pumped to town, a final measurement of pH is taken and a dose of carbon dioxide injected in order to ensure that the pH is within a very close tolerance of the required level.


text:
Wednesday, October 9, 2013
A suspect has been arrested in connection to the double homicide of a mother and daughter who were found dead Oct. 1 in their Sangaree home.
Jacob Theopholis Philip, 22, a student at the U.S. Navy Nuclear Power Training Command in Goose Creek, was arrested following a homicide investigation, according to a Berkeley County Sheriff's Office.
Officers with the Virginia Beach, Va. Police Department arrested Philip at about 10:24 p.m. on Oct. 1.
Earlier that day BCSO officers arrived at 302 Kershaw Drive in Sangaree to find the bodies of 26-year-old Ashley Kaney and her 8-year-old daughter Riley Burdick.
Riley's cause of death was asphyxiation by strangulation, according to an autopsy report released by Berkeley County Coroner Bill Salisbury on Oct. 2.
On Oct. 1 the VBPD warrant squad received information that a murder suspect with ties to Virginia Beach may possibly be in the oceanfront area of Virginia Beach, VBPD Public Affairs Officer Tonya Borman said.
"Our oceanfront community policing squad began working with the warrant fugitive unit canvassing the oceanfront and surrounding areas," Borman said Wednesday. "At about 10:24 p.m. one of our officers spotted the possible suspect vehicle in a parking lot.
"The individual was approached, identified and arrested without incident. It was also determined that the vehicle the suspect was driving had been stolen earlier in the evening from our town center area.
"He has been charged in Virginia Beach with the grand larceny of a stolen vehicle. He is currently being held in our correctional center without bond."
BCSO has charged Philip with two counts of murder and he is expected to be extradited to South Carolina. Philip has confessed to killing Kaney and her daughter, according to a BCSO statement.
It was determined the deaths were the result of an isolated case of domestic violence and did not pose a threat to the community, according to a BCSO statement.
Riley was a student at Sangaree Intermediate School. She had not been at school for two days and her mother could not be reached by school employees, who requested a safety check.
BCSO deputies received no response from the residence. They located an open window and entered. That's when they discovered the victims, according to a BCSO statement.
At least 10 deputies were on the scene into the night on Oct. 1. The street was blocked off by crime scene tape.
A neighbor of the victims, Paul Thomas, called the situation "unreal."
"Never seen anything like it," said Thomas, who added that he didn't realize anything was amiss until police showed up at the house.
Thomas said the victims had lived at the residence about a year.
"Senseless acts such as this have far-reaching effects on not only the families involved but our entire community," BCSO Sheriff Wayne DeWitt said in a statement. "Our thoughts and prayers go out to Ms. Kaney's family during this difficult time."
"This is an unspeakable tragedy," Berkeley County School District Superintendent Dr. Rodney Thompson said in a statement last week. "On behalf of the district, I offer my condolences, and our hearts and prayers are with Riley's and Ms. Kaney's loved ones and the entire Sangaree community."
The school implemented a crisis response plan for students and staff, BCSD Public Information Officer Susan Haire said.
Additional school counselors and district-level support staff were on hand at the school last week, assisting the community in processing the tragedy. Counseling and grief supports will continue to be available, according to Haire.
"Today and in the coming days, school personnel and district officials will be focused on fully supporting the school community and responding to its needs," Haire said.
Salisbury commended BCSO for putting together a team of investigators from nine agencies and thus making an arrest within hours. Those agencies are: BCSO, The U.S. Naval Criminal Investigative Service, the Virginia Technical College Police Department, The Blacksburg, Va. Police Department, VBPD, the SLED Child Facility Unit, the U.S. Marshals Service, the Berkeley County Coroner's Office and the 9th Judicial Circuit Solicitor's Office.
© 2016 The Berkeley Independent an Evening Post Industries company. All Rights Reserved.
Registration on or use of this site constitutes acceptance of our Terms of Service, Privacy Policy and Parental Consent Form.


text:
MIAMI - Miami-Dade County Mayor Carlos Gimenez had a lot on his plate this week, from a Local 10 investigation about hundreds of county-owned vehicles sitting idle to a controversy over a firefighter's Facebook posting.
When Gimenez was elected last year, he inherited a fleet of about 300 mothballed cars, vans and trucks purchased years ago by the previous administration.
"I understand that at one time, there was up to 1,500 vehicles in that garage, and that was the product of the commission. When I was on the commission, we reduced the size of the fleet and we ordered the size of the fleet to be reduced by 10 percent," Gimenez said.
The mayor said he is working to get those vehicles out into service.
"We'll continue to push out those vehicles and get them to where they need to be," Gimenez said.
Running Miami-Dade County government is a big, complex job. Gimenez has been at it for less than a year, but he has made it leaner and more efficient. This week, he eliminated 527 vacant jobs and nine department directors' jobs and got rid of benefits worth up to $10,000 for top county executives.
"We need to move forward. We need to tighten our belts, and we need to prove to the people of Miami-Dade County that we are part of this community. We will show that with action and not just words," Gimenez said.
A comment Miami-Dade Fire Rescue Capt. Brian Beckmann posted on Facebook about the Trayvon Martin case caused a firestorm and displeased the mayor.
"I and my co-workers could rewrite the book on whether our urban youths are victims of racist profiling or products of their failed, (expletive), ignorant, pathetic, welfare dependent excuses for parents," the post read.
"I thought they were reprehensible," Gimenez said of the comments.
"He's got First Amendment rights," Local 10's Michael Putney said.
"You have the right to make all these statements, and you're not going to go to jail. You won't be prosecuted, but in terms of your employment, there may be consequences to be paid for that," Gimenez said. We're looking to see, and I'm waiting for the fire department's report and their investigation. WE want to make sure that this is done right, and whatever it is that happens, that it sticks."
The mayor expects to get a recommendation soon and indicated there would be some punishment for Beckmann.
Copyright 2012 by Post Newsweek. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Top Definition
A woman whos pussy smells like tuna that has been left out in the sun for eight hours, or more. It occurs from the lack of hygene, and the fact that she has had at least five loads of jizz pumped in her daily, since sixth grade.
Kris MillSPAWN has the nastiest Salmon Snatch I have ever sniffed. 200 gallons of bleach and perfume could not get that to smell halfway decent. Has she ever though about cleaning it out every 3000 miles?? My god-what a nasty ho.
de J.R. Cahoon 28 Iunie 2004
Trending Now
Can you define these popular missing words?
A hoe who has a pussy with fiery red hair covering her crotch.
"Haha, Sally has a salmon snatch!"
"Smelly Sally has a salmon snatch!"
"Smelly Sally has a salmon snatch!"
de Gravox 09 August 2003


text: Disclaimer:This website is intended for the amusement of open-minded adults everywhere. All stories, although based on actual events, have been cleverly twisted by the warped mind of their creator. Any resemblance in these stories to any person, alive or dead is purely, coincidental even if they happen to have the exactly the same names, bodies and facial features as actual people


text:
Windows XP file unencrypt
Basically, I need to get file out of a windows encrypted file, but it wont ask me for the password, and i cant take it off or copy the file etc. Anyone know a tool to unencrypt it without the user files or w/e?
Re: Windows XP file unencrypt
Go look for one on http://www.packetstormsecurity.org they will maybe have a tool that will be able to do that.
|All times are GMT +5.5. The time now is 09:20.


text:
on September 17, 2012 - 12:01 AM
Several major retailers have made changes to their layaway programs heading into the holiday shopping season. Here's a rundown:
. Walmart - Reduced fee from $15 to $5. Starting program a month earlier, beginning on Sept. 16 and running through Dec. 14. Once the item is paid for, Walmart will give the consumer a $5 gift card. All items must cost at least $15. Total layaway purchase must be at least $50.
. Toys-R-Us - Layaway program is open now and won't charge a fee on items ordered by Oct. 31. After that, a $5 service fee will apply. Consumers must make a 20 percent down payment and pay 50 percent within 45 days. Item must be paid in full by Dec. 16.
Babies-R-Us has the same layaway policy.
. Kmart and Sears - No service fee on layaway purchases, but a $10 fee will apply if a layaway order is canceled. Requires an initial payment of $15 or 10 percent of the item's purchase price. Repayment period runs from eight to 12 weeks, with biweekly payments required. The Kmart program is running now. Sears is expected to launch its layaway promotion in October.
. T.J. Maxx and Marshall's - Offers a 30-day layaway program. Requires a down payment of 10 percent of the item's cost, or $10, plus a $5 service fee. Charges a $5 cancellation fee.
. Best Buy - Charges a 5 percent service fee. Requires upfront payment equal to 25 percent of the purchase price and subsequent payments every two weeks over an eight to 12 week repayment period. Item must cost at least $250. Not available at Western New York stores.


text:
Cruel, endearing, English darling. See snob.
JOmolA: "I am voting conservitive and am pro-establishment."
Aaragon: "You are such a Hatty."
Jomola: "Huh?"
Aaragon: "You are such a Hatty."
Jomola: "Huh?"
av Ho 9 september 2003
Trending Now
Can you define these popular missing words?
Top Definition
The most loyal friend you will ever have the fortune to meet. Hattys are very sensitive but LOVE to have a good time. Hattys are so trustworthy and will always keep your secrets. Sometimes they can give you away with out meaning to but because they are so nice you forgive them straight away. Hattys are so funny and very pretty and stunning. They aren't afraid to try something new and meet new people. Basically Hattys are the best friends you can get and will be an awesome friend for life.
Lucy: I'm upset.
Hatty: I loveyou bestfriends
Lucy: That makes it all better :P
Hatty: I loveyou bestfriends
Lucy: That makes it all better :P
av LittleRave 25 januari 2009
The act of doing something clumsy. Tends to be used with the word 'bloody' as the lead in.
av SempaiBC 16 mars 2011
Short for hat trick which is scoring three goals in a hockey game.
Dude, I got a hatty last night!!
av NCIX 1 februari 2007
a very very very pretty girl.
"oh that hatty, Shes very very pretty"
av Beej, aka Bj 5 april 2006
To give someone attitude. To be stubborn.
He was giving her hatties.
av tessamenaou 9 januari 2014
Hatty is a word that popped up in the East Melbourne ghetto in Victoria, Australia. It is short for 'Hat-Full-Of-Arseholes' which is a way of telling someone they are more than one arsehole (NOTE: If you don't live in Australia, London or any other place that uses the word arse, it is just our way of saying ass).
av Jacob Pantich 23 november 2004


text:
RICFest Homecoming Update: All outdoor activities planned for Oct. 1 have been moved indoors. Click here for details.
Rachel Filinson
|Craig-Lee Hall (CL) 461
(401) 456-8026
(401) 456-8732
Academic BackgroundProfessor Rachel Filinson graduated summa cum laude, Phi Beta Kappa, with a baccalaureate degree from the University of Illinois at Champaign-Urbana and received her M.Sc In Sociology at the University of Stirling (Scotland). She was employed as a Research Fellow at the Medical Research Council Institute of Medical Sociology in Aberdeen Scotland and simultaneously completed her Ph.D. in Sociology from the University of Aberdeen. Dr. Filinson was awarded an NIMH (National Institute of Mental Health) postdoctoral fellowship at the University of Missouri-Columbia and a Gerontological Society of American postdoctoral fellowship. While teaching at Purdue University in Indiana, she obtained funding for a new Gerontology Center. Since being hired at Rhode Island College, she has taught a wide array of courses that focus on gerontology, sociological theory, sociological methods, and service learning. On her last sabbatical, Dr. Filinson was a Visiting Senior Research Fellow at King's College London.
Dr. Filinson has published over 40 articles in scholarly journals (and a short story), edited a book entitled Elder Abuse: Practice and Policy and received numerous research grants from Rhode Island College to support her research, most recently on aged inmates. As coordinator of the Gerontology Center, she has organized a yearly conference on aging held at the College. She serves on the Board of Consulting Editors for the Journal of Elder Abuse & Neglect and on the board of United Methodist Elder Care.
Courses TaughtSOC 261 Fountain of Age
SOC 300 Classical Sociolog Theories
SOC 302 Social Research Methods I
SOC 315 Community
SOC 320 Law and the Elderly
SOC 404 Social Research Methods II
SOC 460 Senior Seminar in Sociology


text:
Sigma 120-400mm F4.5-5.6 DG APO OS HSM Nikon
Further readings for the Sigma 120-400mm F4.5-5.6 DG APO OS HSM Nikon
To provide photographers with a broader perspective about mobiles, lenses and cameras, here are links to articles, reviews, and analyses of photographic equipment produced by DxOMark, renown websites, magazines or blogs.
Aimed at professional studio and landscape photographers, the full-frame 36-Mpix D800E with its modified AA filter effectively increasing resolution over the standard D800 model is the closest 35mm full-frame camera yet to rival larger formats in rendering fine detail. If you're undecided over which of the two models to choose, we've analyzed the image quality of the Nikon D800E with over 100 different lenses to discover how well this groundbreaking camera performs.
Nikon has had an 80-400mm lens in its range for the past 13 years, which it has now updated. This is not just a bit of a tweak though; the new lens is sharper, better corrected for distortion and chromatic aberration and full of new technology. It is also heavier, bigger and more than 50% more expensive – so is it worth it?
The Sigma 120-400mm f/4.5-5.6 DG APO OS HSM is interesting for its longer focal lengths, equivalent to a 180-600mm on a Nikon DX body (and slightly more on a Canon APS-C). On a full-frame camera, it achieved a respectable DxOMark score of 15.8 though it dropped to just 11 on a Nikon D7000 (a slightly higher than on a D300s). Highpoints, apart from the extra reach, include consistent resolution across the image field (the Acutance map above shows the lens at 400mm), as well as good control of chromatic aberration, while the disadvantage of vignetting at maximum aperture is really only an issue for FF bodies. While not as pricey as some, $1,000 is still a sizeable figure given the performance at 400mm.
With the vagaries of photographing wildlife, the flexibility of a telephoto zoom would appear to be an attractive solution. However, image quality is often a compromise at the maximum aperture and longest focal length, typically the most crucial settings. We've pulled some lens data from our database and put together a round up of popular zoom lenses over the years (and made some comparisons with high performance primes). Read on to find out which models have the best image quality.
Added by coquelicot24 | January 07 , 2013
Sigma 120-400mm F4.5-5.6 DG APO OS HSM
Dommage que cet objectif ne soit toujours pas testé.
J'aimerais beaucoup le comparer avec ceux de la concurrence.
Added by sergioh | January 19 , 2012
lens reviews
How come that some lenses such as the Sigma 120-400mm, launched in 2008, still are not reviewed and do not appear in the lens rating chart while, in the same time, recently launched lenses are already reviewed?


text:
Top Definition
the ability to give insane head by a person who would consider themselves to be a penile connoisseur. An immeasurable force that represents fellatious skill.
Becky's jaw swag is on point, stellar, exemplary; you could say her head game is legendary.
JacroXP tərəfindən 24 Fevral 2011
Trending Now
Can you define these popular missing words?


text:
Klussendorf-MacKenzie awarded to New Yorker
Klussendorf-MacKenzie awarded to New Yorker
Brett Yerina, Johnstown, N.Y., won the coveted Klussendorf-MacKenzie Award presented during the 45th World Dairy Expo, in memory of Duncan McKenzie, 1961 Klussendorf winner.
View the video of the Klussendorf-MacKenzie Award and Klussendorf Trophy below:
Cow care and cow development — those are the passions of this year's MacKenzie Award winner. Over the years, Yerina has helped remodel four farms to better suit cow comfort and Holsteins in those barns, and the results have been impressive, as the herd he cares for has achieved Holstein BAA's (breed age averages) as high as 116.
Possessing a strong work ethic, the 21st MacKenzie Award winner began working on his family's farm before and after school as a 14-year-old. By 16, Yerina was helping manage the breeding and feeding program, handling flushes and working with crops. Today, he uses those skills as he works with the 50-cow herd he manages. In addition to managing an extensive embryo transfer program, Yerina handles 300 acres of hay, taking pride in making some of the best show hay possible at ElmVue Farm.
This winner's list of accomplishments includes working with 11 New York State Fair Grand Champions, 6 Eastern States Grand Champions, and 5 Syracuse Spring National Grand Champions. At World Dairy Expo, honors include developing two Supreme Champions, two Reserve Grand Champions, and several Honorable Mention Champions. Yerina also has helped develop six 96-point cows along with several 95-point individuals. What's more, the farm he manages has been honored with three herdsmanship awards and three Premier Exhibitor banners in the International Holstein Show at World Dairy Expo. Today, Yerina, the herd manager at ElmVue Farm, is working towards his goal of being awarded the Premier Breeder banner.
Above all, this year's winner definitely exemplifies all the principles of a Duncan MacKenzie recipient as to character, sportsmanship, ability, and endeavor. He has a passion to help others succeed, especially young people. Yerina is willing to share his knowledge by helping young dairy exhibitors pick up ways to enhance feeding programs and help improve show animals.


text:
Entertainment Photos
Oscars Red Carpet Photos: Who was hot and not at Academy Awards
Photo: John Shearer/John Shearer/Invision/AP
Jessica Chastain arrives at the 85th Academy Awards at the Dolby Theatre on Sunday Feb. 24, 2013, in Los Angeles. (Photo by John Shearer/Invision/AP)
To post a comment, log into your chosen social network and then add your comment below. Your comments are subject to our Terms of Service and the privacy policy and terms of service of your social network. If you do not want to comment with a social network, please consider writing a letter to the editor.


text:
Everyone counts down their favorites at the end of the year and we felt that we couldn't let the 2012 slip by without mentioning our favorite projects! It's even better when we share them with experts that bring their passion to the project!
Domino Pendants
One of the REAL hits of 2012! This project inspired Ninjas to grab their own alcohol inks and make a million domino pendants until the cows come home!
We love when one project spawns many Ninjas to go home and get to craftin'!
Sugar Skulls
After three years of making and sharing this sugar skull project, we're darn near experts! And so are you! Every time you do this project, you show better and better decorating skills! Even better, we're so thrilled to see return crafters come with their families and share this rad event!
Sew It All Felted Sweater Mittens
Sew It All Magazine is an outfit with some real deal craftin' ladies! And we had the honor of working with them and learning from them. I've broken out my mittens this winter and found them to be so darn warm and cozy!
Pinterest Tested Tie Dye Tights
Before our pal Amber hightailed it to Seattle, we got to play with this really fun tie dye tights project! If you love tights, this is the project for you to brighten up your collection and add a DIY splash to your wardrobe!
Canning with Helliemae's
We love Helliemae's! It's just that simple. And when Ellen opened the factory's doors to Ninjas to learn how to can chutney and make quick pickles, we fell in love all the more! The space was perfect for cooking up a storm and everyone left with tasty stuff.
Pasties with Ooh La La Burlesque
A little risque, a little naughty – hanging out with the rad ladies of Ooh La La Burlesque is a reminder that we can all use a little risque in our lives! Not only were these super talented burlesque mamas totally hilarious, but they were great teachers too!
Upcycled Jewelry with Colorado Bead Co.
We have several love affairs with local crafty businesses…and Anne at Colorado Bead Co. is definitely one of them! Anne let us take over the joint and provided us with all kinds of lovely beads and baubles and taught us to make some really cool upcycled necklaces with soda cans! Is there anything they can't do over there?
Felt Wreath
This project was a tedious and, at times, frustrating stuggle. But it turned out beautifully. And that's the reward! Beauty! After seeing the project on Dig This Chick, we realized we had to try it!
We hope that, in the new year, you'll try something new! We hope that in the new year, you'll join us for all kinds of crafty good times at Three Kings Tavern! We're planning and plotting and have some really cool partners lined up for 2013!
Happy New Year, Ninjas!


text:
Using the Container Database in Oracle Database 12c by Christopher Andrews
By Axel Timo Purr-Oracle on Nov 18, 2013
The first time I examined the Oracle Database 12c architecture, I wasn't quite sure what I thought about the Container Database (CDB). In the current release of the Oracle RDBMS, the administrator now has a choice of whether or not to employ a CDB.
Bundling Databases Inside One Container
In today's IT industry, consolidation is a common challenge. With potentially hundreds of databases to manage and maintain, an administrator will require a great deal of time and resources to upgrade and patch software. Why not consider deploying a container database to streamline this activity? By "bundling" several databases together inside one container, in the form of a pluggable database, we can save on overhead process resources and CPU time. Furthermore, we can reduce the human effort required for periodically patching and maintaining the software.
Minimizing Storage
Most IT professionals understand the concept of storage, as in solid state or non-rotating. Let's take one-to-many databases and "plug" them into ONE designated container database. We can minimize many redundant pieces that would otherwise require separate storage and architecture, as was the case in previous releases of the Oracle RDBMS. The data dictionary can be housed and shared in one CDB, with individual metadata content for each pluggable database. We also won't need as many background processes either, thus reducing the overhead cost of the CPU resource.
Improve Security Levels within Each Pluggable Database
We can now segregate the CDB-administrator role from that of the pluggable-database administrator as well, achieving improved security levels within each pluggable database and within the CDB. And if the administrator chooses to use the non-CDB architecture, everything is backwards compatible, too.
The bottom line: it's a good idea to at least consider using a CDB.
About the author:
Chris Andrews is a Canadian instructor of Oracle University who teaches the Server Technologies courses for both 11g and 12c. He has been with Oracle University since 1997 and started training customers back with Oracle 7. While now a Senior Principal Instructor with OU, Chris had an opportunity to work as a DBA for about 10 years before joining Oracle. His background and experiences as a DBA, Database Analyst and also a developer is occasionally shared with customers in the classroom. His skill set includes the Database Administration workshops, Backup & Recovery, Performance Tuning, RAC, Dataguard, ASM, Clusterware and also Exadata and Database Machine administration workshop. While not teaching, Chris enjoys aviation and flying gliders, underwater photography and tennis.


text:
Just where did the "jerk" come from in Jamaican jerk?
After an Isle of Palms reader requested a recipe for the island's famous jerk chicken, it sent me on a quest to find out.
Most accounts trace jerk to the Spanish word charqui, a term for jerked or dried meat. But in the Caribbean, jerk refers to both a spice mixture and a cooking technique.
Many food historians be- lieve the jerk tradition was started by West African Cormantee slaves who escaped the Spanish and British in the mid-1600s and found refuge in the island's mountains, mixing with the resident Indians.
The two core ingredients are allspice, called pimento in Jamaica; and Scotch bonnet peppers, which look like shrunken heads and are about as fiery as a habanero, although somewhat fruitier.
Other common ingredients include cloves, cinnamon, scallions, nutmeg, thyme, garlic and salt.
The jerk spice mix can be applied to the meat as a dry rub or used in a wet marinade. Then the meat is cooked over a fire (pimento wood is traditional). The heat burnishes the spices on the surface into a mahogany-colored crust, a barbecue lover's dream.
In Jamaica, the cooking has evolved over time from pits to halved and hinged steel drums, a common sight today along the roadsides. Charcoal is the fuel of choice these days.
Thanks to Ethel Inabinett of Ravenel for sending a recipe, which called for a store-bought spice mix. But to better understand jerk from start to finish, I turned to "The Grilling Book: The Definitive Guide From Bon Appetit" (Andrews McMeel, 2013).
As always, be very careful when working with hot peppers. You are advised to wear food-handling gloves.
Jerk Chicken
4 servings
1 (4-pound) chicken, cut into 8 pieces
1 medium red onion, chopped
12 garlic cloves
10 Scotch bonnet or 15 small habanero chilies, stemmed and seeded
8 scallions, white and pale green parts only, chopped
1 (3-inch) piece ginger, peeled and sliced
2 tablespoons chopped fresh thyme
11/2 tablespoons ground cinnamon
11/2 tablespoons whole allspice
1 tablespoon kosher salt
1 tablespoon powdered adobo seasoning
1/2 teaspoon Maggi Liquid Seasoning
Vegetable oil, for brushing
Pierce chicken all over with the tip of a small knife; transfer to a large bowl. Puree onion, next 10 ingredients and 3/4 cup water in a blender until smooth. Reserve 1 cup for dipping sauce if desired. Pour remaining marinade over chicken; massage into chicken. Cover; chill for at least 1 day and up to 2 days.
Let chicken sit at room temperature for 1 hour before cooking. Build a medium-low fire in a charcoal grill, or heat a gas grill to medium. Brush grill grate with oil. Place chicken on grill, skin side up. Cover grill and cook, turning occasionally, until skin is crisp and nicely charred and an instant-read thermometer inserted into the thickest parts of the chicken registers 165 degrees, 30 to 45 minutes.
Transfer chicken to a platter and tent loosely with foil; let stand for 10 minutes. Serve with reserved marinade as a sauce, if desired.
Sharon Cook of Charleston passes along a recipe from Simply Recipes online.
Jerk Chicken
Serves 6 to 8
1/2 cup malt vinegar (or white vinegar)
2 tablespoons dark rum
2 Scotch bonnet peppers (or habaneros), with seeds, chopped
1 red onion, chopped
4 green onion tops, chopped
1 tablespoon dried thyme or 2 tablespoons fresh thyme leaves, chopped
2 tablespoons olive oil
2 teaspoons salt
2 teaspoons freshly ground black pepper
4 teaspoons ground allspice
4 teaspoons ground cinnamon
4 teaspoons ground nutmeg
4 teaspoons ground ginger
2 teaspoons molasses
1 (5 or 6 pound) roasting chicken, cut in half, lengthwise
1/2 cup lime juice
Salt and pepper
Safety note: Wear protective gloves while handling the chilies and the jerk paste.
Put vinegar, rum, hot peppers, onion, green onion tops, thyme, olive oil, salt, pepper, allspice, cinnamon, nutmeg, ginger and molasses into a blender. Pulse until mostly smooth.
Place chicken in a large freezer bag, or in a large roasting pan or baking dish. Pour lime juice over the chicken and coat well. Add the jerk paste to the chicken pieces and coat well. Seal the bag or cover the chicken in the pan with plastic wrap. Refrigerate overnight.
When you are ready to cook the chicken, remove chicken from the marinade bag or pan. Put the remaining marinade into a small saucepan. Bring to a boil, reduce heat and simmer for 10 minutes. Set aside to use as a basting sauce for the chicken. If you want, you can reserve a little of the marinade (once boiled for 10 minutes since it has been in contact with raw chicken) to serve with the chicken or to mix with some ketchup and a dash of soy sauce for a serving sauce.
Preheat grill to medium high. Sprinkle chicken halves with salt and pepper. Place chicken halves, skin side down on the grill grates. Cover. Cook for approximately 1 hour, keeping the internal grill temperature between 350 and 400 degrees, turning the chickens occasionally and basting with marinade, until the chicken halves are cooked through. The chicken is done when the juices run clear (not pink) when a knife tip is inserted into both the chicken breast and thigh, about 165-170 degrees. Transfer chicken to platter. Tent loosely with foil to keep warm and let stand 15 minutes.
Cut chicken into pieces. Suggestion: Serve with black beans and rice.
We also found a recipe in "Weber's Time to Grill" (2011) by Jamie Purviance that is less traditional — it uses pork tenderloin — and is served with a bright summer salsa.
Jerk Pork Medallions With Grilled Corn and Cucumber Salsa
Serves 4
For the salsa:
2 ears fresh corn, husked
Extra-virgin olive oil
1/2 English cucumber, cut into medium dice (about 11/2 cups)
1/2 medium red bell pepper, finely diced
1/2 cup crumbled feta cheese
2 tablespoons cider vinegar
2 tablespoons finely chopped fresh oregano leaves
1/2 teaspoon kosher salt
1/4 teaspoon ground cayenne pepper
1/4 teaspoon ground black pepper
For the jerk paste:
3 tablespoons extra-virgin olive oil
2 tablespoons soy sauce
1 tablespoon onion powder
1 tablespoon packed brown sugar
2 teaspoons dried thyme
2 teaspoons ground allspice
1 teaspoon ground cayenne pepper
1 teaspoon ground black pepper
1 teaspoon garlic powder
1/2 teaspoon ground nutmeg
1/2 teaspoon ground cinnamon
2 pork tenderloins, each 3/4 to 1 pound, trimmed of excess fat and silver skin
Prepare the grill for direct cooking over medium heat (350-450 degrees).
Lightly brush the ears of corn with oil. Brush the cooking grates clean.
Grill the corn over direct medium heat, with the lid closed as much as possible, until the corn is browned in spots and tender, 10 to 15 minutes, turning occasionally.
Remove from the grill and, when cool enough to handle, cut the corn kernels off the cobs into a medium bowl. Add the remaining salsa ingredients to the bowl, including 2 tablespoons oil, and set aside until ready to use.
In a small bowl mix the paste ingredients.
Cut off the thin, tapered end from each tenderloin and reserve for another use, or grill along with the medallions. Cut each tenderloin crosswise into six equal pieces, each about 11/2 inches thick.
Brush the paste all over the medallions, cover with plastic wrap and let stand at room temperature for 15 to 30 minutes before grilling.
Grill the medallions over direct medium heat with the lid closed as much as possible, until the outsides are evenly seared and the centers are barely pink, 4 to 6 minutes, turning once.
Remove from the grill and let rest for 3 to 5 minutes. Serve warm with the salsa.
Who's got the recipe?
A coworker would like to know how to make Southern-style lima beans.
Looking for a recipe or have one to share? Reach Features Editor Teresa Taylor at firstname.lastname@example.com or 937-4886.


text:
Bellwood-Antis' defensive unit didn't need to be spectacular in Saturday night's District 6-A championship game in which the Blue Devils rolled to a 54-3 rout over Bishop McCort on Mansion Park's snow-specked field.
But on a night when McCort was penalized a dozen times for nearly 100 yards and committed five turnovers, the Blue Devils' defensive unit turned in a very solid performance.
McCort, which finished a 9-4 season, had averaged 38 points per game in its last four outings, including respective 32- and 45-point performances against Penns Manor in the quarterfinal round of the playoffs and 45 against Northern Cambria in last week's semifinal round.
But a Bellwood defense which has allowed an average of less than eight points per game in its last seven outings permitted McCort only a 30-yard, first-quarter field goal by senior Jordan Spangler Saturday.
"It was a great effort the whole way around,'' Bellwood-Antis defensive coordinator Bill Crowell said. "We tackled well, we adjusted to their formations, and the kids on the unit as a whole played very well.''
Bellwood-Antis senior Seth Worthing, who intercepted a pair of passes on defense, also broke up a third-down pass in the end zone on McCort's only scoring drive of the night, forcing the Crushers to settle for a field goal.
"Knocking down what would have been a touchdown pass was a big play for us there,'' veteran Bellwood-Antis coach John Hayes said. "After we kept them to a field goal, things began to separate from that point.''
Worthing, who also recovered a fumble, is a two-year starter at safety. His twin brother, Cameron, is a two-year starter at cornerback for Bellwood, which also features two-year senior starters Tyler Campbell at inside linebacker, Keith Shawley at defensive tackle, and Ian O'Shea at linebacker, as well as another two-year starting cornerback in junior Casey Gray.
"Our defense has been improving as the year has gone on,'' Seth Worthing said. "We've really stepped it up, especially in the secondary.''
Seth Worthing was quick to credit the play of Bellwood's defensive front, which includes Shawley and juniors Nick Torsell, Ethan Hunter and Kyler Maceno.
"Our line was great at flushing the run, and forcing their quarterback to throw,'' said Worthing, who had what would have been a 92-yard interception return for a touchdown nullified when Bellwood was called for a block in the back in the second quarter. "That let me come up and make a couple picks.''
The Blue Devils' defensive unit practiced well all week, according to Campbell.
"It all starts in practice, and we worked our butts off in practice this week,'' he said. "Tonight, there were 11 guys to the ball every time. Allowing [just] three points in the district championship game is unbelievable.''
That kind of cohesive effort allowed Bellwood to erase the gloomy memories of last year's loss to Penns Manor in the District 6-A championship game and move on to the first round of the state playoffs next Friday night against Delone Catholic at Mansion Park.
"Tonight definitely makes up for everything that happened last year,'' O'Shea, a 6-2, 190-pound linebacker, said. "We've put in a lot of hard work this year.''


text:
Top Definition
A soft drink cup from McDonald's used as a receptacle or cuspidor into which girls who do not swallow,spit cum.
When my date did not discard her cup after she finished her Coke,I had high hopes she was saving it as a McSpittoon.
viết bởi wolfbait51 30 Tháng tư, 2011
Trending Now
Can you define these popular missing words?


text:
Dashawn Trevell Brown, 20, of Groves Street in Walterboro, is wanted on one count of murder and two counts of attempted murder, sheriff's deputies said.
On Wednesday, sheriff's deputies arrested Ikeal Emar Dacus, 23, of Bryant Road in Reevesville, on the same charges.
The arrest wasn't Dacus' first run-in with law enforcement.
Dacus was jailed in November 2008 accused of manufacturing and distributing cocaine. He pleaded guilty to a lesser possession charge and was released with time served, Dorchester County court records show.
Dacus had a run-in with St. George police again on July 3 when he and a friend beat and threatened to shoot a man in an armed robbery at the Country Hearth hotel, an incident report states.
The man told police he grew up with his attackers and chose not to press charges against them as a result.
Two weeks later, Sierra Denise Truesdale, a Trident Tech student, was fatally struck when shots were fired into a crowd outside Starlight Lounge, a nightclub in the Hudson Town community on the outskirts of St. George.
Truesdale was celebrating her 23rd birthday at the club when she was killed. She bled out in the back seat of a car as friends attempted to get her to a local hospital, deputies said.
D'Anna Deal, 23, of Walterboro, and Bryan Williams, 29, of St. George, also were wounded in the shooting.
Lt. Tony Phinney said a fight between Dacus and a Walterboro street gang known as the Get Money Cowboys prompted the shootout. Brown identifies himself as a member of that gang, Phinney said.
At least 17 shots were exchanged in the gunfire, arrest affidavits for Dacus state. Witness statements identified Dacus as one of the gunmen.
The shooting remains under investigation and more arrests are likely, Phinney said.
Anyone with information on Brown can call the Dorchester County Sheriff's Office at 873-5111 Crime Stoppers at 554-1111.
Reach Christina Elmore at 937-5908 or at Twitter.com/celmorePC.


text:
Graubünden has every colour: Red for the Rhätische Bahn railway, yellow for the postal buses, blue for its 615 lakes and the skies above 150 valleys, green for forests and pastures, golden brown for larch trees in autumn, grey for castles and rocks, and white for snow and ice.
Choose red to take the Rhätische Bahn to Klosters, Davos, Arosa, St. Moritz, the Surselva region, the Engadine and Valposchiavo. Choose yellow and see Savognin and the Müstair valley, Lenzerheide, and the Mesolcina and Bregaglia valleys by postal bus. Pick grey for climbing a sheer rock face, and white for storming peaks and traversing glaciers. Or simply sit down on a patch of green and enjoy azure skies above.
Snap on your skis and take a paraglider taxi through the air, or join high altitude ski tours that bring you closer to the heavens. Discover the meaning of silence when you float across snowed-in valleys in a hot-air balloon, whilst taking in the many faces of Mother Nature across the diverse landscape. Have a professional take you down the St. Moritz Olympic bobsled run. Toboggan from Preda to Bergün or brave a glacier downhill run on the Diavolezza... Who doesn't dream of adventures like these?
Whether skiing, snowboarding, cross-country skiing or taking a ride on a horse-drawn sleigh, everything is possible in Graubünden's resorts with their near-guaranteed perfect snow conditions. How about a gourmet dinner far away from the crowds? Learn about the rich culture of Switzerland's eastern-most holiday region and its capital Chur, the oldest town in the country. Or why not simply relax in a traditional spa? Try Telemark skiing, parabol skiing or snow golf – putting a red ball on a white «green». In Graubünden, all of this is possible – and much more.