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LC-MS Gains Favor Due To the...
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Avastin maker Genentech argues that PFS should be the primary endpoint, while FDA believes that the drug's failure to significantly improve OS is the key issue. [James Steidl - Fotolia.com]
FDA's success in removing Avastin's metastatic breast cancer (MBC) indication has sparked a longstanding debate in drug development circles: What is the best proof that a drug works and should be approved? A panel discussion held November 29 in Cambridge, MA, debated whether the primary endpoint for regulatory sanction should remain overall survival (OS) or if it should change to progression-free survival (PFS)?
In Avastin's case, a divided FDA initially gave the drug accelerated approval, in combination with paclitaxel, for MBC in 2008. The decision was based on a clinical study showing a 5.5-month increase in PFS to 11.3 months. Starting last year, though, FDA's Center for Drug Evaluation and Research (CDER) began recommending that the MBC indication for Avastin be withdrawn.
CDER pointed to new studies, one of which showed a difference in overall survival for patients with MBC of less than two months—from 24.8 months to 26.5 months. "The addition of Avastin to paclitaxel resulted in an improvement in PFS with no significant improvement in OS," CDER declared in an April 7 filing.
Avastin maker Genentech and parent Roche argued that PFS should be the primary endpoint, because it could be objectively measured and because the EU recognized it as an endpoint in oncology clinical studies. FDA countered that the primary endpoint should instead be overall survival, while PFS should continue as a surrogate endpoint of clinical benefit. Additionally, FDA said Avastin's PFS improvement was not worth the risk of associated side effects like severe high blood pressure, hemorrhaging, heart attack or failure, and the development of perforations in the nose, stomach, and intestines.
Roche still hopes to reinstate the indication for previously untreated MBC through a Phase III study. The study will in part examine a potential biomarker that the company says may help identify patients likely to derive substantial benefit from the drug.
During the discussion held on November 29, called "Surrogates or Survival: A Discussion on Endpoints in Multiple Myeloma Clinical Trials," moderator Anne Quinn Young recalled how cancer treatment has changed over the past 10 years. A decade ago, she said, FDA was willing to accept PFS as an endpoint because so many cancers had a poor prognosis that to expect OS improvement wasn't relevant.
That has changed as new cancer treatments have led to patients surviving longer and in better shape, continued Quinn Young, vp of strategic alliances for the Multiple Myeloma Research Foundation (MMRF). "Patients and clinicians have raised the bar," she said. "They're not putting up with high toxicities any more.
"There's kind of a shift toward the view that an advantage in progression-free survival is one thing, but now we have agents that are demonstrating an advantage in overall survival. So perhaps we should start looking at the way patients are treated in a little bit different way."
Both PFS and OS are appropriate endpoints to define clinical benefits for patients with metastatic cancer, Axel Hoos, M.D., Ph.D., co-chairman of the Cancer Research Institute Cancer Immunotherapy Consortium (CIC), told GEN: "Ultimately, to define patient benefit, the key question is how great is the benefit of either of the two endpoints to say if it's clinically meaningful or not."
Additionally, Dr. Hoos noted, "it depends on some of the agents that are being investigated, so the type of therapy and then what endpoint is more useful." For example, "if immunotherapies are less prone to deliver conventional responses, and this is an endpoint, then that is only incompletely reflecting the clinical benefit that an immunotherapy can provide," Dr. Hoos added. "It doesn't mean that PFS is not a useful endpoint. It still is. But it doesn't tell the whole story."
Dr. Hoos also serves as medical lead in immunology/oncology at Bristol-Myers Squibb (BMS). "For the immunotherapies that we've investigated so far," he commented, "we believe survival is the better endpoint because it encompasses the full spectrum of clinical benefit."
Dr. Hoos noted that two cancer therapies approved in recent years have shown clear survival benefits—Dendreon's Provenge vaccine and BMS' Yervoy (ipilimumab) antibody for melanoma: "For Provenge, you have no PFS improvement at all. For ipilimumab, there is a PFS improvement, but it is smaller than the survival improvement. So in both cases, I would say, it's very clear that survival is the right endpoint."
The fact that both endpoints have their merits under varied conditions suggests that their value to patients may indeed, as the panelists concurred, depend on the individual. Noopur Raje, M.D., director of the multiple myeloma program at Massachusetts General Hospital and one of the panelists, said decisions on treatments and their endpoints need to be tailored to individual patients based on factors that include age, mobility, and income.
"Ultimately, of course, the absolute endpoint should be: Our patients should live longer, but not just longer; they should live better with myeloma." As Dr. Raje correctly noted in relation to multiple myeloma but which applies to other forms of cancer, there's a lot of heterogeneity within diseases—heterogeneity that researchers are only now beginning to take a serious look at.
"The way we treat myeloma today is one size fits all. And that's not true at all," Dr. Raje said. "Absolutely, I think the next step forward is to better re-stratify, better understand the genetics of patients' myeloma, and to do targeted treatment. And that's the level of understanding we need to get to."
Alex Philippidis is senior news editor at Genetic Engineering & Biotechnology News.
Alex Philippidis is senior news editor at Genetic Engineering & Biotechnology News.
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Spring Fiesta coming to Sierra-at-Tahoe
It all starts with the college shred fest on Saturday, March 23. College students can take advantage of $40 lift tickets just by showing their college ID and enjoy a party in West Bowl at the Baja Grill. The party will include volleyball, horseshoes, contests, giveaways, dance-offs and more. Additionally, Sierra Resort will be celebrating spring break with $57 tickets during college weeks March 18-22, 25-29, and April 1-5.
Don't miss the Salsa Showdown on Sunday, March 24. This sixth annual event will take place at the Baja Grill in West Bowl. The first 30 homemade salsa entries will compete for a Sierra Resort season pass for next season. There will also be a taco eating contest and a live mariachi band.
Youth softball sign ups underway
ASA, a youth spring softball league, will be holding six sign up days, three at Kahle Community Center and three at South Tahoe Ice Arena. The first sign up day is Monday from 6 to 7:30 p.m. at Kahle. The cost is $95 per player. For families with two or more players the cost will be $85 per player. Players receive uniform, sweatshirt, medals for participation, trophies for champions, and a team and individual picture. New players need to provide a birth certificate. Returners do not. The season runs May through mid June.
Homewood to host rail jam Saturday
Homewood Mountain Resort will host the inaugural Homewood Rail Jam on Saturday, March 16. The event will feature a live disc jockey, a spectator-friendly venue and big prizes from some of the industry's top brands, plus cash awards for top contestants. Open to men and women ages 12 years and older, the event will take place on a specially-built rail collection installed in Homewood's Happy Terrain Park above the North Lodge – one of Homewood's four terrain parks. The convenient location offers spectators the perfect venue to cheer on their favorite competitors. The open jam format allows skiers and riders to squeeze in as many runs as they can, and judges will award points for style and technique. Prizes will be awarded for the top three in each division, and Homewood will also recognize those with the "Best Crash" and "Audience Favorite." Proceeds from the $10 registration fee will benefit the local mentoring programs of Big Brothers Big Sisters of Nevada County and North Lake Tahoe. Registration opens at 11 a.m. and the competition starts at 1 p.m. For full details, visit www.skihomewood.com/railjam.
Donner Ski Ranch to host Snowskate contest
The 5th Annual Minus 7 Melee Snowskate contest is hitting the slopes of Donner Ski Ranch on Saturday, March 16, from 10 a.m. to 4 p.m. Witness top riders in this burgeoning sport as they put it all on the line for cash, prizes and best of all: bragging rights. The action begins with skatercross races that pit four riders at a time through a tight course of turns and drops that will determine who can lay the speed down and hold the line. Next, a custom-built snowskate terrain park welcomes the riders to the slopestyle action, complete with hits, rails and boxes. The contest ends with a winner-takes-all downhill race. Kurt Zapata's Minus 7 Snow Skates is a locally-owned company that has supported the North Tahoe snowskate community from the beginning. For more information contact firstname.lastname@example.com or check out the Minus 7 Snowskates facebook page.
Sugar Rush coming to Royal Gorge
Royal Gorge Cross Country Resort will host the Sugar Rush Nordic ski race Sunday, March 17, a 16-kilometer competition on a fast course that begins and ends in the Van Norden Meadow. The Sugar Rush race is the first competition at Royal Gorge since Sugar Bowl Resort assumed management of the cross-country resort, and is a preview of the resort's plans to bring back the long-standing "Gold Rush" Nordic race next year. Sugar Rush racers start the race on the flat terrain of Van Norden Meadow, climb through rolling terrain to the Village at Sugar Bowl, and descend to a flat finish back at Van Norden Meadow. Recent snow has allowed Royal Gorge groomers to widen the trails throughout the race course, which will leave ample room for racers to pass. The race begins at 10 a.m. Registration costs $35 and is available by phone at 530-426-3871, through royalgorge.com or in person at the start at Van Norden Meadow. For more information, visit www.royalgorge.com.
Compiled by staff

subset: commoncrawl


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"One took me to the darkness,
one led me to the light.
One showed me how to love,
one taught me how to fight.
I guess you could say I am an overachiever.
And I owe a debt of gratitude
to pimps and preachers."
- From the Paul Thorn song
"Pimps and Preachers"
Like that other singer from Tupelo, Miss., church is where it all started for Paul Thorn.
"We went to black and white churches," Thorn said. A thick Southern drawl comes across the telephone, its pitch a couple of octaves higher than his singing voice.
"The music in the black churches was rhythm-and-blues oriented and the music in the white churches was more country western. So I think how I was molded as a musician was by growing up in the churches."
A son of a Pentecostal minister, Thorn began singing in front of people when he was just 3 years old. Speaking in tongues came later. And before he entered the same profession as his hometown icon Elvis Presley, he was a fighter.
"Why do we argue? Why do we fight?
Everybody thinks God's on their side.
Just count to 10 before you throw a stone.
Whatever you believe, you might be wrong."
- "You Might Be Wrong"
Thorn says he got his "mojo" from his father and uncle, who both encouraged an indefatigable spirit for any endeavor. His two mentors' livelihoods were a contrast, but Thorn came to the conclusion that there was good and bad in everyone.
The youngster won 27 out of his 30 amateur boxing matches, good enough to turn pro. He aspired to win a world title when the middleweight was pitted against one of the sport's all-time greats, Roberto "Hands of Stone" Duran, who won by technical knockout when the young challenger was too bloody to continue. Thorn fought a few more times and with a 14-4 record he left the ring to step upon a stage.
"I gave it my all," he said. "I just didn't have the natural ability to be a champion."
"She cooked me biscuits and collard greens.
She even told me, I was her king.
But then she whispered, I'm going out.
I think I know what that's about."
"I can't sleep, I'm such a wreck.
She's got a hickey on her neck.
I'm getting worried I am gonna buy
some Jezebel a pesticide."
- "Weeds In My Roses"
Gardening is the passion of Thorn's friend, Elvin Bishop, a Tulsa, Okla., native who has lived the second half of his life in Northern California. Perhaps its because of their roots that both Thorn and Bishop's music is often been described as southern rock.
During the heyday of Lynyrd Skynyrd and the Allman Brothers, southern rock dominated radio. Bishop wrote the hit song "Fooled Around and Fell In Love," and became a nationwide star.
Thorn, self-deprecatingly titled one of his albums "Still No Hits." But he's successful enough to perform all across the country, and when he comes through California he visits Bishop, and the two chat on a porch, where the host with an acoustic guitar played his tune "What the Hell is Going On." Thorn was so moved he covered the song and used it for the title of his latest record. The entire album is comprised of songs others have written, an aberration in the career of a prolific songwriter with eight studio albums. He's a compelling storyteller with homespun wisdom and humor who carries a notepad in his back pocket.
"The hard part is getting an idea," he said.
"Well I bought me a shirt at a yard sale
just like the one Garth Brooks wears.
I'm gonna wash and blow dry my mullet
and put on some clean underwear.
Pretty soon I'm gonna make it in Nashville
but for now it will have to wait.
Because right now I'm singing karaoke
in a restaurant while everybody eats a catfish plate."
- "Honky Tonk Neanderthal"
Thorn's music can fall in different categories: country, Americana, southern rock, blues. When he's on stage, however, he transcends any musical definition. Sure, he sings songs, but he also has a conversation and rapport with the audience.
"I've got old Dean Martin shows on DVD and I study those," he said. "When I was a kid I really didn't understand the brilliance of Dean Martin but now that I am grown, I study those videos and I pick up tips from him and other people because those old-school entertainers are just fantastic and the world doesn't need to let that type of entertainment die. It will work in front of any audience. It will work in front of a blues audience or a country western audience. It's just entertainment. I consider myself an entertainer more than anything."


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|First Direct Imaging of Swollen Microgel Particles
Microgels are soft-material particles consisting of cross-linked polymer networks, 100 nm to 1 μm in diameter, dispersed in a continuous medium such as water. A useful feature of certain types of microgel particles is that they can swell or shrink with changes in external triggers such as pH and temperature. Thus microgel particles can act like "nanosponges" and offer many potential applications in medicine, environmental science, and industry. Because microgels are usually employed in their swollen state, in situ characterization of these particles under such conditions is desirable for understanding their behavior. However, optical microscopy is inadequate to this task, being limited in resolution and by the very small difference in refractive index (i.e., contrast) between the swollen particles and the continuous phase. Now, an international team of researchers from the U.S. and U.K. have obtained the first images of swollen microgel particles directly in aqueous solution using x-ray microscopy at the ALS, which, together with spectroscopic determination of their chemical state, provides insight into the underlying swelling mechanism.
The special properties of microgel particles are due to the presence of covalent bonds between different parts of the polymer chains (i.e., "cross-linking") and the presence of active functional groups. They allow, for example, the polymer network to retain water and the microgels to exhibit interesting physical properties not seen with common polymer latex microspheres. In this study, the researchers investigated lightly cross-linked poly(4-vinylpyridine)-silica (P4VP-SiO2) nanocomposite microgel particles synthesized in aqueous solution. Below a critical pH value of around 3.7, the 4-vinylpyridine residues become fully protonated, leading to significant swelling. The hydrodynamic diameter measured by dynamic light scattering (DLS) changes from around 230 nm (pH 8.8) to 620 nm (pH 3), which indicates a volumetric swelling factor of more than an order of magnitude.
The x-ray microscopy characterization was carried out using the polymer scanning transmission x-ray microscopy (polymer-STXM) endstation at ALS Beamline 5.3.2. STXM provides both high spatial resolution imaging (better than 50 nm) with zone-plate focusing and good chemical sensitivity based on near-edge x-ray fine structure (NEXAFS) spectroscopy. Using the "water window" photon energy region between the carbon and oxygen 1s absorption, the microgel particles can be imaged in their swollen state directly in aqueous solution through the use of a so-called wet cell, which consists of two thin silicon nitride membranes that are sealed together.
The investigation focused on nitrogen 1s rather than carbon 1s NEXAFS for both STXM imaging and spectroscopic studies. This was partly owing to the ease of handling multicomponent complex samples in wet cells at this particular energy but also because the pH-sensitive chemical environment of the nitrogen atom is of particular interest in this system. The researchers first obtained the nitrogen 1s NEXAFS spectra for both neutral and protonated linear P4VP homopolymer. These well-resolved lowest-photon-energy peaks served as excellent markers for the protonated and neutral states of the pyridine rings, and the corresponding two photon energies provided sufficient chemical contrast between the microgel particles at high and low pH (neutral form: 398.9 eV, protonated form: 400.4 eV).
The STXM images showed the well-dispersed swollen microgel particles at low pH in contrast to the nonswollen particles at high pH. The average size data of each particle was in good agreement with the DLS data. Subsequently, nitrogen 1s NEXAFS spectra were acquired from the individual hydrated microgel particles to estimate their degree of protonation. The resulting spectra at both low and high pH have sharp peaks at the same photon energies as the corresponding reference spectra. From this result, the researchers concluded that the nitrogen atoms of these P4VP-based cationic microgel particles are completely protonated at low pH. The researchers expect that these results will lead to the systematic investigation of a range of microgel particles in the future.
Research conducted by T. Araki and H. Ade (North Carolina State University) and S. Fujii and S.P. Armes (University of Sheffield, U.K.).
Research funding: U.S. Department of Energy, Office of Basic Energy Sciences (BES); Royal Society/Wolfson Research Merit Award; and Engineering and Physical Sciences Research Council (EPSRC). Operation of the ALS is supported by BES.
Publication about this research: S. Fujii, S.P. Armes, T. Araki, and H. Ade, "Direct imaging and spectroscopic characterization of stimulus-responsive microgels," J. Am. Chem. Soc. 127, 16808 (2005).


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Top Definition
1) A large gun used to blow things up.
2) A rather potent cocktail-shot consisting of Sambuca and Rum.
2) A rather potent cocktail-shot consisting of Sambuca and Rum.
1) Shit! They're shooting at us with Howitzers!
2) I'm going to the bar for a Howitzer.
2) I'm going to the bar for a Howitzer.
od uživatele Snake 18. červenec 2004
Trending Now
Can you define these popular missing words?
A Howitzer is a powerful, automatic loading artillery cannon. The current artillery in the USA military is the M109 Howitzer. It is mobile and can fire many, high explosive rounds at far away targets. Howitzers are generally used for support or to soften up an area before said area is invaded.
Before the massive assault on Fallujah during Operation Iraqi Freedom, starting in November of 2004, Howitzers fired many rounds at strategic targets to soften up the area, then fired during the invasion when soldiers needed support.
od uživatele TI 13. listopad 2004
The common occurrence while defecating when a loud powerful fart proceeds a fast moving shit bullet that chips the bowl
He drunkenly fell off the crapper and howitzered through the stall wall where the shit shrapnel got lodged in the occupant's leg
od uživatele joshster 10. srpen 2007
Referring to a really fat girl. Comes from the saying "Bringin in the big guns"
"That club would be nice if there weren't so many howitzers in there"
od uživatele Skillz925 15. červen 2009
A robotic cannon used in desert storm. It is a very devastating weapon and only takes 2 men to fire. It is much more effective than the world war 2 artillery cannons.
The Howitzer was invented by the Germans.
od uživatele The Man 16. říjen 2003


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Quality Education in the Benedictine Tradition
January 30, 2013
An engineering competition for area high school students, co-sponsored by Carbone's Restaurant of Crabtree and the Herbert W. Boyer School of Natural Sciences, Mathematics and Computing at Saint Vincent College, will be held at 6 p.m. Monday, March 4 in the Fred M. Rogers Center. The public is welcome to watch as miniature bridges made out of uncooked pasta are loaded with increasing weights until they collapse. Forty teams from nine Westmoreland County high schools will participate in this year's contest including Derry Area, Greensburg Central Catholic, Greensburg Salem, Hempfield Area, Jeannette, Greater Latrobe, Norwin, Penn Trafford and Yough. "We are happy to welcome the seventh annual pasta bridge building competition to the Rogers Center where this interesting engineering contest will display the students' work before the testing begins," commented Dr. John Smetanka, vice president for academic affairs, academic dean and assistant professor of physics at Saint Vincent College. "Saint Vincent provides opportunities for students to pursue engineering studies through a 3/2 cooperative program with Penn State, University of Pittsburgh and Catholic University. We also offer undergraduate degrees in the natural sciences, physics and physics education." Participants are provided with two pounds of spaghetti noodles, ten pieces of lasagna noodles and a hot glue gun which they use to build model bridges they designed in their respective school classrooms over a two-month period. Students will carefully transport their constructions to Saint Vincent for display in the Atrium for one hour prior to the competition. During the competition, weights are added to the bridges until they fail to support. The bridge that sustains the highest amount of weight before collapsing is the winner. Judges for the competition will be Mr. Matt Burns of Gibson-Thomas Engineering, Laura Volle of Michael Baker Corporation, and Dr. Stephen Jodis and Dr. Paul Follansbee of Saint Vincent College. The competition is designed to increase high school students' awareness about the role engineering plays in their lives and the career opportunities in the field and to provide an opportunity for students to collaborate on the design and construction.


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Ball State Sports Link: Kenneth Lee (Football)
Get to know Ball State Athletes from every sport with our weekly feature, SL - IN Focus. Each week we introduce you to another Ball State Student-Athlete and his or her story.
This week meet football's Kenneth Lee as the Cardinals wrap the regular season at Miami. Produced by Pat Boylan and Palmer Durr.
Join The SL Nation:
Connect with over 7,000 other fans and get daily updates and videos with BSU's largest social media network for BSU Sports -- Ball State Sports Link.
Like SL on Facebook:
www.facebook.com/BallStateSportsLink and Follow SL on Twitter: @bsusportslink.


text:
The first day that John Swogger came to Altoona to meet his new staff and team was during the summer of 1968.
I was part of a group that met him for lunch at the Penn Sill Hotel. We were to eat at noon and meet with the team at Roosevelt Junior High School at 1 p.m. John was being driven around Altoona by a delegation from the high school, and they were a few minutes late in arriving for lunch.
It was around 12:40 p.m., the lunches had just been served, when John stood up and said, "We're leaving."
While I had coached against him when I was the varsity assistant at Bishop Guilfoyle, this was my first introduction to his coaching style. Nothing was more important than being on time to meet the team. The expectation was that the coaches would set the bar, and John wanted the bar set high. The lunches were left behind, and we headed for the gym. Being late was not an option.
Through the years, I have heard many views and myths about the man. All I can tell you is what I observed.
In the year that I served as an assistant, while I saw a very persistent coach, I never heard John swear, and I never observed him touch a player. I know that there are those who have thought that he was a terror in the locker room. The truth be told, he inflicted more damage to scoring tables than he ever did to any locker room. The locker room chats were punctuated more by long periods of silence than they ever were by verbose diatribes.
John was more of a teacher than he was a coach. The gym was his classroom. And the methodology was drill and practice mixed with holistic learning. There is a saying among coaches that "practice doesn't make perfect, perfect practice makes perfect."
That sums up working with John.
As John grew older, the mystique about him began to change. Even his role changed. When he retired as a coach in 1980, John slowly made the official move from coach to teacher. He began to work more with individual students and less with teams. And, as he did, his students were making a transition with him. They were less driven to clear the high bar that was established and more driven to learn and grow. In fact, John took on an almost rock-star persona. When he entered a gym to watch a high school game, young players would flock to him, calling out to him, "Coach Swogger, Coach Swogger."
They wanted to high five with him and hoped to hear one of his compliments.
And it was in paying attention to those compliments that one would begin to understand the nature of John Swogger. He didn't deal in superlatives. Rather he said things simply. He often would say something like, "Billy Moore, he was a good one." Only after having spent enough time with him in a gym would you come to understand that, "he was a good one" meant that John was giving the highest compliment.
"He was a good one," meant, he was in the 99th percentile. "He could play" put that person in the next highest ranking.
So when John called one of his chargers over and introduced him or her to you and said, "Coach, he [or she], is going to be a good one," you knew to begin watching for that player's name.
They came from all over. They were from "up the mountain," to "out in the Cove," to "down the valley." But John knew them all, and they all knew him.
During the last couple of decades, John became the Dean of the area's coaches. It was an unofficial honor that was bestowed on him by those of us who knew him. Other than being with his family, John was happiest when he was in the presence of those he coached, those he coached with and those he competed against. All were welcome to the Thursday morning breakfasts and to his annual Christmas party. And, during those times, the "Swogger" stories flowed and the "Swogger" legend grew.
I'm sure that the Thursday morning breakfasts will continue. And I'm also sure that the stories about John Swogger will continue to flow. And if you ever happen to be around that table, if you ever hear those in attendance talk, and you hear one of them say, "Coach Swogger, he was a good one," well, I think you'll understand what they mean.
Tony Labriola
A 'gentleman,' he touched many lives
I can't imagine many programs in the area, boys or girls, that didn't have a player or players that weren't touched by Coach John Swogger.
My story isn't unlike so many others. Coach worked with both of my daughters and helped them a great deal - not only on the basketball court but in the game of life. When our oldest earned a scholarship to play Division II basketball, we invited Coach out to breakfast with the rest of our family to celebrate.
I'm sure he had other things to do that day, but he was there to share in something he had a large part in. I've heard all the stories about the fiery coach, and I could still see it in his eyes when a drill wasn't done right or a player's attitude might not be what it should be during a workout.
But the man I knew was a true gentleman.
He could reach the kids and get them to push beyond what they thought they were capable of doing but always in an upbeat and positive manner. He did not only know all the names of the kids, he would be teaching but knew them as people, too.
I didn't see Coach as much over the past few years with both of my daughters graduated and done playing, but I was looking forward to seeing him soon because I knew he would be out to our holiday tournament to watch his girls play. He never left the gym until he got a chance to say hello and ask about the family.
As I got into coaching, there wasn't a practice that went by that I didn't think of something Coach said or taught. What's the most important shot in basketball? Anyone who was around Coach knows the answer.
Like everyone else, I could go on forever, but there is just one thing I'd like to say to Coach's family that I said to him many times. Thank you. Thank you so much for sharing such a wonderful person. He has touched countless lives in a manner that some of you will never know.
I've never been around a person with such a passion to be around our youth and teach them the game he loved so much. There is a huge void in our basketball community that cannot be filled by any one person but as those players he helped so much continue on, have families of their own, some get into coaching themselves, they will pass on those values and lessons that Coach taught them to the best of their abilities.
God bless you, Coach. You will be sadly missed.
Mike, Andrea Horton
Tara Stock and Kiely Horton
(Editor's note: The writer is an assistant coach for the Central High School girls basketball team.)
Moore made Swogger proud
I'm really sorry to learn of the passing of John Swogger.
He was quite the coach, teacher and gentleman in his days. Growing up and playing in Tyrone. I had the opportunity to play against his teams a couple of times while in high school. I always felt that Swogger and John Wiberg, who was my coach at Tyrone, were the two best coaches, teachers, educators and gentlemen that I was ever around.
Living in the Houston area, we were fortunate to see Johnny Moore play often with Texas as they were then in the old Southwest Conference.
I had been introduced to Johnny when he was in high school by Coach Swogger years earlier, and when we saw him play against the Houston Rockets, when the Spurs were in Houston, he was always the same gracious and well mannered Johnny Moore from Altoona.
He never changed - a credit to his family and his coach.
Will Walk
Spring, Texas
Blair County loses an icon
The Mifflin County basketball community is saddened to hear of the passing of John Swogger.
Coach Swogger was always quite supportive of our Lewistown girls basketball teams, and he never forgot to invite us to participate in the numerous leagues he organized at various venues in the Altoona area.
Having our girls play in leagues created by Coach Swogger paved the way for our program to reach new heights on the District 6 and PIAA levels. Even last year, our first year of Mifflin County High School, Coach Swogger called to wish me luck before the season, and we were delighted to participate in a fall league that he created.
Each season, Coach always made it a point to come to one of our games when we were in the Blair County area, and I will never forget his support and encouragement.
Blair County has certainly lost an icon. Our prayers are with his family and friends.
Kevin Kodish
Girls Basketball Coach
Mifflin County High School
Legend will continue to grow
Revered and feared, cheered and jeered, steady and unwavering in the pursuit of perfection, men like Coach John Swogger set standards and have expectations of their players and fans that can only be fully appreciated in hindsight.
The loss that the Swogger family feels at this time is shared by tens of thousands of others who had the privilege of experiencing the Swogger method during the decades that he shared his knowledge and love of the game with anyone willing to pay attention.
His legend will continue to grow as the years go by as those he touched share their memories of how he had a positive effect on their lives, both on and off the court. Few people achieve greatness in life without a mentor - someone like Coach Swogger - to show them how to excel at the game of life.
Goodbye, Coach. Take those 20 little kids from Connecticut by the hand and show them how to play the game the Swogger way.
Chip Clarke
Roaring Spring


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Mr. and Mrs. Mendelssohn Hoxie, Jersey Shore, observed their 65th wedding anniversary Aug. 30, 2012.
They were married by the late Rev. Charles N. Ouderkirk, father of the bride, at St. Paul Methodist Church, Syracuse, N.Y.
Mrs. Hoxie, the former Pauline Ouderkirk, is a native of Syracuse. She is the daughter of Norine (Ames) and Charles N. Ouderkirk. She graduated from Onondaga Valley Academy, Syracuse, in 1946. She attended Powelson Business Institute of Syracuse. She was employed by Syracuse University Hospital as a medical secretary and by Jell-o Co., LeRoy, N.Y. She retired from ManorCare as a social service director and purchased an arts and crafts business in Lock Haven, which she and her husband operated until 1984. She is employed part-time by Comfort Keepers.
Article Photos
Mr. Hoxie is the son of the late Mildred (Miller) and Vern Hoxie. He graduated from Onondaga Valley Academy in 1940, and received a bachelor's degree in journalism from Syracuse University in 1947 and received a master's degree in education. He served in the Marines in Iwo Jima during World War II from 1942 to 1945. He was employed by the LeRoy Gazette for three years as managing editor. He also was employed by Byron-Bergen Central Schools, Bergen, N.Y., as a teacher from 1953 to 1964. He also was employed for three years by the former Williamsport Area Community College, now Pennsylvania College of Technology, as assistant to the president and was personnel director at Jersey Shore Hospital for two years.
They are the parents of three daughters, Susan Elizabeth, Frankfurt, Germany; Janice Lee Rivera, Avis; and Anne Norine Bittner, Round Hills, Va.
There are four grandchildren and one great-grandchild.


text:
Top Definition
A kinky sort of feeling, when you want someone to make you feel like your wanting more and more.
He made me feel so Jinxy lastnight!
dodane przez BPGK kwiecień 12, 2014
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Can you define these popular missing words?
Sketchy or iffy.
John is so jinxy, he sleeps like a bear and never goes out.
dodane przez Pizzuhgurl marzec 09, 2009
(n) a person who will take any given number from two to fifteen days to clean her room, overuses the tilde as a punctuation mark and the hybrid expression "<3"; other than that a very friendly and sincere person who tries her best to help around.
OMFG teh JINXY! <3<3
dodane przez Teeheehee styczeń 21, 2005


text:
Accidentally Sneaking Into America from Mexico: A True Story
Chapter 4: Wherein I Prepare to Start Over and Carve Out a Life in Mexico
Holly Wilmeth
We pulled over and jumped down from the truck to see that the ropes were still secured around the bumper, but that the bumper had given up on the Dodge Raider. It was dragging in the street behind us like a dog that refuses to walk any farther and demands to be carried. Everything I had of importance, including my passport and also my friends, were in the Raider. I was with a stranger in the middle of a border town at night with about seven dollars in my pocket. The little boy looked at the bumper, then he turned to me and laughed in my face.
Thankfully, the kindly man didn't abandon me at my weakest moment. Instead, he tossed the bumper in the bed of the dump truck and we climbed back into the cab and retraced our steps through the city. It took us about 40 minutes to find the Raider pushed drunkenly to the side of the road in a busy intersection. My friends were already pulling everything they owned out of the Raider. "I'm leaving it," my friend Jesse told me. "The whole thing is worth less than a new engine." The gentleman with the terrible son expressed interest in taking it off our hands in exchange for the ride. We consented and piled into the bed of the dump truck so he could drive us the rest of the way to the border.
Chapter 5: Wherein We Bravely Lose Our Way to the Station and Sneak Across the Border by Mistake
Gary Moon
A little less than a mile out from the station, our hero and his heartless son dropped us off on the side of the road and said they couldn't go any farther. We were pretty confident we could walk a mile with pillows, a boom box, and duffel bags under our arms, so we said our goodbyes and thank yous and then immediately got lost. We walked for what felt like a mile in what felt like the right direction but never stumbled across anything that felt like border patrol.
When we finally did see something that resembled a station, we opted to take a shortcut there, squeezing between bushes, jumping over loose boards in a muddy ravine, and climbing through the broken chain-link fence of a construction site. Between where we left the road and where we found it again couldn't have been farther than the length of a football field, but in that distance we inadvertently found the most accommodating illegal entry point into Calexico for probably hundreds of miles, and no one was there. The lights we had been aiming for didn't belong to a border station after all, but to a factory. By the time we found the legal point of entry and realized our mistake, we all just stood there looking at it, quietly deciding it would be too embarrassing to go back through a second time and explain why we were muddy, carless, and trying to get into the U.S. while already standing in the U.S.
Epilogue: Wherein None of Us Get Shot by Minutemen and We Eat French Fries in a Greyhound Station
Nick Cowie
"I'm glad no one shot us," Jesse said while we waited for our bus. We agreed that was our favorite part, but said nothing, because we were all eating french fries from the fast food restaurant next door.
It took us four hours to get to Los Angeles, and along the way I tried to extract some overall thesis from the experience, because I was a freshman in college and I thought that's what I was supposed to do with everything. I couldn't understand why the dump truck driver had helped us in the first place or why he circled back with me when we lost the car. I certainly never would have done that for anyone, but then again I didn't own a dump truck and maybe there was some code of ethics.
Or perhaps he found himself in a similar situation once. Perhaps he felt the same impulse as I did, an impulse so strong, it doesn't belong to each individual man but to all mankind, binding us together despite our cultural differences and the borders between us: The impulse to jump a car in the air until it breaks.
Or maybe he just felt bad because I almost cried when his son laughed at me. Man, I hated that kid.
Special thanks to Dan Campagna, Sam Bergen, Olly Calleja, and Jesse Johnson.


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Top Definition
To knock around the nozzle of a gas pump while it's still in the tank to get the last bit of gas out so it doesn't leak on your car or your shoes when you take it out.
Mom to young son who is filling her car with gas: "Don't forget to 'spank the nozzle'."
додав euphemismo 18 Серпня 2013
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text:
I so do agree with this. I never uderstood why men would get higher PCS scores than women.change the PCs factors so they are the same for men and ladies
Yeah. The idea why the pcs are different is so that the technical and presentation scores in each discipline could be similar. It can get confusing to the audience if there was a great discrepency in points between the technical and presentation mark. That is why they factor the pcs
^ Still, I think an even more important feature of the IJS is the concept of a "balanced program." In particular, the factoring maintains a balance between technical elements and the program as a whole.
Without factoring, a skater might get, let's say, 45 "absolute" points in PCS. This would correspond to straight 9.0s across the board. Here is how that would work out for a men's and a ladies' short and long programs, without factoring.
Men's SP: TES 45, PCS 45, Total 90. Program components comprise 50% of the total.
Men's LP: TES 90, PCS 45, Total 135. Program components comprise 33% of the total.
Ladies' SP: TES 36, PCS 45, Total 81. Program components comprise 56% of the total.
Ladies' LP: TES 72, PCS 45, Total 117. Program components comprise 39% of the total.
The factoring adjusts all of these "expected" ratios to 50%. This is kind of an overall expectation built into the system. Of course an individual skater might be stronger in technical elements than in presentations skills, or vice versa.
Proposal to remove Figure skating in olympics...... since no matter what changes they made as long as people who leads skating is corrupt.... the sport itself is corrupt.....
Judging is de facto relative. As Sonia Bianchetti call it: Absolute judging: a utopian delusion.But I agree that having different factors implies that judging is relative and not absolute, which isn't exactly the basis on which IJS was created


text:
Top Definition
The type of slop that you shit the mornign after a night of drinking Budweiser.
I had the worst case of Bud Mud this morning.
dari todd Senin, 29 Desember 2003
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An uncontrollable case of diarrhea, or other loose-stooled B.M. stemming from consumption of alcohol, generally cheap alcohol.
After a long night of hammering Milwaukee's BEAST, Peter woke up with a severe case of the Bud Muds.
dari somuchmud Minggu, 06 November 2005
The shit that works it's way out of your colon after a night of smoking the chronic.
Man you should have seen the bud mud i left in the shitter this morning
dari JerseyJohn Kamis, 03 April 2003


text:
Systemwide Events Calendar
Campus-Wide ConversationJanuary 28, 12:00pm - 1:00pm
Manoa Campus, Kuykendall Auditorium
UHM students, faculty, staff, administrators and other interested members of the campus community are invited to participate in January's Campus-Wide Conversation.
Agenda topics: Sustainability and Academic Rigor
Event Sponsor: Office of the Chancellor, Manoa Campus
More Information: Diane Chang (808) 956-0391, email@example.com
Event Sponsor
Office of the Chancellor, Manoa Campus
More Information
|Monday, January 28
|The Wellness Center - Fitness Class Schedule
Maui Campus, Pilina Bldg., Wellness Center
|Don't Be Shady: Stalking Awareness
Manoa Campus, Campus Center
|Campus-Wide Conversation
Manoa Campus, Kuykendall Auditorium
|Undergraduate Research Opportunities Info Session
Manoa Campus, Sinclair - Honors Lounge (1st Floor)
|Bollywood Mondays: 'No One Killed Jessica' (2011)
Manoa Campus, Marine Sciences Building 114
|Zen Philosophy Club - Level 1 Class (Introduction to Zen)
Manoa Campus, Hemenway 204
- Highlighted dates have scheduled events.
- Select the date to view all events for that day.
Ongoing Events
- Scholarships Available!
- Lineage : A Family Tree of Printmakers
- Diversity and Equity Initiative Grants for Spring 2013
- 35th Annual Graduate Art Exhibition
- The White Rose : nonviolent resistance against the Nazi regime
- Biggest Loser Challenge Sign-Up
- Arts Exhibition: Ainu Treasures: A Living Tradition in Northern Japan


text:
Top Definition
the man lays down with his eyes closed and the girl sneaks up and BLOWS the hell out of him
johnny asks sally if she wants to play the Pearl Harbor game. Sally asks what do i do? Johnny says i'll lay down over here with my eyes closed and you sneak up and blow the hell out of me. Sally says yummy
dodane przez harrdcore92 lipiec 08, 2012
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text:
What are fungal infections?
Fungal infections represent the invasion of tissues by one or more species of fungi. They range from superficial, localized skin conditions to deeper tissue infections to serious lung, blood (septicemia) or systemic diseases. Some fungi are opportunistic while others are pathogenic, causing disease whether the immune system is healthy or not.
Fungi are one of four major groups of microorganisms (bacteria, viruses, parasites, and fungi). They exist in nature in one of two forms: as unicellular yeasts or as branching filamentous molds (also may be spelled as "moulds"). Some fungi are dimorphic – they change from one form to another depending on their environment. While yeasts cannot be seen with the naked eye, molds can be seen as the fuzzy splotches on overripe fruit or stale bread, as mildew in the bathroom shower, and as mushrooms growing on a rotted log. There are more than 50,000 species of fungi in the environment, but less than 200 species are associated with human disease. Of these, only about 20 to 25 species are common causes of infection.
Most fungal infections occur because a person is exposed to a source of fungi such as spores on surfaces, in the air, soil, or in bird droppings. Usually, there is a break or deficiency in the body's immune system defenses and/or the person provides the "right environment" for the fungi to grow. Anyone can have a fungal infection, but certain populations are at an increased risk of fungal infections and recurrence of infections. These include organ transplant recipients, people who have HIV/AIDS, those who are on chemotherapy or immune suppressants, and those who have an underlying condition such as diabetes or lung disease.
Infections involving fungi may occur on the surface of the skin, in skin folds, and in other areas kept warm and moist by clothing and shoes. They may occur at the site of an injury, in mucous membranes, the sinuses, and the lungs. Fungal infections trigger the body's immune system, can cause inflammation and tissue damage, and in some people may trigger an allergic reaction.
Many infections remain confined to a small area, such as between the toes, but others may spread over the skin and/or penetrate into deeper tissues. Infections that progress or start in the lungs may spread to the blood and be carried throughout the body. Some superficial fungal infections may resolve on their own, but most serious infections require medical attention and may need to be treated for extended periods of time. Those that penetrate into the body typically increase in severity over time and, if left untreated, may cause permanent damage and in some cases may eventually cause death. A few fungal infections may be easily passed on to other people, while others typically are not contagious.
Fungal infections may be categorized by the part of the body that they affect, by how deeply they penetrate the body, by the organism causing the infection, and by the form(s) that the fungi take. Some organisms may cause both superficial and systemic infections.


text:
Oral Cancer Center - Duluth, MN
- WebMD Physician Directory of Duluth Oncologist Doctors
- Related Oral Cancer Articles
- Duluth Emergency Contacts
- Nearby Duluth Hospitals
- Find a Local Pharmacy on RxList - Duluth
Duluth Oncologist Doctors for Oral Cancer
Type of Physician: Oncologist
What is a Oncologist? A subspecialty certification by the Board of Internal Medicine; the oncologist specializes in the diagnosis and treatment of all types of cancer and other benign and malignant tumors. These subspecialists decide on and administer chemotherapy as well as consult with surgeons and radiotherapists on other treatment for cancer.
Specialty: Oncology (Medical)
Common Name: Cancer Doctor
Oncologist Doctors in Duluth * results
- 2
Lloyd H. Ketchum
Essentia Health Emergency Medicine
420 E 1st St
Duluth, MN 55805
(218) 786-3625
- 20 years experience
- 2 office location(s)
- 3
Steven R. Bonin
St Lukes Radiation Oncology
1001 E Superior St Ste L101
Duluth, MN 55802
(218) 249-7880
- 24 years experience
- 1 office location(s)
Don't see your city? Use the WebMD Physician Directory to expand your search.
Oral Cancer
Oral cancer facts*
*Oral cancer facts medical author: Charles P. Davis, MD, PhD
- The oral cavity is complex and consists of lips, cheek lining, salivary glands, hard palate, soft palate, uvula, area under the tongue, gums, ...
Other Related Oral Cancer Articles
Emergency Contact for Duluth
- In case of Emergency, call 911
Nearby Duluth Hospitals results
- 1Essentia Health-Duluth
502 E 2nd St
Duluth, Minnesota 55805
(218) 727-876
- 2Essentia Health-St Mrys Med Ctr
407 E 3rd St
Duluth, Minnesota 55805
(218) 726-400
- 3St Luke's Hospital
915 E 1st St
Duluth, Minnesota 55805
(218) 726-555
- 4Essentia Hlth St Mrys Hosp Supr
3500 Tower Ave
Duluth, Minnesota 54880
(715) 392-828
- 5Community Memorial Hospital
512 Skyline Blvd Ste 1
Duluth, Minnesota 55720
(218) 879-464
- 6Lake View Memorial Hospital
325 11th Ave
Duluth, Minnesota 55616
(218) 834-730
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Places to play AirSoft in Manila?
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text:
EBENSBURG - While neither coach was sure if the shot was in time, and both coaches disagreed on its importance, an off-balance three pointer by Brandon Martinazzi at the end of the first half changed the momentum for both Bishop Carroll and Central Cambria in the title game of the County Seat tournament at Central Cambria High School.
Martinazzi's shot came off a scramble with time running out in the first half. The ball rolled out to the top of the three point arc after both teams fought for the ball under the basket. Martinazzi grabbed the ball and tossed it at the basket close to the sound of the first half horn. The ball went into the basket, cutting Central Cambria's halftime lead to 25-24.
The Huskies came out of the locker room with and quickly took control of the game. They opened the second half with a 10-2 run to open up a seven point lead, and controlled the game the rest of the way. Bishop Carroll made 11 of 14 free throws in the final quarter to secure the County Seat Tournament title with a 59-50 victory over Central Cambria.
"I'm not sure if that [Martinazzi's three pointer] sparked us, or if my halftime speech sparked us," said Bishop Carroll head coach Cosie Aliquo. "I don't even know if the shot before halftime was good. I won't even know until I look at. What sparked us is that we came out in the third quarter and we got bucket, and we got a couple of steals. That put us up to seven, and that sparked us. Then Marcus started to attack the basket, and we got some buckets off of that."
Bishop Carroll only held one lead, 11-10 early in the second quarter, before they took the lead for good on a Scott Ranck bucket with 6:47 left in the third quarter. Ranck followed that with a layup that pushed the lead to three points. A Lee reverse layup and a foul line jumper by Ranck capped the Huskies 10-2 run to start the second half, and forced the Red Devils to take a timeout trailing 34-27.
Central Cambria made a run late in the quarter, and cut the Bishop Carroll lead to 38-35 on a Gino Tsikalas layup with 36 left in the third frame. However, Martinazzi made a layup, then stole the inbounds pass and made another layup in a couple of second span to push the lead to 42-35 with eight minutes to play.
Both teams traded points early in the fourth quarter before the Huskies used a 7-0 run midway in the final frame to push their lead to a game high 13 points, at 53-40. Bishop Carroll then secured the win at the free throw line, making 11-14 foul shots in the final quarter to earn the 59-50 win.
"That's something that we do in practice a little more now than we have in the past, is practice foul shots," said Aliquo. "I always tell our guys it comes down that at end of the game. We have five guys out there shooting with confidence."
Central Cambria actually had the better of the play in the first half. The Red Devils twice held a four point lead in the first quarter before taking a 10-9 lead after eight minutes of play. After seeing the Huskies take their only lead of the first half, 11-10, on a Ranck basket, the Red Devils quickly regained the lead, and slowly built it over the rest of the half. A Tsikalas basket with 2:29 left in the half gave Central Cambria them a five point lead at 20-15. Martinazzi immediately responded with a three pointer, but Ambrisco answered with a trey of his own to push the lead back to five, at 23-18. The lead was four points before Martinazzi threw in his off-balance three pointer at the end of the half to cut the Red Devils lead to 25-24 at intermission.
"It was a huge momentum changer," said Central Cambria head coach Adam Stephan of Martinazzi's three pointer. "I'm not sure it was on time, but they called it good and it was a huge momentum swing at halftime. Instead of going in with a four point lead we go in only up one. We kind of got a little out of sync in the second half. We weren't attacking the way we were in the first half, and we weren't moving the ball with confidence like we did in the first half."
Blairsville took the consolation game in a very physical contest. The Bobcats jumped out to an 18-8 lead after one quarter, and pushed their margin to 16 points early in the second quarter. However, some physical play on both sides led to a combined 14 foul shots in the second frame. Penns Manor took advantage and closed the half on a 13-5 run that cut the Blairsville lead to eight points at intermission.
Penns Manor was able to cut the lead to two points early in the second half, but Blairsville recomposed themselves, and pushed the lead back to seven points by the end of the third quarter. They outscored the Comets 15-12 in the final frame to win the consolation game 62-52.
GAME NOTES: Central Cambria alumnus and Penn State quarterback Shane McGregor, along with Cambria County Commissioner Tom Chernisky, handed out the team and individual trophies after the title game. The All Tournament Team consisted of: Casey Jewart of Penns Manor, Troy Williams of Blairsville, Scott Holsinger and Tanner Ambrisco of Central Cambria, and Scott Ranck of Bishop Carroll. Brandon Martinazzi, who scored 50 points in the tournament, 26 of them in the title game, was named the tournament MVP.
CENTRAL CAMBRIA (50): Seymour 1 0-1 2, Bowman 1 0-0 2, Holsinger 5 4-10 14, Hodgson 3 0-0 7, Ambrisco 7 4-4 21, Tsikalas 2 0-0 4, Homan 0 0-0 0, Berzonsky 0 0-0 0, Magley 0 0-0 0, Leary 0 0-0 0. Totals 19 8-15 50.
BISHOP CARROLL (59): Madonna 1 3-5 5, Martinazzi 8 7-8 26, Lee 4 2-2 10, Maruca 0 0-2 0, Ranck 6 2-2 14, Sukinos 1 0-0 2, Lucas 1 0-0 2, Shuty 0 0-0 0. Totals 21 14-19 59.
Central Cambria10 15 10 15-50
Bishop Carroll9 15 18 17-59
3-point field goals: Central Cambria 4 (Ambrisco 3, Hodgson); Bishop Carroll 3 (Martinazzi 3).
Records: Central Cambria (2-7); Bishop Carroll (5-2).
PENNS MANOR (52): Hamilton 5 0-0 11, Kowalski 3 2-2 8, Rizzo 3 0-0 6, Horwat 0 3-4 3, Jewart 5 2-3 12, Tomayko 2 1-1 5, Alter 0 1-2 1, Foreback 0 0-0 0, Sink 0 0-0 0, Carrick 3 0-0 6. Totals 21 9-13 52.
BLAIRSVILLE (62): Helm 5 2-2 13, Ratkus 2 1-4 5, A. Horchar 2 0-0 4, R. Horchar 5 0-1 11, Williams 6 1-2 13, Sisitki 2 0-0 4, Faulk 1 1-3 3, McMillan 1 4-7 6, Rydbom 0 2-4 2, Henderson 0 1-2 1. Totals 24 12-25 62.
Penns Manor8 15 17 12 - 52
Blairsville18 13 16 15 - 62
3-point field goals: Penns Manor 1 (Hamilton); Blairsville 2 (Helm, R. Horchar).
Records: Penns Manor (0-7); Blairsville (5-5).


text:
Top Definition
When your having sex with a girl in the doggie style position and when you are about to cum, you cum in your hand and when the girl turns around you sling it in her face like spidermans web
we don't superman no moe, we just spiderman that hoe.
Daniel Jenkins tarafından 20 Eylül 2007, Perşembe
Trending Now
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when a guy is getting head he pullz out and nutz in his hand then fliks it at the grils face while doing the spider man sign
she wouldent swallow so i SPIDERMAN that hoe
wizeguy tarafından 11 Eylül 2007, Salı
Is when you are fucking someone in their ass, then ejaculating on your hand, then when they turn around, you shoot in on their face like Spider-Man.
You have to Spider-Man that hoe.
lolololololollooolllo Master Chief tarafından 10 Aralık 2007, Pazartesi
when a guy is fucking someone without a condom and does the withdrawal method, and he jacks himself off to finish and flings the cum at the girl, preferably in her face, while doing the spiderman hand sign.
we don't superman no mo, we just SPIDERMAN THAT HOE
chingaling tarafından 30 Eylül 2007, Pazar
wrap her up and leave her
"we dont superman no more we just spiderman that hoe"
Nicole Ashley tarafından 5 Eylül 2007, Çarşamba


text:
Eco friendly, award winning, quiet family
friendly campsite for tents and small campervans on the beautiful
North Norfolk Coast
VW Campervan enjoying the North Norfolk Coast sun on the Upper Paddock
at Deepdale Camping ... Tents on the Lower Paddock ... Tent and bike
(top) and campsite toilet & shower block (bottom)
Deepdale Camping is a quiet, family friendly, North Norfolk Coast campsite for tents and small campervans. Five well kept paddocks in the heart of the beautiful village of Burnham Deepdale, offering the perfect base to discover the North Norfolk Coast all year round. An 'Area of Outstanding Natural Beauty'*, famous for it's nature and bird reserves, walking, cycling, watersports and history.
Open All Year
Caravans (Sorry)
We have been
recommended by
Cool Camping!
If you are looking for a party campsite, then this isn't
the campsite for you.
We have a strict noise policy in the late
evenings to keep the relaxed atmosphere for both our customers and the
adjacent houses.
Deepdale Camping is open
all year for tents (Standard pitches tents no larger than 6.5m with guy
ropes, Jumbo pitches are for larger tents up to 10 meters) and small campervans –
sorry no caravans. At the moment we don't
offer electrical hookups or allow
We are an eco friendly
north Norfolk campsite, for more information please click here.
Click here to
book online
Modern clean campsite showers & toilet facilities
The campsite offers modern toilet,
and washing up facilities.
Like the
rest of the site these are
eco friendly
being heated by solar
panels, with a
backup oil boiler.
Advanced bookings for the period between
22nd July & the end of August Bank Holiday weekend must be made for a minimum of 7 nights.
We recommend you book ahead for all weekend
stays and peak periods.
Sorry, but we cannot guarantee specific pitch numbers,
for camping or campervans, as we
may have to rearrange to accommodate other bookings.
Clean hot showers
We are currently landscaping the campsite, by planting a huge
number of trees and hedges next to pitches and to divide the paddocks
better. Some of the new hedges are now establishing well and further
landscaping will be taking place.
This North Norfolk Coast campsite is not suitable for large groups.
Deepdale Camping - campsite for tents & small campervans, in Burnham Deepdale on
the beautiful North Norfolk Coast
Jumbo Pitches
Due to popular demand we now have 10 new Jumbo pitches at the top of our
Glebes. These pitches are for tents up to 10m and up to 2 cars
(Minimum of 4 people). The
pitches will fit an 8-10 man tent, or 2 smaller tents or campervans. If
you are bringing a boat or trailer we would also recommend a Jumbo pitch
to give yourselves room.
Standard Pitches
Deepdale Standard pitches fit a standard size 6 man tent and 1 car. These pitches are for tents up to 6.5m with guy ropes. These pitches are
what have been in place at Deepdale for many years and have proved
popular with couples and families alike. (High Season - Minimum
2 people per pitch)
(Saver Season Weekends - Minimum
2 people per pitch)
REMINDER: All
weekend stays are a minimum stay of 2 nights
(Friday & Saturday or Saturday & Sunday)
Jumbo Pitches
Camping &
per night
Low Season
Saver Season
Adults (per person)
For camping bookings in
Friday and Saturday nights must be booked together not separately
Over bank holidays the weekend and pre bank holiday nights must be
booked together.
(eg August Bank Holiday when Monday is the Bank Holiday,
Sunday night must be booked with the Friday and Saturday)
Standard Pitches
Camping &
per night
Click here
to book online
Just in case you can't
leave your
your social networking
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Copyright Deepdale Leisure Ltd -
Tuesday, 29 March 2016


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- Color
- a-list
an award-winning classic creamy red.
gain instant celebrity with this award-winning, classic creamy red polish. this vip lacquer is more than a brush with fame, it's a nail color star that's here to stay.
|Ethyl Acetate, Butyl Acetate, Nitrocellulose, Propyl Acetate, Tosylamide/Formaldehyde Resin, Isopropyl Alcohol, Trimethyl Pentanyl Diisobutyrate, Triphenyl Phosphate, Ethyl Tosylamide, Camphor, Stearalkonium Bentonite, Diacetone Alcohol, Stearalkonium Hectorite, Benzophenone-1, Citric Acid, Colophonium, Rosin, Silica, Synthetic Fluorphlogopite, Alumina, Dimethicone, Aluminum Calcium Sodium Silicate, Hydrogenated Castor Oil, Calcium Aluminum Borosilicate, Tin Oxide, Polyethylene Terephthalate, Calcium Sodium Borosilicate, Polyurethane-11, May Contain (+/-):, Titanium Dioxide (CL 77891), Mica, Barium Sulfate (CI 77120), CI 77491, Iron Oxides (CI 77499), Red 34 Lake (CI 15880), Yellow 5 Lake (CI 19140), Red 7 Lake (CI 15850), Red 6 Lake (CI 15850), Ferric Ammonium Ferrocyanide (CI 77510), Bismuth Oxychloride (CI 77163), Black 2 (CI 77266), Aluminum Powder (CI 77000), Ultramarines (CI 77007), Blue 1 Lake (CI 42090), Ferric Ferrocyanide (CI 77510), Red 34 (CI 15880), Red 30 Lake (CI 73360), Guanine (CI 75170), Yellow 11 (CI 47000), Red 30 (CI 73360), Violet 2 (CI 60725)
Start by applying 1 coat of the essie base coat that best suits your nail needs. Follow with 2 coats of your favorite essie shade. Finally top it off with one of essie's high performance top coats.
REVIEW SNAPSHOT®by PowerReviews
Reviewed by 2 customers
The most wonderful red!
By Peach
from NJ
describe yourself Classic, Trendy
- Dries Quickly
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Best Uses
Comments about essie nail colour Polish, A-List, .5 fl oz:
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The Best Red
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from NY
describe yourself Classic, Manicure/Pedicure Addict
- Dries Quickly
- Easy To Use
- Gentle
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Comments about essie nail colour Polish, A-List, .5 fl oz:
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I'm going to buy two more bottles pronto.
Bottom Line Yes, I would recommend this to a friend
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text:
Top Definition
Made famous by Dan Brown's book "The Da Vinci Code". The orginization was created as a fraud in the late 1960s, though it continues to exist as a myth.
"Did you know Isaac Newton led the Priory of Sion"
"Dude, that ain't real"
"Dude, that ain't real"
di Momoka 27 settembre 2006
Trending Now
Can you define these popular missing words?
The Priory of Sion was/is a brotherhood that keeps/kept an ancient secret concerning the heritage of Jesus Christ and The Holy Grail. They established the Knights Templar and cherged them with excavating the site under Herod's Temple in search of the grail itself.
He was the leader of the Priory of Sion.
di skinanbones08 08 marzo 2005


text:
Closed Captioned
Myra Wood will show you how to knit a top-down raglan bolero with endless lacy variations.
Make your cardigan a perfect fit by learning measuring tips and techniques for different body types.
Myra goes over the methodology of creating a raglan-sleeved, seamless bolero.
Test your yarn and needles by making gauge swatches, and learn the formulas for making perfect fit cardigans.
Begin knitting your cardigan with Myra's step-by-step instruction.
Join your yoke ends in preparation for knitting the cardigan body.
Learn to read lace charts and add the "Fan & Feather" lace pattern to your cardigan.
Knit in the round using the magic loop technique.
Add seed stitch trim to the edges of your cardigan.
Start incorporating complex lace patterns into your cardigan.
Use lace logic to incorporate multiple lace patterns in your cardigan.
Learn to add lace to your increase areas.
Introduce complex lace patterns to your cardigan body and sleeves.
Want to add buttons? This lesson will show you how.
"This course had enough instruction to qualify as a college course. Myra explained and demonstrated every technique simply enough so that I could create a beautiful well fit sweater. Myra answered my questions quickly and clearly. Kudos."
- Marie743
Lincoln California


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An Stor Townhouse
An Stór is a comfortable, family-run hostel in the heart of the busy town of Midleton. The original building was a wool store, now fully rebuilt to the highest standards. It is ideally suited to explore the South Coast of Ireland. There is free car-parking in our own car park. We are minutes from the bus-stops and train station.
All rooms are ensuite and many include double beds. Bedlinen is supplied and towels are freely available on request. The guest kitchen and lounge are spacious.
Meals can be provided for groups in our serviced kitchen and dining room. The town's Main Street is only a few minutes away wrere you can find lively pubs, award-winning restaurants and great shops.
The hostel has a ''No Smoking'' policy.
Free WiFi available
There is one ground-floor, wheelchair accessible bedroom and bathroom.
Hairdryer, iron /ironing board freely available
Laundry service available for a fee. We welcome pets
An Stór is close to many tourist attractions. Ideally, it is best to travel by car, but most sites are accessible by bus or train. Cork City is 20minutes away. Blarney Castle is to the north of the City. Cobh, with its cathedral and Queenstown heritage site is nearby as is Fota Wildlife Park. To the east of Mildeton is the Heritage Town of Youghal, with many tourist attractions and wonderful beaches. Lismore, over the border, in Waterford, is also a beautiful Heritage Town.
Availability & RatesTo view availability and prices please select dates and click 'Update Dates'
Hostel Facilities & Policies
- Adaptors
- Bicycle parking
- Common Room
- Credit Cards Accepted
- DVDs
- Telephone/Fax Facilities
- Free Internet Access
- Free Parking
- Free WiFi
- Hair Dryers
- Hot Showers
- Internet Access
- Self-Catering Facilities
- Laundry Facilities
- Linen Included
- Luggage Storage
- No Curfew
- Non Smoking
- Parking
- Pet Friendly
- Reading Light
- Restaurant
- Taxes included
- Tea & Coffee Making Facilities
- Towels Included
- Vending Machines
- Wheelchair Friendly
Cancellation PolicyThis property has a 1 day cancellation policy. Failure to cancel within this time will result in a cancellation charge equal to the first night of your stay.
DirectionsShow MapHide Map
Midleton is on the N25 east of Cork City. Take the Midleton train from Cork.If you phone ahead we can arrange to have you collected from the station We are 25 mins. drive from Cork Airport. Buses on the Cork/ Rosslare route stop on Main Street. Half way along the Main Street there is a sign post for An Str. Travel about 150m and as the street narrows, you will see another sign, pointing left. From this street corner the hostel sign is clearly visible. We can be found on SatNav.
If you need any further directions please contact us at 021 4633106
Located Near
When you leave the Hostel, the N25 will take you swiftly where you want to go.We are ideally located to visit Cork City, Blarney Castle, Cobh, Queenstown Heritage Centre,Fota Island Wildlife Park, Fota Island Golf. Barryscourt Castle, We are close to Jameson Whiskey Heritage Centre,Trabolgan Holiday Centre, Garryvoe Beach, the Heritage Towns of Youghal and Lismore, the Blackwater Valley and West Waterford.


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The Stetson men's basketball Junior Hatter Camp for boys aged 6-10 scheduled for June 10-13 has been cancelled. The Individual Camp for boys aged 9-15 running June 10-14 will still be held at the Edmunds Center.
For more information, head to the Stetson men's basketball camp page or contact Director of Basketball Operations Adam Jones: (386) 822-7336, firstname.lastname@example.com.


text:
Copyright © 2009-2016 TheMoneyCoach.net, LLC . All rights reserved.
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Lynnette Khalfani-Cox, The Money Coach, is not a certified financial planner, registered investment adviser, or attorney.
If you need specialty financial, investment or legal advice, please consult the appropriate professional.
Per FTC guidelines, this site may accept advertising, affiliate payments or other forms of compensation from companies mentioned.
AskTheMoneyCoach™ and Lynnette Khalfani-Cox, The Money Coach® are trademarks of TheMoneyCoach.net, LLC.
TheMoneyCoach.net, LLC is certified as a bona fide Minority Business Enterprise by the NMSDC.


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text:
The AANP has established a new process for providing Naturopathic CE. To apply, please download the application here. Please read it carefully and submit the application, including all attachments, in its entirety. Applications must be received no later than 45 days prior to the start of the activity. The AANP is committed to accrediting unbiased, non-commercial presentations whose goal is to further the well-rounded education of healthcare professionals. All presentations must be free from any commercial bias or product promotion.
Questions? Please contact Rebecca Takemoto at email@example.com.


text:
Road builders
Central Susquehanna Valley Thruway Project a go
November 27, 2013
SHAMOKIN DAM —Local lawmakers, state Department of Transportation and other officials gathered Tuesday afternoon to laud the new transportation law's authorization of $558 million over 10 years......
"Jim Barbarich, chamber board chairman and interim president, said the project has been three decades in the making and the bill is about safety, jobs and economic development. "This is key for companies relocating here," he said." Another validation of Obama's comment about not building it by yourself. Doesn't make him right about everything, but to argue his point as Republicans did in the '12 election was foolish.
2 Agrees | 1 Disagrees | Report Abuse »
The comments are all predictable. Same crap, different article.
1 Agrees | 1 Disagrees | Report Abuse »
"Oh, JOY!!! We get to fund SEPTA!"
Well Nobud I suppose people in Philly could say the same about the CSVT project. What benefit do they get. In fact I just read an article that the shale boom industry pushed this project. Funny it has been in the works for a long time now it will finally get done. Not much wonder Yaw and his republican buddies jumped on this.
2 Agrees | 3 Disagrees | Report Abuse »
"It shows how little these liberal legislators really understand about economics."--eriklatranyi
No, they understand economics, they just know that a majority of their constituents don't!!!!
2 Agrees | 2 Disagrees | Report Abuse »
If all the money generated from this went into the roads and bridges that would be great. I'd like to know (when I get time I'm going to check)how much of these funds will go into the general fund? I'd bet it's 50%. It all should go to the roads and bridges.
3 Agrees | 0 Disagrees | Report Abuse »
Oh, JOY!!! We get to fund SEPTA! These pols all see the cities as voting blocks to be coddled and cultivated at the expense of the rest of us who choose not to live in that mess. If SEPTA and and Pittsburgh's Port Authority can't make it on the fares they charge and taxes collected locally, then let them close up shop. We should not have to subsidize those operations. And now with the cap lifted from the gas tax there will be no end in sight. I really hate politicians, both sides of the aisle.
Erik, you are correct. These dolts think if you tax any business those costs will not be passed along to the consumer. And those who live on the govt dole think the same way. Very frustrating.
6 Agrees | 1 Disagrees | Report Abuse »
These moron Democrats think a severance tax on natural gas would not be passed on to the same seniors on fixed incomes.
It shows how little these liberal legislators really understand about economics.
5 Agrees | 3 Disagrees | Report Abuse »
$2.50 a week here, rising food prices over there, Obamacare's increased costs, stagnant wages - What the hey were you guys thinking? There well is running dry. We the man and woman on the street don't get the yearly increases and perks you folks get to help defray these non-essential cost increases. And yes they are non-essential increases the state receives more than enough to maintain and repair and build roads and bridges. I don't agree with the Democrats but I am starting to dislike the Republicans we elect even less. At least with the Democrats I know where I stand with Republicans it's like the old Indian saying, "white man speak with forked tongue".
5 Agrees | 1 Disagrees | Report Abuse »
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text:
And during Ariel Castro's hearing on Thursday, she proved to be a hero again when she delivered a powerful victim impact statement.
"I cried every night. I was so alone. I worried about what would happen to me and the other girls every day. Days never got shorter. Days turned into nights, nights turned into days. The years turned into eternity. I knew nobody cared about me. He told me that my family didn't care," Knight explained through tears. "Nobody should ever have to go through what I went through."
She mentioned her relationship with Gina DeJesus, calling DeJesus her "team mate."
"She never let me fall, I never let her fall. She nursed me back to health when I was dying from his abuse," she said. "My friendship with her was the only thing that was good out of this situation. We said that we would some day make it out alive and we did."
Knight then addressed Castro, describing how the captor would go to church every Sunday and then come home and abuse the three women.
"You took 11 years of my life away and I have got it back," she said. "I spent 11 years in hell. Now your hell is just beginning. I will overcome all this that happened but you will face hell for eternity. From this moment on, I will not let you define me or affect who I am. I will live on, you will die a little every day as you think about the 11 years and atrocities you inflicted on us."
She added, "The death penalty will be so much easier. You don't deserve that, you deserve life in prison."
Ariel Castro SpeaksWhen it came time for Castro to deliver his statement, he described himself as someone who suffered from sexual addiction, noting he was a victim of his addiction and not a monster.
"These people are trying to paint me as a monster, I'm not a monster, I'm sick," he said, stressing that he is not a violent person.
"They're trying to say that I'm a violent person, I'm not a violent person. I drove a school bus, I [was] a musician, I have a family," he explained during his lengthy remarks. "I do have value for human life because every time I came home, I would be so glad for [the] situation, as crazy as it sounds."
He continued, "These accusations that I would come home and beat them, those are totally wrong Your Honor. I know what I did was wrong. I'm not a violent person, I simply kept them there without being able to leave ... I just wanted to clear the record that I'm not a monster."
What Went on Inside the HouseThe women – Knight, Berry and Gina DeJesus – were terrified and degraded for about 10 years after being kidnapped and constrained with chains and zip ties while living in primitive conditions, according to a 22-page document submitted by the prosecutor's office Wednesday for Castro's sentencing hearing.
He was sentenced to life in prison plus 1,000 years for pleading guilty to more than 900 counts of rape and kidnapping, and expected to speak in his own defense in a Cleveland courthouse Thursday. Watch it live on Cleveland.com
"Very little movement was allowed throughout the house … They only had access to plastic toilets in the bedrooms. They were emptied infrequently," documents say. "He controlled the temperature and the inflow of food and drink. He used the cold of the basement and the heat of the attic as punishment techniques."
For years, the girls watched holidays, world events, and even the passing of Berry's mother from the now-boarded up house on Seymour Avenue. They kept diaries, which described the psychological and sexual abuse they endured, how they were treated like animals and prisoners of war, and their dreams of someday escaping.
Dr. Frank Ochberg, an expert on Stockholm Syndrome and traumatic memories, submitted an evaluation of the women after viewing police interviews on video, checking medical records and FBI reports. He says the women "managed to share faith and friendship" on the rare occasions they were allowed to be together. He adds that the women home-schooled Berry's baby and instilled "honorable values" when they could.
"This is the good news," he states. "But it does not in any way paint a rosy picture for normalcy or a quick recovery. Grave damage has been done."


text:
Quadruple Helices Appear To Have Role...
As Immunotherapy Revolutionizes the Cancer Treatment...
Developers of DTC Genetic Testing Are...
Expanding Use of NGS Has Largely...
Studies like these should extend the range of available substrates for firefly luciferase (Fluc), providing researchers new formulations for use both in vitro and in vivo. [© fergregory - Fotolia.com]
ASSAY & Drug Development Technologies offers a unique combination of original research and reports on the techniques and tools being used in cutting-edge drug development. The journal includes a "Literature Search and Review" column that identifies published papers of note and discusses their importance. GEN presents one article that was analyzed in the "Literature Search and Review" column, a paper published in Journal of the American Chemical Society titled "Expedient synthesis of electronically modified luciferins for bioluminescence imaging." Authors of the paper are McCutcheon DC, Paley MA, Steinhardt RC, and Prescher JA.
Bioluminescence imaging with luciferase enzymes requires access to light-emitting, small-molecule luciferins. Here, we describe a rapid method to synthesize D-luciferin, the substrate for firefly luciferase (Fluc), along with a novel set of electronically modified analogues. Our procedure utilizes a relatively rare, but synthetically useful dithiazolium reagent to generate heteroaromatic scaffolds in a divergent fashion. Two of the luciferin analogues produced with this approach emit light with Fluc in vitro and in live cells. Collectively, our work increases the number of substrates that can be used for bioluminescence imaging and provides a general strategy for synthesizing new collections of luciferins.
Luciferase assays are widely used in biochemical and cell-based assays. New luciferases isolated from various bioluminescent species continue to be developed to provide high-sensitivity bioluminescence assays. Firefly luciferase (Fluc) is the most commonly used reporter in cell-based reporter-gene assays (RGAs).
The bioluminescence of Fluc ranges from 500 to 700 nm with a broad emission peak at 550–570 nm. Although red-shifted variants of Fluc have been produced by mutating the D-luciferin binding site, these variant enzymes may show dimmer bioluminescence and many are not widely available. Another approach to developing luciferase assays with different emission maximums involves synthesizing new luciferins. This article describes a facile method to construct new luciferins using Appel's salt (4,5-dichloro-1,2,3-dithiazolium chloride).
The authors were able to synthesize luciferins with benzimidazole and imidazoline rings. Benzimidazoles are known competitive inhibitors of Fluc, and previous work has shown that such heterocycles can be excited to emit light. After obtaining these nitrogenous luciferins, these compounds were used as substrates for Fluc in the presence of ATP and CoASH. No bioluminescence could be detected for analog 3 (see Figure), and only a very weak signal was obtained for analog 4. However, analogs 2 and 15 showed detectable signals, although they were approximately 100-fold weaker than the one obtained with D-luciferin. The benzimidazole analog 2 showed a red-shifted emission maximum of 578 nm.
Interestingly, analog 15 showed a greatly blue-shifted emission peak compared to other luciferins with a λmax = 460 nm. This emission is similar to what is found with coelenterazine if used as a substrate for the luciferase isolated from Renilla reniformis. These analogs were also shown to function in a cell-based Fluc assay using HEK293 cells.
Studies such as these should extend the range of available substrates for Fluc providing researchers new formulations for use in both in vitro and in vivo studies.
Doug Auld, Ph.D., is affiliated with the Novartis Institutes for BioMedical Research.
Doug Auld, Ph.D., is affiliated with the Novartis Institutes for BioMedical Research.
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text:
Our friends at Misha Lulu (you know, our favorite) are a featured sale at The Mini Social today (Monday 6/21) - a great chance to snatch up some deeply discounted designs.
Not being paid to say this, just wanted to share the love. However I did just sign up (on my own free will, looked it up myself, wasn't asked to, etc!) for an account at The Mini Social and if you sign up, too, (and click my link or include my email as your referral [firstname.lastname@example.com] then I get a little bonus when you make your first purchase.)


text:
Simplify management of apps & devices
Microsoft Intune provides mobile device management, mobile application management, and PC management capabilities from the cloud. Using Intune, organisations can provide their employees with access to corporate applications, data, and resources from virtually anywhere on almost any device, while helping to keep corporate information secure.
Business case
Device choice
Provide employees with the ability to register, enroll, and manage their devices as well as install corporate applications from the self-service Company Portal – all from the devices of their choice.
Unparalleled management of Office mobile apps
Maximise mobile productivity for your employees with access to corporate resources on Office mobile apps they know and love. Keep your corporate data safe by preventing leakage of company data all without intruding on user's personal devices.
Modern BYOD
Utilise Mobile Application Management (MAM) without requiring the device to be enrolled for management. This is particularly important for BYO scenarios where IT wants to keep corporate data safe but doesn't want to risk intruding on a user's personal life.
Data protection
Secure corporate data, including Exchange email, Outlook email, and OneDrive for Business documents, based on the enrollment status of the device and the compliance policies set by the administrator.
No infrastructure required
Eliminate the need to plan, purchase, and maintain hardware and infrastructure by managing mobile devices from the cloud with Intune.
Enterprise integration
Extend your existing System Center Configuration Manager infrastructure through integration with Intune to provide a consistent management experience across devices on-premises and in the cloud.
Flexible licensing
Spend less time counting devices with per-user licensing for Intune. Intune is also included as part of the Enterprise Mobility Suite, the most cost-effective way to acquire Intune, Azure Active Directory Premium, and Azure Rights Management.
Global presence with 24/7 support
Get answers to your questions with Microsoft support available online and by phone worldwide – included with every Intune subscription.
Microsoft Intune in the news
Improving BYOD security with Microsoft Enterprise Mobility SuiteRead the article
Redmond Channel Partner
Microsoft to give Office 365 an MDM boost with IntuneRead the article
Microsoft's February Intune update adds new Android management featuresRead the article
Windows IT Pro
Microsoft ideally situated to own mobile device managementRead the article
Pub and restaurant company boosts service and satisfaction
Mitchells & Butlers wanted to deploy mobile devices that run service-enhancing apps to its staff at 1,600 establishments. The company subscribed to Intune to manage these devices remotely and expects to improve customer service, increase site managers' efficiency, and reduce costs.Watch the video
Golf company reduces costs, improves scalability by moving servers, services to the cloud
Callaway Golf uses Microsoft Intune to proactively manage sales computers and keep salespeople productive. It has also eliminated maintenance downtime that used to plague international offices.Read the case study
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text:
Contract talks to resume at Caterpillar
Both sides rejected each others' previous offers
It's back to the bargaining table for 800 workers at Caterpillar. They'll try to work out a new contract after union members rejected the company's last proposal.
According to our partners at BizTimes Milwaukee, union workers turned down a six-year contract on April 30. That proposal included frozen wages, higher costs for health care, and fewer seniority protections.
The union says it made counter offers about a week later, but the company didn't accept its proposals.
The union now says it will change its proposals to work toward a new contract.
These talks will not prevent some layoffs in June. That's when about 300 workers will lose their jobs.
Copyright 2013 by WISN.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Comparative Study of Microcontroller Controlled Four-Wire Voltage and Current Source Shunt Active Power Filters
Pettersson, Sami
Publication type: Doctoral dissertation
Issue date: 2009-05-29
Language: en
Belongs to: Tampereen teknillinen yliopisto. Julkaisu - Tampere University of Technology. Publication;810
Supervisor: Tuusa, Heikki
Salo, Mika
Salo, Mika
Opponent: Silventoinen, Pertti; Kyyrä, Jorma
University: Tampere University of Technology
Faculty: Faculty of Computing and Electrical Engineering
Department: Department of Electrical Energy Engineering
During the past two decades, active power filters have increasingly grown their popularity as a viable method for improving electric power quality. The main reasons for this have been the advent of fast self-commutating solid-state devices, the progression of digital technology and the improved sensor technology. Four-wire active power filters provide an efficient solution for improving the quality of supply in grounded three-phase systems or three-phase systems with neutral conductors, which are commonly used for powering residential, office and public buildings. Four-wire active power filters are applicable in compensating current harmonics, reactive power, neutral current and load phase imbalance. This thesis presents a comparative study of microcontroller controlled four-wire voltage and current source shunt active power filters. The study includes two voltage source topologies and a current source topology with two different dc-link energy storage structures, which are compared on the basis of their filtering properties, filtering performance and efficiency. The obtained results are used for determining the suitability of current source technology for four-wire active power filtering and finding the most viable four-wire shunt active power filter topology. One commonly recognized disadvantage of the current source active power filter has always been the bulky dc-link inductor. To reduce the size of the dc-link inductor, an alternative dc-link structure for current source active power filters was introduced in the late 80's. The hybrid energy storage consists of both inductive and capacitive energy storage elements, two diodes and two controllable semiconductor switching devices. Since the capacitive element is used as a main storage unit, the inductance of the dc-link inductor can be considerably reduced. However, the original dc current control method proposed is not able to utilize the full potential of the hybrid energy storage and the inductance required in the dc-link is still quite large. To solve the problem, this thesis presents an enhanced dc current control method for the hybrid energy storage that makes it possible to minimize the inductance of the dc-link inductor. The performance of the proposed method is experimentally verified by applying it to the four-wire current source active power filter topology. The results show that all topologies included in the study have good filtering performance, but the efficiency of the voltage source topologies is much better than that of the current source topology with conventional dc-link structure. However, by using the hybrid energy storage and the enhanced dc current control method, the efficiency of the four-wire current source active power filter can be improved to be close to the efficiency of the voltage source topologies. Nevertheless, all things considered, the voltage source topologies are found to be the most suitable for four-wire active power filtering.
Copyright: This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.


text:
But it did make me think. About a lot of things. I was glad my mind wasn't somewhere else and that I wasn't distracted with my phone or CD player.
My hubby stayed home today.
I definitely have super-woman syndrome, but it's not because I feel like I have to wear a cape. It's because I want to do these things like bake cookies and give a zillion percent of myself to everyone and every thing. It really does make my heart happy.
There's just so much that a human body can do. I get that.
(ducking) I did make 10 dozen cookies today.
But now I'm resting. It's a good thing. It's replenishing.
And just might be the only way I can have more of myself to give.
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