text:
ASICS GEL-Equation 5 Running Shoe - Womens
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December 11, 2013
What I expect from Asics
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November 04, 2013
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Proposed modifications to public participation in Allentown City Council meetings spurred a lively and sometimes angry discussion during a council committee meeting Monday evening in a fifth floor conference room in City Hall.
With one minor change, council's rules, intergovernmental relations and strategy committee is recommending that the full council approve a resolution containing the changes when it meets Wednesday night.
One contentious change in the proposed resolution would ask people to sign in with their name and address to speak at council meetings, but would not restrict those who do not sign in. Currently no one signs in.
Another change would allow the public to make Power Point presentations at council meetings, but people would be limited to three minutes and required to submit those presentations several days in advance for review. Hard copies of those Power Points also would be required.
The resolution also would allow public comment on proposed ordinances and resolutions when they first are introduced to council.
In the past, council did not allow comment when they first were introduced; they were assigned to committees with no discussion by council members.
And council will consider requiring that remarks made by the public at meetings should be addressed to council, not the audience. That recommendation is in response to a resident recently turning his back on council when standing before it.
All the proposed changes were approved by Julio Guridy, who is president of council and chairman of the committee, and by committee member Cynthia Mota.
Council vice president Ray O'Connell, who also serves on that committee, was absent.
The two committee members were willing to compromise only on how far in advance Power Point presentations must be submitted to the city clerk's office for review.
It originally was proposed as eight days, but Guridy was willing to reduce that to a Friday or Monday before a Wednesday council meeting.
"We didn't even allow Power Points before," he said. Council has allowed a couple of them within the last year, but at least one went well over three minutes.
Only a few residents attended the committee meeting, including three who regularly attend City Council meetings and frequently question and criticize council and the city administration.
Rich Fegley, the most combative of those critics, claimed "council is basically saying 'we want to stop all public discourse'."
Said Guridy: "We give people more time and opportunity to speak than many other municipalities."
Former City Council member Michael Donovan recommended that City Council delay action on some of the changes. He said people already don't feel confident that council listens to them. "If you move on these rules, it could just exacerbate things further."
Responded Guridy: "I don't think the public has a problem with it. Five or six of you have a problem with it."
On May 7, Fegley stood at the podium before City Council, but abruptly turned his back on council members and faced the public while he was talking. He said council was not respecting what he had to say.
On Monday, Guridy called that behavior uncivilized and disrespectful. "You know that's not the way we run the meetings," he told Fegley.
Fegley accused Guridy of creating a battlefield, saying: "If you're going to be disrespectful, we can do that too." Fegley even objected to Guridy referring to some of the men sitting around the conference room table as "you guys." He said Guridy should call them "gentlemen."
Resident Tom Hahn accused Guridy of filibustering.
Hahn complained that too many questions asked by the public go to the "I'll-get-back-to-you committee." He said Guridy never answers his emails.
Seeking more civility
Guridy agreed with Donovan that the overall objective of the proposed changes is "to have proper civic deliberation with a certain amount of decorum."
Guridy often advises the people in the audience at council meetings to conduct themselves as if they were in a courtroom.

subset: commoncrawl


text:
Top Definition
Noun - luh-ROY-yah - The state or condition of being broken. Especially in reference to the rear driver's side door of a black Ford Escape owned by Denis DEE-nis.
Fuque, the wind is whistling up in this door. Someone needs to fix Laroyja, again.
โดย Chewie Black 02 มกราคม 2009
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text:
Tuesday, July 9, 2013
Dear Editor,
I was astounded when I took my grandsons to play on the Doty Park playground equipment on July 4th.
While we hadn't had any rain before noon, I was flabbergasted to see the swings surrounded by a lake;
even stepping into the area, our feet sank into the wood chips!!
It only took me a split second to realize that the brick retaining wall surrounding the playground had no weep holes!
Was it the architect, Parks & Recreation project manager, or brick mason who failed to consider the effect a solid wall would have?
Hopefully, someone with a scintilla of sense will go to Doty Park and drill several weep holes at the bottom of the walls.
Frank Freeman
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text:
Wall Street Decline Takes Its Toll...
As Immunotherapy Revolutionizes the Cancer Treatment...
LC-MS Gains Favor Due To the...
Developers of DTC Genetic Testing Are...
BD Diagnostics and Biodiversity will work together on a molecular diagnostic menu for immunocompromised patients based on on the BD Max™ system. Tests will be designed to improve monitoring of infections in transplant patients and will be developed initially for the European market.
Biodiversity will be in charge of developing the assays, which are expected to expand testing capabilities for molecular laboratories with the ability to run many different assays and samples simultaneously. "With molecular testing established as the standard of care for managing transplant patients, the BD Max system will allow testing to be conducted with a standardized and fully automated workflow," says Giovanni Mantero, CEO, Biodiversity.
Tom Polen, president, BD Diagnostics—Diagnostic Systems, adds, "This collaboration combines the BD Max system's advanced automation and open system capabilities with Biodiversity's broad portfolio and track record at bringing to market molecular assays for the management of transplant patients. This will empower laboratories with a new choice to improve the efficiency, accuracy, and speed to diagnose these types of infections."
The BD Max system for molecular testing uses microfluidics and molecular biology to fully automate nucleic acid extraction and recovery, PCR setup, amplification, and detection. Today's arrangement is part of BD's strategy to bring new assays to the BD Max system in a range of diseases. With the agreement with Biodiversity, there are now more than 15 assays in the BD Max system's pipeline, the firm reports.
BD has been inking agreements to expand the BD Max system, including deals with Lonza, Diagenode, and Lab21. In October 2010, Lonza was brought on through an exclusive licensing and collaboration deal to commercialize the its microCompass™ molecular assays on the BD Max system. The firms are also collaborating on the development and optimization of what they claim will be rapid, automated, and easy-to-use microbial testing solutions that allow "load and walk away" operation.
In May 2011, BD reported a collaboration with in vitro diagnostic specialist Diagenode on the development of seven CE-marked molecular diagnostic tests for BD Max system. Diagenode will lead initial development of the assays including a respiratory panel, two panels for diagnosing virus- and parasite-based gastrointestinal infections, and a panel for the differential diagnosis of meningitis. Additionally, earlier this month BD said it was partnering with Lab21 to develop a molecular diagnostic assay for detecting Aspergillus fungal infections.
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text:
Top Definition
long, hard, rough sex...hard tingling humps...makes u horny.
Freeno me Im so horny!
от Jelissa 25 септември 2003
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Can you define these popular missing words?
The act of playing the casino game keno for no money, thus neither winning (or losing) any cash while playing such a lousy game
While waiting for our breakfasts in the coffee shop at Binions, we played freeno to pass the time.
от amace020 09 март 2009


text:
Topic: The tragic end to Romeo and Juliet was the result of fate rather than their own actions.
Many people would say the play is about two star-crossed lovers that, because of fate, will never be together. Others would disagree. There were many tiny actions that could have prevented their double suicide in the end – the letter being delivered, Juliet waking up slightly earlier, Romeo arriving thirty seconds later etc. – that make this story quite taunting to the reader, especially if read numerous times. If it were fate that controlled the outcome, then there would not have been so many opportunities to prevent the double suicide.
One such 'opportunity' was the drinking of the potion by Juliet. If she had drunk the potion perhaps thirty seconds earlier, she would have woken up thirty seconds earlier and Romeo would have arrived after her awakening. However, this did not happen, and Juliet awoke too late for her love to see that she was actually alive, and not dead, as he'd thought (act 5, scene 3).
If everything that happened in the play was due to fate, then everything that happened would have a reason, would it not? Well then, what is the reason for Mercutio's death? The feud was between the Capulets and the Montagues, and Mercutio was part of neither family. Mercutio had nothing to do with the feud, and yet he was murdered. His final words are particularly moving – "A plague o' both your houses" (act 3, scene 1) – as they are condemning both families (Capulet and Montague) because of the feud that ended his life. It was the actions of Tybalt that killed Mercutio, not fate.
There is no doubt that fate plays a huge role in the story of Romeo and Juliet; however, their death could have been avoided if certain people took control of their lives and chose their own actions, rather than believing that fate had set everything out and there was nothing they could do about it – an example of which is shown in act 3, scene 1, line 41 – 'Can heaven be so envious?'. Here, Juliet is wondering aloud whether fate really is so cruel as to kill her cousin, Tybalt. This is a perfect example of the characters believing that everything was down to fate.
At the beginning of the play, the prologue acts as the story teller, essentially telling the story not of Romeo and Juliet, but of their fate. With the words 'From forth the fatal loins of these two foes/A pair of star-crossed lovers take their life', the prologue is saying that the ultimate fate of these two lovers from opposing families (Romeo and Juliet) will end with their death – as if this had already been laid out by fate. However, as was earlier stated, their eventual suicide could have been avoided by a few simple actions, many of which had opportunity to do so – Juliet could have taken the potion earlier, Romeo could have received the letter on time, Mercutio and Benvolio could have left the street (thus preventing their meeting with Tybalt, and then Mercutio's death, thereby removing Romeo of his motive to murder Tybalt (and he would not have been exiled to Mantua)). Many different things could have prevented their death, and there were many opportunities to do so. If the characters of the play had not believed that everything was due to fate, then their actions may have been different, and could possibly have prevented Romeo and Juliet's deaths. Therefore, fate does play a large role in the eventual double suicide, but a few simple actions could have prevented it, proving that one's actions play an even larger part.
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text: A staple tool for any bee keeper, the bee brush is used during basic management, inspection, honey harvest or during transfer of comb from one hive to another. (We recommend you use your brush sparingly, as they have the potential to injure or irritate the bees!) This brush can be washed should it become covered with honey or propolis.


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Driver: San Francisco for Xbox 360On: Xbox 360, PS3, PC, 3DS, Wii
Tanner is back, but he's in a coma and can shift between the bodies of people in the city.
Stuck on Driver: San Francisco? We've got you covered!
Don't panic! Our cheats will see you through.
UK Video Game Chart: Dead Island eats rivals' brains
Deep Silver and Techland's Dead Island has entered the UK All Prices All Formats chart at No. 1, beating off competition from Space Marine, Driver: San Francisco, Resistance 3 and Deus Ex.
Free multiplayer content for Driver: San Francisco
Driver: San Francisco will receive free multiplayer content and a community service, Ubisoft has announced.
Ubisoft scraps Uplay Passport for Driver: San Francisco
Publisher forced to offer online for free after an error printing the access codes.
Win Driver San Francisco goodies
Win one of five copies of the game as well as a cool Driver jacket, all by answering an incredibly easy question.
UK Video Game Chart: Deus Ex stalls Driver comeback
Square Enix is celebrating a second week at the top of the All Formats All Prices UK video game chart, despite a 46 per cent drop in sales over its debut week.
The VideoGamer.com Podcast: Episode 10
We've reached the tenth episode of the VideoGamer.com Podcast, huzzar! Not only that, but gaming's notorious summer drought is over!
Heads-up: New games out this week
Every Monday we'll pick out the best of the bunch, link to our reviews and previews and keep you in the video game loop so you have enough time to pre-order for Friday's post.
VideoGamer.com Plays
This week it's Driver San Francisco, Deus Ex: Human Revolution, StarCraft II and Terraria.
Driver San Francisco multiplayer demo due August 17
Ubisoft has announced that a multiplayer demo for Driver San Francisco will arrive for Xbox 360 and PlayStation 3 tomorrow, August 17.
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text:
He Blinded Me With Science
If your body pH is alkaline, you can not get cancer. ... If itís acid, you can get cancer. In ourómy personal observations, every single person who has cancer has an acidic body, acid pH.with
-Kevin Trudeau, from the infomercial designed to sell the book Natural Cures "They" Don't Want You to Know About
There was only one guy in the history of baseball who could pitch every day without discomfort, and that was me. People said I was a freak, but it was how I threw. Give me Kerry Wood and Mark Prior and, after I train them, they will be unhittable forever. Nobody will worry how many pitches they throw. ... [Larry Rothschild and Tom House]sure as heck don't know how to apply Newton's first, second and third laws to the pitching motion. They don't know Isaac Newton from the Fig Newton.The Daily Southtown's Paul Ladewski wrote a doe-eyed piece about Mike Marshall and his criticisms of Mark Prior's pitching mechanics. With all the hemming and hawing about Prior's health, it's irresponsible articles like this one where we need to keep our sense of perspective and skepticism. Read the article for yourself, but in case you choose not to, here's my synopsis:
-Mike Marshall, Ph.D. (first quotation from 6/24/05 Tribune, second from article linked below)
1. Paul wants to trade Prior for Tejada. 2. Because Prior gets hurt and Tejada doesn't. 3. Mike Marshall knows how to correct Prior's mechanics so he doesn't get hurt. 4. The fact that Mike Marshall has virtually been blacklisted by major league organizations and that he knows Newton's Laws means he MUST be right!For all we know, Marshall might be right when he says there's a loop in Prior's motion. For all we know, Marshall might really have the secret to building every pitcher in his rubber-armed image, and there just isn't a single major league organization smart enough and bold enough to hire him and it's just a fluke that not one of his students has made it in the majors. But knowing Newton's laws of motion doesn't mean *#$% when it comes to building a better pitcher, and Marshall keeps pretending that it does in order to pass off his (currently) fringe, unaccepted theories as scientifically legitimate. Everyone, EVERYONE associated with the act of throwing a baseball understands that the trick is to apply the most force in the most efficient manner possible, and that a loss of efficiency requires the pitcher to exert more force in order to get the same effect, increasing the risk of injury. Whether or not Rothschild and House can name the three laws that first correctly described the relationship between force, mass and accelleration (in an idealized and pre-Einsteinian universe) is completely irrelevant to the issue of whether they can do more for Prior than Marshall could. And what about Marshall's claims that he could pitch every day, as demonstrated by his famous 1974 season, in which he appeared in 106 games and pitched 208 and 1/3 innings? The effects lingered, as he pitched in 57, 54 and 16 games the next three years. I'm sure Marshall's forgotten more about pitching mechanics and physiology than I will ever know. And I've been a bit unfair comparing him to Trudeau - the one mis-represents real science to sell his dubious theories, the other invents fake science to sell his patently absurd theories. But ultimately, we do not yet have one shred of evidence to suggest that Marshall's theories actually do build better pitchers. And in lieu of such evidence, an ignorant reporter with an ax to grind against Hendry, Baker and evidently Prior, lets Marshall spout off self-aggrandizing, scientific-sounding mumbo jumbo that does nothing to clear up the issues surrounding Prior, House, Rothschild, Baker, Hendry, or this insufferable trade talk.
mike marshall can also walk
mike marshall can also walk on water.
he teaches kids in his "camps" in florida for $10 a day. that's about what his instruction is worth.
seriously, if he didnt believe the only way is the mike-marshall-way...he might be working for a pro club as a pitching coaching making more a year than his playing days.
First of all, Marshall was
First of all, Marshall was blackballed for being pro-union, in a more extreme way, and major league clubs knew that signing him would cost them more than just his salary. I'm convinced that he, like Flood, could have played longer had they kept their mouths shut. He pitched in Semi-pro leagues for years after he retired from the MLB, which means his arm couldn't have hurt that bad.
And there IS a flaw in Wood's delivery, and probably Prior's. Whether or not Marshall can fix it is another thing.
He doesn't say if he's had any students make it to the majors; he claims he does, but also claims he does not want to take credit for their success. Maybe he has, maybe he hasn't, but you don't have the proof that he hasn't.
He may not be as great as he says he is, but Rothschild hasn't quite been the best at keeping our pitching staff intact, and House's pitchers, including his son, have been injury prone.
Marshall may be a quack, or he may be on to something. Jim Bouton spoke highly of him in Ball Four, and that was before he became anything. I wouldn't put it past him to have come up with a better way to pitch, or the baseball institution to completely ignore it, given their acceptance of new ideas... but until he proves it he shouldn't think as highly of himself as he does.
Transmission: Amen! I am
Transmission: Amen! I am so sick-and-GD-tired of Marshall shooting his mouth off.
Two responses: 1. Thanks
Two responses:
1. Thanks for pointing out that he was blacklisted over union matters. But if you read the article, Ladewski says "who has been blackballed by the big leagues because he has a lot of goofy ideas and isn't afraid to speak his mind."
That isn't playing to the idea of Marshall being blackballed for union matters, it's playing to the idea of Marshall as an unrecognized genius, a radical who is ahead of his time. If Marshall's blacklisting has nothing to do with his pitching theories, then Ladewski's piece becomes even more responsible for suggesting it does.
Second,"you don't have the proof that he hasn't."
True, but it's not my burden of proof, it's his. If he doesn't want to take credit for all the anonymous pitchers who have found success in the major leagues, that's his prerogative. What you're asking is that I prove a negative, that I prove the absence of his success. That's impossible. The best I, or anyone can do, is look at every single pitcher who has pitched in MLB, and note that none of them have success they credit to Marshall. If Marshall wants to present something to oppose this complete lack of evidence, he's the one that needs to do it - how would I?
"Ladewski's piece becomes
"Ladewski's piece becomes even more responsible" should be "Ladewski's piece becomes even more IRresponsible".
I suspect you already figured that out, though.
Really, if Kiniack is right and the blacklisting has nothing to do with Marshall's views on pitching, then Ladewski is flat-out deceiving readers for the purpose of building up Marshall's status as a brilliant scientific renegade.
Kiniack = Kinanick, even.
Kiniack = Kinanick, even. I'll go do something else, now.
Sheesh, it's a palindrome
Sheesh, it's a palindrome :-p Kinanik kinaniK
Wow, that's right, even my
Wow, that's right, even my CORRECTION got it wrong.
I am the idiot savant of TCR. What can I say? ~grin~.
My apologies, Kinanik, and a ~fwap~ up the side of your head for creating a name that exposes my disease: Harry Carayitis.
Now, back to the topic....
OK, back to the
OK, back to the subject...
There are pitchers who can throw an inordanite number of pitches, and I don't think that Livan Hernandez, Nolan Ryan and crew are all genetic anomolies (Randy Johnson might be). If they're not anomolies, then there are only a limited number of reasons they can throw so many pitches without hurting their arm, luck, work distribution and mechanics. If Marshall was indeed one of these people who could pitch alot and not get hurt, maybe he should be listened to. If he was hurt, then it doesn't look like he was on to anything. If he was spared injury due to his own pitch management, and innings management by his managers, we can learn from that too.
I do think that there is too much coddling of pitchers in many cases, and not enough with others. There's no reason a 22 year old Prior or Zambrano should throw 141 pitches in a game, but a 26 year old Prior or Zambrano, with no injury history, shouldn't be treated like a kid.
I think I agree with
I think I agree with everything in that post, K.
I would say that while I do not know if Marshall was outright hurt, just fatigued, or just used less in the three years following his 109 appearance year, the evidence seems to suggest that he WASN'T as durable over the long term as he claims. (Who COULD be as durable as he claims - he says that he never ever felt fatigued and could pitch every single day. That first quotation of his is just absurd.)
So I think everything you say there makes perfect sense. I also think Marshall is trying to position himself as the Pied Piper - the mysterious, outsider guru who has all the answers. Once in a long while, they may be right. But most of the time, they're either cons or they're delusional. And when I look at Marshall's claims about his own career, compared to reality, and when I look at the ways he is using his scientific training and his Ph.D. - to pointlessly browbeat people without scientific training or letters, instead of to enlighten - I conclude he's more likely a con or delusional.
I don't necessarily want to trust Prior's arm to Rothschild and House, but I darn well am not going to turn his arm over to a guy that seems to relish sounding like a quack.....
Exactly, I wouldn't send
Exactly, I wouldn't send Prior to one of his camps, but if he wants to diagnose a flaw in his mechanics he has at least enough credibility that Rothschild, or the trainers, should check to see if there's any truth to his claims. Especially if it's for free.
Einstein was a percived
Einstein was a percived quack and kicked out of mainstream schools as a child.
Anybody glad you have heat from electricity if you live above the Mason Dixon line?
Point is....how the hell do any of you know...correction...how the hell do any of us know...if Marshall is right or nuts?
Second point is....why does it matter if nobody in MLB listens? Get on a real topic...AZ Phil..start something smart again, please.
Joey from Newton.........freezing my ass off with X's mongoloid cat that wandered over....name of Earl (pay attention, the name WILL come up again). X, the wife doing okay?
OOPS...percived=perceived. J
I do not want to defend
I do not want to defend Marshall, who seems like a self-promoting crank to me. The main result of the article will no doubt there being a number of new "students" from the Chicago area whose parents will "insist" that their son absolutely, positively "must" go to Marshall's school this next spring break.
But I did peruse his web page today after seeing the article. Some of his advice for youngsters seems sound -- principally his recommendations that boys under 13 should NOT face live batters or even try and throw hard more than twice a week. He has a lot of criticism for Little League Baseball for having high mounds at younger ages, etc.
While Marshall does seem like a crank, I do think that for some inexplicable reason, baseball severely undervalues good pitching coaching. Leo Mazzone routinely made $5M pitchers perform at $10M levels -- and he got paid not even $1M by the Braves. Ray Miller made Bruce Chen a serviceable starter last year...and was effectively told to retire. I don't understand this blind spot because a good pitching coach can pay his salary many times over simply with one or two successful students. Marshall may be a paranoid crank, but with many paranoids, there is a kernel of truth.
Joey - The myth about
Joey - The myth about einstein being a quack who was bad at math and kicked out of regular schools is just that. A myth. We LOVE to mythologize the geniuses so that they sound more like us - misunderstood people struggling from day to day. And certainly, they had their struggles. But neither Einstein nor Edison fit that mold.
I also agree with everything
I also agree with everything DC TOM says. Marshall's heart is probably in the right spot, where his little league critique is concerned.
by all means, boys under 13
by all means, boys under 13 should not be facing live batters. That sounds fun. Should really pique interest in the sport. :)
I suppose he means the legit athletes who have a future, but how do you really know that at age 13?
I do recall him saying that he doesn't think a young pitcher should throw a breaking ball until after age 18. Probably a good idea, but once again, good luck convincing a kid not too. I think I spent most of my downtime in baseball trying to throw curveballs.
I suppose if I was a high school coach, I'd certainly encourage my pitchers to throw just fastballs and changeups and rely on location, but theory doesn't always hold up to reality.
i cant really watch the LL
i cant really watch the LL world series anymore cuz there's always one coach (lately, and horrifically more) that has a kid that will throw a slider or some sliding/curve pitch after pitch after pitch.
seriously, gimmie a youth coach that will throw a kid 100 pitches with almost exclusively his fastball over a coach who will let a kid throw 50+ moving breaking pitches a game just for the sake of winning.
i dont have kids, nor do i live in a highly competitive youth baseball area, but a lot of the more competitive youth baseball programs out there are pushing the breaking pitch to the point of obsurdity...at least judging by what i keep seeing on espn.
Will Carroll wrote an
Will Carroll wrote an interesting piece at BP today in response to the recent Mike Marshall article.
He points out that unlike other, non-blacklisted pitching experts, Marshall cannot point to any of his deciples as MLB sucess stories.
He's careful not to throw out the baby with the bathwater, but he argues against most of the points raised by the "doctor" in the daily southtown article.
Most interesting to me was Carroll's point that there is probably nothing wrong with this "loop."
"...[The loop] Marshall is describing is what a biomechanist would call external rotation...the action is standard. The work of both American and Japanese biomechanists, using both standard and double-spin mechanics, show that this motion does not create undue force."
Here's a few more snippets from today's under the knife colum at baseballprospectus.com. It's a good read.
"Simply put, Mike Marshall knows what he's talking about, yet is the wrong messenger for getting that message out..... His continual attacks and refusal to be measured by any reasonable standard undermine any good that he could have had....His refusal to adjust, integrate, simplify and modify likely leaves the good parts of his work on the shelf--like far too many pitchers."
yeah, that article was BS,
yeah, that article was BS, I'm glad you's guys pointed it out.
Why hven't the Cubs looked
Why hven't the Cubs looked to Fergie Jenkins. Whenever I hear him talk, I'm amazed. Maybe he should not be a pitching coach, but an advisor. Someone like him could end a team's treating their pitchers like they wer made of glass
I have nothing against Will
I have nothing against Will Carrol, but didn't he publish a book about pitching? It wouldn't really be in his best interests to say 'Mike Marshall's a genius, use my book as a coaster' now would it?
I don't think that
I don't think that Rothschild or House knowing nothing about Physics is any issue about their pitching knowledge. I mean Indycar drivers probably don't know the physics or engineering behind building a sportscar engine, but they can surely drive those things really well.
However, when you do look at the track record of Larry with the Cubs, he doesnt look to be a very effective pitching coach anymore.
Fergie had a one year stint
Fergie had a one year stint as Cubs' pitching coach and wasn't rehired.
RE: 15 FWIW, I think a more
FWIW, I think a more analogous scientist would be Einstienís predecessor Georg Riemann, who developed the coordinate system which Einstienís general relativity is based on. Riemannís genius was recognized by very few mathematicians at the time though he still was recognized as a competent scientist. It wasnít until after his death that Einstein showed the scientific community the significance of what he had done.
Although it seems that Riemann wasnít the vocal advocate of his own work that Marshall is of his.
Amen Trans! I'm sick of bad
Amen Trans! I'm sick of bad journalists giving people like Marshall a forum.
Mike Marshall is the one with the radical claims - he should prove it! It doesn't work the other way around.
Somebody has pointed out that Edison not Einstein "invented" electricity right?
Oh and Kinanik let's not forget how House got famous in the first place. It was teaching Nolan Ryan.
What about the tolerance for
What about the tolerance for pain factor? IE: Test tube athlete running to the doctor for an evaluation of a hangnail. Doc's evaluation including the word "inflammed", which takes said test tube athlete out of the game mentally, more so than physically.
Until I see Wood and Prior
Until I see Wood and Prior prove that they have the ability to take the ball every 5th day, I will choose to believe that Marshall (and Stone) are right on their assessment of him. Groin, arm, elbow, whatever else has bothered him the past few years...that's enough for me.
We are doing something wrong in how we manage and train pitchers. I'm not smart enough to know what it is - but what we are doing isn't working.
If you distribute the pain
If you distribute the pain that Roy Oswalt has pitched through over the past 3 years, evenly, to each of the Cubs pitchers, we would have to forfeit each of those seasons.
I vote the Cubs ship Koronka
I vote the Cubs ship Koronka to Marshall in a large pet carrier with return postage and some Combos for the journey. What have they (or Koronka) to lose?
Wood clearly has an acidic
Wood clearly has an acidic shoulder.
Transmission.....actually it
Transmission.....actually it is a fact that Einstein was "an odd duck" and not able to stay in mainstream schools. I have no idea about Edison....and why the hell do I/we care anyway? I get nuts over this stuff, that's why.
Now... the fact is that me and Earl (X's mongoloid cat) were hitting the Irish Coffe too hard when I wrote that ugliness....and did indeed cross my genius misfits......which reflects poorly on us cornfed boys in Iowa.
Sorry guys....my cuteness backfired.....but I was in fact trying to make a point with a story.
I'll suck my thumb and curl up in the fetal position in the corner for awhile. And for those who take my garbage literally and argue for arguement's sake, I'M BEING FACETIOUS....I LIVE IN A ROUND HOUSE WITH NO CORNERS, SO I CAN'T LAY IN A CORNER...GEEEEEEEEEEEEEEEEEEEEEEZZZZZ!
House may have taught Nolan
House may have taught Nolan Ryan, but he started coaching him in 1980, and Ryan's numbers before and after that are very similar. Ryan had been throwing a huge number of pitches before being instructed by House, and would continue to afterwards.
Mechanics aren't instantly
Mechanics aren't instantly fixable, either. Successful and durable pitchers do NOT all look the same. Try comparing Greg Maddux's mechanics with Nolan Ryan's, I really don't think they're gonna be identical. Biomechanics are tailored to the individual and are not for mass reproduction because they are unique to a person's build, proportions and experience. Anyone that thinks they have a perfect (and theoretical) biomechanical model that can apply to any pitcher is making stuff up. Basically, because it worked for Mike Marshall does not mean it will work for Mark Prior or anyone else.
Yes it's true that the same
Yes it's true that the same biomechanical solution doesn't always work for everybody and it's quite obvious since no two people have identical bodies (no not even "identical" twins). I believe though the point that was mentioned by Marshall in the article is that Prior is doing something WRONG biomechanically that was causing stress on his arm.
The wrong movement is something that is more universal in that it is probably the wrong movement for almost every pitcher. For example, if you bend your fingers backwards far enough then it's going to hurt. It doesn't matter that every person's hand is shaped differently, if you bend the fingers backward then it will hurt.
So the flaw in Prior's delivery will probably be a flaw also in most other pitchers. The differences will come in HOW TO CORRECT the flaw's since no two bodies are the same.
I did not give the article a
I did not give the article a great deal of weight since this is old news. This stuff about a loop in Wood/Prior delivery has been discussed before. However, Trans I think your ability to frame an argument about Marshall is a bit weak. You basically say that Marshall may know what he is talking about and you don't know as much as Marshall about pitching but you beleive he is a quack so we should't believe what Marshall has to say. Personally as a Cub fan I would hope the Cubs do anything they can to make sure Wood and Prior can pitch at least 200 ininngs this year. If it means listening to a "quack" I am all for it since nothing else seems to be working.
Recent comments
doh, yes...dunno what happened there. jake arrieta is all "bro wut?"
lester going for #20...cubs haven't had a LH (thanks jpep for the correction) 20 game winner since d.ellsworth in 1963.
fwiw, all the games are free on mlb.tv
Short rest for MadBum would be 2 days. WC game is Wed., Games 1 & 2 are Friday/Saturday.
A left-handed one...
J-Hey not finishing with an offensive onslaught.
If Geoff Blum could be a Playoff hero, there is hope still...
Giants scare me. I think you're wrong about Bumgarner, he would pitch on short rest for Game 2 and then full rest for Game 5. Cueto would go Game 1, then short rest in game 4. Add in some really tough outs in that lineup and I want nothing to do with them. With that rotation they can easily steal a series.
Cards are a tough matchup. The rivalry evens out their comparable lack of talent. And like someone said, they love HRs, which is how to beat the Cubs. The upside is that I would feel really good about Lester twice against STL.
j.buchanan with a nice start...5ip 2h 1bb 3k, 0r/er
zobrist with 2HR and a double through 8
heyward 0-4 :(
Mark Gonzales @MDGonzales
Soler likely to return Sunday, Maddon says
Right now, I'd like to see the Mets first, Giants 2nd.
I believe that since most of the team from last years' NLCS is on the squad this year, they will really amp their game up even more to kick their ass in payback for 2015.
The Giants just do not have the depth in years past, and I think all things equal - and at Wrigley - they could handle them.
I do not want to see the Cards, period. Or their fans, media, or Joe Buck.
I don't want to play Braves in the first round. Any friggin team in the league can win 3 of 5..I hate the first round. Furthermore, I wanted to play the Marlins in 2003 and the Mets over Dodgers last year.
With that said in reverse order:
3. Cardinals: It will be devastating to lose in the first round, but even worse to their main rival. It is increased incentive for the Cardinals, especially after last year. Cards would have nothing to lose, Cubs have everything to lose.
2. Giants: Rotation in the playoffs scare me a bit, but what a lousy team.
1. Mets--because of the losses in the rotation
2. Giants--because they're not the team they were BUT they maybe have bullshit even-year magic?
3. Cardinals--because rivalry and not making the playoffs hurts them more than losing in the NLDS plus getting eliminated by them in the playoffs would make for horrible sports commentary next throughout next season.
Who's asking?
CLE/DET rained out last night already, possible rain-outs in New York (vs. Baltimore), Boston(vs. Toronto) and Philly(vs. Mets) this weekend too.
Not only games involving playoff spots that would need to be played, but any that involve home field advantage.
I got the first one! Second one I'm not even sure what even/odd betting is.
any opponent preference for NLDS?
Mets are down to 1 great pitcher instead of 4. Syndegaard may pitch Sunday which means if Mets win the WC game, he'd be set up for Game 1. There's a chance they clinch a spot by Sunday so he'd pitch the WC and then we'd probably get Colon for Game 1. They've certainly had the hottest bats over the last week and month out of the WC options.


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In 1995 Greg Zeschuk and Ray Muzyka had two passions: medicine and role-playing games. If the two young doctors weren't tending to Alberta's sick they were playing table-top adventures or talking about translating them into video games. When they co-founded BioWare with fellow doctor Augustine Yip, medicine still represented Muzyka and Zeschuk's day jobs as they tried to balance their passions.
Four years later, with the aid of publisher Interplay's D&D license, the doctors made the second best-selling PC game of 1998 - Baldur's Gate, universally hailed as a seamless marriage of D&D mechanics and interactive storytelling. BioWare was now a close-knit 65-man studio, its halls lined with prototype sketches of fantasy worlds to come. For all the success, Muzyka and Zeschuk remained humble. They still practised medicine when they could. Neither saw BioWare ever completely taking over their lives.
Today BioWare has roughly 800 employees across six studios. Each studio ultimately reports to Muzyka, while Zeschuk is in charge of BioWare Austin and responsible for The Old Republic. As for medicine, that balancing act is over. There hasn't been time for it in roughly a decade.
But some fans now believe the doctors struggle with a whole new balancing act, that of EA and BioWare. When EA put up $860 million to acquire BioWare/Pandemic from VG Holding Corp in January 2008, public cynicism wasn't so heavy. The publisher had worked hard to lessen its reputation of chewing up small studios for easy bucks. Brand new IPs like Dead Space and Mirror's Edge had sparked interest while partnerships with Valve and Crytek cemented a seeming shift in mindset. But there were still cynics.
Dan Fedor worked at BioWare for seven years and was one of the 300 or so employed during the EA buyout. "Day-to-day work proceeded pretty much as it always had," Fedor recalls – he was a lead technical artist on Dragon Age: Origins at the time.
"I'd say the most obvious changes I can recall were actually positive ones: improved compensation for employees, and improved infrastructure. EA made it a point to standardise compensation across its studios, and for BioWare that actually meant bringing many developers' compensation packages up. And EA's vast size meant we had its many resources at our disposal, including localization, QA, and several technology initiatives for improving workflows."
There was, inevitably, tension.
"I can't deny that many employees were fearful at the announcement of the merger. Many of us expected EA would drastically change the culture at BioWare. As time passed, though, it became clear that what EA wanted was for BioWare to keep being BioWare. Despite popular bombast, no storm troopers breached our airlocks and started imposing martial law."
Drew Karpyshyn recently announced that he's leaving BioWare to concentrate on his novels. During his 12 years at the studio, Karpyshyn served as lead writer for Knights of the Old Republic and Mass Effect, among others. Like Fedor, he says that the EA buyout brought few significant changes in day-to-day operations.
"EA really wanted to let BioWare do what it does best, so they were smart enough not to try and change things that were already working," he agrees.
"They did give us more resources - bigger budgets, more advertising support, a greater presence at various conventions and expos, the ability to open studios in Austin and Montreal so we could work on multiple titles effectively - but beyond that BioWare was still BioWare."
Fedor's work at BioWare included both Dragon Age games. While the first received great acclaim from fans and critics, Dragon Age II notoriously prompted a huge backlash from disillusioned BioWare fans through low Metacritic user scores, many of which were posted before the game was even released.
Most user reviews lambasted the game's "aerodynamic" design as patronisingly dumbed-down, especially for a game in a series billed as the spiritual successor to Baldur's Gate, and the blame was laid firmly at EA's doorstep. EA's reputation for acquiring talented independent studios like Westwood and Bullfrog and burying them dead had come back to haunt them, and fans weren't assuaged by EA CEO John Riccitiello's assurances that this time it was different.
One fan posted on the BioWare forums that the developer had "sold their soul to the EA devil", only to have his account locked and access to Dragon Age II taken away for 72 hours. While the ban was later revoked by EA, some fans began to feel betrayed.
"I can understand where fans are coming from, but I don't think EA are the meddlesome overlords that many are making them out to be," says Fedor "EA just make a convenient target. Sure, EA has had some black eyes in the past, and probably deserved some of them, but I never got the sense they were forcing us to do things we didn't want to do."
Fedor left BioWare this time last year, taking the decision to give up his salary and move into the risky world of indie development. He's close to releasing his first solo title, N.E.O. Scavenger – predictably an RPG, albeit one that mixes Civ-like turn-based play with post-apocalyptic survival. Creating his own game has perhaps given him perspective on the difficulties of game development.
"BioWare makes decisions too, both at senior leadership and team levels. Even lucky idiots like me, frankly. And sometimes we make bad calls," he admits.
"Hi, I'm Dan Fedor, and if you wonder why players can't have cloaks in Dragon Age: Origins that was my fault. Sorry dudes, I couldn't make them work well enough. I screwed up. We all screw up, despite our best efforts."


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Courtesy of Studio &
Courtesy of Studio &
Revisionist history has become so commonplace in American classrooms that it�s now the norm. So it�s hard to find words to describe the alternate timeline that 30 artists dreamed up for �YEAR: A Brief Underview of the History of Time� at Studio &.
�We all were taught �this is the man who did this,� and we know about all the wars, but this is the grout in between those pillars of things we�ve been taught,� said Tim Kapustka, a founding member of the Main Avenue arts collective, in a group interview on The Four Corners Arts Forum on KDUR-FM.
The & crowd, each of whom also has contributed to �YEAR,� invited artists to choose a year and create a piece of art to reflect their interpretation of that time. The works will be displayed in chronological order for tonight�s show.
�It�s part of the creative process, and we�ll figure out how to show it,� Kapustka said.
There are no limitations to what can be done. Kapustka said he doesn�t know what the exhibit will look like. Artists had until Thursday afternoon to submit their pieces, and the show will be arranged for display on the fly. Not all of the art will be visual; Shay Lopez and Minna Jain plan to immerse themselves in the exhibit with performance art. Jain chose the year 2064 for her multimedia presentation.
�I�m inspired by ideas of time and place and how they inform us,� Jain said. �I love science fiction and fantasy, how the stories can resonate. I�m wanting to not break down 2064 culturally or environmentally, but instead I wanted to make it more personal. This is the most fun I�ve had with a piece of art in a long time.�
There will be a lot to see, watch and read. Scott Dye�s small painting of a bird and ship comes with a title that is its own history lesson: �1835; in which a young Charles Darwin, aboard the HMS Beagle, lands on the Galapagos Islands and encounters the Blue-Footed Booby for the first time. That same year, Auguste Comte, a prominent French Philosopher, posits that humans will never be able to understand the chemical composition of stars but is subsequently proven wrong by astronomers embracing the recently developed technologies of spectroscopy and photography.�
Artist Elizabeth Somers opted for simplicity in form and presentation. Her take on 1960 is a minimalist sculpture that is a good example of why it will take time and attention to fully appreciate �YEAR� and not miss anything.
�I didn�t have to think twice,� Somers said. �Even 20 years ago I was intrigued by minimalism and more so now. We�re so inundated with information, and art�s like that. The more color or materials you add, you get caught up in it. So I did one simple piece, and I knew what I would do would blend in. Tim always comes up with something challenging and stimulating. Every so often, I get a little tired of art just hanging on the wall.�
STEVE LEWIS/Durango Herald
STEVE LEWIS/Durango Herald


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St. Peters, Mo. — After a state-wide call for nominations, the Missouri Department of Conservation (MDC) has selected a Colorado spruce (Picea pungens) in St. Peters to be the official Christmas tree at the Governor's mansion in Missouri's Capitol City. The tree will be cut Wednesday, Nov. 27, at 9 a.m.
The tree is located on the Carrera residence, 37 Jane Drive in St. Peters and was nominated for the honor by the Carreras. After removal, the tree will be professionally decorated and displayed in front of the Governor's mansion in Jefferson City. This will be an excellent opportunity to gather photos and video footage of the cutting.
It's a long-standing annual tradition for MDC to supply the official Christmas tree displayed in front of the Governor's mansion. Each fall, MDC issues a state-wide call for interested property and homeowners to nominate a tree from their property, perhaps one that needs to be removed for home expansion or utility work. The owner must be willing to donate the tree at no cost to the state or MDC. MDC Forestry staff reviews all entries and selects the winning tree. The tree is then removed at no charge to the owner and delivered to Jefferson City.
For additional information, or to arrange media interviews, please contact Dan Zarlenga at 636-300-1953, ext. 4112.


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Top Definition
The act of awesomerist; when something is beyond being described by ordinary words, or at all.
Dude 1: "Hey man, they are giving away ice cream cones, puppies, and $20 bills down the street! Hurry up!"
Dude 2: "That is just....like...AWESOMERISTISM!
Dude 2: "That is just....like...AWESOMERISTISM!
de Crispy Fried Death the III 17 Mai 2012
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Casa Moderno
Casa Moderno, founded by George Machado, is the newest Palm Springs emporium,
offering an artistic mix of 20th-century furnishings. This includes pieces from
vintage Palm Springs, Trousdale modern, and Hollywood Regency. Since the store opened in 2012, Casa Moderno's unique mix, curated by George, has become a favorite for interior designers and modernists alike.


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Are you interested in an internship in a fun and rewarding office environment? Join the Visit Mason City team for the summer where interns will gain hands-on experience in the marketing and business field by coordinating brochure publications; assisting with special promotions for community awareness and outside marketing initiatives; staffing the information center and assist with the coordination and execution of visitor center duties. For more infomation contact Sue Armour at 641-422-1663 or firstname.lastname@example.com
For more information: Waldorf University is a four-year liberal arts college offering 20 bachelor degree programs in a variety of popular fields both residential and online. For over a century, Waldorf has provided a signature student experience through an engaging community of learning and faith. That community has now expanded beyond the campus through Waldorf's distinct approach to online education. Waldorf's academic programs combine a strong liberal arts base with applied learning. Co-curricular programs ranging from the second oldest a capella choir in the nation, to an outstanding theatre program, to highly competitive athletic teams, provide students with a wide range of opportunities for meaningful participation in personal development. Waldorf is committed to engaging its students in service and in bringing the world to its students through international student recruitment and study-abroad programs. Every student is challenged to excel in Waldorf's community where students are treated with dignity and respect. The university has an attractive campus with 14 major buildings and excellent resources.
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When it comes to coffee, it's all about the buzz. We're talking about that rise-and-shine jolt from a strong cup of coffee, aromatic and warm against your hand�or chilled, that's cool too. What could be better? Dessert, you say? Well, we concede. The addition of coffee takes sweet desserts to new heights, offering the slightly bitter, yet earthy contrast of strong coffee flavor against traditionally sugary-sweet dessert ingredients. In honor of National Coffee Day�this year officially on September 29th�we're celebrating with a collection of 15 of our favorite coffee-infused dessert recipes from the Relish recipe archives. Plus, we're offering a bonus round-up of coffee cakes that are made without coffee, but will perfectly complement a cup or two, however you take it. Simply click from our list of recipes below, or scroll down for the host of our favorite coffee cake recipes.
Incredibly Good Coffee and Espresso-Infused Desserts Brought to you by: Relish
Location, ST | website.com


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Early education must be carefully monitored
May 5, 2013
Not so many years ago, school started with first grade for the overwhelming majority of childre....
WV making great strides? That is laughable. We still rank dead last in some polls for quality of education. We shouldn't even get a participant badge at this point. The school system is a horrible failure. Get rid of standardized testing and let teachers teach, instead of binding them to teach for the test.
0 Agrees | 1 Disagrees | Report Abuse »
The first encouraging education stats of any kind that I have seen since moving here 9 years ago. Keep it up WV!
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"youngster who has not been exposed to educational stimulation before that finds himself behind his classmates at that stage"
Major: "With all these Head Starts, Hands Out and Youre First programs how can anyone not be prepared?"
Ahem. Pardon? I didn't say anything; not a darn thing.
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education isn't the answer..sorry but the facts speak for themselved: we have MORE college grads today in the US than at anytime in history, yet, look at the condition of the country...education can't save us from ourselves, or our inate attitudes. More PhDs and MSs isn't the answer..... more belief in God's Word is the answer... it was when He walked the Earth, and it's still is THE answer today...your opinion doesn't matter to Him, either, BTW....so keep on trying to get kids to write and spell by the time they're 18 months...it won't help....
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@unknown. The parents need to be educated enough themselves to know their child needs some education. Personally, I would be happy if people would at least teach manners and verbal etiquette.
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When will the parents start stepping up and helping with their child's education. What I see in W.V. is the parents expect the school system to babysit their children. Some parents also want the schools to solve all their problems. IT is time for the parents to step up and get involved with their child's education.
8 Agrees | 1 Disagrees | Report Abuse »
If we are going to produce a workforce that can compete on the world market education has to start early. Good for WV.
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Showing 7 of 7 comments


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Posted on June 5, 2014 in Strings
For a great many professional tennis players, there is no substitute for Luxilon strings. My splurge this week is one of the most iconic Luxilon strings, Big Banger Original, which was among the first crop of Luxilon co-polys to start popping up on the pro tour in the late 1990s-early 2000s. For those who want to get the firm feel and incredible control of the Big Banger Original without having to spend over $10, I would recommend Solinco Outlast. While no two strings play exactly alike, I think Outlast is a worthy substitute for Big Banger Original. Psst: it also received a higher spin rating in our TWU string lab.
Check back next week for another edition of save vs splurge!
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If Pens sign Parise, what are they gonna do when Malkin's contract is up. I for one think Parise is gonna sign here, providing Suter does, I think its gonna be a Kariya/Selanne Avs signing years ago kinda thing.
And if Parise goes to the Pens, then maybe he does wanna be in Crosby's shadow. We'll just steal Malkin when his contract ends, lol
If thats the case hopefully Suter and Parise don't play like Kariya and Selanne did when they were with Colorado!


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A state rail infrastructure grant could mean more jobs for a city manufacturer and increased business opportunities for other area companies if the application is approved.
Lycoming County commissioners approved applying for a $350,000 state Department of Transportation rail assistance grant Thursday on behalf of NuWeld, 2600 Reach Road, that would allow for greater use of a 20-ton crane at the plant's transloading facility.
Used in a limited capacity for about the past 30 years, the crane would be used to load and offload products at NuWeld, which specializes in mechanical services, including welding, engineering and fabrication for the nuclear, natural gas and power industries.
Article Photos
MARK NANCE/Sun-Gazette
Mike Miller, of NuWeld, keeps an eye on a 20-ton overhead crane as he uses a remote to control it at NuWeld on Reach Road Thursday. Lycoming County commissioners and NuWeld hope to use a grant to open the crane up to railroad use. NuWeld uses the crane, but the railroad tracks to it need to be replaced.
MARK NANCE/Sun-Gazette
Officials and Lycoming County commissioners stand in front of a 20-ton overhead crane that they hope to open up to railroad use. NuWeld uses the crane, but the railroad tracks to it need to be replaced. From front left are Gene Hillyard, Gary Evans, Gay Bartlebaugh and Tyler Satterfield with NuWeld; county Commissioners Ernest Larson, Jeff Wheeland and Tony Mussare; and Michele March, of NuWeld. From back left are Caleb Derr, Jim Dwyer, Mike Caseman, Bradley Dodd and Terry Bartlett, all of NuWeld.
The total $513,000 project could bring in 60 to 120 jobs if the grant is approved, according to company officials. NuWeld would be required to provide 30 percent of the total cost.
Caleb Derr, NuWeld contract administrator, said the project would expand the company's supplier base and make shipping and receiving products much more affordable.
"This is one of the components in an already diverse investment (plan)" at NuWeld, Derr said.
Other industries on Reach Road and beyond would have access to the crane and would benefit from additional shipping and receiving options.
Rail service into the facility would take numerous tractor-trailers off the highway, Derr added.
"Everything about it is more efficient," he said.
If approved, about 2,000 feet of old, half-buried rail line will be replaced.
Vincent J. Matteo, president and CEO of the Williamsport-Lycoming Chamber of Commerce, endorsed the project at the commissioners' meeting on Thursday, saying it would help create and retain jobs.
"This project is the type of project that government should be involved in," he said.


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Expanding Use of NGS Has Largely...
Wall Street Decline Takes Its Toll...
LC-MS Gains Favor Due To the...
Developers of DTC Genetic Testing Are...
The emphasis on process understanding has been part of pharmaceutical development strategy since FDA's 2003–2004 promulgation of GMPs for the 21st Century. Oligonucleotides were almost nonexistent in major pharmacopoeias at the time. Now that oligo drugs are nearing late development and commercialization, analytical tools for speeding process development will come to the fore as they have with small molecules and therapeutic proteins.
A new software package from BioSpring for characterizing oligonucleotide synthesis products shows promise for characterizing unknown side products and impurities during and after oligo synthesis.
LC/MS is well established for identifying known compounds and confirming identity from mass peaks. Characterizing small molecule impurities, even unknowns, is facilitated by fragmentation patterns and computerized access to spectral libraries. LC/MS is not as routine or straightforward for oligonucleotides, whose synthesis creates a host of impurities and side products.
"You can't tell what these are simply from the mass information," notes Susann Rosmus, Ph.D., head of quality management at the company. Since impurities from each synthesis step carry over, the potential list can get quite large. Each step in an oligo synthesis involves protection, deprotection, and addition of a base. Reactions are never quantitative, so the impurities can add up rapidly after every step. In addition to N+ and N- entities, product may include salt adducts and unremoved protecting groups.
"If you have an N+1, you would detect a mass around 300 higher than main mass," Dr. Rosmus explains. "But it could also be a protecting group plus something else, or an adduct from the buffer system."
OligoFrag picks all MS-detectable impurities out and verifies their identity using a "special algorithm," Dr. Rosmus says. How does it work? Before the synthesis, the identities of all protecting groups, potential salt adducts, and of course the bases, are entered into the program. Since the masses are unique to the spectrometer, the program provides impurity identities by matching up the measured masses with calculated values.
"The software gives all different possible combinations matching the detected mass," she adds.
Last year, BioSpring became the first European company to obtain a GMP certificate for producing synthetic oligonucleotides. The certificate allows the company to manufacture oligonucleotide active pharmaceutical ingredients. BioSpring has entered a commercial manufacturing agreement with Sanofi for therapeutic oligonucleotide manufacturing.
In-process analysis of purification fractions creates a bottleneck in oligonucleotide manufacturing. Sample preparation and analysis can stall production for two days or more, according to Todd B. Kreutzian, director, analytical development, Agilent Technologies.
Agilent recently introduced an automated 2D UHPLC UV/MS method designed to relieve the bottleneck. The method combines automated sample preparation of high pH/high salt samples with rapid quantification of N+ and N- RNA impurities. "It's a key component of process control strategy," Kreutzian says.
N+ and N- strands—single base additions or deletions of the full length material—result from over- or under-addition of bases during manufacturing or synthesis.
The method involves an Agilent 1290 Infinity UHPLC equipped with a binary pump module with solvent degasser, autosampler, heated column compartment, ultraviolet detector, and several other modifications.
"Our goal was to establish a set of analytical parameters that indicate purity for in-process samples at a pH and at a salt content (pH ~12 and ~1.5M NaCl) not suitable for ion-pair reversed-phase chromatography," Kreutzian explains. Another objective was to duplicate the current QC method for in-process samples but a higher speed and throughput.
Further, the method employed a 2D chromatography system to achieve automated, in-line sample desalting and neutralization with minimal operator intervention. The first chromatographic dimension consists of neutralizing and desalting. After neutralization and desalting, the sample is back-flushed off of the desalting column onto the head of the analytical column.
"The 2D system did not use any custom equipment," says Kreutzian. "All equipment, the pumps, valves, autosampler, and detector, are off-the-shelf items. Instrument control and data analysis is achieved through Agilent's OpenLab ChemStation software without custom macros or additional programing.
The method works as designed for critical validation endpoints:
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text:
Manager Named for Jersey Marketing Service
Manager Named for Jersey Marketing Service
Jason Robinson assumes Manager position, Erica Davis joins administrative staff of national marketing company
Neal Smith, Executive Secretary and CEO of National All-Jersey Inc., today announced the hiring of two staff members for NAJ subsidiary, Jersey Marketing Service.
Jason Robinson, principal of Orion Cattle Services, New Holland, Ohio, has been named Manager of Jersey Marketing Service. Erica Davis, Washington Court House, Ohio, will assist with marketing and promotion for all JMS activities and provide on-site support for public auctions.
"We are pleased to add Jason and Erica to the JMS staff," Smith said. "Each brings a strong professional reputation and proven performance to the company and will use their skills and experience to serve buyers and sellers of Jersey cattle and genetics."
As manager, Robinson will be responsible for all day-to-day operations of Jersey Marketing Service. "Jason's practical experience from the cow side of sale management will be very valuable," Smith continued. "He has managed sales in the barn for many years, in addition to working on sale selections and overall event management."
Robinson brings over 20 years experience in livestock marketing to this position. Orion Cattle Services was established as a professional service provider to purebred cattle marketers in 1998, and he has steadily grown the business to work from 30 to 35 tie-up and commercial sales annually. He has worked extensively with the Guernsey Breeders Association; Modern Associates, St. Paris, Ohio; Brown Swiss Sale Service LLC, Lake Mills, Wis.; and since 2005, Jersey Marketing Service.
Jason has served as a 4-H leader and as secretary-treasurer for the livestock and sale committees in Fayette County, Ohio, and is currently a director of the Ohio Milking Shorthorn Society. He bred and owned the unanimous 2010 All American Junior 3-Year-Old, Blue Spruce HTA Melody Mya. She was Reserve Intermediate Champion of the 2010 International Milking Shorthorn Show at World Dairy Expo.
"I am excited about joining Jersey Marketing Service as manager, and look forward to working with its growing list of customers," Robinson said. "My goal in business has always been to treat people the way I would want to be treated, and to sincerely do a good job for buyers and sellers."
A native of Kutztown, Penna., Erica Davis grew up on her family's 120-head dairy operation, Daview Farm. She was selected a National Distinguished Junior Member by Holstein Association USA in 2000, and was twice a member of the champion team in the National Junior Holstein Quiz Bowl.
Davis earned a B.S. degree in agricultural science with a minor in agricultural communications from The Pennsylvania State University in 2004. She completed internships as World Wide Sires Ltd. and Accelerated Genetics, then joined the staff of Purebred Publishing Inc. as editor of Ayrshire Digest for two years. Erica also served one year as editor of the Ohio Jersey News. For the past eight years, she has also worked preparing cattle of all breeds for shows and sales.
Through November 30, Jersey Marketing Service has generated gross sales of $8.3 million through private treaty transactions and public sale management of more than 6,100 lots. Highlights of the year have included introduction of the online auction website at JerseyBid.com; near-record averages for the National Heifer Sale, Pot O'Gold Sale and The All American Jersey Sale; and the highly successful two-day dispersal at K&K Jerseys LLC, Newton, Wis.
Founded in 1971, Jersey Marketing Service policies are set by a Board of Directors representing the 1,000 producer-members of National All-Jersey Inc. and more than 2,300 members of the American Jersey Cattle Association. Company offices are located at 6486 E. Main Street, Reynoldsburg, Ohio 43068-2362.


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on February 26, 2013 - 4:52 PM
LOCKPORT – A Level 2 sex offender pleaded guilty in Niagara County Court Tuesday to failing to register a change of address and possession of powdered cocaine.
Jason M. Klinger, 37, of Hewitt Parkway, Lewiston, was promised a sentence of no more than 2 1/2 years in state prison when he returns before County Judge Sara Sheldon Farkas May 7. She could have given him up to 6 1/2 years. Also as part of the plea deal, a probation violation on Klinger's previous conviction was dismissed.
He was living on 15th Street in Niagara Falls when a probation officer found him in possession of 760 milligrams of cocaine during a March 9 home visit. Klinger failed to inform the state of his move to Lewiston in September, as required by law.
Klinger went on the sex offender registry after pleading guilty in 2011 to a reduced charge of attempting to possess child pornography. He was placed on six years' probation at the time.


text:
Source: Nokia
quote: Windows Phone is well funded too. Microsoft will make $3.4 billion from Android in 2013 http://www.neowin.net/news/microsoft-will-make-34-...
quote: You should read the Galaxy S4 reviews on the hanging and stuttering even on the 8 core processor. How many cores will it take before Android gets to smooth and stable?
quote: I expect better from a phone than just good enough.
quote: While you may not be impressed with Windows Phone


text:
Shirred Eggs
Serves 1
This is a no-recipe recipe, needing only general guidelines, and perhaps an initial experimentation to know the dish and oven, as each changes the time needed for cooking. And everyone likes their eggs cooked differently, some oozy, some firm. Write down the dish, temperature and time that suits you, so next time you will have it as a firm guide.
Nathalie Dupree
Nathalie Dupree is the author of 13 cookbooks, most recently "Mastering the Art of Southern Cooking." She lives in Charleston and may be reached through Nathalie dupree.com.
1/4 tablespoon butter
2 eggs per person
1/4 to 1/3 cup heavy cream
Other herbs or ingredients as desired such as tarragon, garlic, chopped tomato, cooked onion, etc.
Preheat oven to 350 degrees. Lightly butter the bottom and sides of small ovenproof dish sufficient to hold two eggs side by side. Crack the eggs, one by one, and slide into the bowl. (All the better if you put in a bowl first then slide in, to make sure you are clear of egg shell.) Add pepper and any other seasonings or ingredients as desired, avoiding salt, which may toughen the eggs at this time. Pour heavy cream on top to cover, or as much as you like. Move to a small baking pan or put directly into the oven on a rack if living dangerously. Cook 3 to 5 minutes, or until at desired consistency. Remove dish to a plate. Season with salt if desired. Serve with toast sticks or quarters.


text:
on December 21, 2012 - 12:11 AM
St. Joe's hockey downs North
Eric Paradowski's goal just two minutes into the game did a lot more than give the St. Joe's hockey team an early lead against Federation rival Williamsville North.
"That was a big play, to get on the board early," St. Joe's coach Rick Crozier said. "It was a huge goal. In a big emotional game like that, it was so critical for us to strike first and get some confidence."
The Marauders rode that confidence to a 3-1 win over the Spartans. North tied the game four minutes later on a goal by Jared Cummins.
St. Joe's took the lead for good in the first when Kyle Moslow connected. The game stayed 2-1 until three minutes were left when Mike Iannello added an insurance goal on a slap shot from the point that found the top corner.
Goalie Nick George had 21 saves as St. Joe's outshot North, 27-22. North went 0 for 7 on the power play.
The Marauders won't be celebrating this one for long. They take the ice tonight against Niagara-Wheatfield at 7:30 at Dwyer Arena in the game that will determine first place in the division.
Elsewhere, senior goaltender Dalton Kruger had 21 saves to earn his first shutout as West Seneca West moved to 4-0-1 with a 1-0 victory over Lew-Port at Hyde Park.
Kruger had seven saves in the third period, including a nice stop on a semi-breakaway with about two minutes left. He also emerged unscathed after a scramble in front of the net with just seconds left.
The only goal of the game came off the stick of Pat Ciancio in the second period on an assist from John Danovskis.
Marauders move to 5-1
The St. Joe's basketball team put together its best game of the year, according to its coach and came away with a 77-54 victory over Middle Early College.
The game was close for the first 12 minutes before St. Joe's went to a 2-3 zone. "That changed the tempo of the game," coach Mark Simon said. "They struggled to score and we were able to run some offensive sets. It was our best effort to date. A lot of guys contributed."
Justin Hollins had 19 points and Jaylen Morris added 18 as the Marauders improved to 5-1.


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OJ back to Las Vegas Court in Bid for New Trial
LAS VEGAS (AP) ? O.J. Simpson is back in a Las Vegas courtroom to ask for a new trial in the case that sent him to prison in 2008.
The former football hero and a new set of lawyers hope to convince a judge during a hearing that began Monday that trial lawyer Yale Galanter (gah-LAN'-ter) had conflicted interests and shouldn't have handled Simpson's armed case.
Simpson appeared in court wearing a blue jail uniform. His hair was short and grayer than it was during a previous court appearance in 2008.
He entered the courtroom in handcuffs, flanked by guards and nodded toward people he recognized in the second row.
Simpson is serving nine to 33 years in a Nevada prison. He's due to testify Wednesday.
Simpson says that Galanter knew ahead of time about his plan to retrieve what he thought were personal mementoes from two sports memorabilia dealers at a casino hotel room in September 2007.
Simpson also says his lawyer never told him a plea deal was on the table.
Source: Associated Press


text:
Top Definition
the word alot and a little combined together.
meaning a little bit more than alot.
meaning a little bit more than alot.
they love each other alottle.
от yummyummandbuttbutt 21 януари 2009
Trending Now
Can you define these popular missing words?
the opposite of a little. someone will bring up how little you like a particular thing and you come back with this word
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not really just a little...
Yeah right! you like them a lottle!
not really just a little...
Yeah right! you like them a lottle!
от nigga Jay 08 август 2007
It's like a little, but a lot
I love you a lottle
от Quakerz 07 януари 2015
A large quantity of something or to say something is more than average.
You're silly, alottle silly.
от TheCavalier 10 август 2010
it's a little except a lot.
I love you a lottle.
от xXKITTYXx^~^ 26 март 2016
thoughts are supposed to create good grammar but dont always & infact the jibberish that comes out of ones mouth after neurotransmitters misfire can sometimes end up creating unique, efficient, cunning, ingenuous, thought invoking words that most importantly crack the lips with a pearly white smile followed by a good chuckle. 'alottle' comes from my girlfriend asking how much salt to add to a salsa recipe i then replied while thinking, not too much BUT more than a little "ALOTTLE".
от skinnybigguns 24 февруари 2010
saying its a little bit but lying because its a lot
I love you just a lottle bit
от gabbystorring 24 февруари 2015


text: Complete Game Gives Stetson Series Clinching Win April 07, 2013 JACKSONVILLE, Fla. – Behind a complete game on the mound from junior Austin Perez, the Stetson baseball team (15-17, 4-5) defeated Jacksonville (11-21, 4-5) by a score of 8-1 to win the final tilt of the weekend and capture the squad's first Atlantic Sun Conference series victory of the season. "AP made one bad pitch in the first inning, giving up an 0-2 RBI base hit, and then settled in, and was just really, really good," Stetson head coach Pete Dunn said of Perez on Sunday afternoon. Really good he was, allowing just six hits in the first complete game of the season for the junior. Perez struck out four batters, walked just one, and retired 13 straight batters before giving up a single in the bottom of the ninth. Jacksonville scored its only run of the game after a pair of singles made it 1-0 in favor of the Dolphins in the bottom of the first. It was all Hatters after that, as not only was Perez nearly untouchable, but the Stetson bats delivered, and the defense failed to record an error for the second straight game. "It's a pretty simple game," Dunn said. "If we go out and have good pitching, play good defense, swing the bat well – and we really talked about the short game – everything we talked about before the game, we really went out and did a good job with. "We got bunts down, we advanced runners, we executed some hit and runs, we got some key base hits with two outs, and we got runners in from third," Dunn continued. "It was a great effort. We talk about games that you use as a template, and that was a template game right there. That just shows you if we play the game like we're capable of, we're going to have a chance to win. That's all you can ask." Stetson took its first lead of the game with a pair of runs on the third inning. Junior K'Shawn Smith led off the frame with a single to left field, and advanced to second on failed pickoff attempt by Jacksonville pitcher Alex McRae. He then came around to score on a single by freshman Kevin Fagan. The Hatter rally continued when sophomore Tyler Bocock laid down a sacrifice bunt to advance Fagan to second. After freshman Patrick Mazeika was hit by a pitch, Saturday's hero sophomore Garrett Russini drove in Fagan with another single up the middle to give Stetson a 2-1 advantage. It was again Smith leading off in the fifth when Stetson scored three more runs to make it 5-1. This time the second baseman was hit by a pitch to put the leadoff Hatter on. After Fagan singled to center, Bocock advanced the runners once again with a sac bunt. Mazeika drove in both Smith and Fagan with the first extra base hit of the series for Stetson. The first baseman, who extended his hitting streak to 15 games on Sunday, hit a double down the right field line to put the Hatters up 4-1. Senior James Rasmussen then drove in the third run of the frame with a single to center field. After Perez recorded his second of three straight perfect innings in the bottom of the seventh, Stetson added two runs in the eighth to put this one nearly out of reach for the Dolphins. Senior Mitchel Brennan started the mini rally with a double to the gap in right center. Smith tallied his third single of the day to drive in sophomore Tanner Blackman, who came in to pinch run for Brennan. A single by Fagan, his third of the game, sent Smith to second, and a wild pitch advanced the junior to third. With his third sacrifice of the day, this time of the fly ball variety, Bocock drove in Smith to make it 7-1 in favor of Stetson. The Hatters added one run in the ninth inning to finish with the 8-1 victory. Perez improved to 4-1 on the season with the win, while JU's McRae fell to 2-3 with the loss after allowing five runs on nine hits in 5.1 innings. Fagan, Mazeika, and Smith all finished with three hits on the day, while Mazeika's two runs batted in led the Hatters. Jacksonville was led at the plate by Dylan Dillard, who went three-for-four on a trio of doubles. Stetson will get right back at it with a road game at Bethune-Cookman on Monday. The game, re-scheduled from a rain out earlier this season, is scheduled to begin at 6:00 p.m. in Daytona Beach. The Hatters will then play at Miami on Wednesday before getting back into conference action at USC Upstate next weekend. "We're still not taking giant steps, we're taking baby steps, but this was a big step for us right here," Dunn concluded. "We really felt that we needed to get two out of three up here. Hopefully these last two games get us going."Print Friendly Version More Headlines


text:
Thursday, April 4, 2013
The students in third through fifth grade are participating in the pilot program, Engaging Creative Minds, which provides students access to innovative arts and learning opportunities based on Common Core standards.
These students, along with the rest of the fifth graders, created art work about Reconstruction and wrote personal narratives based on a character in their painting.
Fifth grader Ava Elliott had a great time. "It was really cool," she said.
"Mrs. Antonelli taught us how to do a water color resist with crayons," she added. "And then we reviewed Reconstruction. We did art with Social Studies."
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text:
Have you noticed that certain months of the year produce a particularly stellar selection of famous saints' feasts? August is one of those months, beginning on the first day with St. Alphonsus Liguori, doctor of the church and founder of the Redemptorists. Actually, this celebration of saintly all-stars really begins on July 31 with the Feast of St. Ignatius Loyola. Ignatius' day fell on a Sunday this year, which is why you didn't hear much too about him in church. But the Jesuit blogs were busy.
Back to August. The fourth day of the month celebrates St. John Vianney, patron of priests. Yesterday, Aug. 8th, was the Feast of St. Dominic, founder of the Order of Preachers, and of recently canonized St. Mary McKillop, the pride of Australia. Today, the 9th, is for St. Edith Stein, who was executed during World War II in the Auschwitz gas chamber, and tomorrow commemorates St. Lawrence the Martyr, who may hold the record for the most gruesome death. On Aug. 11th, the Church celebrates three famous females: the saints Susanna, Clare and Philomena. Another famous female saint is venerated on August 12, St. Jane Frances de Chantal. Two days later comes the feast of s second 20th century martyr, St. Maximilian Kolbe, who took the place of a doomed young husband at Auschwitz. His feast falls on Sunday this year. Of course, on Aug. 15, the church will observe the Feast of the Assumption.
For those of you who are of Hungarian descent, the feast of your national patron, St. Stephen the Great. is on Aug. 16. Aug. 18 is the feast of St. Helena, mother of the Roman Emperor Constantine, who ended the persecutions against Christians in the year 312. Helena is credited with the discovery of the cross of Christ. St. Bernard of Clairvaux, monastic reformer, is honored on Aug. 20, while the feast of Pope St. Pius X is the next day. Aug. 22 is the feast of St. Andrew the Scot, who actually was an Irishman. The feast of St. Rose of Lima, patroness of the Americas, is on Aug. 23, followed the next day by the feasts of St. Bartholomew and St. Nathanial, who were the same man! Don't ask me how that happened.
Aug. 25 brings the feast of King St. Louis of France, credited with discovering Jesus' crown of thorns, then building the exquisite St. Chapelle in Paris to house the crown and other precious relics. That church is the inspiration for the Lady Chapel in our own St. Patrick's Cathedral and for St. Joseph's Cathedral in Hartford, Conn. St. Louis shares Aug. 25 with St. Genesius, patron of actors, who was converted while satirizing the role of a catechumen about to be baptized. God touched him right in the middle of the performance. On Aug. 27, one of the great women of the church is honored – St. Monica, mater to St. Augustine of Hippo, whose feast is the very next day.
Who's your patron saint? Google your name and find its origin. Maybe you carry the name of one of these or the hundreds of August saints I haven't mentioned. Maybe some facet of your personality or life resembles that of your namesake. Or, if you have an August birthday, find out whose feast it is. Celebrate your connection.
I'll be on vacation for the next few weeks but if I see something interesting, I'll post. Enjoy the rest of this saint-rich month.


text:
16" Rim Planter, Brick
This item is currently not available.
Additional Information
Get the Look of Glazed Pottery in a Lightweight, Self-Watering Pot
- Lightweight, durable container resembles heavy pottery
- Self-watering to reduce watering chores and provide plants with consistent moisture
- Perfect for bold and stylish flower displays
Even up close, these pots resemble substantial pieces of pottery — until you pick them up and realize they're made from lightweight polypropylene with a high gloss finish. Unlike pottery, these pots won't crack or chip. Inside, a hidden 1-gallon water reservoir reduces maintenance and helps keep plants lush all season long. Hand-painted; color may vary slightly.
Product Details
- Polypropylene
- 16" top diameter; 9-1/2" base diameter; 14" H; 3-1/2" rim
- Holds 30 quarts of container mix
- 1-gallon water reservoir
- Made in USA
- Gardener's Supply Exclusive
There are no special shipping restrictions or charges associated with this item. For detailed information about our delivery methods and charges, click here.
We're proud of the fact that this item is shipped to you directly from our warehouse in Vermont, by one of our 250 employee-owners. In-stock items are packed with care and shipped within the next business day to ensure prompt delivery to your home and garden!


text:
From Mirror reports
It didn't take long for the Altoona Curve to sell the vast majority of available tickets for the March 30 exhibition game against the Pittsburgh Pirates at People's Natural Gas Field.
The Curve began the sale at 9 a.m. Saturday, and by 1:30 p.m., including season-ticket, mini-plan holders and other pre-sale opportunities, more than 6,000 tickets had been purchased.
Curve General Manager Rob Egan said lines outside the ticket office began forming "around 5:30 a.m.," and stretched around the main gate and toward the parking garage until well after noon.
"We weren't exactly sure how it would play out so I would say it exceeded what we expected for today," Egan said. "We were glad it was nice, temperature-wise, and we were able to get everybody through. We just appreciate everybody's support, and we're thrilled to have the Pirates coming here."
Egan said the process "took a little longer" than anticipated because the team was taking contact information for fans who were given a voucher for the commemorative ticket. The actual tickets will be available starting March 1.
Egan said about 150 seats remain in the left-field bleachers, along with "a few scattered singles" in other sections. Those tickets, along with standing room, will go on sale Monday morning.
"We don't have a lot of seats left, but there is plenty of standing room with good viewpoints," he said.
Fans can buy them at the box office, online at altoonacurve.com (beginning at 9 a.m. Monday) or by calling the Curve at 877-99-CURVE.
Seating capacity at PNG Field is 7,200, but Egan can envision another 3,000-plus standing-room tickets being purchased.
"We're thinking we could get to 10,000," he said.
The Curve's all-time attendance record is 9,308, set when they hosted the Eastern League All-Star Game in 2006.
The Pirates' previous exhibition game here in 2000 drew 7,346.


text:
Sheriff to boost drug task force, hires deputy
April 20, 2013
LISBON — A new sheriff's deputy has been hired as part of a plan to increase manpower at the Columbiana County Drug Task Force....
notSocialist: What is your issue?Seems to me, your whole world revolves around your weapons. Any chance you belong to any Veteran organizations? You remind me of someone I once met.
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Maybe the Sheriff should hire someone to help get the murderers off the streets! I guess murder is not top priority. Maybe you will be next!
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quote Luigi97broOh brother. Got to catch them all! Seel ditto golem oh yes.{color=grcolor}[color=green]the best moves for typhlosion are Shadow claw,Eruption,Earthquake,Blastburn and probly one super awesome move of your choice
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