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Molecular imaging is broadly defined by the Society of Nuclear Medicine as "the visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and other living systems." It is used extensively in drug discovery and development, for diagnosis and to monitor the efficacy of therapies.
With so many modalities, from CT and PET to ultrasound and MRI and compounds, from radiolabeled pharmaceuticals to fluorescently labeled small molecules to dense contrast agents and players in the field, it was inevitable that "In Vivo Molecular Imaging in Drug Discovery and Development" would draw a diverse slate of speakers. The June meeting brought those working on the physics and chemistry of probe construction together with clinician-scientists, to discuss current issues in and future directions of the field.
The range of techniques, agents, and stakeholders involved in molecular imaging creates variations in imaging results. Reasons for poor quality include:
Through its Clinical Trials Network, the Society of Nuclear Medicine is working to forge order out of all that chaos. Click here for more.
A common theme among the conference's participants is that development of molecular imaging agents should start early in the drug development process. According to Juri Gelovani, M.D., Ph.D., president of the Academy of Molecular Imaging, this should happen as soon as a clinical target is locked in, perhaps even preceding development of the therapeutic itself.
Whether it's measuring target expression levels or levels of receptor occupancy and determining pharmacodynamics or pharmacokinetics, the effects of biological approaches need to be validated in parallel to drug development in order to allow for timely transition into the clinics, concurred Thomas Krucker, head of molecular imaging for the global imaging group at Novartis Institutes for BioMedical Research. Co-development of the drug and diagnostic together would save time and resources.
Molecular imaging should be integrated with the drug discovery project teams, rather than run like a core service. At Novartis, he said, they develop customized solutions that use imaging to seek information that can't be found through other technologies.
Labeled biopharmaceuticals are an obvious source for imaging agents, Krucker said. Yet many biologicals display properties such as slow clearance and low target to background ratios, and because of their large size they may suffer from low stability or poor tissue penetration as well, making them less than ideal for the purpose. These issues can sometimes be addressed by engineering the proteins into smaller formats, for example Fab fragments or diabodies, instead of intact monoclonal antibodies.
Imaging agents, as compared to doses of therapeutic agents, are administered in very low amounts that don't induce pharmacologic effects, added Dr. Gelovani. They should provide quantitative information about the spatial distribution and magnitude of drug-target expression and activity in tumors as well as other normal organs and tissues.
Of course, sometimes the imaging agent should be as similar to the therapeutic agent as possible—especially if the goal is to track the therapeutic agent itself.
Stephen Mather, Ph.D., professor at Barts Cancer Institute, Queen Mary University of London, has been concentrating his efforts on using a variety of preclinical imaging modalities to optimize compounds destined to become pharmaceuticals. His presentation, sponsored by BioScan, focused on research using that company's dual-mode NanoSPECT/CT system.
In vivo preclinical imaging in animal models, he said, can help to identify much earlier in the process whether a drug is likely to ultimately be successful in patients.
His lab collaborates with GlaxoSmith-Kline on a project to target interferon (IFN) to the liver. IFN is known to be effective against hepatitis C infection, but because its receptors are present throughout the body, systemic delivery results in considerable side effects including hallucinations.
The researchers conjugated IFN to an antibody against the asialoglycoprotein receptor, which "is pretty much only present on liver cells," Dr. Mather said. They then radiolabeled the bi-specific compound. "We've shown quite convincingly that by tagging the IFN onto the antibody, you do get much more of the drug in the liver rather than elsewhere."
They also collaborate with several other academic labs across Europe in a program sponsored by the EU's Cooperation in Science and Technology program. The study compared which of nine different radiolabeled peptides seemed to best target a receptor found on medullary thyroid cancer. "This allows just one compound to be taken forward into clinical trials, which are increasingly difficult and expensive to do," Dr. Mather explained.
Following a traditional screening cascade from recombinant and native tissue to autoradiography to an in vivo radioimaging model, is very helpful in understanding whether something is potentially suitable as an in vivo PET radio tracer, said Donna Maier, Ph.D., who recently joined BrainCells. It's invaluable for exploring novel radioligands, and "it's also important for validating within your own lab, potentially for the first time, a radioligand that's available commercially."
While in the molecular imaging group at AstraZeneca, Dr. Maier's team worked on the a-7 neuronal nicotinic receptor (NNR)—an important target for psychiatric and cognitive disorders such as schizophrenia and Alzheimer disease. They would pretreat an animal with a drug compound before administering a radiolabeled ligand, and then dissect the brain at various time points.
Inhibition of the radioligand binding would imply that the drug is occupying the receptor. In this way, they were able to rank-order compounds to pursue further in PET studies. "It's a competition assay, but it's in vivo."
When one particular ligand was used, they found what seemed to be a paradoxical decrease in receptor occupancy by the microgram dose of the pretreatment compound, in which there were more receptors available for radioligand binding. "You're actually increasing the receptor density at the neuron and you're increasing the binding of the radioligand—and so it results in a mathematically negative receptor occupancy," Dr. Maier explained.
Some behavioral assays indicated that the animals may actually be more sensitive to less compound. Taken together, these studies "may indicate that you're looking at nontraditional dosing regimens as you translate preclinical data to clinical studies and try to administer this type of compound to humans," she said. "We found an interesting way to utilize molecular imaging and try to further understand our compounds."
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After watching his team give up one touchdown and just 245 yards at Georgia Southern — and lose anyway, 13-6 — Citadel football coach Kevin Higgins knew things had to change.
Date Opp. Time
Aug. 31 Charleston Southern 6 p.m.
Sept. 7 Wofford 6 p.m,
Sept. 14 at Western Carolina 3:30 p.m.
Sept. 21 at Old Dominion 6 p.m.
Sept. 28 Furman 6 p.m.
Oct. 5 Appalachian State 2 p.m.
Oct. 12 at Georgia Southern 1 p.m.
Oct. 26 at Chattanooga 2 p.m.
Nov. 2 Samford 2 p.m.
Nov. 9 at Elon 1:30 p.m.
Nov. 16 VMI 1 p.m.
Nov. 23 at Clemson TBA
"We've got to take a hard look at what we're doing," Higgins said after that loss on Nov. 21, 2009, which ended his fifth season at The Citadel with a 4-7 record.
3.8 -- Penalties per game last year, lowest in FCS
21 -- Years since back-to-back winning seasons
7.2 -- Yards per carry for FB Darien Robinson in 2012
14 -- Straight losses to Wofford
That was the first public indication that Higgins, who had made his name at Lehigh University with pass-happy spread offenses, would turn to the run-first triple option.
Higgins criss-crossed the country that winter, searching for players who could run the option — fleet-footed quarterbacks, hard-charging fullbacks, versatile slotbacks and smaller, more agile linemen.
He found quarterback Ben Dupree and fullback Darien Robinson in Pennsylvania and beat Wofford for running back Terrance Martin out of Cowan, Tenn. Running back Dalton Trevino came from Georgia, and Matt Thompson was a quarterback before becoming a receiver in the triple option.
The offense also allowed Higgins to plug quick-footed big guys — tight ends Cullen Brown and Devin Bice, defensive lineman Keith Carter — into his offensive line, even if they weren't 6-6 and 310 pounds.
The transition was not smooth. The Bulldogs fumbled 44 times while going 3-8 in 2010, and improved slightly to 4-7 in 2011. Last year's 7-4 mark was a breakthrough, the Bulldogs' second winning season in eight years under Higgins.
But this is the season the seniors in that first "option class" have been waiting for.
"There's been some trying times in the past," Thompson said. "But I feel like we've gained experience and knowledge of the offense. Now, we expect to showcase what we've learned."
Said Robinson, "It's been a building process since we got here. We feel like this is the year we're going to put it together."
Circumstances have conspired to help the Bulldogs, as well. Perennial Southern Conference powers Georgia Southern and Appalachian State are ineligible for the FCS playoffs and SoCon title this year as they transition to FBS and the Sun Belt.
That makes the SoCon title chase wide open — and Bulldogs fans expect their team to be right in the middle of it, along with Chattanooga, Samford and Wofford, which shared the championship with GSU and App State last season.
Higgins, 38-51 at The Citadel, has tried to put the brakes on happy talk with his motto of "1-0."
"Expectations for the season are high," he said. "And they should be. But people get caught up in talking about game No. 2 (Wofford), or Georgia Southern or App State. We want our guys to stay focused on the first game, and even more importantly on each practice. Just stay in the moment."
With a senior-stuffed backfield and offensive line, and an experienced backup QB in junior Aaron Miller, most of the Bulldogs' questions come down to filling holes.
Can sophomore Sam Frye make up for departed All-American Mike Sellers at center? Can sophomore James Riley and freshman Tevin Floyd carry the load for linebacker Carson Smith, lost in the preseason to a dislocated ankle? And can anyone approximate the skill of all-SoCon punter Cass Couey?
And then there is the question Citadel fans really want answered: Can the Bulldogs snap a 14-game losing streak to Wofford?
A win in that game would signal that the Bulldogs are at last ready to challenge for their first league title since 1992.
"No question," Higgins said when asked if this was the most confident he's felt at The Citadel. "The way we've prepared, the depth we have now, it's more than we've ever had. But, this league is much better than it's been before.
"We still have to play Georgia Southern and App State, and those games count. Chattanooga and Samford, they are not the teams they were four years ago. They are on the verge of being top 10 teams in the FCS. So it won't be easy."
HEAD COACH: Kevin Higgins, 38-51 in eight seasons at The Citadel; 94-76-1 in 15 seasons overall
LAST YEAR: 7-4 overall (5-3 SoCon)
IMPACT PLAYERS: QB Ben Dupree, FB Darien Robinson, LG Keith Carter, RT Cullen Brown, DT Derek Douglas, LB Carl Robinson, CB Sadath Jean-Pierre, CB Brandon McCladdie.
QUESTION MARKS: The two biggest holes to fill are those left by All-American center Mike Sellers and all-SoCon punter Cass Couey. Sophomore Sam Frye (5-10, 270) is plugged into Sellers' spot, and one of Will Vanvick, Eric Goins or Austin Jordan will take over for Couey. Another hole opened up when all-SoCon linebacker Carson Smith broke his ankle in preseason practice; sophomore James Riley showed last year he's ready for more snaps. In order to make a run at the SoCon title, the Bulldogs must improve their run defense and find a way to snap a 14-game losing streak against Wofford.

subset: commoncrawl


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Justine Wise of Tiffin has been called a rock star, but the 86-year old did not get the title for performing rock n' roll. It was bestowed after she received a telescopic lens implant in her right eye to compensate for end stage macular degeneration.
Her surgeon, Charlene Grice, assistant professor of opthamology at Medical University of South Carolina, said Wise is the first person in the southeastern United States to undergo the innovative procedure.
Last week, Wise returned to her rural Tiffin home. Her daughters, Kathie Aller and Sharon Breidenbach, and daughter-in-law, Maureen Wise, were present while Justine shared her experiences.
Article Photos
Justine Wise
Diagnosed with macular degeneration in 1995, she initially had a blurred area in the center of her left eye, but her right eye was compensating. Wise had been getting by with a magnifier for reading.
"It was to the point, I couldn't see that well, but at least I could see with my right eye yet. When my right eye went bad in 2005, I had to do something different," she said.
Earlier this year, her vision deteriorated even more, leaving her unable to write checks to pay her bills. She could distinguish light and dark but little else.
Aller took Wise into her home in South Carolina, but she also did research to find anything new that might help her mother. Then someone told Aller about a "60 Minutes" segment describing an experimental telescopic procedure.
"That started our search. I finally found this place called CentraSight in California," Aller said.
When Aller contacted CentraSight, the person on the phone said only four U.S. facilities were doing the telescopic implants, but one of them was in South Carolina, only about two hours' from Aller's home.
Aller also learned the procedure was no longer experimental. The FDA and Medicare had approved the surgery for end stage macular degeneration in those 75 and older.
Information from www.centrasight.com explains the surgery involves a 12-millimeter incision to remove the eye's natural lens and replace it with a tiny telescope about the size of a pea.
The telescope directs light to the healthy parts of the retina to improve straight-ahead vision. If successful, the surgery can improve the patient's vision by two or more lines on the eye chart. The surgery is similar to that done for cataracts, but a larger incision and more sutures are needed to support the device.
Aller made arrangements for her mother to be evaluated for the procedure. The doctors checked Justine's eyes to be sure the magnification would make any difference for her and that the telescope would fit into the eyeball. With her age, overall good health and lack of central vision in both eyes, she qualified right away. Grice decided to insert the telescope in the right eye to improve central vision, and the left eye would be used for peripheral vision. Follow-up training and therapy would teach Justine how to make them work together.
"Friday the 13th is my lucky day. That's when I had it done, July 13," she said. "That's the first time in 86 years that I've ever had surgery I was put to sleep for."
"The operating room was standing room only. They had people from all over the country in there. They had it on closed-circuit TV throughout the hospital. She's quite the rock star. When we take her for her appointments, that's what they call her," Maureen said.
A video of Justine's surgery has been posted on youtube. She also has appeared on television and has been featured in newspaper articles. Her goal is to let other people with macular degeneration know about the new treatment. She said her vision was noticeably better even before she started follow-up therapy to re-train her eyes and her brain.
"Now it's up to me. I've got a lot of training to do," Justine said. "It's going to take a lot of work, but I'm going to do it."
Aller said the pupil of the eye eventually will grow around the telescope and support it, in addition to the sutures. Wise has eye drops to apply each day. She already has started exercises, such as watching television programs and looking for specific objects and shapes. Her favorite programs are "Wheel of Fortune" and "The Price is Right."
"I've got a bigger deck of cards and I have to learn to hold them a certain space from me and then check the numbers and see the different suits and letters," Justine said.
"Everything she sees out of (the right) eye will be bigger," Aller said. "They've magnified her glasses about four times ... so she has to train her eye to look at the bigger image."
Justine expressed gratitude for her daughter's persistence and for the support she has received from all five children, 10 grandchildren and numerous other family members. Some have helped take care of her home and her bills, while others have stayed with her or transported her to appointments. All continue to offer emotional support.
"She's not going to be able to drive or anything like that ... but it will give her the opportunity to read, which she hasn't done in a long time, and just little things that we all take for granted that she's not been able to do," Aller said.
"When you get to that point when you can only see enough to walk around and daylight and dark, and there's something available, you're going to go with it," Wise said. "Since nobody knew anything about it in this area, we want to bring all that information back here."
To view Justine Wise's eye surgery, use the link www.youtube.com/watch?v=aZNFGkf1ogs.


text:
Venture Capital and the Structure of Capital Markets: Banks Versus Stock Markets
Ronald J. Gilson
Stanford Law School; Columbia Law School; European Corporate Governance Institute (ECGI)
Bernard S. Black
Northwestern University - Pritzker School of Law; Northwestern University - Kellogg School of Management; European Corporate Governance Institute (ECGI)
November 1997
Journal of Financial Economics, Vol. 47, pp. 243-277, 1998
The United States has many banks that are small relative to large corporations and play a limited role in corporate governance, and a well developed stock market with an associated market for corporate control. In contrast, Japanese and German banks are fewer in number but larger in relative size and are said to play a central governance role. Neither country has an active market for corporate control. We extend the debate on the relative efficiency of bank- and stock market-centered capital markets by developing a further systematic difference between the two systems: the greater vitality of venture capital in stock market-centered systems. Understanding the link between the stock market and the venture capital market requires understanding the contractual arrangements between entrepreneurs and venture capital providers; especially the importance of the opportunity to enter into an implicit contract over control, which gives a successful entrepreneur the option to reacquire control from the venture capitalist by using an initial public offering as the means by which the venture capitalist exits from a portfolio investment. We also extend the literature on venture capital contracting by offering an explanation for two central characteristics of the U.S. venture capital market: relatively rapid exit by venture capital providers from investments in portfolio companies; and the common practice of exit through an initial public offering.
Number of Pages in PDF File: 52
JEL Classification: G23, G32
Date posted: September 11, 1996
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text:
President Obama Addresses Congress on Health Care Reform
President Barack Obama's address to Congress last week helped to move the Congress closer to passing comprehensive health insurance reform. In his speech, the President stated his case to Congress: health insurance reform must pass this year. He stressed that repeating history by doing nothing is not an option and laid out specific benchmarks for reform. He reminded Congress that effective health reform is essential to restoring the country's long-term fiscal health and securing a stronger future for our children.
Despite months of setbacks, Congress is ready to continue the discussion on health care reform. In the Senate, the Finance Committee recently released an outline of their version of health care reform. The Committee is currently finalizing the text for their bill and plan to mark up their version of health care reform next week. In the House, health care reform could be debated on the floor in early October.
Want to stay informed about IMF's advocacy activities? All you need to do is to join the Myeloma Action Network at http://www.capwiz.com/myeloma/mlm/signup/ and you will automatically receive e-mail advocacy alerts from the IMF.
Advocacy Update Archive


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Emerson House
Welcome to Emerson House. We are a family of vintage "hunters and gatherers" who are passionate about style and craftsmanship. From fun and functional to elegant and sophisticated, we specialize in unique items acquired with a nod toward the days of handmade beauty and love the stories and history that come with each piece we acquire. Come join us on our journey with One Kings Lane!


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Top Definition
Usually a girl who is a stoner. She's beautiful has beautiful curves and she loves Life. She usually has long brown hair bug beautiful eyes & a bright smile. She's very close to nature & everybody loves her. Every guy begs to be with her.
Dude she was totally a haylyn.
Por Cammidanile 06 de enero de 2014
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Latest update : 2012-11-01
An overview of the stories making the French and international newspaper headlines. From Monday to Friday live at 7.20 am and 9.20 am Paris time.
2016-09-27 Hillary Clinton
'The first debate featured an unprepared man repeatedly shouting over a highly prepared woman'
INTERNATIONAL PAPERS - Tues. 27.09.16: US papers focus on who won the first presidential debate between Hillary Clinton and Donald Trump. Most analysts tend to think Clinton won...
2016-09-27 Hillary Clinton
'Who won the debate?'
FRENCH PAPERS - Tues. 27.09.16. We start this French press review with a quick spin through the US media and reactions to the first presidential debate. Here in France, 15...
2016-09-26 Russia
'Grozny 1999 – Aleppo 2016'
INTERNATIONAL PAPERS 26.09.16: As the Syrian regime – backed by Russia – ramps up its attack on Aleppo, one picture of the devastation has come to define a bloody weekend....
2016-09-26 Donald Trump
Trump and Clinton: 'It's all to play for'
FRENCH PAPERS 26.09.16: Clinton and Trump's upcoming TV debate dominates the front pages - for Les Echos the presidential race is a 'battle that's consuming America'. Also making...
2016-09-23 US police shooting
Fatal shooting shakes Charlotte's self-image
INTERNATIONAL PAPERS - Fri. 23.09.16: The city of Charlotte, in North Carolina, is in the spotlight today. The city has become the scene of protests and unrest following the...


text:
American Idol is back!
Season 12 premiered Wednesday night with the first auditions in New York City. And fans hoping to get a taste of drama from new judges Mariah Carey and Nicki Minaj were not disappointed.
"Right away we knew it was going to be an interesting couple of days," host Ryan Seacrest said at the start of the two-hour episode.
And he was right. (Spoilers ahead!) While fellow newbie Keith Urban and veteran judge Randy Jackson were all about the business of finding talented singers, there was immediate tension between Carey and Minaj, who wore a drum major's hat to her first day on the job.
"We can have accessories?" Carey said disapprovingly after taking her seat at the panel. "I didn't know that was allowed."
"Why did you have to reference my hat?" Minaj responded.
Later, when Carey boasted about her holiday hit, "All I Want for Christmas," Minaj clenched her fists, gritted her teeth and used the b-word. Carey's response? "I rebuke it," she said.
The two women talked over each other at times, rolled eyes and seemed to annoy one another. More than once Carey said "Nicki" like an frustrated mother calls her child out for misbehaving. And Minaj pushed Carey's buttons by talking in a British accent.
But as the two formerly feuding judges have said in recent interviews, the show should be about the hopeful contestants – and there were a handful of talented singers who earned golden tickets to Hollywood:
Tenna Torres, who attended Camp Mariah and had previously sung for the singer, impressed the panel with her version of "You've Got a Friend," and made her idol very proud.
Christina "Isabelle," who told a story of losing weight and finding confidence, had Minaj saying, "OMG! OMG!" with her version of "Summertime."
Frankie Ford, who sings for change on the New York City subway system, stumbled at first but delivered a soulful version of the Eurythmics' "Sweet Dreams." "I like your big voice," Urban said. "There's a lot of musicality in the tone."
Added Carey: "You have an inner glow, which is always beautiful to see."
Despite hearing loss in both ears, Angela Miller, who sang "Mama Knows Best" by Jessie J, was "definitely one of the best," according to Jackson.
And Ashlee Feliciano thrilled the female judges with her version of Corinne Bailey Rae's "Put Your Records On." "So pretty," Minaj said. "I want to come to your show ... I'm so inspired by you."
"The potential is great. It was beautiful," Carey said. "You should be really proud of yourself."
At the end of the first two days of auditions, the re-invented Idol panel had done its job: the judges praised the talented singers and handed out 41 tickets to Hollywood; they sent home the kooky contestants (often sweetly) and offered constructive criticism and an invitation to come back next year to the ones still on their way to greatness.
"We gel well in a weird crazy way," Minaj said at the end of the show. Carey said, "I agree."
We'll see how long that lasts! Auditions continue Thursday (8 p.m. ET) on Fox.
American Idol's New Judges Make Their Debut
Michael Becker/FOX.


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Faculty are the heart of Alderson-Broaddus College and many of the college's students become lifelong friends with their professors.
The value and significance of one such friendship was illustrated recently as an alumni couple acknowledged a faculty member's dedication and friendship by giving a gift honoring Dr. Timothy DeWitt, professor of music.
David and Karen Rainey's generous gift to A-B will be used to have DeWitt's studio named the "Dr. Timothy L. DeWitt Brass Studio," located in Paul Jones Hall.
"How honored and humbled I am by this generous gift to A-B, honoring my work in the brass studio," said DeWitt, in response to the recognition. "The fact that the presentation was made by Dr. Rainey and President Creehan during our 15th annual 'Brass in the Grass' concert this spring made it even more significant for me. On the floor of Wilcox Chapel that day were 90 brass players - current and former students, college alumni, area musicians and teachers - as well as music department colleagues, and friends. I consider this honor to be theirs as well, and I consider myself blessed to be able to do the work I do, with the people I am fortunate to call my students, colleagues and friends."
DeWitt is in his 30th year at Alderson-Broaddus. As professor of music, he teaches high and low brass, music issues and analysis, and serves as the department's recruitment coordinator. Under his direction, the Alderson-Broaddus Brass Choir has become regionally and nationally recognized, having toured primarily the Eastern United States and Canada, and completed its first European performance tour of Austria, Hungary and the Czech Republic in the summer of 2003. DeWitt was named A-B's Outstanding Faculty of the Year at the college's 2006 commencement ceremonies.
Current and former students from his studio have been named semi-finalists and winners in state, regional and national solo and chamber music competitions and have been accepted (and awarded assistantships) for graduate study at major schools of music throughout the country. Former students hold collegiate and public school teaching positions throughout the eastern United States and Canada, some having performed with such prestigious ensembles as the River City Brass Band, the United States Army Bands, the United States Navy Atlantic Fleet Band (Norfolk), Pacific Fleet Band (Hawaii), and Seventh Fleet Band (Yokosuka, Japan) the United States Air Force Band of Liberty (Boston) and Heritage of America Band (Langley, Va.), the Pittsburgh Symphony Orchestra, the Miami Symphony Orchestra, the Richmond Philharmonic Orchestra and the Glenn Miller Orchestra.
The Raineys currently reside in Daniels and work in Beckley. Karen Rainey is employed by Raleigh General Hospital as a staff surgical physician assistant. David Rainey works for Access Health Ob/Gyn and is on the staff of Raleigh General Hospital. During his A-B student years, he majored in biology, chemistry and education and he was active in multiple student organizations and music ensembles, including the Brass Choir. In 1989, Karen Rainey earned a degree in sports medicine and in 1991 completed requirements for a degree in medical science (physician assistant).
As a student, she served as a resident assistant, was active in Baptist Campus Ministries, played tennis and softball, and served as a student athletic trainer for the men's and women's basketball teams.
Karen and David Rainey have three daughters: Catherine, Emily and Heather. Catherine just finished her freshman year at A-B and looks forward to starting her sophomore year in the fall.
According to DeWitt, "The Raineys represent the spirit of A-B, with their continued commitment and dedication to the campus and its mission."
To learn more about naming opportunities to honor a faculty or staff member or alumni, anyone interested can contact the Office of Institutional Advancement at 304-457-6321 or email at firstname.lastname@example.com.


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Ablynx received a €3 million (about $4 million) milestone payment from Boehringer Ingelheim (BI) as part of the firms' ongoing alliance for the development and commercialization of up to 10 Nanobody® candidates in multiple therapeutic areas. Ablynx says it has now received €12 million in milestones through the collaboration, and could receive up to €125 million for each Nanobody therapeutic developed, plus additional royalties. BI retains responsibility for the development, manufacture and commercialization of products resulting from the partnership. Ablynx has certain co-promotion rights in Europe.
The latest news comes just 24 hours after Ablynx reported starting the first clinical trial with its lead in house Nanobody candidates targeting anti-von Willebrand factor, in patients with acquired thrombotic thrombocytopenic purpura (TTP). The trial will assess administration of both the intravenous and subcutaneous formulations of the Nanobody treatment as an adjunct to standard plasma exchange therapy. "We believe that our anti-vWF Nanobody may reduce the number of days a TTP patient is hospitalised for plasma exchange thereby reducing the overall number of plasma transfusions and increasing the quality of life for these patients," commented Edwin Moses, Ph.D., CEO and Chairman of Ablynx.
Nanobodies are antibody-based therapeutic proteins, generated in camelids, which comprise the structural and functional properties of naturally-occurring heavy-chain antibodies. Ablynx claims the molecules have a high homology with the VH domains of human antibodies, can be further humanized without any loss of activity, and have low immunogenic potential. Nanobodies thus display the beneficial features of both antibodies and small molecule drugs, the firm continues. They demonstrate high target specificity and affinity, are also extremely stable and easy to manufature, and could potentially be administered by means other than injection.
Ablynx's lead clinical programme ALX-0081, is an intravenously administered anti-thrombotic candidate that targets von Willebrand factor, and is currently also undergoing Phase II trials in patients undergoing percutaneous coronary intervention (PCI). The firm is separately developing a subcutaneously administered version of the Nanobody, ALX-0681. Both ALX-0081 and ALX-0681 will be administered in the Phase III TTP trial started yesterday.
Ablynx' third in house clinical program, ALX-0141, is a humanized Nanobody that targets the receptor activator for nuclear factor kappa B ligand (RANKL), which is a key regulator of bone metabolism. Ablynx aims to develop ALX-0141 for a range of indications including the treatment of osteoporosis. In September the firm reported positive results from a Phase I safety and pharmacokinetic study with ALX-0141 in healthy postmenopausal women.
Ablynx has a number of ongoing Nanobody development collaborations ongoing with partners including Boehringer Ingelheim, Merck Serono, Novartis and Pfizer. A Phase II trial with the Pfizer-partnered TNF-alpha Nanobody ATF-103, was initiated in September 2009.
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1. A dance style invented by Jay Kwan from Arlington, MA. It is catagorized by "smooth-fluid clubbing movements with subtle elements of popping, waving, and gliding". This style of dance is accompanied by techno/trance music.
This azn kid j-kwan can sure bust out the techno popping!
av Cr4ckShot 18 juni 2006
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Serves 6 |
Prep Time 10 minutes |
Cook Time 20 minutes
30 ounces Eden Lentils w/Onion & Bay Leaf, 2 cans, do not drain
14 1/2 ounces Eden Diced Tomatoes, 1 can, do not drainor Eden Diced Tomatoes w/Basil
2 cloves garlic, minced
1/2 cup diced onions
1 medium organic potato, diced
1/4 cup celery, diced
1/4 cup carrots, diced
1/2 tsp dried oregano
1/2 tsp crushed bay leaf
1 Tbsp Eden Extra Virgin Olive Oil
1/4 tsp Eden Sea Salt, or to taste
2 Tbsp fresh parsley, minced
Heat oil in a soup pot, sauté the garlic and onions until onions are translucent. Add all other ingredients, cover and bring to a boil. Simmer for 15 minutes. Garnish with parsley.
American, Beans, Condiments, Good/High Fiber, Good/High Protein, Low Fat, Macrobiotic, No Sweetener Added, Oils, Soup, Chili & Stews, Tomatoes, Vegan


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The falconry Galina in Malbun presents its various birds of prey in its open air show. The birds sail at a speed of 150 km/h above the heads of the audience. The explanations of the falconer make your visit not only a unique but also an educational experience for the whole family.
Whoever wants to see more of the feathered creatures, can follow the falconer, Norman Voegeli, on a special hike: the group is accompanied by the king of the air - the eagle. The 90 minute hike enables one to get to know the noble creature and to observe it in its natural environment.


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Amazon is looking to give potential Kindle buyers all the
more reason to pick up the newest version of the popular e-reader by shaving
$25 off the price, but customers will have to decide if an extra $25 in savings
is worth the on-screen advertisements being featured in the new model.
Amazon Kindle is a portable e-book reader that was introduced in 2007. The
introductory price was $399, and as new
versions were released over the years, the Kindle became slimmer with
a better display, more storage, and lower prices.
Amazon is
releasing the newest Kindle on May 3 and it possesses many of the same features
that the 6-inch Wi-Fi Kindle has, including a 50 percent better contrast with E
Ink Pearl technology, an 8.5 ounce body, a 6-inch display, Wi-Fi, 20 percent
faster page turns and enough storage for 3,500 books. The difference is that
the new Kindle will only be $114, and for the first time ever, the device will
feature special
offers and sponsored ads.
special offers and sponsored ads will appear at the bottom of the home page and
on its screen savers. Ads can be a major annoyance to consumers, but according
to Kindle Director Jay Marine, a lower price and the addition of advertisements
will be incentives for customers to buy the Kindle over any other competing
think customers are going to love it," said Marine.
Some of
the participating advertisers will be Procter & Gamble Co.'s Olay cosmetics,
General Motors Co.'s Buick and Visa Inc. JPMorgan Chase & Co.'s Amazon.com
Reward Visa Card.
noted that the ads would not appear in Kindle books. Ads can only be found on
the screen saver and home page, and they change frequently. If a user is
interested in an ad, they can click on it to have details e-mailed to
was very important that we didn't interfere with the reading experience,"
said Marine.
The new
Kindle can be pre-ordered here.
quote: But I admit, there is something nice about the touch and feel of a book. And I'm not quite sure I want to give that up. Kindle is nice because then you don't have books cluttered all around your house. But there's a part of me that thinks "I look at electronic displays enough. Do I really want to in my reading time?"


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Here's some not-so good news, Human Beings: Community returned down for its fifth season premiere Thursday. The NBC comedy's first episode drew 3.7 million viewers and a 1.3 in the adults 18-to-49 demographic, down six tenths from last season's opener, but it was on par with its May finale. The second episode bagged ...
Read More >
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Location, ST | website.com


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Top Definition
A nickname that is accociated with a Camel Light cigarette. The word derives from a student's surname that attended John Carroll University of, Ohio, from the years 2006-2010. He loved to smoke Camel Lights so much that eventually people started calling the cigarettes, "Bircher Lights."
"Buy me a pack of Bircher Lights."
"Smoke that cig like Bircher smokes it."
"Smoke that cig like Bircher smokes it."
von jcubrewcrew 3. Dezember 2007
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It's an appropriate time to reflect upon some of the pro wrestling personalities who passed away in 2013.
Many represented an era that will forever be etched in the memories of longtime fans.
They touched our lives in many ways. For those of us lucky enough to see them perform, we will never forget them.
They were athletes and performers who lived by the credo that "the show must go on."
Some lived out of a suitcase, spending more than 300 days a year on the road, working the territorial circuits during a time when the profession was much different than it is today.
Others never got to realize their full potential.
Some died far too young.
Angelo Savoldi was the world's oldest living professional wrestler when he passed away on Sept. 20 at the age of 99.
Savoldi, whose real name was Mario Fornini, began his career in the 1930s and became a five-time NWA world junior heavyweight champion. At the end of his career, near the end of the '60s and into the '70s, he worked for WWWF and was a minority business partner in the company.
Pro wrestling lost one of its true legends, the original "King of Memphis," Jackie Fargo, who died on June 24 at the age of 85 near China Grove, N.C.
Known for his "Fargo Strut," the colorful grappler was one of the most popular performers to ever headline the Tennessee territory.
WWE Hall of Famer Jerry Lawler called Fargo a "father figure" and one of the most influential people in his life. "Without the Fabulous Jackie Fargo, there would never have been a King Jerry Lawler," he said.
Maurice "Mad Dog" Vachon, one of the greatest heels in the history of professional wrestling, passed away in November at the age of 84.
The growling, gap-toothed tough villain was a former Canadian Olympic wrestler who bit and clawed his way to pro wrestling infamy.
Like Vachon, but nearly a foot taller, Dutch Savage (Frank Stewart) was as rough and tumble as any of the grizzled veterans he locked horns with during his days in the wrestling business.
One of the Pacific Northwest's biggest stars, Savage followed up an illustrious ring career as a successful real estate agent and an ordained pastor who taught King James scripture on public access cable out of Portland, Ore.
Savage, a master storyteller, passed away at 78 on Aug. 3.
Count Billy Varga, who died Jan. 11 in Burbank, Calif., one day after he turned 94, parlayed his many years as a professional wrestler into an acting career.
Varga often played a wrestler, boxing announcer or referee on-screen, including a role in Martin Scorsese's Raging Bull (1980).
For nearly 50 years Ron West did practically everything that could be done in the wrestling business. He was one of the most celebrated referees in the profession, as well as a respected booker, events coordinator, front-office man and promoter.
West passed away on May 15 at the age of 65, but left behind many great memories from a life well-served in the wrestling profession.
William Moody, a real-life mortician who gained international notoriety for his role as Paul Bearer, The Undertaker's portly, wild-eyed, urn-toting manager, died on March 5 at the age of 58.
Doug Gilbert, who passed away Nov. 4 at 76, underwent one of the most amazing transformations ever witnessed in the business. From a smallish-sized, high-flying performer to a powerfully built, 300-pound masked behemoth billed as The Pro, Gilbert's enigmatic character took the Georgia territory by storm during the late '60s.
Reid Fliehr, youngest son of wrestling great Ric Flair, was only 25 when he passed away.
"I loved him," Ric Flair said. "He should have been on top of the world, but he was fighting a battle he couldn't win. I hope people remember his laugh, his spirit and his love of life."
Among those we said goodbye to in 2013:
Count Billy Varga, Jan. 11, age 94; Marquis de Pare (Robert Pare), Jan. 16, 78; Billy the Kid (John William Guillot), Jan. 17, 76; Tito Montez (Edward Montemayor), Jan. 30, 78; Farmer Jones (Keith Iverson), Feb. 18, 73; Ciclon Negro (Eduardo Ramon Rodriguez), Feb. 20, 80; Ham Lee (Felipe Ham Lee), March 2, 80; Paul Bearer (William Moody), March 5, 58; Tommy Hanson, March 13, 75; Don Carson (Donald Gaston), March 14, 78; Eric The Great (Dennis Forsland), March 17, 79; Moondog Spike (Bill Smithson), March 21, 62; Charlie McGowan, March 26, 96; Reid Fliehr, March 29, 25; Don Duffy (Donald Quigley), April; 13, 80; Ella Waldek (Elsie Schevchenko), April 17, 82; Ron West, May 15, 65; Mick McManus (William George Matthews), May 22, 93; Buck Robley (Phil Robley), May 23, 68; Hector Garza (Hector Solano Segura), May 26, 43; Mark Starr (Mark Ashford-Smith), June 6, 50; Al Green (Alfred Dobalo), June 7, 57; Jackie Fargo (Henry Faggart), June 24, 85; Matt "Doink The Clown" Borne (Matthew Osborne), June 28, 55; Tinker Todd (Ramon Daniel Napolitano), July 14, 85; Geeto Mongol (Newton Tattrie), July 19; 82; Chuck "Scufflin Hillbilly" Conley, July 26, 75; El Brazo (Juan Alvarado Nieves), July 30, 52; Corey Maclin, July 30, 43; Vic Coleman, Aug. 2, 93; Dutch Savage (Frank Lionel Stewart), Aug. 3, 78; Frenchy Bernard, Sept. 16, 77; Angelo Savoldi (Mario Fornini), Sept. 20, 99; Gene "Cousin Luke" Lewis (Gene Pettit), Sept. 29; Dennis Hall, Oct. 18, 78; "Hardbody" Calvin Knapp, Oct. 20, 43; Doug "The Pro" Gilbert (Doug Lindzy), Nov. 4, 76; Roland Alexander, Nov. 5, 59; Maurice "Mad Dog" Vachon, Nov. 21, 84; Princess Salima (Joyce Farhat), Nov. 28, 83; Vivian St. John (Suzanne Miller), Dec. 21, 63.
Reach Mike Mooneyham at 843-937-5517 or email@example.com, or follow him on Twitter at @ByMike Mooneyham and on Facebook at Facebook.com/MikeMooneyham.


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I'm very happy to a doing a cooking demo and book signings Saturday and Sunday, Sept, 27 and 28th in Portland at Oregon's largest plant-based food event!
- Free samples of hundreds of different foods!
- Speakers
- Cooking Demonstrations
- Ask the Experts
- Family and Teen Activities
- Restaurants
- Non-Profit Organizations
- Film Screenings
I'll be the featured author at this year's Walk for Farm Animals. I will have copies for Vegan Chocolate and More Great Good Dairy-Free Dessserts for sale at a discount, and a percentage of sales will be donated to Farm Sanctuary.
The Walk for Farm Animals raises vital funds for Farm Sanctuary's lifesaving work and brings together thousands of people to change hearts and minds about farm animals. Will you join us in New York to support compassion for all?
- Early adult registration is only $15
- Event-day registration will be $25
- Children under 18 are FREE!
- Guest Speaker: Gene Baur, Farm Sanctuary's President and Co-founder
Walk Details
Central Park (Merchant's Gate)
October 18, 2014
Check-in: 10 AM
Yoga Stretch: 10:30 AM (provided by Derek Pashupa Goodwin)
Walk: 11 AM – 2 PM
*We will start the 2.25 mile route at 11 AM and will walk for about 1 hour. Celebration to follow.*
Directions and Parking: The New York Walk will be held at Central Park. You can enter "4 Columbus Circle, New York, NY" into your GPS for directions to the general area. We will meet at Merchant's Gate which is at the Columbus Circle entrance to the park (SW corner). For a visual guide, we will be at the red box on this map . The closest subway station is 59th Street – Columbus Circle (A, C, D, 1). You may plan your trip using public transportation at MTA.info. For those parking, you can visit this site to find the best parking rates for the area.
Entertainment: Musical entertainment to be announced.
Children's Costume Contest: This year we will be holding a children's costume contest at the New York Walk! Participants must be ages 12 and under and you may come dressed as anything you wish (it does not have to be animal oriented). Participants will be judged on realism and creativity! Extra points if it looks like you are having loads of fun! The winner will receive a prize, and there will be runner up prizes as well! We look forward to seeing what the younger generation of farm animal lovers will surprise us with! Any questions, please contact Farm Sanctuary: email@example.com.
Book Signing: Fran Costigan, "Queen of Vegan Desserts!" Fran is an internationally recognized culinary instructor, author and consultant whose innovative recipes marry healthy eating with sumptuous tastes. A professionally trained pastry chef, Fran worked in both traditional and vegan kitchens before moving into teaching over 22 years ago. She will be selling her books, Vegan Chocolate: Unapologetically Luscious and Decadent Dairy-Free Desserts and More Great Good Dairy-Free Desserts Naturally, at the Walk. Please bring cash to purchase.
Walk Information
The 2.25 mile Walk route can be found here. The Walk will be held rain or shine. Dogs are welcome at this event.
Everyone loves chocolate—and being vegan doesn't mean you have to go without it! What better expert to teach you the ins and outs of sweet, vegan chocolate-y goodness than Fran Costigan, author of "Vegan Chocolate: Unapologetically Luscious and Decadent Dairy-Free Desserts"? You'll also learn how to make gluten-free variations for some of the recipes. Your decadent menu includes: Intensely Chocolate Trifle; Sacher Torte; Blackout Cake; and Eclairs.
Please RSVP to Assistant at FranCostigan.com if you plan on attending.
My vegan chocolate demo, after dinner on Friday night, Feb 6th kicks off this sensational weekend as you explore the divine world of chocolate at Mohonk Mountain House. If you love chocolate, this is the time to visit the mountaintop! Get the best recipes, advice and samplings from those who have made their chocolate passion a lifetime pursuit. Chocolate infused Mohonk—two great things mixed together to create the ultimate chocolate obsession.
ART OF CHOCOLATE SPECIAL—15% OFF OUR REGULAR RATES. BOOK NOW! When making reservations, be sure to specify THE ART OF CHOCOLATE. Inclusive rates feature bountiful breakfast and lunch buffets with dinner as a traditional served meal, afternoon tea and cookies, and most activities, including use of the indoor heated swimming pool in our Spa wing.
Fran Costigan is a veteran culinary instructor, cookbook author, and the "queen of vegan desserts." She knows that even though you want vegan, gluten-free desserts, they can still be decadent enough to be worthy of Valentine's Day. Now you'll never have to spend too much time fussing over these desserts in order to ensure that they're remarkably rich and and decidedly chocolatey. Your dessert menu consists of: Dark Chocolate Ganache-Glazed Gluten-Free Brownie Bites with Marzipan Hearts; White Chocolate, Pistachio, and Matcha Mousse Pudding with Pomegranate Seeds and Mochi Waffle Garnish; Mocha Creme Brûlée; Gluten-Free Chocolate Chunk Cookies; Spice It Up Ginger Truffles; and Chocolate Jello Shots with Homemade Chocolate Vodka.
Visit http://recreational.ice.edu/Courses/Detail/15295 to register.
1 lecture/demonstration; 4 all-day hands-on classes
- Classes are limited to 14. REGISTER EARLY!
- A certificate of completion will be issued to those students attending the full 5 days.
- Fran's book is included in the fee.
If you're on a mission to make world-class vegan desserts, sign on for some "basic training" in the field. Learn the tactics involved in baking without dairy, eggs, and refined sugar, or odd ingredients. The entire operation was developed by Fran Costigan, vegan pastry chef-instructor and author of Great Good Desserts Naturally, More Great Good Desserts Naturally, and the new Vegan Chocolate: Unapologetically Luscious and Decadent Dairy-Free Desserts, the books considered the "bibles" of vegan pastry arts. You'll gain the confidence to adapt many standard recipes to delicious vegan versions, as you learn about foundational pastry technique and ingredients specific to vegan baking. Quality organic, seasonal ingredients will be emphasized, including whole grain flours, organic fair-traded sweeteners (both liquid and granulated), vegan gelatin (agar-agar), root starches, non-dairy milks, sulfite-free dried fruits, chocolate, cocoa, pure extracts, leavening agents and much more. Novice and experienced bakers and everyone in between will benefit from the expert training offered in this unique intensive. Plating of desserts will be practiced daily and a dessert buffet party will be our finale.
Visit: https://www.naturalgourmetinstitute.com/class/vegan-baking-boot-camp-intensive-day-1/ to register
A Main Street Vegan® Lifestyle Coach & Educator is a practicing vegan who is certified to coach, counsel and educate individuals and groups in adopting this health-promoting and compassionate way of eating and being in the world. As a Main Street Vegan-certified VLCE, you'll be qualified to help individuals and groups go vegan, stay vegan, feel terrific, and be part of the wonderful ripple effect that's saving the lives of people and animals, and helping heal the planet. In addition, you'll learn at the Academy how to set up a Vegan Lifestyle Coaching practice, market yourself, speak for groups and to the media, and make the most of the Internet.
Fran is an advisory board member and teaches at Victoria Moran's Main Street Vegan Academy.
The session is sold out, but a wait list is available. The next session is: June 5th – 10th.
Visit the Main Street Vegan website for more information: http://mainstreetvegan.net/academy/


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An Elkins man is being held in the Tygart Valley Regional Jail on $20,000 cash bond after being arrested on child abuse charges, police said.
Daniel Clifford Moore, 26, was arrested on one count of child abuse resulting in injury, a felony, on Saturday. Police received a report on Nov. 14 from the state Department of Health and Human Resources indicating that Moore had physically abused a 4-year-old girl, according to the criminal complaint.
The report indicated the alleged victim had gone to school with visible bruises and injuries to her face and neck area on Nov. 4, according to the criminal complaint. The report further claimed that the alleged victim has sustained numerous physical injuries as a result of abuse by Moore.
Article Photos
According to the report, the alleged victim "stated that (Moore) hit her." In the report the bruise on the alleged victim's left cheek is described as "dark purple with pulled blood to the bottom the size of an orange and starting from under the cheek and up towards the middle of the cheek," according to the criminal complaint.
The report also states the alleged victim "indicated to school staff that (Moore) had bit her," the complaint reads.
The report was accompanied by photographs of the injuries, which indicated an open abrasion near the alleged victim's left eye, the complaint states.
State Police officials obtained a copy of the emergency physician record form from Davis Memorial Hospital, which includes details of a medical evaluation of the alleged victim conducted on Nov. 5. The evaluation indicated the alleged victim was asked about the bruise on her cheek. She responded by making a fist and showing it hit her cheek, according to the complaint. The alleged victim also stated that her hair had been pulled and indicated that the marks on her neck were caused by choking, the complaint states.
During the medical evaluation, the alleged victim, for the third time, identified Moore as the person who had hurt her, according to the complaint.


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Wild ruminants burp methane, too
Wild ruminants burp methane, too
IN NORTH America, there are many native ruminants, that is, herbivore animals with a complex digestive system, a major compartment of which is the rumen. Some present-day examples are the bison (Bison bison), the elk (or wapiti, Cervus Canadensis), the deer (Odocoileus virginianus), or the mule (Odocoileus hemionus).
Vast herds of bison, by some estimates up to 75 million, roamed the prairies before and during the early settlement periods. As all ruminants do, these presettlement herds emitted methane, but the size of these emissions has rarely been estimated.
The common feature of all ruminants is the microbial fermentation and degradation of fibrous feeds occurring in their forestomachs, primarily the reticulorumen (the joint compartments of the rumen and the reticulum). The results of this fermentative process are products benefiting the host animal (microbial protein, used by the animal as a source of amino acids and volatile fatty acids, used as an energy source).
Rumen microbes, on the other hand, thrive in the "temperature-controlled," oxygen-free (the typical rumen microbes are anaerobes), substrate-rich environment that the host animal provides for them.
Not very efficient
Indeed, this symbiotic process is one of nature's wonders and has allowed ruminants to dominate the natural world. Ruminal fermentation, however, is not a very efficient process (at least from a biochemical point of view) and results in several by-products considered a waste, mainly carbon dioxide and methane.
Methane is a potent greenhouse gas (GHG), and domestic ruminants have been blamed by many for a large portion of the global GHG emissions, thus having a significant impact on climate change. The importance, or rather unimportance, of livestock to global GHG emissions has been discussed by us and by others (see Hoard's Dairyman, October 10, 2010 issue, page 622); here, we'll focus on wild ruminants.
Attempts in the past have estimated wild ruminants' methane emissions at around 41 to 49 grams per animal per day (which is about 0.8 to 1 kilogram of CO2 equivalent; the global warming potential of GHG is expressed as CO2 equivalents). For comparison, the average U.S. car emitted between 15 and 22 kilograms of CO2 per day in 2010 (go to http://1.usa.gov/Hoards-Car-Emissions).
Challenges in calculating methane emissions from wild ruminants arise mainly from: (1) population size is not exactly known and (2) emission per animal or per unit of feed intake is also not exactly known.
In performing the analysis presented here, we faced the same challenges and had to make several assumptions [for example, dry matter intake (DMI) for bison was based on the National Research Council's 2000 model prediction for a mature nonpregnant, nonlactating beef cow] and approximations to be able to compute wild ruminants' emissions for the United States in the past and present.
We used various sources for presettlement population sizes, body weight, feed intake, and methane emission rates. Mostly, population data are from the 2003 edition of the book, Wild Mammals of North America, the Rocky Mountain Elk Foundation, and Wikipedia.
A number of wild ruminant species, such as mountain sheep, goat, and antelope, for example, were not included in the analysis, mostly due to relatively small population sizes, that is, impact on methane emissions and lack of reliable population and feed intake data. Some species, such as moose and caribou, were not included because their habitat is primarily outside of the contiguous United States (Canada and Alaska).
Comparing then and now
In presettlement times, bison methane emissions represented between 84 and 93 percent of all emissions from wild ruminants (see Figure 1). Total emissions, depending on population size, ranged between 61 and 138 teragrams of CO2 per year. Overall, methane emissions from bison, elk, and deer in the presettlement period in the contiguous United States were about 70 percent of the current emissions from farmed ruminants in the U.S. That's the low side.
If the high bison population estimate (75 million) is taken for this comparison, wild ruminants in the presettlement period emitted as much methane as the nation's current domestic ruminants.
Present-day methane emissions from wild ruminants (excluding moose, mountain sheep, goat, antelope, and caribou) were also estimated. Body weight, DMI, and methane emission per unit of DMI were the same as for the presettlement calculations.
With these assumptions, it can be estimated that present-day methane emission from the major wild ruminant species in the U.S. are about 0.23 teragrams per year which is only 3.6 percent of the emissions from domestic ruminants. Due to its population size (estimated at 25 million) the white-tailed deer is the largest present-day wild ruminant contributor to GHG emissions in the contiguous United States.
Guest blog by Alexander N. Hristov
The author is an associate professor of dairy nutrition at Penn State University.


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For the 2012 Chevrolet Sonic, the idea of being more environmentally friendly isn't just about the car's EPAestimated 40 mpg on the highway.
The subcompact features a unique water-based "three-wet" paint process applied in a new eco-friendly paint shop with less environmental impact.
The process, in which General Motors is the first automaker to use in the US, eliminates the need for a primer bake oven, normally used between the primer and color-coating layers. The Orion Assembly Center (where the Sonic is built) allows three layers of paint to be applied one after another while still wet before a single trip though the oven.
This process reduces the paint shop footprint by 10 percent, providing additional floor space and reducing the energy needed to heat and cool these areas, notes GM officials.
No worries though, the "three wet" paint process doesn't affect the car's glossy sheen and durability long term.
"Cutting our greenhouse gas emissions and reducing our energy consumption were key to implementing our water-based 'three-wet' paint process," said Mauricio Pincheira, paint manager at Orion. "We want to provide a durable paint that impresses our first-time Sonic customers and maintain the tough environmental standards we have across the company." Orion's new paint shop was engineered to minimize energy use while reducing solvent emissions. By using the three-wet process, a thin film pretreatment, and exceptionally lean design methods, Orion's paint shop uses 50 percent less process energy per vehicle than the shop it replaced. It is also heated by natural and landfill gas, which results in less emissions than coal-fired boilers.
When full shift production is achieved, Orion's new paint shop will reduce greenhouse gas emissions by about 80,000 metric tons per year – equivalent to the annual emissions from 14,000 vehicles – and solvent emissions by about 108,000 pounds of solvent per year.
These paint process improvements also trimmed the manufacturing costs by about $40 per vehicle, making the Sonic a little friendlier on the pocket book as well considering every little bit helps.


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We have an export opportunity
We have an export opportunity
China isn't the only story. Other export markets are opening up as New Zealand focuses on meeting their import needs.
by Amanda Smith, Hoard's Dairyman Associate Editor
With a focus on the U.S. dairy market and exports today, in the coming year and in the long-term, Tim Hunt, Global Dairy Strategist with Rabobank, shared his insights on what the industry can expect. In future blogs, we will touch upon these topics, but two questions asked at the conclusion of his presentation highlight the potential for U.S. dairy in the export market if we position ourselves to be a bigger player.
During his presentation, Hunt briefly touched on what may happen when the European Union lifts production quotas in 2015 and was questioned further on this at the end of the talk.
"When quotas are removed, there will likely be production growth in northern Europe. This, in turn, will displace milk production in the higher cost regions of southern Europe. There will be some export growth, but it won't flood the market; opportunities will remain for the U.S.
"Irish producers are best prepared to take advantage of this with potential production gains of 40 percent by 2020. Many of these producers are running half dairy, half beef herds, since they cannot gain enough quota to become a full-fledged dairy operation.
"With their existing facilities, Irish producers are preparing to focus solely on dairy as quota is removed. They are prepared to expand their existing sites, but it is cost prohibitive, for most, to consider purchasing neighboring dairy and land. This will limit their growth potential in the future," noted Hunt.
He also commented that the Netherlands, too, have limited growth potential. "With expansion and additional cattle there is more manure. The country is close to or pushing the limit for the amount of manure it can produce on its land base.
"China isn't the only story," noted Hunt when asked if we can afford to place our export stakes on a sole country.
"Brazil, Russia, Mexico, Southeast Asia and other countries are beginning to import more dairy as well. These importers are expanding their demand; we don't have to rely on China.
"New Zealand relies on China as the base of its export market. As they have risen to meet China's growing dairy demand, they have pulled back from other countries and markets. This shift has left a demand gap for the U.S. to fill in countries that are closer to our boarders, such as Mexico and those in Latin America," he continued.
"The U.S. will always sell most of its product internally though," concluded Hunt.
The author is an associate editor and an animal science graduate of Cornell University. Smith covers feeding, milk quality and heads up the World Dairy Expo Supplement. She grew up on a Medina, N.Y., dairy, and interned at a 1,700-cow western New York dairy, a large New York calf and heifer farm, and studied in New Zealand for one semester.
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Legendary rocker Neil Young comes to Richmond's Landmark Theater on Sunday April 17 as part of his Spring Solo Tour.
Young will include songs from his currently acclaimed album, Le Noise, as well as his classic material in both acoustic and electric settings. Neil recently won his second-ever Grammy for "Best Rock Song" for "Angry World," a track from Le Noise, which was nominated for Best Rock Album. Neil Young has invited British folk legend Bert Jansch as support for his appearance here in Richmond. Tickets are available from TicketMaster .
Neil Young is a Canadian singer-songwriter who is widely regarded as one of the most influential musicians of his generation. Young began performing as a solo artist in Canada in 1960, before moving to California in 1966, where he co-founded the band Buffalo Springfield along with Stephen Stills and Richie Furay, and later joined Crosby, Stills & Nash as a fourth member in 1969. He then forged a successful and acclaimed solo career, releasing his first album in 1968; his career has since spanned over 40 years and 34 studio albums, with a continual and uncompromising exploration of musical styles. The Rock and Roll Hall of Fame website describes Young as "one of rock and roll's greatest songwriters and performers". He has been inducted into the Hall of Fame twice: first as a solo artist in 1995, and second as a member of Buffalo Springfield in 1997.


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on May 23, 2013 - 11:48 PM
Nobody knows where "Coco Chanel" came from, but the pig snared in a residential neighborhood by West Seneca police now is making herself at home at the SPCA Serving Erie County in the Town of Tonawanda.
Officers were dispatched Wednesday morning to Garry Drive on a report of a loose pig chasing after people. Using a snare pole, officers caught the pig as she approached them.She's believed to be a young Vietnamese pot-bellied pig, weighing 35 to 40 pounds.
SPCA farm manager Sheila M. Foss started calling the pig Coco Chanel, after her cocoalike coloring. The pig appears in very good health and is "very social," Foss said. "She's doing great here."
A domesticated animal used primarily for food, the pot-bellied pig has joined the ranks of household pets in the last few decades. Municipal zoning laws dictate where they're welcome.
"They do make a wonderful farm pet. Some people do have them in their homes," Foss said. But their size – they can weigh 100 to 150 pounds when fully grown – and household flooring eventually make that option less attractive. "Ideally," Foss said, "we find that a farm home works best."
Pot-bellied pigs are known to be highly trainable – to the point of using a litter box.
This pig's status at the SPCA is that of a conventional stray. Anyone with information on the pig or who's interested in adopting her, should call 875-7360.
email: email@example.com


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Ping 52: Nic Fillingham, Windows Phone 7, XNA and Channel 9 Live
- Posted: Mar 15, 2010 at 6:53PM
- 2 comments
Loading user information from Channel 9
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This week we welcomed special guest host, Nic Fillingham, who not only runs Channel 9 LIVE at MIX 2010 but also brings us these stories:
and Just For Fun: New Dork Music Video
Oops, something didn't work.
Hmmm. Flash is good.
Will Windows Phone 7 run the Photosynth viewer on http://photosynth.net, though? That's like the ACID3 test of the Silverlight world.
Of course... I wouldn't exactly shed tears of mourning to see a dedicated Photosynth app for Windows Phone 7 that gave iSynth a run for its money.
I heard this morning that Microsoft's Bing search engine will continue to censor search results in China. I am a huge MSFT fan boy, but Microsofts alliance with the government of China to suppress the spread of information is wrong to me. I am very conflicted on this.
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UPMC Teleconsult Centers are a new model of care, bringing specialty physicians close to home by utilizing state-of-the-art video conference technology.
When a specialist is not available in Seneca or Cranberry Township, the UPMC Teleconsult Center at UPMC Northwest brings the expert close to home, saving you the trouble of traveling to Pittsburgh.
Using HIPAA-secure teleconferencing technology and dedicated on-site staff, the UPMC Teleconsult Center connects you directly to specialists in Pittsburgh.
You and the expert physician can see and hear each other during your consultation, and medical staff at your location can perform an exam and share their findings in real time with the expert physician.
Important Note: Please contact your doctor for a referral to the Teleconsult Center.
Specialties available at this location include:
UPMC Teleconsult Center at UPMC Northwest100 Fairfield DriveSeneca, PA 16346
For more information, contact Jennifer Dueweke at 814-677-7456.
Affiliated with the University of Pittsburgh Schools of the Health Sciences
Supplemental content provided by Healthwise, Incorporated. To learn more, visit www.healthwise.org
For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.
UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, gender identity, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.
Medical information made available on UPMC.com is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, UPMC.com is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.
For UPMC Mercy Patients: As a Catholic hospital, UPMC Mercy abides by the Ethical and Religious Directives for Catholic Health Care Services, as determined by the United States Conference of Catholic Bishops. As such, UPMC Mercy neither endorses nor provides medical practices and/or procedures that contradict the moral teachings of the Roman Catholic Church.
Pittsburgh, PA, USA UPMC.com


text:
Source: Best Buy
quote: First off, Android doesn't have the best mobile UI, WP8 does.
quote: OMG, widgets!
quote: Second, apps are how we use hardware. They're how we view video, interact with websites, interact with businesses and services, play games, do scheduling, do finance, do everything.
quote: Kinda of tying yourself in knots to bash Android here. Because Windows Phone, which you constantly rank higher than Android, is still to this day seriously hurting for app development. And they are the last to get those "killer apps" usually.
quote: Again, there isn't a single thing you can do on IOS that you cant with Android. There are a ton of things you can do with Windows that you cannot do with Linux


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INCLINE VILLAGE, Nev. - Take a 20-year anniversary of the Incline Village Recreation Center, toss in a Mark Twain birthday celebration, add wine and what do you get? A night of wine and wisdom.For those who chose not to buck the blustery weather last Friday I shall unveil some of Mark Twain's secrets of longevity here and hope they are of some use to you down the road...Ostensibly, I am an old man now at 177, and I have known a great many troubles; most of them never happened. When I was younger man, studying for the gallows, I could remember anything, whether it happened or not. But I am getting old now, and soon I shall remember only the latter. I have achieved my 177 years in the usual way; by sticking strictly to a scheme of life which would kill anybody else. You cannot reach old age by another man's road.We have no permanent habits until we are forty. Then they begin to harden, presently they petrify, then business begins.In the matter of diet I have been persistently strict in sticking to things which did not agree with each other's company, and letting them fight it out on the inside. Though this past Thanksgiving I stopped frolicking around with mincemeat pie after midnight; up to then I had always believed it was not loaded.As for smoking, I came into the world asking for a light, and will probably go out blowing smoke rings. I smoke in moderation today; I never smoke more than one cigar at a time. Oh, it has always been a rule of mine never to smoke while asleep, and never to refrain when awake. It is a good rule. I mean for me, though some of you know quite well that it wouldn't answer for everybody that's trying to get to be 177 years old.I have always bought cheap cigars -reasonably cheap. Ninety years ago they cost me six dollars a barrel. But my taste has improved lately, and I pay seven now. Six or seven. Seven, I think. Yes, it's seven. But that includes the barrel. These were manufactured in Hartford for the clergy. They make noise when they burn ... like a forest fire crackling. The good news is, fleas and mosquitoes take no interest in me whatsoever.As for drinking, I have no rules about drinking; when others are drinking, I like to help. I have found that a tumbler full of whiskey in the afternoon is a preventative against toothache. I've never had the toothache, and I don't intend to have one.Exercise? Exercise is loathsome. I've never seen any advantage in being tired. Whenever I get the urge to exercise, I go lie down somewhere until it passes away ... forgive me for saying so on these hallowed grounds.In closing I repeat and emphasize my maxim: You cannot reach old age by another man's road. My habits protect my life, while they would assassinate you! The main thing, the essential thing, is that we endeavor so to live that when we come to die even the undertaker will be sorry. And that speaks to you, Mr. Galante.Thanks to the gracious staff at the recreation center and the folks at Tahoe Ridge Winery, we had the most sociable evening of wine & wisdom in recent memory...- Learn more about McAvoy Layne at www.ghostoftwain.org.
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December 3, 2012
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When G.T. "Buck" Smith became president of Davis & Elkins College on July 1, 2008, he announced a six-step philosophy he and the board of trustees have used as a guide during his tenure.
The "six Rs" were crafted to lead the college in a positive direction. Those guiding principles were: to reduce expenses, recruit students, retain students, raise funds, renew programs and reach for new opportunities.
"That's essentially been our strategic plan," Smith said in an interview Friday evening at The Inter-Mountain.
Article Photos
The Inter-Mountain file photo
Davis & Elkins President G.T. 'Buck' Smith will step down from his post June 30, but will continue to serve the college as president-emeritus.
As an example of the plan's success, he pointed to significant improvements in student recruitment.
"Recruiting increased by 50.5 percent in only one year," he said, noting the hike was driven primarily by the Highlands Scholar Program.
That scholarship is available to students - in the seven counties surrounding the college - who have a 2.5 or better GPA. Smith said there were 16 new D&E students from those counties in 2008. The next year, there were 87, and today, that number is 287.
"It (the scholarship) made it possible for students to go to college," Smith said. "If you are serious about getting an education, you can get it at D&E."
The program has become a keystone of the college's mission, he said.
Another accomplishment achieved during Smith's tenure has been fundraising. He said the college has raised close to $25 million in gifts in the past five years.
"The key here has been the generosity of members of the board of trustees, and people in the community, ... alumni, family and friends," he said.
D&E also became debt-free with Smith at the helm. After owing more than $10 million to the bank in 2008, those debts were paid off by Nov. 7, 2012, Smith said.
"We are among a handful of colleges in the country that have no outside debt," he said, noting he didn't want to take credit for the college's overwhelming success in the past five years, which included more than $10 million in campus improvements.
He said all members of the board "are the people who really transformed the college. I just got to be in a role to help their vision become a reality."
Smith specifically highlighted the work of Board Chairman Paul Stirrup, who "reported for duty" at D&E the same day Smith became president.
Working with Stirrup, June Myles and all members of the board of trustees was a true pleasure, Smith said, adding he also enjoyed working with the generous supporters of the college, including donor James McDonnell.
"Serving D&E has been the highlight of my life ... because of the people," he said. "D&E is such a positive, can-do place. You don't find that universally and throughout, (other colleges) don't have that kind of ethos. It's very special."
Another high note from his time as president was seeing the board of trustees recommend that the new softball field be named in honor of his wife, Joni. He called it "the most touching moment of my life."
He said she has acted as a mother to all D&E students over the past five years, and "you could count on one hand the number of sports events she has missed" in the past few years.
Affirming the positive direction of D&E, Smith said this time is a "renaissance in the spirit of hope and the possibility of the future, not only for the college, but also for everyone associated with the college, reaching the wider community."


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|The Surprising Appearance of Nanotubular Fullerene D5h(1)-C90
The previously undetected fullerene D5h(1)-C90—with a distinct nanotubular shape—has been isolated as the major C90 isomer produced from Sm2O3-doped graphite rods and structurally identified by single-crystal x-ray diffraction. Fullerenes are well-defined molecules that consist of closed cages of carbon atoms and distinct inside and outside surfaces. They tend to form very small crystals; consequently, high-resolution data was collected using small-molecule crystallography at ALS Beamline 11.3.1. The discovery of nanotubular D5h(1)-C90, which is a fullerene with 90 carbon atoms and D5h symmetry, opens a bridge between molecular fullerenes and carbon nanotubes.
In recent years, the well-known solid allotropes diamond and graphite have been joined by new allotropes: fullerenes, carbon nanotubes, and graphene. Diamond consists of four-coordinate carbon atoms with tetrahedral geometry, while the other allotropes involve three-coordinate carbon atoms. In graphite, these carbon atoms are arranged in hexagonal sheets that are stacked upon one another. Graphene is simply a single hexagonal graphitic sheet with a thickness of only one atom.
Carbon nanotubes can be conceived as hexagonal graphene sheets rolled into cylindrical shapes. These tubes may consist of a single wall of carbon atoms (single-walled carbon nanotubes) or may consist of multiple layers of tubes nested inside one another (multi-wall carbon nanotubes). Carbon nanotubes are produced as mixtures in which the individual tubes can vary in length, width, precise alignment of the component hexagons, and the chemical nature of the unique carbon atoms at the two ends of the tube. Graphene is likewise produced as sheets of varying size with generally less well-defined structures for those carbon atoms at the outer edges.
Fullerenes of varying sizes (from 60 to more than 500 carbon atoms) have also been observed, and individual molecules such as C60 and C70 have been isolated in pure form. Each fullerene is constructed of 12 pentagonal rings of carbon atoms and a number of hexagonal rings. For example, the prototypical C60, the most readily prepared fullerene, has 20 hexagonal rings in addition to the 12 pentagons.
Isolating higher fullerenes in an isomerically pure form is challenging, especially since the number of isomers increases as the size of the fullerene cage expands, as per the isolated pentagon rule (IPR). The IPR requires that each pentagon be surrounded by five hexagons to avoid strain-inducing pentagon–pentagon contact. There are 46 isomers of C90 that obey the IPR, but none of these isomers had previously been obtained in pure form. Indeed, in the absence of Sm2O3, no D5h(1)-C90 has ever been detected.
The oblong fullerene D5h(1)-C90 belongs to a set of nanotube-like fullerenes with the formula C60+10n, which have alternating D5h symmetry (when n is odd and the end caps are eclipsed) or D5d symmetry (when n is even and the end caps are staggered). The structure of D5h(1)-C90 (n = 3) is thus closely related to that of C70 (n = 1). However, within this family only C60, C70, and D5h(1)-C90 have been isolated in pure form and characterized crystallographically.
The isolation of D5h(1)-C90 provides a unique molecular model for carbon nanotubes that will allow scientists to explore the chemical and physical properties of a distinctly cylindrical fullerene. The armchair-style belts that are found at the waist of D5h(1)-C90 are a unique feature of this particular fullerene, but are the fundamental building block of carbon nanotubes.
Research conducted by H. Yang, A. Jiang, Z. Wang, and Z. Liu (Zhejiang University, P.R. China); H. Jin (Jiliang University, P.R. China); B.Q. Mercado, M.M. Olmstead, and A.L. Balch (University of California, Davis); and C.M. Beavers (Berkeley Lab).
Research funding: National Science Foundation and the Natural Science Foundation of China. Operation of the ALS is supported by the U.S. Department of Energy, Office of Basic Energy Sciences.
Publication about this research: H. Yang, C.M. Beavers, Z. Wang, A. Jiang, Z. Liu, H. Jin, B.Q. Mercado, M.M. Olmstead, and A.L. Balch, "Isolation of a small carbon nanotube: The surprising appearance of D5h(1)-C90," Angew. Chem. Int. Ed. 49, 886 (2010).
ALS Science Highlight #217


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The Benson/San Pedro Valley Chamber of Commerce is a vital force in the community. It seeks to unite all of the industrial, commercial and governmental interests for the purpose of concerted action in supporting those activities that are beyond the scope of any single business or industry and that promote the welfare of the Benson Community and the surrounding area as a whole.
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text:
Source: GOP
quote: Human Life, as in the kind that earns the protection of law, is based around the idea of human intelligence and human consciousness. We know that these functions are rooted in the brain, therefore an undifferentiated ball of cells certainly does not qualify.
quote: There is no biological argument that a zygote deserves the same legal protections as a grown human being. The only arguments for it are based in the idea that human sperm meeting human egg create/are granted a soul, which is a purely religious argument.
quote: A plant "learns" to spread its roots out and around solid objects in order to get more water, does that relate to consciousness or intelligence? It is still considered life. An amoeba has a single cell and swims around and has a purpose, a single celled life. So how is that any different than a human baby? It isn't.
quote: Same argument, life is life no matter if it has consciousness or intelligence. A human baby uses pre-programmed instinct for the first year of its life.
quote: Human reproduction creates another human, the fact that it is life as soon as the sperm and egg meet and will become another sentient human, even though it may not be for the first few months, means its ok to kill that life?
quote: You liberals really have a twisted logic. "Save the trees and fish and puppy dogs, not the humans!" You try to sound smart and then relieve us of that belief as you type...


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quote reign in hellyep mine too:)My fav tag tem has got to be 'Ling Xiaoyu and Jun Kazama
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LC-MS Gains Favor Due To the...
Wall Street Decline Takes Its Toll...
As Immunotherapy Revolutionizes the Cancer Treatment...
NSCLC is "Major Battlefield" as Merck,...
Aduro BioTech won two Phase 1 SBIR grants together worth more than $250,000 and has become a subcontractor to the University of New Mexico (UNM) on a $500,285 grant from the Defense Threat Reduction Agency (DTRA), all aimed at demonstrating applications for the company's vaccine platform. The technology is based on Listeria monocytogenes, which Aduro has reportedly modified to be safe for human use and to target specific molecules in tumors and infectious diseases.
In its collaboration with UNM Aduro will develop vaccines for tularemia. It expects to build on its previous success with vaccines expressing single antigens. The firm will develop vaccines that express multiple antigens to broaden the immune response.
The two SBIR grants are focused on HBV and melanoma. For the HBV work, Aduro plans on developing a therapeutic vaccine expressing multiple HBV antigens. The firm will be responsible for all preclinical development. The company won $188,315 from NIAID, with Peter M. Lauer, Ph.D., its head of molecular biology, as principal investigator.
Under the SBIR grant covering melanoma, Aduro will work with Nina Bhardwaj, M.D., Ph.D., professor of medicine, pathology, and dermatology at the New York University Langone Medical Center. The company won $70,847 from NCI, with Dirk G. Brockstedt, Ph.D., Aduro's vp of R&D, as principal investigator.
Aduro will be responsible for developing a clinical vaccine candidate that expresses two melanoma antigens. Dr. Bhardwaj will evaluate the immune response generated by the vaccine in multiple models. If the preclinical program is successful, Dr. Bhardwaj is expected to be the principal investigator for the Phase I trial.
The SBIR grants and the UNM contract are part of $20 million in funding received by the company for its Listeria platform. The platform has been in development for nine years and, according to the company, has been validated by studies in more than 20 major publications.
The firm's lead attenuated Listeria vaccine, CRS-207, is engineered to express the tumor-associated antigen mesothelin. In December Aduro announced Phase I results from a study conducted in in 17 end-stage patients with cancers known to express mesothelin: mesothelioma, non-small-cell lung, ovarian, and pancreatic. Analysis after the completion of the trial revealed a mesothelin-specific T-cell response in multiple patients. Despite an expected survival of 3–5 months for all subjects, six out of 17 lived 15 months or longer.
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Thursday, July 17, 2014
Filing for Dorchester District Twos board election ended at noon Tuesday.
The potential candidates for this years election are Justin Farnsworth, Evan Guthrie, Gail Hughes, Brian Mitchum, Tanya Robinson and Lewis Smith.
There are four seats available.
Election Day is Nov. 4.
Board members are sworn in at the next board meeting after the election, Nov. 10, and will take their seats immediately.
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James Franco, who's up for an Academy Award for his work in 127 Hours, is returning to ABC's daytime drama General Hospital as performance artist Franco.
The actor, who is also hosting the Oscars with Anne Hathaway, will appear the soap on episodes airing Feb. 25 and Feb 28 (at 3 p.m. ET) to "wreak havoc" on the fictional town of Port Charles, according to a release from ABC, and to "make an important phone call to his nemesis Jason Morgan" (played by Steve Burton), who appears in a behind-the-scenes shot with Franco.
Following a two-month stint on General Hospital in 2009, Franco reprised his role as the mysterious and dangerous artist in the summer of 2010.
"Working on General Hospital was a great experience," he told PEOPLE at the time. "I love the cast, writers, directors and producers. They have become a new family for me."
Rick Rowell / ABC
See what other readers have to say about this story – or leave a comment of your own


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on February 13, 2013 - 9:48 PM
, updated February 14, 2013 at 9:02 AM
Just a day after hundreds of gun rights advocates rallied in Albany against Gov. Andrew M. Cuomo's new gun-control law, others affected by the strictest-in-the-nation regulations weighed in with objections of their own at a hearing Wednesday in Buffalo.
And many of those objecting probably don't own guns.
Mental health advocates expressed concern over the legislation's less publicized provisions, such as requiring doctors and counselors to report potentially violent clients to the state. That's a serious breach of doctor-patient confidentiality, they said.
"This was very hastily prepared and not robustly considered legislation as it could have been from many dimensions," said Kenneth P. Houseknecht, executive director of the Erie County Mental Health Association.
Beyond that, he said, too many fingers are pointed at the mentally ill, following tragedies at Newtown, Conn., and elsewhere where gun violence has taken lives.
"We have to stop associating violence with mental illness," Houseknecht said. "This is the most insidious stereotype we perpetuate."
Houseknecht and others testified at a hearing convened by Assemblywoman Jane L. Corwin of Clarence and Sen. Patrick M. Gallivan of Elma. Both are Republicans who voted against the Cuomo bill last month. They were joined by other Republican and Democratic legislators who voted against the bill.
Though the legislators heard from critics such as Sheriff Timothy B. Howard who reiterated Second Amendment concerns, the testimony by Houseknecht and others took a different tack.
He pointed out that 1 in 4 Americans and about 250,000 people in Erie County deal with mental health issues, while only 4 percent of violent crimes are attributed to the mentally ill.
The NY SAFE Act, he added, may actually discourage people with mental problems from seeking treatment because of new requirements for health professionals to report potentially violent clients.
He also quoted extensively from an opinion article published Wednesday in The Buffalo News by Dr. Steven L. Dubovsky, chairman of psychiatry at the University at Buffalo School of Medicine, who echoed the same arguments.
Mental health provisions of the new law should have been considered separately, Houseknecht said.
"Unfortunately, when you put [separate aspects] of the bill together, there are unintended consequences," he said. "You 'disincent' people who need help and impair the patient-professional relationship in ways that were not fully thought out before passage of this law."
The panel also heard from Peter Faustino of Westchester County, immediate past president of the National Association of School Psychologists. He called for increased access to mental health and support services for the 1 in 5 adolescents with mental health disorders.
He also said cuts in Medicaid have resulted in fewer services for at-risk students.
Erie County Clerk Christopher L. Jacobs registered his objections to the law, also veering from familiar Second Amendment issues. But he did emphasize that county residents could now encounter a significant waiting period for pistol permits to be approved.
Fears over the new law's consequences have produced a quadrupling of permit applications in his office, he said, and relicensing and Freedom of Information Law requests will put undue burdens on county clerks across the state.
"This new state law imposes a significant cost on the local taxpayers – the definition of an unfunded mandate," he said.
"Or alternatively, the workload becomes so unmanageable that it becomes essentially impossible for a law-abiding citizens to obtain a pistol permit within a reasonable period of time – thus, a direct infringement on a constitutional right."
Wendy J. Roberson, Niagara County deputy clerk, added that the waiting period for approval of pistol permits could extend from the current four months to between six and 12 months.
"Either the cost of government will increase or the efficiency of government will decrease," she said.
Howard repeated the objections he has sounded in recent weeks about the law, criticizing the hasty manner in which it was adopted as a result of what he called Cuomo's political objectives.
"I believe the governor rushed legislation and squandered an opportunity to enact meaningful legislation for the safety of our communities just to be the first and the toughest – for his own personal agenda," the sheriff said.
"He capitalized on the hysterical following several tragic events. This legislation was reckless and irresponsible."
Other legislators at the hearing were Republican Assemblymen Raymond W. Walter of Amherst, John D. Ceretto of Lewiston, Joseph M. Giglio of Gowanda and David J. DiPietro of East Aurora, as well as Democratic Assemblymen Dennis H. Gabryszak of Cheektowaga and Michael P. Kearns of Buffalo.
email: firstname.lastname@example.com


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President Abraham Lincoln dies, the "unsinkable" Titanic sinks, Jackie Robinson breaks baseball's color barrier, George C. Scott rebuffs the Academy Awards, and bombs explode at the Boston Marathon, all on this day.
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