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Quadruple Helices Appear To Have Role...
Process Development Jobs Still the Most...
As Immunotherapy Revolutionizes the Cancer Treatment...
Wall Street Decline Takes Its Toll...
A protein known as gp96, sometimes referred to as the immune system's "Swiss Army Knife," holds promise as a vaccine that directs cytotoxic T cells to target cancer. [University of Miami Miller School of Medicine]
For decades, immunotherapy seemed a tantalizing—yet maddeningly elusive—alternative to toxic treatments for cancer consisting mainly of chemotherapy and radiation therapy. Manipulating the immune system proved to work on certain allergies and microbes, but immunotherapeutic cancer vaccines historically overpromised and underdelivered.
It wasn't until 2010 when the FDA approved Provenge for prostate cancer that immunotherapy gained status as a true contender for treating cancer. More recently, the realization that tumors require both immune evasion and active immune suppression to proliferate has fueled two successes so tremendous that certain pharmaceutical companies have entirely rebranded themselves as centered on immuno-oncology.
The first triumph involves a class of so-called "checkpoint inhibitor" drugs, including Yervoy and Nivolimumab. These checkpoint inhibitor drugs essentially take the brakes off the antitumor immune response and have generated dramatic clinical results in certain patients with advanced cancer. The second triumph involves a class of drugs that overcomes the evasive nature of tumors through engineering of patient-specific killer T cells, the body's innate enemy of cancer. Known as "chimeric antigen receptor" or CAR therapies, these drugs have yielded unprecedented clinical efficacy in a small group of patients with certain blood-borne cancers. Both types of drugs underscore how the human immune system—and specifically killer T cells—are fully capable of recognizing and destroying even very large masses if they are educated and delivered against a tumor with compromised defenses.
As the synergy between immunotherapy drugs builds, vaccines that direct cytotoxic T cells to target cancer are the first order of business. In this area, a protein known as gp96, sometimes referred to as the immune system's "Swiss Army Knife,"1 holds much promise. More than any other known natural immune stimulant, gp96 appears to have evolved specifically to educate killer T cells about cancer cells.
Gp96 is the carrier molecule for tumor-specific antigens that play a critical role in awakening killer T cells. The utility of gp96 as an immune stimulator stems from its unique ability to identify the full molecular fingerprint of cancer, flag tumor targets for the immune system with extraordinary efficiency, and deliver them exclusively to killer T cells. Normally ensnared within cells, gp96 can be untethered though a process that transforms it from observer to combatant. The result is a molecular warning system that heralds the presence of malevolent cells. Once injected into the body, secreted gp96 provides critical intelligence to killer T cells, teaching them how to seek and destroy cancer. In contrast, most prior and many current approaches are limited to a small array of tumor targets, require enormous doses to achieve immune stimulation, and inappropriately target the immune response that evolved to defeat bacteria—not cancer.
The saga of developing a drug that effectively and efficiently harnesses the power of gp96 highlights the differences between an autologous versus allogeneic approach. Autologous drugs are derived from patient-specific tumors, making the treatment highly personalized. While this path has the potential to be effective, it is also enormously costly. The failure of Provenge, for instance, to become a significant immuno-oncology product is due to a combination of limited efficacy, inherent drug complexity and high manufacturing cost.
Allogeneic drugs, in contrast, may be mass-produced at much lower cost and hold potential to be equally if not more effective as their autologous cousins. By utilizing laboratory tumor cell lines developed from specific cancers, an off-the-shelf drug can be efficiently delivered to a vast patient population—offering a unique and highly differentiated way to treat a wide range of cancers.
An allogeneic approach to engineering vaccines to secrete gp96, together with a complete repertoire of tumor targets that stimulate killer T cells, is fully scalable. Moreover, the continual emission of gp96 proteins offers a natural "time-release" delivery system that may have significant therapeutic potential.
Allogeneic tumor vaccine approaches are possible because tumors are known to share immune targets with one another. In developing a secretable gp96-based vaccine, it is critical to select an appropriate tumor type and an appropriate cell line that expresses an array of tumor targets known to be shared amongst a high proportion of patients with a given tumor type. The specific response of patient killer T cells against those predetermined tumor targets can then be monitored in patients, and has been shown to correlate with overall survival following treatment with gp96 secreting vaccines.
The promise of this technology extends to a broad range of tumors including orphan cancer indications, or in patients whose response to the toxicity of traditional chemotherapy limits the duration of therapy. In addition, this therapy can be utilized by patients with good responses to initial surgery or therapy but remain at very high risk of relapse.
Immunotherapies will continue to hold promise as a growing number of cancer vaccines combine with an allogeneic gp96-Ig approach. As clinical studies in this area progress, evidence will mount demonstrating the benefits of this variety of immunological manipulation, and whole-cell cancer vaccines that continually secrete gp96-Ig will increasingly gain the attention of pharmaceutical research teams progressing cancer remedies into the marketplace. Eventually, tremendous synergy in immunotherapies will enable combination treatments that will truly transform the landscape of immuno-oncology.
Taylor Schreiber is a senior scientific advisor to Heat Biologics.
References:1 Schild H & Rammensee H, gp96-The Immune System's Swiss Army Knife. Nature Immunology 2 100–101 (2000)
Taylor Schreiber is a senior scientific advisor to Heat Biologics.
References:1 Schild H & Rammensee H, gp96-The Immune System's Swiss Army Knife. Nature Immunology 2 100–101 (2000)
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The start of the new year brings with it a bit of sad news as one of our gardeners here at CUH has decided to take another position that's full time, leaving just two half-time gardeners to oversee the grounds here. With our staff so limited as it is to oversee all aspects of the work we do and a budget that's going to see more cuts, getting a new gardener sometime soon is highly unlikely. So, we certainly have challenges ahead of us, but we move forward.
January has traditionally been the coldest month of they year, but with our cold snap of November and drab December, I'm just praying that we don't endure anymore severe fluctuations in temperature and prolonged subfreezing temperatures. So many plants have been hit and we're all just waiting for signs of spring to distract us from our worries. Luckily, daffodils are showing signs of life as are the lovely Hellebores we are most excited about watching bloom in the next couple of weeks! You might remember 'Josef Lemper' from last year along with 'Jacob', 'Pink Frost' and the highly anticipated 'Walburton's Rosemary'. Then come the x hybridus selections that will be standouts in the Soest Garden for sure!!
We've also been trying to plant, if soil allows us so, and our focus has been getting our vine collection out of the nursery and into the grounds of CUH. Several grape species (Vitis) have been installed to clamber around the Southwest side of Merrill Hall and a few Clematis species climbing or carpeting the slopes of the Stormwater Garden. They've been mulched well in the hopes they survive the transplant well and establish as quickly as possible.
The McVay Courtyard will undergo a bit of a facelift to help spruce up the site with the addition of a new maple tree, flowering perennials and bulbs and the relocation of a large specimen of Edgeworthia chrysantha that will need to carefully be dug and transplanted to two possible locations. You might recall this plant suffering from the cold last month, so we will try and find a more sheltered location for it.
Now with more snow in the forecast, we have to pace ourselves and pray we get everything we want to get done, accomplished. It's mother nature; you always have to try and work with it, never against it!
I'm sure it'll be forgiving, it always seems to be.
Think spring….and tell it to hurry!!

subset: commoncrawl


text:
Nikon Coolpix S9100 Review
Latest Camera Reviews
Panasonic Lumix DMC-G80 Review
Your Comments
108 Comments | Newest Oldest First | Post a Comment
The battery needs to be in the camera whilst charging. That is just dumb. I'll stick to the Sonys thanks…
At wide ,only the centre look good.
No thanks,At 300€ you can get for an little more the Canon S95 Even at an lower prise the Olympus SP800
and this camera give better pictures to.
If the wide pictures are not good,why bug for an 18X zoom.
I have to amid I hoped for better results at the wide end.
Thank you for the wonderful review :)
I am looking for a point and shoot for backup and I thing this is a good one.
Glad to see Nikon is finally making point and shoots which are competitive and worth buying.
I've actually been looking at this camera as my next purchase. How does it compare to some of the canon cameras in this same price range?
Your reviewers should learn grammar and spelling. They all sound like idiots!
As to the review itself, it was very informative and helpful. I would like to see a summery critique of the image quality,...pros and cons etc. Additionally, comparing the new S9100 to the old S8100 would be very informative. I am trying to determine if I should upgrade from my S8100 while I can still return it.
Looks like a nice camera… but a bit expensive… surely after a while price will go down.
I'm confused. How come the Pocket Lint web review of this camera has the identical picture of a manor house with a tree prominently showing in the foreground?
Frank Stanton,
Nice catch… I suppose you talk about photo 12, however they are not the same photo (framing is not identical) :]
Remember, #6 Robert, when you point the finger at others, three fingers are always pointing back at you.
You wrote: "Your reviewers should learn grammar and spelling. They all sound like idiots!"
Have you ever considered that English might not be their first language?
Also, you wrote that you would like to see a "summery" critique. I suppose you meant to write "summary" (unless, of course, you desire a critique written during the summer).
As for Robert.I hope his dutch and Frans is as good of my English.
Otherwise bug some one els.
What a shame that the 'main rivals' list is well out of date!
The current Fuji travel zoom is the F550exr, for instance
I wish Nikon had improved the night shoot mode. S9100 takes better pictures at night than its predecessor, but it is still worse than some of its competitors (see Sony CyberShot DSC-HX5).
Image Quality is good but I think color could be more enriched But one thing is for sure Nikon is really ahead in Higher ISO Management
Thanks For the In depth Study
Is there anyone else out there who would rather more cameras gave us better basic functions, aperture, shutter priority, manual modes, rather than a glorious array of seldomly used scene modes? How often do we use soft focus, food, punk, fish-eye? This goes for many top end compacts, especially Olympus. I fear that, along with high megapixels, this is more about a short term fad, designed to catch a consumer's eyes, rather than be of day to day use.
I agree with Roger! I'm dying to read something about the Fujifilm F550EXR! The specification is pretty cool, but I'd like to know something about the actual image quality as this is the No.1. priority…
Pls guys, give us a nice review! :)
Bee Jay,
Most of the companies limit their firmware to some extend mostly to point users into more expensive cameras (that feature almost the same hardware).
Then there is the marketing hypes ...
For most users 6MP's would be enough, and with current technology you could probably get clean ISO 800 if the cameras had such resolution.
To put more and more zoom without increasing the size another trend has appeared, cameras now have tiny sensors, add the extra mega pixels and you end up with really small photo-sites.
RAW capability is something that could be enabled in almost every camera (in some doesn't make much sense). Manual modes follow this like of though as well.
However not everything is bad, while they have very high pixel densities, many show us good results, and some of those creative scene modes offer stuff that would otherwise be impossible due to a lack of manual controls, fish-eye, in some cameras - I should add, in very few, shows a wider angle view that is basically the raw data without distortion corrections being used, night/firework modes allow you to access longer exposure times.
But yes, most of the time is hard to understand why to put useless modes when it would be a lot better if the user knew how to use the camera. You just need to understand what Focal Length, Aperture, Shutter Speed and ISO do to an image… it's not like one needs a PhD. to learn that.
I agree with Roger. Pls, pls, give us a nice review on the Fujifilm F550 EXR! The specification is pretty cool, but what about the actual image quality?
The Coolpix S9100 is a great camera at a great price. I remember buying the D1 and this has better file sizes! Grant
As your review notes, this camera has a 4x3 rear screen - and, as far as I can see, with no option within the menu to set the frame to a 3x2 view. Is this some kind of joke? Totally unacceptable from any Nikon, not least a "high end" one like this.
This is a great camera which is small enough to carry in your pocket and still gives top class low light images and high speed focus and shooting nearing that of a DSLR. The sensor is quite good and in my opinion the fuji EXR's are not as good or better at all in any way.
For this money S9100 is the best till date. Its the type of camera which you would love to carry on a holiday with family and make great videos also with it too!
bought this camera just a month ago, It worked for a week then the autofocus motor just kept buzzing and running non stop from the moment you turned it on, other that that the picture quality for a family pictures type camera were fantastic, crisp, sharp, excellent colour rendition and fast enough focus for shooting the kids, I just felt that in my hands the build quality was a bit iffy, I took it back with the fault and traded for a P300, and what an incredible little discovery that turned out to be.
I really think the S9100 would be a great camera. I wish it was a tad more thin, but the zoom range is awesome! My other pic was teh Cannon S95 but that's another 100 bucks and I don't see myself spending all that time tweeking manual settings on such a tiny camera with a limited zoom. Yep, it's going to be the S9100. My old Nikon L1 has been a great camera with excellent image quality, and still holding up well in spite it's bulkiness and slow operation. .... so I'm pretty much sold on the Nikons!
Hello everyone.
Please advice, I want to buy a new digital camera.
Look at photo quality. Not features, not add-ons, stuff.
The technical quality of the pictures for me, counts only.
Sharpness, colors, white balance.
I like some model.
Nikon s9100 - beautiful, wearable.
Sony wx5-small and neat.
Canon sx is 220/230
Nikon P300
May they all be the same matrix cmos-bsi.
Please that someone wrote me an email, which of these cameras,
offers the best quality pictures.
Does nikon s9100 is successful? doing a good photograph?
Is the P300 a s9100 or wx 5 or canon sx220-will be the difference in image quality?
My mail fotoartysta-monkey-wp, pl
Thank you and best regards.
#24 photo,
That is not an email…. at least one I can decipher…
I suggest you look at samples from several websites, learn what aperture, ISO and exposure time does to a photo (this is important to assert if the photos were well taken).
If you're thinking in video, check video samples as well… avoid youtube as it compresses the videos quite a bit.
Then, from the ones that please you most, check the features, ISO, exposure and aperture, as well as stabilization effectiveness. Interface speed, focus speed and photo to photo time are also interesting points.
Check the gimmicks, some cameras have panorama stitchers built-in or high speed video, others may have RAW, multi-aspect ratio sensors or other advanced photography stuff.
If possible, check the ergonomics and keys layout… some cameras are just impossible to hold and use. I have big hands so this is often a problem that troubles me.
Last, but not the least, check if that camera gives problems, foruns are a good source of information, but be wise in the way you read that information.
Join everything together and assert what is the best for you… PhotographyBlog and other websites help one to know a camera better, but then cannot replace the experience of trying one.
If you want to check the features in a easy way, google for snapsort…
Good luck!
Couldn't take your review.
It reads like a company ad or tech run down.
Nothing personal nor honest reviews.
Skimmed over it all and that was a waste!
You have your fans and some of them gave better reviews!
I can't understand how this camera gets such a high overall rating at such a high price. Low on features, excessive smearing at ISO 400 and up, soft edges and bad focus at the long end. Somehow it gets an overall score equal to it's highest catagory score, while other brands get an overall score equal to their lowest catagory score.
Review score - 2.5.
Nikon love score - 5.
Overall score - 5.
Ron #27
I have to agree. Four & a half stars?? I'm in the final stages of looooong shortlist research and I'm pretty sure i'll be getting a Lumix TZ9, but this review caught my eye as so many have done before :-/ At first this camera looks promising, but 4 secs max exposure? For £250+? Ok, you could probably just about make do for night shots at higher ISO (which admittedly looks good to me, at least in the review shots) but why should we have to? Would it really have killed Nikon to be just a bit more generous? Even a measly 8 secs would be a big improvement, and many much cheaper cameras go higher than that. And no manual modes, not even humble A or S priority.. Sorry PB, but it's reviews like this that made me gradually lose faith in review sites.
I have recently bought S9100 and I would like to say that I am absolutely not satisfied with the quality of the images it took. Always blur and not focused snaps are there. I took my s9100 to Nikon authorized service center but they are saying that this camera has no problem. Despite my all afforts I am not able to take crisp and clear images. When you crop the image to 100%, you will always fond some blur and snow over there.
Nikon 9100 is not so good.
Photo's, taken in bright very sunny daylight, are great. Zooming to the (optical)max also still gives good photo's.
Stabalizing at full zoom is super.
But .. when daylight is heavy clouded, quality drops significantly. Blur, not focussed, lots of noise.
Night pictures, or photo's in a medium lit room pictures without flash are simply bad.
And then video .. How can it be that video is showing more than 0.5 sec. delay than the audio?
Also, why is the microphone on top? The video is at the front, so should be the mic's. Now you hear more sounds from around than from what you're filming. Too many photo's and all video's on Nikon 9100 are NO fun to watch.
For me the Nikon Coolpix 9100 failed.
I bought the 9100 for $260 US. Cheaper at Walmart
I think the high score was because the pictures look good. There are plenty of cameras that have good specs, maybe better, where the pictures are disappointing. Anything that includes the word "waterproof" or example.
If you like the "Nikon look", then you will like this better than the Canon SX230. If you don't care for Nikon, then check out the Canon pictures and see if you prefer those.
I have Nikon coolpix s9100. Recently my employe purchased one 3mega pixel and 3 x zoom Samsung camera for just 60 dolar. I am surprised to see the amazing crisp and clear images taken by him with that samsung camera. Nikon make simply fool. By comparing result from both the camera i was feeling like cheated by nikon.
Hell with Nikon's long experience, Nikon is much behind then there competeters.
Thank you for this wonderful site! It's helped me to decide between the 3 cameras I was considering (Nikon's L120, S9100, and P300). I decided on the S9100 :)
I have been a very happy owner of a Nikon S8100 for the past 6 months and 3 days ago I received the new Nikon S9100. In some foruns I found negative comments from S8100 owners about the S9100, I'm sorry to say they were right. The S9100 is not bad at all, but the S8100 is one of those rare almost perfect cameras. The problems I found were focusing speed and precision and macro mode. The 18x lens don't work as well as the previous 10x. I really would like to have the effects and the sweep panorama of the S9100, but they are not worth the shortcomings. I was anxious to update the S8100 and bought the Canon SX230 and now the S9100, but they are not match for the outstanding Nikon S8100.
I love my s9100 with the 18 zoom and special effects but after 2 months it as broken,it switches on but does nothing and won't turn off, I hope this can be fixed. The pictures are so clear and close ups are easier and brilliant
God bless those who choose Nikon s9100. In night s9100 go blind and give full of snow images. In day light, like a drunk man it takes photo. where is focus point GOd knows.
I love the camera. Image quality is good and the zoom works well once you get used to it. The problem is that after having the s9100 for a month it froze up. Over the next day all sorts of quirky problems developed: not turning on, not shutting off. the zoom extending all the way out without any prompting, erasing pictures, etc. I intend to bring it back and get another, hoping it is a firmware problem.
Good Job Kym Crowley!
Little do you know your Sony battery charges the same way LMAO!
have taken more than 2000 pictures and 30 min of HD video, no problems, wonderfull shots, l like most the Bright Black&White; setting.
I added 2 extra batteries and a low-priced off-line AC battery loader.
For travelling i got kensington K33403 (wall/car/air) AC supply with extra USB load, so i got 1 PS for notebook and extras (phone,camera etc)
I was thinking of getting this cam cause of the zoom and HD video, but the night-shot where there is heavy grain and extreme amounts of smear(look at bricks and sky) convinced me not to.
My Samsung L210 gets better night shots than this..and it's old and sales for $75, it has better stabilization too at even no zoom.
These samples and review convinced me to buy a Sony HX9V instead, they seem to be on top of the CMOS compact game, I just have to lose 2x zoom, but gain features and better quality. Kodak, Pentax, Canon, Olympus and others couldn't match the features&quality; without a bulky body and sky-high price..
I also saved $80 while getting better quality in my choice..
This comment is for other readers..writers here get paid six figures whether they read this or not..and I'm not famous or rich.
Maybe write reviews that don't look like the writer was scared to have an opinion also..this is a staggering-boring trend on review sites..Nikon won't kill your family if you say they are selling low-ball designes high-ball..
I bought this camera in March 2011… and while it takes beautiful pic…NIKON has had my camera longer than I have!! My first one had to be repaired 2x due to freezing up…so NIKON sent me a brand new S 9100….which I have had for 1 week…and now this one doesn't do a thing!! Camera totally freezes up…I can't get a refund from the store…I am hoping NIKON refunds my money….I am truly disappointed because I love the pis I was able to take with this camera
Just had to return my Coolpix S9100 after only four days of use! It froze up on me on the Fourth of July, totally ruined my vacation! I had to keep popping the battery release to reset and take a picture…..one at a time. I have been reading other reviews and see we have all had the same problem….MAJOR GLITCH!! I'm now purchasing the Sony Cyber Shot DSC HX9V, comparable but, dependable!
Same problem here. Brand new S9100 completely freezes up occasionally(approx 1/50 shots) while adjusting zoom. Have to remove battery and re-insert to reset. Fortunately images have been retained so far, but quite annoying as I'm in Europe on vacation. Will return camera to dealer upon returning to the US. Except for the freeze-ups…very pleased with camera.
Same problem here, and we're on a 6-week vacation across the U.S.! It's not ruining our vacation, but it's terrible. We still have a few weeks to go and I have to wait until we return home before we can do anything about it!
I'm having the same problem with the camera freezing up occassionally when adjusting the zoom. It started on my first Nikon S9100 after a few weeks of use, and then quickly became so frequent as to make the camera unusable. The great store I got it from (Mike's in Denver) immediately gave me a new one, which did OK for a few months of on/off use. Now today the SECOND camera started displaying the same problem.
I too am experiencing the same frustrating freezing issues with this new camera. Ii bought this camera late May to take with us to Europe - within 2 weeks it was freezing up on us and wouldn't take a photo nor turn off. Crazy and totally unacceptable given the high end price tag on this camera. What a disappointment. I need to contact Nikon to have something done. It doesn't sound like fixing the camera is a viable option.
Brand new S9100 completely froze up after 4 days of use while on vacation….I have to get back to the store and get it replaced…hoping for better luck.
FINALLY… after several months of problems with the Nikon S9100 freezing up and NIKON refurbishing it/returning it to me/giving me a new one… I finally received a FULL refund from Nikon for my purchase price. I am truly disappointed as when it worked the 9100 took beautiful photos and I loved the Zoom capabilities. I will be looking into a replacement now… any suggestions?
To Jeannine
I'm shocked by the many problems with Nikons, could it be post earthquake/Tsunami models ? Even though they are not assembled in Japan, I'm sure that many components are made there and Nikon plants were seriously affected. I had the S9100 to substitute the wonderfull S8100 and I had no problems with it in terms of malfunctioning but it's much inferior to the S8100, so if you want to try it you will be very happy. I have also the new sony HX9, you can check the review here, it was rated as essencial (5 stars) and I agree.
Got this camera in May and just started getting the freeze issue. I was on vacation when this started happening. Looking at all the post above me I have concluded that you can't take this camera on vacation with you. It will freeze up.
Got it at Amazon and will now begin the return/refund process. I bet Nikon will not fix this problem. Great Camera when it does not freeze up.
It is sad that one can get hung up on the grammar and Gavin's writing skills instead of paying attention to the valuable contents of this review of S9100. All his efforts are very much appreciated. I had a Panasonic Lumix TZ5 and needed to upgrade. After reading this review, I ordered S9100 and I love it. Remember it is a point and shoot camera, and not a DSLR. Perfect for what I want to do with it. For the price (Amazon US), this camera is worth it.
The camera comes loaded with features with the 18x optical zoom being its USP but inexplicably it just freezes up without a reason.You could be taking a snap on the auto mode or the scene selector mode or the night mode or maybe operating the full HD video and bang in the middle of it,the camera is dead-something like a laptop or a computer hanging up in which the only solution is ctrl+alt+del…Regrettably nikon doesn't has those buttons and believe it or not you have to take out the battery and reinsert it again for the camera to regain its consciousness..Its something like Tony Soprano passing out in "The Sopranos":)
I bought this camera because my first digicam was a nikon which I bought in 2005 and still use without a problem..and I love the natural image quality of it..Alas the mighty have fallen and how!!!
I want a refund and not a replacement because after researching on the net I have found hundreds of similar cases whereby even replacements of the same model S9100 have been having the same problem.Nikon R U LISTENING!!!
Nikon S9100. My review…
For such a great money I spent for it (400EUR) it does not deserve any praise. The quality of the pictures is very poor. I tried to set the focus in different ways with no results and finally set it as default but the same poor quality in any situation.
I full sun daylight, the quality seems to be good, but in any other light lower intensities, the qulaity of the pictures is low (the focus is bad bad bad !!) and the image looks like blured.
Itried even with greatest resolution 4000x3000* .. not worked.
If you ask me ... buy other cameras for such a great amount of money.
For $270, this camera is a must have.
I am highly confused between Sony CYBER SHOT DSC HX9V and Nikon S9100. Which one is better amoung these in terms of image quality, video quality, night shots and features? I need the camera for some casual clicks and not photography stuff.
Plz Help
To Sunny
There`s absolutely no doubt that the HX9 is much superior. The Nikon S9100 was a big disappointment , and my model did not have the many quality issues that people are complaining here and in other forums. Everything in the Sony model works perfectly, focus, low light, HDR and the movies are breathtaking even in low light. Just read the reviews and opinions about it, absolutely superb.
Own one and I regretted it. After just 6 weeks the camera continually froze. Had to remove battery to re boot the camera to get it to work. Retail store does not want to know about the problem nor does Nikon Lidcombe Sydney. Clearly has a electrical problem.
Bought one on the 11/4/2011, and it failed on the 6 weeks later. Camera Freezes up at different times, similar to a computer and requires to be rebooted similar. That is remove the battery and replace it than it operates o.k. for awhile and the same problem occurs again. The ratailer and Nikon don't want to know about their responsibilites of warranty. I suggest go for another brand in this cameras specs.
@Fabio:Thank you so mch.I am done with researching.Going with Sony DSC-HX9V.As i am not a professional so speed will nvr bother me in a camera.
Thank You
Good decision Sunny ! Go for Sony :). Nikon 9100 is a real failure.
I have owned my s9100 for about six months and absolutely love it. I am not a professional photogragher and I still find the camera easy to use and I get GREAT pictures with it. I feel most of those that don't like it, have human error problems. Am looking to buy my daughter-in-law one for Christmas as she likes it as much a I do.
I think the better you can do is to give your camera to her as a gift. In this way, you can buy then a better camera :)
Thanks for the thorough review. This is my favorite site for camera reviews. Can I ask if the nikon1 is SO much better than this camera? Price is not comparable. Thanks!
Okay George what don't you like about the Nikon
S9100? What camera would you recommend?
Canon EOS 450 D for about same money (400 EUR).
Excellent picture versus Nikon S9100.
Marylin here are my con' and pro' oppinions about S9100:
- I don't like Nikon S9100 because the pictures are not so clear in the middle zone. Even if I tried, I could not do anything from the camera settings. The focus is not in the center !
With the zoom, the pictures are ok, but without it .. they are blured.
- Pictures in low light are horible, even its specific Night function activated.
- The colours are not so natural
- The HD movies are ok.
- It is very fast in taking shots (faster than any camera in its range.
- Easy to use
My oppinion .. buy a canon 450 D at least. You will be very happy indeed ! (Is bigger, better and more proffesional)
Merry Christmaaasss !
Mine freezes up too.. And cant reboot even after reinserting the battery.. Lost the the warranty card.. Im screwed..
I am really lucky that I got the only good Nikon
S9100 out there. I get clear pictures and great
Close ups. Enough said and I'm off the bandwagon. Still
Love mine.
Great review, the camera arrived the day before Christmas and we excitedly started snapping. Major problem with indoor shots; the flash washes out photos fairly often. Horribly overexposed. I have never had this problem with a camera on Auto mode. When we turned off the flash, some photos were OK, others were blurry due to insufficient light. Are we doing something wrong?
Oh damn, I wish I read these comments first.
After days of reading reviews and looking at sample photos, particularly higher ISO quality, I ended up getting the S9100. With only a few test photos, at least image quality far out performs my previous TZ series cameras (sure they have features, but image quality is not 1 of them).
Anyway, was highly debating between the SX230, HX9V or S9100/S8200. Ended up with the S9100, but now wishing I got the HX9V instead as I don't fancy it my camera freezing (the TZ ruining my holidays before). Must check to see if there's any new firmware from Nikon.
I do own a DSLR, so this purchase was just to save lugging 3KG around all the time. Must admit been a Nikon man for many a years, and always been anti Sony, though next DSLR looks like it'll be a Sony. I do a lot of low light action shots, and Sony seem to have their processor tweaked nicely for this.
Purchased 1/14/12 as a back up to my new PEN E-P3. My wife wanted a "pocketable" camera for her casual use. Great little unit—good image quality and clarity as long as you do not attempt handheld 18x zoom photos—naturally they will be blurred with such a lightweight camera and exaggerated focal length! This model is probably being replaced soon since my favorite photo shop was selling the kit (camera, leather case & extended warranty) for $199—a savings of $180. Great deal on a fine camera!
I was talked into buying the Nikon S9100 whilst in Hong Kong in early November, 2011 and I was pleased with the few travel photos I took before coming home. Since I have been home I have mainly been using the camera to take photos of the grandchildren and to say I am disappointed is an understatement. I am lucky if one photo out of 20 don't turn out blurry. Am I doing something wrong or is it a fault with the camera. I have read that a lot of people have the same problem.
Wish I had never puchased the 9100 . After 2 months of light usage, it started freezing up on me. Merchant won't do anything, now to Nikon. I want a full refund - what a disaster. Picture were consistently blurry. I have been shooting for years. Total disappointment!
Thanks for your reply Kathy. I have just come back from two weeks away and I took my DSLR as well as the Nikon S9100. I am quite pleased with the clarity and colour of some of the photos, but the blurring issue is still there with movement. If it was a camera that cost under $100 I would just think "fine", but for the high price, I expect better. This is one photo that I took and you can see how vibrant the colour is, but nothing was moving at the time.
Which one do you suggest me between:
Nikon Coolpix S9100 or Canon Powershot SX240 ?!??
Thank you!
I loved the Nikon S9100 when I first bought it, but about 6 months out, the auto focus went crazy, and I had times where I could not turn it on, and times when I could not turn it off, and times when the focus feature just didn't work. Costco (where I first bought the camera) helped me walk through "fixes" and put me in touch with Nikon where they had me do things to "fix" the camera, which I thought fixed the issue, but after another 6 weeks of experimenting with pictures, the auto-focus really went crazy again. I have to send it in to Nikon to get them to repair the camera. I hope they stand by their product and fix it for me. BTW there is an external battery charger for those who think you have to charge the battery in the camera. Just have to do a little bit of searching on the internet to find it.
RE: Kathy Snider's post above. When I first bought my Nikon S9100 I was very pleased with how well it worked. About 6 months later though, the focus didn't work right. I thought it was me, but after ruining 93% of my Christmas pictures and then having the camera really bomb out on me on a trip, I concluded it was the camera, not me. Even if something isn't moving, I get blurry pictures, so I go back to using my cheaper Kodak V1073 Point and Shoot. Costco won't take the camera back, though their concierge service did try to help, thinking it was operator error, I'm sure; was put in touch with Nikon on the same call, and am sending the camera back to them tomorrow to be "fixed". I am as equally disappointed now with the NIKON as I was excited when I first got it. But a $300+ camera should last a lot longer than 6 months; I still have an old Olympus digital camera that works, it's just a little too heavy to take traveling and doesn't have the zoom capacity the Nikon does (18X). Let's hope Nikon can fix the issue, and make me a satisfied customer.
Hi Kathy,
I bought mine in Singapore on the way home from a three month trip to Scandinavia and the UK, so I am not sure if the Nikon warranty would be honoured. It is the second time I have had issues with things bought overseas, so never again. You don't save much by doing so I have found anyway. I think I will just have to put it down to experience and realise that no P&S camera will ever take photos as nice as a DSLR and take my DSLR everywhere. Make sure you let me know how you get on.
Nikon s9100 now freezes when I zoom…too many months to return. Has anyone found a solution or has Nikon solved?
@ Jem…. I solved the problem by reporting the same issues with my camera to NIKON and not giving up… it was finally resolved when they refunded my pruchase price. I was so disappointed because when the 9100 worked , the pictures were wonderful….
To Ann C. Since Nikon is an international dealer, I think you should try contacting them to get them to fix your issues with freezing, etc. I had a one year warranty, still well within that time frame to have fixed, just remember the squeaky wheel gets the oil/attention. When I called customer support Nikon sent me a note & a link for the U.S. users (they do have :
Thank you very much for contacting Nikon Technical Support.
For Nikon Service information, please see:
Title: How do I get my Nikon product serviced?
URL: http://support.nikontech.com/cgi-bin/nikonusa.cfg/php/enduser/std_adp.php?p_faqid=336
There is no need to call in advance for any approval or authorization; simply send the product in for evaluation with no accessories, unless part of the issue, and a photocopy of the receipt. Once logged in, service will send you a confirmation.
Sorry for the problems you have had with your Nikon product; Nikon Service strives to evaluate and repair all items as quickly as possible.
Hope you find this information helpful.
I still think you need to contact them and let them know your issues with the camera. Go to this link to get the 800 number and notice about 1/2 way down the page the areas in the world you can reach using the 800 phone number listed: http://support.nikonusa.com/app/answers/detail/a_id/238 - Good luck, and let us know how it all turns out. Kathy PS, Thanks Jeannine
Warning to all, we are having issues with the camera freezing. I am searching for a solutions right now, but this shouldn't happen with a camera that is 4 months old and hasn't been dropped or anything.
The freeze has just happened to me too :( - battery removal was the only option.
and 4 months later as well. What does this firmware have auto inbuilt problem timelines or what. Where they meant to make it 4 years so you start looking for a new camera. Ok that's conspiracy theory, but had to LOL (or was that cry) at the 4 month mark as well.
Well Nikon, I was just about to upgrade my D300 do a D800 or even D4. Seems I'll be going Canon 5D MkIII now. Not happy.
Nikon fanboy (or was),
Mine freezes too. Read a comment in this site. Fiddle with the zoom rings.. Walla! It unfreezes. Hadnt happened since.
can any body advice me the best camera in same price as nikon s9100.
why when I download the pictures many of them need to be rotated?
Robert (04/18/11)
If you're going to critique others' grammar and spelling, please spell summery (sic) correctly…
Happy days
Does anyone know if this problem of freezing has been solved by nikon? since this problem has been reported since last year have they not found the problem and solved it for new released models? or am i just overly optimistic!
This looks like the ideal camera for my downgrade needs. I have tried and compared the pictures to the sony hx9 and tz20 in jessops and i prefer this for a few reasons mainly picture tone (sonys is flat) focus at zoom is better than tz20. The freeze problem is putting me of though.
*rozas comment is interesting
any info advice?
Hi, John, Nikon has had my camera since April 6 and they are still waiting on major parts to fix it; they give themselves 45 days for repairs, which seems a little long to me. I loved the camera when it worked, but having to wait so long for repairs is a bit much.
same here had mine about 6 months.. turns on, screen works but none of the buttons work!!
guess its time to send it back..
already bought a samsung 850 to replace it.
S9100 has been a total disaster for me. Sent twice for repair. The camera does not focus in close range. When using zoom in low light, the pictures are blurry. Normal pictures, taken at normal range is not cripsy enough. S8100 had better pictures. I strongly feel that Nikon should recall these cameras. The problem, I think, is the software used in auto focus mode.
Hi,All - I don't know what the problem was, but after keeping my S9100 for 7 weeks and parts being on hold that were needed to "Fix" the issue, I finally called the service center (2 days in a row) and insisted on speaking with a supervisor indicating my issue. The camera was not going to be available for my upcoming vacation and since part holds can last for literally months, I requested they resolve the problem that day. The supervisor checked and got approval to send me a new camera - imagine my surprise when I opened the box and saw a brand new 2012 model of the S9300 (w/GPS). So you have to keep after them. I just hope this new camera took care of all the issues Nikon was having with the S9100. BTW, the S9300 seems to be working great (so far), have only had it 1 week, but am using the heck out of it. Be the squeaky wheel, insist Nikon replace your S9100 - obviously they knew there were issues and Yes, I agree, should recall the S9100 and replace all of them if they want to keep their good name.
which one is more worthy to buy, used nikon s9100 or used canon sx200is if both at the same price?..
Personally, with all the issues I had with the Nikon S9100 i.e., freezing up and fuzzy pictures, and after reading all the comments in this blog, I would NOT buy a used Nikson S9100, ever. JMHO.
I took some good pictures with it, but now it freezes up and is unusable. It's about a year old and I'm told I have to send it in and pay for repair. Considering the original purchase price, I guess I will do that, but I am quite dissatisfied. My previous cameras (other brands) lasted 8-10 years without issue. This one has been well cared for and lightly used. I purchased it based upon a family member's recommendation of the 8100 model - should have stuck with that one.
To Kathy - Kathy, I took your advice and emailed Nikon here in Australia. They were very helpful but I was told that the warranty was no good, so no luck there. I was asked to send some photos to them with exif details and they would check them out. The reply came back that there did seem to be focusing problems and that I could send the camera in for checking but there would be a charge for this. I have decided that as the camera was expensive to start with, I don't really want to spend any more money on it. Canon or Panasonic for me in future -never waste my money on Nikon again.
Hi, Ann,
I'm sorry contacting Nikon did not work for you. I understand your decision not to have the camera fixed. Was the camera out of warranty by the time you contacted them? I think my warranty was for a fully year here in the U.S. I guess I was lucky getting them to replace my camera with the 2012 9300 model since they had my 9100 for 7 weeks without any sign the part needed to fix it would come in before my vacation. So far, so good with the 9300, though it is a little slower on the trigger when taking a picture, because it is taking time to focus the picture. (which is OK by me). Like you, I would not buy a Nikon again. I have been very pleased with an older Olympus and a slightly older Kodak I still use, but I purchased the Nikon due to the 18X zoom factor, and have been pleased with the pictures I was able to get at Yosemite National Park. That place is so big, it's difficult to zoom in on the waterfalls, but the Nikon 9100 did it fine when it was Brand Spanking New.
Hi Kathy,
Thank you for your reply. The camera was only around 4 months old, but I was told that because it was bought overseas, that the warranty could not be honoured here in Australia. To say that I am disappointed in the whole journey into Nikon is a complete understatement - never again
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In a statement issued last night, leadership of the Assembly Democratic Caucus announced that Assemblyman Steven Brooks is no longer a member.-
"At this time, the organization has determined it's in Mr. Brooks and the organization's best interest to part ways," the statement said.-"The caucus encourages him to work on his health issues without the rigor of caucus business."
Brooks was arrested on Jan. 19 on charges he threatened Assembly Speaker Marilyn Kirkpatrick.
He attended the opening of the session on Monday where it was announced that he would seek medical leave. Brooks then repudiated that announcement and said he would take his seat and serve his term.


text: A shorter dub piece. Motivational and sort of silly, whilst laid back and groovy. I guess you have to listen to it to get the point. Easily loopable in a DAW or a video editing program. Sine sub bass, punchy kicks, synced delay with changing times, catchy, simple synth theme and so on.


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Federal Court Upholds Wisconsin Governor's Public-Sector Unionism Reforms
Workers asked court to uphold reform measure protecting most Badger State public workers from forced unionism
Chicago, IL (January 18, 2013) – Today, the U.S. Court of Appeals for the Seventh Circuit upheld all of Governor Scott Walker's public-sector unionism reform measures, also known as "Act 10."
With free legal assistance from the National Right to Work Foundation and the Wisconsin Institute for Law & Liberty, three Wisconsin public employees moved to intervene in the lawsuit in favor of the law after lawyers from seven unions, led by the Wisconsin Education Association Council, challenged it in federal court. The three civil servants, Pleasant Prairie teacher Kristi Lacroix, Waukesha high school teacher Nathan Berish, and trust fund specialist at the Wisconsin Department of Employee Trust Funds Ricardo Cruz, were permitted to file amicus briefs in the district court.
Union lawyers sought to strike down the law's annual union recertification requirements, ban on the use of taxpayer funded-payroll systems to collect union dues, new limits on the scope of what union officials can demand in contract negotiations, and a provision that granted most of Wisconsin's public employees Right to Work protections.


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November 24th, 2009 | Tags: Beirut, Lebanese, Lebanon, Maxime Chaya, School, Speech, St Coeur, Students | Category: Academic Institutions | Leave a comment
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toufic omran i am from R.B.I.S: you are so fantastic
tweety: he did a great job wallah .
tina: you are a amazing personnal i like you you have a courage
Shoghig: you made me realize how infinite can dreams be...
Omar Al Dana from wellspring [grade 4 ]: I want to be like you , a risktakere ;i loooooooove you
DHARI AL SALEH: congragulationsfor your succes maximum max
ibrahim sakr: hi max remember me i am a wellspring i came to villa audie on thursday 3 december 3
email@example.com: just spent a good part of the night on your site, the little mountain climbing i have done and my attachment to nature help me appreciate how wonderful are your achievements
Mireilla AbouRjeily: We are so proud of you I wish to do the same like you
Georges Assaf: We are proud of you Maxime!! You lift our Lebanese Spirit Up!!!
nadia rifai: hello i thank u for coming to our school expo and again i congradulate u n
Samia: You are a role model!
elie zgheib: go tiger
nadia from wellspring: i am so happy because you came to our school i kept my comic strip in class so maybe miss chirine could give it to you congradulation for your sucess
Andree: Dear Maxim.. From a little country to a far away land..wish we all have your determination..you are a world wide symbol of lebanese pride.. GOD BLESS YOU..
Rami: You have an amazing spirit and courage, we are all proud of your achievements! total RESPECT!
Mark: Still feeling so proud of what you have done... Max... the hero of Lebanon!!! One of so few in the world to do whatyou have done...
Nadine: vs etes venu chez ns a l'ecole(IC Ain Aar) on a tous ete impressiones vs etes la fierte du Liban!! Ur our biggest hero thanks for everytime you did ur best to raise lebanon's name very hight!! we are proud of u!! Alf mabrouf
MASAYA: "Maxim respire ,liban existe." Je suis trop fi�re d'�tre libanaise comme toi MAXIM.
Imad A. Aoun: Max,comme t'appelle tes amis,j'ai suivi avec fierte tes apparences a la TV et ce soir avec Bikra Ilna sur OTV...tu es notre fierte nationale avec un esprit propre ,fier et determine .Courage dans tout ce que tu entreprends,et que Dieu soit toujours avec toi !!!
Rami A: Maxime you are a history !!! we are so proud of you when i will grow up i will make the climb of everst ur are my superman !!!
JC: It's a great pleasure to meet such a brave conquerer!!!
R1: Max, I watched the first season of Everest and admired your professionalism and compassion and have tremendous respect for you and for all other mountaineers (like me) because of the many challenges you endured. Congratulations to you and to your country!
joumana Accad: I am so proud of you! You are a Lebanese hero!
Ben (NY): Maxime you ROCK !!! Bravo !! Congrats!!
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My job at the Charleston School of Law often makes me feel like a matchmaker. As I work to connect students with opportunities for practical legal experience through our Pro Bono Program, I sometimes am reminded of the song "Matchmaker" from the Broadway musical "Fiddler on the Roof."
Since the Charleston School of Law opened its doors in August 2004, it has had a mission to instill in its students the value of public service. Our Pro Bono Program, through which students provide free legal services under the supervision of licensed attorneys, has been there every step of the way.
All Charleston School of Law students must perform at least 30 hours of free legal work in the public interest to graduate. Many of our students go well beyond the requirement.
Since our first academic year, our students have contributed more than 166,000 hours of free legal services through our Pro Bono Program. That's comparable to an individual doing about 80 years of full-time work. Looking at recent graduating classes, about three-fourths performed more than the 30-hour requirement and about one-third performed 100 hours or more.
Today, our students can fulfill their pro bono requirement through work at one or more of over 130 approved pro bono sites. This work must be law related, supervised by a licensed attorney, and performed on behalf of a governmental, non-profit, charitable, or educational organization or for a private attorney who has a pro bono or court appointed case. In addition to volunteering at our approved pro bono sites, students can work through our office to craft their own pro bono experience. What's inspiring about our focus on the public interest is how it opens students to areas of the law that they might not have been exposed to otherwise. In fact, student pro bono work can translate to public interest work as a practicing attorney. For example, Charleston School of Law graduates Jeff Yungman and Mary Matthews serve as attorneys at the Crisis Ministries Homeless Justice Project, while Mallary Scheer helps provide civil legal services to low-income Charleston County residents at Charleston Pro Bono Legal Services.
Charleston Pro Bono Legal Services, which started almost simultaneously with the Charleston School of Law, will honor our retired founder and Chair Emeritus Alex Sanders at the second annual Charleston Pro Bono Reception tonight. As past president of the College of Charleston, former chief judge of the South Carolina Court of Appeals, former member of both the South Carolina House of Representatives and Senate, and as an educator, Judge Sanders' career has been devoted to public service.
As Judge Sanders said at a recent graduation ceremony, our graduates are unique because "they have learned the practice of law as a profession, having as the chief aim providing a public service, not merely earning a living. They have embraced a desire not only for praise but for praiseworthiness, for fair dealings as well as good deeds, for honor as well as advantage."
The Charleston community is indeed fortunate to have benefitted — and to continue to benefit — from the tens of thousands of hours of free legal services provided by our pro bono partners and hundreds of students.
The relationship between Charleston Pro Bono Legal Services and the Charleston School of Law can be described by paraphrasing one of the famous lines from the movie "Casablanca." Our partnership has been a beautiful friendship.
Thanks to Charleston Pro Bono Legal Services and all of our pro bono sites for your friendship and for helping us serve as a matchmaker to benefit our students and the Charleston community and beyond.
Michelle Mensore Condon, an attorney, is the director of public service and pro bono at the Charleston School of Law.


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10 Great Songs by the Worst Bands of All Time (Part 2)
If last week's column taught me anything, it's that no one is reading this. So, without further ado, here is the sequel to last week's column. Enjoy it.
#10. Ace of Base -- "Cruel Summer"
With a band like Ace of Base, it's tempting to just list one of their shit-pop radio staples like "The Sign" or "All That She Wants" as their best song ever and call it good. But here's the problem -- if those are the only songs anyone knows and Ace of Base is routinely spotted on lists of awful bands, doesn't that by default make the songs that got them there also kind of awful?
It sure does. To call sifting through the rubble that is the back catalog of Ace of Base "grueling" would be a massive understatement (except to people with real jobs). I did it, though, and here's what I came up with:
Granted, that's still a horrible song, but at least it's a cover of a relatively decent song:
Again, this is a really shitty version of that relatively decent song, but still, at least it's built upon a foundation of good.
#9. Justin Bieber -- "Somebody to Love"
Nicky Loh/Getty Images Entertainment/Getty Images
Me and the Biebs go way back on Cracked, starting in 2010, when I wrote this fantastic article about living five days undercover as a Justin Bieber fan. Since then, I've written about him for various reasons, my favorite being that he and his ex-girlfriend look exactly alike.
How do you decide which one to jerk off to first?
So I'm plenty familiar with his horrible music, and to me, one song in particular stands out as the undisputed best. This one:
You know how Prince gave away "Nothing Compares 2 U" and then got all bitter when someone else made it a massive hit instead of him? I think that might be the case with this song as well. It was originally recorded for Usher's sixth album, but when that project got delayed, the song ended up on Team Bieber.
Usher must have realized the mistake pretty quickly because, as released on Justin Bieber's album, "Somebody to Love" only features Usher on background vocals. By the time the video came out (which you can see above), Usher had promoted himself from background vocalist to featured guest. A shrewd move, considering the video is currently sitting at over 260 million views.
He wasn't done reclaiming his song, though. On Usher's seventh album, you'll find a re-recorded version, this time with him in the starring role and Justin Bieber as the featured guest:
In short, Usher did not let "Somebody to Love" go quietly. All of that evidence leads me to believe that, without a doubt, this is Justin Bieber's best song. I really don't know any other way to determine it. They all sound terrible to me.
#8. One Direction -- "Best Song Ever"
Cindy Ord/Getty Images Entertainment/Getty Images
I'm a big fan of audacity, both as a trait and as a free audio mixing program.
It's the only one I can afford.
It's the former (that means the first!) of those two that I want to talk about here, though, because there's a whole lot of it present in this video:
Is the music any good? Of course not! But you have to admire the moxie of a young band that not only feels important enough to make people wait through a four-minute Les Grossman skit just to get to their terrible song ...
The way to a tween's heart is through a Tropic Thunder reference.
... but also has the balls to call that terrible song "Best Song Ever." I may not enjoy the music, but damn if you shouldn't appreciate their misplaced confidence. It will serve them well when they're working the sales floor at an upscale retail outlet someday.
#7. Britney Spears -- "Toxic"
Frank Micelotta/Getty Images Entertainment/Getty Images
Well, this one is easy. While I'll admit that she's lacking a few qualities that normally make a performer great, like discernible musical ability, for example, I still don't entirely hate the songs of Britney Spears. In fact, I mentioned my choice here ("Toxic") in another recent column, where I state that I do indeed think this is a good song.
Here's hoping every choice is this easy going forward!
#6. Insane Clown Posse -- "Leck Mich Im Arsch"
Carlo Allegri/Getty Images Entertainment/Getty Images
Looks like they won't be! If I'm being completely honest, before I started writing this I'd listened to maybe two ICP songs in my entire life, and I couldn't tell you the name of either of them (I think one was an educational thing about how magnets work). As luck would have it, I didn't really need to, because while researching their catalog of timeless hits, I remembered that this happened once:
That's Insane Clown Posse covering Mozart with Jack White.
I don't care if it's an awful song (it is), just being able to type the sentence before this one made listening to it worth all the torment.


text: Just before 24th Street slopes onto Third Avenue with its rumbling noise of the Gowanus Expressway is a something unexpected for this part of South Brooklyn: a white walls, contemporary art gallery. 210 Gallery is quietly nestled between the green spires Our Lady of Czenstochowa church and the Gowanus inlet industry that rises its smoke stacks before an almost clear view of the Statue of Liberty. Despite the gallery being just around the corner from my apartment, I'd never stepped inside, always being drawn away by the comforting siren song of my coffee machine and potential rest after finally making it home after working all day in Manhattan. But I'd glimpsed its small, yet intriguing, shows through the large windows, and finally paid the gallery a visit last Sunday.Continue Reading →


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NASCAR driver Tony Stewart is recovering in a Des Moines hospital following a crash at Southern Iowa Speedway on Monday night.
Images: Tony Stewart injured in sprint car crash
Published On: Aug 06 2013 04:22:47 PM CDT Updated On: Aug 06 2013 04:25:47 PM CDT
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Quadruple Helices Appear To Have Role...
Developers of DTC Genetic Testing Are...
LC-MS Gains Favor Due To the...
Wall Street Decline Takes Its Toll...
Conformational change of a biomolecule—a change in its structure—is the ultimate basis for signaling in biology. A convenient and direct way of detecting structural changes in protein targets, and one that is scalable and requires small amounts of sample, would be a big help in definitively identifying compounds that act as agonists or antagonists, and especially useful for discovering allosteric ones. Conventional techniques such as NMR and x-ray crystallography provide atomic-level resolution but are not particularly suitable for drug discovery because of their intensive labor, sample, and time requirements.
This article reviews second-harmonic generation (SHG), a new screening platform for detecting conformational change, that is fast, scalable, and requires tiny amounts of sample. It can be used in either a label or label-free format. It is also suitable for fragment screening up to millimolar concentrations. It provides a direct answer to the question of whether a hit is an antagonist or an agonist, which is often difficult and time-intensive to ascertain with cell-based assays, particularly with fragment screens. In this methodology, protein samples must be purified, and in the case of membrane proteins reconstituted in one of several ways. Because only a picomole of target is needed per well, however, a little protein goes a long way.
As a detection modality, SHG works in a different way than fluorescence. It is a surface-sensitive technique because it only detects molecules right at an interface. Conformational change is detected when biomolecules are immobilized to the surface. Rather than absorbing and re-emitting light as in fluorescence, light is reflected in a nonlinear way off of a surface. The interface (surface plus biomolecules) converts a small amount of red pulsed laser light into second harmonic light at half the wavelength of the incident light.
For example, 800 nm light is converted to 400 nm, a wide spectral difference. Therefore, the shift is in the opposite direction than what is observed in fluorescence. In practice, this makes separating the signal from the incident light easy to do.
For many years, SHG has been used in the physical sciences to detect molecules and their orientation on surfaces (Figure 1). Only some molecules are SH-active, just as only some are fluorescent. As protein molecules are not generally SH-active, Biodesy has developed both label and label-free formats for detecting targets and their conformational changes on a surface.
For example, in label format purified, labeled protein is immobilized to a surface. A single type of label is used and it does not need to be applied site specifically. Incident light from a laser is directed to the surface. The surface and labels convert a small fraction of the incident light to second harmonic light, the baseline signal.
When the protein changes its structure upon binding ligand or drugs, this changes the amount of second harmonic light produced. In effect, the technique provides an instantaneous and direct readout of conformational change and is thus a molecular-level, functional screen. It is complementary to cell-based assays and can be used in hit generation or the hit-to-lead phase. Only a picomole of protein is needed per assay well. The signal-to-noise ratios are at least 20:1 for a four-second average with z'-factors of about 0.8. The response is in real time. With replicates, one can also measure IC50.
Joshua Salafsky, Ph.D. ([email protected]
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Bigg Boss 6: Vishal Karwal to enter the house
4 years ago
Vishal Karwal has given his nod to be a part of the show and will very soon be seen making an entry into the house Vishal Karwal, who has been a part of youth-oriented shows like MTV Roadies and Splitsvilla has been roped in by the makers of Bigg Boss 6 to be a part […]
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With the Fourth of July fast approaching, it�s time to start planning�and making�your holiday decor. Here, we round up ten DIY projects that are easy to make and will effortlessly bring a patriotic sensibility�to your dining room or outdoor patio celebration. Popsicle Tea Towels [caption id="attachment_330680" align="alignnone" width="480"] This article originally appeared as on Relish
Location, ST | website.com


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Thursday, May 8, 2014
I love my husband, and he loves me. But there are things about him - and men in general - that leave me stumped.
Take guns. Widdle wont let me have one.
I didnt grow up around guns - even with two brothers, a dad and a rural upbringing, we had none in the house. My father, a gentle man, would have gnawed off his foot before shooting anything. My brother, T-Bob, loved his Daisy BB gun until he shot a bird and it took a while to die. He threw up and aimed only at paper targets after that.
But times have changed. Today I live in the country, with A) No immediate neighbors, B) Two deaf dogs and C) A husband who travels. I have begged Widdle for a gun and he refuses.
You get kind of loopy when you take your sleeping pills, he says. What if you shot me?
News flash: My sleeping pills make me sleepy. They do not transform me into a whacked-out weapon-wielding wife.
And heres the kicker: Last week, Widdle was invited to a skeet shoot and he emerged from the guest bedroom carrying TWO SHOTGUNS I DIDNT KNOW WE HAD.
This was a big honking deal. Will you show me how to fire one so I can keep it behind the bedroom door, like Joe Bidens wife? I asked, hopefully.
No, you get kind of loopy when
Never mind, I said, and that was that.
Another thing I dont understand: Widdle rarely eats my cooking. I dont cook that often, but no matter what I make, hes all, Oh, Im off vegetables/chicken /soup/rice/seafood lately. Ill just eat an apple. Since he and I have totally different diets, its not like I can eat what I cook for him. (I know, its complicated.)
So my spurned culinary love sits uneaten in the fridge until I throw it out the back door for the chickens and dogs to fight over. (And judging by their reaction, I make a mean sausage gumbo. So there.)
Its not just Widdle--I know a guy who loves caramel cake. When he and his wife go to a nice restaurant he always orders caramel cake for dessert. He tears recipes for caramel cake out of magazines, and bookmarks others online. So one day his wife cleared her schedule and made him a caramel cake, with six layers and boiled icing from scratch. She was proud of that cake. When hubby came home, she lifted the cover on the cake plate and waited for applause.
Eh, I need to lose a few pounds, he said. But thanks.
I probably would have shot him, which may explain why Widdle wont let me have a gun.
The last thing I dont understand - oh, who am I kidding? There are 43,219 other things I dont get about men - is how guys can sleep anywhere, anytime. I dont know any women who do this, only men. (I cant sleep even after a warm bath, medication and a boring book.)
If my dad got tired while driving, hed pull over and sleep for 10 minutes - under a glaring streetlight, with traffic rushing by. On a plane tossing in turbulent skies, Widdle takes a quick catnap. Watching a movie is an opportunity to snore so loud he wakes himself up. He will let the dog out, sit in the Queen Anne chair and pass out cold. Sitting upright.
Men. They wont give you a gun, eat your cake or stay awake during a Meryl Streep movie. Its a good thing they smell nice.
Julie R. Smith, who knows men are from Mars, can be reached at email@example.com.
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Lea Michele Was with Friends When She Learned Cory Monteith Died
"Lea started freaking out, she was distraught. No one knew what to say. It was horrible. She couldn't believe it," a source tells PEOPLE.
The call, the source adds, came from a friend who didn't want Michele, 26, to hear about Monteith's death at 31 from anyone else.
A friend of Michele's then suggested she leave home to avoid unwanted attention from paparazzi once news of Monteith's death became public.
"She needed to get out of her house, it was extremely emotional," says the source. "So she left and stayed in the home of her friend."
Since Monteith died on July 13 from a toxic mixture of heroin and alcohol, Michele has been grieving with his family and attended a private cremation ceremony last Tuesday in Vancouver.
"They are supporting each other as they endure this profound loss together," Michele's reps said in a statement, which also expressed Michele's gratitude for "all the love and support she's received from family, friends, and fans."
A different source told PEOPLE recently that the pair were discussing marriage and planned to walk down the aisle.
For much more on how Lea Michele is coping with the death of Cory Monteith, pick up the next issue of PEOPLE, on newsstands soon
Fans of Monteith may make donations in his name to three charities that were especially important to him: Project Limelight Society, which exposes youth living in Vancouver's Downtown Eastside to the arts; Virgin Unite, founded to support entrepreneurial efforts to better the world; and Chrysalis, which helps homeless and low-income individuals find employment.


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The Stetson women's basketball team learned Tuesday that it will open the 2013-14 season against NCAA Sweet 16 participant Oklahoma on Friday, Nov. 8 in Norman, Okla., in the first round of the Preseason WNIT Tournament. Tip-off is set for 8 p.m. Eastern Time.
While Stetson (24-9 in 2012-13) and Oklahoma (24-11) have never met on the hardwood, both teams got a good look at each other in the NCAA Tournament this past March. The Hatters and Sooners each participated in the Columbus Regional, where Oklahoma posted wins over Central Michigan and UCLA to advance to the Sweet 16. The Sooners finished the season ranked 23rd in the USA Today Top 25 Coaches Poll.
"It will be fun, we will see where we are right away," Stetson head coach Lynn Bria said. "(Oklahoma) will have a real good veteran team because I don't think they lost very much from last year. We scouted them and we saw them in person, and they will pretty much be the same team if not better. Arguably they could be the best team in the WNIT field."
The winner of the Stetson-Oklahoma game will advance to play the winner of the Wichita State-IPFW game on either Nov. 10 or 11. Teams that lose in the first two rounds will play consolation games on the second weekend, Nov. 15-16. All games are hosted by participating schools.
According to the WNIT, the consolation bracket will be re-drawn to form new matchups based on the geography of teams involved, who can/cannot host, recent history of teams, etc. The consolation bracket will be released Nov. 10 after all of the first round games are complete. The Preseason WNIT tournament features a three-game guarantee format.
Teams that remain in the winner's bracket will compete in the semifinals on Nov. 14. The championship game will be nationally televised LIVE in HD on CBS Sports Network at 4 pm ET on Sunday, Nov. 17.
Stetson's full schedule will be released at a later date.


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We've never "done" the Easter Bunny at our house. It's not a religious reason or anything, because Santa certainly makes a visit, we just never have put out Easter baskets or anything like that. (Most likely do to financial reasons in the beginning and over the years, we just didn't bring it up (which is surprising to me since as a child Easter was my favorite holiday due to the combination of Christ's resurrection, church festivities, dressy outfits, and Easter basket goodies-- one year I got a Cabbage Patch Doll! One of my best memories ever.))
So when Grayson heard me say something about the Easter Bunny as we passed a yard displaying a huge blow up Winnie the Pooh holding an egg next to an even larger blow-up bunny, he asked What's the Easter Buddy?
I realized he had never heard of the Easter Bunny before.
My explanation was weak but I was caught off-guard. "Easter BUNNY. Like a rabbit. It's this guy. He wears a bunny costume."
Oh, is it pink?
And he never brought it up again.
Semi-unrelated: Today Ivy saw a bunny in the grass as she sat on the window-sill and was tickled TICKLED I tell you. She clasped her little hands over her mouth and laughed deep down "da bud-dy! Bud-dy!"
How ever you celebrate it, happy happy Easter, my friends. It's still my favorite.


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More than 35,000 runners will take the streets of London on Sunday morning, many wearing black ribbons in honor of victims in last week's Boston Marathon bombings.
The race will begin with a moment of silence for the victims of the Boston blasts that killed three and injured more than 170 people. The London Marathon, which begins with the elite women's start at 4 a.m. ET, will be held six days after the explosions at the Boston finish line. The men's elite field and mass start will go off at 5 a.m. ET.
London Marathon organizers will donate 2 pounds for every finisher to The One Fund Boston, a charity that is raising money for victims and their families. Registration closed with 35,079 accepted applicants.
London's 26.2-mile course, which begins in the city's southeast Blackheath district and ends at Buckingham Palace, will be heavily guarded by police. Met Police will have 40% more officers on duty than last year, the BBC reported.
London is known as a flat, fast course. In 2003, Britain's Paula Radcliffe set a women's world record on the London course, winning in 2:15:25. In 2011, Emmanuel Mutai of Kenya set a course record of 2:04:40.
The elite men's field includes eleven runners — all from Kenya or Ethiopia — who have personal-bests of under 2 hours, 6 minutes. Wilson Kipsang of Kenya returns after winning in 2:04:44 last year, four seconds off the course record. All three London Olympic medalists from last year — Uganda's Stephen Kiprotich, Kenya's Abel Kirui and Kipsang — are running Sunday.
In the women's race, Olympic gold medalist Tiki Gelana of Ethiopia is the favorite. She won the Rotterdam Marathon in April 2012 in 2:18:58, making her one of just four women in history to have broken 2:19.


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NSCLC is "Major Battlefield" as Merck,...
Expanding Use of NGS Has Largely...
Wall Street Decline Takes Its Toll...
Developers of DTC Genetic Testing Are...
Outsourcing has become so paramount to a pharmaceutical firm's strategy that it is a given that noncore functions will be outsourced. Core functions, however, like the discovery of potential new drugs, used to remain in house. This pattern has been changing as companies are now routinely outsourcing a number of core functions including clinical trial management, manufacturing, and, increasingly, portions of drug discovery.
Declining R&D budgets are a factor. Overall expenditures on discovering and developing new drugs by PhRMA members increased nearly 10% in 2010 to reach $50.7 billion. The 2010 rise was short-lived as PhRMA estimates R&D spending dropped just over 2% to $49.5 billion in 2011.
Outsourcing has proven to be a useful tool for pharmaceutical companies to manage their core functions. It has also resulted in time and cost savings as well as financial and operational flexibility.
Drug discovery requires technical expertise in the areas of molecular biology, ultra-high throughput screening, molecular and behavioral pharmacology, and combinatorial, medicinal, and analytical chemistry. The process can be organized into four stages: target identification, target validation, high-speed screening, and lead optimization.
It is a high-cost, risky business because only a fraction of the therapeutic targets selected for study will actually yield products that obtain regulatory approval from the FDA. The average drug can take 10-plus years to progress from the discovery phase to the clinic, with only one compound out of 10,000 evolving into a viable product.
Discovery has become increasing complex since the 1990s as a result of advances in molecular biology and the emergence of new-generation biological therapies. These advances plus the emergence of new technologies have made it unsustainable for companies to undertake all drug discovery functions in-house. Therefore, the industry has chosen to outsource core drug discovery functions more frequently.
Crossover and new advancements in chemistry, molecular biology, pharmacology, microbiology, and biochemistry have resulted in the evolution of new methodologies and their application in drug discovery. These new technologies come with the promise of generating greater numbers of more effective drugs, while maintaining or reducing current costs.
Overall, Kalorama Information sees the market for outsourced drug discovery services as robust with an optimistic outlook going forward, despite the current unsettled economic environment. The global market reached $9.4 billion in 2011, which increased 15% from $8.2 billion in 2010.
This market is expected to experience robust growth reaching $11.1 billion in 2012. The global drug discovery outsourcing market is expected to grow at a compound annual rate of 16% over the next five years, exceeding $21 billion by 2016.
Another major trend that continues to gain momentum is choosing outsourcing partners in Asia and Eastern Europe. It is not only large pharmaceutical and biopharmaceutical companies that are moving their outsourcing offshore, but smaller biopharmaceutical companies are following this trend as well.
Small biopharmaceutical firms such as virtual companies that lack the infrastructure to carry out complex chemistry, biology, and lead-optimization services are choosing outsourcing partners in India or China, thus expanding the rapidly evolving global drug discovery outsourcing market.
The number of Chinese CROs offering drug discovery services has expanded significantly since 2004. Only a few companies, albeit fast-growing companies, were operating in Shanghai in 2004. However, in three years this changed very quickly. By late 2007, several drug discovery laboratories were opened in Shanghai, Beijing, Suzhou, Guangzhou, and other cities.
India's pharmaceutical industry is a robust enterprise driven by its emergence as a global leader in the generic manufacturing field, as well as its contract clinical research and contract manufacturing organizations. Drug discovery in India is still in its infancy, and it has only been recently that contract drug discovery research has become a focus.
Asia is not the only beneficiary of the growth in outsourcing. CROs in Russia and Ukraine emerged as the Soviet bloc dissolved in the early 1990s. After the breakup, scientific funding plunged, and many highly experienced and highly educated chemists essentially found themselves out of work.
As major pharmaceutical companies scale down their own R&D operations, offshoring critical tasks such as discovery will become more prevalent.
Bruce Carlson ([email protected]) is publisher at Kalorama Information.
Bruce Carlson ([email protected]) is publisher at Kalorama Information.
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Novum Pharma recently raised the price of an acne cream by over 3,900% in less than a year-and-a-half and Mylan increased price of EpiPen from $100 to $608 . Do you think pharmaceutical companies need to be subjected to price controls?
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text: Never heard of Kerrygold until today. Went to their website, and saw another thread on it, and will probably try it. It is made from the milk of grass-fed cows, and a lot of people in this community apparently use it. I use the same butter you do, but willing to give Kerrygold a try.


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With several stores getting a jump on Black Friday this evening, local police are ready for the onslaught of shoppers.
Stores such as Sears, Roebuck and Co. in the Logan Valley Mall and Toys R Us in the Park Hills Plaza will open their doors to bargain hunters at 8 p.m. while Target in Sierra North Plaza will open at 9 p.m.
Both Logan Township and Allegheny Township police said the influx of shoppers creates problems for them.
"Since the stores started opening earlier, we've had issues every year, significant issues. The lines start at noon on Thanksgiving Day, and people get agitated. We have had disorderly conduct with fighting and people cutting in line. We have had arrests," Logan Township Chief Ron Heller said. "We will have a full complement of officers on duty Thanksgiving Day and Friday. We will just deal with things as we have to."
"We will have extra patrols on duty to deal with any issues, accidents or problems in the stores," said Allegheny Township Chief P. Richard Books. "During the evening shift, we will boost up our patrols when the crowds start to gather."
Allegheny Township heads up security for Target.
"We have increased security both inside and outside of the building," said Randy Hickox, store team leader.
"We try to be highly visible to prevent things from happening," Books said. "We will have a presence inside the store; they contact us every year, and we work with them."
Books said shoppers need to use some common sense.
"Keep your car doors locked, keep your packages out of site or in the trunk and secure your purses the best you can," Books said. "Be nice and remember the holiday season."
Heller agrees: People need to remember it is the holiday season.
"I understand there will be bargains out there, but after that, there will still be bargains," Heller said. "Be calm, patient and respectful of the others and things should work out."


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Attention Toronto Fans, tickets for the Mirvish shows of American Idiot are now on sale! The tour will play the Royal Alexandra Theatre March 11 - 16 for one week only. Get your tickets now at http://www.mirvish.com/shows/americanidiot.
Idiot Nation members, log into www.gdidiotnation.com for your exclusive chance to win a pair of tickets and a post-show meet and greet with the cast!