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James Franklin's first junior day as Penn State football coach has paid huge dividends.
The Nittany Lions got the ball rolling in a big way to start their 2015 recruiting class with three verbal commitments on Saturday as, despite the recent snowstorm, Penn State hosted a number of underclassman prospects.
The newest Lions are Archbishop Wood offensive lineman Ryan Bates, Connecticut defensive back Jarvis Miller and Maryland defensive end Kamonte Carter.
Miller, a 6-foot-2, 188-pounder from Windsor Locks High School who could play either safety or cornerback, was the first to commit, according to the Lions247 website. He rushed for 1,611 yards and made 81 tackles this season.
"It was the perfect place for me. It was a family atmosphere, and I really love the coaching staff," Miller said while on his way home about his reason for committing. "I love what Penn state and coaching staff stand for and that is family and total commitment to win championships."
Bates and Carter both are consensus four-star prospects who were considered among the most likely players to become members of this recruiting class early in the process.
Carter is a 6-4, 235-pound defensive end from Gaithersburg, Md. A good enough athlete to play some quarterback and punt for his high school team, too, while sometimes sprinting and running hurdles in track in addition to throwing the discus and shot, Carter already had offers from Michigan State, Nebraska, Maryland, Pitt, Kentucky and North Carolina State.
Bates, meanwhile, is rated as the consensus No. 3 prospect in the state. He had South Carolina along with Penn State at the top of his list entering the weekend but also had a slew of scholarship offers from colleges like Ohio State, Auburn, Miami, Michigan, Michigan State, Pitt and Virginia. The 6-5, 285-pounder is considered a tackle prospect who could eventually move to guard.
"The reason I chose Penn State is that there isn't a better university in the country that has top of the notch academics while having an excellent football program," Bates said. "As soon as I walked in the campus in the beginning of last summer for a camp I knew this is the place for me. There isn't a better fan base or alumni group in the country like PSU's. For awhile now, I knew this is the place for me and this is the place I want to play my college football."
Bates also is the high school teammate of Jake Cooper, who recently received an offer and was thought by many to be the best bet to become Penn State's first 2015 recruit. Cooper might not be far behind - he's expected to be in University Park early this week.
"It's a possibility," Cooper, who also has Northwestern, Duke, Syracuse, Rutgers, Georgia Tech and Boston College on his list, said when asked if he might commit. "I'm very high on Penn State."
Cooper said he wasn't surprised Bates committed; they've been talking about who would pledge to the Lions first.
"I was thrilled for him," Cooper said. "He was so pumped when he told me."
According to published reports, the Lions hosted a strong group of underclassmen, which also included Baldwin offensive tackle Sterling Jenkins, Maryland defensive tackle Adam McLean, New Jersey quarterback Brandon Wimbush, Central Valley cornerback Jordan Whitehead, St. Joseph's Prep corner John Reid, Ohio linebacker Jerome Baker, Great Valley defensive end Ryan Buchholz, Council Rock North quarterback Brandon McIlwain, Frankford defensive end Shareef Miller, New Jersey athlete Myles Hartsfield, New Jersey linebacker Jordan Fox and Woodland Hills running back Miles Sanders.
Buchholz and Miller are considered possible early commitments, while players like Jenkins, McLean, Wimbush, Baker, Whitehead and Reid could be marquee recruits for this class.
"Penn State always shows so much love on campus and social media," Jenkins said via Twitter.


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Prince William Attends The Hobbit Premiere Without Kate
The dashing young royal told guests at the special screening of the tale from Middle Earth that Kate would have "loved" to have attended the event. But the expectant mom has had to cancel a number of appearances while she battles severe morning sickness caused by hyperemesis gravidarum.
Tuxedoed William, 30, was the guest of honor at the royal premiere at the Odeon in London's Leicester Square, where he met filmmakers and some of the movie's stars, including Sir Ian McKellen and Cate Blanchett.
The cinema's general manager Tessa Street met William in the welcome line and asked about Kate. "I passed on my best wishes to Kate and he said, 'She would have loved to have been here if she could,' " Street told reporters.
The evening raised money for the Cinema and Television Benevolent Fund, and one of the fund's trustees Debbie Chalet also met the prince. "I said to William 'Thank you for taking the time to come and be here tonight,' because I'm sure he wants to be at home making sure Kate's okay."
Blanchett, who stars as Galadriel in The Hobbit, braved the chilly temperatures in a backless white Givenchy gown. Asked on the carpet how she was doing, she said, "I'm cold, but very excited."
Inside, just before the movie started, McKellen, who plays Gandalf in the movie, led the audience in sending best wishes to Kate.

subset: commoncrawl


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Serves 4 |
Prep Time 15 minutes |
Cook Time 10 minutes
6 cups kale, (about 1 large bunch)
1 quart boiling water, for blanching kale
1 Tbsp Eden Extra Virgin Olive Oil
2 cloves garlic, minced
1 small red onion, sliced into thin rings
2 tsp Eden Shoyu Soy Sauce
1 1/2 tsp lemon juice, freshly squeezed
Tear the leaves off the kale into bite-size pieces. Slice the stems into 1 inch long pieces. Blanch the stems for 2 to 3 minutes. Remove, place in a strainer, quickly rinse under cold water to halt cooking. Blanch the kale leaves for 1 to 2 minutes, and rinse in a strainer under cold water. Drain.
Heat the oil in a medium skillet and sauté the garlic for 1 minute. Saute the onions for 2 to 3 minutes. Add the kale leaves, stems and shoyu soy sauce. Sauté for 2 to 3 minutes, stirring constantly. Sprinkle the lemon juice over and toss to mix. Serve immediately after adding the lemon juice or the leaves may loose their bright green color.
American, Japanese Food, Macrobiotic, No Sweetener Added, Oils, Side Dish, Vegan


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Quality Education in the Benedictine Tradition
May 14, 2012
Students in the Modern China honors course taught by Dr. Tina Phillips Johnson, assistant professor of history in the Saint Vincent College School of Humanities and Fine Arts, celebrated the opening of a newly decorated computer laboratory in Gerard Hall on May 8. The lab features the style of a Chinese teahouse and includes authentic and historical replicas of Chinese culture, miniature Chinese musical instruments, lanterns, bamboo, a Chinese dragon, works of popular literature and Confucian and Buddhist influences. A chart of Saint Vincent College's own history with China is part of the décor. Students who participated in the project include, standing from left, Casey Wagner, a sophomore environmental science major from Greensburg; Bethany Biesinger, a senior English major from Johnstown; Dakota Hutchinson, a junior biology major from Rector; Joshua Catalano, a senior history major from Saint Marys; Anna Steighner, a senior political science major from Kittanning; Megan Cunningham, a senior history major from West Newton; Claire Shrontz, a junior English major from Claysville; Jaime Bowker, a senior history major from Pittsburgh (15236); Stephanie Kiesel, a senior history major from Irwin; and Dr. Johnson; kneeling, from left, are Rebecca McGrail, a junior environmental chemistry major from Steubenville, Ohio; and Michelle Koenig, a sophomore history major from Avella. Missing from photo is Sean Malone, a junior history major from Allison Park. View photos of the tearoom on Flickr: http://www.flickr.com/photos/saintvincentcollege/sets/72157629654746002/
Follow us on Twitter: @SVCPublicity Like us on Facebook: Saint Vincent College Public Relations


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Rhonda Lovelace was named director of the Integrated Campus Center (ICC) in March 2007. She began her career at Philander Smith College in October 1997 as a program coordinatorfor the TRIO-Upward Bound Program.
Ms. Lovelace is responsible for the day-to-day operations of the college's Integrated
Campus Center, a one-stop shop within the Division of Student Affairs that offers
an array of services such as Freshman Advising; Academic Support Services; ADA Disability
Support Services; Career Services; and Psychotherapeutic Services. She is also the
chair of New Student Orientation.
Ms. Lovelace earned her bachelor of arts degree in business administration from Philander Smith College in 1989 and holds a master's degree in management and human resources development from Webster University. She is a graduate of Leadership Greater Little Rock Class XXV.


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V/T's long program is J.S. Bach's Chaconne from Partita 2 in D.
V/T's long program is J.S. Bach's Chaconne from Partita 2 in D.
To be exact,Volosozhar & Trankov's LP is Ikuko Kawai's "Violin Muse" (also known as "Violin Muse Based On Two Chaconne"), in honor of Japanese tsunami/quake victims; one of the two Chaconne's is J.S. Bach's Chaconne from Partita 2 in D, and the other of which is Vitali's Chaconne.
But what I would like to know, is what is V/T's SP music?
Shari & Christian placed second at JGP Bosphorus. They have not updated their ISU bio for music. The identification I have for their programs is this:
Can anyone reading add more detail?
Shari Koch & Christian Nüchtern GER
SD Feeling Good; Hey Pachuco
Version at Austria
FD Vocal version of Albinino's Adagio (is the singer Lara Fabian)?
Version at Austria
Version at Istanbul
Last edited by dorispulaski; 09-23-2012 at 10:25 AM.
As I posted before - The Godfather. I don't know the performer, though.But what I would like to know, is what is V/T's SP music?
Thank y6ou-when I checked my listing I didn't find it there.
The following JGP ice dancers have updated ISU bios
Sara Cibulkova & Alvaras Stravinskas LTU
SD Blues; Swing
FD Never Do a Tango with an Eskimo by Alma Cogan; You Don't Have to Say You Love Me by Dusty Springfield
Szilia Magyar & Daniel Illes HUN
SD Blues: I Wanna Walk You Home by Fats Domingo; Quickstep: Zoot Suit Riot
FD The Phantom of the Opera by Andrew Lloyd Webber
Anna Nagornyuk & Viktor Kovalenko UZB
SD Blues: One Night by Elvis Presley; Jive: Long Tall Sally by Elvis Presley
FD Me Voy by Jasmin Levy; Flamenco
Millie Paterson & Edward Carstairs GBR
SD Blues: Mad World by Alex Parks; Swing; PJ and Rooster by Outkast
FD Ben from "Cirque du Soleil"; They Don't Care About Us from "Cirque du Soleil"
Christine Smith & Simon Eisenbauer AUT
SD Blues: Scary Films by Katie Melua; Quickstep: Things by Robbie Williams
FD Suspicious Minds by Elvis Presley; Way Down by Elvis Presley
Karina Uzurova & Ilias Ali KAZ
SD Blues: Only You ; Swing
FD Live for the One I have (from Notre Dame de Paris) by Richard Cocciante; The Age of the Cathedrals (from Notre Dame de Paris) by Richard Cocciante; The Refugees (from Notre Dame de Paris) by Richard Cocciante
Two more junior men with updated ISU bios:
Abish Baytkanov KAZ
SP From Paris With Love
LP Windtalkers (soundtrack) by James Horner
Shoma Uno JPN
SP Tanguera
LP Steps
And a lot of junior ladies:
Melisa Sema Atik TUR
SP Winter from Four Seasons by A. Vivaldi
LP The Mask of Zorro (soundtrack) by James Horner
Evgenia Gerasimova RUS
SP The Barber of Seville by G. Rossini
LP Symphony No. 5 by Ludwig van Beethoven
Xiaowen Guo CHN
SP Howl's Moving Castle (soundtrack)
LP Grenada
Yong Yen Tiffany Lau HKG
SP Samba & Seniorita, both performed by Bond
LP My Drag by Squirrel Nut Zippers; Bound to You; Hip Hip Chin Chin performed by Club des Belugas
Victoria Manni ITA
SP Por una cabeza (from "Secnt of a Woman") soundtrack
LP Carmen Suite by Georges Bizet
Jennifer Parker GER
SP Concert Fantasy on Mozart's Magic Flute, Op. 54 by Pablo de Sarasate
LP La Sylphide by Herman Severin Lovenskiold
Sandra Ristivojevic SRB
SP Tango Carmen
LP Michael Meets Mozart by the Piano Guys
Miu Sato JPN
SP Silent Jealousy
LP Cinderella
Sabrina Schulz AUT
SP Far Away by Apocalyptica Music
LP Feeling Good peformed by Escala
Anna Shersak RUS
LP Don Quixote by Minkus (last year's)
Ivett Toth HUN
SP Mohabbatein (soundtrack) by Jatin Latit
LP Barcelona by John Tesh
Zselyke Kenez Rou
SP Compilation of Music
LP Cabaret (soundtrack)
Mary Fay Vangeystelen ROU
SP Khorobushko performed by Bond Music
LP Giselle by Adolphe Adam
Jialei Wang CHN
SP Love Story
LP Gone With the Wind (soundtrack)
Natascha Zangl AUT
SP Waltz Music
LP Professor Leyton
Last edited by dorispulaski; 09-26-2012 at 06:45 AM.
do we know what Kostner and Mao are skating to yet?
Cross-posting from Nebelhorn competition thread:
FYI from "Absolute Skating":
"Nebelhorn Flash" Short program we saw today from Caydee and John is only three weeks old, they even didn't have time to update their profile which still has the "old" music. The program was created after the advice they got at Champs Camp. It was choreographed by their coach Dalilah Sappenfield.http://www.facebook.com/permalink.ph...13697665347647
But I haven't seen any description of what their new program is.
I'm fairly sure, from watching it, that Alexander Samarin's (RUS) program (from JGP Sencila Bled) is to the Mahogany soundtrack suite by Michael Masser (Diana Ross did a vocal version of it called Do You Know Where You're Going To?)
Mahogany was a movie in 1975.
And Anna Yanovskaya & Sergey Mozgov RUS short dance is Bensonhurst Blues & Wilson Pickett's Land of 1000 Dances
The sound system in Bled is much clearer than at the previous JGP's this season.
Last edited by dorispulaski; 09-28-2012 at 02:13 PM.
Word from Nebelhorn is that Shelepen changed her SP music to Perhaps, Perhaps, Perhaps from Autumn Leaves.
Nmsis & Marshan at FSU have identified Yanovskaya & Mozgov's FD music.
It's Muktab:El Clon from the theme of a Brazilian TV show,
plus Ya Habibi Yalla from Ishtar & The Gypsy Kings


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The actress, who is credited as being a rock for her Glee costar as he battles addiction, is getting some support of her own – from her parents, who have been visiting her in Los Angeles this week.
Michele, 26, was seen grinning as the family arrived at the Sugarfish sushi restaurant on Thursday – her first photo out since Monteith's news broke.
"Ended the day with a perfect dinner with mom and dad:) Now catching up on tonight's episode of #Glee!" she wrote on Twitter afterward.
Michele also posted a photo of herself stretching as she went for a hike in the Hollywood Hills. "Living the fit life!" she wrote.
Monteith, 30, entered rehab two weeks ago for substance addiction. Michele told PEOPLE exclusively at the time: "I love and support Cory and will stand by him through this. I am grateful and proud he made this decision."
Courtesy Lea Michele


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Sunday, May 5, 2013
Ms. Llewellyn Reed, age 90, died at home, March 16, 2013.
A memorial service will be held at St. Paul's Church on Saturday morning, May 11, 2013 at 11 o'clock officiated by Rev. John Scott. There will be a reception immediately following the service in the Atrium at the church. The rite of committal will take place at St. George Cemetery at 3 o'clock. Memorials may be sent in lieu of flowers to St. Paul's Church, 111 Waring Street, Summerville, SC 29483 or Amedysis Hospice Care, 1027 Physicians Drive, Suite 240, Charleston, SC 29414 or charity of your choice.
Arrangements by Parks Funeral Home, 130 West 1st North Street, Summerville, SC 29483.
© 2016 The Journal Scene an Evening Post Industries company. All Rights Reserved.
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text:
Showing 1-24 of 3,205 items
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This Lincoln Park boutique features handmade purses, totes, and accessories. Design your own bag, including style and materials, and have your one-of-a-kind creation shipped to you within four weeks.
1401 West Restaurant at Chicago Marriott Oak Brook
Featuring prime steaks and seafood, our chef blends innovative American cuisine with French country cooking to create regional and seasonal specialties with full bodied flavors.
CITY:Oak Brook
1492 Tapas Bar is a state-of-the-art Spanish traditional and new age cuisine restaurant in Chicago. Featuring an outstanding menu and wine list.
Winner of the Broadway in Chicago 2013 Emerging Theater Award and named Chicago Magazine's Best Emerging Theater of 2013, 16th Street Theater presents award-winning new plays at affordable prices. A nationally-recognized professional Equity theater, 16th Street is a program of the North Berwyn Park District and operates year round out of the Berwyn Cultural Center just 9 miles west of downtown Chicago. Come engage with us!
1913 Restaurant + Wine Bar is located in downtown Roselle, Illinois and features authentic Country European fare inspired by Italian and French cuisine. The menu features myriad small plates and pizzettes along with pastas and pizzas, all centered upon the freshest ingredients. Our extensive wine + beer list is unlike anything found in the area, featuring over 25 craft beers and 80 French + Italian wines by the bottle and glass.
2015 Elgin Short Film Festival
The 7th Annual Elgin Short Film Festival promises to be an entertaining evening of some of the very best in short films by some of the very best up-and-coming filmmakers.You are invited to the award ceremony and screening of finalists taking place in Elgin, IL on Saturday, September 26, 2015.
2nd Annual Outdoor Sculpture Walk
Take a self-guided tour of public art from June 2 to September 2 as part of the 2nd annual Sculpture Walk in downtown Oak Park. The walk features 12 world-class sculptures prominently placed among Oak Park's many shops and restaurants.
CITY:Oak Park
31st Annual St. Charles Scarecrow Festival
More than 100 handcrafted Scarecrows on display. View and vote for your favorites. Huge juried craft show, carnival, great food, continuous free live entertainment, many free children's activities, make your own scarecrow, and much more! A celebration of the autumn season!
CITY:St. Charles
Nano brewery specializing in small, hand-crafted batches of classic beer styles with a twist. Every beer is brewed on-site. Limited food menu. Drink local. Beer is good.
CITY:Tinley Park
360 Chicago's (formerly John Hancock Observatory) epic new attraction that will forever change the way visitors see Chicago. TILT debuts in the spring of 2014, providing the ultimate window to the Windy City. A one-of-a-kind experience, TILT is an enclosed, glass and steel moveable platform that holds up to eight visitors per cycle. Once safely situated inside, the platform slowly tilts outward to an adventurous angle, generating downward-facing views of Chicago – from one thousand feet above The Magnificent Mile®. TILT gives thrill-seekers an exciting and safe way to take in unsurpassable views of the city, from a never-before-seen angle. Check website for opening dates and hours.
360 Chicago's (formerly John Hancock Observatory) epic new attraction that will forever change the way visitors see Chicago. TILT debuts in the spring of 2014, providing the ultimate window to the Windy City. A one-of-a-kind experience, TILT is an enclosed, glass and steel moveable platform that holds up to eight visitors per cycle. Once safely situated inside, the platform slowly tilts outward to an adventurous angle, generating downward-facing views of Chicago – from one thousand feet above The Magnificent Mile®. TILT gives thrill-seekers an exciting and safe way to take in unsurpassable views of the city, from a never-before-seen angle. Check website for opening dates and hours.
37 Bar & Grill at White Pines Golf Club
DuPage County, Chicago's Western Suburbs - Enjoy a variety of daily and weekly food and drink specials, along with craft beers offered on tap and by the bottle. Seasonal patio dining available, and the new bar area has sitting room for 38 guests, boasting multiple HDTV screens.
42nd Fall Fox Valley Antiques Show and Sale
Sat. 10-5; Sun. 10-4. Authentic antiques exhibited indoors at the Kane County Fairgrounds. Catered lunch is available. Plenty of free parking. Admission $8 benefits local historical, educational endeavors.
CITY:St. Charles
Great brewery tours, great beers, Taco Thursdays - you must see 5 Rabbit! The name 5 Rabbit was inspired by the Aztec culture of Latin heritage. 5 Rabbit beers are mysterious and captivating, and every taste reveals a new detail. Great for those seeking fresh, unique and delicious beers.
CITY:Bedford Park
Serious readers shop here for everything from the latest university press publications to children's classics. The Obama family is known to browse the store's extensive book collection.
An eclectic mix of new and vintage home furnishings and accessories. We are committed to offering sophisticated design to the savvy and urban-minded shopper.
We are an American Contemporary restaurant with excellent views of the Magnificent Mile.
720 SOUTH is a classic American grill featuring a seasonally inspired menu focusing on local ingredients. Unwind after a long day in the lounge with colleagues over locally crafted beers or enjoy an evening dinner with friends and family. Guests will enjoy signature comfort foods, classically inspired cocktails and an extensive selection of wines by the glass.
8000 Miles menu is comprised of Chinese and Japanese small plates. Guests looking for a custom experience can talk to their server about the Sichuan written menu with authentic gems. An entire sushi menu will be available featuring fresh nigiri and sashimi and unique maki plates along with a vast variety of fresh vegetable dishes. 8000 Miles will offer a select menu of homemade desserts and a Group Share menu will also be available for tables of six or more guests along with a Gluten Free and Kids Menus
The avenue's most fashionable address features an unprecedented shopping experience at Bloomingdale's flagship store, along with 70 fine shops and restaurants. Enjoy six levels of spectacular shopping at retailers like Coach, Gucci, Maxmara, and Mark Shale.
Watch as intricate rod puppets perform A Halloween Spooktacular. Featuring a collection of haunting classics from musicals. Reservations are required.
CITY:Rolling Meadows
A' Salute is a high class lounge featuring entertainment every Friday and Saturday night with room for dancing. The menu will feature a selection of small sandwiches called "trios" which are served in threes.
CITY:St. Charles
Skokie kosher restaurant exceeds the generally mediocre standards for kosher cuisine, with pizza and a good variety of meatless dishes.
A Taste of Heaven Bakery and cafe
This Andersonville cafe and bakery sells an array of rich treats: raspberry crumble bars, orange poppy seed cake, giant sugar cookies, and heavenly mini apple pies, not to mention scones tagged the best in town. Breakfast items include French toast, quiche, and a breakfast burrito; lunch and dinner entrees are homey--spinach lasagna, chicken potpie, soups, salads, and sandwiches with meat piled high on homemade bread. The room is cozy, with natural light streaming in through the windows.


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Per the Government Performance and Results Act Modernization Act of 2010, USAID and the Department of State developed FY 2014-2015 Agency Priority Goals (APGs), which were published along with the President's Budget in March 2014. There is one joint USAID/Department of State APG, three USAID-only APGs, and one State-only APG. These goals highlight USAID and the Department of State priorities and provide narrowly focused illustrations of these priorities to achieve measurable results.
The FY 2014-2015 APGs are now published on Performance.gov and accessible to the public.
Last updated: March 25, 2014


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Luxury sport utility vehicles are a good option for buying on the used market. Late model used luxury sport utility vehicles have the benefit of providing comfort and style at a lower price than new. And since luxury SUVs are some of the most powerful vehicles on the market, used SUVs are still fun to drive, even a few years after they've originally come off the dealer lot.
So what makes a luxury sport utility vehicle? One way to look at it is that they're sport utility vehicles that have been punched up in every way possible, to attract the attention of big spenders. Another way to think about them is as luxury cars that have spread out into an SUV body. It seems as if auto manufacturers have taken both approaches to designing luxury SUVs. Some seem more oriented toward the sport utility aspect; others seem to project the luxuriousness as a bigger and more important factor. When buying used, the vehicle's original marketing strategy might not be as persuasive as it was to new buyers (although it might still affect how a used vehicle is publically perceived). The features and options might be a little older, but most late model luxury sport utility vehicles will be built with high quality components that retain their value and still work well. The interior should still be in good condition, and so should the engine and other mechanical components. Even if it's lost its initial freshness, a potential new-to-you luxury SUV should still feel solid and work well. So it's important to weigh each used luxury sport utility vehicle model on its own merits, and not worry too much about why the previous owner might have bought it. It's much more useful to think about how the previous owner treated it and make sure your preowned luxury sport utility vehicle is still a cut above other luxury cars and other SUVs.


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Process Development Jobs Still the Most...
As Immunotherapy Revolutionizes the Cancer Treatment...
Quadruple Helices Appear To Have Role...
Wall Street Decline Takes Its Toll...
Abbott is paying Reata Pharmaceuticals $400 million up front as part of a worldwide collaboration to jointly develop and commercialize the latter's second-generation oral antioxidant inflammation modulator (AIM) portfolio. The deal expands the firms' existing agreement, signed in September 2010, under which Abbott has exclusive rights to develop and commercialize Reata's lead AIM compound, bardoxolone methyl (RTA 402), globally, excluding the U.S. and certain Asian markets. Bardoxolone methyl is currently undergoing a Phase III clinical study in patients with stage 4 chronic kidney disease and type 2 diabetes.
Under terms of the new deal Abbott and Reata will equally share costs and profits for all new AIMs in the majority of licensed indications, including pulmonary and central nervous system disorders, as well as immunology. Abbott will be responsible for 70% of the costs and retain 70% of the profits for AIM candidates developed for indications in rheumatoid arthritis and other selected autoimmune diseases. Clinical trials with the first compound are expected to start during 2012.
The firms have in addition established a research collaboration to discover new molecules that exhibit the same pharmacology as AIMs already in Reata's pipeline. "This deal helps Reata advance new molecules into clinical development in multiple important diseases and enables our company to build a global commercial presence," comments Warren Huff, CEO.
AIMs are transcription factor Nrf2 activators, designed to trigger the expression of a range of antioxidant, detoxification, and anti-inflammatory genes. Nrf2 activation also inhibits NF-KB, which regulates pro-inflammatory genes. Reata claims that Nrf2 suppression and NF-KB activation have been associated with a range of chronic diseases including multiple sclerosis, rheumatoid arthritis, chronic kidney disease, neurodegenerative disease, and COPD.
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WAILUKU - After running from a police officer seeking to arrest him on a warrant, a Kahului man was convicted of operating a stolen moped that he left behind.
A 2nd Circuit Court jury reached the verdict Wednesday morning, finding Ricky Magsayo, 33, guilty of unauthorized control of a propelled vehicle.
"Could it be any easier to tie it back to him?" Deputy Prosecutor Timothy Tate said during closing arguments to jurors Tuesday afternoon in the trial. "He's found in the driveway standing next to it."
The moped had been painted blue, with its mirrors gone, its ignition punched and its gas tank damaged when it was recovered in the early-morning hours of Oct. 24, 2011, from the driveway of Magsayo's residence on Honowai Street.
The vehicle had been black when it was reported stolen from Kihei on Oct. 9, 2011.
The next day, when police officer Clifford Dagulo stopped Magsayo for a traffic violation in front of his residence, he was driving a white Nissan sedan.
But over the next two weeks, Dagulo testified, he twice saw Magsayo, without a helmet or glasses, riding a blue moped in the Kahului area.
After learning there was a warrant for Magsayo's arrest, Dagulo said, he saw Magsayo standing next to the moped in front of his residence at about 1 a.m. Oct. 24, 2011. "I got an excellent look at him," said Dagulo, who had focused a spotlight on Magsayo.
By the time Dagulo made a U-turn to reach the residence and parked his police car, Magsayo was gone, the officer said. "He sprinted away from me," Dagulo said.
He said officers woke up Magsayo's parents and brother who were asleep in the home and got permission to search the residence but didn't find Magsayo inside. A police check of the vehicle identification number of the moped showed it was the one that had been reported stolen in Kihei.
In closing arguments, Deputy Public Defender Shelly Miyashiro said Magsayo wasn't seen operating the moped that night and was standing 5 feet away. "This, without more, is not enough to prove unauthorized control," Miyashiro said.
She said Dagulo couldn't give specific dates for the prior times that he testified he saw Magsayo operating a moped and couldn't show that it was the same moped that was found at the residence.
But Tate argued that the combination of direct and circumstantial evidence presented during the trial showed that Magsayo had been operating the moped without permission of its owner.
"The evidence all pointed to him," Tate said.
"I'm glad that the jury chose to convict this defendant and hold him accountable for the crime he committed," Tate said after the verdict. "When he is sentenced, I will be seeking a maximum prison sentence and consecutive prison sentences for his two cases."
According to court records, Magsayo is awaiting sentencing in another case after pleading no contest to charges of third-degree promotion of a dangerous drug, possessing drug paraphernalia and third-degree promotion of a detrimental drug.
Judge Joseph Cardoza presided over the trial this week.
Magsayo is scheduled to be sentenced June 18 on the unauthorized control of a propelled vehicle charge, which carries a penalty of up to five years in prison.
According to the Hawaii Criminal Justice Data Center, Magsayo has 12 convictions, dating to 1999, for crimes including abuse, first-degree burglary, second-degree theft, unauthorized entry into a motor vehicle, fourth-degree theft and first-degree criminal trespassing.
* Lila Fujimoto can be reached at firstname.lastname@example.com.


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Serves 4 |
Prep Time 10 minutes |
Cook Time 1 hour
1 medium cauliflower, cut into florets
1 large red onion, sliced into 1" thick wedges
4 cloves garlic, unpeeled
4 sprigs fresh thyme
4 Tbsp Eden Extra Virgin Olive Oil
1/2 tsp Eden Sea Salt
1/4 tsp garlic salt, or to taste
1/8 tsp black pepper, or to taste
Preheat the oven to 425°. Place all ingredients in a medium mixing bowl and toss to evenly coat the cauliflower and onions with oil and seasonings. Transfer to a large rimmed baking sheet and bake for 50 to 60 minutes or until tender and browned, tossing occasionally to evenly roast. Remove and place in a serving dish.
Variation: summer squash, zucchini, winter squash, potatoes, broccoli, turnips, carrots, sweet potatoes, yellow onions, rutabaga, leeks or other vegetables can be roasted in the same manner or some may be combined and roasted with cauliflower. Try different seasonings, as well, like rosemary, basil, oregano, etc. Cooking times may vary depending on thickness or hardness of individual vegetables.
American, Condiments, Gluten-Free, Macrobiotic, No Sweetener Added, Oils, Side Dish, Vegan, Wheat-Free


text:
Author Affiliations: Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, England (Drs Clarke, Lewington, Armitage, Bennett, Peto, and Collins and Mr Halsey); Population Health Research Institute and Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada (Dr Lonn); Department of Medicine, Harvard Medical School, Brigham and Women's Hospital (Dr Manson), and Massachusetts Veterans Epidemiology Research and Information Centre, Veterans Affairs Boston Healthcare System (Dr Gaziano), Boston, Massachusetts; Department of Heart Disease, University Hospital of Northern Norway, Tromsø (Dr Bønaa); Department of Neurology, Robarts Research Institute, University of Western Ontario, London, Ontario (Dr Spence); Department of Heart Disease, University of Bergen, Bergen, Norway (Dr Nygård); Department of Medicine, Veterans Affairs Palo Alto Healthcare System and Stanford University School of Medicine, Palo Alto, California (Dr Jamison); Cooperative Studies Program, Department of Veterans Affairs, Connecticut Veterans Affairs Healthcare System, West Haven (Dr Guarino); and Department of Clinical Pharmacology, Addenbrookes' Hospital, Cambridge, England (Dr Mir).
Elevated plasma homocysteine levels have been associated with higher risks of cardiovascular disease, but the effects on disease rates of supplementation with folic acid to lower plasma homocysteine levels are uncertain. Individual participant data were obtained for a meta-analysis of 8 large, randomized, placebo-controlled trials of folic acid supplementation involving 37 485 individuals at increased risk of cardiovascular disease. The analyses involved intention-to-treat comparisons of first events during the scheduled treatment period. There were 9326 major vascular events (3990 major coronary events, 1528 strokes, and 5068 revascularizations), 3010 cancers, and 5125 deaths. Folic acid allocation yielded an average 25% reduction in homocysteine levels. During a median follow-up of 5 years, folic acid allocation had no significant effects on vascular outcomes, with rate ratios (95% confidence intervals) of 1.01 (0.97-1.05) for major vascular events, 1.03 (0.97-1.10) for major coronary events, and 0.96 (0.87-1.06) for stroke. Likewise, there were no significant effects on vascular outcomes in any of the subgroups studied or on overall vascular mortality. There was no significant effect on the rate ratios (95% confidence intervals) for overall cancer incidence (1.05 [0.98-1.13]), cancer mortality (1.00 [0.85-1.18]) or all-cause mortality (1.02 [0.97-1.08]) during the whole scheduled treatment period or during the later years of it. Dietary supplementation with folic acid to lower homocysteine levels had no significant effects within 5 years on cardiovascular events or on overall cancer or mortality in the populations studied.
Elevated plasma total homocysteine has been suggested as a potentially modifiable risk factor for coronary heart disease (CHD), stroke, and other occlusive vascular conditions.1- 4 High rates of cardiovascular disease (CVD) in untreated children with homocystinuria (a rare autosomal recessive condition with plasma homocysteine levels greater than 100 μmol/L [to convert to milligrams per liter, divide by 7.397]) prompted the homocysteine hypothesis, which states that moderate elevations of homocysteine levels may be relevant to CVD in the general population.5 Early observational studies reported that patients with CHD or stroke have 3- to 5-μmol/L higher measured homocysteine levels than age- and sex-matched controls,1- 3 and a 1995 meta-analysis of such studies reported that a 5-μmol/L higher homocysteine level (eg, 15 vs 10 μmol/L) was associated with a 70% higher risk of CHD.2 Subsequently, however, prospective cohort studies of homocysteine reported more modest associations.3,4 In 2002, a collaborative meta-analysis involving individual data from prospective studies reported that, after adjustment for known cardiovascular risk factors, a 25%-lower usual plasma total homocysteine level was associated with an 11% (95% confidence interval [CI], 4%-17%) lower risk of CHD and 19% (5%-31%) lower risk of stroke.4
In patients with homocystinuria, supplementation with B vitamins has been shown to lower homocysteine levels and the risk of CVD.5,6 A meta-analysis of randomized trials found that, in populations without folic acid fortification, supplementation with folic acid lowered homocysteine levels by 23% or, if given in combination with vitamin B12 (cyanocobalamin), by 30%.7 The effects of B-vitamin supplementation were somewhat less pronounced in populations with preexisting mandatory folic acid fortification, but, even there, the combination therapy typically lowered homocysteine levels by 20%.7
Many large randomized trials of B-vitamin supplementation in patients at high risk of or with established CVD have been conducted to test the homocysteine hypothesis.8- 19 Several of those trials (guided by reviews of the early observational studies2,3) were designed to detect reductions in CHD risk of more than 30%, so they lacked statistical power to detect more modest, but still potentially important, effects.20 Consequently, a collaboration between their investigators was established in 2004 to conduct a meta-analysis based on individual participant data from all large randomized trials of folic acid–based B-vitamin supplementation intended to lower plasma homocysteine levels for the prevention of CVD.20,21 The present report describes the effects on cause-specific major morbidity and mortality from the 8 such trials that had been completed by the end of 2009.8- 15
Randomized trials were eligible if (1) they involved a double-blind randomized comparison of B-vitamin supplements containing folic acid vs placebo for the prevention of vascular disease (irrespective of whether any other treatment was administered factorially); (2) the relevant treatment arms differed only with respect to the intervention to lower homocysteine levels (ie, they were unconfounded); and (3) the trial involved at least 1000 participants for a scheduled treatment duration of at least 1 year. Unpublished trials were sought through electronic searches and discussions with other experts in the field, but none was found. Individual participant data were obtained from 37 485 participants from all 8 available trials completed by the end of 2009. Data are not yet available from 3 unpublished trials involving almost 15 000 participants with prior CVD or renal disease, and these are not expected to report their results before late 2010.16- 18 Another trial that intended to involve 15 000 participants with hypertension only started enrollment in 2008.19
For each randomized participant, information was sought on characteristics recorded before randomization, the randomly allocated treatment, and the type and date (or time from randomization) of any systematically recorded outcomes occurring during the scheduled treatment period. Information on adverse events, including hospitalizations and cancer incidence, was collected in each trial at typically 3- to 6-month intervals during the scheduled treatment period. In addition to self-reported cancer, additional data on cancer incidence were obtained from national cancer registries in some trials.10,14,15 Trial coordinators sought verification of all study-related outcomes from hospital electronic records or by writing to hospital or family physicians. Analyses of the individual patient data were checked for consistency with any published reports (and with the trialists) to help ensure that the data were incorporated correctly into the meta-analysis. Investigators were also asked to confirm summary data for each treatment group on the number of randomized patients; on plasma levels of total homocysteine, folate, and vitamin B12 before and after starting treatment; and on the numbers of patients who developed each of the predefined outcomes.
All events were prespecified and defined using standard criteria in the protocol for this meta-analysis.21 The main outcomes were major vascular events (defined prospectively as major coronary events, strokes, or coronary and noncoronary artery revascularizations), cancer incidence, and total and cause-specific mortality.
Major coronary events were defined as the first occurrence of nonfatal myocardial infarction or coronary death (including death from heart failure and sudden or unexpected deaths considered coronary in origin). Strokes were the first occurrence of ischemic, hemorrhagic, or unclassified stroke (but not just transient cerebral ischemia). Coronary revascularizations involved coronary artery bypass grafting or coronary angioplasty (with or without stent insertion), and noncoronary revascularization included carotid artery endarterectomy or angioplasty, repair of aortic aneurysm, peripheral arterial surgery, or noncoronary angioplasty. Incident cancers were the first occurrence after randomization of any new cancers excluding (where possible) nonfatal nonmelanoma skin cancers. Having individual participant data from each trial allowed outcomes to be recoded uniformly using these definitions.
Comparisons were intention-to-treat, time-to-event analyses of first events of a particular type occurring during the scheduled treatment period among all patients allocated to folic acid vs all allocated to the control treatment. The log-rank observed minus expected (o − e) statistics and their variances (v) from each trial were summed to produce, respectively, a grand total observed minus expected statistic (G) and its variance (V).22,23 The 1-step estimate of the logarithm of the event rate ratio is then G /V with variance 1/ V (and 95% CI [G /V ] ± [1.96/ V1/2]). For n trials, the χ2 statistic for heterogeneity with n − 1 degrees of freedom (χ2n − 1) is S − (G2/ V), where S is the sum over all the trials of (o − e)2/ v.22,23 The effects on vascular outcomes were assessed in the following predefined subgroups21: sex, age, approximate thirds of pretreatment blood levels of folate (<4.4, 4.4-7.9, and >7.9 ng/mL [to convert to nanomoles per liter, multiply by 2.266]) or of homocysteine (<11, 11-14, and ≥15 μmol/L), mandatory folic acid fortification, years since randomization, baseline smoking (current/not), alcohol consumption (current/not), presence of diabetes mellitus, statin use, aspirin use, body mass index (calculated as weight in kilograms divided by height in meters squared) (<25.0, 25.0-29.9, and ≥30.0), and approximate thirds of serum creatinine levels (<0.90, 0.90-1.06, and ≥1.07 mg/dL [to convert to micromoles per liter, multiply by 88.4]). Heterogeneity of the rate ratios (RRs) among these prespecified subgroups was investigated by a global test to reduce the chance of misinterpreting false-positive results arising from multiple comparisons.23 The CIs used were 99% for individual trials or subgroups and 95% for the overall estimates. In addition, the RR for major vascular events in each trial was plotted against the percentage homocysteine reduction achieved in that trial. The mean percentage homocysteine reduction in the aggregate of all trials was calculated as the weighted mean of the study-specific percentage reductions, with weights equal to the variances of the log-rank statistics for major vascular events. Analyses used commercially available software (SAS, version 9.1; SAS Institute Inc, Cary, North Carolina).
Selected characteristics of the 8 randomized trials are shown in Table 1. Four trials recruited individuals with prior CHD,8,10,14,15 1 with prior stroke,9 2 with prior CVD or increased risk of CVD,11,13 and 1 with advanced renal disease (in which plasma homocysteine levels were particularly high).12 Six trials8- 11,14,15 recruited partly or entirely from nonfortified populations (22 371 individuals; 6311 major vascular events), and 49,11- 13 recruited partly or entirely from fortified populations (15 114 individuals; 3015 major vascular events). Morbidity and mortality follow-up were more than 99% complete in 4 trials10,11,14,15 but ranged from 93% to 97% in the others.8,9,12,13 The median duration of treatment in the different trials varied from 2.0 to 7.3 years, with an overall median of 5.0 years. All trials compared the effects of folic acid with placebo, except 1 trial9 that compared 2.5 mg with 20.0 μg of folic acid (which is approximately equivalent to a placebo because this dose is less than one-tenth of the daily dietary intake of folic acid). The doses of folic acid ranged from 0.8 to 5.0 mg/d, except in 1 trial that used 40.0 mg/d.12 All but 1 trial8 added vitamin B12 (dose range, 0.4 to 2.0 mg) to the folic acid, and all but 28,15 also added vitamin B6 (pyridoxine hydrochloride). Two-thirds of the participants were men, the mean (SD) age at entry was 65 (10) years, 18% were current smokers, 20% had diabetes mellitus, and 30% were obese (defined as a body mass index of ≥30.0) (eTable 1).
Table 2 shows the effect of folic acid allocation on the median postrandomization plasma levels of folate and total homocysteine. Overall, there was a 25% reduction in homocysteine levels, which was maintained on average for 5 years. As expected, allocation to folic acid was associated with slightly smaller relative and absolute reductions of homocysteine levels in folate-fortified compared with non–folate-fortified populations (22% vs 27% relative reductions; P < .001 for differences between these percentages).
Among all 37 485 participants in all 8 trials, 9326 had a major vascular event during the scheduled treatment period (Table 3 and eTable 2). Allocation to folic acid treatment had no significant effect on major vascular events, with 4670 (24.9%) first events among the 18 723 participants allocated to folic acid vs 4656 (24.8%) among the 18 762 allocated to placebo (RR, 1.01; 95% CI, 0.97-1.05; P = .6) (Figure 1). There was no significant effect on the numbers of participants having major coronary events, with 2019 (11.4%) vs 1971 (11.1%) first MCEs (RR, 1.03; 95% CI, 0.97-1.10; P = .3). Moreover, there was no significant effect in these trials on the risk of stroke, with 747 (4.2%) vs 781 (4.4%) first events (RR, 0.96; 95% CI, 0.87-1.06; P = .4). There was no significant effect on ischemic stroke (RR, 0.96; 99% CI, 0.81-1.14), hemorrhagic stroke (RR, 1.08; 99% CI, 0.66-1.77), or unclassified stroke (RR, 0.94; 99% CI, 0.75-1.18). Finally, there was no significant effect on arterial revascularization (RR, 1.00; 95% CI, 0.94-1.05) or on coronary revascularization or MCE (RR, 1.01; 95% CI, 0.96-1.06).
Effects of folic acid on first major vascular events. (Some people had more than 1 type of major vascular event.) The black squares denote the rate ratios (RRs) and horizontal lines the 99% confidence intervals (CIs). Each square has an area inversely proportional to the variance of the logarithm of the RR. The diamonds represent the summary estimates and their corresponding 95% CIs. CHD indicates coronary heart disease; MI, myocardial infarction.
Despite substantial differences between the trials in pretreatment plasma folate status and folic acid doses, there was no significant difference between the proportional effects on major vascular events in the individual trials (χ27 for heterogeneity, 8.09; P = .3) (Figure 2). There was no suggestion of beneficial effects even in those trials that achieved larger homocysteine level reductions (Figure 3). No significant effect was observed in any of the prespecified subgroups, including those defined by sex, age, pretreatment levels of folate or homocysteine, or population-level fortification status (global χ25 for heterogeneity, 1.78; P = .9) (Figure 2).The one-third of participants with the highest baseline homocysteine levels (mean, 21 μmol/L) experienced the greatest reduction in homocysteine levels (about 6 μmol/L), but even among these, folic acid allocation was not associated with any significant effect. There was no trend of increasing benefit with increasing duration of treatment (χ21, 0.48; P = .5). Likewise, no significant effect was found on major vascular events in further exploratory subgroup analyses (global χ27 for heterogeneity, 7.41; P = .4) (eFigure 1). Finally, analyses of major coronary events only (eFigure 2) or of stroke only (eFigure 3) found no apparent effects in any of the prespecified subgroups.
Effects of folic acid on major vascular events in prespecified subgroups (global test for heterogeneity, χ25 = 1.78; P = .9). Symbols and conventions are given in Figure 1. To convert folate to nanomoles per liter, multiply by 2.266; homocysteine to milligrams per liter, divide by 7.397. CHAOS-2 indicates Cambridge Heart Antioxidant Study 2; HOPE-2, Heart Outcomes Prevention Evaluation 2; HOST, Homocysteinemia in Kidney and End Stage Renal Disease; NORVIT, Norwegian Vitamin Trial; SEARCH, Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine; VISP, Vitamin Intervention for Stroke Prevention; WAFACS, Women's Antioxidant and Folic Acid Cardiovascular Study; and WENBIT, Western Norway B Vitamin Intervention Trial.
Effects of folic acid on major vascular events by percentage reduction in plasma total homocysteine levels. The black squares denote the rate ratios (RRs) and vertical lines the 99% confidence intervals (CIs). Each square has an area inversely proportional to the variance of the logarithm of the RRs. Other abbreviations are given in Figure 2.
Data were available on 3010 people with incident cancers that occurred after randomization among the 35 603 individuals included in the 7 randomized trials that collected such data.9- 15 Allocation to folic acid was not associated with any significant difference in the overall incidence of cancer, with 1541 new cases (8.7%) among the 17 783 participants allocated to folic acid vs 1469 (8.2%) among the 17 820 allocated to placebo (RR, 1.05; 95% CI, 0.98-1.13; P = .14) (Figure 4). There was no significant difference between the proportional effects on cancer in any of the individual trials (χ26 for heterogeneity, 4.68; P = .6), despite the doses of folic acid ranging from 0.8 to 40.0 mg/d. Even among patients who received folic acid treatment for more than 5 years, there was no suggestion of any effect on cancer rates beginning to emerge with longer duration of treatment (χ21 for trend, 0.01; P = .9), in the other prespecified subgroups (global χ25 for heterogeneity, 5.90; P = .3) (Figure 4), or in further exploratory subgroups (global χ27 for heterogeneity, 7.84; P = .4) (eFigure 4s).
Effects of folic acid on cancer incidence in prespecified subgroups (global test for heterogeneity, χ25 = 5.90; P = .3). Symbols and conventions are given in Figure 1. Other abbreviations and SI conversion factors are given in Figure 2.
Data were available on 5125 deaths among the 37 485 randomized participants. Allocation to folic acid was not associated with any significant differences in total mortality, with 2578 deaths (13.8%) among the 18 723 participants allocated to folic acid vs 2547 deaths (13.6%) among the 18 762 allocated to placebo (RR, 1.02; 95% CI, 0.97-1.08; P = .46) (Figure 5). Consistent with the lack of any apparent effect on major vascular events, there were no significant effects on mortality from CHD (RR, 1.02; 99% CI, 0.90-1.16; P = .65), stroke (RR, 0.92; 99% CI, 0.67-1.25; P = .47), or other vascular causes (RR, 0.99; 99% CI, 0.83-1.18; P = .85). Similarly, consistent with the lack of any apparent effect on cancer incidence, there was no significant effect on cancer mortality (RR, 1.00; 99% CI, 0.85-1.18; P = .99).
Effects of folic acid on cause-specific mortality. Symbols and conventions are given in Figure 1. CHD indicates coronary heart disease.
The present meta-analysis has demonstrated that lowering homocysteine levels by an average of 25% (about 3 μmol/L) for an average of 5 years has no significant effect on the incidence of major vascular events during the scheduled treatment period. With 9326 such events among 37 485 individuals, this collaboration had more than 99% power to detect the 10% reduction that might plausibly have been anticipated from the observational studies if the association of homocysteine with major vascular events seen in those studies was causal and if protection emerges within just a few years.4,20
Observational studies have found stronger associations of homocysteine with stroke than with CHD4 and in women than in men.4 Based on secular trends in the United States and the United Kingdom, the greater reduction in stroke mortality from 1990 through 2002 in the United States had been tentatively attributed to the introduction of folic acid fortification,24 although this is not supported by reexamination of the trends in stroke mortality in middle age (35-69 years; trends at older ages may be less reliable).25 A previous meta-analysis of published results from some of the folic acid trials involving a total of 778 first strokes reported that folic acid could reduce the risk of stroke.26 By contrast, this meta-analysis of individual patient data involving 1528 first strokes found no significant effects on stroke. Folic acid did not produce significant effects on major vascular or coronary events in those presenting with low blood folate levels or with high blood homocysteine levels.
The doses of folic acid used in all the trials included in this meta-analysis exceeded those required for near-maximal reduction in homocysteine levels.7 In addition, all except 1 trial8 used vitamin B12, which further reduces homocysteine levels (and, with a dose of at least 1.0 mg/d in 4 trials,11- 13,15 should also correct for any undetected vitamin B12 deficiency27). The randomized trials in the present meta-analysis found no evidence of benefit with treatment continued for more than 5 years. Although some benefit might emerge with even longer treatment and follow-up, the trial results give no reason to expect this (particularly because cardiovascular benefits tend to emerge within just a few years with other cardioprotective treatments, such as antihypertensives28 or statins29). Thus, the meta-analysis indicates that supplementation with folic acid has little or no beneficial effect on coronary disease, stroke, or mortality during the 5 years of supplementation. In contrast with previous reviews30,31 based on summary results of these trials (but excluding the largest15), the use of individual participant data from these trials allows the present report to provide results for a broader range of vascular and nonvascular outcomes and to explore the effects of B vitamins in relevant subgroups reliably. It is unlikely that findings from ongoing trials will differ much from those of this meta-analysis; so, the addition of their results is likely only to improve the precision of the estimates around the lack of benefit.16- 19 Although trials of folic acid supplementation suggest no reduction in CHD or stroke associated with an average 25% reduction in homocysteine levels maintained for a median duration of 5 years, the lower confidence limits are compatible with a 3% reduction in CHD risk and a 13% reduction in stroke risk—and, if there is any real effect, the effects of lifelong differences could be somewhat larger.
Some observational studies have reported that folate status is inversely related to the risk of colorectal cancer32 and breast cancer.33 Conversely, it has also been suggested that increasing folic acid intake might increase the rate of transformation of adenomas into cancers or of small cancers into larger ones.34 An analysis of trends in colorectal cancer incidence in the United States and Canada from 1986 through 2002 indicated a transient reversal in the downward trends that coincided with the introduction of folic acid fortification in 1996, and it was suggested that this might be causal35; again, however, this is not confirmed by reexamination of the national mortality trends at ages 35 to 69 years.25 Three trials of folic acid supplementation involving a total of 2652 participants with a history of colorectal adenoma (and so not eligible for the present meta-analysis) have reported conflicting results on the recurrence of adenomas and on cancer incidence.36- 39 An analysis of the 6-year follow-up of 6837 participants with a history of CHD in 2 Norwegian trials included in the meta-analysis also suggested that folic acid plus vitamin B12 might increase overall of cancer incidence and mortality.40 By contrast, based on 3010 incident cancers among 35 603 individuals, the present meta-analysis did not find any significant adverse effect of folic acid on cancer incidence overall or in any prespecified subgroup. There was no heterogeneity in the effects on incident cancer by dose of folic acid, which ranged from 0.8 to 40.0 mg/d. For example, the 40.0-mg/d folic acid dose studied in the Homocysteinemia in Kidney and End Stage Renal Disease trial produced a 100-fold increase in plasma folate level but had no apparent adverse effect on cancer incidence.12 Even with more than 5 years of treatment, there was no evidence of any emerging effect on overall cancer incidence. Moreover, the absence of heterogeneity in the effects of folic acid on cancer incidence in the different trials refutes concerns about any differential effects of folic acid in trials that relied on self-reported cancer events compared with those that also included surveillance by cancer registries. (The present meta-analyses do not address the possibility of effects on some particular types of cancer, which will be considered in a separate report.)
One-third of adults in the United States41 and one-quarter of those in the United Kingdom42 report taking daily multivitamin supplements containing folic acid. The present meta-analysis, however, found no evidence that routine use of folic acid for 5 years has any material effect on cardiovascular or noncardiovascular events in the North American and European populations studied. The doses of folic acid used in these trials (0.8-40.0 mg/d) were substantially greater than the mandatory folic acid fortification adopted in the United States (140 μg per 100 g of cereal grain products; approximately equivalent to 0.1 mg/d of folic acid) for the prevention of neural tube defects.43,44 Although the lack of any other benefits is disappointing (albeit faily definitive), the lack of any significant adverse effects on vascular events, cancer incidence, cancer mortality, and overall mortality provides reassurance about the safety of population-wide folic acid fortification.
Correspondence: Robert Clarke, FRCP, Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Building, University of Oxford, Old Road Campus, Oxford OX3 7LF, England (email@example.com).
Accepted for Publication: June 7, 2010.
Author Contributions: The authors accept full responsibility for the content of this article. Study concept and design: Clarke, Lonn, Armitage, Manson, Bønaa, Spence, Nygård, Jamison, Gaziano, Guarino, Mir, and Collins. Acquisition of data: Clarke, Lonn, Armitage, Manson, Bønaa, Spence, Nygård, Jamison, and Gaziano. Analysis and interpretation of data: Clarke, Halsey, Lewington, Lonn, Manson, Armitage, Bønaa, Nygård, Jamison, Bennett, Peto, and Collins. Drafting of the manuscript: Clarke, Lewington, Mir, Peto, and Collins. Critical revision of the manuscript for important intellectual content: Halsey, Lewington, Lonn, Manson, Bønaa, Spence, Nygård, Jamison, Gaziano, Guarino, Bennett, and Collins. Statistical analysis: Halsey, Lewington, Guarino, Bennett, Peto, and Collins. Obtained funding: Clarke, Lonn, Bønaa, Spence, Nygård, Jamison, and Gaziano. Administrative, technical, and material support: Clarke, Halsey, Armitage, Manson, Bønaa, Nygård, Jamison, Gaziano, Bennett, and Collins. Study supervision: Clarke, Lonn, Bønaa, Jamison, Mir, and Collins.
B-Vitamin Treatment Trialists' (BVTT) Collaboration: Fraz Mir, MD, and Morris Brown, MD (Cambridge Heart Antioxidant Study 2); Eva Lonn, MD, and Salim Yusuf, MD (Heart Outcomes Prevention Evaluation 2); Kaare H. Bønaa, MD, and Inger Njolstad, MD (Norwegian Vitamin Trial); Jane Armitage, FRCP, Louise Bowman, MD, Robert Clarke, FRCP, Sarah Parish, DPhil, Richard Peto, FRS, and Rory Collins, FRCP (Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine); Rex Jamison, MD, J. Michael Gaziano, MD, and Peter Guarino, PhD (Homocysteinemia in Kidney and End Stage Renal Disease); James Toole, MD, M. Rene Malinow, MD (deceased), L. Creed Pettigrew, MD, J. David Spence, MD, Virginia J. Howard, MD, Elizabeth G. Sides, MEd, Chin H. Wang, PhD, and Meir Stampfer, MD (Vitamin Intervention for Stroke Prevention); JoAnn E. Manson, MD, DrPH, Robert Glynn, PhD, Francine Grodstein, MD, Christine M. Albert, MD, and Nancy R. Cook, ScD (Women's Antioxidant and Folic Acid Cardiovascular Study); Ottar Nygård, MD, Marta Ebbing, MD, Jan E. Nordrehaug, MD, Dennis W. T. Nilsen, MD, Hegla Refsum, MD, and Stein E. Vollset, MD (Western Norway B Vitamin Intervention Trial); BVTT secretariat: Robert Clarke, FRCP, Jim Halsey, BSc, Sarah Lewington, DPhil, Derrick Bennett, PhD, and Rory Collins, FRCP.
Financial Disclosure: Dr Gaziano reports receiving investigator-initiated research funding from the National Institutes of Health, the US Department of Veterans Affairs, Veroscience, and Amgen and pills and packaging for a research study from BASF, DSM, and Wyeth. He reports serving as a consultant to Bayer and having served as a medical expert for Merck.
Funding/Support: Sources of funding for the individual trials are described in their separate publications. The Clinical Trial Service Unit and Epidemiological Studies Unit, where the BVTT Secretariat is located, has a policy of not accepting fees, honoraria, or paid consultancies directly or indirectly from industry. It receives funding from the British Heart Foundation, UK Medical Research Council, and Cancer Research UK. Support for this project was also provided by a grant from the UK Food Standards Agency.
This article was corrected online for typographical errors on October 11, 2010.
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text: The Zen Center of Portland is a community dedicated to Zen practice in our daily lives. We are affiliated with the Ordinary Mind Zen School, which intends to manifest and support practice of the Awakened Way, as expressed in the teaching of Charlotte Joko Beck. We offer beginner's instruction, interviews with the teacher, eight sittings a week, all-day sits once a month, and meditation retreats several times per year. Please join us. Everyone is welcome. We are wheelchair accessible.


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Vacation Bible School- Faith Baptist Chapel in Napoleon
Grab your tickets and head on over to Faith Baptist Chapel¹s ColossalCoaster World� Vacation Bible School! Come join us as we experience the thrill and excitement of a day at the park! As we explore the park, kids will enter Worship Rally at the Main Gate and make their first stop at Coaster Alley for Bible study. While touring the park, kids will experience missions, crafts, music and of course we¹ll find time for snacks!
Faith Baptist Chapel¹s Vacation Bible School in Napoleon, on the corner of M-50 and Wheaton Road, is an experience like you¹ve never experienced before! Children starting kindergarten through completion of 6th grade are admitted free from July 22-26, from 6:00 9:00pm.
Preregistration is available at www.faithbapchap.org, or contact the church office at 517-536-4440 with question. This week of fun, food, and exciting learning opportunities is free of charge and open to everyone.


text:
Snakes Ambush Cubs at Ramada Field
Sergio Alcantara belted a two-run triple, Daniel Palka ripped an RBI triple, and Jose Munoz laced an RBI double to highlight a five-run 8th, Chuck Taylor doubled, singled twice, stole a base, and scored three runs, and Brad Keller and four relievers combined to throw a three-hit shutout, as the Diamondbacks blanked the Cubs 7-0 in Arizona Instructional League action this morning at Ramada Field at Salt River Fields at Talking Stick Resort east of Scottsdale.
After Keller threw three scoreless innings (allowing two doubles and three walks with three strikeouts), RHP Joe Martinez (3.0 IP, 1 H, 0 R, 0 BB, 5 K), LHP (ex-OF) Wagner Mateo, RHP Thomas Brendel, and RHP Jimmie Sherfy (1.0 IP, 0 H, 0 R, 0 BB, 2 K) totally stifled the Cubs hitters, collectively retiring 17 of the last 18 men they faced, with seven strikeouts.
Here is the abridged box score from today's gamer (Cubs players only):
1. Shawon Dunston Jr, CF: 1-4 (4-3, 2B, K, L-6)
2. Danny Lockhart, 2B: 1-4 (2B, K, K, E-6, SB)
3. Jeimer Candelario, 3B: 0-4 (3-1, 4-3, K, K)
4. Yasiel Balaguert, RF: 0-4 (6-3, K, F-8, K)
5. Ben Carhart, 1B: 0-3 (BB, P-4, 4-3, 6-3, CS)
6a. Gleyber Torres, SS: 0-3 (K, 6-3, F-9)
6b. Carlos Penalver, SS: NO AB
7. Jose Dore, LF-DH: 0-2 (BB, K, F-7)
8a. Cael Brockmeyer, C: 0-1 (BB, K)
8b. Mark Malave, C: 0-1 (F-7)
9. Charcer Burks, DH-LF: 1-3 (F-9, 1B, F-9, PO)
1. Daury Torrez: 3,0 IP, 3 H, 1 R (1 ER), 0 BB, 0 K, 1 GIDP, 6/3 GO/FO, 32 pitches (26 strikes)
2. Jose Rosario: 3.0 IP, 2 H, 1 R (1 ER), 0 BB, 3 K, 4/2 GO/FO, 42 pitches (27 strikes)
3. Trevor Graham: 1.0 IP, 3 H, 3 R (3 ER), 0 BB, 2 K, 1/0 GO/FO, 31 pitches (17 strikes)
4. Zack Godley: 1.0 IP, 2 H, 2 R (2 ER), 0 BB, 1 K, 1 WP, 2/0 GO/FO, 20 pitches (13 strikes)
3B Jeimer Candelario - E-5 (fielding error allowed batter to reach base safely)
Cael Brockmeyer: 0-1 CS
WEATHER: Sunny, cloudless, and breezy, with temperatures in the 80's
Any hits yet for Gleyber?
Any hits yet for Gleyber? Looking mismatched so far?
even though it'd be nice to
even though it'd be nice to see him do well out of the gate, he does still have the handicap of being 16 (17 in December). he's playing against a lot of guys 2-6+ years older than him.
it's hard enough to gauge players before they're out of A-ball...it's almost impossible with a guy this young aside from his raw tools, which you can learn a lot more about from watching him do drills than in-game stuff when your competition is so skewed in experience and age. i can't imagine he's seen much quality breaking stuff in his short life.
it's kinda weird to have a semi-high-profile signing like this and knowing it'll probably be 6-8 years before we have a handle on if he'll be a MLB impact player...and whether that will be as a starter or bench player.
AZ Phil, has Eloy Jimenez
AZ Phil, has Eloy Jimenez played yet?
AZ Phil: What does Wes
AZ Phil: What does Wes Darvill eventually project to in your opinion. Why do you think they put him on the AFL roster (what are THEY looking for wrt him).
"but now I think he might
"but now I think he might have a chance to make it to MLB as an IF-OF super-sub"
In other words, a potential starting infielder for the Cubs for the next 2 or 3 years.
That comment be fighting
That comment be fighting words...Trying to start the Riot?
Boston Globe leads his sunday
Boston Globe leads his sunday column with Girardi speculation wrt the Cubs. Also mentions the Cubs as a potential landing spot for Bronson Arroyo.
Liriano -
Liriano -
Was there any discussion last off-season or rumor that the Cubs were going to make a play on Francisco Liriano? He certainly is a bargain for the Pirates. And fucking good.
Seems like not only did he fit TheoCorp's budget parameters, but could have been a nice upgrade to Scott Baker (well, I could have been an upgrade to Scott Baker) or some of the non-existing starting AAA pitchers.
per Kaplan, Manny Acta
per Kaplan, Manny Acta getting Cub skipper interview today. Also a new name on the list: Friars bench coach Rick Renteria
Thanks CUBSTER.
Thanks CUBSTER.
Might as well interview the entire over-achieving Padres coaching staff. A good fit for the Cubs. And cheap, too!
WSCR Bernsein tweeting
WSCR Bernsein tweeting Girardi "saying family considerations will out weigh money"
If his wife is like any other she won't let him leave that much money on the table that Cubs are offering over the Yanks.
JG's wife, nee Kimberly
JG's wife, nee Kimberly Innocenzi's family lives in the north shore suburbs.
I'd say that's what the turning point of the discussion will hinge upon. It might come down to a mother-in-law issue. As in, the grandparents want to see the kids grow up.
m.wacha perfect through 5..
m.wacha perfect through 5...walks the 1st batter in the 6th.
no hitter gone after 7.1 with
no hitter gone after 7.1 with a p.alvarez solo HR.
fuji played catch today..
fuji played catch today...should be throwing rather soon.
fuji #1) http://www
fuji #1) http://thejoesweeney
Jose Ceda released by the
Jose Ceda released by the Marlins today. You may recall the Cubs sent him to FLA for Kevin Gregg in Nov 2008.
...and got him for Todd Walker from Padres in July 2006.
He was a power arm back in the day. He turns 27 in January.
"Andrew Marchand of
"Andrew Marchand of ESPNNewYork.com reports that that Yankees are "prepared to give Joe Girardi as much time as he needs" to make a decision about their contract offer.
Girardi's contract officially runs out at the end of the month, and Marchand says the club is willing to wait that long. The Yankees have reportedly offered the skipper a three-year deal in the $12-15 million range, but they could get into a bidding war with the Cubs, who have set their sights on Girardi."
cubs get into a bidding war...for someone who isn't going to swing a bat or throw a ball.
hopefully there's more rumor than truth to all this girardi stuff. sure, he's good, but if it comes at the expense of a top relief arm or the difference between an anibal sanchez and an edwin jackson type contract for playing talent...well, wtf?
i saw a lot of things wrong with the 2012 + 2013 cubs and the "fix list" didn't start with the guy in the dugout.
Are you trying to imply that
Are you trying to imply that the Cubs shouldn't spend a lot of money on a manager? You're being a bit too opaque.
i think it's an absolutely
i think it's an absolutely brilliant use of money. the team would have to spend 3x as much on an actual player to get the amount of fan-love return on it.
he's shown that if you give him $1,600,000,000 worth of team to manage, he'll get 1 WS out of it...so the cubs should sign him to a 16 year deal. that's simple swordmetrics (Some Wacky Obtuse Random Determination).
besides, if they don't sign him a cubs player might yell at a reporter or smash a boom box or something. though, i'm sure joel sherman won't mind.
That's much more transparent,
That's much more transparent, thanks!
It strikes me that players
It strikes me that players are overpaid relative to managers, probably because players have agents and a union.
The Yankees have been paying Girardi Theriot money.
Managers work for GMs, who also don't have agents and a union. In theory, a manager should not make more than the GM (let alone the president of baseball operations). It's interesting that Girardi will be pushing up against what Cashman and Epstein make.
I'm dubious the Cubs will trade for Price - two years of work building up the farm system would be practically undone overnight for one high-paid player with two years of club control? Even if the endgame is to give Price a nine-figure extension - Seems unlikely.
Trade Samardzija for
Trade Samardzija for prospects, use those prospects and a few current ones not named Soler, Almora, Baez, or Bryant to get Price would probably be the play.
Recent comments
Hopefully Pirates don't call up A. Lincoln.
j.buchanan going friday...should be...baseball...or something like it.
Wow. I didn't know they could do that.
Nice for Willson, not so much for Addy.
Game is officially called...also officially a tie.
Stats count, no make-up date of course.
Yeah -- seeing the weather -- I hope KB and Rizz are inside, wrapped in blankets and drinking hot chocolate.
rain delay...thanks obama.
Thanks again Phil. We actually were in Mesa and drove around. Hopefully, I am back for some Fall League. If not I have all of spring training (like the smart people who move here!)
What Rob G said. I can't speak for Piittsburgh, but the other end of the state has had absolute crap weather for two days. Perfect day to take it easy.
tarp came off 10 minutes ago...let's do this.
He will not pitch another game for Cubs
/Unless injury in playoffs
Today is bullpen day
10/450 if they win WS
Carrie Muskat [email protected]
Even though Hammel is missing start, don't assume he'll not be on #Cubs postseason roster. Maddon says elbow problem isn't that bad
Carrie Muskat [email protected]
Maddon on #Cubs postseason rotation: "I don't want to announce anything. We haven't talked to anybody yet"
Carrie Muskat [email protected]
Maddon hopes Soler can take BP in Cincy, play in sim game Tue. "All of that should give us some kind of indication of where he's at"
tarp on the field 40 minutes before gametime...meh.
travel day + rain in Pittsburgh. Why risk injury?


text:
Let me add my welcome too, DG........we're a fun lot, hope you enjoy it here!!! 42
Let me add my welcome too, DG........we're a fun lot, hope you enjoy it here!!! 42
Thanks for the welcome!
It is SO hard for me to name favorites. Of course I enjoy all the top skaters that everyone else does, but really don't claim to love any one more than any other.
I guess the excitement for me is watching truly inspired performances. From what we've all heard, this weekend's TV viewing should be great for that!
I also love seeing up and coming skaters "pushing" the top skaters to continually improve. I've always enjoyed watching Michelle over the years (how can you not enjoy that) but I'm glad she's upping her own technical ante with her new coach. If it works and she gets herself to a whole new level, that will be something to see. I love watching Sasha too, and hope she can get her mental game in order and also her scheduling plan in order. And I love others - Elena L, Arakawa, Fumie, etc.
I was glad to hear that Plushy got beat - not because I don't enjoy watching him skate, but he is incredibly talented and I think he can become even more exciting if he has a reason to push himself.
It's exciting to see the wonderful Chinese pairs challenging the Russian dominance. Now if the US and other countries could start producing some meaningful challengers....
I'm sad to say that ice dancing has sort of left me cold for the last several years. I think part of that was the excessively rediculous cr@ppy judging - rarely any placement surprises regardless of the performance on the day. I hope that will change with COP, but I'm still having trouble getting my interest level up.
Of course these are just my own opinions. LOL I almost cringe when I see the question "who is your fav" based on what I've seen in response to that elsewhere on the net.
Welcome doggygirl!! The only problem I have with this board is that there are not enough ice dancing fans on it.
However, COP has already proved to be very, very good for ice dancing. Teams are actually getting recognized for being better or worse in different parts of the competition. Placings change! You can't predict who will win anymore! It's wonderful.
There are still some things to be done getting the point system worked out, but so far, I am so thrilled with the excitement of ice dance this year.
Speak for yourself! I am so totally NOT sane!Originally posted by Dee4707
Let's just say that most of us are.


text:
Only a caregiver in charge of a loved one with Alzheimer's can know what it means to get some alone time. Just to steal a moment for a nap or for lunch with a friend is a precious commodity.
Thanks to a North Charleston church and a partnership with the folks from Respite Care, that opportunity is now available for people who live near Park Circle.
More than a year ago, Pastor Wendy Jacoby-Hudson felt her congregation at North Charleston United Methodist needed more ministry for older adults. One of her own congregants spoke of a lack of places in the North Area that helped with Alzheimer's patients.
Pastor Wendy started talking with Respite Care Director Laura Stefanelli.
Though there were three such locations in the county, there was nothing in North Charleston.
Three months ago, the newest location became the fellowship hall at North Charleston United Methodist.
Beatles and Benny Goodman
On Thursdays, a caregiver can bring a participant (they're not called patients) to the church where they can stay for almost four hours.
Trained volunteers then care for them in an activity-based program.
There's a social half-hour that involves coffee and pastries with discussion of current events.
Crafts also are introduced along with physical activity that might involve chair yoga.
There's lunch and often interaction with some of the children in the day school.
Recently, both the kids and their adopted grandparents made Christmas decorations together.
The participants at the moment range in age from 49 to 94. Music also is a constant. The selections range from The Beatles to Benny Goodman.
Pastor Wendy calls the program "fantastic." There was no push-back from the congregation and it's provided a chance for some younger retirees in her congregation to "give back."
One such volunteer, 89-year-old Stella McClintock, considers it the highlight of her week.
While this church does not average quite as many worshippers in its pews on Sunday as it once did, the church is obviously figuring out a path to offer assistance to a community that goes beyond the customary ways to praise.
The staff at Respite Care appreciates a church that's willing to open its doors to its community.
One ongoing frustration about Alzheimer's is that there's still no cure.
Both the church and the organization are joining hands to help people because they need some-thing now.
It appears all the parties in this endeavor are benefiting.
It's the caregiver, though, that probably appreciates this four-hour break each week the most.
Being in charge and responsible for a person with Alzheimer's is exhausting. The day seems to have no end.
The demands and needs of a loved one are constant and yet, there's a real possibility he or she won't even remember what happened just a day ago.
There's no price that can be attached to that four-hour break each week.
Even if the caregiver decides not to do anything during that down time, that, too, is a blessing.
If, in fact, it's more blessed to give than receive, it appears the folks at North Charleston United Methodist have figured out a way to do both.
Reach Warren Peper at 937-5577 or firstname.lastname@example.com.


text:
on March 4, 2013 - 10:53 PM
Honor Flight Buffalo has announced plans for two trips to Washington, D.C., this spring, as the nonprofit, all-volunteer organization begins its fourth year.
The one-day trips, scheduled for May 11 and June 15, allow veterans of World War II to visit memorials dedicated to their sacrifices.
Though offered to veterans free of charge, the trips cost $375 for each. Through the support of the Buffalo community, Honor Flight Buffalo has escorted 265 World War II veterans on 10 trips since its inception.
For more information, visit www.honorflightbuffalo.org.


text:
Top Definition
The growth of an inflammed, festered, and bloody hemorrhoid that creates a groove-like affect in your feces.
Dave, don't do it. Jeff has an ass knuckle, that's not going to be fun.
Sean Pinerによって 2006年09月30日(土)
Trending Now
Can you define these popular missing words?
Someone who is clueless or stupid.
"Dude the new guy is such a dumbass!
"for real, he's a total friggin' ass-knuckle!
"for real, he's a total friggin' ass-knuckle!
Skin boneによって 2011年05月21日(土)


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text:
Seneca County's October unemployment rate remained at 6.4 percent for the second month in a row, according to statistics released by the Ohio Department of Jobs and Family Services.
The county civilian labor force - the estimate of all people working or seeking work - grew from 28,200 to 28,400, and 100 more people are employed in October than in September, at 26,500. The number of people unemployed remained at 1,800.
The county's jobless rate and number of unemployed people in the last two months is the lowest since May 2008, which had a rate of 6.0 percent and 1,800 people jobless.
Article Photos
The state of Ohio's seasonally adjusted unemployment rate for October is 6.9 percent, which is down from 7.1 percent in September. Ohio's unemployment rate is a percentage point lower than the national average of 7.9 in October.
Four surrounding counties - Wood, Wyandot, Sandusky and Hancock - had lower rates in October than they did in September.
Three neighboring counties saw rates raise in October from September. Huron County had the most significant increase, with an unemployment rate of 9.8 percent, a 1.7 percent increase from September.
Crawford County's rate is up to 8.3 percent from 7.7 in September, and Ottawa County's rate is 7 percent, up 0.4 percent from September.
Nationally, in October unemployment rates increased 0.1 percent from September. The national rate has dropped 1 percent from October 2011 to October 2012.


text:
Tuesday, March 13, 2012
Sigh. Theres another item to cross off my bucket list, and not because I did it.
The Oak Room in New York Citys Algonquin Hotel has closed, which means Ill never have a drink at the home of the Round Table gang, a celebrated group of writers, critics, actors and wits.
Members included Dorothy What fresh hell is this? Parker, humorist Robert Benchley and authors Edna Ferber, Alexander Woollcott and Charlie MacArthur. (MacArthur co-wrote The Front Page, a hysterical play about the perils of print journalism that was made into a hysterical movie starring Jack Lemmon and Walter Matthau.)
The Round Tableor "The Vicious Circle," as they dubbed themselves--met for lunch each day from 1919 til 1929, drinking vodka gimlets and exchanging sophisticated wordplay and witticisms. Members became legendary for their sparkling wit. (My entire life Ive longed for someone to refer to my sparkling wit. Then I could die happy. And sparkling.)
The Oak Room became a nightclub in 1939, and launched the careers of many jazz and cabaret stars. Eventually, after years of declining attendance, the NYC landmark closed in January for renovations and will reopen as wait for it . a lounge for Marriott Reward Elite guests.
Ive been to New Yorkeven saw Bobby Short at The Carlylebut I always thought thered be another chance to bend an elbow in the Oak Room and eat sea bass at Tavern on the Green, but turns out I was wrong on both counts.
My life has been wonderfulIve had good health and great adventures, and made a living doing the only thing I ever wanted to do. But, being human, I want more. Dont we all?
Life is fleeting, my friends. I worry that Ill die or the European economy will collapse before I can fulfill my dream of eating Swiss chocolate in Switzerland.
So, no more putting off until tomorrow what I can, by hook or crook, get done today. Or next month. You know what I mean.
Im going to publish that book thats been languishing under a stack of files behind the church pew in the back bedroom, just as soon as I can claw my way to it. (Yes, its also on a flash drive, which lurks somewhere under the six-inch stacks of receipts, catalogues, bills, lottery tickets and old recipes that clutter the desk in front of the church pew. Pray for me, people.)
Im going to figure out Excel if it kills me. I may never need to used it, but I cant stand not knowing how it works.
Im going to skydive because it scares me senseless, and its time I jumped headfirst into something Im afraid of.
Im going to master a manual transmission. My dad tried to teach me to drive a Ford Falcon 35 years ago, one Sunday afternoon on our dirt road. Wouldnt you know there was a license check, and I ran over a Highway Patrol troopers foot. True story. My husband bought a little Geo Tracker two years ago for the express purpose of teaching me to drive a stick. After two lessons, I scared him so bad he sold it. Dont judge.
Im going to own a little burro, which I need as much as I need lice. Some women want diamonds. I want a donkey.
Im going to slurp pasta in Rome and buy chocolate in Switzerland. You can count on it.
Julie R. Smith, whos had learn Spanish on her bucket list for four years, can be reached at firstname.lastname@example.com.
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text:
on May 16, 2013 - 10:39 PM
LOCKPORT – Niagara County Judge Matthew J. Murphy III, frustrated by the failure of an expert to deliver a report that could be used in defense of a murder suspect, began setting deadlines Thursday.
But the result was a further two-month delay in the case.
Murphy ordered the attorney for John R. Freeman Jr., the alleged killer of 5-year-old Isabella M. Tennant, to deliver a Williamsville doctor's report to the prosecution by May 31.
The attorney, Robert Viola, has been saying since last October he intended to use a psychiatric defense for Freeman, 17, of Sixth Street, Niagara Falls.
He is accused of strangling the Cheektowaga child while he was baby-sitting her Aug. 26 in her great-grandparents' home on Sixth Street, and dumping her body in a stolen garbage tote.
A friend who allegedly helped him do so, Tyler S. Best, 18, of Barnard Street, Buffalo, is charged with tampering with physical evidence.
The pediatric neuropsychologist Viola hired examined Freeman in February, but no report has been submitted. Two weeks ago, Viola asked for more time, but Thursday, he still had no report.
"I am extremely frustrated," Murphy said. "I have to set deadlines to move this case along."
After the May 31 defense doctor's report, the prosecution will have six weeks to have its own expert interview Freeman. That report must be submitted by July 12, Murphy ordered. The sides will return to court July 26.
On that day, Best's attorney, James J. Faso Jr., will argue his request to have the two defendants tried separately. At present, they are to be tried together starting Aug. 19.
If the cases are severed, "Our intention absolutely is to try Mr. Freeman first," Deputy District Attorney Holly E. Sloma said.
In other cases Thursday in County Court:
• Lockport attorney David C. Douglas accepted a court assignment to defend David L. Alfonso, 28, the Lockport resident charged with attempted murder in a Dec. 31 attack on his girlfriend's 7-year-old daughter. The Public Defender's Office had to drop the case after learning that it had once defended a person who will be a prosecution witness against Alfonso. County Judge Sara Sheldon Farkas set a June 13 pretrial conference and a July 29 trial date.
• Also receiving a new attorney will be Jennifer R. Marchant, 23, of North Tonawanda, who stabbed her live-in boyfriend to death Feb. 6. Her previous attorneys, Glenn Pincus and Steven M. Cohen, argued that Marchant killed Ralph D. Stone Jr., 24, in self-defense. However, a grand jury charged Marchant with first-degree manslaughter. However, it appeared Thursday that Marchant's family is financially overextended. Pincus said her parents and grandparents "are not in a position to assist her any further."
Farkas ordered Marchant, who is free on $100,000 bail, to apply to the Public Defender's Office and return to court Wednesday with a new lawyer.
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