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NSCLC is "Major Battlefield" as Merck,...
As Immunotherapy Revolutionizes the Cancer Treatment...
LC-MS Gains Favor Due To the...
Wall Street Decline Takes Its Toll...
Tag-lite is a cellular screening platform from Cisbio Bioassays that enables the investigation of natural ligand, small molecule, or antibody binding to cell-surface proteins such as GPCRs and RTKs. This technology, which combines HTRF and SNAP-tag technologies, can be applied to the discovery and development of therapeutic antibodies against cell-surface proteins.
Tag-lite's high-throughput format is ideal for primary and secondary screening of antibodies and can be applied to a variety of assay formats for pharmacological characterization.
Tag-lite was investigated to screen therapeutic antibodies for their binding to cell-surface protein targets and characterize their affinities. Different assay formats were applied to determine the binding of antibodies to two different receptors: CXCR4, a GPCR belonging to the chemokine family, and EGFR, a tyrosine kinase receptor.
Binding of the antibodies to their targets was detected using Tag-lite. Specific cell lines were designed for each receptor, allowing either binding experiments, functional assays (cAMP, Phospho-Erk) or internalization assays.
Tag-lite starts with the cloning of the gene encoding the receptor of interest in a plasmid containing the SNAP-tag sequence. This SNAP-receptor plasmid is then transfected into HEK cells to produce Tag-lite cells. These cells can be used to investigate the activity of the receptor via functional tests or can be specifically labeled on the SNAP-tag using SNAP-Lumi4 Tb substrate. The labeled cells are then used for different applications, like ligand-binding assays, dimerization, and internalization (Figure 1).
To detect the binding of antibodies on cell-surface receptor targets, different assay formats were designed. Antibodies were screened by displacing different types of ligands—a labeled natural ligand or a labeled antibody—away from the receptor of interest. In this case, antibodies were detected by their binding to the ligand site. Antimouse Fc-d2 labeled antibody was also used to detect the binding in an indirect assay format (Figure 2).
Reagents: SNAP-Lumi4-Tb, antimouse Fc-d2, SNAP-CXCR4, and SNAP-EGFR plasmids and the labeling medium were from Cisbio Bioassays. Lipofectamin 2000 was purchased from Invitrogen, and the cell-dissociation buffer was from Sigma Aldrich. Anti-CXCR4 antibodies (12G5 and 44717) and anti-CXCR7 antibody (11G8) were from R&D Systems.
Covalent labeling of SNAP-receptor cells: A solution of Tag-lite SNAP-Lumi4-Tb substrate at 100 nM was prepared in Tag-lite labeling medium. After aspiration of the cell culture medium, 3 mL of this solution was added to the cells expressing the SNAP-receptor in the T175 flask, followed by a one hour incubation at 37ºC. The cells were then washed four times to remove the excess of SNAP-Lumi4-Tb and detached using the cell dissociation buffer. The cells were frozen under 1 million cells/vial in culture medium and 10% DMSO.
Ligand binding assay: The SNAP-Lumi4-Tb labeled cells were thawed and washed with PBS, then resuspended in labeling buffer. Binding assays were performed in a total volume of 20 µL in 384-small volume white plates. 10,000 cells/well were incubated for one hour at room temperature with different concentrations (0–200 nM) of labeled ligand (SDF1-red, mAb anti-CXCR4-red) or unlabeled ligand (mAbs anti-CXCR4). 100 nM of antimouse Fc-d2 was added for the detection of unlabeled mAbs.
Competition binding assay: Competition binding assays were carried out in a final volume of 20 µL in 384-small volume white plates. 10,000 labeled cells were incubated with red-labeled SDF1 or red-labeled EGF (final concentration of 12.5 nM or 10 nM respectively) in the presence of different concentrations of antibodies (0–100 nM). Following incubation, the plates were measured on a TR-FRET reader.
cAMP functional assay with cAMP dynamic 2 kit: The functional tests were performed in 20 µL final volume in a 384-small volume plate. 10,000 cells were incubated with Forskolin (2 µM final concentration) and different concentrations of SDF1 or 12G5 antibody (0–1 µM final concentration). The plates were incubated 30 minutes at room temperature before being read on a TR-FRET reader.
Internalization Assay: Internalization assays were carried out in a final volume of 20 µL in 384-small volume white plates. 10,000 labeled cells were incubated at room temperature with a high concentration of internalization reagent in the presence or not of different concentrations of SDF1. The plate was measured after a two-hour incubation.
Jean-Luc Tardieu, Ph.D. ([email protected]), is product manager at Cisbio Bioassays. SNAP-tag is a trademark of New England Biolabs.
Jean-Luc Tardieu, Ph.D. ([email protected]), is product manager at Cisbio Bioassays. SNAP-tag is a trademark of New England Biolabs.
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Top Definition
the angry mailman is when a girl is having hardcore anal sex with a male and suddenly gets off his dick and farts in his face. Some peices of poop may come out because of how loose her anus is. This action causes the male to get really angry and mad and chase her around like a dog would chase a mailman.
My girl gave me the angry mailman last night and now I think I have pinkeye. What a bitch
dari DanaNicoleVanWeenan Minggu, 04 Juli 2010
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subset: commoncrawl


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The USS Maine explodes mysteriously in Havana Harbor, the teddy bear is born, President Franklin D. Roosevelt survives an assassination attempt, and Jeffrey Dahmer is found guilty, all on this day.
Full CoverageBreaking News
On this day: February 15UPDATED 1:00 AM CST Feb 15, 2016
CommentsThe views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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We don't have canned pumpkin in Australia either. But the book somewhere says how long to strain cooked pumpkin to get the same density/thickness. I wonder if sweet potato/kumara could be used. It tends to be a bit drier than pumpkin and you probably wouldn't need the coconut flour. Just thinking.
I've bought Practical Paleo as an e-book but have just bought the hard copy as I want to be able to hold it in my hands. There are many great recipes in it that I want to try. I've already made a couple and they went down well.


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Decks and Patios Ideas, Pictures and Estimates
Decks are an important, and often overlooked, element to any home. A nice deck is a place to read a morning paper, sip lemonade on a weekend afternoon, or throw a couple of steaks on the BBQ for an evening get-together. In today's busy world, nothing is more important than creating outdoor spaces for relaxing and entertaining. This shift reflects a lifestyle–outdoor living–that extends beyond a home's traditional walls.
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Full CoverageBreaking News
F. Lee Bailey: Albert DeSalvo was Boston StranglerUPDATED 9:44 AM EDT Jul 12, 2013
F. Lee Bailey, the lawyer for the longtime suspect in the 1960s slayings attributed to the Boston Strangler, says new DNA evidence should end speculation about the killer's identity.
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The flaikTM GPS offers real-time tracking of the wearer and lets you know precisely where your kid is on the mountain. Skiers and snowboarders can access their daily statistics on Internet. Complimentary for kids 12 years old and under in most programs and lessons with Tremblant Snow School. The lightweight hard cased GPS is attached with a band above the ski boot.
Share your results on your favourite Social Media Networks like Twitter, Facebook, Youtube, MySpace, etc.


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Top Definition
On the next train outta here, takin' the next bus out!
On reality show Flavor of Love 2... Young Buck of G-Unit fame said, "She is just taking up space. She needs to be on the next thing smokin', she aint got no business around a playa man!" When asked if Flav should keep a plus sized woman in the house.
av Brenda Valenz 10 september 2006
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Top quality progressive house track available in 2 versions: extened mix and short mix. 8:22 and 5:46 -This uplifting and powerful progressive house royalty free track is perfect for your modern groovy projects, and can give the right beat to your movie!
2 Versions Included! 8:22 and 5:46
A strong kick and bass line make the music really intense, and the housy hats and percussions gives to this track a groovy mood.
A super-pumped melody made by 4 synths guarantees the best appeal on every target, also to the club addicted!


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Lifestyle Mag is an online magazine oriented HTML website that also fits perfectly as a news, fashion or even a celebrity & gossip blog. Colorful and fresh, it should be right at home with modern trends and healthy culture. The addition of sliders and page styles makes Lifestyle Mag very versatile and easy to use.
IMPORTANT: Support is offered exclusively in our Help Desk not here in the comments section. You'll need an account on our website in order to be able to submit a ticket. Please include the ThemeForest Item Purchase Code – Learn how to find it
Key features:
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The package contains:
- 13 Valid XHTML files (for both light and dark variations)
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Useless Laws
What good are laws without enforcement?
April 21, 2013
Mingo County, W.Va., Sheriff Eugene Crum might be alive today if an existing federal gun control law had worked as it was supposed to. That revelation came on the very day U.S. Sen. Joe Manchin, D-W....
"It doesnt take more resources to arrest someone."
So I guess we are now arresting people on the honor system? "Hey, you know you broke the law, so come on down to the station or barracks and turn yourself in".
Purely ludicrous, investigations take resources, arrests take resources, documentation takes resources, and prosecutions take resources. Agencies, including law enforcement, have had their legs knocked right out from underneath of them, and the uber-con dream of neutering the government into irrelevance is becoming a reality; they are strangling it with its own umbilical, funding. If Congress is going to pass laws, then they are responsible for making sure the agencies have the funding to enforce them, the problem is that a very vocal minority doesn't want the government to succeed in that aspect.
0 Agrees | 3 Disagrees | Report Abuse »
Yep pass more gun laws it really works in Chicago and liberal states. Hundreds of kids being murdered in Chicago every year.
3 Agrees | 1 Disagrees | Report Abuse »
The R's have absolutely refused to even CONSIDER any nominee to head the ATF. With no head, agencies will not work. So why hasn't the JOURNAL called for a Director to be approved any time in the last 5 years???
Sorry, but these are crocodile tears for the deceased sheriff, and a mask for the Journal's determination to eviscerate any gun laws so that more sheriffs and police and schoolchildren can die at the hands of madmen and criminals.
Maybe the Journal could advocate removing the silly requirement that Congress approve the ATF director. It's not a cabinet position.
Really a disgusting editorial.
2 Agrees | 3 Disagrees | Report Abuse »
0 Agrees | 0 Disagrees | Report Abuse »
P.S. -- Apparently, when Eric Holder was working in the Clinton administration, he helped convicted terrorists apply for clemency, which Clinton of course signed, and got the terrorists out of jail. Fast forward to this week, and guess who is in charge of prosecuting the newest terrorist? Eric Holder.
5 Agrees | 2 Disagrees | Report Abuse »
Eric Holder has provided more assault weapons to dangerous, violent criminals, than the NRA has.
6 Agrees | 2 Disagrees | Report Abuse »
So rev should we prosecute and enforce murder laws or someone taking his AR-15 to the gun range to do target practice, or both. Liberal sure bring a smile to my face. If they weren't so serious I'd think this was the comedy channel.
3 Agrees | 2 Disagrees | Report Abuse »
"Don't, why don't you take your sarcasm to Newtown and see how it works."
It's not sarcasm, it's reality. I know liberals have a hard time using logic sometimes, but I can understand that when liberals think with their heart and not their head. So tell me again exactly how any of these proposed laws would have stopped any of these shootings? There are over 300 million guns in the U.S. so how exactly do you propose we will keep them out of criminal hands banning an all out ban?
3 Agrees | 4 Disagrees | Report Abuse »
Don't, why don't you take your sarcasm to Newtown and see how it works.
3 Agrees | 3 Disagrees | Report Abuse »
Just one more law that's all we need, OE more law would solve all the homicide issues we have here. Oh yea and let's ban pressure cookers while we're at it, or at least require a backgroung check to buy cookware.
3 Agrees | 6 Disagrees | Report Abuse »
Repubs and the NRA have worked for years to weaken the ATF. It has fewer investigators than in 1973, fewer agents than the Phoenix Police department, hasn't had a permenant director in six years, and its budget has been static for decades.
6 Agrees | 5 Disagrees | Report Abuse »
"15,000 Felons & Fugitives Tried To Buy Guns Illegally Last Year, Obama Adm. Prosecuted ONLY 44" If you want these laws enforced you have to provide the resources. You cannot keep cutting then complain because things do not get done.
7 Agrees | 4 Disagrees | Report Abuse »
""ATF has been without a permanent director for six years." Obama's nominee awaiting Senate confirmation. It is hard to run an agency without a head. Another case of Repubs proving that government doesn't work by denying resources.
8 Agrees | 4 Disagrees | Report Abuse »
Showing 13 of 13 comments


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NSCLC is "Major Battlefield" as Merck,...
LC-MS Gains Favor Due To the...
Developers of DTC Genetic Testing Are...
As Immunotherapy Revolutionizes the Cancer Treatment...
Everything in chromatography is a compromise. It's like a game, trying to come up with the best system of compromises that gives you the optimum platform for the separation process.
"There are lots of ways you can do it," explains Jack (J.J.) Kirkland, Ph.D., vp for R&D at Advanced Materials Technology (AMT), who will be among those speaking at CASSS' "HPLC" conference later this month. "What you try to do is balance all the parameters that are involved and try to come up with the best thing you can."
The theory suggesting that smaller particles in an HPLC column increase the ability to separate components goes back at least to the early 1960s, recalls Dr. Kirkland.
Another critical parameter is that "you want enough surface area so you can load a sample that you need, and particles creating the required surface area to give you the kind of retention that you need." By the early 1970s, both of these needs were addressed with small—5–7 µm—totally porous particles. Pores wending through the particles increased the surface area.
But the further a molecule has to diffuse into the totally porous shell, the more time it takes. "More time for diffusion means a broader band, and that means less column efficiency," he notes. This is especially important for larger molecules such as peptides and proteins for which diffusion can be rate-limiting for separation speed.
But what if you could make smaller particles—say, 2.7 µm—with pores that don't go all the way through, so that the diffusion path is much shorter? Such superficially porous particles (SPPs)—which AMT introduced in 2006—allow "you to run faster mobile phases, increase the efficiency of the system, and reduce the separation time," Dr. Kirkland says. They have an efficiency equivalent to totally porous particles of 1.8 µm.
The reduction of surface area means that the amount of sample that can be loaded onto SPPs is less than what totally porous particles can handle. But Dr. Kirkland notes that because mass spectrometry (MS)—which many people are doing—doesn't require a lot of sample, this isn't a big problem.
AMT recently introduced 2.7 µm SPPs with wider pores to insure unhindered access of larger solutes to the porous shell for rapid, efficient separations. Because the pressure required to drive the mobile phase through the column goes up with the square of the particle size, 2.7 µm is about as small as particles can be and still run on conventional HPLC equipment—sub-2 µm particles require expensive, specialized high-pressure (UHPLC or UPLC) equipment with optimum separation speed, he points out.
While such an apparatus is now in wide use, it's "still beneficial to the people who use the columns day in and day out to operate at lower back pressure," says William Barber, Ph.D., Agilent Technologies' R&D manager for liquid chromatography columns. There is less stress on the instrument and the column, therefore extending the interval between maintenance of the instrument and lengthening the effective lifetime of the column.
Agilent has for years offered larger particles (e.g., 3.5 µm and 5 µm) with a 300 Å pore size, designed for biochromatography on standard HPLC columns and recently commercialized a 1.8 µm line of 300 Å pore size columns for use with UHPLC.
About eight years ago Agilent tested the effect of broadening the particle size distribution on the permeability and efficiency of its small molecule (80–120 Å pore size) UHPLC columns. Its manufacturing process generates both spheres (unimers) and also a small percentage of fused particles (dimers), with the vast majority of dimers removed prior to packing the columns to market.
Dr. Barber is currently conducting similar experiments on the 300 Å pore particles. "We systematically add dimers back in known quantities, to more systematically study what our process would look like if we left a certain amount in or varied the amount of dimers that were left in the product."
The results for the large molecule columns are similar to those seen for the small molecule columns. "We still see the same trend where you can add some of these dimers back and it really doesn't have any effect on the efficiency up to about 10–20% of the dimers," Dr. Barber says. "But you do tend to see a consistent change in permeability or back pressure right from the beginning, as soon as you start adding dimer."
"We haven't done all the measurements yet," so the results are still preliminary, Dr. Barber points out. For example, they still want to do van Deemter plots on all the materials to see how the performance versus flow characteristics change with the different mixtures; to test different size molecules to determine whether molecular weight plays a role; and to query different modes of chromatography.
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CALCUTTA - One small step could turn into a giant leap for the Beavers.
After an 0-21 season, Beaver Local broke a 24-game losing streak last year and went on to win seven games. Now, the Beavers are hoping to turn the corner for good.
"As a program, it definitely lifted things up," Beaver Local coach Jake Walgate said. "I think if we had a few breaks here and there, it could have been even better. We got after it every game and competed every game. Now, I think teams will look on their schedule, see Beaver Local and know they're in for a tough night."
Article Photos
Despite the team's increased success last season, Walgate said neither him nor his team are resting on their laurels.
"The guys can definitely see the progress they've made," he said. "But, we're not satisfied with where we are. We don't want to take a step back so we're going to keep pushing forward every day."
A group of six seniors last season were a big reason why the Beavers were much improved.
Gone to graduation are Ryan Smith (12.6 ppg), Nick Miller (7.6), Kevin Sevey (6.1), Cody Dawson (4.3), Cody Reese (3.7) and Jake Allen (2.7).
With those losses, the Beavers will likely rely heavily on senior Troy Hudson this year.
Hudson ranks third among returning leading scorers in the area after averaging 15.4 points per game last season. Hudson was a model of consistency, scoring double digits in 18 of the Beavers' 21 games.
"He's been our scorer the last two years," Walgate said of Hudson.
"We're going to need him to score, but also to trust his teammates. Defenses will key on him. He's still got to get his shots, but also be able to provide opportunities for others."
Over the past three seasons, the Beavers have turned to Miller to distribute the basketball as the starting point guard. With Miller's exit, in steps sophomore Chase Hilliard to run the show.
"Nick did a wonderful job from a young age for us," Walgate said. "We're hoping Chase is setting up for the same role. But, he'll have some guys beside him this season to help him out."
Senior Zack Mick, who averaged 5.2 points per game last season, appears poised to take over some of the scoring for the Beavers.
Rounding out the starting lineup with Hudson, Hilliard and Mick will likely be seniors Brandon Fetty and Matt Chamberlain. Also in the mix are Ethan Campbell, Josh Underwood, Chandler Cornell and Trevel Thompkins.
One area of concern for Walgate is his team's lack of size.
"Since I've been there, height has always been a problem," Walgate said. "We've got a couple of guys maybe 6-foot-2, but we'll have to get after it on the boards to make up for it."
Walgate said his team's unselfish nature coupled with its athleticism and quickness should be able to compensate for what the Beavers lack in post play.
If Beaver Local is to take the next step as a program, the road won't be an easy one. The Beavers will compete in the All-American Conference again this season before becoming an independent.
"We're definitely not satisfied," Walgate said. "Did we give everything we had every night? Yes, but we had some mistakes that were preventable. I think we lost eight to 10 games by 10 points or less. We've got to control the game at the end.
"We've been talking as a team about finishing games. We let some close games get away from us. It comes down to execution."


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The sporty type who loves Nutella!
Hey, there's Keith!
door rheaivykit 25 april 2013
Trending Now
Can you define these popular missing words?
Top Definition
a sweet ass muther trucker lookin for a good time that is not afraid of anything. origin: 15th century Scotland
That dude is a huge keith.
door barneye 8 december 2007
is some one who is smart sexy strong fast a ladys man and overall good at everything he tries.
wow that guy is such a keith i wanna do him so bad.
door initial k 6 september 2008
Shy simple quiet type. That sits back and watches. Has a heart of gold and will give you peace and love. He watches over you without you even knowing. His tender touch and beautiful eyes will cause your heart to skip a beat.
Oh my, see that guy in the corner, he is such a Keith.
door simplethoughts 3 februari 2010
is someone who is strong, sexy, a flirt, super fly, and hella smart. is to be known that he has a big thing. is someone famous and gets all the ladies because he's a ladies man
Man i wish i was a keith!
Everybody wants to be a keith!
Everybody wants to be a keith!
door critinkywinky321 18 januari 2009
A really fat joint. Not to be confused with a blunt. A Keith is a joint that is about to bust out of the papers.
"Hey don't Bogart my Keith."
door Keifermail 12 juli 2009
A gorgeous man you are in love with who flirts with you consistently, in a misleading way, but refers to you as a sister/member of the family.
Keith: you are such a wonderful woman, you came into my life at such an important time, you are the best little sister, I love you.
Woman: (fuck) I love you too...
Woman: (fuck) I love you too...
door Barbra Anne 20 maart 2008
Keith is the kind of guy who is extremely goofy and rarely serious. He can be a complete asshole, but you can't help but love him. He also complains a lot about the most random things and can make others feel uncomfortable because he's a very bold opinionated person. He's socially awkward around people he's not used to seeing, but once you get to know him, you'll see how crazy he really is.
I met Keith a few months ago and he used to be weird to be around, but now he's a silly fun guy to chill with
door bgfddtsfs 7 september 2012


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ManiacStanMember Since 03 Mar 2004
Offline Last Active Oct 20 2007 12:16 PM
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- Active Posts 447
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- Member Title You gonna make biscuits?!
- Age 30 years old
- Birthday October 11, 1985
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Aurora, Ontario, Canada
The Wings! Umm, Punk and Rock music, video games (Mostly NHL 06). I'm a comedian. I love to read and write comedy. I love Kevin Smith movies, he is my idol. South Park is my favorite show on earth. It rules over me. And Don Hertzfeldt rules. Hmmm... And that's about it.
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text:
San Bernardino Valley High School Students Place in Top 20 Percent Nationally for Second Consecutive Year
SCE Federal Credit Union Helps Teens Secure Top Finishes in 2012 National Financial Capability ChallengeMay 17, 2012 | News & Press
Contact: PCGCampbell Eric Garner 310.224.4957
IRWINDALE, Calif. (May 17, 2012) – When SCE FCU financial instructors talk to Colony High School's business classes about financial literacy, the students cash in.
The San Bernardino County school had five students finish in the top 20 percent and one above the 90th percentile nationally during the month-long web-based National Financial Capability Challenge (NFCC) designed by the US Dept. of Treasury and the US Dept. of Education to teach high school students the X's and O's of personal finance.
Currently, California is one of 46 states that do not require students to take a financial literacy course in order to graduate. In the 2012 NFCC, California's average student score was a 67.09 percent, ranking it 44 out of the 50 states.
Colony High School, however, does offer financial literacy training with the help of the SCE FCU Foundation.
"The combination of book knowledge, real-life scenarios and having people from industry work with them, like SCE Federal Credit Union, makes all the difference for these kids," said Kevin Davis, Colony High School business teacher. "It's my opinion that by teaching our youth the ins and outs of personal finance, we prepare them for life. We continue to make it our goal to give students applicable, working knowledge that they can apply in current and future financial situations. SCE Federal Credit Union has been an integral part of that."
SCE FCU has been supporting residents in the San Bernardino Valley for 60 years and partnering with local schools for the past decade. Their credit union foundation will conduct more than 100 financial literacy workshops and courses throughout 2012.
"Our foundation was created primarily to help young people gain financial insight and moxie for facing the real world," said Dennis Huber, SCE FCU CEO. When local kids secure top 20 percent finishes, it's validation we're getting through to them. Congratulations to the students for their outstanding efforts."
SCE Federal Credit Union was founded in 1952 and currently has nearly 50,000 members, $560 million in assets, several Southern California and Nevada branch locations, thousands of shared branch locations across the United States and more than 28,000 surcharge-free ATMs available to members. SCE FCU serves all of Southern California and Southern Nevada, with membership open to individuals and businesses. SCE FCU is a not-for-profit entity committed to improving the financial well-being of the communities it serves, especially those underserved by mainstream financial institutions. With a strong commitment to volunteerism, employees donate hundreds of hours to local community causes each year. Additionally, the creation of the SCE FCU Foundation provides much-needed financial education to the underserved in Nevada and Southern California.
San Bernardino Valley High School Students Place in Top 20 Percent Nationally for Second Consecutive Year (PDF)


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Top Definition
Combining the actions of - whether intentionally or not - opening the eyes as wide as one can, whilst displaying a large, open smile, showing as many teeth as possible. It is meant to be embarrassing - whether for the person caught with the Blaise face, or the person the Blaise face is directed to.
Often used as an expletive when displaying
the expression.
Often used as an expletive when displaying
the expression.
Wow, I totally had a Blaise face in this picture.
Blaise face!
Blaise face!
po dshot123 Фабруар 12, 2009
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Are unused or expired prescription medications clogging up your medicine cabinet?
Clear out the clutter of pills Saturday from 10 a.m. to 2 p.m., when the Drug Enforcement Administration is scheduled to stage a National Prescription Drug Take-Back Day. This is an environmentally responsible means for those who missed previous events - or who have subsequently accumulated unwanted, unused prescription drugs - to safely dispose of those medications.
In the five previous Take-Back events, the DEA, in conjunction with county, state and tribal law enforcement partners, have collected more than 2 million pounds (1,018 tons) of prescription medications.
To further the effort this year, a mobile command unit will be erected in the parking lot across from the Wees Annex of the Randolph County Courthouse on Randolph Avenue in Elkins on Saturday, Randolph County Sheriff Mark Brady said.
"The Randolph County Sheriff's Office encourages all residents to look in their medicine cabinets and look around their homes and bring those medications to the drug take-back center in Randolph County," Brady said Wednesday.
Doing so eliminates the possibility of prescription drugs winding up in the hands of children or minors, the sheriff said - not to mention the fact that outdated medications may no longer be safe for ingestion.
Fact Box
Drug Take-Back Day
10 a.m. to 2 p.m. Saturday
n Health Center Pharmacy
909 Gorman Ave.
n Parking lot across from the Wees Annex
Randolph Avenue
Mill Creek
n Tygart Valley Pharmacy
46 Town Center Plaza
n Community Care Center
149 Ivy Lane
n Mace's Pharmacy
204 Crim Ave.
n Mace's Pharmacy
303 S. Main St.
"The sheriff's office has always cooperated in this event to help the citizens of Randolph County dispose of any prescription drugs that are not being used to get them out of home and off the streets, where they may be misused by others," Brady said.
Amanda Smith, pharmacy director of Davis Health System, agreed that prescription drug collection is an important service.
"Safety is a big issue associated with the take-back event," Smith said. "If you have unused medicines in your home, and others around you know, it makes for a potentially unsafe situation. Someone could break into your home to take those medicines. Also, old and expired medicines could be used by other family members they were not intended for. That person could be allergic to the medicine, or it may have adverse effects with other medicines they take."
Smith said the environment is another consideration with these medicines.
"The old recommendation was that old or expired medicines be flushed down the toilet or down the sink," Smith said. "The DEA has completely taken that recommendation back. We do not want to further pollute our water ways and fish. That's why consumers have the opportunity to bring these drugs back for safe and environmentally friendly disposal during take-back days."


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5 Things You Learn From a Lifetime of Screwing Up
We have offered you a wealth of valuable and insightful advice over the years, to the extent that you may have come to think of us like some sort of profane Old World grandmother -- as caring and wise as we are caustic and chock-full of synonyms for "penis." But perhaps you feel that all that well-intentioned advice doesn't apply to you, not because you're a well-balanced human being -- God knows nobody is mistaking you for one of those mythical beasts -- but because you are now and plan to continue being a gargantuan fuckup for the foreseeable future.
"No, I'm drunk and high: It's called multitasking!"
Nobody's judging you! I myself have been a semi-professional fuckup for the bulk of my life, and I regret nothing (if only because I don't remember most of it). In fact, I'm of the opinion that our lives would be downright boring without the occasional barrage of hilarious mistakes and ill-informed decisions. So here are a few pieces of advice solely for my fellow fuckups. I offer it not to help you be a better person, but to help you be a safer, more efficient, and beyond all, more hilarious fucker of ups.
#5. On the Subject of Hallucinogens
Do 'em.
Don't get me wrong: If you don't do drugs, I am not advocating that you start. I'm just saying that, if you are already setting out on a lucrative career of Laughing at Infomercials at Three in the Morning, please at least consider minoring in the promising field of Hallucinogenic Hilarity. Because if you're experimenting with narcotics now, odds are you're going to move on to something harder at some point -- if only to try it. And if it's a toss-up between stuff like coke and heroin or a bag of mushrooms, you grab that bag and run like you're a tiny Italian man in need of extra lives.
"A-ha! I can'a see through time'a!"
Here's a good rule of thumb: Do about half as much as your friends tell you to.
They will tell you to "eat the whole thing" of whatever they give you, regardless of the size of said "thing" or the strength of its contents. That's because stoners operate on a binary system of measurement: Something is either cashed or there's "a whole thing of it." If you're worried about your impending levels of inebriation, just take a little at first and squirrel some away for later. Also, if you can at all help it: Do not do hallucinogens in the city.
Right angles are the wrong angles. I know you don't think that geometry can bum you out, but just the simple act of being around man-made structures can ruin a good trip. Out in the woods, you might operate under the delusion that you've become a Gummi Bear, and you will definitely meet some kind of spirit wolf; in the city, some dude might lick your elbow on the subway, and you will definitely see somebody get hit by a car. It's a whole different, and generally much worse, experience.
"Whoa, trippy! This guy says he needs money to pay for insulin ... this is the worst high ever."
Another good rule of thumb: Make absolutely sure you're not driving anywhere on hallucinogens. Don't just assume you'll know better. You cannot trust your high self; that bastard has no idea what he's doing. You need to stay one step ahead of him. So take your keys out now and set them in the paws of an old dirty teddy bear with one eye missing. I know that doesn't make any sense to Sober You, but trust me: Stoned You will not cross the bear.
#4. Buy a Bitchin' Car
Or truck, or motorcycle, or whatever your heart desires. As long as you can picture Burt Reynolds or Steve McQueen jumping that bitch over a river, you buy that sucker. No, it is not a practical conveyance. There is no justifying having any kind of awesome vehicle in your young adult life. Conventional reason says that you should buy something reliable that gets good gas mileage, because you don't have money for repairs or the tiny war crimes that gas prices have become. And besides, if you can afford any kind of bitchin' transport as a young adult, it's probably beat to shit and only technically street legal if you file it with the DMV as "Farm Equipment: Tractors and Misc."
But that's OK, because you know what's cooler than a cool car? Telling everybody you're working on a cool car.
You know what they say: A Camaro in the garage is worth 10 Fiestas on the road.
Or at least they would say that, if they had a bitchin' Camaro.
Pappa John's via Autoblog
"I used to worry about stuff like insurance and gas mileage -- now I only worry about drowning in pussy! No seriously, I'm so scared. Somebody help me."
This is the only time in your life when routine car troubles are still a reasonable excuse. Once you're a for-realsies adult, God forbid that ever happens, they expect you to plan far enough ahead to compensate for any recurring vehicular mishaps. You're also probably young enough that you still have carless friends whom you can merrily squeeze for double the amount of gas money that ferrying them around costs you. Get high with Paco and Bill and take 'em to Taco Bell, then ask them both to pay for gas: Each is too ripped to realize the other has already paid. Boom! You just made $10 for a $2 trip.
You know what that's called? That's called profit. This rusty Camaro is technically a business! You could probably write this shit off on your taxes, if you made enough to pay them, or cared enough to do them (which you absolutely don't).
#3. Put Your Dick in Crazy
Everybody will tell you not to, and technically, they're right: Don't trust your heart to people with emotional problems, because they don't have the ability to properly care for it. Don't enter into any commitment, implied or otherwise, with a mentally unbalanced person, because you don't know what they'll do if they ever feel slighted by you.
These are all very true and entirely reasonable pieces of advice. They're just omitting one incredibly important detail: Psychopaths are amazing in bed.
"Sure, I'll probably punch your mother one day, but I'll do that thing you like in bed that everybody else thinks is gross!"
Oh yes, they will absolutely make your domestic life hell. You'll long for the days when you didn't wake up with the word "BETRAYER" smeared in poop on the hood of your Camaro -- but everybody needs to have sex with a psychopath at least once, if only to set a point of reference for exactly how much shit you're willing to deal with for the promise of exotic intercourse. Oh, and ladies, this applies to you as well: "Put your dick in crazy" is just a saying, probably because "Let crazy put its dick in you" sounds a lot worse.
Here's a good rule of thumb: If somebody's not yelling at you by the time you're done bonin' - your partner, your parents, the neighbors, the National Guard - then you have not yet begun to bone.


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INCLINE VILLAGE, Nev. - Mark your calendars for the March 14 WCSD community meeting regarding future plans for Incline Village public schools. The new superintendents spent the fall assessing local education needs and opportunities through discussions with administrators, teachers, students, and community members.
Now they seek our input on a proposed multi-year strategy for improving education quality and performance for all students and schools. As Superintendent Martinez said months ago, he would like to see our schools become the flagship K-12 system in the district.
Though I haven't been privy to details of the proposed plan, I'm encouraged by hints that JoEtta Gonzales shared at the last Incline Great Schools Advisory Committee meeting: to build upon the "vertical alignment" initiatives that IGSAC has been working on since 2010 and to more fully leverage Incline's unique educational and community offerings to empower our diverse student population to greater heights of achievement.
Of course the devil is in the details so the ensuing discussion should prove to be very informative.
As discussed previously, more rigorous curriculum standards are barreling upon all schools like a tsunami even as WCSD faces another $40 million shortfall this year. After several years of shrinking budgets and growing class sizes, teachers struggle to maintain and raise student proficiency levels and growth rates - which correlate with graduation rates.
With literally no capital budget, facilities show their age and outdated computers sit in labs. Yet teachers are heroically expected to nurture each unique student into deeper learning at a faster pace and in ways that build necessary skills for success in today's technology-based jobs and careers.
Ideally all students should graduate with a passion for life-long learning and capacities to solve complex problems and innovatively build a brighter future. However, top educators know that achieving such outcomes cannot be done with the same old approaches. Education excellence today requires a transformation in how learning - and teaching - happens.
For a good idea of what the future of learning and schools looks like, watch the TED video by Sugata Mitra, who won the TED Prize 2013, "Ted Talk by Sugata Mitra," via the Huffington Post at the following link: http://huff.to/Xp6zMC
Mr. Mitra builds upon the inspirational insights of Sir Ken Robinson (my education guru) to elucidate how learning optimally happens. Aristotle and Socrates first modeled this by posing compelling, universal questions and letting students go on intellectual adventures with each other to answer them. Instead of lectures, students self-organize using their creativity, critical thinking, and communication skills to journey through physical and virtual experimentation - learning most vividly from failures.
Teacher-coaches in the digital knowledge age mainly ensure students have essential learning tools - including Internet access, engaging challenges, and peers to learn with - then nurture and celebrate their successes.
As the Incline Schools Data Summit Report made clear to me, reversing concerning data trends will require more than just teachers and students working harder - they are already stretched thin! It means working smarter. How? Ensuring that every student has access to the world of knowledge (computer and connection) with rich opportunities to ask and answer compelling questions and solve real-world problems both alone and in groups - whether at school, home, a friend's house, a local college, a local business, a non-profit, or in other cities and countries.
Moreover, each student should be encouraged to go deep into their passions and develop their singular aptitudes to their highest potential. Their individual learning pathways should adapt and evolve as they do. The age of factory-style education is extinct. Welcome to "just in time" adaptive, individuated learning!
I am confident that this community has a unique, untapped potential to manifest such a vision here and now - in partnership with WCSD. Can we collaborate around a strategy to manifest an enlightened center of learning that offers all of this for each and every student? Can we create a center of learning that magnetically attracts students and families with the highest expectations for educational excellence?
First step to a potential answer: Join the WCSD community meeting March 14, 4-6 p.m. in the IHS cafeteria.
- Mary Alber is an Incline Village resident with two children in local schools and an advocate for 21st century learning opportunities. She holds a PhD in Transformative Learning and Change. She may be reached for comment at firstname.lastname@example.com.


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The New Kids on the Block are back!
The band plans to bring some heat this summer when they hit the road for a brand new headlining tour – and they're bringing along a few famous friends: 98 Degrees and Boyz II Men will open all shows on the jaunt, which kicks off May 31 in Uncasville, Conn.
"It just seems like we are getting better and better," Joey McIntyre, 40, tells PEOPLE. "We're excited to get out there, rock out and have fun."
Along with the announcement of their tour, the multi-platinum selling group will release 10 – their first new album in over four years – on April 2.
"We have been doing this for almost 25 years," says McIntyre. "So it's important that the music and the lyrics speak to who we are as grown men – and the album reflects that."
But that doesn't mean fans won't see some familiar moves.
"There is a lot of nostalgia and we embrace that," says the singer. "But it always feels young and fresh. I guess that's one of the great things about being in the music business is that you never have to quite grow up."
Only on People.com
New Kids on the Block Hit the Road with 98 Degrees & Boyz II Men
Angela Weiss/WireImage


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|Mineral Deformation at Earth's Core–Mantle Boundary
Earth is a dynamic planet in which convection takes place on the scale of thousands of kilometers. Because Earth is mostly solid (except for its liquid-iron outer core), this convection causes deformation of solid rocks by plastic flow. At the core–mantle boundary (CMB), 2900 km deep, seismologists have discovered that seismic waves travel faster in certain directions. This seismic anisotropy appears to be related to the deformation of the constituent minerals. To understand the deformation mechanisms of mineral phases at this depth, researchers from Yale and UC Berkeley re-created the ultrahigh pressures of the deep Earth at ALS Beamline 12.2.2 while conducting in situ x-ray diffraction experiments to probe changes in crystal orientations.
The Earth's mantle is a roughly 2800-km-thick, viscous rocky layer that lies between the liquid-iron outer core and the relatively thin, solid crust. Elementally, the mantle consists mostly of oxygen, silicon, and magnesium, often in the form of magnesium silicate (MgSiO3). In the lower mantle, this magnesium silicate has a crystal structure known as "perovskite." However, at the lowermost mantle, the MgSiO3 is compressed into a new phase known as "post-perovskite" (pPv). Because this phase is unstable below 127 GPa, it has proven difficult to study in the laboratory.
The diamond-anvil cell (DAC) has long been used to study materials at high pressures. Only recently, however, has the DAC been applied (by the UC Berkeley group) to produce pressure and to impose stress while the incoming x-rays are brought in orthogonal (radial) to the compression direction. This particular apparatus is called the radial DAC, or rDAC. When stress is applied to a polycrystal (a solid made up of many randomly oriented crystals), individual crystals deform preferentially along slip planes. This results in crystal rotations that lead to crystallographic preferred orientation ("texture") in the polycrystal, which can be derived from analysis of x-ray diffraction images.
To understand deformation of MgSiO3 pPv, rDAC experiments were performed at the high-pressure Beamline 12.2.2 of the ALS. To synthesize the pPv phase, MgSiO3 glass was compressed to 148 GPa and was laser heated at ~3500 K for ~10 minutes. The pressure was then increased in four steps to 185 GPa. At each step, in situ x-ray diffraction images were collected to document the evolution of pressure, differential stress, and texture. Inverse pole figures (IPFs) show the probability of finding the pole (i.e., the normal) to a crystallographic lattice plane in the compression direction. In contrast to previous experiments, the group observed that at large strains, a preferred orientation pattern evolves with a maximum at the [001] pole. Comparison of the IPFs with the results of polycrystal plasticity simulations shows that the observed 001 texture is compatible with slipping along {001} lattice planes and 40% compressive strain.
When this dominant deformation mechanism is applied to large-scale geodynamic convection in the deep Earth, it predicts elastic properties in the CMB region, with fast S-waves polarized parallel to the boundary, which is just what seismologists observe. These results open new possibilities for modeling anisotropy evolution at extreme conditions, linking microscopic mineral physics properties to large macroscopic observations.
Currently, the research team has been working to develop resistive heating techniques in the rDAC experiments capable of reaching temperatures of up to 2000 K, which can be further expanded upon by simultaneous laser heating. This technological advancement is not only relevant for academic investigations in mineral physics but also adds valuable tools for studying materials at extreme conditions.
Research conducted by L. Miyagi and K.K.M. Lee (Yale University) and W. Kanitpanyacharoen, P. Karcher, and H.-R. Wenk (University of Califoria, Berkeley).
Research funding: National Science Foundation, Bateman Fellowship (Yale University), and the Carnegie/DOE Alliance Center (Carnegie Institution of Washington). Operation of the ALS is supported by the U.S. Department of Energy (DOE), Office of Basic Energy Sciences.
Publications about this research: L. Miyagi, M. Kunz, J. Nasiatka, M. Voltolini, J. Knight, and H.-R. Wenk, "In-situ texture development in polycrystalline iron at simultaneous high pressure and temperature," J. Appl. Phys. 104, 103510 (2008); L. Miyagi, W. Kanitpanyacharoen, P. Kaercher, K.K.M. Lee, and H.-R. Wenk, "Slip systems in MgSiO3 post-perovskite: Implications for D'' anisotropy," Science 329, 1639 (2010); H.-R. Wenk, S. Cottaar, C. Tome, A. McNamara, and B. Romanowicz, "Deformation in the lowermost mantle: From polycrystal plasticity to seismic anisotropy," Earth Planet. Sci. Lett. 306, 33 (2011).
ALS Science Highlight #231


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Eagles' Jones emerges top runner at meet
By Staff Reports
Published in Sports on September 5, 2009 11:06 PM
Please log in to see full story.
Other Local Sports
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- Local Preps Digest
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Source: Bloomberg
quote: Let's develop our own software industry, it is time to get rid of American dominance in that field.
quote: Linus Torvalds. - Who funnily enough, is American. (Albeit of finnish decent, but most American's have descended from somewhere.)
quote: MS comes along and uses the same tactic and their evil for it.


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BELLEVILLE - Juniata College students are finding common ground for faith in the Belleville soil.
Under a pristine sky, a handful of the young adults spent a Friday afternoon on a local farm, planting onions, potatoes and garlic for people in need.
Amid shovels and dirty hands, conversations between students began to spring up: What's your name? Where are you from? What are your aspirations?
Article Photos
Sentinel photos by MICAIAH WISE BILGER
Juniata College students plant onions, potatoes and garlic on April 13 in Belleville during a field trip with the Planting Seeds program. The national initiative encourages student groups to pursue service projects and interfaith dialogue.
Lauren Seganos, far left, leads Juniata College students in a discussion of world religions and the environment at a chapel in Belleville.
These conversations are exactly what organizers of the service day hoped would happen.
Grace Fala, a professor at Juniata College, and alumnus Lauren Seganos initiated the Planting Seeds program in response to President Barack Obama's Interfaith and Community Service Challenge.
Created by the White House Office of Faith-based and Neighborhood Partnerships, the programs challenges colleges across the country to create service programs that have the ability to build social capital, strengthen social cohesion and address social problems.
Juniata College is one of about 150 in the U.S. participating in the program, said Seganos, an AmeriCorps employee and interfaith coordinator for the Office of Diversity and Inclusion and Campus Ministry Office.
Planting Seeds, however, is the Huntingdon college's own unique program.
Seganos and Fala, who lives in Belleville, decided to create an opportunity for students to harvest crops, glean produce after harvest and perform various other agricultural jobs in the Big Valley, and at the same time learn about different religious practices and beliefs.
"Service to others and to the earth is an issue that weaves through many faith traditions - Islam, Buddhism, Judaism, Christianity," Fala said.
Seganos added they hope that by initiating conversations between faith groups, there will be less religious conflict and violence in the world.
"The project also is an opportunity to learn about religious communities (the students) haven't been exposed to," Seganos said. "A lot of Juniata students in our community are very interested in sustainable agriculture, organic farming and healthy eating, so it seemed that a service project based on the local farm community was a natural idea."
Through Fala's connections, she set up the first project last fall at two farms in Belleville. The students met several Amish families and helped harvest apples in one family's orchard.
The second Planting Seeds outing came on a recent Friday in April. A small group of college students planted crops in a donated field. In the fall, Seganos said, they will bring a team to harvest the crops and prepare them to be donated to a food bank or shelter.
After planting, Seganos led the students in a reflective session in a small chapel on Fala's farm. Together the students read texts about the shared religious value of caring for the earth, including Buddhism, Confucianism, Christianity, Hindu, Islam and Native American.
Olekander Kuzin, a student from the Ukraine, said he felt a greater appreciation and connection to the food and products he uses.
"People from the city don't know this life," Kuzin said. "It's just a chicken on the table prepared."
As the conversations grew, so did more questions and observations about different faiths.
Seganos shared that she grew up in a Christian community, but her church never really discussed environmental issues.
Kaleem Ahmed, a student from Pakistan, said he was curious about the Christian perspective of women covering their heads.
Throughout the day, too, Fala peppered the group with her knowledge about the local Amish culture.
The white-top Amish buggies represent a very conservative culture that uses oil lamps in place of battery-powered ones, which are used by the black- and orange-top buggy orders, Fala said.
Taressa King, who plans to graduate from Juniata in May, said Fala's openness to different faiths and her compassion for others left a strong impression on her.
King said the interfaith and service experiences that Fala has initiated left her feeling like a "starry-eyed child taking in wisdom and beauty."
Through Planting Seeds, Fala and Seganos said they hope the students "walk away a little more inspired."
"Every word, every thought is a seed planted," Fala said. "We have to watch how it grows. All you need to start communicating is something in common."


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Top Definition
over exstatic lovely bubbly girl.. should be queen... definately
Person: hey.. you rock
Priti: I know... I am Queen... i love nemo
Priti: I know... I am Queen... i love nemo
de sammi 12 janvier 2004
Trending Now
Can you define these popular missing words?
a branch manager, someone who loves to manage a deveshs branch. this person is a manager to the branch of Devesh (a devesh is the highest form of a pimp)
wow, that girl must be priti, shes really handling devesh's branch!!
de Benchod 5 septembre 2006


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Thursday, October 31, 2013
"I have learned over the years that when one's mind is made up, this diminishes fear; knowing what must be done does away with fear."
Rosa Parks, African-American civil rights activist
"Women need real moments of solitude and self-reflection to balance out how much of ourselves we give away."
Barbara de Angelis
"We never know how high we are Till we are called to rise; And then, if we are true to plan, Our statures touch the skies."
Emily Dickinson, American poet
"I am only one, but still I am one. I cannot do everything, but still I can do something; and because I cannot do everything, I will not refuse to do something that I can do."
Helen Keller; American author, political activist, and lecturer
"A woman is like a tea bag - you can't tell how strong she is until you put her in hot water."
Eleanor Roosevelt
"I don't know who invented high heels, but all women owe him a lot."
Marilyn Monroe
"Think like a queen. A queen is not afraid to fail. Failure is another steppingstone to greatness."
Oprah Winfrey
"If particular care and attention is not paid to the ladies, we are determined to forment a rebellion and will not hold ourselves bound by any laws in which we have no voice or representation."
Abigail Adams, U.S. First Lady, 1776
"Don't compromise yourself. You are all you've got."
Janis Joplin, American singer
"I've learned that making a "living" is not the same thing as making a "life."
Maya Angelou
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*bib pattern found here.
Oh, and I also ordered a Blythe doll. I just adore all the cuteness that I see! I'm also a little scared to admit I bought a doll. At least I have a daughter to blame it on.
Did you follow or create a pattern/tutorial for your bibs? They are so cute! Thanks for sharing!
hi madhatcher, the pattern is found here: http://www.etsy.com/shop/jcasa
I Missed You. Hope you're feeling better. I like to visit your blog because I enjoy seeing how you use bright colors and small fun prints. Also the way you play bright colors up with white. Your projects are striking and fun.
The potholders are just too adorable.
Thank you, Nettie!
Love everything! The zig zag is great - definitely on my to-do-list. I must wait for kids of my own to start buying all of the softies and dolls I want for myself... crossing my fingers for girls...
These are so gorgeous! You're such a talented quilter. :)
I wish I needed baby bibs. I want to make baby bibs. I have to make baby bibs! What a fun scrapbuster and quilting playground!
Everything in this post is just too cute! I'm excited to see what you sew up for your Blythe! Who did you get?
Those bibs are like a bouquet of flowers! So colorful and pretty!
Everything you've made is just as pretty as can be, and don't feel a bit bad about buying a doll. I never do, and I'm a lot older than you!
I think those potholders are awesome!! And so is the zigzag quilt.
they are all adorable! Your potholders are especially lovely - what sweet little houses. If only I had some babies to make bibs for - mind you, our puppy needs one for the car - she drools terribly from carsickness - I wonder if she'd wear a bib ... :-)
Love your zigzag quilt and doubly impressed that you made 2 exactly the same!
I think you're lying, you couldn't possibly have been sick! Feel better and keep stitching, everything looks great!
Cute quilt. I like the binding it makes the quilt.
The mermaid quilt is so beautiful and your sweet little projects are just so sweet!
Wow, I just love those ocean-themed fabrics! You use such great color combinations in your work :)
your work is beautiful, I adore your little bibs :)
Adorable bibs.
i just love these! too cute!
Thanks for sharing where you got your pattern! I ordered it yesterday. I've been wanting to make some bibs after seeing yours...but hate to be a copy cat! Now I don't have to feel bad! I like to support other hard working mamas! So thanks to J Casa too! But I might just have to copy those pot holders...so cute!
I used your tutorial to make one almost exactly like this. I love the Mendocino line, and I, too, adore zigzags. It's basted but not quilted yet.
I love looking through your blog! All your patterns/tutorials are wonderful! I was just wondering what fabric you used for the doors on the potholders. Those little girls are adorable!
these are the cutest potholders and bibs I have ever seen!
very nice and sweet. looks like it was made by hands, isn't it? or it was?? ...........
How did you quilt your zigzag quilt together? I'm new to quilting and I love the way it looks. Would I need to take it somewhere to get that quilt design?


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Silver Linings Playbook dominated the Independent Spirit Awards on Saturday, taking home four awards, including Best Feature, Best Director and Best Screenplay for David O. Russell and Best Female Lead for Jennifer Lawrence.
Check out TVGuide.com's complete Oscars coverage
The Sessions also fared well, with John Hawkes winning for Best Male Lead, while Helen Hunt took home Best Supporting Female. Best Supporting Male went to Matthew McConaughey for Magic Mike.
Check out the full list of winners below:
Best Feature: Silver Linings PlaybookBest Director: David O. Russell, Silver Linings PlaybookBest Screenplay: David O. Russell, Silver Linings PlaybookBest Female Lead: Jennifer Lawrence, Silver Linings PlaybookBest Male Lead: John Hawkes, The SessionsBest Supporting Female: Helen Hunt, The SessionsBest Supporting Male: Matthew McConaughey, Magic MikeBest First Feature: The Perks of Being a WallflowerBest First Screenplay: Derek Connolly, Safety Not GuaranteedJohn Cassavetes Awards: Middle of NowhereBest Cinematography: Ben Richardson, Beasts of the Southern WildBest Documentary: The Invisible WarBest International Film: AmourPiaget Producers Award: Stones in the Sun, Mynette LouieSomeone to Watch Award: Gimme the Loot, Adam LeonTruer than Fiction Award: The Waiting Room, Peter NicksRobert Altman Award: Starlet
View original Silver Linings Playbook Dominates at the Spirit Awards at TVGuide.com
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Serves 7 |
Prep Time 10 minutes |
Cook Time 30 minutes
2 Tbsp Eden Extra Virgin Olive Oil
1 pound leeks, well cleaned and sliced, use white and green part
3/4 tsp Eden Sea Salt
1/4 tsp freshly ground black pepper
30 ounces Eden Cannellini (White Kidney) Beans, rinsed and drained
3 1/2 cups vegetable stock
1/2 tsp ground sage
14 ounces Eden Spelt Spaghettior any Eden Spaghetti
2 Tbsp lemon juice, freshly squeezed
1/2 cup organic parmesan, finely grated, optional
1/4 cup fresh parsley, coarsely chopped
In a large skillet heat oil over medium-low heat. Add leeks, salt and pepper. Cook until soft, about 10 minutes. Add beans, broth and sage. With a potato masher, mash about 1/3 of the beans. Bring to a boil, reduce to a simmer. Cook until lightly thickened, about 5 minutes. Cook pasta for 2 minutes less than package directs. Drain. Bring bean and leek sauce to a simmer. Add lemon juice and parmesan. Mix. Add pasta and cook 2 minutes, stirring until heated through. Serve sprinkled with parsley.
Beans, Condiments, Good/High Fiber, Good/High Protein, Italian, Macrobiotic, Main Course, No Sweetener Added, Oils, Pasta, Vegan


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Westminster's Paleontology Program
Why Study Paleontology at Westminster?
Paleontology focuses on understanding the history of life and includes principles from geology, biology, astronomy, chemistry and physics. If you're interested in searching out the Earth's and history's secrets through scientific discovery, paleontology combines several disciplines and brings life to the ancient past.
This interdisciplinary academic minor focuses on the historical study of biological diversity. By drawing together courses from both biology and earth systems science, the paleontology minor is an excellent option either for students specifically interested in life of the past, or for students interested in how different branches of science approach the same complex problems. The curriculum prepares students for future work in paleontology, historical geology, or organismal biology, as well as providing a broad background in the natural sciences in general.
The Westminster Difference:


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Suspect Caylon Lidik was 16 at the time, police say
A Rockledge man faces the possibility of life in prison for the rape of a 7-year-old girl.
Caylon Lidik, 22, appeared in court Thursday after his arrest Wednesday night.
He's charged with sexual battery on a child younger than 12 and lewd and lascivious molestation.
A police report says the alleged crimes occurred about six years ago, when Lidik was 16.
The report says Lidik made the girl perform sex acts repeatedly over the course of about two months.
Police are not saying how the suspect and the victim knew each other.
A judge ordered Lidik held without bail and also ordered that if he is granted bail in the future, he can have no contact with anyone under 18 without adult supervision.
Related: Florida mug shots
Copyright 2013 by WESH.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Summer shoes are one thing I don't like to splurge on anymore. Maybe it's the cobblestones or my not-so-graceful walk, but my strappy sandals are always a tattered mess after I've worn them in Charleston all summer.
That's why I aim for the $20-$30 range when I'm shopping for seasonal shoes. It's a challenge, yes, and maybe it's not for everyone. But if you like to look fashionable and you don't care about the big names or Italian leather, then this guide to shoe shopping is for you.
Here are the best summer shoes I found around town and on the web for $30 or less:
Versona Accessories in Mount Pleasant Towne Centre has a great selection of budget shoes. Manager Mary Desaussure likes Versona's brand of rhinestone sandals that are $18.
"They're so cute. I already bought a pair for myself," she said. "We have so many pairs of sandals, and almost all of them are under $30."
Sandals aren't all they carry. Versona had plenty of dress shoes and flats to choose from, too. I found pairs of colorful striped flats by Bamboo for $16, which I immediately fell in love with. Bamboo is one of my favorite brands because they're well-made and reasonably priced.
To see more styles by Bamboo, check out Tillys.com. They carry several styles of sandals priced $15-$25. I love the Laguna sandal for $20. It's a subdued gladiator style that seems like it would go with any outfit.
If you're looking for basic thong sandals, Payless has some by American Eagle for $20 in blue, black, white or tan. With their buy-one, get-one-half-off deal, you can get two pairs in different colors for $30.
Another style that seems to be pretty popular this year is a sandal with an ankle strap and a thick strap across the toes. I know it sounds minimal, but they're actually very comfortable. Piperlime.com has a pair called Debby-1 by Pierre Dumas for $29. I love the bold teal and orange pair, but they come in black and brown as well.
The Faux Leather Cross Front Sandal at Old Navy is a similar pair that features a small wedge heel for a little more height. Find them at the Tanger Outlet store in North Charleston on sale for $23.
Another low-wedge sandal I like is the Lily sandal by Covington at Sears. The gladiator-style features braided straps on the top and a zip-up ankle. They're dressy enough for work, they're comfortable and they're on sale for $20.
I try to stay away from high heels, so I go for platforms or wedges when I want a little more height. Charlotte Russe always seems to have good deals on expensive-looking wedges. The Strappy Cork Wedge Sandal is $15 when you buy online. If you buy the full-priced pair for $32.50 in stores, you can get a second pair of any shoes for $12.50.
When you go shoe shopping this summer, just remember that strappy sandals and low-cut flats are not built to last. If they wear out quickly, which I've found to be true for even the high-end brands, you'll be a little less bummed if you didn't pay too much for them.
Reach Abigail Darlington at firstname.lastname@example.com. See local daily deals at charleston savvyshopper.com.


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Top Definition
A homo-sexual bicurious man who has never ever been within several feet of a woman. He fears them as if he were a mouse and a cat was after them. His little brother is 2 years younger and tapped 50,000 more women than him.
What a "Colin Murphy," EWWW!!! He doesnt even like woman and he uses CEDAFIL!!!!!
von AsSHOLee4454 17. November 2009
Trending Now
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Tiffin reports
A possible attempted break-in was reported Wednesday afternoon at Fort Ball RV & Auto Sales, 582 N. Sandusky St.
A 100-block South Sandusky Street man reported Wednesday afternoon he had been scammed out of $1,800 on the Internet.
A person flagged down an officer Wednesday afternoon near the railroad crossing on North Monroe Street to report vandalism.
A person went to the station Wednesday evening to report possible child endangerment.
A 200-block North Washington Street woman reported damage to her vehicle Wednesday night.
A first-block Coe Street woman reported Wednesday night her 15-year-old son assaulted her.
A 600-block South Sandusky Street woman requested to speak to an officer Wednesday night about a babysitter spanking her child.
A caller from Kroger, 790 W. Market St., reported early Thursday morning a couple of customers were opening cosmetic products, trying them and putting them back.
A caller from North Central Academy, 928 W. Market St., reported Thursday morning a student was threatening to kill another student. The staff had the student isolated.
County reports
Dylan J. Warnick, 22, of Tiffin, was charged with criminal damaging in relation to an incident Oct. 10.
A 100-block Eighth Avenue man requested a deputy Wednesday afternoon in reference to a person who cut down his tree.
A caller reported early Thursday morning a four-wheeler was sitting by a ditch in the 10,000 block of East US 224.
A 9000-block East US 224 man reported Thursday morning someone took his truck during the night.
A 100-block North TR 165 person went to the station Thursday morning to report fraudulent charges.
Fostoria reports
A 700-block Westhaven Drive woman reported Wednesday evening someone had tried to break into her residence within the last few days.
Sandai A. Harris, 38, of Michigan, was cited with operating a vehicle while intoxicated early Thursday morning. He also was cited with a turn signal violation.
A 1500-block North Countyline Street caller reported Thursday morning a man with a BB gun was riding around on a scooter attempting to shoot a dog. The dog was released to the Wood County Sheriff's Office.
A caller from Wagner Lincoln Mercury Inc., 1600 N. Countyline St., reported Thursday afternoon a bullet hole was found in a vehicle window.
County accident
A two-vehicle accident was reported Thursday afternoon at West US 224 and SR 53. A person was issued a citation for failure to maintain assured clear distance ahead and at least one person was transported to Mercy Tiffin Hospital. Further details were unavailable.
Tiffin fire
Firefighters were called to 78 Shaffer Park Drive for a fire alarm Thursday morning.
Fostoria fire
Firefighters were called to 1270 Van Buren St. Thursday morning for an open burn.
County fire
Green Springs firefighters were called to North Broadway Street Wednesday evening for a fire alarm.
Bascom firefighters were called to West US 224 and SR53 for an accident Thursday afternoon.
McCutchenville firefighters were called to West CR 90 Thursday afternoon for a wood pile fire.


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They won't talk: Parkland officials, county judge meet privately about hospital board member Luna
Fresh intrigue surrounds Dallas County Commissioner John Wiley Price's effort to remove lawyer Chris Luna from the Parkland Memorial Hospital board.
Board chair Dr. Lauren McDonald (right), whom Price appointed, and Parkland boss Dr. Ron Anderson (lower right) described their concerns about Luna this morning in a closed-door meeting with Dallas County Judge Jim Foster. Foster, who appointed Luna, wouldn't tell me what those concerns were.
"It would be premature till I get to the bottom of it," he said. "I'm in the fact-finding mode."
McDonald and Anderson also were mum. "It was just a private meeting, and I don't really feel it's something that should be discussed," McDonald said.
Luna has praised Parkland's top staff lawyer, Michael Silhol, whom the hospital — for reasons that haven't been publicly stated — is paying a year's salary to quit. Silhol has overseen the hospital's response to federal investigations of patient harm, employee theft of narcotics from hospital pharmacies and potential billing fraud.
Price, not normally known for being shy, declined again today to tell me why he's targeting Luna. The matter was discussed in closed session at last week's Commissioners Court meeting and could be back on the agenda next week, he said.
Luna said he still doesn't know what's going on. "Neither Lauren nor Ron has expressed any concern to me," he said.


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(adj) something that is so supremely awsome, good, or exciting that merely thinking of it might infact make you jizz yourself
oh my god, did you see that trailer?! that movie looks jizztastic!... oh shit, gimme a minute I need to clean up.
de thezongo 17 décembre 2009
Trending Now
Can you define these popular missing words?
Top Definition
good enough to make you soak your pants with semen, better than fantastic; something so wonderful, you just cannot contain yourself
Winning the lottery is jizztastic experience.
de Nebuchadnezzar 9 janvier 2004
When something, either an event, object or person, is so good that you almost jizz yourself i.e. ejaculate in your pants.
God that is absolutely jizztastic
de Davetherave 31 janvier 2006
word used to describe something that is really amazing
dude that hot tub was jizztastic.
de da jizzanatoR 15 juillet 2010
Something so fantastic that it makes you jizz.
This song is jizztastic!
You look jizztastic today!
You look jizztastic today!
de lolicakes 8 février 2011
When something is so fantastic, that you instantly cream your pants with jizz, semen, sperm-juice, etc.
Damn homie, that criossant was jizztastic!
Wasn't that episode of Digi-Mon jizztastic?!
Wasn't that episode of Digi-Mon jizztastic?!
de Bay City Bird Slapper 6 avril 2011
Used for a sexual joke reply. or used to define something very awesome.
Jack: "Hey did you hear about that one joke about those two girls and camel?"
Jill: "No, but i bet it was jizztastic."
Jill: "No, but i bet it was jizztastic."
de iShoulddaPulledOut 10 octobre 2011


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Top Definition
A part of the short-term memory where images of attractive people you've recently seen or briefly met reside. This provides mental fuel for masturbation in the future.
Guy #1: Man, did you see that hottie that just asked me for a light?
Guy #2: One more for the Tug Locker.
Guy #2: One more for the Tug Locker.
por Cynicanadian 29 de Agosto de 2012
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Can you define these popular missing words?


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Hallelujah ChorusG. F. Handel/arr. Hal Hopson - Hope Publishing Company
Don't miss this opportunity to sing the magnificent Handel classic! In the key of C, Hal Hopson's setting is every bit as effective as it is practical for today's choirs. Comfortable choral ranges, optional congregation parts, and a wide variety of instrumental combinations, including handbells, with organ accompaniment, make this a very versatile and accessible edition. Include everyone in your celebrations at Easter and Christmas.
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Last week Twitter launched their new interface, which included brand pages with some added features. A limited numbers of partners had access to these brand pages, including B2B companies Dell, General Electric and Intel. One of the interesting features is the ability for companies to pin a tweet to the top of their stream, so it is always showing. Each of these three companies realized this was a perfect place for an embedded video, as Twitter now shows video within tweets. As these pages roll out to others, each approach gives you something to think about when planning your own B2B companies pinned tweet.
Dell featured the new Twitter video, which explains some of the new features. This provides some value to their followers in the form of education. General Electric shared a video showing the variety of products they make, and they used the number 140 to tie it to Twitter. Diversity of products and services is key part of who GE is. And Intel featured a customer unboxing a product. This simple customer shows the important of technology to our lives, and Intel is a part of that. Screenshots of each page are below, as well as each video.
General Electric
What do you think of their use of the pinned tweet, and what will you use for your B2B company pinned tweet when this feature is widely available?


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Saucony Grid Excursion TR 8 Trail Running Shoe - Womens
Looks like you've got more shoe shopping to do - have fun!
Hit the trails and be ready for any terrain you may encounter in the women's Excursion TR 8 from Saucony! With aggressive, multi-directional lugs and Heel Grid technology, this trail shoe will take your running to the next level.
This women's running shoe is best for the neutral runner. What is pronation?
- Durable mesh and synthetic upper for lightweight support
- Lace-up closure
- Pull loop at heel for easy on/off
- Padded collar and tongue for comfort
- Soft fabric lining
- Removable cushioned insole
- Heel Grid technology provides impact protection
- Molded EVA foam midsole provides lightweight cushioning and shock absorption
- XT-600™ rubber outsole with aggressive lug pattern for traction and durability over all terrain
- Weight: 9.4 oz (women's size 7)
- Imported
- View more Saucony
*Your pronation type is determined by the natural motion your feet apply throughout your running gait. When you pronate your foot rolls from either the outer edge, inner edge or not at all. If your foot rolls to the outer edge when you run, you are an underpronator, if it rolls to the inner edge you are a overpronator and if your foot doesn't roll at all you are a neutral or stable runner.
Find the the best running shoe for your pronation type :


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Enjoy the Grand Prix Final preview and feel free to share your thoughts!
You can also comment on the Juniors in this thread.
Enjoy the Grand Prix Final preview and feel free to share your thoughts!
You can also comment on the Juniors in this thread.
My greatest respect to such a thourough preview, must have took lots of energy ....
I'm a little worried for Akiko, since the situation is similar to her 4CC participation last season.
I hope this time she can be free from feeling being gifted a big chance.
She shouldn't feel obligated, she earned and deserves her spot.
Very interesting cast in all disciplines.
Who broadcasting by Internet?
Yes-s-s-s! for Skatebuzz. It wasn't showing earlier in the day and I was going into panic mode...now I feel better.
That article was good in some respects, but does anyone actually expect Leonova to medal? I'd expect her to be closer to the bottom, and Akiko too because of her edge calls. I think Wagner should probably be ahead of both of them if she skates well. Ashley could even beat Joannie if Joannie does a repeat of her SC freeskate....which would be bound to score much lower not in Canada. Alena is cute and has a lot of energy but she seems the most juniorish of the bunch, I wouldn't be surprised if she was 6th, but maybe i'm not giving her enough credit. The author of the article certainly seems to think she's great
I don't agree with the author's pick of Leonova above Rochette (unless she has another SP breakdown), but I think Leonova's chances of medalling are about the same as Wagner's. But I think they'll only medal if Ando and/or Rochette skate below their usual standard.
I don't see Evan winning this, the only predictions in the article I agree with were the dance.
Do you think one of the otheres will beat Kim? She's shown she's vulnerable, but so have the others.
I think Evan has as good a chance at claiming the gold as any of the men. He's for sure the most consistent and imo strongest mentally and is also showing the most improvement from one event to the next. Slow and steady wins the race! My bet's on him.
Last edited by merrybari; 12-01-2009 at 10:49 AM.
1.) Yu Na
big gap
2.) Miki, Joannie
smaller gap
3.) Ashley, Alena, Akiko
Within groups 2 and 3 the order of the ladies in them is very hard to predict. It should be really close between 4th and 6th, maybe even 2nd and 6th. But I guess that's what happens at the grand prix final
Well switch Alena and Akiko and your Ladies predictions would have been spot on! :D Pretty good job getting 4 out of 6 correct!
Haha completely random; but half of the Ladies first names begin with an 'A'. I can picture it at the Olympics; th 4 A's underdog team; Ashley, Alissa, Alena and Akiko...
Last edited by Trewyn; 12-05-2009 at 11:45 AM.
^^ I enjoyed Amelie's programs a lot at SC! I hope she makes the team (instead of Cynthia)!
Two more A ladies; Annete Dytrt and Anastasia Gimazetdinova, now joining the the 7 A's underdog team.


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WELLSVILLE - The belief that the Christmas spirit should extend to everyone, including four-legged friends and family, provides the motivation behind "Christmas for the Animals," which will be held at 12:30 p.m. Sunday at the Fourth Street Gazebo in Wellsville.
Village resident Connie Carmichael, coordinator of the event, said that all local pet parents and animal owners are welcome to stop by and pick up food, toys, treats, blankets, straw and other pet supplies, free of charge. "Our goal for this is to bond humans and animals, and what better time than in the middle of Christmas?" she said. The bonding will even include a visit by Santa Claus, who will take photos with the pets in attendance.
The gift items were purchased with private donations and from members of the Alley Cat Aid Brigade, a stray cat rescue group of which Carmichael is president. Also this year, proceeds from the annual Village Yard Sale held by the Wellsville Revitalization Committee in October were donated for the effort. Though cats are welcome at the event, Carmichael requests that they be brought in carriers to prevent any feline escapes.
Article Photos
"Christmas for the Animals," a holiday party for pets and pet owners of all stripes, will be held at 12:30 p.m. Sunday, Dec. 16 at the Fourth Street Gazebo in Wellsville. Free toys, treats and other pet gifts will be available to all attendees. Ready for this year's edition are (from left): Ruth Ansinger, Wellsville Mayor Susan Haugh, Connie Carmichael, Beverly Hentzell and Angel, Columbiana County Humane Society President Jenny Pike, Sharon Buswell and Clyde, Wellsville Police Officer Marsha Eisenhart, Mac Comparetto and Pino, and Debbie Comparetto. (Photo by Richard Sberna)
Carmichael said her inspiration came from learning about "Christmas for the Horses," an event organized by Anna Harris Smith of the Animal Rescue League of Boston in 1916, when horses were still commonly used as draft animals. League members provided oats, carrots and other treats for all the horses pulling wagons and carriages out on the street, as well as boxed lunches for the drivers, who were exposed to the elements in those days.
Carmichael thinks the scarcity of pack animals today doesn't negate the need for a similar gesture of kindness. "We don't have a lot of horses, but we certainly have dogs and cats," she said. "I thought, that's something I would really love to do."
In addition to the gift-giving, a local person involved with animal advocacy is recognized for their efforts at the event. This year's honoree is Jenny Pike, president of Humane Society of Columbiana County. Pike said that she is humbled by the selection and credited the good works performed by the organization to the team of volunteers who make up its staff.
In her five years as president of the Humane Society, Pike listed its institution of a no-kill policy as the one she's most proud of, meaning every animal that comes through their care has a second chance. "That wasn't me; that was a very courageous board of directors," she humbly said.
Pike says her chief duty and biggest challenge is fundraising, since the nonprofit agency runs solely on donations and is staffed by volunteers. Additionally, she works to highlight what she calls the correlation between animal abuse and human abuse, as well as the educating public of its impact. "If you're a community leader, you have to understand that there's a person behind that neglect or that abuse, and many times, there are children in that home that are getting neglected or abused as well," she said.
The society also sponsors humane agents, who investigate cases of suspected abuse or neglect. The agents are trained in spotting abuse, sworn in by the county probate court and permitted by law to look in on the animal and its welfare. Pike emphasized that this service is not paid with taxpayer funds, but as a service to the community. She says that education is always the first goal when a problem is found.
"The last thing we want to do is take an animal out of a loving home," she said.


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Lunch & Learn: Proactive Health & Wellness
Main Parlor, 1st Floor Main Building
Tue Sep 9th, 2014
12:00 p.m. - 01:30 p.m.
William Peace University welcomes Dr. Josh McMillon from Proactive Health & Wellness in Raleigh, NC for the kick-off Lunch and Learn Series event on September 9, 2014 at 12:00 p.m.
Dr. Josh McMillon will speak on "Understanding Stress" for faculty, staff and Season Ticket holders.
Dr. McMillon has a doctorate from University of Western States in Portland Oregon. His doctorate includes a masters level in nutrition all rolled into his doctorate program. He has also completed additional certifications in functional blood chemistry and nutrition from Apex Energetics and Standard Process seminars.
Proactive Health & Wellness has been part of the community for five years and is committed to giving back to many area nonprofits, helping ensure that the people of our community have opportunities to live well and live long.
Tickets: Free Admission for WPU Faculty and Staff, and Season Ticket Holders.


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Hello, I am embarking on a large project to redesign an online reporting tool for a non-technical audience.
Background: Today, this tool exists in an online service for a very large non-technical user base. The reports are very important to this user base to track personal sales, team sales, personal data and team data. The user base itself is largely non-technical, and generally are not very interested or familiar with reporting tools and often refer to themselves almost as scared of reports in general.