text:
Apple isn't a design company, it's a fashion company
100 Comments
1. Johnnokia (Posts: 1093; Member since: 27 May 2012)
If Apple creates fashionable designs, what would say about Nokia ??!!.
6. Friendlysky (Posts: 54; Member since: 04 Jul 2012)
If you old enough to know history you might know that Nokia has being design and build their owned parts themself. They do not ask others company to build screen and chip for them like apple. Apple is a design company they are not an electronic company. I totally agreed with them.
46. neutralguy (Posts: 1152; Member since: 30 Apr 2012)
Actually, nokia don't manufacture those parts either, rather, get some other companies to manufacture it. Do you think, nokia manufacture its camera sensors? No. Screens? No. Polycarbonate plastic case? No.
Both of them are electronic/"phone designer" companies, no argument needed.
75. PhenomFaz (Posts: 1236; Member since: 26 Sep 2012)
Apple is a fashion company and not a very good one at that! Just take a look at the iPhone 5...nicks, scratches, paint wear-offs...at least apple should've gotten their fashion right since they clearly sacrificed functionality for fashion!
79. darkkjedii (Posts: 21327; Member since: 05 Feb 2011)
How a bout the gs3's cracks between the camera and speaker and along the sides.
87. PhenomFaz (Posts: 1236; Member since: 26 Sep 2012)
the discussion was never of a samsung product you noob. Samsung may or may not have flaws it doesn't bother me...I am an android guy and that doesn't only mean sammy but sony, htc, moto, lg, etc.
And if the gs3 was so bad then it wouldn't have become the most pre-ordered electronic device in history and the single largest selling phone with over 30 million units! even in the week when iphone 5 released the gs3 sales spiked upwards and are still going at a steady rate whereas iphone 5 drama has fizzled out...!
Admit it...you know it...I OWN you TROLL!
99. Nadr1212 (Posts: 741; Member since: 22 Sep 2012)
I just wasted 5-10 mins of my life just to read this stupid article.
This is time I will NEVER get back no matter what
50. JeffdaBeat (unregistered)
And we see where that got them...
I'm sorry, but you cannot for a moment say that Apple isn't an electronic company. Luxury vehicle companies get components of their cars from other vendors (as does Ford, GM, Chrysler), but we still call them car/automotive companies. Arrow Dynamics was a roller coaster company, but they didn't manufacture or build the coaster themselves. They used Morgan Manufacturing to do it. Does that make them any less of a roller coaster company? I'd argue no.
Apple champions design, yes. They want their products to look good on your desk or when you're out. They want it to attract the eye so it can stand out from its competition. We see this in all areas of advertising and packaging of products. But what is fashion is based on the user. I didn't buy my iPhone to be fashionable especially since I usually wear jeans, Chucks, and a black hoodie everywhere I go. I bought it because it works just as well 2 years later as it did the first day I bought it. I cannot say the same about my old Blackberry, HTC Mogul, Palm Treo, or HTC Touch Pro (all companies I think we'd consider electronics companies). I didn't buy my iMac (something no one usually sees) because I want to show how well off I am (which I'm not). I bought it because I've literally never had to reformat a Mac since I started using them. Same goes with most of the Apple products I've purchased. I can't say that for the PC's I've owned and I was a BIG Apple hater back then.
Now, if Apple made legitimately crappy products...and not just what folks around here might call crappy because they don't like Apple...but universally critically panned products that just looked good, I'd be right on board with calling Apple a design company and their products fashion statements. But it's simply not true. Their products are not only critically acclaimed for their design, but their usability as well. And this isn't me just being a fanboy. You can look these reviews up yourself by professionals whose jobs are to review multiple products of all kinds of quality.
I understand why Apple may not work for you personally. I totally get it. But taking what the company has done and how it has changed the entire industry in just the course of these 5 years since the iPhone and saying...well Apple is just a design company...is just crap. Folks mocked the iPad, but tablets were dead in the water before it, now we've got every mobile phone company making one. You may hate FaceTime, but it finally took video streaming away from the carriers and put it in the hands of the handset creators (you should have seen the ridiculous price AT&T charged for their video share). People mocked the MacBook air, but all of a sudden all these UltraBooks appeared.
Apple designs every aspect of their products. If we are to criticize them for using vendors for parts, then there are a LOT of companies in other fields that we will have to do the same with. Apple is an electronics company.
71. ilia1986 (unregistered)
Jeff - the problem is that unlike other companies - Apple isn't willing to play nice with the competition - and because of the ridiculous patent system - it is a threat to anything and everything tech-related which is somehow competitive with it.
Company ethics aside - Apple is the only company which purposefully restricts it's product's functionality - so it can add it later on and call it a "revolutionary new feature". Were not talking here about small stuff. iOS users can't yet send files via email ffs.
You ARE right about one thing though - Apple isn't a fashion company - my SGS3 is arguably as recognizable as an iPhone. Heck, according to the jury of Samsung trial - they look the same (lol).
it's however amusing to read Michael's different explanations for why many people hate Apple (according to him - we just don't understand Apple) lol.
Have a nice day, y'all. :)
Sent from my Galaxy S3.
81. darkkjedii (Posts: 21327; Member since: 05 Feb 2011)
Wowwww Jeff. That's an awesome post bro. One can really see the thought that went into it, your input isn't even refutable. Very well said +1 bro.
84. ZEUS.the.thunder.god (unregistered)
+1 bro and I totally agree with you.
Apple make good products however I hate Apple for its rotten business practices and ethics. As illia1986 said Apple is not willing to play fair. They want to eliminate competition by hook or crook. Now thats the number one reason many people just hate apple.
72. Johnnokia (Posts: 1093; Member since: 27 May 2012)
common guys, it is a sarcasm ,,
Nokia is million times better than Apple.
sorry for misunderstanding
74. Nathan_ingx (Posts: 3782; Member since: 07 Mar 2012)
Whatever you say John.
But i'll stick with the headline! :)
Honestly, it's personal preference...it's like debating over which came first, the chicken or the egg.
It won't end... Apple lovers will defend, Others will offend.
98. Nadr1212 (Posts: 741; Member since: 22 Sep 2012)
39. fanboy1974 (Posts: 1345; Member since: 12 Nov 2011)
Dead in the water?
66. kevkyle (Posts: 102; Member since: 21 Oct 2012)
yOU Have got to visit engadget...It's martial law out there - comments against the IPad mini review are DELETED by moderators and the writer Tim Stevens - in real TIME.....absolutely outrageous....not Kidding!
....they banned commenters from Pocketnow too....anything against apple are deleted from their threads . Unbelievable!
68. RaKithAPeiRiZ (Posts: 1488; Member since: 29 Dec 2011)
This was very common ...i used to get banned every week when they had disqus on engadget
69. kevkyle (Posts: 102; Member since: 21 Oct 2012)
never once did i think nor believe techbloggers were on apple's payroll......sounded insane - ", ) - guess am wrong.....
now they're openly flaunting....clueless me, haha
88. MichaelHeller (Posts: 2703; Member since: 26 May 2011)
I haven't checked out the sites, but I'm curious on one point: are comments being deleted just for saying the iPad mini doesn't look good, or are comments being deleted because people can't stop directly attacking Apple and starting flame wars?
2. jaoowolabi (Posts: 201; Member since: 07 Jun 2012)
Oh is that what is is now?
53. maxican16 (Posts: 364; Member since: 29 Sep 2011)
Yeah, that was my thought as well, but I tried to keep an open mind. I can see what the author is getting at.
So as android continues down the path set by Matias Duarte, and becomes more "fashionable" with its hardware design as well (it's already there in terms of software), even to the point it equals the attention to detail present in the iphone, then Apple is REALLY in trouble.
......I don't think that time is very far off.
3. pongkie (Posts: 538; Member since: 20 Aug 2011)
apple don't make fashionable designs they make simple designs.
5. AppleConspiracy (Posts: 637; Member since: 18 Oct 2011)
Fashionability is not a matter of simplicity or complexity.
10. pongkie (Posts: 538; Member since: 20 Aug 2011)
come on apple may be a form of art but its not fashionable. most of thier products are aluminum where's the fashion in that.
17. AppleConspiracy (Posts: 637; Member since: 18 Oct 2011)
It looks like you know what fashion is. So, what is fashion?
18. pongkie (Posts: 538; Member since: 20 Aug 2011)
something that make you stand out from the rest.
21. brandnew234 (Posts: 18; Member since: 12 Aug 2012)
So you couldn't tell an iPhone from ANY WP phone, or an Android (excluding iPhone copies)?
23. AppleConspiracy (Posts: 637; Member since: 18 Oct 2011)
If something is fashion, that means it's a trend (recognizable), so it's exactly opposite of unique and does not stand out.
35. pongkie (Posts: 538; Member since: 20 Aug 2011)
Fashion is something iFans would not ever get. Fashion is also daring, new, adventureous, head turning.
walk in a mall with that black turtleneck and no one would care, then try out an outfit that is unique, fresh, daring, sexy(must have the body) and you'll know what fashion is.
Try going out with your friends and bring an iphone 4, iphone 4s, ip 5 and try switching it during that time. your friends wouldn't even notice that you actually used 3 different iphones in that day or do it with the different generations of ipad same thing.
67. Commentator (Posts: 3692; Member since: 16 Aug 2011)
What are you talking about? How is fashion anything other than what the socially accepted norm of appearance is? There's a reason "out of fashion" and "in fashion" are phrases. Lady Gaga (if she still exists) always runs around in weird "daring" styles, but I definitely would not call "her" fashionable.
20. brandnew234 (Posts: 18; Member since: 12 Aug 2012)
Fashion is opinion, you can't argue a favorite color, it's stupid. I personally love Android for the customization&screens, but I prefer the feel of an Apple product in my hand. Aluminum is a premium feel, so is glass. Plastic reminds me of toys and containers, large glass windows are seen as premium.
28. TROLL (banned) (Posts: 4851; Member since: 13 Apr 2012)
Well true saying, fashion is like Prada D&G Armani Ralph Lauren Paul Smith Hugo Boss, they use premium materials and stitching designs. Apple dosen't use ceramic nor Carbon-Fibre nor Kevlar or Liquid Metal..... What a joke!
89. MichaelHeller (Posts: 2703; Member since: 26 May 2011)
that's one of the odd things about the discussion: things that are fashion aren't necessarily fashionable, the two ideas are very different. Fashion is the product itself and the intent of the product. Fashionable is the public reaction to the product.
Fashion is also a highly subjective topic, what looks good to one won't look good to everyone. You may not like the fashion of Apple, but that doesn't mean it isn't fashion.
26. TROLL (banned) (Posts: 4851; Member since: 13 Apr 2012)
The macbook air design stolen from Sonys Zseries. Only highend rich people use Zseries laptop!
The ip4 with ugly curves is no concept. Pansonic Eluga is a fashoin stlish phone.
True Apple is just a simple design with cheap material along with high price, but hardware are premium. Exynos, PvrSgxMp3...
47. quakan (Posts: 1373; Member since: 02 Mar 2011)
Lots of rich people use Mac computers. Tell me the last time you turned your T.V. on and saw a rich person without one, or better yet used a Z Series laptop? I have a MacBook Pro and I'm far from rich, just like I'm sure there are middle class people with Z Series laptops.
4. AppleConspiracy (Posts: 637; Member since: 18 Oct 2011)
Designism is the enemy of design.
Designism is Microsoft. Design is Apple.
Because design is a surplus value of a form. And designism is the ideology of design, design for design's sake. That's why Jony Ive talks about "no-design" in his designs.
Nice article!
13. Captain_Doug (Posts: 997; Member since: 10 Feb 2012)
and water... is the essence... of beauty....
7. wassup (Posts: 565; Member since: 23 Jun 2011)
great article as always, Michael..
Apple is wannabe hipster, and it's the only reason wannabe hipsters spend money on it. That's it.
Android is a mixed bag, you have beautiful designs like the One X and the mixed bags like the S3/Note
Windows Phone is just... Colorful, the best way i can put it. But most of them look good though, just the 920 looking a bit stale.
there. my $0.02
14. Captain_Doug (Posts: 997; Member since: 10 Feb 2012)
Windows is colorful huh... flamboyant even.
15. wassup (Posts: 565; Member since: 23 Jun 2011)
definitely! not for me though.. there's such a thing as too colorful lol.
85. Captain_Doug (Posts: 997; Member since: 10 Feb 2012)
Agreed. I like my phones a bit more tasteful. Ergonomics is way more important to me in a phone then color. Not that you can't have both but I don't need/want my phone to make a statement for me. I don't think of my phone as an accessory, it's a tool.
9. bradley.block (Posts: 6; Member since: 01 Oct 2012)
This is probably the best article I have read on PH in a long time. For once hopefully people will start to see why Apple is who they are and why Google is Google. And why we choose the devices that we choose.
25. weinerslav (Posts: 126; Member since: 31 Jul 2012)
Fashion is not about being a follower, by the large volumes it sells, you can say is because of the design, but never because is fashion, people picks apple because of simplicity, like they picked nokia before...
37. MichaelHeller (Posts: 2703; Member since: 26 May 2011)
Why is design different from fashion? If people buy a shirt because it looks good, that's fashion, but if people buy an iPhone because it looks good, it's not?
54. weinerslav (Posts: 126; Member since: 31 Jul 2012)
It's different... there are great designs that aren't fashionable, and the opposite is even easier to find!
57. MichaelHeller (Posts: 2703; Member since: 26 May 2011)
What's fashionable and what is fashion are two very different things. The Gap has fashion, but so does Dolce & Gabbana.
64. weinerslav (Posts: 126; Member since: 31 Jul 2012)
So are fashion and trends...
90. MichaelHeller (Posts: 2703; Member since: 26 May 2011)
Exactly. Fashion is more in the intent of the creator. What's fashionable or trendy is based on the reaction of customers.
Apple is definitely intending to be fashion, and there are a lot of people out there who find Apple to be fashionable.
11. Captain_Doug (Posts: 997; Member since: 10 Feb 2012)
This is so well written. Good job Michael. Good job.
12. Sniggly (Posts: 7305; Member since: 05 Dec 2009)
This is a fair article. It's also something many of us here would readily acknowledge. Hell, even Verizon and Motorola recognized this. It's why, in one of their original ads for the Droid, they indirectly attacked the iPhone for being pretty yet less functional. The end of the ad said "It's not a princess, it's a robot. A phone that trades hairdo for can do."
16. AppleConspiracy (Posts: 637; Member since: 18 Oct 2011)
How is that iPhone is less functional? It's intended to be functional as it is. It carries its function perfectly. Only if you think from an Android standpoint it's a less functional, but no one can really tell that the Android is the right way to go when designing something for humans, and market for that matter.
19. Aeires (unregistered)
Hipsters, that is all.
24. AppleConspiracy (Posts: 637; Member since: 18 Oct 2011)
Who are hipsters?
43. Aeires (unregistered)
If you ask, you missed the point.
78. AppleConspiracy (Posts: 637; Member since: 18 Oct 2011)
That was rhetorical question. I'm checking your knowledge on hipsters, that is, your knowledge of what actually makes someone a hipster. And?
86. Aeires (unregistered)
Not falling for that bait, we both know you can't easily hang a definition on "hipster."
Here's what I see, this articles underlying theme is stop the OS wars. Well, easier said than done because the tech sites created a monster they can't really control without much work and negative repercussions.
When the iPhone was released, there appeared a large group of people who thought they were instantly better than everyone else because they owned Apple's new toy. Tech sites ignored them constantly bashing Android users when that OS appeared. Days, weeks, and months turned into years of abuse by the condescending iCrowd. Lag, POS, lipstick on a pig, fragmentation, DOA, and a wealth of other negative comments spewed at people just because they used a different type of phone. Tech sites let it go on, after all, Android users were a handful and page clicks were more important. A deep hatred festered.
Then it happened, suddenly this ridiculed crowd became the majority. And Apple started to falter with their mistakes ("you're holding it wrong"), giving the new majority a wealth of ammunition. Years of abuse turned into hatred and they lashed back. Now there's a major, unnecessary OS war that gets fought on tech sites. To stop it they'd have to ban people (which they should have done after the iCrowd acted the way they did) but that would hurt page clicks so they are left in a bad spot.
It's not about fashion, everyone knows people bought the original iPhone because they thought it had the cool factor. Hollywood bought into it, thereby making a ton of people want it for no other reason than that. We've know for ages the iPhone is more of a fashion statement than a piece of hardware, it's nothing new.
People don't hate Apple for that, they hate them for the way their customers act, and they still act that way every day. It's not about fashion, it's about how people have been treated.
Before Apple made the iPhone, people got along much better on tech sites.
92. AppleConspiracy (Posts: 637; Member since: 18 Oct 2011)
It's all a story about Apple, but it's only a part of bigger picture. Apple phenomenon showed us the true nature of our system of values and its underlying mechanisms. Before Apple, the World was hidden from itself, concealed by empty ideologies that supposedly constituted our society. But now, we know the truth. The only thing you were actually wrong about in your comment is that you don't want to accept this truth.
Apple is a religion, it's not a brand, be it fashion or technical.
And this religion created its contra-religions. This has nothing to do with actual people being greedy.
And for the hipster part: I would say I know the correct definition very well ;-)
100. Aeires (unregistered)
You give too much credit to Apple, and that I can accept as truth.
22. weinerslav (Posts: 126; Member since: 31 Jul 2012)
This article is a bit... weird! "all of the Apple haters: consider how you think about fashion" this is not a linear matter, I am a fashionable person (discreet, don't really like to dress as a peacock) and I would never buy apple because of the company ethics, it depends more on who you are, than anything else! Meanwhile, since I would never buy the iphone, I had the original Prada, the Armani phone as secondary phones and now I have the Prada 3.0 as main phone, so like in real fashion you can pick always an alternative, and believe me, you don't wanna be seen in the streets with someone wearing the same clothes you're using, the same goes with phones for me, and I'd imagine most of the fashion conscious persons, I always had the most original phones I could find, and I'm sorry, you'd need to be very disconnected about this matter to believe that trends and fashion is the same, the iphone is a nice phone, but it's a trend and trends are like old fashion, fashion is what comes next, or at least if you have a visual identity that can stand against what came next, witch in case of men is far easy than for women...
30. MichaelHeller (Posts: 2703; Member since: 26 May 2011)
Obviously, there are those who fall on all parts of the spectrum, and there are those who will care about fashion, but still not like Apple. Just trying to hit the general feelings.


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Windows Azure Cloud Services Concepts (Part 1)
- Posted: Feb 05, 2013 at 10:17AM
- 3 comments
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In this video we'll review some of the fundamental concepts in Windows Azure Cloud Services, including Cloud Service, roles, and scaling options, etc. And then, we'll scale out our "Hello World" service to multiple instances and publish the service to Windows Azure to see it run on the cloud!
Next episode:
Walkthrough of the Management Portal for Windows Azure Cloud Services
Oops, something didn't work.
I am using Azure Mobile Services and logging URL selections as they are made:
Q: if I want to get a total of clicks by particular URL would it be cheaper to
a: Just log all clicks and take the hit on storage (& calculate totals as needed)
b: Use a trigger to update a running total per URL
Lets say for argument that there are 10,000 unique URLS and that generally 5% are hit more than once per day (24 hours)
Is this a reasonable question to ask? is there an easy way that I can answer the question myself?
Thanks for your time!
Question, Using the scale out method do the VM's automaticly start load balancing?
@11111111: Yes. Your customers access your services via endpoints, and traffic will be distribute across your roles in a round-robin fashion.
Comments have been closed since this content was published more than 30 days ago, but if you'd like to continue the conversation, please create a new thread in our Forums, or Contact Us and let us know.

subset: commoncrawl


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LISBON - Both candidates for the county recorder position say improvements are needed at the office, and records could be more properly maintained.
During a candidate forum hosted by the Morning Journal and WKBN First-News/Fox 17/62 Wednesday evening, Republican Theresa Bosel and Democrat Brenda Dickey Myers addressed what they believe to be the biggest issue to tackle if elected to the position currently held by Democrat Craig Brown.
Bosel said efficiency is needed at the office located in the courthouse and that efficiency would help foster a relationship with Chesapeake Energy, the Oklahoma-based oil and gas company that already owns the mineral rights to thousands of acres of county land.
The company has previously complained about the turn-around time on oil and gas records, and even put money toward digitizing some records in order to help alleviate the amount of traffic in the courthouse.
The records were digitized following Brown's request to county commissioners, who approved after some deliberation. The process was paid for through funds from Chesapeake and a $100,000 interest-free state loan.
Bosel said there is still a "high amount of traffic" there despite the records being digitized.
"Even though the records are digitized there are ways to make it (the office) more efficient," she said.
Dickey Myers also said the thousands of oil and gas leases aren't recorded in a timely manner, creating a backflow and making it difficult to research.
She added that an inventory of records is needed and that some are in poor condition and even missing pages.
She also said that if elected she would work to bring direction to the office and improve employee morale, which she said is currently low.
She believes her 28 years of experience in farming and being a small business owner makes her the right candidate for the position.
A Salem resident, she was most recently an administrator/sales representative for 21st Century Alarm/Data in Salem. She has also previously worked as an administrator for the Mahoning County Soil and Water Conservation District.
Bosel said that if elected she will "be a good steward of your money" and work on the "revenue issues" in the county.
She believes the county will benefit from the oil and gas boom and she said she will work closely with Chesapeake Energy to see those benefits realized.
Her experience includes 12 years in contract and budget management. She lives in Salem.
The recorder term is four years.


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Kevin Bingle
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Courtesy of Parker Pennington
Courtesy of Garth's Auctioneers & Appraisers
Dreams on Ice
It's two minutes to show time, and the little girl in white figure
skates looks terrified. Parker Pennington — the only skater to ever
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he was 3.
The youngster smiles and skates through the open curtain to the applause of her friends, family and the public.
For the past two years, Pennington has shared his love of ice skating
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producer of Skate Dance Dream, a variety show that pairs youngsters with
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"I ask kids why they started skating and to remember how much they enjoy
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experience, skills and number of young skaters and dancers.
"This is their moment," says Pennington. "We hope to see kids here who want to become elite dancers or go on to the Olympics."
But that's just part of it.
"Competition will always be there for some of these kids," he adds.
"Skate Dance Dream is sheer fun and it reinforces why they have been
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heroes. We are here to inspire."
Since its founding, Parker Pennington Productions has held Ohio shows in
Mentor, Gates Mills and Wooster. Next stop: The Clinton Arena in
Clinton, New York, on Dec. 8.
Pennington envisions taking his ice and dance extravaganza nationally
and even globally. "But right now," he says, "it's one glide at a time."
Visit SkateDanceDream.com for more information.
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Jefferson Davis becomes the president of the Confederacy, Pluto is discovered, a cow flies, the first Church of Scientology is formed, the Chicago Seven are found not guilty, and Dale Earnhardt dies at the Daytona 500, all on this day.
On this day: February 18UPDATED 1:00 AM CST Feb 18, 2016
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Internet that constantly cuts itself.
"Sorry I didn't reply to your e-mail last night, my emonet was acting up."
por Sekuna 08 de Outubro de 2007
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Can you define these popular missing words?
a man who has been known to paint lyrical masterpieces
Damn, is that Emonet paintin them lyrical masterpieces again? his rhymes are dank!
por The Keeper of the Moral Highground 04 de Junho de 2007


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HST in Ontario: Helping Business Grow
On July 1st, 2010, the Harmonized Sales Tax (HST) came into effect in Ontario and changed the way your business collects and reports taxes. But did you know that these changes to Ontario's tax system can help you grow your business?
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Your business can take advantage of the new tax rates for capital investments under the HST. By having lower tax rates, you can save money on purchases of new equipment and use the savings to invest in growing your business.
Some of the other changes to Ontario's tax rates include:
- The general Corporate Income Tax is now 12% (previously 14%)
- The Corporate Income Tax for manufacturing and processing is now 10% (previously 12%)
- The small business Corporate Income Tax rate is now 4.5% (previously 5.5%)
- The small business deduction surtax was eliminated
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To learn more about tax and business programs, you can attend one of the Ministry of Revenue's Tax Information Forums or visit the Taxes section of our website.
When will the Ontario government get on the same page as the federal government? I went to register for the spring seminar but was given the options to register for seminars on October 26, 2010 in Kitchener and November 2, 2010 in Hamilton. Go figure.
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Bruce A. Beutler, M.D., and Jules A. Hoffmann, Ph.D. share the prize for research into the innate immune system and Jules A. Hoffmann, Ph.D., wins for revealing the role of dendritic cells. [© Elnur - Fotolia.com]
The 2011 Nobel Prize in Physiology or Medicine shall be divided, with one half jointly to Bruce A. Beutler, M.D., and Jules A. Hoffmann, Ph.D., for their discoveries concerning the activation of innate immunity and the other half to Ralph M. Steinman, M.D., for his discovery of the dendritic cell and its role in adaptive immunity.
Dr. Hoffmann made his pioneering discovery in 1996, when he and his co-workers investigated how fruit flies combat infections. They had access to flies with mutations in several different genes including Toll, a gene previously found to be involved in embryonal development by Christiane Nüsslein-Volhard (Nobel Prize 1995).
When Dr. Hoffmann infected his fruit flies with bacteria or fungi, he discovered that Toll mutants died because they could not mount an effective defense. He was also able to conclude that the product of the Toll gene was involved in sensing pathogenic microorganisms and Toll activation was needed for successful defense against them.
Dr. Beutler was searching for a receptor that could bind the bacterial product, lipopolysaccharide (LPS), which can cause septic shock. In 1998, Dr. Beutler and his colleagues discovered that mice resistant to LPS had a mutation in a gene that was quite similar to the Toll gene of the fruit fly.
This Toll-like receptor (TLR) turned out to be the elusive LPS receptor. When it binds LPS, signals are activated that cause inflammation and, when LPS doses are excessive, septic shock. These findings showed that mammals and fruit flies use similar molecules to activate innate immunity when encountering pathogenic microorganisms. The sensors of innate immunity had finally been discovered.
The discoveries of Dr. Hoffmann and Dr. Beutler triggered an explosion of research in innate immunity. About a dozen different TLRs have now been identified in humans and mice. Each one of them recognizes certain types of molecules common in microorganisms. Individuals with certain mutations in these receptors carry an increased risk of infections, while other genetic variants of TLR are associated with an increased risk for chronic inflammatory diseases.
Dr. Steinman discovered, in 1973, a new cell type that he called the dendritic cell. He speculated that it could be important in the immune system and went on to test whether dendritic cells could activate T cells, a cell type that has a key role in adaptive immunity and develops an immunologic memory against many different substances. In cell culture experiments he showed that the presence of dendritic cells resulted in vivid responses of T cells to such substances. Subsequent work by Dr. Steinman demonstrated that dendritic cells have a unique capacity to activate T cells.
Further studies by Dr. Steinman and other scientists went on to address the question of how the adaptive immune system decides whether or not it should be activated when encountering various substances. Signals arising from the innate immune response and sensed by dendritic cells were shown to control T cell activation. This makes it possible for the immune system to react toward pathogenic microorganisms while avoiding an attack on the body's own endogenous molecules.
The discoveries that are awarded the 2011 Nobel Prize made possible the development of new methods for preventing and treating disease, for instance with improved vaccines against infections and in attempts to stimulate the immune system to attack tumors. These discoveries also help us understand why the immune system can attack our own tissues, thus providing clues for novel treatment of inflammatory diseases.
Dr. Beutler was born in 1957 in Chicago. He received his M.D. from the University of Chicago in 1981 and worked as a scientist at Rockefeller University in New York and the University of Texas in Dallas, where he discovered the LPS receptor. Since 2000, he has been professor of genetics and immunology at The Scripps Research Institute in La Jolla, CA.
Dr. Hoffmann was born in Echternach, Luxembourg in 1941. He studied at the University of Strasbourg in France, where he obtained his Ph.D. in 1969. After postdoctoral training at the University of Marburg, Germany, he returned to Strasbourg, where he headed a research laboratory from 1974 to 2009. He has also served as director of the Institute for Molecular Cell Biology in Strasbourg and during 2007–2008 as president of the French National Academy of Sciences.
Dr. Steinman was born in 1943 in Montreal, where he studied biology and chemistry at McGill University. After studying medicine at Harvard Medical School in Boston, he received his M.D. in 1968. He has been affiliated with Rockefeller University since 1970, has been professor of immunology at this institution since 1988, and is also director of its Center for Immunology and Immune Diseases.
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quote: No your point in the argument is someone has challenged your amazing new iDevice. You make blanket statements such as the one I just quoted, without backing it up with any proof. Which apps do people simply want, that aren't available?
quote: And widgets aren't useful? That's probably because you've never had them in the iWorld. Weather, News, Email, SMS, Music, Movie Times, Sports Scores, System Tools, Toggles, are all vastly more efficiently accessed via a widget than opening an app for each one. How easy is it to toggle WiFi on the iPad? What about looking up weather? Email? etc. Gliding from screen to screen on the Android homescreen can answer all these questions without ever opening an app.
quote: One final argument before I finish. Storage space. iPads don't have anything other than what's built in. While testing the prime, I had 32GB on board, 32GB in a microSD, 32GB on a full SD, and finally 32GB on a usb stick. I didn't get a chance to test the usb port for portable hard drives, so I can't comment as to whether they work or not, but all together, that's 128GB of space to play with. You may argue that the iPad doesn't need all that, but have you heard of the new Retina display? How small do you think building textures for that resolution will be? On Android a decent game can take 500MB, easy.
quote: We get it, you love Apple. While their new iPad is a great device for sure, it's not vastly steps ahead of the competition. I'd reluctantly recommend it to people who want a media consumption appliance, where they are guided on how they can use it and don't have many options to veer from the path. While the GPU on the iPad may indeed be the fastest available, it has to be just to keep up with the experience of other tablets that have already been on the market for months. It's still a step behind in the actual number crunching department, plain and simple.
quote: I don't love Apple at all


text:
Top Definition
A guy takes a dump on a woman while she is covered by plastic wrap as part of a sex act. See also, "Hot Carl" and "Cold Carl."
লিখেছেন- Deuce 24 de সেপ্টেমবার de 2003
Trending Now
Can you define these popular missing words?
(n.) When a partners shits on you but you are protected by saran wrap.
Also see hot carl and cold carl.
She gave me a hot carl but I didn't have to shower afterwards.
লিখেছেন- Mango 2 de জানুয়ারি de 2003


text:
Learn more
The season opens with a new production of Madame Butterfly, perhaps the most beloved of all operas, which has not been staged here in more than ten years. Kelly Kaduce returns as Puccini's heartfelt heroine Cio-Cio-San, joined by Elizabeth DeShong as Suzuki and Brandon Jovanovich as Pinkerton. Antony Walker and Lee Blakeley make their Santa Fe debuts as conductor and stage director.
Performance dates: July 2, 7, 10, 16, 23; August 2, 9, 14, 20, 26
Composed by Giacomo Puccini
Sung in Italian
Act I
Benjamin Franklin Pinkerton, a Lieutenant in the United States Navy, is inspecting his new house, built on a hillside overlooking Nagasaki harbor. The marriage broker Goro has arranged for the house and for Pinkerton's marriage to the geisha Cio-Cio-San, who is also known as Madame Butterfly. Sharpless, the American consul, arrives for the ceremony and warns Pinkerton that Butterfly is taking the marriage very seriously; Pinkerton himself considers it something of a lark, although he is enchanted with Butterfly. She arrives with her friends and tells Pinkerton that she has renounced her religion for his sake. When Butterfly's relatives arrive, the wedding ceremony begins, but it is interrupted by her uncle, the Bonze, who curses her for having abandoned her religion. The family members depart, leaving Butterfly alone with Pinkerton. As night descends, they sing of their love and slowly enter their new house.
Act II
Scene 1: Three years have passed. Pinkerton departed long ago and Suzuki, Butterfly's maid, implores her to forget her American husband, but she refuses, having faith in his promise to return. Sharpless and Goro try to persuade Butterfly to marry the wealthy Prince Yamadori, but she refuses. Sharpless starts to read a letter from Pinkerton, which suggests that he may never return, but Butterfly rejects the implication, and shows Sharpless her son, Trouble, who was fathered by Pinkerton before his departure. The harbor cannon fires to announce the arrival of a foreign vessel, which Butterfly recognizes as the Abraham Lincoln, Pinkerton's ship. She and Suzuki strew flowers throughout the house; she dons her wedding gown and, with Suzuki and Trouble, awaits the arrival of her husband as the sun begins to set.
Scene 2: Butterfly has maintained her vigil the entire night. As dawn breaks, Suzuki persuades her to rest. Sharpless and Pinkerton arrive and Suzuki soon discovers that the woman with them is Pinkerton's new wife, Kate. Sharpless tells her that they want to ensure a good American upbringing for Trouble and he then reproaches Pinkerton for his heartlessness. The latter bids an anguished farewell to the site of his past happiness and leaves, unable to face his Japanese bride. Butterfly enters and, after the situation is explained to her, agrees to give up the child if Pinkerton will return in 30 minutes. She bids a last farewell to her son, then sends him away. She takes up the dagger with which her father committed hara-kiri and stabs herself, just as Pinkerton is arriving for his son.


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Reloading .380 auto
Ammunition, Gear, and Firearm Help
Handloading and Reloading
> Reloading .380 auto
December 6, 2012, 12:21 AM
Looking to reload .380 anyone have any preferences on powders and such?
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December 6, 2012, 12:32 AM
Any fast burning pistol powder will work just fine. I happen to prefer Bullseye, but I don't think it makes that much of a difference. As far as bullets go, stay under 100 grains. Heavier bullets can bulge the case and not chamber in some pistols.
December 6, 2012, 12:36 AM
Thanks someone else said that also about staying under 100gr bullets. I just bought 95gr rn for a cheap price so I plan on getting some powder this weekend. I have some power pistol but wanted to see what wimple have been using or what works better than another.
December 6, 2012, 12:43 AM
I size any cast boolits -commercial or my own. After loading a few, drop them into your chamber to insure everything is right. My Sig 232 is finicky with my loads but it is still new. The Colt gub style 380 chews them up fine. Used a bunch of Unique but have gone to ball powders lately. Unique clogs (bridges) sometimes and I have to really keep an eye on the powder levels. I weigh every 5th round's powder if there is any problem at all. Normally every 10th will do.
December 6, 2012, 12:49 AM
I just bought 95gr rn for a cheap price
Soo what are they?
Hawks recommendation of Bullseye is a good one, as is W231 and Accurate #2,
Power Pistol will likely give the most velocity, but it is a bit hot for cast bullets.
December 6, 2012, 02:44 AM
I like 3.0gr 231/hp38 under a 102 gr cast boolit. gives you that factory feel with handloads out of a tiny plastic gun. sucker tries to jump straight up out of your hand, but its still accurate to boot.
December 6, 2012, 08:14 AM
I have loaded some 110 JHP in 380 ACP. Worked fine in my Beretta M84 but velocity probably would not be fast enough to expand.
I regularly used cast Lee 105 SWC when I was casting bullets. These were great. (I need to break out my casting equipment and try these in my micro 380s)
Currently, I am loading 700-X in the 380 ACP because I have it on hand for 45 ACP. I have used a number of other powders over the years.
Currently, I load 90-100 grain FMJ bullets depending on what I find for a good price.
December 6, 2012, 08:23 AM
I've had very good results using Accurate Arms AA#2 powder in .380. Gives me more consistent velocity than any other powder I've tested. Haven't tried Bullseye though.
December 6, 2012, 08:27 AM
Just started loading .380 auto and so far only with W231. Good results, but Lyman 49 starting charges for W231 seem very light. I'll notch up my next batch.
December 6, 2012, 09:38 AM
I like the Berry's 100 grain HBRN and 3.0 grains of Bullseye. I have also had successful loads using Power Pistol. I'd like to try Titegroup but that requires so little powder that I don't have a disk small enough for my powder measure.
95 grain fmj's also work well with 3.0 of Bullseye for me.
Good Luck.
December 6, 2012, 09:53 AM
I've been using 2.8gr of Bullseye with anything from 88gr JHP, 90gr JHP, or 95gr FMJ or 100gr Berrys RNFB or MBC 95gr LRN. It just works well in LCP, P238, and Colt Mustang. W231 works well too with around 3.2gr.
December 6, 2012, 11:47 AM
2gn & under of bullseye doesn't meter will through my disk so I switched to Red Dot.
December 6, 2012, 12:56 PM
I like 3.3 gr of 231 with 90gr Gold Dots or 95gr cast. It's a hair over the 3.2 Lyman charge but it works well in my PA63.
December 6, 2012, 01:28 PM
I have used Bullseye and Powerpistol in the past but the best load I have so far is 3.0grains VV-N310 and 95gr.FMJ. Velocity is about 1000fps. Clean, accurate and consistent.
December 6, 2012, 04:14 PM
Another vote for 100 gr lead with 3.2 of W231. My Bersa .380 eats them up and the recoil is nice and easy. Plenty accurate too.
December 6, 2012, 08:33 PM
I use 2.8-3.0 gr of 231 under a 95gr bullet. Same charge for lead or FMJ. It's pretty light, but that's why my wife likes to shoot in the LCP.
December 6, 2012, 09:50 PM
a) Small 380 pistols with light weight slides, thin chamber wall, .257" poor case support, short 2.75" barrel, and wimpy springs, I am lucky to get 1100 fps 90gr Gold Dot.
b) A big 380 with heavy slide, thick chamber wall, that will feed a 1.09" cartridge, case support to the web, long 5" barrel, and big recoil spring space, I can get 1187 fps 158 gr XTP.
c) Then I have some 380 pistols with medium weight slide, medium case support, that I get performance with Win 115 gr JHP I get power some where in between.
But in all cases, I use Power Pistol.
December 6, 2012, 10:06 PM
AA #2 is really good, but I've also used AA #5 with good results. As mentioned by several folks, keep the bullet weight at 90 - 95 gr and they should perform very well. I've had good results with Berry's and Montana.
December 6, 2012, 10:11 PM
Put me in with the guys using 231. I use a cast 95gr RNL and 3.2 gr of 231 in mixed brass. Works really well in all three of my autos, a Bersa, and two Taurus: a PT638 and TCP738. Accurate and reliable in all three.
December 7, 2012, 01:43 AM
AutoComp is an easy powder to work with for .380. It will operate at significantly lower pressures while delivering higher velocities if desired. Even at max charges it operates about 1,000 cup below the other powders with a 95 gr. jacketed bullet. It's also not going to be as charge sensitive as the faster burner's are, because it has a larger pressure spread, about 2,000 cup from minimum to maximum, and a larger charge range to work with too. This makes it less sensitive to work up increments.
December 7, 2012, 02:52 PM
Soo what are they?
Hawks recommendation of Bullseye is a good one, as is W231 and Accurate #2,
Power Pistol will likely give the most velocity, but it is a bit hot for cast bullets.
I bought a bag of 250 for 12.00 but there Winchester 95gr fmj
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Top Definition
Foolage is the the doing of something foolish, And using the power of the internet, we add age instead of ish. Foolage is also the name of the website Foolage.com, Home to Animal Crossing-Inspired Videos and comics, Amongst many other things.
Replace I am sick of all this foolishness; with I am sick of all this Foolage!
بواسطة Captain Foolage مايو/أيار 25, 2007
Trending Now
Can you define these popular missing words?
The poofy shit under wedding dresses... ie not a bush, but foolage
That dress has too much foolage... it makes my ass look big!
بواسطة Mamie يونيو/حَزيران 12, 2003


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Beautiful Apartment in City Centre
Størrelse65 m²
Etage(med elevator)
- Familie/børnevenlig
- Køkken
- Vaskemaskine / tørretumbler
- Elevator i bygningen
- Internet/WIFI
- Opvaskemaskine
- Håndklæder
|Postgasse, 1010 Wien, Østrig
|Inden for få timer
|Kalenderen er opdateret
|I dag
First district (1010 Wien): 5 minutes walking distance to the Stephans Cathedral, Graben and Kaertnerstrasse. Excellent public transport connection: Underground station U4 and U1 "Schwedenplatz" and tram station 1, 2 in 100 m distance from the apartment. Airport bus shuttle (20 min to the airport, every 30 minutes, 7 euro one way) stops at Morzinplatz in 400 m distance from the apartment.
Restaurants & Bars, Fast food stores, Bakery and Butcher, Supermarkets, Post office, Dry cleaner and the shopping high streets Kärtnerstraße and Graben are all in walking distance!
The apartment is fully renovated in december 2011. It includes:
- Entrance hall: wardrobe, chair
- Kitchen: Breakfast table with two stools, Refrigerator, Dish-washer, Water Boiler, Dishes and Cutlery, Pots & Pans as well as other cooking facilities.
- Toilet: WC with hygiene shower, small washing basin, Washing machine and dryer.
- Bathroom: Shower, big washing basin, cupboard
- 2 Bedrooms: Queen size bed, Wardrobe, bed side tables
- Living room: Sofa, dining table for four persone, which can be enlarged, shelves, TV (with german and international channels).
Wireless internet is provided in the whole apartment !
Check-in / Check-out:
As you can see from the details, I am flexible with the check-in and check-out times. We will set an appointment for your check-in and check-out up in front. Me or my very good friend, or the cleaning lady will meet you at the apartment, give you the keys and explain everything you have to know about the apartment and the area.
When you book, you will get my contact details including my mobile number and my email, on which you will be able to reach me anytime.
Please note that late check-in after 21:30 (9:30pm) and early check-in before 09:00 (9am) is subject to an additional fee of 5€.
Also you have the possibility to rent a baby cot and/or baby feeding chair. Price upon request.
I also offer pickup options for my guests from airport and train stations. Please message me for further information.
For further information don't hesitate to contact me :)
Please be informed that the regulations for the city charges in Vienna have changed and therefore we are obliged by law to collect a city tax from the 1st of May 2016 from our guests.
We will need to charge 2,4584% of your accommodation costs including the cleaning fee.
Unfortunately the tax cannot be collected directly over Wimdu and therefore needs to be paid at the check-in in cash. Please be so kind and prepare the amount accurate to the cent.
You will certainly receive a receipt fort the city tax at the check-in.
We know that this whole procedure is a bit inconvenient, however we are required by law to proceed this way.
We thank you for your understanding and collaboration.
Best regards,
Anna & Vladan
|Check-in efter
|Efter aftale
|Check-in før
|Efter aftale
|Check ud før
|Efter aftale
It's a cozy and clean apartment. But the main point is that it's right in the city centre.
Stephans Platz is a few minutes walk away and you can easily reach Ofburg by feet.
Beautiful appartment. Really good place. Near from everything.
It was clean. Located in an old renoved buiding.
For sur an ideal weekend.
Visitng Wien was very pleasure thanks to Wien and this appartment....
It was a perfect flate in a ideal localitation.
I recomed to everyone
the apartment was very good. it was very clean on our arrival. it had all the essentials of a comfortable stay. anna was a very helpful host. when we came, she was waiting at the apartment for us and showed us everything. we enjoyed our stay a lot. would highly recommend it to everyone.
great apartment in the very center of Vienna. very spacious and comfortable in a 17° century building : a very peaceful place where relax for a while. only a small suggestion: another higher hook in the shower could be useful !
thenk you Anna & Vladan
I had a wonderful stay in Vienna at Anna & Vladan's apartment. The apartment was neat, spacious and in the middle of the city center near the Opera and the Stephansdom which was superbe. I will definitely stay here again and can recommend the apartment to young couples as well as friends or families visiting Vienna!
We stayed for 2 nights with a family of 2 parents and three adolescents. 2 bedrooms and 1 sleepingcouch in the living room. The appartment is situated in the heart of Vienna at a small cosy square.
Reception and key exchange was easy and went perfectly well. Short introduction of the appartment and some touristic tips on Vienna were provided.
Apartment was very clean and stylish.
Kids loved the WIFI. :-)
One minor setback was that no washing machine was available.
great location & most charming and gentle hosts!
Anna and Vladan helped us to have a nice day in Wien. We were in a urgency and they were very understanding and helpful. They even helped us to carry and keep the suitcase. Not to forget that they offer a new, perfect located apartment.
Perfect location 5 minutes walking from stephansplatz. Very nice and quite apartment with comfortable beds. Clean sheets and towels. Very strong wifi and cable TV. In the apartment you will find printed helpful information for the apartment and generally for Vienna. Really professional hosting from Anna and Vladan. HIGHLY recommended to everyone who travel to Vienna.
- Kvalitetssikrede boliger
- Alle værter verificeres via telefon
- Sikker betaling med SSL-kryptering


text:
Adapting to Evolving Business Environments Is...
As Immunotherapy Revolutionizes the Cancer Treatment...
Wall Street Decline Takes Its Toll...
LC-MS Gains Favor Due To the...
Biomarkers by definition indicate some state or process that generally occurs at a spatial or temporal distance from the marker itself, and it would not be an exaggeration to say that biomedicine has become infatuated with them: Where to find them, when they may appear, what form they may take, and how they can be used to diagnose a condition or predict whether a therapy may be successful.
Biomarkers are on the agenda of many if not most industry gatherings, and in cases such as Oxford Global's recent "Biomarker Congress" and the GTC "Biomarker Summit", they hold the naming rights. There, some basic principles were built upon, amended, and sometimes challenged.
In oncology, for example, biomarker discovery is often predicated on the premise that proteins shed from a tumor will traverse to and persist in, and be detectable in, the circulation. By quantifying these proteins—singularly or as part of a larger "signature"—the hope is to garner information about the molecular characteristics of the cancer that will help with cancer detection and personalization of the treatment strategy.
Yet this approach has not yet turned into the panacea that was hoped for. Bottlenecks exist in affinity reagent development, platform reproducibility, and sensitivity. There is also a dearth of understanding of some of the fundamental principles of biomarker biology that we need to know the answers to, said Parag Mallick, Ph.D., whose lab at Stanford University is "working on trying to understand where biomarkers come from." And sometimes, too, accepted wisdom just isn't so.
For example, there are dogmas saying that circulating biomarkers come solely from secreted proteins. But Dr. Mallick's studies indicate that fully 50% of circulating proteins may come from intracellular sources or proteins that are annotated as such. "Right now we don't understand the processes governing which tumor-derived proteins end up in the blood."
Other seemingly obvious questions include "how does the size of a tumor affect how much of a given protein will be in the blood?"—perhaps the tumor is necrotic at the center, or it's hypervascular or hypovascular. "The problem is that these are highly nonlinear processes at work, and there is a large number of factors that might affect the answer to that very simple question," he pointed out.
Their research focuses on using mass spectrometry and computational analysis to characterize the biophysical properties of the circulating proteome, and relate these to measurements made of the tumor itself.
"We've observed that the proteins that are likely to first show up and persist in the circulation, on average, are more stable than proteins that don't," Dr. Mallick said. "This is something that people qualitatively suspected, but now we can quantify how significant the effect is."
The goal is ultimately to be able to build rigorous, formal mathematical models that will allow something measured in the blood to be tied back to the molecular biology taking place in the tumor. And conversely, to use those models to predict from a tumor forward to what will be found in the circulation. "Ultimately, the models will allow you to connect the dots between what you measure in the blood and the biology of the tumor."
Affinity reagents are the main tools for large-scale protein biomarker discovery. And while this has tended to mean antibodies (or their derivatives), other affinity reagents are demanding a place in the toolbox.
Among these are Affimers, a type of affinity reagent being developed by Avacta. Affimers consist of a biologically inert, biophysically stable protein scaffold containing three variable regions into which distinct peptides are inserted. The resulting three-dimensional surface formed by these peptides interacts and binds to proteins and other molecules in solution, much like the antigen-binding site of antibodies.
Unlike antibodies, Affimers are relatively small (13 KDa), non-post-translationally modified proteins that can readily be expressed in bacterial culture. They may be made to bind surfaces through unique residues engineered onto the opposite face of the Affimer, allowing the binding site to be exposed to the target in solution. "We don't seem to see in what we've done so far any real loss of activity or functionality of Affimers when bound to surfaces—they're very robust," said CEO Alastair Smith, Ph.D.
Avacta is taking advantage of this stability and its large libraries of Affimers to develop very large affinity microarrays for drug and biomarker discovery. To date they have printed arrays with around 20–25,000 features, and Dr. Smith is "sure that we can get toward about 50,000 on a slide," he said. "There's no real impediment to us doing that other than us expressing the proteins and getting on with it."
Customers will be provided with these large, complex "naïve" discovery arrays, readable with standard equipment. The plan is for the company to then "support our customers by providing smaller, bespoke, arrays with the Affimers that are binding targets of interest to them," Dr. Smith foretold. And since the intellectual property rights are unencumbered, Affimers in those arrays can be licensed to the end users to develop diagnostics that can be validated as time goes on.
Around 20,000-Affimer discovery arrays were recently tested by collaborator Professor Ann Morgan of the University of Leeds with pools of unfractionated serum from patients with symptoms of inflammatory disease. The arrays "rediscovered" elevated C-reactive protein (CRP, the clinical gold standard marker) as well as uncovered an additional 22 candidate biomarkers. Some of the latter, when combined with CRP, appear able to distinguish between different diseases such as rheumatoid arthritis, psoriatic arthritis, SLE, or giant cell arteritis.
Sometimes biomarkers are used not to find disease but to distinguish healthy human cell types, with perhaps the most obvious examples being found in flow cytometry and immunohistochemistry. These widespread applications, however, are difficult to standardize, being subject to arbitrary or subjective gating protocols and other imprecise criteria.
Epiontis instead uses an epigenetic approach. "What we need is a unique marker that is demethylated only in one cell type and methylated in all the other cell types," explained CBO and founder Ulrich Hoffmueller, Ph.D. Each cell of the right cell type will have two demethylated copies of a certain gene locus, allowing them to be enumerated by quantitative PCR.
The biggest challenge is finding that unique epigenetic marker. To do so they look through the literature for proteins and genes described as playing a role in the cell type's biology, and then look at the methylation patterns to see if one can be used as a marker, Dr. Hoffmueller said. They also "use customized Affymetrix chips to look at the differential epigenetic status of different cell types on a genomewide scale."
The company currently has a panel of 12 assays for 12 immune cell types. Among these is an assay for regulatory T (Treg) cells that queries the Foxp3 gene—which is uniquely demethylated in Treg even though it is transiently expressed in activated T cells of other subtypes. Also assayed are Th17 cells, "which are especially tricky to detect by flow cytometry because the cells have to be stimulated in vitro," he pointed out.
Researchers at Myriad RBM and the Cancer Prevention Research Institute of Texas are collaborating to develop new assays for cancer biomarkers on the Myriad RBM Multi-Analyte Profile (MAP) platform.
The release of OncologyMAP 2.0 expanded Myriad RBM's biomarker menu to over 250 analytes, which can be measured from a small single sample, according to the company. Using this menu, L. Stephen et al., published a poster, "Analysis of Protein Biomarkers in Prostate and Colorectal Tumor Lysates," which showed the results of a survey of proteins relevant to colorectal (CRC) and prostate (PC) tumors to identify potential proteins of interest for cancer research.
The study looked at CRC and PC tumor lysates and found that 102 of the 115 proteins showed levels above the lower limit of quantification. Four markers were significantly higher in PC and 10 were greater in CRC. For most of the analytes, duplicate sections of the tumor were similar, although some analytes did show differences. In four of the CRC analytes, tumor number four showed differences for CEA and tumor number 2 for uPA.
Thirty analytes were shown to be different in CRC tumor compared to its adjacent tissue. Ten of the analytes were higher in adjacent tissue compared to CRC. Eighteen of the markers examined demonstrated significant correlations of CRC tumor concentration to serum levels.
"This suggests that they would be good protein markers to follow changes in tumor levels," reported the researchers, who added that the Oncology MAP 2.0 platform "provides a good method for studying changes in tumor levels because many proteins can be assessed with a very small sample."
Circulating proteins provide a wealth of potentially useful information that can be used for clinically relevant diagnostic tests. While there have been many attempts to translate results from early discovery work on the serum proteome into clinical practice, few of these efforts have progressed past the discovery phase.
Matrix-assisted laser desorption/ionization-time of flight (MALDI-ToF) mass spectrometry on unfractionated serum/plasma samples offers many practical advantages over alternative techniques, and does not require a shift from discovery to development and commercialization platforms. While MALDI still has had some hurdles to overcome, Biodesix claims it has been able to develop the technology into a reproducible, high-throughput tool to routinely measure protein abundance from serum/plasma samples.
"In our approach to develop tests, we improved data-analysis algorithms to reproducibly obtain quantitative measurements of relative protein abundance from MALDI-ToF mass spectra. These measurements are combined with clinical outcome data using modern learning theory techniques to define specific disease states based on a patient's serum protein content," says Heinrich Röder, CTO.
The clinical utility of the identification of these disease states can be investigated through a retrospective analysis of differing sample sets. For example, Biodesix clinically validated its first commercialized serum proteomic test, VeriStrat®, in 85 different retrospective sample sets. "It is becoming increasingly clear that the patients whose serum is characterized as VeriStrat Poor show consistently poor outcomes irrespective of tumor type, histology, or molecular tumor characteristics," Röder adds.
MALDI-ToF mass spectrometry, in its standard implementation, allows for the observation of around 100 mostly high-abundant serum proteins. "While this does not limit the usefulness of tests developed from differential expression of these proteins, the discovery potential would be greatly enhanced if we could probe deeper into the proteome while not giving up the advantages of the MALDI-ToF approach," he explains.
Biodesix reports that its new MALDI approach, Deep MALDI™, can perform simultaneous quantitative measurement of more than 1,000 serum protein features (or peaks) from 10 µL of serum in a high-throughput manner. The technology increases the observable signal noise ratio from a few hundred to over 50,000, resulting in the observation of many lower-abundance serum proteins.
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text:
Library Book Sale!
- When:
- Location:
- Langsdale Library
- Room:
- Auditorium
- Description:
Langsdale's Book Sale
Langsdale Library at the University of Baltimore is having a book sale!
The annual Langsdale Book Sale will take place on Wednesday, Oct. 30, from noon-8 p.m. and Thursday, Oct. 31, from 9 a.m.-1 p.m.
On Wednesday, hard-cover books will be $2.00, paperback books will be $0.75, mass-market paperbacks $0.25, and video/audio materials will be $1.00.
On Thursday, for $1.00: all you can carry.
The sale will be held in the Langsdale Auditorium, 1420 Maryland Ave.
Get there early for the best selection.
- Contact Name:
- Adam Shutz
- Contact Email:
- firstname.lastname@example.com
- Contact Phone:
- 410.837.4290


text:
Top Definition
One of the names preferred by people in the Andean countries who speak Runasimi or Aymara. The name "cholo" is also used but seems to cause some confusion if it is directed at a speaker of Aymara. One of the other names, "indio", is a derogatory epithet and should NEVER be used when speaking to a Quechua- or Aymara-speaking person.
Carlos is a campesino, from the altiplano in Bolivia. He speaks both Quechua and Aymara.
de pentozali 15 octobre 2007
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text:
|Never Heard of an AFCI?
|| Print |
Never heard of an AFCI? It may save your home someday!
"I want the new picture right there, dear." And with those instructions, you begin hanging a large framed picture above the sofa. Because of its size and weight, you use a large nail, find the stud, and begin to pound.
But hidden behind the wallboard was a wire that provided electricity to an outlet behind the sofa. Your nail pierced the wall, clipped the edge of the stud, and poked deep into the wire, tearing the insulation and shorting the electrical circuit to the living room. The wall soon became hot, you smelled smoke, and fire erupted behind the wall. Down fell the new picture you just hung. Never mind the picture and frame were destroyed, your house was on fire.
Hours later the fire inspector finds you sifting through the remains of your home and asks what you might know about the start of the fire. Taking notes, he writes, "Hanging picture, nail through the wall," and he stops to ask if you had an arc fault circuit interrupter. Since you have never heard of one, he says an AFCI would have saved your home. For fewer than 50 dollars, it would have detected the damaged wire behind the wall, cut the power to the circuit, and you would be living in your home, instead of at your in-laws.
The wires in your home keep electricity on a set path. When those wires are damaged or decaying, electricity can veer out of wires and off that designated path. When this happens, an arc fault occurs, and electricity is discharged behind the wall. The electricity heats up, and eventually starts a fire. Arc faults cause many of the 28,000 electrical fires in homes every year. Fortunately, an AFCI can prevent this.
The AFCI monitors electricity in your home. It can detect if something is wrong, and shut electricity off before it has time to heat up and start a fire. An AFCI costs around $35 and can be installed by a qualified electrician. The cost of installing AFCIs will depend on the size of your home and number of circuits. Just like fire alarms, carbon dioxide detectors and locks, AFCIs are an important investment in the safety of your home.


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Top Definition
When you are walking in front of a car and the driver revs the engine loudly in order to get your attention or let you know he has noticed how sexy you look.
1) "Haha, I just got vroomed walking here..."
2) "That person just vroomed at me."
2) "That person just vroomed at me."
de MyPieCreations 29 juillet 2010
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text:
|Welcome to the MANGA Forum.
|You will have to register before you can post: log in or sign up at the top of the page to proceed. To start viewing messages, select the forum that you want to visit from the selection below.
has anybody ever read this before?
which alice book you meant?Alice in wonderland by CLAMP?Alice gakouen?or just Alice in Wonderland... O genki desu ka?
Alice Cooper? Alice in Chains?Alice .. ummmm. damn, I ran out of Alice's. 92% of the teenage population would be dead if Ambercrombie and Fitch or Hollister said it was uncool to breathe.
it's just called alice.it's about this girl that learns to have courage.
ooo, Alice 19th? by the same author ofFushigi Yuugi? yup read it... pretty good, shame there's no anime version of it O genki desu ka?
yea thatsit!i forgot about the 19th part.i love that book.im just finishing the first though.
The path to conquest leaves nothing else to be desired!!!!
yeah ive read the whole series it only took me a week life sucks GET OVER IT


text: Polonius discusses the cause of Hamlet's madness with the King and Queen, and shows them letters which Hamlet has written to Ophelia. (II.ii.) Gertrude: Joy Lafleur; Polonius: William Hutt; Claudius: Douglas Campbell; Michael Langham - Director; Desmond Heeley-Costume Designer. http://www.clevelandmemory.org/copyright/; Cleveland State University. Michael Schwartz Library. Special Collections. Repository Homepage http://web.ulib.csuohio.edu/SpecColl/


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When The Bureau was first announced, fans of the series were pissed: "Excuse me, kind sir," they would politely say. "That doesn't look like an XCOM game." The series had abandoned its roots in the eyes of the verbal - and then XCOM: Enemy Unknown was released. People forgot about 'that weird FPS' that seemed to sit so uncomfortably within the universe... for a while.
The next time we saw it, the game had evolved into a third-person squad shooter. The first batch of screens admittedly weren't very exciting and it seemed poised to just fill the gap between Enemy Unknown and its inevitable sequel - it looked like it was being sent out to die.
Luckily, that's not the case. The Bureau is a reimagining of XCOM canon - again - twisting the invasion narrative to fit the story viewed from a single protagonist, William Carter. A man tasked with stopping the invasion on American soil, in contrast with Enemy Unknown's global struggle.
The Bureau tells its tale - for the most part - through overheard conversations, notes and audio recordings. Obviously this is nothing new - especially for 2K Marin - but the execution is excellent. One of these moments stood out for me. It happened in between skirmishes, when I stumbled across a dead body and a treehouse. There was a note on the body, explaining that she had been protecting her daughter from the invaders - placing her in the safety of the treehouse. All you can do is look up, trying to see between the cracks in the slats of the wooden platform. Is she in there? Is she dead?
There are lots of little moments like this, and I'm sure I didn't see them all, but they all flesh out the story nicely. It still feels like XCOM, but this time the tone is more personal. The experience is like bathing in a massive vat of mutated lore. Each body tells a story if you care to look. And I won't spoil the surprise, but later the tale goes from mildly intriguing to massively captivating - and it all happens rather fast. The Bureau has a lot to say.
That's not to say the story is perfect - they rarely are - as there's the odd plot hole where you just have to suspend your disbelief and go with it. For instance, there are infected people, called sleepwalkers. They play out the last thing they remember over and over like an organic vinyl record. How they don't starve to death is a complete mystery.
Overall, the narrative works well, with player choice and multiple endings being the icing on this delicious cake. It's in the decisions where the similarities with its strategy sibling begin to become apparent. Outside of the narrative choices, there are decisions in both battle and preparation. For one, naming your soldiers is back, and so is the guilt you feel when they die.
When you've finished making your squad look like Teletubbies, though, you can take them into your not-so-covert ops, where they'll hopefully not die. As mentioned, because the story takes place in the '60s, the XCOM agency is in its infancy, thus you'll only have to battle to save American lives. There's still a war map, and you can choose from a selection of operations - even sending units out on field ops, increasing their skills but rendering them unavailable for the next mission. If all your agents die, you lose...
Most missions play out in the same way, just as they do in XCOM: Enemy Unknown. You'll come up on a group of hostiles, who are usually unaware if you sprint straight into cover, which is indicated with a full and half shield - signifying the benefit of the cover. After this you'll send each member of your squad to a position, spreading out your firing lines and trying to take advantage of the extra damage inflicted by a flanking maneuver. Once in place, you unleash hell. Turrets are set up to provide extra firepower, mines are placed to cover blind spots, drones are sent airbound to flush the enemies from cover and a fire mission is called in to rain death on some clustered outsiders.
Abilities can even be combined - using Carter's Lift ability to raise a friendly turret above the battle, for instance - and enemies can be turned against one another. Tactically, it feels like there are more options than during Enemy Unknown's combat. To call it dumbed down, would lead to me accusing you of playing it on Easy. The only missing component that I cared about was the destruction. You won't be using cars to your advantage or blowing holes in walls here. Which is a shame, but we can always hope the game gets a sequel and the omission is amended.
Blowing up walls would be a handy tool in The Bureau, too, because - like XCOM - you're initially equipped to fight humans. The difference with The Bureau, is things escalate faster and you're up against bipedal Sectopods before you know it, with the early weapons causing scratch damage at best. There is that same tipping point, though, the one that you get in traditional XCOM games where your tech is improved, your soldiers are battle hardened and the scales tip in your favour. That's not to say it gets any easier, it's just that at around the same time, all the systems seem to click - a light turns on and all is clear, you're the master of the battlefield.
That's what makes The Bureau brilliant: it's a clever union of two genres. I went into the game not knowing what to expect, and I haven't been as surprised by the quality of a title in a long time. I hope people don't shrug the game off as being a cash-in, because it isn't. It's the full XCOM experience in its own right and it has lots of fan service. It even feels great to just wander around the facility between missions, looking at all the subtle differences and listening to the characters' plights. Yet the burning question remains: are Mutons still dicks? The answer is yes, yes they are.


text:
A man's saggy, wrinkly balls that hang low (sometimes below the knee). Best used for tea bagging.
"Goofy totally has Turkey Balls." or "Goofy sure has some nasty Turkey Balls." "OMG! I like totally just saw Mickey sucking on Goofy's turkey balls!"
автор: NuttersNutsack 29 июня 2013
Trending Now
Can you define these popular missing words?
Top Definition
When a man's nutsack looks like that thing that hangs from a turkey's neck
As Maria watched porn with her boyfriend she couldn't help but notice that one of the actors had turkey balls
автор: Coneja 7 июля 2009
(to turkey ball, verb):
To glare or stare at a person or group of people with rebuke, disdain, or disapproval.
To glare or stare at a person or group of people with rebuke, disdain, or disapproval.
Did you see that guy turkey balling me?
автор: thebmarinara 22 августа 2012
A large turkey-neck-looking device that is spun round in multiple rotations and then let go directed at an offender. They are usually made from some sort of hard object tied into old pantyhose and are recommended for use in attempting to slap your little brother with for being obese.
"ah stop being fat or i'll slap ya with my turkey ball!"
автор: umbie 21 марта 2004
A game of football you play on or the day after thanksgiving
Hey kevin me and the guys are gona play a game of turkey ball tomorrow morning, wanna come?
автор: footballa2gjdjdjd 27 ноября 2009


text:
Digester interest remains strong
Digester interest remains strong
by Hoard's Dairyman staff
This year's conference "Got Manure?" featured a preconference tour of three New York digester systems.
Methane digester interest continues to grow, as a near capacity crowd filled the conference room at the Holiday Inn, Liverpool, N.Y. AgStar, a joint initiative of USDA, EPA, and the Department of Energy, held its annual conference in partnership with New York's PRO-DAIRY program. Nearly 40 experts, be they farmers, researchers, or industry professionals, will speak today and tomorrow on their experiences, challenges, and mistakes with anaerobic digestion. The preconference tour featured three very different digester operations that we'll summarize below.
Cayuga County Soil and Water Conservation District
The first we visited was a community digester run by the Cayuga County Soil and Water Conservation District. This digester is in its infancy, just beginning to be filled with manure. Its manure is coming from two farms and 1,500 cows. Like the two other sites we visited, they were using substrates (additives to boost energy production) including food waste and brown fat.
The unique setup relies on trucking to get the manure to the plant from farms 7 to 12 miles away. The facility manager admitted this will be a challenge with spiking gas prices. Approximately 35,000 gallons of manure and 8,500 gallons of food waste will be trucked in daily once this digester is at full operation. The full cost of this project was $9.7 million.
Patterson Farms
The next site was on land owned by Patterson Farms. Their digester is run from their 950 lactating cows' manure and combined with food waste from milk processing plants. Previously, they also accepted potato starch water, culled onions, and corn syrup waste. Connie Patterson is the matriarch of this farm family, and she manages the operation with her son, Jon. The digester was constructed beginning in August 2004, with operation beginning in October 2005.
The total costs of this operation's digester was about $1.5 million. They said if they did it all again, they would definitely build the digester, but they would do many things differently – like listening to warnings and recommendations from people who already run digesters.
Synergy Biogas at Synergy Dairy
The final stop on our tour was the impressive Synergy Biogas site. The digester system there was built after the dairy was constructed. They turned flush-cleaned barns into scrape-cleaned barns for the purpose of the digester. Their 1,866 cows' manure fuels the digester system which is run by a totally separate company.
Synergy Biogas runs the site, including two 100,000-gallon receiving tanks and a 74- by 72-foot digester tank. The total cost of this digester was $7.75 million. Being separate companies, the dairy farm agrees to supply manure to the digester system, while they deliver separated solids back to the farm for bedding. The farm's somatic cell count ran at about 150,000. Eventually, the digester system hopes to also supply the farm's electricity.
For more on Cornell's digester case studies, click here.


text:
Reviewed By Steven H (WONDER LAKE, IL) Reviewed for a 2005 Chevy Malibu —11/18/2014 2:51 PM
The fit was superb. The lights look exactly as advertised. I give it one star less than perfect only because I think Spyder could do the homework and provide better vehicle specific wiring diagrams, but the product itself is wonderful.


text:
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Dress up your little Cowboys fan's backpack with this Creature Ball clip! This cute little guy will be the perfect Dallas-spirited companion for your youngster. A plastic lobster claw clasp is attached to the top of this football-shaped creature while embroidered accents are featured on the front for amusing Cowboys fun!
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text:
Sources: Europa [EU press releases], Reuters [Microsoft response]
quote: I do not believe in a completely free market, it does not work.
quote: If IE is so good why won't MS code it for other OS platforms ? as the majority are open source that shouldn't be much of a problem
quote: You're wasting my time.
quote: MS forced European PC manufacturers to NOT install another browser, if they wanted Windows. MS has no right to dictate what a customer should choose.
quote: The end game for you is to concoct some story about how the EU is attacking American capitalism. Anything less wont do.
quote: I checked your browser stats and found it was shite.
quote: No, I'm a Conservative . I believe in minimal Government, liberties and freedom , among other things.
quote: But, just curious, how exactly could Microsoft "force" PC manufacturers in Europe to do something? Perhaps 'force' was too strong a word.
quote: The customers want Windows so a PC maker could either chose to do what Microsoft demanded or see their customers become ex-customers.
quote: But I don't expect a European to understand these concepts.
quote: Reclaimer è la prova vivente che l'intelligenza artificiale non può competere con la stupidità naturale.
quote: It like there's one water company in a town that owns all the pipes, its too expensive for other companies to come because its a small town. so they won't give you water unless you take their electricity, Internet, mobile service and cable.
quote: This from a country with capital punishment and gun ownership. You guys believe in punishment, but strangely not for large corporations?? This is the part I don't get.
quote: That's the lazy capitalist's answer to not competing with product quality and innovation in the open, undistorted free market. Only your product gets to talk. You are chosen only because you are the best. Not because of contracts and legal crap.
quote: 2) You cannot take a data set and say hey there is some correlation.


text:
Real-World Windows Azure with Sage
- Posted: Jul 20, 2012 at 4:12PM
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In this episode, niner Brady Gaster interviews Lead Architect, Chad Busche from Sage to discuss the company's hybrid cloud solution, Sage Construction Anywhere. The organization chose Windows Azure due to the security features and fast deployment timeframe among other reasons. Tune in to see the full video and find out more.
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Our new Braque Francais puppy from France - Braque Francais Hunting Dog Pictures
Breed: Braque Francais
From: Brandon & Kristy Brunner
Website: http://www.chequamegons.com
Posted: Aug 29, 2010
Just returned from France with our new Braque Francais, Feelin Blue.


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Built for the future envelope-pushers.
The Rome Kids' Label Rocker Snowboard is for groms who have no fear about launching off side hits, popping into boardslides, and straying into the trees in search of powder. With a twin shape, catch-free profile, and smooth flex, the Label Rocker will help them take their skills to the next level.
The newly revised NoHang-Ups Rocker 2.0 profile features a large flat area underfoot with concave rocker zones at the tip and tail that lift the contact points off the snow to cut down on slams while still providing a large, flat stable platform for loading up ollies and locking into rails. A true twin shape helps them dial in riding switch, while a tip-to-tail wood core provides a poppy feel and a continuous flex. The XTRD base absorbs wax well to keep them cruising across flat zones and traverses, and it can be easily repaired when they ding it up in the park.
- Flat profile with lifted contact points
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- Item #ROM005H