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Isis Pharmaceuticals To Present At The Leerink Global Healthcare Conference
CARLSBAD, Calif., Feb. 6, 2014 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS), the leader in antisense therapeutics, today announced that management will present a company overview at the 2014 Leerink Global Healthcare Conference on Thursday, February 13, 2014 at 1:50 p.m. ET in New York, NY. (Logo: http://photos.prnewswire.com/prnh/20130807/LA60006LOGO)A live audio webcast of the presentation will be available on the "Investors & Media" section of the Company's website, www.isispharm.com. A replay will be available on the Isis website within 48 hours and will be archived for a limited time. ABOUT ISIS PHARMACEUTICALS, INC. Isis is exploiting its leadership position in antisense technology to discover and develop novel drugs for its product pipeline and for its partners. Isis' broad pipeline consists of 31 drugs to treat a wide variety of diseases with an emphasis on cardiovascular, metabolic, severe and rare diseases, including neurological disorders, and cancer. Isis' partner, Genzyme, is commercializing Isis' lead product, KYNAMRO ®, in the United States for the treatment of patients with HoFH. Isis' patents provide strong and extensive protection for its drugs and technology. Additional information about Isis is available at www.isispharm.com. FORWARD-LOOKING STATEMENTSThis press release includes forward-looking statements regarding Isis' business and the therapeutic potential of Isis' technologies and products in development. Any statement describing Isis' goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties, particularly those inherent in the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. Isis' forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Isis' forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Isis. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Isis' programs are described in additional detail in Isis' annual report on Form 10-K for the year ended December 31, 2012, and its most recent quarterly report on Form 10-Q, which are on file with the SEC. Copies of these and other documents are available from the Company. In this press release, unless the context requires otherwise, "Isis," "Company," "we," "our," and "us" refers to Isis Pharmaceuticals and its subsidiaries. Isis Pharmaceuticals® is a registered trademark of Isis Pharmaceuticals, Inc. KYNAMRO® is a trademark of Genzyme Corporation.
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text: Prepared by hand, this award-winning mac and cheese features luscious chunks of lobster—sustainably harvested from the waters off the coast of Maine—paired with shell pasta and a mascarpone-cheddar sauce blended with a delicate lemon-herb butter. A golden topping of panko crumbs and Parmesan cheese adds satisfying crunch to every bite. Four generously sized servings arrive in reusable porcelain ramekins, ready to bake whenever you are. Based in coastal Maine, Hancock Gourmet is a family-run company focused on high-quality seafood specialties prepared with fresh, locally caught Maine shellfish and inspired by family recipes.

subset: commoncrawl


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Huntley Marine Ski & Wakeboard boats for sale
Weâre your family-owned and operated boat sales and service headquarters, serving Charlotte and the two Carolina's since 1964. Huntley Marine is an Authorized Dealer for new Hurricane deck boats, Godfrey Pontoons, Carolina Skiff and PolarKraft fishing boat packages, and Stingray family runabouts. So if you want a new or used boat for just on the lake, or just offshore, or to wakeboard and surf behind, Huntley Marine is your best choice. We also carry a complete line of parts and accessories for all your boating needs. Our fully qualified technicians have over 100 years combined experience on Yamaha outboard motors, Volvo and Mercruiser stern drives, and PCM inboards.
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Worked With:
Olivia Thirlby
Birth Name: Olivia Thirlby
Born: 10/06/1986
Birth Place: New York City, New York, USA
Born: 10/06/1986
Birth Place: New York City, New York, USA
Born in 1986 in New York City, Thirlby was raised an only child by her executive mother and contractor father. She pursued her interest in acting while attending the prestigious Friends Seminary school in downtown Manhattan, taking summer trips to the Catskill Mountains and Long Island to attend various workshops and performing arts camps. After graduating from high school, she studied briefly at London's Royal Academy of Dramatic Arts before landing her debut role as a frightened passenger in "United 93." A few years later Thirlby scored her first TV series with the short-lived "Kidnapped," which she followed up with a sizable role as the title teen's supportive, sarcastic best friend in "J... Continue Bio >>
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We take a look at Ben Stiller's career leading up to the release of Madagascar 3
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We take a look at the Oscar nominee's acting career leading up to the 2012 Academy Awards
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Take a look at Jack Black's career leading up to the release of The Big Year
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The Oscar contender acts on his moody impulses.
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text:
Molang Teatime Atom Theme
by DLTO
Developer Notes
Introducing, Atom Themes to make your Atom launcher more beautiful.
Emotionally designed themes, themes by collaboration work with famous artists, K-Pop star themes are coming soon. Please download Atom Store and experience our wonderful themes.
***How to Use
1.Install Atom Launcher if you do...


text:
DPAA All Membership and Agency Advisory Board Meeting
All DPAA member companies and Agency Advisory Board members are invited to attend. Breakfast is served at 8:30 and the meeting will begin promptly at 9am EST and conclude at 12:00 with lunch and committee breakouts from 12-1.
If you have questions about presentation materials or would like to attend via WebEx please contact Ryan Pogy.
If you are not a member but are interested in finding out more or are interested sponsoring a breaktime presentation please contact Ryan Pogy.
All meetings will be held at the DPAA offices:
Contact Ryan for specific meeting rooms.
Ryan Pogy


text:
What's next: Rainbow and WebRTC
Anant Narayanan
It's been a while since the last release of the Rainbow add-on. We wanted to give everyone a quick update on the roadmap for Rainbow and real-time communication on the Web. Integration with WebRTC When we first released Rainbow late … Continue reading


text:
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Ancestry.com - Search Newspapers & Publications
Searchable indexes; database results and some digitized images available with fee-based subscription.
NewspaperARCHIVE.com - Explore Historical Newspaper Archives Online $
The world's largest online newspaper archive. Featuring billions of articles from historical newspapers around the U.S. and the world. This unique archive spans more than 400 years of family history, small-town events, world news and more. Searchable database with the number of results shown, images available with a fee-based subscription.


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Integrative Reflexology a Primer
A complete basic Integrative Reflexology session from start to finish created and taught by nationally recognized and certified Massage Therapist, Claire Marie Miller. Integrative Reflexology is easily applied without thumb or finger walking. Book includes the landmarks, the bones, and a complete basic session in black and white photos. 31 pages


text:
CROWNSVILLE, Md. (WUSA) - Seventy-five firefighters battled a two-alarm fire at a single family home in Crownsville, according to a spokesman for the Anne Arundel County Fire Dept.
The home in the 1300 block of General's Highway was engulfed in flames when fire crews were called at about 6:30 Monday evening. The discovered fire concentrated in the rear half of the building and were told that a victim might still be in the house at that time.
Firefighters from Anne Arundel County, the City of Annapolis and the U.S. Naval Academy responded to the scene. Firefighters found a 75-year-old man in the basement of the home. He was taken to Anne Arundel Medical Center in Annapolis where he is reportedly in critical condition.
No one else was in the home at the time of the fire, according to the spokesperson. Three other persons have been displaced as a result of the fire and are being helped by the Red Cross. The home apparently had been converted into three apartment units.
The damage estimate is $75,000 and the cause of the fire is under investigation but appears to be electrical in nature.


text:
- Details
- Published on Tuesday, 23 September 2003 20:51
- Written by Dave Snow
YAMADA, Masaye Uriu,
Following her husband's death in 1975, Masaye became an enthusiastic amateur photographer, went back to college, and in her late 60s graduated from San Francisco State with a B.A. degree in Japanese language and culture. She was a second mother to many of her fellow students, enjoying photography field trips and their friendship and fellowship. She subsequently tutored students in English as a second language and mentored students from Japan. She studied brush painting, tea ceremony, koto, and Ikebana. She also enjoyed gardening and attending the opera.
Masaye moved to Dallas, Texas in 1995 to live with her daughter and son-in-law. She and her daughter built a house together so that Masaye could live with family. In her last 5 years, Masaye suffered a series of progressive health problems, through which she proved wonderfully resilient, adjusting gracefully to each new setback. Throughout her final months and years, she remained fun-loving and cheerful, sharing much laughter and forming bonds of love and friendship with her excellent caregivers Linda Macias and Carmen Hernandez, and winning the affection of all who came to know her.
Masaye was preceded in death by her husband Paul Yamada, her brother Isamu, and sister Tomiko. She is survived by her son Kenneth, daughter Joyce, her brothers Kiyoto, Masashi, Dale, Stanley, Clarence, her sisters Mitsuko, Fumiko, Haruye, and by numerous nephews and nieces, of whom she was very fond.
The Memorial Service will be at the Aldersgate United Methodist Church, 4243 Manuela Avenue, Palo Alto on Saturday, October 4 at 2:00 P.M. Inquiries may be directed to 214-943-5347 or e-mail to: In lieu of flowers, the family suggests contributions to the Visiting Nurse Association, 1440 Mockingbird Lane, Suite #500, Dallas, TX 75247, who provided excellent hospice care for the final 1.5 years of Masaye's life, or to a charity of choice.
THRUSH, Margaret V., 88,
She is survied by her four sons; Todd of New Orleans, LA, Tom of Denver, CO, Tim of Los Altos, CA and Trent of Sunnyvale, CA; her brother John Clark and two sisters Jane Parker and Ann Auskings of Mt. Vernon, OH; two grandsons and several nieces and nephews; her husband, a TWA Captain, Roy Thrush; brothers Ralph and Charles Clark and sister Mildred Ewalt died previously.
Services will be held at Spangler Mortuaries in Los Altos at 12:00 noon on Friday, September 26. Donations can be sent to the United Methodist Church, 655 Magdalena Ave., Los Altos, CA 94024.


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DougFromNYCFollow DougFromNYC
I am an attorney moving from the U.S. Virgin Islands to NYC in September of 2008. Before I start up my new gig my buddy and I will be travling to the Bali Resort from August 25 to September 3, 2008. Let us know if you'll be there too!
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12 Wooden Tabletop Trees
Posted by Emily | Filed under Design Tips, Musings
Tabletop trees bring holiday flair to small living rooms, console tables, kids' rooms … really any space in the home. I'm particularly fond of wooden versions. Whether decorated or left unadorned, they can be a lovely (and often more environmentally-friendly) alternative to live, cut, or artificial trees. Here are 12 of my favorite wooden tabletop trees. In many cases, their modern shapes and neutral colors extend their appeal beyond the holidays, too.
I gasped the first time I saw Büro North's Frigg, Rindd, and Gryder trees. Not only are they incredibly stylish, but they're also sustainably designed and produced in Melbourne, Australia.
The Wooden Die-Cut Evergreen Trees on the left are actually sold as wedding table centerpieces but they could certainly be used in the home, as well. At right, Crate & Barrel's Wooden Trees made from plywood with a white lacquer finish.
Tags: artificial trees, decorative trees, holiday decorating, holiday trees, miniature trees, tabletop accessories, tabletop christmas trees, wooden trees


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text: The Kikuichi history of fine craftsmanship dates back to 12th century Japan, when an ancestor became a swordsmith for the emperor, marking each sword with the monarch's chrysanthemum symbol. Today this proud tradition of metalwork continues with beautiful cutlery etched with this enduring emblem. Handcrafted in Japan, the yanagi is the classic Japanese knife used to prepare sushi and sashimi, slicing through delicate fish with precision and ease.


text:
If you've ever used the Bone Tool to chain together movie clips, you might have noticed that it can be kind of hard to control the movement of those various armatures. Well, with Flash Professional CS5.5, you can now pin those armatures down to the stage to give you better control over the bones you want to manipulate. I'll show you what I'm talking about. Here I just have a simple character, and there are already some bones, or armatures, connecting his different limbs. So I'm going to go ahead and move these into place just by using my selection tool. I'm going to jump in here and make sure I can move these different parts of his arm together, because I want to connect them to the body. I'm going to select my bone tool and, just clicking on this center point, I can easily connect, say, for instance, his torso to his upper arm to his lower arm, just like that. All right. And now with my selection tool I can pull it out, and obviously we don't like this disjointedness right here. So what I want to do is I'm going to just move this back into place, kind of like that. And then I can select this armature. And I really want to lock down this armature to keep it from moving. So if I go to the properties panel, right over here, it's just this checkbox. It's as simple as checking on it. You can see that this X appears, and now I can rotate that arm with much more control. Again, I can jump in here and select that armature, select Pin to pin down that part of the arm, and I can go through and do that for every armature I really want to lock down, just like that. So now, of course, each leg I can move out. Each arm I can move out just fine to really get the positioning that I want for this character. And I'll just switch over to this final file, because really the result will be something more like this. And even in this example, for instance, if I take a look at it notice that it doesn't have any pinning on any of these joints, because you can pin it down and then move your character to a different pose, and basically unpin when you're done manipulating those different bones. But, again, it's done fairly easily. Being able to pin these armatures will give you more control over your animations allowing you to work much more efficiently. Thanks for watching.
Flash Professional CS5.5 - Pinning Support for IK
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About This Episode
Ever wanted even more control when using the Bone tool? In this tutorial, Paul Trani shows you how to use Flash Professional CS5.5 to pin the tail of inverse kinematics (IK) bones to the stage while posing an armature. Pinning support enables you to isolate armatures for more precise control when posing.
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Runtime : 00:02:35 Added : 04/10/2011
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text:
Jayden is back and curvier than before. She wore a sexy one piece black g string, stockings and high heels to our rooftop shoot. I was able to capture her amazing ass from all angles. Jayden revealed some of her sexual fantasies while she seductively bounced her booty. We eventually went indoors where she smothered Voodoo with her mega ass. When Voodoo resurfaced, he had the pleasure of fucking the best piece of ass that I have seen in a long time.
"Hips Dont Lie"
Abbey Brooks
"Bathtub Beauty"
Anikka Albrite
"Padded Seat"
Katie Cummings
"Double Dipping"
Amy Brooke
"Star Quality"
Rachel Starr
"Curves And Cum"
Kelly Divine
Nikki Sexx
"Hot Box"
Mia Malkova
"Body Of A Goddess"
Mia Malkova
"Have Mercy"


text:
Now that the new starters has been released, everyone is asking: Which starter is the best?
How about testing this out with a tournament? rules: you can use one of the starters and edit out maximum 4 cards with other shielded cards.
then we make a statistic from it, and present the outcome to the community.


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text:
With my gloriously twisted mind, I picture Iron Man as a dude that got his super powers from being slammed in the face with a heavy metal iron by a pissed off wife. That sort of Iron Man wouldn't be very pretty… but maybe his shirt would always be properly de-wrinkled.
Anyway, let's discuss the Iron Man we already know and love. The first Iron Man was a smash hit. We love our superhero movies! Iron Man is sort of reminiscent of Batman, only a lot more colorful and dare I say, cocky. He's rich and can build/buy anything he wants. He's also the most eligible bachelor in town. In the end, unlike Batman, he unveils his secret identity and tells the world he is Iron Man. If you haven't seen the first one, you must live under a rock. In case you do, in fact, live under a rock, here is the basic synopsis:
Our hero is Tony Stark, the super wealthy CIO of Stark Industries. Stark's company is dedicated to weapons manufacturing on a massive scale. In Afghanistan on a mission to demonstrate new missiles, Tony and his convoy are attacked. He is taken as a hostage by the enemy. While in captivity, Tony builds an Iron Man suit and escapes. When he comes home safely he stops weapons manufacturing so he can dedicate more time to perfecting his suit which he then uses to fight evil.
Now the much anticipated sequel, Iron Man 2, hits theaters tomorrow, Friday April 7th. You will see some of the original cast (Robert Downey Jr. and Gwyneth Paltrow) along with some new sexy familiar faces such as Scarlett Johansson and Mickey Rourke. This sequel promises to deliver action packed fight scenes coupled with Robert's famous sarcastic humor.
Now you don't have to just sit back and watch Iron Man kick the bad guy's asses and run away with the hot girls, but you can BE Iron Man and experience the life of a superhero for yourself! We've got the new movie costumesand the comic book version costumes for kids and adults. If you don't want to go all out but still want to pick up chicks, just borrow one of your friends kids and dress him up like Iron Man. It's almost better than walking a poodle through the park. The ladies will be running over to say how cute your little iron man is. Superheros are strategic and you'll hit a home run with this one.


text:
May 6, 2016
Tallahassee, FL—Foreclosure fillings in Florida jumped 20 percent in the last year. The fast-track foreclosure bill is aimed to speed up and clean up the process.
Jason Naumann, of Naumann Group Real Estate: "The bill as its passed would decrease the time frame from default to foreclosure, which will stop a lot of those people who are taking advantage of the system and get it through the pipeline quicker then it is currently."
The process currently takes almost five-years to run it's course in the state.
Now, with this bill, it could only take one year.
Homeowners are in an uproar with new provisions that could also speed up the deficiency judgment, which allows the bank to recoup the money from the foreclosed homeowner.
Alex Parker of Lord & Stanley Realty: "The new bill that they are looking to put through the system would take it from a five year system in which the bank could come after you for the deficiency judgment and shorten that down to a one year period to pursue a deficiency judgment. Whether that would be good or not, that is still yet to [be] seen."
State Representative Kathleen Passidomo of Naples is sponsoring the bill to go before the house.
Although there are many provisions consumer advocates and homeowners are weary of, the Naumannn Group says, the rise of foreclosures in the state should not make homeowners afraid of the housing market.
According to the Naumann Group, the prices on homes have stabilized and the interest rate is at 3 percent.
The bill still needs approval from the Senate, but lawmakers hope that if it passes, it can go into effect July first.
The foreclosure process both now and on the new bill depends on the bank and the loan the homeowners took out originally.
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When he was young, Pryce was a skilled Trainer, winning many battles and also treated his Piloswine like family. Unfortunately, the two eventually found themselves up against a trainer with a Magmar. Pryce shielded Piloswine from Magmar's Fire Blast but both were badly injured as a result.
Piloswine left the cabin they were staying in to go get some herbs to help cure Pryce's burns. However, it got frozen on the way back and stayed there for several years. Pryce, believing his Piloswine had abandoned him, changed overnight, becoming an angry, bitter man who believed Pokémon and humans did not deserve to be friends.
Several years later, Pryce and Ash found Piloswine frozen in a block of ice. Thanks to Ash's Pikachu and Cyndaquil, Piloswine was freed from its ice prison, and Pryce was overjoyed. His anger and bitterness melted away when he was reunited with his beloved Pokémon.
Piloswine was later used in Ash's Gym Battle where it successfully defeated Ash's Cyndaquil. It nearly defeated Ash's Pikachu before Pryce threw in the towel, forefeiting the match as Piloswine had become tired.
Known moves
|Nice Pryce, Baby
|Take Down
|Nice Pryce, Baby
|Fury Attack
|Nice Pryce, Baby
|Nice Pryce, Baby
|+ indicates this Pokémon used this move recently.*
- indicates this Pokémon normally can't use this move.
- Whilst battling Cyndaquil, Piloswine used a Blizzard that not only caused damage to Cyndaquil but also hid Piloswine from veiw. This was probably due to the Snow Cloak ability. However it should be noted that special abilities had not been invented at this time. Also, in the games, Snow Cloak is only activated if it is hailing.
- Unshō Ishizuka who plays the Narrator in the Japanese version voices Pryce's Piloswine in both the Japanese and English versions of the anime.


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No matter if it is duck season or rabbit season, you should put on Camo Duck Hunter Adult Jacket if you want to dress like a hunter. Available in one standard size that fits up to a 42-inch chest, the brown camouflage jacket features illustration of brown leaves, twigs and branches as well as some green leaves. These images of vegetation make it easier for a hunting to blend in with forest surrounds and they are less likely to be seen by their prey. This style of dress has become more popular with the popularity of the reality TV series Duck Dynasty, about a family that sells duck hunting paraphernalia. Make sure to order some accessories so you are prepared to be the hunter this Halloween. If you want a couple's costume, your partner can dress as another hunter or a wild animal. Hat, beard, shirt and pants are not included.
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Become the princess of a great Native American tribe with our Girl's Princess Wildflower Costume. This ensemble consists of the dress with matching poncho, hair accessories, and boot covers. Both the brown poncho and dress feature jagged trims that are lined with a tan fringe. A geometric pattern creates a border around the neckline and bottom of the poncho. Strings with beads attached to the ends dangle down from the collar area. Have your daughter wear the feathers in her hair to complete the look. Native American tribes like the Apache, Navajo, and Chippewa spread out across the United States before the Europeans discovered it. Let your daughter imagine that she's a member of one of these tribes with our wildflower costume for girls. Moccasins, tomahawk toys, and Native American drum replicas can be ordered to accessorize it.
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Today, Monday, 7th May, 2012, there will be an important event, the launch of the 2011 State of the World's Volunteerism Report (SWVR), which has been compiled and issued by UN Volunteers, a chapter of the United Nations Development Programme (UNDP).
According to the UNV Programme officer in Tanzania, Stella Karegyesa, the activities for the 2011 SWV report launch will take place today at the Karimjee Hall, Dar es Salaam starting from 9.00am. There will be a number of activities including the presentation of the report, entertainment, debates and a plenary discussion of the report.
The opening remarks of the event will be done by the UN Resident Coordinator and UNDP Resident Representative, Mr. Albeic Kacou; while the presentation of the SWV report will be done by Aygen Aytac.
UNV Tanzania has requested me to be one of the panelists during the discussion of and the launch of the State of the World's Volunteerism Report. Other panelists are Mrs Joyce Shaidi, former Director, Youth Department, Ministry of Labor, Employment and Youth Development; Mr. Moses Mzava, Lecturer at the University of Dar es Salaam; Mr. Israel Ilunde, Executive Director of Youth Partnerships Worldwide; and Mr. Alfred Maghema, a student at Sokoine University of Agriculture, and Executive Director of Tanzania Youth for Community Prosperity (TYPC). These panelists will attempt to discuss the report while drawing life experience from our society. The aim is to analyse the extent to which volunteerism has and can support socio-economic development in Tanzania.
The report, which is the first UN report ever on volunteerism and is commissioned by the UNV programme seeks to draw attention to the state of the world volunteerism by researching different definitions of volunteerism and documents the impact of volunteerism on peace and development around the world as far as feasible.
SWVR also attempts to demonstrate that volunteerism is a global phenomenon characterized by commonalities as well as by differences reflecting local, social, economic, gender, religious and global factors. Above all, it tries to raise awareness and recognition of volunteerism and gain widespread support in order to fully realize and harness the potential and power of volunteerism for transformation change and sustainable peace and development.
According to Flavia Pansieri, the Executive Coordinator, UN Volunteers, the focus of the report is on universal values that motivate people the world over to volunteer for the common good and on the impact of volunteer action on societies and individuals. We believe in the power of volunteering to promote cooperation, encourage participation and contribute to the well-being of individuals and of society as a whole.
Launching of SWV report hopes to heighten people's and governments' awareness of the voluntary contributions. It also focuses on stimulating people to offer their services as volunteers, both at home and abroad.
Over the years, governments, businesses, nonprofit organizations, and individuals participated in promoting volunteerism in various activities including: Voluntary community projects; Parades, marches, or rallies; Award ceremonies for volunteers who made significant contributions to their communities; "Time donation" campaigns that involve people pledging hours of voluntary service to specific projects; Companies launching voluntary programs as part of their corporate responsibility; Volunteer competitions; and many other activities.
Volunteerism helps promote the UN's Millennium Development Goals, which include: eradicating poverty; achieving universal primary education; promoting gender equality and empowering women; reducing child mortality and improving maternal health; reversing the spread of HIV/AIDS, malaria and other major diseases; as well as ensuring environmental sustainability.
Volunteerism occurs in every society in the world. Since time immemorial, in our Tanzanian societies people especially in rural areas at various times have devoted their time to support needy people such as the sick, disabled, poor, orphans, during weddings and funerals, when disasters strike, during farming as well as harvesting.
These people did not devote their time to support others expecting to obtain material wealth in return but they did so due to recognition of the importance of non-material attainments to the well-being of individuals and the entire society.
Material improvements such as health, education and decent work remain essential; but also participation, empowerment and active citizenship is very vital. Development is about expanding the choices available to people so they may lead lives that they value. Economic growth is only one means of increasing people's choices.
Volunteerism becomes a very powerful expression of all these, where people can take control of their lives and make a difference to themselves and to those around them.
There are a number of reasons why people engage or should engage in volunteerism. The 2011 UN State of the World's Volunteerism Report (SWVR) highlights that one of the reason is to help eliminate poverty and to improve basic health and education, to provide a safe water supply and adequate sanitation, to tackle environmental issues and climate change, to reduce the risk of disasters, and to combat social exclusion and violent conflicts.
Through volunteerism people can engage in the life of the communities and societies. In doing so, they acquire a sense of belonging and inclusion and they are able to influence the direction of their lives.
As volunteers the income poor realize their assets, which include knowledge, skills and social networks, for their own benefit, their families and their communities. Volunteerism strengthens the capacity of the most vulnerable to achieve secure livelihoods and enhance their physical, economic, spiritual and social well-being.
Volunteerism also promotes the civic values and social cohesion which mitigate violent conflict at all stages and it even fosters reconciliation in post-conflict situations. It supports to build trust and reduce existing social tensions.
Volunteering can help fresh graduates to build their working skills as well as social capital. According to Wikipedia, the social capital generated by volunteering plays a key role in economic regeneration by widening social networks needed by fresh graduates. It is possible that you will be able to obtain information on job opportunities through social networks or the organisation you are volunteering for.
I have personal experience in this. I completed my undergraduate studies in 2001, and I could not obtain any job for about a year. However, during this time I decided to volunteer with a youth NGO. Through this I managed to obtain a lot of information on job opportunities, including a job offer with an international NGO.
I agree with Flavia Pansieri, the Executive Coordinator of UNV Headquarters, who argued that volunteerism is not a wholly panacea to the problems of the world today. It is, however, an essential component of any strategy that recognizes that progress cannot be measured solely in terms of economic return and that individuals are not motivated by self-interest alone but also by their deep held values and beliefs.
Wherever your are, whatever age, I encourage you to make plans to join others or set up a group of people or friends to find some activities which need your time and resources as volunteers within your street and communities. Volunteering matters: light up the world!
The writer is a specialist in Education Management, Economics of Education and Policy Studies. He can be reached through 0754304181 or [email protected]


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Saturday, Jan 26, 2013 7:30 PM EST
The Abbey, Orlando, FL
From the creator of Menopause the Musical, The D* Word (*Ditched, Dumped, Divorced and Dating) follows the woes and wows of four single and single-again women who learn the art of Happily EVEN After. The D* Word gives a voice to everyone who knows the feeling of being D*ateless and D*esperate to the exhilarating freedom of D*ynamic and D*azzling!


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For Large Organizations With Multiple Affiliates
Beyond reducing the price that organizations pay for software licenses over full-packaged product prices, Select Plus offers many other opportunities to maximize the value organizations receive by participating in the program. Helping organizations get the most value from their software investment, Select Plus benefits include:
Customers can choose to purchase software licenses through the Microsoft Volume Licensing program that best meets their needs. The Select Plus offer is a fundamental shift that introduces new ways to license and helps us evolve our future licensing strategy. The advantages to Select Plus over Select include a unique customer ID per affiliate that helps customers better track and manage their software assets. Select Plus also has a non-expiring agreement that eliminates renegotiation and renewal. Customers can take advantage of the improved features of Select Plus with no price change. Because customers just have to issue a purchase order at the program price from a reseller, they do not need to negotiate a new agreement. Organizations have to decide what program choice is best for their purchasing needs, and Microsoft's goal is to offer them flexibility and value.
Software Assurance
You get the full value of 36 months of Software Assurance (SA) benefits with Select Plus, with no proration. In Select, if you are in month 11, you pay for 36 months of SA and receive 25 months of coverage. With Select Plus, you pay for 36 months and receive 36 months of coverage. SA membership is also available with Select Plus.


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Is everyone having a good time? Hynes asked.
The crowd's response was affirmative.
We'll soon change that, he said, before launching into Godspeed.
Curran is also in good humor.
Her second song was a new one called The Wreckage.
The past year obviously hasn't been that positive for her either, she joked.
Sherman Downey followed with a song about the man he hoped he doesn't become.
Maureen Ennis sang a song for the first time since she co-wrote it with two other people. Her nervousness was obvious.
The crowd was appreciative of her effort.


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For added color and texture, serve with a mixed green salad tossed with your favorite KRAFT Lite Dressing.
Serving a crowd? Prepare as directed, doubling all ingredients. Makes 16 servings.
Prepare using KRAFT Hickory Smoke Barbecue Sauce, KRAFT Sweet Honey Barbecue Sauce or BULL'S-EYE Memphis Style Barbecue Sauce.
* Nutrition information is estimated based on the ingredients and cooking instructions as described in each recipe and is intended to be used for informational purposes only. Please note that nutrition details may vary based on methods of preparation, origin and freshness of ingredients used.
This is a really tasty recipe. And it appealed to all my family members which is great. Easy to make.
My husband loved this especially the next, sauce however was a bit thin.


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WASHINGTON (AP) -- President Barack Obama's campaign intends to highlight the president's record with military veterans next year. Republicans are vowing to change high unemployment among veterans in their pitches to military voters.
Next year's presidential contest could involve two major party nominees without any military service for the first time in nearly 70 years, adding a new dimension to the push for support for veterans and military families.
Obama did not serve in the military nor did leading Republican contenders Mitt Romney and Newt Gingrich.
Several states that will be heavily contested next year have a significant military presence, including Florida, North Carolina and Virginia.
KKTV firmly believes in freedom of speech for all and we are happy to provide this forum for the community to share opinions and facts. We ask that commenters keep it clean, keep it truthful, stay on topic and be responsible. Comments left here do not necessarily represent the viewpoint of KKTV 11 News.
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The Power of Independent Thinking
Obamas Historic Visit To Cuba is the Right Policy
Recorded: Wednesday, March 23, 2016
Sr. Fellow Ivan Eland is interviewed on the Larry Conners USA radio show on KTRS. Eland says the 50 years of trying to get rid of the Castro brothers has not worked and its time for a different policy. Now that the Cold War is over, says Eland, Cubas future may be democracy, but not all countries would make good democracies. Cuba must open its economy in some way, he says, because the country needs capital.
Experts: Ivan ElandType: RadioIssues: Politics
Sr. Fellow Ivan Eland Interviewed on Doug Stephans Good Day Radio Show
Recorded: Thursday, August 6, 2015
Sr. Fellow Ivan Eland is interviewed on Doug Stephan's nationally syndicated radio show "Good Day" program. The discussion centered around the Republican Presidential Debate on Aug. 6, 2015. Eland saying the Republican candidates should be concentrating on foreign policy.
Experts: Ivan ElandType: RadioIssues: Defense and Foreign Policy, Politics
What Americans Should Learn from the British Election
Recorded: Wednesday, May 13, 2015
Sr. Fellow Ivan Eland appears on America Tonight with Kate Delaney to talk about government spending out of control. Eland compares the US money supply and spending under George W. Bush and Barack Obama to eating candy and getting a "sugar high" instead of a good balanced diet. British Prime Minister David Cameron has followed the examples of US Presidents Harding, Coolidge, Eisenhower and Clinton and embraced austerity to bring about long term prosperity.
Experts: Ivan ElandType: RadioIssues: Defense and Foreign Policy, Government Power, Politics, Terrorism and National Crises
Partitioning Iraq for Peace
Recorded: Tuesday, March 31, 2015
Senior Fellow Ivan Eland, author of Partitioning for Peace, appeared on "Doug Stephan's Good Day" radio program. Eland talks about the state of terrorism in the Iraq and whether the US creates more of a problem with its intervention. He also discusses the question of how ISIS is different than other terror groups.
Experts: Ivan ElandType: RadioIssues: Civil Liberties/ Human Rights, Culture/ Society, Defense and Foreign Policy, Diplomacy and Foreign Aid, Freedom, History (International), Nationalism, Politics, Race Issues, Religion, Terrorism and National Crises
Ivan Eland: Is Obama the Worst President Ever?
Recorded: Tuesday, November 4, 2014
Sr. Fellow Ivan Eland, author of the newly updated book Recarving Rushmore which ranks all of the U.S. Presidents in terms of peace, prosperity and liberty, talks about President Barack Obama and his ranking. Obama ranks near the bottom, but it was an early 20th century president that takes the title of "Worst President" in terms of peace, prosperity and liberty. Eland spoke with Kerry Lutz of the Financial Survival Network.
Experts: Ivan ElandType: RadioIssues: Constitutional Law, Economic History and Development (U.S.), Government Power, History (U.S), Political Ideology and Philosophy, Politics
Ivan Eland on Ranking US Presidents
Recorded: Sunday, October 26, 2014
Ivan Eland, Senior Fellow at the Independent Institute, appears on Fox & Friends to discuss his updated version of "Recarving Rushmore."
To order copies of "Recarving Rushmore: Ranking the Presidents on Peace, Prosperity, and Liberty," click here.
Experts: Ivan ElandType: TelevisionIssues: Bureaucracy and Government, Civil Liberties/ Human Rights, Culture/ Society, Defense and Foreign Policy, Democracy, Diplomacy and Foreign Aid, Fiscal Policy/Debt, Freedom, Government Power, Government Secrecy, Government Waste/Pork, History (U.S), Nationalism, Political Ideology and Philosophy, Politics, Regulation and Deregulation, Terrorism and National Crises, Trade
Ivan Eland on RT Television: Coalition of the Killing
Recorded: Wednesday, September 24, 2014
Senior Fellow Ivan Eland appears on RT Television to discuss the recent US-led bombing Syria. Eland says the US is backing into an intervention in Syria, where the US is heading for disaster.
Experts: Ivan ElandType: TelevisionIssues: Defense and Foreign Policy, Diplomacy and Foreign Aid, History (International), Politics, Terrorism and National Crises
Ivan Eland Speaks on Recarving Rushmore at LPAC 2014
Recorded: Friday, September 19, 2014
Senior Fellow Ivan Eland speaks on Americas Presidents at the 2014 Liberty Political Action Conference .
Experts: Ivan ElandType: TelevisionIssues: Constitutional Law, Culture/ Society, History (U.S), Political Ideology and Philosophy, Politics


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The South Oldham Rotary Club honored the February Students of the Month at its regular meeting Feb. 8. Vocational Services Director John Oliva presented the students with a framed certificate. William Jordan Ellis is a senior at South Oldham High School. Ellis is the son of Bill and Elizabeth Ellis. He plans to attend The University of Kentucky, Centre College or Eastern Kentucky University and obtain a major in pre-med and biology. Ellis plans to continue to medical school and become a doctor.
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The Standard and Poor's 500 index closed at its highest level ever Thursday, driven by more encouraging data on the U.S. economic recovery. The government said the economy grew at an annual rate of 0.4 percent in the October-December quarter, slightly better than previous estimates. The revision reflected stronger business investment and export sales.
South Korea's Kospi rose 0.8 percent to 2,010.40. Taiwan's TAIEX advanced 0.7 percent to 7,920.38. Markets in Hong Kong, India, Australia, New Zealand, Indonesia, Philippines and Singapore were shut for Good Friday.
Japan's Nikkei reversed early losses to rise 0.4 percent at 12,389.16. Gains were muted, however, as the yen leveled off against the dollar and the government released figures for February showing the country's jobless rate edging up while industrial production fell slightly.
Newly appointed central bank governor, Haruhiko Kuroda, has pledged to work with the government to end decades of growth-inhibiting deflation. His outspoken calls for action have raised hopes for results but some analysts said they may also have created unrealistic expectations for a turnaround.
"Unfortunately, the markets' expectations of the new Governor are so high that they will be almost impossible to meet, let alone beat," said analysts at Capital Economics in a market commentary.
Shares in mainland China fell amid limited trading volume, analysts said. The Shanghai Composite Index was 0.1 percent lower at 2,233.23 and the Shenzhen Composite Index fell 0.3 percent to 927.06.
Peng Yunliang, a Shanghai-based analyst, said shares in brokerage houses declined following the release Thursday of official policies aimed at tightening control over wealth management products.
In Europe on Thursday, markets responded positively to the calm reopening of Cyprus's banks. Banks in the Mediterranean island nation were shut for nearly two weeks as the government negotiated a rescue loan from international lenders to prevent the financial system from collapsing. The FTSE 100 index of leading British shares, Germany's DAX and France's CAC-40 all closed higher Thursday.
Italy's political uncertainty will also remain in the spotlight. Following inconclusive elections around a month ago, the country is still without a government, and that's raised concerns over its future economic path. Italy is the third-largest economy of the 17 countries that use the euro.
The Standard and Poor's 500 index closed at a record Thursday, surpassing its previous record close of 1,565.15 set in October 2007. The Dow, which surpassed its previous all-time high at the start of the month, also rose.
The Dow Jones industrial average gained 0.4 percent to close at 14,578.54. The S&P 500 advanced 0.4 percent to close at 1,569.19. The Nasdaq composite index added 0.3 percent to 3,267.52. U.S. stock markets will be shut for the Good Friday holiday. Thursday was the last trading day of the first quarter.
The New York Mercantile Exchange, where benchmark oil is traded, was closed for the Good Friday holiday.
In currencies, the euro rose to $1.2826 from $1.2822 late Thursday in New York. The dollar fell to 94.07 yen from 94.13 yen.
AP researcher Fu Ting contributed from Shanghai.


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Tile Love: Lush Henry Road
Posted by Emily | Filed under Inspiration, Musings
I love the bold, colorful textile designs of Los Angeles-based design studio Henry Road. Designer Paula Smail says that her aesthetic is influenced by the Marimekko blinds that hung in her childhood home in South Africa, "women wrapped in swathes of stunning African cloth," and artists like Mark Rothko.
Earlier this year Henry Road collaborated with modern glass tile company Modwalls, and the results are stunning with a wallpaper-like effect. The five Henry Road designs in the collection are kiln fired to the back of Modwalls' Lush glass tiles. They come in several colorways with custom options available.
I'm considering using the daisy-colored Gloria Cloud tiles for a mini kitchen backsplash but really wish I could do a big project. Wouldn't those blue Circles tiles look lovely in a shower or even a swimming pool?
See more at Modwalls.
Tags: backslpash tile, bathroom tile, ceramic tile, decorative ceramic tile, glass tile, henry road, kitchen tile


text: The Department of Music is pleased to announce audition dates for acceptance and scholarship consideration for the Fall 2013 academic term. NEW AND PROSPECTIVE STUDENTS Students new to UAH Music who are interested in a Music major or minor may audition on either January 19, 2013 or Feburary 16, 2013. Email firstname.lastname@example.com to arrange an audition time. More information about audition requirements, repertoire, and procedure may be found HERE. RETURNING STUDENTS Current UAH Music Students who wish to be considered for scholarship in 2013 will audition in Music Forum on January 24, 2013. Sign up for the audition HERE. SCHOLARSHIP CONSIDERATION All students who wish to be considered for ANY scholarship must first complete a Scholarship Application found HERE.


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May 2, 2016
An elderly driver has been charged after troopers say she made on U-turn on Highway 17, causing another vehicle to land on its top.
The crash happened around 8:00 a.m. in front of the Wilco Hess in Bridgeton.
Troopers say Maria Dzwonkowski of New Bern was northbound and tried to make the U-turn in front of the convenience store. They say her vehicle collided with a southbound vehicle, driven by Linda Smith of Vanceboro. Smith's vehicle flipped over and the highway was blocked for about a half hour.
Smith was taken to CarolinaEast Medical Center where she was treated for minor injuries and released.
The 77-year-old Dzwonkowski has been charged with failure to yield.
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BW072: The Clubsplosion Begins!
this wiki
Episode Plot
The roar of the crowd, the sensation of competition, the smell of hot dogs. These are the things that best describe a major sporting event. This is not it. After arriving at Toaru Town, Ash and co. enter the Clubsplosion Tournament, sponsored by the Pokémon Battle Club hosted by Don George where the winner will feel the thrill of victory and the agony of defeat. It's looking like the Don Battle Tournament all over again in Nimbasa Town as Bianca, Georgia, Burgundy and Trip arrive on the scene as well with some brand new surprises for Ash and co., like Trip's Gurdurr evolving into Conkeldurr. The prize this time its a year's supply of six Pokémon Boost Vitamin Drinks which include HP Up, Protein, Iron, Zinc, Carbos and Calcium. What could be in store for Ash, Iris, Cilan, Stephan and all of their friends and rivals? Will soon find out as Round 1 of the Clubsplosion Match Ups begins now!
- Montgomery
- Simisage
- Conkeldurr
- Throh
- HP Up
- Protein
- Iron
- Carbos
- Calcium
- Zinc
Tournament Match-ups (First Round)
- Stephan Vs. Edmund
- Flora Vs. Cilan
- Angus Vs. Ash
- Burgundy Vs. Iris
- Betty Vs. Getty
- Gail Vs. Georgia
- Montgomery Vs. Delbert
- Trip Vs. Bianca
Advancing to the next round
- Stephan by defeating Edmund
- Cilan by defeating Flora
- Ash by defeating Angus
- Ash: Ah. Again?
- Ash's Pikachu; Pi-ka-chu.
- (After falling into the water).
- This episode marks the first ever appearance of the boost drink set, which boosts the corresponding stat of one Pokémon.
- Trip's Gurdurr evolved into Conkeldurr. How that happened without Trip trading his Gurdurr is unknown.
- Trip's Gurdurr was in the flashback scene since the first Don Battle Tournament was appeared against Cilan and his Dwebble and now it evolved into its final stage.
- This is the second time Ash and co., along with their friends and rivals (minus Luke) entered the Don Battle Tournament in another town near Mistralton City Don George has hosted. First was BW041: Reunion Battles In Nimbasa! where Luke goes along with Ash and co. including their friends and rivals entered the first Don Battle Tournament in Nimbasa Town.
- Also, this is the second time Ash and co. along with their companion ran into Bianca again while on their way to the second Don Battle Tournament as Ash fell in the water on purpose. First was BW041: Reunion Battles in Nimbasa! when Ash fell in the fountain first, and now he fell in the small stream along with Pikachu.
Who's That Pokémon? US: Conkeldurr
|This article is an anime stub.
Please help the Pokémon Wiki by expanding it.


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Ocean Environmentsshowing only Coastal and Estuarine Show all Ocean Environments
Subject: Oceanography
Earth System Topics: Oceans Show all Earth System Topics: Oceans
Ocean Environments Show all Ocean Environments
Coastal and Estuarine8 matches
Resource Type: Activities
Results 1 - 8 of 8 matches
Estimating Exchange Rates of Water in Embayments using Simple Budget Equations.
Keith Sverdrup, University of Wisconsin-Milwaukee
Simple budgets may be used to estimate the exchange of water in embayments that capitalize on the concept of steady state and conservation principals. This is especially true for bays that experience a significant exchange of freshwater. This exchange of freshwater may reduce the average salt concentration in the bay compared to seawater if it involves addition of freshwater from rivers, R, and/or precipitation, P. Alternatively, it may increase the average salt concentration in the bay compared to seawater if there is relatively little river input and high evaporation, E. Since freshwater input changes the salt concentration in the bay, and salt is a conservative material, it is possible to combine two steady state budgets for a bay, one for salt and one for water, to solve for the magnitude of the water flows that enter and exit the bay mouth. Students will make actual calculations for the inflow and outflow of water to Puget Sound, Washington and the Mediterranean Sea and compare them to actual measured values.
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Oceans Socratic Questioning
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A beach is oriented east-west. It is bordered by bays at both its east and west ends. A current flowing parallel to the beach transports sand from west to east. In which bay will a spit form? a) east b) west
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At which location would the waves break further from the beach? a. A b. B


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WASHINGTON, DC (WUSA9) - Former President of the United States Bill Clinton will be Howard University's 2013 Commencement speaker the University announced in a press release Tuesday.
President Clinton will deliver the Commencement address on Saturday, May 11 on the main campus, according to the report.
"We are thrilled that President Clinton has agreed to deliver this year's Commencement address," University President Sidney A. Ribeau said in the press release. "As a preeminent leader, humanitarian and advocate, his extraordinary global work and commitment to public service will inspire the class of 2013 as they prepare to make their mark on the world."
Read the full press release on Howard University's website.


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Far Cry Vengeance
Far Cry Vengeance - Trailer #3
Based on the Far Cry Instincts Evolution, Far Cry: Vengeance has a new storyline, new maps new weapons, and takes of the Wii Remote and Nunchuk allowing players to drive, shoot, slash, jump and climb their way through a rebel-infested, tropical hell.
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A three and a half minute trailer featuring Jinx interviewing J.F. Dugas, the creative director for Far Cry and footage from Far Cry: Vengeance.
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Eight months and counting. The curtains are hung. The crib is just right, and the rocking chair waits in the corner. You just need those few final touches to create the perfect nursery for your baby. These beautiful wooden hanging letters add that personal touch to your baby's nursery by displaying your baby's name in an array of colors, fonts and designs. This item is custom made especially for you upon order. Please note, the cost listed is per letter, so you can decide to spell out a whole name or word, or just do a monogram or initial!Personalization or special instruction inscription boxes will only hold 200 characters. Please include any additional notes or requests in the Comments box during checkout.
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May 3, 2010
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Rivals.com Football Recruiting
The first-ever Midwest Elite Combine attracted players from all over the Midlands and Midwest. The camp featured several highly recruited prospects, but several sleepers and underclassmen also emerged. Rivals.com's Jeremy Crabtree breaks down camp MVP Darrian Miller and other standouts from the event. ...More... To continue reading this article you must be a member. Sign Up Now!
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Apparently molding up-and-coming pop stars is a well-paid gig, especially if you're Christina Aguilera. Sources tell "The Hollywood Reporter" that the pop star makes 225-thousand dollars per episode of NBC's hit show "The Voice." That's reportedly more than fellow coaches Cee Lo Green, Adam Levine and Blake Shelton make combined. But executives say they're willing to pay the price for ... Read More »
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Peripheral Arterial Disease of the Legs
What is peripheral arterial disease of the legs?
Peripheral arterial disease (PAD) is narrowing or blockage of arteries that causes poor blood flow to your arms and legs. When you walk or exercise, your leg muscles don't get enough blood and you can get painful cramps.
Peripheral arterial disease is also called peripheral vascular disease. This topic focuses on peripheral arterial disease of the legs, the area where it is most common.
What causes PAD?
The most common cause is the buildup of plaque on the inside of arteries. Plaque is made of extra cholesterol, calcium, and other material in your blood. Over time, plaque builds up along the inner walls of the arteries, including those that supply blood to your legs. High cholesterol, high blood pressure, and smoking all contribute to plaque buildup.
If plaque builds up in your arteries, there is less room for blood to flow. Every part of your body needs blood that is rich in oxygen. But plaque buildup prevents that blood from flowing freely and starves the muscles and other tissues in the lower body.
What are the symptoms?
Many people who have PAD don't have any symptoms.
But if you do have symptoms, you may have a tight, aching, or squeezing pain in the calf, thigh, or buttock. This pain, called intermittent claudication, usually happens after you have walked a certain distance. For example, your pain may always start after you have walked a block or two or after a few minutes. The pain goes away if you stop walking. As PAD gets worse, you may have pain in your foot or toe when you aren't walking.
How is PAD diagnosed?
Your doctor will talk with you about your symptoms and past health and will do a physical exam. During the exam, your doctor will check your pulse at your groin, behind your knee, on the inner ankle, and on the top of your foot. Your pulse shows the strength of blood flow. An absent or weak pulse in these spots is a sign of PAD. Your doctor may also look at the color of your foot when it is higher than the level of your heart and after exercise. The color of your foot can be a clue to whether enough blood is getting through your arteries.
You will likely have a test that compares the blood pressure in your legs with the blood pressure in your arms. This test is called an ankle-brachial index. A test called an arterial Doppler ultrasound may be done to check the blood flow in your arteries.
Blood tests to check your cholesterol and blood sugar can tell whether you may have other problems related to PAD, such as high cholesterol and diabetes.
How is it treated?
Treatment for PAD relies mainly on healthy lifestyle changes and taking care to manage high blood pressure and cholesterol. You may need medicines to ease symptoms or to manage other health problems. In some cases, you may need surgery or a procedure called angioplasty.
When you have PAD, you have a high risk of having a heart attack or stroke. Making healthy changes can help reduce this risk.
Lifestyle changes
- If you smoke, quit. It's one of the most important things you can do. If you need help, talk to your doctor about programs and medicines that can help you stop.
- Eat healthy foods.
- Follow an exercise program.
- Manage your cholesterol and blood pressure if they are high. You may need medicines to help you do this.
- If you have diabetes, keep your blood sugar in a target range.
- Lose weight if you need to, and maintain a healthy weight.
Your doctor may suggest that you attend a cardiac rehabilitation (rehab) program. In cardiac rehab, you will get education and support to help you make new, healthy habits.
Medicines and surgery
If lifestyle changes don't help, your doctor may prescribe a medicine that may relieve the pain when you walk.
For severe PAD, you may need a procedure called angioplasty or bypass surgery to open narrowed arteries or to reroute blood flow around them.
In rare cases, advanced PAD can cause tissues in the leg or foot to die because they don't get enough oxygen as a result of poor blood flow. If this happens, part of the leg or foot must be removed (amputated). This is more common in people who also have diabetes.
Health Tools
Health Tools help you make wise health decisions or take action to improve your health.
|Decision Points focus on key medical care decisions that are important to many health problems.
|Peripheral Arterial Disease: Should I Have Surgery?
|Actionsets are designed to help people take an active role in managing a health condition.
|Healthy Eating: Eating Heart-Healthy Foods
Frequently Asked Questions
Learning about peripheral arterial disease (PAD) of the legs:
Being diagnosed:
Getting treatment:
Living with PAD:
The most common cause of peripheral arterial disease is the buildup of plaque on the inside of arteries. Plaque is made up of excess cholesterol, calcium, and other substances in your bloodstream. Over time, plaque builds up along the inner walls of the arteries, including the arteries that feed your legs. The plaque deposits decrease the space through which oxygen- and nutrient-rich blood can flow. Poor blood flow "starves" the muscles and other tissues in the lower body.
This process of plaque buildup—called atherosclerosis or "hardening of the arteries"—usually happens throughout the body, including the leg arteries, coronary arteries, and carotid arteries.
Atherosclerosis gradually develops over a lifetime. High cholesterol, high blood pressure, and smoking contribute to atherosclerosis and peripheral arterial disease.
In very rare cases, peripheral arterial disease can be unrelated to atherosclerosis and caused instead by inflammation of the blood vessels (vasculitis) and old injuries that damaged blood vessels.
Many people who have peripheral arterial disease (PAD) don't have symptoms.
If you do have symptoms, you may have a tight, aching, or squeezing pain in your calf, thigh, or buttock. This pain, called intermittent claudication, usually happens after you have walked a certain distance.
For example, your pain may always start after you have walked a block or two or after a few minutes. The pain goes away if you stop walking. As PAD gets worse, you may have pain in your foot or toe when you aren't walking.
Only about 1 out of 5 people with PAD have intermittent claudication.1
Other symptoms of peripheral arterial disease of the legs may include:
- Weak or tired legs.
- Difficulty walking or balancing.
- Cold and numb feet or toes.
- Sores that are slow to heal.
- Foot pain while you are at rest, which means that PAD is getting worse.
- Erectile dysfunction .
- Pain in the thighs, hips, and buttocks. These symptoms may be caused by Leriche's syndrome, a type of PAD.
More severe symptoms, such as skin changes on the feet or legs, may be a sign of advanced PAD.
Some people may not report symptoms to their doctors. This may happen in:
- People who have a high pain tolerance.
- People who have other health problems such as diabetes with numbness in their legs. This can prevent them from feeling pain.
- People who never exert themselves long enough for leg pain to start.
Whatever the reason, not reporting symptoms can make it harder for doctors to diagnose the disease.
What Increases Your Risk
Many things can increase your risk for atherosclerosis and peripheral arterial disease (PAD). These include:
- Smoking.
- High cholesterol.
- High blood pressure.
- Diabetes. People with diabetes often have arterial disease that is both more severe and more widespread than in people who don't have diabetes.
- A family history of atherosclerosis or coronary artery disease.
The risk for PAD also increases with age. About 1 out of 5 adults older than 55 have peripheral arterial disease (PAD).2
People who have the disease in one part of the body are likely to have it in other places, including the legs.
When to Call a Doctor
Call your doctor immediately if you suddenly have severe leg pain; numbness; or pale, blue-black skin.
Call your doctor if you have:
- Leg pain that begins after you walk a certain distance and that goes away when you rest (intermittent claudication).
- Foot or toe pain when you are resting.
Who to see
Health professionals who may be involved in the diagnosis and treatment of peripheral arterial disease (PAD) include:
- Family medicine doctor .
- Internal medicine doctor (internist).
- Cardiologist .
- Vascular surgeon .
Exams and Tests
If your doctor thinks that you may have peripheral arterial disease (PAD), he or she will examine you for physical signs of the disease and will ask about your personal and family medical history. This is a good time to talk with your doctor about any symptoms you have noticed.
Diagnostic tests
Tests you may have to confirm PAD include:
- Pulse and blood pressure checks in different areas of your body. Your doctor may also look at the color of your foot when it is elevated and after you exercise.
- Ankle-brachial index (ABI) test. This test helps find out how narrow your arteries are. It can also measure blood flow through the arteries.
- Doppler ultrasound. It may be used instead of the ankle-brachial index to measure blood flow in the arteries.
- Magnetic resonance angiogram (MRA) or computerized tomography (CT) angiography. These tests can also help diagnose PAD.
Tests for other health problems
Your doctor may also do other tests to find out if you have health problems that can cause PAD or make it worse. When you have PAD, you are at high risk for coronary artery disease, heart attack, and stroke. You may have tests for:
- Cholesterol.
- Blood pressure .
- Blood glucose, which tests for diabetes.
Treatment Overview
Your treatment for peripheral arterial disease (PAD) will focus on healthy lifestyle changes first. You may need to take medicines to ease leg pain or to help you manage other health problems.
If lifestyle changes don't help, or if your PAD gets very bad, you may need angioplasty or bypass surgery of the leg arteries.
It's important to do what you can to improve your health and possibly reverse the buildup of plaque in your arteries. When you have PAD, you have a high risk of having a heart attack or stroke. Making healthy changes and following your treatment plan can reduce this risk.
Healthy changes you can make
- If you smoke, quit. Quitting is the best thing you can do when you have peripheral arterial disease (PAD). Medicines and counseling can help you quit for good.
- Try to get more exercise. Studies show that walking 3 times a week for 3 to 6 months lengthens the distance you can walk before you need to stop because of leg pain.3 Being able to walk farther may mean that you are getting better blood flow to the muscles in your legs. A supervised exercise program that is designed just for you may help you the most.
- Eat heart-healthy foods, such as fruits and vegetables.
A cardiac rehab program can help you make lifestyle changes. In cardiac rehab, a team of health professionals provides education and support to help you make new, healthy habits.
See Living With PAD for more ideas about changes you can make and about support to help you make them.
You may need medicines to help prevent blood clots, improve cholesterol, or lower blood pressure. You might take a medicine that can help ease pain while you are walking.
Procedures and surgery
Sometimes peripheral arterial disease gets worse despite treatment. People who have severe PAD or who are at risk for losing a limb may need bypass surgery or other procedures (such as angioplasty) to restore proper blood flow to the legs.
You can prevent or delay peripheral arterial disease (PAD) by controlling risk factors and changing your lifestyle. See Living With PAD for ideas and support.
Living With PAD
There are many things you can do to keep peripheral arterial disease (PAD) from getting worse. These steps may also help lower your blood pressure and cholesterol, which can help control PAD.
And doing any one of these things can help you reduce your risk of heart attack and stroke, which is important to do when you have PAD.
Focus on a healthy lifestyle
- Quit smoking and avoid secondhand smoke. Smoking is a major risk factor for peripheral arterial disease. Quitting smoking may help prevent PAD or slow its progression. For more information on how to stop smoking, see the topic Quitting Smoking.
- Follow a walking program or other regular exercise, and consider adding weight training too.
- Stay at a healthy weight.
- Eat heart-healthy foods, such as fruits and vegetables.
- If you have diabetes, keep your blood sugar in your target range.
- Avoid getting sick from the flu. Get a flu shot every year.
A cardiac rehab program can help you make lifestyle changes. In cardiac rehab, a team of health professionals provides education and support to help you make new, healthy habits.
Care for your feet and legs
Take good care of your feet and legs. When you have reduced blood flow to your legs, even minor injuries can lead to serious infections.
- Treat wounds, cuts, and scrapes on your legs right away. Poor blood flow to the legs caused by PAD can keep wounds, cuts, and scrapes from healing properly. Prompt treatment can help you avoid this problem and is especially important for people who also have diabetes.
- Avoid shoes that are too tight or that rub your feet. Shoes should be comfortable and fit well. Avoid socks or stockings that are tight enough to leave elastic-band marks on your legs. They can make circulation problems and symptoms from PAD worse.
- Keep your feet clean and moisturized to prevent your skin from drying and cracking. Place cotton or lamb's wool between your toes to prevent rubbing and to absorb moisture.
- If open sores form, keep them dry and cover them with nonstick bandages. See your doctor as soon as you discover an open sore.
Medicines are used to treat symptoms of peripheral arterial disease (PAD) or to help manage other health problems that can raise your risk of heart attack and stroke.
Medicine choices
- Aspirin and other antiplatelet medicines to help lower the risk of heart attack and stroke.
- Statins to help lower cholesterol levels.
- Medicines to control high blood pressure.
- Medicines to control diabetes.
- Cilostazol (Pletal) to treat leg pain that comes on with activity (intermittent claudication).
Most of the time, surgery is only done in cases of severe peripheral arterial disease (PAD), such as disabling intermittent claudication; open sores (ulcers that won't heal); or serious skin, bone, and tissue problems (gangrene).
Bypass surgery redirects blood through a grafted blood vessel to bypass the blood vessel that is damaged. The grafted blood vessel may be a healthy natural vein or artery, or it may be man-made.
The methods of bypass surgery vary depending on the size of the affected artery and where it is located.
Surgery choices
The type of surgery used to treat PAD will depend on the location of the affected leg artery or arteries.
- Aortobifemoral bypass is done for PAD that affects the major abdominal artery (aorta) and the large arteries that branch off of it.
- Femoropopliteal (fem-pop) bypass is done for PAD that affects the arteries above and below the knee.
- Femoral-tibial bypass is done for PAD that affects the arteries arteries in the lower leg or foot.
Endarterectomy is a less common surgery. It is typically done on the large femoral artery, which is in your groin and upper thigh area.
This surgery is done to remove fatty buildup (plaque) and to increase blood flow to the leg. This surgery is done by cutting open the femoral artery and removing the plaque. This surgery may be done by itself, or it may be done at the same time as bypass surgery or angioplasty.
What to think about
In rare cases, peripheral arterial disease gets so bad that some people need to have a leg, a foot, or part of the foot amputated. People with diabetes are at increased risk for amputation. Amputation is used only when the damage is very severe, possibly life-threatening, and after all other treatment options have been tried.
Also in rare cases, a blood clot in an artery can suddenly and completely block blood flow to a leg or foot. Often, severe pain, numbness, and coldness develop within 1 hour. This blockage is an emergency. Clot-dissolving medicines, surgical removal of the clot, or bypass surgery is needed to restore blood flow.
Other Treatment
Angioplasty is used for severe disease that causes pain and limping during exercise, pain when at rest, or open sores. It works best in larger arteries, where it is used to increase blood flow in a narrowed artery.
During this procedure, a small, thin tube called a catheter is inserted through a blood vessel in the groin and guided to the affected artery. When the catheter reaches the narrowed part of the artery, the surgeon inflates a balloon. The balloon presses the plaque against the wall of the artery. This improves blood flow.
A small, expandable tube called a stent may be placed in a blood vessel to help hold it open.
Complementary and alternative medicine
Alternative treatments, such as ginkgo biloba and carnitine, might help leg pain and may improve how well you can walk. But these are not proven treatments and may not work for everyone.
Other Places To Get Help
|Society for Interventional Radiology
|3975 Fair Ridge Drive
|Suite 400 North
|Fairfax, VA 22033
|Web Address:
The Society of Interventional Radiology is a national organization of physicians, scientists, and health professionals dedicated to improving public health through disease management and minimally invasive, image-guided therapies. Intervention radiology includes using X-rays, MRI, and other imaging to move a thin tube in the body, usually in an artery, to treat a disease. An example is angioplasty for heart disease. The Web site includes a section on patient information. This section gives information on therapies for various diseases and conditions. The Web site can also help you find a doctor.
|American Heart Association (AHA)
|7272 Greenville Avenue
|Dallas, TX 75231
|Web Address:
Visit the American Heart Association (AHA) website for information on physical activity, diet, and various heart-related conditions. You can search for information on heart disease and stroke, share information with friends and family, and use tools to help you make heart-healthy goals and plans. Contact the AHA to find your nearest local or state AHA group. The AHA provides brochures and information about support groups and community programs, including Mended Hearts, a nationwide organization whose members visit people with heart problems and provide information and support.
|HeartHub for Patients
|Web Address:
HeartHub for Patients is a website from the American Heart Association. It provides patient-focused information, tools, and resources about heart diseases and stroke. The site helps you understand and manage your health. It includes online tools that explain your risks and treatment options. The site includes articles, the latest news in health and research, videos, interactive tools, forums and community groups, and e-newsletters.
The website includes health centers that cover heart rhythm problems, cardiac rehabilitation, caregivers, cholesterol, diabetes, heart attack, heart failure, high blood pressure, peripheral artery disease, and stroke.
HeartHub for Patients also links to Heart360.org, another American Heart Association website. Heart360 is a tool that helps you send and receive medical information with your doctor. It also helps you monitor your health at home. It gives you access to tools to manage and monitor high blood pressure, diabetes, high cholesterol, physical activity, and nutrition.
|National Heart, Lung, and Blood Institute (NHLBI)
|P.O. Box 30105
|Bethesda, MD 20824-0105
|(301) 592-8573
|(240) 629-3246
|(240) 629-3255
|Web Address:
The U.S. National Heart, Lung, and Blood Institute (NHLBI) information center offers information and publications about preventing and treating:
|Society for Vascular Surgery
|633 North Saint Clair Street, 24th Floor
|Chicago, IL 60611
|Web Address:
VascularWeb is a Web site provided by the Society for Vascular Surgery. This Web site provides information about vascular conditions for patients and families. VascularWeb can help you learn about how to prevent and treat vascular diseases, learn about vascular screening, and find a vascular surgeon.
Related Information
- White C (2007). Intermittent claudication. New England Journal of Medicine, 356(12): 1241–1250.
- Cassar K (2011). Peripheral arterial disease, search date May 2010. Online version of BMJ Clinical Evidence: http://www.clinicalevidence.com.
- Hirsch AT, et al. (2006). ACC/AHA 2005 practice guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): A collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation. Circulation, 113(11): e463–e654.
Other Works Consulted
- Alonso-Coello P, et al. (2012). Antithrombotic therapy in peripheral artery disease: Antithrombotic therapy and prevention of thrombosis, 9th ed.—American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 141(2, Suppl): e669S–e690S.
- Creager MA, et al. (2008). Atherosclerotic peripheral vascular disease symposium II: Executive summary. Circulation, 118(25): 2811–2825.
- Creager MA, Libby P (2012). Peripheral arterial diseases. In RO Bonow et al., eds., Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 9th ed., vol. 2, pp. 1338–1358. Philadelphia: Saunders Elsevier.
- Fowkes F, Leng GC (2008). Bypass surgery for chronic lower limb ischaemia. Cochrane Database of Systematic Reviews (2).
- Hirsch J, et al. (2008). Executive summary: American College of Chest Physicians evidence-based clinical practice guidelines (8th ed.). Chest, 133(6): 71S–109S.
- National Heart, Lung, and Blood Institute (2006). Your Guide to Lowering Your Blood Pressure With DASH (NIH Publication No. 06-4082). Available online: http://www.nhlbi.nih.gov/health/public/heart/hbp/dash/new_dash.pdf.
- Norgren L, et al. (2007). Inter-society consensus for the management of peripheral arterial disease (TASC II). European Journal of Vascular Surgery, 33 (Suppl 1): S1–S70.
- Olin JW, et al. (2010). ACCF/AHA/ACR/SCAI/SIR/SVM/SVN/SVS 2010 Performance measures for adults with peripheral artery disease. Journal of the American College of Cardiology, 56(25): 2147–2181.
- Rooke TW, et al. (2011). 2011 ACCF/AHA Focused update of the guideline for the management of patients with peripheral artery disease (updating the 2005 guideline): A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology, 58(19): 2020–2045.
- Smith SC, et al. (2011). AHA/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update: A guideline from the American Heart Association and American College of Cardiology Foundation. Circulation, 124(22): 2458–2473. Also available online: http://circ.ahajournals.org/content/124/22/2458.full.
- U.S. Preventive Services Task Force (2005). Screening for peripheral arterial disease. Available online: http://www.uspreventiveservicestaskforce.org/uspstf/uspspard.htm.
- U.S. Preventive Services Task Force (2009). Aspirin for the prevention of cardiovascular disease. Available online: http://www.uspreventiveservicestaskforce.org/uspstf/uspsasmi.htm.
- Wennberg PW, Rooke TW (2011). Diagnosis and management of diseases of the peripheral arteries and veins. In V Fuster et al., eds., Hurst's The Heart, 13th ed., vol. 2, pp. 2331–2346. New York: McGraw-Hill.
|Healthwise Staff
|Primary Medical Reviewer
|Rakesh K. Pai, MD, FACC - Cardiology, Electrophysiology
|Specialist Medical Reviewer
|David A. Szalay, MD - Vascular Surgery
|Last Revised
|May 17, 2012
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Last Revised: May 17, 2012
Author: Healthwise Staff
Medical Review: Rakesh K. Pai, MD, FACC - Cardiology, Electrophysiology & David A. Szalay, MD - Vascular Surgery
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Musaic Box: Hidden Object
by HeroCraft Ltd
Download this app if: you like music-based puzzlers.
Developer Notes
Test yourself in this unique game of a totally new genre – a hidden objects musical quest.
PC version won Independent Game Festival in 2009 and got the award "Excellence in Game Design".
Musaic Box is an unusual combination of musical puzzle and a detective quest. Its scenario offers you a...
Musical — Unusual puzzle game where you'll need a musical ear to be successful.