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Cell cycle checkpoints are control mechanisms that ensure the fidelity of cell division in eukaryotic cells. These checkpoints verify whether the processes at each phase of the cell cycle have been accurately completed before progression into the next phase. Multiple checkpoints have been identified, though some of them are less understood than others
An important function of many checkpoints is to assess DNA damage, which is detected by sensor mechanisms. When damage is found, the checkpoint uses a signal mechanism either to stall the cell cycle until repairs are made or, if repairs cannot be made, to target the cell for destruction via apoptosis (effector mechanism). All the checkpoints that assess DNA damage appear to utilize the same sensor-signal-effector mechanism.
The cell cycle, according to Temple and Raff (1986),[1] was expected to function as a clock; but, if this were the case, it would be expected that the stages of the cell cycle must function according to some sort of internal clock, which would determine how long a phase should last. However, the cell cycle is now depicted as falling dominoes: The preceding phase has to "fall" before the next phase can begin. The cell cycle checkpoints are, therefore, made up of composites of protein kinases and adaptor proteins that all play salient roles in the maintenance of the cell division's integrity.
The DNA damage checkpoint is always active. Nonetheless, most human cells, for example, are terminally differentiated and must exit the cell cycle. There is a phase late in G1 phase called the restriction point (RP, or the restriction checkpoint); cells that should cease division exit the cell cycle and enter G0. Cells that continually divide in the adult human include hematopoietic stem cells and gut epithelial cells. Therefore, the re-entrant into the cell cycle is possible only by overcoming the RP. This is achieved by growth factor-induced expression of cyclin D proteins. These then overcome the G0 barrier and are able to enter the cell cycle.
The main checkpoints that control the cell division cycle in eukaryotes include:
The first checkpoint is located at the end of the cell cycle's G1 phase, just before entry into S phase, making the key decision of whether the cell should divide, delay division, or enter a resting stage. Many cells stop at this stage and enter a resting state called G0. Liver cells, for instance, enter mitosis only around twice a year.[citation needed] The G1 checkpoint is where eukaryotes typically arrest the cell cycle if environmental conditions make cell division impossible or if the cell passes into G0 for an extended period. In animal cells, the G1 phase checkpoint is called the restriction point, and in yeast cells it is called the Start point.
The restriction point is controlled mainly by action of the CKI p16 (CDK inhibitor p16). This protein inhibits CDK4/6 and ensures that it can no longer interact with cyclin D1 to cause cell cycle progression. In growth-induced or oncogenic-induced cyclin D expression, this checkpoint is overcome because the increased expression of cyclin D allows its interaction with CDK4/6 by competing for binding. Once active CDK4/6-cyclin D complexes form, they phosphorylate the tumor suppressor retinoblastoma protein (Rb), which relieves the inhibition of the transcription factor E2F. E2F is then able to cause expression of cyclin E, which then interacts with CDK2 to allow for G1-S phase transition. This brings the cell to the end of the first checkpoint, signaling the G0-G1-S-phase transition.
In simpler terms, the CDK inhibitor p16 inhibits another CDK from binding to its cyclin (D). When growth is induced, the expression of this cyclin is so high that they do bind. The new CDK/cyclin complex now phosphorylates retinoblastoma (a tumor suppressor). Phosphorylated retinoblastoma releases the inhibition of a transcription factor. This factor then brings about the G1-S phase transition.
The second checkpoint is located at the end of G2 phase, triggering the start of the M phase (mitotic phase). In order for this checkpoint to be passed, the cell has to check a number of factors, such as DNA damage via radiation, to ensure the cell is ready for mitosis. If this checkpoint is passed, the cell initiates the many molecular processes that signal the beginning of mitosis. The CDKs associated with this checkpoint are activated by phosphorylation of the CDK by the action of a "Maturation promoting factor" (Mitosis Promoting Factor, MPF).
The molecular nature of this checkpoint involves an activating phosphatase, known as Cdc25, which under favorable conditions removes the inhibitory phosphates present within the MPF (term for the cyclin B/CDK1 complex). However, DNA is frequently damaged prior to mitosis, and, to prevent transmission of this damage to daughter cells, the cell cycle is arrested via inactivation of the Cdc25 phosphatase. This is done by the ATM kinase protein which phosphorylates Cdc25 which leads to its ubiquitinylation and destruction. The same conditions that cause inactivation of cdc25 also cause activation of Wee1, a protein which phosphorylates cdk1 at Tyrosine 15 (the Tyrosine residue that must be dephosphorylated for the cdk to be activated).
The mitotic spindle checkpoint occurs at the point in metaphase where all the chromosomes should/have aligned at the mitotic plate and be under bipolar tension. The tension created by this bipolar attachment is what is sensed, which initiates the anaphase entry. To do this, the sensing mechanism ensures that the anaphase-promoting complex (APC/C) is no longer inhibited, which is now free to degrade cyclin B, which harbors a D-box (destruction box), and to break down securin.[2] The latter is a protein whose function is to inhibit separase, which in turn cuts the cohesins, the protein composite responsible for cohesion of sister chromatids.[3] Once this inhibitory protein is degraded via ubiquitination and subsequent proteolysis, separase then causes sister chromatid separation.[4] After the cell has split into its two daughter cells, the cell enters G1.
Prophase, metaphase, anaphase, telophase are the steps of mitoisis.


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From the Ashes | Mary's Farm
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When I came of age, my older cousin Mac taught me to drive stick shift on this car and also how to work the choke–a tricky business. Mac used the car all through his college years, used it as the "getaway" car after his wedding, and carried it onward into his life. Eventually, the car went into storage, a polite way of saying that it disintegrated into pieces in a pile in Mac's barn. The years passed. We all felt heartsick to see such a sad sight. We almost forgot it was there. But somehow Mac's daughter, Hayden, didn't forget the OGF, though it's a mystery to me how she remembered it, since she wasn't old enough to have ever known it as a living, driving, moving being. Still, she was planning her wedding and said to her father one day, "I'd love to be able to drive away from my wedding in the OGF!"
And so it was last May that I accompanied Mac to a place called RMR Restorations in Hollis, New Hampshire, not far from my home, where men who know about such things indulge in the act of resurrection. Buckets of rusted parts were wheeled in. From their long storage, the chassis and a couple of doors were brought up on a flatbed truck. I entered the operating room with trepidation. In the OGF resided a deep well of emotion I hadn't visited in many years. Of all the rusty pieces before me, I could identify only the steering wheel and the hubcaps. We told the mechanics the story of the car's life in our family. Standing in a quiet semicircle, the men listened respectfully. Then we left them to their magic, which they performed over the next five months.
In October, on the beautiful blue-sky day of Hayden's wedding, a shining OGF sat beside a house by the sea. The gray paint gleamed like polished enamel. A red pinstripe ran the length of the car to the rear fender. The hubcaps were like mirrors. We all hovered around it, feeling a bit as though we were seeing a ghost, touching the imagined. Suddenly, we were afraid of leaving fingerprints on this vehicle that we used to treat like a comfortable old shoe.
I climbed into the passenger seat. The car smelled of leather and hot sun. Mac worked the choke and pumped the accelerator; the engine rumbled to life. He pressed the gearshift into first, and we moved out onto the road. As I thought about a young soldier who'd gone to war and never come back, about my mother, who couldn't bring herself to drive this car, about the years and the sheer will that had kept the OGF alive–or on life support–that well of emotion overflowed. The wedding was picture-perfect. Of course. The Old Gray Ford was with us.

subset: commoncrawl


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glucose [%PREMIUM_LINK%] (gl'kōs') Pronunciation Key A monosaccharide sugar found in plant and animal tissues. Glucose is a product of photosynthesis, mostly incorporated into the disaccharide sugar sucrose rather than circulating free in the plant. Glucose is essential for energy production in animal cells. It is transported by blood and lymph to all the cells of the body, where it is metabolized to form carbon dioxide and water along with ATP, the main source of chemical energy for cellular processes. Glucose molecules can also be linked into chains to form the polysaccharides cellulose, glycogen, and starch. Chemical formula: C6H12O6. See more at cellular respiration, Krebs cycle, photosynthesis. |
Dictionary.com presents 366 FAQs, incorporating some of the frequently asked questions from the past with newer queries.


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When you're filling out your wish-list of wedding gifts, don't forget to include supplies for the garden shed. With the right... Read more »
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Adding a small photo charm to a bride's bouquet is a touching way for a bride to remember someone special on her wedding day. Read more »
Making your own wedding veil is easier than you think. Read more »
DIY your bridesmaid's hair accessories create beautiful embellishments that will compliment your wedding's themes and style wh... Read more »
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1) How long have you been crafting?
Since 1995.
2) Why did you start crafting?
Right after I was married, I created a scrapbook for our wedding. Then I started dabbling in other paper crafts. Crafting makes me happy!
3) How long have you been on the Fiskars® Design Team?
I am new (as of July 2012)! This is a new, creative adventure for me.
4) What are your favorite craft activities?
My first love will always be scrapbooking. But I love making cards, crafting with my kids, and I enjoy creating mixed-media projects.
5) How do you define your crafting style/aesthetic?
My style is pretty simple. I like to craft quick, and I try to be adventurous with new techniques. If I am scrapbooking, my photos and writing are important. There is always a little paint, ink, & glitter in the mix.
6) What is your favorite time of day to craft?
I love to craft any chance I get. My most favorite time is late into the night.
7) What motivates/inspires you?
I am inspired by creative friends, amazing graphic design, and a great photo. I am motivated by red vines licorice & sour patch kids.
8) If you could only have one Fiskars® tool, what would it be and why?
My 12" portable trimmer. I have updated it, yet have used a Fiskars trimmer since the beginning!
To follow Kim's adventures in crafting check out her blog: www.kimgarner.blogspot.com
Halloween is a great time for dressing up, and deciding what you want to be for Halloween is a big deal for kids. For some, it is hard to decide.
Here is a quick and easy craft the kids can create for their teacher gifts this year using a pencil eraser as a stamp.
Grab a notebook, a few photos, a glue stick, and a pen. Add a few fun embellishments and you have what you need to create the perfect summer journal!
There are not enough ways to tell those who serve our country "thank you".
I created these yarn-wrapped wreaths to cover old frames that held my grandmother's cross-stitch Christmas ornaments. This way, I turned some special, handmade ornaments into new again!
Yearly photo ornaments are a fun way to see how over time people change.
Many times I forget about some of the products that I have purchased for my creative projects.
Try out the new Fuse Mini Dies as you create a carefree and easy scrapbook layout!
Using paper ephemera from the past, gives your present projects a new style and dimension that you may have never found before.
Photos, photos, photos! Now that we live in a digital age, we have so many photos of every event.
When you look through recent scrapbook designs, there are the usual shapes that you see: circles, squares, triangles, etc. But recently, there is a new geometric shape that is taking the paper crafting world by storm: hexagons....
My two favorite things: reading and crafting. Here are a few projects to ignite your (and your kid's) love of books.
By challenging yourself to use three or more mediums, you can begin to create beautiful mixed-media scrapbooking projects.
A handmade card or gift box for the wedding couple, adds just a special touch of thoughtfulness that is better than store bought cards.


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Features Subscribe to Features
Gautam advise Muslims to develop relationship with non-Muslims
Muhammad Umar Gautam, Chairman, Islamic Da'wah Centre, New Delhi, who embraced Islam in 1984, was on a week's visit to the city and left on Feb. 9. He was accompanied… Read more
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Prof. Dr. Rank Nazeer Ahmed* Summary: The common perception is that the religious minorities in Karnataka are rapidly closing the education gap. However, a detailed statistical analysis of data for… Read more
Analyzing without suggesting solutions
By, Gulame Ghouse Good intentions and sermons do not solve our problems. They should be backed up by field work and continuous struggle. The field work can be done by… Read more
Was Tipu really secular?
By, N A Lohani These days, there is a lot of hue and cry over the establishment of a University in the name of the 18th century Muslim ruler Tipu… Read more
Best way to celebrate Milaad-un-Nabi
Dr. Rokhiya Jaferi Siddique According to the most Muslim historians, the birth of Prophet Mohammed (pbuh) can be traced back to April 20, 571 AD. His exact date of birth… Read more
Why BJP is losing temper on Tippu's name
By Mohammed Ahmed Khan* Patriotism originated in India, the 'sign of paradise' only during its British occupation. This feeling was not there during the Mughal rule or for that sake… Read more
How safe is India for women?
Every 20 minutes a daughter of India is robbed off her modesty; the hike in the pace is just three fold over a decade; it was one in 54 minutes… Read more
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By Sheema Mohsin Women constitute about one half of the global population but they are placed in various disadvantageous positions due to gender differences and bias. For centuries they have… Read more
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By Moulana Waheeduddin Khan, Umari and Madani Apparently the atmosphere is against Islam across the world today. But its increasing influence and the Arab Spring indicate the effectiveness of… Read more
One dervish, one roti, four urchins
Dr. Nazeer Ahmed They called him Shah, the king, even though he was a dervish who owned nothing. Legend had it that one of his forefathers, a certain God-fearing Shaikh,… Read more


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AP Pro32 comments about Vikings
Comments on the Minnesota Vikings by the AP Pro32 panel (ranking in parentheses):
Chris Berman (ESPN, 10) - Congrats to Adrian Peterson on an amazing game and season. Congrats to the Vikings on going from three wins to 10.
Clifton Brown (Sporting News, 9) - The remarkable Adrian Peterson gets another crack at the Packers.
Cris Collinsworth (NBC Sports, 11)
Rich Gannon (CBS Sports/SiriusXM NFL Radio, 11) - Can Adrian Peterson do it again on a short week against the Packers? Charles Woodson back for GB is huge because he's their best tackler.
Bob Glauber (Newsday, 8) - Adrian Peterson with one of the greatest comebacks ever, and nearly breaks Eric Dickerson's record on the way to clinching a playoff berth for the Vikes. A mind-boggling season after ACL surgery.
Rick Gosselin (Dallas Morning News, 12) - Adrian Peterson finished nine yards short of the NFL single-season rushing record but couldn't have drawn a more favorable opponent in the playoffs than the Packers. He rushed for 210 and 199 yards in his two games against them this season.
Clark Judge (CBSSports.com, 9) - Now starring in the Miracle Worker, Part II: Adrian Peterson and Leslie Frazier.
Ira Kaufman (Tampa Tribune, 11) - It will be challenging for Christian Ponder to keep his cool at frosty Lambeau.
Pat Kirwan (SiriusXM NFL Radio/CBSSports.com, 10) - Adrian Peterson ran his team into the playoffs which many thought couldn't be done. The defense is underrated and rookie kicker, Blair Walsh is a great weapon.
John Lynch (Fox Sports, 12) - AP continues to amaze! Can they go into Lambeau and repeat their magical victory from last week?
Alex Marvez (Foxsports.com, 9) - Adrian Peterson finished 9 yards short of breaking Eric Dickerson's single-season rushing record, but leading Minnesota into the playoffs is a nice consolation prize.
Dan Pompei (Chicago Tribune, 6) - If Christian Ponder plays like he did Sunday in the playoffs, the Vikings can go all the way.
http://pro32.ap.org/poll and http://twitter.com/AP-NFL
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Falcons hire former Chiefs GM Pioli as assistant general manager


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Advances in Dental Research
Publisher: The International & American Associations for Dental Research
Advances in Dental Research® provides a forum for detailed exploration
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The Journal seeks to publish (i) brief definitive reports of wide
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Email: firstname.lastname@example.com
Online issue nonmember subscription rates: $25.00/issue.
All issues are available free of charge 12 months after the publication date.
Current Issue: May 2002
Date: 15 April 2004


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Black & Decker is recalling about 200,000 grass trimmers because of safety concerns. The Consumer Product Safety Commission says over 150 people have been hurt by the Black & Decker GH1000 Grasshog XP String Trimmer/Edgers.
The trimmer's spool, spool cap and pieces of trimmer string can come loose during use and become airborne projectiles, posing a serious laceration hazard to the user, as well as bystanders. The trimmers can also overheat, posing a burn hazard to consumers.
The trimmers are electric-powered. Trimmers with black spool caps and date codes 00546 through 200645 are included in this recall. Those with orange spool caps are not included in the recall.
The trimmers were sold at major home center and hardware stores nationwide from November 2005 through January 2007 for about $70.
Consumers should stop using the string trimmers immediately and contact Black & Decker for a free repair kit.


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The Huffington Post
Thomas R. Eisenmann, Toby Stuart, David Kiron
Revision Date:Oct 06, 2010Publication Date:Mar 29, 2010Discipline:EntrepreneurshipSource:Harvard Business School |
Product number:810086-PDF-ENG Length:22p |
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In Feb. 2010, management of the Huffington Post, a fast-growing but not-yet-profitable Internet newspaper that aggregates blog posts from unpaid contributors and excerpts of stories originally published by other news sites, faces a number of decisions about its growth strategy. Foremost, Huffington Post management must determine whether to rely to a greater extent upon social networking technologies (e.g., Facebook, Twitter) to select and present the content delivered to specific users or continue to rely on human editors to play a curator role.
learning objective:
Build students' skill in evaluating business models and their understanding of trade-offs confronting entrepreneurs as they consider growth strategy options.
subjects covered:
Business models; Entrepreneurship; Growth strategy; Internet
- Geographic: United States
- Industry: Newspaper publishing
- Company Employee Count: 135
- Company Revenue: $12m
- Event Year Begin: 2010


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Company Profile |
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We enjoyed our stay in this hotel. In the center of Bergamo Alta. Good food. Clean room. Got free parking. - Anonymous
Very nice designed hotel in excellent location in upper town! The room even the standard one is big enough with everything you need. - Anonymous
Excellent location, studio equipped with everything one may need during the stay (they even have a washing machine and hair straightener!), parking facilities, modern design, balcony with great view, plus, a friendly landlady. Pictures don't actually reflect the charm of the place, the studio's way better than the photos show. Will come back for sure while in Bergamo again. - Anonymous
Wonderful rooms in a stone building in the centre of the old town. Perfect location. Gianmauro is a dedicated host who will make everything in his power to make your stay a memorable holiday. Easy and fast transportation to the airport and railway station (also if you choose local bus). A safe choice for our next visit in Bergamo. - Anonymous
A beautifully converted palazzia - all modern amenieties in a beautiful old building. The hotel even provided parking vouchers for a nearby square - excellent service! - Peter
It's great! Small family hotel in the heart of the pictoresque medieval town (Bergamo- Alta) with just few minutes walking distance from main square. Cosy rooms in old- style interiors, owners hospitality, unique location make a stay in Bergamo unforgettable! Thanks Simnona and Gigi for care, wish to recommend this place to those who want to feel a spiriy of old Bergamo. - Anonymous
I saw this hotel every time during my 4 previous trips to Bergamo... always thinking it must be wonderful to stay in such central point, on the middle way between funicolare upper station and Duomo... with great fontain on small square... And this time I found super last minute offer, only 55 euro for twin room with private bathroom and breakfast. I could not resist! And it was GREAT. Very very nice staff, clean, with good free wifi internet in reception area and with enormous (for Italy at lea - Anonymous
Arranged a lift from airport with hotel owner - very friendly and meant we could get in to the room very early. Beautiful old building - lively location in the historical centre of bergamo. Within walking distance of all the important sites in the old town and funicular for bergamo basso. Rooms massive and well presented, bathrooms too! Very friendly and welcoming staff. Breakfast good with platter of fresh fruit, hot drinks, meat and cheeses, yoghurts and bread. - Anonymous
A very very ancient house with many collections by the host, Marko. Marko is a nice guy, friendly and very helpful. - Anonymous


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The reprogramming of skin fibroblasts into pluripotent stem (iPS) cells represents a significant milestone towards the goal of developing stem cell therapies tailored to the patient. However, the reprogramming is slow and inefficient. A key step is the ability of four exogenously introduced transcription factors to turn on or activate the endogenous versions of their own genes, a process termed autoregulation. In fibroblasts, the genes for the endogenous transcription factor genes are turned off because they are assembled into a repressive structure termed silent chromatin. The repressive structure must be removed to activate the endogenous stem cell transcription factor genes. The efficiency by which the endogenous genes are activated is poorly understood. Dozens of different proteins assist the four transcription factors during the reprogramming process. However, little is known of how the dozens of proteins coordinate their actions to remove the silent chromatin structures and replace them with active chromatin. Our goal is to study this process and use the resulting knowledge to improve the efficiency of iPS cell formation. This process can be studied by recreating it in a test tube or in vitro. This biochemical recreation involves three steps: 1. Generating highly pure versions of the four transcription factors. 2. Reproducing the silent chromatin environment of the gene. 3. And finally, identifying each of the steps involved in reactivating the endogenous genes. We have developed a technology that permits us to biochemically recreate silent chromatin on the transcription factor genes in vitro. We then attach the silent chromatin to magnetic beads, add protein mixtures from disrupted stem cells, and use magnets to capture beads with the attached proteins, which are in the process of converting silent chromatin to active chromatin. This "immobilized template capture" technique also allows us to delineate the steps involved in the reprogramming process. The proteins are identified by a state-of-the-art method known as multidimensional protein identification technology (MuDPIT). By combining the immobilized template and MuDPIT techniques, we will be able to provide detailed knowledge about how autoregulation is achieved. As such, we will be able to determine which specific steps are limiting in the conversion of fibroblast to iPS cells. Knowledge of the mechanism of stem cell gene regulation is essential for fully understanding stem cell self-renewal and the transition of fibroblasts to iPS cells. The information can be utilized to improve the efficiency of iPS cell formation.
Statement of Benefit to California:
California is investing 6 billion dollars in stem cell research with much of the principal being spent in the first 10-15 years on research and development. To date, much research has focused on the therapeutic potential of stem cells and understanding a few fundamental aspects of how stem cells self renew and differentiate. A major gap in our understanding lies in the most basic aspect of stem cell biology, the mechanics by which stem cell genes are regulated. To fully understand and to optimally manipulate the technology, a significant amount of basic knowledge must be obtained. The lack of basic mechanistic knowledge is what initially limited gene therapy and immunotherapy from achieving clinical application. For example, in gene therapy, we knew how to design therapeutic genes but knew little about how to deliver and regulate them. The situation has improved considerably in recent years, driven not by new technologies per se, but due to an investment in understanding basic mechanisms. We are now starting the same process with stem cells. Our technology and knowledge base have improved considerably but there are large gaps. Few scientists doubt the potential. However, many overestimate our knowledge base and ability to achieve therapeutic goals. It is important that we determine at the most basic level how stem cell genes are regulated. We know that four gene regulatory factors, when added to skin fibroblasts, can convert these into stem cells. However, we do not know precisely how they do this. To date, CIRM has invested heavily in labs trying to understand the functions of these four transcription factors in living cells. However, in the gene regulation field of biology, many of the major advances derived from biochemical or in vitro studies. My laboratory works on the fundamental aspects of how genes are regulated. We have recreated key events in a test tube. We have developed new biochemical approaches for determining how stem cell genes are regulated and for understanding how the four transcription factors function when bound to chromatin. Our studies will provide insight into and understanding of the processes by which stem cells self renew and differentiate. As such, the basic knowledge will help further the transition of into stem cells into clinical applications.
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Video hitting some serves - critique wanted
View Single Post
Join Date: Jul 2006
Location: tennis courts
Posts: 9,041
Originally Posted by
How would you know that unless you were on the receiving end of my serve?
Sure it looks not so great, but the result still is pretty good.
I get pretty good pace on my serve and can place it to body, wide or T.
Nobody is teeing off on my serve, I promise you. I play in Atlanta 3.5 & 4.0 singles and A8 level doubles. Atlanta has more tennis players per square mile than almost anywhere, so the competition level is very good.
Don't be fooled by a few practice serves on video....it's better than it "appears".
You are more than welcome to look me up next time in Atlanta and see how you
can "crush my serve"
. Where are you located anyway?
interesting. i was projecting obviously. so defensive haha. by the way i didnt say i would crush you. i said guys here like that would get crushed. i know atl has a huge tennis population. i am in the TWMAC we are the biggest chapter by far. if you ever come up lets hit.
better yet since you are calling yourself out lets see those serves down the T body and wide.
Member of TW MAC. yes, we are better than you. and we bout to hop on a court to make another 'mil
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'Harry Potter' over the years
Page 2 of 2
In November 2002, the 'Harry Potter and the Chamber of Secrets' film was released in Britain and the United States. And in 2003, 'Harry Potter and the Order of the Phoenix' was published. The fifth book in the series sold more than 5 million copies in its first day. With film openings brimming with Potter-caped kids and midnight-release parties planned at bookstores across the country, it was a Potter bonanza for fans, booksellers, and Warner Bros. alike.
In 2004, the film version of 'Harry Potter and the Prisoner of Azkaban' was released, making $92.7 million in the US. The three-day haul for the new film surpassed any previous 'Potter' film revenues. July 2007 was a heady month for Potterphiles: "Harry Potter and the Order of the Phoenix," the fifth movie in the series, was released in the same month as 'Harry Potter and the Deathly Hallows,' the seventh and final volume in the tale. It sold more than 11 million copies, snapped up during the first 24 hours of release.
The Wizarding World of Harry Potter theme park opened at Universal's Islands of Adventure park in Orlando, Florida, in June 2010. The 20-acre Harry Potter theme and dream park recreates the Hogwarts School of Witchcraft and Wizardry and reportedly cost $250 million to build. Later that year, in October, Rowling was interviewed by Oprah Winfrey, and admitted that she cried uncontrollably when she finished the last 'Potter' book. She also said she's not ruling out writing another one.
Since Harry Potter's introduction to the muggle world, Harry has become a global phenomenon. Over the past 15 years, we've read about his life in seven brick-thick books, watched him in seven films (soon to be eight). His books have sold more than 450 million copies worldwide and have been translated into 67 languages. His films so far have earned more than $6 billion at the global box office. But there's more to come.
The eighth and final installment of Warner Bros.' 'Harry Potter' movie franchise, 'Harry Potter and the Deathly Hallows: Part 2,' opens Friday, July 15. Warner Bros. reportedly paid $100 million for Leavesden Studios, where it filmed the movies. The numbers are incredible, reports the Hollywood Reporter: Actor Daniel Radcliffe wore out nearly 70 wands and 160 pairs of glasses during the making of the 'Harry Potter' films. Prop artists made 40 versions of Salazar Slytherin's locket to accommodate Ron and Harry's failed attempts to destroy it. Set artists used five 32-ton trucks' worth of polystyrene to create mounds of the rubble for 'Deathly Hallows.' And some 210,000 coins were made for the Gringotts bank scene. The number we're all waiting to see? Will "Deathly Hollows" trump all the previous 'Potter' films at the box office?
Husna Haq is a Monitor contributor.


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Solitary Man: movie review
Michael Douglas plays a self-destructive sleazy car salesman down on his luck in 'Solitary Man.'
Peter Kramer/AP/File
Michael Douglas is best known for playing unscrupulous corporate types, most iconically Gordon Gekko in "Wall Street," but he has also had a thriving minicareer playing dissolute types. Arguably his best performance is as the unraveled English professor in "Wonder Boys." So it was with no small expectation that I looked forward to "Solitary Man," where Douglas plays an amalgam of high-on-the-hog and down-on-his-luck. What could be a better combo for him?
As it turns out, the fit is a bit bulky. He's playing Ben, known on TV and on the cover of "Forbes" as "New York's honest car dealer." That was before he cheated his way out of his profession. Trying to crawl back into the business, he derails his chances by consistently chasing college-age women, or their mothers. Ben is even more successful as a self-sabotager than he was as a CEO. Is he deliberately trying to do himself in? Codirectors Brian Koppelman and David Levien, working from Koppelman's script, are vague about it. They're content to have us sit back and watch Ben disintegrate. No Dostoevskian depths here.


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Book now
Welcoming, functional... our Holiday apartment in Palermo is a perfect location for people looking for a Palermo Vacation Rental in our beautiful and sunny City of Art.
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1 bedroom, sleeps 4
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TV Languages in English, Local
Central heating
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Washing machine
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Pets (Please, inform us about.)
Sports and activities
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Last updated 25.02.2015
- From £213.03 per week
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- From £319.54 per week
- From £266.28 per week
- From £213.03 per week
- From £213.03 per week
- From £213.03 per week
Arrival date range | Minimum stay (nights) |
11th January 2015 to 31st December 2015 | 7 |
Discounts and extras
If more then one discount matches your arrival date, please be aware that only one discount of the highest amount will be applied to your booking.
Early Booking DiscountsArrival date range | Booking made more than x days/weeks/months before arrival | Discount |
1st January to 31st December | 3 Months | 5% |
Arrival date range | Booking made less then x days/weeks/months before arrival | Discount |
1st July to 31st August | 10 Days | 25% |
Arrival date range | Booking is equal to or longer than x days/weeks/months | Discount |
1st January to 31st December | 30 Days | 30% |
1st January to 31st December | 3 Weeks | 10% |
1st January to 31st December | 2 Weeks | 5% |
Compulsory extrasDescription | Arrival dates | Booking length or occupancy | Price |
Each person more | All year | Occupancy: more than 2 people |
£3.64 per additional person Paid with booking |
Description | Arrival dates | Booking length or occupancy | Price |
Full linen change (bed, bath, kitchen) | All year | on demand |
Paid locally |
Extra cleaning of the apartment | All year | on demand |
Paid locally |
Shuttle Service from Palermo Airport | All year | service per 2 people |
Paid locally |
Palermo TOUR - Visit of the most important touristic sites | All year | Tour |
Paid locally |
This is exact location
- Nearest beach: 10km
- Nearest bar: 1km
- Nearest restaurant: 2km
- Nearest supermarket: 1km
- Palermo Central railways station: 900m
- Palermo Sea Port: 1km
Rachael from Usk
Hi, my name is Pietro, I'm 47 years old living in Palermo, a sunny city of Art in the beatiful island of Sicily (Italy). My wife Simona and I have bought a little but charming and spacious loft that we rent to people looking for a welcoming apartment for holidays or business in any period of the year. We take pride to fournish tastefully our loft; it has hardwood floors both in the living area and bedroom loft above, ceiling vaulted with traditional log beams and wood decking, a well equipped and modern kitchen, with also a clothes washer, and comfortable furniture like the wardrobe closets and built in drawers just off the bath. We are responsive to any of our renters needs and we do our best to make pleasant their stay in our apartment. We are waiting for you!
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Picture before and after peniplasty penis lengthening and - Libido For Her Homeopathic Spray.
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Surgical Penis Enlargement Mini Forum ~ Penis surgery (Page 44 (http://www.thundersplace.org/penis-enlargement/surg ical-penis-enlargement-mini-forum-penis-surgery-44. html) In the week before, you should not take any medications containing aspirin Penoplasty can increase the size of the penis by increasing either length Photo was taken on February 8, 2007 and shows that after almost 12 January 19, 2014. A day in the life of a penis enlargement surgeon: London doctor (http://www.dailymail.co.uk/femail/article-2305385/A -day-life-penis-enlargement-surgeon-London-doctor-p erforms-penoplasties-week-demand-shoots-up.html) 8 Apr 2013 Penis extensions, or penoplasties, are becoming increasingly popular. So what's Where are the before and after photos?!! 4. 36. Click to rate.
January 12, 2014. The Twin Plastic Surgeons Making Headlines with Penoplasty (http://www.quickextenderpro.com/blog/twin-plastic-s urgeons-making-headlines-penoplasty/) 18 Oct 2013 Although born as identical twins, the Penoplasty from becoming the most sought after duo in the world of male enhancement surgery. Penis enlargement to increase length involves manipulating the suspensory ligament, Until then, penis enlargement options that don't require going under the knife December 28, 2013. TheChicGeek Investigates Penoplasty (http://www.thechicgeek.co.uk/features/news/grooming -news/2132-thechicgeek-investigates-penoplasty) 14 Aug 2013 before penis enlargement penoplasty Furthermore, the benefits of abdominal penis enlargement after penoplasty effect on clients psychologically, as this is really all about the man and his own self-image and esteem. Popular pages: |


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Vivian Dsena and Drashti Dhami
Vivian Dsena and Drashti Dhami
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Ultimate Software Customers Expand Knowledge, Network With Peers At 5th Annual Connections Conference
Ultimate Software (Nasdaq: ULTI), a leading cloud provider of people management solutions, announced today that more than 1,200 people attended the company's fifth annual customer and partner forum, held March 28-30 at the Bellagio Hotel in Las Vegas.
The 2012 Connections event brought together hundreds of HR, payroll, and talent management leaders to learn about industry best practices, technology trends, Ultimate Software's strategic roadmap, upcoming enhancements to UltiPro, and more. Each attendee had a unique opportunity to participate in hands-on lab sessions, network with other customers, interact with Ultimate's leadership, and meet industry analysts and influencers.
"The Connections Conference has been fantastic," said Pat Stram, SPHR, HR manager for Ripley's Entertainment, an entertainment leader for more than 90 years and known for the Ripley's Believe It or Not! brand of museums, cartoons, television shows, and books. "We really enjoyed expanding our knowledge about UltiPro and Ultimate Software while sharing information and meeting with our peers. I am very excited to get started using the information I have learned at Connections."
During the conference, Ultimate also announced a new partnership with Yammer, the leading provider of enterprise social networks. This collaboration seamlessly connects Yammer to Ultimate's HCM solution, enabling businesses to integrate the rich data about their people housed within UltiPro with the natural, continuous feedback on employees' work, achievements, progress, and cross-functional collaboration shared on Yammer.
"In addition to broadening its HR feature set, Ultimate's plan for the future includes social and mobile technologies, which indicates the company is on a clear path to sustaining its place in the market as the leader in people management cloud technology," said Stephanie Stevenson, AVP, compensation and benefits for Quicken Loans, Inc., the fifth largest retail mortgage lender overall in the U.S. and the largest online. Ultimate also presented its 2012 Customer Innovation Awards, which recognize customers that have gone above and beyond in managing, motivating, and rewarding their people. Each category singles out a customer that has excelled in a particular area of HCM through its partnership with Ultimate Software. The following organizations received a 2012 Innovation Award at the Connections conference:- Yamaha Corporation of America for Strategic Talent Management
- Groupon for Use of Analytics for Measurable Returns
- Callaway Golf for Achievement in Technology
- Buffalo Wild Wings for Teamwork
- Flow International for Global Impact
- Wente Family Estates for Supporting and Meeting Major Corporate Goals
- Camden Property Trust for Supporting and Meeting Major Corporate Goals
- United Stationers Inc. (USI) for Achievement in Return on Investment/Cost Savings
- Explorer Pipeline for Partnership
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Creating an account with Tribecafilm.com gives you access to more features and services, like our weekly newsletter and other special features just for the film community.
Creating an account with Tribecafilm.com gives you access to more features and services, like our weekly newsletter and other special features just for the film community.
It's almost a certainty that Isabella Rossellini and her valued collaborator Jody Shapiro did not embark on this project in response to a public opinion survey revealing widespread curiosity about the mating habits of insects. Indeed, this may be only the second time in history this topic has been considered worthy of artistic consideration-the first being by Cole Porter in "Let's Do It (Let's Fall In Love)," but while Porter was actually writing about falling in love, these films proclaim themselves to be pornography! I can attest to the fact that repeated viewings of all eight episodes of Green Porno have evoked no visible signs of arousal among any of us who have watched them repeatedly and avidly. What they have evoked are gales of laughter, and much intake of breath at the sheer audacity of making very small movies intended to be watched on very small screens. While eschewing Disneyesque cuteness for a style so direct it directs our gaze on occasion to several frankly yucky details about the reproductive habits of very small creatures, these films recall some of the wonder we felt, if perhaps only occasionally, in our earliest years in school. There are no microscopes or charts on display here though, only the delightfully faux-naif paper cutout costumes. Of course, the true capacity of these films to arouse will only be tested accurately when they are projected to audiences comprising viewers not customarily reached by cinema: bees, dragonflies, houseflies, mantises, snails, spiders, and worms. Since organizing screenings specifically for these creatures has proven difficult, we can't announce yet whether their reactions will evidence any more tumescence than was noted in our viewers belonging to the species homo sapiens, but we'll let you know. Meanwhile, all eight of these mini-epics play before each of our screenings of Guy Maddin's My Winnipeg, and additional screenings of them-in pairs, naturally-precede a select number of other features shown during the festival.
Isabella Rossellini has had a successful career as a model with over 500 magazine covers. As an actress, she has worked on numerous features, most notably Blue Velvet, Big Night, and Fearless. She has recently appeared on TV in Napoleon, Merlin, and 30 Rock. Her first foray behind the camera was as the writer and creator of My Dad Is 100 Years Old, directed by Guy Maddin. The film was included in a retrospective of her father, Roberto Rossellini's amazing body of work, which screened at MoMA and on an international cinematheque tour in various venues around the world. Green Porno is her directorial debut. Jody Shapiro has produced the work of acclaimed Canadian directors Atom Egoyan, David Cronenberg, and Guy Maddin. His latest film projects include Guy Maddin's My Winnipeg, which he produced and served on as director of photography. Jody is also producing and directing the documentary How to Start Your Own Country for The Documentary Channel in Canada. Jody is the co-chair for the Toronto-based Images Festival and a member of the Industry Advisory Committee for the Toronto International Film Festival.


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45. Will Dalligate mean a delayed Tobacco Products Directive? Don't Let it Happen!
on 24/10/12We may not be so silly that we give up before the goal! The real issue behind the whole #Dalligate story is not the future position of a single Commissioner or our shaked faith in President Barroso but the failure or success of the revision of the Tobacco Products Directive (2001/37/EC)
(Source of the photo © European Commission audivisual service)
This is the real and the only question we should really focus on.
If the revision happened as expected, we would handle satisfactorily this crisis by neglecting its personal dimension and keep focusing on the most important stake: the Tobacco Products Directive.
If the revision failed then the conspirators would win whoever stays behind the forced resign of John Dalli or the recent brake-in into 3 anti-tobbaco fighter NGOs' offices.
It is so simple. Either you get the point or the point gets you.
I am not saying that Dalli's (or Barroso's if it comes out later that the OLAF report and the whole procedure against Dalli was not well founded) personal fate is not a matter of importance. Of course it is.
They are very important persons shaping the EU's future being at the top of the mightiest institution of the EU.
However, they are single men in a very complicated institutional and political framework, and with all due respect, they are only politicians whose political mandate would reach an end in 2014 anyway.
On the other side, there is a crucial piece of EU legislation which has been already suffered 1 year delay by the way. The Tobacco Products Directive (2001/37/EC) concerns a wide range of population from a public health point of view. It will have a real long term effect on the population of 27 Member States determining indirectly the life-quality of several generations.
Being an EU blogger I know very well that it is always easier to follow persons and the drama gets much more media attention than the faceless and dry facts. However, behind these 'dry facts', behind the possible delay of the Tobacco Products Directive, there are also thousands and millions. Don't forget these people! Ordinary people desire also our attention not only the famous-ones.
"Most people give up just when they're about to achieve success. They quit on the one yard line." We simply shall be better than that!
As of today, both possibilities are still open. It is our responsibility if there will be a happy end at the end of that story.
I remain at your disposal.
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Related earlier EU Hemicycle updates:
30. Why can I strongly recommend the inauguration/maintenance of 'fat' or 'sin' taxes?
29. Gondolataim a hálapénz-rendszerről a magyar egészségügyben
23. Restructuring Health Systems: How to Promote Health in time of Austerity
Zoltán MASSAY-KOSUBEK
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► Follow @EU_Hemicycle on Twitter
► Join the ongoing EU Hemicycle discussions on LinkedIn


text: On Fri, Jan 02, 2004 at 11:55:00PM -0500, ashes wrote: > > I tested with gcc-3.3.1 before, now im trying a full build with > lfs-cvs. The patches are for gcc-3.3*. I'm pretty sure gcc2 will still > be able to build a kernel with propolice, but nothing else should be. > I think there are binary compat problems between ssp at GCC binaries and > ssp at Glibc systems, or vise vera. Keep in mind that we will be either building chapter6, or rebuilding chapter6. I'm not sure at this point which way we should go. One part of me says that rebuilding chapter 6 is a long process, the other part says that noobs should have completed LFS first before tackling this. Also if you fully follow the LFS book, then you have the more trivial conf files set up already and that keeps us from having to mention them unless there are security implications. -- Archaic It will be of little avail to the people, that the laws are made by men of their own choice, if the laws be so voluminous that they cannot be read, or so incoherent that they cannot be understood; if they be repealed or revised before they are promulgated, or undergo such incessant changes that no man, who knows what the law is to-day, can guess what it will be to-morrow. Law is defined to be a rule of action; but how can that be a rule, which is little known, and less fixed? - James Madison, Federalist Papers 62


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Behaviour management: Charlie Taylor's behaviour checklists
Ref: 5879
Last updated on 17 Mar 2014
Can you summarise the behaviour checklist produced by Charlie Taylor? We link to the DfE document in which the government's adviser on behaviour in schools gives a 'menu' of points from which schools can create their own behaviour checklist to use daily. We look at example lists from two schools.


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A CD of traditional and original folk music that tells the story of the famous murder ballad, Wild Bill Jones. Read more
A CD of traditional and original folk music that tells the story of the famous murder ballad, Wild Bill Jones.
About this project
The Quiet American Vol III: Wild Bill Jones is an album of traditional and original folk music that tells the story of one of America's most famous murder ballads, Wild Bill Jones. A classic love triangle that ends in tragedy, this album explores all sides of the story!
First recorded in 1924, the song Wild Bill Jones is about a young woman who goes out walking with a "bad man" Wild Bill Jones. Her lover confronts them and kills Wild Bill Jones in a violent rage. The Quiet American takes this ballad as a starting point for a folk opera/concept album/song cycle that includes original music as well as re-purposed traditional songs. This approach allows the listener to hear all sides of the tragic story and explore love, loss and redemption through the eyes of each character.
In order to get the best possible sounds for the record, Aaron has enlisted two of the NW's most experienced studios and engineers: Adam Selzer at Type Foundry Studies in Portland (M. Ward, The Decemberists) and Michael Connolly at Empty Sea studios in Seattle (Martha Scanlan, Coyote Grace). The goal is to create a one of a kind CD that pays homage to the folk tradition while engaging modern listeners as well.
Aaron's unique voice is accompanied by his guitar, ukulele, banjo and bass playing. His wife Nicole adds vocals, harmonium and percussion to the mix. Special guests include the Canote Brothers on fiddle and guitar.
This campaign is to help pay for recording, mixing and mastering. If we beat the goal, we will put the money towards pressing cds, graphic design and publicity. Thank you for all of your support, I hope you can be a part of the project!
Our original goal was to just pay for tracking. Now that we have passed that goal, we will be raising money for graphic design, photography, printing, duplication and publicity.
Pledge $10 or more
18 backers
An Mp3 download of the CD.
Estimated delivery: -
Pledge $20 or more
42 backers
Pre-order an autographed copy of the cd The Quiet American Vol III: Wild Bill Jones.
Estimated delivery: -
Pledge $35 or more
10 backers Limited (10 left of 20)
A one of a kind autographed Polaroid picture shot during the recording process. Also, the CD.
Estimated delivery: -
Pledge $45 or more
3 backers
Do you have a secret crush? A lifelong love? Email us the text of your love letter and Nicole will type it on our vintage typewriter, illustrate it and mail it to your sweet someone. The ultimate love note! Also, the CD.
Estimated delivery: -
Pledge $60 or more
4 backers
All of Aaron's previous song books:
Two Chord Songs,
Two Chord Songs Vol II,
Bourbon Cocktail Recipes and Drinking Songs,
Jug Band, Hokum and Pre-War Blues.Also, the new CD.
Estimated delivery: -
Pledge $100 or more
1 backer
Aaron will record a folk song for you. Pick your favorite public domain folk song and Aaron will record it and send you an mp3! Also, the new cd.
Estimated delivery: -
Pledge $250 or more
2 backers Limited (2 left of 4)
A skype music lesson. Aaron will teach a one hour lesson via skype. Aaron no longer teaches private lessons, so this is a rare treat! If you are in the NW, you can come up to Hood RIver for a lesson and a drink instead! Also, the new cd.
Estimated delivery: -
Pledge $750 or more
1 backer Limited (4 left of 5)
Aaron and Nicole will perform an exclusive house concert for you and your friends. Please contact Aaron about your location before you bid, this is for Oregon and Washington. Other locations will need to pitch in for travel.
Also, the new cd.Estimated delivery: -
Pledge $1,250 or more
0 backers Limited (5 left of 5)
House concert plus cocktail night! Did you know Aaron is also a talented mixologist? Besides performing a house concert for you and your friends, Aaron will also provide one of his signature cocktails! Oregon or Washington only. Also, the new CD.
Estimated delivery: -
Pledge $3,000 or more
1 backer All gone!
A Mya-Moe ukulele, specifications configured and hand built by Aaron. You pick soprano, concert or tenor and Aaron will pick the rest! Also, the new CD.
Estimated delivery:
Funding period
- (30 days)


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PetiteThis is Kyle or what used to be him. Kyle had a brother named Logan who always hated how Kyle did everything better than he did, sports, school, even girls. He was sick of it so one day surfing the web Logan found a spell that was supposed to get rid of someone so he memorized it. The next day Logan was waiting for Kyle at home. When Kyle walked in Logan hit him with a baseball bat. While Kyle was unconscious he used the spell only he forgot some words & instead of Kyle disappearing. Instead of being his 22 year old self he became a 20 year old he shrunk from 6 foot 6 to a petite 5 foot 1, his brown buzz cut turned blonde & grew down past his shoulders, his features became less masculine he lost all his muscle, his arms, legs, hands, & feet grew small & slender, his clothes changed from a leather jacket & jeans to a tight fitting corset & matching panties, his waist become more curved, & his hips cracked outward, his changes were finally wrapping up when two giant DD formed in his ches
Wedding TGIt was a beautiful sunny Saturday afternoon, not a cloud in the sky.It was the day of my sister's wedding. She had been planning it for months now, everything had to be perfect.Everyone was seated in the church. The vicar was ready for the service. The groom was standing, ready for his future wife to walk down the isle.I was sat at the front, waiting to see my sister walk down to see her in her wedding dress for the first time.Suddenly, Chrissie, one of the bridesmaids tapped me on the shoulder."Ric, you're sister beeds to see you, now"Wihtout even being allowed to respond, I was rushed outside into a small room where I saw my sister stood on the far side."Rach, you look so...""Quiet Ric. Now listen, I need to ask you something very important.""What?""One of the bridesmaids hasn't shown up""And this concerns me how?""Well, I need you to replace her.""What do you mean. I know you, everything has to be perfect. All the bridesmaid have to be exactly right, so how can you stan


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The labels on my Chinook and Columbus hops have worn away and I do not remember which is which. Is there any way to figure out by aroma or sight? One definitely has a more "piney" aroma. Or should I just assign one plant to he Chinook and the other to be Columbus and move forward? I really hate that I did this... Thanks!
I've got both...and they're both about ready to harvest. I'll see if I can get some pics for you. My CTZ is Zeus, but from what I understand it's the same as Columbus.
I could murder a pint! -Lovejoy
Here you go...hope this comes out ok. Of the 5 varieties I have, these two look the most alike. It looks like the chinook leaves are a bit more "wasp-waisted" than the zeus. The cones look very similar.
My chinook and goldings plants didn't do real well this year as you can see by the cone. My cascade, centennial and zeus just went crazy....tons of cones! Anyway, as for aroma, I do get a much sharper pine aroma from the chinook. I'm not the best when it comes to discerning subtle nuances in aroma and flavor, but I can definitely tell the difference in aroma between these two.
Are those young cones a real accurate representation of hop varietals? Chinook should be elongated, and the CTZ should be tighter.
The chinook cones in my pictures are probably not a perfect example. I really didn't have any "full-size" chinook cones. This was the first year for all of my plants. The Zeus, Cascade, Centennial and Nugget (to a lesser extent) all produced much bigger cones. Even the Zeus in the picture is probably not as big as most of them...probably in the middle somewhere.
Thanks Beowulf this is exactly what I needed to see! Problem solved...finally. From now on Ill be using a label maker instead of Sharpie...
Good to hear that you figured it out ... but since I already took the picture, here are some of the different size cones on my Chinook.