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The prize, awarded by MIT's McGovern Institute, honors outstanding achievements in neuroscience. It recognizes Gilbert's work on visual perception and brain plasticity. More »
February 4, 2015
"In the past century of neuroscience, there's been a lot of analysis of individual neurons and synapses, and, more recently, imaging of the whole brain. But we scientists think everything of substance happens in between these two scales. It's as if you're studying New York City with a microscope and satellite images. But what you really want is to look at it on a human scale." -Cori Bargmann
January 31, 2015
January 28, 2015
"[Opiate addiction] 'alters multiple regions in the brain,' [Mary Jeanne] Kreek said, 'including those that regulate reward, memory and learning, stress responsivity, and hormonal response, as well as executive function which is involved in decision-making — simply put, when to say yes and when to say no.'"
January 20, 2015
December 23, 2014
December 22, 2014
"'We do know from my own work on depression that there seems to be several different parts of the brain involved [in creativity]. Different parts of the brain are all speaking to each other. We're trying to figure out how they're speaking to each other.'
[Dr. Greengard] continued: 'I'm sure our brains are working unconsciously. When you have a creative thought, it's parts of the brain talking to each other without your awareness.'"
November 13, 2014
" 'It was a really good evolutionary move,' said Leslie Vosshall of Rockefeller University in New York, who led the study published in the journal Nature, 'We provide the ideal lifestyle for mosquitoes. We always have water around for them to breed in, we are hairless and we live in large groups.' "
November 9, 2014
"[Dr.] Allis is considered the father of one of the hottest fields in 21st century science. Called epigenetics, it is the study of a phenomenon that 20th century biology said shouldn't exist – changes in molecules that are outside the DNA but can nevertheless be passed from cell to cell or even from one generation to the next."
October 27, 2014
"We don't 'pillory people for being very tall or short,' [Jeffrey] Friedman said, so it makes no sense to blame obese people for being that way–or for obese people to feel ashamed."
October 23, 2014
"Bruce McEwen, a neuroscientist who studies stress at Rockefeller University in New York, said the fear can lead people to change their lifestyle, making them isolate themselves, lose sleep, stop exercising, change their diet for the worse and drink or smoke."
October 16, 2014
"Torsten Wiesel is president emeritus of Rockefeller University in New York City. He shared half of the 1981 Nobel Prize in Physiology or Medicine with David Hubel for their discoveries concerning information processing in the visual system. He tells Stefano Sandrone about his greatest scientific achievement and his vision of the future."
October 9, 2014
"'It really has to do with the reckless and the brave,' says Bruce McEwen at Rockefeller University, New York, who wasn't involved with the work. The brave feel fear but are able to overcome it, whereas the reckless seem to have a brain that doesn't react as it should to alert them to danger, he says."
September 15, 2014
"A 'stop heart attack' refrain echoes through Rockefeller University's 'molecular biomedicine music video' featuring some flashy animation and seriously geeky dancing."
August 5, 2014
"As the threat of climate change has evolved from a fuzzy faraway concept to one of the central existential threats to humanity, scholars like Professor [Joel E.] Cohen have noted that reducing the burning of fossil fuels might be easier if there were fewer of us consuming them."
July 28, 2014
"A lot of the legal and commercial groundwork has been established between Accelerator and its partner institutions, which should help speed the business-development process, said Marc Tessier-Lavigne, president of Rockefeller University."
July 27, 2014
"Dr. Marler was one of the first ethologists to produce graphic snapshots of birdsong — streaks of ink on paper, like an electrocardiogram, showing the wave-frequency, modulation and pitch of various calls and songs.
From that data, Dr. Marler and his colleagues discovered that some species had repertoires of only a few songs while others had as many as 100. They found they could analyze and differentiate calls within the same species — calls for roosting, seeking food, mating, territory-marking, warning of danger and summoning help, known as mobbing, to ward off an intruder."
July 16, 2014
"Stress raises our heart rate and ramps our immune systems to prepare for injury and danger. 'The problem is if we don't turn those responses off efficiently when the danger is over … they can cause damage,' [Bruce] McEwen says."
July 11, 2014
Scientists from the Laboratory of Stem Cell Biology and Molecular Embryology at Rockefeller University are using principles from geometry to control the patterns through which [human embryonic stem cells] develop.
July 9, 2014
July 9, 2014
"'But science has yet to gain Veronica Mars status,' notes Jeanne Garbarino, director of science outreach at Rockefeller University in New York, who has used crowdfunding and informally advised others. Instead, scientific projects tend to be far more modest, generally raising just thousands or tens of thousands of dollars."
June 5, 2014
"The report, from a committee led by Cori Bargmann of Rockefeller University and William Newsome of Stanford University, emphasizes technology development for the first five years, and use of the new technology in scientific inquiry in the second five years."
May 27, 2014
"President Barack Obama lauded whiz kids at the White House Science Fair on Tuesday, including Elana Simon [daughter of Sanford Simon], an 18-year-old who helped research a rare liver cancer that she was diagnosed with at age 12."
May 16, 2014
"Ultimately, the neuroscience experts concluded, for all the research and progress that's been done about the brain and its many powers, there's still a far way to go. 'It's like the space program except it's inner-space instead of outer space,' [Cori] Bargmann said of existing research programs, including her own. "There are more connections between those nerve cells than there are stars in the Milky Way. I think there's an incredible untapped potential in understanding the way the brain works."
April 28, 2014
"Food, [Jesse Ausubel] told me, is a little like clothing. 'There are large companies that turn out the blue jeans and T-shirts we all wear. We don't mind large scale for that. But sometimes we all want a little something nicer, a little more fashionable. Even people without much money want something of their own or something they made themselves. Character matters, so does a sense of ownership. It's the same story with food.'"
March 26, 2014
"Where can you find dozens of parents in a room with Nobel prize-winning scientists? At The Rockefeller University's one-of-a-kind Parents and Science initiative. Launched in 2007, the initiative helps parents learn more about research in childhood health and behavior by meeting face-to-face with Rockefeller scientists."
March 20, 2014
"As [Leslie] Vosshall put it: 'The world is always changing. Plants are evolving new smells. Perfume companies are making new scents. You might move to some part of the world where you've never encountered the fruits and vegetables and flowers that grow there. But your nose is ready. With a sensory system that is that complex, we are fully ready for anything."
March 14, 2014
"Dr. Cori Bargmann of Rockefeller University studies how biology, our genes and the environment we live in can affect the way we act. She is especially interested in understanding social behaviors. Believe it or not, she studies worms to examine the underlying biology that can switch an individual from being a loner to a party animal, and vice versa."
March 4, 2014
"Two studies [one by David Ho, director of the Aaron Diamond AIDS Research Center at Rockefeller University] each found 100 percent protection in monkeys that got monthly injections of antiretroviral drugs, and there was evidence that a single shot every three months might work just as well. If the findings can be replicated in humans, they have the potential to overcome a major problem in AIDS prevention: that many people fail to take their antiretroviral pills regularly."
February 27, 2014
"Making that idea work required a lot of help from real scientists: Her father, [Sanford Simon], who runs a cellular biophysics lab at The Rockefeller University; her surgeon at Memorial Sloan-Kettering Cancer Center; and gene specialists at the New York Genome Center. Together, the team reported Thursday that they uncovered an oddity: A break in genetic material that left the 'head' of one gene fused to the 'body' of another. That results in an abnormal protein that forms inside the tumors but not in normal liver tissue, suggesting it might fuel cancer growth."
January 28, 2014
"Our major challenge, hopefully one taken up by the next generation of young scientists who are intrigued with epigenetics, will be to learn how to better harness the potential of the epigenetic mechanisms to bring about better health and living for many," Dr. Allis said. "I look forward to that in the years ahead, and I am pleased that some of our work has contributed to this worthwhile goal."
January 22, 2014
"While everyone's eager for cures and discoveries, RU's scientists openly share that generous donor-funding encourages them to be productive and take risks, but thankfully relieves them of the fear of losing funding—which research scientists elsewhere often face. Neurobiologist Dr. Leslie Vosshall says, 'This is one of the few places on earth where you're given a cloistered environment to test crazy ideas and with plenty of support you don't have to worry about bringing in grant money.'"
December 6, 2013
"Pediatric neurologist and neuroscientist Huda Y. Zoghbi won Rockefeller University's 10th annual Pearl Meister Greengard Prize, which on Thursday night she attributed in part to following 'a gut feeling.' For 16 years, she tracked down a gene mutation that causes Rett Syndrome, a form of autism that only affects girls. None of her male colleagues supported her hunch that Rett Syndrome could be a genetic disorder."
December 1, 2013
"That study of Earth's human population is only a drop in the bucket of the diverse, seemingly disparate, subjects that Cohen has addressed in his five-decade-long career. His studies of food webs, asbestos-related litigation, and infectious disease have resulted in more than 390 papers and 14 books, and all these pursuits are underwritten by Cohen's passionate belief that mathematics contains the most powerful tools for considering the problems of life."
November 1, 2013
"[The] first event, The Future Of The Brain, has a great lineup. You'll hear from Cori Bargmann, the Breathrough Prize-winning neurobiologist from Rockefeller University, whose work with roundworms has shed new light on how neural circuits are formed and function."
September 30, 2013
"Over the past year, Mark Stoeckle and his team from Rockefeller University did some pretty dirty work, collecting hundreds of dead cockroaches for the National Cockroach Project, a study aimed at analyzing the usually unwelcome creatures."
September 4, 2013
"For a lot of the way that different brain regions work together to generate complex functions, we're really stumbling around in the dark," said Dr. Cori Bargmann, a Rockefeller University neuroscientist and co-chair of the project. "The point of the brain initiative is to turn on some lights."
August 2, 2013
"Biology graduate student Tom McDonagh, of Rockefeller University, likes working with light. For his Ph.D. he built a spinning microscope that uses centrifugal force to test the gripping power of different molecules. McDonagh also innovates with light outside the lab, in tech-savvy shadow puppet plays."
July 3, 2013
"I was amazed to watch two paraplegics walk independently using the ReWalk robotic device and moved when they showed how leaving their wheelchairs has transformed their lives," said Rockefeller University President Marc Tessier-Lavigne, also the head of its Laboratory of Brain Development and Repair.
June 30, 2013
"[Leslie Vosshall's] dedication to her work seems jaw-droppingly insane, especially at feeding times."
June 3, 2013
"To create the mutant mosquitoes, Dr. Vosshall and her colleagues altered an odor receptor, orco. Not only did the resulting mosquitoes struggle to tell the difference between humans and other animals, but they were unable to detect the presence of DEET, the insect repellent, before it was too late."
May 31, 2013
"I think the problems of life are the most fascinating problems, and I love the clarity of mathematical tools…. I think of humans as embedded in a network of relationships with the species we eat, the species that eat us and the species we share the planet with. And this is helpful for understanding things as important to us as our own health and our survival and our well-being."
May 6, 2013
"[Dr. de Duve] discovered the lysosome, a tiny sack filled with enzymes that functions like a garbage disposal, destroying bacteria or parts of the cell that are old or worn out. His discoveries helped unravel the biology of Tay-Sachs disease and more than two dozen other genetic diseases in which a shortage of lysosomal enzymes causes waste to accumulate in cells and eventually destroy them."
April 12, 2013
"Bacteriophages, viruses that infect bacterial cells, employ an arsenal of chemical weapons. Microbiologist Vincent Fischetti of Rockefeller University describes using tricks learned from the phage in developing new antibiotics that may be effective even where others fail."
April 2, 2013
"A working group at the N.I.H., described by the officials as a 'dream team,' and led by Cori Bargmann of Rockefeller University and William Newsome of Stanford University, will be charged with coming up with a plan, a time frame, specific goals and cost estimates for future budgets."
April 1, 2013
"Erec Stebbins is an award-winning researcher at Rockefeller University. In his spare time, he has written an absorbing thriller about an FBI agent tracking down home grown terrorists. The book is called The Ragnarök Conspiracy."
March 6, 2013
"In short, even prior to the 5 percent budget cut brought about last week by sequestration, our basic research enterprise has been in crisis. This erosion in our basic science investment has occurred at the very time that the biomedical revolution has opened huge opportunities to advance our knowledge of disease."
February 23, 2013
"Dr. Cori Bargmann of Rockefeller University received an unexpected phone call…she was told that she had been chosen to receive a $3 million cash prize for her research in brain development, which will hopefully provide breakthroughs in disorders like autism and schizophrenia."
February 20, 2013
"Be physically active, get a good diet, [get] adequate sleep, [create] social support, have a good hobby, meditate. All of these things really are common sense and now we know they do have the benefits of improving our brain architecture."
January 26, 2013
"Elsewhere, research by one of us, Bruce McEwen, has closed in on how pre- and postnatal stress affects a complex set of interactions between the hypothalamus, the pituitary gland and the adrenal glands (the HPA axis). These are all part of the body's neuroendocrine system, which controls our reactions to stress and regulates many things, including digestion, the immune system, emotions, sexuality and the storage and expenditure of energy."
January 22, 2013
"High school students supervised by New York's Rockefeller University found alarming results in testing done over the last three years. Sixteen percent of the grocery store food they DNA tested, from expensive sheep's milk cheese that had only cow DNA in it, to caviar that wasn't made of sturgeon eggs, to pet food with no meat, all had counterfeit ingredients."
January 20, 2013
"We were all brought up to think the genome was it," said Rockefeller University molecular biologist C. David Allis. "It's really been a watershed in understanding that there is something beyond the genome."
January 3, 2013
"A consortium of scientists [including The Rockefeller University] announced that they had devised a way to enable simultaneous editing of several sites within the mammalian genome. The technology, based on a bacterial defense system against viruses, could offer an easy-to-use, less-expensive way to engineer organisms that produce biofuels, to design animal models to study human disease, and to develop new therapies, among other potential applications."
December 21, 2012
"In the long struggle that was to come, [Ralph] Steinman would try anything and everything that might extend his life, but he placed his greatest hope in a field he helped create, one based on discoveries for which he would earn his Nobel Prize. He hoped to reprogram his immune cells to defeat his cancer — to concoct a set of treatments from his body's own ingredients, which could take over from his chemotherapy and form a customized, dynamic treatment for his disease."
December 20, 2012
"Humanity has reached what Rockefeller University scientists, in a new report, call 'peak farmland.' In the next half-century, a geographical area more than twice the size of France — or equivalent to 10 Iowas — will return to its natural state from farmland, they predict."
December 20, 2012
"[O]ceans have actually become very loud due to man-made noise from oil rigs, sonar and ship propellers. And scientists are worried that all that added noise is hurting marine life. So they're planning a massive experiment to quiet the ocean and study what kind of impact that quieting has. It's called the 'International Quiet Ocean Experiment'. WBUR All Things Considered host Sacha Pfeiffer spoke about this project with Jesse Ausubel, director of the Program for the Human Environment at Rockefeller University in New York and an adjunct faculty member at the Woods Hole Oceanographic Institution."
October 15, 2012
"The research re-energizes a century-old treatment method that was abandoned with the rise of antibiotics during World War II. As germs have built up a resistance to those drugs in recent years, scientists are seeking alternatives and the virus strategy "is in vogue again," said Vincent Fischetti, a biologist at Rockefeller University in New York who is one of the pioneers of the revived approach."
September 12, 2012
"The exercise in this experiment was quite mild," [Bruce S. McEwen] says — the equivalent of jogging at a pace at which someone could speak (or squeak) to a companion. "That's achievable for most people," he concludes, "and the evidence suggests that it will improve brain health."
September 12, 2012
"Is there a less polarized way to think about the future of farming? Jesse H. Ausubel, an environmental scientist who directs the Program for the Human Environment at Rockefeller University, thinks he's found one… His claim is that high-yield farming, that is, high-tech, non-organic agricultural practices that produce more crops per square foot, is actually kinder to the environment than lower-tech, organic farming."
September 3, 2012
"More broadly, [Paul Nurse] doesn't fret about American dominance. That is just the way it is. Perhaps some cultural differences even accrue to the British side of the ledger. 'The U.S.A. has a very strong work ethic, and you keep a very close eye to the cutting edge,' he says. 'We are a bit lazier. We drink more. But sometimes the science we produce is rather quirkier and more innovative.'"
August 7, 2012
"These days electricity is so important to industrial society that providing adequate power isn't good enough. For example, businesses that rely on the Internet simply can't afford to be without power, even for a minute. Sure, it was a nuisance for Indian commuters on electric trains to get stranded. But, [Jesse] Ausubel says, the risk to our interconnected world runs much deeper. 'It's not just the railroads stopping, it really is the signal that if you want to be in the 21st century economy, you need to be very, very good at electricity,' he says."
August 6, 2012
"On the other hand, ask [Jesse Ausubel] about climate change (a subject he helped make the hot topic it is today), or overpopulation, or deforestation and you'll get a surprisingly reassuring answer: things are getting better, we're on the right track. It's an attitude based on his extensive analyses of past trends in energy production, population growth, consumer behavior, and a host of other factors."
July 20, 2012
"The first trials for patient safety are expected to start this year. It is a moment that Vincent Fischetti, a 71-year-old microbiologist at the Rockefeller University, has been approaching for decades. A child of working-class parents on Long Island, he once thought he would be a dentist before getting hooked on microbiology as an undergraduate."
July 9, 2012
"We asked Dr. Jules Hirsch, emeritus professor and emeritus physician in chief at Rockefeller University, who has been researching obesity for nearly 60 years, about the state of the research. Dr. Hirsch…wrote some of the classic papers describing why it is so hard to lose weight and why it usually comes back."
July 1, 2012
"We had no winter in the Northeast this year, and so there's a lot of predictions from mosquito control experts that we're going to have a really huge season of high populations of mosquitoes, and so with that, more disease transmission," said Leslie Vosshall, who runs Rockefeller University's Laboratory of Neurogenetics and Behavior in New York City. Along with her staff, she's trying to find out exactly how mosquitoes hunt humans.
June 20, 2012
"That leads demographer Joel Cohen to predict that 'many of us may live to see population peak in the middle of this century.' If so, that would fulfill the first necessary condition to begin to reduce our demands on the planet."
"An analysis by Jesse Ausubel and Paul Waggoner of Rockefeller University in New York City suggests that this trend of more economic bang per resource buck is widespread among developing economies, following an initial 'cheap and dirty' phase of growth."
May 20, 2012
"'They're hunters,' says Leslie Vosshall, the Robin Chemers Neustein Professor at the Rockefeller University of New York, an expert on the science of smell and someone who is not afraid to put her arm into a chamber of mosquitoes and get bitten a lot. 'And they've adapted to be very sensitive to the smell of their prey, be it birds or humans.'"
May 14, 2012
"Nature is a great architect, and the vascular network – or veins – of a leaf are key to its structure. Mathematical physicists [Marcelo Magnasco and Eleni Katifori] at Rockefeller University use fluorescent dye and time lapse photography to digitally study microscopic patterns within these vascular networks in order to better understand how nutrients flow through the leaf and into the plant's cells."
May 3, 2012
"The work, in which a team used radio waves to switch on engineered insulin-producing genes in mice, is published today in Science. Jeffrey Friedman, a molecular geneticist at the Rockefeller University in New York and lead author of the study, says that in the short term, the results will lead to better tools to allow scientists to manipulate cells non-invasively. But with refinement, he thinks, clinical applications could also be possible."
April 19, 2012
"A pair of Rockefeller University scientists will forever be honored with a new professorship, designed to pay tribute to the spirit of collaboration and mentoring. It was 1970 when Ralph M. Steinman came to Rockefeller University to be a postdoc in the lab of Zanvil A. Cohn. It was in those first few years of research on how an immune response is triggered in the human body, that the men came to identify a novel cell type. They coined the term dendritic cells."
March 28, 2012
"Dr. James E. Darnell Jr. and Robert G. Roeder, Ph.D., both of whom work at Rockefeller University in New York City, will receive the [Albany Medical Center] prize during a May 11 ceremony in Albany. The $500,000 prize is the largest award in medicine and science in the United States. Darnell and Roeder, working separately over more than five decades, discovered how cells work and control protein production — activities that are the foundation for every process in the body."
March 23, 2012
"A former student and teacher duo at the Massachusetts Institute of Technology will receive $250,000 from the March of Dimes next month for creating advances in treating skin cancers, severe burns and other skin diseases…[Elaine] Fuchs began working in Green's lab in 1977 and throughout their careers they have shared their scientific findings, many of which have translated into specific treatments toward pioneering new technologies that explain the molecular underpinnings of skin stem cells and inherited skin disorders."
February 7, 2012
"Norton D. Zinder, a researcher who helped lay the basis for the new field of molecular biology in the 1950s and '60s and who played a crucial role in the politics of decoding the human genome, died on Friday in a nursing home in the Riverdale section of the Bronx. He was 83."
December 19, 2011
"But the rule against posthumous awards has now been violated several times — most recently this month, when the prize in medicine was given to the widow of Dr. Ralph M. Steinman, a scientist at Rockefeller University in Manhattan who died of pancreatic cancer at age 68 on Sept. 30, three days before his election."
November 30, 2011
Yale Environment 360
The New Story of Stuff: Can We Consume Less?
"Optimists such as Jesse Ausubel, director of the Program for the Human Environment at The Rockefeller University in New York, see a long-term and unstoppable trend that is the logical outcome of what economists call the environmental Kuznets curve, after its inventor Simon Kuznets. This suggests that as countries industrialize, they pass through an early "cheap and dirty" phase when they waste resources and generate massive pollution, but they pass a tipping point beyond which they begin to invest in using resources more efficiently."
November 14, 2011
"Sir Paul Nurse, 62, has the effusive and infectious enthusiasm of a natural leader who, it is obvious, leads by example rather than threat. By his own admission, he has an idealistic view of science 'as a liberalising and progressive force for humanity.' He sees science as a truly international activity that breaks down barriers between the peoples of the world. Science, he says, is a 'profoundly aesthetic experience which gives pleasure not unlike the reading of a great poem.'"
November 8, 2011
93-Year-Old Wins Prestigious Science Award
"At 93-years-old, Brenda Milner is responsible for some of the biggest discoveries in the science of memory. And she's still working today, at McGill University in Montreal, Canada. She's also the winner of the prestigious Pearl Meister Greengard Prize for her achievements, which includes $100,000 in award money."
November 6, 2011
'Nosy' and Observant, a Neuroscientist Continues Her Memorable Career at 93
"Psychology students who read about Brenda Milner's seminal work with amnesia patients nearly 60 years ago might not suspect that she is, at 93, still engaged full time in research and teaching. Nor that last week, in New York, she would be picking up a major award, the Pearl Meister Greengard Prize, which honors female researchers who have made extraordinary contributions to the biomedical sciences. She is the eighth recipient of the prize since its creation by Paul Greengard, a neuroscientist at Rockefeller University, who used his own funds, including his award for winning the Nobel Prize in Physiology or Medicine, along with contributions from his university and other donors."
October 31, 2011
Among large economies, the United States is second only to Australia in the amount of carbon dioxide it emits per capita, according to the latest figures from the federal Energy Information Administration. "Every person you add to the country makes all these tremendous demands on the environment," said Joel E. Cohen, chief of the Laboratory of Populations at Rockefeller University and Columbia University. But experts are reluctant to suggest an ideal birth rate. "There isn't any magic number," Dr. Cohen said.
October 26, 2011
"But it is also possible, said Dr. Jules Hirsch of Rockefeller University, that researchers just do not know enough about obesity to prescribe solutions. One thing is clear, he said: 'A vast effort to persuade the public to change its habits just hasn't prevented or cured obesity.' 'We need more knowledge,' Dr. Hirsch said. 'Condemning the public for their uncontrollable hedonism and the food industry for its inequities just doesn't seem to be turning the tide.'"
September 19, 2011
"Across town at the Rockefeller University, the new science facility, by Mitchell/Giurgola Architects, exists for no other purpose than to bring people out of isolation. It's an addendum, a voluptuous glass link, seven stories high, interposed between two preexisting laboratory buildings. You enter what appears to be a modest lobby, and ahead of you the space opens up, Guggenheim-like, into an atrium whose floorplan is elliptical and whose side elevation is shaped like an hourglass. Everything about this unusual building tells you that scientific research can be conducted in an environment of both zest and dignity."
September 16, 2011
"'Over 2,700 marine scientists in over 80 nations made the first-ever census of marine life over the past decade," said Jesse Ausubel, director of the Program for the Human Environment at Rockefeller University, speaking recently at a packed Secret Science Club program at the Bell House near the Gowanus Canal."
August 30, 2011
"Peter Holt, a researcher at Rockefeller University in New York, said that overweight patients who have the common 'stomach stapling' operations are likely to have large concentrations of alcohol in the blood even if they drink little, which take a long time to wear off. As a result, Dr. Holt suggested that all patients who undergo weight-loss surgery should be warned about the effects on their ability to drink and should think about avoiding alcohol completely if they drive."
August 21, 2011
"Dr. Greengard, 85, is still making breakthroughs. In an offshoot of his award-winning research, the director of the Fisher Center for Alzheimer's Research recently discovered a new pathway for potentially treating the disease. He identified a protein in mice that stimulates the production of beta amyloid, a substance that forms plaque in the brain and disrupts memory and other cognitive functions. And in an interesting development, he found that a cancer drug, Gleevec, disarms the protein."
August 15, 2011
"Consider the investigation of Mike Rossner, executive director of the Rockefeller University Press. In 2002, while trying to format a scientific image in Photoshop that was going to appear in one of the journals, Rossner noticed that the background of the image contained different intensities of pixels. This led Rossner and his colleagues to begin analyzing every image in every accepted paper."
August 13, 2011
"'The problems are here and now,' said Joel Cohen, head of the laboratory of populations at New York's Rockefeller University. 'People forget there are a billion chronically hungry people; every day those people wake up and they're hungry all day, and they go to sleep hungry.'"
August 5, 2011
After the success of protease inhibitors in HIV, research groups around the world began investigating whether the same mechanism would work for hepatitis C. In 1997 Charles M. Rice, now head of the laboratory of virology and infectious disease at the Rockefeller University, showed that mutating the viral protease in hepatitis C–infected chimpanzees stopped the virus, the first clue about the enzyme's importance.
June 7, 2011
Joel E. Cohen: "[René Dubos] wrote near the end of this essay: 'For some human beings, perhaps for most, living implies the kind of Life envisaged by Spinoza — with the effort that caps nature with culture, existence with meaning, and facts with forms.' Dubos was one of the lucky humans whose efforts capped nature with culture, existence with meaning, and facts with forms."
June 6, 2011
"With the Great Reversal, the study's authors believe a tipping point has been reached, with countries now able to pursue policies to boost their forests' thickness and carbon capacities dramatically. Jesse Ausubel, a director at the Rockefeller University and a co-author, said: 'The enlarging forests in almost 50 nations studied may signal the start of a welcome and necessary restoration.'"
May 5, 2011
Joel E. Cohen: "Of today's (almost) 7 billion people, nearly one billion are chronically hungry. Why? Roughly one third of grain is consumed by domestic animals. More than one sixth of grain goes into industrial products like biofuels and starch, seeds and other uses. Less than half of world cereal production feeds humans. The world chooses to feed its machines and its domestic animals before it feeds its people."
April 27, 2011
"'To tell different wines apart, a good memory is required,' says Leslie Vosshall, a professor at Rockefeller University. 'It would be like going to a museum where someone shows you 10 paintings and then you have to express some preference about them. It would help if you could say, well in the first painting, I really liked the way the skirts were painted, and in the second, the facial expressions were really good.'"
April 26, 2011
"Researchers found that painkillers such as aspirin and ibuprofen appear to decrease the effectiveness of a popular class of antidepressants that includes Prozac and Celexa. The finding, published Monday, may help explain why even the most effective antidepressants don't work for everyone. At best only about two-thirds of patients respond effectively to Celexa and other selective serotonin reuptake inhibitors, or SSRIs. 'Physicians should consider the advantages and disadvantages of giving an anti-inflammatory with the antidepressant depending on how severe the pain is and how depressed they are,' said Paul Greengard, senior author on the paper."
April 26, 2011
"'Dinochelus ausubeli' was the name conferred earlier this year on a strange deep sea monster, a lobster discovered off the Philippine coast whose right claw is elongated into a fearsome pincer. The new species was named not after its discoverer, but in honor of the person under whose auspices a fleet of 540 ships from 80 nations has found the lobster and 6,000 other new marine species in the last 10 years. He is Jesse H. Ausubel, a Rockefeller University environmental researcher who is also vice president of the Alfred P. Sloan Foundation of New York."
March 6, 2011
"One hundred thousand of the world's most valuable rodents live on York Avenue as residents of Rockefeller University, whose relative obscurity among the city's higher-learning establishments belies its elite status in the medical community. (Twenty-three Nobel laureates have done work at the school, which doesn't offer undergrad degrees.) A few of its more cooperative mice — and one rat — recently took turns in front of our cameras."
March 4, 2011
"If you were writing a play, the sequence of the genome is like having the list of characters at the beginning of the play. You can't write the play without the list of characters, that's essential, but actually there's a lot of work that has to go on that depends on that human genome sequence but which isn't simply a consequence of it. It's a prerequisite but it's not the end of the story."
February 22, 2011
"So what's not right about food? Based on an analysis of Earth's resources, our planet should be able to sustain 11 billion people on a vegetarian diet, said Joel Cohen, a population expert at the Rockefeller University. But among the current population of 7 billion, 'a billion of those are hungry' already, he said. One of the reasons he sees is that humans are sharing their agricultural grains with livestock as well as machines (in the form of feedstock for biofuel conversion). 'We're using less than half of the cereal we grow to feed humans,' Cohen said."
February 21, 2011
"'It took until about 1800 or 1825 to put the first billion people on the planet. We added the most recent billion in 12 or 13 years. We anticipate two billion more by 2050.' That's Joel Cohen, head of the Laboratory of Populations at Rockefeller University in New York. 'In the last half century, people have estimated human-carrying capacities for the Earth that have ranged from less than one billion to more than a trillion. They can't all be right. In fact, those numbers are political numbers, not scientific numbers. Because the question how many people can the earth support is an incomplete question, and doesn't take account of with what technologies, at what average level of well-being, with what distribution of income, with what political and economic institutions.'"
July 21, 2014
Nature Immunology online: July 21, 2014
Type I and type II Fc receptors regulate innate and adaptive immunity
Andrew Pincetic, Stylianos Bournazos, David J DiLillo, Jad Maamary, Taia T. Wang, Rony Dahan, Benjamin-Maximillian Fiebiger and Jeffrey V. Ravetch
July 17, 2014
Cell 158, 300–313
Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility
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July 13, 2014
Nature Cell Biology online July 13, 2014
Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN
Scott E. Williams, Lyndsay A. Ratliff, Maria Pia Postiglione, Juergen A. Knoblich and Elaine Fuchs
July 9, 2014
Nature online: July 9, 2014
Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins | Newswire
Hani Goodarzi, Steven Zhang, Colin G. Buss, Lisa Fish, Saeed Tavazoie and Sohail F. Tavazoie
July 2, 2014
Neuron 83(1):178-88
Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington's Disease
Joshua L. Plotkin, Michelle Day, Jamys D. Peterson, Zhong Xie, Geraldine J. Kress, Igor Rafalovich, Jyothisri Kondapalli, Tracy S. Gertler, Marc Flajolet, Paul Greengard, Mihaela Stavarache, Michael G. Kaplitt, Jim Rosinski, C. Savio Chan and D. James Surmeier
June 22, 2014
Nature Cell Biology online: June 22, 2014
The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment
Mu He, Radhika Subramanian, Fiona Bangs, Tatiana Omelchenko, Karel F. Liem Jr, Tarun M. Kapoor & Kathryn V. Anderson
June 20, 2014
Science 344, 1401-1405 | Newswire
HIV-1–induced AIDS in monkeys
Theodora Hatziioannou,Gregory Q. Del Prete, Brandon F. Keele, Jacob D. Estes, Matthew W. McNatt, Julia Bitzegeio, Alice Raymond, Anthony Rodriguez, Fabian Schmidt, C. Mac Trubey, Jeremy Smedley, Michael Piatak Jr., Vineet N. KewalRamani, Jeffrey D. Lifson and Paul D. Bieniasz
June 17, 2014
Journal of Clinical Investigation online: June 15, 2014
Netrin-1 controls sympathetic arterial innervation
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June 15, 2014
Nature Chemical Biology online: June 15, 2014
DrugTargetSeqR: a genomics- and CRISPR-Cas9-based method to analyze drug targets
Corynn Kasap, Olivier Elemento and Tarun M. Kapoor
May 29, 2014
Science online: May 29, 2014
Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism
Kai Xu, Zhuhao Wu, Nicolas Renier, Alexander Antipenko, Dorothea Tzvetkova-Robev, Yan Xu, Maria Minchenko, Vincenzo Nardi-Dei, Kanagalaghatta R. Rajashankar, Juha Himanen, Marc Tessier-Lavigne and Dimitar B. Nikolov
May 29, 2014
Nature 509: 637–640
Clonal selection in the germinal centre by regulated proliferation and hypermutation
Alexander D. Gitlin, Ziv Shulman and Michel C. Nussenzweig
May 22, 2014
Cell 157: 1230-1242
Molecular profiling of neurons based on connectivity
Mats I. Ekstrand, Alexander R. Nectow, Zachary A. Knight, Kaamashri N. Latcha, Lisa E. Pomeranz and Jeffrey M. Friedman
May 20, 2014
Proceedings of the National Academy of Sciences USA 111: 7325-7330
Histone variant H3.3 is an essential maternal factor for oocyte reprogramming
Duancheng Wen, Laura A. Banaszynski, Ying Liu, Fuqiang Geng, Kyung-Min Noh, Jenny Xiang, Olivier Elemento, Zev Rosenwaks, C. David Allis and Shahin Rafii
May 12, 2014
Journal of Experimental Medicine online: May 12, 2014
A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice
Hyung Jin Ahn, J. Fraser Glickman, Ka Lai Poon, Daria Zamolodchikov, Odella C. Jno-Charles, Erin H. Norris and Sidney Strickland
May 12, 2014
Journal of Experimental Medicine 211(6):1049-62
A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice
Hyung Jin Ahn, J. Fraser Glickman, Ka Lai Poon, Daria Zamolodchikov, Odella C. Jno-Charles, Erin H. Norris and Sidney Strickland
May 8, 2014
Cell 157: 935-949
Transit-amplifying cells orchestrate stem cell activity and tissue regeneration
Ya-Chieh Hsu, Lishi Li and Elaine Fuchs
May 7, 2014
Neuron 82: 682-694
Incremental integration of global contours through interplay between visual cortical areas
Minggui Chen, Yin Yan, Xiajing Gong, Charles D. Gilbert, Hualou Liang and Wu Li
April 28, 2014
Proceedings of the National Academy of Sciences USA online: April 28, 2014
Structure of the branched intermediate in protein splicing
Zhihua Liu, Silvia Frutos, Matthew J. Bick, Miquel Vila-Perelló, Galia T. Debelouchina, Seth A. Darst and Tom W. Muir
April 24, 2014
Cell 157: 636-650
Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function
Ender Karaca, Stefan Weitzer, Davut Pehlivan, Hiroshi Shiraishi, Tasos Gogakos, Toshikatsu Hanada, Shalini N. Jhangiani, Wojciech Wiszniewski, Marjorie Withers, Ian M. Campbell, Serkan Erdin, Sedat Isikay, Luis M. Franco, Claudia Gonzaga-Jauregui, Tomasz Gambin, Violet Gelowani, Jill V. Hunter, Gozde Yesil, Erkan Koparir, Sarenur Yilmaz, Miguel Brown, Daniel Briskin, Markus Hafner, Pavel Morozov, Thalia A. Farazi, Christian Bernreuther, Markus Glatzel, Siegfried Trattnig, Joachim Friske, Claudia Kronnerwetter, Matthew N. Bainbridge, Alper Gezdirici, Mehmet Seven, Donna M. Muzny, Eric Boerwinkle, Mustafa Ozen, Tim Clausen, Thomas Tuschl, Adnan Yuksel, Andreas Hess, Richard A. Gibbs, Javier Martinez, Josef M. Penninger and James R. Lupski
April 24, 2014
Proceedings of the National Academy of Sciences USA online: April 24, 2014
A model for the generation and transmission of variations in evolution
Olivier Rivoire and Stanislas Leibler
April 10, 2014
Cell 157: 420-432
Asymmetric friction of nonmotor MAPs can lead to their directional motion in active microtubule networks
Scott Forth, Kuo-Chiang Hsia, Yuta Shimamoto and Tarun M. Kapoor
April 8, 2014
Proceedings of the National Academy of Sciences USA 111: 1393-1401
Dynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line
Aaron B. Steiner, Taeryn Kim, Victoria Cabot and A. J. Hudspeth
April 6, 2014
Nature Genetics online: April 6, 2014
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
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March 30, 2014
Nature Chemical Biology online: March 30, 2014
Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark
Lunzhi Dai, Chao Peng, Emilie Montellier, Zhike Lu, Yue Chen, Haruhiko Ishii, Alexandra Debernardi, Thierry Buchou, Sophie Rousseaux, Fulai Jin, Benjamin R. Sabari, Zhiyou Deng, C. David Allis, Bing Ren, Saadi Khochbin and Yingming Zhao
March 21, 2014
Science 343: 1370-1372
Humans can discriminate more than 1 trillion olfactory stimuli
C. Bushdid, M. O. Magnasco, L. B. Vosshall and A. Keller
March 11, 2014
Molecular Psychiatry online: March 11, 2014
Preliminary evidence that early reduction in p11 levels in natural killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram
P. Svenningsson, L. Berg, D. Matthews, D. F. Ionescu, E. M. Richards, M. J. Niciu, A. Malinger, M. Toups, H. Manji, M. H. Trivedi, C. A. Zarate Jr. and P. Greengard
March 7, 2014
Science 343: 1151-1154
Long-acting integrase inhibitor protects macaques from intrarectal simian/human immunodeficiency virus
Chasity D. Andrews, William R. Spreen, Hiroshi Mohri, Lee Moss, Susan Ford, Agegnehu Gettie, Kasi Russell-Lodrigue, Rudolf P. Bohm, Cecilia Cheng-Mayer, Zhi Hong, Martin Markowitz and David D. Ho
March 5, 2014
Proceedings of the National Academy of Sciences USA online: March 5, 2014
Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia
Myriam Heiman, Adrian Heilbut,Veronica Francardo, Ruth Kulicke, Robert J. Fenster, Eric D. Kolaczyk, Jill P. Mesirov, Dalton J. Surmeier, M. Angela Cenci and Paul Greengard
March 4, 2014
Proceedings of the National Academy of Sciences USA 111: 3614-3619
Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels
Stephen G. Brohawn, Zhenwei Su and Roderick MacKinnon
March 3, 2014
Proceedings of the National Academy of Sciences USA online: March 3, 2014
microRNAs are biomarkers of oncogenic human papillomavirus infections
Xiaohong Wang, Hsu-Kun Wang, Yang Li, Markus Hafner, Nilam Sanjib Banerjee, Shuang Tang, Daniel Briskin, Craig Meyers, Louise T. Chow, Xing Xie, Thomas Tuschl and Zhi-Ming Zheng
March 3, 2014
Current Biology 24: 494-508
FLRT3 is a robo1-interacting protein that determines netrin-1 attraction in developing axons
Eduardo Leyva-Díaz, Daniel del Toro, Maria José Menal, Serafi Cambray, Rafael Susín, Marc Tessier-Lavigne, Rüdiger Klein, Joaquim Egea and Guillermina López-Bendito
February 28, 2014
Science 343: 1010-1014
Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma
Joshua N. Honeyman, Elana P. Simon, Nicolas Robine, Rachel Chiaroni-Clarke, David G. Darcy, Irene Isabel P. Lim, Caroline E. Gleason, Jennifer M. Murphy, Brad R. Rosenberg, Lydia Teegan, Constantin N. Takacs, Sergio Botero, Rachel Belote, Soren Germer, Anne-Katrin Emde, Vladimir Vacic, Umesh Bhanot, Michael P. LaQuaglia and Sanford M. Simon
February 27, 2014
Cell 156: 1060-1071
Multimodal integration of carbon dioxide and other sensory cues drives mosquito attraction to humans
Conor J. McMeniman, Román A. Corfas, Benjamin J. Matthews, Scott A. Ritchie and Leslie B. Vosshall
February 27, 2014
Cell 156: 986-1001
Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation
Nora Pencheva, Colin G. Buss, Jessica Posada, Taha Merghoub and Sohail F. Tavazoie
February 20, 2014
Molecular Cell 53: 655-662
Replication origin selection regulates the distribution of meiotic recombination
Pei-Yun Jenny Wu and Paul Nurse
February 18, 2014
Proceedings of the National Academy of Sciences USA online: February 18, 2014
Chemical-biogeographic survey of secondary metabolism in soil
Zachary Charlop-Powers, Jeremy G. Owen, Boojala Vijay B. Reddy, Melinda A. Ternei and Sean F. Brady
February 18, 2014
Proceedings of the National Academy of Sciences USA 111: 2770-2775
Inducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channels
Navin Pokala, Qiang Liu, Andrew Gordus and Cornelia I. Bargmann
February 17, 2014
Current Biology 24: 451-458
The genome of the clonal raider ant Cerapachys biroi
Peter R. Oxley, Lu Ji, Ingrid Fetter-Pruneda, Sean K. McKenzie, Cai Li, Haofu Hu, Guojie Zhang and Daniel J.C. Kronauer
February 15, 2014
Genes and Development 28: 328-341
SOX9: a stem cell transcriptional regulator of secreted niche signaling factors
Meelis Kadaja, Brice E. Keyes, Mingyan Lin, H. Amalia Pasolli, Maria Genander, Lisa Polak, Nicole Stokes, Deyou Zheng and Elaine Fuchs
February 12, 2014
Cell Host Microbe 15: 190-202
Interferon lambda alleles predict innate antiviral immune responses and hepatitis C virus permissiveness
Timothy Sheahan, Naoko Imanaka, Svetlana Marukian, Marcus Dorner, Peng Liu, Alexander Ploss and Charles M. Rice
February 12, 2014
Proceedings of the National Academy of Sciences USA online: February 12, 2014
Structure of a myosin adaptor complex and pairing by cargo
Hang Shi, Nimisha Singh, Filipp Esselborn and Günter Blobel
February 9, 2014
Nature online: February 9, 2014
L-Myc expression by dendritic cells is required for optimal T-cell priming
Wumesh KC, Ansuman T. Satpathy, Aaron S. Rapaport, Carlos G. Briseño, Xiaodi Wu, Jörn C. Albring, Emilie V. Russler-Germain, Nicole M. Kretzer, Vivek Durai, Stephen P. Persaud, Brian T. Edelson, Jakob Loschko, Marina Cella, Paul M. Allen, Michel C. Nussenzweig, Marco Colonna, Barry P. Sleckman, Theresa L. Murphy and Kenneth M. Murphy
February 5, 2014
Neuron 81: 616-628
Temporal responses of C. elegans chemosensory neurons are preserved in behavioral dynamics
Saul Kato, Yifan Xu, Christine E. Cho, L.F. Abbott and Cornelia I. Bargmann
February 4, 2014
Proceedings of the National Academy of Sciences USA 111: E537-545
Hydrodynamics and collective behavior of the tethered bacterium Thiovulum majus
Alexander Petroff and Albert Libchaber
February 3, 2014
Journal of Clinical Investigation 124: 725-729
Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity
Stylianos Bournazos, Siu-Kei Chow, Nareen Abboud, Arturo Casadevall and Jeffrey V. Ravetch
January 30, 2014
Cell 156: 522-536
Control of stress-induced persistent anxiety by an extra-amygdala septohypothalamic circuit
Todd E. Anthony, Nick Dee, Amy Bernard, Walter Lerchner, Nathaniel Heintz and David J. Anderson
January 26, 2014
Nature Cell Biology online: January 26, 2014
In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators
Wen-Hui Lien, Lisa Polak, Mingyan Lin, Kenneth Lay, Deyou Zheng and Elaine Fuchs
January 17, 2014
Science online: January 17, 2014
Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas
Daniel Schramek, Ataman Sendoel, Jeremy P. Segal, Slobodan Beronja, Evan Heller, Daniel Oristian, Boris Reva and Elaine Fuchs
January 12, 2014
Nature Medicine online: January 12, 2014
Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo
David J. DiLillo, Gene S. Tan, Peter Palese and Jeffrey V. Ravetch
December 22, 2013
Nature Medicine online: December 22, 2013
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection
Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K. Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T. Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P. Coelho, Stefan H. Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M. Rice, Katherine A. Fitzgerald, Winfried Barchet and Maria M. Mota
December 17, 2013
Molecular Psychiatry online: December 17, 2013
Hippocampal gene expression changes underlying stress sensitization and recovery
J.D. Gray, T.G. Rubin, R.G. Hunter and B.S. McEwen
December 17, 2013
Proceedings of the National Academy of Sciences USA 110: 20455-20460
Flavin reduction activates Drosophila cryptochrome
Anand T. Vaidya, Deniz Top, Craig C. Manahan, Joshua M. Tokuda, Sheng Zhang, Lois Pollack, Michael W. Young and Brian R. Crane
December 12, 2013
Molecular Cell 52: 734-45
Autoinhibition and polo-dependent multisite phosphorylation restrict activity of the histone H3 kinase haspin to mitosis
Cristina Ghenoiu, Michael S. Wheelock and Hironori Funabiki
December 6, 2013
Science 342: 1254-1258
MicroRNA-128 governs neuronal excitability and motor behavior in mice
Chan Lek Tan, Joshua L. Plotkin, Morten T. Venø, Melanie von Schimmelmann, Philip Feinberg, Silas Mann, Annie Handler, Jørgen Kjems, D. James Surmeier, Dónal O'Carroll, Paul Greengard and Anne Schaefer
November 27, 2013
Genes and Development online: November 27, 2013
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation
Junwei Shi, Warren A. Whyte, Cinthya J. Zepeda-Mendoza, Joseph P. Milazzo, Chen Shen, Jae-Seok Roe, Jessica L. Minder, Fatih Mercan, Eric Wang, Melanie A. Eckersley-Maslin, Amy E. Campbell, Shinpei Kawaoka, Sarah Shareef, Zhu Zhu, Jude Kendall, Matthias Muhar, Christian Haslinger, Ming Yu, Robert G. Roeder, Michael A. Wigler, Gerd A. Blobel, Johannes Zuber, David L. Spector, Richard A. Young and Christopher R. Vakoc
November 27, 2013
Nature online: November 27, 2013
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
John W. Schoggins, Donna A. MacDuff, Naoko Imanaka, Maria D. Gainey, Bimmi Shrestha, Jennifer L. Eitson, Katrina B. Mar, R. Blake Richardson, Alexander V. Ratushny, Vladimir Litvak, Rea Dabelic, Balaji Manicassamy, John D. Aitchison, Alan Aderem, Richard M. Elliott, Adolfo García-Sastre, Vincent Racaniello, Eric J. Snijder, Wayne M. Yokoyama, Michael S. Diamond, Herbert W. Virgin and Charles M. Rice
November 26, 2013
Proceedings of the National Academy of Sciences USA online: November 26, 2013
Nfatc1 orchestrates aging in hair follicle stem cells
Brice E. Keyes, Jeremy P. Segal, Evan Heller, Wen-Hui Lien, Chiung-Ying Chang, Xingyi Guo, Dan S. Oristian, Deyou Zheng and Elaine Fuchs
November 26, 2013
Proceedings of the National Academy of Sciences USA 110: 19501-19506
Antitumor activities of agonistic anti-TNFR antibodies require differential FcγRIIB coengagement in vivo
Fubin Li and Jeffrey V. Ravetch
November 25, 2013
Journal of Experimental Medicine online: November 25, 2013
Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission
Marine Malbec, Françoise Porrot, Rejane Rua, Joshua Horwitz, Florian Klein, Ari Halper-Stromberg, Johannes F. Scheid, Caroline Eden, Hugo Mouquet, Michel C. Nussenzweig and
Olivier Schwartz
November 24, 2013
Nature Structural Molecular Biology online: November 24, 2013
The human cap-binding complex is functionally connected to the nuclear RNA exosome
Peter Refsing Andersen, Michal Domanski, Maiken S. Kristiansen, Helena Storvall, Evgenia Ntini, Celine Verheggen, Aleks Schein, Jakob Bunkenborg, Ina Poser, Marie Hallais, Rickard Sandberg, Anthony Hyman, John LaCava, Michael P. Rout, Jens S. Andersen, Edouard Bertrand and Torben Heick Jensen
November 24, 2013
Nature Neuroscience online: November 24, 2013
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
Jessica J. Walsh, Allyson K. Friedman, Haosheng Sun, Elizabeth A. Heller, Stacy M. Ku, Barbara Juarez, Veronica L. Burnham, Michelle S. Mazei-Robison, Deveroux Ferguson, Sam A. Golden, Ja Wook Koo, Dipesh Chaudhury, Daniel J. Christoffel, Lisa Pomeranz, Jeffrey M. Friedman, Scott J. Russo, Eric J. Nestler and Ming-Hu Han
November 21, 2013
Cell 155: 1034-1048
Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition
Martin S. Taylor, John LaCava, Paolo Mita, Kelly R. Molloy, Cheng Ran Lisa Huang, Donghui Li, Emily M. Adney, Hua Jiang, Kathleen H. Burns, Brian T. Chait, Michael P. Rout, Jef D. Boekesend and Lixin Daisend
November 18, 2013
Journal of Experimental Medicine 210: 2739-2753
Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells
Elissa K. Deenick, Danielle T. Avery, Anna Chan, Lucinda J. Berglund, Megan L. Ives, Leen Moens, Jennifer L. Stoddard, Jacinta Bustamante, Stephanie Boisson-Dupuis, Miyuki Tsumura, Masao Kobayashi, Peter D. Arkwright, Diana Averbuch, Dan Engelhard, Joachim Roesler, Jane Peake, Melanie Wong, Stephen Adelstein, Sharon Choo, Joanne M. Smart, Martyn A. French, David A. Fulcher, Matthew C. Cook, Capucine Picard, Anne Durandy, Christoph Klein, Steven M. Holland, Gulbu Uzel, Jean-Laurent Casanova, Cindy S. Ma and Stuart G. Tangye
November 11, 2013
Proceedings of the National Academy of Sciences USA online: November 11, 2013
Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of σ70 domain 1.1
Brian Bae, Elizabeth Davis, Daniel Brown, Elizabeth A. Campbell, Sivaramesh Wigneshweraraj and Seth A. Darst
November 7, 2013
Cell 155: 881-893
Opposing dopaminergic and GABAergic neurons control the duration and persistence of copulation in Drosophila
Michael A. Crickmore and Leslie B. Vosshall
November 6, 2013
Neuron online: November 6, 2013
Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin
Jing Yang, Robby M. Weimer, Dara Kallop, Olav Olsen, Zhuhao Wu, Nicolas Renier, Kunihiro Uryu and Marc Tessier-Lavigne
October 30, 2013
Nature online: October 30, 2013
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
Dan H. Barouch, James B. Whitney, Brian Moldt, Florian Klein, Thiago Y. Oliveira, Jinyan Liu, Kathryn E. Stephenson, Hui-Wen Chang, Karthik Shekhar, Sanjana Gupta, Joseph P. Nkolola, Michael S. Seaman, Kaitlin M. Smith, Erica N. Borducchi, Crystal Cabral, Jeffrey Y. Smith, Stephen Blackmore, Srisowmya Sanisetty, James R. Perry, Matthew Beck, Mark G. Lewis, William Rinaldi, Arup K. Chakraborty, Pascal Poignard, Michel C. Nussenzweig and Dennis R. Burton
October 30, 2013
Nature online: October 30, 2013
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia
Masashi Shingai, Yoshiaki Nishimura, Florian Klein, Hugo Mouquet, Olivia K. Donau, Ronald Plishka, Alicia Buckler-White, Michael Seaman, Michael Piatak, Jeffrey D. Lifson, Dimiter Dimitrov, Michel C. Nussenzweig and Malcolm A. Martin
October 24, 2013
Nature 502: 563-566
MX2 is an interferon-induced inhibitor of HIV-1 infection
Melissa Kane, Shalini S. Yadav, Julia Bitzegeio, Sebla B. Kutluay, Trinity Zang, Sam J. Wilson, John W. Schoggins, Charles M. Rice, Masahiro Yamashita, Theodora Hatziioannou and Paul D. Bieniasz
October 22, 2013
Proceedings of the National Academy of Sciences USA 110: 4108-4117
Network model of top-down influences on local gain and contextual interactions in visual cortex
Valentin Piëch, Wu Li, George N. Reeke and Charles D. Gilbert
October 21, 2013
Proceedings of the National Academy of Sciences USA online: October 21, 2013
High-throughput imaging of neuronal activity in Caenorhabditis elegans
Johannes Larsch, Donovan Ventimiglia, Cornelia I. Bargmann and Dirk R. Albrecht
October 17, 2013
Immunity 39: 676-686
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis
Bertrand Boissonsend, Chenhui Wang, Vincent Pedergnana, Ling Wu, Sophie Cypowyj, Michel Rybojad, Aziz Belkadi, Capucine Picard, Laurent Abel, Claire Fieschi, Anne Puel, Xiaoxia Li and Jean-Laurent Casanova
October 16, 2013
New England Journal of Medicine 369: 1704-1714
Deep dermatophytosis and inherited CARD9 deficiency
Fanny Lanternier, Saad Pathan, Quentin B. Vincent, Luyan Liu, Sophie Cypowyj, Carolina Prando, Mélanie Migaud, Lynda Taibi, Aomar Ammar-Khodja, Omar Boudghene Stambouli, Boumediene Guellil, Frederique Jacobs, Jean-Christophe Goffard, Kinda Schepers, Véronique del Marmol, Lobna Boussofara, Mohamed Denguezli, Molka Larif, Hervé Bachelez, Laurence Michel, Gérard Lefranc, Rod Hay, Gregory Jouvion, Fabrice Chretien, Sylvie Fraitag, Marie-Elisabeth Bougnoux, Merad Boudia, Laurent Abel, Olivier Lortholary, Jean-Laurent Casanova, Capucine Picard, Bodo Grimbacher and Anne Puel
October 10, 2013
Cell 155: 345-356
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent t-loop formation
Ylli Doksani, John Y. Wu, Titia de Lange and Xiaowei Zhuang
October 6, 2013
Nature Biotechnology online: October 6, 2013
Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1-neutralizing activity
Ruijiang Song, Deena A. Oren, David Franco, Michael S. Seaman and David D. Ho
September 26, 2013
Cell 155: 107-120
Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells
Laura A. Banaszynski, Duancheng Wen, Scott Dewell, Sarah J. Whitcomb, Mingyan Lin, Nichole Diaz, Simon J. Elsässer, Ariane Chapgier, Aaron D. Goldberg, Eli Canaani, Shahin Rafii, Deyou Zheng and C. David Allis
September 25, 2013
Developmental Cell online: September 25, 2013
Chromatin-bound Xenopus Dppa2 shapes the nucleus by locally inhibiting microtubule assembly
John Z. Xue, Eileen M. Woo, Lisa Postow, Brian T. Chait and Hironori Funabiki
September 25, 2013
Proceedings of the National Academy of Sciences USA online: September 25, 2013
Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy
Yuan Tian, Jerry C. Chang, Emily Y. Fan, Marc Flajolet and Paul Greengard
September 23, 2013
The EMBO Journal online: September 24, 2013
IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage
HyeonJoo Cheon, Elise G. Holvey-Bates, John W. Schoggins, Samuel Forster, Paul Hertzog, Naoko Imanaka, Charles M. Rice, Mark W. Jackson, Damian J. Junk and George R. Stark
September 23, 2013
Proceedings of the National Academy of Sciences USA online: September 23, 2013
Structure and nucleic acid binding activity of the nucleoporin Nup157
Hyuk-Soo Seo, Bartlomiej J. Blus, Nina Z. Janković and Günter Blobel
September 16, 2013
Proceedings of the National Academy of Sciences USA online: September 16, 2013
HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice
Joshua A. Horwitz, Ariel Halper-Stromberg, Hugo Mouquet, Alexander D. Gitlin, Anna Tretiakova, Thomas R. Eisenreich, Marine Malbec, Sophia Gravemann, Eva Billerbeck, Marcus Dorner, Hildegard Büning, Olivier Schwartz, Elena Knops, Rolf Kaiser, Michael S. Seaman, James M. Wilson, Charles M. Rice, Alexander Ploss, Pamela J. Bjorkman, Florian Klein and Michel C. Nussenzweig
September 16, 2013
Journal of Experimental Medicine online: September 16, 2013
Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium
Heidi A. Schreiber, Jakob Loschko, Roos A. Karssemeijer, Amelia Escolano, Matthew M. Meredith, Daniel Mucida, Pierre Guermonprez and Michel C. Nussenzweig
September 9, 2013
Proceedings of the National Academy of Sciences USA online: September 9, 2013
Decisions on the fly in cellular sensory systems
Eric D. Siggia and Massimo Vergassola
September 5, 2013
Cell Stem Cell 13: 314-327
Architectural niche organization by LHX2 is linked to hair follicle stem cell function
Alicia R. Folgueras, Xingyi Guo, H. Amalia Pasolli, Nicole Stokes, Lisa Polak, Deyou Zheng and Elaine Fuchs
September 1, 2013
Nature Structural and Molecular Biology online: September 1, 2013
Regulation of transcription by the MLL2 complex and MLL complex–associated AKAP95
Hao Jiang, Xiangdong Lu, Miho Shimada, Yali Dou, Zhanyun Tang and Robert G. Roeder
August 26, 2013
Proceedings of the National Academy of Sciences USA online: August 26, 2013
Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)
Michael J. Fuller, Benoit Callendret, Baogong Zhu, Gordon J. Freeman, Dana L. Hasselschwert, William Satterfield, Arlene H. Sharpe, Lynn B. Dustin, Charles M. Rice, Arash Grakoui, Rafi Ahmed and Christopher M. Walker
August 26, 2013
Proceedings of the National Academy of Sciences USA online: August 26, 2013
H3R42me2a is a histone modification with positive transcriptional effects
Fabio Casadio, Xiangdong Lu, Samuel B. Pollock, Gary LeRoy, Benjamin A. Garcia, Tom W. Muir, Robert G. Roeder and C. David Allis
August 26, 2013
Journal of Experimental Medicine 210: 1,871-1,888
Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract
Darren Ruane, Lucas Brane, Bernardo Sgarbi Reis, Cheolho Cheong, Jordan Poles, Yoonkyung Do, Hongfa Zhu, Klara Velinzon, Jae-Hoon Choi, Natalie Studt, Lloyd Mayer, Ed C. Lavelle, Ralph M. Steinman, Daniel Mucida and Saurabh Mehandru
August 22, 2013
Immunity 39: 245-258
Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies
Tongqing Zhou, Jiang Zhu, Xueling Wu, Stephanie Moquin, Baoshan Zhang, Priyamvada Acharya, Ivelin S. Georgiev, Han R. Altae-Tran, Gwo-Yu Chuang, M. Gordon Joyce, Young Do Kwon, Nancy S. Longo, Mark K. Louder, Timothy Luongo, Krisha McKee, Chaim A. Schramm, Jeff Skinner, Yongping Yang, Zhongjia Yang, Zhenhai Zhang, Anqi Zheng, Mattia Bonsignori, Barton F. Haynes, Johannes F. Scheid, Michel C. Nussenzweig, Melissa Simek, Dennis R. Burton, Wayne C. Koff, NISC Comparative Sequencing Program, James C. Mullikin, Mark Connors, Lawrence Shapiro, Gary J. Nabel, John R. Mascolasend and Peter D. Kwongsend
August 20, 2013
Cell online: August 20, 2013
Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans
Steven W. Flavell, Navin Pokala, Evan Z. Macosko, Dirk R. Albrecht, Johannes Larsch and Cornelia I. Bargmann
August 15, 2013
Cell 154: 748-762
Structure-function analysis of STING activation by c[G(2′,5′)pA(3′,5′)p] and targeting by antiviral DMXAA
Pu Gao, Manuel Ascano, Thomas Zillinger, Weiyi Wang, Peihong Dai, Artem A. Serganov, Barbara L. Gaffney, Stewart Shuman, Roger A. Jones, Liang Deng, Gunther Hartmann, Winfried Barchet, Thomas Tuschl and Dinshaw J. Patel
August 14, 2013
Nature online: August 14, 2013
RNAi screens in mice identify physiological regulators of oncogenic growth
Slobodan Beronja, Peter Janki, Evan Heller, Wen-Hui Lien, Brice E. Keyes, Naoki Oshimori and Elaine Fuchs
August 8, 2013
Proceedings of the National Academy of Sciences USA online: August 8, 2013
UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling
Carlene Moore, Ferda Cevikbas, H. Amalia Pasolli, Yong Chen, Wei Kong, Cordula Kempkes, Puja Parekh, Suk Hee Lee, Nelly-Ange Kontchou, Iwei Ye, Nan Marie Jokerst, Elaine Fuchs, Martin Steinhoff and Wolfgang B. Liedtke
August 4, 2013
Nature Immunology online: August 4, 2013
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens
Ansuman T. Satpathy, Carlos G. Briseño, Jacob S. Lee, Dennis Ng, Nicholas A. Manieri, Wumesh K.C., Xiaodi Wu, Stephanie R. Thomas, Wan-Ling Lee, Mustafa Turkoz, Keely G. McDonald, Matthew M. Meredith, Christina Song, Cynthia J. Guidos, Rodney D. Newberry, Wenjun Ouyang, Theresa L. Murphy, Thaddeus S. Stappenbeck, Jennifer L. Gommerman, Michel C. Nussenzweig, Marco Colonna, Raphael Kopan and Kenneth M. Murphy
July 31, 2013
Nature online: July 31, 2013
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
Marcus Dorner, Joshua A. Horwitz, Bridget M. Donovan, Rachael N. Labitt, William C. Budell, Tamar Friling, Alexander Vogt, Maria Teresa Catanese, Takashi Satoh, Taro Kawai, Shizuo Akira, Mansun Law, Charles M. Rice and Alexander Ploss
July 29, 2013
Proceedings of the National Academy of Sciences USA online: July 29, 2013
Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling
Fredrik Wermeling, Robert M. Anthony, Frank Brombacher and Jeffrey V. Ravetch
July 29, 2013
Proceedings of the National Academy of Sciences USA online: July 29, 2013
Behavioral diversity in microbes and low-dimensional phenotypic spaces
David Jordan, Seppe Kuehn, Eleni Katifori and Stanislas Leibler
July 29, 2013
Journal of Experimental Medicine online: July 29, 2013
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
Tyler R. Simpson, Fubin Li, Welby Montalvo-Ortiz, Manuel A. Sepulveda, Katharina Bergerhoff, Frederick Arce, Claire Roddie, Jake Y. Henry, Hideo Yagita, Jedd D. Wolchok, Karl S. Peggs, Jeffrey V. Ravetch, James P. Allison and Sergio A. Quezada
July 29, 2013
Journal of Experimental Medicine online: July 29, 2013
Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood
Minji Byun, Cindy S. Ma, Arzu Akçay, Vincent Pedergnana, Umaimainthan Palendira, Jinjong Myoung, Danielle T. Avery, Yifang Liu, Avinash Abhyankar, Lazaro Lorenzo, Monika Schmidt, Hye Kyung Lim, Olivier Cassar, Melanie Migaud, Flore Rozenberg, Nur Canpolat, Gönül Aydoğan, Bernhard Fleckenstein, Jacinta Bustamante, Capucine Picard, Antoine Gessain10, Emmanuelle Jouanguy, Ethel Cesarman, Martin Olivier, Philippe Gros, Laurent Abel, Michael Croft, Stuart G. Tangye and Jean-Laurent Casanova
July 25, 2013
Science online: July 25, 2013
T follicular helper cell dynamics in germinal centers
Ziv Shulman, Alexander D. Gitlin, Sasha Targ, Mila Jankovic, Giulia Pasqual, Michel C. Nussenzweig and Gabriel D. Victora
July 23, 2013
Proceedings of the National Academy of Sciences USA online: July 23, 2013
Cost of rNTP/dNTP pool imbalance at the replication fork
Nina Y. Yao, Jeremy W. Schroeder, Olga Yurieva, Lyle A. Simmons and Mike E. O'Donnell
July 22, 2013
Proceedings of the National Academy of Sciences USA online: July 22, 2013
Bispecific antibodies directed to CD4 domain 2 and HIV envelope exhibit exceptional breadth and picomolar potency against HIV-1
Craig S. Pace, Ruijiang Song, Christina Ochsenbauer, Chasity D. Andrews, David Franco, Jian Yu, Deena A. Oren, Michael S. Seaman and David D. Ho
July 21, 2013
Nature Biotechnology online: July 21, 2013
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu, David A. Scott, Joshua A. Weinstein, F. Ann Ran, Silvana Konermann, Vineeta Agarwala, Yinqing Li, Eli J. Fine, Xuebing Wu, Ophir Shalem, Thomas J. Cradick, Luciano A. Marraffini, Gang Bao and Feng Zhang
July 19, 2013
The EMBO Journal online: July 19, 2013
SAMHD1-dependent retroviral control and escape in mice
Jan Rehwinkel, Jonathan Maelfait, Anne Bridgeman, Rachel Rigby, Bruce Hayward, Rachel A. Liberatore, Paul D. Bieniasz, Greg J. Towers, Luis F. Moita, Yanick J. Crow, David T. Bonthron and Caetano Reis e Sousa
July 18, 2013
Cell 154: 377-390
Marking and measuring single microtubules by PRC1 and kinesin-4
Radhika Subramanian, Shih-Chieh Ti, Lei Tan, Seth A. Darst and Tarun M. Kapoor
July 18, 2013
Cell 154: 297-310
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53
Zhanyun Tang, Wei-Yi Chen, Miho Shimada, Uyen T.T. Nguyen, Jaehoon Kim, Xiao-Jian Sun, Toru Sengoku, Robert K. McGinty, Joseph P. Fernandez, Tom W. Muir and Robert G. Roeder
July 16, 2013
Proceedings of the National Academy of Sciences USA 110: 11,797-11,802
Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products
Jeremy G. Owen, Boojala Vijay B. Reddy, Melinda A. Ternei, Zachary Charlop-Powers, Paula Y. Calle, Jeffrey H. Kim and Sean F. Brady
July 16, 2013
Cell online: July 16, 2013
KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors
Joshua C. Black, Amity L. Manning, Capucine Van Rechem, Jaegil Kim, Brendon Ladd, Juok Cho, Cristiana M. Pineda, Nancy Murphy, Danette L. Daniels, Cristina Montagna, Peter W. Lewis, Kimberly Glass, C. David Allis, Nicholas J. Dyson, Gad Getzsend and Johnathan R. Whetstine
July 15, 2013
Genes and Development 27: 1596-1609
A TAF4 coactivator function for E proteins that involves enhanced TFIID binding
Wei-Yi Chen, Jinsong Zhang, Huimin Geng, Zhimei Du, Tomoyoshi Nakadai and Robert G. Roeder
July 15, 2013
Proceedings of the National Academy of Sciences USA online: July 15, 2013
Structure and function of CarD, an essential mycobacterial transcription factor
Devendra B. Srivastava, Katherine Leon, Joseph Osmundson, Ashley L. Garner, Leslie A. Weiss, Lars F. Westblade, Michael S. Glickman, Robert Landick, Seth A. Darst, Christina L. Stallings and Elizabeth A. Campbell
July 9, 2013
Molecular Psychiatry online: July 9, 2013
Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition
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July 9, 2013
Immunity online: July 9, 2013
T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response
Eugenio A. Carrera Silva, Pamela Y. Chan, Leonel Joannas, Andrea E. Errasti, Nicola Gagliani, Lidia Bosurgi, Maurice Jabbour, Anthony Perry, Faye Smith-Chakmakova, Daniel Mucida, Hilde Cheroutre, Tal Burstyn-Cohen, Jonathan A. Leighton, Greg Lemke, Sourav Ghoshsend and Carla V. Rothlin
July 8, 2013
Proceedings of the National Academy of Sciences USA online: July 8, 2013
Stochastic expression and epigenetic memory at the yeast HO promoter
Qian Zhang, Youngdae Yoon, Yaxin Yu, Emily J. Parnell, Juan Antonio Raygoza Garay, Michael M. Mwangi, Frederick R. Cross, David J. Stillman and Lu Bai
July 2, 2013
PLoS Biology online: July 2, 2013
Quantitative control of protein s-palmitoylation regulates meiotic entry in fission yeast
Mingzi M. Zhang, Pei-Yun Jenny Wu, Felice D. Kelly, Paul Nurse and Howard C. Hang
July 1, 2013
Proceedings of the National Academy of Sciences USA online: July 1, 2013
Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II
Xin Liu, Tarun M. Kapoor, James K. Chen and Morgan Huse
July 1, 2013
Proceedings of the National Academy of Sciences USA online: July 1, 2013
Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells
Sonja C. Stadler, C. Theresa Vincent, Victor D. Fedorov, Antonia Patsialou, Brian D. Cherrington, Joseph J. Wakshlag, Sunish Mohanan, Barry M. Zee, Xuesen Zhang, Benjamin A. Garcia, John S. Condeelis, Anthony M. C. Brown, Scott A. Coonrod and C. David Allis
June 30, 2013
Nature online: June 30, 2013
A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis
Xiao-Jian Sun, Zhanxin Wang, Lan Wang, Yanwen Jiang, Nils Kost, T. David Soong, Wei-Yi Chen, Zhanyun Tang, Tomoyoshi Nakadai, Olivier Elemento, Wolfgang Fischle, Ari Melnick, Dinshaw J. Patel, Stephen D. Nimer and Robert G. Roeder
June 25, 2013
Proceedings of the National Academy of Sciences USA 110: 10,598-10,603
Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues
Anthony P. West, Jr., Louise Scharf, Joshua Horwitz, Florian Klein, Michel C. Nussenzweig and Pamela J. Bjorkman
June 20, 2013
Science online: June 20, 2013
Sept4/ARTS regulates stem cell apoptosis and skin regeneration
Yaron Fuchs, Samara Brown, Travis Gorenc, Joe Rodriguez, Elaine Fuchs and Hermann Steller
June 19, 2013
Developmental Cell online: June 19, 2013
Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis
Florence Tatin, Andrea Taddei, Anne Weston, Elaine Fuchs, Danelle Devenport, Fadel Tissir and Taija Makinen
June 17, 2013
Proceedings of the National Academy of Sciences USA online: June 17, 2013
Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform
Guillaume Charron, Melody M. H. Li, Margaret R. MacDonald and Howard C. Hang
June 13, 2013
Nature 498: 190-197
X-ray structure of the mammalian GIRK2-βγ G-protein complex
Matthew R. Whorton and Roderick MacKinnon
June 3, 2013
Nature Cell Biology 15: 546-554
Control of metastatic progression by microRNA regulatory networks
Nora Pencheva and Sohail F. Tavazoie
May 30, 2013
Cell online: May 30, 2013
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions
Elsa Callen, Michela Di Virgilio, Michael J. Kruhlak, Maria Nieto-Soler, Nancy Wong, Hua-Tang Chen, Robert B. Faryabi, Federica Polato, Margarida Santos, Linda M. Starnes, Duane R. Wesemann, Ji-Eun Lee, Anthony Tubbs, Barry P. Sleckman, Jeremy A. Daniel, Kai Ge, Frederick W. Alt, Oscar Fernandez-Capetillo, Michel C. Nussenzweig and André Nussenzweig
May 29, 2013
Nature online: May 29, 2013
orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET
Matthew DeGennaro, Carolyn S. McBride, Laura Seeholzer, Takao Nakagawa, Emily J. Dennis, Chloe Goldman, Nijole Jasinskiene, Anthony A. James and Leslie B. Vosshall
May 27, 2013
Journal of Experimental Medicine online: May 27, 2013
Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies
Ron Diskin, Florian Klein, Joshua A. Horwitz, Ariel Halper-Stromberg, D. Noah Sather, Paola M. Marcovecchio, Terri Lee, Anthony P. West Jr., Han Gao, Michael S. Seaman, Leonidas Stamatatos, Michel C. Nussenzweig and Pamela J. Bjorkman
May 26, 2013
Nature Immunology online: May 26, 2013
A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells
Eric L. Fritz, Brad R. Rosenberg, Kenneth Lay, Aleksandra Mihailović, Thomas Tuschl and F. Nina Papavasiliou
May 22, 2013
Proceedings of the National Academy of Sciences USA online: May 22, 2013
General mechanism for modulating immunoglobulin effector function
Peter Sondermann, Andrew Pincetic, Jad Maamary, Katja Lammens and Jeffrey V. Ravetch
May 20, 2013
Proceedings of the National Academy of Sciences USA online: May 20, 2013
Ultrastructural analysis of hepatitis C virus particles
Maria Teresa Catanese, Kunihiro Uryu, Martina Kopp, Thomas J. Edwards, Linda Andrus, William J. Rice, Mariena Silvestry, Richard J. Kuhn and Charles M. Rice
May 20, 2013
Proceedings of the National Academy of Sciences USA online: May 20, 2013
Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons
Emmanuelle Jordi, Myriam Heiman, Lucile Marion-Poll, Pierre Guermonprez, Shuk Kei Cheng, Angus C. Nairn, Paul Greengard and Jean-Antoine Girault
May 19, 2013
Nature Structural and Molecular Biology online: May 19, 2013
Preferential D-loop extension by a translesion DNA polymerase underlies error-prone recombination
Richard T. Pomerantz, Isabel Kurth, Myron F. Goodman and Mike E. O'Donnell
May 19, 2013
Nature Medicine online: May 19, 2013
Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection
Pierre Guermonprez, Julie Helft, Carla Claser, Stephanie Deroubaix, Henry Karanje, Anna Gazumyan, Guillaume Darasse-Jèze, Stephanie B. Telerman, Gaëlle Breton, Heidi A. Schreiber, Natalia Frias-Staheli, Eva Billerbeck, Marcus Dorner, Charles M. Rice, Alexander Ploss, Florian Klein, Melissa Swiecki, Marco Colonna, Alice O. Kamphorst, Matthew Meredith, Rachel Niec, Constantin Takacs, Fadi Mikhail, Aswin Hari, David Bosque, Tom Eisenreich, Miriam Merad, Yan Shi, Florent Ginhoux, Laurent Rénia, Britta C. Urban and Michel C. Nussenzweig
May 1, 2013
Cell online: May 1, 2013
Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
Pu Gao, Manuel Ascano, Yang Wu, Winfried Barchet, Barbara L. Gaffney, Thomas Zillinger, Artem A. Serganov, Yizhou Liu, Roger A. Jones, Gunther Hartmann, Thomas Tuschl and Dinshaw J. Patel
April 30, 2013
Molecular Psychiatry 18: 943-950
The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons
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April 25, 2013
Cell 153: 614-627
Proteasome regulation by ADP-ribosylation
Park F. Cho-Park and Hermann Steller
April 24, 2013
Nature online: April 24, 2013
Random convergence of olfactory inputs in the Drosophila mushroom body
Sophie J. C. Caron, Vanessa Ruta, L. F. Abbott and Richard Axel
April 11, 2013
Science online: April 11, 2013
Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia
Alexandre Bolze, Nizar Mahlaoui, Minji Byun, Bridget Turner, Nikolaus Trede, Steven R. Ellis, Avinash Abhyankar, Yuval Itan, Etienne Patin, Samuel Brebner, Paul Sackstein, Anne Puel, Capucine Picard, Laurent Abel, Lluis Quintana-Murci, Saul N. Faust, Anthony P. Williams, Richard Baretto, Michael Duddridge, Usha Kini, Andrew J. Pollard, Catherine Gaud, Pierre Frange, Daniel Orbach, Jean-Francois Emile, Jean-Louis Stephan, Ricardo Sorensen, Alessandro Plebani, Lennart Hammarstrom, Mary Ellen Conley, Licia Selleri and Jean-Laurent Casanova
April 4, 2013
Nature 496: 110-113
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
Hong Jiang, Saba Khan, Yi Wang, Guillaume Charron, Bin He, Carlos Sebastian, Jintang Du, Ray Kim, Eva Ge, Raul Mostoslavsky, Howard C. Hang, Quan Hao and Hening Lin
March 28, 2013
Cell 153: 126-138
Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization
Florian Klein, Ron Diskin, Johannes F. Scheid, Christian Gaebler, Hugo Mouquet, Ivelin S. Georgiev, Marie Pancera, Tongqing Zhou, Reha-Baris Incesu, Brooks Zhongzheng Fu, Priyanthi N.P. Gnanapragasam, Thiago Y. Oliveira, Michael S. Seaman, Peter D. Kwong, Pamela J. Bjorkman and Michel C. Nussenzweig
March 28, 2013
Molecular Cell 49:1121-1133
The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation
Jaehoon Kim, Jung-Ae Kim, Robert K. McGinty, Uyen T.T. Nguyen, Tom W. Muir, C. David Allis and Robert G. Roeder
March 28, 2013
Science online: March 28, 2013
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
Peter W. Lewis, Manuel M. Müller, Matthew S. Koletsky, Francisco Cordero, Shu Lin, Laura A. Banaszynski, Benjamin A. Garcia, Tom W. Muir, Oren J. Becher and C. David Allis
March 27, 2013
Proceedings of the National Academy of Sciences USA online: March 27, 2013
A phase transition in the first passage of a Brownian process through a fluctuating boundary with implications for neural coding
Thibaud Taillefumier and Marcelo O. Magnasco
March 27, 2013
Nature online: March 27, 2013
A solution to release twisted DNA during chromosome replication by coupled DNA polymerases
Isabel Kurth, Roxana E. Georgescu and Mike E. O'Donnell
March 22, 2013
Proceedings of the National Academy of Sciences USA online: March 22, 2013
Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody
Louise Scharf, Anthony P. West, Jr., Han Gao, Terri Lee, Johannes F. Scheid, Michel C. Nussenzweig, Pamela J. Bjorkman and Ron Diskin
March 18, 2013
Proceedings of the National Academy of Sciences USA online: March 18, 2013
The human gene connectome as a map of short cuts for morbid allele discovery
Yuval Itana, Shen-Ying Zhang, Guillaume Vogt, Avinash Abhyankar, Melina Herman, Patrick Nitschke, Dror Fried, Lluis Quintana-Murci, Laurent Abel and Jean-Laurent Casanova
March 18, 2013
Proceedings of the National Academy of Sciences USA online: March 18, 2013
Effects of cochlear loading on the motility of active outer hair cells
Dáibhid Ó Maoiléidigh and A. J. Hudspeth
March 18, 2013
Proceedings of the National Academy of Sciences USA online: March 18, 2013
RecA acts as a switch to regulate polymerase occupancy in a moving replication fork
Chiara Indiani, Meghna Patel, Myron F. Goodman and Mike E. O'Donnell
March 11, 2013
Proceedings of the National Academy of Sciences USA online: March 11, 2013
Ring cycle for dilating and constricting the nuclear pore
Sozanne R. Solmaz, Günter Blobel and Ivo Melcák
March 1, 2013
Nature Biotechnology 31: 233-239
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
Wenyan Jiang, David Bikard, David Cox, Feng Zhang and Luciano A Marraffini
February 28, 2013
Cell 152: 1021-1036
H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation
Shannon M. Lauberth, Takahiro Nakayama, Xiaolin Wu, Andrea L. Ferris, Zhanyun Tang, Stephen H. Hughes and Robert G. Roeder
February 25, 2013
Proceedings of the National Academy of Sciences USA online: February 25, 2013
Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations
Zev Williams, Iddo Z. Ben-Dov, Rony Elias, Aleksandra Mihailovic, Miguel Brown, Zev Rosenwaks and Thomas Tuschl
February 21, 2013
Genes and Development online: February 21, 2013
Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation
Jasbir Dalal, Jee Hoon Roh, Susan E. Maloney, Afua Akuffo, Samir Shah, Han Yuan, Brie Wamsley, Wendell B. Jones, Cristina de Guzman Strong, Paul A. Gray, David M. Holtzman, Nathaniel Heintz and Joseph D. Dougherty
February 19, 2013
Proceedings of the National Academy of Sciences USA online: February 19, 2013
Phenotypic model for early T-cell activation displaying sensitivity, specificity and antagonism
Paul François, Guillaume Voisinne, Eric D. Siggia, Grégoire Altan-Bonnet and Massimo Vergassola
February 19, 2013
Proceedings of the National Academy of Sciences USA online: February 19, 2013
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
Trent A. Watkins, Bei Wang, Sarah Huntwork-Rodriguez, Jing Yang, Zhiyu Jiang, Jeffrey Eastham-Anderson, Zora Modrusan, Joshua S. Kaminker, Marc Tessier-Lavigne and Joseph W. Lewcock
February 19, 2013
Proceedings of the National Academy of Sciences USA online: February 19, 2013
Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma
Michael Chiorazzi, Lixin Rui, Yandan Yang, Michele Ceribelli, Nima Tishbi, Carine W. Maurer, Stella M. Ranuncolo, Hong Zhao, Weihong Xu, Wing-Chung C. Chan, Elaine S. Jaffe, Randy D. Gascoyne, Elias Campo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa M. Rimsza, Shai Shaham and Louis M. Staudt
February 18, 2013
Current Biology 23: 328-332
Enforcement of reproductive synchrony via policing in a clonal ant
Serafino Teseo, Daniel J.C. Kronauer, Pierre Jaisson and Nicolas Châline
February 17, 2013
Nature Chemical Biology online: February 17, 2013
Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells
Scott Barbuto, Juliana Idoyaga, Miquel Vila-Perelló, Maria P. Longhi, Gaëlle Breton, Ralph M. Steinman and Tom W. Muir
February 14, 2013
Cell 152:831-843
SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action
Yong-Seok Oh, Pu Gao, Ko-Woon Lee, Ilaria Ceglia, Ji-Seon Seo, Xiaozhu Zhang, Jung-Hyuck Ahn, Brian T. Chait, Dinshaw J. Patel, Yong Kim and Paul Greengard
February 14, 2013
Proceedings of the National Academy of Sciences USA online: February 14, 2013
Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia
Eric Wang, Shinpei Kawaoka, Ming Yu, Junwei Shi, Ting Ni, Wenjing Yang, Jun Zhu, Robert G. Roeder and Christopher R. Vakoc
February 6, 2013
Nature online: February 6, 2013
NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche
Chiung-Ying Chang, H. Amalia Pasolli, Eugenia G. Giannopoulou, Géraldine Guasch, Richard M. Gronostajski, Olivier Elemento and Elaine Fuchs
February 4, 2013
Proceedings of the National Academy of Sciences USA online: February 4, 2013
Innate immunity receptor CD36 promotes cerebral amyloid angiopathy
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Proceedings of the National Academy of Sciences USA online: January 22, 2013
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Proceedings of the National Academy of Sciences USA online: January 22, 2013
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Nature Immunology online: January 20, 2013
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An optimized fluorescent probe for visualizing glutamate neurotransmission
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Science online: January 10, 2013
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Proceedings of the National Academy of Sciences USA online: January 9, 2013
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Dynamic persistence of antibiotic-stressed mycobacteria
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Proceedings of the National Academy of Sciences USA online: December 31, 2012
Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase
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Proceedings of the National Academy of Sciences USA 109: 21319-21324
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December 20, 2012
Nature 492: 382–386
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Proceedings of the National Academy of Sciences USA 109: 21076-21080
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Nature online: December 12, 2012
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
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Science 338: 1352-1353
Developmental progression to infectivity in Trypanosoma brucei triggered by an RNA-binding protein
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Neuron 76: 735-749
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Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies
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Nature Immunology online: October 28, 2012
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Nature online: October 28, 2012
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells
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Science online: October 26, 2012
Oxytocin/ vasopressin-related peptides have an ancient role in reproductive behavior
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Nature online: October 24, 2012
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
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Proceedings of the National Academy of Sciences USA 109: 17657-17662
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Nature Genetics 44: 1255-1259
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Nature online: October 17, 2012
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Proceedings of the National Academy of Sciences USA 109:16498-16503
Structural evolution of the membrane-coating module of the nuclear pore complex
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October 3, 2012
Nature online: October 3, 2012
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
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Nature Immunology online: September 23, 2012
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Neuron 75: 1067-1080
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Proceedings of the National Academy of Sciences USA online: September 17, 2012
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Nature online: September 9, 2012
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Neuron 75: 585-592
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Proceedings of the National Academy of Sciences USA online: August 20, 2012
Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro
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Cell 150: 764-779
The BMP inhibitor coco reactivates breast cancer cells at lung metastatic sites
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Cell Host & Microbe 12: 177-186
CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection
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August 13, 2012
Proceedings of the National Academy of Sciences USA online: August 13, 2012
Structural investigations of a Podoviridae streptococcus phage C1, implications for the mechanism of viral entry
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Neuron 75: 437-450
Muscleblind-like 2-Mediated Alternative Splicing in the Developing Brain and Dysregulation in Myotonic Dystrophy
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The Journal of Experimental Medicine online: August 7, 2012
Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood
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Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling
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August 2, 2012
Science online: August 2, 2012
Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency
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The Journal of Clinical Investigation online: August 1, 2012
Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections
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Molecular Cell online: July 26, 2012
DNA methylation dynamics during in vivo differentiation of blood and skin stem cells
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Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein
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July 17, 2012
Proceedings of the National Academy of Sciences USA online: July 17, 2012
X-ray crystal structure of the streptococcal specific phage lysin PlyC
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Proceedings of the National Academy of Sciences USA online: July 17, 2012
Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis
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July 17, 2012
Proceedings of the National Academy of Sciences USA 109: 11699-11704
Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters
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July 15, 2012
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Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain
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July 15, 2012
Nature Structural & Molecular Biology online: July 15, 2012
Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events
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Proceedings of the National Academy of Sciences USA online: July 11, 2012
Speed, dissipation, and error in kinetic proofreading
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July 10, 2012
Molecular Psychiatry online: July 10, 2012
Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure
MN Hill, SA Kumar, SB Filipski, M Iverson, KL Stuhr, JM Keith, BF Cravatt, CJ Hillard, S Chattarji and BS McEwen
July 8, 2012
Nature Genetics online: July 8, 2012
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair
Weibin Zhou, Edgar A Otto, Andrew Cluckey, Rannar Airik, Toby W Hurd, Moumita Chaki, Katrina Diaz, Francis P Lach, Geoffrey R Bennett, Heon Yung Gee, Amiya K Ghosh, Sivakumar Natarajan, Supawat Thongthip, Uma Veturi, Susan J Allen, Sabine Janssen, Gokul Ramaswami, Joanne Dixon, Felix Burkhalter, Martin Spoendlin, Holger Moch, Michael J Mihatsch, Jerome Verine, Richard Reade, Hany Soliman, Michel Godin, Denes Kiss, Guido Monga, Gianna Mazzucco, Kerstin Amann, Ferruh Artunc, Ronald C Newland, Thorsten Wiech, Stefan Zschiedrich, Tobias B Huber, Andreas Friedl, Gisela G Slaats, Jaap A Joles, Roel Goldschmeding, Joseph Washburn, Rachel H Giles, Shawn Levy, Agata Smogorzewska and Friedhelm Hildebrandt
July 8, 2012
Nature Neuroscience online: July 8, 2012
Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth
Erik Mire, Cecilia Mezzera, Eduardo Leyva-Díaz, Ana V Paternain, Paola Squarzoni, Lisa Bluy, Mar Castillo-Paterna, María José López, Sandra Peregrín, Marc Tessier-Lavigne, Sonia Garel, Joan Galcerán, Juan Lerma and Guillermina López-Bendito
July 6, 2012
Cell 150: 136-150
Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair
Catherine P. Lu, Lisa Polak, Ana Sofia Rocha, H. Amalia Pasolli, Shann-Ching Chen, Neha Sharma, Cedric Blanpain and Elaine Fuchs
July 6, 2012
Cell 150: 39-52
Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST
Peng Wu, Hiroyuki Takai and Titia de Lange
June 30, 2012
The Lancet 379: 2500
Herpes in STAT1 deficiency
Beáta Tóth, Leonóra Méhes, Szilvia Taskó, Zsuzsanna Szalai, Zsolt Tulassay, Sophie Cypowyj, Jean-Laurent Casanova, Anne Puel and László Maródi
June 26, 2012
Proceedings of the National Academy of Sciences USA 109: 10564-10569
Scale invariance in the dynamics of spontaneous behavior
Alex Proekt, Jayanth R. Banavar, Amos Maritan and Donald W. Pfaff
June 26, 2012
Proceedings of the National Academy of Sciences USA 109: 10352-10357
Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels
Daniel Schmidt, Josefina del Mármol and Roderick MacKinnon
June 25, 2012
Proceedings of the National Academy of Sciences USA online: June 25, 2012
Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior
Jennifer L. Warner-Schmidt, Eric F. Schmidt, John J. Marshall, Amanda J. Rubin, Margarita Arango-Lievano, Michael G. Kaplitt, Ines Ibañez-Tallon, Nathaniel Heintz and Paul Greengard
June 22, 2012
Cell 149: 1565-1577
Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation
Xinjun Zhang, Jose Garcia Abreu, Chika Yokota, Bryan T. MacDonald, Sasha Singh, Karla Loureiro Almeida Coburn, Seong-Moon Cheong, Mingzi M. Zhang, Qi-Zhuang Ye, Howard C. Hang, Hanno Steen and Xi He
June 20, 2012
Proceedings of the National Academy of Sciences USA online: June 20, 2012
Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcγ receptor engagement
Fubin Li and Jeffrey V. Ravetch
June 18, 2012
Proceedings of the National Academy of Sciences USA online: June 18, 2012
Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation
Alexander L. Kovalchuk, Camilo Ansarah-Sobrinho, Ofir Hakim, Wolfgang Resch, Helena Tolarová, Wendy Dubois, Arito Yamane, Makiko Takizawa, Isaac Klein, Gordon L. Hager, Herbert C. Morse III, Michael Potter, Michel C. Nussenzweig and Rafael Casellas
June 12, 2012
Cancer Cell 21: 765-766
Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells
Teresa Davoli and Titia de Lange
June 11, 2012
Proceedings of the National Academy of Sciences USA online: June 11, 2012
Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4
Aryeh Warmflash, Qixiang Zhang, Benoit Sorre, Alin Vonica, Eric D. Siggia and Ali H. Brivanlou
June 7, 2012
Science online: June 7, 2012
dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
Jeannette M. Osterloh, Jing Yang, Timothy M. Rooney, A. Nicole Fox, Robert Adalbert, Eric H. Powell, Amy E. Sheehan, Michelle A. Avery, Rachel Hackett, Mary A. Logan, Jennifer M. MacDonald, Jennifer S. Ziegenfuss, Stefan Milde, Ying-Ju Hou, Carl Nathan, Aihao Ding, Robert H. Brown Jr., Laura Conforti, Michael Coleman, Marc Tessier-Lavigne, Stephan Züchner and Marc R. Freeman
May 25, 2012
Cell 149: 1164-1173
Contingency and statistical laws in replicate microbial closed ecosystems
Doeke R. Hekstra and Stanislas Leibler
May 25, 2012
Cell 149: 1152-1163
Identification of the Cortical Neurons that Mediate Antidepressant Responses
Eric F. Schmidt, Jennifer L. Warner-Schmidt, Benjamin G. Otopalik, Sarah B. Pickett, Paul Greengard and Nathaniel Heintz
May 21, 2012
Journal of Experimental Medicine online: May 21, 2012
Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage
Matthew M. Meredith, Kang Liu, Guillaume Darrasse-Jeze, Alice O. Kamphorst, Heidi A. Schreiber, Pierre Guermonprez, Juliana Idoyaga, Cheolho Cheong, Kai-Hui Yao, Rachel E. Niec and Michel C. Nussenzweig
May 15, 2012
The EMBO Journal online: May 15, 2012
A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis
Ruth Simon, Heike Brylka, Herbert Schwegler, Sathish Venkataramanappa, Jacqueline Andratschke, Christoph Wiegreffe, Pentao Liu, Elaine Fuchs, Nancy A Jenkins, Neal G Copeland, Carmen Birchmeier and Stefan Britsch
May 15, 2012
Developmental Cell 22: 913-926
Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module
Matthew Koss, Alexandre Bolze, Andrea Brendolan, Matilde Saggese, Terence D. Capellini, Ekaterina Bojilova, Bertrand Boisson, Owen W.J. Prall, David A. Elliott, Mark Solloway, Elisa Lenti, Chisa Hidaka, Ching-Pin Chang, Nizar Mahlaoui, Richard P. Harvey, Jean-Laurent Casanova, Licia Selleri
May 7, 2012
Journal of Experimental Medicine 209: 1011-1028
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice
Fabienne Billiard, Camille Lobry, Guillaume Darrasse-Jèze, Janelle Waite, Xia Liu, Hugo Mouquet, Amanda DaNave, Michelle Tait, Juliana Idoyaga, Marylène Leboeuf, Christos A. Kyratsous, Jacquelynn Burton, Julie Kalter, Apostolos Klinakis, Wen Zhang, Gavin Thurston, Miriam Merad, Ralph M. Steinman, Andrew J. Murphy, George D. Yancopoulos, Iannis Aifantis and Dimitris Skokos
May 4, 2012
Science 336: 593-597
Removal of shelterin reveals the telomere end-protection problem
Agnel Sfeir and Titia de Lange
May 4, 2012
Science 336: 604-608
Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice
Sarah A. Stanley, Jennifer E. Gagner, Shadi Damanpour, Mitsukuni Yoshida, Jonathan S. Dordick and Jeffrey M. Friedman
April 17, 2012
Nature online: April 4, 2012
An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration
Ting Chen, Evan Heller, Slobodan Beronja, Naoki Oshimori, Nicole Stokes and Elaine Fuchs
April 17, 2012
Proceedings of the National Academy of Sciences USA 109: 6205-6210
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
Erick Giang, Marcus Dorner, Jannick C. Prentoe, Marlène Dreux, Matthew J. Evans, Jens Bukh, Charles M. Rice, Alexander Ploss, Dennis R. Burton and Mansun Law
April 17, 2012
Proceedings of the National Academy of Sciences USA 109: 6181-6186
Mouse model recapitulating human Fcγ receptor structural and functional diversity
Patrick Smith, David J. DiLillo, Stylianos Bournazos,Fubin Li and Jeffrey V. Ravetch
April 17, 2012
Proceedings of the National Academy of Sciences USA 109: 6072-6077
RNA ligase RtcB splices 3′-phosphate and 5′-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3′)pp(5′)G intermediates
Anupam K. Chakravartya, Roman Subbotin, Brian T. Chait and
Stewart Shuman
April 17, 2012
Proceedings of the National Academy of Sciences USA 109: 6175-6180
Viral-induced encephalitis initiates distinct and functional CD103+ CD11b+ brain dendritic cell populations within the olfactory bulb
Paul M. D'Agostinoa, Changsoo Kwaka, Haley A. Vecchiarellia, Judit Gal Totha, James M. Millera, Zahrah Masheeba, Bruce S. McEwen and Karen Bulloch
April 10, 2012
Proceedings of the National Academy of Sciences USA 109: 5779-5784
Mutagenesis of pairwise combinations of histone amino-terminal tails reveals functional redundancy in budding yeast
Jung-Ae Kima, Jer-Yuan Hsub, M. Mitchell Smithb and C. David Allis
April 1, 2012
Genes & Development 26: 693-704
Quantitative functions of Argonaute proteins in mammalian development
Dongmei Wang, Zhaojie Zhang, Evan O'Loughlin, Thomas Lee, Stephane Houel, Dónal O'Carroll, Alexander Tarakhovsky, Natalie G. Ahn and Rui Yi
March 30, 2012
Science 335: 1617–1621
Control of sleep by cyclin A and its regulator
Dragana Rogulja and Michael W. Young
We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and reduced the homeostatic response to sleep deprivation.
March 29, 2012
New England Journal of Medicine 366: 1181–1189
Brodalumab, an anti–interleukin-17–receptor antibody for psoriasis
Kim A. Papp, Craig Leonardi, Alan Menter, Jean-Paul Ortonne, James G. Krueger, Gregory Kricorian, Girish Aras, Juan Li, Chris B. Russell, Elizabeth H.Z. Thompson, and Scott Baumgartner
We assessed the efficacy and safety of brodalumab (AMG 827), a human anti-interleukin-17-receptor monoclonal antibody, for the treatment of moderate-to-severe plaque psoriasis. An improvement of at least 75% and at least 90% in the PASI score at week 12 was seen in 77% and 72%, respectively, of the patients in the 140-mg brodalumab group and in 82% and 75%, respectively, of the patients in the 210-mg group, as compared with 0% in the placebo group (P<0.001 for all comparisons). Brodalumab significantly improved plaque psoriasis in this 12-week, phase 2 study.
March 18, 2012
Nature online: March 18, 2012
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
Ari J. Firestone, Joshua S. Weinger, Maria Maldonado, Kari Barlan, Lance D. Langston, Michael O'Donnell, Vladimir I. Gelfand, Tarun M. Kapoor and James K. Chen
We describe the discovery of ciliobrevins, the first specific small-molecule antagonists of cytoplasmic dynein. Ciliobrevins perturb protein trafficking within the primary cilium, leading to their malformation and Hedgehog signalling blockade. Ciliobrevins also prevent spindle pole focusing, kinetochore-microtubule attachment, melanosome aggregation and peroxisome motility in cultured cells. We further demonstrate the ability of ciliobrevins to block dynein-dependent microtubule gliding and ATPase activity in vitro.
March 14, 2012
Nature 483: 428–433
Suppression of the antiviral response by an influenza histone mimic
Ivan Marazzi, Jessica S. Y. Ho, Jaehoon Kim, Balaji Manicassamy, Scott Dewell, Randy A. Albrecht, Chris W. Seibert, Uwe Schaefer, Kate L. Jeffrey, Rab K. Prinjha, Kevin Lee, Adolfo García-Sastre, Robert G. Roeder and Alexander Tarakhovsky
We describe a novel mechanism by which influenza virus affects host cells through the interaction of influenza non-structural protein 1 (NS1) with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 subtype possesses a histone-like sequence (histone mimic) that is used by the virus to target the human PAF1 transcription elongation complex (hPAF1C). We demonstrate that binding of NS1 to hPAF1C depends on the NS1 histone mimic and results in suppression of hPAF1C-mediated transcriptional elongation.
March 12, 2012
Journal of Experimental Medicine 209: 661-669
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response
Terry C. Fang, Uwe Schaefer, Ingrid Mecklenbrauker, Astrid Stienen, Scott Dewell, Marie S. Chen, Inmaculada Rioja, Valentino Parravicini, Rab K. Prinjha, Rohit Chandwani, Margaret R. MacDonald, Kevin Lee, Charles M. Rice and Alexander Tarakhovsky
Effective antiviral immunity depends on the ability of infected cells or cells triggered with virus-derived nucleic acids to produce type I interferon (IFN), which activates transcription of numerous antiviral genes. However, disproportionately strong or chronic IFN expression is a common cause of inflammatory and autoimmune diseases. We describe an epigenetic mechanism that determines cell type–specific differences in IFN and IFN-stimulated gene (ISG) expression in response to exogenous signals.
February 24, 2012
Science 335: 970–973
Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein
Elyse S. Blum, Mary C. Abraham, Satoshi Yoshimura, Yun Lu and Shai Shaham
In Caenorhabditis elegans, programmed death of the linker cell, which leads gonadal elongation, proceeds independently of caspases and apoptotic effectors. To identify genes promoting linker-cell death, we performed a genome-wide RNA interference screen. We show that linker-cell death requires the gene pqn-41, encoding an endogenous polyglutamine-repeat protein.
February 7, 2012
Nature online: February 7, 2012
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes
Ofir Hakim, Wolfgang Resch, Arito Yamane, Isaac Klein, Kyong-Rim Kieffer-Kwon, Mila Jankovic, Thiago Oliveira, Anne Bothmer, Ty C. Voss, Camilo Ansarah-Sobrinho, Ewy Mathe, Genqing Liang, Jesse Cobell, Hirotaka Nakahashi, Davide F. Robbiani, Andre Nussenzweig, Gordon L. Hager, Michel C. Nussenzweig and Rafael Casellas
In the absence of recurrent DNA damage, translocations between Igh or Myc and all other genes are directly related to their contact frequency. Conversely, translocations associated with recurrent site-directed DNA damage are proportional to the rate of DNA break formation, as measured by replication protein A accumulation at the site of damage.
January 27, 2012
Science 335: 436–441
Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel
Stephen G. Brohawn, Josefina del Mármol and Roderick MacKinnon
We present the crystal structure of human TRAAK at a resolution of 3.8 angstroms. The channel comprises two protomers, each containing two distinct pore domains, which create a two-fold symmetric K+ channel. The extracellular surface features a helical cap, 35 angstroms tall, that creates a bifurcated pore entryway and accounts for the insensitivity of two–pore domain K+ channels to inhibitory toxins. Two diagonally opposed gate-forming inner helices form membrane-interacting structures that may underlie this channel's sensitivity to chemical and mechanical properties of the cell membrane.
January 22, 2012
Nature Genetics online: January 22, 2012
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
Paul Delgado-Olguín, Yu Huang, Xue Li, Danos Christodoulou, Christine E. Seidman, J.G. Seidman, Alexander Tarakhovsky and Benoit G. Bruneau
We show that Ezh2 stabilizes cardiac gene expression and prevents cardiac pathology by repressing the homeodomain transcription factor gene Six1, which functions in cardiac progenitor cells but is stably silenced upon cardiac differentiation. Our results suggest that epigenetic dysregulation in embryonic progenitor cells is a predisposing factor for adult disease and dysregulated stress responses.
January 6, 2012
Cell Stem Cell 10: 63–75
Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation
Naoki Oshimori and Elaine Fuchs
Hair follicle (HF) regeneration begins when communication between quiescent epithelial stem cells (SCs) and underlying mesenchymal dermal papillae (DP) generates sufficient activating cues to overcome repressive BMP signals from surrounding niche cells. Here, we uncover a hitherto unrecognized DP transmitter, TGF-β2, which activates Smad2/3 transiently in HFSCs concomitant with entry into tissue regeneration.
December 25, 2011
Nature Immunology online: December 25, 2011
B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen
Irene Puga, Montserrat Cols, Carolina M. Barra, Bing He, Linda Cassis, Maurizio Gentile, Laura Comerma, Alejo Chorny, Meimei Shan, Weifeng Xu, Giuliana Magri, Daniel M. Knowles, Wayne Tam, April Chiu, James B. Bussel, Sergi Serrano, José Antonio Lorente, Beatriz Bellosillo, Josep Lloreta, Nuria Juanpere, Francesc Alameda, Teresa Baró, Cristina Díaz de Heredia, Núria Torán, Albert Català, Montserrat Torrebadell, Claudia Fortuny, Victoria Cusí, Carmen Carreras, George A. Diaz, J Magarian Blander, Claire-Michèle Farber, Guido Silvestri, Charlotte Cunningham-Rundles, Michaela Calvillo, Carlo Dufour, Lucia Dora Notarangelo, Vassilios Lougaris, Alessandro Plebani, Jean-Laurent Casanova, Stephanie C. Ganal, Andreas Diefenbach, Juan Ignacio Aróstegui, Manel Juan, Jordi Yagüe, Nizar Mahlaoui, Jean Donadieu, Kang Chen and Andrea Cerutti
Neutrophils use immunoglobulins to clear antigen, but their role in immunoglobulin production is unknown. Here we identified neutrophils around the marginal zone (MZ) of the spleen, a B cell area specialized in T cell–independent immunoglobulin responses to circulating antigen.
December 23, 2011
Cell 147: 1615–1627
The functional organization of cutaneous low-threshold mechanosensory neurons
Lishi Li, Michael Rutlin, Victoria E. Abraira, Colleen Cassidy, Laura Kus, Shiaoching Gong, Michael P. Jankowski, Wenqin Luo, Nathaniel Heintz, H. Richard Koerber, C. Jeffery Woodbury and David D. Ginty
Here, we report genetic labeling of LTMR subtypes and visualization of their relative patterns of axonal endings in hairy skin and the spinal cord. We found that each of the three major hair follicle types of trunk hairy skin (guard, awl/auchene, and zigzag hairs) is innervated by a unique and invariant combination of LTMRs; thus, each hair follicle type is a functionally distinct mechanosensory end organ.
December 23, 2011
Science 344: 1675–1680
How a DNA polymerase clamp loader opens a sliding clamp
Brian A. Kelch, Debora L. Makino, Mike O'Donnell and John Kuriyan
We present structures for the ATP-bound state of the clamp loader complex from bacteriophage T4, bound to an open clamp and primer-template DNA. The structures explain how synergy among the loader, the clamp, and DNA can trigger ATP hydrolysis and release of the closed clamp on DNA.
December 14, 2011
Nature online: December 14, 2011
A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells
Kim J. Png, Nils Halberg, Mitsukuni Yoshida and Sohail F. Tavazoie
Here we reveal that endogenous miR-126, an miRNA silenced in a variety of common human cancers, non-cell-autonomously regulates endothelial cell recruitment to metastatic breast cancer cells, in vitro and in vivo. Through loss-of-function and epistasis experiments, we delineate an miRNA regulatory network's individual components as novel and cell-extrinsic regulators of endothelial recruitment, angiogenesis and metastatic colonization.
December 11, 2011
Nature Genetics online: December 11, 2011
Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome
Carine Le Goff, Clémentine Mahaut, Avinash Abhyankar, Wilfried Le Goff, Valérie Serre, Alexandra Afenjar, Anne Destrée, Maja di Rocco, Delphine Héron, Sébastien Jacquemont, Sandrine Marlin, Marleen Simon, John Tolmie, Alain Verloes, Jean-Laurent Casanova, Arnold Munnich and Valérie Cormier-Daire
Using exome sequencing of individuals with Myhre syndrome, we identified SMAD4 as a candidate gene that contributes to this syndrome on the basis of its pivotal role in the bone morphogenetic pathway (BMP) and transforming growth factor (TGF)-β signaling. We identified three distinct heterozygous missense SMAD4 mutations affecting the codon for Ile500 in 11 individuals with Myhre syndrome.
December 4, 2011
Nature online: December 4, 2011
Open Structure of the Ca(2+) Gating Ring in the High-conductance Ca(2+)-activated K(+) Channel
Peng Yuan, Manuel D. Leonetti, Yichun Hsiung and Roderick MacKinnon
Here we present the Ca(2+)-bound conformation of the gating ring. This structure shows how one layer of the gating ring, in response to the binding of Ca(2+), opens like the petals of a flower. The degree to which it opens explains how Ca(2+) binding can open the transmembrane pore. These findings present a molecular basis for Ca(2+) activation of K(+) channels and suggest new possibilities for targeting the gating ring to treat conditions such as asthma and hypertension.
November 30, 2011
Cell online: November 30, 2011
Structural Basis for Promoter −10 Element Recognition by the Bacterial RNA Polymerase σ Subunit
Andrey Feklistov and Seth A. Darst
We determined crystal structures of σ domain 2 bound to single-stranded DNA bearing -10 element sequences. The structures, along with biochemical data, support a model where the recognition of the -10 element sequence drives initial promoter opening as the bases of the nontemplate strand are extruded from the DNA double-helix and captured by σ.
November 27, 2011
Nature online: November 27, 2011
GlcNAcylation of Histone H2B Facilitates its Monoubiquitination
Ryoji Fujiki, Waka Hashiba, Hiroki Sekine, Atsushi Yokoyama, Toshihiro Chikanishi, Saya Ito, Yuuki Imai, Jaehoon Kim, Housheng Hansen He, Katsuhide Igarashi, Jun Kanno, Fumiaki Ohtake, Hirochika Kitagawa, Robert G. Roeder, Myles Brown and Shigeaki Kato
In a genome-wide analysis, H2B S112 GlcNAcylation sites were observed widely distributed over chromosomes including transcribed gene loci, with some sites co-localizing with H2B K120 monoubiquitination. These findings suggest that H2B S112 GlcNAcylation is a histone modification that facilitates H2BK120 monoubiquitination, presumably for transcriptional activation.
November 23, 2011
Immunity 35: 819–831
Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis
Jae-Hoon Choi, Cheolho Cheong, Durga B. Dandamudi, Chae Gyu Park, Anthony Rodriguez, Saurabh Mehandru, Klara Velinzon, In-Hyuk Jung, Ji-Young Yoo, Goo Taeg Oh and Ralph M. Steinman
Early events in atherosclerosis occur in the aortic intima and involve monocytes that become macrophages. We looked for these cells in the steady state adult mouse aorta, and surprisingly, we found a dominance of dendritic cells (DCs) in the intima.
November 13, 2011
Nature online: November 13, 2011
Structure of full-length Drosophila cryptochrom
Brian D. Zoltowski, Anand T. Vaidya, Deniz Top, Joanne Widom, Michael W. Young and Brian R. Crane
Here, we report a 2.3-Å resolution crystal structure of Drosophila CRY with an intact C terminus. The C-terminal helix docks in the analogous groove that binds DNA substrates in PLs. Conserved Trp 536 juts into the CRY catalytic centre to mimic PL recognition of DNA photolesions. The FAD anionic semiquinone found in the crystals assumes a conformation to facilitate restructuring of the tail helix. These results help reconcile the diverse functions of the CRY/PL family by demonstrating how conserved protein architecture and photochemistry can be elaborated into a range of light-driven functions.
October 28, 2011
Cell 147: 590–602
Molecular Architecture of the Transport Channel of the Nuclear Pore Complex
Sozanne R. Solmaz, Radha Chauhan, Günter Blobel and Ivo Melčák
The nuclear pore complex encloses a central channel for nucleocytoplasmic transport, which is thought to consist of three nucleoporins, Nup54, Nup58, and Nup62. However, the structure and composition of the channel are elusive. We determined the crystal structures of the interacting domains between these nucleoporins and pieced together the molecular architecture of the mammalian transport channel.
September 30, 2011
Cell 147: 199–208
Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium
Matthew R. Whorton and Roderick MacKinnon
Here, we present the first crystal structures of a G protein-gated K+ channel. By comparing the wild-type structure to that of a constitutively active mutant, we identify a global conformational change through which G proteins could open a G loop gate in the cytoplasmic domain. These data provide a structural basis for understanding multiligand regulation of GIRK channel gating.
The prize, awarded by MIT's McGovern Institute, honors outstanding achievements in neuroscience. It recognizes Gilbert's work on visual perception and brain plasticity. More »
Researchers found that exposure to the signal TGF-β causes changes in mouse tumor stem cells that help them evade a widely used anti-cancer drug. This did not happen to cells that did not receive TGF-β. More »
Researchers have employed a recently developed technique to capture how a viral protein, Gag, selectively extracts and packages viral RNA into the viral particles that exported to new cells. More »
The enzyme Cas9 is well known for its ability to make precise cuts in a genome. New research reveals a new role for Cas9 in its native bacteria: helping the microbial immune system acquire a memory of an invading virus. More »
Researchers have found that the immune system fights a flu infection by turning off cellular enzymes the virus needs to put the final touches on new viral particles. The unfinished particles cannot spread infection to new cells. More »
As part of an effort to identify DNA found throughout New York City, students in Rockefeller's Science Outreach Program have been swabbing surfaces in the subway system. Their work has turned up bacteria resistant to two common antibiotics. More »
Considered one of the most prestigious prizes in medicine, the Wolf Prize recognizes Ravetch's work on the molecular basis of the immune response, including the Fc receptor system that mediates antibody function in disease and health. More »
When researchers sequenced and compared sites where the virus had integrated into the genomes of infected CD4 T cells, they found evidence dormant but dangerous HIV was hiding out in cells that had never been copied – not the more abundant cloned cells. More »
By identifying genes that become activated in cancer cells that successfully metastasize to the liver, researchers at Rockefeller have implicated metabolic processes within the liver as a possible means by which starving transient cancer cells can go on to form deadly new colonies. More »
Experiments show that a protein already implicated in degeneration, called Sarm1, functions to trigger the MAP kinase pathway. Inactivation of this pathway at any of three levels could block the death of damaged axons.
More »
Tavazoie, who joined Rockefeller in 2009, works to understand how cancer cells become able to escape a tumor and invade other organs, a process known as metastasis. He searches for genes and molecular pathways cancer cells exploit in order to metastasize and, with that knowledge, hopes to develop future treatments to prevent or interfere with the process.
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Because cabotegravir would require only one injection every three months, researchers hope this new drug, which has begun clinical testing, could improve some patients' ability to take HIV prevention medication properly. More »
Paul Cohen, a molecular biologist and cardiologist, is returning to Rockefeller where he did his graduate work. In his new lab, Cohen will study the molecular origins of obesity-related metabolic disease with the goal of developing treatments. More »
Like humans, rhesus macaque monkeys have a network of small tareas within their brains that respond to images of faces. New research shows these so-called face patches also respond selectively to changing expressions and other facial motion. More »
Rockefeller University scientists Jeffrey M. Friedman and Leslie B. Vosshall have been awarded the distinction of AAAS Fellow. Election as a fellow is an honor bestowed upon AAAS members by their peers. More »
After experiments showed treatment prevented normal decline in aging rats' spatial memory, researchers found changes known to improve connections, and as a result, communication, between certain neurons within the brain's hippocampus. More »
A team is developing a system that would make it possible to remotely control biological targets in living animals — rapidly, without wires, implants or drugs. During a test, they used radio waves or a magnetic field to turn on insulin production in mice. More »
New research links stem cell metabolism with those cells' decision to pick a fate or renew themselves. In experiments, exposure to a key metabolite called alpha-ketoglutarate enhanced the renewal of mouse embryonic stem cells. More »
The Community Acquired MRSA Project ("CAMP2″) will enroll patients with skin infections, provide English- and Spanish-language health education materials about community-acquired drug-resistant staph infections, and incorporate a home visit program by community health workers to evaluate the effectiveness of household decontamination in preventing reinfection and transmission. More »
An ion channel responsible for dampening potentially painful sensations uses a never-before-seen mechanism to shut itself off: A lipid from the nearby cellular membrane protrudes into the channel, blocking it. More »