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13:00 28 February 2015
Being trustworthy and accurate could help a web page rise up Google rankings if the search engine giant starts to measure quality by facts, not just links
20:00 27 February 2015
Global intervention in tropical forests to combat climate change could sideline their most effective guardians, warns Fred Pearce
19:00 27 February 2015
Satellite images of the Amazon show that deforestation in Brazil has, at points, risen to levels 467 per cent of last year's
18:00 27 February 2015
As eight die in shootings in Missouri, US organisations have banded together against a law compelling psychiatrists to report patients with mental illness
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Split-suede leather materials allow for longer wear and durability
High-cut profile for increased ankle support, stability and protection
Material bridge connects tongue to the upper eliminating debris from entering the shoe.
Provides rearfoot stability and protection.
Delivering optimal traction on varied surfaces, Salomon's Contagrip® outsoles use the ideal combination of specialized rubbers for each specific use
Salomon's lightweight advanced chassis, placed between the outsole and midsole, maximizes motion control, energy management and push through protection for an efficient, stable and responsive ride.
Specific material on the toe cap to provide protection
Protective material all around the base of the shoe
3D open mesh that provides maximum breathability.
Waterproof and breathable bootie construction.
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Get on the list for product trends coupons and special offers.
This is a luxuriously comfortable panty. Say goodbye to panty lines and enjoy this everyday hiphugger. Its smooth stretch DuraFit™ fabric and thermofusion process make this panty completely imperceptible under your clothes. You won't even remember you have it on.
it's very good, but would be better if it came in more colors
1 out of 1 found this review helpful. Did this review help? Yes No
Super invisible!! this is the best panty I ever bought.
When I read the ad I didn't believe it, but I decided to buy one, it surprised me because it's no show, it doesn't ride-up, and it feels extra comfortable and it fits well under my clothes, excellent!
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It's absolute that you will adore it! Heavenly comfort underwire with perfect-shape triangle cups. Fasten up and feel its secure and supported fit. No rolls about it - the double layered thermofusion feature polishes those bulges; its cups have good coverage, and provide the best support and help lift the bust for a natural look. Enjoy a marvelous bust shape. Its adhesive film with memory helps the bra maintain its place offering extra support so you can feel relaxed and comfortable throughout the day.
Im a large chested women, naturaly . So i love this bra i have 3 now
7 out of 8 found this review helpful. Did this review help? Yes No
Keep dreaming bigger? Pinch yourself, you are awake; the push up bra of your dreams is now available at Leonisa! Incredible design - no air pads, no removable gel or foam padding. A dramatic lift but with natural shape. Light, smooth and soft on skin for an invisible appearance. Cups are made of an innovative memory form, a light incorporated foam that forms and adapts well to your body and has the ability to recuperate its original form after you wear it. Amaze yourself and others with a bust - 2 cup sizes bigger.
It´s so comfortable that I can even sleep with it. And BTW it does adds two cups. WOW
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Love the bra its a dream to wear made all my low cut dresses look so hot.
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ojala funcione soy mas plana q una tabla :/
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Mike Brown 1-on-1 with John Michael
CavsTV and John Michael caught up with Cavaliers Head Coach Mike Brown at the Ronald McDonald House on the East Side of Cleveland to discuss the community event, 2013 NBA Draft and more.


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Hamburg sign Johan Djourou on a permanent deal after they activated a buying clause in his loan deal from Arsenal.
Oliver Kreuzer has pulled the plug on contract negotiations as Hamburg focus on Bundesliga survival.
Switzerland defender Johan Djourou would be open to a permanent move from Arsenal to Hamburg in the summer.
Johan Djourou has been ruled out for several weeks with a torn muscle in his groin, Hamburg have confirmed.
Hamburg have signed Switzerland defender Johan Djourou on loan from Arsenal.
Hannover 96 general manager Dirk Dufner says that positive talks have been held with Arsenal defender Johan Djourou.
Hamburg are keen to bring Arsenal defender Johan Djourou back to the Bundesliga.
Arsenal's Johan Djourou will speak with Hannover's management over his future in the next few days, says his agent.
Johan Djourou admits he would be willing to make his loan switch from Arsenal to Hannover permanent in the summer.
Arsenal and Switzerland defender Johan Djourou has agreed to join Hannover 96 on loan for the remainder of the season.
Hannover have confirmed that they are hopeful of sealing a deal for Arsenal defender Johan Djourou.
Hannover have admitted they are interested in bringing Arsenal defender Johan Djourou to the Bundesliga.
Johan Djourou's agent believes the Switzerland international would be an ideal signature for Napoli.
The agent of Arsenal's Johan Djourou has played down reports linking the defender with a move to Napoli.
The agent of versatile Arsenal defender Johan Djourou admits his client could be sent out on loan in January.
Johan Djourou's agent has dismissed reports the Arsenal defender is set to join Roma in the January transfer window.
Johan Djourou believes Arsenal can achieve 'big things' with Steve Bould as Arsene Wenger's assistant manager.
Arsene Wenger says Johan Djourou is still part of his plans at Arsenal after the defender was linked with a summer move.
Johan Djourou has sought to distance himself from speculation suggesting he is contemplating a summer switch away from Arsenal.
Johan Djourou is keen to leave Arsenal for a club in Italy, according to his agent.
Watch every goal from every game in the Football League on your computer, mobile or tablet...


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Last Modified: December 3, 2002
Facing Forward Series: Life After Cancer Treatment
This NCI publication covers post-treatment issues such as follow-up medical care, physical and emotional changes, changes in social relationships, and workplace issues.
Facing Forward Series: Ways You Can Make a Difference in Cancer
This NCI publication Provides an overview of the potential benefits of involvement in activities that give back to one's community, as well as the ways in which one can become involved in these activities. Designed for cancer survivors and those who have taken care of someone with cancer.
Aug 5, 2010 - Research in hepatocelluar carcinoma, the third most common cause of cancer-related death worldwide, should be prioritized to develop new prognostic indicators and effective therapies for the disease, according to the consensus recommendations of a National Cancer Institute Clinical Trials Planning Meeting published online Aug. 2 in the Journal of Clinical Oncology.


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Yellowstone is known for its majestic vistas and stunning wildlife. One tourist, however, ended up getting a little too close and personal with some Yellowstone residents.
Have You Seen This? When the fish aren't biting, try birds
Martha Ostergar |
posted Mar 5th - 1:15pm
The right fishing conditions involve a lot of variables, and sometimes those variables align for a more-than-surprising catch at the end of your line.
Have You Seen This? Blindfolded Rubik's Cube solve
Martha Ostergar |
posted Mar 4th - 1:15pm
Speed is the name of the game in modern Rubik's Cube solving, until you add a photographic memory and a blindfold.
Have You Seen This? What we do to land internships
Martha Ostergar |
posted Mar 3rd - 1:15pm
Who would have thought a physical fight would be required to apply for an internship at an ad agency?
Have You Seen This? Why you should hire an electrician
John Clyde, KSL.com Contributor |
posted Mar 2nd - 1:15pm
Thanks to Pinterest and HGTV we all think we're expert DIY pros when it comes to our homes, but sometimes we should just put down the tools and hire a professional.
Have You Seen This? Friendly deer makes Herriman kids' acquaintance
Ben Dowsett |
posted Mar 1st - 8:55pm
A woman on her way to work in Herriman Sunday caught video footage of a friendly deer approaching and even following three kids who came up to pet it.
Have You Seen This? Drop a beat with your pen
Jarom Moore |
posted Feb 28th - 11:47am
Music comes in all forms, and when combined with boredom in school, it can make a pretty sweet sound.
Have You Seen This? Grieving mom receives emotional gift
John Clyde, KSL.com Contributor |
posted Feb 27th - 1:15pm
A grieving mom got the surprise of a lifetime and her reaction is powerful and beautiful.
Have You Seen This? Talking husky puppy
Martha Ostergar |
posted Feb 26th - 1:15pm
He might be trying to howl, but instead this husky puppy sounds like a babbling baby.
Have You Seen This? Baby is new 'Lord of the Dance'
Martha Ostergar |
posted Feb 25th - 1:15pm
A creative dad edits his daughter's play into a clever Irish dance video.
Have You Seen This? Deep thoughts with Cookie Monster
Martha Ostergar |
posted Feb 24th - 1:15pm
It's no secret that Sesame Street's Cookie Monster is obsessed with cookies, but that doesn't mean he doesn't have thoughts about other food.
Have You Seen This? A little Led Zeppelin
John Clyde, KSL.com Contributor |
posted Feb 23rd - 1:15pm
Many have tried to cover Led Zeppelin and many have failed, but a bunch of kids between the ages of 7 and 12 did a pretty solid job with three Zeppelin classics.
Secret to The Lumineers' success? A newspaper columnist
Free groceries for shoppers after cash registers crash
No booze during 'Fifty Shades of Grey' showings, Idaho says
Pair pilfer $9,000 worth of underwear from Wyoming store
Harrison Ford 'battered, but ok' after small-plane crash, son says
Firefighters rescue dog trapped in gap between walls
Faucet theft from German spy building causes water leak
Texan arrested with sword in cane, tried to visit jailed son
Feeling flush? Find bathrooms for bus drivers for $97,000
Malfunctioning Miami Beach welcome sign sends mixed message
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Game of the Week: Players change position for Wallace County
By CONOR NICHOLL
The Wallace High School football team has seven seniors. Six have played more than one season and all half-dozen have the "C" denoted for captain on the online roster.
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By CONOR NICHOLL
The Wallace High School football team has seven seniors. Six have played more than one season and all half-dozen have the "C" denoted for captain on the online roster.
However, lineman Tyrell Springsteel is the only one of those six who has never earned all-league honors. Springsteel is also the lone captain who wasn't a returning starter.
But Springsteel put in a lot of weight room work in the summer mornings and now starts at defensive end. Before the season started, coach Kevin Ayers said he expected Springsteel to make "big contributions" in 2013.
"Work your butt off," Springsteel said.
Springsteel was one of several position changes for the Wildcats, ranked No. 4 in Eight-Man, Division II in the statewide media poll, in a season-opening 51-0 victory against Dighton.
The game was called at halftime because of the 45-point mercy rule. Springsteel had just 16 tackles in his career, but collected a career-high eight last Friday.
"I know I had something to prove," Springsteel said.
Because of Springsteel starting, senior Callahan Grund -- who collected 50 tackles and 5.5 sacks, second-best on the team in 2012 -- moved out to cornerback. Springsteel also played some at nose guard to spell senior Dalton Walker and then Grund had some snaps at end.
"Still trying to find that best fit defensively, but we were very pleased with his play at defensive end," Ayers said.
The change helped Wallace County force five turnovers and finish plus-four in turnover margin, an area that Ayers stressed during fall camp. Wallace County, the classification's No. 1 scoring defense last season, held Dighton to 41 yards.
The Hornets had never scored fewer than 14 points since it ended a co-operative agreement with Ness City after the '09 season.
"He has just been a kid that has just constantly worked, constantly learned, tried to do what is right," Ayers said of Springsteel. "We have really seen him come into his own physically over this last year. A lot of this is from extremely hard work and want to get out there and contribute to our football team, and I couldn't have been more pleased on Friday night."
As well, senior Kyle Gfeller, an all-league tailback last season, started at quarterback after four-year starter Gavin Mote graduated.
"Very big role to fill," Gfeller said. "Just tried to do my best."
Gfeller had completed 12 of 23 passes for 178 yards with a 3/0 TD/INT ratio before last Friday, but called the start "very nerve-wracking," because he hadn't taken many snaps.
He completed 2 of 4 passes for 22 yards with a TD and rushed 10 times for 56 yards and two scores.
"He had an extremely good summer," Ayers said. "I thought he ran the offense well."
"Have to be smart," Gfeller added.
Defensively, Gfeller picked off two passes and now has six in his career, at safety.
"Some of them came from a little pressure on the quarterback, which also helps, so you have got to give the D-line some credit," Ayers said. "But Kyle was also right place, right time, getting back there, being a quarterback, being in the right drop, in the right place, and he did a nice job of that."
Wallace County also picked up three fumbles. Gfeller said the team was "more aggressive."
In 2007, the Wildcats went 13-0 and forced 37 turnovers en route to the Eight-Man Division II state championship.
Since then, Wallace County has forced 16, 24, 15, 22, and 21 turnovers the last five years, an average of 1.92 turnovers per game. From 2009-12, the Wildcats finished plus-12, minus-5, plus-9, and plus-6 in turnover margin.
Ayers talked about turnovers throughout camp. The point was solidified further when Ayers watched the NFL during the weekend and he saw a stat that said turnover margin is the No. 1 statistic in determining wins and losses.
"It's definitely been a focal point," Ayers said. "I would say we are stressing it a little bit more. We have always really stressed it, but we have just ramped it up. It's something that has definitely hurt us in the past, and it's something that we want to take care of and definitely win that battle every Friday night."


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Shark Patchwork Plush
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We made these sharp-teethed sharks super squeezable for summer cuddles. Their colorful bodies and fins are sewn from a playful patchwork of fabrics.
- Shark: 36" long x 9.5" wide x 9" high
- Hammerhead Shark: 19.5" long x 8.5" wide x 4" high
- Sewn with a variety of cotton prints for a handcrafted look.
- Polyester fill.
- Ages 3 and up.
- Imported.
- Dimensions & Care
- Spot clean.
- Surface is washable with warm water and mild soap.
- Shipping Info
- Please allow 5-7 business days for delivery. Delivery estimate includes monogrammed and gift-wrapped items.


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Augusta City Directories Catalog
The Augusta-Richmond County Public Library is proud to announce the publication of the Catalog of the Augusta (Georgia) City Directories, 1841-1939. This 61-page book describes each volume in detail, enumerating the type of information a researcher can find in every year in which a directory was published. One can immediately determine when names of spouses are provided (by race), when local officials and employees are listed, what years street cross- references are available, plus a wealth of other information, including statistics, brief histories of the local area, and photographs of Augusta. This finding aid to the microfilmed directories makes searching them much easier, plus introduces the researcher to the wealth of information to be found in this often-ignored source. The Catalog is fully indexed, and includes a guide to the contents of the microfilm reels themselves.
Also Available from the Augusta-Richmond County Public Library
PERSONAL NAME INDEX TO THE AUGUSTA CHRONICLE (AUGUSTA, GEORGIA) This four-volume set of hard-bound books covers names of individuals who lived in East-Central Georgia and the surrounding areas of South Carolina, from 1786-1830. Citations include full name, name of spouse (where shown), type of event, and a complete reference to the newspaper. Types of events indexed range from death and marriage notices to probate announcements, grand jury presentments, business advertisements, legislative action and news stories.Reviewer Comments on the Personal Name Index to the Augusta Chronicle
"This reviewer always looks forward to the appearance of another volume in this outstanding series."
- Raymond A. Winslow, Jr., The North Carolina Genealogical Society Journal
"...one of the most important such complilations for Southern genealogy that will be of great help to families living throughout the United States who have pioneering ancestors in the area of South Carolina and Georgia..."
- LaViece Smallwood, The Florida Times Union(Jacksonville)
Book prices:
Copies of the Catalog of the Augusta City Directories, $10.00
Copies of Vol. I (1786-1799) Personal Name Index, $27.50
Copies of Vol. II (1800-1810) Personal Name Index, $27.50
Copies of Vol.III (1811-1820) Personal Name Index, $27.50
Copies of Vol. IV (1821-1830) Personal Name Index, $27.50
Registers of Signatures of Depositors
in the Augusta, Georgia, Branch Of the Freedman's Saving and Trust Company
Volume I, November 1872-June 1872
Finally! A source for African-American Genealogical Research In Georgia & South Carolina.
The Augusta-Richmond County Public Library is proud to announce the publication of the first volume of Registers of Signatures of Depositors in the Augusta, Georgia, Branch of the Freedman's Saving and Trust Company, by Alice O. Walker. This book serves as a springboard for researchers studying African-American genealogy in the Augusta (GA)-Aiken (SC) area. Since the records begin in November 1870, they provide a critical link with the 1870 Federal population schedules. The Registers contain the following information on each applicant: name; date of application; place of birth; place brought up; residence; age; complexion; spouse; children; parents; siblings, and remarks. The remarks section typically includes the names of grandparents, aunts and uncles. This first volume covers half the existing records: November 1870 through June 1872. It is hardbound and contains over 700 pages, with a complete index, and an introduction, which includes a brief history of the bank as well as notes on the local records. In addition, 360 endnotes are included, providing cross-references to the 1872 Augusta City Directory, historical references, and corrections or additions to the original document.
Copies @ $35.00 each (plus $2. 50 shipping & handling)
Publication of this book was made possible by a grant from the R.J. Taylor, JR. Foundation.
Augusta- Aiken Clubs and Organization List
A comprehensive list of non-profit clubs and organizations of the Augusta-Aiken area is published annually by the staff of the library. The list provides the following information: organization's name, location, phone number, fax number, e-mail address, and point of contact.
Copies@ $5.00 each (plus $2.00 shipping & handling)
Order from:
Augusta Public Library
823 Telfair Street
Augusta, GA 30901-2294
(706) 821-2600
Send to the attention of the Information Department. Make checks payable to the Augusta-Richmond County Public Library


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University of Pennsylvania Cancer Center
Ultima Vez Modificado: 16 de mayo del 1999
A team of investigators from the M.D. Anderson Cancer Center, led by Dr. Christopher Logothetis, has demonstrated evidence that replacement of the p53 gene may shrink prostate cancers.
The function of the p53 gene, which induces damaged cells to activate "programmed cell death," is lost as cancer progresses and spreads. Therefore, replacing p53 to increase production of its normal protein, which would lead to cancer cell death, could reduce the size of prostate tumors, said Logothetis, who added that this strategy has been shown to be feasible in other cancer types, such as lung and head and neck cancer.
The gene was delivered by injection into the prostate, and the patients had a prostatectomy (removal of the prostate gland) performed following therapy. The investigators were able to demonstrate on serial examination before the prostatectomy that seven of the 26 treated cancers reduced in size. A total of 30 patients are being treated but some have not completed the therapy schedule. Logothetis and his research colleagues view the results of the study as encouraging evidence in support of the original hypothesis, and says it will serve as the foundation for combination therapy incorporating p53 gene therapy in the treatment of prostate cancer.
Aug 31, 2010 - Researchers have discovered a mechanism by which adenoviruses breach cellular defenses, and this could help explain how p53 tumor-suppressor genes are disabled in cancer cells and point the way to the development of new, more effective targeted cancer therapies; these findings have been published in the Aug. 26 issue of Nature.


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Aug, 2013
Language and Library Trends (Continued) This blog is a continuation of a series of blogs that present the highlights from the 2012 Wilson Research Group Functional Verification Study (for a background on the study, click here). In my previous blog (Part 8 click here), I focused on design and verification language trends, as identified by the Wilson Research Group study. This blog presents additional … Read More
SVA, UVM, Accellera, Assertion-Based Verification, Verification Methodology, OVL, PSL, Functional Verification


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The EphrinB2/EphB4 axis in regulating hESC pluripotency and differentiation
The EphrinB2/EphB4 axis in regulating hESC pluripotency and differentiation
Funding Type:
Basic Biology II
Grant Number:
Award Value:
Stem Cell Use:
Embryonic Stem Cell
Public Abstract:
Human embryonic stem cells (hESC) have an inexhaustible ability to divide and renew, and under the appropriate conditions, differentiate and change into any cell type in the body. This balance between pluripotency and self-renewal is a complex and carefully choreographed response of the hESC to local microenvironmental cues. Understanding the molecular regulators of this balance, and the various signals that are integrated by hESC to maintain their pluripotency and self-renewal characteristics are critical for the expansion and differentiation of hESC to specific cell types, which is the ultimate goal of regenerative medicine.
EphrinB2 and ephB4 belong to a large family of cell surface signaling molecules, so called receptor tyrosine kinases (RTKs), that mediate and transduce signaling cascades upon interaction with each other. Cell-cell contacts between ephrinB2 and ephB4 expressing cells provide guidance cues for cell migration and boundary formation in many developmental systems such as the formation of neurons and blood vessels. Importantly, ephrinB2 has been determined to be a molecular marker of "stemness" and is expressed in human embryonic stem cells, neural stem cells and hematopoietic stem cells. Its cognate receptor, EphB4, has also been shown to affect mouse ESC fate. Despite much evidence from model systems that ephrinB2/ephB4 axis may be intimately involved in ESC fate (survival, self-renewal, and pluripotency), this particular axis has not been carefully studied in human ESC.
EphrinB-ephB ligand-receptor interactions are promiscuous, and the lack of highly specific reagents to block cognate ephrinB2-ephB4 interactions has hampered studies into the role of this RTK axis in regulating hESC survival, pluripotency and differentiation. Intriguingly, the envelope protein from an exotic and highly lethal virus called Nipah virus, binds to ephrinB2 with high specificity. Using an arsenal of reagents based on engineered versions of this viral envelope protein, which retains the ephrinB2 binding properties without the virulence of the actual virus, we will interrogate the ephrinB2-ephB4 axis in regulating hESC fate. Extant data from murine ESC suggest that EphB4 activation (signaling) not only favors mesodermal differentiation (a germlayer that gives rise to blood cells, endothelial cells, and muscle cells), but that EphB4 inactivation may result in expansion of primitive hematopoietic (blood) stem cells (HSC) while maintaining their "stemness". Understanding the regulation of this signaling axis could improve the culture of hESCs and the efficiency of HSC lineage differentiation, both key barriers in the field.
Statement of Benefit to California:
Human embryonic stem cells (hESC) have the potential to be a game changer in the practice of medicine. This is due to their apparent inexhaustible ability to divide and renew, and under the appropriate conditions, differentiate and change into any cell type in the body. In theory, scientists could differentiate hESC into any desired cell type in the test tube and use them to replace the desired cell type that is defective or wanting in the patient. This is the promise of regenerative medicine. However, the translation of this technology to actual patient use depends on a better understanding of how pluripotency (the ability to develop into any cell type) is maintained, and the specific conditions under which a particular cell type can be differentiated. This proposal will benefit California by seeking a better understanding of these processes, which will bring us closer to realizing the dream of regenerative medicine, and fulfilling the intent of Proposition 71.
Our proposal seeks to understand how a particular set of cell surface signaling molecules interact, and how these interactions lead to the maintenance of pluripotency or how they may skew hESC towards differentiation to a specific cell lineage. These cell surface signaling molecules are called ephrinB2 and ephB4, and their cognate interactions are known to trigger a cascade of intracellular signals that then determine the fate of hESC. Despite tantalizing evidence from animal model systems that the ephrinB2/ephB4 axis is important for many aspects of ESC fate, it has been difficult to interrogate this axis in human ESC biology due to the lack of highly specific reagents that can block this axis. This proposal capitalizes on a tool that Nature has "unwittingly" provided from an unexpected source. The viral envelope protein from an exotic virus (called Nipah virus) can bind to ephrinB2 with extraordinarily high specificity and block its interaction with ephB4. Using an arsenal of reagents based on this viral envelope protein, we will properly interrogate the role of the ephrinB2/ephB4 axis in hESC fate and development. Understanding the regulation of this signaling axis could improve the culture, expansion, and efficiency of lineage differentiation of hESCs, all key barriers in the field.
Progress Report:


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Drug Notes
UPMC Patient Education Materials
Calculators and Assessment Tools
Anatomy Navigator
Conditions Navigator
Reflux nephropathy is a condition in which the kidneys are damaged by the backward flow of urine into the kidney.
Chronic atrophic pyelonephritis; Vesicoureteric reflux; Nephropathy - reflux; Ureteral reflux
Urine flows from each kidney through tubes called ureters and into the bladder. When the bladder is full, it squeezes and sends the urine out through the urethra. None of the urine should flow back into the ureter when the bladder is squeezing. Each ureter has a one-way valve where it enters the bladder that prevents urine from flowing back up the ureter.
But in some people, urine flows back up to the kidney. This is called vesicoureteral reflux.
Over time, the kidneys may be damaged or scarred by this reflux. This is called reflux nephropathy
Reflux can occur in people whose ureters do not attach properly to the bladder or whose valves do not work well. Children may be born with this problem or may have other birth defects of the urinary system that cause reflux nephropathy.
Reflux nephropathy can occur with other conditions that lead to a blockage of urine flow, including:
Reflux nephropathy also can occur from swelling of the ureters after a kidney transplant or from injury to the ureter.
Risk factors for reflux nephropathy include:
Some people have no symptoms of reflux nephropathy. The problem may be found when kidney tests are done for other reasons.
If symptoms do occur, they might be similar to those of:
Reflux nephropathy is often found when a child is checked for repeated bladder infections. If vesicoureteral reflux is discovered, the child's siblings may also be checked, because reflux can run in families.
The blood pressure may be high, and there may be signs and symptoms of chronic kidney disease.
Blood and urine tests will be done, and may include:
Imaging tests that may be done include:
Vesicoureteral reflux is separated into five different grades. Simple or mild reflux often falls into grade I or II. The severity of the reflux and amount of damage to the kidney help determine treatment.
Simple, uncomplicated vesicoureteral reflux (called primary reflux) can be treated with:
Controlling blood pressure is the most important way to slow kidney damage. The health care provider may prescribe medicines to control high blood pressure. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are often used.
Surgery is usually only used in children who have not responded to medical therapy.
More severe vesicoureteral reflux may need surgery, especially in children who do not respond to medical therapy. Surgery to place the ureter back into the bladder (ureteral reimplantation) can stop reflux nephropathy in some cases.
More severe reflux may need reconstructive surgery. This type of surgery may reduce the number and severity of urinary tract infections.
If needed, patients will be treated for chronic kidney disease.
The outcome varies, depending on the severity of the reflux. Some people with reflux nephropathy will not lose kidney function over time, even though their kidneys are damaged. However, kidney damage may be permanent. If only one kidney is involved, the other kidney should keep working normally.
Reflux nephropathy may cause kidney failure in both children and adults.
Call your health care provider if you:
Quickly treating conditions that cause reflux of urine into the kidney may prevent reflux nephropathy.
Tolkoff-Rubin NE, Cotran RS, Rubin RH. Urinary tract infection, pyelonephritis, and reflux nephropathy. In: Brenner BM, ed. Brenner and Rector's The Kidney. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 34.
Zeidel ML. Obstructive uropathy. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 124.
Charles Silberberg, DO, Private Practice specializing in Nephrology, Affiliated with New York Medical College, Division of Nephrology, Valhalla, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.
For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.
UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, gender identity, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.
Medical information made available on UPMC.com is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, UPMC.com is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.
For UPMC Mercy Patients: As a Catholic hospital, UPMC Mercy abides by the Ethical and Religious Directives for Catholic Health Care Services, as determined by the United States Conference of Catholic Bishops. As such, UPMC Mercy neither endorses nor provides medical practices and/or procedures that contradict the moral teachings of the Roman Catholic Church.
© UPMC Pittsburgh, PA, USA UPMC.com


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Franco De Grandis was born in Turin and studied voice and piano at the city Conservatory. In 1981, he won the As.li.co. Competition. He went on to enter the Maria Callas Competition in Rome in 1983, which was also the year of his debut at Milan's Teatro alla Scala in Turandot (Timur), conducted by Lorin Maazel. This marked the beginning of an international career that would bring him to work with major orchestra conductors and at the most prestigious opera houses. After performing in Salzburg in 1985 in the production of Don Carlos, directed by Herbert von Karajan, and then in Tosca the following year, De Grandis was invited to La Scala in Milan, where he appeared in the production of Guglielmo Tell conducted by Riccardo Muti. He debuted at the New York Metropolitan Opera House in Il Trovatore alongside Luciano Pavarotti, conducted by Richard Bonynge, and performed at the Vienna Staatsoper, the Grand Théâtre in Geneva and the Municipal Theatre in Florence. His repertoire includes a wide variety of roles, such as Sparafucile in Rigoletto, Ramfis in Aida, Colline in La Bohème, and Basilio in Il Barbiere di Siviglia. He has also appeared in Don Carlos, Luisa Miller, Simon Boccanegra, Macbeth, Samson et Dalila and Spontini's Vestale. His concert repertoire includes Verdi's Requiem and Mozart's Requiem. In the 1996/97 season he appeared as Sparafucile in Rigoletto in Venice, at the Théâtre du Capitole in Toulouse and at the Arena di Verona (where he also played Ramfis in Aida). He played Banquo in Macbeth at the Municipal Theatre in Treviso and at the Municipal Theatre in Rovigo, and Fiesco in Simon Boccanegra at the Theatre in Messina. In Santiago, Chile, he was a soloist in Verdi's Requiem.
For the 1997/98 season, he appeared in Massenet's Roméo et Juliette at the Washington Opera, and in Rigoletto at the Bellini Theatre in Catania, debuting in the role of Oroveso in Norma, performed in Messina. Every year, he has also played the role of Ramfis in Aida at the Arena di Verona. In 1999 he played Sparafucile at the Opéra in Nice. In 2000 De Grandis debuted in Stravinskij's The Rake's progress at the Bellini Theatre in Catania and was a soloist in the Bologna performance of Verdi's Requiem, also participating in the tour of the Arena di Verona Opera Company in China. In 2001 he played Zaccaria in Nabucco, Ferrando in Il Trovatore and Banquo in Macbeth, performing in Dresden, Copenhagen and Messina. He subsequently appeared in La Forza del destino, Don Giovanni, Guglielmo Tell, Mephistofele and Boris Godunov. In 2003 De Grandis played the role of Ferrando in Il Trovatore at the Opera House in Cagliari, and in 2004 he was Sparafucile in Rigoletto at the Arena di Verona. July 2004


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In 1999, Google was barely a blip on the business radar. In 2005, YouTube had yet to distribute its first video, and Facebook was just taking off with only 5.5 million users. But look no further than the mobile device to which you are always tethered and those ubiquitous WiFi signals to find that emerging media today impact every corner of our lives.
Emerging media is the evolving use of technology and digital content to enhance work, play, and learning, to broaden access to information, and to enrich personal connection by eliminating the constraints of time and location.
Ball State's Emerging Media Initiative (EMI) is a more than $20 million investment in focusing the university's historic strengths in this area, accelerating benefits to the state of Indiana with media-savvy human capital. Our students have access to innovative and entrepreneurial opportunities in emerging media across the curriculum. Our growing emphasis on new ideas, technology transfer, and commercialization provide the support faculty need to bring their ideas to market.
The initiative, funded through combined institutional and new private resources, has four components: leadership and sustainability, faculty and research, student opportunities, and engagement and economic development. Learn more about our vision and our successes.


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Versatile Nutmeg: 30 Sweet and Savory Recipes
Best known for its use in pumpkin pies and cakes, nutmeg's versatile flavor can be used to enhance both sweet and savory dishes.
Did the mention of pumpkin pie catch your attention? Indulge in these incredible pumpkins pies.
Apple and Oat Scones with Cinnamon and Nutmeg
These scones are light yet hearty and the most healthful of the bunch. Fresh apple keeps them moist, buttermilk contributes tenderness, and oats add a pleasantly toothsome texture.
Recipe: Apple and Oat Scones with Cinnamon and Nutmeg


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Roll Over Image to Zoom
Doll "My First" Stroller
- Overview
Take favorite dolls out for a walk or a jog with this sporty stroller. Designed to resemble the real thing, it features seat straps, a sun hood and a storage shelf below.
- 13" wide x 23" deep x 22" high
- Fits up to 17" dolls.
- Built with a metal frame, plastic and durable polyester fabric.
- Indoor-safe molded wheels.
- Ages 3 and up.
- Assembly required.
- WARNING: CHOKING HAZARD – Click for details.
- Imported.
- Dimensions & Care
- Spot clean with a damp, white cloth.
- Shipping Info
- Please allow 5-7 business days for delivery. Delivery estimate includes monogrammed and gift-wrapped items.


text: Got a call from loveland on the 23rd letting us know that they would be opening on sunday the 24th. I was quick to wax the board grab some beers and wait a sleep-less night in anticipation for the shred on sunday! I meet up with Gags,Chach,Lips,Decicco,Jake Steez, Sasso. We all jumped right in and started the get our turns on! It was great opening day, the temp was a bit cold but the side country and ribbon of fun were killer!


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Guiri Guide is looking for a couple adventurous and enthusiastic expats in Madrid who also happen to have the propensity to write and share.
Our Guiri Guide writers have a thirst for experience and a positive attitude when it comes to their encounters. Moving to a foreign country is never without its dramas but with our Guiri community of support, it can be enjoyable. A true Guiri Guide writer lays out the "Welcome" mat for new expats and then continues as the neighborly host through and through. Do you have what it takes!?
Contact us to learn more or to ask questions at email@example.com


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Drug Notes
UPMC Patient Education Materials
Calculators and Assessment Tools
Anatomy Navigator
Conditions Navigator
Asthma is a disease that causes the airways of the lungs to swell and narrow, leading to wheezing, shortness of breath, chest tightness, and coughing.
Bronchial asthma
Asthma is caused by inflammation (swelling) in the airways. When an asthma attack occurs, the lining of the air passages swells and the muscles surrounding the airways become tight. This reduces the amount of air that can pass through the airway.
In persons who have sensitive airways, asthma symptoms can be triggered by breathing in substances called allergens or triggers.
Common asthma triggers include:
Many people with asthma have a personal or family history of allergies , such as hay fever (allergic rhinitis) or eczema . Others have no history of allergies.
Most people with asthma have attacks separated by symptom-free periods. Some people have long-term shortness of breath with episodes of increased shortness of breath. Either wheezing or a cough may be the main symptom.
Asthma attacks can last for minutes to days, and can become dangerous if the airflow is severely blocked.
Symptoms include:
Emergency symptoms that need prompt medical help:
Other symptoms that may occur:
The doctor or nurse will use a stethoscope to listen to your lungs. Wheezing or other asthma-related sounds may be heard.
Tests that may be ordered include:
The goals of treatment are:
You and your doctor should work as a team to manage your asthma. Follow your doctor's instructions on taking medicines, eliminating asthma triggers, and monitoring symptoms.
There are two kinds of medicines for treating asthma:
Long-term Medicines
These are also called maintenance or control medicines. They are used to prevent symptoms in people with moderate to severe asthma. You must take them every day for them to work. Take them even when you feel OK.
Some long-term medicines are breathed in (inhaled), such as steroids and long-acting beta-agonists. Others are taken by mouth (orally). Your doctor will prescribe the right medicine for you.
Quick-relief Medicines
These are also called rescue medicines. They are taken:
Tell your doctor if you are using quick-relief medicines twice a week or more. Your asthma may not be under control and your doctor may need to change your dose of daily control drugs.
Quick-relief medicines include:
A severe asthma attack requires a checkup by a doctor. You may also need a hospital stay. There, you will likely be given oxygen, breathing assistance, and medications given through a vein (IV).
Asthma action plans are written documents for managing asthma. An asthma action plan should include:
A peak flow meter is a simple device to measure how quickly you can move air out of your lungs.
There is no cure for asthma, although symptoms sometimes improve over time. With proper self-management and medical treatment, most people with asthma can lead normal lives.
The complications of asthma can be severe, and may include:
Call for an appointment with your health care provider if asthma symptoms develop.
Call your health care provider or go to the emergency room if:
Go to the emergency room if these symptoms occur:
You can reduce asthma symptoms by avoiding triggers and substances that irritate the airways.
Brozek JL, Bousquet J, Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol. 2010;126:466-76.
Lugogo N, Que LG, Fertel D, Kraft M. Asthma. In: Mason RJ, Broaddus VC, Martin TR, et al., eds. Murray & Nadel's Textbook of Respiratory Medicine. 5th ed. Philadelphia, PA: Elsevier Saunders; 2010:chap 38.
National Asthma Education and Prevention Program Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Rockville, MD. National Heart, Lung, and Blood Institute, US Dept of Health and Human Services; 2007. NIH publication 08-4051. Available at http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.htm. Accessed May 14, 2014.
Nowak RM, Tokarski GF. Asthma. In: Marx JA, Hockberger RS, Walls RM, et al., eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 7th ed. Philadelphia, PA: Elsevier Mosby; 2009:chap 71.
Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.
UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, gender identity, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.
Medical information made available on UPMC.com is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, UPMC.com is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.
For UPMC Mercy Patients: As a Catholic hospital, UPMC Mercy abides by the Ethical and Religious Directives for Catholic Health Care Services, as determined by the United States Conference of Catholic Bishops. As such, UPMC Mercy neither endorses nor provides medical practices and/or procedures that contradict the moral teachings of the Roman Catholic Church.
© UPMC Pittsburgh, PA, USA UPMC.com


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quote:I'm never switching from extract
quote:There is a definite bourbon presence to the taste, but it is very smooth. The oak does a good job of mellowing it out and gives it hints of vanilla. Then the imperial stout comes through with some sweetness and maltiness.
quote:Yeah, I'm all about the all-grain these days. I've had varying success with mash efficiency and stuck sparges. My first attempt at all-grain was actually the most efficient, close to 80%, which probably meant my strike water was a little too cool. No off flavors though that I could pick up.
quote:I'm talking about mashing in by adding my grains to my cooler full of water. Then sparge with another 4 gallons after I've drained my initial mash water.
quote:ounds pretty good to me. Drink them up in this weather.
quote:Well like i've said, everything i've read says to always add the water to the grains, never grains to water. I believe i read it in how to brew and also in brew your own magazine. But also, Frat is the home brew buddha on this board, so i wouldn't question him if he says it's fine. I've only done 3 all grain brews, so i too, am still learning my way around it.
quote:3. Pour in about 1 gallon of your strike water into the Mash Tun and stir in the crushed grain. This is the doughing-in stage. Mix the water and grist together gradually to avoid shocking the enzymes. Stir it to make sure all the grain is fully wetted,
quote:So you should add a gallon to the mash tun, and then add the grain to get it started... then slowly add the rest of the strike water?
quote:There are apparently many ways to skin a cat.
quote:I add my water to the mash tun a little warm to account for the mash tun taking some of the heat.
quote:I typically boil water and throw it in the mash tun about 15 minutes before adding my grain to let the tun heat up.
quote:I did that too and the inside of the cooler warped a little. I was like WTF?
quote:What kind of cooler do you use?
quote:What are the advantages of boiling the wort 90 minutes, as opposed to 60 minutes?


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Do any of you guys have Time Warner cable? So I've had them for a couple of years here in Cincinnati when suddenly my service was cut. I always pay the bill on time, so I called them. Apparently an audit shows that someone at my address from years ago left without paying a bill (an apartment). Due to something they call a "roommate policy", they cut me off. They won't allow me to get service until I pay $460 that someone I've never even met owes them, just because we shared an address. Worst part, I have no choice...they're the only provider in my area for internet AND TV. No TV or internet for over a month now.
Excuse the typos...typing on a phone sucks.


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Tall Leopard Print Collar Wool Blend Twill Pea Coat
Tall Leopard Print Collar Wool Blend Twill Pea Coat
$129 .88
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 Done in a luxe wool blend - and finished with a fantastically fuzzy leopard print collar - this wildly cute coat is one piece your cool weather wardrobe can't live without. Removable collar. Covered button front. Long sleeves. Front patch pockets. Back buttoned waist tab. Lined. 33" long.
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47% Polyester, 46% Wool, 5% Acrylic, 2% Other
Dry Clean Only


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Reno´s insight view about Red Bull King of the Air!
Oozing style both on and off the water, Reno Romeu is North Kiteboarding's Brazilian smooth operator. Residing in Rio De Janeiro he first started kiteboarding in 2002, progressing at lightning speed hitting the PKRA tour a few years later. Having cruised through the heats in last years event, he was invited to participate in the Red Bull King of the Air in Cape Town, South Africa for a second year running. Always looking to improve his performance on the water and push the boundaries of the sport we caught up Reno after the event.
How is it coming from the PKRA into a competition like the Red Bull King of the Air?
It's truly great! All year I'm travelling on the PKRA tour and there is a lot of pressure that comes with it. It's refreshing to participate in an event where I feel so relaxed. The Red Bull King of the air is one of the best events around with such a great atmosphere, hype and extreme conditions. It's great fun and I get a lot of enjoyment out of doing it with friends and other riders.
Do you rate this style of riding even though you are more technical?
I would say that the this event requires technical riding, just in another way. The PKRA requires a certain style and the tricks are very technical so you really have to be focused for the duration of the event, even when you are not in the water. The Red Bull King of the Air is more like a momentum. It is a competition but, you are just trying to go bigger then the other riders on the water. With all the adrenaline pumping through your body your mind set is different, it's almost like you go a little crazy. You just have to go for it!
You chose to ride in boots for the competition. Why is that?
I actually tried riding straps in the first heat as I was afraid of hurting myself and compromising my year ahead on the PKRA, but it was awful. After only using boots for a longtime now I couldn't ride as I wanted. I still made it through the heat but as soon as I got out of the water I put the straps to one side and grabbed my boots. In this event, you go big or you go home. There's no doubt that with boots I have more control of the board, can ride faster, land harder and hold more pressure from the kite. All important factors for the King of the Air.
What was your set up for the event?
I rode the 10 meter and 8 meter Vegas with the back lines on the 'wakestyle' setting. My bar had 22m lines which was great for high jumps and aggressive kiteloops and I rode the 137cm Team Series with the NKB Banana Boots, of course.
How does this 'hangtime' set up differ from your usual wakestyle set up?
I didn't actually change anything. I love to go big anyway, so often after a training session I go for a freeride and catch some big airs. The Vegas is a great kite for both styles, the key for this event is to take a bigger kite then normal and hit the water totally overpowered.
How do you prepare for an event such as this?
Drink a Red Bull. It gives you wings!
Do you think we will see a return of the 'old school' riding as there has been so much emphasis on 'wakestyle' over the past years?
I don't think so. In my opinion, every activity you do, you look to improve the technical difficulty of it. It's the natural progression of sport and I don't see big air doing this. Big air is a show and I don't think it can become something like a World Tour as its not really that technical or difficult, it's extreme!


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Tag "wie"
Virgo ~ The Goddess Is In The Details
By Caroline
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Welcome to the month of Virgo, a powerful month in which we have the opportunity for solitude and soul-searching. It's the time when we can take a critical eye to the details of our lives and make changes for the better. If you are in need of some time to clean out your emotional closet, this is your month!


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Zesty and sweet...a perfect combination
Er'go presents their Spectrum Collection, which includes full range of fragrance styles that contain both obvious and subtle tones. The fragrance blends are composed of an average of thirty oils - only the top two to three oils are listed.
Mandarin Vanilla scented candle includes notes of Mandarin, Vanilla, and Nutmeg
Price: $20.00


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Start learning with our library of video tutorials taught by experts. Get started
Explore the basics of Flickr, from posting, organizing, and editing photos to participating in the Flickr community.
"lynda.com has enabled me to grow my skill set at an affordable price. I find the business profiles/documentaries inspiring and the training is top notch." —Shawn C.
more from our members »


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Marisa Straight Leg Pants in Fluid Stretch Twill
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Ava Espresso Counter Height Set - 5 pc..
(Click to learn about White Glove Delivery.)
Attractive as well as functional, the Ava five-piece counter height dining set pulls from casual influences to create a simple yet elegant piece of furniture for today's lifestyle. Constructed of 100% solid wood, the Ava dining set is designed to be in your home for years to come. The counter height table features a 12" leaf, multi step espresso finish, and seats four comfortably. The counter chairs are perfectly scaled and also feature the multi-step espresso finish. Also, complete the room with the Ava Server (sold separately). This five-pc. set includes a counter height table and four counter height chairs. Minor assembly required.
For questions or concerns regarding this product, please contact the Manufacturer's Customer Service Department at email@example.com.
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Veterans Day has us thinking about the incredible sacrifice of everyone who has served in the military, both past and present. In this issue of TakePart on MSN Causes, we bring attention to the ways in which our service people inspire us and how we can do our part to support them.
"Simple: I serve for the love of our country," said Scott Henry, Master Sergeant in the D.C. Air National Guard, when we asked him why he risked everything to join the military. Our gallery "Why I Served" brings together stunning photographs and the inspiring answers to this question from veterans around the country.
As for troops on the ground today, ever since the nonprofit Troops Direct learned of a battalion marking roadside bombs with bottle caps and Q-tips, the organization has been sending about 1,000 pounds of chalk each month to Afghanistan along with tons of other essentials. Find out what the top 10 items requested from the field are. You won't believe it—and you can help.
Plus, we have an interview with Nashville's Connie Britton, a story on "7 Surprising Treatments for PTSD," a compelling interview with the Chairman of the House Committee on Veterans' Affairs, meaningful actions you can take to help veterans, and more.
Enjoy our stories, share them, and take a minute with us to hope for peace.


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Over the past two years, architect Robert Mills (Robert Mills Architects and Interior Designers) and his yoga-enthusiast spouse, Lucinda Mills, have created a sophisticated yoga and Pilates emporium in Melbourne's South Yarra neighbourhood.
The business, One Hot Yoga, is divided into four studios that occupy space at three addresses. Studio 1 (One Hot Yoga) is at 36 River Street, Studio 2 (One Hot Yoga and Mat Pilates) is at 46 River Street, and right next door at 48 River Street is the newest addition, Studios 3 and 4 (One Hot Pilates).
In total, the studios take up nearly 800 square meters (about 8600 square feet) of space. We love the reception area with its minimalist customized furnishings, glass-covered display case and views of the inner courtyard with its lush greenery.
Simplicity, natural materials, finely controlled lighting and tone-on-tone colour schemes create a gracious and calm environment for all of the spaces. Elegant touches, such as heavy linen curtains and beautiful change rooms enhance the ambiance of understated luxury. Tuija Seipell
A science and engineering museum's café project inspired interior designer and photographer Anna Wigandt to create a cool space for enjoyment and study, but she also invented a few products of her own.
The Science Cafe & Library is located in Wigandt's home town, Chişinău (formerly known as Kishinev), the capital city of Moldova on the river Bîc.
The main features of the self-serve café and library are the jigsaw-puzzle table and the book displays.
The table's inspiration, according to Wigandt, was German astronomer Johannes Kepler's 1596 book, Mysterium Cosmographicum (Cosmic Mystery) that dealt with the proportions of celestial bodies.
The modular table's various configurations allow set-ups from small: each café visitor can form their own work table, to large: lecture groups to gather around one big table.
The surrounding book displays are divided into eight topic areas ranging from Shipbuilding and Astronautics to Nuclear Science and Biological Engineering, each identified with the striking lettering.
The greatest achievement in this project, however, is the lighting. The designer ended up inventing a few engineering marvels of her own in the process. The chandelier was created specifically for the space out of 408 actual test-tubes. The same tubes were used for the pendants hanging from the meatal rigging above the table.
The celestial darkness of ceiling give the entire space an aura of being outdoors, under midnight sky. We also like the hexagons, chevrons and honeycomb patterns on the walls and floor. - Tuija Seipell.
Many of the trends we are seeing – and liking - in retail, hospitality, services and even urban planning, deal with smaller size because a strong, growing segment of us is tired of Big.
We want small, independent, pop-up, mobile, local, rogue. But – and this is an important but – we want it served up to us in a professional manner, we do not want amateur fumbling even from the smallest providers.
In essence, we want what we cannot have from the mega-malls, big boxes, airports, big brands or grocery giants. And that leads to another important 'but'. We want small BUT we still want the big, too. Nothing new here, but it still seems that many brands, marketers and researchers have a hard time dealing with the fact that we are not black-and-white, either-or. We are both-and, plus a little extra.
You cannot divide consumer habits into age categories or behaviours the way you could a decade or two ago. We are indeed picking and choosing from each basket, and we will continue to do so, but we are choosing small significantly more often than we used to.
It is hard to imagine someone whose ideal living environment - city, town or village – would be a vast expanse of gigantic malls where global brands offer indistinguishable wares in boring lookalike stores, or where cavernous big boxes ply cheap goods stacked up floor to ceiling. Acres of parking lots; people always in cars. And actual "living" taking place separately in isolated enclaves, and working in yet another isolated location.
More and more frequently, we envision the ideal living environment as something quite similar to a traditional small town or vibrant village. Or a neighbourhood with people, services and work all within walking or biking distance.
We believe that this trend is going to get stronger and stronger, and it will be good for the businesses that understand their niche and offer their customers true value: something that is worth their money and time.
Small businesses are the essence of such neighbourhoods and towns. They are the glue that makes it all stick together. They bring people together, they create small oasis of lovely interaction.
But just like in the traditional small town, today's small businesses must try harder. From the startup on, they must earn their place in the circle. The merchants and service providers in the old towns were professionals of their trade. They knew their customers, they respected them and they worked hard at earning their trust. The same is true today.
This trend, as we said earlier, is nothing new. It has been brewing for a long time in step with our overall dissatisfaction with the big, faceless brands and their outsourced, hopelessly horrible "service." When Seth Godin wrote about the topic in 2005, we all took notice. Yet today, almost a decade later, it is still only a trend. But we believe it's time has finally come.
Big brands offer smaller
One aspect of this trend is seen in the behavior of many big brands that are opening smaller-scale stores, restaurants and hotels that are more intimate, offer a more tightly edited selection of products and services, are targeted and tailored to meet individual local markets, and usually also pay more attention to design and local tastes.
Boutique-scale businesses
We are also seeing a renaissance of boutique-scale businesses; stores, hotels, restaurants and services that do not plan to grow bigger, only better. These are often one-store or one-hotel operations that gain a dedicated, loyal client base by understanding their customers better than their bigger competitor chains.
Unfortunately, many of these become so successful that the bigger competitors want to buy them out in order to either remove them from the market or to gain some of their halo. Usually, with such buy-outs, the aura of the independent, owner-operated business disappears and the previously so loyal clientele moves on. The heart is gone from the business and the clients can see it.
Of course, another much-talked-about aspect of this trend are pop-ups. Any brand worth their reputation has opened pop-ups by now, but it is still an appealing proposition for both brands and customers. Pop-ups liven up neighbourhoods, malls and streets with new, temporary offerings. They give big and small businesses an opportunity to test markets, products and services. They give businesses a chance to benefit from temporarily empty spaces. And they liven up potentially dead storefronts.
Pop-ups will still continue although we are also seeing some fatigue as some businesses now use pop-up as their chance to have regular blow-out sales and other repeating offerings that dilute the surprise factor and excitement of pop-ups. Perhaps there will be a new, more exciting reiteration of the pop-up that will bring back the excitement?
In the manner of the ice cream truck, milk man, shoe-polish box and hot-dog stand of the past, mobile offerings are also growing around the world. From food carts and mobile cafes to bike services and mobile pet spas, new, exciting businesses are popping up as mobile carts.
Many cities have been forced to alter their laws to accommodate these temporary, mobile businesses that often do not fit under the laws created for permanent, bigger operators. We think this is all to the good. While laws and regulations are necessary, they need to become much more flexible and nimble to adapt to startups and small operators that add desirable flavor, colour, excitement and convenience to their surroundings.
Also part of the mobile, portable phenomenon, are the various dwellings, hotels and businesses housed in repurposed shipping containers. The Illy Café in New York in 2007 garnered a much attention and a multitude of reiterations of the idea now pop up daily.
One valuable consequence from striving for smaller, portable, mobile, inexpensive, sustainable pop-up is that many forms of temporary housing options, portable clinics, schools and water purification stations and so on have become not just curiosities but real solutions in far-flung places and/or difficult conditions to help in areas of catastrophe, extreme poverty and environmental crises.
As poverty has often turned out to be the mother of invention, we believe that this is one area where sometimes even the silliest-seeming ideas can actually be transformed into real relief and smart solutions where they are most needed. As we who have everything in excess "play with our food", perhaps we will in the process find ways – and the will – to relieve suffering everywhere.
We also believe that our exasperation with conspicuous consumption – that is partially expressed in our desire for everything smaller – has also helped to bring about a new kind of helping culture. We are starting to consider the consequences of all of our actions as companies, teams and individuals, rather than doing whatever it takes to momentarily satisfy our desire for the next fix for our inner emptiness, or to blindly and impotently try to meet the shareholders' relentless demand for bigger profits.
The small mobile business is tied to another aspect of this trend – locality. More and more people want to buy local, not just food but other products and services as well. And while it is difficult for a small, new operator to compete with the prices of an established, strong brand, we feel that local businesses and local initiatives will continue to grow in popularity.
What we do know as well is that whether a business is local or small, it still has to meet the needs of today's demanding clientele.
Many small operators seem to believe that just because they are passionate about their business and because they want to do it, customers somehow owe them their patronage. That is not the case today, and it never was.
We will not part with our time or money – at least not repeatedly – if we are not getting great service and great products. Being small, local or independent will carry a business only so far. A loyal customer base will not develop out of pity or shame.
Professional branding is also a given today. And that does not necessarily mean having to spend a lot in the creation of logos and package design, although it may mean those as well. What it does mean is that if you are going to succeed, you will need to be able to charge a premium price. And to charge that price, you need to look and behave like a brand that knows who it is and what it does and why it exists.
Clear messaging, cohesive visuals, well thought-through customer experience, professional staff – all of these are important. And yet, you can achieve all this without having to appear or behave like a pretentious branding exercise with a fake story and dumb logo. It is all about knowing who you are, what you offer and why your valued customers should spend their time and money with you. All the basics of business still apply.
The last aspect of the Small is the New Big trend that we'll cover in this article is what we'll call Rogue concepts. They incorporate many of the other aspects of the trend with the added appeal of a grass-roots initiative.
Concepts such as Diner en Blanc, Helsinki-born Restaurant Day, Cleaning Day are part of this.
The Rogue concepts add the empowering angle of people taking to the streets, creating their own "brands", doing it their way, breaking the rules.
This, perhaps more than any of the other aspects, speaks to the true core of the entire trend. We are tired of giving our power – and time and money – to the Big Brand. There's an undercurrent of sophisticated protest. Call it idle nonsense of the well-heeled, if you like, but we think it is part of a serious undercurrent. The world of Wall-E is not quite as absurd as we'd perhaps like to think and the power to change it is in our hands. - Tuija Seipell.
Images 1,2,3 - Happy Bones Cafe, NYC, images 4/5 - Grey Goose Pop up bar in Edinburgh., Image 6 - Intelligentsia coffee van, Image 7 - Sigmund Pretzels, Image 9 - LA Distributrice - Montreal, Image 10 - Omotesando coffee - Japan, Image 11 - Velopresso Mobile Espresso bar, Image 13 - Box Park - London, Last image - Homer Wine packaging
Cooking is a serious and competitive business and professional cooking schools can have the air of military camps where fear and strict order dominate. Nothing wrong with that in the world of celebrity chefs, fame and Michelin stars.
But for the rest of us, cooking is either a fun and enjoyable creative endeavour or a boring daily necessity best avoided at all costs.
Many consumer-facing cooking schools, sensing a growing market niche, are offering relaxed, fun classes in cool surroundings that don't intimidate the participants.
The all-female Japanese ABC Cooking Studio has more than 125 casual cooking studios in Japan, Hong Kong and China.
High-stakes chefs train elsewhere, but ordinary women who love sophisticated cooking in a happy, relaxed atmosphere flock to ABC whose studios draw more than 250,000 participants per year.
Their latest location, in Huangpu, Shanghai, China, is a new take on their already relaxed approach to cooking. Designed by Prism Design under the direction of Reiji Kobayashi, the new studio is all white, soft and friendly.
Black ceilings, light wood accents and white main features keep the studio's ambiance clean and professional, avoiding the all-so-common trap of too cute that would have opened up with the introduction of pink, baby blue or yellow.
You can relax now and forget all of your bad memories (should you have any…) of drab and dreary home economics classes because the newest cooking schools are cool.
It is true that The Culinary Art School in Tijuana, Mexico is not of the high-school variety – it is for serious chefs with high aspirations – but it oozes a new, cool confidence that could potentially turn even the most nonchalant teenager into a passionate chef.
The elegant use of wood is the key attribute in The Culinary Art School. Its new building was designed by San Diego, California-based Jorge Gracia Arquitecto whose founder, Jorge Gracia, was born in Tijuana in 1973.
The entire school complex carries an air of strict order, almost an ascetic solemnity. If you didn't notice the stoves or wine racks, you could mistake this for a place of religious study.
And, passionate chefs certainly express a fervour for food, ingredients and cooking that could be likened to religious zeal. It is easy to imagine how the colours, textures and aromas of various ingredients stand out in this kind of environment. It is like a stage for culinary creation or like a frame for gastronomic artwork.
Also in the category of cool cooking schools is the Sydney Seafood School established in 1989 and completely refurbished for its 20th anniversary. It conducts cooking classes for all skill levels and draws more than 12,000 students annually.
Words such as handsome and sexy come to mind when you look at this space, the creative work of Dreamtime Australia Design, based in Sydney, Australia.
Some time ago, we have featured Dreamtime-designed Churchill Butcher Shop in Sydney.
In Sydney Seafood School, a tactile intrigue, and a contrast between serious study and serious fun, are evident in every space. The school's entry wall is a honeycombed sandstone creation by sculptor Michael Purdy.
The dark and impressive hands-on kitchen looks formidable with lots of shiny stainless steel and glass, but its gravity is lightened by chalkboard walls with "fish graffiti" as art. The cool auditorium's walls are lined with Icelandic fish leather. In the dining room, the harbour view competes for attention with a row of fun fishnet chandeliers and their more than 6,000 little globes. Where do we sign up? Tuija Seipell
Blame us, Norwegian designers and/or their possible dislike of communication, or a slight language barrier, but Norwegian design is not often seen in design media.
We would love to change that and we are currently liking the award-winning work of Oslo-based Inne Design's Interior Architect Vigdis A. Bergh.
We noticed her work with hair salon and spa INCH whose owner Kirstin Arnesen is clearly onto something. Her little unisex emporium for the balance of body and mind has been gradually growing in Oslo.
We love the design features Inne Design brought to the first store. The eclectic mix of custom-furnishings and individual finds from flea markets and antique stores creates a fun and interesting environment. Also worthy of mention is the ocreative repurposing of such simple pieces as the retro round tables fitted with mirrors that can be removed should they be needed for serving drinks or buffet food at events held in the space.
We like the flexibility, the balance between the feminine and the masculine, and the raw and funky concrete flooring and street art contrasted with velvety plush seating and classic pieces.
Another project worth a note by the same design team is Melkerampa.- Tuija Seipell.
Entering the Hair Do hair salon in Chiba, Japan, is a surprising experience. No pink or frilly fake-spa softness, nor overly stark funky or shiny hair salon set-ups, just cool balance.
In this new, two-story building, with the upper-floor interior made to look like an old loft, there's an overall sense of light and space and breathing room – our definite favorites.
Add to that the monochromatic wood-tone paneling and unpretentious furnishings, and we have a setting with real composure.
What makes this salon even more attractive, is the two-story glass wall that gives the clients something additional to look at than just themselves, and adds natural light as one of the main design components.
Located at the Chiba monorail station, the salon also adds some visual interest to the commuters' daily routine.
The total area of the high-volume salon is 106 square meters (1,141 sq.ft). The architect and designer of the salon is the 36 year-old Ryo Matsui whose retail, office and residential work often includes wood paneling, monochromatic interiors and rounded edges. - Tuija Seipell
Photographs: Daici Ano
Wood is both universal and unique. No other material is as deeply embedded in the history, culture and life of humans worldwide as wood, yet every single piece of wood is unique.
The color tone, texture, durability, flexibility and even sound qualities of different tree species have puzzled and challenged artists, architects, designers, builders and artisans for thousands of years.
Still today, nothing matches wood in versatility or beauty, so it is great to see how today's designers and architects continue to face the challenge of wood, and use it creatively to interpret sleek, modern designs.
They use wood to meet their current needs and desires for which wood is ideally suited. People seek calm surroundings, simplicity and minimalism to soothe their frayed nerves and to counter the constant visual overload they face. Wood's warmth and natural beauty works wonders for creating a sense of balance and calm.
People also look for sustainable alternatives, eco-friendly options, greener solutions. When harvested, managed and used sustainably, forests are still the source of the greatest material on earth.
We especially love the influence of Scandinavian and Japanese traditions that we can detect in today's wood architecture and design. Minimalist, functional, beautiful, and light in both color and weight.
Scandinavian building and design traditions are based solidly on the use of wood. Finnish modernist master, architect Alvar Aalto, stunned the world with Living Wood, his design for the Finnish Pavilion for the Paris World Exposition in 1937. In the pavilion, he combined both traditional and modern architecture and showcased his functionalist design sensibilities. It was considered one of the boldest and most innovative pavilions of the Expo.
Earlier, Aalto's exploration of the limits of bent wood and mass production had resulted in the Paimio chair (1931) and other furniture classics, and had a permanent impact on how furniture looks even today. Aalto's work influenced many other modernist masters including Charles and Ray Eames and Eero Saarinen.
The use of wood in Japanese architecture and design is characterized by austere construction methods, the lightness of materials, the connectedness between indoors and outdoors, and the way in which buildings merge with their surroundings.
With hardly any furniture used inside, Japanese master craftsmen were able to focus their skills on the buildings themselves, on skilful joining of sections without nails, and on revealing, rather than covering or adorning, the original texture and tone of the wood.
Wood as a material has held a charmed place in architecture and design for both its simplicity and complexity. It lends itself to imposing, bulky structures, yet also yields to delicate, undulating forms that seem lacy and transparent.
We love this lightness and elegance, the play of light and shadow, the countless tones of color that can be achieved with skilful use of wood both structurally and decoratively.
In more and more residential projects, both big and small, architects and designers are finding new, creative ways to reveal and highlight the beauty and versatility of wood. They manage to create structures that appear current and cool, yet also exude a classic, timeless elegance.
Every day, we come across images of fantastic single-use residences, recreational cottages, furniture, decks and patios, where the qualities of wood are perfectly matched with the users' needs and the requirements of the surroundings as well.
In retail and hospitality, wood is also making an impact. We love the blocky, clean look of the Aesop stores. At the other end of the spectrum a good example is the lightness and playfulness achieved in RDAI Architects' use of wood-slat "huts" as departments in the Paris Hermès store built inside an old hotel swimming pool.
In not just eco-lodges, but also in luxury resorts, spas and hotels, wood is becoming the material of choice. As guests are looking for a retreat, a sense of being back in nature, a quilt-free, tranquil vacation, resorts are responding with wood-frame structures, wood interiors and sustainable solutions that also look fabulous.
Wood is not trendy yet it is incredibly cool. It is a demanding, noble, ancient, living material that we have the privilege to use and enjoy. In wood, the architect, designer and builder face the exhilarating challenge of the sculptor — to reveal the character of the specific species, the individual tree. And we, the viewers and users of their work, have the opportunity to discover it for ourselves. We are looking forward to more. - Tuija Seipell.
At TCH, we are so obsessed with wood that we even created Treelife, an event to showcase the most innovate work using wood in the design of Treehouses.
We became obsessed with inflatables ever since we created the Mini Inflatables. The reaction they generated told us that we were on to something – we were not the only ones crazy about them.
We wanted to see more, do more and create more of them, and as always, we wanted to see what ideas others could come up with. So we launched a competition and asked for submissions.
Tons of suggestions came in, one more imaginative than the other. But to us, many of them were too complicated and cumbersome, trying a bit too hard.
But finally, we can reveal the winning design. It is a masterpiece in minimalism and function created by Pablo Crespo Pita from Spain.
Pablo's CHAT inflatable is a series of three models with unlimited ways to link and enjoy them. We love the flexibility, practicality and the juicy colors.
For two weeks only, you can now purchase the CHAT Inflatable from here.
Pablo's other entry and our favorite is Air Couture below
Should you be so lucky as to be asked to design a Film Museum, how would you feel? Most likely, overwhelmed. The many juicy aspects of the dream factory of film business make one's head spin! The technology – from the first scratchy silent films to today's 4D experiences. The genres – from drama and documentaries, to sci-fi and animated movies. And the intrigue and mystery of film as propaganda tool and promotional vehicle. The stars and the drama of their lives online and off. The various awards, the gowns and the glitter. Even the people behind the movie cameras – the directors, the movie moguls and the critics – all seem to carry an extra aura of glamour and fascination. Add to that the sets, the locations, the props, the car chases, cliff-hangers, fantasy worlds and the historical epics created and recreated through film. Indeed, no lack of material.
When Tilman Thürmer the German-born architect and founder of Coordination Asia (that we have covered before), was selected as the Art Director of the Shanghai Film Museum, he had "film" and "Shanghai" as his directives. No more, no less.
The Shanghai Film Museum, opened on June 17 and currently hosting screenings for the nine-day 16th International Shanghai Film Festival, is therefore a highly commendable feat in its minimalist yet immersive approach.
It's goal is to celebrate and introduce to visitors the past and future of Shanghai's involvement as the centre of Chinese film. The 15,000 square-meter, four-storey building is located in a former film studio in downtown Xujiahui.
The new museum involves more than 70 interactive installations and 3,000 historic exhibits. The visitors can ad-lib for famous Chinese films in a real sound studio, walk the red carpet, or Carpet of Light, or learn about animation, post-production, sound and live broadcasting in fully equipped studios.
Thürmer chose light and shadow, black and white, as the main themes, with grays and metallic accents referring to the silver screen, the film equipment and the glittering awards.
We especially love Thürmer's involvement in the other aspects of the customer experience as well, not just the design of the actual space and exhibits. Too often this is all left to the last minute and not considered important. Yet the visitor interacts with people and with the entire experience, not just the walls and "props."
Thürmer's role as consultant and art director was extended to the communication design and operations of the museum. He created a visual identity and a graphic design concept, and consulted the museum on selecting and training the right team.
"The opening of the new museum is the start of a longer development process," Thürmer says. "The coming year will be about professionalizing operations, visitor services and management. To me, this museum can be considered a success when it stimulates a new generation to identify with Shanghai Film. I will be satisfied when I see young people leaving the museum inspired, thinking: 'The Shanghai film industry, that's what I want to dedicate my future to.'"
We love this kind of thinking! -Tuija Seipell.
The Cool House, the first ever pop-up concept created and curated by The Cool Hunter (TCH), was an unprecedented run-away success at Pacific Bondi Beach(10 days), Sydney, Australia and at Rockeby Studios, Melbourne (4 days).
Close to 10,000 people attended both events. Media attention, both online and off, and the overall reaction of the public – both in person and online – was overwhelmingly positive and enthusiastic.
To take advantage of the momentum and to realize the incredible HOUSE potential of The Cool HOUSE concept, TCH will now take this concept to the next level.
TCH will create a temporary pre-fab house, designed by an American architect and an American interior designer – selected though an invited architecture competition – and located in yet-to-be-determined spot in New York City.
The house will be open for 2/3 months and celebrate a selection of items and their designers. The space will be personally curated by TCH, and include the most desirable and most covetable furniture and designer accessories for the home including fashion.
New global designer destination:
The Cool House will create an exciting new designer "destination" and draw attention to American architecture and design.
The global media attention for this exclusive concept will be unprecedented in part due to the unequalled reach of TheCoolHunter.net blog of more than 2 million monthly readers plus other social media outlets (Instagram 240,000 followers, twitter 294,000 followers, plus 210,000 readers-strong newsletter subscribers. The partners involved in this concept will together reap the benefits of their collective marketing power.
For, developers, brands and marketing opportunities, contact us here.


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