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Li-Fraumeni syndrome
Other Names for this Disease
- Sarcoma family syndrome of Li and Fraumeni
- SBLA syndrome (Sarcoma, Breast, Leukemia, and Adrenal Gland)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
sarcomas (cancers of muscle, bone or connective tissue), breast cancer, brain tumors, and cancer of the adrenal gland (adrenocortical carcinoma), though there may be an increased risk to develop other types of cancer as well. This condition is caused by mutations in the TP53 gene and is inherited in an autosomal dominant manner.[1]
Li-Fraumeni syndrome is a condition that greatly increases a person's likelihood of developing cancer, particularly at an unusually young age. Affected individuals also have an increased likelihood to develop more than one cancer during the lifetime. Cancers most often associated with Li-Fraumeni syndrome include
Last updated: 1/17/2013
- Schneider K, Garber J. Li-Fraumeni syndrome. GeneReviews. February 9, 2010; http://www.ncbi.nlm.nih.gov/books/NBK1311/. Accessed 8/8/2012.
Your Questions Answered
by the Genetic and Rare Diseases Information Center2 question(s) from the public on Li-Fraumeni syndrome have been answered. See questions and answers . You can also submit a new question.
On this page
Basic Information
- Genetics Home Reference (GHR) contains information on Li-Fraumeni syndrome. This website is maintained by the National Library of Medicine.
- The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public. Click on the link to view information on this topic.
In Depth Information
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Li-Fraumeni syndrome. Click on the link to view a sample search on this topic.
Insurance Issues
- The Social Security Administration (SSA) created the Compassionate Allowance Initiative to speed up the processing of disability claims for applicants with certain conditions. Click on the link to view the Compassionate Allowance information for adrenal cancer, a cancer associated with this condition. More information about applying for Social Security disability benefits is available online.
Link: https://secure.ssa.gov/apps10/poms.nsf/lnx/0423022090
Other Names for this Disease
- Sarcoma family syndrome of Li and Fraumeni
- SBLA syndrome (Sarcoma, Breast, Leukemia, and Adrenal Gland)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


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Who is the best character from any of Alisons books?
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Who is the best character from any of Alisons books?
Can I choose 2.........coz I like Hem and Maerad......their characters are brilliant.........
I'd say Ardina is purty damn good, besides the whole 'doomed' to a shallow enternity on earth and all... she has all those out there Elidhu powers, and she had really good 'connections' :D
Runner up is of course... shexy shexy Cadders, he's dark and mysterious and somewhat powerful *sigh* he's only a book character tho :( :rolleyes: :D
cadvan and mearad
Originally Posted by Gemini
Ah, yes, I almost forgot about Ardina.........I based a character around her a bit....Im in the middle of writing a story and need all the help I can get to keep my attention on it............I borrowed a couple of the chracteristics from your books, Alison..........but I doubt Ill finish it.........
Oh yes and Cadvan.........hes a good character but I prefer Maerad.......yes Maerad is good...........she WILL prevail!! :D ;)
I like Cadvan, Saliman, Silvia, Ardina and Arkan :D ..I can't choose just one!! :rolleyes:
cadvan and the winter king. i think those characters are the most deep, emotionally. maerad has all the components to be a character with so many levels... but i think her immaturity (appropriate to her age) prevents this. this is not a criticism of the writing - i think the level of angst is quite telling of maerad's age and i connect to it. she's one of those characters i can see growing up and evolving...
i like the winter king because he seems so conflicted - caught between being immeasurably old and a young man still unsure of himself.
cadvan just makes me giggle. *giggles*
Sorry to be a predictable fan-girl but ...
cadvan and Ardina. they have intiguing pasts and very complex personallities. but i also like silvia,malgorn,hem and arkan.
I like Maerad the most, then Cadvan, Hem, Saliman etcccc. Even though he hasn't featured that much, I also really like Nelac. I wish we'd got to know him more. Same goes for Dernhill :(
my fav's would have to be Silvia, Nereli and Cadvan. i'm sorry but i always prefer sidekick sorta minor characters to teh protagonist of a novel. mayb just a me thing.
~ Tari
hmmmph hard to choose a favourite. Top 3 would have to be Hem, coz he's kinda that shy tortured soul type, Cadvan of course coz he's all mysterious and powerful and Arkan coz hes kind of enchanting and all he wants is the song, can ya blame 'im for that? its sounds pretty good, who wouldnt want it? :confused: :p
I like Nelac, Maerad, Arkan, Ardina, Hem, Cadvan and Mirka they're all very, vey interesting
Maerad is my favourite!
I liked Darsor & Imi, and Indik (for a pretty small part), and I liked the mountain lion in book one. But ultimately, my favourite characters are Arkan and Cadvan. They're just so amazingly deep and thought-provoking.... and wonderful!
Emerald :) :) :)

subset: commoncrawl


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Where are 'Xena,' 'Hercules' stars today?
POSTED: 02:56 PM PDT Mar 27, 2012
UPDATED: 11:00 PM PST Jan 15, 2015
With Friday marking 20 years since the 1995 debut of the fantasy TV series "Hercules: The Legendary Journeys," let's see what the show's stars are up to today.
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quote:However, I was FFWDing last night and caught a glimpse of his pink bird sitting on his head and had to rewind it and watch that shite.
quote:The dude who sang Crazy was good..why the hell didn't anybody turn around..? That was a cool arse version of that song and he sounded great IMO.
quote:If I see one more bitch whining about being bullied Im gonna kick a frickin puppy. This has gotten out of hand. Its like its soooo cool now to have issues that everyone has grown up with at one time or another. I automatically root against them for being weak minded cowards.
quote:The dude who sang Crazy was good..why the hell didn't anybody turn around..?
quote:so tonight is just a compilation of shite we already seen?
quote:Yes, and it was completely worthless. At least show some full performances of the people that were glossed over before. frick.
quote:So they showed none of the ones that were montaged?


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Featured Profile
Jonah Lehrer is a contributing editor at Wired and the author of How We Decide and Proust Was a Neuroscientist. He graduated from Columbia University and studied at Oxford University as a Rhodes Scholar. He's written for The New Yorker, Nature, Seed, The Washington Post and The Boston Globe. He is a contributing editor at Scientific American Mind and National Public Radio's Radio Lab.


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This where the flash should stand...
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What does CTS mean in Mathematics?
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Mission-Style Table Lamp
Item #37435
Price: $200.00
Availability: Out of stock. This item is no longer available for purchase.
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A Masterpiece of Contemporary Illumination. Like a 1912 Frank Lloyd Wright window held in the collections of our Hirshhorn Museum and Sculpture Garden, the sleek base of this handsome Mission-Style Table Lamp is complemented by the simple geometries of its 248-piece handcrafted glass shade. Twin pull-chain sockets take 75w. max bulbs (not included). Resin base with vintage bronze patina. 23"h. with 16"sq. shade.
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Refine favorite living spaces or sanctuaries of productivity with these tastefully curated accessories and devices—each inspired by an object in our extensive collections.
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In a resignation letter submitted to Sheriff Jerry Carver Monday, Beck's resignation was effective immediately. His position as chief deputy and arson investigator has been filled by Deputy Lee Taylor. Before the promotion, Taylor was the department's criminal investigator.
Beck had been with the department since Carver took office as Carroll County sheriff in January 2008.
Prior to Beck's resignation, he was demoted from chief deputy and arson investigator to deputy in a sweeping reorganization of the Carroll County Sheriff's Department by Carver following the trial and subsequent guilty pleas of John Beck and Curtis "Bela" Alford. With the demotion, Beck's pay was cut substantially.
"I had to make some changes," Carver said at Monday's Carroll County Board of Supervisors meeting in Vaiden. "There were things I wasn't aware of, decisions made that night, until they came out in the trial."
Carver said he preferred not to say what things he learned that caused him to reorganize his department, as they were "personnel matters."
Beck is the brother of John Beck, who was sentenced to serve two years in prison for his shooting into an occupied vehicle and malicious mischief, both felony charges, in connection with events that occurred on the night of March 9, 2011 in Holmes County. Beck admitted to shooting nine times into the back of a vehicle driven by Odessa Williams of Lexington, but he argued his actions were made in self-defense.
Alford pleaded guilty to conspiracy to obstruct justice, also a felony, and was sentenced to probation with non-adjudication status for one year.
During Beck and Alford's trial in Lexington earlier this month, it was established that after shots were fired into Williams' car, Williams fled the scene, eventually exiting the vehicle and running into the woods. After he abandoned his vehicle, and the Holmes County deputies did not come to remove it, the car was towed to the Carroll County Emergency Operations Center at the direction of Scott Beck, who as chief deputy instructed Beck and Alford on what procedure to take.
Carver reported several staffing changes at the sheriff's department as part of the reorganization. Longtime deputy Travis Gatewood was named the DUI officer, and part-time deputy Kristopher King was promoted to a fulltime deputy.
Deputy Rob Banks is now the department's criminal investigator and narcotics investigator. At the Carroll Montgomery Regional Correctional facility, Deputy Therrell Turner will receive a pay increase.
CR 78 bridge gets attention
Beat One Supervisor Terry Herbert will get an 84-foot by 12-foot by 50-foot pipe to replace a bridge that burned earlier this month. The cost of the pipe will be around $6,000, the funds coming out of the county bridge fund. The vote passed 4-1, with Board President Honey Ashmore the lone dissenting vote.
Ashmore argued he did not think it was fair for the money to come from the road and bridge fund, since that money is divided equally between each beat.


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Click above for our current digital issue
Our July/August cover feature on the impact of mobile on sales and marketing cites separate studies by Forrester and Oracle. You can download the full Forrester research report here (it requires completing a registration form for survey sponsor Hybris Software). The Oracle report, "2013 B2B Commerce Trends," can be found here.
"How can Derek Jeter help your sales? Seattle sports broadcaster Jen Mueller says a little sports talk can go a long way in the business world. Read an SMM Q&A with Mueller here.


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News outlets have heralded a new report finding the plastic chemical BPA safe for humans. Turns out, it's an unpublished study by an industry-connected scientist.
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If we can't plead stupidity, what else is there? How do we live with ourselves? Is it all the stuff we buy that manages to numb our brains and consciences? When I see a headline like this one at Bloomberg today, World Needs Record Saudi Oil Supply as OPEC Convenes, there's just one thought that pops into my head: what the world needs is for us to stop doing this thing we're doing. Even apart from peak oil concerns, it's obvious we're going to run out at some point or another, and it doesn't matter whether that's tomorrow or at some other point in the future, though we do know it's not going to take another 100 years, or even 50. And nothing will ever take the place of oil; once those unique carbons are gone, that's it, we'll have to find a completely different way of running our societies, and if we're not smart enough to prepare for that beforehand, we'll be cats fighting in a sack and use the last scraps to kill off each other. And our legacy won't be the Greek thinkers and Picasso and Dostoyevsky and Walt Whitman and Maria Callas, since there won't be the means for our children anymore to share what makes man great between them. Our main legacy will instead be bloodshed, we will have gone the exact same path that any non-thinking or even primitive organism would have taken, who don't have opera or philosophy or poetry to their name.
Es Doctora en economía por la Universidad de Columbia. Como asesora del Secretario de Hacienda representó a la Secretaría en la negociación del Tratado de Libre Comercio de América del Norte (TLCAN) en el capítulo financiero. Se especializó en regulación bancaria y fue Vicepresidente de Supervisión Bancaria en la Comisión Nacional Bancaria y de Valores (CNBV) habiendo diseñado el sistema de supervisión por riesgos, y participado activamente en la reestructura bancaria que tuvo lugar durante la crisis bancaria de los 90´s. bancos internacionales a través del Comité de Basilea, del cual la Dra. Armendáriz formó parte para evaluar el impacto de las reglas en bancos de países emergentes. En 2001 regresó a México como asesora del Presidente del Consejo de Administración de Banorte. En la actualidad es Directora General de Financiera Sustentable, Consejera de Banorte, y Asesora de varias empresas para mejorar su Gobierno Corporativo, Administración, y consecución de fondos para crecer.
In the last few weeks, we've seen 2 astonishing announcements, one from the CEO of Royal Dutch Shell (RDS), and one from the Chairman of British Petroleum, acknowledging the problem of climate chan...
I was in Ann Arbor at the University of Michigan interviewing Ricky Rood the other day - and that's the question I asked him. Dr. Richard Rood is a former NASA Atmospheric Scientist now teaching at...
5 years ago, climate deniers staged a fake "scandal" by hacking in to the University of East Anglia's Climate Research Unit, and selectively quoting stolen emails to a compliant and cooperat...
Naomi Oreskes, author of Merchants of Doubt, on finding out that she was being attacked on the floor of the Senate by James Inhofe, the Strom Thurmond of climate denial. The movie based on Oreskes ...
Above, my newest "This is Not Cool" video focuses on the backstory behind "Merchants of Doubt", the new documentary inspired by Naomi Oreskes' and Eric Conway's book of the same name. The centerpi...
Este informe proporciona un análisis exhaustivo de los datos reales de producción de los siete principales campos de gas y petróleo de lutitas de los Estados Unidos. La producción conjunta de estos campos representa el 89% de la producción actual de petróleo de lutitas y el 88% de la de gas de lutitas, y constituye la principal fuente de suministros de hidrocarburos procedentes de lutitas según los pronósticos hasta 2040 de la EIA: un 82% de la producción prevista de petróleo y el 88% de la de gas.
This is the year the "dam of denial" will break and the momentum for climate action will become an unstoppable flood. It will be messy, confusing and endlessly debated but with historical hindsight, 2015 will be the year. The year the world turned, primarily because the market woke up to the economic threat posed by climate change and the economic opportunity in the inevitable decline of fossil fuels. That shift will in turn unlock government policy and public opinion because the previous resistance to action argued on economic grounds, will reverse to favour action on economic grounds. Before I argue for this conclusion, let me explain what I mean by the "dam of denial" and why the concept is so important to understanding what's underway.
It has been a tough couple of years in the effort to unite labor, community, and environmental groups, an alliance that has always been strained. The extractive energy sector—coal, gas, oil—has historically had strong union representation and well-paying jobs. Tensions rose in 2011 after the Sierra Club escalated their campaign to close coal plants and 350.org, the climate protection group led by activist Bill McKibben, called for a halt to the Keystone XL Pipeline project. Even Obama's relatively mild order this past June on reducing pollution from power plants was opposed by the International Brotherhood of Electrical Workers (IBEW) and the Mineworkers. "Where is the transition plan for workers?
Russell Roberts's curator insight,
February 27, 11:27 AM
A cautionary tale for all of us. Unless we work together and pool our intellectual, cultural, and social resources, the future of humankind will be perilous and even final. Human activity helped create the mess we're in and human activity must resolve the issues before our window of opportunity closes. Territoriality, ego, and thirst for power must be modified if we as a species are to survive. Aloha, Russ.
WASHINGTON (Reuters) - Hillary Clinton's connections to oil and gas interests has created a dilemma for some environmental groups, troubling activists for whom she would be the natural candidate to support
North Carolina's environmental agency cited Duke Energy on Wednesday for coal ash contamination of groundwater at its Asheville power plant.
Europe's approval system for genetically modified (GM) crops is "fundamentally flawed", say MPs. The process assumes GM plants pose greater risks than conventional plants, which is not backed by scientific evidence, the parliamentary Science and Technology Committee report says. It calls for GM crops to be regulated on the basis of their characteristics not the method used to produce them. |
But global warming wasn't the sole culprit in the 2009-2010 event.
More from my chat this week with Dr. Richard Rood at the University of Michigan Department of Atmospheric, Oceanic, and Space Science - soon to be renamed the Department of Climate and Space Scienc...
The stage is set for massive action on climate change - a clear majority of Americans now see climate as a moral issue. Below, a new poll by Reuters shows that two thirds of Americans believe thei...
If you happen to be out this weekend looking to turn off for a couple hours, you could probably do worse. Something here to offend everyone, and make you kind of hate yourself for laughing out loud...
If a senator throwing a snowball in February is supposed to disprove rising temperatures, then what do record highs in January back home say? In Oklahoma City, daily high records have been broken each day for the past three days.
Andrew Freedman in Mashable: The eastern U.S., as well as parts of Canada, sticks out for having the most unusually cold conditions on the planet. In fact, much of the rest of North America — inclu...
Readers are aware of two recent high profile announements from Shell and BP, calling for a price on carbon and an enlarged discussion of climate change globally. I recently watched a long lecture b...
If you're looking for a quick ~5-10 minute presentation on why local matters you may find this useful. Slides and transcript included.
In the grand poker game of geopolitics, energy is often the wild card. That's why the Middle East is such a mess: Great Powers (first Britain, more recently the United States) have been installing, propping up, toppling, threatening, or bribing regimes in that region — almost always to the detriment of indigenous populations — ever since the first oil discovery there prior to World War I. Oil and natural gas interests are clearly implicated in current turmoil in or around Libya, Iraq, Syria, and Iran—and also Ukraine. In each instance it requires some historical context to understand the peculiarities of the situation; let's focus for a moment on the last of these countries.
Fukushima fishermen appear to have finally run out of patience with Tokyo Electric Power Co.
U.S. EPA's effort to curb air pollution drifting across state lines was under siege in federal court again today, and it appeared vulnerable to the challenge from states and industry despite emerging victorious last year from the Supreme Court.
Conservationists claim environmental concerns have been ignored in runup to regional elections in decision to reopen Aznalcóllar mine that caused one of Spain's worst ecological disasters 17 years ago
A report released Wednesday shows that about 60 million metric tons of food is wasted a year in the United States, a problem that contributes to climate change and to the loss of natural resources like water and land. |


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An Open Mind
Photograph courtesy Dario Piombino-Mascali, EURAC, and Clinical Anatomy/Wiley
A mounted human head strikes a brain-teasing pose—just one of eight forgotten but stunningly preserved 19th-century Italian mummies whose secrets of preservation have only recently been unraveled.
Working in the town of Salò, anatomist Giovan Battista Rini (1795-1856) "petrified" the corpses and body parts by bathing them in a cocktail of mercury and other heavy metals, according to new chemical analyses and CT scans, to be described in a future issue of the journal Clinical Anatomy.
The study marks the first time a collection of Italian mummies made for anatomy studies has been analyzed in detail, according to study team member Dario Piombino-Mascali, a forensic anthropologist at the Institute for Mummies and the Iceman in Bolzano, Italy.
(Pictures: "Lifelike 'Wet Mummy Found During Roadbuilding.")
—James Owen
Published February 17, 2012
Head Trip
Photograph courtesy Dario Piombino-Mascali, EURAC, and Clinical Anatomy/Wiley
A motley assemblage of mummified heads and busts from the 1800s in various states of anatomical undress await their turn on a CT scanner in a hospital near Salò, Italy—a long way from their home in a Brescia, Italy, hospital.
Intended for teaching and study, the collection was made using a method known as petrification. The technique, which substitutes organic for mineral matter, has made the specimens very hard.
"They have a wooden consistency," said Piombino-Mascali, a past grantee of the National Geographic Society's Committee for Research and Exploration. (The Society owns National Geographic News.)
"In Italy we had several people who petrified human cadavers" in the 19th century, he added. "Some of them really made a great job."
(See a picture of the Sicilian "Sleeping Beauty" mummy also studied by Piombino-Mascali.)
Published February 17, 2012
Had Some Work Done
Photograph courtesy Dario Piombino-Mascali, EURAC, and Clinical Anatomy/Wiley
The witchlike appearance of a 19th-century woman's disembodied head (pictured in a CT scanner) is heightened by fake eye caps and hair long ago added for realism.
Scans revealed that the mummies' original eyes, though shrunken, had survived behind the prosthetic versions.
Giovan Battista Rini, who made the mummies, "wanted to make them as realistic as possible, and perhaps he used the real eye to support the fake eye that was put on it," Piombino-Mascali said.
(Pictures: Millions of Puppy Mummies in Egypt Labyrinth.)
Published February 17, 2012
Inside Job
Photograph courtesy Dario Piombino-Mascali, EURAC, and Clinical Anatomy/Wiley
This mummified male head and shoulders were purposely taken apart to show muscles, airways, blood vessels, and other inner workings.
The cadavers were preserved by immersion in chemical baths and by injecting mercury and other minerals into internal body tissues, according to the new study.
"Because there are some vessels that are completely preserved, we have the feeling both techniques were used," since the chemical baths wouldn't have been enough to fully preserve internal tissues, Piombino-Mascali said.
(Explore our interactive human body.)
Published February 17, 2012
Photograph courtesy Dario Piombino-Mascali, EURAC, and Clinical Anatomy/Wiley
Fresh bodies supplied to Rini for his human "petrification" work in the 1800s (such as this male seen in an Italian lab) didn't come only from the hospital where he worked. For instance, two of the mummified corpses in the study belonged to outlaws, Piombino-Mascali said.
Regardless of their provenance, cadavers made to demonstrate internal body parts had their skin and subcutaneous tissue removed prior to preservation.
This was likely done with surgical tools, although reports from the period say that meat-eating insects such as maggots were also sometimes employed, Piombino-Mascali said. (Video: Human Body 101.)
Published February 17, 2012
Image courtesy Dario Piombino-Mascali, EURAC, and Clinical Anatomy/Wiley
CT scans show a mummified head (see the first slide in this gallery) that in the 19th century was surgically cut and peeled to expose the brain.
Chemical analysis of small pieces that had broken off the antique exhibits showed that "an enormous amount of mercury" was used to petrify the human body parts and organs, Piombino-Mascali said. Potassium, iron, barium, and arsenic were also among the preservatives Rini used.
"These chemical substances were probably mainly heavy metals, which would have saturated the piece and made it stone-like," he added.
(Pictures: Mystery of the Tattooed Mummy.)
Published February 17, 2012
Worlds of Difference?
Photograph courtesy Dario Piombino-Mascali, EURAC, and Clinical Anatomy/Wiley
It might be more than 150 years old, but this Italian anatomical mummy, like others in Rini's collection, may look familiar to anyone who's seen the popular "Body Worlds" exhibitions of "plastinated" human corpses.
Whereas Rini's "petrification" technique involved replacing the body's organic matter with minerals, plastination fills human tissue cells with polymers, said Peter Kiefer, spokesperson for the Institute for Plastination, the Heidelberg, Germany-based organization behind "Body Worlds." (See pictures of "Body Worlds" corpses.)
Kiefer agreed that the two collections are strikingly similar looking, despite being centuries apart—and he may soon be able to examine the anatomical antiques up close, along with the rest of the public.
Plans are afoot, study co-author Piombino-Mascali said, for a "Body Worlds"-style display of the 19th-century mummies in a Salò museum.
More: "Cadaver Exhibition Draws Crowds, Controversy in Florida" >>
Published February 17, 2012
The Future of Food
Why Food Matters
How do we feed nine billion people by 2050, and how do we do so sustainably?


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Or find a doctor at another Johns Hopkins Medicine Member Hospital:
David Newman-Toker, MD
Out of State Patients
Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)
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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)
- Associate Professor of Neurology
- Associate Professor of Otolaryngology-Head and Neck Surgery
Centers & Institutes
- Armstrong Institute for Patient Safety and Quality
Dizziness, Facial Pain, Neurology
Research Interests
Misdiagnosis of dizzy patients in the Emergency Department; Recognition and prevention of diagnostic errors in frontline healthcare settings using informatics tools at the point of care
Dr. David Newman-Toker's clinical expertise is in disorders of the brainstem and cranial nerves, including visual loss, double vision, and dizziness. He also specializes in the evaluation and treatment of headaches and facial pain.Dr. Newman-Toker's research focuses on recognition and prevention of diagnostic errors in frontline healthcare settings using informatics tools at the point of care. He is currently conducting a study on the misdiagnosis of dizzy patients in the Emergency Department. Research methods employed by his group include prospective cross-sectional,observational cohort, and case-control studies, as well as surveys and systematic literature reviews.
He holds joint appointments in Ophthalmology, Emergency Medicine, and Health Sciences Informatics, as well as in Epidemiology and Health Policy & Management at the Johns Hopkins Bloomberg School of Public Health.
Dr. Newman-Toker received his B.S. from Yale University and his M.D. from the University of Pennsylvania School of Medicine. After completing his Neurology residency at the Massachusetts General Hospital, he went on to complete fellowships in Neuro-ophthalmology at the Harvard University/Massachusetts Eye & Ear Infirmary and in Neuro-otology at the Johns Hopkins University School of Medicine. He completed his doctoral training in Clinical Investigation at the Johns Hopkins Bloomberg School of Public Health.
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- Hospital of the University of Pennsylvania (Philadelphia PA ) (1995)
- Massachusetts General Hospital / Neurology (Boston MA ) (1999)
- Johns Hopkins University School of Medicine / Neurology (Baltimore MD ) (2002)
- Massachusetts Eye and Ear Infirmary / Neuro - ophthalmology (Boston MA ) (2000)
- Neurology, American Board of Psychiatry & Neurology (2011)
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Strokes, long on the decline among the elderly, are rising among younger adults, Washington Post (06/16/2014)
Stroke Often Missed in ERs, Study Finds, US News & World Report (04/07/14)
Emergency Docs More Likely To Miss Signs Of Stroke In The Young, NPR (04/05/14)
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The Johns Hopkins Hospital600 N. Wolfe StreetSheikh Zayed TowerBaltimore, MD 21287Appointment Phone: 410-955-9441Location MapJohns Hopkins Bayview Medical Center4940 Eastern AvenueBaltimore, MD 21224Appointment Phone: 410-550-5624Location MapJohns Hopkins Outpatient Center601 N. Caroline StreetBaltimore, MD 21287Appointment Phone: 410-955-9441Location MapDepartment/Division
- Neurology


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Healthier Holiday Plan: Which Foods to Portion and Which to Enjoy Guilt-Free
Watching your waistline at holiday dinners doesn't have to be torture. Here's what to look for in holiday dishes and how to lighten up the calorie-packed plates. These notes aren't meant to deprive you of indulgent seasonal dishes. Instead they will help you decide which foods to pile high and which to savor moderately.
More worried about time than your waistline? Breeze through holiday hosting with these easy apps and drinks.


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Tickets for the October 11th San Jose, CA stop of BLACKDIAMONDSKYE are available NOW! Click here to purchase tickets.
Two new dates just announced. Pre-sale and special VIP ticketing packages are available before the public on-sale by clicking the links below:
Aug 21 - San Antonio, TX - AT&T Center - on-sale 7/2 (pre-sale available 6/28)
Sep 11 - Niagra Falls, NY - Rapids Theater - on-sale 7/2 (pre-sale available NOW)
The following headline dates are now on sale! Click the appropriate link
below to buy:
Aug 19 - Tulsa, OK - Brady Theatre
Sep 8 - Cincinnati, OH - Bogarts
Sep 14 - Cleveland, OH - House of Blues
Pre-sale tickets and special VIP packages for the upcoming Deftones US headline tour are now available at deftonestix.com. These packages are extremely limited so be sure to act now before they're gone!
In anticipation of today's pre-sale, and this weekend's on-sale for the upcoming headline dates, we want you to know that $1 from every ticket sold on the headline tour will be going to benefit the Chi Ling Cheng Special Needs Trust, which has been established for Chi's continued medical care. For more information regarding the Trust, please go to oneloveforchi.com.
We're almost there! If the target is hit, one winning "liker" from each tour city will a SIGNED copy of each BDS band's latest album release. That's 19 winners!
To be eligible to win, post on the BDS Facebook wall telling us which date you're attending and tag the BDS band you're most hyped to see. If you tag your friends, even better – spread the word.
Winners announced July 1st
For the first time ever, we're excited to announce limited Deftones VIP packages for the upcoming headline tour this summer.
These premium packages are not available anywhere else and offered exclusively to you at a very limited quantity, so act fast.
Be one of the first to get tickets to see the band live.
1 Pre-sale ticket (face value + service fees)
1 Limited edition commemorative tour laminate
Black $99.95:
Not only will you be the first to get tickets, but you'll also get a limited edition t-shirt and lithograph. These items are not available anywhere else.
1 Pre-sale ticket
1 Limited edition t-shirt
1 Limited edition lithograph
1 Limited edition commemorative tour laminate
Diamond $149.95:
You're among the first to get tickets and part of the select few to get a limited edition t-shirt and autographed lithograph.
You'll also get an invitation to attend an intimate meet and greet with the band.
1 Pre-sale ticket
1 Limited edition t-shirt
1 Limited edition autographed lithograph
1 Limited edition commemorative tour laminate
Meet and Greet with the band
**The Pre-sale/VIP ticket packages above will go on sale Weds June 23 at Noon Pacific Time/3pm Eastern. Check back here at that time for details.**


text: GALLERIES Brooke Hogan Reba McEntire Reba McEntire Carrie Underwood Carrie Underwood Trisha Yearwood Trisha Yearwood Pussycat Dolls Pussycat Dolls Coming Next OR 0 13 Back to Top ▲ Brooke Hogan Brooke Hogan Brooke Hogan Picture 9 AskMen Editors Share on Facebook Share on Twitter 0 Shares A while ago, Brooke Hogan's fame could be summed up in two words: Daddy dearest. Brooke is none other than the daughter of wrestling icon Hulk Hogan. For some time, she was largely recognized solely by her last name, but she is in the midst of changing all that. Continue reading Brooke Hogan's profile. Next Page gallery Comments Show Comments More Like This Promoted Around the Web Special Features


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Many companies spend significant time preparing presentations to potential customers, but overlook the necessity of taking the same care when dealing with their bank manager or a potential investor. Banks and investors look for detailed information to accompany an application for funds. You must be able to write an effective business plan in order to raise capital.
Our Business Consulting team possesses a combination of industry specialization with multi-disciplinary and technological knowledge, which is aimed at helping you enhance your operation efficiency and improve your financial performance. From strategy to implementation, we assist in addressing three critical areas: people, process and technology. We assist in the development and evaluation of strategies, existing systems and processes in those key areas, helping companies think out their vision, strategies and goals. Applying industry best practices, we help companies re-engineer their businesses to achieve improvements and efficiencies.


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Kirk Hinrich (calf) is extremely doubtful for Game 4 on Monday vs. Miami.
Steven Adams (hand) will not suit up for Thursday's game vs. the Bulls.
Kevin Durant (foot) was spotted going through a shooting drill during Thursday morning's shootaround, and he appeared to be pushing off his right foot much better than he was just a week ago.
Paul George (leg) was noncommittal when asked about when he'd be able to return to the court this season.
Nick Young (knee) is being listed as questionable for Friday's game vs. Memphis.
Avery Bradley (left elbow strain) has been ruled out for Friday's game vs. the Pelicans.
Chandler Parsons (ankle) will remain sidelined for at least two more games.
Updating a previous report, JaVale McGee will not be heading to Boston.
Kyle Lowry (rest) said he's making progress and is close to a return.
Patrick Beverley (right foot sprain) is questionable for Friday's game against the Pistons.
Terrence Jones (lower back pain) is questionable for Friday's game against the Pistons.
Bulls head coach Tom Thibodeau said Derrick Rose (knee) is still in the initial phases of his rehab process.


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A Hall of Fame human
For my first four decades, I knew Harmon Killebrew the way I knew most of the 17,000-plus other men who played Major League Baseball: Through ink on a page.
He was the mighty slugger, the six-time American League home run champion. He was the heart of the 1965 AL champion Minnesota Twins, even though an injury that year limited him to just 113 games.
I always thought it spoke volumes about that Twins team that they were able to win the pennant without a dominant season from their best player. Little did I know that Harmon's mere presence in the clubhouse was – quite possibly – a bigger influence than anything he did on the field.
Killebrew's passing on Tuesday brought an end to a life that exuded positive energy. Anyone meeting Harmon in the last 20 years – and having never known he was a player – would have felt it a privilege just to know a man for whom decency and honesty was a way of life.
I know I did.
The fact that he hit 573 home runs and played on 13 All-Star teams seemed secondary to the core values Killebrew promoted by his daily actions. The mere mention of his name brought a smile to the lips of anyone who met him.
If his name was erased from every record book ever printed, Harmon Killebrew would still have been a Hall of Fame human being.
Craig Muder is the director of communications for the National Baseball Hall of Fame and Museum.
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I'm still learning from you, while I'm improving myself. I definitely liked reading everything that is posted on your website.Keep the aarticles coming. I loved it!


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Reviewer: Mary Kara Bucci, MD
The Abramson Cancer Center of the University of Pennsylvania
Ultima Vez Modificado: 13 de diciembre del 2001
Presenter: A. Hagenbeek
Presenter's Affiliation:
Type of Session: Scientific
In 1993, the EORTC lymphoma group initiated a prospective randomized trial in newly diagnosed, low grade non-Hodgkin?s lymphoma (NHL) patients to investigate the efficacy and toxicity of Fludarabine compared to the conventional regimen of cyclophosphamide, vincristine and prednisone (CVP). This report is the final analysis of that trial.
Materials and Methods
Author's Conclusions
Clinical/Scientific Implications
This randomized Phase III study demonstrates the safety and efficacy of Fludarabine as first-line treatment for low-grade NHL. Fludarabine will likely be part of many first-line strategies, and should be studied further in combination with other modalities.
Oncolink's ASH Coverage made possible by an unrestricted Educational Grant from Amgen.
Oct 4, 2010 - Adding the monoclonal antibody rituximab to the standard chemotherapy regimen of fludarabine plus cyclophosphamide significantly extends the lives of chronic lymphocytic leukemia patients compared to chemotherapy alone, according to the results of a phase III trial published in the Oct. 2, cancer-themed issue of The Lancet.


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Mir@k wrote:>>/r/
Q.U. wrote:Tell me where I can watch Wakfu online with eng subs and I'll post a racist US guide to foreigners and foreign countries.
Riz wrote:
not a v-day card per se but relevant.
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The Rocky is the most durable coffee bean grinder available in its price range. It is extremely well made and we highly recommend it for home use and light commercial use. It is a dosing grinder, which makes it especially suited for use with an espresso machine. Although, it would have no problem grinding fine or coarse enough for any type of coffee/espresso machine you might have. The forks that are designed to hold your espresso machine portafilter in place are removable so...
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The Coffee Connoisseur 6 pc Set
Our Coffee Connoisseur 6 pc Set is truly a gift for the connoisseur. Each coffee in this collection is a single-bean varietal harvested at the peak of ripeness to display its enchanting flavor characteristics. This basket includes 1 box each of: Mbeya Reserve, Papua New Guinea, Abyssinian Mokka, Toraja, Colibri, Budan Peak
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Nightingale Residence, Los Angeles
The Nightingale residence has sweeping view of the Hollywood Hills, Beverly Hills, downtown LA, and the Pacific Ocean.
Bruce Damonte
The single-story C-shaped box wraps a south-facing courtyard and swimming pool.
John Edward Linden Photography
The Parlex rain screen provides a tonal counterpoint to the glass and stone. The interiors silver travertine wall meets a mitered wood corner outside the entryway.
The Parlex rain screen provides a tonal counterpoint to the glass and stone. The interior's silver travertine wall meets a mitered wood corner outside the entryway.
The silver travertine entry wall slips through the front door, continuing into the living area.
Direct and uncomplicated, the glass living pavilion transforms into a porch when the doors are open.
The master suite (left foreground) protrudes slightly over the down slope, acting as a deck when the sliding glass panels are opened.
Water flows over a stairwell wall covered in dark, 1-inch-by-inch irregular mosaic tiles.
The plan creates open spaces that blend seamlessly with the exterior.
Courtesy SPF:a
Floors are wire-brushed white oak.
The kitchen occupies a canted, bar-shaped wing perpendicular to the living area.
A wall in the luminous master bath is covered in Ann Sacks tile.
nightingale residence, los angeles studio pali fekete architects (spf:a) culver city, calif.
What's not to love about a C-shaped glass house that faces south, toward views of the Pacific Ocean and the Hollywood Hills? Citing the clear plan and beautiful surfaces, our judges remarked that this house feels welcoming in its swish setting. Zoltan E. Pali, FAIA, created a cantilevered glass box wrapped in a wood-and-resin rainscreen. The public spaces and master bedroom open seamlessly to the courtyard and pool. Secondary bedrooms are on the back side, each with their own little patio.
"The client wanted a warm, textural feel throughout the house," Pali says. A silver travertine entry wall slips through the front door and follows the skylit hall all the way down. Water flows over a stairwell wall covered in dark, irregular mosaic tiles. Floors are wire-brushed white oak. "Materials are used in a painterly way," a judge said. "It doesn't feel overwhelming or forced."
View all 2012 RADA winners.
project credits
principal in charge: Zoltan E. Pali, FAIA, Studio Pali Fekete architects (SPF:a); general contractor/developer: Mauricio Oberfeld, Dugally Oberfeld, Bel Air, Calif.; landscape architect: Andrea Cochran, Andrea Cochran Landscape Architecture, San Francisco; interior designer: Simon Hamui, AEVUM/Grupo Hagan, Mexico City; project size: 9,268 square feet; site size: 0.65 acre; construction cost: Withheld; photography: Bruce Damonte Photography.
product details
bathroom fittings: Hansgrohe, www.hansgrohe-usa.com; cooktop, dishwasher, and oven: Miele, www.miele.com; countertops: Caesarstone, www.caesarstone.com; exterior siding: Parklex, www.parklex.com; hardware: Valli and Valli, www.vallivalli-us.com; hvac equipment: Armstrong, www.armstrongair.com, York, www.york.com; kitchen cabinets: Gruppo Del Tongo, www.gruppodeltongo.com; kitchen fittings: KWC, www.kwcamerica.com; kitchen fixtures: Blanco, www.blancoamerica.com; lighting fixtures: Venini, www.venini.it; paints/stains/wall finishes: Farrow & Ball, www.farrow-ball.com; refrigerator: Thermador, www.thermador.com; skylights/roof windows: Lane-Aire, www.laneaire.com
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Painless swelling of the feet and ankles is a common problem, especially among older people.
Abnormal buildup of fluid in the ankles, feet, and legs is called edema.
Swelling of the ankles - feet - legs; Ankle swelling; Foot swelling; Leg swelling; Edema - peripheral; Peripheral edema
Painless swelling may affect both legs and may include the calves or even the thighs. Because of the effect of gravity, swelling is particularly noticeable in the lower part of the body.
Foot, leg, and ankle swelling is common with the following situations:
Injury or surgery involving the leg, ankle, or foot can cause swelling. Swelling may also occur after pelvic surgery, especially for cancer.
Long airplane flights or car rides, as well as standing for long periods of time, often lead to some swelling in the feet and ankles.
Swelling may occur in women who take estrogen or during parts of the menstrual cycle. Most women have some swelling during pregnancy. More severe swelling during pregnancy may be a sign of preeclampsia (also called toxemia), a serious condition that includes high blood pressure and swelling.
Swollen legs may be a sign of heart failure , kidney failure , or liver failure . In these conditions, there is too much fluid in the body.
Certain medications may also cause your legs to swell:
Some tips that may help:
Never stop taking any medicines you think may be causing swelling without first talking to your doctor.
Call 911 if:
Call your doctor right away if:
Also call your doctor if self-care measures do not help or swelling gets worse.
Your doctor will take a medical history and do a thorough physical examination, paying special attention to your heart, lungs, abdomen, lymph nodes, legs, and feet.
Your doctor will ask questions like the following:
Diagnostic tests that may be done include the following:
The treatment will be aimed at the cause of the swelling. Diuretics may be prescribed to reduce the swelling, but they can have side effects. Home treatment for benign causes of leg swelling should be tried before drug therapy.
Goldman L. Approach to the patient with possible cardiovascular disease. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 83.
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.
For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.
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Discover the ultimate arcade experience for both casual gamers and pinball lovers alike.
- Enjoy hours of fun in a series of vibrant tables, with new ones available to download from PlayStation Store.
- Cool down the pace with the Slow Motion feature and shoot like a pro.
- Try your hand at a series of single player missions, head-to-head bouts via PlayStation Network and worldwide tournaments.


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Have you ever looked around your home and felt it was just too dark and dreary? A dark room can definitely make you feel down, especially during the winter months. Check out these 5 tips to bring new life to the darkest of rooms.
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Local Articles in Aberdeen
It's the time of year when the winter weather can take a toll. Follow this winter maintenance checklist to protect your home, your car and your health.
If you're experiencing electrical problems in your home or want to add capacity for new projects, consider hiring an electrician for these four services.
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THE Cost of the recessed light is largly determinate on Where ,You purchase the product and the number you buy .Big Box dicount stores have products made oversea's that are less expensive than those found at Custom Bath & Kitchen Stores , but the products are often riddled with problems , missing parts , defects etc,
A typical light will run $ 35.00 to $ 85.00
However , the true cost of recessed lighting is involved in getting circuits or circuity to the switch and lighting system .In NEW construction , this matter is easily dealt with by installing circuits and hardware during framing . Whereas , with remodeling , installing new lighting into existing spaces , requires wall & ceiling opening ,closure , repair , repainting & finishing
I have been involved in projects where the lighting cost but $500.00 ,,
while the installation & finishing costs exceeded $ 2500.00
Here is about the same question (for 1 fan) a while back, with answer:
Your total cost could be from 1.5-3 times that shown in the answer, depending on how much of the wiring for the three fans he can combine - i.e. can he easily run one power circuit for all 3 fans, then just tap off that for switches and runs to the fans, are they fans only or with lights (double the wiring and switches), etc. Note the costs do NOT include drywall/panelling repair or painting to match. Also, you are going to be near the top end of the estimates, because in all probability your access is poor, and 3 fans are almost certain to require a totally new run from the breaker box.
Unless you have an open exposed-joist attic above where the fans are to go AND the top of the walls the switches will go in, you can expect substantial holes in walls and ceiling to pull the wires and fasten them - by code, you cannot just pull wires between joist and let them lie on the top of the ceiling drywall - you have to staple them to joists every few feet, so you end up with several 1-2 foot holes typically near top of the wall (to drill through top plate), near side of ceiling to grab and bend wire coming up wall, and maybe one mid-ceiling to reach in and fasten wire, then of course the two openings that are ultimately fully concealed by the switch plate and the fan mounting plate or dome.
Before you get into this project I would check with the condo management if you are allowed to do this - there are limits to how much you can modify your condo and how much you can modify or add in the way of electric circuits.
Depends a tremendous amount on access - if accessible from exposed-joist in attic above, then you might get this for about $300-500 or so for the wiring and installation, plus $200-400 for the materials and dimmer switches, plus the cost of the light fixtures themselves. Probably about $100-150 to repair ceiling if single hole for one fixture, to $200-300 if existing trough-type flourescent fixtures. Painting the repair could be $100 - 250 depending on whether he can match the patch, or has to repaint the entire ceiling to get a uniform effect - which is more common in kitchens, which usually have untextured ceilings and gloss paint. Another alternative it is have the hole patched and prime and plain paint it yourself, then cover the area with a decorative emblem or crest to avoid having to repaint the whole ceiling. Personally I would just put a compatible style fixture in its place, which you might or might not choose to use, so you avoid the cost of repairing the hole and painting entirely, as that is "lost" $.
If the kitchen/dining room ceiling is not accessible from above, then the electrician will have to tear into wall and ceilings, so installation labor might go to $400-600, and drywall reapir and painting probably to about $400-600, depending on how many holes the elecrtrician has to put in and assuming entire surface painting to get a uniform paint look on each disturbed wall or ceiling.
One possibility for savings might be low voltage lighting for some of the kithcen fixtures, which might reduce your wiring cost and number of holes if you do not have attic access.
Be careful on the dimmable LED bulbs - be aware that dimmable bulbs generally cost a lot more, and many brands don't perform well in dimming mode because they are designed to run at a constant voltage, and a lot will not dim past about 40% power before they flick out or start flickering. Some will actually fry the electronics and burn up at lower voltage. Also, there are three different types of dimmers and different bulbs need a different type dimmer switch, so you will have to be careful to always buy the right type bulb, and use all the same type bulb in a given circuit. Here is an article on the types of problmes you can have with LED dimming, even with bulbs designed to be dimmed -
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Alaska Regional Office PO Box 21628 Juneau, AK 99802-1628 (907) 586-8806
Chugach National Forest 161 East 1st Avenue, Door 8 Anchorage, AK 99501 (907) 743-9500
Tongass National Forest 648 Mission Street Ketchikan, AK 99901 (907) 225-3101
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Release Date: Mar 6, 2015
We are pleased to announce that there are more opportunities than ever before—ten Alaskan wilderness areas hosted by the US Forest Service, National Park Service and US Fish & Wildlife Service will be selecting artists for next summer to be partnered with wilderness experts and engaged in stewardship duties, while residing in a backcountry setting.
In December 2014, Congress passed legislation that finalized the remaining Sealaska allotment under ANCSA, enabling the conveyance of 18 parcels in Southeast Alaska.
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Kan. Senate to take action on NBAF bill
Published on -5/15/2013, 6:51 AM
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TOPEKA, Kan. (AP) -- A bill authorizing Kansas to issue an additional $202 million in bonds for a new biodefense lab in Manhattan is one vote from going to the state House.
The state Senate gave the measure first-round approval Tuesday and was expected to pass it Wednesday.
Gov. Sam Brownback says the bonds will complete the state's financial obligation to the federal government to build the National Bio- and Agro-Defense Facility at Kansas State University.
The lab would research dangerous animal diseases and replace an aging facility on Plum Island, N.Y. Its projected cost has more than doubled to $1.15 billion since Kansas landed it in 2009.
Kansas previously authorized $105 million in bonds for the lab. President Barack Obama's latest budget proposal includes $714 million for the project.


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quote: I think that seals R+L=J
quote:Although I think Sansa is going to reunite with Jon for sure.
quote:I think that seals R+L=J, because I doubt seriously that they would have guessed anything else.
quote:I started reading the Dunk and Egg novellas thanks to you good people.
quote:The end to The Mystery Knight depressed me. Dude refuses to let his readers crack a smile (for more than 90 seconds).
quote:Shierra Seastar
quote:Varys tells Ilyrio that he needs 50 more little birds, but he asks specifically for children who know their letters.
quote:Dunk & Egg saved the day and Bloodraven came at the end. Am I forgetting something?
quote:Which one was it where ya boys brains ran out his helm. I must have gotten the titles confused.
quote:Know their letters so they can read and write
quote:They can get in the small places inside the walls through the secret passages throughout Kings Landing and can listen to what people are saying throughout the castle