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Summary: APOBEC-like N-terminal domain
Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.
This is the Wikipedia entry entitled "APOBEC". More...
APOBEC Edit Wikipedia article
APOBEC-like N-terminal domain | |||||||||
Identifiers | |||||||||
Symbol | APOBEC_N | ||||||||
Pfam | PF08210 | ||||||||
InterPro | IPR013158 | ||||||||
APOBEC-like C-terminal domain | |||||||||
Identifiers | |||||||||
Symbol | APOBEC_C | ||||||||
Pfam | PF05240 | ||||||||
InterPro | IPR007904 | ||||||||
APOBEC ("apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like") is a family of evolutionary conserved proteins.
A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalytic domain. More specifically, the catalytic domain is a zinc dependent cytidine deaminase domain and is essential for cytidine deamination. RNA editing by APOBEC-1 requires homodimerisation and this complex interacts with RNA binding proteins to form the editosome.[2]
Family members[edit]
Human genes encoding members of the APOBEC protein family include:
- APOBEC3D ("APOBEC3E" now refers to this)
- Activation-induced (cytidine) deaminase
A recent review discussed the structural and biophysical aspects of APOBEC3 family enzymes[3] .
- ^ PDB 2NYT; Prochnow, C., Bransteitter, R., Klein, M.G., Goodman, M.F., Chen, X.S. (2007). "The APOBEC-2 crystal structure and functional implications for the deaminase AID.". Nature 445 (7126): 447â451. doi:10.1038/nature05492. PMID 17187054.; rendered using PyMOL.
- ^ Wedekind JE, Dance GS, Sowden MP, Smith HC (April 2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business". Trends Genet. 19 (4): 207â16. doi:10.1016/S0168-9525(03)00054-4. PMID 12683974.
- ^ Jaguva Vasudevan, AA; Smits SH, Höppner A, Häussinger D, Koenig BW, Münk C. (June 2013). "Structural features of antiviral DNA cytidine deaminases". Biol Chem. 394 (11): 1357â1370. doi:10.1515/hsz-2013-0165. PMID 23787464.
This protein-related article is a stub. You can help Wikipedia by expanding it. |
This article incorporates text from the public domain Pfam and InterPro IPR013158
This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.
This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
APOBEC-like N-terminal domain Provide feedback
A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent deaminases domain and is essential for cytidine deamination.APOBEC-3 like members contain two copies of this domain. RNA editing by APOBEC-1 requires homodimerisation and this complex interacts with RNA binding proteins to from the editosome [1] (and references therein). This family also includes the functionally homologous activation induced deaminase (AID), which is essential for the development of antibody diversity in B lymphocytes, and the sea lamprey PmCDA1 and PmCDA2, which are predicted to play an AID-like role in the adaptive immune response of jawless vertebrates [2]. Divergent members of this family are present in various eukaryotes such as Nematostella, C. elegans, Micromonas and Emiliania, and prokaryotes such as Wolbachia and Pseudomonas brassicacearum [3].
Literature references
Wedekind JE, Dance GS, Sowden MP, Smith HC; , Trends Genet 2003;19:207-216.: Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business. PUBMED:12683974 EPMC:12683974
Rogozin IB, Iyer LM, Liang L, Glazko GV, Liston VG, Pavlov YI, Aravind L, Pancer Z;, Nat Immunol. 2007;8:647-656.: Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase. PUBMED:17468760 EPMC:17468760
Iyer LM, Zhang D, Rogozin IB, Aravind L;, Nucleic Acids Res. 2011; [Epub ahead of print]: Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems. PUBMED:21890906 EPMC:21890906
External database links
Pseudofam: | PF08210 |
This tab holds annotation information from the InterPro database.
InterPro entry IPR013158
This domain is found at the N terminus of the Apolipoprotein B mRNA editing enzyme. Apobec-1 catalyzes C to U editing of apolipoprotein B (apoB) mRNA in the mammalian intestine.
The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent deaminases domain and is essential for cytidine deamination. APOBEC-3 like members contain two copies of this domain. This family also includes the functionally homologous activation induced deaminase, which is essential for the development of antibody diversity in B lymphocytes. RNA editing by APOBEC-1 requires homodimerisation and this complex interacts with RNA binding proteins to from the editosome [PUBMED:12683974] (and references therein).
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Molecular function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines (GO:0016814) |
zinc ion binding (GO:0008270) |
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
Loading domain graphics...
Pfam Clan
This family is a member of clan CDA (CL0109), which contains the following 16 members:
A_deamin AICARFT_IMPCHas APOBEC_C APOBEC_N Bd3614-deam dCMP_cyt_deam_1 dCMP_cyt_deam_2 DYW_deaminase LmjF365940-deam MafB19-deam OTT_1508_deam Pput2613-deam SCP1201-deam Toxin-deaminase XOO_2897-deam YwqJ-deaminaseAlignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...
View options
We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (22) |
Full (683) |
Representative proteomes | NCBI (716) |
Meta (0) |
Jalview | ||||||||
PP/heatmap | 1 | |||||||
Pfam viewer |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
Format an alignment
Download options
We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
Seed (22) |
Full (683) |
Representative proteomes | NCBI (716) |
Meta (0) |
Raw Stockholm | ||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
External links
MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Seed source: | Manual |
Previous IDs: | none |
Type: | Domain |
Author: | Finn RD |
Number in seed: | 22 |
Number in full: | 683 |
Average length of the domain: | 172.70 aa |
Average identity of full alignment: | 33 % |
Average coverage of the sequence by the domain: | 80.64 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details: |
Model length: | 188 | ||||||||||||
Family (HMM) version: | 6 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
Sunburst controls
ShowThis visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
Tree controls
HideThe tree shows the occurrence of this domain across different species. More...
Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the APOBEC_N domain has been found. There are 12 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
Loading structure mapping...


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I have the accordion working but I can not get it to display the scroll bar, I need the accordion to be a fixed height, so I would like the scroll bar to work for this. What do I need to do to display it?
Thanks....I got it.
I noticed the link from http://yuilibrary.com/gallery/show/accordion, the "example" link points you to http://ipeychev.github.com/yui3-gallery ... accordion/ instead of http://ipeychev.github.com/yui3-gallery ... index.html. The later shows the "scrollable" hyerlink. |
Both links point to same place, but if you think that was the reason you haven't noticed this example page - no, I just created it.
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The page returns a 404 now. Could you describe what you did to make it scrollable?
Sorry, I updated the link.
thanks. i was looking for this too.
Thanks for the link, no longer 404
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It's more than a year since Hurricane Katrina and its aftermath. The national spotlight on the Crescent City has dimmed, and residents are finding it harder than ever to rebuild their lives. Some have become expatriates in distant cities. The insurance checks that never arrived for homeowners were followed by the bureaucratic nightmare that was the Road Home program, and a land-grab is underway as developers and disaster capitalists press their advantage. Crime and drug use are up, and corruption and graft are endemic, with civic institutions unable to counter any of it.
And yet the culture of New Orleans somehow endures.
While the spirit is alive in New Orleans, its residents are still dealing with loss – of homes, jobs and loved ones. In the wake of her brother's death, Ladonna (Khandi Alexander) helps her mother move out of her old home and upriver to Baton Rouge, while worrying about the increasingly dangerous conditions in the neighborhood. Toni Bernette (Melissa Leo, recent Oscar-winner for The Fighter) helps her daughter, Sofia (India Ennenga), cope with Creighton's death, while still assisting others in finding answers for their own losses. And Albert Lambreaux (Clarke Peters) is forced out of his temporary residence and must make ends meet with a meager insurance check.
In addition, New Orleans civil servants now have to contend with the shocking rise of crime, coupled with the mysterious loss of funds essential to the restoration of the city. Lieutenant Terry Colson (David Morse) is caught in the crossfire, dealing with the current crime wave and still trying to sort out the truth in the wreckage of the past.
TREME's musicians are trying to survive as well, with mixed results. Antoine Batiste (Wendell Pierce) maintains the lifestyle of a musician, despite persistent challenges from his girlfriend Desiree and a lack of funds, and entertains the idea of leading his own band. Yet as the New Orleans school system comes back to life, he also finds himself drawn to the very place where the city's musical culture begins.
Meanwhile, Annie Tee's (Lucia Micarelli) profile is on the rise, while she continues her relationship with DJ Davis McAlary (Steve Zahn), who now has fresh musical ambitions of his own. On the other hand, Annie's ex-boyfriend Sonny (Michiel Huisman) – though presented with a genuine opportunity – must first contend with his own demons. Meanwhile, renowned trumpeter Delmond Lambreaux (Rob Brown) has been joined in New York by chef Janette Desautel (Kim Dickens), both pursuing their careers there, but feeling the tug of their native culture.
"We are following the actual timeline of post-Katrina New Orleans as a means of understanding what happened – and what didn't happen – when an American city suffered a near-death experience," says David Simon. "In doing so, we're trying to address ourselves to what the American experiment has become and what possibilities remain for us.
"We are an urban people now. How we live together – and of what we are capable or incapable of achieving as an urban people is going to define our future," he adds. "New Orleans and its recent history speaks to that."
David Morse (The Hurt Locker; HBO's John Adams) and India Ennenga, both featured in the first season of TREME, become series regulars, along with new cast member Jon Seda (the upcoming Larry Crowne; HBO's The Pacific), playing Nelson Hildago, who arrives fresh from Dallas to avail himself of the unique opportunities that New Orleans could offer some in the wake of Katrina.


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Jerdon 1600 Watt Wall Mount Hair Dryer with Night Light
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SherryNov 4, 2012Link to this post
Otar B.Tbilisi, GeorgiaQueryTo whom it may address,Reply to this post
Pls advise whether Jerdon 1600 Watt Wall Mount Hair Dryer with Night Light is for 220 volt (European voltage) operation. If not pls recommend any alternative for for 220 volt usage.
OtoNov 29, 2011Link to this post
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VIDEO: Heidi Klum Goes Gangnam Style
There have been many spoofs and attempts to top Psy's original Gangnam Style video but nothing has compared to the original. That is until Heidi Klum doned a blue tuxedo and bow tie and joined Psy himself.
This video was shown at the recent MTV European Music Awards and now it has finally shown up on YouTube.
To see the extended version—including a full scene involving airport conveyor belts—head to Heidi's Facebook page.
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Just fix the AHCI already, AMD I've been partial to AMD for a long time. The first PC I built for myself had an Athlon Thunderbird running at a blistering 1.4GHz,... Type: Blog post Tags: Motherboards Chipsets |
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Mayan mysticism
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Mayan Astrology Birth … Read more


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Book Description:Flavia Gemina is brilliant at finding things, so it's natural for her to solve mysteries. The daughter of a ship's captain living in Ostia, the port of Rome, in AD 79, she acquires a gang of three friends who help her. There is Jonathan, the Jewish boy (and secretly a Christian); Nubia, the African slave girl; and Lupus, a mute beggar boy. Together they work out who severed the heads of the watchdogs that guard people's homes, and why he did it. Caroline Lawrence is a terrific storyteller and a delightfully readable and accessible writer with characters that children will relate to. Her picture of daily life in Ancient Rome is wonderfully vivid. But The Thieves of Ostia is first and foremost a whodunnit, with lots of twist and cliffhangers - and a mystery for the reader to solve.
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Dana Atti, Sales Associate
Coldwell Banker West Shell
2721 Erie Ave Cincinnati, OH
Office: (513) 321-9944 , Mobile: (513) 335-6798 , Fax:
2721 Erie Ave Cincinnati, OH
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2721 Erie Ave, Cincinnati, OH 45208
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About Dana Atti
- Commitment to Sellers: Understand your reasons for moving, your time frame and your financial goals Focus on selling your home for the best price and under the terms and conditions that work in your best interest Offer staging consulting included in my service to you Provide thorough competitive market research and work with you to determine the best pricing strategy Listen to you, understand your goals, keep you informed and involved in the entire selling process and what to expect Utilize the latest technology to market and promote your home Aggressively negotiate terms to sell your home that work for you
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- Personal Background: Dana is third generation Realtor, with both parents and grandfather in the business. Dana has lived in Mt. Lookout/Hyde Park since 2006 with her husband and two children. She is an avid lover of HGTV's House Hunters.
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Quality CareFind out why Mayo Clinic is the right place for your health care. Make an appointment.
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October 12, 2011
Support the Occupiers
Dear CODEPINKer,
Feel like cooking up some revolution? Here's our Recipe for Social Change:
Serves: The World
When it comes to our economic priorities, it's time for the people to get a bigger slice of the pie than the Pentagon and the corporate profiteers.
Why not bake an "Occu-pie" for your local action? Choose your favorite recipe from our Peace Never Tasted So Sweet cookbook. Help educate your community on how our tax dollars are spent by also taking the federal budget pie flyer.
If sweet pies aren't your thing, bring (or order) a pizza for your fellow protesters. The famous "Occu-pie" Libretto's created for Occupy Wall Street is 99% cheese, 1% salami, but unfortunately our federal spending pie is 48% war funds that benefit the 1%. Help keep the "Bring Our War $$ Home" message loud and clear at Occupy Together actions nationwide. The best way to pay for our needs at home is to end war.
Haven't joined your local Occupy action yet? October 15 would be a great day to start-people around the world are going to gather in solidarity to initiate global change . Find your local action here. Don't miss out on being part of this historic movement.
Rolling out the pie dough to bring the war dough home, Alli, C.J., Farida, Gayle, Janet, Jodie, Kristen, Lisa, Nancy, Medea, Melanie, Rae, Sanaa, and Tighe
p.s. The Afghanistan war anniversary prompted some powerful actions from our Ground the Drones campaign. CODEPINK was at the forefront of the protests at Creech Air Force Base and the National Air and Space Museum, where protestors, including our own Medea Benjamin, were pepper sprayed . As she reminded us, though, pepper spray is nothing compared to what innocent civilians face when drones rain bombs down on their communities. To find out what you can do to ground the drones, visit our campaign page.


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(CE:852b-853a) DAYR AL-QURQAS. The first and only ancient author who pointed out this monastery was al-MAQRIZI (d. 1441), in his list of the monasteries (1853, Vol. 2, p. 504). He indicated that this monastery was perched on the mountain behind DAYR AL SAB'AT JIBAL (Monastery of Seven Mountains) and that one could reach it only by paths hollowed into the rock. It is three hours' walk between the site and Dayr al-Sab'at Jibal at AKHMIM—that is, Dayr al-Madwid at the entrance of Bir al-'Ayn, east of Akhmim. He noted that a well of fresh water was situated below the monastery, surrounded by "ban" trees (a kind of willow). In 1820, Belzoni (1820, p. 32) heard tell of it. J. A. St. John (1834, p. 277) asked for information about this monastery, but could obtain no confirmation. The most precise information was given by M. JULLIEN. He reported information supplied to him by the inhabitants of Akhmim. Mounting the plateau, one finds a road that goes to the southeast. Following it for three hours' walk, one comes to the remains of a monastery, Dayr Ascaros and Siclavios (Dioscorus and Aesculapius, two martyrs of Akhmim, whose memory is preserved at 1 Tubah in the Coptic recension of the SYNAXARION from Upper Egypt (Basset, PO 18, p. 510; Forget, CSCO 49, p. 362 [text]; 78, p. 295[trans.]). The Synaxarion speaks of a pool to the east of the town; Jullien also spoke of a pool near the monastery (Martin, 1972, pp. 126-27). Unfortunately, there is no description of this monastery or of what may survive of it. RENÉ-GEORGES COQUIN MAURICE MARTIN, S.J.
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Audrey Brooke Suede Paramount Satchel
Sorry, this item is sold out!
Looks like you've got more shoe shopping to do - have fun!
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- Detachable logo keychain
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- Dimensions: 16" x 6" x 11"
- Imported


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WIDE ANGLE was created in 2001 as a response to the lack of in-depth international news coverage in the United States. Seven years later, WIDE ANGLE is the only program exclusively dedicated to international current affairs documentaries. For each broadcast, producers and journalists from around the globe report on an event, issue or trend through the eyes of the people who are living it day to day. In its first five seasons, WIDE ANGLE traveled to more than 50 countries to explore the forces that are shaping the world today, presenting global stories on a human scale and offering Americans uncommon and invaluable insight into today's interconnected world.
Time for School 3 (Part 2)Time for School 3 (Part 1)Eyes of the StormVictory Is Your DutyContestant No. 2The Market MakerBirth of a SurgeonCrossing Heaven's BorderRaise the Last GlassField Trip to the DMZVote for Benazir's BloodYou Cannot Hide from AllahUnderground Zimbabwe: Life LinesFrom Jihad to RehabIraqi ExodusChina PrepLord's Children
Join Mark Breen for a night of stargazing at the Northern Skies Observatory in Peacham.
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Everglades trip teaches environmental appreciation
Huntington, Ind.—Imagine snorkeling among barracudas, lobster, green parrot fish in coral reefs and canoeing near the Gulf of Mexico—and then imagine earning college credit for it. This is exactly the paradise Dr. Jeffrey Webb's "American Environmental History" class experienced during their week-long adventures in the Florida Everglades, while the rest of Huntington University was experiencing record cold temperatures.
The class was designed to give students an in-depth look at major problems in American environmental history in the first week, and then in the week following, they packed up their gear and drove a bus down to the Florida Everglades where they set up camp in Biscayne National Park and began exploring the surrounding wildlife. They spent their days hiking, canoeing, snorkeling and keeping their daily journals. At night, they sat around the campfire and chatted, making new friends and playing guitar. Students enjoyed and captured pictures of the mangroves forests, rare birds, coral and alligators, and the "battlegrounds" of nature conservationalists and the corporations who wanted to build over the Everglades.
"It's amazing what beautiful things God has created on this earth for us to enjoy and how often we take those things for granted and end up disrespecting his glorious creations," said freshman Emily Swartz, a youth ministries major from Syracuse, Ind. "I can't imagine those beautiful structures being covered in tar."
This was the point Webb intended when he put together the class.
"We study the human impact on south Florida," he said, "…but you really don't get a sense of that until you're actually down there."
It began with the Puritans, Webb said, who believed that the wilderness was something devilish that had to be tamed. It wasn't until the 20th century when the transcendentalist movement began to push the United States into once again seeing nature as something beautiful, rather than something to be feared and pushed back from civilization.
"Essentially, they began to realize that you weren't going to lose your spirituality or become less spiritual by going into nature," explained Webb.
"What we find in environmental history," he explained further, "are these episodes that sort of teach us about the human nature…half the class is devoted to introducing creation care."
Students were introduced to the idea of studying Biblical passages on how Christians should take care of the environment. They were assigned an essay on the subject, and their daily journals continually dealt with this issue.
"We were playing with the idea that these little experiences we were having in Georgia and in south Florida could offer to us certain parables that contain wisdom, if we're willing to pay attention," Webb said.
For many of the students, the experience of snorkeling among the fish was among their most treasured memory of untainted wildlife.
"Getting to experience the beauty of the parks we visited… is something that a majority of people may not ever get to do," said sophomore Jacob Rose, an elementary education major from Butler, Ind.
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Police are investigating the discovery of a woman's body found in the trunk of a car at an impound lot near the Minneapolis Farmers Market.
The gold Lexus had been in the Wrecker Services lot, located at Lyndale Ave. and Glenwood Ave., since April 11.
According to the Hennepin County Sheriff's Office, an odor prompted employees of Wrecker Services to open the trunk of the Lexus in which the body was discovered.The car was registered to a St. Paul woman, but St. Paul police said they have no missing person case with her name.The car had been towed from a location in Brooklyn Park, Minn., to the Minneapolis lot. Brooklyn Park police are now involved in the investigation. The death is being investigated as a possible homicide.
WHBQ-TV | Fox 13 485 S. Highland St.Memphis, TN 38111Main Station: (901) 320-1313Newsroom: (901) 320-1340


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I just read the letter (Feb. 11, 2013) from Dorothy Koontz, Howard's mom, and I'm so glad to see that somebody agrees with me about the Bible, and this country being built on the Bible.
What happened that brought this country to the state that's it's in and to the parents who fear for their children in school is when Madeline Murray O'Hare had the Bible taken out of the schools back in the 60s just like Dorothy said. That's when this country started to go down hill.
And as far as punishing children and not allowed to spank them, that's wrong. A swat across the behind, not a beating, once in a while doesn't hurt any kid. And as far as a time out, that doesn't always work. I had a few swats when I grew up, and it didn't hurt me.
What we need to do is try, don't know if it will happen, to get the Bible back in the schools and in the hands of the government and get this country back on the right track.
Look how people respected everybody, property and everybody got along. And if somebody was really down and out, and if they lost a home due to a fire, flood, etc., people would pitch in and give them the shirt off their backs like back in the 50s.
Dottie Gibbon


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There's no substitute for hard work, practice and dedication when it comes to perfecting your fighting prowess, but there's nothing wrong with taking it easy after a hard day at the gym. Wear the American Fighter Fly By tee and maintain that killer attitude of persistence while you go out for a post-training nosh. Not only does the tee feature fearsome American Fighter eagle motif graphics, but it's totally comfortable too, making it an indespensible shirt for your wardrobe. It's important to stay on the top of your game, but also important that you take a break every once in a while.
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Northwestern Washington Travel Guide
News & Features
New at Fodor's
This week, we covered top destinations for great family getaways—from Disney World to dinosaur spotting.... Read more
Arts & Culture, Trip Ideas
Go on location in Görlitz, Germany, to the transporting set of director Wes Anderson's film... Read more
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Hello all! Read more
It is time for me to contribute to Fodor's instead of mostly lurking for information and pictures.
I recently did a 1 day photography whirlwind trip around Seattle...
Please see my Trip report @
http://foods-drinks-travels.blogspot.com/2013/09/sparkling-northwest-city-named-seattle.html Read more
Hey all:
Any suggestions for safest route to take from Grand Rapids, MI to Vancouver, WA at the end of this month (March 2014)? Read more


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yesterday while driving my 1985 astro i heard a small pop under the hood, and then immediately th...
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my mechanic told me the front upper ball joints are worn out and needs to be replaced. cost 671.00.
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Lot 317 Abell Road, Kuching City Center, Kuching, Malaysia 93100 (Show on map)
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Bing (0.2 Km / 3 min walk)
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Sony Vaio VGN-AW31M/H review
With an 18.4-inch screen, this is one serious slab of Sony technology -- and it has a price tag to match. Understated styling and a battery worth the name aren't normally to be found in desktop-replacement laptops, but the Sony Vaio AW31M/H is a versatile machine capable of more than playing Blu-ray movies Read more
21 August 2009 by Julian Prokaza
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HP TouchSmart tx2-1020ea review
Making full use of Vista's tablet PC features, the 12.1-inch TouchSmart tx2-1020ea offers decent performance and a good feature set in an attractive and robust package. It's on the heavy side and its multitouch capability may not be all you'd expect at this price, though Read more
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Dell Latitude XT review
Dell has bided its time before entering the Tablet PC arena, producing its Latitude XT. The result is impressive to look at and is a very usable PC, thanks to its excellent dual-mode touchscreen and keyboard. As usual with Dell products, it has loads of customisation options, too Read more
1 July 2008 by Sandra Vogel
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Panasonic Toughbook CF-W7 review
You don't have to be a builder or work in the desert to own a Panasonic Toughbook CF-W7, but it won't hurt for you to be extremely clumsy. This laptop can withstand considerable crushing forces, is stomp-proof, spill-proof and drop-proof. See if it'll survive the road warrior in you Read more
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Fujitsu Siemens LifeBook S6410 review
The Fujitsu Siemens LifeBook S6410 is a good ultraportable laptop and a joy to use. The keyboard is responsive and ergonomically designed, and it sports plenty of great features, including integrated 3G connectivity and a mounted webcam. With its light, good looks, this laptop won't weigh you down Read more
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Dell XPS M1730 review
Meet 'The Beast' -- Dell's XPS M1730. It's the first laptop ever to use a dedicated Ageia PhysX processing unit alongside two separate high-end graphics cards, making for one incredible gaming experience. Graphics is what this laptop is all about, and it can certainly throw its weight around Read more
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Asus W5Fe review
Asus has a track record of releasing innovative laptops, and its latest endeavour takes advantage of SideShow -- one of Windows Vista's most dramatic new features, which lets you look at pics and listen to music using an external second screen Read more
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CNET UK > Reviews > Computers > Laptops
Dell Latitude D420 review
Dell's seductively small and light laptop, the Latitude D420, is designed for highly mobile users who value size, weight, battery life and durability over all other aspects of computer use. It delivers the added bonus of an integrated 3G data card, enabling users to get online anywhere -- with or without a Wi-Fi hotspot Read more
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Asus A7Tc review
Asus' A7Tc is the first product we've seen that makes full use of a Turion 64 X2 Mobile processor, in this case it's the 2GHz TL-60 chip. This component means double the processing power, allowing the laptop to handle a greater load and run many programs simultaneously. It's certainly not a looker, though Read more
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Motion LE1600 review
The LE1600's carbon-fibre chassis is as corporate as a grey flannel suit, but its sleek design and the powerful performance make for an attractive system. If you're sold on slate-style tablets and can stomach paying around £1,500 for a portable computer without a keyboard, this is the machine for you Read more
1 September 2005 by Don Lipper
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Gimmicks by BKE Pieced Shirt
SALE $40.00 was $52.00 Item #492508629JS161- Pieced lace button front sleeveless shirt
- Chiffon back
- High low hem
- Raw edge details
- Layering piece(s) sold separately
Gimmicks by BKE Pieced Shirt 1 1
Pretty I wore this with a long sleeve blue shirt, a blue polka dot cami on top of that, then the shirt. Had a red, white, & blue scarf & of course, matching bracelets. Super cute outfit. Very versatile, can wear it when it's cool or warm. True to size. Really like it. March 30, 2013
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Robert John Wade
Position: C
Height: 6-5 Weight: 299 lbs.
Born: January 25, 1975 in Harrisonburg, VA
College: Marshall (school history)
Drafted by the Jacksonville Jaguars in the 5th round (148th overall) of the 1998 NFL Draft.
Weighted Career AV (100-95-...): 43 (1912th overall since 1950)
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Lenovo touts energy efficiency, UWB power notebook
Lenovo plans to announce Tuesday that all of its X-, T- and R-series computers with Santa Rosa platforms will qualify for the Energy Star 4.0 rating that goes into effect on July 20.
The Energy Star program, which is overseen by the Environmental Protection Agency and the U.S. Department of Energy, revised its voluntary set of energy efficiency standards for computers for the first time in over a decade. Among the standards required to garner an Energy Star 4.0 sticker is a decreased power consumption while a computer is idle.
Intel's Santa Rosa (Centrino Pro or Intel Duo) platform, which is being touted on many laptops, … Read more


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Team Pro Women |
On-court |
Nickname (if one exists):Mat
Birthdate: 28/04/85
Nationality: French and Swedish Best Ranking (WTA) : 59
Racket: T-Rebound Pro
String (+tension): Black Code 23kgs
Years with Tecnifibre : 1
Best shot:backhand
Favorite player to watch:Federer
Favorite tournament:French Open
Best double partner?
-none I don't really play double Best win/best memory:Pavlyuchenkova/winning my first round in Paris this year Worst loss!/ashamed of…:first round at the french with 8 match points against a qualifier
Except your racket, what's always in your bag?
- my phone,my wallet Your power song in your ipod before entering the court?:Wati house de Section d'Assault Any special ritual before entering the court?:Put my hair band
Off-court |
Main objective in life:Be happy and healthy
Best synonymous for tennis:play
Nothing is better than:going to bed :-)
Favorite website:pinterest.com
Favorite youtube video:Charly beat me
Favorite food:Japanese/Sushi
Favorite quotation:"Quand on veut on peut"
Number of friends on Facebook:361
I could not play tennis without:hair band If you could turn pro in another sport which would it be and why?:Handball If someone walked into your room right now, what would they notice first?:A lot of creme!
You're on a date an trying to impress, where do we go?:For the first date I let the guy decide You've got 2 weeks and a private jet, where do we go?:In sweden first to my 2nd home and then to every nice city in Europe
Top3 reasons to wake-up every morning:turn off the alarm,check Facebook and eating my breakfast How long does it take to get ready in the morning ?!:1h How do you relax?sleeping In a movie about your life, which actor/actress could play you?:Jenna Elfman
Best shopping place?!:Everywhere!But mostly Paris :-) Any advice for other players:Have fun
Its equipments |
Stay tuned |
If you weren't born a top-player, you'll watch this video more than once: http://t.co/7mlN6w2Nki @filippeliwo @LacosteTennis @ATPWorldTour
Latest news |
02 December 2013
Being Official Sponsor of the biggest indoor tennis event is the "cherry on the cake" of our 5-year... Read more
02 October 2013
Tecnifibre, official ball and official stringer in ATP Challenger MONS, Belgium Read more


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3D Vertical Bar Graph provides both client and server-side solutions for the incorporation of bar graphs into Web pages. It provides versatile components so that Web authors and Java developers can easily build and publish dynamic and interactive bar graphs. There are many configurable features and functions to both the applet and servlet and as such, the documentation and examples are designed to give both a full understanding of every feature and enable you to implement both the applet and servlet quickly and easily. The series of examples gives an overview of the variety of implementations possible.
CouchUnit is a JUnit extension that helps administer tests run against CouchDB. It mimics the syntax and feel of DBUnit by helping developers write tests that load XML style datasets to place databases in known states between integration tests. A number of standard operations are used to store and remove CouchDB documents. Any number of documents may be declared within a single CouchUnit dataset.
DDMSence (pronounced "dee-dee-em-Essence") is the only Java library that fully supports the DoD Discovery Metadata Specification (DDMS). It provides a complete implementation of the DDMS specification using any DDMS version between 2.0 and 5.0. Validation is performed according to both the schema and the specification, and custom validation rules can be defined with ISO Schematron.
DaVinci is a comprehensive framework for model-driven Web engineering. It provides an architectural specification, an UML-based modeling framework, and a Java runtime library which is the implementation of the proposed architecture. DaVinci Web applications can be built on top of this architecture using sound models and CASE-tools.
EZMorph is simple Java library for transforming an Object to another Object. It supports transformations for primitives, Objects, and multidimensional arrays, compatibility with JDK 1.3.1, and small memory footprint (~76K). It began life as the converter package in Json-lib but became a project on its own.
Essential Budget a personal finanance manager that fully supports creating and tracking a budget against actual expenses. With a high-quality, cross-platform, professional user interface, it simply performs all of the basic features expected of a personal finance manager, and aims to replace tools like Quicken(tm) for home finance management in the future.


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Reel WorldMore "Stink"—The stink is back by popular demand! Thanks to those four incredible sold-out screenings the other weekend, the Guild Cinema in Nob Hill has decided to resurrect local zombie flick The Stink of Flesh for a special one-night only encore. On midnight, Saturday, Aug. 21, the film will be screened for all those Flesh-hungry zombies who didn't get a seat at the last go-around. This one will probably sell out as well, so get your tickets early. Film ReviewThe Blind Swordsman: ZatoichiUnpredictable hack-and-slash is bloody entertainingAsian action purists who've absorbed a majority of actor Shintarô Katsu's 26 legendary Zatôichi films (a role he played from 1962 to 1989) will probably find filmmaker Takeshi Kitano's recent pop culture-puréed remake a bit too revisionist. In Japan, where Zatoichi is a movie icon on par with James Bond, that's a big deal. Here in America, where you'd be lucky to find one in 50,000 people who've ever even heard of Zatoichi, it's probably not such a major consideration. Film ReviewGarden StateIntimate writing/directing debut is is not your garden variety comedyBut what I really want to do is direct: It's been a lament uttered by overly ambitious actors since the dawn of the motion picture era. Charlie Chaplin did it. Orson Welles did it. Mel Gibson did it. Now Zach Braff, star of NBC's hit comedy "Scrubs," is stepping behind the camera for his multi-hyphenate debut, the indie comedy Garden State. Idiot BoxTV NewsTelevision tidbits from around the DialGreen With Envy?--Immigrants rights groups are protesting the new TV series "Gana La Verde" ("Win the Green"), a "Fear Factor"-inspired reality show contest which claims to give out free green cards to Mexican immigrants wishing to enter the United States. Actually, the show only offers a year's worth of free legal advice to each weekly winner. Still, the groups feel that having contestants sleep with snakes, fend off deadly guard dogs and jump between speeding semis presents a "false impression of how the immigration process works." Despite (or more likely because of) the controversy, the show is currently ranked number two among 19 to 49-year-olds. The show only airs on Spanish language stations in Los Angeles, San Diego, Dallas and Houston. Twenty episodes have aired so far, and several contestants are described by the show's producers as "close" to getting their green cards. |
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Looking east at the Tulsa State Fairgrounds in the 1930s. The fairgrounds is bordered by Louisville on the west, Yale on the east, 15th and 21st Streets on north and south.The new arena building is at the lower left. The International Petroleum Exposition (IPE) complex is on the right. The racetrack and stands are at the top.
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Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance
Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance
Cell Metabolism, Volume 16, Issue 6,
Pages 765-776,
Publication Date 15 November 2012
Copyright © 2012 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.cmet.2012.10.016
Cecile Vernochet
Arnaud Mourier
Olivier Bezy
Yazmin Macotela
Jeremie Boucher
Matthew J. Rardin
Ding An
Kevin Y. Lee
Olga R. Ilkayeva
Cristina M. Zingaretti
Brice Emanuelli
Graham Smyth
Saverio Cinti
Christopher B. Newgard
Bradford W. Gibson
Nils-Göran Larsson
C. Ronald Kahn
Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
Max Planck Institute for Biology of Ageing, Robert-Koch-Strasse 21, 50931 Cologne, Germany
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA
Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27704, USA
Department of Experimental and Clinical Medicine and Diagnostic Electron Microscopy Unit, United Hospitals of Ancona, Ancona 60020, Italy
Adipose Organ Lab, IRCCS San Raffaele Pisana, Rome 00163, Italy
Cardiovascular Metabolic and Endocrine Diseases, Pfizer, 620 Memorial Drive, Cambridge, MA 02139, USA
Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, 76230 Querétaro, Mexico
Corresponding author
► Adipose tissue-specific TFAM KO protects from obesity and insulin resistance ► Adipose tissue-specific TFAM KO increases energy expenditure ► TFAM KO increases mitochondrial uncoupling and decreases complex I activity ► Increased adipose tissue mitochondrial oxidation has positive metabolic effect
Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, but the role for adipose tissue mitochondria in the development of these disorders is currently unknown. To understand the impact of adipose tissue mitochondria on whole-body metabolism, we have generated a mouse model with disruption of the mitochondrial transcription factor A (TFAM) specifically in fat. F-TFKO adipose tissue exhibit decreased mtDNA copy number, altered levels of proteins of the electron transport chain, and perturbed mitochondrial function with decreased complex I activity and greater oxygen consumption and uncoupling. As a result, F-TFKO mice exhibit higher energy expenditure and are protected from age- and diet-induced obesity, insulin resistance, and hepatosteatosis, despite a greater food intake. Thus, TFAM deletion in the adipose tissue increases mitochondrial oxidation that has positive metabolic effects, suggesting that regulation of adipose tissue mitochondria may be a potential therapeutic target for the treatment of obesity.


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Brazil Energy Drinks Category Profile 2013
Report description
A competitively priced comprehensive overview of the Energy Drinks market.
Why was the report written?
Available in over 80 country combinations the 2013 Energy Drinks Category Profile reports provide a comprehensive overview of Energy Drinks markets. Compiled from Canadean's Category Profile series the reports offer a cost effective way of quickly gaining an understanding of the industries dynamics and structure.
What is the current market landscape and what is changing?
Current and emerging trends are highlighted as well as the assumptions for outlook
What are the key drivers behind recent market changes?
The Energy Drinks Category Profiles report series provides an analysis of the drivers behind category performance in the respective markets, covering for example the impact of the economic environment, rising/falling consumer disposable income levels, growing numbers of entrants and Private Label offerings etc
What makes this report unique and essential to read?
The Energy Drinks Category reports 2013 comprises of data tables, charts and supporting text. The reports are compiled from Canadean's extensive global soft drinks databases which are researched individually by country using our specialist researchers 'on the ground'. The Energy Drinks Category Profile reports provide an invaluable guide to latest trends.
Data includes consumption volumes(million litres & litres per capita) from 2007 to 2012 plus forecasts to 2016.
Percentage markets shares are provided including segmentation data, packaging data and distribution 2011 and 2012actuals, plus 2013 forecasts.
Leading companies' market shares for 2010, 2011 and 2012 are provided.
Where applicable, new products in 2012 are identified.
Supporting text includes commentary on current and emerging trends, segmentation, packaging, distribution, pricing/valuation and where applicable, private label.
Table of contents
Note: The content of the Energy Drinks Category Profiles may vary slightly as not all sections are relevant to all countries
Energy Drinks Category Profile
Energy Drinks Key Facts
Chart - Energy Drinks Leading Trademark Owners, 2012
Energy Drinks Commentary
Current and Emerging Trends
Functional Products
Private Label/Private Label Producers
Energy Drinks New Products and Photo Shots
Energy Drinks Data Tables
Energy Drinks Consumption 2007-2013F
Consumption Chart
Annual Incremental Growth Chart
Energy Drinks Consumption Forecast 2013F-2016F
Energy Drinks Segments 2011-2013F
Energy Drinks Packaging 2011-2013F
Energy Drinks Distribution 2011-2013F
Energy Drinks Leading Companies 2011-2012
List of Tables
Table : Brazil Energy Drinks Consumption, 2007-2013F
Table : Brazil Energy Drinks Consumption Forecast, 2014F-2016F
Table : Brazil Energy Drinks Segments, 2011-2013F
Table : Brazil Energy Drinks Packaging, 2011-2013F
Table : Brazil Energy Drinks Distribution, 2011-2013F
Table : Brazil Energy Drinks Leading Companies, 2010-2012
List of Figures
Figure : Brazil Energy Drinks Leading Trademark Owners & Private Label, 2012
Figure : Brazil Energy Drinks Consumption and Growth Chart, 2007-2016F
Related research categories
By sector: Energy (in Soft drinks), General drinks
By market: Brazil (in South America), Brazil (in BRICM)
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Publication: theday.com
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In a nearly seven-month deployment, the crew visited ports in Haifa, Israel; Bahrain; Jebel Ali, United Arab Emirates and Lisbon, Portugal. The USS Toledo was deployed to the European Command area of responsibility on a maritime and national security operations.
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