This paper presents the results of different numerical analyses (nonlinear dynamic FEM simulations) regarding the monumental buildings in Ripabottoni village (Campobasso, southern Italy), which were damaged by the 2002 Molise earthquake. In particular, the church of S. Maria Assunta, for which typological data and an exhaustive damage survey are available, is taken into account. Some preliminary studies [Spallarossa et al., 2004], which correlate the waveform of the available recordings from aftershocks and the surveyed damage mechanism (due to the crushing of the vertical structural elements), suggested that a feasible explanation for this particular damage pattern does not involve only the intrinsic vulnerability of this type of buildings, but deals also with the high energy content in the high frequency range observed in the vertical component of the seismic events. In order to understand the structural damage patterns surveyed, synthetic accelerograms, representative of the main shock (M l —5.4 on 31 October 2002), were computed. The Empirical Green Function (EGF) method was applied to compute the seismic input adopted in the nonlinear dynamic analyses that we performed for the church of S. Maria Assunta. The results confirm that the observed damage pattern cannot totally be put down to the vulnerability of the building, but the particular characteristics of the seismic action played a fundamental role in determining it.


Background: Performing cholecystectomy concomitant to laparoscopic sleeve gastrectomy (LSG) in morbidly obese patients with asymptomatic cholelithiasis is poorly discussed. Objectives: We conducted the current investigation to compare concomitant to late cholecystectomy in asymptomatic gall stone patients undergoing LSG. Patients and methods: One hundred morbid obese patients scheduled for LSG were included in this retrospective analysis. They were divided into two groups: Group 1 included patients who underwent concomitant cholecystectomy, and group 2 that included patients who omitted such a procedure. Delayed cholecystectomy was scheduled if the patient developed symptoms related to gall bladder disease. The incidence of post-operative complications and percentage of developing symptomatic cholelithiasis in group 2 were our outcomes. Results: All preoperative data were statistically comparable between the two groups. However, operative time and intraoperative blood loss were significantly increased in group 1. The incidence of total early post-operative complications also increased in the same group (14% vs 0% in the other group). In Group 1, we encountered two patients with intraperitoneal bleeding (4%) who required laparoscopic management, in addition to the other two cases with biliary leakage (4%). In group 2, 18% of patients expressed symptomatic gall stone disease before the scheduled operation, while two cases (4%) developed acute complications that required early cholecystectomy. Conclusion: Cholecystectomy is associated with an increased incidence of early post-operative complications when performed in association with LSG. However, about 25% of asymptomatic cases who omitted the concomitant procedure will develop symptoms before the scheduled cholecystectomy.


Accumulation of reactive oxygen species and inflammation are major features of diabetic vasculopathy, yet the underlying mechanisms remain elusive. Long non-coding RNAs (lncRNAs) are emerging as important players in the pathogenesis of cardiovascular disease. Recent work has shown that PANDA, a newly identified lncRNA, is a key regulator of cellular senescence and apoptosis.

 To investigate the role of lncRNA PANDA in diabetic vascular disease.

 Human aortic endothelial cells (HAECs) were exposed to normal (NG, 5 mmol/L) and high glucose concentrations (HG, 25 mmol/L). PANDA depletion in HG-treated HAECs was obtained by siRNA transfection while a scrambled RNA was used as a negative control. Expression of PANDA was assessed by real time PCR. PANDA RNA immuno-precipitation (RIP) was performed to check its binding to relevant transcriptional factors (NF-YA). Beta-galactosidase staining was used to detect endothelial senescence while, migration and tube formation were employed to evaluate angiogenic properties of HAECs. Finally, RNAs sequencing (RNA-seq) and bioinformatic analysis (network perturbation amplitude, NPA) were leveraged to unveil transcriptional changes upon PANDA depletion. Finally, the ex vivo effect of PANDA siRNA on endothelial function was assessed in aortic rings from diabetic mice.

 PANDA expression was significantly increased in HAECs exposed to HG as compared to NG (Fig. 1A). We found that under HG conditions PANDA sequesters the transcription factor NF-YA, thus inhibiting the expression of NF-YA-dependent pro-survival and anti-aging genes (Fig. 1B). Indeed, silencing of PANDA in HG-treated HAECs restored the expression of anti-apoptotic genes Bcl-X(L) and Bcl-2 while blunting senescence-related genes such as p53 and p16INK (Fig. 1C). PANDA depletion also abolished HG-induced cellular apoptosis and senescence, as assessed by caspase-3 activity assay and b-gal staining (Fig. 1D-E), while improving endothelial migration and tube formation (Fig.1F-G). Transcriptomic analysis revealed dysregulation of several genes upon PANDA silencing with the antioxidant gene heme oxygenase-1 (HMOX1) as the top-ranking transcript in HG-treated cells (Fig.1H). NPA analysis showed a strong involvement of PANDA in senescence, DNA damage, NRF2 signaling, hypoxic stress response and proliferation (Fig. 1I). Of interest, PANDA levels were increased in aortas from diabetic mice (Fig. 2A) while depletion of PANDA rescued endothelial dysfunction (Fig. 2B).

 Hyperglycemia-induced upregulation of PANDA drives endothelial senescence while impairing angiogenic properties. PANDA depletion in HG-treated HAECs rescues maladaptive transcriptional changes by restoring expression of the antioxidant gene HMOX1. Of note, targeting PANDA in the diabetic vasculature was able to rescue endothelial dysfunction. Our results indicate PANDA as a novel molecular target in the setting of diabetic vascular disease.


We investigate the device performance of heterojunction graphene nanoribbons tunneling field-effect transistors as a function of the doping concentrations based on the non-equilibrium Green's function. We observe that variation in source doping changes the OFF-state currents (IOFF), the ON-state currents (ION) and the subthreshold slope (SS) significantly while variation in drain doping changes mainly the IOFF. Additionally, low SS and large ION/IOFF ratio can be achieved by applying proper asymmetric source-drain doping.


The paper examines the experiences of parents of deaf and hard of hearing children related to the decision-making process about the cochlear implant, as well as their satisfaction with the outcomes of cochlear implantation. The research was carried out on the sample of 77 examinees of both sexes whose children are rehabilitated at "Children's House" at the Clinical Hospital Centre in Belgrade, as well at schools for deaf and hard of hearing children in Kragujevac, Subotica and Nis. The questionnaire entitled Children with Cochlear Implants: Parental Perspectives was used for the purpose of the research. The results of the research indicate that parents had moderate difficulties in the process of deciding on cochlear implantation and that they were relatively satisfied with the outcome of the implantation. The age of children and the age at which the cochlear implantation has been performed are not related to the process of deciding on cochlear implantation, although this variable correlates with the contentment with the outcome of the implantation.


ABSTRACT Glaciers in the Pamir are the water tower of arid Central Asia, and more than 50 million people depend on meltwater from them. Many studies have reported glacier changes in the Pamir, but the glacier inventories employed in the previous investigations are both outdated and lack comparability. In this study, we present a new multitemporal glacier inventory for the Pamir based primarily on the Landsat ETM+/OLI scenes from the period around 2000 and 2017. Glacier outlines in 2000 and 2017 were delineated manually using Landsat images, SRTM digital elevation model (DEM), and high-resolution Google Earth images, using the same criteria and methods. We mapped 12,186 glaciers covering 10,396.20 ± 421.16 km2 in 2017 for the Pamir and demonstrated that the Pamir lost 124.28 ± 81.33 km2 of its glacier areas with a shrinkage rate of 1.17 ± 0.77 percent or 0.07 ± 0.05 percent·a−1 from 2000 to 2017. Based on the new inventories and the existing elevation change data sets of High Mountain Asia (HMA) from 2000 to 2016, we calculated a weaker glacier mass loss of −0.05 ± 0.06 m w.e. a−1. Spatial heterogeneity of glacier changes has been found in both the area and mass balance, but our results still suggest that the Pamir glaciers changed slightly since 2000.


Species of Peucedanum (sect. Peucedanum) with closer botanical relationships were source of taxonomic, ecologic and coenologic incertitudes. Coenological studies of grassland vegetation in the Carpathian basin completed with the ecological indicators contributed to the foundation some coeno-ecological species groups, which can express and characterize the coenological differentiation of the Peucedanum-species and stands. Thus, various stands of P. officinale are characterized by distinctive group of species for dry, humid and semi-dry salt meadows, P. longifolium by groups for rupicolous submediterranean habitats, P. rochelianum by a group of fen and wet meadows, P. tauricum by a group of xerothermic fringe vegetation and an other for stepic grasslands. It is presented the vegetation structure, local diagnostics, constant and dominant species of recently described plant community: Inulo ensifoliae-Peucedanetum tauricae.


The article sets out to examine the way the Hararghe Oromo in Ethiopia use their mirriiysa culture to express and cultivate criticality, mindfulness, interpersonal sensitivity and emotional intelligence. The paper discusses the nature of the performance culture and analyses the social psychological meanings of a set of mirriiysa texts collected from a group of folk performers who participated also in the interpretation and analysis of the cultural, social and psychological meanings of the texts. For theory, the study drew on interpretivism. During data analysis, the horizontal and vertical planes of analysis interacted and reinforced each other. The act of removing earwax symbolizes a cultural dimension of intersubjectivity and interaffectivity. The analyses indicated that mirriiysa is a socio-cultural performance wherein listening, understanding and responding occur in socially meaningful and interactive contexts. To understand the communicative intent of a mirriiysa text, one should take broader perspectives and pay due attention to the non-linguistic elements that offer the performance holistic import. The paper highlights the implication of these and other findings for our understanding of the meanings of mirriiysa and other genre performances.


Objective To study the anti-hypoxia effect of eucommia polysaccharide in mice,in order to provide the theory basis for further development and use of eucommia. Methods Mice were given orally with different dosages of eucommia polysaccharide continuously for 7 days.1 hour after the last administration,the anti-anoxia action under normal-pressure,acute cerebral ischemia anoxia test and the hemorrhagic shock experiment were carried out.The survival time,the breath after the halt of whole brain blood supply and the heart-beat were observed. Results 10.9 g polysaccharides were gained from 500 g of eucommias crudes.The results showed that eucommia polysaccharide prolonged the survival time,maintained the breath and the heart-beats after the whole brain blood supply stopped. Conclusion The eucommia polysaccharide may protect against hypoxia in mice.


Abstract A study of the effects of two component compatibilizers, epoxidized natural rubber (ENR) and ethylene-co-acrylic acid copolymer (EAA) on curing characteristics, mechanical properties, swelling behavior, and morphology of silica-filled natural rubber (NR)/recycle rubber powder (RRP) blends was carried out. Results indicate that the presence of ENR/EAA has reduced the cure time, t 90, improved processability, and increased cross-link density of the silica-filled NR/RRP blends. The mechanical properties such as tensile strength, tensile modulus, and hardness were also enhanced with the presence of ENR/EAA. The improvement of mechanical properties was due to the higher cross-link density and better interaction between silica and NR/RRP blends with the presence of ENR/EAA as two component compatibilizers.


The magnetic field strength around electromagnetic valve must be decreased from 2000 Gs to 50 Gs to ensure the electromagnetic valve work well in ITER project.Magnetic shielding under 2000 Gs was computed through finite element method.The comparison between computed results and the experiment results are listed in the article.The results indicate that the material with high saturation magnetization work well in strong magnetic field.The results also indicate that the orientation of magnetic field influences the magnetic shielding performance.When the orientation of magnetic field is perpendicular to the axis of magnetic tube,the magnetic shielding performance can be better.


In Europe induction is becoming a very important phase of teacher training, but still little is said about its limitations and pitfalls. The purpose of this paper is twofold. First, it analyzes both a series of limitations and pitfalls encountered in the implementation of the induction process. Second, it identifi es precautions that need to be taken into consideration when implementing such programmes, in order to determine some opportunities of improving the induction process. With the intention of achieving the purpose stated above, we used a case study approach to investigate the Estonian induction programme that has been implemented since 2004. We have chosen this case because it is recognized in Europe as one of the best induction programmes and it bears a resemblance to the Romanian educational system. The results of our study point to a number of problems that arise in various aspects regarding mentors, newly qualifi ed teachers, school culture and a university approach. Taking those problems into account, we will propose how they could be remedied.


Attention was first called to this stone collar in the following lines of an article on Porto Rico Stone Collars and Tripointed Idols:1 "Sometimes the projection is feruled, often with pits like eyes, and in one collar the prominence is said to have the form of a snake's head." To this is added the following note: "This specimen is owned by Mr Leopold B. Strube of Arecibo, who has sent the author a drawing which shows the knob in the form of a snake's head." This reference was later quoted in the writer's memoir on the Aborigines of Porto Rico.2 On a recent visit to Europe the author examined the specimen, now in Bremen,3 and made the drawings reproduced in figures 97-Ioo. A glance at the first of these shows that it belongs to the type called by the late Professor O. T. Mason4 the "righthanded variety of the slender oval group." This collar is made of a hard, light-gray andesite or diorite, with surface fairly smooth but not finely polished. Its general form is not unlike other examples of the slender ovate type. The special differences are found in the ornamentation of the decorated panel border and the modification of the projection or knob into an animal head. It measures 15 and II inches in greater and lesser diameters respectively.


patients showed clinical hematuria. On these 5 patients, 1 patient showed bladder involvement on cystoscopy (17%), while the others showed no bladder involvement on cystoscopy (83%). Whether for the remain 1 patient with clinical non-hematuria, cystoscopy shows no bladder involvement. On the other hand, ultrasound shows bladder involvement clearly in all these 6 patients (100%). (EP34.30). Ultrasonography versus histopathology for diagnosing cervical cancer metastasis to urinary bladder, which one is more accurate? Andi Darma Putra, MD, Oncology Division, Obstetric & Gynecology Departement Cipto Mangunkusumo Hospital, Jakarta


Thank you for downloading a companion to organizational anthropology. Maybe you have knowledge that, people have look numerous times for their chosen readings like this a companion to organizational anthropology, but end up in malicious downloads. Rather than reading a good book with a cup of tea in the afternoon, instead they are facing with some malicious virus inside their desktop computer. a companion to organizational anthropology is available in our digital library an online access to it is set as public so you can get it instantly. Our book servers spans in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the a companion to organizational anthropology is universally compatible with any devices to read.


Unbalanced Development among different regions challenges the sustainable development of media online.Lack of Competitive advantage results from a series of reasons,such as smaller scale of population and people online,less developed economic performance.Competitive situation is construed in the regional media online market.The causes of lack of competitive advantage are discovered and presented.The competitive strategy that should be taken is put forward.


Georgia's elite is more interested in modernizing the country than democratizing it. They sought to achieve
a society transformation, restore the country's territorial unity, and modernize it all at once. However, the
August 2008 war with Russia has exhausted the leadership and undermined its key accomplishments – establishing
effective state institutions and securing public confidence in them. The regime is now ready to go
back on its previous reforms in order remain in power. To this end, it has even sought to improve relations
with the Georgian Orthodox church.


While the Great War raged, Australians were twice asked to vote on the question of military conscription for overseas service. The recourse to popular referendum on such an issue at such a time was without precedent anywhere in the world. The campaigns precipitated mass mobilisation, bitter argument, a split in the Labor Party, and the fall of a government. The defeat of the proposals was hailed by some as a victory of democracy over militarism, mourned by others as an expression of political disloyalty or a symptom of failed self-government.


This paper introduces a framework called the COOL framework for developing server-side software components or complete systems for online courses. The framework has been designed to eliminate the limitations facing the integration of commercial web-based course delivery software and in-house pedagogical innovations on the server end. With the adoption of the framework, complete server systems can allow third-party software components to be incorporated into and pedagogical innovations can be re-used to their full potential. The COOL framework provides a middle layer 'wrapper' that exposes the server-side components as URLs, which can be accessible to any web delivery system. The framework is being adopted in a number of projects.


— Locating masterpieces by Muslim philosophers in the field of philosophy is a challenge for several reasons: the interconnectedness between human knowledge as a discipline, and that this theme cannot be innovative. In addition, in order to understand the roots of philosophy within the Arab cultural environment and its development it is necessary to examine the history of Arab culture. Arab culture can trace its origins back thousands of years to the Mesopotamian, Pharaonic, and Saba and Himyar Civilizations. Although these civilizations witnessed the birth of streams of thought that can be considered philosophy, the word philosophy itself was not used because it is a Greek word. Despite the fact that philosophy dates to Ancient Greece, it is considered modern in comparison with the civilizations of Mesopotamia and Pharaonic Egypt. Thus, it is more accurate to refer to the beliefs developed by these civilizations as thought and not philosophy. Indeed, the word philosophy only came to be applied to Arab culture with the arrival of Al Kindi (801- 870 CE). When examining the use of the term philosophy in the context of Arab culture, we will determine the meaning of the word and explain how it was defined in ancient times; specifically, whether the sources that Muslim philosophers relied upon were Greek or other sources. This paper comprises only an introduction, describing the multiple approaches and the achievements conferred upon Muslim philosophers. It will take the form of an encyclopedia style entry to establish a foundation for researchers wishing to explore the achievements of Muslim philosophers.


The appropriate combination of a luminophore and a binder for Pressure-Sensitive Paint (PSP) for a cryogenic wind tunnel has been investigated. The sensitivity of a PSP is governed by the luminescence lifetime of a luminophore, the oxygen permeability of a binder and the oxygen
partial pressure in a test gas. Test conditions in cryogenic wind tunnels (oxygen concentrations: 0.1% or less, temperatures: 100 – 180 K) are greatly different from those in "warm" wind tunnels (oxygen concentrations: 21%, temperatures: 300-330 K). Therefore, PSPs for a cryogenic wind
tunnel demand severe requirements for a luminophore and a binder. In this paper, we studied the necessary conditions of PSP for cryogenic wind tunnels and evaluated them experimentally.


When we think of Australia's visual arts engagement with Asia, we tend to focus on short-term projects, be they exhibitions, biennales, festivals or commissions. Such events have undoubtedly been significant in raising the profile of Asian art in Australia, in sending Australian art and artists to our region, and in building people-to-people connections. Their visibility has given us a sense of engagement and promoted a feeling of pride in Australia's early recognition of Asian contemporary art. Yet they can also potentially mask a lack of depth in this engagement. What happens in between these events? Do they fundamentally shift our perspective and transform our institutions? Can they make an impact on the artists themselves? After all, ongoing connections are difficult to maintain, structures and outlooks are hard to change, and short-term projects have the potential to stand in for the hard graft of deeper research, sustained collaboration or more diverse programming.


Recently, expert systems have been used in different fields for different purposes in order to respond to the changing user needs with the rapid development of information and communication technologies. The most important of these can be listed as interpretation, prediction, diagnosis, design, planning, imaging, debugging, maintenance, education and control. With the increase in the use of expert systems in the field of healthcare, expert systems are not only used for diagnosis and treatment, but also act as a decision support system. Today, there are many software and approaches for nutrition program planning on the basis of nutrition-oriented practices. In particular, rule-based or case-based expert systems are frequently used in the field of nutrition.
The aim of the research is to develop a web-based expert system prototype in the field of nutrition with a rule-based system approach using the Prolog development environment. For this purpose, because of clear and neat syntax, one of the expert system programming languages based on "first order predicate calculus" that is Prolog, PHP for web and in the design phase; Bootstrap framework were preferred. For data visualization, data is retrieved from MySQL database. The application developed within the scope of the research is expected to contribute to the efficient implementation of nutrition planning, especially for institutions with insufficient human experts.


The clinical value and costs of different diagnostic tools used to identify potentially curable recurrent disease in patients treated adjuvantly for curatively resected Dukes' C colonic cancer were examined.


Carboniferous rocks from North Karakorum display sharp lateral variations in lithology and thickness suggesting accumulation in half-grabens during continental rifting between the Karakorum block and northern Gondwana. Different Carboniferous successions, belonging to distinct tectonic units, have been detected. Thin, poorly fossiliferous successions of arenites and crinoidal limestones contrast with very thick terrigenous-carbonate successions comprising two distinct fossiliferous horizons. The lower fossiliferous horizon yielded brachiopods ( Pustula sp., Rhipidomella sp., Choristites sp., Martiniopsis sp., Afghanospirifer sp., Gypospirifer sp., Composita sp.) of Bashkirian age. The upper fossiliferous horizon, lying about 90 m above the former, contains corals, crinoids and brachiopods ( Densepustula cf. losarensis , Dowhatania sulcata n. sp., Brachythyris sp., Rhipidomella sp., Septacamera dowhatensis , A lispirifer middlemissi ) of Moscovian to Kasimovian age. The Carboniferous brachiopods of North Karakorum are similar to those collected in the Late Carboniferous of Central Afghanistan, Himalaya (Manang, Spiti, Tibet), and Lhasa Block (Xainza area).


In sheep, the gastrosplenic and mesenteric veins converge at an angle of about 140° to form the portal vein, which is joined, along its right ventral border, by the gastroduodenal vein. At the porta, right and left branches of the portal vein diverge at an angle of 65–70° to supply separate areas that join along a line between the fossa for the gall bladder, and the middle of the left branch. Right dorsal branches leave the portal vein or its right branch near the point of bifurcation.

When 131I-albumin that had been heated was injected into the right ruminal vein and entered the portal stream in the gastrosplenic vein, no significant differences existed in the levels of radioactivity between the areas supplied by the different portal branches. When the 131I-albumin entered the portal stream from either the gastroduodenal or mesenteric veins, the area supplied by the right branch contained a significantly higher level of radioactivity than the remainder of the liver. When corrections were made for an unequal distribution of blood, it was found that blood from the gastrosplenic vein was distributed preferentially to the left branch, blood from the gastroduodenal vein to the right branch, and that blood from the mesenteric vein enters the right and left branches in preference to the right dorsal branches of the portal vein.


The character of local exchange has long assumed an important place in the historiographical debate on the capitalist transformation of the American countryside. Whereas that character has been carefully examined in nearly every rural corner of the United States, it is poorly understood in the context of early agricultural California. Based on a systematic analysis of the diaries of one California farmer, this essay explores the everyday, local exchange practices of ordinary farmers, especially among neighbors. It finds farmers relying on one another extensively for a wide range of goods and services and maintaining dealings that assumed both commercial and non-commercial characteristics. It argues, moreover, that such findings reinforce criticisms of how scholars have traditionally defined early California's rural economy and that they challenge some of the dominant paradigms in rural American historiography that characterize the nineteenth-century economy either in essential terms or in terms of an uneasy coexistence of ambivalent systems.


Results: Using standard statistical methods together with pathway and net- work analysis, we identified a set of 319 features displaying significantly different levels between patients and controls; these features highlight 31 pathways that are potentially deregulated in psychotic patients. Based on these relevant features, we used the topology to explore relations among the biochemical and clinical data defining the profiles of patients. In particular, we identify subgroups of patients with distinct biochemical characteristics. Conclusion: Altogether, these results highlight biomarkers of early psycho- sis that are biologically relevant, as they are linked to metabolic pathways previously associated with SZ. Importantly, topological analysis of these markers clusters psychiatric patients into subgroups, a significant first step towards biotyping based on patients' metabolic signature. , Background: Epigenetic dysregulation may be involved in the underly- ing molecular deficits in schizophrenia (SZ). Previous research by our group has show hypermethylation of GABAergic promoter gene in and increases in DNMT1 and DNMT3A in post mortem brain samples of patients with SZ. We have also shown that difference sin DNMT1 and other epigenetically related enzymes are also found in the lymphocytes of living patients with chronic schizophrenia (CSZ). We now report pre- liminary results on epigenetic related mRNA's in lymphocytes on a larger sample of CSZ. Methods: CSZ ( n = 29) and nonpsychotic controls (NPC) ( n = 31) subjects had a blood sample (60–80 cc) drawn, and lymphocyte pellet extracted by Ficoll gradient procedure. qPCR assays were used to measure epigeneti- cally mRNA's—DNMT1, DMNT3A, TET1, TET2, TET3, BDNF, (glucocorticoid receptor).We also assayed several immunological related mRNA (which strong hits from sequence analysis) T-Cell Surface Glycoprotein CD4, CCR1 (C-C motif recep- FPRL3 (Formyl Peptide Receptor). Assays were performed using B-Actin as housekeeping gene. with for with Sniff Sticks smell test. were related to poorer cognitive performance and higher levels of immunological related mRNA to greater positive symptom scores. Some potential differences to our previously published results may be related to in mRNA's mea- sured by the Taqman probes and earlier research with specifically generated sequence probes. Background: Current literature suggests that the pathology of schizophre- nia (SCZ) has developmental origins based on mounting evidence show-ing genetic abnormalities and prenatal factors contributing to the early onset of the illness. Nonetheless, there are progressive neurodegenerative processes in this illness that cannot be solely explicated by the neurodevel- opmental theory of SCZ. In addition, numerous animal studies showed that antipsychotics elicit neuroprotective effects by lowering beta-amyloid (A β ) levels. Methods: Focusing on beta-amyloid (A β ) as a measure of neurodegenera- tive changes, a systemic review and meta-analysis investigating A β in SCZ and the link between antipsychotic usage and A β was conducted. A lit- erature search using PsychINFO, Medline and Embase was carried out, examining studies that compared A β between patients with SCZ and com- parison groups. Results: Among 14 identified studies, there were 11 studies comparing A β between SCZ and elderly controls, and 7 studies comparing A β between SCZ and AD. Meta-analysis showed that A β levels did not differ in patients with SCZ from controls. Patients with SCZ showed attenuated level of A β in comparison to patients with AD. Subsequently, only 1 of 5 studies in the Background: Altered peripheral levels of some amino acids (eg, glycine and D-serine) have previously been reported to play a role in schizophrenia. However, the elucidation of the role of amino acids in the pathophysiology of schizophrenia requires a powerful statistical approach by analyzing a set of amino acids to provide a good fit, taking into account their interactive behaviors. Thus, we utilized structural equation modeling (SEM) for the analyses of peripheral amino acid levels. Methods: Fifty-one patients with schizophrenia (males, 31; age, 52.6 ± 10.0) and 37 normal controls (males, 17; age, 50.2 ± 10.2) were recruited between 2010 and 2014. All patients were treated at Dokkyo Medical University Hospital, Hospital, or Shimotsuga General Hospital. The patients were assessed by 2 independent psychiatrists using the DSM-IV-TR crite-ria; control subjects were confirmed to be free of mental illness. The sever- ity of illness was evaluated using the Positive and Negative Syndrome Scale. The peripheral plasma levels of glutamate, glutamine, 2 enantiomers of ser- ine (L-serine, D-serine), glycine, histidine, aspartate, asparagine, threonine, alanine, proline, valine, leucine, and isoleucine were measured using high- performance liquid chromatography. To adjust the interactive effects of a set of amino acids, age, sex, and smoking status, SEM was conducted for all participants to investigate whether individual amino acid phases account for the diagnosis of schizophrenia. In addition, SEM was conducted to determine the relationship between the severity of schizophrenia and concentration of each amino acid, in which the same factors were adjusted. The study was approved by the ethics committee of the Dokkyo Medical University School of Medicine. Results: SEM revealed that the concentrations of glycine, L-serine, aspar- agine, leucine, isoleucine, and threonine significantly accounted for the diagnosis of schizophrenia. Furthermore, the use of SEM to test the relationship of the severity of schizophrenia and concentration of amino acids demonstrates that glycine is related to positive and negative PANSS scores. Conclusion: SEM proved to be a suitable and powerful method to evalu- ate the interactive effects of a set of amino acids and showed that some key amino acids are involved in the pathophysiology of schizophrenia. However, some factors that could affect the system were not involved in this analysis. To obtain more accurate results, detailed examination is warranted. Background: Premorbid social deficits and depression are robust risk fac- tors for schizophrenia-spectrum disorders. Few prospective childhood cohort studies have examined specific aspects of social and emotional func- tioning in those who later develop psychosis. Methods: The current study consisted of participants from the Pittsburgh Girls Study (PGS), a longitudinal study of 4 age cohorts of girls ini-tially aged 5–8 years who have completed annual assessments for the past 15 years. At the most recent assessment, PGS participants were ages 19–22, well within the typical age range for developing symptoms of schizophrenia-spectrum disorders. Of the 2450 families participating in the PGS, 2117 completed the schizophrenia subscale of the Adult Symptom Inventory-4 at the most recent annual assessment; of these, 194 self-reported high psychosis scores (ie, 2 SDs above the mean). It was hypoth- esized that high-psychosis women, compared to low-psychosis women, would have a history of endorsing more emotional and social dysfunction during late childhood on a battery of instruments that measured social skills, perception of peer relations, emotional and asocial temperament, depressive symptoms, and feelings of loneliness (Social Skills Rating System: parent- and child-report, Loneliness and Social Dissatisfaction Scale: child-report, Emotionality, Activity, and Sociability Temperament Survey: parent- and teacher-report, and the Child Symptom Inventory-4: parent- and child-report). Results: Consistent with hypotheses, as compared with adults with low psy- chosis ratings, those adults with high psychosis ratings had higher ratings of social and emotional functioning deficits, including lower social skills, more loneliness/social dissatisfaction, asociality, depression, and emotion-ality during childhood. All findings were consistent across parent, teacher and child reports, with the exception of parents, but not teachers, reporting greater asociality, t (2016) = −2.85, P < .01. Conclusion: The current study adds to the literature by prospectively doc- umenting evidence of greater childhood deficits in social and emotional domains among women who later report atypically high psychotic symp- toms. The specific mechanisms by which childhood social withdrawal, emotion dysregulation, poor peer relationships, and social skills deficits increase vulnerability to psychosis remain unclear. Further longitudinal study of childhood social and emotional functioning is needed to further (1) investigate the developmental progression and emergence of psychotic symptoms, and (2) identify early developmental targets for preventive intervention. Background: Research on "clinically at risk" (CHR) youths has thrived in the last decade, producing important findings on vulnerabilities to psychosis and opportunities for late phase of of in and have of risk indicators the in


The C oxidation reaction on Pt{110}(1×2) has been investigated using molecular beam techniques. The reaction products are CO and CO2. As the surface temperature is increased from 550 to 750 K, the proportion of CO2 produced decreases from ∼50% to <1%. When oxygen first impinges on the surface, the formation rate of CO is observed to rise immediately (⩽0.1 s), and then rise more slowly to a maximum before decreasing sharply as the C adlayer is depleted. The production of CO2 is initiated after a measurable delay. Angle-resolved product distribution measurements demonstrate that CO desorbs in a sharp lobe centered at an angle of 32° to the surface normal, fitted to cosn(θ−32), where n=50±5. The C oxidation reaction site is identified with the (111) microfacets. It is concluded that two processes are operative, a Langmuir–Hinshelwood mechanism and a reaction in which CO is impulsively desorbed.


In a previous paper (1932) we have described experiments indicating that in an intact frog muscle the metabolism is increased between 2 and 3 times when the air surrounding the muscle is replaced by a mixture of 21 per cent 02 and 79 per cent CO. The purpose of the present paper is to extend these observations to other tissues of both cold and warm-blooded animals and to show that this increased metabolism is not merely an increase in the normal metabolism but rather a CO metabolism in which CO is burned to CO2 by the consumption of oxygen. The important fact emerges from these experiments that it is only in muscle tissue, either heart or skeletal, that this stimulation of metabolism or the burning of CO can take place to any important extent. The significance of this fact is not at present clear. SERIES I. THE EFFECT OF CO ON DIFFERENT TISSUES. Method: The general technique employed for the oxygen consumption measurements of series 1 has already been described. For the particular experiments herein reported it may be stated that two differential volumeters are used in which are placed two comparable pieces of tissue. In one respirometer is put a mixture of 02 and CO containing 21 per cent 02 and, in the other, air. The oxygen tension is therefore the same in both and is adequate to meet the demands of the tissue. Oxygen consumption measurements are then made for 2 to 3 hours after which the gases in the two respirometers are interchanged. The oxygen consumption rates are again measured for a similar period of time. At least 1 hour is allowed before the final rates are obtained which are used in tabulating the results. In muscle t)here seems to be no after effect due to the period of CO so it seems permissible to average together the two rates so obtained in CO for comparison with the two rates obtained in air. Thus instrumental errors and random differences between the two samples are ruled out. The experiments were all carried on at 22°C. on frog, turtle, and rat tissues. The frogs were Rana pipiens or R. clamitans and the turtles most,ly Pseudomys elegans. ResuZts. By means of the technique described we have made measure-


Work-function modulation in a reconfigurable field-effect transistor (RFET) is investigated by 3-D TCAD simulations. A significant work-function dependence is found in the critical electrical performances of RFET. The results show that the ON-state drive current <inline-formula> <tex-math notation="LaTeX">${I}_{ \mathrm{\scriptscriptstyle ON}}$ </tex-math></inline-formula> is mainly dominated by the control gate (CG) and source work function, while the OFF-state leakage current <inline-formula> <tex-math notation="LaTeX">${I}_{ \mathrm{\scriptscriptstyle OFF}}$ </tex-math></inline-formula> is dominated by program gate and drain work function. With the work-function regulation, more flexible electrical characteristics among both n- and p-type configurations can be obtained, and an RFET with strict symmetric ON-state current and <inline-formula> <tex-math notation="LaTeX">${I}_{ \mathrm{\scriptscriptstyle ON}}/{I}_{ \mathrm{\scriptscriptstyle OFF}}$ </tex-math></inline-formula> ratio, that is, (<inline-formula> <tex-math notation="LaTeX">${I}_{ \mathrm{\scriptscriptstyle ON}}{)}_{\text {n}}:{(}{I}_{ \mathrm{\scriptscriptstyle ON}}{)}_{\text {p}} = {(}I_{ \mathrm{\scriptscriptstyle OFF}}{)}_{\text {n}}:{(}{I}_{ \mathrm{\scriptscriptstyle OFF}}{)}_{\text {p}} = {1}:{1}$ </tex-math></inline-formula>, has been realized in this work. The underlying physical mechanism is explored, and the corresponding performance of the application in logic and memory is discussed. Moreover, the work-function regulation in CG and source can be recognized as an effective method to subtle tweak noise margin of electrical systems.


This paper reported the experiment of biogas batch fermentation with goat dung under the average temperature 22.9 ℃.The result shows that the potential of biogas production is 214.47 mL/gTS when its TS of fermentative materials is 8.65%.


Newly-promoted Undergraduate universities refer to those that have been formed after the junior college promotes since 1998,Career development of its teacher,which should follow universal law of career development of teacher of university,be restricted by its special law even more,must dispel illusion want which exists in teacher's career development,must transform personnel management pattern for human resources development pattern,promote the teacher's overall development.


Extending the bandwidth of validity of FEM models used in vibroacoustic design is a generic objective of model generation processes. Achieving this objective requires a critical review of both testing and modeling processes. Using the case study of an engine cradle, tools used to detect modal test inconsistencies are first illustrated. On the modeling side, weld spots and lines and variations of thickness due to press forming are shown to have relatively minor impact when compared to the contact surfaces. Usual junction simplifications are also shown to play a major role particularly at higher frequencies where more localized modeshapes occur.


The challenge of tackling the problem of coping with work related stress in a National Health Service (NHS) Trust was undertaken. Ideas were developed within the context of two different action learning sets and led to actions resulting in a large therapy Taster Session event and the establishment of a centre offering alternative therapies and related services for hospital personnel. The key steps taken and the responses of hospital staff who received these services is presented. The role of action learning in bringing about these changes is explained.


Von Willebrand disease (VWD) is caused by quantitative and/or qualitative defects of the von Willebrand factor (VWF), a multimeric high molecular weight glycoprotein. Typically it affects the primary hemostatic system, which is reflected by a mucocutaneous bleeding tendency simulating a platelet function defect. VWD is the most common inherited coagulation disorder. The current classification comprises the main types 1, 2 and 3. The qualitative type 2 variants are differentiated into the subtypes 2A, 2B, 2M and 2M. Among these, type 2A is very heterogeneous, consisting of several phenotypically different disease entities with the diagnostic hallmark of a loss of the large multimers. Up to now, the quantitative type 1 variants were considered the most prevalent with frequencies of 70% to 80%, compared to type 2 (15-25%) and type 3 (<5%). Phenotypic characterisation of our patients was done by a battery of tests that included VWF:AG, VWF:CB, VWF:FVIIIB, the RIPA-test, and multimer analysis combined with luminescent visualisation of the electrophoretic bands by means of a sensitive video system. Among 634 patients with inherited VWD, studied during 2003, 51% had VWD type 1 compared to 47% with type 1 and 2% with type 3. Most of the type 2 variants were type 2A (75%), while type 2M (16%), type 2B (6%) and type 2N (3%) were infrequent. Thus, many patients with presumed VWD type 1 and bleeding symptoms have VWD type 2 instead. The diagnosis of VWD type 2A subtypes depends on a standardised multimer analysis as the critical method.


Through them the theme of loneliness and communication difficulties is uppermost. Not that the characters in these plays are ever at a loss for words — rather that they have lost the ability to communicate with each other, or that they use language for other purposes: such as to comfort themselves, as the middle-aged Viktoria, who suspects her husband of having an affair, in Ingmar Bergman's prize winning play for radio. Or they use language in an overtly witty and sadistic fashion to hurt, as the couple Sarah and David demonstrate with enormous deftness in Lars Noren's so-called 'comedy about love' where the stakes they are playing for are their own human dignity. Lars Noren has been compared to Strindberg in his numerous biting satires about bourgeois married life. Language follows the formula for the 'theatre of the absurd' in Stig Larsson's play, in which a number of pairs of strangers attempt to make some form of contact with each other at a pedestrian crossing to no avail. Although one recognizes many 'speech game' patterns in their semantic endeavours, the 'cause-and-effect' dialectic is totally absent and they part bewildered and upset. Lack of mutual understanding seems to be the theme of Summer Nights which takes up many of the problems of contemporary life, where egocentric couples intent on pursuing their own careers, fail to give each other the time, understanding nor love they so desparately need. Many contemporary issues are brought to the surface mainly that of daring to love completely and selflessly. Whilst none of these issues is new or innovative in any way, and the stage directions would indicate a conventional staging, it is all the more surprizing that, by way of introduction, Anderman gives an overview of the contemporary Swedish theatre. This excellent summary ranges from the emergence of the modern theatre at the end of the last century with Strindberg's controversial plays, to the present day, touching on major events and personalities, both in Sweden and abroad, visits from innovative theatre directors such as Max Reinhardt, examining the inter-war and the post war years, the emergence of Swedish drama, the Ibsen-Strindberg tradition, and the socio-political trends of the sixties as well as insights into the different Swedish theatrical organizations. Her intention to offer this background as a 'frame of reference' for understanding the plays and themes taken up in this volume is a good one, as that long-awaited Swedish Theatre History book is just in its planning stages.


The utility model provides an infusion bottle with a spherical inner stopper and relates to the technical field of medical supplies. The infusion bottle comprises a infusion bottle part and a spherical inner stopper, wherein the spherical inner stopper is arranged inside the infusion bottle, a bottle bottom opening is formed at the bottom of infusion bottle, an exhaust pipe is arranged in the bottle bottom opening, a seal cover is arranged on the exhaust pipe, and a pull ring is arranged on the seal cover. During infusion, the seal cover is pulled apart from the exhaust pipe, and the infusion bottle is put upside down, so that the mouth of the exhaust pipe with air filtering function faces up and communicates with the external air, and the spherical inner stopper floats on the surface of the liquid inside the infusion bottle. During infusion, the spherical inner stopper drops with the drop of the liquid level. When the infusion is completed, the spherical inner stopper drops to the neck of the infusion bottle to completely block the bottle neck, so as to prevent air from entering the infusion bottle through the bottle neck and thus to effectively prevent air from entering a human body and blood return as well. The infusion bottle with the spherical inner stopper can not only effectively prevent air from entering a human body and blood return as well but also has a simple structure and is convenient to use.


The impact of atmospheric turbulence on sound propagation is an important consideration for source localization with acoustic sensor arrays, studies of noise pollution, and the development of new remote sensing techniques. This paper takes as a starting point a recently derived, closed-form equation for the spatial-temporal coherence function of a broadband acoustic signal propagating in a refractive, turbulent atmosphere with spatial-temporal fluctuations in temperature and wind velocity. The theory is quite general and enables analysis of many statistical characteristics of the sound field. It has certain advantages in comparison with Monte-Carlo simulations and has already been used to study the spatial-temporal coherence of narrowband signals. In the present paper, this theory is employed to calculate and analyze the frequency decorrelation of broadband acoustic signals for different regimes of the atmospheric surface layer. The results are then used to study the effect of atmospheric turbulence on th...


This study addresses the subgrid-scale
 modeling issue for large eddy simulation of shock wave / boundary layer interaction. By
 using a reference flow database, obtained by direct numerical simulation, a priori
 testing of the most prominent LES models is carried out. The various modelling and
 filtering approaches are discussed and compared, leading to suggest a priori the most
 appropriate closure strategy.


ABSTRACT We examine how managerial sentiment affects non-generally accepted accounting principles (non-GAAP) earnings disclosure. Following recent studies, we use terrorist attacks in the US to measure the exogenous shocks to managerial sentiment. We find that (1) firms located in the attacked metropolitan areas are less likely to report non-GAAP earnings; (2) there is a significant decline in non-GAAP exclusions for affected firms, indicating more conservative non-GAAP earnings disclosure; (3) the effect of pessimistic sentiment on non-GAAP earnings disclosure is more pronounced when terrorist-attack events are perceived as more salient, and when managers are less experienced. Our main findings are robust to a battery of robustness tests. Overall, results of this study suggest that shocks induced by exogenous negative events affect managerial sentiment and corporate disclosure practice.


In the present work the effects of hydro cooling on the quality of 'Chimarrita' and 'Chiripa' peaches were evaluated. Peaches were hydrocooled by immersion in water at 5oC with flesh temperatures monitored for 3 minutes and thereafter stored at 0oC ('Chiripa') or 0,5oC ('Chimarrita') for 7, 14 or 21 days. Samples were evaluated at harvest, after retrieval from cold storage and after 2 or 3 more days at 20oC for ripening. Hydrocooled peaches dehydrated more, but both, hydrocooled and control peaches showed symptoms of shriveling after ripening at 20oC. Decay losses of both cultivars did not differ amongst treatments during storage, though, were higher in 'Chimarrita' control peaches after ripening at 20°C. Flesh firmness was similar in hydrocooled and not hydrocooled 'Chimarrita' peaches, but was higher in hydrocooled 'Chiripa' peaches during storage. In both cultivars flesh firmness decreased to the same values after ripening at 20oC. After 21 days of cold storage, woolliness was observed in 50% of 'Chiripa' and in 15% of 'Chimarrita' hydro cooled and not hydrocooled peaches. Firmness retention was observed in 20% of 'Chiripa' and in 50% of 'Chimarrita' peaches. Index terms: Stone fruits, pre cooling, cold storage, chilling injuries.


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At low forces, adhesion lifetimes increase with increasing force.

Zhu/MacmillanNot content simply with a good fit, evolution has apparently designed adhesion molecules that stick optimally only when tugged upon. This property, say Bryan Marshall and Cheng Zhu (Georgia


We present some fundamental flexibility properties for minimum length networks (known as Steiner minimum trees) interconnecting a given set of points in an environment in which edge segments are restricted to λ uniformly oriented directions. These networks are referred to as λ‐SMTs. They promise to play an increasingly important role in the future of optimal wire routing in VLSI physical design, particularly for the next generation of VLSI circuits. In this article we develop the concept of a flexibility polygon for a λ‐SMT, which is a region representing the union of all λ‐SMTs with the same topology on a given set of points. We show that this polygon can be constructed, for a given point set and given topology, in linear time. We discuss some of the future applications of this polygon, which can be thought of as a geometric representation of the amount of flexibility inherent in a given λ‐SMT. © 2005 Wiley Periodicals, Inc. NETWORKS, Vol. 46(3), 142–153 2005


This student directly met the challenge of having her classmates assigned to the psychiatric unit where her mother was a patient.


Category: Trauma Introduction/Purpose: Gunshot wounds are common injuries encountered by orthopaedists in urban settings. Retained missiles can lead to significant morbidity and functional impairment. Despite the potential for adverse sequelae, controversy remains regarding the role of routine bullet removal. Suggested indications for bullet removal include those leading to infection and lead toxicity. Bullets located in the palm of the hand, sole of the foot, or intraarticularly are commonly removed as well. Given the unlikeliness of a retained missile sparing the many joints or sole of the foot, we question the indications for conservative management. The purpose of this case series of is to further develop indications for bullet removal from the foot. Methods: A medical record search was performed at a single one trauma institution, with high volume of patients with ballistic injury, for patients who underwent bulletectomy from 2008 until 2018. Of the 169 patients originally obtained, 17 patients underwent bulletectomy, with associated irrigation and debridement, of the foot and ankle. The record of each patient in this retrospective case series was individually reviewed for location of retained missile, indications for removal, whether the procedure was performed at the bedside or in the operating room, concomitant injuries or surgeries, and follow up. Results: Of the 17 patients with retained bullets removed from the foot and ankle, four (23.5%) were removed at the bedside versus the operating room. Indications for removal were painful palpable subcutaneous position of the bullet (11 or 64.7%), periarticular or intraarticular bullet (five or 29.4%), and infected wound with removal of foreign body to optimize healing (one or 5.9%). The location of the palpable missiles included three on the plantar foot, four on the dorsal foot, and four located in subcutaneous tissues adjacent to the ankle joint. Nine out of seventeen (52.9%) had fractures associated with the retained missile. Of the patients with OR procedure (13), the majority of them (nine or 69.2%) were in the operating room for another procedure as well. Conclusion: The indications for bulletectomy of the foot and ankle are not definite, however, it is recommended that bullets located in the weightbearing plantar foot or intraarticularly be removed. After analysis of a seventeen patient retrospective case series, we support these indications but also advocate for the removal of any painful subcutaneous or periarticular bullet, whether under local anesthesia or in the operating room. In our experience, the prominent foot and ankle bullet is often removed during a procedure for another anatomic site. Bulletectomy of the foot and ankle in a stable polytrauma patient should be considered.


triguing, they nevertheless permit only a partial view of the overall process by which policy was determined. Many important questions still cannot be definitively answered and must be treated with inferences and theories, lacking full release of governmental papers. Given these circumstances, Eva-Marie Cs&ky has put together an excellent and thought-provoking work based on a thorough familiarity with the documents and careful craftsmanship in selecting and editing them. The usefulness of the book is greatly enhanced by an ample, detailed index, by careful citation of the original sources, and by scholarly introductory essays. For those who wish to do further research in the topic, it is an indispensable starting-point. For the general reader it provides a fundamental acquaintance with the essential issues and conditions of Austrian statehood today. Michigan State University RICHARD R. LAURENCE


Lysine is the first limiting essential amino acid for optimal nutritional quality in rice grain. Somaclonal variation was the source of mutation in our breeding program. Biochemical selection was conducted using 1 mM S-(2-aminoethyl) cysteine followed by 5 mM lysine plus threonine in the callus subculture medium. The lysine content in the endosperm of all progenies regenerated from the surviving calli was higher than that of their donor cultivars. These elevated lysine levels of mutants were successfully transmitted to the M 4 generation. Absorbance at 570 nm in the ninhydrin color test was significantly correlated with lysine content and the composition of rice endosperm.


Determining opportunities for geothermal energy can involve a significant investment in data collection and analysis. Analysts within a variety of industry and research domains collect and use these data; however, determining the existence and availability of data needed for a specific analysis activity can be challenging and represents one of the initial barriers to geothermal development [2]. This paper describes the motivating factors involved in designing and building the Geothermal Prospector application, how it can be used to reduce risks and costs related to geothermal exploration, and where it fits within the larger collection of tools that is the National Geothermal Data System (NGDS) [5].


After the first report by Millington et al.,1 the development of electrospray tandem mass spectrometry (MS/MS) has enabled in recent years the introduction of expanded newborn screening programs in many countries.2,3 This has led to an increase in the capacity to detect rare metabolic disorders during the neonatal period. The increase of the only C4-acylcarnitine, as detected by tandem mass spectrometry in newborn screening, is reported to be related to short chain acyl-CoA dehydrogenase (SCAD) deficiency (butyrylcarnitine) or isobutyryl-CoA dehydrogenase (IBD) deficiency (isobutyrylcarnitine).4 Expanded Newborn Screening Pilot Program using MS/MS is being conducted in three provinces of Tuscany since January 2001, and, being officially mandated by a legislative action, screens all babies born in Tuscany since November 2004 (approximately 30 000/year) for selected acylcarnitines and amino acids. We report on a newborn in which the screening showed an isolated apparent elevation of C4-acylcarnitine usually associated with SCAD or IBD deficiency. A careful evaluation of the results and the subsequent biochemical investigations allowed us to demonstrate that this alteration was due to accumulation of formiminoglutamate (FIGLU). Acylcarnitines and amino acids in all dried blood spots from newborn were analysed as butyl esters with the same methodology described by la Marca et al.5 An Applied Biosystems-Sciex (Toronto, Canada) API 4000 triplequadrupole mass spectrometer equipped with a Turbo V-Spray source was employed. MS and MS/MS spectra were collected in continuous flow mode by connecting the infusion pump directly to the Turbo V-Spray source. A standard solution of 1 ng/μl of each amino acid and acylcarnitine in water : acetonitrile (30 : 70) containing 0.05% formic acid was infused at 5 μl/ min. Measurements on samples were performed by using a Series 1100 Agilent Technologies (Waldbronn, Germany) CapPump coupled to an Agilent Micro ALS autosampler, both fully controlled from the API 4000 data system. Experimental flow rate was 70 μl/ min using water : acetonitrile (30 : 70) containing 0.05% formic acid. The eluent from the column was directed to the Turbo V-Spray probe. The acquired data were processed using the Analyst 1.4.1 proprietary software including the 'Explore' option (for spectral interpretation) and the ChemoView software (for quantitative information generation). The child was born from consanguineous Pakistani parents (first cousins) after five uneventful pregnancy. The family history was unremarkable: two brothers and two sisters were normal. The delivery was made by caesarean section because of foetal distress at the 36th week of gestation. At birth, the APGAR score was 9I and 10V, weight 2700 g, length 49 cm, and head circumference 33 cm. Since the first days of life, the infant presented poor sucking and brought up milk. Expanded newborn screening for metabolic diseases by tandem mass spectrometry showed levels of C4-acylcarnitine mildly increased (using a cutoff value of the mean C 2SDs). The physical examination at 20 days of life showed normal cardiac, respiratory and abdominal findings and no dysmorphic features. Increased tendon reflex and mild axial hypotonia with hypertonia of legs were present. EEG showed diffuse paroxystic activity. Abdominal and cerebral ultrasound investigations as well as brain auditory–evoked potentials (BAEPs) and visual-evoked potentials (VEPs) were normal. Fundus oculi, ECG and cardiac ultrasound were normal. Laboratory investigations revealed normocytic anaemia (Hb 10,9, MCV 80,1 fl). Plasma and


Abstract The synthesis and structural characterization of a tetrazine-based catecholamide (CAM) ligand, N,N′-bis(N″-(aminoethyl)-2,3-bis(hydroxy)benzamide)-1,2,4,5-tetrazine-3,6-diamine (5), were investigated. All compounds were characterized by 1H NMR spectroscopy, 13C NMR spectroscopy, and FTIR spectroscopy. The protonation equilibria of 5 and complexation capacities (log βpqr) of Cd2+, Co2+, and Cu2+ complexes of 5 were evaluated through potentiometric titration and spectrophotometric titration, respectively. Species independent pM value (=−log [M]free) was used to compare metal affinities with the final sequence Cu2+ > Cd2+ > Co2+. Results show that 5 has potential for heavy metal removal.


A new metal-free method for theN-quinolylation of primary amino groups using novel dihydrooxazolo[3,2-a]quinoliniums showing good compatibility with other reactive moieties.


Predation plays a crucial role in shaping community structure and can initiate trophic cascades that can alter abundances across adjacent trophic levels. Recent research has suggested that variation among individual predators may have stronger effects on ecological dynamics than previously appreciated. Intraspecific variation within predators could lead to differential levels of top-down control with implications for trophic cascade strength. In this experiment, we manipulated the body size variation of predatory mole salamanders (Ambystoma talpoideum) within experimental mesocosms and monitored a suite of abiotic and biotic response variables. We predicted that predator populations with increased body size variation would have limited top-down control due to weaker interactions with a greater number of prey species. Conversely, we predicted that populations with similarly sized predators would have strong control over fewer prey species. Salamander presence affected nearly every biotic parameter measured, suppressing some populations (e.g. invertebrate predators) and facilitating others (e.g. invertebrate collectors), triggering multiple trophic cascades. A few invertebrate taxa responded to variation in predator body size and in nearly all of these instances, taxa responded more strongly to treatments with increased body size variation than in treatments with similarly-sized predators. Predator size variation may promote individual dietary specialization by differently sized predators, resulting in strong control of focal prey. These results demonstrate that predators have pervasive effects on all trophic levels of a community regardless of size structure, and that when size structure has an effect on abundances of particular taxa, increased body size variation can lead to stronger top-


Through the outline of constitute and features of the number control machine, the article analyzes the common breakdown of the number control system, expounds diagnosis and maintenance to the system and some items which should be noticed in detail.


When poets manipulate and blend categorical language and imagery through the use of metaphor, they change the reality within the poetic work. The purpose of this paper is to extend on the already occurring argument in regards to the role of nature and metaphor in literary works. This paper will demonstrate how images of nature work as tools of social validation for ostracized lifestyles and racial groups. Within the frame of a comparative analysis of John Donne's "The Bait" and "The Primrose" and Langston Hughes' "Dreams" and "Dream Variation" this argument focuses on the way metaphors turn towards nature for purity and then include people within the newly constructed natural image. Questions that are developed and answered are (a) How is metaphor used as a tool of social validation? (b) How can images of nature increase persuasiveness and influence social acceptance? and (c) How has the use of nature evolved over poetic history? What is nature? What laws define and conceptualize nature? These are questions that scholars often ask themselves. Today's media has become hypersensitive regarding nature and often highlights laws that attempt to protect the environment, to social concerns over the o-zone layer and depleting fossil fuels. Nature has been depicted in every art form since the beginning of civilization, from cave drawings, architecture, oral tales, and later poetry. Some of the most popular poetic forms, such as Haiku, Pastoral and Sonnets are dependent on nature as the center image within the form. The question then remains: Why are so many writers drawn to nature in their writing, and what purpose does images of nature serve in poetic works? It is not coincidental that the words "Naturalism" "Naturalized" and "Natural" are all founded on the word "Nature." Nature, uncorrupted by man or any outside force is believed to be pure, and within language writers often seek to attach man-made societies to nature. For this reason, throughout American literary history you will find rural and city poets evoking the offspring of nature, such as birds and trees. The purpose of this paper is to demonstrate the power of metaphor inherent in its ability to empower "outsiders." In order to analyze how Langston


This paper presents, for the first time, an optical-to-mm-wave modulator SoC with an integrated 850-nm wavelength optical receiver front-end for short-range backhaul connectivity in emerging fiber-wireless mobile networks. Realized in 65-nm CMOS, the optical front-end achieves -3dBm optical input sensitivity at 4Gb/s with 10-12 BER. The modulator directly up-converts the de-multiplexed 2Gb/s I/Q NRZ data to a 4Gb/s QPSK signal at 60GHz. The SoC consumes 78mW and produces -7.2dBm output power with -12dB EVM at a bit efficiency of 19.6pJ/b.


Determining cell death mechanisms occurring in patient and animal tissues is a longstanding goal that requires suitable biomarkers and accurate quantification. However, effective methods remain elusive. To develop more powerful and unbiased analytic frameworks, we developed a machine learning approach for automated cell death classification. Image sets were collected of HT-1080 fibrosarcoma cells undergoing ferroptosis or apoptosis and stained with an anti-transferrin receptor 1 (TfR1) antibody, together with nuclear and F-actin staining. Features were extracted using high-content-analysis software, and a classifier was constructed by fitting a multinomial logistic lasso regression model to the data. The prediction accuracy of the classifier within three classes (control, ferroptosis, apoptosis) was 93%. Thus, TfR1 staining, combined with nuclear and F-actin staining, can reliably detect both apoptotic and ferroptotis cells when cell features are analyzed in an unbiased manner using machine learning, providing a method for unbiased analysis of modes of cell death.


The Graduation Thesis is based on the analysis of judicial procedures for real property evidencing at the territory of SMA regional office Slovenj Gradec. At the beginning there is a short theoretical introduction, which presents the legislation of real property recording under judicial procedure. We have analyzed a number of changes in the land cadastre database based on judicial procedures by years. We have discovered that there were only a few evidenced cases from year 1923 to the 1970s, but then the number increases constantly with a few drops and reaches maximum in year 2010. In the first part we also focus on the analysis of duration of judicial procedures based on documentation of the archives in which we discover that judicial procedures in average take approximately three months. In the second part we performed statistic analysis, of a correlation between the number of judicial cadastral points (in second part between the number of judicial procedures) and land use for each cadastral community at the territory of SMA office Slovenj Gradec. The results of regression analysis and Student t-test show that we cannot conclude that there exists correlation between the number of judicial cadastral points and share of building area, fields and forest. In the case of the number of judicial procedures in correlation with land use we can conclude that there is a weak correlation with building area. In the last part we have presented judicial clarification of boundary based on selected cases analyses- we presented selected cases based on the duration and contents.


Objective To explore MRI manifestations,thyrotropic stimulating hormone(TSH) and thyrotropin receptor antibody(TRAb) levels in clinical active Graves ophthalmopathy.Methods 64 patients with Graves ophthalmopathy were performed with orbital MRI scan and clinical activity score test,including 56 active and 8 inactive(control group).Images of extraocular muscles,serum TSH and TRAb were compared between two groups.Results In active group,extraocular muscles manifest edema signal,high intensity signal in fat saturation T2WI images.Furthermore,active group had significantly higher TSH,lower TRAb than control group.Conclusion Edema signal in extraocular muscles,high levels of TSH indicates active Graves ophthalmopathy.


It is crucial to learn which factors could influence the income status of a region. In our study we try to collect basic data which well-represent the chosen topic, and more importantly, which are easy to access and are interpretable on smaller (for example settlement) territorial levels. Based on our hypothesis the received subsidies, the taxes paid by local people and the gross value added generated by local enterprises show strong correlation with the formation of the income status, and this hypothesis was tested for cities and towns in this paper.


The Advanced Photo-injector Experiment (APEX) at the Lawrence Berkeley National Laboratory (LBNL) is an injector system designed to demonstrate the capability of a normal conducting 186 MHz RF electron gun operating in CW mode to deliver the brightness required by X-ray FEL applications operating at MHz repetition rate, such as LCLS-II. A 240 kV, 1.3 GHz CW buncher cavity design was developed as part of the APEX experiment. The two-cell cavity profile has been optimized to minimize the RF power requirements and to remove multipacting resonances over the full range of operation. In order to excite the cavity stably at pi-mode and remove the dipolelike coupler kick, the two cells are independently driven by four, 2.5 kW, coaxial resonant loop couplers with integrated ceramic RF windows and a matching section in the body of the coupler. The coupler's inner conductor has a single diameter change at a specified distance from the ceramic insulator in order to cancel the wave reflected from the ceramic window, thus comprising the coupler matching section. The details of the RF analysis, mechanical design, fabrication and testing of the coupler are presented here.


The attitude of tolerance toward the native otherness and the representation of the Tupinamba "convertible" with docility found in Claude d'Abbeville'sHistoire de la Mission... en l'isle de Maragnan (1614) are clearly tributary of Jean de Lery'sHistoire d'un voyage fait en la terre du Bresil (1578). The capuchin paraphrases the huguenot in several passages, presenting the Indian as an object of "ethnographical" analysis, without excluding him - as Lery does - of the possibility of salvation. Thus, Claude d'Abbeville probably answers to the expectations of the French public in a context of exhortation of the colonisation of Maranhao and promotion of the apostolic work of the Capuchin Order.


Research purposes to improve the ability of reasoning and learning outcomes of students in solving mathematical problems through learning methods Group Investigation for class X Multimedia B SMK Negeri 9 Surakarta. his research is a class act that consisted of 3 cycles. Data collection methods used, namely, observation, field notes, and documentation. The results showed an increase in the ability of reasoning and student learning outcomes that can be seen from the indicators - indicators include: 1) Students submit ideas in the form of a mathematical sentence before the action of 0%, in the first cycle reached 9.68%, while the second cycle reaches 24.14 %, and after the third cycle the action of 40%, 2) students using the formula correctly before actions 29.03%, in the first cycle reaches 48.39%, while the second cycle reaches 65.52%, and after the third cycle the action of 80%, 3) The ability of the students perform arithmetic operations correctly before actions 29.03%, in the first cycle reaches 35.48%, while the second cycle reaches 58.62%, and after the third act cycle to 70%, 4) Value of students above the KKM ≥ 67 before action is 32.26%, in the first cycle reaches 64.52%, while the second cycle reaches 72.41%, and after the third cycle actions 83.33%. It can be concluded that the application of learning methods Group Investigation can improve reasoning skills and student learning outcomes.


The aim of the anesthetic depth monitoring changes with the development of anesthetic techniques,and neurophysio- logical monitoring has been focused gain.Among parameters extracted from EEG signals,such as BIS,AEP,entropy,PSA,and CSI, only BIS had been investigated through multicenters and heavy samples.Although BIS monitoring can reduce the probability of aware- ness,its application has still some limitations.At present,none of parameters can reflect all effects of anesthesia.Thus,the optimal monitor of depth will be one that integrates multiparameters sensitive to different anesthetic effects.


It is important for animals to survive until sexual maturation. For most animals, it is plausible that offspring mortality is high because of their small body size, incomplete physical abilities, and vulnerability to disease. However, evidence is quite limited because it is difficult to observe the offspring of wild mammals immediately after parturition (Gaillard et al. 1997). Meanwhile, some mammals have developed sexual dimorphisms related to mortality and consequent differences in demographic parameters. Cervids are one example, with longevity and mortality pattern often differing between the sexes (Clutton-Brock et al. 1982a). It is therefore necessary to determine the mortalities of males and females separately. Unfortunately, such information is limited (but see Gaillard et al. 1997). From a life history perspective, it is important to investigate the mortality pattern of offspring and to determine which factors affect it. Offspring mortality is also important in terms of lifetime reproductive success (Clutton-Brock 1988; Gaillard et al. 1997) because if an offspring dies before sexual maturity, that offspring is not counted as a "success" in the calculation of the mother's lifetime reproductive success. In fact, CluttonBrock et al. (1982a) regarded only two year old deer (not one year olds) as survivors. If one year old deer are included as survivors when calculating lifetime reproductive success, the result would differ greatly and would be incorrect. It is therefore quite important to track the mortality of offspring for as long as possible. We have studied variations in the lifetime reproductive success of sika deer, Cervus nippon, in relation to individual characteristics for approximately 20 years (Minami 2008; Minami et al. 2009a, 2009b, 2009c). We have shown that high mortality was concentrated during the period of immaturity in both males and females (Minami 2008; Minami et al. 2009c). Predation is expected to be an important mortality factor for ungulates (wapiti, Cervus elaphus canadensis: Schlegel 1976, mule deer, Odocoileus hemionus: Unsworth et al. 1999, see also Linnel et al. 1995 for a review). Individuals that survive to the age of maturity under predation must be truly successful individuals (CluttonBrock et al. 1982a). Predation risk is also expected to vary greatly with the species of predator, individual (deer) age, and the situation of predation. Therefore, predation may confound attempts to determine how the abilities of an individual deer affect survival and reproductive success. In fact, mortality patterns will vary depending on whether predation occurs from wolves or ravens. Hence, examining mortality in the absence of predation allows a suitable analysis with fewer complicating variables. On Kinkazan Island, there are no predators of sika deer, with the exception of Jungle crows, Corvus macrorhynchos. Sport hunting is prohibited on the island for religious reasons. The island is therefore a suitable site to study mortality factors of sika deer in the absence of significant predation. Information obtained under such conditions could then be compared with mortality factors and patterns from populations experiencing predation. The objective of this research was to determine the mortality and factors related to the mortality of sika deer fawns living on an island that has no strong predation pressure.


This text highlights the aesthetic explorations of Bulgarian cinematographers from the 1980s, specifically those aimed at people of art. The article offers, first, a brief overview of films that examine the symbolic potential of the artist, which defines the consideration of an established and meaningful tendency in the development of Bulgarian cinema. The article focuses then on the live-action film Illusion (1980, directed by Lyudmil Staykov and written by Konstantin Pavlov) and examines the figure of the artist in the piece. The presented interpretation supports the view of the film as a morally valuable expression of modern art.


In an isolate of tobacco mosaic virus, TMV U1, a small subpopulation of virus that invokes the hypersensitive reaction on Nicotiana sylvestris Spegaz. & Comes exists and is strongly selected for during replication in plants that are undergoing development of shoot axes during bolting. Virus of this phenotype (NL) can infect and move systemically in rapidly developing parts of N. sylvestris plants and is strongly selected for in upper tissues of the plants only during the development of the shoot axis. This selection results in a dramatic change in the genetic composition of the virus population in the upper part of the plant. No accumulation of NL-type virus occurred when N. sylvestris plants were inoculated with TMV204, a clonal population derived from RNA transcripts of a plasmid carrying a cDNA copy of the TMV genome.


The purpose of this investigation was to determine which illumination wavelength produces the largest differences between the fluorescence emission spectra of normal and atheromatous vascular tissue. The fluorescence spectra for 12 excitation wavelengths ranging between 270 nm and 470 nm were examined and compared. The Hotelling trace, a figure of merit describing class separability, was used to compare the excitation wavelengths. Preliminary results indicate that illumination in the range from 314 nm to 334 nm consistently performed well. Wavelengths in the 364 nm to 436 nm range also showed promising performance for a limited data set. These results were found to be relatively independent of the catheter angel and distance to the tissue.


The relations of twelve-tone rows are of theoretical, analytical, and compositional interest. While relations based on the properties and transformations of rows have been widely studied, less attention has been paid to relations based on similarity. Formal similarity measures can be used to explicate ways of being similar. This study presents an analysis and categorization of 17 similarity measures for twelve-tone rows. Nine of them are new. The categorization of the similarity measures suggests the notion of different conceptions of twelve-tone rows. Five such conceptions are identified and explicated: vector, ordered pairs, subsegments, subsets, and interval contents. Similarity measures could thus be grouped into families based on the conception that they suggest. The similarity of twelve-tone rows allows two interpretations: comparison of the properties of the rows and the measurement of their transformational relations. The latter could be conveniently formalized using David Lewin's Generalized Interval Systems as the framework. This allows the linking of the discussion on permutations in mathematics and computer science because the measurement of the complexity of a transformation coincides with the notion of presortedness of permutations. The study is in three parts. The first part gives an overview of the types of relations between twelve-tone rows, and presents a formalization of twelve-tone rows and row operations in terms of group theory. The second part focuses on the properties of similarity. By way of background a review and criticism of the literature on similarity in music theory is presented. The transformational approach and the metric are promoted. It is shown that transformational similarity measures create perfectly symmetrical spaces since every row is related to the other rows by precisely the same set of transformations. Since most of the similarity measures discussed in this study are dissimilarity measures of the distance between rows, the mathematical concept of the metric is applicable; many similarity measures define a metric. One of the main findings is that any metric for twelve-tone rows that is transformationally coherent under the operations generating row classes also defines a metric for those row classes. The third part discusses the similarity measures and the respective conceptions in detail. While the study focuses on the similarity of twelve-tone rows, the possibilities of extending the measures to the examination of other ordered pitch-class sets are also discussed. The work concludes with some examples of their analytical application.


The manuscript (ms) entitled "Zooplankton diel vertical migration and downward C into the Oxygen Minimum Zone in the highly productive upwelling region off Northern Chile" by Tutasi and Escribano showed the results of day and night zooplankton vertical distribution at two oceanographic stations at 20oS and another at 29oS, in an area influenced by the coastal upwelling off Chile and the presence of a sharp oxygen minimum zone (OMZ). This is a quite interesting and valuable data set about the vertical distribution of the different groups and species of zooplankton in relation to the OMZ. They also showed the diel movements of the different zooplankton groups and species and their


We show that a disordered ensemble of dielectric particles near the Mie resonances has anomalous depolarizing properties. Under the first Kerker condition the depolarization length of circularly polarized light reaches its peak value, and can be ten times greater than the transport mean free path. The second Kerker condition is shown to be satisfied as the refractive index of particles increases. In this case, the depolarization length is minimum and almost coincides with the mean free path.


Objective To investigate the clinical curative effect on the lower extremity deep venous thrombosis by using artery catheterization thrombolysis. Methods With Seldinger′s technique, catheter was placed into popliteal artery through the contralateral healthy side femoral artery and then the thrombolytic and anticoagulant agents were dripped into the thrombotic popliteal artery. Results In the treatment group, symptoms improved in all patients(100%), disappeared in 25 patients(83.3%). In the control group, symptoms improved in 15 patients(75%), disappeared in 7 patients(35%). The differences were significant (P 0.01). The comparison of limb parameters pre and post treatment was obviously excelled to the control group(P 0.05). The treatment was not only suitable in early stage but also as well for the serious ones in advanced stage. In the treatment group, the time for the swell of the low extremity to subside was≤7 days, the difference was significant compared to the control group. Conclusions Arterial catheterization thombolysis is an effective method in treating deep venous thrombosis of the lower extremity, anticoagulant agents is important in treating deep venous thrombosis of the lower extremity .


In 2018 nearly 10% of Indonesians lived in poverty and a significantly larger number were at risk of falling into poverty.  Health promotion efforts which target this population ideally need to be holistic and multilevel so as to address the inequities they experience in health, nutrition, living conditions, education, and employment.  This paper explores the potential of traditional Indonesian stories as a health promotion tool and seeks to open discussion into how they can be used in the future.  Narratives have the potential to influence people's beliefs, knowledge, attitudes, values and behaviours.  They are increasingly used in health communication due to their ability to overcome resistance in the listener, culturally ground messages and reach less educated audiences.  While the use of traditional Indonesian stories in early childhood education is well documented, their potential to address multiple social determinants of disease in a public health context has not been explored.  Indonesian stories are a rich source of local wisdom containing important messages about environmental preservation, food wastage and social values such as honesty, justice and peace.  They can also be adapted to focus on hygiene, nutrition and encourage preventative health actions. Stories which build resilience and courage might be helpful for the poor, while stories that highlight injustice and discrimination could promote equity in the mindset of the powers that oppress them. There are several limitations however, so an indiscriminate use of traditional stories would be inadvisable.  In conclusion it appears that traditional storytelling is currently an underutilised health promotion tool in Indonesia and its potential as a low cost, culturally appropriate and enjoyable way to address determinants of health at multiple levels could be further explored.


A series of macrocyclic bis(carbene) ligands were synthesized by linking 2,2″-bis(imidazole)terphenyl with a methylene, ethylene, propylene, or borate unit. Coordination complexes of iron were synt...


A number of cases of sinusoidal hematolymphoid malignancy ("malignant histiocytosis") in which early lymph node biopsies have not allowed clear separation from benign histiocytic disorders have been observed. Nine such cases in which only a follow‐up lymph node biopsy documented their malignant nature are reported. Seven of the nine patients were under 21 years of age; there was an even sex distribution. All had localized or generalized lymphadenopathy and three had hepatosplenomegaly at initial presentation. Histologically, the initial lymph node biopsy specimens showed an atypical sinusoidal proliferation, often with hemophagocytosis, but without sufficient atypia to allow a diagnosis of malignancy. The analysis of the follow‐up biopsies, performed from 6 weeks to 5 years after the initial biopsy, showed a progression in histology with an increase in atypia, a greater tendency to efface lymph node architecture, and a decrease in hemophagocytosis. All patients were treated with chemotherapy. Six patients ultimately died; at autopsy, these patients showed a pattern of organ involvement typical of what has been described for malignant histiocytosis.


Let $\mu$ be a Borel probability measure associated with an iterated function system consisting of a countably infinite number of contracting similarities and an infinite probability vector. In this paper, we study the quantization dimension of the measure $\mu$ with respect to the geometric mean error. The quantization for infinite systems is different from the well-known finite case investigated by Graf and Luschgy. That is, many tools which are used in the finite setting, for example, existence of finite maximal antichains, fail in the infinite case. We prove that the quantization dimension of the measure $\mu$ is equal to its Hausdorff dimension which extends a well-known result of Graf and Luschgy for the finite case to an infinite setting. In the last section, we discuss the stability of quantization dimension for infinite systems.


A 6–18 GHz wideband cavity‐backed log‐periodic‐slot end‐fire antenna with vertical polarization for conformal application is presented. The log‐periodic folded slots and parasitic slots with 10 slot elements are applied to cover 6–18 GHz frequency band and the log‐periodic metallic cavity is placed under each slot element to keep wideband performance and prevent the effects of large metallic carrier on radiation patterns. The ground plane etched with log‐periodic slots is reversed and touched directly to the backed cavity and a dielectric cover is added to the antenna, to further improve the antenna performance. Meanwhile, a broadband microstrip‐coplanar waveguide transition is inserted in the antenna for measurements. With these designs, the proposed antenna shows good impedance matching (|S11|<27 dB) and end‐fire gain (>4 dBi) performances in 6–18 GHz. The proposed antenna also keeps low‐profile and easy flush‐mounted characteristic which is suitable for conformal applications of high speed moving carriers.


In view of the unreasonableness that the value of parameter α is set artificially in the current statistical model,a nonlinear current statistical model and CS-UKF algorithm to estimate the state and α adaptively are proposed.The simulation result shows that the CS-UKF algorithm converges more quickly and the estimation result is more accurate.


This paper evaluates, as proposed by Laxton and N'Diaye (2002), if the consideration of a measure of monetary policy credibility in the forecast of the Brazilian Phillips Curve, after the introduction of inflation targeting, implies an improvement. The findings denote that the use of a measure of monetary policy credibility for the Brazilian economy can provide a statistical model with a forecast quality for unemployment-inflation trade-off better than models of inflation that consider a stable relation between inflation expectations and inflation.


On the basis of the actual conditions of the design theory and manufacture technology of mechanical springs, the defects existing in the traditional inspection test and the calculation methods on the coil springs for passenger cars are analyzed, the inspection test and the calculation methods of the automatic inspection and repair assembly line for the coil springs for passenger cars are described, and the technical advantages of the methods are explained.


The paper reviewed the progress of study on secondary wall formation in plants, including the main experimental systems, methods, technologies used in the studies, and molecular architecture of secondary wall, the role of cytoskeleton, phytohormone, Ca 2+ and calmodulin in the secondary wall formation. Furthermore, the relationship between the secondary wall formation and programmed cell death (PCD) was discussed.


In this paper we will display a new method for measuring the temperature of a LED backlight display. Generally the LED junction temperature (Tj) is the key factor for lifetime estimation and it can be measured by the forward voltage variation when the LED is turned on under small driving current. Unfortunately the forward voltage measurement is a destructive and non‐direct method for the display and we can get only a few LED information. We found that by recording the Wp (peak wavelength) of the display spectrum, a non‐destructive LED backlight display lifetime evaluation method can be developed. By also, the lifetime of the display can be calculated simply.


Insertion sequences (ISs) and other transposable elements are associated with the mobilization of antibiotic resistance determinants and the modulation of pathogenic characteristics. In this work, we aimed to investigate the association between ISs and antibiotic resistance genes, and their role in dissemination and modification of antibiotic resistance phenotype. To that end, we leveraged fully resolved Enterococcus faecium and Enterococcus faecalis genomes of isolates collected over four days from an inpatient with prolonged bacteremia. Isolates from both species harbored similar IS family content but showed significant species-dependent differences in copy number and arrangements of ISs throughout their replicons. Here, we describe two inter-specific IS-mediated recombination events, and IS-medicated excision events in plasmids of E. faecium isolates. We also characterize a novel arrangement of the IS in a Tn1546-like transposon in E. faecalis isolates likely implicated in a vancomycin genotype-phenotype discrepancy. Furthermore, an extended analysis revealed a novel association between daptomycin resistance mutations in liaSR genes and a putative composite transposon in E. faecium offering a new paradigm for the study of daptomycin-resistance and novel insights into the route of daptomycin resistance dissemination. In conclusion, our study highlights the role ISs and other transposable elements play in rapid adaptation and response to clinically relevant stresses such as aggressive antibiotic treatment in enterococci.


This paper introduces a new type of flexural pivot, which is a substitute for cross-stripe flexural pivot in the servo- reflector in ICF Laser Driver in China for higher stability and resolution. This paper presents force analysis model of the new flexural pivot. On the basis of force analysis, the torsional stiffness and rotational center drifting are calculated theoretically. In the meantime, FEM and a prototype test were carried out to verify the theoretical result. The integrated test shows that the new flexure pivot can provide sensitively adjusting with low center drifting. The resolution of the stepper-reflector system reaches 2 (mu) rad. And the repeatability of the reflectors with this new type flexural pivot is no more than 0.1 (mu) rad.


A new existence theorem for maximal elements is established in noncompact L-convex spaces.As application,a minimax inequality and a saddle point theorem in noncompact L-convex spaces are obtained.


ABSTRACT Over a number of years, universities have needed to become more adept at managing change as internal and external factors affect their longer term financial sustainability. That sustainability is, for many institutions, closely linked to how straightforward (or otherwise) it is to recruit student numbers of the right quality from often diverse markets. However, the scale of a university's financial challenge isn't always enough on its own to dictate how bravely an institution drives its change agenda, nor the nature and pace of change.


INTRODUCTION
We report on a 22-year-old male patient who presented with an intrapelvic tumor.

CASE REPORT
CT and MRI showed a left pelvic abscess, which was drained. After regression of the abscess, we removed the causative tubular structure surgically, revealing a rudimentary genital structure with parts of the Mullerian and Wolffian ducts.

CONCLUSIONS
This case report demonstrates an abscess formation as complication of a previously asymptomatic rudimentary genital structure, which was associated with further abnormalities, such as left testicular agenesia, perineoscrotal hypospadias and transverse testicular ectopia.