Under the social environment of market economy, it is better to have persons of all-around quality rather than just having qualified technical skills. The vocational and technical colleges shoulder the responsibility of cultivating people of this sort. In order to combine English teaching with quality education and enhance the cross-cultural communicative competence and innovative spirit of the students, exlporing a humanistic model of English teaching is very important and necessary.


Land in Australia is more abundant than in almost any other country in the world and urban land, like rural land and mineral wealth, ought to be a component of the nation's comparative advantage. Urban land use, however, is subject to strict State or Territory Government regulation on the supply of land for housing. This increases land prices and housing costs. Restraint of land supply also has a significant impact on commercial activities like shopping centres. Regulatory limitations on the availability of land for shopping centres dampen competitive pressures and bring about higher retail prices. Land costs are incorporated in most commercial activities. Hence, beyond the direct effects on housing and commercial property, measures that raise the price of land have a pervasive effect in raising costs throughout the economy. An important by-product of regulatory-inflated land and housing prices is the consequential soaking up of savings that might otherwise be allocated to productive investment. A wind back of restrictions on land availability for home building and other urban uses would reduce housing prices and costs for land intensive urban activities as well as releasing savings for beneficial uses. This paper examines the impact of urban development regulations on land and housing prices and explores the consequences for national savings and investment.


This paper summarizes observations about net carbon erosion and re-deposition in the limiter tokamak TEXTOR, and the divertor tokamaks ASDEX Upgrade and JET. The major carbon source in TEXTOR is the toroidal graphite belt limiter. Eroded carbon is mainly re-deposited on net deposition dominated areas of that limiter, and on areas perpendicular to the magnetic field in the scrape-off layer. In ASDEX Upgrade and JET the major carbon sources are located in the main chamber. Eroded carbon is re-deposited on the divertor tiles in the inner and to a lesser extent outer divertors. Carbon migration to remote areas without direct plasma contact like the JET louvres, or the area below the divertors II and IIb of ASDEX Upgrade, is observed. Soft, hydrogen rich hydrocarbon layers with a deuterium to carbon ratio of 0.7–1.4 are formed in these areas. Precursor for this layer formation is sticking of hydrocarbon radicals like CD3 or C2Dx (x = 1, 3, 5) created by re-erosion of deposited hydrocarbon layers on the divertor tiles.


AMONGST the most frequently employed of all medicines are the so-called anti-pyretics; yet their use is at present entirely empirical, since we have no scientific knowledge concerning their influence upon the thermic functions of the animal organism. This is not because no attempt has been made at investigation, but because these attempts have been misdirected. The bodily temperatare is the result of the play between two antagonistic functions-heat production and heat dissipation (see Dr. H. C. W o o d's Memoir on Fever). Until we know whether a given drug which lowers bodily temperature doesso by diminishing the production of caloric,, or by increasing the dissipation of the animal heat, we have not the fundamental facts of the case, and any deductions are no better than speculations. The only calorimetrical studies hitherto performed upon any drug are those of Dr. B evan L e wi s, which we shall again refer to. The method employed in the present investigation is that used by Dr. H. C. Wood in his research upon fever, so that no further explanatioll is needed. Unfortunately Dr. R1eichert was forced by circumstances to leave Philadelphia before the completion of the plan which had been laid out for work. The present memoir is therefore incomplete, but is published because the labour involved in this kind of investigation is so great that few are willing to undergo it, and any solid work is of corresponding value. Without further preamble we present in tabular form the experimental results we have obtained'


The National Clinical Programme for Older Persons outlines that each hospital should have a dedicated Specialist Geriatric Ward (SGW) with appropriate staffing and access to Health and Social Care Professionals. As part of a quality improvement initiative to drive the development of a new SGW, we examined what proportion of older medical admissions had care needs that would be best served in a Specialist Geriatric Ward.

 We completed a retrospective cohort study of unselected medical admissions over a two week period in a level four hospital. We established criteria that would deem a patient suitable for admission to a specialist geriatric ward and examined the journey of patients who were or were not admitted under the care of Geriatric Medicine.

 In total over the two week period there were 307 admissions, with 144 over the age of 75 years (47%). Over half of patients had more than one bed moves during their inpatient stay. 78% were frail. 109 (75%) of patients would have been eligible for care on a specialist geriatric ward. 20% of the over 75 year olds were admitted under the care of Geriatrics. 72% of the remaining patients admitted under general medical teams would have met the criteria for care on a specialist geriatric ward. 20% of this cohort had a review by the frailty at the front door team with 23% having an inpatient geriatric medicine consult.

 A significant proportion of older adults being admitted have care needs that would benefit from coordinated care on a specialist geriatric ward. Patients receive input from geriatric medicine through a variety of avenues but there is a need for increased access to specialist geriatric inpatient wards. This would improve patient access to the Right Care, in the Right Place at the Right Time.


Red cabbage (Brassica oleracea var. capitata f. rubra) is also known as purple cabbage or red kraut. It is an important fancy and highly nutritive exotic vegetable. It belongs to the family brassicaceae and comes under the subgroup rubra of cabbage (Brassica oleracea var. capitata L.). It is having chromosome number 2n=2X=18. Red cabbage is a native crop in the Mediterranean region of Europe and now grows all over the world as a fresh market vegetable. Red cabbage synthesized and accumulated anthocyanin at all the developmental stages of vegetative growth (Yuan, 2009).It is a cool season crop and widely grown in temperate and subtropical region of India. The transition from vegetative to reproductive growth is triggered by temperature. The optimum temperature for International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 9 Number 1 (2020) Journal homepage: http://www.ijcmas.com


Nutrient intake by grazing animals depends on the amount of dry matter consumed and its chemical composition. Forage grasses produce assimilates during the day via photosynthesis to sustain live tissues, plant growth and organic reserves (Taiz and Zeiger 2013). In that context, herbage chemical composition may vary according to variations in the photosynthesis-respiration balance throughout the day. From dawn to dusk photosynthesis predominates and herbage dry matter content and concentration of soluble carbohydrates increase; the reverse happens from dusk to dawn. That could influence nutritive value and nutrient intake of grazing animals (Delagarde et al. 2000), since for a given bite volume the amount of herbage and its composition could vary depending on the time of the day. This phenomenon could have implications for rotationally managed pastures, with time of changing animals from one paddock to the other assuming greater importance. Against that background, the objective of this experiment was to evaluate dry matter (DM) content and the concentrations of soluble carbohydrates (SC), crude protein (CP), neutral (NDF) and acid (ADF) detergent fiber in herbage samples harvested during the morning and afternoon periods from rotationally stocked elephant grass (Pennisetum purpureum) cv. Napier.


The reaction of graft copolymerization of xylan with 4-coumaric acid by laccase-catalyzed oxidation,in a way to improve quality of filming of xylan. It was analyzed by infrared FT-IR analysis,13 C NMR analysis,Py-GC / MS analysis techniques for determining the reaction between xylan and 4-coumaric acid which were chemically connected,and occurred copolymer. By testing the degree of polymerization,results showed that the degree of polymerization of the xylan improved 17. 78%; and the films showed a significant increase in Young 's modulus by 25. 29%,tensile strength increased from 0. 601 to 0. 753 MPa and 1. 020 to 1. 218 MPa,respectively. The grafting between xylan and laccase-catalyzed oxidation of 4-coumaric acid played an important role in reinforcing the films. The superior properties of the new films could have great potential applications.


Objective:To investigate the effect of proanthocyanidin-fixed decellularized valved bovine jugular vein conduit(BJVC),and to establish the experimental foundation for the further application it in cardiovascular surgery and tissue engineering. Methods:Twenty-four BJVCs,randomly divided into 3 groups and fixed with proanthocyanidins(decellularized BJVCs fixed with 0.5% proanthocyanidin),glutaraldehyde(decellularized BJVCs fixed with 0.625% glutaraldehyde) and the control group(fresh BJVCs), respectively.The morphologic and mechanical properties of BJVCs in the 3 groups,including thickness,diameter,moisture content, denaturation temperature,tensile strength,elongation at break,fixed index and the in vitro enzymatic degradation resistance,were detected.And the vitro cytotoxicity test and hemolysis tests were applied in the biological evaluation of the fixed BJVCs.Results:1.The cells compounds removed thoroughly,fiber stents to maintain complete;2 There were no significant differences in its effect of these two crosslinking agents,though the crosslinking speed of proanthocyanidin was slower than glutaraldehyde;3 There were no difference in wall thickness,diameter between proanthocyanidin group and fresh group.Though the tissue water content of proanthocyanidin fixed tissue was inferior to fresh tissue,it was still higher than glutaraldehyde fixed tissue.For fixation of biological tissue with glutaraldehyde or proanthocyanidin,denaturation temperature, tensile strength and elongation increase at break as well as in vitro enzymatic degradation resistance.There were no significant differences in denaturation temperature and the in vitro enzymatic degradation between glutaraldehyde and proanthocyanidin fixed tissues.However,the tensile strength and elongation at break of the proanthocyanidin fixed tissueswere significantly superior to that of the glutaraldehyde fixed tissues.4 The hemolysis tests showed that hemolysis rate of fixed tissues which fixed with glutaraldehyde or proanthocyanidin,respectively,5%,in line with the national biological materials hemolysis test standards,but the group of fixed with proanthocyanidin was significantly lower than that of glutaraldehyde.And the vitro cytotoxicity test showed that cytotoxicity of the proanthocyanidin fixed tissues was lower than that of the glutaraldehyde fixed tissues.Conclusions:Proanthocyanidin is an effective and suitable approach for crosslink BJVC without toxicity compared with glutaraldehyde,and it has a good research and application prospect in improving the physicochemical properties of BJVC.


Building on a group-level perspective on helping, we investigated the processes that lead domestic students to support international students in the context of voluntary peer-pairing programs. Results from a laboratory and a field study (total N = 198) confirmed that when international students came from culturally similar countries, empathy was a motivator of domestic students' helping intentions and behavior. Among culturally dissimilar dyads, however, helping was more contingent on the evaluation of international students' individual attributes. As moderated mediation analyses suggest, this effect was due to an increase in perceived relationship satisfaction, but, as expected, only among culturally dissimilar dyads.


Contents Contributors iii Introduction Markus Dirk Dubber & Mariana Valverde, Perspectives on the Power and Science of Police 1 Chapter 1 Mark Neocleous, Theoretical Foundations of the "New Police Science" 000 Chapter 2 Pasquale Pasquino, Spiritual Police and Earthly Police: Theories of the State in Early Modern Europe 000 Chapter 3 Mariana Valverde, "Peace, Order, and Good Government": Police-Like Powers in Postcolonial Perspective 000 Chapter 4 Markus Dirk Dubber, The New Police Science and the Police Power Model of the Criminal Process 000 Chapter 5 Lindsay Farmer, The Jurisprudence of Security: The Police Power and the Criminal Law 000 Chapter 6 Alan Hunt, Police and the Regulation of Traffic: Policing as Civilizing Process 000 Chapter 7 Mitchell Dean, Military Intervention as "Police" Action? 000 Chapter 8 Ron Levi & John Hagan, International Police 000 Conclusion Christopher Tomlins, Framing the Fragments. Police: Genealogies, Discourses, Locales, Principles 000 Index 000


Disclosure of criminal evidence is an important regulation in criminal procedural system. The essay is based on the analysis of nowadays situation of disclosing of criminal evidence, and it expounds practical significance of establishing disclosure of criminal evidence. Meanwhile, it puts forward the conception of establishing disclosure of criminal evidence.


This research is, first of all, a theoretical study concerning 'conflict.' Only then, we could obtain ways in which we manage and resolve...


This paper discusses the four modes of the made-up world of Beijing poem fictions-producing "virtual image" with artistic conception,changing the memory to make them like poems,using dreams and valuable childlike heart to make up a world.


It is well known that the large majority (more than 90%) of IP traffic on the Internet is today carried by TCP connections. Moreover, it is quite realistic to suppose that the largest part of best effort traffic will use TCP also in the future. So, this protocol is and will be a fundamental element for the evaluation and forecast of IP network performance. TCP has been studied for many years, and a lot of models have been proposed for it that can be found in the scientific literature. However, most of them are related to a single connection behavior. In this respect, the aim of this work is to propose a model for aggregate TCP flows that could give a good representation of TCP performance in a network with an acceptable level of precision but also of complexity. Our model can be consider a "fast" simulation model, i.e. it is based on a sort of simulation (event generations and performance measures), which, however, is very fast, because it operates at aggregate level by using a fluid approximation, so that the computational time it requires is comparable to that required by a relative by complex analytical model. The paper reports several tests and comparisons with NS2 simulations, which show the quite good precision of the proposed TCP model. Keywords—TCP connections modeling, Networks modeling, TCP performance evaluation.


Rhodium(III) can be exchanged between the layers of α-zirconium phosphate by employing the pre-swelled diethanol intercalate, α-Zr(HPO4)2(ethanol)2. During the Rh3+/H+ exchange, four rhodium-containing phases are formed with different interlayer distances. However, only the fully Rh-exchanged compound, α-ZrRh0.66(PO4)2.4H2O, is obtained as a pure phase. Rhodium(III) can also be exchanged into the layered intercalation compounds α-Zr(HPO4)2(bipy)0.251.5H2O (bipy = 2,2′-bipyridyl), α-Zr(HPO4)2(phen)0.52H2O (phen = 1,10-phenanthroline) and aZr(HPO4)2(dmp)0.5·2.5H2O (dmp = 2,9-α-dimethyl-1,10-phenanthroline). Exchange is accompanied by a partial elution of the diamine for the phen and dmp derivatives. Various materials are obtained and their thermal properties discussed. X-Ray photoelectron spectroscopy (XPS) gives evidence that RhIII-diamine complex species mixed N- and O-coordinated RhIII are formed in the interlayer region of the three intercalation compounds.


E-mail: firstname.lastname@example.com Background: Electrical stimulation of the lateral rectus muscles (LRMs) is a physiotherapeutic technique used in the treatment of comitant esotropia. Posttreatment changes in the neuromuscular system of the eye have been not estimated previously due to the lack of an appropriate method for investigating the electrical activity of the extraocular muscles (superficial electromyography (sEMG) technique). Purpose: To employ the recently developed ocular sEMG technique in order to assess changes in the neuromuscular system of the eye in comitant esotropia before and after electrical stimulation of the LRMs. Materials and Methods: Twelve children (24 eyes) with comitant esotropia underwent electrical stimulation of the LRMs using the Amplipuls-5 apparatus. In addition, an electromyography recorder (M-TEST-2) was used to assess the function of the muscles in accordance with our sEMG methodology before and after treatment. Results: After treatment, the amplitude of the sEMG signal from the LRM insignificantly decreased from 11.55 ±2.3 to 10.64 ± 0.7 mV (p > 0.05), whereas the frequency significantly increased from 49.7 ± 3.6 to 63.18 ± 8.2 Hz (p < 0.05). In addition, the amplitude and frequency of the sEMG signal from the medial rectus muscle insignificantly (p > 0.05) decreased, from 11.48 ± 0.5 mV to 10.2 ± 0.9 mV and from 101.96 ± 5.6 Hz to 94.7 ± 19.5 Hz, respectively. Conclusion: The sEMG technique allows for estimating changes in frequency and amplitude of the response of the LRMs before and after electrical stimulation. In children with comitant esotropia, an improvement in the imbalance between the activity indices of lateral and medial rectus muscles was observed after electrical stimulation of the extraocular muscles.


SIGNIFICANCE
A mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow--hypoxic vasodilation--occur in an attempt to restore oxygen supply. Nitric oxide (NO) is a major signaling and effector molecule mediating the body's response to hypoxia, given its unique characteristics of vasodilation (improving blood flow and oxygen supply) and modulation of energetic metabolism (reducing oxygen consumption and promoting utilization of alternative pathways).

RECENT ADVANCES
This review covers the role of oxygen in metabolism and responses to hypoxia, the hemodynamic and metabolic effects of NO, and mechanisms underlying the involvement of NO in hypoxic vasodilation. Recent insights into NO metabolism will be discussed, including the role for dietary intake of nitrate, endogenous nitrite (NO₂⁻) reductases, and release of NO from storage pools. The processes through which NO levels are elevated during hypoxia are presented, namely, (i) increased synthesis from NO synthases, increased reduction of NO₂⁻ to NO by heme- or pterin-based enzymes and increased release from NO stores, and (ii) reduced deactivation by mitochondrial cytochrome c oxidase.

CRITICAL ISSUES
Several reviews covered modulation of energetic metabolism by NO, while here we highlight the crucial role NO plays in achieving cardiocirculatory homeostasis during acute hypoxia through both vasodilation and metabolic suppression.

FUTURE DIRECTIONS
We identify a key position for NO in the body's adaptation to an acute energy supply-demand mismatch.


The non-premixed Oxy-CH₄ flame characteristics were studied in a lab-scale slot burner for industrial furnace design. To estimate the flame stabilization, flow velocity was varied upto u F =50 ㎧ for methane gas and u Ox = 100 ㎧ for oxygen gas. The flame stabilization curve showed that lifted flame region became broaden with oxygen inlet temperature (T Ox ) increase and slot separation width decrease. In addition, the carbon-dioxide (CO₂) dilution to oxidant debilitated the flame stabilization due to reduced oxidant concentration and chemical reaction.


When worms process 1 ton of organic waste in terms of dry matter, 600 kg of biohumus is obtained, and the remaining 400 kg are transformed into 100 kg of complete protein in the form of worm biomass. Raw materials for biohumus in California worms, in addition to livestock and crop waste, can be fallen leaves, household organic waste and other organic and biological waste. The study and widespread use of the products of the California red worm is an extremely important task in the cultivation of biologically high-quality agricultural products, as it is possible to obtain high yields of environmentally friendly products without excessive use of synthetic fertilizers. The largest number of vermiculture of the California worm was found in the heated room - 348 individuals, while in the non-heated room they were 12.9% less - 303 individuals per box. The increase in the number of vermiculture of the California worm in the heated room was 42.5%, and in the unheated room - 34.0%. The weight of biohumus produced by California worms after 180 days of development in the heated room was 1647 g per container, which was 35.8% more than in the version of the development of worms in the unheated room. The use of compost in the cultivation of cabbage helped to increase its yield by 33.9%, and cucumbers - by 26.9%. The use of organic waste as a raw material for biohumus is a promising area for the development of organic farming. Breeding of red California worms of the genus Eisenia for processing organic waste should be carried out at a temperature of 23-25 ° C and use the products of their activity - compost for fertilizing vegetable crops, which provides a yield increase of 26.9-33.9%. The use of vermiculture products in organic farming is a powerful factor in improving the ecological state of the environment, as well as a necessary condition for the sustainable functioning of agroecosystems.


The Constitution of Human Rights in Brazil was conceived in the fight against the dictatorial system that existed in Brazil for 21 years (1964-1985), having as protagonists in the denunciation of tyrannies, the Christian Churches, especially the Roman Catholic Church. And many of the social agents who had fought for its establishment had in Liberation Theology (TL) a fundamental theoretical tool. Since then Human Rights have been discussed and transformed into legal institutes or have even been created in the perception of a great part of the population as something that leads to the formation of the citizen person. The proposed work aims to conduct an analytical study on the ecumenical basis found in much of the conceptual principles of Liberation Theology and its consequent reflexes in the country's political discussions related to national programs of Human Rights.


Acute myeloid leukemia (AML) is one of the most common hematologic malignancies derived from a small number of self-renewing leukemic stem cells (LSCs). AML has various genetic abnormalities such as chromosomal aberration, single nucleotide variant and insertion/deletion. In particular, internal tandem duplication of FMS-like tyrosine kinase 3 (FLT3-ITD) is the most frequently found in ~ 25 % of AML cases, moreover, AML with FLT3-ITD is classified in unfavorable. FLT3 is fundamentally essential for survival of hematopoietic stem cells (HSCs) as well as LSCs, but once ITD is acquired, FLT3-ITD promotes the proliferation of AML by activating downstream enzymes. Various FLT3 inhibitors are now available as effective and promising drugs. On the other hand, the resistance against those inhibitors has been regarded as an emerging problem in clinics.
 To clarify the molecular machineries how AML cells acquire the resistance against FLT3 inhibitors, we compared the mutation status of paired AML samples consisted of diagnostic and relapsed samples. LSCs, which are quiescent and highly resistant against conventional chemotherapies, are considered to play a central role in recurrence. Since we and other group previously reported that TIM-3 clearly discriminates LSCs from residual normal HSCs, we purified and evaluated the mutations of CD34+CD38-TIM-3+ LSCs or CD34+ immature AML cells. The paired diagnostic and relapsed samples obtained from the identical 5 AML patient treated with Gilteritinib were subjected to whole exome sequencing (WES) analysis. CD3+ T cells were also purified from the diagnostic samples and used as a germ line control to detect somatic mutations acquired in AML cells. Libraries for WES were prepared using Sure Select XT HS and Human All Exon V6 Capture Kit in accordance with manufacturer's instructions. Then we performed WES using NextSeq 500 with 150bp pair-end read.
 Surprisingly, in all 5 cases examined, AML clones lost FLT3-ITD, whereas clones harboring mutations potentiating RAS-MAPK signaling became dominant at relapse: one case acquired the activated KRAS (Q61H) mutation and the remaining four cases newly acquired the previously-unidentified mutations in RAS-MAPK inhibitory genes. Such mutations in RAS-MAPK-inhibitory genes include DIRAS3 (W173X), RASA1 (E70G), RAP1GAP2 (K18X), RIN2 (S355fs), RASA4 (C655R), RASA4B (E141G), MAP2K7 (T66P) and PTPN7 (T14M). Of note, these genes belong to RAS-MAPK-inhibitory pathways and the encoded proteins are reported to suppress the activity of RAS-MAPK pathways. These RAS-MAPK-inhibitory mutations were exclusively detected in the relapsed AML clones, and contained stop-gain and frameshift mutations. We, therefore, hypothesized that RAS/MAPK activation driven by somatic mutations contributes to the acquisition of resistance against FLT3 inhibitors in LSCs.
 Consistent with such hypothesis, phosflow analysis revealed that basal ERK phosphorylation was retained or rather increased in the relapse CD34+ AML cells lacking FLT3-ITD, indicating that RAS-MAPK activation was maintained independent of FLT3-ITD. Furthermore, ASP2215 and AC220 inhibited ERK phosphorylation in the diagnostic CD34+ AML cells, whereas both inhibitors failed in the inhibition of ERK activation in the relapsed AML clones in all 3 cases analyzed. Gilteritinib also failed in inhibiting ERK in other relapsed AML cases, however, the combination of ASP2215 and MEK inhibitor efficiently suppressed ERK phosphorylation.
 All of relapse AML cases exhibited the emergence of AML clones harboring mutations associated with RAS-MAPK pathway genes, and therefore, the clinical sequence for detecting such mutations might be useful to assess the risk of FLT3-inhibitor treatment failure in clinics. Furthermore, our study showed the efficacy of MEK inhibitors to inhibit RAS-MAPK signaling activity even in the relapsed AML cells. Thus, the combination therapy consisted of FLT3-inhibitors and MEK inhibitors might be one of the promising therapeutic strategies to overcome FLT3-inhibitor resistance in AML. In summary, our study revealed that mutations potentiating RAS-MAPK pathway should play a central role in conferring the resistance against FLT3-inhibitors to AML.

 Akashi: Sumitomo Dainippon, Kyowa Kirin: Consultancy; Celgene, Kyowa Kirin, Astellas, Shionogi, Asahi Kasei, Chugai, Bristol-Myers Squibb: Research Funding.


We present a random fuzzy tactical planning model for the production and distribution of agricultural products because of the uncertainties encountered in the whole process. In the proposed model, the crops' yields are uncertain and assumed to be characterized by random fuzzy variables with known probability and possibility distributions. The model approach selected is a two-stage hybrid uncertain programming in which the decisions in a first stage are designed to meet the uncertain outcomes in a second stage. Since it is always difficult to handle with the random fuzzy model directly, we apply an approximation approach (AA) to evaluate the value of the objective function and discuss the convergence the AA. Considering that the approximating model is neither linear nor convex, it cann't be solved via the conventional optimization algorithm. Therefore, an approximate-based hybrid particle swarm optimization (PSO) algorithm is designed to solve the proposed model. Finally, an application example is presented to highlight the significance of the random fuzzy production and distribution model as well as the effectiveness of the solution method.


Natural convection laminar flow from an isothermal sphere immersed in a viscous incompressible optically dense fluid in the presence of radiation effects has been investigated. The governing boundary layer equations are transformed into a non dimensional form and the resulting nonlinear systems of partial differential equations are reduced to local non-similarity boundary layer equations, which are solved numerically by two distinct, efficient methods, namely, (i) implicit finite difference method together with the Keller box scheme and (ii) local non-similarity method. Numerical results of the velocity and temperature profiles of the fluid are presented. The results of the shearing stress and the heat transfer rate in terms of skin-friction coefficient and Nusselt number respectively are also presented for a wide range of the radiation-conduction parameter or Planck number R d (=0.0, 1.0, 2.0, 3.0), the surface heating parameter θ w (=1.1, 1.2, 1.4), and Prandtl number Pr (=7.0, 10.0, 15.0, 20.0).


Purpose
In spite of being a significant public health concern, quality of life (QoL) amongst elderly in nursing home (NH) settings is rarely analyzed. The purpose of this paper is to examine the level of QoL and factors influencing QoL amongst elderly NH residents in Indonesia.

Design/methodology/approach
A survey was conducted amongst 181 elderly at three NHs in three districts in Yogyakarta province, Indonesia. Purposive sampling was used for the study site and sample collection. Face-to-face interviews were performed using the WHO Quality of Life BREF Indonesian version questionnaire to assess elderly QoL. Multivariate linear regression was performed to determine the factors influencing the QoL amongst elderly NH residents.

Findings
The response rate was 66.3 percent. A total of 64.1 percent of elderly had a fair level of QoL, whereas 16.6 percent still had a poor level of QoL. A total of 86.7 percent of elderly lived in an NH due to compulsion, and more than half (53.6 percent) perceived inadequacy of care. The QoL was significantly low amongst those who live in NHs due to compulsion, no social support resources, not receiving any kind of support, having three chronic diseases and perceived inadequacy of care (p<0.05). Multivariate analysis revealed that perceived adequacy of care reasons for living in NH was associated with QoL (p<0.001).

Originality/value
Perceived adequacy of care and reason for living in an NH were highlighted as predictors of QoL amongst elderly NH residents. Improving adequate healthcare services and developing treatment strategies to enforce the adaptation process is required in order to maintain the QoL in elderly NH residents.


A kind of for determining that direction of visual lines or sight line (include direction of visual lines vector sum position vector in the 3 d space, such as, position vector instruction pupil midpoint and the place that starts of direction of visual lines vector) 3D rendering analyzer be configured to receive first group of view data and another group image information, wherein, first image comprises from the first visual angle, three dimensional object is shown to the pattern first plane of delineation, and wherein, another group described comprises with hypograph, this image includes from another visual angle, same three dimensional object is shown to the pattern another plane of delineation, or wherein, another group described includes the relation between at least two point in the first image and/or image information and/or at least positional information.Image information is determined based on the first image or other images one or more.Positional information describes the relation between at least one point and first plane of delineation of three dimensional object.Described 3D rendering analyzer includes position calculator and alignment computer, and calculates the direction of visual lines in 3d space.


Introduction Cladribine tablets (Mavenclad®) are licensed for treating people with relapsing multiple sclerosis (pwRMS). We treated people with relapsing (pwRMS) and progressive MS (pwPMS) using sub- cutaneously administered cladribine (SCAC) since 2014. Here, we present up to five year follow-up on safety and efficacy. Methods SCAC 10mg was given on 3–4 days during week 1. 0–3 doses were administered at week 5, according to week 4 lymphocyte count. A second cycle of SCAC was administered 11 months later. Follow-up included clinical outcome evaluation and pharmacovigilance. The proportion of pwMS with no evidence of (i) disease activity (NEDA) and (ii) progression or active disease (NEPAD) was calculated. Results 211 pwMS received SCAC. 154/211 completed two treatment cycles. At baseline age was 44 (17–72) years, EDSS 1–8.5. Tolerability was good. One myocardial infarction and one breast cancer occurred. Two severely disabled pwMS died (one of influenza, one of encephalitis). Lymphopenia grade 3 was detected in <3%. At 2 years, 71% (CI 54%, 85%) of pwRMS had NEDA; 38% (CI 23%, 54%) of pwPMS had NEPAD. Conclusions SCAC was well tolerated. Frequency of significant lymphopenia was low. Efficacy in pwRMS corresponds with trial data. NEPAD rates in pwPMS were similar to licensed DMT. firstname.lastname@example.com


The study of"the nature of mind"is a core issue in the neo-Confucian philosophic thought.Xu Fuguan connected culture of mind with art of mind with his unique creative mind.He elaborated the origin of literary value and the important fundament of artistic creation,and further gave an humanistic explanation of the essence of art from the view of artistic creative subject.This thought has two features:The personality of the artist is determinative in his artistic creation so ihe premise of an artist's artistic individuality is his correctitude of disposition rather than the truthfulness of disposition.Furthermore,argument between Confucianism and Daoism in literary area is a resourceful topic while the"dictatorship"is the biggest barrier of literary development.


The invention belongs to the engineering measurement technology and specifically discloses an array mechanism of a laser spot projector with an adjustable light spot density. The array mechanism comprises a cylindrical base, a rear end cover, a front end cover, a force applying rod and an auxiliary supporting ring. Circular-ring array blocks which are arranged into circles around the center of the rear end cover are arranged on the outer end surface of the rear end cover; a ring-shaped slot is formed between adjacent circular rings; a laser device fixing hole is formed in the center of the circular-ring array blocks. The circular-ring array blocks which are arranged into circles are designed on the rear end cover made of an elastic material, and the ring-shaped slots are formed among the circles, so that elastic deformation formed by the ring-shaped slots is generated between the circular-ring arrays when the force applying rod drives the rear end cover to move, and a normal of each circular hole generates deflection for a certain angle, thereby generating or converging or diverging a laser spot matrix on the target to generate a laser spot array adaptive to a target dimension size, and solving a problem that characteristic spots cannot be extracted under a high-brightness background.


We establish $L^p-L^q$ estimates for averaging operators associated to mixed homogeneous polynomial hypersurfaces in $\mathbb{R}^3$. These are described in terms of the mixed homogeneity and the order of vanishing of the polynomial hypersurface and its Gaussian curvature transversally to their zero sets.


This study examines the effect of job design on job satisfaction among Doctors and Nurses in selected hospitals. Data were collected from a sample size of 400 medical personnel (Nurses and Doctors) employed in four major medical centers in Lagos, Nigeria. Results from Pearson product moment correlation revealed that job design is associated with all dimensions of job satisfaction. In addition, the findings also revealed group differences among Doctors and Nurses on measures of job satisfaction. Finally, the study shows that job design alone may not explain all the variations in job satisfaction. This implies that other factors may contribute to employee job satisfaction. Research and managerial implications of these findings are discussed.

 Key words: Job design, job satisfaction.


Abstract Neutral red and Bismarck brown Y were tested as immersion stains for sockeye salmon fry. Although initial mortalities were low in experiments using Neutral red, all fry regardless of concentration or immersion time were dead on the 4th day. Controls survived well. Three experimental groups of fry stained in Bismarck brown Y solutions were conspicuously stained after a week, and total mortalities were low during 7- and 13-day holding periods.


Stearoyl-CoA desaturase (SCD) is a central enzyme responsible for the synthesis of monounsaturated fatty acids - mainly oleate. Recent studies have shown that SCD1 plays also a significant role in the regulation of lipid metabolism. SCD1-deficient mice have increased energy expenditure, reduced body adiposity, increased insulin sensitivity and are resistant to diet-induced obesity and liver steatosis. SCD 1 was found to be specifically repressed during leptin-mediated weight loss, and leptin-deficient ob/ob mice lacking SCD1 showed markedly reduced adiposity. In addition, SCD1 deficiency completely corrects the hypometabolic phenotype and hepatic steatosis of ob/ob mice and attenuates fasting-induced liver steatosis in PPARα-deficient mice. Lack of SCD1 expression also improves insulin action in skeletal muscles and prevents diet-induced hepatic insulin resistance in mice. Much evidence indicates that the direct anti-steatotic and anti-diabetic effects of SCD1 deficiency stem from the decreased tissue lipid content caused by enhanced fatty acid oxidation and reduced lipid synthesis. In this review, we discuss our current understanding of the role of SCD1 in insulin resistance and regulation of hepatic lipid partitioning, and test the hypothesis that pharmacological manipulation of SCD might be of benefit in the treatment of non-alcoholic fatty liver disease and in the prevention of diabetes.


Abstract The results of an experimental investigation of the mechanical properties of boron carbide (B4C) and molybdenum disulphide (MoS2) reinforced aluminium alloy (AA2024) hybrid composite samples, processed by stir casting process are reported in this paper. Based on the previous studies, it was concluded that for 4% of weight of the B4C powders reinforced in AA2024 metal matrix have better mechanical properties like tensile strength and hardness than the base alloy. Also the 4% of MoS2 reinforced in AA2024 metal matrix exhibited good mechanical properties than the matrix metal. Hence an attempt has been made to further improve the properties of the composite using both B4C and MoS2 as reinforcement particles in the AA2024 matrix. in the present study hybrid composite specimen were developed varying the weight% of B4C and MoS2, viz., 1%+3%, 2%+2%, 3%+1% B4C and MoS2 respectively in the AA2024 matrix. The prepared samples were subjected to a series of mechanical tests like tensile and hardness tests. Further, SEM & XRD analyses were performed on the prepared samples to study the microstructure and to ensure the proper dispersion of the reinforced particles in the metal matrix.


Recently, there has been renewed interest in the importance of the small airways (internal perimeter <6 mm) in asthma 1. This was initiated largely by the observation that the use of the inhaled corticosteroid beclomethasone as a small-particle formulation, with greater penetration to the peripheral lung, results in similar improvements in symptoms and lung function at half the delivered dose of standard formulations of beclomethasone 2. The structure of the small airways is altered in asthma, even in mild cases 3, and structural changes in the small airways will theoretically lead to greater alterations in airway mechanics than similar changes in the central airways 4. Therefore, it seems desirable to find a way to safely assess the pathology of small airways in asthma. Transbronchial biopsy (TBB) is not the way to do it, at least not yet.

In this issue of the Journal, Balzar et al. 5 have shown that small airways are present in 45% of TBB specimens from patients with severe asthma. In the same cases, the density (cells·mm−2) of inflammatory cells in the small airways (membranous bronchioles and smaller) seen in TBB was greater than the density in endoscopic bronchoscopic biopsies (EBB) from medium and large airways (cartilaginous bronchi) of patients with severe asthma. The authors conclude that TBB may be used to assess pathological changes in small airways in asthma. They have shown considerable endeavour in highlighting the potential of these tissue specimens for study. However, TBB should not yet be regarded as a useful tool for assessing asthma, for two reasons: 1) the significance of greater numbers of inflammatory cells·mm−2 in the distal airway compared with central airways as a marker of a pathological process needs to be validated; and 2) the usefulness of the results does not outweigh the …


Radioactive calcium uptake, radioactive calcium outflow and total tissue calcium concentration were studied in isolated left rabbit atria under varying conditions of stimulation and varying external calcium, sodium and potassium concentrations. Three different tissue-calcium compartments were demonstrated in both resting and stimulated atria: 1) an unexchangeable tissue-calcium compartment. 2) a rapidly exchangeable tissue-calcium compartment. Its rate of exchange was increased by stimulation of the atrium at various rates. The effects of rate of stimulation on calcium exchange were seen after 1-min but not after 5-min exposure to radioactive calcium. The rate constant for the outflow from the second compartment was not altered by stimulation. The half-times of calcium movements into and out of this compartment are sufficiently rapid to account for the speed with which changes in the external calcium concentration alter contractility. It was proposed that the concentration of calcium in this compartment is a determining factor of contractile force. 3) a tissue compartment into which uptake was increased and outflow was decreased by stimulation, resulting in a net gain of tissue calcium. This calcium compartment is probably not directly related to changes in contractile force since its rate constant is too slow to account for the rapid changes in contractility produced by the addition or removal of calcium in the external medium.


Medical science has made great contributions to the health care of human beings.However,humanistic spirit in medical science is gradually weakened.Issues concerning life,humanity,and spirit that deserve attention are actually ignored.This paper elaborates the humanistic factors of medical science with the supporting evidence of the purpose and humanistic dimensions of medical science,the humanistic spirit of medical science,and the relationship between medical development and humanistic education.It proposes that strengthening humanistic education is not only an important approach to the reconstruction of humanity in medical science,but also an intrinsic requirement of medical development.


The utility model provides a hybrid-power motor-train-unit traction converter suitable for multiple power-supply modes, and the traction converter comprises a traction transformer interface, a power pack interface, a first pre-charge device, a second pre-charge device, a rectifier, a direct-current link, and a traction invertor. The traction transformer interface is connected with the input end of the rectifier, and the power pack interface is connected with the input end of the rectifier. The direct-current link is in parallel connection to the direct-current bus of the output end of the rectifier. The output end of the rectifier is connected with the output end of the traction invertor. The output end of the traction invertor is used for connecting with a traction motor of a motor train unit. The first pre-charge device is disposed on a circuit between the secondary side of a traction transformer and the rectifier. The second pre-charge device is disposed on a circuit between the power pack interface and the rectifier. The traction converter provided by the utility model can operate on an electrification circuit and a non-electrification circuit at the same time, and can achieve self-rescue through the power pack and an energy storage device.


Identification of the role of specialized school psychologists in addressing cross-cutting issues across multiple systems (i.e., school reintegration, adherence to treatment programs, pharmacological management) is necessary. The interdisciplinary training process covers a three year span. See Table 2 for a description of the training elements and the following pie charts for time allocated to didactic instruction, field-based instruction, supervision, and research during each year of training.


This paper describes a microprocessor-based (Zilog Z80) position control system for an X-Y table which is a precision specimen stage in an electron-beam lithographic machine used to define patterns on semiconductor wafers. The controller receives commands which specify the coordinates, on a user specified Cartesian grid, to which the workpiece is to be moved. After checking that the requested position is within the table's movement range the microprocessor rotates and translates these user coordinates into the representation used by the position sensor, a two-axis laser interferometer. This interferometer measures the positions of mirrors, which are mounted on the specimen table, to an accuracy of 79 nm. Coarse positioning of the table is achieved by means of stepper motors which drive a pair of crossed lead screws whilst fine adjustment of the specimen's effective position is provided by applying a small offset to the electron-beam deflection drivers via digital-to-analogue converters. Thus although the table is only near to the required position, the specimen is nevertheless effectively aligned with the working point of the electron-beam. When the table has been placed in the desired position and come to rest, a signal is given to indicate that processing may resume. An operator panel provides for push-button manual control of the drive motors and a liquid crystal display shows the table's position.


ARIETIS-NS is a Rad-Tolerant, space qualified 3-axis gyro, whose main applications are Telecom (15+ years GEO), Earth Observation as well as Science and Exploration missions. It mostly uses commercial EEE components that are upscreened by means of radiationtesting. ARIETIS-NS is in the process of being qualified to ESA ECSS standards, meeting the most stringent space quality requirements. ARIETIS-NS, as his Hi-Rel equivalent ARIETIS gyro, is based on Innalabs proprietary Coriolis Vibratory Gyroscope (CVG) technology which is currently used in commercial products for land, marine, and aerospace applications. Innalabs CVG gyros, as presented previously at this conference, have already accumulated more than 2,500,000 hours in space on board a Low Earth Orbit constellation with no failures and no deviation from the specified performance, confirming the suitability of the technology to space environment. ARIETIS-NS has already been selected for a variety of space applications and environments such as LEO, GEO, and heliocentric orbits. Thanks to the support of the European Space Agency, the development of ARIETIS-NS is now complete and qualification testing is ongoing with target completion date in Q4 2022, ahead of delivery of the first flight models. ARIETIS-NS is able to provide high performance (ARW <0.005 deg/$\sqrt{\text{hr}}$) and high reliability (~1000 FITs) in a very compact design (~1.2 kg for LEO application) and very low power consumption (<7W). To achieve this, several targeted enhancements and optimisations to InnaLabs gyroscope's design have been introduced, mainly in the component selection, the control loops, the compensation algorithms, and a smaller Sensing Element design. After a brief description of the InnaLabs CVG basic principles and an overview of the CVG technical strengths in comparison to competing technologies, this paper describes the specification, key design features, and budgets of ARIETIS-NS. The paper will present the flexibility embedded in the design and the different configuration of the unit. These include different box thickness for LEO vs GEO applications, different data buses supported, the possibility of changing gyro bandwidth depending on customer needs. Testing and verification approach is then introduced. A number of Engineering Models (EM) as well as Engineering Qualification Models (EQM, practically identical to Flight Models) have been built as part of the verification campaign. Test results obtained with both models are presented to validate ARIETIS-NS specification. These include performance tests (bias stability, scale factor stability, noise, and misalignment), mechanical tests (vibration and shocks) as well as thermal vacuum tests. Test results show that ARIETIS-NS meets and exceeds its specification.


Mobile Adhoc Network (MANET) is a selfconfiguring infrastructureless network of mobile hosts connected by wireless links. The wireless links in the network are highly error prone and can go down frequently due to mobility of nodes. Therefore, energy efficient routing over MANET is still a critical task due to highly dynamic environment. In this paper, a link cost model is derived to accurately track the energy consumption on different factors. Then the route discovery and route maintenance is found with the minimum energy routing protocol and the PEER protocol. IEEE 802.11 DCF uses exponential backoff algorithm. In this, average backoff value is increased after every collision due the large size of contention window. So, considerable proportion of bandwidth is lost due to collision. Due to that the energy consumption is increased. we propose a Modified Progressive Energy Efficient Routing Protocol (MPEER) protocol using FIB with a quick and low overhead path discovery scheme and an efficient path maintenance scheme for reducing energy consumption especially in mobile environment. "Fibonacci Increment Back off (FIB)" mechanism is used to improve the performance of the bandwidth for energy efficient routing in ad hoc networks. The experimental analysis of proposed protocol has been carried out using network simulator NS-2.


Enzymatic treatment of fruit juices to reduce the bitterness has got advantages such as the higher quality of juice due to the lower haze and non-deterioration of juice quality. The pomegranate has recently been acclaimed for its health benefits, in particular, for its disease-fighting antioxidant potential. Presence of high tannin content in the pomegranate is responsible for haze and sediment formation as well as for colour, bitterness and astringency of the juice upon storage. Due to the inability of conventional fruit juice debittering processes for removing the bitterness effectively, enzymatic debittering should be preferred. This present work is aimed at the debittering of pomegranate juice using tannase, which has potential applications in the degradation of tannins. The juice was treated with tannase (10% v/v) of 35.6 U/mL at 37oC for two h and then the enzyme was inactivated at 50°C for 30 min. Tannase treatment resulted in 25% degradation of tannin while a combination of tannase and gelatin (1:1) resulted in 49% of tannin degradation. Ascorbic acid content, pH, total sugar, protein, and viscosity of both the treated and non-treated fruit juices were studied.


Scenario-based approach is applied to evaluate alternatives. Using the ideas of Dempster-Schaeffer a capacity distribution is defined over scenarios. This allows describing possible future developments in terms of individual and integrated expert judgments and transforming expert judgments into scenario assessments. To get a final numerical estimate of alternatives, we use integration over non-additive measures applying the Choquet integral.


Objective To describe and analyze the 4 years economical compensation situation for urban community health service in a certain provincially administered municipality,and find existent major problems.Methods The data of urban community health service in this provincially administered municipality was collected and analyzed so as to fine the existent major problems.Results The compensation situation for urban community health service in the municipality was not good,the major problems were an inadequate government investment,undertaking numerous free service、nonstandard item charge,and supplementing medical service through drugs.Conclusion The compensation mechanism of urban community health service in a certain provincially administered municipality is unreasonable.It needs an urgent regulation and improvement,and the corresponding strategy should be actively taken aiming at the problem.


The knitting of information and modern electronic technology with agricultural production system to determine, analyze and manage the critical temporal and spatial factors of farm for maximizing profitability, sustainability and environmental protection is need of hour. In this context, robot (Arial, Ground and Under-water) can play an important role. Aerial Robot is also commonly known as Unmanned Aerial Vehicle (UAV) or Drone. It may be boon for management of agricultural production as it can focus on small crop fields at lower flight altitudes than other regular aerial vehicle to perform site-specific farm management operation with higher precision. It can also address adverse crop and land prerequisites, where use of conventional machines is challenging, e.g. spraying under wet paddy field, tall crop sugarcane, pigeonpea etc. Embedding the available technologies and methods for meeting functional, operational and structural requisite, specifically for the crop and land environment with Arial Robot is of utmost importance. On the basis of system range, accuracy, resolution, and precision, sensitivity, linearity, offset, hysteresis and response time of different sensing and control technologies, e.g. optical, near infrared, thermal multi-spectral, hyper-spectral, Light Detection and Ranging, radio frequency and sonar .This paper presents an overview of research involving the development of UAV technology for agricultural production management. Technologies, systems and methods are analyzed for in situ integration under Indian farm conditions. The limitations of current Arial Robot for agricultural production management are deliberated, moreover forthcoming needs and suggestions for development and application of the technology in agricultural production management are projected.


This is a magnificent volume. Volume it has, all 170 cubic inches of it, and weight; at ca. 5 lbs it is surely not suited to bed-time reading. But it is certainly a wonderful deskside companion that offers a treasury of classic papers from Buffon to the epic biogeographical decade of the 1970s and a little beyond. Published in association with the International Biogeographical Society and the U.S. National Center for Ecological Analysis and Synthesis, this work continues the successful Foundations series, Foundations of Ecology (1991) and Foundations of Animal Behavior (1996) from the University of Chicago Press. Seventy-two key works are presented in eight sections that cover Early Classics (Buffon, Linnaeus, Forster, de Candolle, Humboldt, Darwin et al.), through Earth History; Vicariance and Dispersal; Species ranges; Revolutions in Historical Biogeography; Diversification; The Importance of Islands; Assembly Rules and Gradients in Diversity. Each section is introduced with a Commentary, each of which is a perceptive critique of the papers to follow. All 72 papers are too many to note separately, but all are well chosen and great reading. Your reviewer is not a biogeographer by profession and it may have been presumptuous of me to review this book, but my rationale is that the contents transcend Biogeography sensu stricto. They present major facets of the history of ideas in Biology and they document the interwoven approaches to understanding the evolution and distribution of organisms: life in time and space. It will be an essential book for seminars and advanced courses in Biogeography. More than that, it would be a salutary exercise for students of cell and molecular biology to read selected chapters, if only to sense that there is more to the study of Life, that rigorous thinking can be applied to global issues and that great science was done more than a century ago. Every reader will find treasures here—papers often quoted but seldom read—and translations of classics from German and French. My own favorites include Linnaeus on the creation of all species on a high mountain in Paradise and their subsequent differential increase on the habitable Earth. Alexander van Humboldt, arguably the founder of modern Biogeography, is represented by his famous essay on the distribution of plants, and Wegener by his theory of the origin of continents and oceans. Por, whose work was not previously known to me, discusses the Suez Canal as a biogeographical experiment. Brundin, who is among the few with multiple entries and a pioneer on transantarctic relationships, defends his differences with Darlington. All the usual suspects are there from more recent decades: Simpson, Hulten, Elton, Croizat, Mayr, Wilson, MacArthur, Brown, Diamond and Whittaker to mention only a sample of the many greats. In sum this is an essential volume for all Biology libraries, both institutional and private, and a bargain at the price.


The simplest neutrino mass models based on $A_4$ symmetry predict $\theta_{13} = 0$ at tree level, a value that contradicts recent data. We study models that arise from the spontaneous breaking of an $SO(3)$ symmetry to its $A_4$ subgroup, and find that such models can naturally accommodate a nonzero $\theta_{13}$ at tree level. Standard Model charged leptons mix with additional heavy ones to generate a $\theta_{13}$ that scales with the ratio of the $A_4$-breaking to $SO(3)$-breaking scales. A suitable choice of energy scales hence allows one to reproduce the correct lepton mixing angles. We also consider an alternative approach where we modify the alignment of flavons associated with the charged lepton masses, and find that the effects on $\theta_{13}$ are enhanced by a factor that scales as $m_\tau/m_\mu$.


After retroperspektive analysis, we found that the problem of quality audit service is current direction of research both in Ukraine and in the world. The key information users to trust management companies and auditors problem is the quality of financial reporting and its verification. Investors must be confident that the financial information on which decisions are taken on economic capital allocation, is accurate and reliable. Proposals to develop common standards caused sharp criticism of some experts, who claim that intracompany audit standards should be individual and tailored to suit a particular firm. Development of samples will significantly speed up the implementation of standards for small audit firms by working out common standards taking into account of own of features. Using a proprietary internal standards in the auditing firm enhances audit quality and audit services.


Liver cancer is the sixth most common cancer worldwide in terms of the number of cases (626,000 or 5.7% of new cancer cases) but due to the very poor prognosis, the number of deaths is nearly similar (598,000). The survival rate is 3% to 5% in cancer registries for the United States and developing countries. The modality of treatment in hepatocellular carcinoma (HCC) patients depends on the stage of the disease. The Barcelona Clinic Liver Cancer Classification (BCLC) is the favorite staging system. There are many patients who initially present with the intermediate-stage disease, and in this setting transarterial chemoembolization (TACE) is the treatment of choice.
The purpose of this article is to highlight and discuss the role of chemoembolization in the treatment of hepatocellular carcinoma, including the results of recent large studies, and the concept of combined therapies, illustrating our case.
The differences in individual factors that are not captured by the BCLC framework, such as the tumor growth pattern, degree of hypervascularity, and vascular supply, complicate the further evaluation of these patients. Because of these differences, not all patients benefit equally from TACE. Several tools have been devised to aid the decision-making process which have shown promising initial results but have failed external evaluation and have not been translated to the clinical aspects. Criteria for treatment decisions in daily clinical practice are needed in all stages of the disease.
Conclusion: TACE is a safe method for prolonging patients' survival with unresectable HCC. The correct treatment of HCC is concentrated in cancer centers, and cooperation between multiple specialists is necessary.


As the rapid development of renewable energy and electrification of transport, the stability and efficiency of power system will encounter inevitable challenges. A decentralized Vehicle-to-Grid (V2G) framework for fast charging infrastructures joining in the primacy frequency regulation is proposed in this paper to cope the fluctuation of renewable energies. Two interaction modes are transferred according to the state of charge (SOC) of PEVs (Plug-in electric vehicles) in order to meet the fast-charging demand of drivers primarily. Based on the engineering system of vehicle battery pack, we fabricate detailed interaction logics among fast charger, V2G controller, battery pack and battery management system (BMS). The effective V2G control strategies need to consider the power limitations and charging effects. As a consequence, an equivalent circuit battery model (ECM) with high accuracy for dynamic and fluctuation working conditions is employed to obtain power limitations of lithium-ion batteries (LIBs). Furthermore, fast-charging-oriented droop control strategies are designed to participate regulation of power grid with negligible impact on fast charging. An alternative current (AC) power system with high penetration of renewable resources is constructed to verify the effects. The results of case study reveal that the proposed method with bidirectional chargers can reduce the fluctuation from renewables, loads and PEVs by 21.22%, accompanied by PEVs' SOC changes lower than 0.5%. Interestingly, a high renewable penetration system can eliminate frequency derivation by adding PEVs with proposed regulation.


This ultrastructural study of phenytoin-induced gingival overgrowth in rats demonstrates a statistically significant increase in myofibroblasts (18.5 cells/1×104μm2 area; control, 5.7;p<0.01, Wilcoxon test). The increased presence of these cells may be interpreted by either of two mechanisms: 1) phenytoin, along with the promotional influence of inflammation, elicits excessive repair (overgrowth) similar to that of wounds where myofibroblasts play an important role, or 2) this lesion reacts like tumor or other active proliferative conditions where myofibrolasts represent one form of host-tissue response.


Some free logicians regard all such simple statements as asserting of the objects to which the constituent singular terms purport to refer that they are things which . (Here and elsewhere the blanks are to be filled in by appropriate verbs or verb phrases.) So, for instance, (1) and (2) respectively assert of Vulcan that it is a thing which rotates around its axis and, among other possibilities, that it is a thing which is the same as Vulcan. This kind of linguistic intuition underlies the conviction of many free logicians that all simple statements of the fragment of colloquial discourse in question imply the existence of the purported referents of their constituent singular terms, and hence that if the purported referents fail to exist, the host statement is false. Free logics of this sort are called negative free logics. Other free logicians regard simple statements of the fragment of colloquial discourse in question merely as asserting that the objects to which the constituent singular terms purport to refer So, for instance, the sentences (1) and (2) respectively assert that Vulcan rotates around its axis and, among other possibilities, is the same as Vulcan. Accordingly, even if all the singular terms are irreferential — as in (2) —the truth-value of the host statement need not be false, and, indeed, is true in the case of (2). (1) is either true or truth-valueless. This kind of linguistic intuition underlies the conviction of many free logi-


After sanctions in the 2000s were imposed, the cooperation with China that helped Zimbabwe to cope with the crisis at home and on the international arena. The object of research in this paper is the Sino-Zimbabwean relations. The subject of the study is the interaction and cooperation between China and Zimbabwe in politics and economics in the period 2000-2019. The purpose of the study is to assess the main areas of Chinese–Zimbabwean cooperation in 2000-2019. The author examines the evolution of interaction in the political and economic sphere between China and Zimbabwe, identifies the factors that influenced cooperation in these areas. The novelty of this study lies in a comprehensive assessment of the development trend of Chinese-Zimbabwean cooperation in the field of politics and economics in the period 2000-2019. The systematic method allowed us to consider the trend of cooperation in the field of politics and economics between the PRC and the Republic of Zimbabwe on the basis of extensive use of sources. The author concludes that cooperation between China and Zimbabwe is important in the context of the foreign policy of both countries. This multifaceted alliance in the political and economic spheres contributes to the development and strengthening of diplomatic ties, which have an impact on the common prosperity of both countries.


Ensuring the effectiveness of physical education of students with chronic health conditions is possible only if proper test control system is available. Taking into account the importance of the conclusions that are made in accordance with its results, the questions of objective assessment and correct interpretation of monitoring results acquire a special urgency. Purpose. Theoretical modeling of the monitoring and evaluation component of test control in physical education of students with chronic health conditions. To achieve the goal such methods are used: analysis and synthesis, systematization and generalization of research results of ascertaining and forming stages of the experiment, the theoretical modeling. Results. The principal provisions of the developed model of monitoring and evaluation component of the test of students with chronic health conditions are presented. The practical implementation of the proposed assessment technology provides personal approach in assessing and objectivity of information processing. Novelty and innovation of represented monitoring and evaluation component are based on the integral assessment. At the same time, it provides maximum weighty and detailed information about the individual dynamics of parameters of students' psychophysical condition under the influence of physical education.


The paper focuses on the basic constitutional basis of market regulation as a prerequisite for the institutional framework of such regulation. It focuses in more detail on the issue of the independence of market regulators, including competition authorities and the surveillance authorities for public procurement from the perspective of European Union law. Based on the individual and partial rules and those stemming from the case law of the Court of Justice of the European Union, it is gradually creating a mosaic of independence rules which should apply equally to all market regulators, including the public procurement authority.


For footwear insoles, high rebound performance is required in some instances such as for running, while softness for comfort is of higher importance during normal walking and standing to minimize high stress. Hence, materials with rebound performance in some scenarios and softness for other scenarios are desired. In this paper, we investigate rebound performance and hardness of composites made of a shear-thickening material and elastic foam. First, a hydrogel type of shear-thickening material (Slime) is characterized to investigate the influence of water content. After that, two particular shear-thickening hydrogels with better rebound performance (but not outstanding in the shear-thickening effect) are selected and integrated into the elastic foam to produce a composite insole. It is found that, as compared with the commercial elastic insole and commercial shear-thickening insole, softer and superior rebound performance can be achieved simultaneously only if the right shear-thickening material is used in the composite.


Nanometer technologies are exposed to several sources of variability, among these, Power Supply Noise (PSN) has become a mayor challenge. This paper provides a broad perspective of the causes and effects of PSN along with the evolution of techniques that have been proposed to deal with it, which heavily rely on the information that can be gathered from in situ monitoring circuits. A detailed taxonomy of power supply sensors is also presented, paying attention to important parameters for the PSN problem, such as duration of the minimum detected pulse, range of detection, latency or range of temperatures covered.


Contemporary school is a subject of the process of structural and program changes. These changes imply searching for ways to build its culture. One of the elements of the school's culture is community. Building a school as a community of life, work and service for another human being, smaller and larger communities and the Homeland becomes an important task. The basic condition for the implementation of this task is axiological education and upbringing towards values. The presented material will show the axiological determinants of building a school as a community. Particular attention will be paid to axiological education and upbringing towards values in the field of human qualities as a factor determining the building a school in the community dimension.


In the last 50 years, interest in the phenomenon of colonization of new habitats by immigrating organisms has increased considerably. Advances in transportation, construction and industrial technologies have enabled the transfer of plants and animals to areas not occupied previously. Despite eVorts by ecologists and geneticists, no universal criteria for predicting successful potential colonizers have been formulated (Ehrlich, 1986). Moreover, factors that determine colonization success appear to be so diverse that the formulation of universal criteria is impossible (Safriel & Ritte, 1980; Golani, 1993). A unique opportunity for the study of colonization events was the involuntary introduction of Fundulus heteroclitus L. in southern Spain. The history of F. heteroclitus introduction in Spain is diYcult to retrace. Its introduction might be fairly ancient. Machado-Nunez as early as 1857finds a Mediterranean coast speciesValencia hispanicain the south of the Iberian Peninsula. Later, Buen (1930, 1935) renames it Fundulus hispanicus. More recently, possibly the same species from southern Spain was described as a new species, Valencia lozanoi(Gomez-Caruanaet al., 1984). Valencia lozanoiwasfinally synonymized with F. heteroclitus (Fernandez-Delgado et al., 1986). Fernandez-Delgado (1989) proposes a later date of introduction, around 1970, probably when two other American species were voluntarily introduced in this region: the largemouth bass (Micropterus salmoides Lacepede) and the crayfish (Procambarus clarki). F. heteroclitus is a killifish that inhabits the estuary waters of the East Coast of the United States and Canada. Populations living from the cold waters of Nova Scotia, to the warmer waters of Florida have been shown to diVer at the behavioural, fitness, physiological, and DNA level (Powers et al., 1993). In this study we have tried to determine from which of the American populations the Spanish individuals are derived. Since the American populations were shown to be adaptationally diVerent, our longterm goal will be to investigate the fitness of the Spanish population relative to its new environment, and its eYciency to compete with a local killifish Aphanius iberus (Valenciennes). Cytochrome b (Cyt b) sequences for North American F. heteroclitus and for its close relative F. grandis Baird & Girard were taken from the literature (Bernardi et al., 1993; Bernardi & Powers, 1994). We will refer in this paper to northern population for


when addition and multiplication are defined in the obvious way, form a ring, the group-ring of G over K, which will be denoted by R (G, K). Henceforward, we suppose that K has the modulus 1, and we denote the identity in G by e0. Then R(G,K) has the modulus l.e0. Since no confusion can arise thereby, the element 1. e in R(G, K) will be written as e, and whenever it is convenient, the elements e0 in G and re0 in R(G, K) as 1 and r respectively. The symbol e, with or without subscripts, will always denote an element in G. If the elements Ex, E2 in R(G, K) satisfy JE1E2 = 1, Ex will be said to be a left unit, and E9 a right unit in R(G, K). If 77 is a left (or right) unit in K, then rje is a left (or right) unit in R(G, K). Such a unit will be described as trivial. The units in R(G, K) form a group if and only if every right unit is also a left unit. This is so, for instance, if both G and K are Abelian. It is also true if G is a finite group, and K is any ring of complex numbers, for then the regular representation| of G can be extended to give an isomorphism of R(G, K) in the ring of ordinary matrices. The first object of this paper is to study units in R(G,C), where C is the ring of rational integers. In § 2 we take G to be a finite Abelian group,


Complexity scalable algorithms are capable of trading resource usage for output quality in a near-optimal way. We present a complexity scalable motion estimation algorithm based on the 3-D recursive search block matcher. We introduce data prioritizing as a new approach to scalability. With this approach, we achieve a near-constant complexity and a continuous quality-resource distribution. While maintaining acceptable quality, it is possible to vary the resource usage from below 1 match-error calculation per block on the average to more than 5 match-error calculations per block on the average.


Food shelf-stable food or animal are disclosed. The food may or particulate component in the hollow, may be at least partially filled with a gaseous component, or two or more may core be coextruded component, at least partially surrounds one or more texture, to form a food having a flavor and color, has a substantially serial-based shell. .BACKGROUND


Based on optimal control theory with linear quadratic object function,a sequential optimal control (SOC) algorithm was developed using functional variation.The control gain matrix of optimal normal pressure on the damper was obtained by solving the object function with SOC.A more accurate numerical solution of the normal pressure was derived in form of pressure coefficients.The normal pressure can be adjusted to counter for the saturation of friction force and the lockup of the damper.Numerical simulation showed that the proposed algorithm is effective to achieve good performance for energy dissipation in the friction damper,and the peak response of inter-story drift and relative velocity are reduced evidently than those without damper.


The translation of non-standard language has often been recognised as a particular problem, although the issue has rarely been given detailed consideration. Most studies treat it as an isolated phenomenon. The present discussion explores implications arising from the interlingual transfer of dialectal forms of language where these are the dominant mode of discourse rather than merely sporadic devices in texts. The novels of the Irish writer Roddy Doyle are used here as an illustration of the central aspects of the problem. German translators of Doyle employ a variety of techniques in an attempt to convey the demotic idiom of the original texts, although inconsistencies remain, especially with regard to the regional quality, idiomaticity, modernity and extremism of the discourse.


Many attempts have been made to photograph those difficult markings, the canals of Mars. Although interesting pictures have been obtained, no photograph has shown the fine details described by visual observers. With the increased optical power and improved photographic techniques now available it may seem strange that better photographs have not been made. The explanation that large apertures are not adaptable to the problem, because seeing conditions are almost never good enough, is commonly accepted. Whether the word in italics offers any hope of success is now to be considered. My experience in observing the canals at the favorable opposition of 1939 is described here, not in any attempt to add to the already extensive literature on Martian canals, but to lay a basis of procedure for photographing them. Largely as a matter of self-education, I began early in 1939 a series of drawings of the planet with a 6-inch Clark refractor in Pasadena to verify, if possible, the well-known seasonal changes. After examining the planet carefully at the oppositions of 1907 and 1909 and casually in 1924 and 1926, I had arrived at the conclusion that the canals, if not largely chimerical, could be seen only with an eye of special adaptation and that my eyes were of the great majority which could not see them. Certainly I had no thought of ever seeing them with a 6-inch refractor. By midsummer of 1939 a small collection of drawings had been obtained. If such sketches of the planet were in color, the polar caps and certain temporary spots would be white, the shaded areas green, and the remainder of the planetary disk a


We investigated the insulation properties of different CF3I-N2 and CF3I-CO2 mixtures for further analyzing the possibility of applying these mixtures as substitutes for SF6 in high voltage apparatuses.Firstly,we calculated the reduced ionization coefficient α/N,the reduced attachment coefficient η/N and the reduced effective ionization coefficient(α-η)/N of the mixtures,where α,η and N are ionization coefficient,attachment coefficient and particle number density respectively.The results were compared with experimental values from references,which verified the method and parameters adopted in the calculation.Then in the same way,we obtained the α/N,η/N and(α-η)/N of different CF3I-N2 and CF3I-CO2 mixtures.Finally,setting(α-η)/N=0,we calculated the reduced critical electric field intensity(E/N)cr of different the mixtures.The results indicate that the(E/N)cr of pure CF3I is 439×10-17 V · cm2,which is much higher than that of SF6,366×10-17 V · cm2;when CF3I-N2 mixture has x(CF3I),mole fraction of CF3I,higher than 65%,its(E/N)cr is higher than that of SF6-N2;similarly,CF3I-N2 mixture with x(CF3I) 70% and CF3I-CO2 mixture with x(CF3I) 40% have higher(E/N)cr than pure SF6 and SF6-CO2 mixture,respectively.


Throughout the development of species, some vital ways of protecting the organism against dangerous materials and impact from the surroundings have developed. The pain response is most predominant; if an animal comes into contact with noxious stimuli, the pain response will initiate an immediate withdrawal and subsequent learning of protective behavior for the future. Similarly, if the skin comes into contact with harmful agents, a rash may develop, and in case of contaminated food, a strong smell may sometimes act as an important warning sign. If we by accident or ignorance get dangerous items into the body, there are systems to help us, such as the strong coughing reflex when solids or fluids get into the airway system. If we eat or drink substances that may be poisonous, diarrhea may help to clean the gastrointestinal cavities from substances otherwise absorbed. Nausea and vomiting also fit into this context. If we eat something potentially toxic, the rapid, forceful expulsion of gastric and duodenal contents will remove the potential dangerous substance before it gets absorbed into the blood. For this reason, we need receptors, such as the serotonin 5-HT3 receptors, on the intraluminal surface on the gastric canal to register potentially toxic contents inside the gut. Further, it may be a help to have receptors in close contact with the systemic circulation if some toxic substance starts to be absorbed from the gut to the blood. In that case, vomiting may limit the amount of substance that presents for absorption and also stop the oral intake of a larger amount. Whereas vomiting is a somewhat automatic, forceful response not requiring intellectual or deliberate decision making, nausea is different. For obvious reasons, we do not know if animals have developed the feeling of being nauseated, but in humans, nausea may be a strong source for learning. The prolonged, unpleasant feeling of being nauseated will tell us about food and situations we should avoid in the future. The general feeling of nausea during hypoxia, hypotention, and many cases of systemic disease


Tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) are more effective than placebo for the treatment of depression in primary care settings.


'BUS IDENTIFICATION FOR BLIND' outlines implementation of RFID for a bus detection mechanism to help blind in travelling from one place to another. Several solutions have been proposed like walking stick or white cane, guide dogs and GPS guidelines to deal with this difficulty. This paper intends to fill that cavity. Most systems provide only one-way communication and require high-cost and complex equipment. Therefore, this paper aims to develop a bus detection prototype using Radio Frequency Identification (RFID) for blind. RFID has the potential to be useful aids with further standardization of RFID tags and improvement of current RFID readers. Visually impaired people have difficulty accessing information about public transportation systems. Many technologies have recently made noticeable changes in several domains. This paper will shed the light on the field of transportation to improve the life quality of visually impaired persons (VIPs) using Radio Frequency identification.


The shallow depth of field (DOF) of the microscope is the inherent problem due to its high numerical aperture (NA), the paper proposed a method to extend the DOF by using spherical phase coding, DOF can be extended 2 times


From 2002 to 2005,  the Bureau of Drug and Narcotic, Department of Medical Sciences has organized a proficiency testing (PT) of Narcotic Drug Testing Laboratory 2 rounds per year with 4 samples per round.  Each year members were 12,12,52 and 41 laboratories, respectively.The reports of 2 rounds for each testing were evaluated. For qualitative testing, the prominent improvements in performances were found among the 3 year up members. Thus,the members that reported 100% totally corrected results increased from 2 of 12 in 2002 to 10 of 12 in 2005.The corrected results from 4 of 10 for 2 year members of 2005 were 80.0-93.3%.The quantitative testing was started in 2004, and 2 samples of each round were determined.By mean of robust statistics, more than 80% of the quantitative results from each test report were evaluated as satisfactory (/Z/≤2), but no any member reported the amount of Codeine Phosphate in solution. To increase the power of the test, in 2005, an assigned value of each sample was established from the assay values determined by Bureau of Drug and Narcotic, and a target deviation was defined as≤3% of the assigned value.The results of 1 and 2 round for Methamphetamine Hydrochloride from 8 of 22 laboratories and 6 of 13 were evaluated as satisfactory (/Z/ ≤2).However, the results of Methylenedimethoxymethamphetamine (MDMA)Hydrochloride from 12 of 22,and Methylenedimethoxyamphetamine (MDA) Hydrochloride from 11 of 13 laboratories were evaluated as unsatisfactory (/Z/≤3).This study provided the useful information and can be a guidance to improve the quality and standard of Narcotic Testing Laboratories in the future. Key words : Proficiency Testing, Narcotic Testing Laboratory, ISO/IEC 17025


Objective To study the effect of penehyclidine hydrochloride combined with droperidol on the side effects of morphine postoperative epidural analgesia. Methods Ninety-six AA four groups with 24 cases each.Single bolus of morphine 2 mg in normal saline in group A,single bolus of morphine 2 mg and droperidol 2 mg in normal saline in group B,single bolus of morphine 2 mg and penehyclidine hydrochloride 1 mg in normal saline in group C and single bolus of morphine 2 mg and penehyclidine hydrochloride 1 mg and droperidol 2 mg in normal saline in group D were injected into epidural space within 5 min after operation.Analgesic efficacy and side effects were observed and recorded during postoperative analgesia.Results Analgesic efficacy in group D was significantly better than that in the other three groups(P0.01).Side effects such as postoperative nausea and omitting skin pruritus,urinary retention and so on were significantly less in group D than those in the other three groups(P0.05).Conclusions Penehyclidine hydrochloride combined with droperidol can significantly reduce the frequency of postoperative side effects during epidural analgesia with morphine.


This article provides a meta-level framework which radically critiques the routine terms of reference with which we operate in a TINA (there is no alternative) society. Refusing the terms of reference for both the articulation of the 'problems' of contemporary society, and their possible resolutions, this article challenges core ideas about the nature of history, the individual, progress and development itself. It posits a convivial life as a realistic lifeworld for fully autonomous people in a commons-based society.


Objective To establish of the animal model of cervical instability and study the pathogenesis of cervical vertigo.Methods 60 adult healthy Japanese white rabbits were randomly divided into the experimental group(n=30) and the control group(n=30).The experimental group were given transection of posterior muscles of neck and supraspinous and interspinous ligament at C4/5,and then were given destruction of anterior longitudinal ligament and intervertebral discs at C4/5 form anterior approach.The control group were given a shame operation.Cervical extension and flexion position X-ray was taken at 1,2,3 months after operation.Relative motion degree of C4 was measured.Results There was no signifcant difference in relative motion degree of C4 between two groups at 1,2 months after operation(P0.05).There was signifcant difference between two groups at 3 months after operation(P0.05).Conclusion Cervical instability was induced by transection of posterior muscles of neck and supraspinous and interspinous ligament and destruction of anterior longitudinal ligament and intervertebral discs which provide a easy,effective animal model simialr to clinic deseases.


Abstract The aim of this research is to find the correlation between chemical compositions of biomass, including cellulose, hemicelluloses and lignin, and kinetic rates of biomass combustion. The combustion behavior of biomass constituent was studied by thermogravimetric analyzer. The correlations were generated by means of using Response Surface Methodology based on Simplex-Lattice experimental design. The results obtained from statistical analysis can be used to generate mathematical models and also contour plots which exhibited the relationship between biomass composition and its combustion kinetic. From the observation, the models and contour plots indicated the complexity of combustion mechanism. The correlations proposed by this research were expected to be potentially used to predict combustion behavior in case of real biomass.


WCDMA,one of the 3G standards,is commercially operated in China successfully.TD-LTE,as the evolution of TD-SCDMA,will be operated in the future.Therefore,the two systems may coexist in some area.Accordingly,the inter-system interference caused by coexistence would degrade the performance of both.In this paper,minimum coupling loss(MCL) method is adopted to analyze the coexistence interference.We also calculate the isolation requirements,and investigate the antenna installation method,which can reduce the intersystem interference effectively.


Background: Immune checkpoints inhibitors (ICIs) are widely used in various therapy of tumors. With the increasing usage of them, immune-related adverse events (irAEs) have been known and become common events, especially in the dermatologic system. However, the rare and severe immune-related cutaneous adverse events (irCAEs) still lack enough knowledge. Case presentation: We described a rare case of Steven-Johnson syndrome (SJS) induced by pembrolizumab in an advanced squamous non-small cell lung cancer (NSCLC) patient. SJS is a rare irCAE that could happen at any time after immunotherapy while this case happened from the 3rd day. The patient had influence-like symptoms and several mucous lesions including oral, eye, and skin. With a gradually severer condition, a stoss therapy of intravenous immunoglobulin (IVIG) had a mild effect. It was a long process and failed to respond to usual dermatologic treatment. Conclusion: We share this case in order to enhance clinicians' ability to early recognition and diagnosis in severe irCAEs. Early recognition and appropriate management are important to evade the termination of immunotherapy. Such severe irCAE should be paid more attention to in clinical medicine when using ICIs.


Two-dimensional modeling of loading during the formation of the Idaho-Wyoming thrust belt shows that regional isostatic compensation by flexure of an elastic lithosphere is sufficient to control the formation of a foreland basin. The flexural rigidity of the lithosphere is inferred to have been approximately 1023 Nm (1030 dyne cm), on the basis of palinspastic comparison of predicted downwarping, due to the thrust plate loads, to the shape of the sedimentary wedge on the west side of the Cretaceous Western Interior seaway. Erosion of part of the uplifted thrust plates redistributed the load, depositing it farther to the east, thereby causing subsidence over a much wider area than could have been accomplished only by the loading by thrust plates. Paleotopography after major Cretaceous thrust events was calculated. The resulting mountainous terrain, gentle alluvial plain, and flat sea floor correspond well with the topography of the modern foreland thrust belt and basin system in the Andes of South America and to paleogeographic reconstructions in the western United States thrust belt. Topography is controlled by the subsurface geometry of the thrust faults, particularly the positions of ramp zones, and by isostatic subsidence.


An icosahedral quasicrystalline phase was confirmed as a primary precipitation phase in melt-spun Zr70Ni10M20 (M=Pd, Au and Pt) ternary metallic glasses with two-stage crystallization process. The onset temperature of the transformation from amorphous to icosahedral phase are 687 K for Pd, 754 K for Au and 783 K for Pt at a heating rate of 0.67 K s−1. The size of the icosahedral particles is in the range of 5–20 nm. The second crystallization reaction results in the formation of Zr2Ni+Zr2Pd and Zr2Ni+ZrPt phases in the Zr–Ni–Pd and Zr–Ni–Pt alloys, respectively, and Zr3Au phase in the Zr–Ni–Au alloy through a single exothermic reaction. The formation of nanoscale icosahedral phase indicates the possibility that icosahedral short-range order exists in the glassy state.


Background:
 Each year in the U.S, 60,000-100,000 people die of venous thromboembolism (VTE), but little is known about mortality and causes of death over the long-term after VTE.

 Hypotheses:
 VTE, especially cancer-related VTE, is associated with poor long-term survival. Cancer and circulatory diseases are the main causes of death after VTE.

 Methods:
 Atherosclerosis Risk in Communities (ARIC) cohort participants, free of VTE at baseline (n=15,516), were followed (1986-2019) to identify first-time VTE (classified as unprovoked, cancer-provoked, or other-provoked, e.g., after surgery) and deaths. ICD10 codes were used to define cause of death. The proportion who died for each cause of death after first VTE, by type of VTE, was tabulated. Hazard ratios (HRs) of death by type of VTE were estimated with Cox proportional hazards models adjusted for age, race, gender, and pre-baseline cancer. Survival rates were visualized by adjusted survival curves.

 Results:
 Over a maximum follow-up of 33 years, 1,076 participants had first-time VTE; 441 were unprovoked, 271 were cancer-provoked, 364 were other-provoked. Mean age at first VTE was 74. After unprovoked VTE, 37% died of circulatory diseases (excluding VTE) and 13% of cancer. Those values were 35% and 13% for other-provoked VTE. By contrast, for cancer-provoked VTE, 80% died of cancer and 10% of circulatory diseases (excluding VTE). In the
 Figure
 , those with VTE had poorer long-term survival than 14,400 participants without VTE, and cancer-provoked VTE had the highest mortality. Overall, the HR of death was 2.75 (95% CI: 2.49-3.05) for those with vs without VTE. Those with cancer-provoked VTE had the highest HR, 10.02 (95% CI 8.81-11.40), but those with unprovoked and other-provoked VTE also had higher mortality than those without VTE.

 Conclusions:
 In this study, long-term survival after VTE was poor. Apart from cancer-provoked VTE, circulatory diseases were the primary causes of death after VTE. Optimizing cardiovascular prevention could improve long-term survival of patients with VTE.


On Monday 23rd Sept 2013 Scott Farmer started the biggest challenge of his life - running from Scarborough Pier to the Eric Morecambe statue, Morecambe, ...


Human resources play an important role in the process of im- proving labor productivity in an enterprise. In the business entity is required quali ed human resources in its work, the placement of the source human resources appropriate to the job completion rate is necessary in order to obtain optimal results. there is a problem placement of employ- ees in KENEZ SALON. Solved by optimization hungarian method assignment method. in the placement process can be calculated based on the total employees in doing the job and accuracy of assigned employees by the eective working time. With the results obtained are saving processing time is 20 minutes.


This paper reports the synthesis of a solid-form geopolymer by ball-milling of raw materials of varying compositions together in the solid state. This resulted in the formation of ready-to-use geop...


This paper reports the results of modeling of the electrical characteristics of SWIR/MWIR p-i-n photodiodes with type II InGaAs/GaAsSb multiple quantum wells (MQWs) as the absorption region. Bulk based model with the effective band gap of the type-II quantum well structure has been used in modeling of the experimental data. We investigated the dark current contributing mechanisms that are limiting the electrical performance of the diode. The quantitative simulation of the I-V characteristics shows, that the 200K to 290K performance of InGaAs/GaAsSb photodiodes is dominated by generation-recombination processes at the small reverse bias (-5V~0V). Above -10V, the trap-assisted tunneling current and direct tunneling current begin to dominate.


In their seminal paper on evolutionary game dynamics, Taylor and Jonker (1978) noted that even the powerful concepts of evolutionary stability and game dynamics then available failed to cope with the problem of the evolution of cooperative behavior between selfish individuals. Taylor and Jonker concluded that a new kind of game theory would be necessary to tackle this problem. Robert Axelrod's The Evolution of Cooperation now fills the gap. In fact, this book provides the analytic theory of games, as well as the biological and social sciences, with a wealth of novel concepts, mathematical theorems, and empirical data from computer experiments.