Background: We evaluated the recently marketed UriDoctor analyser (DFI Co., Ltd., Korea) for urinalysis and measurement of microalbumin and creatinine in urine. Methods: The precision within and betweenruns was evaluated using commercial control materials. The comparison evaluations were performed using patient urine samples. Urine dipstick tests for blood, bilirubin, urobilinogen, ketones, protein, nitrite, glucose, pH, specific gravity, and leukocyte esterase were performed with UriDoctor using CYBOW10 strips (DFI Co., Ltd., Korea) and with AX4030 using Aution Sticks 10EA (Arkray Inc., Japan), and the results were compared. Additionally, tests for microalbumin and creatinine were performed with UriDoctor using CYBOW2AC strips and with the Cobas c501 system (Roche Diagnostics, Germany), and the results were compared. Results: The within-run and between-run precisions for urinalysis using UriDoctor were both 100%. The concordance rates and concordance rates including ±1 grade between UriDoctor and AX4030 were as follows: blood (90%, 100%); bilirubin (97%, 100%); urobilinogen (98%, 100%); ketones (92%, 100%); protein (83%, 100%); nitrite (100%, 100%); glucose (85.0%, 100%); pH (58%, 94%); specific gravity (32%, 80%); leukocyte esterase (89%, 93%). The concordance rates between UriDoctor and the Cobas c501 system were as follows: microalbumin (71%); creatinine albumin-creatinine ratio Conclusions: UriDoctor showed good precision. There was significant agreement between the results of UriDoctor and AX4030, except for pH and specific gravity. The albumin-creatinine ratio showed relatively low specificity and high sensitivity; therefore, it would be more suitable for screening patients. The performance of UriDoctor when used with CYBOW10 and CYBOW2AC strips was satisfactory for clinical application. (J Lab Med Qual Assur 2014;36:190-195)


Amiodarone is the most effective antiarrhythmic drug, but its long-term use is limited by organ toxicity. We studied the rates of and factors associated with permanent amiodarone discontinuation in clinical practice.

 An ongoing prospective single-centre registry-based observational study included consecutive amiodarone-naïve patients treated for cardiac arrhythmias in a university hospital between January 2015 and December 2017. Amiodarone was administered in loading doses of 400–800 mg daily for 1–2 weeks, followed by 200–400mg daily for 4–8 weeks and 200mg daily or 1000mg weekly thereafter.

 Of 1032 patients (mean age 61.5±11.4 years), 30.0% were females, and amiodarone was used for atrial fibrillation (AF, n=657, 63.7%), atrial flutter (n=187, 18.1%), other supraventricular arrhythmias (n=118, 11.4%), premature ventricular beats (n=239, 23.2%) or ventricular tachycardias (n=236, 22.9%). The most prevalent comorbidities were hypertension (n=761, 73.7%), coronary artery disease (n=283, 27.4%), heart failure (n=197, 19.2%), chronic kidney disease (n=266, 25.8%) and diabetes mellitus (n=196, 19.0%).
 Amiodarone was permanently discontinued due to its side effects in 103 patients (10.0%), physician's fear of complications in 73 (7.1%), patient preference in 4 (0.4%) or for miscellaneous reasons in 6 (0.6%). In another 161 patients (15.6%), the discontinuation was due to catheter ablation of index arrhythmia (n=90) or progression to permanent AF (n=71). On multivariable Cox-regression analysis, physician decision was significantly associated with amiodarone discontinuation (HR 4.2; 95% CI 3.3–5.5, p<0.001) along with the drug side effects (HR 3.0; 95% CI 2.4–3.8, p<0.001).
 Overall, amiodarone was permanently discontinued 347 patients (33.6%), after mean 21.4±25.2 months of treatment (median 13.0, IQR 203). The mean time to discontinuation was significantly shorter in patients with drug discontinued due to physician's decision (16.5±15.9 vs 22.7±26.9, p=0.013) and slightly longer in those with amiodarone side effects (24.9±25.8 vs 19.9±24.8 months, p=0.093) than in others. Side effects resulting in permanent amiodarone discontinuation were: hyperthyreosis (66, 6.4%), hypothyreosis (19, 1.8%), liver injury (5, 0.5%), bradycardia/AV block (9, 0.9%), QT prolongation (2, 0.2%) and corneal deposits (4, 0.4%). Pulmonary toxicity was not observed among study patients.

 Our study showed that permanent amiodarone discontinuation in contemporary practice was due to its side effects in 10% of amiodarone-treated patients, occurring after a mean 2-year treatment course. The most prevalent side effect was thyroid dysfunction, whilst the prevalence of proarrhythmic effect was low. Notably, physician's fear of complications (which may not always be justified), was an independent driver of permanent amiodarone discontinuation. More data are needed to inform optimal amiodarone use in daily practice.


Orthogonal Arrays allow us to test various levels of each factor and balance the different factors so that we can estimate interactions as well as first order effects. There is a trade-off between how well we can sample different levels of each factor and how many interactions we are able to estimate. This paper describes one method to mitigate this trade-off. This method will allow us, with n observations, to sample n levels of each factor and minimize the correlation between the estimates of first order terms and their interactions.


Background: The movement of the train in an insulated space with the natural atmospheric pressure is accompanied by energy losses for unproductive work to overcome the profile air drag from the front and rear surfaces of the vehicle. At the same time, there is also a considerable increase of energy costs for overcoming the growing force of oncoming air drag. In order to exclude these energy losses, it is proposed to organize synchronous and volume-balanced pumping of air from the front part of the tube transport and injection of the air into the back part of the tube transport.
Aim: To develop a method of organising air exchange inside the tube transport, which will ensure the reduction of air resistance to the movement of the train.
Methods: The proposed developments are based on well-known national and foreign designs of high-speed tube transport systems, the results of a comparative analysis of tube transport with varying degrees of air pumping (backing vacuum and hard vacuum), taking into account the experience of redistributing the residual air volume in the Hyperloop and TransPod tube transport systems. The operating parameters of the compressor units that pump air into the internal cavity of the tube when the train is in motion is regulated on the basis of process models of gas dynamics.
Results: A new method and device has been developed for reducing the air drag to the movement of the train by forced air exchange, which provides for the redistribution of air from the front to the rear of the transport tube relative to the vehicle travel direction. For the air redistribution, the external air exchange unit, consisting of air ducts, compressor units, gate valves, and air collectors is used. The process of external air exchange takes place only when the vehicle is in motion, for the movement of the vehicle no prior air exhaust is required. The air redistribution is controlled taking into account the speed of the train, its location in the tube, the design features of the tunnel and vehicle. The speed of the train for each segment of the speed section is normalised depending on the actual performance of the components of the air exchange system. Modes of operation of the compressor units must ensure synchronous redistribution of air from the front to the rear of the tube. The movement of a vehicle along a tube with normal atmospheric pressure in the internal cavity provides conditions for the safe transportation of goods and passengers.
Conclusion: The developed method is designed to reduce the force of air resistance when the train is in motion inside the airtight tube without creating vacuum. The presented developments have good prospects for use in projects of high-speed transport systems of both underground and underwater designs.


Introduction Chapter I. Cohomology with polynomial growth and completion theory 375 §1. Cohomology with polynomial growth 378 §2. Cohomology with algebraic division and polynomial growth.. 406 §3. Application to analytic de Rham theory 425 Chapter II. Uniform estimations on homomorphisms of coherent sheaves 432 §4. Uniform estimations with bound and algebraic divisions... 433 §5. Proof of Lemma 4.1-Lemma 4.6 467 Appendix I. Elementary computations — 1 Chapter III. Polynomial growth uniform estimations for the structure sheaves of complex euclidean spaces 500 § 6. Cousin integrals and spectral sequences 501 §7. A sharpening of degeneracy theorem and polynomial growth uniform estimations 521 Appendix II. Elementary computations — 2


This paper presents details of an eigenproblem solution procedure for the efficient and accurate free vibration analysis of gyroscopic systems such as spinning structures. The procedure enables computation of the first few roots and vectors without having to compute any other. While structural discretization is achieved by the standard finite element method, eigenproblem solution of the resulting equations is effected by a newly developed progressive simultaneous iterative (PSI) method. Numerical solution of relevant example problems re presented which are compared to those obtained by ther existing analysis techniques, testifying to substantial gains in the efficacy of the newly developed solution algorithm. Copyright © 2001 John Wiley & Sons, Ltd.


Proton pump inhibitors are widely used for Gastro Esophageal Reflux Disease (GERD) treatment. This prospective double blind randomized cross over study was carried out in the Department of Gastroenterology, BSMMU from June 2007 to May 2008 to assess the efficacy of Immediate-release omeprazole (IR-OMEP) & Delayed-release Omeprazole (DR-OMEP) in relieving symptoms & healing of oesophagitis in GERD. All patients who fulfilled the inclusion criteria underwent upper gastrointestinal (UGI) endoscopy to be lebelled as nonerosive and erosive GERD. Among total 69 patients, 43 (62.3 %) had nonerosive and 26 (37.7 %) had erosive GERD. Patients were divided into group A (35) and group B (34) who received group A drugs (20 mg IR-OMEP bd) and group B drugs (20 mg DROMEP bd) from day 1-14 respectively. Then drugs were crossed over (group A: 20mg DR-OMEP bd; group B: 20 mg IR-OMEP bd) from day 15-28. Improvement of heartburn, regurgitation in each group were assessed in every week, during drug cross over and at the end and then compared between two groups. There was no significant difference in relieving heartburn and regurgitation between IR-OMEP and DR-OMEP either in erosive or nonerosive GERD (P>0.50). Patients with erosive GERD underwent UGI endoscopy at the end of treatment to see healing of esophagitis. Study showed significant healing of oesophagitis in group A after 4 weeks than group B (14%) (P<0.05) but there is no superiority of IR-OMEP over DR-OMEP in relieving symptoms of GERD. Faridpur Med. Coll. J. Jul 2016;11(2): 67-73


This supplemental note o¤ers a general version of Proposition 1 in "Testing Predictive Ability and Power Robusti…cation (TPA_PR, hereafter)". To de…ne its scope, we need to introduce some notation. Let (M, ) be a complete metric space with metric on M M; and let l1(M) be the space of bounded functions onM; equipped with the sup norm jj jj1 : jjf jj1 supm2Mjf(m)j for all bounded functions f onM. For any functions f; g 2 l1(M); we write f g if f(m) g(m) for all m 2M: We turn to the hypothesis testing: for a given map d 2 l1(M);


Many organizations operate multiple business models concurrently. Yet, we know little about the opportunities and challenges when managing a business model portfolio in one organization. In this symposium we have assembled one theoretical and one empirical paper that address the opportunities of managing a business model portfolio for diversified firms. Another theoretical paper and a simulation explore the challenges presented by portfolio management within a single organization, including dealing with complexity and interdependencies within the business model portfolio. Following the presentations, two high-profile scholars, Tomi Laamanen and Chris Tucci, experts in corporate strategy and business model research, will serve as discussants to provide both theoretical and practical suggestions and lead an interactive group discussion." Business Model Portfolio Diversification Presenter: Paolo Aversa; Cass Business School, City, U. of London Presenter: Stefan Haefliger; Cass Business School, City, U. of Lo...


Abstract The Fezzan Project is investigating the last 10,000 years of human settlement, landscape evolution and climatic change in the Germa region in southern Libya. The second season in February–March 1998 comprised interdisciplinary research in archaeology and geography, centred around excavation and survey work carried out at the site of Old Germa. To date, three phases of mud brick buildings have been partially explored. In addition, wider geomorphological study and archaeological survey and fieldwalking were carried out elsewhere in the Germa/Twesh oasis and around el-Hatiya. Numerous sites were discovered, including a new hillfort of Zinchecra type and several valley centre 'villages' of Garamantian/Roman date. Artefactual studies were carried out on pottery and lithics, animal bones and seeds. Further work on the subterranean irrigation features, the foggaras, have confirmed their pre-Islamic origins.


In this paper, a novel Ultra-wideband notch antenna is proposed with a working bandwidth of 3 ~ 11 GHz, which is used trapezoidal microstrip line feed. The dimensions of the antenna is 32 × 25mm2, and the patch has a hexagonal structure. In order to achieve ultra-wideband characteristics of 3 to 11 GHz, impedance matching is achieved by using a trapezoidal microstrip feed line. Using a half-wavelength resonance principle, a half-wavelength U-shaped slot is etched on the hexagonal patch to form a notch in the Wireline Local Area Network (WLAN) band (5.15 ~ 5.85GHz). Introduce an improved single complementary split resonant ring (CSRR) at the trapezoidal microstrip feed line, and add an H-shaped slot at the center of a single split complementary resonant ring. This structure can form a two-stage resonant circuit, achieving double notch characteristics in the downlink frequency band of the C-band communication satellite transmission signal (3.7 ~ 4.2 GHz) and the X-band satellite communication band (7.9 ~ 8.4GHz). By adjusting the size of the slot and the width of the slot, the center frequency of the notch band and frequency band of the notch band can be changed, so the adjustment of the notch is realized. Finally, the antenna achieves bandwidth suppression in 3.70–4.49GHz, 5.03–6.15GHz and 7.52–8.43GHz bands, and the peak points are −0.1dB, −1.25dB and −0.68dB, respectively. The anti-jamming performance is good. Compared with the method of forming double notches mentioned in the previous literature, the design method is simpler, which provides new idea for realizing multi-notch structure in the future.


In recent years, migration has been modelled within e perspective of social networks. Models are bas ed on the idea that migration flows are influenced by the social networ ks where the agents operate. In this work we use a Multi-Agent System to simulate social networks of migrants and analyse the impact of the structure of these networks in t he flow of migrants. The model we propose uses information of a IPUMS da tabase of immigrants in the United States. We focus ed in four different countries of origin: Germany, Mexico, Por tugal and China and in six variables: age, educatio n l level, income, number of people in the household, labour status an d number of individuals in the social network of th e agent. We have analysed four important measures of network structu e: density and three measures of degree centraliza ion: input, output and general. Results indicate that Mexicans have hi gher input and general degree centralization, meani ng that their networks have higher levels of influence of the agents. We c oncluded that the agents that stay in the U.S. (and do not go away to their country of origin), have network connections that a re weaker than those of other agents.


This paper proposes a method of signal analysis for a semi-active suspension isolation system. A semi-active suspension isolation system is an efficient equipment for vibration isolation and noise reduction in a car. In order to achieve a good vibration isolation effect, it adjusts its damping characteristic according to the excitation signals caused by different road conditions. Thus the key technique of the control of a semi-active suspension isolation system is to classify the excitation signals and analyze them quickly in time. This paper puts forward a signal processing method for these signals. At first, these signals are subdivided into three types, the stationary signal, the non-stationary signal and random signals. Subsequently, it uses the short-time Fourier transform (STFT) to handle them with different window functions in order to find the main frequency of the signal. Especially, the dynamic trend of the main frequency has to be considered for non-stationary signals. The two main parameters of the main frequency of the excitation signal, namely the position and the amplitude, will be obtained by the signal analysis. Then the control system can use them to give the best damping ratio for the damper. Finally, the method is used in a two-stage semi-active vibration isolation system to verify its effect. The experimental results show that it can analyze the signal exactly in time, and obviously enhance the vibration isolation performance of the semi-active suspension isolation system.


The use of chemicals in agriculture has been increased especially in the second half of lastcentury until the present day and is a constant theme of study and debate in the light of the risksof contamination of water, soil, atmosphere and human imminent when used interchangeably . Inthe book The Silent Spring of RACHEL CARSON, 1962, showed how DDT penetrated the food chainand accumulate in the fatty tissues of animals, including humans, with the risk of causing cancerand genetic damage. The chemicals used in agriculture are classified as toxicology in classes thatrange from I (extremely toxic) to IV (slightly toxic), toxicological evaluation itself, environmental,physical and chemical characteristics and toxicity to non-target organisms. The ecotoxicology ofthese products from an environmental standpoint can be determined through studies thatdetermine the environmental performance of the product on the biodegradability, sorption(sorption) and mobility. Our history records agronomic moments of extremes and even disasters by improper use as well as some advances in reducing the use of pesticides, use of alternativepractices, discovery of less aggressive products, integrated management of adverse factors (pests,diseases and weeds). To reduce risks should have the appropriate employment of such productsand be prevented for any accidents with them and the incessant search for information in thismatch the challenge of food production with sustainable agriculture.


Assessment of the blood vessel morphology in retinal fundus images is an indispensable method to diagnose diseases such as diabetic retinopathy and glaucoma. Ophthalmologists commonly evaluate fundus images with manual planimetry vessel extraction, which represents a clear bottleneck and is prone to human errors. Therefore, an automatic vessel segmentation tool can help clinicians perform this task, thus, improving the accuracy of the diagnosis. This work proposes a fully automatic segmentation framework based on the Chan-Vese active contouring algorithm for defining blood vessels in retinal images enhanced by matched filtering. Moreover, custom pre-processing workflows facilitate the subsequent segmentation depending on the analyzed images' intensity-based characteristics. The effectiveness of the proposed method was evaluated on the benchmark dataset STARE. Our framework outputs resemble much closer the ground truth images than other segmentation strategies, achieving an average accuracy of 94.37% and a Dice Similarity Coefficient of 0.7441.


NE of the first tasks of the government of the ew province [of Upper Canada was to fulfil the promise of the Constitutional Act concerning the change in. land tenur . This act provided that in Upper Canada land would be granted in free and common socage and that persons who already held land on certificates of occupation, which promised them grants on seigneurial tenure, would, on surrendering their certificates, receive patents in free ,and common socage. The exchange of certificates for patents proved to be a complicated undertaking and one that was not completed in Simcoe's day. It took time to devise a method of survey and a form of patent which met the requirements of the Constitutional Act and of the royal instructions and which also satisfied the people of Upper Canada. The chief difficulty was that the clergy reserve clauses of the act complicated and delayed the adoption of a method of surveying new townships. In Lower Canada the Land Committee of the Council proposed that the reserves be set aside in compact blocks in the corners of townships except in river and lake townships where the reserves hould be relegated to the rear concession, 1 but the home government' objected to these methods as contrary to the act and unfavourable to the reserves. In Upper Canada the Land Committee adopted the famous chequered plan devised by D. W. Smith. Smith's plan aroused unfavourable comment because it would prevent compact settlement, and petitions were sent to Simcoe asking for the Lower Canada system of reserves in the corners. 2 They were rejected, the home government approved the chequered plan, and Lower Canada was also ordered to adopt it. In Upper Canada the chequered plan was not deviated from except for those townships which had been fully or partially located before 1791. In such cases reserves were set aside in other townships or in blocks in the centre of townships, or in the rear concession. a Smith's chequered plan


This paper reports a new contact technology comprising antimony (Sb) co-implantation and segregation to reduce Schottky barrier height (SBH) and parasitic series resistance for N-FinFETs. Experiments with shallow Sb, Ge and As co-implantation in the source/drain (S/D) regions of SOI FinFET found that all three implant species significantly reduced extrinsic resistance. The Sb implant with a 5e13 cm-2 dose produced the best result with a 31% reduction of extrinsic resistance and a corresponding Ion increase of 19%. This optimum Sb implant is shown to reduce specific contact resistivity (ρc) below 10-8Ω-cm2 by decreasing the SBH and increasing the barrier steepness. Electrostatic control comparable to the reference device indicates no degradation in short channel effects for either Sb, Ge or As. This low ρc is promising to address key FinFET scaling issues associated with parasitic series resistance for the 14nm node and beyond.


The Author(s) 2018. Published by Oxford University Press on behalf of the European Public Health Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/ 4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. doi:10.1093/eurpub/cky196 . .. . . .. . .. . .. . .. . .. . .. . .. . .. . . .. . .. . .. . .. . .. . .. . .. . .. . . .. . .. . .. . .. . .. . .. . .. . .. . . .. . .. . .. . .. . .. . .. . .. . .. . . Opioid, antipsychotic and hypnotic use in end of life in long-term care facilities in six European countries: results of PACE


In the framework of topcolor-assisted technicolor(TC2) model, we study a neutral toppion production process $e^{-}\gamma\to e^{-}\Pi^{0}_{t}$ in this paper. Our results show that the production cross section of $e^{-}\gamma\to e^{-}\Pi^{0}_{t}$ can reach the level of several tens fb, and over $10^{3}$ neutral toppion events can be produced in the planned $e^+e^-$ linear colliders each year. Therefore, such a toppion production process provides us a unique chance to detect toppion events and test the TC2 model. On the other hand, the cross section of $e^{-}\gamma\to e^{-}\Pi^{0}_{t}$ is about one order of magnitude larger than those of some similar processes in SM and MSSM(i.e., $e^{-}\gamma\to e^{-}H$ in SM and $e^{-}\gamma\to e^{-}H^{0}(A^0,h^0)$ in MSSM). So, we can easily distinguish the neutral toppion from other neutral Higgs bosons in SM and MSSM.


The US. Department of Energy Headquarters established a performance assessment task team (PATT) to integrate the activities of DOE sites that are preparing performance assessments for the disposal of newly generated low-level waste. The PATT chartered a subteam with the task of comparing computer codes and exposure scenarios used for dose calculations in performance assessments. This report documents the efforts of the subteam. Computer codes considered in the comparison include GENII, PATHRAE-EPA, MICROSHIELD, and ISOSHLD. Calculations were also conducted using spreadsheets to provide a comparison at the most fundamental level. Calculations and modeling approaches are compared for unit radionuclide concentrations in water and soil for the ingestion, inhalation, and external dose pathways. Over 30 tables comparing inputs and results are provided.


The pollution sources for Shahu Lake were investigated and analyzed in detail in this paper.The resultswere shown as follows:① The Yellow river waste water and the surface runoff to the Shahu Lake were the two main pollution sources.② 20.00tons of total nitrogen and 3.04tons of total phosphors from Yellow river flowed into Shahu Lake in 2004 which occupied 57.7% of the total phosphorsand 50.4% of total nitrogen flowed into t Shahu Lake.③15.00tons of total nitrogen and 2.00tons of total phosphors in the farm water flowed into Shahu Lake in 2004,which occupied 37.9% of the whole total phosphorsand 37.8% of whole total nitrogen flowed into Shahu Lake.④11.99tons of total nitrogen and 1.93tons of total phosphors were output from the reed and fish harvest in 2004.On the basis of investigation and analysis of the pollution sources in Shahu Lake,several experience models on the base of water quality data were established and verified by the experimental data in 2004 respectively.The results showed that the OECD model could be used to predict the TN concentration and TP concentration in Shahu Lake.So the OECD model was selected as the phosphorus and nitrogen model of Shahu Lake.Using the model,five countermeasures of controlling pollution were comparedand some better countermeasures were suggested finally.


A detailed description of the mouthpart morphology is provided for Axius stirhynchus Leach, Calocaris macandreae Bell, Upogebia deltaura (Leach) and U. pusilla Petagna. The distribution of setae on the mouthparts of three additional species of thalassinidean mud-shrimp, Callianassa subterranea (Montagu), Jaxea nocturna Nardo and U. stellata (Montagu), is also given. Particular attention was paid to the mouthpart setal fringes, where major differences were observed in setal type, inter-setal distances and inter-setule distances. The mouthparts of the three upogebiid species examined were characterized by plumed setae with very small intersetal distances. The mouthparts of the other four species of thalassinidean were dominated by more robust serrate setal types. The setal screens of the upogebiids were often made up of a single setal type, whereas those of Calocaris macandreae and Axius stirhynchus were often comprised of a number of different setal types. The observations made for Callianassa subterranea ...


We investigate strategies for selection of databases and instances for training cross-corpus emotion recognition systems, that is, systems that generalize across different labelling concepts, languages and interaction scenarios. We propose objective measures for prototypicality based on distances in a large space of brute-forced acoustic features and show their relation to the expected performance in cross-corpus testing. We perform extensive evaluation on eight commonly used corpora of emotional speech reaching from acted to fully natural emotion and limited phonetic content to conversational speech. In the result, selecting prototypical training instances by the proposed criterion can deliver a gain of up to 7.5 % unweighted accuracy in cross-corpus arousal recognition, and there is a correlation of .571 between the proposed prototypicality measure of databases and the expected unweighted accuracy in cross-corpus testing by Support Vector Machines.


Values of 613C and levels of phosphoenolpyruvate carboxylase and ribulose 1,5-bisphosphate carboxylase/oxygenase were ana- lyzed in segments from the fourth leaf of young maize (Zea mays L.) plants. The 613C values became significantly more negative from the base to the tip of the leaves. Phosphoenolpyruvate carboxylase levels and ribulose bisphosphate carboxylase levels both increased from the base to the tip. The principal effect of phosphoenolpyruvate carboxylase levels or 513C should arise through its effect on the carboxylation/diffusion balance in the mesophyll. In this case, 513C values should become more negative as phosphoenolpyruvate carboxylase levels increase, unless there are offsetting changes in stomatal aperture. The principal effect of ribulose bisphosphate carboxylase/oxygenase on 513C should occur through its effect on the extent of leakage of CO2 from the bundle sheath cells. In this case, 513C values should become more positive as ribulose bisphosphate carboxylase levels increase. Accordingly, the variation in 613C values seen in maize leaves appears to be the result of variations in the level of phosphoenolpyruvate carboxylase.


Distributed Constraint Satisfaction Problems (DisCSP) have long been considered an important area of research for multi-agent systems. This is partly due to the fact that many real-world problems can be represented as a constraint satisfaction problem and partly because real-world problems often present themselves in a distributed form. The agent paradigm is particularly well suited to handling problems of this type. Agents are easily distributable and have both encapsulated state as well as autonomous reasoning capabilities. This allows them to work together to solve problems that cannot be completely centralized due to security, dynamics, or complexity. In this paper, we present an algorithm called asynchronous partial overlay (APO) for solving DisCSPs that is based on a mediated negotiation process. The primary ideas behind this algorithm are that agents, when acting as a local mediator, partially centralize a subproblem of the CSP, that these partially centralized subproblems overlap, and that agents increase the size of their subproblems along critical paths within the CSP as the problem solving unfolds.


Prostate cancer is the commonest male cancer. A number of different methods have been used to make an early diagnosis. Histological confirmation is vital for both diagnosis and management planning. Transrectal ultrasound is established as a safe and convenient tool for assessment of the prostate and ultrasound guidance has been shown to be a useful adjunct in obtaining a tissue diagnosis. A brief review and description of our technique is given.


Four aspects can be used for reference are clarification of the Sports Education media conception, significant meaning of theoretical learning, study route choice and establishment of study/learning community. The purpose of this paper is to sort and describe, reflect and use for reference, in order to widen the view of Chinese theoretical study on Sports Education media.


FDA has approved cariprazine (Vraylar, Allergan and Gedeon Richter Plc.) for the treatment of schizophrenia and bipolar I disorder in adults.


The main purpose of this paper is to understand the different results of using the Markowitz Model and Full Index Model to derive the return and risk level of the optimal metaverse portfolios at the side of traders, and how different constraints affect the return and risk portfolios. The method used is Markowitz Model and the Full Index Model. In the paper, the detailed calculation methods are shown, and the results are generated by Excel. If you prefer to use a computer language other than Excel. The finding is Full Index Model always gave a lower rate of return at the same level of risk, and constraints always brought negative effects to the return of portfolios. Therefore, it suggests using the Full index Model to derive optimal portfolios and invest without any constraint.


The classical theorem of Vizing states that every graph of maximum degree $d$ admits an edge coloring with at most $d+1$ colors. Furthermore, as it was earlier shown by Kőnig, $d$ colors suffice if the graph is bipartite. We investigate the existence of measurable edge colorings for graphings (or measure-preserving graphs). A graphing is an analytic generalization of a bounded-degree graph that appears in various areas, such as sparse graph limits, orbit equivalence and measurable group theory. We show that every graphing of maximum degree $d$ admits a measurable edge coloring with $d+O(\sqrt{d})$ colors; furthermore, if the graphing has no odd cycles, then $d+1$ colors suffice. In fact, if a certain conjecture about finite graphs that strengthens Vizing's theorem is true, then our method will show that $d+1$ colors are always enough.


Comunicata Scientiae is a scientific journal created at the Campus "Prof.a Cinobelina Elvas" of the Federal University of Piauí in 2009, which had the first issue published in 2010.Initially, the journal aimed to disseminate the knowledge generated by the scientific community through the publication of research results and new scientific proposals unpublished and relevant to the Agrarian and Environmental Sciences. With this proposal, the journal had a significant growth in the proposed knowledge areas (Agrarian and Environmental Sciences) and it was indexed in the main databases of the world as SCOPUS (Elsevier), obtaining SJR already in 2011 of 0,187, a value that is currently 0.372, which includes it in the second best category of SCOPUS, the Q2...


Triazole resistance in the airborne human fungal pathogen Aspergillus fumigatus is a significant human health problem as the environmental use of triazoles has selected for cross-resistance to life-saving clinical triazoles in medicine. Despite the environment being well established as a source of triazole resistant A. fumigatus spores, the aerial transmission from the environment to patients remains unclear. This is mainly due to the lack of an affordable, reliable, and simple-to-use method for wide-scale environmental air sampling. Previous methods were ineffective in capturing sufficient A. fumigatus colony-forming units (CFUs) to allow the quantitative assessment of aerial triazole resistance fractions. Here we show that 14 days of exposure of sticky seals to the air along with selectively culturing colonies directly from the seals proved key for increasing CFUs per sample. We also tested the use of delta traps for passive outdoor spore capture and show that together with the sticky seals and selective culturing, they are a simple and effective tool for outdoor air sampling. We suggest the use of this cost-effective air sampling technique for wide-scale outdoor sampling to map resistance fractions, assess health risks, and pinpoint environmental resistance hot- and coldspots. Doing so will close the knowledge gap between environmental triazole resistance selection and the transmission to patients.


Rythmical changes in the transcriptional activity of embryo chromatin during development and maturation of grain of triticale (cv. MT-3) have been observed. The template availability and RNA polymerase (EC 184.108.40.206) 1 and II activities were high at the beginning of embryo development (20 to 30 days) and lowest at days 35 to 40 after anthesis, after which they increased to the end of maturation (60 days). Grains from three important periods of development (20, 40 and 60 days after anthesis; that is milk, wax and full ripeness, respectively) were used for germination, and chromatin was isolated from embryos and seedlings. A dramatic increase in the activity of both RNA polymerases and template availability was observed after 48 h of germination. The increase in template availability depended also on the ripeness stage of the grain used for germination.


The RPO algorithm is a recently developed tool in the area of reinforcement learning. And it has been shown to be very successful in several application problems. In this paper, we consider a robot-control problem utilizing a modified RPO algorithm, in which its critic network is adapted via RLS(Recursive Least Square) algorithm. We also developed a MATLAB-based animation program, by which the effectiveness of the training algorithms were observed.


The incidence of ovarian metastases at the time of peritoneal carcinomatosis, and the influence of such metastases on survival after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), are unknown.


As observed by variable temperature and pressure 13C NMR, the intramolecular scrambling of carbonyl ligands in Rh4(CO)12 and IrRh3(CO)12 is due to a merry-go-round process (3 μ2-CO ↔ 3 η1-CO) about any triangular face of the metal tetrahedron. Both cluster compounds have a negative activation volume on going from the bridged ground-state structure of C3v symmetry to an unbridged transition state, suggesting that bridged M−M distances are longer than unbridged M−M distances. Site exchange is faster in Rh4(CO)12 than in IrRh3(CO)12 where the apical position is occupied by an iridium atom. Density functional calculations on the bridged and unbridged forms of both cluster compounds have been made at two levels of approximation (LDA and GGA) including relativistic effects for Ir and Rh. LDA reproduces best the experimental distances and shows that opening bridges shortens the M−M bonds. The difference in volume of the bridged and unbridged forms of Rh4(CO)12, as calculated from Connoly surfaces, agrees fairly ...


In a preceding article, I showed that the average scores of girls exceed the average scores of boys in tests of intelligence applied in the elementary school. In the present article, I call attention to the fact that when the Army Alpha test was released for civilian use and applied to pupils in the secondary school, a sex difference again appeared, but this time in the reverse direction?the average score of high-school boys exceeded the average score of high-school girls. The same result?superiority of men?likewise appears in Army-Alpha scores from normal schools and colleges. Various explanations have been set forth for this outcome : in particular, it has been argued that less capable boys are more apt to leave the high school than are less capable girls, so that the difference simply reveals the existence and the amount of this selective agency. And again, it has been argued that the content of Army Alpha, originally designed as it was for use in the army, naturally favored the male sex, both in its inherent appeal and in its subject-matter. As I have never seen any serious attempt to analyze this situation, and as it holds a certain amount of theo retical interest, it occurred to me to make use of an opportunity to study the scores of this test in detail.


Chinese teaching consists of in-class teaching,after-class teaching,teaching in revision and teaching of composition. In in-class teaching,students are taught to find the focal and difficult points independently.In after-class teaching,students are allowed to choose the reading chapters and sections by themselves.In revision of the units,students are asked to compile the contents of evaluation.And in teaching of composition,students need to assign the subjects for compositions and revise them by their own. Autonomous learning helps the students become the real master of the class.


Real-time pricing (RTP) is a component of some demand response programs (DRPs) in electricity markets. This paper proposes a real-time price-based demand response management model for heat and power consumers. In the proposed DRP, the responsive electrical load can vary in different time intervals. Real-time price risk can be shared among market participants sensibly by implementing several RTP hedge contracts. In this context, supply sources include energy from the real-time market, self-production facilities, as well as RTP hedge contract instruments. The model is introduced for electricity consumers equipped with combined heat and power systems, power-only unit, boiler unit, and heat buffer tank. Optimal hedging strategies, including hedge contract choices and hedged load percentages, can be acquired by solving the model. The proposed model makes it possible to achieve minimum energy cost while considering uncertainties in real-time electricity prices. The price uncertainty is addressed through robust optimization for minimizing the worst case electricity and heat demand procurement cost while flexibly adjusting the solution robustness. Numerical simulations are provided, which confirm the applicability and effectiveness of the proposed model.


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Forecasting about Indian market has always been interesting and topic of discussion among analyst and researchers. With the arrival of machine learning and artificial intelligence the race is now becoming the competition with best algorithms to be used and give investors more profit. In past years prediction was only based on experience and daily headlines of business newspapers but now it depends on various international, national and political economic factors and the sentiments and reaction of people over the issues. With the growing power of social media, the game in market over this also changed now with the help of sentiment analysis over social media we can determine the mood of investors over the news. In the present scenarios you can divide two categories for the prediction strategies one is the time series analysis of stocks and the second is artificial intelligence property over the market. AI property contains multi-layer perception, SVM, naive Bayes , back propagation,CNN,LSTM, RNN etc during this we have a tendency to came with plan of combination of each. Within the paper we have conjointly covers the assorted challenges that are encountered while building prediction models. This whole module focuses on use of statistical analysis and conjointly development of the sentimental analysis and to get better results. The LSTM has the advantage of analyzing relationship between time series knowledge through memory functions. The performance of the system is improved by combine efforts of time-series and sentiments with the LSTM prediction model.


ABSTRACT Introduction of DNA into normal and immunodeficient mice, alone or in complex with VP1 pseudocapsids, has been compared to DNA transfer by viral infection. Similar to natural infection and in contrast to plasmid alone, VP1 pseudocapsids efficiently introduced DNA, which remained for months in normal mice and possibly longer in B- and T-cell-deficient mice.


A method for performing an analysis of reservoir unidentified type Chalk River (CRUD, by its acronym) in a nuclear fuel rod, comprising: providing a nuclear fuel rod (28) with a layer of crud on an outside of the fuel rod; CRUD scraping of the fuel rod (28) with a scraping tool CRUD (10); where the scraping tool having a blade (40) with a rigidity that corresponds to a tensile shear tank provided CRUD. collecting CRUD flakes CRUD scraping tool; classifying the flakes CRUD in fractions of particles; and analyzing CRUD a scanning electron microscope,


The patient developed bacillary dysentery with frequent stools mixed with blood and mucus and was hospitalized in Sestre Milosrdnice Hospital in Zagreb, Croatia. Shigella sonnei was isolated from the stool specimen. The antibiotic susceptibility testing was performed by disk diffusion and broth microdilution method.


When the main 200 mm uPVC pipe to the clamshell water feature evidenced a leak, causing major water losses and ensuring the feature became non-functional, the only viable solution was to reline the pipe with Nu Flow technology, SA Leak Detection Distributors' David Wade tells Chantelle Mattheus.


The aim of this work was to test the comparative efficacy of four therapeutic modalities (self-exposure, self-exposure + Alprazolam, Alprazolam, and self-exposure + placebo) and also to determine the combined effects of self-exposure with Alprazolam and self-exposure with placebo in the treatment of agoraphobia without current panic. The sample consisted of 31 patients selected according to DSM-III-R criteria. A multigroup experimental design with repeated measures of assessment (pre-treatment, post-treatment and 1, 3 and 6-month follow-up) was used. The results indicated that there was a similar therapeutic improvement (in about 75% of the cases) between pre- and post-treatment in all therapeutic modalities, except for the Alprazolam group, where improvement did not take place, was rather weak or tended to fade as time passed. This improvement increased at the follow-ups in the self-exposure + placebo group, remained stable in the self-exposure group, and was irregular or fairly unpredictable in the self-exposure + Alprazolam group. There was a positive combined action between self-exposure and placebo and a negative interaction between self-exposure and Alprazolam. The highest relapse rate appeared in the therapeutic modalities where the active drug was administered. The intratreatment evolution was faster in the self-exposure group than in the others, but it tended to remain stable in the second part of the therapy. It is therefore concluded that the efficacy of self-exposure therapy may be the same if reduced to half the number of sessions. Finally, several topics that may contribute to future research in this field are commented upon.


The lower on state voltage drop along with high dv/dt, di/dt are some of the attractive features which makes MCT the most suitable device for motor drive application. A simple PWM scheme for half controlled MCT based AC/DC converter has been suggested. This pulse pattern has been optimised to contain simultaneously the minimum amount of input current and output voltage harmonics while at the same tune it is simple to implement as compared to similar other schemes. An analytical simulation has been carried out for this converter with DC motor load. The simulation results shows that the converter input performances like power factor and harmonic factor are relatively good. The output performance parameters like the ripple factor and peak factor are comparatively improved as compared to the published work. A MCT based converter with three phase input and the proposed control strategy has been assembled and tested in the laboratory to check the validity of its implementation. The overall converter performance has been found to be satisfactory. Some of the essential waveforms obtained from the experimental set up are shown in this paper.


ABSTRACT The frequency-modulated continuous wave (FMCW) ladar is a useful sensor for remote sensing applications and has been widely used in both the military and civilian fields for precise geospatial data acquisition. Typically, the FMCW-ladar signal is collected by use of the heterodyne detection through the dechirping so as to decrease the sampling rate commensurate with the bandwidth. In this manuscript, we proposed a novel scheme for processing the FMCW-ladar signal acquired through the simplified heterodyne detection, and the sampling rate was the same as that in the dechirp detection. Based on the time–frequency relation of the FMCW-ladar signal, two algorithms were proposed to post-process the echo acquired by the simplified heterodyne detection with the sub-Nyquist sampling rate. For the FMCW-ladar echo data acquired by the simplified heterodyne detection with the same sampling rate as in the traditional dechirp detection, the algorithms can achieve the unambiguous range image retaining the range resolution commensurate with the transmitted chirp bandwidth. The effectiveness of the scheme was validated by simulation and real data processing experiments. The capability of the proposed scheme provides an alternative for the FMCW-ladar system without use of the dechirp detection, which can benefit the future FMCW-ladar and microwave photonics radar applications in the remote sensing.


The invention provides a method for desulfurating and denitrating and recovering sulfur resource in a closed cycle way, comprising the following steps: 1, dedusting; 2, desulfurating and denitrating; and 3, recovering sulfur resource. The method can effectively solves the problems of the prior art such as difficult treatment of secondary products, secondary pollution, high working cost, single product and the like. According to market requirement, analysis reduction regeneration of desulfurated secondary products is fully utilized, aiming at treating waste with waste to serve multiple purposes, recovering the wasted sulfur resource in flue gas of fire coal with the lowest cost, improving the comprehensive added value of desulfurated secondary products and reducing working cost thereof, dedusting, desulfurating and denitrating, and recovering sulfur resource to realize long-term efficient working, self-sufficient closed cycle, resources and energy conservation, low energy consumption, and no waste water discharge and secondary pollution, thereby meeting the requirements of resource recovery and environmental management, and improving economic benefit and social benefit for enterprises.


It provides a method of making a nitride semiconductor device which makes it possible to obtain the GaN-based semiconductor layer of good quality from the foreign substrate. Method of manufacturing a nitride-based semiconductor device according to the present invention comprises the steps of growing the AlN nucleation layer on a substrate; Step of growing a GaN buffer layer on the AlN nucleation layer; Comprising the step of annealing the substrate, wherein the AlN nucleation layer is formed to have a large thickness less than the critical resilient thickness of AlN than a critical radius of a crystal nucleus of AlN, the GaN buffer layer is more than the critical radius of the crystal of GaN nucleus large and is formed to have a thickness less than the critical resilient thickness of GaN, the annealing time is L Gallium nitride, a semiconductor, a silicon substrate


The distributed data processing is an effective way to improve reliability, availability and performance of a database system. In this paper we will concentrate on data allocation problem with the aim to assure an optimal distribution of data in the process of the distributed database design in correlation with data fragmentation. Efficient allocation of fragments requires a balance between costs (storage, processing and transmission of data), performance (especially response time) and data distribution restrictions. The allocation of fragments is closely related to the replication of data from distributed databases. In addition, we analyzed the cost of fragmentation and replication.


The paper firstly introduces the situation of public transport of Shenyang.It points out that the presence of public transport public transportation network distribution is out of balance,the idea of bus priority bus is not deeply rooted,infrastructure of public transportation is lagging,the contradiction between the system and other issues is obvious.It puts forward that it strengthen funding,enhance vehicle renovation,strengthen bus lanes and signal management,strengthen infrastructure construction and improve service levels.


Networking is one of the most important issues currently facing the library and information community. The convergence of computing and communications technology is affecting the creation, management and use of information in ways not witnessed since the introduction of printing with movable type.


Abstract : This project was conducted to further develop the explosive cladding process and to use this process by joining pipes/tubes of metals that cannot be welded together by conventional methods. The project was diverted from the original plan to utilize a 'scarf-joint' transition joint of identical size pipes/tubes to development of a method of penetrating watertight bulkheads or decks with a pipe/tube having widely different properties. The emphasis was on penetrating aluminum bulkheads/decks with stainless steel pipes of sizes from 3/4 in. to 6 in. for Surface Effect Ship application. (Author)


The objective of this paper was to verify the use of variables included in the information Theory in study that deals with verbal interaction between AIDS patients and Nursing team. The results showed that the use of the variability calculation in data retained in SAVI matrix improves the statistical data and permit that the quality of the dialogue can be evaluated.


The construction of socialist ecological civilization(CSEC) with Chinese characteristics is not only the basic requirement of carrying out the scientific development perspective, but also the urgent need to solve the current prominent problems in China's economic and social development. The paper analyzes the connotation of ecological civilization, expounds the necessity of CSEC with Chinese characteristics, discusses the relationship between the China's political, economic, cultural and social construction and the construction of ecological civilization, puts forward the route selection of strengthening CSEC with Chinese characteristics through the guidance of the government, the promotion of the enterprises and the participation of the public. At last, it shows its future prospects on CSEC from thought establishment, moral formation and practice promotion.


Potato is one of the most cropped plants worldwide. Hundreds of different varieties are cultivated only in North America. Potato growers usually crop multiple varieties on their farms to answer the market demands for potato's specific physical properties. However, few pieces of information are available regarding the optimal management of irrigation across potato varieties. Knowing that modern potatoes share genetics similarities, the optimal irrigation comfort zone for the potato crop might be the same for different groups of varieties. This study evaluates the effect of precision irrigation thresholds on the potato yields of three varieties (Envol: very early, Kalmia: early, and Red Maria: mid-late) with different maturity classes. In a greenhouse, a soil matric potential sensor network used in combination with a precise irrigation system allows the identification of a common optimal precision irrigation threshold, allowing optimal yields for the three varieties. This paper presents the first identification of an optimal irrigation threshold, −15 kPa, shared by different potato varieties. The optimal irrigation threshold identified in this study is not dependent on the maturity class, plant height or tuber potential production. The determination of an optimal precision irrigation threshold will allow potato growers to adapt their farm management processes to integrate more sustainable water management practices as they will be able to irrigate a field with multiple varieties with the same threshold.


FIS‐2, a less oncogenic, immunosuppressive variant of the Friend murine leukaemia virus (F‐MuLV), was used to explore whether the differences in biological features were related to early virus dissemination rates or sites of replication. We found that erythroblasts were the primary target cells for both F‐MuLV and FIS‐2, while B‐ and T‐cells were infected later in the infection. Although FIS‐2 replicated to similar titres as F‐MuLV, we observed a delay in peak viraemia titre and in the number of virus‐positive cells in bone marrow and spleen. Studies including the chimeric viruses RE3 (FIS‐2 LTR with a F‐MuLV background) and RE4 (F‐MuLV LTR with a FIS‐2 background) indicated that the delay in dissemination was due to mutations in FIS‐2 LTR. The kinetics for early virus replication correlated with previously reported mean latency time for virus‐induced erythroleukaemia in mice inoculated as newborns and with the onset of immunosuppression in adult mice. In addition, F‐MuLV‐induced late immunosuppression coincided with signs of erythroleukaemia and persistent viraemia. FIS‐2 induced a more moderate late immunosuppression without persistent viraemia or signs of erythroleukaemia. Overall, our findings indicated that early viral replication is a prognostic factor in murine retrovirus‐induced pathogenesis.


Chopped cornstalks and cornstalk flour were: (1) subjected to an active methane-producing seed and (2) sealed in tap water without inoculation. Sometimes daily but usually at the end of 3, 5, 10, 20 and 30 days, analyses were made for: total solids, volatile solids, pentosans, cellulose, and lignin. The data are reported in 11 tables and 7 series of graphs. The flour fermented 43% more rapidly (gas production). The gas was 34 to 35% CO/sub 2/ and 55 to 59% methane. At the 3-, 20- and 30-day periods for the flour, loss of cellulose and pentosans accounted for 95% of the gas; for the chopped stalks only 75%. For the 5- and 10-day periods more cellulose and pentosans were decomposed than could be accounted for by the gas produced. The loss of cellulose and pentosan was greater in the flour and the loss of lignin greater in the chopped stalks. Incubation of corn stalks gives little promise of usefulness in pulp preparation but fermentation with an active seed does give some promise.


Using monochromatic photons from ({ital n},{gamma}) and ({ital p},{gamma}) capture reactions, the elastic scattering of photons was studied in the mass range {ital A}=181--238 and energy range {ital E}=8--18 MeV. It is shown that the {ital A} dependence of the enhancement of {ital E}1 strength located in the giant-dipole resonance as revealed by part of the photoneutron cross sections is confirmed by our photon-scattering data. The possibility is discussed that the concentration of {ital E}1 strength in the giant dipole resonance may be larger for closed-shell nuclei as compared to open-shell nuclei.


Recently, the UE has rejected the merger Alstom. Siemens claiming defense of the internal market. The article made some comparisons referred what the external competitors are doing, especially within the maritime sector. Also , it is treated the new and challenged scenarios in the shipping and shipbuilding sectors around the world when 2020 is approaching with the new rules on ships emissions.
Finally, the last is seen as a challenging opportunity for the engineers.


References 1 Pummi K, Malminen M, Aho H, et al . Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in in vitro differentiating keratinocytes. J Invest Dermatol 2001; 17 : 1050–1058. 2 Brander JM, Kief S, Grund C, et al . Organization and formation of the tight junction system in human epidermis and cultured keratinocytes. Eur J Cell Biol 2002; 81 : 253–263. 3 Perez-Moreno M, Jamora C, Fuchs E. Sticky business: orchestrating cellular signals at adherens junctions. Cell 2003; 112 : 535–548. 4 Aldaz CM, Trono D, Larcher F, et al . Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions. Mol Carcinogen 1989; 2 : 22–26. 5 Braga VMM. Cell–cell adhesion and signaling. Curr Opin Cell Biol 2002; 14 : 546–556. 6 Jamora C, Fuchs E. Intercellular adhesion, signaling and the cytoskeleton. Nature Cell Biol 2002; 4 : 101–108. 7 Eunkyung C, Paul WC, Charles AP, et al . Amphiregulin causes functional downregulation of adherens junctions in psoriasis. J Invest Dermatol 2005; 124 : 1134–1140. 8 Zhou S, Matsuyoshi N, Takeuchi T, et al . Reciprocal altered expression of T-cadherin and P-cadherin in psoriasis vulgaris. Br J Dermatol 2003; 149 : 268–273. 9 Alicia L, Leopoldo F, Alfredo A, et al . Altered morphology and distribution of cellular junction proteins in non-lesional psoriatic epidermis: an insight into disease severity. Arch Med Res 2006; 37 : 36–44. 10 Stockinger A, Eger A, Wolf J, et al . E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. J Cell Biol 2001; 154 : 1185–1196. 11 Elder JT, Fisher GJ, Lindquist PB, et al . Overexpression of transforming growth factor α in psoriatic epidermis. Science 1989; 4892 : 811–814. 12 Cook PW, Pittelkow MR, Keeble WW, et al . Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas. Cancer Res 1992; 52 : 3224–3227. 13 Piepkorn M. Overexpression of amphiregulin, a major autocrine growth factor for cultured human keratinocytes, in hyperproliferative skin diseases. Am J Dermatopathol 1996; 18 : 165–171. 14 Zheng Y, Peng Z, Wang Y, et al . Alteration and significance of heparin-binding epidermal-growth-factor-like growth factor in psoriatic epidermis. Dermatology 2003; 207 : 22–27. 15 Nakamura T, Kato Y, Fuji H et al . E-cadherin-dependent intercellular adhesion enhances chemoresistance. Int J Mol Med 2003; 12 : 693–700.


Although pseudoxanthoma elasticum with angioid streaks was first described as a syndrome by Groenblad and Strandberg, 1 the symptoms and signs were recognized and known by others before them. In 1889 Doyne 2 reported changes of the retina similar to those described later as angioid streaks. In 1892 Pflange 3 and Knapp 4 described such changes as angioid streaks of the retina. The first comprehensive description of the characteristic cutaneous lesions was that by Darier 5 in 1896. He described both the clinical and the histologic changes of the skin under the name of pseudoxanthoma elasticum. In 1904 Werther 6 called attention to the fact that pseudoxanthoma elasticum was a familial disease. Sugg and Stetson 7 reported the case of two sisters with pseudoxanthoma elasticum, angioid streaks and diabetes. Verhoeff 8 reported angioid streaks in a case of osteitis deformans. In his investigation of 22 cases of osteitis deformans, Terry 9


User rating platforms enable us to collect data on user opinions and model users' credibility and trustworthiness. However, malicious users give fraudulent ratings in order to artificially improve their own ratings, often for monetary gains. In this work we study the bitcoin-otc and bitcoin-alpha networks. These networks are modeled as directed weighted signed networks (WSNs) with users as nodes and time-stamped edges representing user trust ratings on the associated bitcoin exchanges. We investigate the temporal evolution of several network properties in these WSNs, especially fairness and goodness [1], with the goal of identifying fraudulent users.


Stroke constitutes one of the primary reasons for death and severe weakness that affects millions of people worldwide and has a significant chance of developing into a pandemic in the coming years. Early diagnosis and fast treatment decisions are crucial in preventing paralysis, brain death, and other severe consequences of this condition. ML algorithms have been widely used to diagnose, analyze, and predict this disease, but there are data quality difficulties because the resources utilized to obtain the data are spread across multiple institutions. Hence, the deep learning framework with CNN is demonstrated in this paper. This technique makes use of a multimodal stroke dataset that is accessible to everyone in the Kaggle repository. 6100 MRI images are gathered for this process. The collected images contain noise and are of bad quality. So, the Weiner filter is utilized for pre-processing phase to remove the noise. Then, the watershed technique is employed for the segmentation process. Subsequently, Lion Optimization Algorithm is utilized for extracting the features. Lastly, CNN has been applied for the classification. By validating the performance measures, the LOA-CNN technique seems to be higher than the current techniques. The results demonstrated that the presented method achieves precision, accuracy, and recall rates of 99.32%, 99.52%, and 99.67%, respectively.


Over time, multiple semiotic modes have contributed in different ways to the construction and exchange of cultural meanings in Tourism Discourse. This has required the analysis and understanding of the modes employed and the recontextualization and adaptation of texts and images, especially to the new web genres. Nowadays, the tourist experience is mediated by personal, digital, and mobile technologies, which redirect the tourist gaze and become the mediator between the traveler and the tourist destination.

Consequently, the tourism text must be considered as a single unit, where different semiotic resources intermingle to enhance its communicative strength.

The present study will attempt to propose a methodology to read and write tourism texts in a comprehensive and effective way. It will start by focusing on the relationship between text and image to see how they co-exist in the page and in the way the page is arranged. Then, it will apply a functional approach to the analysis of such semiotic units. The result will show how the boundaries between image and text have become blurred, and textuality is built less through verbal syntax and more through rhetorical visual design.


OBJECTIVE
To find out the pathological change and the toxic mechanism of Chloranthus serratus Roem. et Schalt in mice.

METHODS
Mice were intoxicated by oral administration with extracts of Chloranthus serratus Roem. et Schalt followed by pathological, serum biochemical, and coagulation mechanism examination.

RESULTS
The LD50 in mice was 41.12 g/kg; All poisoned mice serum BUN and ALT increased markedly; Thrombocyte decreased and coagulation time increased; The organ index of liver, spleen and kidneys increased significantly; The cells of liver, kidney and heart were degeneration and necrosis, There were extensive hyperemia and hemorrhage in many organs.

CONCLUSION
The experiment suggests that the target organs were liver, kidney, heart and blood vessels; The toxic mechanism was the damage on the mitochondrional, endoplasmic reticulum and coagulation system.


Many patients with intestinal Behçet's disease (BD) still suffer from gastrointestinal symptoms despite the disease being in endoscopic or radiological remission. Previous studies report that small intestinal bacterial overgrowth (SIBO) can be associated with inflammatory bowel disease. However, there have been no reports about SIBO in patients with intestinal BD. We sought to identify the frequency of SIBO in patients with inactive intestinal BD by hydrogen breath test (HBT) and to investigate the efficacy of rifaximin as a treatment for SIBO.


The two isomeric [4+2] cyclo-adducts from two different 1,3-dienes may result from direct cycloadditions as well as from Cope rearrangements (Scheme 1). This general question is tackled by employing two energetically different types of dienes, protonated pyrazolines (1H+, 2H+) or dihydropyridazines (3H+), prepared in situ from their trimers and alicyclic (4–6) or aliphatic (7–9) 1,3-dienes. Depending on structural features and conditions (amount of acid, reaction time), various ratios of the two isomeric [4+2] cycloadducts A and B are obtained; A and B are azo compounds 10, 14, 16, 20, 22, 24, 27, 32, 34, 36–39, 41, 42, pyrazolines endo-11, endo-13, endo-15, endo-endo-17, endo-18, endo-19, 21, 23, 25, 26, 28, and hydropyridazines 31, endo-33, endo-35, 40 and 43 (Schemes 3, 4). These results were backed by others from acid-catalyzed isomerizations, trapping experiments, and calculations of the equilibria (ΔΔH) between the isomers (by analogy with the corresponding olefins). A critical discussion reveals: a) Azo compounds 20, 22, 24, 27, 34, 38, and 42 must result from a [4++2] cycloaddition with inverse electron demand, whereas hydropyridazines endo-33, endo-35, 40, and 43 originate from a [4+2+] cycloaddition with normal electron demand. b) All isomerizations occur by a [3,3] sigmatropic rearrangement; [4+2] cycloreversion is energetically disfavored. c) A clear-cut distinction between the [4++2] or [4+2+] cycloaddition reaction routes to the energetically well-balanced systems 10→endo-11 and 12→endo-13 is not possible. d) The two cycloadditions may well favor a nonconcerted reaction through an allylic cationic intermediate which also governs the [3,3] rearrangements (Scheme 8).


The distribution of galaxies on scales larger than approx.10 h/sup -1/ Mpc seems to be characterized by large voids, (20--40) h/sup -1/ Mpc in diameter and of amplitude deltaapprox.-(0.7--0.8). It was previously argued that the mere existence of such voids poses a severe problem to all dissipationless clustering theories. Here we show that the voids may, in fact, be a natural outcome of a dissipationless clustering scenario if both adiabatic and isothermal density perturbations exist primordially. When the nonlinear evolution of spherical voids of this type is followed for adiabatic perturbations with an index n>-1, it is seen that they become surrounded by a shell of positive density contrast. Their structure is insensitive to ..cap omega../sub 0/ while their dynamics is quite sensitive to it. The maximum peculiar velocity (relative to Hubble flow) within the void is found to be: v/sub p//v/sub H/approx.(0.4--0.5) for ..cap omega../sub 0/ = 1.0, approx.(0.2--0.25) for ..cap omega../sub 0/ = 0.45, and < or approx. =0.09 for ..cap omega../sub 0/ = 0.1.


Social equity commonly refers to fairness or impartiality, usually in terms of inputs or outcomes related to social and economic opportunity. In the case of urban planning, social equity can take the form of participation in decision-making activities, especially those that involve allocating public resources. An assumption (and hope) is that through participation, stakeholders have greater influence on outcomes that are in their collective interest. Opportunities to participate are rapidly expanding along with rapid technological innovation. Therefore, the authors argue that there is a connection among participation, equity, and technology in creating more equitable governance structures. In particular, the authors discuss how information and communications technologies can serve to reduce barriers to information exchange and thereby generate stronger bonds and quicker formation of partnerships and connections within the public realm. This chapter explores these issues through the lens of e-government, e-democracy, and the digital divide in a U.S. context.


A novel VLSI algorithm for computing the discrete cosine transform of variable length is proposed. By using some mathematical techniques, any general length DCT can be converted into a recursive equation and this structure can be realised using software, hardware and VLSI techniques. The formulation is particularly suitable for the real-time computation of the DCT and this algorithm can be implemented using regular and parallel VLSI structures, so that the computational complexity is greatly reduced. It can also be extended to implement a two-dimensional DCT in a straightforward way.


In traditional BFSK, two distinct carrier frequencies are used to represent binary '1' and binary '0'. In this paper, we propose transmitting multiple, orthogonal, in-phase sub-carriers around two carrier frequencies to represent the binary information. We demonstrate that this technique is spectrally efficient when compared to traditional BFSK. Performance and data rate benefits are also demonstrated in both non-coherent and novel coherent reception techniques. Moreover, while traditional BFSK is not employed in channels that are frequency selective, we show that with coherent reception, the new FSK scheme can be used in frequency selective channels to exploit frequency diversity benefits.


The nitrite is a colorant and usually added to cured meat,but it is toxic to human,and the product nitrosamine has carcinogenesis.The researchers begin to search for substitute for nitrite.Comparing with synthetic pigment,the natural pigment is more prominent because of its higher safety.The addition of nitrosohaemoglobin pigment,monascus pigment and sorghum pigment will give the cured meat a good color.


cyclic change as distinguished from the short-period fluctuations which have irregular periods and amplitudes and are characteristic of every cycle. The mean Wolf number for 1928, 77.8, may be taken as a measure of the maximum activity of the cycle for comparison with other cycles. The maximum yearly averages in the four previous cycles were 103.9 in 1917, 63.5 in 1905, 84.9 in 1893, and 63.7 in 1883.


The macrobicyclic molecules (1a–c) have been synthesized; they are heteroditopic ligands combining a 'soft' and a 'hard' binding subunit, which form lateral dinuclear cryptates such as [Rh+–CO, Mn+⊂(1a–c)] by selective complexation to a given site.


Discusses the effects of the implementation of Just‐in‐Time (JIT) in the relationships between suppliers and manufacturing companies within Swedish industry. Explores whether such relationships will be beneficial for all parties and create higher total economic effectiveness in the supply relation or if the often more powerful buyer only transfers its stock holding problems to the smaller and weaker part in the buyer‐supplier relation. Two buyer‐supplier relations in the automobile industry are studied, one more from the buyer′s point of view and the other from the supplier′s side. Proves that there are very clear possibilities to get higher total effectiveness in such relations and that mutual benefits are really obtainable. Shows the increased importance of reduced arrival variancy but also that JIT does not necessarily mean an increased traffic intensity. Introduces an important finding by identifying the time interval between the Sequence Locking Instant and the point when the component is needed in P...


Objective To establish a stable mouse embryonic fibroblasts(MEF)as feeder layer in order to culture mouse embryonic stem cells(ESC)in vitro.Methods Primary mouse embryonic fibroblasts(PMEF)were isolated from 10.5~18.5-day-old fetus mouse.The condition of cells in proliferation,subculture,freezing and anabiosis were investigate and the MEF cell line bought from ATCC as feeder layer to support the growth of ESC.Results (1)The optimal gestational age for isolation of MEF was bought from 12.5 to 14.5 day.(2)At the temperature of 37 ℃ and using the combination digestive juice of 0.25%trypsin-0.02%EDTA,The optimal time for isolation of MEF was 3~5 min.(3)The average time for the passage of PMEF was 4 days.The optimal concentration of mytomycin c to inhibit proliferation of fibroblasts was 10~20μg/ml.(4)The better cell to establish feeder layer was PMEF.Conclusion These two kinds of cells were available to establish feeder layers.


Methods and compositions for plating a metal contacts on the solar cell is described. Batteries, and metal ions capable plating, are dipped in a water-containing bath containing a solubilizing agent of aluminum or aluminum alloy ions from the back side of the solar cell. Cell is then exposed to light, it produces oppositely charged on both sides of the battery. Metal ions are plated without the need for external electrical connection.


Tube forming can be used for producing parts with high efficiency,low consumption,and high precision and therefore becomes one of the most important processes of advanced plastic forming It is important to study and master several principle for the development and application of advanced tube processing technology In this paper,research progress on some important problems needed to be resolved urgently are reported in tube axial compressing precision forming and thin\|walled tube bending field


The Japanese health and welfare ministry is drawing up new rules to deal with medical malpractice in response to a rising number of accidents at hospitals. In the first plan of its type, the ministry will spell out procedures for reporting unexpected deaths or injuries among patients receiving …


Small heat shock proteins(sHsp),representing an important molecular chaperone in eukaryotic cells,play important roles not only in a variety of stress responses,but also in development and signal transduction of normal cell.In this study,based on unigene sequences which were obtained from whole transcriptome sequencing of Pyropia haitanensis,two full-length s HSP genes were obtained by rapid amplification of cDNA ends(RACE) or direct PCR,which named Ph Hsp22 and PhDnaJ.The full-length cDNA of the Ph Hsp22 gene comprised 857 nucleotides and contained an open reading frame of 519 bp(Gen Bank accession:KM102540),encoding a protein of 172 amino acid residues with the predicted molecular weight of 19.1 ku and theoretical isoelectric point of 5.24;the full-length cDNA of the PhDnaJ gene comprised 1 616 nucleotides and contained an open reading frame of 1 290 bp(Gen Bank accession:KM102541),encoding a protein of 429 amino acid residues with the predicted molecular weight of 46.1 ku and theoretical isoelectric point of 6.43.On the basis of conserved motifs and phylogenetic tree analysis,PhDnaJ belongs to the subfamily of Hsp40.The expressions of the two genes,as measured by real-time quantitative PCR,were significantly induced by high-temperature stress and desiccation stress,and had identical expression patterns:during high-temperature and desiccation stress,the expression levels of the two genes all significantly increased firstly and then decreased.These results suggested that the expressions of Ph Hsp22 and PhDnaJ genes are feedback regulated by high-temperature and desiccation stresses.


In this paper, we investigate the gravitational effects of a global monopole that couples nonminimally to gravity. Considering a coupling parameter of arbitrary strength, we have obtained an analytical solution for the field equations of the model in the asymptotic region outside the monopole's core, thus generalizing previous results. Within the weak coupling regime, we have also analyzed how this matter-geometry interplay affects some physical properties of the monopole, such as its radius and the mass enclosed in its core, which are explicitly computed and expressed in terms of the parameter of the theory. Using the Hahari-Loust\'o toy model, we have also found that the modification of general relativity (GR) may render a positive sign to the monopole mass, which means a global monopole able to exert attractive gravitational force on matter particles surrounding it. Next, we have studied some properties of a hairy black hole carrying such a global monopole charge. In this vein, we verified that the deviation from GR may provide such a spacetime with both event and Cauchy horizons, thus emulating a Reissner-Nordstr\"om framework. Finally, we have performed a study of the geodesic motion of timelike particles around this black hole by setting the conditions for stable circular orbits. We also examined the gravitational bending experienced by photons traveling through this geometry, taking into account finite-distance corrections on the deflection angle. Additionally, we make an order-of-magnitude estimate for this extra contribution considering the light bending caused by Sagittarius A*.


Photonic-crystal structure was fabricated in GaN-based light-emitting diode and the recombination lifetime was estimated by time-resolved photoluminescence measurement. It is demonstrated that Purcell effect can reduce the recombination lifetime and enhance the carrier- limited modulation bandwidth.


With the popularity of clean energy utilization and the in-depth development of microgrids, virtual synchronous power generation technology has received more and more attention. Control strategy techniques based on the simulation of synchronous generators can provide effective frequency and voltage regulations for renewable energy electrical systems. However, the synchronous generator is similar to a voltage source, and simply simulating the synchronous generator's equations will make the converter exhibit uncontrolled characteristics on the short-time scale for electromagnetic transients. Due to the flexible control property of the converter, the current control can be further increased to achieve electromagnetic transient control based on the slow time-scale feature of the virtual synchronous generator. This paper proposes an electromagnetic transient control method for virtual synchronous generation technology. The method can effectively control the short-time scale electromagnetic transients and preserve the slow dynamics and has the advantages of parameter robustness and structural simplicity.


A central hollow core, inflatable and outer balloon, and at least one internal balloon inside the outer balloon, a medical device for extending constriction of the patient's airway. The apparatus can also include a strut member shrinkage which is mounted on the outer surface of the outer balloon by at least one microsurgical blades. Outer balloon can when balloon is inflated, a dumbbell to store balloon in position for stenosis. Hollow core allows the patient is subjected to artificial respiration during treatment, the internal balloons allows the higher expansion pressure is generated from an internal outer balloon, the blades on the expansion of the outer balloon it is possible to form an effective forefront.


This research was conducted to analyze the urgency of history learning media innovation. The development of the times puts history learning to have challenges to be able to adapt the learning targets faced, namely the Z Generation. This generation was born in the early 2000s. The character of this generation is very sensitive to technology and communication, meaning that they have advantages in the field of information and knowledge. Meanwhile, educators who were born in the previous era are still didn't used to it, so that educators often admit to being "gaptek" (stuttering technology). Therefore, this study describes the urgency of developing Mobile Learning media using local historical sites. The description presented covers the development stage of the first part. This section describes a preliminary study to see potential problems and analyze the needs of students in learning history. The results obtained from this study are quite significant with the percentage reaching above 80% for the category of interest in mobile learning media. In the early stages of product development, the materials and media produced from the field research process at the historical site of General Sudirman in Pacitan is also presented. In addition, it also describes the form of the media design as an initial draft with adjustments to the learning interests of the Z Generation. So, Mobile Learning is expected to facilitate the Z Generation in learning history.


The tetrad representation theorem, due to Spirtes, Glymour, and Scheines (1993), gives a graphical condition necessary and sufficient for the vanishing of an individual tetrad difference in a recur...


The problem that this study focused on was that there was minimal evidence on whether or not nursing students become more assertive throughout their academic education. The purpose of this study was to compare the assertiveness scores of sophomore level nursing students and senior level-nursing students. The study was guided by Hildegard Peplau's theory of interpersonal relations in nursing, which described focuses on the therapeutic process between nurses and patients, rather than on internal patient pathology. The descriptive, comparative study used a 15-question survey design and a convenience sample of sophomore and senior level nursing students at a large urban Midwest university. Recruitment, informed consent, and data collection occurred during the sophomore and senior classes. A two-sample T test was used to determine group differences in assertiveness. The results revealed that the sophomore level students were more assertive than the senior level-nursing students.


The paper is mainly devoted to the irreducibility of the polynomial representation of the double affine Hecke algebra for an arbitrary reduced root systems and generic "central charge" q. The technique of intertwiners in the non-semisimple variant is the main tool. We introduce Macdonald's non-semisimple polynomials and use them to analyze the reducibility of the polynomial representation in terms of the affine exponents, counterparts of the classical Coxeter exponents. The focus is on the principal aspects of the technique of intertwiners, including related problems in the theory of reduced decompositions on affine Weyl groups.


Integrated energy system (IES) is essential to achieving carbon neutrality and carbon peaking. However, the IES has a complex structure and multi-agent characteristics, so it must rely on reasonable market mechanisms to realize the large-scale application. This paper proposed the multi-agent market mechanism of the IES based on game theory. Firstly, the mathematical model of the system considering carbon trading is developed. Next, the market mechanism between the supply and demand sides is designed under the framework of the Stackelberg game and then solved by a self-designed hierarchical algorithm. The results show that the proposed method achieves the low carbon and economic operation of the IES.


Thermal management is a major design challenge in three-dimensional dynamically partially reconfigurable systems. Unlike three-dimensional integrated circuits, thermal management is more difficult in three-dimensional dynamically partially reconfigurable systems because of the extra heat generated by task reconfiguration. This study proposes an on-line thermal-aware task management scheme to reclaim the run-time thermal slack from low-power tasks, and uses a configurable thermal threshold to achieve a trade-off between the reconfiguration overhead and thermal distribution. The proposed scheme maximizes the tolerable task execution power to better utilize the system and provides a quality of service guarantee under the thermal constraint. This study also evaluates the capability of the proposed methodology using a series of experiments, presenting encouraging results.


synchrotron light imaging monitors available in VEPP-2000canbeusedforevaluationofdynamicbetasand emittances at collision. Tomographic techniques are useful for reconstruction of non-gaussian beam phase space at the IPs at high intensities of colliding bunches. The output is applied for prompt luminosity monitoring.


We report the preparation of a new type of nanocomposite containing cobalt and silver nanoparticles organized in parallel layers with a well controlled separation. This arrangement allows the observation of an enhanced low-frequency Raman signal at the vibration frequency of cobalt nanoparticles excited through the surface plasmons of silver nanoparticles. Numerical simulations of the electric field confirm the emergence of hot spots when the separation between silver and cobalt nanoparticles is small enough.


This report describes the project of investigating the English-language newspapers and periodicals published in China before 1949, a unique set of historical materials that are often overlooked in both scholarship and librarianship.


We examine culture- and racial-based toxicity and hate speech in player communities and explore how this toxicity might be informed and affected by the design of the game elements and content. To illustrate these effects, we used a mixed method approach to analyze the experiences of players from the Middle East and North Africa (MENA) regions within the League of Legends (LoL) community as a case study. By qualitatively and quantitatively analyzing more than 2 million lines of in-game chats from 30,000 game sessions on 2 LoL servers and also 89 forum discussions containing hundreds of lines of text, we find that despite the world and characters of LoL being fictional, they are recognized by the player base as having connections to the real-world cultures and, accordingly, they affect the way that players communicate. We provide specific examples of both negative and positive inspirations to elaborate on how the design of certain regions and characters affects the way that the MENA players and issues are received or addressed. Additional analysis of in-game chat data describes other topics where toxic behavior emerges and how these topics correlate.


Context: Virginia has the nation's highest rate of obese children two to four years old enrolled in the federally supported Women, Infants and Children Nutrition program. Southwest Virginia consistently has higher rates of childhood obesity compared to the rest of the state. The researchers proposed that a discordance exists between caregivers'/parents' knowledge, attitudes and behaviors related to childhood nutrition. Objective: To identify challenges facing parents of children contributing to the high obesity rate in the region. Methods: This study used a cross-sectional study design and an anonymous 33 item survey administered to parents of children six years of age or younger in the waiting room of a pediatric clinic. Results: Responses from parents (n=28) indicated that the majority were the parent, white, well educated, and most worked outside the home with incomes above $50,000. Parents (86%) disagreed with the statement, "A fat child is a healthy child". Parents' responses regarding diet quantity were less consistent; 60% agreed with both statements, "I let my child decide how much to eat," and, "I am very careful not to feed my child too much". Participants' were conflicted regarding food quality, with 39% agreeing to, "A child should never eat fast food," while others were neutral (32%) or disagreed (29%). Most parents (68%) agreed with the statement, "I let my child eat fast food." Logistic regression confirmed relationships, e.g., parents that disagreed with, "I let my child eat sugary foods like candy, ice cream, cakes or cookies", were less likely (99% lower odds) to report agreeing with the statement, "I let my child eat junk food like potato chips, Doritos and cheese puffs," and less likely (97% lower odds) to agree with, "I let my child eat fast food" (p <0.001). Conclusion: Parent knowledge, attitudes and behaviors indicated a need for nutrition education appropriate for the parent's style and child's development as a way to improve the nutritional status of children in southwest Virginia. Additional studies are recommended to 1. increase respondent numbers and demographic diversity 2. assess children's nutritional status and 3. evaluate benefits of educational sessions or parents/caregivers.


Dental and allied dental education leaders from around the world shared insights and information at the American Dental Education Association's Third International Women's Leadership Conference in Montreal, Canada, August 28–30, 2005. The conference theme, "Global Health Through Women's


A new isopentenyl diphosphate isomerase gene cwipi (GenBank: GU724874) was cloned from the Curcuma Wenyujin cDNA library. The full-length cDNA contained a 708 bp open reading frame (ORF) encoding a protein of 235 amino acids with calculated molecular mass of 27.36 kDa and isoelectric point of 5.14. Phylogenetic analysis demonstrated that cwipi has a high level similarity to other IPIs belonged to angiosperm group. The protein encoded by cwipi was subcellularly localized to the cytoplasm using TargetP prediction software. Semi-quantity RT-PCR results indicated that the transcriptional level of cwipi in roots was higher than that of in stems and leaves. Cwipi could accelerate the accumulation of β-carotene when it was expressed in Escherichia coli harbouring reconstructed carotenoid synthetic pathway. The cloning, characterization and functional analysis of cwipi will be useful for understanding the role of IPI in isoprenoid biosynthesis of C. Wenyujin.


This paper proposes a numerical method with an inverse boundary element method (IBEM) to design a set of shim coils for an open bipanar superconducting magnetic resonance imaging (MRI) system. For the traditional cylindrical MRI system, claustrophobics will suffer the palpitations and anxiety attacks when they are enclosed in a small area during the scanning process. However, such bipanar structure provides an open room temperature bore, thus improving patients' comfort. Based on the IBEM, the shim coil skeleton needs to be divided into some small flat triangular elements. By formulating the magnetization distribution by discrete current density, an objective function is constructed to evaluate the minimum error between axial magnetic field and desired magnetic field. In particular, the selfinduction is added into the objective function which is used to adjust the deviation from the ideal target field. Finally, the well-known stream function method is commonly used to map the current density into wires. The algorithm details have been exemplified through biplanar shim coil design examples in this paper. This method can be used for coils on arbitrary surface shapes.


: Badminton is one of the university physical education courses recently opened in our country. Badminton has good fitness effects and strong entertainment, and is very popular among college students. However, in the short-term development, a relatively complete and effective teaching method has not been established. Competitive analysis is needed to fully improve the quality of badminton training. In this paper, the competition teaching method and the TextRank algorithm are used to study the practical effect of the competition teaching method in the badminton optional course. Based on the background of big data, this paper uses the TextRank algorithm to study the application research and practice of the competition method in badminton teaching, and establishes a potential mathematical model. The model is solved by the game teaching method and the TextRank algorithm, and the application research and practice of the competition method in badminton teaching are evaluated, and the model is revised using historical data to improve the accuracy of the application research and practice evaluation of the competition method in badminton teaching Sex. The experimental results of this paper show that the TextRank algorithm improves the application research and practical research efficiency of the competition method in badminton teaching by 13%, and reduces the rate of false positives and false positives. Finally, through the analysis of the role of the comparative competition method in badminton teaching and the analysis of the short-term teaching effect of the badminton group competition teaching method, the influence of the application research and practice of the competition method in badminton teaching is systematically explained.