Objective To observe the response rate and toxicity of taxotere plus cisplatin combination in the treatment of advanced non-small cell lung cancer(NSCLC).Methods A total of 72 cases was included in the study.Taxotere was given 75mg/m2 introvenously on d1,and cisplatin 25mg/m2 introvenously on d1~3 of each cycle,21 days for each cycle.Each patient should complete two cycles.Results An objective response rate was obtained in 43.05% of 72 patients.The response rate was 45.45% in the initial patients,and 41.03% in the retreated patients.No significant difference existed between the two groups(P0.05).The main toxicity was hematological:Grade Ⅲ~Ⅳ leukopoenia was 29.16%,GradeⅢ thrombocytopenia was 5.56%.The non-hematological toxicity was mild.Conclusion Taxotere plus cisplatin is effective and well-tolerated in the first-line or second-line treatment of advanced NSCLC.


In mass%, C: 0.06 ~ 0.12%, Si: 0.5 ~ 1.5%, Mn: 1.0 ~ 3.0%, P: 0.05% or less, S: 0.01% or less, Al: 0.5% or less, N: 0.01% or less and Ti : containing 0.02 ~ 0.20%, and the following formula (1), (2) satisfy the relationship shown in formula, a composition comprising the balance Fe and unavoidable impurities and, as the area ratio of ferrite phase: 60% or more, maten Xi-form: 15 to 35%, and the addition of the ferrite phase and maten ZUID sum is 95% or more, average particle diameter of the ferrite is 4.0 ㎛ or less, the average particle diameter of maten ZUID is 1.5 ㎛ or less, rolled right angle on tensile strength ㎫ than 780, Young's modulus of more than 240 ㎬, strength-elongation balance 16500 ㎫ ·% or more steel sheet. 0.05 ≤ [% C] - ( 12 / 47.9) × [% Ti *] ≤ 0.10 --- (1)


If the deuteron were an elementary particle then the triplet n−p effective range would be approximately −ZR(I−Z), where R=4.31 F is the usual deuteron radius and Z is the probability of finding the deuteron in a bare elementary-particle state. This formula is model-independent, but has an error of the order of the range mπ−1=1.41 F of the n−p force, so it becomes exact only in the limit of small deuteron binding energy, i.e., R≫mπ−1. The experimental value of the effective range is not of order R and negative, but rather of order mπ−1 and positive, so Z is small or zero and the deuteron is mostly or wholly composite.


The pollination of the DK 440 BTY (MON 810 genetic event) maize variety falls between the 74 and 88 day after sowing. The pollination of Hungarian maize varieties takes place during the course of July and August. In the case of the variety surveyed in our research – generating some 35 kg/hectares of pollen – the pollen coverage drops to 100 pollen grains / cm at a distance of 5 metres from the edge of the maize field. Caterpillars that hatch during the pollination period and feed on herbs in and near the maize field are most heavily affected by the toxin content of the pollen. The leaf surface/leaf mass ratio of stinging nettle (Urtica Dioica L., Urticaceae) is 2.85 times greater than that of common milkweed (Asclepias syriaca L. Asclepiadaceae). In the case of equal pollen coverage, this means an approximately three times higher Bt-toxin dose. There are 187 protected butterfly species in Hungary, 16% of which may develop on herbaceous weeds along maize fields as well. In the nettle growths in the drainage ditches of maize fields, the hatching of the larvae of two common butterfly species of the Nymphalidae family – peacock, Inachis io (L.) and red admiral (Vanessa atalanta) (L.) – coincides with pollination, as a consequence of which they are exposed to the Bt-contents of the maize pollen.


Introduction Double-gated devices are expected to push transistor gate length scaling down to as low as 10 nm [1]. This technology may allow transistor scaling to continue for the next 15 years or more. High potential for the double-gate FinFET has been demonstrated through the creation compact SRAM cells [2]. Compact IC fabrication is critical where transistor size limits density and cost. This concern is especially true in memories. A general rule of thumb in double-gated devices is that LG/TSi should be greater than 2 to alleviate short-channel effects. Qualitatively, shortchannel effects originate from punch-thru in the center of the silicon body in double-gated devices. By reducing the body-thickness, the region where punch-thru can occur is reduced. The rule-of-thumb given above makes sense in light of a derivation from 2-d fields with the assumption that change in field in the y-direction is zero in the center of the silicon body as outlined in Suzuki's paper, [3] which states that lambda, λ, the natural length corresponding with punch-thru immunity, is given as λ = sqrt({ (εSi/(2εox)) [1+ (εSi/(4 εOx)) (TSi/Tox)] (TSiTox) }).


In an aqueous solution, nicotine, and tryptophan alone, and phenylalanine and / or tyrosine, and / or having a combination of active ingredients, including caffeine, pharmaceutical formulations and methods of use thereof for use in migraine therapy. .BACKGROUND


Techniques are developed for use in estimating 100-year flood depths on New Jersey streams. Equations and graphs are presented relating the 100-year flood depth above the mean annual flood to drainage area and area of lakes and swamps. Separate relations for the coastal plain and noncoastal plain streams in the four hydrologic areas in New Jersey are shown. A method of mapping flood-prone areas on U.S. Geological Survey 7-1/2 minute topographic quadrangles is detailed in this report. INTRODUCTION Maps outlining areas of potential flood hazards are a useful tool in flood-plain management. Preparations of these maps usually require estimating the flood depth for a particular recurrence interval. The 100-year flood depth, an event having a probability of about 1 in 100 of being equaled or exceeded in any year, is generally used in their preparation. The purpose of this study is to extend the flood-depth estimating procedures presented in Thomas (1964b) to include the 100-year flood and to simplify application of the procedure. Presented in this report are methods that can be used to quickly identify flood-prone areas. Planners, engineers, builders, and others interested in determining flood depths will find the techniques outlined in this report useful. The depth of the 100-year flood above the mean annual flood can easily be estimated for a site on a stream using the graphs, equations, and maps in this report, along with topographic maps. The method outlined is especially useful where approximate results are required quickly and economically. The method presented in this report was used by the New Jersey District of the U.S. Geological Survey to delineate flood-prone areas on 7-1/2 minute U.S. Geological Survey topographic quadrangle maps (scale 1:24,000) where historic profile data were not available. METHOD OF ANALYSIS The relation of flood depth to flood discharge, pveloped by Leopold and Maddock (1953), is of the form d = cQ , where d is the average cross section depth, Q is the discharge of a given frequency, and c and f are constants for a given frequency. Using this equation, Thomas (1964b) developed a method for predicting flood depths for various frequencies in New Jersey. He presented graphs showing the relation between mean annual flood discharge (Q2 3and flood depth for recurrence intervals of 1.5 to 5d years; where depth is measured above the average stream bottom. Thomas (1964a), in an earlier report, presented graphs showing the relation of mean annual flood discharge to drainage area and area of lakes and swamps. The relation of flood depth to discharge was extrapolated in this study to include the 100-year flood. Flood depth was then related directly to drainage area and area of lakes and swamps in percentage of drainage area. Thomas (1964b) defined flood depth to be the height above average stream bottom. In this study, the 100-year flood depth is the difference between the depth of the 100-year flood and the mean annual flood.


The Solar Isotope Spectrometer (SIS) aboard the Advanced Composition Explorer (ACE) has been
measuring solar energetic particle abundances since ACE was launched in August 1997. SIS is a silicon
detector telescope that identifies charged particles via the multiple dE/dx vs. total energy technique, and to
date, most measurements reported by SIS have been limited in energy to those particles that stop in the
instrument. In this paper, we will summarize the multiple dE/dx technique used to identify particles that
penetrate through the bottom of SIS, extending the energy ranges for elemental abundance measurements.
In preliminary analysis, the upper energy limit for oxygen has been extended from ~90 MeV/nuc for
stopping particles to ~300 MeV/nuc for penetrating particles, and the upper energy limit for iron has been
extended from ~168 MeV/nuc to ~500 MeV/nuc. We apply this technique to SIS measurements of large SEP
events, such as the Nov. 6, 1997 event and the recent Jan. 20, 2005 event, to extend the measured spectra, to
look for evidence of spectral breaks.


Background: Gene polymorphisms have been associated with drug-induced liver injury (DILI). This study aimed to elucidate the association between polymorphisms of NAT2, CYP2E1, GSTT1, GSTM1, and HLA genes with isoniazid plasma concentration and DILI. Methods: This study was a prospective cohort study recruiting adult newly diagnosed tuberculosis (TB) patients who met the inclusion criteria from the Public Health Centers in Yogyakarta and Lampung. Defined single-nucleotide polymorphisms were rs1799929, rs1799930, rs1799931, rs1801280, and rs1041983 of NAT2; rs2031920, rs8192775, and rs2515641 of CYP2E1; rs1041981, rs1063355, and rs6906021 of HLA. GSTT1 and GSTM1 were defined as GSTT1, GSTM1, and GSTT1 deletion and GSTM1 deletion. The DNA was taken from the patient saliva. Data of anti-TB drug plasma concentration on the weeks 4–8 of treatment were retrieved from the patients' medical report. Statistical analysis was performed using Chi-square test, Student's t-test, and multinomial logistic regression. Results: Over the 207 patients, up to 1.9% of them experienced DILI. The percentage of slow acetylators of NAT2 was 69.5%. Patients with extensive acetylator phenotype did not experience DILI (odds ratio [OR]: 0.46; 95% confidence interval [CI]: 0.23–0.94). The G carriership of HLA rs1063355 could protect the patients from the DILI (OR: 0.39; 95% CI: 0.14–0.9). Furthermore, the C carriership of HLA rs1041981 can protect the patients from DILI (OR: 0.38; 95% CI: 0.15–0.50). The genotype of HLA-DQB*0302 significantly affects the isoniazid concentration. Conclusion: The NAT2 genotype was significantly associated with DILI. Furthermore, the absence of G carriership of HLA-DQA*0102 could protect the patients from DILI without being associated with an effect on the isoniazid concentration.


I was born at Papunya. My mother is Warlpiri and my father is Pintupi. I speak Warlpiri, my mother's language, and Pintupi, my father's language. My mother's name is Peggy Nagala Ross. My father's name is Banjo Jungarryi Tex. My father was born at Nginyinipalangu (Lake Mackay) area, and when he was a middle-aged man he went to Mount Doreen station. My mother was married to Charlie Jungarryi Jurrah, first.


This paper examines the impact of entry strategy on new venture performance. The contradictory nature of a simplistic view on the relationship between timing of entry and new venture performance is demonstrated. Contingent relationships between timing of entry and other entry strategy variables lead to a series of propositions.


This paper analyses the impact of welfare systems and longevity on savings. It develops a life-cycle model embodying social transfers (health care and pension expenditures) and changes in longevity to determine the level of household savings. We simulated an aggregate saving equation and derived a reduced-form model, together with other factors such as public deficits and the population structure. The model is estimated for a panel of 18 OECD countries. Our principal result is that both pension and health transfers may have a significant negative impact on the household saving. Therefore these interactions should be taken account when designing welfare reforms.


The spatial variation of arbuscular mycorrhizal fungal spores under the canopy of Acacia raddiana was studied in a desert system. Soils samples from the base of the stem, its canopy radius, and outside its canopy at four stations in the Negev desert were collected from a 0 to 50 cm depth at sections of 10 cm each. The mean spore density was found to fluctuate between 265 100 g−1 to 105 100 g−1 in fluvisols and calcaric fluvisols, respectively. Our results suggest that spore density and spore distribution were found to be directly correlated with soil type, elucidating the importance of soil physical composition on AM fungi distribution in desert soil ecosystems.


Objective: To compare the effects of the natural and the surgical menopause (SM) on climacteric condition. Materials and methods: This prospective study was conducted from Jan 2008 to Jan 2013 in ZHSWMCH. Initially, 4,000 women were enrolled but finally 1,743 of natural menopause (NM) and 554 of SM were analyzed. All women were aged between 45 and 50 years, and they were of menopause for 1 to 5 years. Ethical and patient's permission was taken. Once enrolled, they were asked questions. The questions were related to menopausal symptoms (MS). Data was collected and analyzed by SPSS software. Results: Hot flushes, (535 vs 290, p < 0.001), sweating (344 vs 122, p < 0.001), poor memory (99 vs 65 p < 0.001), feeling depressed (335 vs 126, p < 0.001), dry skin/mucosa (229 vs 91, p < 0.001), decreased libido (289 vs 117, p < 0.001), dry vagina (99 vs 65, p < 0.001) and urinary complains (59 vs 42, p < 0.001) were found in SM vs NM. Hypertension or cardiovascular disease was more (191 vs 92, p < 0.01), blood sugar were more (90 vs 32, p < 0.001) and metabolic syndrome are also more (48 vs 26, p < 0.07) in SM than NM but this did not reach the significance. Conclusion: Menopausal symptoms are common in both NM and SM. These MS were significantly higher in surgically menopause women and they were troubled more, so we need to be cautious about oophorectomy, and ovarian preservation should be the aim in all benign cases. Of course, we need to assess the risks and benefit where there is risk of ovarian cancer during the time of total abdominal hysterectomy. Both hormone replacement therapy (HRT) (following a risk/benefit analysis) and treatment of osteoporosis may be recommended after surgery to decrease the climacteric symptoms and osteoporosis in women with menopausal symptoms.


After myocardial infarction (MI), paracrine signalling has been shown to contribute to heart regeneration. The epicardium, as an important signalling centre, is crucial for heart development and it is re-activated after MI, indicating its involvement in the response to injury. This project aims to accomplish
 in situ
 transfection of the epicardium to stimulate the overexpression of growth factors that will enhance regenerative signalling pathways after MI, with cardiomyocyte proliferation as the primary target. Selective epicardial transfection can potentially be achieved via a surface-mediated delivery. Therefore, we developed a novel transfection approach consisting of the deposition of bioreducible cationic polymeric polyplexes onto flat and nanostructured silicon surfaces by freeze-drying. Recombinant growth factors (rGF) were used in single and combinatorial proliferation assays to select for genes to be delivered to the epicardium. The proliferative effects were assessed on cardiomyocytes, cardiac mesenchymal stromal cells, endothelial cells and cardiac fibroblasts via high-content image analysis. Neuregulin-1 led consistently to higher S-phase proliferation marker in IMR90- and H7-derived cardiomyocytes and higher cardiomyocyte cell numbers (fold increase 1.28 ± 0.12), quantified by flow cytometry. Hepatocyte Growth Factor induced proliferation of cardiac mesenchymal stromal cells (fold increase 2.75 ± 0.31) and angiogenesis (fold increase 1.47 ± 0.34). Follistatin-like 1, from animal and bacterial sources, was also tested but no proliferative effect was detected. The relevant rGF for each cell type maintained its positive effect in combination with other rGFs. Furthermore, preliminary results from
 in vitro
 transfection of epicardial cells with these GF genes indicate the proliferative advantage of enriched epicardial paracrine signalling over the incubation of cardiac cells with the rGF
 .
 This study remains to be a first-in-field potential material-based gene delivery strategy specific to the epicardium that explores a combinatorial treatment via the delivery of more than one gene for induction of cardiomyocyte proliferation and other regenerative mechanisms for MI treatment.


Background: Head and neck lesions encompass a multitude of congenital, inflammatory or neoplastic lesions including several anatomic sites and originating in different tissues and organs. Fine needle aspiration cytology (FNAC) is a simple, quick, feasible, cost effective and repeatable outpatient procedure with minimal risk of complication.
Aim:
1. To evaluate the role of FNAC and its utility in diagnosis of palpable head neck masses.
2. To study the spectrum of head neck lesions in rural population.
3. To study diagnostic accuracy of FNAC by histopathological correlation wherever possible.
Material and methods: The study included 288 patients presented with palpable head and neck swelling in a tertiary care hospital from January 2011 to December 2014. Detailed clinical history of patient was noted. Aspirations were done by using 10 ml syringe and 22/23 gauge needles. Smears were stained with PAP, Haematoxylin and eosin and Leishman stain. Cytomorphological diagnosis was given. Cyto-histopathological correlations were done wherever possible.
Results: Out of 288 patients of head and neck lesions studied, lymph node (39.58%) was the predominant site aspirated with tubercular lymphadenitis being the commonest lesion. Thyroid lesions constituted 31.25 % followed by salivary gland (18.75%), soft tissue and miscellaneous (7.29%). FNAC was inconclusive in 3.12 % cases. Overall accuracy rate of FNAC was 93.02% with sensitivity of 81.81 % and specificity of 96.87 %.
Conclusion: Though excisional biopsy is the gold standard for diagnosis of head and neck neoplastic lesion. FNAC is a rapid, cheap diagnostic tool now-a-days with overall accuracy rate more than 90 %.
Key words: head and neck, FNAC, rapid, diagnostic


A preliminary report is presented on the effect of correlation in the 3d/sup n/ core on the 3d/sup 10/ /sup 1/S ..-->.. 3d/sup 9/ 4p /sup 1/P f value by use of the multiconfiguration (MC) Hartree-Fock procedure. A common orbital basis was used for correlation in the core, with virtual orbitals determined variationally for the initial state. Three different approximations were used: a single-configuration approximation for both initial and final state, a MC approximation for 3d/sup 10/ correlation in the initial state and a single configuration for the final state, and MC approximations for both initial and final states. Some preliminary f values for the 3d/sup 10/ /sup 1/S ..-->.. 3d/sup 9/ 4p /sup 1/P transition are tabulated. Comparison of calculated with experimental values indicates that correlation in the 3d/sup 9/ core of the final state is needed to obtain the correct transition energy to bring the length and velocity forms into good agreement with themselves and experiment, and that the multiplet strength for the transition is not greatly affected by correlation. 1 table. (RWR)


The C4 fraction hydrogenating process includes the following steps: mixing C4 fraction material and hydrogen and contacting the mixture with hydrogenating catalyst I in a hydrogenation reactor for diolefin hydrogenating saturation reaction, contacting the reaction resultant with hydrogenating catalyst II directly without separation for impurity eliminating and olefin hydrogenating saturation reaction, and cooling and separating the reaction effluent to obtain the C4 fraction hydrogenating product. The process has mild reaction condition and can eliminate most of olefin from C4 fraction material, and the C4 fraction hydrogenating product with olefin content lower than 1.0 vol% may be used as high quality ethylene producing material and vehicular liquefied gas.


The first 10 years of Czech Republic's inflation targeting regime have been remarkable by the persistent undershooting of the inflation targets. This article is an introduction to a special issue aimed at analyzing the factors of the undershooting. The articles in this issue explore the following hypotheses: the impact of a series of counter-inflationary shocks; a biased forecasting system; a faulty decision-making system; and the role of inflation expectations. Based on a meta-analysis of the articles, this introduction suggests that the undershooting cannot be explained by a single factor, although counter-inflationary shocks are identified most frequently. The impact of the undershooting on central bank credibility was modest, partly because the forecasts were accompanied by explicit discussions of the forecast risks.


It is no.; my intention to present a lengthy paper on the aspect of grassland rarming which I have chosen, What I propose to do is merely to introduce the subject, then ask that it be fully discussed so that a definite policy may be arrived at for the guidance of farmers, agricultural instructors md seedsmen? vfho, from different standppints are all deeply interested. history (W t I should like to trace as briefly as possible the ~>i ish) of grassland farming.


We report the first demonstration of selective area crystallization of amorphous silicon films using low‐temperature rapid thermal annealing. Crystallization temperatures as low as 500 °C were achieved with the help of a thermally evaporated ultrathin metal layer. The selective area crystallization was accomplished by using this ultrathin metal layer to define the region to be crystallized. The edge between two regions, that which has been crystallized and that which has not, is found to be very sharp.


For validating rationality of heat injection in mining coal-bed gas,the experiment of desorption and seepage in non isothermal condition is done in laboratory.The results of experiment shows that the coal-bed gas increases under the condition of adding temperature and it's rational to heat injection in mining coal-bed gas.According to the experimental conclusions,the mathematic model of transferring heat process of coal-bed is given.ANSYS software is used to simulate the temperature field of coal-bed under the condition of horizontal well.The result of numerical simulation shows that the temperature gradient of coal-bed is changed after heat injection,and a displacement of thermal diffusion exists in radial direction of well.The produce of coal-bed gas increases and the desorption phenomenon is easier in the range of heat diffusion.


-This study aims to analyze the effectiveness of the science model of volcanic dust disaster approach to LiTMas (environment, technology, and society) developed for the mitigation of volcanic dust disasters before they are used in large scale trials. The package to support the development of the disaster science lecture model include the guide book model, semester learning plan, lecture program unit, reference books, lecture media, practical guides, disaster simulation guides, lecture products, and evaluation instruments. The method used in this research is the research and development (R&D) method. Subjects in the study were students of the Physics Education Study Program Faculty of Teacher Training and Education. This research produces a model of disaster science lectures by LiTMas approach that is valid, practical, and effective for mitigate volcanic ash disasters as a result of volcanic eruption activities.


The study focusses on the variation of air quality assessed from mass concentrations of air pollutants in the year 2020 (particulate matter (PM2.5 and PM10), sulphur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO) and ozone (O3)) amidst COVID–19 restrictions on firework activity during Diwali festive period in Visakhapatnam city. The results are compared with 2018 and 2019. The results indicate that the firework activity affected ambient air quality. The effect is lower in 2020 than in 2018 and even in 2019. In 2019, the effect is lower compared to 2018 due to the washout of pollutants caused by unusual rains on those days.


AbstractA highway construction cost index (HCCI) is an indicator of the purchasing power of a highway agency. Thus, it must reflect the actual construction market conditions. However, current metho...


To overcome the shortcomings of traditional automotive anti-collision system function and expand the target tracking and identification functions,this paper designed a multi-function car anti-collision system by using target detection search theory of tracking while searching radar.It expounded the design goal,function distribution and system design diagram,established the model,and simulated and analyzed the target detection curve.The predicted curve was consistent with practical curve,and threshold was adjusted by residual error curve in real-time.Simulation results show that the system can realize the predicted goal accurately.


At the ends of the distribution network, the long power supply distance and weak grid structure often lead to the power supply problems, especially when seasonal and periodic load fluctuations occur. For these intermittent loads, the peak-to-valley power difference can achieve up to nearly ten times. This difference could lead to power quality problems such as custom-side voltage sag and three-phase voltage imbalance. In this paper, a hybrid energy storage system (HESS) including both power-density and energy-density storage components is used to suppress the power fluctuation of the intermittent load. The intermittent load was modelled by analyzing its frequency characteristics with an algorithm combining empirical mode decomposition (EMD) and Hilbert spectrum analysis. Thus, the high and low frequency components of the intermittent load are determined. Then, according to the proposed power allocation strategy, the rated capacity of the HESS was designed. Finally, simulation experiments based on actual examples verified the effectiveness of the proposed methods.


Abstract This article makes two claims. The first is that Archimedes' On Floating Bodies included a punning reference, in its key diagrammatic figure AΠΟΛ: the precise purpose of the pun may not be recovered by us, but even so it remains a powerful example of the playful in Archimedes' writing. The second is that Apollonius could have been (contrary to what is now the accepted chronology of Greek mathematics) Archimedes' younger contemporary. The outcome could be that we find Archimedes addressing a playful, hidden message to Apollonius, providing us with a unique insight into the communication of Greek mathematics.


The invention relates to a processing method of preserved instant kelp and product, comprising the following steps: rehydrating dried kelp; cleaning; deodorizing; hardening; boiling (adding seasonings)-dehydrating; coiling; packaging; sterilizing; cooling; obtaining the finished product. The kelp is blanched for 3-5 minute using 1.0% plum syrup and soaked in 2.0% tea for 20 minute; then the soaked kelp is hardened for 3-5 minute in 0.2% CaCL[2]; the seasoned kelp is dehydrated in a 50 centidegree electric heat constant-temperature fan drying oven until the water activity is below 0.75; the kelp is folded in cylinder shape and the folded kelp is subjected to vacuum packaging and microwave sterilizing and then the finished product is obtained. The processing method has features of simple technique method, safety, low production cost, removal of fishy smell of kelp and tea fragrance or flower fragrance, kelp nutrient and special taste, namely a new-generation low-calorie health snack food.


This study empirically examined the effect of simulator platform motion on airline pilot recurrent training and evaluation. It is driven by the need for sound scientific data on the relationship between certain key modern device features and their effect on the transfer of pilot performance and behavior to and from the respective airplane. The experiment utilized an FAA qualified Level C simulator with six-degree-of-freedom synergistic motion and a wide angle high quality visual system. Experienced airline pilots were evaluated and trained in the simulator, half of them with and the other half without motion. Then the transfer of skills acquired by both groups during this training was tested in the simulator with the motion system turned on as a standin for the airplane (quasi-transfer). Every effort was made to avoid deficiencies in the research design identified in a review of prior studies, by measuring pilot stimulation and response, testing both maneuvers and pilots that are diagnostic of a need of motion, avoiding pilot and instructor bias, and ensuring sufficient statistical power to capture operationally relevant effects. The results of the analyses as well as their implications are presented in this paper. ____________________ * Portions of this work have been published as Ref. 1. Η Postdoctoral Associate, Department of Aeronautics and Astronautics, Member AIAA. Ι Engineering Psychologist. ∋ Consultant, experimental psychology. This paper is declared a work of the U.S. Government and is not subject to copyright protection in the United States. NOTATIONS FAA Federal Aviation Administration PTS FAA Practical Test Standards RTO Rejected Take-Off V1 Take-off decision speed; the minimum speed in the take-off, following a failure of the critical engine, at which the pilot can continue the take-off and achieve the required height above the take-off surface within the take-off distance. V1 cut Engine failure at or above V1 with continued take-off V2 Take-off safety speed; a speed that will provide at least the gradient of climb required by the airplane certification rules with the critical engine inoperative. PF Pilot Flying PNF Pilot Not Flying I/E Instructor/Evaluator n Sample size p Probability of null hypothesis (i.e., no effect of motion) r Pearson correlation coefficient STD Standard Deviation


Cultural heritage conservation and management can also be considered as a kind of risk management.The risk identification,assessment and treatment of cultural heritage so as to achieve a low cost and high efficiency of conservation and management can reflect the thoughts and ideas of preventive conservation.In the direction of Risk Management Theory,this paper works to put forward some important issues which present the monitoring work that faces through studying and analyzing the content and methods of the risk management of cultural heritage.All this will help with the launch of the monitoring work,building the framework of our cultural heritage monitoring system,and providing the reference for improving the conservation and management level of our cultural heritage.


The article discusses the use of ozone technology using lowintensity irrigation in Azerbaijan. The use of low-intensity irrigation using ozonized water is absolutely safe from the standpoint of environmental safety and this is its great advantage over other irrigation methods in agriculture. The developed irrigation technique at the same time creates an optimum water regime for plants of the root zone of the soil, ecological stability, and also an increase in yield.


Objective To evaluate whether endometrial thickness (EMT) change in response to progesterone has an effect on pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. Design Retrospective observational study. Setting Tertiary-care academic medical center. Participants 4465 infertile women undergoing their first FET between January 2010 and December 2015 in our center. Methods This observational study included 4465 patients undergoing their first FET cycles between January 2010 and December 2015. EMT was measured by transvaginal ultrasound one day before progesterone administration and on the day of FET to observe EMT change. Main outcome measures Clinical pregnancy rate (CPR) and the live birthrate (LBR) was discussed. Results Regardless of the endometrial preparation protocols such as artificial cycle, estrogen-progesterone replacement therapy (EP) or natural cycle (NC), EMT may increase, decrease or remain stable on the day of FET compared with that of one day before progesterone administration. CPR in EMT increase, decrease and stable groups were 48.4%, 51.3% and 50.7% in EP cycle versus 49.2%, 52.0% and 48.9% in NC cycle, showing no significant difference between the three groups in both cycles (P= 0.48, P= 0.49). LBR was 40.9%, 45.9% and 42.6% in EP cycle versus 44.2%, 44.8% and 42.1% in NC cycle, also showing no significant difference between the three groups in both cycles (P= 0.16, P= 0.66). In addition, CPR and LBR were not significantly associated with EMT increase. Concludes EMT may increase, decrease or remain stable on the day of FET as compared with that of one day before progesterone administration. Whatever change in EMT that occurs after progesterone administration has no significant effect on CPR and LBR in FET cycles.


Background: Morphologically and histopathologically, drug‐ and non‐drug‐induced maculopapular rashes can be almost indistinguishable. It has been postulated that Fas‐ligand (Fas‐L) is involved in the pathogenesis of drug rashes but not in the genesis of rashes, such as viral exanthems, that are not induced by medications.


This work empirically explores effective ex-ploiting of intermediate output from pre-trained language models (PrLMs) for language generation tasks. For this purpose, we propose an improved method to integrate public checkpoints of PrLMs for the most convenience and perform extensive experiments on 6 different kinds of PrLMs, including BERT, ELECTRA, GPT2, Multi-lingual BERT, and XLM RoBERTa. Evaluation with automatic met-rics shows that our approach significantly im-proves the generation quality on the generation tasks, up to 1.8 BLEU points for neural machine translation (Korean-to-English, Korean-to-Chinese) and 1.8 ROUGE points improvements for text summarization.


We study a communication game of common interest in which the sender observes one of innite types and sends one of nite messages


Series Foreword Preface Acknowledgments Chronology Introduction: Land, People, and History Traditional Islamic Culture and Modernization The Extended Family and Gender Roles Cuisine and Dress Social Customs, Rites of Passage and Holidays Communication and Mass Media Artistic Expression Glossary Bibliography Index


DOI: 10.21276/haya.2018.3.9.1 Abstract: The acceptability and utilization of a newly introduced Cassava (Manihot Esculenta) in Marigat, Baringo County, necessitated this study. This paper is drawn from a study that was conducted on Marigat to establish the level of utilization of the cassava roots. A total of 51 introduced cassava varieties were grown and all harvested at 16 months by KARI-Marigat. The study recommends that there should be greater efforts to promote cassava breeding for better food, nutrition and livelihoods that will enable people to live productive lives since cassava is staple in the diet of 90% of respondents in the study area. Deliberate efforts are necessary for leveraging agricultural research towards improved production of cassava roots with better culinary, nutritional and keeping qualities. This may enable communities in vulnerable areas such as Marigat to benefit from improved cassava varieties towards attaining Kenya's Vision 2030's for sustainable livelihoods and development.


1. The serum cholinesterase (ChE) activity in various blood disease generally shows a decreasing tendency, and it is marked in the acute form of leukemia. However, there can be recognized no special correlation between the serum ChE activity and the liver funktion and serum protein fractions. The serum ChE activity in blood diseases reflects well the clinical symptoms. 2. For the determination of the erythrocyte ChE activity in various blood diseases the author studied it by calculating the ChE activity value in a given unit of erythrocyte. As the result it has been found that in general the erythrocyte ChE activity in blood diseases shows an increasing tendency, and such a tendency is most marked in the acute form of leukemia. 3. When the administration of various drugs and blood transfusion prove effective on the fluctuations of the serum ChE activity and erythrocyte ChE activity in the course of treatment, these activities regain the normal level along with the recovery of anemia. The same trend can be recognized even in the experimental anemia.


This article examines the characteristics which distinguish the Republic from the Empire in Brazil. It explores the process of breaking with tradition and constructing a new symbolic universe capable of lending the emergent republican nation legitimacy. Political revolutions must deal at one and the same time with the organization of a new social and political life and with the construction of an imagery capable of reestablishing an equilibrium lost over time. When a new moment begun, it thus becomes necessary to evoke a remote time, a time where the roots - the true meaning of man and society - are to be found. This ubiqui tousness of revolutions, which are characterized by having one foot in the future and another in the past, has taken form in different ways. Dates, heroes, monuments, music, songs, and folklore come together in shaping a national memory, and if the latter has consistency, it proves an important reinforcement of social cohesion. When the Brazilian Republic was being built, monarchists and republicans struggled for the upper hand in devising a project for Brazil. The hypothesis sustained by the author is that the new symbolic universe was unable to lend the republican nation legitimacy. On the other hand, the monarchists, although not strong enough to restore the monarchy, were strong enough to guarantee the supremacy of their interpretation of Brazil.


The objective of this thesis will be to measure the practical limits of algorithms computing the exact Dodgson scores from a number of votes. While the problem itself is theoretically intractable, this work will feature five different solution which try different approaches to solve it in an effective manner. Additionally, three of them can be run in parallel which has the potential of drastically reducing the problem size.


The microstrip patch antenna is a popular printed resonant antenna for narrow-band microwave wireless link applications such as radio frequency identification (RFID) systems that require semi-hemispherical coverage. In this paper, a 865 MHz microstrip patch antenna fed by a microstrip line designed on a substrate is considerably studied and thoroughly analyzed. The antenna has been designed using the 3D High Frequency Structure Simulator (HFSS). The initial design provides a gain of 4.2 dBi, while the final optimized design achieved a total antenna gain of 5.6 dBi and a return loss or reflection coefficient (S11) of −35dB at 865 MHz for 116 mm patch length. Modeling and optimization of the presented microstrip patch antenna has produced results that are suitable for RFID applications.


Medical Resonance Imaging (MRI) is nonradioactive-based medical imaging that provides a superresolution of tissues. However, because of its complex nature using existing Deep Learning-based noise removal (i.e., Denoising) techniques, the reconstruction quality is poor and time-consuming. An extensive study shows very limited work has been done on Brain Multiple Sclerosis (MS) Lesions MRI. Designing an efficient noise removal technique will aid in improving MRI quality; thereby will aid in achieving better segmentation classification performance. In reducing computing time and enhancing image quality (i.e. reduce noise) this paper presents the Sparse Feature Aware Noise Removal (SFANR) technique for Brain MRI using Convolution Neural Network (CNN) architecture. A sparse-aware feature is incorporated into the patch-wise morphology learning model for removing noise in large-scale MRI MS lesion datasets. Experimental results demonstrated that our model SFANR outperforms all other state-of-art noise removal techniques in terms of Peak-SignalNoise-Ratio (PSNR), Structural Similarity Index Metric (SSIM) with less running time. Keywords—Convolution neural networks; deep learning; denoising; magnetic resonance imaging; morphology learning; multiple sclerosis; sparse features


Objective To study the value of preoperative neuroimaging in predicting the surgical plane of cleavage.Methods A prospective study of 43 cases of meningioma was performed,in which preoperative neuroimaging findings were correlated with the type of dissection plane(extrapial,subpial) encountered at surgery.Results There was a strong correlation between degree of peritumoral edema,hyperintensity of the tumor on T2-weighted images,cortical penetration,vascular supply from pial-cortical arteries,and cleavage of meningioma(P0.05).There was no correlation between tumoral location,size,shape,calcification,enhancement,cysts, dural tail,bone change and cleavage of meningioma(P0.05).Conclusion Peritumoral edema hyperintensity of the tumor on T2-weighted images,cortical penetration on preoperative CT and MR studies and tumor pial vascularization as seen on selective angiography can be used to predict the surgical plane of cleavage in meningioma.


Pregnant women with a positive HBsAg risk are very dangerous to the fetus in the mother's womb because it can threaten the safety of the mother and her baby. This assistance to babies is a key step in creating a new generation that is free of Hepatitis B. At the Wae Mbeleng Health Center, the number of cases of pregnant women with hepatitis B in 2020 was 40 cases, compared to the 2019 data, which was 35 cases. The high cases of hepatitis B infection in pregnant women at the Wae Mbeleng Public Health Center is a big concern for the public to be more aware of the dangers of this infection, both for mothers and their children. Therefore, the community needs to be given education about HBV, to break the chain of transmission of this infectious disease. The purpose of this activity is to increase public knowledge about the hepatitis B virus and increase awareness for screening. This service activity was carried out for 3 months. The participants of this activity were 30 pregnant women. The method of implementing the activity is through counseling, as a promotive and preventive effort in controlling hepatitis B virus infection. The results of this activity are an increase in public knowledge seen from the posttest. The ability of participants in mastering the material after the counseling activity can be said to be good (83.3%).


This study empirically tests whether Black's universal hedge ratio or regression hedge ratios work better than a simple unitary hedging strategy for hedging the exchange rate exposure in international equity portfolios in the presence of parameter uncertainty. When the ex ante universal hedge ratio or regression hedge ratios are estimated from historical data, it is quite possible that the performance results will be inferior to using a simple unitary hedge ratio. Two techniques for controlling estimation risk are used: a MVP technique due to Jobson and Korkie [16, 17]; and a Bayes-Stein (BST) technique derived by Jorion [19, 20]. The results indicate that when exchange risk is hedged using a unitary hedge ratio, an arbitrary universal hedge ratio of .77, or a uniquely determined universal hedge ratio, the average performance results are about the same, but inferior to unhedged international investment under all parameter estimation techniques. Moreover, the results are inferior to solely US investment. Even worse results obtain when regression hedge ratios are employed. In contrast, the Eun/Resnick [9] unitary hedging strategy performs very well under all parameter estimation techniques, yielding correspondingly superior average performance to all other hedging strategies and unhedged investment.


As a critical application in intelligent transportation systems, traffic state prediction still faces various challenges, such as unsatisfactory capability of utilizing multi-source data and modeling spatiotemporal network relevancies. Therefore, we propose a trajectory-based multi-task multi-graph convolutional network (Tr-MTMGN), a novel spatiotemporal deep learning framework for traffic state prediction on a citywide scale. This method firstly mines the underlying information from vehicle trajectories and designs a multi-graph convolution block to investigate spatial correlations. Sequentially, the multi-head self-attention layer is integrated into the multi-task learning framework to capture the temporal dependencies of the traffic state. The proposed model was evaluated on field data collected in Zhangzhou, China, and demonstrated superior performance when compared with existing state-of-the-art baselines.


This paper deals with the concepts of expert systems and machine learning Algorithms in the field of Artificial Intelligence. This expert system follows the tactic of task-based specification and it is independent in case of problem solving. Second thing is that, the machine learning technique is used to find the good optimal solution. This paper mainly focuses on the investigations on the diseases and treatment to the diseases which were affected to the chilli plants by using the mechanism Particle Swarm Optimization (PSO) algorithm. PSO is a heuristic global optimization method and also an optimization algorithm, which is based on swarm intelligence. Keywords— Expert System, Swarm, Knowledge Base, PSO, chilli expert system


activity which involves subjectivity and is tedious for the operator. The increasing number of drugs in testing makes it necessary to automate or semi automate the process. We propose an automated method for malaria thin blood smear inspection based on mathematical morphology tools operated on the grayscale image. The system is presented without a validation scheme and possibilities for the validation are proposed. Future work is outlined.


The rapid rise of DC side short-circuit fault current brings about great challenges on the development of modular multi-level converter based high voltage direct current (MMC-HVDC) grid. Starting from the nature that both fault current limiter and grounding mode limit current by increasing fault circuit resistance or inductance, this paper focuses on the analysis on influence of parameters in both fault current limiter and grounding mode on the evolution of DC short-circuit fault current of MMC-HVDC grid. A comprehensive current limiting effect analysis method based on transient energy flow (TEF) analysis is proposed from the perspective of macroscopic energy transfer and dissipation. In this method, two evaluation indexes of TEF suppression rate and suppression efficiency are proposed. Taking four-terminal bipolar MMC-HVDC grid as an example, the comprehensive limiting effect of TEF in each region with the change of parameters in both fault current limiter and grounding mode under the condition of DC side pole to ground fault is analyzed by PSCAD/EMTDC simulation system. The proposed method can provide a theoretical basis for the comprehensive optimization of fault current limiter and grounding mode for MMC-HVDC grid.


A two-step homogenisation method is developed in this study to upscale the elastic properties of ultra high performance fibre reinforced concrete (UHPFRC) from microscale to macroscale. The microstructure of the material is characterised using micro-indentation and X-ray computed tomography (XCT) tests. In the first step, the cement matrix with sand particles and small voids are homogenised using an analytical approach. In the second step, the asymptotic numerical homogenisation procedure is applied on the homogenised mortar matrix, steel fibres and large voids, which are modelled by realistic XCT image-based finite element meshes. The results are compared with experimental data. The effect of the unit cell size is also studied


There is certain diverse class of diagram that is found in a variety of branches of mathematics and which all share this property: there is a common scheme for translating all of these diagrams into useful functional code. These diagrams include Bayesian networks, quantum computer circuits [1], trace diagrams for multilinear algebra [2], Feynman diagrams and even knot diagrams [3]. I will show how a common thread lying behind these diagrams is the presence of a commutative monad and I will show how we can use this fact to translate these diagrams directly into Haskell code making use of do-notation for monads. I will also show a number of examples of such translated code at work and use it to solve problems ranging from Bayesian inference to the topological problem of untangling tangled strings. Along the way I hope to give a little insight into the subjects mentioned above and illustrate how a functional programming language can be a valuable tool in mathematical research and experimentation.


This study aims to develop a high-fidelity computer model of voice production which can employ the image-based realistic three-dimensional geometries of larynges and simulate the complex mechanical process of voice production and control, from muscle contraction to flow-structure-acoustics interactions. Such a model will advance our understanding of the relationship between muscle contraction, vocal fold posturing, vocal fold vibration, and final voice outcome, which has important clinical implications for voice management, training, and treatment. The key components of the model include a sharp-interface-immersed-boundary-method based impressible flow model, a finite-element method based nonlinear structural dynamics model and a hydrodynamics/acoustics splitting method based acoustics model. A Hill-based contractile model is coupled in the finite element analysis to capture the active response of vocal fold tissues, and a fiber-reinforced model is employed for the passive response. A series of validations have been performed. The coupled Hill-based model and fiber-reinforced model demonstrated a good agreement with literature experimental data for dynamics, concurrent tissue stimulation, and stretching. The flow-structure-acoustics interaction model was validated with excised canine experiments using realistic geometric and material properties. The simulations showed a good agreement on the fundamental frequency, vocal fold maximum divergent angle, flow rate, and intraglottal velocity and pressure fields.This study aims to develop a high-fidelity computer model of voice production which can employ the image-based realistic three-dimensional geometries of larynges and simulate the complex mechanical process of voice production and control, from muscle contraction to flow-structure-acoustics interactions. Such a model will advance our understanding of the relationship between muscle contraction, vocal fold posturing, vocal fold vibration, and final voice outcome, which has important clinical implications for voice management, training, and treatment. The key components of the model include a sharp-interface-immersed-boundary-method based impressible flow model, a finite-element method based nonlinear structural dynamics model and a hydrodynamics/acoustics splitting method based acoustics model. A Hill-based contractile model is coupled in the finite element analysis to capture the active response of vocal fold tissues, and a fiber-reinforced model is employed for the passive response. A series of validation...


Hydatidosis is a chronic infection that is important in medicine and veterinary medicine and is caused by infection with the larval stage of Echinococcine granulosus. The aim of this study was to investigate the effect of Moringa Peregrina seed extract on malondialdehyde as an
indicator of oxidative stress, proinflammatory TNF-α and IL-1β cytokines in order to detect the anti-inflammatory properties of the extract, the level of AST and ALT in the treatment groups. Detection of the effect of protecting the liver of Moringa Peregrina and the ability of the protoscolex to survive in vitro. For this purpose, 40 female mice were divided into 4 groups: the first group (control), the second group (receiving 0.5 cc protoscolex in the peritoneum), the third group (0.5 cc protoscolex + 200 mg/kg extract Of Moringa peregrina seedlings oral
for 3 month) and the fourth group (receiving 0.5 cc of protoscolex + 150 mg/kg albendazole oral for 3 month). Levels of malondialdehyde, TNF- α, IL-1β and liver enzymes in both treatment groups were significantly lower than those in the control group. The decrease in the level of factors measured in the Moringa Peregrina group therapy was close to the Albendazole group and no significant difference was observed between them. The effect of plant extract in dilutions of 750, 1500, 3000 and 4000 μg / ml with albendazole (as positive control) showed that the
dilution of 4000 had the highest effect on protoscolices at 24 and 48 hours, respectively, causing deaths of 82 and 91.67 percent of them were. The results of this study indicate that extract of grass seed oil can have a great effect in preventing recurrence of hydatid cyst in humans.


We present a cut-free tableau calculus with histories and variables for the EXPTIME-complete multi-modal logic of common knowledge (LCK). Our calculus constructs the tableau using only one pass, so proof-search for testing theoremhood of φ does not exhibit the worst-case EXPTIME-behaviour for all φ as in two-pass methods. Our calculus also does not contain a "finitized ω-rule" so that it detects cyclic branches as soon as they arise rather than by worst-case exponential branching with respect to the size of φ. Moreover, by retaining the rooted-tree form from traditional tableaux, our calculus becomes amenable to the vast array of optimisation techniques which have proved essential for "practical" automated reasoning in very expressive description logics. Our calculus forms the basis for developing a uniform framework for the family of all fix-point logics of common knowledge. However, there is still no "free lunch" as, in the worst case, our method exhibits 2EXPTIME-behaviour. A prototype implementation can be found at twb.rsise.anu.edu.au which allows users to test formulae via a simple graphical interface.


In 2012, KTMB launched a new fleet of China-made 6-car electric multiple units (EMUs) to augment their existing 3-car EMUs, the objective being to expand the capacity of its Klang Valley train commuter service from 33,000 to 95,000 passengers during the morning and afternoon peak hours. Due to significant expansion in train traffic density, it was essential to investigate whether the existing 25kV overhead centenary system (OCS) electrical network infrastructure could support the ensuing electrical power demands/loads due to the additional tractive effort of the 6-car trains and increased train traffic density. Traction power simulation study using MM-TRAIN software was conducted for this purpose. This paper illustrates the indispensable tool of traction power simulation software to access the performance of moving rail traction loads under normal (no outage) and under first emergency feeding conditions (n-1 outage contingency)


THE COVID-19 PANDEMIC has laid bare many of the flaws in our country's health care system, including a weak public health infrastructure, the terrible and persistent health and health care disparities experienced by people of color and other marginalized populations, our inability to nimbly redistribute vital equipment and human resources, the consequences of chronic underfunding of long-term care, and the utter absence of a functional collaboration between policy makers and the health care delivery system. In addition, the very design of how we deliver health care, who delivers it, and how it is compensated is exposed as inadequate, not only in the context of the pandemic but also for meaningful impact on the things we consider most important for the health of our citizens—primary care, preventive care, mental health, and social determinants of health. In their article on pharmacists as frontline responders during Covid-19, Thiessen et al describe a number of roles for pharmacists in ambulatory primary care that have become more available as resources and flexibility have been paired to allow for more innovation in response to the pandemic. In my 34 years as a family physician in rural Maine, first in solo practice and then with federally quali-


This article sets forth the substance and characteristics of the ancient library, and points out that fruitful regulations contributed to preserving valuable ancient books and records.


he effect of prolonged oxygen administration on Thost defense mechanisms in the lung was evaluated by comparing the intrapulmonary inactivation of gram positive and gram negative bacteria. Bacterial viability and radiotracer activity in the lungs of approximately 2500 mice were quantified six hours after exposure to an aerosol of radiolabeled ( 32P ) Staphylococcus aureus or Proteus mirabilis. Control animals (Poz.120 mm Hg) inactivated 92.9 percent of the inhaled staphylococci and 89.5 percent of the Proteus inoculum. Prolonged adrninistration of 100 percent oxygen (Poz.700 mm Hg) resulted in progressive impairment of antibacterial defenses proportional to the duration of oxygen exposure. In those animals in which intrapulmonary bacterial inactivation exceeded intrapulmonary bacterial replication, there was 78.5 percent and 78.2 percent inactivation of the Gram-positive and Gramnegative bacterial challenge, respectively, after 24 hours, 69.2 'percent and 66.9 percent inactivation after 48 hours and 56.0 percent and 47.3 percent inactivation after 72 hours exposure to oxygen. In


The effect of Quantity,length of Cemfiber on the workability of cement paste,mortar,ordinary concrete and high performance concrete has been studied.The results shows that:(1)Cemfiber maybe reduce the workability of concrete slightly;(2)Superfine powder(especially composite superfine powder)and the optimization of mix proportion may eliminate the disadvantage of Cemfibe.


For some patients with Parkinson disease, the neuropsychiatric complications are a greater source of morbidity than the motor dysfunction. This article focuses on the management of psychosis in Parkinson disease.


The main purpose of this study is to evaluate the relationship between capital adequacy, liquidity management, credit risk management, and financial performance with moderating role of bank ownership. This study used secondary data approach and collect 10 years panel data from 2012-2021 from the financial statements of the 15 Pakistani commercial banks. State software is used to analyze the data. Results show that there is a positive relationship between capital adequacy, liquidity management, credit risk management, and financial performance. But, on the other hand, there is not a strong moderating effect of bank ownership. The outcomes have been nearly the equal in all samples indicating that foreign ownership is not an important component of profitability in the quarter and as such a public coverage to encourage the presence of foreign banks might also, therefore, no longer yield any advantage in terms of financial institution profitability. This result is robust to the use of regulate- local measures whilst endogeneity concerns are controlled for. Furthermore, the findings imply that the stock liquidity issue of profits management is undoubtedly associated with future stock returns in Chinese corporations. Our outcomes reveal that the inventory liquidity thing of quick- termism in managerial choices performs a crucial role in figuring out destiny inventory returns.


T here are two books that sit quietly upon my sill and both are made and lived in Neverlands. I've read them through and through, and begin my review like this, in fairytale mode, because the books deserve nothing less, and quite a bit more. They deserve to be heard. One book, Jenny Boully's not merely because of the unknown that was stalking toward them, is set in the Never Never Land of Wendy and Peter Pan, that old tale, forever new in Boully's hands. And the other is Roxane Gay's book Ayiti, which is like a compass, showing us the way to the Haitian Diaspora—a diaspora that is neither north, south, east, nor west, but somewhere in between, and that leaves the needle wavering, if always, finally pointing toward the heart of Haiti. Both books, slim yet dense volumes, explore submerged worlds, both of them bending genre as they do so. Gay's publisher refers to Ayiti as a "unique blend of fiction, nonfiction, and poetry." Boully's work is classified under "fiction/poetry." Both books also examine the lives of women living, many times uncomfortably, in these submerged worlds—as if pushed beneath a line they desire to rise above. It is perhaps this aspect that I am most drawn to. R E V I E W


The high temperature resistant adhesive was prepared based on liquid polybutadiene epoxy resin(ELPB) cured by pyromellitic dianhydride(PMDA) and benzoyl peroxide(BPO). The research results showed that the influence of BPO on curing reaction of epoxy group in ELPB cured by PMDA was nonexistent,but the influence of BPO on curing reaction of double bond in ELPB was obvious,so BPO can more promote the IPN formation in the adhesive. The thermal stability of ELPB/PMDA/BPO adhesive was improved with elevation of crosslink density and heat resistant temperature was enhanced at about 8 ℃,but shear strength was decreased from about 15 MPa to 13 MPa because the brittleness of curing product was increased with elevation of crosslink density for Al-Al alloy bonding sample.


The successful establishment and expansion of invasive species may be linked to the behavior and dispersal tendency of individuals within an introduced population. To test the prediction that the boldest individuals, with the greatest dispersal tendency would be concentrated in the area of active range expansion, we compared the behavior, dispersal tendency, and metabolic rate of male round goby (Neogobius melanostomus) sampled from the expanding edge of their range with those sampled from an established area in the Trent–Severn Waterway, Ontario, Canada. Behavior and dispersal tendency were assessed in an artificial flume at 2 different water velocities using individuals caught in the spring and autumn of 2013, while resting metabolic rate (RMR) was determined using intermittent flow-through respirometry on fish collected in the autumn only. Round goby from the edge of their expanding range emerged from a shelter sooner, moved farther and faster in the flume, and had higher RMRs than individuals from established areas within the river. Neither water velocity nor season of capture was important in explaining the variation in time of emergence or movement. The higher proportion of bold individuals with high dispersal potential at invasion fronts facilitates further dispersal of round goby populations, and could help explain the rapid expansion of this species in North America and Western Europe. However, the benefits of bold phenotypes in terms of dispersal may be offset by increased energetic costs while at rest.


The purpose of this study was to examine the effectiveness of content·study skills instruction on the achievement of underprepared college students. The academic performance of two groups of underprepared freshmen was compared. The experimental group consisted of 40 students enrolled in an introductory history or psychology course who also participated in the Learning Skills Center support course The control group consisted of a like number of students enrolled in an introductory history or psychology course who did not participate in the support course at the Learning Skills Center. Dependent variables examined were grades earned in the content course and semester grade point average. Mean grade earned in the content course and mean semester grade point average was found for both groups and tested for significance at the .01 level using a 1 test for independent means. The data indicated a significant difference in mean content course grade earned, with the control group displaying superiority. The control group displayed a higher semester grade point average than the experimental group, but the difference was not significant. Successful academic achievement was reflected by high grades attained in the content course by some of the support students. Because all experimental subjects received satisfactory grades in the support course, transfer of learning may have been an influencing factor. The findings suggest that the experimental and control groups differed in significant unmeasured affective areas.


* Acknowledgements * Introduction: Worlding Men * 1. Family and Sexuality * 2. Ritual and Belief * 3. Work * 4. Governance and Conflict * 5. Migrations * 6. Masculinities in Motion


In this article I investigate how three ethnically diverse African refugee female adolescents navigated the intercultural complexity that contextualized their schooling in a small Northeast American city. Using ethnographically contextualized case study methodology, this article explores the participants' perceptions of the African and American cultural milieus that they straddled as refugee adolescents. Additionally, the article examines the strategies these refugee youth had to develop in order to transcend intercultural complexity and remain academically engaged. The findings suggested that the refugee adolescents demonstrated agency and a considerable degree of intercultural competency, which I conceptually juxtaposed here as Agentic Intercultural Competency in Schooling (AGICS). The findings further suggested that the AGICS concept was critical for these socially disadvantaged female adolescents to maintain high levels of scholastic engagement in the face of intercultural complexity.


Section headings: US Bilateral Relations: Japan and France. Regional and Global Economics Integration. Country Studies. Airline Deregulation. International Capital Flows. Technology and Competitiveness.


A cross sectional study was conducted to assess patient trust in the outpatient department (OPD) service at the Mother and Child Health Hospital, Vientiane Capital, Lao People's Democratic Republic (Lao PDR). 250 samples had all been OPD patients. Data was gathered by face to face interview from April 1 to 30, 2018. A structured questionnaire addressed general characteristics, doctor-patient relationships, perception to health service quality, and trust in OPD services. Data was analyzed by frequency, percentage, and chi-square test. Results revealed that most samples (96.4%) were female. 38.0% were aged from 25 to 30 years, 31.6% having received bachelor degree. 36.8% were civil servants, earning a monthly household income from two to five million Lak (236.39 to 590.98USD). Almost all were Lao Loum ethnicity and most lived in Vientiane, less than 10 kilometers from the hospital. 42.0% of samples had visited the OPD from twice Ref. code: 25606017090132VRA


Abstract The analysis of liver sonographic parameters of healthy men of the Podilski region of Ukraine who are of different somatotypes has revealed significant differences only in the thickness of the right lobe of the liver on inhalation, as well as in the width of the caudate lobe of the liver and the densitometry of the left lobe of the liver parenchyma on exhalation and during inhalation. No significant differences or trends between healthy men of different somatotypes were seen in the rest of the sonographic parameters of liver (oblique vertical size of the right lobe of the liver on exhalation and on inhalation, the thickness of the right lobe of the liver on exhalation, the cranio-caudal size of the left lobe of the liver on exhalation and inhalation, the thickness of the left lobe of the liver on exhalation and in inhalation, as well as the length of the caudate particle of the liver and densitometry of right lobe of liver parenchyma on exhalation and inhalation).


This guide provides basic information and principles on business management in schools. It includes the role of the school business manager in a potential site-based setting as well as a traditional, centrally-controlled setting. The book details: planning, budgeting, accounting and reporting, risk management, transportation services, school food service management, personnel services, and facilities operations and management.


Microhardness tester,optical microscope and electron back scattered diffraction technique were used to examine the property and microstructure of a low temperature tempered 20MnCr5 carburized gear.{110}α polar figure of Martensite was calculated according to the K-S and N-W orientation relationship.Orientation distribution of Martensite at the center of the gear was examined by electron back scattered diffraction technique.{110}α polar figure of Martensite in a selected prior austenite grain was plotted.The orientation distributes randomly in the whole scanned area,but distributes regularly in local area.The misorientation of the scanned area distributes mainly below 5° and above 45°.In order to characterize the orientation distribution law in local areas,stereographic projection of Martensite {110}α in a selected prior austenite area was plotted.The orientation relationship in the selected prior austenite is determined to be mainly N-W orientation by fitting the polar figure.Discrepancy between practical and theoretical orientation distribution is interpreted by cooperative strain mechanism.


Femtosecond laser-assisted cataract surgery (FLACS) was introduced in 2009 with the primary goals of improving cataract surgery outcomes and complication rates through increased automation and precision.1–3 Given these potential advantages, there was great interest in integrating FLACS in ophthalmology practices with one report documenting an increase from 19% to 43% of surgeons planning to offer laser-assisted cataract surgery from 2013 to 2015. Since then, however, adoption rates have plateaued, mostly due to concerns over efficacy and cost.4 While many had initially hoped that FLACS would lead to superior visual outcomes and fewer surgical complications, the clinical results have not shown significant improvement beyond conventional cataract surgery.5 Many review studies, including 2 recent publications, have discussed FLACS, highlighting its benefits, risks, and outcomes.6–13 Still, there remain open questions with newer studies that are not fully captured by these reviews. Therefore, we seek to provide an overview of what was known at the time of prior FLACS reviews and highlight incremental studies in recent years. We aim to identify what clinical benefits exist, potential new applications for FLACS, and the economic implications of its use.


As shown is stored Tenobe-somen, lipids in raw products of wheat flour may be hydrolyzed during long storage, and the change of lipids may have some effects on the gelatinization of wheat flour on cooking. Among the lipids tested, fatty acids and monoglycerides inhibited the swelling of wheat starch on heating, while egg yolk lecithin promoted it. Cottonseed oil had no significant effect. The inhibitory effect of fatty acids disappeared at a high temperature of 95°C. But when wheat flour was used instead of wheat starch, or when wheat starch was heated in the saline water extract of wheat flour, the inhibitory effect of fatty acids was observed even at 95°C. The same effect of fatty acids was observed when bovine serum albumin, bovine serum α-globulin or wheat


August, Wikemikong unceded territory, Manitoulin Island: Augusto Boal leads a ten-day workshop – the Rainbow Circle. Mixed Company hosts popular theatre workers from across the country. The native community hosts Mixed Company hosting popular theatre workers... great expectations: a world-famous director. A chance to work together as Canadians to address the issues raised by the constitutional debate. An invitation to work on native land with colleagues grounded in popular theatre techniques. An opportunity to debate the issues raised by working in Theatre of the Oppressed. A place to acknowledge our expertise and answer some of the questions.


The criteria for modifying the immunization schedule depends on the disease (load, frequency, morbidity and mortality, killing potential) of the vaccine (immunogenicity, efficacy, effectiveness, efficiency, compatibility, safety and assurance of supply) and society (impact on the population and the health system, perception of disease in the population). In Spain there are 19 different vaccine schedules that are not justified from a health, epidemiological, social or economic perspective. The Spanish Association of Paediatrics recommends: vaccinating against rotavirus from the sixth week, against papillomavirus in preadolescent girls, achieving universal pneumococcal ∗ Autor para correspondencia. Correo electronico: firstname.lastname@example.com (P. Martinez-Mateo). 1138-3593/$ – see front matter © 2011 Elsevier Espana, S.L. y SEMERGEN. Todos los derechos reservados. doi:10.1016/j.semerg.2011.10.022 Documento descargado de http://www.elsevier.es el 31/08/2016. Copia para uso personal, se prohibe la transmision de este documento por cualquier medio o formato.


Determining the physical location is a fundamental challenge in location based services and service robotics. This paper presents an approach to simultaneously determine the pose of a mobile robot and the positions of static wireless nodes based on a new technique to compute the angle of arrival of radio signals. For the overall localization process an Extended Kalman Filter is employed. For the initialization of the nodes positions a Particle Filter is used, to overcome the nonlinearity problem. Experiments show a mean accuracy for the position of the robot of 39mm for an indoor office environment and 80mm for an outdoor landscape environment.


Calculations of intermodulation (IM) noise and input/output power-transfer characteristics for a number of different nonlinear Solid-State Power Amplifiers (SSPAs) are found to be in very good agreement with measurements. The calculations are based on the measured AM/AM and AM/PM characteristics, and include results of a computer simulation, and analytical results based on modeling the SSPA as an ideal envelope limiter. The results demonstrate that the calculations predict wideband performance characteristics of nonlinear amplifiers for arbitrary input signal configurations and operating conditions, as well as provide a basis for comparison against which anomalous behavior can be identified. Earlier results, in which anomalous behavior of an SSPA was observed to result in significant performance degradation, are discussed in the light of these new results. A simple analytical criterion is developed for evaluating measurements to identify such degradation. The effect of AM/PM conversion is investigated and found to cause significant degradation in IM performance only at low power levels for typical SSPAs. In the vicinity of saturation, and above, the contribution to IM noise due to AM/PM conversion is found to be very small in comparison with that due to the saturating AM/AM characteristic.


Hydraulic fracturing (fracking) is a process used for the stimulation and production of ultra‐low permeability shale gas and tight oil resources. Fracking poses two main risks to groundwater quality: (1) stray gas migration and (2) potential contamination from chemical and fluid spills. Risk assessment is complicated by the lack of predrilling baseline measurements, limited access to well sites and industry data, the constant introduction of new chemical additives to frack fluids, and difficulties comparing data sets obtained by different sampling and analytical methods. Specific recommendations to reduce uncertainties and meet science needs for better assessment of groundwater risks include improving data‐sharing among researchers, adopting standardized methodologies, collecting predrilling baseline data, installing dedicated monitoring wells, developing shale‐specific environmental indicators, and providing greater access to field sites, samples, and industry data to the research community.


Currently, the main problem for Helicon Plasma Thrusters (HPTs) is the lack of knowledge about its operation, and thus there are not proper guidelines for its design. In this paper, a novel 2D asymmetric code is proposed as a tool that could improve the understating of the physics behind and acts as a guidance that leads to a competitive design. This code fully models all the aspects of the plasma discharge. In the code, a hybrid approach is considered for the plasma production and transport: a fluid model is used for electrons and a Particle-In-Cell model for heavy species, which is a trade-off between computational feasibility and solution accuracy. As to the plasma-wave interaction, a frequency domain Finite Difference model based on a cold plasma is considered. The structure of the code and the integration of the different models are explained. The main difficulties in the development of this code are to find numerical algorithms that handle properly the low collisional and anisotropic electron fluid and the complex modelling of the plasma-wave interaction. The advances achieved in these difficulties are presented and discussed. After that, in order to show the capability of the code and its potential application as a guidance in real designs, this is used to run a simulation for a HPT thruster with a realistic configuration. From the simulation, 2D color maps of the discharge properties and thruster performances are obtained and studied. The study shows that the results are consistent physically and has allowed to propose improvements to its configuration.


GDS J033218.92-275302.7 (here GS-14) is a $z\sim5.5$ galaxy detected in [CII] as part of the ALPINE survey with unusual UV spectral features that have been interpreted as signatures of either a double stellar population or of an active galactic nucleus (AGN). We exploited the multi-wavelength coverage of GS-14 to investigate the properties and the origin of its emission. We performed UV-to-NIR SED-fitting, with single/double stellar population and/or AGN component. We analyzed the VIMOS spectrum, which shows highly-ionized emission lines (Ovi, Nv, and Niv). The line properties have been compared with those observed in galaxies and AGN, and with the predictions from radiation transfer models for star-forming galaxies, AGN, and shocks. The SED-fitting provides a total stellar mass of $M_*=(4 \pm 1) \times 10^{10} M_\odot$, an age of the main stellar population of $\sim670 Myr$ and a recent short (8 Myr) burst of star formation (SF) of $\sim 90 M_\odot yr^{-1}$. The Nv line has a characteristic P-Cygni profile, which suggests a $\sim 3 Myr$ old population of stars with a mass of $\sim 5 \times10^{7} M_\odot$. The Nv profile also shows evidence for an additional component of nebular emission. The comparison of the line ratios with theoretical models allows us to associate the emission with SF or AGN, but the strong radiation field required to ionize the Ovi is more commonly related to AGN activity. We found evidence for an old and already evolved stellar population at $z\sim 5.5$ and show that the galaxy is experiencing a second short burst of SF. In addition, GS-14 carries signatures of obscured AGN activity. The AGN could be responsible for the short depletion time of this galaxy, thus making GS-14 one of the two ALPINE sources with hints of an active nucleus and an interesting target for future follow-ups.


The purified inhibitory subunit of rabbit skeletal muscle troponin, TN-I (M.W. 24,000)+ was phosphorylated by phosphorylase kinase in the presence of Mg ATp 2- and Ca 2 , and by protein kinase in the presence of Mg-ATp 2- and cyclic AMP2. Phosphorylase phosphatase removed all the phosphate incorporated by either kinase. The primary site of phosphorylation of TN-I by phosphorylase kinase was a threonine residue, as compared to a serine residue in phosphorylase a. Comparison of kinetic parameters for both kinases and the phosphatase with TN-I and other protein sub strates showed it to be a favorable substrate. The tropomyosin binding subunit of troponin, TN-T (M.W. 38,000) was also phosphorylated by phosphorylase kinase, but not protein kinase, and dephosphorylated by phosphorylase phosphatase. Incubation of troponin with Mg-ATp 2 - and either phosphorylase kinase or protein kinase result ed in incorporation of phosphate into both TN-I and TN-T with both kinases. All of the phosphate incorporated was removed by phosphorylase phosphatase. Troponin is a protein which is necessary for the Ca 2+ sensitivity of acto myosin ATPase. In the absence of Ca 2 + troponin interacts with actomyosin to inhibit ATPase activity whereas in the presence of Ca 2+ there is a stimulation of the ATPase (Ebashi and Kodama, 1966). Troponin has been shown to be composed of three subunits: TN-I (M.W. 24,000), which inhibits actomyosin ATPase in the presence or absence of Ca 2+; TN-C (M.W. 18,000), which binds Ca 2+ and blocks the inhibition of ATPase by TN-I in the presence or absence of Ca 2+; and TN-T (M.W. 38,000), which binds to tropomyosin and restores the original Ca 2+ sensitizing activity of troponin when added to TN-I and TN-C (Greaser and Gergely, 1971; Hartshorne and Dreizen, 1973;


In this pilot study, data obtained from a population of healthy younger (18-24 yrs), middle aged (25-64 yrs) and older drivers (65+ yrs) were used to establish normative values of parameters commonly documented during simulated driving. The older drivers' performances in most of the driving skills assessed were significantly worse than those of the other 2 classes of drivers. In line with previous studies, our data showed deterioration of driving skills with increasing age. The test-retest reliability of the driving simulation parameters were moderate to very high.


We investigate direct-modulated waveguide-coupled microspiral disk lasers for on-chip optical interconnects. Microspiral resonators, with a rotationally asymmetric shape and a waveguide directly gapless coupled to the notch, offer a compact unidirectional-emission on-chip laser source. We employ spatially selective injection by means of a ring-shaped p-contact on top of the microdisk rim region to selectively inject current to the whispering-gallery-like modes and thus enhance the laser performance. Here we report room-temperature continuous-wave electrically injected AlGaInAs/InP waveguide-coupled microspiral disk lasers with a disk radius of 30 and 40 μm. For a 30μm microspiral disk laser gaplessly coupled with a 100μm-long passive waveguide that is directly connected to an on-chip AlGaInAs/InP photodiode, we estimate a laser output power of at least 200 μW upon a 70mA injection. We realize small-signal modulation with a 3dB bandwidth exceeding 10 GHz for the 30μm microspiral disk. We demonstrate an open eye diagram at 15 Gbit/s with a bias current of 90 mA at a stage temperature of 15°C. Device requirements for optical interconnects to silicon chips, " Proc.silicon photonics for on-chip and intra-chip optical interconnects, " Laser Photonics Rev. Whispering-gallery mode microdisk lasers, " Appl. Stimulated emission and lasing in whispering-gallery modes of GaN microdisk cavities, " Appl. Optically pumped InAs quantum dot microdisk lasers, " Appl. Phys. Lett. 76(24), 3519–3521 (2000). 7. T. Baba and D. Sano, " Low-threshold lasing and Purcell effect in microdisk lasers at room temperature, " IEEE J. Electrically pumped InP-based microdisk lasers integrated with a nanophotonic silicon-on-insulator waveguide circuit, " Opt. Whispering gallery resonances in semiconductor micropillars, " Appl. Whispering gallery mode lasing in high quality GaAsAlAs pillar, " Appl. Directional emission from asymmetric resonant cavities, " Opt. Observation of scarred modes in asymmetrically deformed microcylinder lasers, " Phys. Highly directional emission from few-micron-size elliptical microdisks, " Appl. from InGaN multiple-quantum-well spiral-shaped micropillars, " Appl. Current-injection spiral-shaped microcavity disk laser diodes with unidirectional emission, " Appl. Quasiscarred resonances in a spiral-shaped microcavity, " Phys. Single-mode laser action in quantum cascade lasers with spiral-shaped chaotic resonators, " Appl. Continuous wave operation of a spiral-shaped microcavity laser, " Appl. Investigation of mode coupling in a microdisk resonator for realizing directional emission, " Opt. Channeling chaotic rays into waveguides for efficient collection of microcavity emission, " Phys. Emission characteristics of a spiral-shaped microcavity laser with a waveguide, " J. AlGaInAs/InP waveguide-coupled unidirectional-emission microspiral lasers for on-chip optical interconnects, " in CLEO (2013), paper …


Disk image of a floppy disk used by Deborah Holland, containing approximately 21 files dating from May 1990. These documents include FOIA (Freedom of Information Act) requests, letters to members of Congress, and internal NCI memos.


Introduction Biology and oral cancer Evaluating the patient with squamous cell carcinoma of the mouth General principles of cancer surgery Ablative cancer surgery of the mouth and jaws Neck dissections General principles of reconstructive surgery Reconstruction of the mouth and jaws following ablative cancer surgery Radiotherapy Other treatment modalities.


This article develops a framework, drawn from earlier work by education scholars, as well as broader theoretical insights on advocacy and policymaking developed by political scientists, for thinking about education politics in the post-No Child Left Behind era. The authors use this framework to examine the evolution of the national education policy arena over the past ten years. The authors describe the key political dynamics and actors which drove education policymaking at the national level for forty years after the passage of ESEA in 1965; and then explain the forces which transformed this educational status quo in the 1990s and led to the passage of NCLB in 2001. Finally, the article analyzes how the law itself has altered the national politics of education, including the growth and diversification of the think tank sector in the inter-reauthorization period. Implications for the future of federal education policy and politics are considered.


The elastic modulus of TiNi alloy was tailored by electroplastic rolling deformation and the effects of rolling strain and electropulse duration on the elastic modulus of electroplastic rolled TiNi alloy were systematically investigated. With rolling strain increasing from 0 to 1.70, the elastic modulus decreases from 61 to 30 GPa, which can be attributed to the increase in dislocation density and deformation-induced low modulus B19′ martensite phase. With electropulse duration increasing from 80 to 120 µs, the elastic modulus first decreases due to the volume fraction increase in low modulus B19′ martensite phase and then slightly increases on account of the dynamic recovery of dislocation and reverse martensite transformation resulted from electroplastic effect induced by high-energy electropulse.


The essence of communication between the addresser and the addresser relies on understanding the meaning of linguistic message . Meaning may be prone to ambiguity and misunderstanding . In this case , language has its own means to safeguard meaning against such phenomena. The research aims at investigating some aspects of this topic in order to reveal the close connectivity between syntax and semantics . So the research studies : the methods of ensuring meaning clarification , and their role in the structure of the Quranic sentenece Special attention is given to intonation , context , and intensification. The research then tackles some aspects of avoiding ambiguity in the Quranic sentence . These aspects include the shift from one mode to another , using noun in place of pronoun , foregrounding and back grounding , expanding without affecting the structure of the sentence and the structural and stylistic changes.


Gel polymer electrolytes (GPEs) have potential as substitutes for liquid electrolytes in lithium-metal batteries (LMBs). Their semi-solid state also makes GPEs suitable for various applications, including wearables and flexible electronics. Here, we report the initiation of ring-opening polymerization of 1,3-dioxolane (DOL) by Lewis acid and the introduction of diluent 1,1,2,2-tetrafluoroethyl 2,2,3,3-tetrafluoropropyl ether (TTE) to regulate electrolyte structure for a more stable interface. This diluent-blended GPE exhibits enhanced electrochemical stability and ion transport properties compared to a blank version without it. Fourier transform infrared spectroscopy (FT-IR) and Nuclear magnetic resonance (NMR) proved the effectiveness of monomer polymerization and further determined the molecular weight distribution of polymerization by gel permeation chromatography (GPC). Experimental and simulation results show that the addition of TTE enhances ion association and tends to distribute on the anode surface to construct a robust and low-impedance SEI. Thus, the polymer battery achieves 5C charge-discharge at room temperature and 200 cycles at low temperature -20°C. The study presents an effective approach for regulating solvation structures in GPEs, promoting advancements in the future design of GPE-based LMBs.


The inner electric potential distribution of CdZnTe detector was derived by applying poisson equation with the first type boundary condition,and the polarization effect of CdZnTe pixellated detector for imaging 137 Csγsource was investigated.The results of numerical calculation and experiment indicate that electric potential distribution is mainly influenced by applied bias for low charge density in CdZnTe crystal and, in turn,there is linear relationship between electric potential distribution and applied bias that induces uniform electric field under low irradiated flux.However,the electric potential appears polarization phenomenon,and the electric field in CdZnTe crystal is distorted when CdZnTe detector is under high irradiated flux.Consequently,charge carriers in CdZnTe crystal drift towards the edge pixels of irradiated region,and hence, the shut-off central pixels are surrounded by a ring of low counting pixels.The polarization effect indeed deteriorates the performance of CdZnTe detector severely and the event counts of edge pixels for irradiated region reduce about 70%.


Taking retailer's marketing investment level as endogenous variable of integrated inventory model for deteriorating items.This paper studies how supply chain firms make production,ordering and marketing decisions to maximize the whole supply chain profits.Then an algorithm is developed to solve this problem.Finally,by numerical analysis this paper examines the effect of the sensitivity of demand to marketing investment and the product's deteriorating rate on supply chain optimal strategy and profits.


Background: the deficiency of 5,10-Methylenetetrahydrofolate reductase (MTHFR) constitutes a rare and severe metabolic disease and is included in most expanded newborn screening (NBS) programs worldwide. Patients with severe MTHFR deficiency develop neurological disorders and premature vascular disease. Timely diagnosis through NBS allows early treatment, resulting in improved outcomes. Methods: we report the diagnostic yield of genetic testing for MTHFR deficiency diagnosis, in a reference Centre of Southern Italy between 2017 and 2022. MTHFR deficiency was suspected in four newborns showing hypomethioninemia and hyperhomocysteinemia; otherwise, one patient born in pre-screening era showed clinical symptoms and laboratory signs that prompted to perform genetic testing for MTHFR deficiency. Results: molecular analysis of the MTHFR gene revealed a genotype compatible with MTHFR deficiency in two NBS-positive newborns and in the symptomatic patient. This allowed for promptly beginning the adequate metabolic therapy. Conclusions: our results strongly support the need for genetic testing to quickly support the definitive diagnosis of MTHFR deficiency and start therapy. Furthermore, our study extends knowledge of the molecular epidemiology of MTHFR deficiency by identifying a novel mutation in the MTHFR gene.


The paper introduces the significance and method of the application of Demand Side Management (DSM) in enterprise illumination economizing, and deals with the use of Excel in the calculation of cost and benefit, and proves the actual benefit with the illumination data of the enterprises.


The in vivo feeding trial was conducted on 6 weeks with 126 Tetra SL laying hens, 56-week old, assigned to 3 groups. The layers were housed in an experimental hall with controlled microclimate, in three-tier digestibility cages (2 layers per cage) which allowed the daily recording of the feed intake and excreta. All hens received a conventional compound feed (C), based on corn and soybean meal, which contained 2750 kcal/kg metabolizable energy and 17.50% crude protein. Each experimental group had as supplement one fat and one antioxidant vegetal source, rapeseed meal and grapeseed meal (RGM) respectively flaxseed meal and buckthorn meal (FBM). The balance study was conducted for 5 days, on the last experimental week. During this period, average weights from each cage (6 samples per group) of feed and excreta were recorded, collected and sampled for: dry matter (DM), crude protein (CP), ether extractives (EE), crude fibre (CF) ash and amino acids determinations from feeds. The layers from FBM group had significantly (P<0.05) higher concentration of ingested, excreted and digested amount of CP and the lowest (P≤0.05) EE and CF absorption coefficient. Significantly higher (P<0.05) values for ingested, excreted, digested and absorption coefficient of CF nutrient, was registered for RGM group.


A new energy function is proposed for forming self-adapting ordered representations of input samples in a multilayer perceptron. Simulation results on unconstrained handwritten digit recognition give a better invariance extraction for this model than for several other models.


The present invention aims to provide a fast-acting and and persistent certain therapeutic agents for chronic intractable otitis externa. The present invention, as an active ingredient interferon α a (IFN [alpha]), a composition for the prevention and / or treatment of chronic intractable otitis externa, pharmaceutical compositions, to provide a food and feed. The compositions of the present invention by oral administration, inhibited chronic intractable otitis externa, mitigation, enables treatment and prevention. IFNα in the present invention can obtain a sufficient effect by administration of trace.


Description from Mapping Maryland: "Morse (1794-1871), publisher of a religious newspaper, expanded into map printing and in 1834 invented the wax engraving process (cerography), a technique soon to be used widely by other map-makers. This view of the tri-state area appears in Morse's "Universal Atlas".


County of Hood does not discriminate on the basis of disability in the admission or access to, or treatment or employment in, its programs or activities. Personnel Director, Personnel and Governmental Affairs Dept. 1414 W. Pearl St., Granbury, Texas 76048, phone 817-408-3450 has been designated to coordinate compliance with the non-discrimination requirements in Section 35.107 of the Department of Justice regulations. *Information concerning the provisions of the Americans with Disabilities Act, and the rights provided thereunder, is available from the Personnel Director.


In order to understand the effects of electron-phonon coupling and Coulomb interactions in angle-resolved photoemission spectroscopy (ARPES), a spin-1/2 Hubbard-Holstein model at half-filling is theoretically investigated by means of the mean field theory and classical Monte Carlo simulation method. It shows that the spectral shape of the one-dimensional system is significantly modified by the electron-phonon coupling and Coulomb interactions. The suppression of charge-density wave in one-dimensional system has been ascribed to the short-range Coulomb repulsion and thermal lattice fluctuations. The competition between these interactions can induce zero energy gaps in APPES as well as complete cancellation of charge or spin ordering.


The axial anomaly leads to the violation of separate number conservation laws for left- and right-handed massless chiral (or Weyl-) fermions. For a certain class of gapless semiconductors, for which the low-energy band structure is described in terms of Weyl-fermions, the application of a magnetic field parallel to the electrical current is predicted to induce a large suppression of the electrical resistivity. To date, there is no concrete experimental realization of a Weyl semi-metal or unambiguous evidence for this field-induced phenomenon. Here, we report the observation of a very large negative magnetoresistance in the extremely clean quasi-two-dimensional metal PdCoO$_2$. Our experimental study provides strong support for a scenario where this unconventional response results from the axial anomaly of field-induced quasi-one-dimensional conduction channels. The observation of this effect in PdCoO$_2$ demonstrates that the axial anomaly is a general feature of the longitudinal magnetotransport of clean and weakly correlated three-dimensional metals.


Gravitational lensing affects observed cosmological correlation functions because observed images do not coincide with true source locations. We treat this universal effect in a general way here, deriving a single formula that can be used to determine to what extent this effect distorts any correlation function. We then apply the general formula to the correlation functions of galaxies, the 21-cm radiation field, and the cosmic microwave background.