Preparing personnel to meet the vocational programming needs of handicapped and disadvantaged learners has begun to emerge as a significant priority in both the fields of vocational education and special education. The shifting of societal concerns, as reflected in favorable human rights litigation and new federal legislation has caused the educational community to re-examine the educational and employment potentials of persons who have unique educational needs. Within the past two years, the increased need for addressing these developments in the training of educational personnel has been acknowledged by the funding of three national conferences plus several regional and state-


Aim : The study aimed at determining the tooth cleaning devices, reasons influencing the choice of such devices, which tooth cleaning device gave the best oral hygiene and to ascertain the oral health status of the community. Methods : This cross sectional study involved 147 participants resident in Isu Awaa, in Enugu state, Nigeria, who were present for an oral health educational activity. Data collection was done using a structured pre-tested questionnaire administered by the dental team. Data obtained were on the participants' demographic details, tooth cleaning devices used, and reasons for their choices. The caries status was measured using modified DMFT index, the periodontal treatment needs by CPITN and the Oral hygiene status by Simplified OHI. The data collected were analyzed using SPSS version 15. Results : The choice of toothbrush was mostly attributed to "good result" while choice of chewing stick was hinged on availability and traditional beliefs. The mean DMFT and OHI-Scores were 2.0 ± 2.82 and 2.46 ± 0.93 respectively, while 105 (71.4%) participants needed deep scaling and curettage. Conclusion : The use of chewing stick in this community is still very popular, although the participants believed that better results were obtained by using toothbrush. To help improve and maintain good oral hygiene, routine community based oral health education on proper use of either the chewing stick or tooth brush is highly recommended. Key words : Oral, Hygiene, Health, Practices


The c‐mos proto‐oncogene exists as a maternal mRNA in mammalian oocytes, in that it has been shown to accumulate in mouse oocytes during the growth phase and to be present at high levels in fully grown oocytes. The function of c‐mos during the subsequent development of the oocytes and embryos was examined by determining the fate of the oocyte c‐mos mRNAs by in situ hybridization and Northern blot hybridization analysis. A substantial decrease in the levels of c‐mos transcripts was observed in oocytes undergoing meiotic maturation. By the two‐cell stage, levels of c‐mos transcripts dropped to below the limits of detection using in situ hybridization. c‐mos transcripts remained undectable through the blastocyst stage of embryogenesis. Analysis of meiotic maturation in vitro permitted finer temporal resolution of the initial drop in c‐mos levels. Between approximately 7 and 17 h of culture, the amount of c‐mos mRNA fell to 18‐43% of the levels found in the fully grown oocyte. This interval corresponds to the progression of meiotic maturation from metaphase I to metaphase II. Our in vivo studies showed that ovulation per se is not the stimulus for the drop in c‐mos transcript levels, since preovulatory metaphase II oocytes exhibited this decline to a degree comparable to that of ovulated metaphase II oocytes. The development specificity of c‐mos transcript levels suggests a role of this putative serine kinase in the meiotic maturation of mammalian germ cells.


ABSTRACT Gradually community and scholarly support for large-scale sport events is declining as sustainability and efficiency are becoming primary concerns. Thus, a drive for the creation of small-scale event portfolios that comply with a community's resources and infrastructure is developing. In the current study, a portfolio of four small-scale mountain bike events located in the Northwest United States were investigated to better understand their impact on the local economy. An online survey was conducted after each event that assessed visitor spending, travel behavior, and participant demographics resulting in a total sample of N = 614. Through general linear modeling, chi-square testing, and multiple regression each of the four events were compared with each other and determinants of visitor expenditure were tested. The results demonstrated the four events significantly differed in regards to total expenditure, daily expenditure, daily expenditure per person, trip duration, amount of travel party event participants, travel distance, age, income, and lodging type/location. Overall expenditure and daily expenditure per person were found to be significantly determined by participant travel distance, travel party size, trip duration, and income. Managerial implications derived from these results for destinations and event organizers are discussed.


Contents Chapter 1. Eigenvalues and the Laplacian of a graph 1 1.1. Introduction 1 1.2. The Laplacian and eigenvalues 2 1.3. Basic facts about the spectrum of a graph 6


A method for producing polyamide fine particles by polymerizing monomers (A) for a polyamide in the presence of a polymer (B) at a temperature not lower than the crystallization temperature of a polyamide to be obtained, wherein the monomers (A) for a polyamide and the polymer (B) are uniformly dissolved when the polymerization starts and polyamide fine particles are precipitated after the polymerization. Polyamide fine particles which have a number average particle diameter of 0.1-100 μm, a sphericity of 90 or more, a particle diameter distribution index of 3.0 or less, a linseed oil absorption of 100 mL/100 g or less and a crystallization temperature of 150°C or higher. Especially, the present invention is able to provide a polyamide having a high crystallization temperature in the form of fine particles which have smooth surfaces, a narrow particle size distribution and a high sphericity.


Bearing Chambers in Aero-Engines are located near the rolling-element type of bearings which support the shafts and accomodate the resulting thrust loads. One of the main task of the bearing chambers is, beside an efficient scavenging of the lubricating oil, the cooling of the hot compartments. A very complex two-phase air-oil flow takes usually place in these bearing chambers consisting of oil droplet-laden air flows and shear-driven liquid wall films. The interaction of the droplets with the wall films is significantly influencing the wall heat transfer and the cooling performance of these systems. For this reason, a detailed characterization and modelling of the mass and momentum exchange between droplets and wall films for the unique impingement parameter range in bearing chambers is inevitable.
This scientific report investigates the oil droplet impact dynamics for typical impingement regimes relevant to aero-engine bearing chambers. The application of a Direct Numerical Simulation (DNS) technique based on the Volume-of-Fluid (VOF) method and coupled with a gradient-based adaptive mesh refinement (AMR) technique allowed to characterize the drop impact dynamics during various single micro- and millimeter drop impacts onto thin and thick films. With the help of a special numerical treatment, a self-perturbing mechanism is installed that leads to the correct resolution of the crown disintegration process. The numerical methodology was thoroughly validated using the experimental results of millimeter sized drop impacts onto deep liquid pools. These results were developed with an enhanced back-illuminated high-speed imaging and Particle Tracking Velocimetry (PTV) technique.
New insights into the cavity penetration, the crown's breakup dynamics and the secondary droplet characteristics following a single drop impact have been developed with the help of the isolated variation of different parameters of influence. Particularly the influence of the Froude number, the impingement angle, and the cavity-wall interaction delivered results to date not reported in scientific literature. Beside the advances in fundamental physics describing the drop impact dynamics with the help of the numerical and experimental results, a set of correlations could also be derived. From these correlations, a drop-film interaction model was formulated that is suitable for the parameter range found in bearing chambers.


New data for the forward differential cross section ${(\frac{d\ensuremath{\sigma}}{\mathrm{dt}})}_{0}^{\mathrm{CEX}}$ and for $\ensuremath{\Delta}\ensuremath{\sigma}\ensuremath{\equiv}{\ensuremath{\sigma}}_{T}({\ensuremath{\pi}}^{\ensuremath{-}}p)\ensuremath{-}{\ensuremath{\sigma}}_{T}({\ensuremath{\pi}}^{+}p)$ at 20 to 200 GeV/c are analyzed by means of the $\ensuremath{\rho}+{\ensuremath{\rho}}^{\ensuremath{'}}$ Regge-pole exchange model with no absorptive cut. In terms of ${(\frac{d\ensuremath{\sigma}}{\mathrm{dt}})}_{0}$, $\ensuremath{\Delta}\ensuremath{\sigma}$, and $r = \frac{\mathrm{Re}{A}^{\ensuremath{'}}}{\mathrm{Im}{A}^{\ensuremath{'}}}$, the $\ensuremath{\rho}+{\ensuremath{\rho}}^{\ensuremath{'}}$ model with the $\ensuremath{\rho}$ trajectory of $0.466l{\ensuremath{\alpha}}_{\ensuremath{\rho}}(0)l0.476$ and the ${\ensuremath{\rho}}^{\ensuremath{'}}$ trajectory of $\ensuremath{-}1.9l{\ensuremath{\alpha}}_{{\ensuremath{\rho}}^{\ensuremath{'}}}(0)l\ensuremath{-}1.3$ is more promising than such a model with $\ensuremath{-}0.2l{\ensuremath{\alpha}}_{{\ensuremath{\rho}}^{\ensuremath{'}}}(0)l0$. The prediction extrapolated to 1000 GeV/c suggests that another type of term should be added to the real or imaginary part of the amplitude.


Primary objective of the company is to reach the business success. Competitors have the same objective. Only the companies that really meet the consumer's needs and demands survive in the competitive struggle. The company who succeeds in it, has the possibility to achieve the competitive advantage as well. The company has to have the adequate marketing strategy in order to fulfill the marketing objectives and achieve the competitive advantage. The marketing strategy should be flexible and properly implemented to fulfill the expected results. The best solution is developing the credible strategies. Researching of the strategic marketing literature, the authors have noted down that the greater attention is given to the formulation than the implementation of the marketing strategy. In this text, focus is on the research of the marketing strategy implementation as a significant factor of the competitive advantage. The traditional concept of the marketing strategy implementation is taken into consideration first, as well as the risks the enterprise is facing with in that case. Thereafter, the testing and developing of the credible marketing strategy is represented, as well as the problems the enterprise is facing with in the implementation. Finally, the executive skills and control are analyzed as important factors of the successful implementation of the marketing strategy. .


In this paper, we explore the impact of wind generation on isolated power systems, using the system of Cyprus (an island) as a case study. Since 2010, Cyprus has been facing the challenge of integrating intermittent wind generation, while maintaining a secure and economical power system operation. This integration has raised the reserves requirements, and has undermined the ability to accurately track the unit commitment and dispatch day-ahead plan in real time. To evaluate the impact of these effects, we model the daily electrical power system operation of Cyprus as a day-ahead unit commitment and economic dispatch problem, and simulate the system for a long horizon of many days, under different scenarios of wind penetration, using historical data of wind generation.


Based on the domestic and foreign landscape construction in waterfront district,and on-the-spot investigation in series of landscape of Xiang river located in Changsha of Hunan province,also reference research,the authors put forward a landscape model titled as "One river-Two banks-Three bridges",concluded the planning idea of this big garden model and layout of its landscape elements,The analysis showed that the features of this major landscape model included large space of skip distance,ground-air integration,gathering and scattering fine conformity,and multicultural assembly.It played an important role and run key functions in city card,public leisure,culture spreading,and traffic service.The authors probed and proposed its extending significance in landscape making.


The Needle's Eye: Women and Work in the Age of Revolution. By Maria R. Miller. (Amherst and Boston: University of Massachusetts Press, 2006. Pp. 302. Cloth, $80.00; Paper, $24.95.)Reviewed by Jeanne BoydstonAs the field of gender and women's history focuses increasingly on matters of theory, it is easy to lose sight of the ongoing importance of the nuts-and-bolts social history that constantly refreshes and renews our knowledge of the daily routines and material contexts of women's lives in the past. Maria R. Miller's The Needle's Eye: Women and Work in the Age of Revolution, a study of women in the sewing trades in late eighteenth- and early nineteenth-century America, reminds us just how meager that stock of information remains, even about so memorialized an activity as colonial women's needlework. To be sure, the first aim of this eloquently written study is simply to reclaim early American needlework from the gauzy myths that have enshrouded it and relocate it firmly and vividly in the workaday world of women's economic and social experience. But Miller is simultaneously engaged in a second, more subtle project: The Needle's Eye is also an argument for the importance of basic social history method not merely as a source of data to test and illustrate theory but as a strategy that can speak meaning as well.Although Miller touches on the unremunerated sewing and quilting that women did within their families, The Needle's Eye is really a study of needlework as a paid craft, and of the women who performed that work as craft artisans during the era of the American Revolution. Indeed, this latter point, that needlewomen belong in the story of the early American craft tradition, is the central theme of the book. Miller contends that an ironic combination of gender practices-the tendency to romanticize women's work and the tendency to masculinize "pride, ambition and competitiveness"-has "made it difficult to imagine women as artisans . . . [or] artisans as female" (4). Thus, historians have been inclined to take notice of women's sewing only within the context of a nostalgic domesticity, suggesting that colonial and early American clothing production occurred chiefly as acts of maternal or wifely devotion-or, as in the (inaccurate) case of Betsy Ross, as peculiarly womanly expressions of patriotism. To the contrary, Miller insists, most sewing took place as a matter of formal economic exchange, organized in needlework shops very much like other craft shops, performed by women who not only depended upon but also trained for, identified with, and took professional pride in their work. In other words, "women were there, too." But Miller doesn't stop there. Her point is that "there" was in fact a different place than we have assumed. She doesn't want to locate women in "craft" as traditionally defined (based on the experiences of males), but rather to use women's craft experiences to redefine the category itself. "Taken as a whole," she writes at the end of her introduction, "this book argues that New England women in the late eighteenth and early nineteenth centuries participated in craftwork in ways that both mirrored and departed from the artisanal culture of their husbands and sons, revealing how the concept of artisanry as it is frequently employed often conceals more than it reveals'1'' (22, italics added). In other words, we need to alter not only our views of women's work but also our (gendered) definition of what constituted a "craft."The organization of The Needle's Eye reflects this contention. The book is divided into three parts, the first and third of which provide summary historical overviews of needlework in the early republic: Part One reviews the production and consumption of clothing in New England in the latter half of the eighteenth century; Part Three summarizes (somewhat too broadly) the economic and organizational transformations of the trades as a result of the growing market economy in the early nineteenth century. …


Moscow city is a dynamically developing city with dense buildings in the centre and a constantly increasing number of vehicles and passenger traffic. By 2014 the main transport problems of the city were the following:
1) High pendulum movements of personal transport during peak hours (region-centre, centre-region)
2) Low efficiency of Surface Urban Passenger Transport (SUPT): high traffic congestion, low priority and delayed movement of the SUPT
3) Chaotic parking in the city centre, sharply reducing the traffic capacity of the streets
4) Low level of safety for both pedestrians and drivers
Solving these and other tasks in the city, earlier we developed several projects to change the traffic organization, but the lack of an integrated approach to design and the introduction of local operational changes did not give the desired result.
In this regard, it was decided to develop a set of measures throughout the city, with a unified approach to design, allowing to consider Moscow street and road network as a single object, thereby to introduce integrally and simultaneously a number of measures to change the traffic organization such as:
1) organisation of separated lanes for public transport;
2) the introduction of one-way traffic;
3) ordering of the parking space;
4) proposals for locally-reconstructive measures (widening of the driveway part, sidewalks, organization of parking bays, security islands;
5) development of cycling infrastructure (cycle lanes and cycle tracks);
6) the organization of parking lots for taxi and cargo transport.
Thus, in 2014, began the work on the creation of the ITMS in Moscow.
In Moscow there are more than 4,000 streets, and the change of traffic organisation in some of them is reflected in the traffic situation of the whole city. And to change the traffic organisation in the whole city during 1 year is simply not possible.


This paper proposes a Swarm Intelligence based Memetic algorithm for Task Allocation and scheduling in distributed systems. The tasks scheduling in distributed systems is known as an NP-complete problem. Hence, many genetic algorithms have been proposed for searching optimal solutions from entire solution space. However, these existing approaches are going to scan the entire solution space without considering the techniques that can reduce the complexity of the optimization. Spending too much time for doing scheduling is considered the main shortcoming of these approaches. Therefore, in this paper memetic algorithm has been used to cope with this shortcoming. With regard to load balancing efficiently, Bee Colony Optimization (BCO) has been applied as local search in the proposed memetic algorithm. Extended experimental results demonstrated that the proposed method outperformed the existing GA-based method in terms of CPU utilization.


AutoCAD is provided with perfect function in drawing,drafting and modeling,but it is deficient in attribute information and picture layer overlapping display.It is not suitable for the civil maps as its unsatisfied charting.The article is aimed at discussing the map-making method of present land-use maps by using AutoCAD and CorelDraw software.This method combines the good drafting function of AutoCAD and the excellent drawing function of CorelDraw,and one of the prominent advantages of this method is to enable people to make very professional map,improve the quality for making maps and reduce the mapping work.


Friction stir processing (FSP) was carried out for AE42 Mg alloy resulting in significant grain refinement and uniform dispersion of fine in situ precipitates. The average grain size was 20 μm for the as‐cast AE42 alloy, which was refined to 1.5 μm after FSP. Tensile testing revealed significantly higher modulus and yield strength for the friction stir processed (FSPed) specimen with some improvement in ductility. The fractured surface of the as‐cast alloy showed ridges, grooves and cracks indicating brittle failure. In contrast, the fractured surface of FSPed specimen showed fine dimples, characteristic of ductile failure. Nano‐indentation was used to analyze the variation of hardness and modulus across the nugget zone of the FSPed specimen. FSPed specimen demonstrated greater strain‐hardening tendency compared to the as‐cast alloy. Enhancing the mechanical properties of Mg alloys can result in substantial cost savings across a number of industries and have wide economic impact.


The teaching method is the basis of the teaching reform of political and moral course,as well as the key of improving the effect,interest of the course.The method and way of improving the teaching effect are discussed from three aspects so as to promote the development of the teaching reform.


Case I: Infective Osteomyelitis of Right Radius of Staphylococcic Origin.L. B., aged 9. Patient came to out-patient department with pain in right forearm, with the history that she was knocked down and fell with her arm under her in the school play-ground on the previous afternoon and had complained of pain in it the same evening. Her mother' is quite definite that when she went to school that day her forearm was quite right. A radiograph (fig. 1), taken on this date, showed practically no change in the bone except, perhaps, a very small area of slight rarefaction at the outer side of the radius at its lower epiphyseal line. The next day, she was admitted to hospital under the care of Mr. Sidney J. Wareham with a temperature of 1000 F., and the forearm was treated with fomentations. The following day, the forearm showed a condition of general cellulitis; under an anesthetic, three long incisions were made down to the bone and pus evacuated. Eight days after this, the temperature had dropped to normal and remained so until the relapse, three and ahalf years later. One month from the onset, another examination (fig. 2) was made, and the lower end of radius seen to be largely disorganized. Here necrosis was seen alongside partially destroyed bone. There was a sharp line of differentiation between the affected and the unaffected portions of the shaft. New bone was being depositQd by the separated periosteum and could be seen along the whole length of inner side of radius. The upper part was also affected, but to a less degree. Beneath the separated periosteum, the cortex of shaft was seen first to become eroded and made irregular and ultimately to MH-7


Introduction: Anti-CD19 chimeric antigen receptor T cells (CART19) and bi-specific anti-CD19/CD3 antibodies (blinatumomab) generate unprecedented complete response rates of 45-90% in relapsing/refractory acute lymphoblastic leukemia (r/r B-ALL). However, a subset of patients treated with these targeted approaches will relapse and a significant portion of these relapses are characterized by the loss of detectable CD19 (about 30% of relapses after blinatumomab and up to 50% after CART19), a clear manifestation of immunoediting. Hence, novel effective strategies are needed in order to be able to treat those patients and ideally prevent antigen-loss. CD123, the interleukin-3 receptor alpha, is involved in hematopoiesis and has been shown to be expressed in several hematologic neoplasms, including acute myeloid leukemia (AML) and more recently also B-ALL. Targeting CD123 with chimeric antigen receptor T cells (CART123) was shown to lead to deep and long-term responses in human primary AML xenografts. The goal of this study was to pre-clinically evaluate the impact of targeting CD123 and CD19 with chimeric antigen receptor T cells for the treatment and prevention of CD19-negative leukemia relapses occurring after CD19-directed therapies. Results: We analyzed the expression of CD123 in 42 r/r B-ALL samples and found that CD123 is highly and homogeneously expressed on the surface of most B-ALL blasts (81.75%, range: 5.1-99.6), making it a promising candidate for targeted therapy in B-ALL. Moreover, CD123 was also found to be expressed in the putative leukemia stem cells (LSC), identified as CD34-pos CD38-neg. Notably, in some Ph+ B-ALL samples we found CD19-ve CD123+ve cells with a BCR-ABL translocation by FISH, suggesting that these cells too are malignant. The expression of CD123 was detected in all (n=6) CD19-negative B-ALL blasts analyzed after relapse from CART19 treatment (Figure 1). These findings indicate that CD123 represents an ideal marker to target CD19-neg ALL blasts occurring after CART19 or blinatumomab. Therefore, we generated anti-CD123 chimeric antigen receptor T cells costimulated with 4-1-BB using a lentiviral vector (CART123). We then evaluated the CART123 anti-B-ALL efficacy both in vitro and in vivo against primary B-ALL and cell line (NALM-6). CART123 showed intense anti-B-ALL ex vivo activity, as defined by specific CD107a degranulation, cytokine production, cytotoxicity and proliferation, not statistically different from that of CART19. In order to test the role of CART123 to target CD19-negative relapses we developed a novel in vivo model, engrafting immunodeficient NSG mice with blasts obtained from a patient relapsing with CD19-ve disease after CART19 treatment. At day 14 mice were randomized to receive CART19, CART123 or control T cells (untransduced, UTD). CART19 and control T cell treated mice had no anti-tumor activity, while CART123 led to complete eradication of the disease and long-term survival. We next developed a murine model to test the hypothesis that a combined approach simultaneously targeting CD123 and CD19 could treat and prevent CD19-negative relapses. NSG mice were injected with a mixture of primary CD19-neg and CD19-pos blasts from the same patient that were labeled with different click beetle luciferases (red or green) in order to be able to track the respective clones in vivo. Mice were then randomized to receive UTD, CART19 or the combination of CART19 and CART123 (same total dose of T cells). As shown in Figure 2, mice treated with UTD had progression of both leukemic clones (CD19-pos and CD19-neg) while CART19 showed rapid progression mostly of the CD19-neg disease (red luciferase); on the contrary only mice treated with the combination of CART123 and CART19 showed rapid clearance of the disease, with improved overall survival (64 days for CART19, not reached for CART19+CART123). As a final strategy, we expressed both CAR19 and CAR123 in the same T cells and showed potent anti-leukemia activity (CD107a degranulation 81.7%). Conclusions: Here we demonstrate that CD123 is expressed in CD19-negative B-ALL relapses occurring after CD19-directed therapies, and that combining CART123 cells with CART19 cells is an effective therapy for the treatment and prevention of antigen-loss relapses in B-ALL murine xenografts. Disclosures Ruella:Novartis: Patents & Royalties, Research Funding. Kenderian:Novartis: Patents & Royalties, Research Funding. Scholler:Novartis: Patents & Royalties. Lacey:Novartis: Patents & Royalties, Research Funding. Melenhorst:Novartis: Patents & Royalties, Research Funding. Hunter:Surface Oncology - SAB: Membership on an entity9s Board of Directors or advisory committees, Research Funding. Porter:Novartis: Patents & Royalties, Research Funding. June:University of Pennsylvania: Patents & Royalties: financial interests due to intellectual property and patents in the field of cell and gene therapy. Conflicts of interest are managed in accordance with University of Pennsylvania policy and oversight; Novartis: Research Funding. Grupp:Novartis: Consultancy, Research Funding. Gill:Novartis: Patents & Royalties, Research Funding.


The threedimensional entity simulation technique is introduced into the design of the radar manufacturing engineering .An example is given to explain it, proving that the application of the threedimensional entity simulation technique in the manufacturing will assist the process planning, making the process program more reasonable, scientific and convenient. 


A complex array of socio-historical, demographic, and organizational factors have combined in recent years to threaten both the current status of and future prospects for the discipline of rural sociology, and for the Rural Sociological Society (RSS). This paper examines the somewhat problematic recent trajectories of the RSS as a professional organization and of rural sociology more generally and notes a degree of disciplinary and organizational inertia that have limited the pursuit of new directions. It also presents a discussion of selected factors that have contributed to these concerns, including both "external" factors that are largely beyond the organizational reach of RSS and "internal" factors that are more directly linked to organizational characteristics and actions. Drawing upon the distinctions between "red ocean" and "blue ocean" strategies outlined by market strategists Kim and Mauborgne, the discussion then shifts to a focus on action alternatives that, if pursued, could help to create an expanded set of opportunities and a brighter future for rural sociology, and for the Rural Sociological Society.


A method for detecting icing one of the detection of objects serving the radar sensor is provided for in a motor vehicle driver assistance system, wherein a control device the operation of the radar sensor controlling the measurement signals given by the radar sensor which indicate the presence of an object evaluates, and on the basis of a measurement signal object data, comprising a distance the object and / or the relative speed of the object to the radar sensor and / or the lateral offset of the object to be a need in the signal compartments of the radar sensor excellent axis determined, wherein detected within the predetermined time interval, the measurement signals, which object data is determined, the distance of ≦ 3, in particular ≦ 2mm, is to the radar sensor, the number of counted measurement signals is compared with a threshold value and the threshold value is reached or exceeded within the icing detection is taken into account.


A series of composite structured Co x Cu 1- x ( x =0.38—0.87) nanowire arrays have been successfully deposited in the same Co 2+ /Cu 2+ =10∶1 solution by applying various depositing potentials. We found that the structures of Co x Cu 1- x composite nanowires regularly changed with increase of Cu content, thus causing regular change of the magnetic properties of CoCu nanowires. With the percent content of Cu increasing, part of Cu and Co form metastable face-centred cubic (fcc) CoCu solid solution which decreases the competition between the crystallographic anisotropy and shape anisotropy and improves the squareness of CoCu nanowires; the remaining part of Cu exists in the nanowires as fcc Cu crystals which destroy the crystallographic anisotropy and increases the pinning of domain walls, thus improves the squareness and coercivity of CoCu nanowires. Comparing Co x Cu 1- x nanowires of different compositions, we found that the nanowires have their maximum of the squareness ( M r / M s ) and coercivity ( H c ) values for Co 75 Cu 25 and Co 60 Cu 40 , respectively. Because of the special composite structures, the values exceed those of single phase CoCu nanowire with the same diameter.


This study investigates effect of different concentrations of ethylenediaminetetraacetic disodium dihydrate (EDTA-Na2: C10H14N2Na2O8.2H2O) and sodium nitrite (NaNO2) admixtures, individually or in synergistic/partial NaNO2 replacement model, on the corrosion of concrete steel-rebar in NaCl and in H2SO4 media. Electrochemical monitoring techniques were employed for 48 steel-reinforced concrete samples immersed in the saline/marine and microbial/industrial simulating test environments for 96 days. These test data were subjected to the analyses of the Normal and the Weibull distribution fitting models, for each of which goodness of their fitting the electrochemical test data were studied using the Kolmogorov–Smirnov test statistics. Analysed results showed that EDTA-Na2 admixture concentrations exhibited better inhibition effectiveness, with relatively good effectiveness in their synergistic admixtures, than their equal-mass NaNO2 counterparts in both corrosive environments. Also, post-electrochemical experiment subjection of the concrete samples to testing and analyses of ASTM C39/C39M-03 and ASTM C267-01 showed that use of the optimally inhibiting 8 g EDTA-Na2 (per 2 × 10–3 m3 concrete) culminates in gross reduction in compressive strength of concretes in both test-media. However, lowered EDTA-Na2 concentrations exhibited better strength improvements with high corrosion inhibition in the test environments. These suggest suitability of EDTA-Na2 as an environmental-friendly NaNO2 alternative for inhibiting steel-rebar corrosion in saline/marine and microbial/industrial environments.


There has been an emergence of various models for long-term time series forecasting. Recent studies have demonstrated that a single linear layer, using Channel Dependent (CD) or Channel Independent (CI) modeling, can even outperform a large number of sophisticated models. However, current research primarily considers CD and CI as two complementary yet mutually exclusive approaches, unable to harness these two extremes simultaneously. And it is also a challenging issue that both CD and CI are static strategies that cannot be determined to be optimal for a specific dataset without extensive experiments. In this paper, we reconsider whether the current CI strategy is the best solution for time series forecasting. First, we propose a simple yet effective strategy called CSC, which stands for $\mathbf{C}$hannel $\mathbf{S}$elf-$\mathbf{C}$lustering strategy, for linear models. Our Channel Self-Clustering (CSC) enhances CI strategy's performance improvements while reducing parameter size, for exmpale by over 10 times on electricity dataset, and significantly cutting training time. Second, we further propose Channel Rearrangement (CR), a method for deep models inspired by the self-clustering. CR attains competitive performance against baselines. Finally, we also discuss whether it is best to forecast the future values using the historical values of the same channel as inputs. We hope our findings and methods could inspire new solutions beyond CD/CI.


The spanwise velocity component of Gortler vortices in a concave surface boundary layer flow was experimentally studied by means of hot-wire anemometer measurements. For this purpose, the wavelength of the Gortler vortices was pre-set to the most amplified wavelength of 12 mm at free-stream velocity of 2.8 m/s, by a series of thin perturbation wires placed near to the concave surface leading edge. The streamwise and spanwise velocity components, respectively, u and w, in the nonlinear region of Gortler vortices were measured using an X-wire probe. The secondary motion induced by the free-stream disturbances in the vortex's head region is observed to be amplified by the appearance of secondary instability. The ∂w/∂y iso-shear contours form alternate positive and negative shear layers across the boundary layer in the upwash region. On the other hand, two pairs of anti-symmetric structures are observed in the ∂w/∂z iso-shear contours near the wall and vortex's head. The w′2¯ contours have two intense regions...


Objective To study the long term results of SCPL-CHP for laryngeal cancer. Methods The long term results of SCPL-CHP were analyzed in 22 patients with squamous cell carcinoma of larynx (stage Ⅲ16 cases, Ⅳ6 cases). The long term results of operation and glottic reconstruction were evaluated by Postoperative Visiting, semi-quantitative Speech Intelligibility analysis and Electroglottograph (EGG). Results The time of decannulation was from 14 days to 32days (mean 22 days). The time of removing feeding tube was from 25 days to 57 days (mean 41 days), and the decannulated rate was 100%.All 22 patients could communicate with their artificial voice. The speech intelligibility of 19 cases was more than 95%, and 3 cases were more than 90%. EGG parameters were checked after 2 years. F0 and NNE were not significantly different, and Jitter and Shimmer significantly reduced. 3-years survival rate was 95.45%. Conclusion SCPL-CHP can apply to patients with advanced laryngeal cancers with the survival rate more than 3 years compared with total larygectomy, and also can be used for retained laryngeal phonation. It is a proper and practical surgical therapy for laryngeal cancer and should be widely applied.


Success can beget success in the field of mHealth if organizations enhance their opportunity to drive successful outcomes by learning from similar projects taking place within the mHealth 'ecosystem.' This section identifies mHealth projects that embody practices of highly scalable and sustainable mHealth programs. The case studies reveal some of the key benefits of mHealth, and provide examples of how to structure successful mHealth initiatives. These case studies also reflect the field's dynamism, as each was implemented within the 12 months prior to the publication of this report.


We present the most recent advances in fast X-ray grating interferometer and their applications.
A dedicated setup for rapid scanning with a single grating and using filtered broadband illumination of an undulator source has been implemented. With this setup tomographic scans can be achieved within minutes. Larger number of samples can be measured and chemical processes can be studied. Improvements in the data processing technique will be presented. We will also describe the new capabilities and applications.


California's water struggles in 2015 highlight the erratic nature of water availability in the state. Supply concerns are expected to worsen in the future as a result of population growth, increased ecological demand, and uncertainty caused by climate change and other factors. In recognition of the pressing need for careful water planning and innovation, some local governments have adopted a requirement that new development be "water neutral." Water neutral policies require new projects to offset their water demand through conservation or new supplies. Water providers praise water neutral policies for increasing water efficiency and sustainability. Water neutral programs facilitate economic development, jobs, and housing, and have the potential to benefit disadvantaged communities. If properly designed, the programs may result in more reliable long-term conservation, and help achieve statewide conservation targets. Water neutral programs also provide incentives for developers to maximize efficiency, encourage investment in technology improvements, and inspire creative thinking about water management. At the same time, economic, practical and political factors can affect the value of water neutral programs. Good design and enforcement are critical to ensuring that water neutral programs achieve real water savings. Although not a good fit for every jurisdiction, regional and local water neutral programs have the potential to play a larger role in California's urban water efficiency portfolio.This article describes the structure of water neutral programs through a survey of existing policies in California and elsewhere, explores the legal framework for adoption of such programs, and identifies key design and policy issues.


The epitopes recognized by pathogenic T cells in systemic autoimmune disease remain poorly defined. Certain MHC class II-bound self peptides from autoimmune MRL/lpr mice are not found in eluates from class II molecules of MHC-identical C3H mice. Eleven of 16 such peptides elicited lymph node cell and spleen cell T cell proliferation in both MRL/lpr (stimulation index = 2.03–5.01) and C3H mice (stimulation index = 2.03–3.75). IL-2 and IFN-γ production were detected, but not IL-4. In contrast to what was seen after immunization, four self peptides induced spleen cell proliferation of T cells from naive MRL/lpr, but not from C3H and C57BL/6.H2k, mice. These peptides were derived from RNA splicing factor SRp20, histone H2A, β2-microglobulin, and MHC class II I-Akβ. The first three peptides were isolated from I-Ek molecules and the last peptide was bound to I-Ak. T cell responses, evident as early as 1 mo of age, depended on MHC class II binding motifs and were inhibited by anti-MHC class II Abs. Thus, although immunization can evoke peripheral self-reactive T cells in normal mice, the presence in MRL/lpr mice of spontaneous T cells reactive to certain MHC-bound self peptides suggests that these T cells actively participate in systemic autoimmunity. Peptides eluted from self MHC class II molecules may yield important clues to T cell epitopes in systemic autoimmunity.


There is provided a method of manufacturing an electronic element for forming the electronic element including one or more wiring layers and an organic insulating layer stacked on a substrate. The method includes a wiring layer formation step of forming the wiring layer on the substrate; an organic insulating layer formation step of forming an organic insulating layer on the wiring layer; and an irradiation step of irradiating a short-circuit portion of the wiring layer through the organic insulating layer with a laser beam having a wavelength transmissive through the organic insulating layer.


The ten essays in this special issue of Science in Context address the formation of scientific personae from the sixteenth through the twentieth centuries in Europe and North America. The departure point for the collection was a year-long (1998–99) research project (including a final conference) on "The Scientific Persona" organized at the Max Planck Institute for the History of Science, Berlin. This project was in turn inspired by a seminal essay by the French anthropologist Marcel Mauss on the historical and cultural development of the category of personhood, from the tribal personnage to the modern moi (Mauss 1938). Because the application of Mauss' term "persona" to the history of science is somewhat novel, and also unforeseen by Mauss himself, we must first explain what is meant by the term in these essays, and why we believe Mauss' historicization of personhood, somewhat modified, to be illuminating for the history of science. Mauss' essay, "Une catégorie de l'esprit humain: La notion de personne, celle de 'moi'. Un plan de travail," originally delivered in 1938 as the Huxley Memorial Lecture in London, reveals its program already in its title: it was meant to present British colleagues with an example of the "French School of Sociology," more particularly "the social history of the categories of the human mind" (Mauss 1938, 263). Mauss wished to display the possibilities of this historicized neo-Kantianism by means of a prototypical Kantian example, the self, das Ich (Trendelenberg 1908), assumed by modern philosophers to be an innate mental category. To this end, he traced a long developmental arc from the rites of personnage in ancient Greece, Rome, and India (which he believed to be to some degree paralleled by extant practices among the indigenous peoples of North America and Australia), through the institutions of Roman law and medieval Christian theology that forged the persona, to the eighteenth-century emergence in a few European cultures of the moi or self. Mauss' three phases might roughly (the word is used advisedly – he insisted upon the crudeness of his first approximations) be characterized as follows. In societies organized around the personnage, or "role," identities and the names that designate them are recycled from generation to generation, so that ancestors are endlessly reincarnated and the social structure of the clan appears static. These reincarnations are often reinforced by inherited names, ranks, rights, and functions, and symbolized by ceremonies involving masks to map the individual face into the ancestral role. The Latin word persona in fact means "mask," and Mauss located the critical transitional phase between personnage and moi in Greek and Latin moral philosophy and law, later Science in Context 16(1/2), 1–8 (2003). Copyright © Cambridge University Press DOI: 10.1017/S026988970300067X Printed in the United Kingdom


questionable indications for abdominoperineal procedures in patients with tumors not involving the sphincters; and (iii) conflicting data in publications addressing the same cohorts of patients. The first point of discussion refers to the authors' breakdown of the series into groups based on their perception of what type of abdominoperineal procedure might have been performed. The authors stated that the type of procedure [Extralevator abdominoperineal excision (ELAPE) or nonELAPE] was documented only in some records, whereas in a large number of the records, the authors simply guessed what type of procedure might have been carried out. Moreover, the authors could not decide what type of abdominoperineal procedure was performed in half of the records. Hence, the readers can hardly rely on the retrospective allocation of cases to one procedure or another. Such recall bias is likely to have led to unwarranted conclusions because of noncomparability of the study arms. The second concern refers to the inclusion in the analysis of patients with a rectal cancer located more than 4 cm from the anal verge. Abdominoperineal procedures should be indicated for patients with a suspected involvement of the sphincter muscles. In fact, procedures such as intersphincteric resections may be considered as an option in case of absence of sphincter involvement. Moreover, Prytz et al failed to provide the readers with the T-stage stratification of the subgroup of patients with cancer located less than 4 cm from the anal verge to prove comparability. The third category for discussion involves a back-toback comparison of publications. In the recent article, ELAPE resulted in a significantly increased 3-year local recurrence rate as compared with non-ELAPE with intraoperative perforation as an important risk factor for local recurrence. In the earlier paper, ELAPE did not result in fewer intraoperative perforations or involved circumferential resection margins as compared with non-ELAPE. The above mentioned statements seem not only incongruent with common practice and the literature, but also not supported by the analysis of heterogeneous and noncomparable patient subgroups. Figure 1 in the article by Prytz et al compared 58 patients and 385 patients with cancer located less than 4 cm from the anal verge having undergone non-ELAPE and ELAPE, respectively; such subgroups are not comparable for size (P < 0.0001). Table 1 shows a mean tumor height of 6.0 and 3.0 cm for non-ELAPE and ELAPE, respectively (P < 0.0001). Table 1 of the previous publication showed 17 patients (8%) versus 176 patients (34%) with tumor location less than 2 cm from the anal verge in the nonELAPE and ELAPE arms, respectively (P value not reported). Furthermore, the long-course radiation ratio (non-ELAPE 24% vs ELAPE 36%, P< 0.0001) represents an additional bias. In conclusion, the readers should be less impressed with the size of the series and more attentive to the quality of the methodology.


This work shows the application of one of the techniques of bioengineering, the perceptron network in the detection of system failures, and also allows the use of the perceptron network technique in choosing the location of the best sensor to be used in the dynamic system. The application of the perceptron network was adopted because it is considered the best binary linear classifier. This work is considered multidisciplinary and difficult to develop. The final result demonstrates a severe application of pre-processing and processing, until the classification and grouping of signals in the two phases of the work. Through the results found, this work can be considered successful and can be applied in several areas of engineering for structural analysis.


Aczel-Alsina t-norm belongs to the family of strict t-norms that are the most applied fuzzy operators in various fuzzy modelling problems. In this paper, we study a linear optimization problem where the feasible region is formed as a system of fuzzy relational equations (FRE) defined by the Aczel-Alsina t-norm. Since the feasible solutions set of FREs is non-convex and the finding of all minimal solutions is an NP-hard problem, conventional methods may not be directly employed. The resolution of the feasible region is completely investigated. Based on some theoretical properties of the problem, an algorithm is presented to find all the optimal solutions, and finally an example is described to illustrate this algorithm.


Linkage studies have identified a large (>60‐Mb) region on chromosome 10q that segregates with Alzheimer Disease (AD). Within the region, the gene for insulin degrading enzyme (IDE) represents a notable biological candidate given that it degrades amyloid β‐protein (one of the major constituents of senile plaques) and the intracellular amyloid precursor protein (APP) domain released by γ‐secretase processing. We have used a single nucleotide polymorphism (SNP) genetic association strategy to investigate AD in relation to a 480‐kb region encompassing IDE. A 276‐kb linkage disequilibrium block was revealed that spans three genes (IDE, KNSL1, and HHEX). Assessing this block in several independent sets of case‐control materials (early‐ and late‐onset AD) and focusing also upon quantitative measures that are pertinent to AD diagnosis and severity (MMSE scores, microtubule‐associated protein Tau [MAPT] levels in CSF, degree of brain pathology, and age‐at‐onset) produced extensive evidence for significant AD association. Signals (p‐values ranging from 0.05 to <1×10−9) were generally stronger when examining haplotypes rather than individual SNPs, and quantitative trait tests most uniformly revealed the detected associations. Consistent risk alleles and haplotypes were apparent across the study, with effects in some cases as large as that of the ϵ4 allele of APOE. A subsequent mutation screen of exons in all three suspect genes provided no evidence for common causative mutations. These results provide substantial evidence that genetic variation within or extremely close to IDE impacts both disease risk and traits related to the severity of AD. Hum Mutat 22:363–371, 2003. © 2003 Wiley‐Liss, Inc.


To cope up with the competitive and highly regulated banking sector, every bank is trying to put their focus on satisfying its customers. As a result consumers' need is required to be found out. This research focuses on the issues to find out consumers' perception on general banking activities of a commercial bank. The paper provides an understanding of different factors that affect consumer perception on general activities of a bank. Here 3 factors are generated with the help of factor analysis. This sort of research is also helpful to find out consumer's perception in different industries and organizations. Keyword: Factor analysis, General banking activities, Commercial banks


Nineteen of twenty dogs undergoing experimental esophageal transection with mechanical suturing were followed up over 1 to 120 days by means of light and electron microscopy examinations to evaluate changes in suture line. Histology showed few reactions to the metallic clips, the absence of new vessel formation with early healing from the 4th day, development of collagen fascicles after 1 week and consolidation after 2 weeks with reparation by the end of 1st month. Stability of healing process was apparent between 3 and 4 months, without evidence of stenosis due to scar tissue.


A transient Ne-like x-ray laser at 19.6 nm (J=0→1, 3p→3s) is numerically investigated using a hydrodynamic code for a 100 μm thick Ge planar target irradiated by a nanosecond prepulse followed by a subpicosecond or a picosecond main optical laser pulse. Simulations are performed for different main pulse lengths of 50 fs, 500 fs, 5 ps, and 50 ps but with fixed pulse energy. For a drive pulse even as short as 500 fs, the x-ray laser gain still shows quasisteady state behaviors. A real transient nature can only be seen when the x-ray laser is driven by a laser pulse with a duration as short as tens of femtoseconds.


CONVENTIONAL WISDOM suggests that turnover among city managers is frequent, that the average tenure in a given managerial post is brief by most professional standards, and that the odds of remaining for more than a decade in a single community are infi nitesimally small. Some city managers compare their own tenure and turnover prospects with those of managers in professional baseball, where careers are tenuous and longevity is rare. Scholars have examined city manager turnover, usually in attempts to explain the causes of turnover, its consequences, or the relationship between tenure and other variables. Rarely have systematic studies focused primarily on identifying more precisely the typical time interval between the appointment and departure of local government managers. This research note focuses not on the reasons for managerial turnover—i.e., the "push" factors that force a manager from the current post or cause the manager to want to leave or the "pull" factors that attract the manager to a new opportunity (Kammerer et al. 1962; Feiock and Stream 2002; Green 1987; Barber 1988; DeHoog and Whitaker 1990)—or on characteristics of municipal structure associated with managerial longevity (Whitaker and DeHoog 1991; Booth 1968; Kammerer et al. 1962). Nor is the focus on the relationships between community or attitudinal characteristics and tenure (Feiock et al. 2001; DeSantis, Glass, and Newell 1992) or the consequences of frequent turnover (Clingermayer and Feiock 1997; 2001). Instead, the focus is on the common method of gauging average managerial tenure, the potential for misinterpretation and misuse of the "average tenure" statistic derived by this method, and the ramifi cations of such misinterpretation or misuse.


The authors report the results of measurements of the cosmic background radiation temperature at wavelengths of 9.1 and 3.3 mm. The 9.1 mm result, T{sub CBR} = 2.87 {+-} 0.21 K, is in good agreement with previous results and those obtained at longer wavelengths during the same experiment. The 3.3 mm result, T{sub CBR} = 2.4 {+-} 1.0 K, is consistent with previous measurements, but has a large error due to uncertainty in the atmospheric correction.


An object of the present invention is to provide a system and method for high-speed central point correction of tape drives that use the flangeless tape path. A servo system according to one embodiment, at least one servo sensor for sensing the lateral position of the magnetic head with respect to at least one predetermined servo track of the longitudinal tape, transversely to the longitudinal tape to include a fine actuator configured to translate the magnetic head, a coarse actuator configured to move the fine actuator in the transverse direction to the longitudinal tape parallel, and the servo control device. The servo control device for correcting a tape drive configured to perform various operations that can be used to estimate the center point of the lateral position variations of the flangeless tape path. Additional systems and methods are also provided. .FIELD 7


This study is about the enterprising incubation in universities that look for opinions from authorities, professors, and students in the Accounting Department in regards to the importance and necessity of the development of students who have entrepreneurial potential in the Accounting Department, helping the student with an alternative action that allows them to: canalize the most effective incaution between the university and the private sector, while at the same time to conceive it as one of the strategies that allows us to accomplish the institutional vision and the compromise with the social and economical development of the country. Among the exposed aspects considered are: the conceptualization of the company incubation, its evolution and level of development, characteristics and implications of the incubation process, moreover a revision of a country context and the social, economic, and academic conditions of the private sector program. We concluded that there are not enough universities that have an incubation program for entrepreneurial students, and the few that exist have to improve on their programs, Brazil and Mexico are the few countries that have these programs more so than any other country in desarrothe Latin American region. Entrepreneurial incubation is still a theme that is developing and it has to overcome challenges and limitations especially when it comes to lack of resources and insufficient.


The total synthesis of natural (-)-ptaquilosin (2) the aglycon of a potent carcinogen ptaquiloside (1) from bracken fern and its (+)-enantiomer (2) has been achieved starting with (+)-dimenthyl (1R,2R)-cyclopentane-1,2-dicarboxylate. The synthesis proceeds in 20 steps (2.9% overall yield). As the DNA cleaving activities, dienone 4 prepared from natural(-) ptaquilosin (2) was shown to be more efficient than dienone 4 derived from (+) ptaquilosin(2)


This paper aims at the recollection of theoretical elements which would enable for an adequate definition of citizen's security at the level of poor residential groups resulting from state policies. Such purpose is faced from a new interdisciplinary and systemic viewpoint which tries to develop a socio-spatial perspective aiming at overcoming the reductions which characterize the classical studies on the topic which give emphasis unilaterally either to physical or spatial variables. The community is defined, in a preliminary way, as a self -referent system which starting from is own communicative selections is able to face the problem of insecurity in residential areas. Some socio-physical conditioners which help to place and understand in a more integral way the dynamics and complexity of this phenomena, are here stated.


Interventions for medication adherence should be multifaceted, speakers told attendees at the recent Pharmacy and Technology Conference in San Diego sponsored by the National Association of Chain Drug Stores.


The invention discloses a system, a device and a method for multi-network integration. The system comprises an application gateway server and a unified account management server, wherein the application gateway server is used for resolving a domain name in an access request sent from a client to an application system, acquiring an authentication notification based on the acquired resolved address, and establishing a communication connection between the client and the application system based on the notification; the unified account management server is used for performing authentication on anaccount corresponding to the resolved address, and notifying the application gateway server if the authentication is passed. The method comprises the following steps of: resolving the domain name in the access request sent from the client to the application system, acquiring the authentication notification based on the acquired resolved address, and establishing the communication connection between the client and the application system. The system, the device and the method for the multi-network integration can overcome the defects of incapability of uniformly accessing and managing multiple networks, complex account application procedure, poor safety, low efficiency and the like to realize uniform access and management of the multiple networks, simplify the account application procedure,and improve the safety and the efficiency.


his response to my essay, Yoel Finkelman disagrees with my interpretation of the Rav's views on religion and public life, as well as with my description of the history of the United States with regard to this issue. I will briefly address each of these contested areas. Let me begin with the Rav. Finkelman's central complaint appears to be that my essay focuses on the Rav's written instructions in "On Interfaith Relationships," rather than the Rav's other writings. Finkelman refers to "On Interfaith Relationships" as a "policy statement," but of course, it is more than policy: it is pesak. These guidelines, as I noted in my essay, were printed as an open letter in the Rabbinical Council of America Record. By expressing his views in that particular medium, the Rav, as the posek par excellence of the Rabbinical Council of America, set out in precise terms, to Jewish Orthodoxy and to the world, the nature, goals and limits of the RCA's interfaith dialogue with the Catholic Church. It is surprising, then, that Finkelman in effect questions whether "On Interfaith Relations" is the best source for defining the Rav's position. He is essentially asking why, in seeking practical instruction as to how American Orthodoxy should engage the Christian community, I look first and foremost to the Rav's practical instruction as to how American Orthodoxy should engage the Christian community. Further, the Rav's stated opinion in "On Interfaith Relationships" is not contradicted by the other writings of the Rav that Finkelman cites in his reply. Finkelman's central citations are taken from The Lonely Man of Faith, which for him is the "essay by the Rav containing the most extensive reflections on the relationship between religion and public


Long-distance education has developed into internet stage from correspondence and broadcast television. It will play an important role for study in lifetime. Combined with the establishment of teaching station at Baotou Steel , the function and development are discussed from the aspects of degree, post training and continuous education.


SUMMARY The paper examines the main changes in the media system in a transitional society (in this case Belorus). Media autonomisation by the State is considered a mainstream process in these changes. The process is analysed through theoretical models based on understanding media as guarantor of the development of civil society, public space and participatory democracy. This analysis includes political (media position in the political structure and attitudes of different political elites to the media), legal (constitutional, law and 'lower legislative' levels) and economic (ownership and founding partnership) aspects of changes in the media system, based on the results of various surveys conducted in 1992–1994.


Spectroscopic observations made by the Extreme Ultraviolet Variability Experiment (EVE) on board the Solar Dynamics Observatory (SDO) during the 2012 March 7 X5.4-class flare (SOL2012-03-07T00:07) are analyzed for signatures of the non-Maxwellian κ-distributions. Observed spectra were averaged over 1 minute to increase photon statistics in weaker lines and the pre-flare spectrum was subtracted. Synthetic line intensities for the κ-distributions are calculated using the KAPPA database. We find strong departures (κ ≲ 2) during the early and impulsive phases of the flare, with subsequent thermalization of the flare plasma during the gradual phase. If the temperatures are diagnosed from a single line ratio, the results are strongly dependent on the value of κ. For κ = 2, we find temperatures about a factor of two higher than the commonly used Maxwellian ones. The non-Maxwellian effects could also cause the temperatures diagnosed from line ratios and from the ratio of GOES X-ray channels to be different. Multithermal analysis reveals the plasma to be strongly multithermal at all times with flat DEMs. For lower κ, the are shifted toward higher temperatures. The only parameter that is nearly independent of κ is electron density, where we find log ≈ 11.5 almost independently of time. We conclude that the non-Maxwellian effects are important and should be taken into account when analyzing solar flare observations, including spectroscopic and imaging ones.


BMSCs have the potential of multipotent differentiation. This study aimed to investigate the interaction between MACC1-AS1 and miR-145-5P in BMSCs and their effect on chemotherapy resistance in colorectal cancer (CRC). BMSCs extracted from mouse marrow were transfected with MACC1-AS1
 mimic, or MACC1-AS1 NC (control group). CRC cells were treated wtih gemcitabine and then co-cultured with BMSCs to measure cell viability and invasiveness by MTT and Transwell assay, along with analysis of the expression of MACC1, miR-145-5P, HGF, C-met, P-gp, and MRP. Successful isolation
 of BMSCs was confirmed by flow cytometry with positive expression of CD44, CD105, and CD90 (purity > 95%). Functionally, overexpression of MACC1-AS1 in BMSCs increased CRC cell viability and invasion, attenuated the inhibitory effect of gemcitabine (p < 0.05). Up-regulation of
 MACC1-AS1 (9.23±1.21) as demonstrated by RT-qPCR, resulted in a decline of miR-145-5P expression (4.23±1.22) in CRC cells (p < 0.05). In addition, overexpression of MACC1-AS1 increased the expression of HGF, C-met, and multidrug resistance-associated proteins (P-gp,
 and MRP). In conclusion, overexpression of MACC1-AS1 in BMSCs inhibits miR-145-5P expression to promote colorectal cancer cell progression possibly via activating HGF/C-met pathway and inducing resistance to chemotherapy.


Three-dimensional (3-D) radar imaging has been widely used in target scattering diagnosis, modeling and target identification. In this paper, 3-D imaging algorithm for targets with micro-motion based on high resolution range profile (HRRP) sequence is presented. Aiming at the difficulty of getting look angle parameters of the radar directly and considering the precession feature of targets with micro-motions, a way of turning precession parameters into angle parameters indirectly is proposed. Meanwhile, for the scattering centers association, two methods are discussed and compared. Finally, performance analysis under the influence of related factors is also covered and the parameter constraints are given, and thus provide a reference for the design of 3-D radar imaging system. Simulation results are presented in the end, which prove the efficiency of the proposed method.


Despite the apparent ubiquity of pyrophosphate: fructose 6-phosphate 1phosphotransferase (PFP) in plants no clear physiological role has emerged for it. Transgenic plants with upor down-regulated PFP activity showed only small changes in the levels of metabolites directly associated with it but no significant, stable phenotypic changes. In sugarcane PFP activity is inversely correlated to sucrose content in maturing internodal tissues, suggesting a more prominent role for it in carbohydrate partitioning in these tissues. In this review I will therefore first give an overview of the molecular, kinetic and regulatory characteristics of plant PFPs, which could help elucidate its apparent role in sucrose metabolism and then I will discuss these potential roles with specific reference to the sucrose accumulation phenotype in sugarcane. Finally, I present two hypotheses that might explain PFP's role in sucrose accumulation in sugarcane. INTRODUCTION Sugar metabolism has been studied extensively in sugarcane in an attempt to elucidate the molecular basis of the sucrose storing phenotype (Batta et al. 1995, Moore 1995, Botha et al. 1996, Moore and Maretzki 1996, Lingle 1999, Moore 2005, Rae et al. 2005 and the references in these). In doing so, many of the enzyme reactions involved in sucrose metabolism in sugarcane sink tissues (Figure 1) have been characterised. These include sucrose phosphate synthase (SPS, Grof et al. 1998, Botha and Black 2000), sucrose phosphatase (Gutierrez-Miceli et al. 2002), sucrose synthase (SuSy, Lingle and ∗ To be submitted to Plant Physiology and Biochemistry


The main aim of this paper, which is the sequel to [Ka], is to prove the existence of curves C of genus 2 admitting morphisms to two given elliptic curves E and E ′. More precisely, we are interested in the following problem. Question. Given two elliptic curves E and E ′ over an algebraically closed field K and an integer N ≥ 2, does there exist a curve C of genus 2 which admits two morphisms f : C → E, f ′ : C → E ′, of degree N such that the induced maps f ∗ and f ′ ∗ on the associated Jacobian varieties fit into an exact sequence


college students and building a socialist harmonious society is the backbone to strengthen religious education helps students to correctly understand the phenomenon of religious culture,the correct analysis of the religious problem,a correct attitude toward religion.In view of the current ideological and practical,it is necessary to give full play to the "Two Courses" as the main channel,the main front,innovative forms and methods of education,active in in-depth and meticulous ideological and political work,strengthen science education,the Marxist concept of religious education and the party's Religious education policy,as well as religious education.


The permittivity and dielectric loss tangent of single-crystal quartz, cross-linked polystyrene (Rexolite), and polytetrafluoroethylene (Teflon) were measured at microwave frequencies and at temperatures of 77 K and 300 K using a dielectric resonator technique. Application of high-temperature superconducting (HTS) films as the endplates of the dielectric resonator made it possible to determine dielectric loss tangents of about 7/spl times/10/sup 6/ at 77 K. Two permittivity tensor components for uniaxially anisotropic crystalline quartz were measured. Although the permittivities at 77 K changed very little from their room temperature values at 300 K, large changes in dielectric losses were observed. The decreased loss characteristics of these microelectronic substrates can markedly improve the performance of many microwave devices at cryogenic temperatures.<<ETX>>


This thesis illustrates the structure and characteristics of Macpherson Suspension,and makes analysis on the impact on the stability and comfort which caused by the accurate relationship between the oriented links with steering characteristics.In addition,it explains the application of UG Motion Module of the oriented links and the steering characteristics.


We measured the wavelength shift and wavelength chirping of a high- power quasi-cw twodimensional (2D) laser diode (LD) array by using the polychromator we constructed. The absorption efficiency calculated was compared with experimental values of a Nd: YAG amplification module pumped by using a quasi-cw 2D LD array. We propose that the optimum 2D LD array pumping systems should use a feedback control either on the time-resolved spectrum of LD or on the transmitted power during pulsed operation.


Modern medicine has failed to reduce or prevent the incidences of cardio metabolic diseases such as obesity, metabolic syndrome and type-2 diabetes. Integrated approach to health care seems to be the future for effective management of these chronic diseases [1-5]. Obesity, excess weight and type-2 diabetes have reached an epidemic status, pose a global health crisis and as such contribute significantly to healthcare burden. According to various estimates, excess weight and obesity are the driving force for the observed epidemics of type-2 diabetes. The Non Communicable Disease (NCD) Risk Factor Collaboration Group, in their article in Lancet (April 2016) concluded that, "if the post-200 trends continue in the incidence and rise of type-2 diabetes, the probability of meeting the global target of halting or reducing the rise in the prevalence of type-2 diabetes by 2025, to the 2020 level worldwide is lower than one percent". According to the Institute for Health Matrices and Evaluation (IHME), currently 2.1 billion people (nearly 30% of the global population) are either obese or overweight. Since 1980, obesity has increased worldwide by two fold and diabetes by four fold, In this mini review, we will discuss some recent strategies and interventions for management of these chronic metabolic diseases.


Principal coordinates analysis (PCO) is a technique proposed by Gower (1966) to analyse a multivariate data matrix, representing the distances between the rows (the objects) by distances between object points in a low-dimensional space, through an approximation using scalar products. For Euclidean distances, this paper generalizes the technique to a nonlinear variety, i.e. nonlinear transformations of the variables (the columns of the data matrix) are incorporated. These transformations are optimal according to the scalar product criterion that is minimized. This criterion can be re-expressed in terms of the eigenvalues of the correlation matrix for the variables: nonlinear principal coordinates analysis then minimizes the sum of squares of a pre-chosen number of small eigenvalues. The optimal nonlinear transformations are obtained by using iterative majorization.


The electronic band structures of two-dimensional materials are significantly different from those of their bulk counterparts due to quantum confinement and strong modifications of electronic screening. An accurate determination of electronic states is a prerequisite to design electronic or optoelectronic applications of two-dimensional materials; however, most of the theoretical methods we have available to compute band gaps are either inaccurate, computationally expensive, or only applicable to bulk systems. Here we show that reliable band structures of nanostructured systems can now be efficiently calculated using density-functional theory with the local modified Becke-Johnson exchange-correlation functional that we recently proposed. After reoptimizing the parameters of this functional specifically for two-dimensional materials, we show, for a test set of almost 300 systems, that the obtained band gaps are of comparable quality as those obtained using the best hybrid functionals but at a very reduced computational cost. These results open the way for accurate, high-throughput studies of band structures of two-dimensional materials and for the study of van der Waals heterostructures with large unit cells.


The temperature field and the thermal error for the spindle of machining center have been measured by five-spot method.A linear regression model between the temperature changes and the thermal error for the spindle has been built up by partial least-squares regression method.By computation and analysis,this model is provided with good forecast ability and enough precision.


Two-phase thermal management technologies are promising cooling solutions for the high performance electronics in the next generation military and commercial vehicles. However, vibrations (∼ 10Grms in commercial automobile engines and transmissions) and shocks (30G to 1,200G in military combat vehicles, caused by gun firing, ballistic launch and abrupt maneuvering) present a severe challenge to any capillary-driven (i.e., passive) two-phase devices. A low-cost, vibration/shock-tolerant Capillary Two-Phase Loop (CTPL) technology was developed as a cooling alternative for the future military vehicles. Unlike the traditional two-phase cooling loops such as Loop Heat Pipes (LHP) and Capillary Pumped Loops (CPL), the CTPL offers the following advantages: (1) lower manufacturing cost by sintering the evaporator wick in-situ; (2) improved tolerance to vibrations and shocks due to the improved mechanical strengths of the in-situ sintered wick; (3) improved heat flux performance because of the non-inverted meniscus wick. Small-scale proof-to-concept CTPL prototypes were successfully tested up to 120W of heat input and under multiple, consecutive shocks of up to 6.6G.Copyright © 2008 by ASME


In most computer graphics today, the goal is to make visualizations that "look good and natural" rather than to make correct simulations of reality1,2. However, when using Virtual Reality (VR) as a colour design tool, light and colour must appear in the VR-environment as in reality. In this project, the aim is to simulate perceptual light and colour phenomena more correctly. Real rooms are compared to digital models. In the digital models, some contrast phenomena did not appear. The poster presents a work in progress, were we elaborate on rendering solutions. The first step was to filter digital renderings with the Automatic Color Equalization (ACE) algorithm. By filtering rendered textures of each multicoloured wall, the virtual reality model improved in colour appearance. However, further adjustments of ACE are needed in order to include 3D colour phenomena.


It is my great pleasure to welcome you to the 15th ACM SIGPLAN International Conference on Functional Programming -- ICFP'10. This conference features original papers on the art and science of functional programming. Submissions are invited on all topics from principles to practice, from foundations to features, from abstraction to application. The scope includes all languages that encourage functional programming, including both purely applicative and imperative languages, as well as languages with objects or concurrency.

This year, the Call for Papers attracted 99 submissions, comprised of 92 full submissions and 7 experience reports. From these, the Program Committee selected 30 full papers and 3 experience reports. Full papers were evaluated according to their relevance, correctness, significance, originality, and clarity. Full papers include a special form of research paper, called Functional Pearls, which are not required to report original research, but must be concise, instructive, and entertaining. They are strictly limited to twelve pages. ICFP also includes experience reports. These reports provide evidence that functional programming really works or describe obstacles that have kept it from working. Experience reports are labeled in their titles and are limited to six pages.

Each submission was reviewed by at least three Program Committee members. PC members were encouraged to solicit external reviews, but were required to read the papers themselves and form their own opinions. Reviews included comments from 125 external reviewers, and were made available to the authors for response before the PC meeting. Papers were selected during a physical meeting on June 3-4, 2010, held at Microsoft Research Cambridge. All PC members attended the meeting. In addition to selecting the program, the PC also chose to invite talks by Mike Gordon, Matthias Felleisen and Guy Blelloch. There were three submissions by PC members, two of which were accepted. These submissions were discussed after all other decisions had been made and were evaluated at a higher standard.


Comment spam is a fact of life if you have a blog or forum. Tools like Akismet and CAPTCHA help prevent spam in applications like WordPress or phpBB. However, they are not devoid of shortcomings. CAPTCHAs are getting easier to solve by automated adversaries like bots and pose usability issues. Akismet strives to detect spam, but can't do much to reduce it. This paper presents the kaPoW plugin and reputation service that can complement existing antispam tools. kaPoW creates disincentives for sending spam by slowing down spammers. It uses a web-based proof-of-work approach wherein a client is given a computational puzzle to solve before accessing a service (e.g. comment posting). The idea is to set puzzle difficulties based on a client's reputation, thereby, issuing "harder" puzzles to spammers. The more time spammers solve puzzles, the less time they have to send spam. Unlike CAPTCHAs, kaPoW requires no additional user interaction since all the puzzles are issued and solved in software. kaPoW can be used by any web application that supports an extension framework (e.g. plugins) and is concerned about spam.


This research has objectives including: (1) knowing the implementation of instilling entrepreneurial values in the creative economy division, (2) discussing inhibiting factors and supporting factors for the cultivation of entrepreneurial values in the creative economy division, (3) solutions in overcoming inhibiting factors. The research approach used is a qualitative approach with data collection through interviews, observation, documentation. Data analysis uses three stages, namely data reduction, data presentation, conclusions. The results of the study explained that: (1) the creative economy division was given the cultivation of entrepreneurial values; the value of cooperation; responsibility; creativity with the pre-order system activities at STAI Al-Hamidiyah Jakarta, (2) inhibiting factors in instilling entrepreneurial values; communication and cooperation between members of the creative economy division are poorly established; The means of entrepreneurship at STAI Al-Hamidiyah Jakarta are inadequate, then supporting factors include; DEMA supervisors and lecturers support the pre-order system in the creative economy division; BPH contributes to the implementation of the pre-order system in the creative economy division, (3) The solution in overcoming inhibiting factors is to consistently hold meetings to evaluate pre-order and creative activities in promoting the products of the Creative Economy Division to be visible to the campus and provided support through means in entrepreneurship. The conclusion is that the entrepreneurial values in the creative economy division that have been instilled consist of three values, namely the value of cooperation between division members in managing products, the value of responsibility in the duties of their respective members, and the value of creativity in managing selling products.
Keywords: Entrepreneurial Values, Creative Economy


Objective To explore clinical outcomes of different plastic surgeries for children with cleft lip nasal deformity.Methods A tatal of 133 patients of unilateral cleft lip with secondary nasal deformity registered to our hospital between January 1994 and January 2011 were recruited in this study.These patients were allocated to receive self-designed repair and overall rotation reduction of the alar cartilage ring (group A,n=36),open plastic surgery for cleft lip nasal deformity (group B,n=47),neonatal cleft lip repair (group C,n=28),or early cleft lip rhinoplasty (group D,n=22).The clinical efficacy of different plastic surgeries were compared and analyzed.Results The patients were followed up for 24 months after surgery.Excellent outcomes were achieved in 94.44%,97.87%,96.43%,and 95.45% of the patients in groups A,B,C,D,respectively.There was no significant difference in the rate of excellent outcomes between groups (P> 0.05).In all 4 groups,there was obvious difference in the distances from midline to the lateral crus of alar cartilage and to the longitudinal axis of nostril between cleft and healthy sides before operation (P<0.05),which was not found after plastic surgeries (P>0.05).There was no significant difference in postoperative complications among the 4 groups during the 2-year follow-up (P>0.05).Conclusion Repair of alar cartilage ring complex may improve the appearance of nasal tip,nasal alar and nasal floor.Open plastic surgery for cleft lip with secondary nasal deformity is by far the most thorough alar cartilage plastic surgery.Neonatal cleft lip repair is safe and effective.Early repair of cleft lip rhinoplasty is promising for better nasal morphogenesis.

Key words:
Nose deformities, acquired ;  Cleft lip ;  Surgery, plastic ;  Repair of alar cartilage ring;  Open plastic surgery of cleft lip with secondary nasal deformity


The fluorination of [MeAlN(2,6-i-Pr2C6H3)]3 1 using 1 and 2 eq., respectively, trimethyltin fluoride leads to the monoand difluoro compounds, [FAl(MeAl)2(N(2,6-i-Pr2C6H3))3] 2THF 2 and [(FAl)2MeAl(N(2,6-i-Pr2C6H3))3] 3THF 3, where each methyl group can be selectively exchanged for terminal fluorine atoms (Al–F). The reaction of 1 and 3 eq. of trimethyltin fluoride leads to the trifluoro compound [FAlN(2,6-i-Pr2C6H3)]3 3THF 4 and [Me2SnN(2,6-i-Pr2C6H3)]2 5 as a by-product. The core of compound 5 consists of a tin–nitrogen fourmembered Sn2N2 ring. # 2002 Elsevier Science B.V. All rights reserved.


RL Wasserman, AR Hague, DM Pence. J Allergy Clin Immunol Pract. 2019;7(2):418–426.e4

This retrospective record review reports observations on the treatment of 270 patients with peanut allergy with peanut oral immunotherapy (POIT).

The study included 270 patients between the ages of 4 and 18 years who received POIT in a single practice between 2009 and 2017. A total of 96.7% of patients had a history of an immunoglobulin E–mediated reaction, 70.7% had experienced anaphylaxis, 26% had a peanut-specific immunoglobulin E (PSIgE) concentration of >100 kU/mL, and 9.6% had a positive peanut challenge result within 2 years of inception of POIT. No patient was excluded on …


The fact that we are the unconscious prisoners of language and metaphors has wide-ranging implications for organizations and their management. Metaphors have often been considered as just a decorative too! to garnish language, but advancements in cognitive science have revealed that they are, in fact, an essential component of our thinking process as they influence the way we think, see, and act. In this paper, the authors explore the nature and characteristics of metaphors and highlight some of the classic metaphors that underlie approaches to management. While the classic metaphors have been helpful, they have restricted the managers' world view to particular ways of thinking. According to them, one way of breaking out of this trap is by the generation of more metaphors and, as a result, more new ways of seeing. The authors also go on to indicate that metaphors are not only useful for macro perspectives but also play a critical role in some of the processes like new product development. They conclude by briefly highlighting the techniques that are available for generating metaphors and how managers could make use of them for effectively managing their organizations.


Based on the historical data of higher education matriculation collected from the provin- cial newspapers,this article analyzes and evaluates the changing processes of the provincial and re- gional differences in the higher education opportunity since China's rapid expansion of higher educa- tion in 1999 through constructing the indicators of the gross enrollment rates and by applying Theil index and Gini Coefficient.The outcome shows that the inequality among provinces has declined ev- idently but the polarization from the most advantaged to the most disadvantaged among some of prov- inces has become intensified.As a result,the author develops certain analysis and explanation from the aspect of synthetical-balanced restriction of non-balanced development of higher education,and provides several policy-making suggestions to solve these regional disparities.


The article introduces the construction and planning condition of eastern campus in General Road section of Nanjing University of Aeronautics and Astronautics from general condition of land,necessity of construction,principle of planning,building size,fund resources and effect analysis of investment,and shows that construction of the university has significances to promote construction of national defense and development of aerospace industry.


Multi-level capillary holes are designed to replace a single long capillary hole which is difficult to implement and unsuitable for an adjustable measurement range.Flow field characteristic analysis of multi-level capillary holes is performed.Analytical study results indicate that each capillary hole bears equal pressure drop,there is no obvious pressure drop on large holes between multi-level capillary holes.The relationship between differential pressure and flow rate through multi-level capillary holes is still linear.And the flow rate through multi-level capillary holes equals to that through a single one with the same effective length multiply with a loss factor on the condition that multi-level holes bearing the same differential pressure.


Donald Rayfield. Understanding Chekhov. A Critical Study of Chekhov's Prose and Drama. London: Bristol Classical Press, 1999. 295 pp., L15.95, paper. Donald Rayfield's latest book on Chekhov is written in the traditional format of "life and works." Its approach is structural, inter-textual, and biographical. The book eliminates footnotes and refers to the works by titles without page numbers. The book begins with biographical details and discusses the significance of Chekhov's two professions: medicine and writing. The need to support himself and his family resulted in the publication of Chekhov's first humorous pieces, which were written between 1880-85 and were infused with irony and/or parody. Once his financial burden decreased, Chekhov was able to devote himself to serious works. By 1888 Suvorin enabled Chekhov to write only what the author was artistically interested in portraying. One can discern Tolstoy's morality penetrate his writings. Rayfield says that in 1886 Chekhov wrote stories that could be classified as (1) those in which right clashes with wrong and reaches a synthesis and (2) those in which contemporary, philosophical problems are taken up. In 1887 with Suvorin's help Chekhov revisited the towns, countryside, farms, and monasteries that he had known as a boy. That year he wrote the remarkable story, "The Steppe." In the stories that followed in 1888-1889 psychological analysis, along with Tolstoy's technique of monitoring and analyzing every twitch of character's bodies, became a trend in Chekhov's stories. Chekhov had a more turbulent career as a playwright than as a storywriter. Most of the plays that he wrote later can all be seen as variations on one play (now called Platonov) written in his youth. Chekhov also wrote the plays Ivanov and The Wood Demon, which were failures. He did not get back to writing a play for seven years; instead, he absented himself from the literary forefront by going to Sakhalin in 1890. In 1895 Chekhov produced his monumental "The Island of Sakhalin" in which he emphasized the potential for goodness in every individual and evil in every hierarchy. On his return from Sakhalin, Chekhov settled on his estate in Melikovo (1893-1899). According to Rayfield this was a time of both contentment and frustration. Chekhov started showing the ambivalence in his attitude towards other people, which was to continue through his later years. He feared loneliness and at the same time complained of lacking privacy. Women played a greater role in his life. Chekhov's reading at this time was unexpectedly varied. He became familiar with Hauptman, Ibsen, Strindberg, and Maeterlinck. He was fascinated with the stream of innovations employed in their plays. This helped him overcome the trauma of failure in the play The Wood Demon. With this new surge of interest came The Seagull, which broke the traditional canons and argued for two possible approaches: conservative and experimental. …


in recent years, in the field of psychological treatment, the use of principle of mindfulness presents the condition of \"race\". Mainly displays in the team, training, technology rich huge expanding and related effects, etc., has achieved good results. But easy to be misunderstood in the related research results, the major factors influencing the practice without being taken seriously, \"wandering\" mindfulness to use easily. Fit the actual situation of practitioners, the psychological consultant appropriate \"self\" and so on should be a effective way to guard against \"wandering\". Mindfulness Used in \"Fast\" Mindfulness is one of the earliest literature sources (mindfulness) buddhist \"four mindfulness through\", sometimes also called \"zen\" concept, is the core of primitive Buddhism zen method. In the context of the Buddhism, the (pali text: sati; English: mindfulness) is a relatively stable state of mind, individuals will mind fixed on an object, dedicated to detect, is called. As a kind of mental state, read will keep taking individuals thought focus, stable, no ease, no fleet, which holds good thoughts and behavior, form a kind of the power of diligence, namely mindfulness. As a \"mindfulness decompression therapy\", the founder of the card ba jin (j.k. abat Zinn) think: \"mindfulness is consciously aware of (On Purpose), living In the Moment (In the Present Moment) and do not judge (Nonjudgementally)\" [1]. In the condition of mindfulness, people can focus on the present situation, not to judge a conscious awareness to present the experience of another moment. And if left mindfulness, people will be those who do not consciously and the behavior of inertia, and live in the inertia of driven by past experience. Mindfulness \"can help us from this state of inertia and the lack of consciousness, wake up and to touch the lives of all possibilities, consciously and unconsciously,\" [2]. It seems that mindfulness is purposefully attention, perceives the present of everything, and do not make any judgement, analysis and response. S and eighty s, 20th century mindfulness principle was introduced to the west, and immediately brought to the attention of the psychological educational world, by Joe, ba jin and scholar's efforts to improve and integrate, become the contemporary one of the most important concepts and techniques of psychological treatment. Following mindfulness decompression therapy (MBSR) was born in 1979, has appeared after receiving therapy (ACT), the dialectical behavior therapy (DBT) and mindfulness cognitive therapy (MBCT) such as the name of the contemporary psychotherapy, and widely used in the treatment of symptoms such as pain, depression and anxiety. In dealing with the relationships, parent-child relationships, aging and death issues, such as the effect of mindfulness techniques also increasingly remarkable. In conclusion, in the field of psychotherapy in recent years, the use principle of mindfulness to show the status of the \"fast\", its main performance in the following respects. 4th International Conference on Management Science, Education Technology, Arts, Social Science and Economics (MSETASSE 2016) Copyright © 2016, the Authors. Published by Atlantis Press. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/). Advances in Social Science, Education and Humanities Research, volume 85


We investigate the automatic generation of topic pages as an alternative to the current Web search paradigm. We describe a general framework, which combines query log analysis to build aspect models, sentence selection methods for identifying relevant and non-redundant Web sentences, and a technique for sentence ordering. We evaluate our approach on biographical topics both automatically and manually, by using Wikipedia as reference.


Transforming growth factor β (TGF-β) signals through two transmembrane serine/threonine kinases, known as TβR-I and TβR-II. Several lines of evidence suggest that TβR-II acts as a primary receptor, binding TGF-β and phosphorylating TβR-I whose kinase activity then propagates the signal to unknown substrates. We report an interaction between TβR-I and the farnesyl-protein transferase-α subunit (FT-α) both in a yeast two-hybrid system and in mammalian cells. These findings raise the possibility that TGF-β might regulate cellular functions by altering the ability of FT-α to catalyze isoprenylation of targets such as G proteins, lamins, or cytoskeletal components. However, we provide evidence that TGF-β action does not alter the overall protein isoprenyl transferase activity in Mv1Lu mink lung epithelial cells. In fact, the β subunits of farnesyl transferase and geranylgeranyl transferase, which are necessary for the activity of FT-α, prevent the association of FT-α with TβR-I. Furthermore, farnesyl transferase activity is shown to be dispensable for TGF-β signaling of growth inhibitory and transcriptional responses in these cells. These results suggest that the interaction between TβR-I and FT-α does not affect the known functions of these two proteins.


The metabolic profile and the erythrocytic levels of lipid peroxidation, glutathione peroxidase and superoxide dismutase activities were determined along with the plasma levels of vitamin E, s-carotene and vitamin E in different growth stages of female buffalo, viz. calves (neonatal, transitional and ruminant), heifers (prepubertal and pubertal), pregnant (early, mid and late), postpartum lactating and dry buffaloes. The lipid peroxidation level decreased with age and increased during pregnancy. The superoxide dismutase activity was higher during late pregnancy than early pregnancy. The levels of s-carotene, vitamin E, vitamin C, cholesterol and HDL-cholesterol were higher in heifers than the calves. During pregnancy, s-carotene and vitamin E levels decreased whereas lipid peroxidation increased.


This study used a decomposition analysis model to investigate the trends in area, production and yield of fennel in Nagaur district and Rajasthan state. The constraints faced by the fennel growers in producing and marketing fennel were assessed using the Garret ranking technique. The results revealed that the growth rates in area, production and productivity of fennel were significantly positive for both the Nagaur district and the Rajasthan state. Constraint analysis indicated that lack of knowledge about plant protection chemicals was the principal technical constraint, unavailability of quality seed variety was the main input constraint and fluctuation in the market price of the fennel seed was the primary marketing constraint. It was suggested that future government policy should strengthen crop breeding programs to develop new drought-resistant high-yielding varieties in Rajasthan. The farmers can be encouraged for contract farming and future trading of fennel to counter price fluctuations.