Barriers or costs? Understanding faculty resistance to instructional changes associated with curricular reform Obstacles ou coûts? Pour mieux comprendre la résistance du corps professoral aux changements pédagogiques liés à la réforme des programmes d'études Ingrid Price,1 Glenn Regehr1 1University of British Columbia, British Columbia, Canada Correspondence to: Ingrid Price; email: firstname.lastname@example.com Published ahead of issue: April 27, 2022; published on July 6, 2022. CMEJ 2022, 13(3). Available at https://doi.org/10.36834/cmej.74041 © 2022 Price, Regehr; licensee Synergies Partners. This is an Open Journal Systems article distributed under the terms of the Creative Commons Attribution License. (https://creativecommons.org/licenses/by-nc-nd/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is cited. Over the past century, there have been recurrent calls for change to our methods of education in the health sciences. However, despite repeated efforts at curricular reform, many authors have suggested that there has been surprisingly little meaningful impact on the learning experience of students in the health sciences.1,2,3 This cycling between calls for change and ineffective curricular reform has been coined the "carousel of change"4 and there has been recent interest regarding what it may take to get off this carousel.2,3,4 Bridges and Bridges5 have suggested that educational changes of any sort, regardless of their conceptual soundness, ultimately succeed or fail based on whether individual instructors, students, and administrators do things differently. This has led some to speculate that making curricular changes without effectively supporting instructors to enact these changes on the ground may be one of the reasons we continue to cycle between calls for change and subsequent ineffective efforts at curricular reform.3


KEMI-TORNIO UNIVERSITY OF APPLIED SCIENCES, Social Services Degree programme: Master of Social Services Author(s): Tikkanen Sari Thesis title: Orientation material to the Käpymetsä day care centre Pages (of which additional): 52 (5) Date: 28.5.2014 Thesis instructor(s): Helavirta Susanna & Viinamäki Leena The goal of my development project was to achieve a working orientation folder to the Käpymetsä day care centre. A significant part of the orientation folder was to bring forth special operational features of a 24-hour day care centre and to achieve uniform a approach to different practices to help everyday tasks. Additionally the goal was to determine, what significance the Kapymetsa staff thought the orientation folder has. The development project has been carried out as an action research, which was implemented in the Käpymetsä day care centre between the years 2012-2013. I gathered materials to the orientation folder from an inquiry to the Käpymetsä day care centre staff and group interviews. After the trial of the orientation folder I made an additional survey, about what the staff thought about the folder and what significance orientation the folder was considered to have. In the theoretical reference I go through orientation at on a general level, as well as a functional working community. The concrete result of the development project was a orientation folder to the Käpymetsä day care centre. The orientation folder functions as a supportive and assisting tool in practical work and is an important information package to new employees, substitute workers and students. The Orientation folder was considered as a very important tool to comprehensive work and it received and overall satisfaction.


Aesthetic education not only has a very important position in higher vocational education, but also an important content of higher vocational Chinese teaching. However, the current imbalance between material and spirit and the dissolution of cultural spirituality have seriously affected the implementation of aesthetic education in higher vocational education. Because aesthetic education and higher vocational Chinese teaching have a very good fit, from the perspective of course content and the implementation of aesthetic education, the higher vocational Chinese course does have certain unique advantages. Therefore, from shaping the beautiful mind, creating the beautiful character, improving the understanding of beauty, enhancing the perception of beauty, cultivating the taste of beauty, cultivating the emotion of beauty, and the ability to create beauty, All can enable students to get the cultural influence of truth, goodness and beauty in the subtlety of higher vocational Chinese.


In this paper, we combine Cell Nerve Network (CNN) and polynomial to processed radar image. Then analysis the image with polynomial fitting. We enlarge eight times of the key part of the radar image, and then detect the edge of the image. Dug some data as information. At last we find some regular to distinguish the cloud with hail or not. We find those are useful way for forecasting of hail.


ABSTRACT.
 The recent discovery of a new Colias species from the central Arctic of Canada, a region with a relatively small, well-studied butterfly fauna, has remained relatively unknown among North American lepidopterists. The status of this species, C. rankinensis Verhulst, as a species distinct from other Arctic Colias has also been treated with skepticism. Colias rankinensis was documented from only a single locality globally, from a region where thousands of Colias specimens were collected during the Canadian Northern Insect Survey in the 1950s, as well as later in the 1980s. Many of these specimens were subsequently examined during the course of revisionary work on the genus Colias in the 1980s. In light of the discovery of C. rankinensis, the identification of central Arctic Colias 'hecla' specimens is critically re-examined, revealing that two phenotypes, corresponding to C. rankinensis and C. hecla Lefèbvre, occur sympatrically in the central Arctic. A differential diagnosis, adult illustrations and distribution map of C. rankinensis is provided, and the taxonomies of C. hecla taxa are reviewed.


In this paper, we investigate empirically the effect of two domestic airline alliances. We find that both alliances benefited consumers—average fares fell by about 5–7 percent after the creation of the alliances on those city pairs affected by the alliances; we find that total traffic increased 6 percent after the creation of at least one of the alliances. We also find that the average fare and traffic effects arise in part because the alliance partners' rivals respond to the increased competition from an alliance. Finally, we find that the size of the alliance effect on average fares depends on the prealliance level of competition on a city pair, with the effect being larger on those city pairs where the level of competition was initially relatively low.


In the peripheral quarters of Yaounde city, population settlement is not regulated according to
particular standards of land-use. The Mingosso watershed, which covers a surface area of 3.856 km²
and which is administratively located in the Yaounde 6th district, was studied to identify the impacts of
this type of settlement upon the flow and the quality of groundwater. The physico-chemical variation of
groundwater, a bacteriological analysis of water and a survey named "water-population-habitat" were
carried out. The population growth rate between 2000 and 2005 was 24.55%. Without town planning,
91.2% of the population settled within the watershed, are not connected to piped supply network of
drinkable water, leading to an increasing demand for groundwater wells and the degradation of overall
aquifer quality. Groundwater has a diffuse mineralization, which is higher in densely populated zones
than in zones under construction with a low population density.


African leaders have welcomed the Climate Summit held at the United Nations in New York in September 2014, and say it increases the likelihood that a meaningful global climate agreement will be reached in Paris in 2015. The summit was hosted by UN Secretary-General Ban Ki-moon to mobilize support for a strong climate agreement and to catalyse climate action.


The control system of the EV directly decides the capability of the EV. The fuzzy control in the control system is designed, and a practical design project is given out. The emulational result shows that this project can improve the electric vehicle's control real time and stability.


This article reviews the causes of accidents in the construction industry, due to the state of technology, technological processes and the human factor, analyzed and given to the author's definition of culture of safe work, outlined the main approaches to the definition of the efficiency of the labour protection management system, provides criteria and indicators of the formation of the culture of safe work of the individual-formal and collective level, is used as a means of increasing the effectiveness of the system of management of labour protection.


 A_CL1_1: choose the best-performing classifier for each concept from all the following runs and an event detection method.  A_CL2_2: (visual-based) choose the best-performing visual-based classifier for each concept from runs A_CL4_4, A_CL5_5, and A_CL6_6.  A_CL3_3: (visual-text) weighted average fusion of visual-based classifier A_CL4_4 with a text classifier.  A_CL4_4: (visual-based) average fusion of A_CL5_5 with a lexicon-spatial pyramid matching approach that incorporates local feature and pyramid matching.  A_CL5_5:(visual-based) average fusion of A_CL6_6 with a context-based concept fusion approach that incorporates inter-conceptual relationships to help detect individual concepts.  A_CL6_6: (visual-based) average fusion of two SVM baseline classification results for each concept: (1) a fused classification result by averaging 3 single SVM classification results. Each SVM classifier uses one type of color/texture/edge features and is trained on the whole training set with 40% negative samples; (2) a single SVM classifier using color and texture trained on the whole training set (90 videos) with 20% negative samples.


In this paper, a generative model based method for recovering both the shape and the reflectance of the surface(s) of a scene from multiple images is presented, assuming that illumination conditions are known in advance. Based on a variational framework and via gradient descents, the algorithm minimizes simultaneously and consistently a global cost functional with respect to both shape and reflectance. Contrary to previous works which consider specific individual scenarios, our method applies to a number of scenarios – mutiview stereovision, multiview photometric stereo, and multiview shape from shading. In addition, our approach naturally combines stereo, silhouette and shading cues in a single framework and, unlike most previous methods dealing with only Lambertian surfaces , the proposed method considers general dichromatic surfaces.


In this paper,the control system of brushless DC motor based on TMS320F2812 is given.The rotor position measure circuit,posture current measure circuit,drivers circuit.and safeguard circuit are discussed detailedly,and the corresponding hardware circuit is preseened.In the three loop of control system,a fuzzy PI controller in position controller loop and a Fuzzy PID controller with self-adjusting parameters is adopted in the speed outer loop and a current hysteresis controller is adopted in the current inner loop.This design project have a trait of simple circuit、strong reliability and a high applications values.At the same time, the reasonability and validity have been testified by the test results.


Forest restoration thinning has the potential to enhance structural complexity and accelerate development of large trees important to wildlife, aesthetics, and wildfire resistance. These are key objectives for restoration of even-aged secondary forests within Redwood National Park in Humboldt County, California, USA. We evaluated tree growth and stand structure 10 years after two thinning methods were applied at two intensities in a 40-year-old mixed redwood (Sequoia sempervirens (Lamb. ex D. Don) Endl.))/Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco var. menziesii) stand. Heavy thinning enhanced diameter growth of redwood and Douglas-fir trees more than light thinning. Crown thinning generally enhanced structural diversity more than low thinning, and structural diversity increased progressively over the 10 years following thinning. Understory plant richness fluctuated between measurement years. Heavy thinning enhanced understory shrub cover. The fastest-growing trees in heavily-thinned stands were much more likely to sustain bear damage, especially redwood trees. Overall, different thinning methods and intensities induced a different suite of outcomes, yet none restored redwood dominance, but all treatments enhanced some other ecosystem values important for old-growth restoration such as large overstory trees, understory plant and shrubs, and elements of structural complexity including tree-size variability, snags, down logs, and trees exhibiting stem or top damage.


The idea that certain people are predisposed to criminality as a result of genetic inheritance is difficult to reconcile with the politics of a revolutionary like Mandela because such a theory belongs to crude biological determinism of the sort embraced by fascists like apartheid officials.


One way to reduce energy consumption in wireless sensor networks is to reduce the number of packets being transmitted in the network. Data aggregation technique, in which packets with related information are combined together in intermediate nodes before further forwarding towards their destination, shown to be a good solution for this purpose. It is clear that more related information along the paths each packet traverse results in higher aggregation ratio. If the information each node has, varies from time to time, finding paths along which more nodes with related information exist becomes a complicated task. In this paper, a learning automata based data aggregation method in sensor networks will be proposed. Each node of the sensor network is equipped with a learning automaton which learns the path along which the aggregation ratio is maximum. Simulation results show that the proposed method performs well in situations where nodes having related information vary during the network's lifetime.


The purpose of this study is to investigate different NDT-methods for weld inspection in an objective manner. Test objects are produced with known variation of flaws: internal pores, surface and in ...


Massively parallel finite element methods for large-scale computation of storm surges and tidal flows are discussed here. The finite element computations, carried out using unstructured grids, are based on a three-step explicit formulation and on an implicit space-time formulation. Parallel implementations of these unstructured grid-based formulations are carried out on the Fujitsu Highly Parallel Computer AP1000 and on the Thinking Machines CM-5. Simulations of the storm surge accompanying the Ise-Bay typhoon in 1959 and of the tidal flow in Tokyo Bay serve as numerical examples. The impact of parallelization on this type of simulation is also investigated. The present methods are shown to be useful and powerful tools for the analysis of storm surges and tidal flows.


The purpose of this note is to establish, by finite difference methods, some of the properties of two probability distributions: (1) the distribution of the sum of n independent variates, for each of which every value in the interval (0, 1) is equally probable; and (2) the distribution of the sum of n independent variates, each of which must take one of f equally probable values, 0, 1, 2, …, f –1. For brevity we shall refer to these distributions as (1) the continuous case and (2) the discrete case. The continuous case is important because it gives a solution to a problem that often arises in practical computing: 'If n numbers, which are all "rounded-off' at the same [decimal] place, are added together, what is the chance that the total will be the correct (rounded-off) total, or will be 1, 2, etc., different in the last place from this correct (rounded-off) total?' (Forster, 1947). Laplace (1776) gave a proof of the continuous case; and later (1812) gave a proof of the discrete case, from which, by a limiting process, he derived the result for the continuous case. The result for the discrete case had, however, been published much earlier by de Moivre (1711), and proofs had been published by de Montmort (1713) and de Moivre (1730). Laplace's proofs are long and difficult to follow; but, as far as I can discover, no later alternative proofs were put forward until Rietz (1924) gave a much simpler proof of the continuous case. Irwin (1927) used characteristic functions to prove the continuous case; and Hall (1927) gave a remarkable geometrical proof of the continuous case and derived a general expression for its moments.


Hermann Weyl's papers on the representation of semisimple Lie groups (1925-26) stand out as landmarks of twentieth century mathematics. The following essay focuses on how Weyl came to write these papers. It offers a reconstruction of his intellectual journey from intense involvement with the mathematics of general relativity to that of the representation of groups. In particular it calls attention to a 1924 paper by Weyl on tensor symmetries that played a pivotal role in redirecting his research interests. The picture that emerges illustrates how Weyl's broad philosophically inclined interests inspired and informed his creative work in pure mathematics.


According to the resources performance and status information provided by grid monitoring system, this paper adopts a trend-based time series prediction algorithm to predict short-term performance of the resources. Experiments show that the improved mixed trend-based prediction algorithm tracks the trend of data changes by giving more weight, simultaneously takes the different situations of data increases and decreases into account, so the improved algorithm is superior to the pre-improved and it improves the accuracy of the prediction effectively.


During the late 1950's a Department of Defense agency decided the potential for the production of a very high temperature electronic device using single crystal boron justified an extended study of the chemistry and metallurgy of the element applying techniques then being used on silicon. These studies led to the first International Conference. The response to that conference led to a continuing series of conferences, all held in Europe until now. This paper discusses work on the production of high purity single crystals, and their evaluation. These studies led to the use of this high purity boron to produce arsenides and phosphides and their evaluation. A whole new area of study was made possible by this effort in that high purity isotope of boron are now available for use in all these evaluations. Isotopic boron has proven to be of use in electronics, medical applications and of course in nuclear physics. The nuclear applications are for high purity compounds including oxides, carbides and nitrides. Exa...


In an elegant recent paper \cite{geng2022conway}, Geng and Xia settled the question of the infinite divisibility of the Conway--Maxwell--Poisson distribution, using in large part several results from complex analysis. In this note we show how these complex analytic methods can be circumvented, thereby giving a proof of their result which is completely elementary.


This paper presents an example of a method for identifying incremental productivity of inactive watered-out wells in complex reservoir structures with edge water. The method targets inactive/marginal wells associated with bypassed oil reserves and forecasts the potential of these wells through the use of dual well completions with downhole water drainage Downhole Water Sink (DWS) technology. In DWS wells, the top completion produces oil as the water inflow is diverted by the bottom completion acting as water drain (or sink). Described is the first step of the method, a geological analysis of reservoir compartmentalization and connectivity. The studied wells produced from a cross-bedded sand channel that had eroded the shale barrier between two normal sequence sands. The analysis identified hydraulic communication of the two sands. The second step of the presented method involved an analysis of the reservoir and well production records to diagnose pathways of fluid movements leading to un-swept oil and well invasion with water. The lower KF sand was water flooded for ten years before the A-3 well watered out. The production data implied water coning. Moreover, displacement calculations indicated that a large amount of the oil in the KE reservoir was unswept, leaving considerable amount of bypassed reserves. The paper conceptualizes why the bypassed oil could not be recovered from these wells, economically, with or without additional water flooding. Production schemes were designed for comparison. The system was modeled with a reservoir simulator and the results were compared with the other conventional solutions. The results clearly show a marked improvement with the use of DWS. The results indicate improved potential commercial development.


References and further information . Cancer Research UK. (2012). Cancer incidence by age. Retrieved from www.cancerresearchuk.org/ cancer-info/cancerstats/incidence/age/ . Drake, R., Vogl, W., Mitchell, A., & Gray, H. (2010). Gray's anatomy for students, second edition. Philadelphia, PA: Churchill Livingstone/Elsevier . Gleeson, M., Herbert, A., & Richards, A. (2000). Management of lateral neck masses in adults. British Medical Journal, 320(7248), 1521 . Griffiths, E. (1979). Incidence of ENT problems in general practice. Journal of the Royal Society of Medicine, 72, 740–742 . Humber and Yorkshire Coast Cancer Network. (2010). Primary care referral guidelines head, neck & thyroid cancers. Retrieved from www. hyccn.nhs.uk/NetworkGuidelinesAndPublications/ HeadNeckNSSG.htm . Lalwani, A. (2008). Otolarygology head and neck surgery current diagnosis and treatment. UK: Lange . Longmore, M., Wilkinson, I., Davidson, E., Foulkes, A., & Mafi, A. (2010). Oxford handbook of clinical medicine, eighth edition. Oxford, UK: Oxford University Press . NICE. (2005). Guidelines for suspected cancer. Retrieved from www.nice.org.uk/nicemedia/live/ 10968/29814/29814.pdf . NICE. (2010). Clinical knowledge summaries: Neck lumps. Retrieved from http://cks.nice.org.uk/ neck-lump#!topicsummary . Oxford Cancer Intelligence Unit. (2010). Profiles of head and neck cancers in England: Incidence, mortality and survival. Retrieved from www.ncin.org. uk/view?rid1⁄469 . RCGP. Clinical example 3.15: Care of People with ENT, oral and facial problems. Retrieved from www.rcgp.org.uk/gp-training-and-exams/ / media/Files/GP-training-and-exams/Curriculum2012/RCGP-Curriculum-3-15-ENT-Oral-and-FacialProblems.ashx . Thander, M. A., & Jonas, N. E. (2004). An approach to the neck mass. Retrieved from www.ajol.info/index.php/cme/article/download/ 43974/27491m


And in the same epistle, where I say of the civil philosophy: "It is no ancienter than my book De Cive"; these words are added: "I say it provoked, and that my detractors may see they lose their labour". But that which is truly said, and upon provocation, is not boasting but defence. A short sum of that book of mine, now publicly in French, done by a gentleman I never saw, carrieth the title of Ethics Demonstrated. The book itself translated into French, hath not only a great testimony from the translator Sorberius, but also from Gassendus, and Mersennus, who being both of the Roman religion had no cause to praise it, or the divines of England have no cause to find fault with it. ("Six Lessons", 1656, p. 333; the French In an age when political thinkers were writing books full of quotations of ancient and modern authors, Thomas Hobbes of Malmesbury (1588-1679) developed a philosophical system which was based on scientific method rather than on the authority of books. He emphasized that the absurdities that philosophers fall into are actually due precisely to a lack of method and to the habit of quoting other thinkers as if the truth was to be found in their words. It is certainly not inappropriate to read what philosophers, historians, and poets wrote, whether for pure amusement or to find intellectual spurs useful for one's own research and speculation; but the written word should not be confused with the truth. In the investigation aimed at discovering the truth in political matters, the philosopher must use his own intellect, relying on the strength of reasoning. Thus, political philosophy becomes a science: the science of "consequences from the accidents of politic bodies". With his reflections on scientia civilis, Thomas Hobbes may be considered the inventor of political science.


We report on the design of an imaging microellipsometer enabling the generation of maps of the two ellipsometric angles Δ and Ψ. Areas of 60×200 μm2 are imaged at a rate of 1–2 images per minute. By working at angles (45°) much smaller than the Brewster angle (≈73° for Si/SiO2/air) a lateral resolution of 3 μm and a height resolution of 5 A is achieved. The performance is demonstrated by thickness measurement of a laterally structured polymer film and a transient thickness measurement of dewetting fluid film of n-hexadecane on a Si/SiO2 wafer.


Abstract This paper first introduces the development of arc suppression coil with automatic tracking and compensation (ATCASC) in China. Then the authors give different classification of the ATCASC, and describe in detail the configuration, the main advantages and disadvantages of each ATCASC. Finally the common problem that the current ATCASC cannot compensate for the active component and harmonic component of the single-phase-to-ground fault current is pointed out. Based on this, the authors indicate that the "zero residual current ASC" will be a new research direction of the neutral point grounding methods and the ATCASC in China.


Zirconia was prepared by firing the coprecipitate from ZrOCl2and AlCl3mixed aqueous solution with ammonia. When fired above 600°C, the products were fine crystalline tetragonal zirconia of crystallite size <10 nm. In previous studies, the tetragonal phase had been assumed to be a (Zr1−x4+Alx3+)O2−x/2solid solution, where x≤ 0.25. However, X-ray diffraction pattern simulation and Al K-edge XANES spectroscopy confirmed the present product to be a mixture of t-ZrO2fine powder with a small amount of δ-Al2O3of very low crystallinity, even below the expected compositional range of x≤ 0.25 in the (Zr1−x4+Alx3+)O2−x/2solid solution.


Forum: Recent Developments in Cancer Nursing Overview 119 Patsy Yates Developments in Supportive Care: Implications for Nursing 120 Catherine Pigott, Sanchia Aranda and Annabel Pollard Caring for Families of People with Cancer: Evidence and Interventions 123 Linda Kristjanson Cancer Care Coordinators: Realising the Potential for Improving the Patient Journey 128 Patsy Yates Issues in Nurse Practitioner Developments in Australia 132 Glenn Gardner A Review of Cancer Nursing Workforce Issues in Australia 134 Linda Barrett


Thank you very much for downloading decorative patterns of the ancient world. As you may know, people have search numerous times for their favorite books like this decorative patterns of the ancient world, but end up in malicious downloads. Rather than reading a good book with a cup of coffee in the afternoon, instead they are facing with some malicious bugs inside their computer. decorative patterns of the ancient world is available in our digital library an online access to it is set as public so you can download it instantly. Our digital library spans in multiple countries, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the decorative patterns of the ancient world is universally compatible with any devices to read.


Spontaneous cerebrospinal fluid (CSF) leaks have imaging findings consistent with chronically elevated intracranial pressure, such as empty sella. Meckel's cave is a CSF‐filled space that houses the trigeminal ganglion at the cranial base. Our objective in this study was to evaluate "dilated" Meckel's cave as a radiologic sign in patients with elevated intracranial pressure spontaneous CSF leaks and compare the dimensions with those from a control cohort.


http://heart.bmj.com/content/95/19/1619.full.html Updated information and services can be found at: These include: References http://heart.bmj.com/content/95/19/1619.full.html#related-urls Article cited in: http://heart.bmj.com/content/95/19/1619.full.html#ref-list-1 This article cites 38 articles, 30 of which can be accessed free at: Open Access is properly cited. use, distribution, and reproduction in any medium, provided the original work Commons Attribution Non-commercial License, which permits unrestricted This is an open-access article distributed under the terms of the Creative


With a removable stable during sampling pixel data, displaying an image of the ghost-free image display apparatus. It is equipped with a plurality of pixels arranged in the pixel position data signal lines arranged in a matrix 112 and a plurality of scanning signal lines 110 intersect to form an image on the display unit 100 configured. Scanning signal line selection circuit are sequentially supplied to the scanning signal to the scanning signal line 110. Phase-development circuit 32 extracts an image signal, outputting a plurality of phase-developed signals in parallel. Sampling phase expansion circuit 106 extracts pixel data signal, the data signal supplied to the data signal line 112. Sampling signal generating circuit 104 generates and supplies a signal sampling circuit 106 samples.


This research deals with the teaching of product design methodology in Design, Industrial Design and similar courses which offer a bachelor's degree in product design within Graduate Institutes. The methodologies applied to the subjects concerned will be discussed in this paper, as well as their effectiveness in preparing alumni to tackle complex problems related to both sustainability and the sustainable development of our society. Founded on extensive field research, which led to the main publications introduced by the Design courses all over Brazil, the research also enquired Professors who teach both product design and product design methodology at Graduate Institutes, as well as their alumni. The main publications employed were analyzed, and their fundamental characteristics were highlighted. A timeline regarding sustainability and a map of complexity aided in comparing and criticizing the product design methodological structures currently employed, having as a final outcome a critical discussion and an indication of necessary changes in the teaching of methodology in Design courses in Brazil


It has long been known that the Robin Hood plays are related in some way to the Robin Hood ballads, but just what this relation is has not been fully studied. Did the plays borrow from the ballads, or the ballads from the plays ? Or do both go back to a common oral tradition ? The material which will help us answer these questions is very scanty. There are three fragmentary Robin Hood plays, one certainly before 1475, the other two of unknown date.' Of the


This paper presents an implementation of a digital image-processing system for use in general realtime applications. The system is composed by two major sections: digitizer and image processor. The digitizer can capture an image frame from standard video signal and convert it into digital format. The pixel stream is then fed directly into the image processor section, which is implemented by using a Field Programmable Gate Array (FPGA), and thus can be programmed to perform any operations within a 3 x 3 mask. Its output pixels are at the same rate as that of the video scans. An experimental result is given with the FPGA programmed as a binomial mask, for the noise reduction purpose. Key-Words: FPGA, Real-time, Digitizer, Image processor, Image-processing system.


Currently there is considerable interest in developments leading to new advanced high-strength sheet steels (AHSS) for automotive and other transportation applications that demand high strength, light weight materials. Design requirements will involve material properties with strengths greater than currently available dual phase and transformation-induced plasticity (TRIP) steels (steels in this group are referred to as the "First Generation" of AHSS), with good ductility and formability, but produced at a cost less than the high ductility stainless steels or high manganese TWIP steels (materials referred to as the "Second Generation" of AHSS). Recent studies have shown that materials that satisfy the required property/cost combinations will include complex microstructures containing high amounts of retained austenite in combination with a high strength constituent that may be ultrafine grained ferrite, martensite, bainite, and/or combinations of ferrite-based constituents. In this article, selected methodologies leading to the production of new AHSS materials will be reviewed and assessed to provide a framework for consideration of new concepts and processing routes that will be required in production operations.


The behaviour of systems characterised by a closed interaction of software components with the environment is inevitably subject to perturbations and uncertainties. In this paper we propose a general framework for the specification and verification of requirements on the behaviour of these systems. We introduce the Evolution Temporal Logic (EvTL), a stochastic extension of STL allowing us to specify properties of the probability distributions describing the transient behaviour of systems, and to include the presence of uncertainties in the specification. We equip EvTL with a robustness semantics and we prove it sound and complete with respect to the semantics induced by the evolution metric, i.e., a hemimetric expressing how well a system is fulfilling its tasks with respect to another one. Finally, we develop a statistical model checking algorithm for EvTL specifications. As an example of an application of our framework, we consider a three-tanks laboratory experiment.


The addition of colour information to the computation of range/scene flow is proposed to improve its accuracy and robustness to ambiguities. This is applied in the form of additional optical flow constraints from aligned colour image data. Combining constraints gives improved velocity displacement fields for both synthetic and real datasets over using depth alone, or in using depth plus intensity. This ultimately has benefits for the processing of dense, temporal depth data obtainable from novel video-rate 3D capture systems.


Despite its worldwide popularity, Israel-originated Krav Maga is still remarkably unexplored. With regards to Krav Maga's global spread, this article focuses on the 'social career' of Krav Maga in Germany and en-quires into the conditions for its success. Beginning in the 2000s, Krav Maga has rapidly resonated throughout Germany, nowadays showing a high degree of social connectivity and differentiation. Analysed through the lenses of social systems theory, Krav Maga's increasing popularity in Germany can to a significant degree be ascribed to communication – implemented in particular by highlighting relevant differences from other practices and systems of self-defence


This chapter examines government education policies in Uganda in relation to the problems of early school leavers, which is known to be a problem in the country. According to statistics from the Ministry of Education and Sports, few students (45,000 out of 180,000) who join secondary school in Senior 1 make it to their sixth and final year of secondary education. The problem of early school leaving has received little attention in terms of policy provision and support despite the introduction of universal access to and equity in education. This chapter will therefore focus on policy provisions and gaps that lead to the problem of early school leaving, examining attempts that have been made to put in place policies that could reduce the problem of early school leaving. Recommendations are made on how policies can be used to overcome the problem of leaving school early.


Global manufacturing network(GMN) creates new opportunities for international knowledge transfer,and provides great opportunities for Chinese local firms to acquire knowledge and upgrade through collaborations in GMN.This paper hypothesizes that local firm's absorptive capacity has a positive impact on local firm's knowledge acquisition and its business performance in GMN,and the association between them is moderated by network embeddedness.Using data of manufacturing firms,this paper confirms hypothesises that local firm's absorptive capacity can contribute to its knowledge acquisition and its performance;the association between understand external knowledge(one component of absorptive capacity) and local firm's knowledge acquisition is moderated by network embeddedness,and local firm's knowledge acquisition has a mediating effect on the association between absorptive capacity and it's business performance.


Studied on the monthly variation of water quality in the Han river between Kwangjang bridge to Nanji island from May to September during 1973. Comparing with the water quality in each area, the concentration of COD and MBAS in Chyeong gae stream and Anyang stream was more higher than that of the Han river. And it was considered that the streams were very polluted for the waste water influence of from Seoul city. Comparing the Han river to upper site(Kwangjang bridge) of it the upper site was not polluted but the Han river was going to polluted for the wastewater influence from Seoul city. In this experiment, the MBAS analytical value was compared statiscally with the value of DO and COD, it showed that there was the relationship between MBAS and DO, COD.


Objective:To probe into the clinical curative efficacy on patients suffering from hyperslenia in liver cirrhosis after being treated by different areas of embolization.Methods:43 cases of patients suffering from posthepatitic cirrhosis hypersplenia were chosen and divided into 2 groups.Group A had 17 cases;area of embolization was about 40%~50%.Group B had 26 cases;area of embolization was around 70%~80%.The catheter was inserted using Seldinger′s technique into the arteries of middle or lower pole of spleen and PVA granules were used as embolic material.After 3 days,1 week,2 weeks,1 month,3 months,6 months,1 year,2 years the blood routime examination was carried out.Results:After operation leucocytes and thrombocytes both ascend.However,two kinds of curative effect of different extent remain divergence.Group B is superior to Group A on efficacy.Conclusion:The curative effect of partial splenic embolization in 70%~80% is better.It is preferable to enlarge the area of embolization,if the patient′s condition permits,in order to steady the efficacy.


Abstract Background We evaluated the health-related quality of life (HRQoL) benefits of upadacitinib (UPA) induction and maintenance treatment in a phase 3 study of patients with ulcerative colitis (UC) across a broad range of patient-centered outcomes. Methods Patients received UPA 45 mg once daily or placebo as induction treatment for 8 weeks. Patients who achieved clinical response were rerandomized to receive once daily UPA 15 mg, 30 mg, or placebo as maintenance treatment for 52 weeks. The percentages of patients reporting a clinically meaningful within-person change from baseline in the Ulcerative Colitis Symptoms Questionnaire, Inflammatory Bowel Disease Questionnaire, Work Productivity and Impairment Questionnaire, 36-Item Short Form Survey, and European Quality of Life-5 Dimension 5 Levels were evaluated at weeks 2 and 8 of induction and at weeks 0 and 52 of maintenance. Results Significant improvements from baseline in all HRQoL measures except the Work Productivity and Impairment Questionnaire–absenteeism were achieved with UPA (P < .001) vs placebo as early as week 2 of induction. These improvements were sustained at week 52 with significantly more patients treated with either 15 mg or 30 mg UPA vs placebo achieving meaningful within-person change in the Ulcerative Colitis Symptoms Questionnaire; Inflammatory Bowel Disease Questionnaire; overall work impairment, presenteeism, and activity impairment; both 36-Item Short Form Survey Physical and Mental Component Summaries; and European Quality of Life-5 Dimension 5 Levels (P < .001). Conclusions Induction treatment with UPA 45 mg significantly improved HRQoL measures. A significantly higher percentage of patients who responded to induction treatment with UPA maintained clinically meaningful improvements consistently across a wide range of HRQoL outcomes after 52 weeks of maintenance therapy with UPA (15 mg and 30 mg) compared with placebo. (ClinicalTrials.gov, Numbers: NCT02819635, NCT03653026).


A renormalisation theory is developed to study the critical behaviour of self- avoiding random walks on multifractals. Critical exponents and connectivity constants are calculated for walks on a class of square multifractal lattices using a finite lattice renormali- sation. The effect of the multifractal disorder is considered for both annealed and quenched disorder .


American Literature was a great compilation of prose, nonfiction and poetry written by many colonial writers from about 1600 to till date. The 1950's had given a thirst for the writers to produce more new literatures with a view that were focussed mainly on the freedom and social constraints by adopting unique methods to enlighten the future readers. It was a time of new  inventions in transport and communication where the American Literature had seen new challenges.Their writings were challengedand new forms of books evolved. Advancement in communication made the whole world know about American literature which made it more familiar with more countries where their voices could be heard from remote corners of the world and reached the American audience.The twentiethcentury, hadan exertion to seize the uncertainty and confusion of life in the contemporary world where most of the writers hadturned away from the traditional way and concluded the stories without any tenacity. America had been acclaimed as the most powerful nation in the world and every American were skilled workers and had a dream where every part of the city in the country was flourishing with life, liberty, and pursuit of happiness.


This guide will provide multidisciplinary resources to support research and documentation for Irish Material Culture General information and broad overviews


Professional medical organizations need to educate physicians about depression and suicide in medical school and continuing education programs, develop policies that encourage physicians to seek help, and impose an accountability system for detecting depression in patients. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.


Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, Kentucky 40536-0596, and Laboratory of Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, and the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 Current address: Department of Pharmaceutical Sciences, Midway College School of Pharmacy, P.O. Box 1847, Paintsville, KY 41240


AbstractCoal fly ash from a power plant was leached using HCl. Factors that influenced the leaching process, such as the ratio of coal fly ash to Na2CO3, the HCl concentration, the leaching time, and the temperature, were investigated, and an orthogonal test was used to determine the optimal conditions for acid leaching the coal fly ash. The coal fly ash samples before and after acid leaching were analyzed by scanning electron microscopy, energy dispersive spectroscopy, and Brunauer–Emmett–Teller adsorption analysis. An aluminum leaching rate of 90.68% was obtained using the optimal values of 6 g Na2CO3, 100 g coal fly ash, 4 mol L−1 HCl, 1.5 h leaching time, and a temperature of 100°C. The concentrations of Al3+ and Fe2+ plus Fe3+ in the leaching liquid were 34.21 and 30.67 g L−1, respectively, using the optimal conditions. The coal fly ash residue had certain specific surface area and absorption features that are described. The results suggest that acid leaching offers benefits in terms of the comprehen...


Bacterial infection related to orthopaedic implants is a significant complication today. One of the ways to reduce the incidence of implant-associated infections is assumed to give antibacterial activity to surface of implant itself. We focused attention on Ag, because it has a broad antibacterial spectrum, strong antimicrobial activity and low toxicity. In the previous works, sputtering, electrochemically deposition and sol-gel coating of Ag-containing hydroxyapatite (HA) have been reported. However, since practical technique of HA coating widely used for medical and dental implants has been the "thermal spraying" technique over the last two decades, we aimed at developing the novel thermal spraying technology for Ag-HA coating with antibacterial activity. In this study, physical and chemical properties, in vitro antibacterial activity, inhibition activity of bacterial attachment, HA-forming ability, cytotoxicity and release of Ag ions of the thermal-sprayed Ag-HA coating were evaluated. HA powder containing 3wt % of silver oxide (Ag2O) was sprayed on surface of titanium disks by the thermal spraying method using acetylene torch. SEM images showed a typical structure of the thermal-sprayed coating and the X-ray diffraction (XRD) pattern of the coating showed an amorphous structure. Ag residue in the coating was determined by the elementary analysis. The coating showed strong antibacterial activity and inhabitation activity of bacterial attachment to the methicillin-resistant Staphylococcus aureus (MRSA) in fetal bovine serum (FBS). On the other hand, the coating showed fast HA-forming ability in simulated body fluid (SBF) and no cytotoxicity related to Ag contained in the coating. Therefore, it is expected that the thermal-sprayed Ag-HA coating provides antibacterial and bone-bonding ability on the surface of the implant itself. In addition, though the HA coating is generally liable to adhere bacteria, the thermal-sprayed Ag-HA coating overcomes this problem. Pre-evaluation of release of Ag ions from the Ag-containing ceramic powders indicated that the releasing behavior of Ag ions in SBFs is dependent on the existing form of Ag in the Ag-containing material. It is assumed that most of Ag components in the Ag-HA coating are not retained as metallic Ag but as Ag2O in the amorphous layer. Time-course release tests of Ag ions from the coating in FBS showed a large release rate of Ag ions until 24 h after the immersion. It is expected that the Ag-HA coating could show strong antibacterial activity at the early post-operative stage. In the repeated release testing, the amount of released Ag ions was about 6500 ppb for the first release test, after which it gradually decreased. However, a significant release amount of Ag ions was observed even after the sixth repeat test. Therefore, it was assumed that the thermal-sprayed Ag-HA coating has a slow-release property of Ag ions in FBS.


Setterfield reminds us of the importance and real power that biographies have not only for the subjects but also for the authors. Writing lives is a kind of magic and my biography on Laura Bragg (Allen, 2001) altered my life in many ways. I offer my thanks to my colleagues and my respect for their reading of my Bragg biography and for their comments. Indeed, I am humbled by their papers presented here—and honored by these scholars for offering me another opportunity to revisit my work on Laura Bragg. She was in life, and remains even now, a complex and perplexing woman.


Objective To investigate the role of the hypothalamus, medullary visceral zone (MVZ)and vagus in cerebral hemorrhage (CH) in multiple organ dysfunction syndrome (MODS) rat model.To reveal the possible regulatory mechanism of the hypothalamus-MVZ-vagus pathway in CMODS.Methods 80 Wistar rats were randomly divided into sham-operative group (n = 10), subdiaphragmatic vagotomy group (SDV, n = 10), CH group (n = 20), CH + SDV group (n = 20) and CH + vagus stimulation group (CH +SIV, n = 20).Rat CH model was made by stereotaxis injection of collagenase in caudate nucleus.Its endotoxin in serum was evaluated with a test kit.The expression of FOS in the hypothalamus and CHAT in the MVZ in the rats were examined using immunohistochemistry methods.Results Abnormality of hepatic and renal function, myocardium enzyme in CH + SDV group, CH + SIV group and CH group were more severe than those in sham-operative group and SDV group; CH + SDV group more severe than CH group.CH +SIV group were much milder than CH group.The serum endotoxin level (EU/ml) in CH group,compared with the sham-operated group, were significantly different (1.03 ± 0.25 and 0.18 ± 0.03respectively, t = 10.61, P <0.01).The expression of FOS in hypothalamus of CH + SDV group (9.3 ±2.6) were significantly higher than those in sham-operative group (2.5 ± 0.4, t = 8.17, P < 0.01) and SDV group (2.9 ±0.5, t =7.64, P <0.01), but significantly lower than those in CH group (48.6 ± 18.1,t =6.80, P<0.01); was higher in CH +SIV group than those in CH group (74.3 ±6.3 and 48.6 ± 18.1,t=4.23, P <0.01).The expression of CHAT in MVZ in CH + SDV group (138.5 ± 11.8) was significantly higher than those in sham-operative group (108.2 ±9.5, t =5.39, P <0.01) and SDV group (110.7 ±9.9, t =4.83, P <0.01), but significantly lower than those in CH group (164.4 ± 12.4, t =3.53, P <0.01); was higher in CH + SIV group than in CH group (189.4 ± 15.0 and 164.4 ± 12.4, t =3.14, P < 0.05).Conclusion Hypothalamus may be related to the nerve immunity adjustment in MODS after cerebral hemorrhage.The hypothalamus-MVZ-vagus pathway may be distinctive in CMODS.Vagus nerve may be a Bi-directional Channel of the rats following cerebral hemorrhage and MODS.

Key words:
Cerebral hemorrhage; Multiple organ failure; Disease models,animal; Endotoxins; Vagus nerve


Black men are more likely than white men to develop prostate cancer, but a new film fails dismally to investigate the problem


1-Wire Bus is a bus protocol which connects some sensors and low-speed devices with the host,such as the smart temperature sensor DS18B20,A / D chip,and so on. With the development of the internet of things,the application of these sensors will become more widespread,but their interfaces are not closely linked with the kernel, the kernel can not unify the management,so stability and reliability may not be guaranteed. In line with the premise of the Linux kernel device model,a stable 1-Wire interface is given. the controller will be divided into three parts, top-level device interface,the core layer and the underlying hardware interface; menuwhile the driver and the device,the top-level device interface and the specific hardware are seperated in operations.


Building maintenance is considered as one of the national agenda. Multitude barriers received by the services providers have undergone various difficulties in satisfying public interest have been progressively resolved as a sign towards becoming a more developed country. In real practice, building maintenance is the thing which we mostly tolerate. If the building is able to weather the elements, we may with delay taking action on it. Most buildings are always treated with 'ad-hoc' maintenance. In some instances, the building disrepair will wait until complaints are made before any repair work is done. It shows that the situation is not considered critical as it may. Maintenance is still being practiced in improper procedure by the maintenance managers which subsequently caused bad impacts to the facilities and the services provided. It can be seen that the managers prefer carrying out reactive maintenance works rather than proactive works and at times do not consider the clients satisfaction and also the performance of services. This paper will focus on some important elements of building maintenance and its relation to building performance holistically.


Jets and fans of dust ejected from discrete emission sources on the sunlit side of comet nuclei were studied. Computer-generated images of these features illustrate the diversity of patterns that can be explained by varying the position of the spin axis, rotation period, location and extent of the active area, and the ejecta's dynamical constants for a given Sun-Earth-comet geometry. It is shown that an emission fan is generated by rotation of a high-latitude source about the spin axis of the nucleus with a relatively high obliquity, but that the fan's formation is rather insensitive to the rotation period. It appears that at least for comets with perihelia well outside the Earth's orbit, the position angle of a fan's observed axis virtually coincides with the projected direction of the spin axis, thus constraining the spatial orientation of the latter.


Abstract : This article specifically addresses the process, problems, and prospects of and for defense transformation in the Asia-Pacific region. Basically, it argues that while several countries there are closely studying and assessing the implications of the emerging revolution in military affairs, they have, for a variety of reasons, made little progress so far in actually transforming their armed forces along its lines. In fact, most countries in the region are unlikely, despite their best efforts, to move beyond "modernization-plus," at least not any time soon. Even this process of innovation, however, could still have many repercussions for regional security and stability, and in ways not currently being contemplated.


Numerical computation is used nearly in all software packages. Today, computation is based on the floating point representation IEEE754 which offers single and double precision while quadruple or extended precision are supported very rarely in current programming languages. In this paper an alternative representation is presented which offers a higher range of digits of a fraction and a higher range of exponents. It is based on the projective extension of the Euclidean space. Due to this representation the division operation can be nearly eliminated, that leads to faster and more robust computation. The presented projective rational arithmetic is especially convenient for vector-vector architectures like GPU.


Hypertrophy is a basic cellular response to a variety of stressors and growth factors, and has been best characterized in myocytes. Pathologic hypertrophy of cardiac myocytes leads to heart failure, a major cause of death and disability in the developed world. Several cytosolic signaling pathways have been identified that transduce prohypertrophic signals, but to date, little work has focused on signaling pathways that might negatively regulate hypertrophy. Herein, we report that glycogen synthase kinase-3β (GSK-3β), a protein kinase previously implicated in processes as diverse as development and tumorigenesis, is inactivated by hypertrophic stimuli via a phosphoinositide 3-kinase–dependent protein kinase that phosphorylates GSK-3β on ser 9. Using adenovirus-mediated gene transfer of GSK-3β containing a ser 9 to alanine mutation, which prevents inactivation by hypertrophic stimuli, we demonstrate that inactivation of GSK-3β is required for cardiomyocytes to undergo hypertrophy. Furthermore, our data suggest that GSK-3β regulates the hypertrophic response, at least in part, by modulating the nuclear/cytoplasmic partitioning of a member of the nuclear factor of activated T cells family of transcription factors. The identification of GSK-3β as a transducer of antihypertrophic signals suggests that novel therapeutic strategies to treat hypertrophic diseases of the heart could be designed that target components of the GSK-3 pathway.


1. An automated method for domain estimation, comprising: receiving a request authoritative name server to resolve a domain name, the server increments the counter for the domain name; ivychislenie index domain attendance on the basis of the counter servers, thus, when calculating the index domain attendance to the counter servers apply a weighting factor determined on the basis of a set of data about the requesting preobrazovateley.2. The method of claim 1, wherein the server is limited to one count of the counter to a specific set of transmitters in a predetermined time interval.3. The method according to claim 2, further comprising a counter increment requests every time you receive a plenipotentiary to resolve the query name server domain name, and the domain index calculation is based on attendance zaprosov.4 counter. The method of claim 1, wherein the weighting factor is based on the geographical location of the requesting preobrazovateley.5 set. The method of claim 1, wherein the weighting is based on at least one level of network traffic and the network traffic type of the requesting preobrazovateley.6 set. The method of claim 1, wherein the weighting factor is based on the architecture of the requesting preobrazovateley.7 set. The method of claim 1, further comprising evaluating whether to initiate a request for resolution of a domain name by the user, and determining the weight coefficient based on said otsenki.8. The method of claim 1, further soderzhaschiyavtomaticheskoe calculating attendance figures domains for a variety of domains serviced by an authorized name server; automatic ranking of the set of n domains


Objective To study the effect of health education on improving the knowledge of occupational health and psychological health status in the workers.Methods 168 workers were asked to fulfill occupational disease knowledge forms and SCL-90 forms before lessons,and repeated it after the lessons of health education.Results 57.14% workers were lack of occupational disease knowledge before lessons,but it changed to be only 2.98% afterwards.Before lessons the sum score of SCL-90 was(193.01±48.43),the maximum factorial score was(2.15±0.83)and the minimal factorial score was(1.99±0.87).After lessons the sum score of the SCL90 was(144.42±28.76),the maximum factorial score was(1.66±0.45)and the minimal factorial score was(1.39±0.42).There were obvious differences between the above indexes of the two groups(P0.01).Conclusion It is concluded that positive effects are observed at the knowledge level on occupational diseases and on the states of psychological health in the workers after health education.


We report progress in the development of InGaN multiple quantum well laser diodes grown by MBE. Lasers were grown by gas‐source MBE using ammonia as the source of nitrogen. Devices were grown on both GaN template substrates with dry‐etched laser facets, and on low dislocation density free‐standing GaN substrates where cleaved laser facets are possible. We have achieved a minimum threshold current density of ∼11 kA cm–2 on templates and ∼7 kA cm–2 on free‐standing GaN. On GaN substrates we have achieved room temperature operation with a pulsed duty cycle of 10%. Further optimisation of the device is required to reduce thermal effects and achieve CW operation. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)


BACKGROUND
The use of remote visual monitoring (RVM) technology as a "telesitter" in hospitals can reduce falls and increase the efficiency of patient observation.

PURPOSE
This study aimed to examine RVM effectiveness as a strategy to decrease patient falls and investigate nurses' acceptance and perceived usefulness of RVM technology.

METHODS
Remote visual monitoring was implemented within a health system in the Southeastern United States. Falls data 6 months prior to and postimplementation were analyzed, and 106 nurses completed a survey evaluating their acceptance of the RVM technology.

RESULTS
There was a significant 39.15% reduction in falls with injury (P = .006), and 70.6% of the RVM redirections were successful. Nurses' acceptance and perceived usefulness of RVM were moderate.

CONCLUSION
Implementing RVM has the potential to enhance patient safety by reducing falls with injuries and is considered acceptable and useful by nurses.


The article focuses on the autobiographies from the most recent edition of "Autobiographies of the Soviet Lithuanian Writers" (Tarybinių lietuvių rašytojų autobiografijos, vol. 1, A–K, vol. 2, L–Ž, 1989) that have been published under different titles every decade (1957, 1967, 1977). Since these autobiographies were typically written specifically for this book, they are dominated by the accounts of the authors' literary career and yet inevitably reflect the writers' attitude towards the dramatic middle of the twentieth century. The author of the article looks at the texts of the Soviet period from a post-Soviet perspective in order to determine how these autobiographies talk about dramatic moments of the twentieth century in Lithuanian history: Soviet occupation in 1940, World War II, 1944–1953 partisan war, and Holocaust. Bearing in mind the writing and publishing conditions of the Soviet times, ideological censorship and censorship in general, it is likely that writers could not express their attitudes freely, nor were they able to objectively identify historical, political and social phenomena associated with the occupation and annexation of the Baltic States and other countries. The term 'Holocaust' started to be used in the Lithuanian language around the year 2000. However, the study reveals that during the Soviet era, Lithuanian authors tried to write about their experiences in their autobiographies within the limits of what was allowed during a difficult historical period. Studies of autobiographies and research on the Soviet mentality and literature provide insight into the efforts of writers of the period to use their personal stories to narrate the events of history that were either concealed from public discourse or deliberately distorted.


The welding experiment of Q245R and Q345R thickness plate was carried out by double wire submerged arc welding. And the welding results were analyzed by macroscopic metallography, microstructure observation and mechanical properties of welded joints. Results show that the double wire submerged arc welding can produce larger penetration, and ensure the weld width. It have better appearance of weld, and the mechanical performance fully meet the requirements of production technology. At the same time, comparison and analysis from the aspects of welding deposition efficiency about the single and double wire submerged arc welding welding process, further illustrates the double wire submerged arc welding can effectively improve the efficiency of welding, reducing welding costs, to meet the requirements of modern industrial manufacture various. It has a good application prospect.


An error-tolerant algorithm in decoding module of Mandarin continuous speech recognition is examined to correct substitution, insertion and deletion errors in acoustic recognition. In order to reduce the computation complexity of the error-tolerant algorithm, two fast algorithms are proposed. In both these algorithms searching space is effectively reduced, and computation efficiency is greatly improved. In the first algorithm only single isolated errors are corrected,and in the other algorithm only errors in keywords are concerned. Experiments carried out in a telephone dialogue system show that by applying the error-tolerant algorithms, word correct rate rises from 78. 97% to 86. 68% , keyword spotting rate rises from 80.56 % to 88.52% , and runtime of algorithm meets the requirement of realtime application.


Research was conducted to test the hypothesis that there is a reciprocal relationship between reading comprehension and oral reading fluency. Previous research indicates that oral reading fluency can aid reading comprehension. However, more recent models have questioned the uni-directionality of this relationship. This research examines this hypothesis by analyzing second grade students' oral reading of connected texts. A summary previewing condition was manipulated in an experiment and the effects on students' passage reading times were evaluated. Grade level students were randomly assigned to one of two groups, an experimental group and a control group. Analyses of Covariance were performed to test the effects of prosodic modeling on oral reading fluency as measured in correct words per minute (CWPM) and prosodic reading, while controlling for students overall achievement in reading as measured by the common state test score. The results showed differences in CWPM indicating the summary preview over the no-preview condition for students at lower levels of fluency performance.


It is fitting that LAP publish an article on Puerto Rico this year. Just over 100 years ago, on July 25,1898, U.S. troops invaded and soon captured the Spanish colony. The Peace of Paris (December 1898) formally awarded Puerto Rico to the United States. No Puerto Rican (or Cuban, or Filipino, or Guamese, and so on) sat at the negotiating table, nor was any consulted, and this boded ill for the future. The following article briefly traces the history of Puerto Rican anticolonial resistance, revealing a long tradition of nationalist and anti-imperialist struggle. Space limitations, however, mean that important topics get shelved. This article does not examine, for example, the massive emigration to the United States starting in the 1920s and 1930s. Traditional historiography explains this exodus in purely economic terms (the spread of large landholdings, the Depression, etc.), but many came because colonial authorities drove them out. Others felt that they could better resist in exile. Still others, like Jesús Colón, the Marxist and American Labor party activist, became politicized in the United States. Nor does the article mention the 15 prisoners of war and political prisoners now serving long sentences in U.S. jails. These men and women (some held in solitary confinement) were punished for defending their homeland against an illegally constituted government. The solidarity movement to free these patriots constitutes an integral part of the tradition of resistance that González-Cruz so amply documents. —Hobart A. Spalding Jr.


Unfortunately many features of software development tools are not accessible by blind users. This forms a major obstacle for them to become professional software developers. On the other hand, many users cannot surpass this obstacle which prevents enough demand to form for tool developers to improve the current situation. Without understanding what accessibility problems there are for blind users, it would not be possible to develop appropriate assistive technologies. With this exploratory study, we investigate the issues blind software developers experience when using software development tools.


Nelson-Barr models solve the strong CP problem based on spontaneous CP violation and generically requires vector-like quarks (VLQs) mixing with standard quarks to transmit the CP violation. We devise an explicit parametrization for the case of two VLQs of either down-type or up-type and quantitatively study several aspects including the hierarchy of the VLQ Yukawas and their irreducible contribution to $\bar{\theta}$. In particular, with the use of the parametrization, we show that a big portion of the parameter space for two up-type VLQs at the TeV scale is still allowed by the constraint on $\bar{\theta}$, although this case had been previously shown to be very restricted based on estimates.


Keck s law successfully predicted the trends for the data rates in optical fibers for four decades. However, in the recent years, it is found that maintaining that trend is very difficult. In this paper, we present and discuss different prospects of the current data rate trends in optical fibers. We analyze Keck's law and its success during the last 40 years. In the later part, we also present its prospects for the future. We show different solutions in sight to stay tuned with Keck's law.


Background: The risk of interne addiction among students from age 18-24 was increasing in many countries now a day. Although the internet is useful tool, internet addiction was associated with physiological and physical problem. The aim of this study was to assess the relationship between level of internet addiction, loneliness, and life satisfaction among Health and Rehabilitation Science. Descriptive correlational design was used to achieve this aim. This study was done by students at Princess Nourah university in Riyadh. Multistage cluster sampling was utilized to determine the size of sample which was 180 female students. Three tools for data collection were used: standardized scales of Internet Addiction Scale (IAS) UCLA Loneliness Scale (ULS) and Satisfaction with Life Scale (SWLS). The result revealed that most of the participants were nonaddicted to internet, had a moderate level of feeling of loneliness that were highly satisfied about their life. Based on this result it was conclude that there is no relationship between internet addiction, loneliness and life satisfaction (p>0.01). It is recommended to broad the population for increasing the generalizability of the results to all Saudi population.


Brazil is a country with one the largest areas of forest plantations in the world. The state of Parana (PR) is in the first of three places of designated plantations areas in the country. The main cultivated species are the genus Eucalyptus. In this work, the areas of better favorability for planting the main species of commercial value eucalyptus were defined. Additionally, changes may also occur in these zones in the coming decades, due to global climate change. For this purpose, future scenarios were elaborated, using stochastic tie series simulation software, verifying the possible changes of the climate and indicating potential consequences regarding the changes of eucalyptus plantation zones. The results show that there will be an increase in areas favorable to the commercial plantations of E. grandis and E. urograndis, species cultivated in Cfa climate (subtropical zones). For E. benthamii, a species cultivated mostly in the Cfb (temperate zones), there will be a reduction of area for use in commercial plantations in Parana, with displacement to areas located to the south and at higher altitudes, where edaphic limitations may occur .


At the beginning of the twentieth century, a new form of work - Private and Special meetings-was tested in the system of interaction of state authorities with the Kazakh population of the Steppe region. Their composition was formed from officials of the administration and branch ministries, representatives of the local ethnic elite to solve socio-economic problems of the traditional Kazakh society. The article presents an analysis of Private and Special meetings based on archival and published sources, some of which are being introduced into scientific circulation for the first time, identifies the range of issues that became the subject of discussion during their conduct and the effectiveness of this mechanism of cooperation between the state and the Kazakh society.


Highly dispersed Ag nanoparticles, stabilized by hyperbranched copolymers (HPCs), were prepared by chemical reduction in toluene. These Ag NPs were used further for the fabrication of a hydrogen peroxide (H2O2) sensor, by which a good catalytic ability for the reduction of H2O2 was found.


This investigation is concerned with the role played by the illusions of security, Bolshevism, and American innocence in the making of the Versailles Treaty of 1919. The main sources used in this thesis were the U.S. State Department publications The World War and The Paris Peace Conference and Paul Mantoux's Proceedings of the Council of Four.
The drafting of the Versailles Treaty is approached chronologically with special emphasis accorded the problems emanating from the questions of Russia and the Rhine. The study concludes that the peacemakers were manipulated by the illusions of security, Bolshevism, and American innocence.


Imatinib mesylate (IM) and other ABL tyrosine kinase inhibitors (TKIs) have had a major impact on early phase CML patient outcomes. However, they are rarely curative and initial and acquired TKI resistance remain challenges. This is attributed to the finding that chronic phase CML stem cells are innately more resistant to IM and other TKIs than the bulk of the more mature cells they generate. To identify differentially expressed and new miRNAs in CD34 + CML stem/progenitor cells that could be potential biomarkers and therapeutic targets, we used Illumina Deep Sequencing to obtain absolute miRNA expression profiles of highly purified CD34 + cells obtained at diagnosis from three CML patients who were classified retrospectively, after IM therapy, as IM-responders and three as IM-nonresponders. CD34 + cells isolated from five normal bone marrow (NBM) samples were similarly analyzed as controls. Bioconductor DESeq analysis revealed 63 differentially expressed miRNAs in the CD34 + cells from CML and NBM samples (P + cells from the IM-responders and nonresponders. Most of the 63 differentially expressed miRNAs identified were present at reduced levels in the CD34 + CML cells as compared to NBM, but 17 were increased. In addition, 34 novel miRNAs were identified in the CD34 + CML stem/progenitor cells. We next validated sequencing data in CD34 + cells from IM-responders (n=12), IM-nonresponders (n=10) and normal individuals (n=11) using a high-throughput quantitative microfluidic device. These studies confirmed the differential expression in CD34 + CML cells of 32 of the 63 identified miRNAs (P + cells from CML patients after three months of nilotinib (NL) treatment (23 normalized after three months of NL treatment, whereas 10 showed little change). To further correlate miRNA profiles with corresponding mRNA expression changes, and to identify potential target genes, RNA-seq was performed on the same RNA samples. Bioconductor RmiR analysis was performed to match miRNA target genes whose expression was inversely correlated with the expression of the deregulated miRNAs based on three of six prediction algorithms ( mirBase , TargetScan , miRanda , tarBase , mirTarget2 , and PicTar ). We identified 1,210 differentially expressed mRNAs that are predicted targets of the deregulated miRNAs in the comparison of CML and NBM data. Strikingly, only seven differentially expressed mRNAs were predicted targets of the deregulated miRNAs identified from a comparison of the IM-responders and nonresponders. Most of these are predicted to have roles in regulation of the cell cycle, MAPK signaling and TGF-beta signaling pathways by DAVID Bioinformatics Resources, which clusters predicted target genes to known KEGG pathways. Thus, aberrant, differentially expressed miRNAs and target genes identified in primitive CML stem/progenitor cells may serve as useful biomarkers to predict clinical response of CML patients to TKI therapy, and may ultimately lead to identification of potential therapeutic targets for improved treatment of CML patients. Disclosures No relevant conflicts of interest to declare.


A simple bis(fluorosulfonyl)imide manufacturing method, with a high reaction rate, characterized in that fluorosulfuric acid and fluorosulfonyl isocyanate are reacted in the presence of one or more salt compounds represented by the chemical formula MX, in which M represents an alkali metal cation, an alkali earth metal cation, or an onium cation, and X represents one of the following anions: F − , Cl − , Br − , I − , SO 4 2 − , FSO 3 − , or (FSO 2 ) 2 N − .


Based on UTAUT2 and the importance of trust to explain user behavior in relation to recommender systems, we focus on job recommender systems by developing and validating a job recommender system acceptance model. The results of our empirical, survey-based study with 440 job seekers indicate that beside performance expectancy and habit, trust is among the three most important determinants and it is especially relevant for women, passive job seekers and those without experience in using job recommender systems. The paper extends general trust and recommender system research by revealing three moderators for the trust and intention relationship. It contextualizes the UTAUT2 by incorporating trust as an antecedent of a consumer's intention to use and by revealing three moderating effects for this relationship. Hence, it is the basis for further studies investigating the acceptance of job recommender system, which has rather been neglected by prior research.


The effect of replacing fish protein with soya protein in tilapia (Oreochromis niloticus) diets was examined. Three isoproteic (35%) diets containing 0% (FD); 50% (MD) and 100% (SD) fish protein substituted by soya protein were formulated. Fish (initial weight = 11.56 ± 4.22 g) was fed with experimental diets for 180 days. Results showed that the best growth was achieved with fish fed FD. Growth parameters such as final body weight, body weight gain and specific growth rate decreased with increased dietary soya protein. In contrast, no significant differences were found in feed and protein utilization parameters. For carcass trait, ash, crude fat, and energy varied significantly with soya protein incorporation in fish diet. Concerning organoleptic characteristics, odour and texture in mouth were not affected by incorporation of soya protein in diet. In contrast, texture, flavour, and general appreciate note were affected by dietary treatment. Partial substitution of fish protein by soya protein gave more pronounced sweet flavour.


Introduction Spring mating of ewe flocks is the traditional husbandry practice in East Griqualand. These flocks lamb during autumn, and are overwintered on pasture or greenfeed. The lambs remain on the green grazing from weaning until October when the herbage quality of the veld is again sufficient to support the nutritional requirements of these animals. Due to the cost of establishing annual pastures an investigation was launched to determine the most suitable irrigated and dryland pasture for autumn born lambs.


In this article the authors introduce a general purpose clock generator based on VXI bus. The clock generator can produce high precision and fine adjustable clock signals.


The Metabolic Syndrome (MS) comprises a constellation of metabolic abnormalities occur together more often than expected by diversity. The MS has its own meaning as it is a predictor of future cardiovascular disease (CVD) actions and diabetes. Aim of this study was to identify the prevalence and risk factors associated with MS among acute coronary syndrome. A total of 100 patients of acute coronary syndrome were examined for metabolic syndrome. MS was identified with application of IDF (international diabetes foundation) criteria and NCEO/ATP III (National cholesterol education program/adult treatment panel-III). History of hypertension, diabetes, drug intake, smoking and alcohol was taken. Relevant general and systemic examination was carried out as per hospital protocol. All patients were subjected to routine investigations like complete haemogram, serum electrolyte, renal, liver and lipid profile. Fasting and postprandial blood sugars were measured according to standard protocol. In resuts the Prevalence of MS was 59% using IDF criteria and 49% with using NCEP-ATPIII criteria. In all patients in both groups presentation of ST elevation myocardial infarction (STEMI) was more common. Sedentary lifestyle was the risk factor for MS, it was also reflected in our study around 70% patients with diagnosis of MS was having sedentary lifestyle. Among the components of MS we found statistically significant difference in FBS, TGL, BP and Waist circumference in patients with MS than without MS. In concusion the Patients with metabolic syndrome had high prevalence of acute coronary syndrome, so lifestyle modification should be undertaken to prevent complications secondary to this syndrome.


Two open reading frames followed by a rho-independent transcription terminator and early promoter were established in a sequenced region downstream from gene 31 of T4 phage. The mRNA hairpin suggested by the terminator sequence has the structure (x)8CUUCGG(y)8, the loop sequence UUCG having been shown to significantly stabilize RNA hairpins.


The European X-ray Free Electron Laser (XFEL) is a research facility and since December 2016 under commissioning at DESY in Hamburg. The XFEL superconducting accelerator is 1.5 km long and contains 96 superconducting accelerator modules. The control system EPICS (Experimental Physics and Industrial Control System) is used to control and operate the XFEL cryogenic system consisting of the XFEL refrigerator, cryogenic distribution systems and the XFEL accelerator. The PROFIBUS fieldbus technology is the key technology of the cryogenic instrumentation and the link to the control system. More than 650 PROFIBUS nodes are implemented in the different parts of the XFEL cryogenic facilities. The presentation will give an overview of PROFIBUS installation in these facilities regarding engineering, possibilities of diagnostics, commissioning and the first operating experience.


The state of India is faced with the challenge of providing basic services, like water, sanitation and energy, to what can be described as "hidden" and "messy" urban populations. Hyderabad is a megacity has been undergoing fast urbanization especially with the cyber turn the city took in 2000s the boundaries between villages, mandals, municipalities have been changing fast and rather randomly. Because data is limited on those "hidden" and "messy" populations, little is known for instance on the Knowledge, attitudes and practice with regard to sanitation and water. This two-minutes video is an illustration of the ground observations of the informal settlements in Hyderabad, India, conducted for the RUST project.


Levy's stochastic area for planar Brownian motion is the difference of two iterated integrals of second rank against its component one-dimen\-sional Brownian motions. Such iterated integrals can be multiplied using the sticky shuffle product determined by the underlying Ito algebra of stochastic differentials. We use combinatorial enumerations that arise from the distributive law in the corresponding Hopf algebra structure to evaluate the moments of Levy's area. These Levy moments are well known to be given essentially by the Euler numbers. This has recently been confirmed in a novel combinatorial approach by Levin and Wildon. Our combinatorial calculations considerably simplify their approach.


The postmodern era poses significant challenges to Christian faith in God. For many, a subterranean question lies just beneath their tenuous faith: "Is there an objective reality upon which faith in God is based?" This essay argues that, in addition to other important factors, a dominant worldview or epistemology within postmodern culture conceals the multidimensional nature of reality and discredits religious faith. Critical realism is introduced as an epistemological framework of both science and theology in which Christian faith makes sense. Significant implications are drawn for teaching and learning and pastoral ministry in Christian congregations.


The present study deals with the visualization of turbulent jet flow from swirl nozzles. A low-cost turbulent jet facility developed was utilized for all the experiments. Two types of vanes are considered for the present study viz. flat vanes and airfoil-shaped vanes. All the vanes are fixed to a circular hollow hub at the center. The flow is visualized by seeding smoke from incense material as tracer particles. A solid-state laser with 405nm wavelength is used for the illumination via a glass rod thereby producing a laser sheet. Cross-sectional visualizations are made at various axial downstream locations. The effect of the vane angle has a greater influence on the production of jet flow vortices due to swirlers. The present study reveals that the increase in the vane angle increases the production of vortices.


FIELD: chemistry. SUBSTANCE: invention relates to chemical industry. Method includes supply of biomass (M, M1) and compressed oxygen-containing regeneration gas (G) into combustion chamber (1), in which continuous process of burning under pressure is supported without addition of external source of oxygen or heat. Ash (A), formed in continuous gasification process, taking place in combustion chamber (1) is removed, and flammable gases are separated together with solid particles. In the process of separation temperature of flammable gas (S) decreases below flashpoint of compounds, contained in flammable gas, as well as below water dew point. Water condensate (W) is removed. From flammable gas (S) liquid fuel (M; M4) is obtained. Regeneration gas (G) is completely or partially directed back into combustion chamber (1). EFFECT: invention makes it possible to provide processing of organic material with positive energy balance. 18 cl, 2 dwg


On the capillary level of intact organs of humans and mammals, fields of gradients of all measurable parameters are found exclusively. Therefore, a precise monitoring e.g. of hemoglobin concentration (Hb) and oxygenation (HbO2) in the microcosm of blood capillaries is only possible when the heterogeneity of tissue data is recorded at a representative number of measuring points. For the collecting of the required data both stochastic or imaging techniques can be applied.


Li Fu, a reconciler of "the similarities and dissimilarities between Zhu and Liu", elucidates this controversial history in his "Zhu Zi Wan Nian Quan Lun" ("The Later Zhu Zi"), which I aim to evaluate and criticize. In my opinion, although Li adopts a reconciliatory position, he sets himself apart by his exhaustive quotations and insightful comments. He distinguishes "the thinkings of Zhu and Liu" from "the critical exchanges between Zhu and Liu" to scrutinize their compatibility. In addition to the attempt to elucidate Li's contribution, I also evaluate "Zhu Zi Wan Nian Quan Lun" ("The Later Zhu Zi") in terms of its contribution and flaws.


Immunohistochemical examination of pulmonary sarcoid lesions from three patients revealed in all the presence of clumps of immunoglobulin and complement in those granulomas which were not completely fibrosed. Similar examination of lung biopsies from 36 patients suffering from a variety of chronic lung diseases but not sarcoidosis showed clumps of immunoglobulin and complement in and around the lesions of only one patient suffering from allergic pulmonary alveolitis. This observation supports the contention that the lesions of sarcoidosis might have an immunologic basis.


HE cariouslike dental lesions induced in the white rat by diets containing large corn or rice particles are inhibited to a marked degree by fluoride,'-iodoacetate, ' 5and penicillin.6-8 These experimental results with fluoride are in agreement with the epidemiological observations of Dean and his co-workers' who ascertained a remarkable correlation between fluoride in communal water supplies, and a reduced prevalence of human dental caries. With regard to the effect of penicillin, Kniesner and Hill'0 observed a marked inhibition of oral lactobacillus acidophilus in young adults using a penicillin dentifrice. The oral lactobacillus acidophilus counts in rats are also reduced by penicillin, together with a notable reduction in caries.6 Much criticism has been directed against the production of lesions in rats' molar teeth by means of a coarse-particle diet which introduces the complicating factor of fractures, and an analogy between experimental rat caries produced by such diets and human dental caries has been questioned, with good reason. It is a primary aim of experimental caries research to produce dental caries in the white rat without the coarse-particle diet complication. Although some success has been achieved in this regard,"1113 variable factors related to diet, prenatal treatment, and the animal 's inherent susceptibility are not yet resolved. The induced form of rat caries, in spite of its uncertain etiology, may serve a useful purpose in classifying other agents besides fluorine, for example, which are suggested as possible dental caries inhibitors or of substances suggested as caries accelerators. In addition to the prospect of finding agents suitable for human caries control, the results may be instrumental in identifying some of the basic reactions of caries etiology. It may be recalled that Miller,1 who first reported the inhibitory effects of fluoride and iodoacetate on induced rat caries, based his interest in these substances on their notable anti-enzymatic properties. The inhibitory effects of these two substances are suggestive of a role of glycolysis through the phosphorylation. mechanism in caries etiology. Specific inhibitors of glycolysis or of other enzyme systems having been identified with experimental caries, may be found later to seek a similar target in the human organism.


We study the performance of single- and double- THick Gas Electron Multiplier (THGEM) detectors in pure Hydrogen (H2) and Deuterium (D2) at low pressures, in the range of 100–450 torr. The effect of the pressure on the maximum achievable gain, ion-back flow and long-term gain stability are investigated for single and double cascade detectors. In particular, it was found that maximum achievable gains above 104, from single-photoelectrons avalanche, can be achieved for pressures of 200 torr and above; for lower pressure the gains are limited by avalanche-induced secondary effects to a values of around 103. The results of this work are relevant in the field of avalanche mechanism in low-pressure, low-mass noble gases, in particular for applications of THGEM end-cap readout for active-target Time Projection Chambers (TPC) in the field of nuclear physics and nuclear astrophysics.


These practical questions mirror a sentiment especially popular in the United States: international law does not count as law because it cannot be enforced. Many lawyers as well as the general public are skeptical about international law, and the media's obsession with sanctions is ubiquitous. When North Korea fires rockets over Japan or Iran continues developing nuclear weapon capabilities, the first likely question is "What sanctions will be imposed?"


People's lives are still greatly impacted by the novel coronavirus outbreak, which has no effective treatment; however, the SARS virus two decades ago quickly disappeared. The study aims to find out how the SARS virus spreads, and also compares the SARS virus to the novel coronavirus. In the whole study, the author used the SIR model and the SEIRP model. It also combines specific cases of specific cities. Finally, through analysis, it is found that the epidemic of COVID-19 can be defeated by mass immunization and improving medical treatment. And how to prevent the spread of novel coronavirus.


To analyze the fund management compensation incentive and restraint mechanism,it empirically examed the relationship between the equity open-end fund management compensation and performance based on the static panel data model.The results show that fund management compensation incentive and restraint mechanism in China is not working effectively.So it made some improvements to existing contract using the principal-agent theory.It introduced excess return which reflects managers' effort level to measure fund performance,and designed a mixed management compensation contract which combines the fixed fees with floating compensation.In the last,it verifies the superiority of the mixed one in promoting fund managers work harder by comparing fund managers optimal effort level of the two contracts in the same pay cost.


COVID-19 pandemic has impacted all aspects of our lives including learning. With the particular growth of e-learning, teaching approaches are being implemented at a distance on online platforms due to this pandemic. In this context, to make student involved throughout the online course, it is recommended to create an efficient platform similar to the traditional learning mode.  In this study, we aims to improve learning style detection process by exploring additional such as cognitive traits. In fact, we have proposed novel approach based on Artificial neural network that classify students according to their level of cognitive learning styles in real-time. The proposed automated approach will certainly provide tutors with exhaustive information that helps them in achieving an improved and innovative online learning method. The results obtained are quite interesting and demonstrate the relevance of our solution.


Abstract Binding of drugs to serum albumin is one of the most important pharmacokinetic determinants and the design of drugs should take advantage of this property. In the present work, the fluorescent ligands Warfarin and dansylsulfonamide were used as probes of IIA site of human albumin and dansylsarcosine as the probe of the IIIA site. From the changes in fluorescence upon binding at 37°C, pH 7.4, the following dissociation constants were determined: Warfarin, 3.43 ± 0.69 μM; dansylsulfonamide, 7.57 ± 0.88 μM; and dansylsarcosine, 6.06 ± 1.09 μM. Nonfluorescent ligands displace these probes competitively and the type of probe displaced identifies the site specificity of the ligands. Nonlinear least-squares analysis of the decrease in fluorescence accompanying the displacement yields the stoichiometry and the dissociation constants. The dissociation constant may also be estimated rapidly from displacement at a single competitor concentration. The method yields reliable K d values for at least the range of 0.2 to 100 μM. Representative dissociation constants for the IIA site-specific ligands are as follows: phenylbutazone, 1.9 ± 0.3 μM; U-99,499, 1.8 ± 0.2 μM; U-96,988, 5.3 ± 1.5 μM; and U-105,665, 42 ± 7 μM. For the IIIA site we find the following K d values: oxazepam, 27.7 ± 2.1 μM; diazepam, 7.7 ± 1.0 μM; and ibuprofen, 2.7 ± 1.2 μM. The method is eminently suitable for large-scale screening.


This study aims to determine and empirically test the effect of providing information and outreach, educationalbackground and business scale on the understanding of MSMEs in preparing financial reports based on SAK ETAPat MSMEs Tembilahan District, Indragiri Hilir Regency, Riau. The sample of this study were 63 MSMEs in thegold, cellphone, drug and electronic trading sectors in Tembilahan District, Indragiri Hilir Riau District. Datacollection techniques used the Surver Method. This study uses the data analysis method of Multiple LinearRegression using SPSS Version 26. Partial hypothesis test results show that the provision of information andsocialization have no effect on MSME understanding in preparing financial reports based on SAK ETAP onMSMEs Tembilahan District, Indragiri Hilir Riau District, educational background influences the understanding ofMSMEs in preparing financial reports based on SAK ETAP at UMKM Tembilahan District, Indragiri Hilir RiauDistrict, and the business scale influences the understanding of MSMEs in preparing financial reports based on SAKETAP on MSMEs Tembilahan District, Indragiri Hilir Riau Regency. Hypothesis test results simultaneouslyproviding information and outreach, educational background and business scale simultaneously affect theunderstanding of MSMEs in preparing financial reports based on SAK ETAP at MSMEs Tembilahan District,Indragiri Hilir Regency, Riau. The coefficient of determination of 43.8% shows that the understanding of MSMEs inpreparing financial reports based on SAK ETAP at MSMEs Tembilahan District, Indragiri Hilir Riau District isinfluenced by the provision of information and socialization, educational background and business scale of 43.8%,while the remaining 56 , 2% is influenced by other variables not examined in this study.


The author evaluates the quality of 5-year and 10-year demographic projections by comparing the projected population of 8 departments in the Midi-Pyrenes region of France over the period 1821-1976 with the actual population as derived from census data for the same period. Projections were done for 5 and 10 years using first the figures of the total population and then the logarithms of those figures. For 5-year projections the best results were obtained by observing 2 preceding censuses or a 9-year period and the worst results by observing data from 5 preceding censuses; results were more accurate if computations were made with the logarithms of the figures but they did not change the description of the evaluation. For 10-year projections the best results were obtained with observations of the 3 preceding censuses or a 10-year period. Again results obtained with logarithms were more accurate.


Biotechnology is the important component of national strategic high-technology,it has become a world-wide strategic development emphasis.This paper figures out the patent datum related to Biotechnology granted by USPTO and analyzes the overall out-put and technology focus at Biotechnology in terms of related patent number as well as its annual change,lifecycle,assignees,inventors,International Patent Classification.This paper also deeply analyzes the development and strategic layout of main countries at Biotechnology according to the amount of patent.