Discussions about forced migration in Colombia have limited the study to the analysis of individual variables without considering the common elements in these variables. The Factorial Analysis helps to better identify the causes of migration by allowing disaggregate the study variables in factors associated with government policy. To develop this document dimensional scaling was used by Factorial analysis using decision criteria associated Bayesian approach. A model solved by Generalized Least Squares order to identify early relationships between the identified factors is proposed. It was found that using the Bayesian approach the number of common factors change from the traditional approach. The use of Bayesian models for the second phase of this study is required.


The article substantiates the need for a full-fledged assessment of the effectiveness of the investment project, consisting not only of the analysis of standard indicators of project efficiency (NPV, DPP, IRR), but also the analysis of the risks of projects. In addition, the analysis and risk assessment of the investment project of the organization, the ways to improve the effectiveness of risk assessment methods of the investment project are proposed. The purpose of this work is to analyze and assess the risks of the investment project of the organization. To conduct the study the following methods were used: classification, analysis, comparison, modeling and forecasting. The work performed showed that the use of only one method for risk assessment is considered ineffective, since only different combinations of methods for analyzing the risks of an investment project can give a complete picture of the weaknesses and strengths of the project, as well as assess its effectiveness in case of changes in any external conditions.


The extensively used bag filteris manipulated by Panasonic programmable logic controller of FP1-C40,which has stable and reliable features,with stronger anti-interference ability and lower cost.This paper presents a detailed introduction of the hardware of this system,as well as the realization of pulse iet control srstem and the program of ladder diagram.It also makes an analysis of the common faults of PLC.


Abstract The experimental results leading to information about the level structure of nuclei with A=97 have been compiled and evaluated. These include the results of all experiments studying the decays within the mass chain as well as the reactions leading to nuclei with A=97. The compiled information is presented as data sets for the individual experiments. Based on all the relevant data sets, tables of adopted levels and γ radiations are then produced for each nucleus. This compilation replaces parts of "Nuclear Data Sheets for A=97" published in vol.46, p.607 (1985).


Critical Phenomena: a Reminder.- Conformal Invariance and the Stress-Energy Tensor.- Finite Size Scaling.- Representation Theory of the Virasoro Algebra.- Operator Algebra and Correlation Functions.- The Ising Model Correlation Functions.- Coulomb Gas Realization.- The Hamiltonian Limit and Universality.- Numerical Techniques.- Conformal Invariance in the Ising Quantum Chain.- Modular Invariance.- Further Developments and Applications.- Conformal Perturbation Theory.- The Vicinity of the Critical Point.- Surface Critical Phenomena.- Outlook: Beyond the Conformal Group.


As we now look to move up the stack with SiPs (system in packages), micromodules, and modules, you the customer are once again presenting us with new and novel measurement challenges; challenges that will force us to refine our measurement methodology and develop novel test and measurement solutions. SiPs leverage complex core technology and go to an unprecedented level of system integration by incorporating passive and active components alongside, in some cases, a central processing unit for configuration and control. This level of integration introduces ever increasing functionality, embedded feature sets, advanced packaging, internal node access issues, embedded software, and system-level calibration to name a few. These solutions simplify the user experience of our complex converter products; but the complexity is handled and the design and measurement barriers are overcome within ADI.


The authors propose a bifilar helical antenna with a self-complementary shape. Bifilar helical antennas having an omnidirectional radiation pattern often have been composed of thin wires . In these conventional shapes, it is difficult to design an antenna satisfying both desired characteristics of the radiation and the reflection because the design parameters, such as antenna diameter, simultaneously influence these characteristics. The proposed antenna has an input impedance of which the conductance is almost constant by applying a self-complementary shape to the antenna structure. This technique allows selection of the optimal antenna diameter for the radiation characteristic independent of its impedance matching.


As an invited contributor to Arts Education Policy Review, I am pleased to have this opportunity to address a readership directly concerned with educational policy. But I have the mark of the interloper. As a university instructor for more than thirty years, I have some knowledge of education, but it does not extend to preschool and K-12. Nor have I expertise as a practitioner in the arts or as a teacher in arts education. My background is in experimental psychology and the physiology of the nervous system. More specifically, my own laboratory is concerned with the questions of how learning takes place in the brain and how the brain makes memories. The fact that I study mainly the auditory cortex (the highest level of the auditory system) brought me into contact with some of the research literature on music, and I have done some research on the neurophysiology of music.


Abstract Like many scientific topics, Human Factors, and Ergonomics concepts are susceptible to being misunderstood by people unfamiliar with the subject matter. Most of the time these misunderstandings are harmless, like when a safety poster within a work setting encourages employees to 'overcome complacency'. This misunderstanding of complacency suggests it is a motivational aspect of human behaviour correctable with encouragement, whereas the human factors approach to overcoming complacency would be to evaluate how task design could diminish the destructive consequences of unexpected changes within a routine setting. No harm comes from the message within the safety poster, other than some wasted ink and paper, but misconceptions among particular audiences can eventually result in dire consequences for the human operator. This paper presents recent evidence that the concepts are being misapplied by casual consumers of human factors, particularly in the aftermath of accidents within complex systems, in ways detrimental to the core mission of improving the well-being of the human operator. Later, because this special issue presents new ways to demonstrate value via return on investment, practical efforts we can take to overcome such misconceptions are suggested.


Objective To study the relationship between plasma homocysteine(Hcy) and lower extremity atherosclerotic disease(LEAD) in the elderly patients.Methods A total of 217 elderly patients were selected in sequence,which were divided into normal group and lower extremity atherosclerotic disease(LEAD) group according to the ankle-brachial index(ABI).The medical history including smoking,hypertension,diabetes,hyperlipidemia,coronary heart disease and stroke was recorded.The biochemical indicators including Hcy,creatinine(Cr),uric acid(UA),cystatin C(Cys-C),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C) and blood pressure(BP),body mass index(BMI),abdominal circumference were collected.And laboratory parameters in each group were retrospectively analyzed using multiple regression analysis.Results The age,gender,abdominal circumference,BMI,diastolic blood pressure(DBP),Cr,Cys-C,fasting blood glucose(FBG),TC,TG,LDL-C and the history of high blood pressure,diabetes,hyperlipidemia of the two groups were no significantly difference(P 0.05).Hcy,UA,systolic blood pressure(SBP) and pulse pressure(PP) were significantly higher in the LEAD group than those in the normal group(P 0.05).And there were significantly more patients who had the history of smoking,coronary heart disease or stroke in the LEAD group(P 0.05).ABI and HDL-C were significantly lower in the LEAD group than those in the normal group(P 0.05).Multiple regression analysis showed that Hcy was positively associated with LEAD(P 0.05).Conclusions The high hyperhomocysteinemia(HH) is an important risk factor of cardiovascular disease,which should be intervened actively.


This paper is concerned with a numerical study of steady fully developed second-grade flows in a curved pipe of circular cross-section and arbitrary curvature ratio, driven by a pressure drop. The qualitative behaviour of the secondary flows is analyzed with respect to inertia and viscoelasticity effects.


This study examines the effects of media produced constructions of Black masculinity and crime on Toronto's diverse African communities. Nineteen individuals, living in the areas of Downtown Toronto, Etobicoke, North York, Scarborough and East York, were interviewed about their experiences with the racialization of crime in the print and visual media. Interview discussions revolved around the welcome of immigrants of African descent, depictions of Black males, media coverage of crime according to the ethnicity of the assailant and victim and parental concerns of how their children are viewed by society. A second group of issues discussed is intra-group conflict and confidence in the Canadian criminal justice system. The final group of issues discussed is the deportation of Black male immigrants and racial profiling. Participants demonstrated beliefs that their lives had been negatively affected by this phenomenon. Lack of concern about depictions of Black men and the internalization of images by Black children and adults, were cited as struggles. Participants also admitted to intragroup conflict as a result of depictions of Jamaicans as well as lack of confidence in the criminal justice system. Finally, respondents expressed beliefs that deportations disproportionately affect Black individuals and that racial profiling is a prevalent problem. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.


The Casimir Force was predicted in 1948 by Dutch physicist Hendrick Casimir. Casimir realized that when calculating the energy between two parallel uncharged conducting plates, only those virtual photons whose wavelengths fit an integral number of times into the gap should be counted. Each mode contributes to a pressure on the plates, and the infinite number of modes outside the plates is in some sense greater than the infinite number inside the plates, resulting in a small force drawing the plates together. This experimentally-confirmed force is one observable consequence of the existence of the vacuum electromagnetic field.


A field experiment was conducted to find the effect of different sources and levels of sulphur on yield and quality of cauliflower (Brassica oleracea) under temperate conditions of Kashmir. The experiment was laid out in randomized block design with three sources of sulphur, viz. elemental sulphur, gypsum and single superphosphate (SSP) and replicated thrice. The plots were given uniform dose of NPK (100:120:60 kg/ha). Gypsum recorded highest plant height, days to maturity, yield attributes and yield as compared to elemental sulphur and SSP; whereas, among the different levels of sulphur, 45 kg S/ha recorded highest value of plant height, days to maturity and yield attributes and yield. Among the quality parameters, ascorbic acid, protein content in curd was significantly higher with application of Gypsum and 45 kg S ha-1, whereas, free nitrate (NO-3) content was significantly lower in SSP (a desirable quality).


Mathematic models of the normal grinding force and the tangential force during external cylindrical traverse grinding are built in.Simulation is finished by Mathlab 6.0,and experiment is performed on the modified MMB1320 semiautomatic grinding machine.Simulation and experiment results are validated and this verifies that the built mathematic models of force during external cylindrical traverse grinding are applicable.


The article presents the results of a theoretical analysis of the literature, which showed the presence of a significant number of gender biases in scientific research of the last century. Modern research, on the contrary, shows a tendency to rethink established gender stereotypes and move away from neurosexism. The desire of modern scientists to create science beyond gender stereotypes is growing. It is emphasized that in Ukraine, there is a tradition of research on gender issues. It is noted that today there is an insufficient number of psychodiagnostic tools in the Ukrainian language, which can be used to study the gender beliefs of an individual. The article aims to present the adaptation of the English-language questionnaire "Gender Bias Quiz" into Ukrainian. Research methods are: system-structural analysis, generalization of scientific literature data to the requirements of adapting the psychodiagnostic tool and evaluating its reliability, methods of mathematical statistics (Cronbach's Alpha criterion and Pearson correlation coefficient). The reliability assessment of the "Gender Bias Quiz" questionnaire included an assessment of internal consistency and retest reliability. The procedure for adapting the psychodiagnostic tool met the necessary criteria: sufficient sample size for this type of questionnaire (n=52), representativeness of the sample (adolescence students), the required time interval between the first testing and the second one (1 month). The sample consisted of 52 students aged 17 to 24 years (M=21, SD=1.71). The results of checking the questionnaire`s reliability based on the internal consistency indicator using Cronbach's α showed its sufficient level (α=0.87).Retest reliability was checked by calculating the correlation coefficient between the results of the first test (M=39.83; SD=10.2) and the repeated test (M=39.29; SD=11.9). The correlation analysis performed showed a significant level of correlation (r=0.89 at p≤0.001), which indicates fairly high retest reliability of the psychodiagnostic tool. For the correct use of this questionnaire, some limitations were outlined: 1) the adaptation of the methodology took place on students, so it can be used in the study of gender attitudes of youth personality; application on representatives of other age categories requires an additional adaptation procedure; 2) this questionnaire does not belong to standardized psychological methods but is actually a questionnaire that studies the respondent's opinion on the gender issue; therefore, the definition of statistical norms based on the results obtained from this questionnaire is not correct in this case. It should be noted that the application of this questionnaire has significant potential in cross-cultural comparisons of gender biases of representatives of different countries and regions. The results of the questionnaire adaptation procedure showed a sufficient level of reliability of the questionnaire and confirmed the possibility of using it as a psychodiagnostic tool for studying the gender attitudes of a young person. We see the prospect of further research in expanding the boundaries of using the questionnaire: adaptation to other age categories of respondents.


1. Short-term (days) hydrodynamic effects of wind-induced mixing on phytoplankton size structure, and C and N uptake characteristics, were studied in the surface mixed layer (epilimnion) of Lake Biwa (North Basin), before and during a period of high winds (typhoons).

2. The latter period was characterized by two major typhoon events associated with deepening of the seasonal thermocline, reduced water column stability, decreased underwater irradiance and increased dissolved reactive N and particulate P.

3. Nutrient concentrations, seston C/N ratios, and uptake rates indicated that phytoplankton biomass and production were limited by P and not N throughout the study. Higher C- and N-based productivity during the typhoon period than before reflected the increased phytoplankton biomass and higher specific uptake rates due to increased nutrient supply.

4. Changes in the size-structure of phytoplankton ( 2 μm) were associated with variations in the stratification and mixing regime. When vertical stability was high (before the typhoons) concentrations of > 2 μm biomass (chlorophyll a, particulate organic C and N) were higher at the bottom of the mixed layer than at the surface whereas, when stability of the mixed layer was low (the typhoon period), the contribution of picoplankton (< 2 μm) to total Chl a increased at the surface and decreased at the bottom following the first high winds.

5. Photoadaptive adjustments of the phytoplankton provided further evidence of hydrodynamic control. The lower intracellular Chl a concentrations and C and N uptake efficiencies in the < 2 μm fraction suggest that they experienced, on average, higher irradiance than the larger cells because of their lower sinking rates. During the stability period, picoplankton exhibited higher photosynthetic efficiencies at the bottom of the mixed layer than at the surface. Such differences disappeared during the typhoon period indicating that the mixing rate was then probably higher than the photoacclimation rate in the small size fraction.

6. The present results stress the highly transient nature of biological homogeneity in the surface mixed layer of the lake.


On the basis of experiment,the influence of impressed electromagnetic field on fire transmission speed and overpressure in gas explosion was investigated.The research result shows that the influence of impressed electromagnetic field strengthen the gas explosion,and make the flame propagation speed,the flame propagation speed peak value and the overpressure peak value enlarged;with the increase of electromagnetic field intensity,the effects on aggravating the gas explosion raise.And the influence of impressed electromagnetic field on gas explosion was analyzed.


AMENORRHEA is one of the most consistent and usually one of the earliest symptoms of pituitary tumor in women. Menstrual function may return, however, even after a prolonged period of amenorrhea, following surgical removal of the tumor, its shrinkage by roentgen irradiation, or possibly in rare instances following the escape of the expanding tumor from the sella turcica with consequent decompression of the normal elements of the gland. In the following unique case resumption of uterine bleeding occurred in an acromegalic as the result of a coincidental lesion, namely, a granulosa cell tumor of the ovary. Case report.—The patient was a 42-year-old white, married, Russian-born housewife, who was first seen at the Columbia-Presbyterian Medical Center September 16, 1948, with the complaint of enlargement of the hands and feet and distortion of the face. These symptoms, first observed by the patient about six years before, had been preceded for about three years by excessive fatigue and frequent blurring of vi...


Electronic imaging systems transfer views of real-world scenes or objects into digital bits for storage, manipulation, and viewing. In the area of bitonal images, a large market exists in document management, which consists of scanning volumes of papers for storage and retrieval. However, high scan densities produce huge volumes of data, requiring compression and decompression techniques to preserve system memory and improve system throughput. These techniques, as well as general image processing algorithms, are compute-intensive and require high memory bandwidth. To address the memory issues, and to achieve interactive image display performance, Digital has designed a series of bitonal image hardware accelerators. The intent was to create interactive media view stations, with imaging applications alongside other applications. In addition to achieving memory, performance, and versatility goals, the hardware accelerators have significantly improved final image legibility. [Accelerators paper starts here.]


In this paper, we consider the problem of computing numerical solutions for stochastic differential equations (SDEs) of Ito form. A fully explicit method, the split-step forward Milstein (SSFM) method, is constructed for solving SDEs. It is proved that the SSFM method is convergent with strong order gamma = 1 in the mean-square sense. The analysis of stability shows that the mean-square stability properties of the method proposed in this paper are an improvement on the mean-square stability properties of the Milstein method and three stage Milstein methods.


The article shows the principles of systematization of plots of the mythological subject "Mythic Wife". It analyzes principles applied by K.V. Yadanova, the author of recently published index of the Altaic mythological prose in comparison with the already existing index made by the article author. The role of the systematic index of plots in determination of ethnic specifics of forms against a wide international context is shown.


It has been suggested that field data cannot be used for estimation of POD because of the bias caused by ignoring the fact that some flaws are missed in inspections. The use of a regression model that allows for truncated data can, however, provide estimates that do not have serious bias. In this paper we use Monte Carlo simulation to assess the effects of misses in the estimation of POD and to study the properties of estimates that one obtains by using the truncated data regression model.


The letters of Pliny the Younger (c. 61 c. 112 CE), a polished social document of his times, include descriptions of the eruption of Vesuvius in 79 CE and the earliest pagan accounts of Christians. The Panegyricus is an expanded, published version of Pliny s oration of thanks to the Emperor Trajan in 100 CE.


Abstract Absorption and emission spectroscopy in the ultraviolet and visible regions, apart from being the earliest physical techniques of analysis, have great utility in solving a variety of structural and analytical problems [l-41. However, in many cases the quantitative determination of individual components in a mixture by UV-VIS spectroscopy becomes very difficult owing to the spectral similarities and overlapping of weak absorption bands of one component by strong absorption bands of other components. It was recently recognized that derivative spectrophotometry, introduced about three decades ago [5-81 and originally proposed by Rutherford [9], can be a very useful analytical tool for characterizing an analyte band that is overlapped by other absorption bands with different halfwidths. On differentiation, the intensity of the absorption band with a small halfwidth increases more than that of a band with a large halfwidth [10]. The central idea behind the development of the science of derivatized spe...


Measurements of neutron total cross sections are both extensive and extremely accurate. Although they should place a strong constraint on theoretically constructed optical models, there are relatively few comparisons of optical model predictions with those experiments. We have calculated total cross sections for neutron scattering from {sup 40}Ca as a function of energy from 100 - 600 MeV laboratory energy with a microscopic first order optical potential derived within the framework of the Watson expansion. Although the results are already in qualitative agreement with the data, the inclusion of medium corrections to the propagator using a recently derived microscopic mean field approach, is essential for correctly predicting the energy dependence given by the experiment. In the region below 200 MeV, where our off-shell tp calculations over predict the experiment, the modification due to the nuclear medium reduces the calculated values, whereas above 200 MeV, these corrections tend to compensate for the under prediction of the off-shell t{rho} results.


Problem. The purpose of this study was to determine the perceived impact of collective bargaining on the functional role of the public high-school principal in Michigan. The study focused on the perceptions of practicing educators in Michigan. Perceptions were sought from superintendents, principals, and teachers in K-12 public school-districts. Data Collection, Methods, and Procedures. Data were collected by means of a mailed questionnaire from a sample of the 529 K-12 public-school districts in Michigan. Power analysis helped determine that 106 school districts were needed to have a significant study. Replies were received from 100 of the 106 districts for a return rate of approximately 94 percent. The survey was completed in June 1982. The data were analyzed by use of a computer to determine statistical significance. The chi-square test of analysis was used to determine statistical significance. Major Findings. There is a significant difference among the perceptions of superintendents, principals, and teachers on the perceived impact of collective bargaining on the functional role of the public high-school principal in Michigan. The superintendents perceived three (Instructional, Personnel, and Pupil services) of the five subcomponent roles to be statistically significant. The principals perceived one (Pupil services) of the five subcomponent roles to be statistically significant. The teachers perceived two (Instructional and Professional relations) of the five subcomponent roles to be statistically significant. All responding groups perceived the Community relations role to be statistically nonsignificant. The sponsorship of extracurricular activities was the item perceived as most affected by collective bargaining. Conclusions. Superintendents and teachers perceived the impact of collective bargaining on the principal to be greater than did the principals. The greatest impact was made on the Personnel role. The least impact was made on the Community-relations role. It appeared that the effect of contract implementation was considerable. Analyzation of questionnaire items showed the superintendent-principal group to be the most alike in their perceptions. Further analyzation showed the principal-teacher group to be the least alike in their perceptions. The most change was perceived by the superintendents. The least change was perceived by the principals.


Abstract In this era of industrial revolution (IR 4.0), coupled with the emergence of the deadly global pandemic of COVID-19, healthcare organizations are compelled to embrace new technologies for their routine decision-making. The Business Intelligence System (BIS) is one of the emphasized innovations, and due to its potential to provide more intellectual information for decision-making processes, has attracted the interest of industry analysts and policymakers. Literature suggests that the BIS is integrated by organizations in different sectors, but most BIS initiatives struggle to produce the anticipated outcomes. Moreover, the adoption of BIS in SMEs generally and healthcare specifically is rather insignificant. This is due to numerous factors. It is therefore necessary to discover and analyze the essential determinants affecting the adoption of BIS in healthcare SMEs. Therefore, this study tries to tackle this gap by exploring the relevant factors for BIS adoption using a systematic literature review (SLR) and an expert-ranking survey of 63 studies that were published in Scopus and WoS databases from 2011 to 2020. A total of 22 determinants are identified and sent to 15 experts. The data that were gathered from these experts were analyzed using SPSS. The results of the analysis indicated 15 determinants were significant, and one determinant was added by an expert. Consequently, a theoretical structure has been developed based on technology, organization, environment, and CEOs determinants and theories. The results of the current study will deepen the current BIS literature and advance the understanding of the significant elements of BIS adoption decision.


The main objective of the study is to provide a model that will show the relationship among teaching performance, job satisfaction and resiliency of faculty members. Questions like what factors bring about the resiliency of the faculty, factors that make them satisfied with their work and factors that make them perform well are thoughts that need to be translated into grounded facts. The relationship among these three variables was scrutinised to define if relationship in teacher's performance, resilience quotient, and job satisfaction is significant or not. A descriptive-correlational research approach was employed using purposive sampling technique of 303 faculty members from a state university in the Philippines. The Job Satisfaction Survey Tool (JSS) (Spector, 1994), Resiliency Quotient (RQ) (Russell, 2006), and the Teaching Performance Evaluation tool (NBC 461, 1998) were used as questionnaires for collecting data. Results show (1) "very satisfactory" teaching performance rating; (2) faculty members are satisfied with their job in terms of: nature of work, supervision, co-workers, communication, and pay; (3) faculty members are "highly resilient" ; (4) significant relationships in the teaching performance, job satisfaction and resiliency quotient of faculty members exist from moderate to very high correlation. Conclusion can be drawn that faculty members with higher level of job satisfaction and high teaching performance evaluation would have higher level of resilience.


Structural features of the Al-Pd-Mn decagonal quasicrystal were studied by high-resolution transmission electron microscopy. The structure of the decagonal quasicrystal may be interpreted as a tiling using three types of tiles, such as a decagon, a star-shaped pentagon and a squashed hexagon. The arrangement of the decagonal atom clusters has long-range correlations, in which they are arrayed on straight lines parallel to the ten-fold directions


SUMMARY Objective. To know the frequency rate of chickenpox in pregnancy women attended in the hospital and the frequency of transmission to the newborns, complications and mortality. Material and methods. The hospital files in between 1992-2002 were reviewed. Twenty pregnant women with varicella and its 22 neonates were studied. Data about the clinical disease, its evolution, complications and treatment was obtained. Results. The frequency rate, in relation to 53,500 pregnant women attended was 3.7/10,000; eight newborns developed neonatal chickenpox; there were not cases of congenital infection; two of children with perinatal varicella had complications, (skin infection and sepsis), one child was dead. Seven of the 8 children with neonatal varicella received treatment with aciclovir, and five further received human gammaglobulin. Conclusions. The women with chickenpox is the same of the rate reported in the literature.


A review on the recent progress and the future prospects of analytical methods for the determination of iodine,either present naturally or added artificially in foodstuffs,was presented,covering mainly the years from 1988 to 2007,including chemical analysis,molecular spectrometry,atomic spectrometry,electrochemical methods,chromatography,mass spectrometry and neutron activation methods(80 ref.cited).


With the deepening of the structural reform of higher education, the intermediary bodies for university have become an important form in the reform and development of higher education. In view of their nature, function and manifestation form, different intermediary bodies for university, though they look similar, adopt different organizational behavior since they are based on different theories. To put it briefly, the intermediary bodies for university in various countries of the world can be divided into three types, namely, buffer type at the early stage, middle institution type at a later stage, and the great number of "intermediary body" type based on information asymmetry in the present time.


To ensure sustainable populations of native animals and plants, managers of protected areas must understand carrying capacity of large wild herbivores. Estimates of carrying capacity and how large herbivores may influence native vegetation require knowledge of their activity and foraging patterns. Therefore, we examined activity patterns and foraging behavior of adult male moose ( Alces alces shirasi ) in Rocky Mountain National Park, Colorado by following individual animals and counting bites during the summer and fall of 2003 and 2004. Mean active time per day peaked in late June at 11.3 h and declined to 8.9 h in early fall preceding the breeding season. Moose averaged 6.7 feeding periods/d, each lasting 79 min; feeding bouts were longer around sunrise and sunset and were shorter midday presumably because of high ambient temperature. Activities associated with feeding and resting constituted 94.0% of daily time budgets. Feeding declined and social behavior and movement increased in fall with the onset of the breeding season. Food consumption increased steadily through early summer peaking at 126.8 g/kg BW0.75 in early August, followed by a sharp decline to a low of 69.1 g/kg BW0.75 in early September. Daily digestible energy intake was estimated at 1191 kJ/kg BW0.75/d. Maximum rates of instantaneous intake were recorded in early August at 22.3 g/min. Because intake rates of willow ( Salix spp.) increased from June-August, but nutritional quality peaked in mid-June, increases in daily and instantaneous intake rates during summer seemed more related to forage availability than protein and energy content of willow leaves. The nutritional carrying capacity of summer range in Rocky Mountain National Park in 2004 was estimated from the range supply of metabolizable energy, digestible energy, and available nitrogen. Based on the digestible energy intake and energy requirements of a 344 kg male moose, the summer range carrying capacity was estimated at 0.21 moose/km2. Nitrogen based estimates were considerably higher at 0.32 moose/km2.


Cellular responses to DNA damage are highly variable and strongly depend on the cellular and organismic context. Studying the DNA damage response is crucial for a better understanding of cancer formation and ageing as well as genotoxic stress-induced cancer therapy. To do justice to the multifaceted cellular changes, elicited by DNA damage, use of high-throughput techniques and integration with bioinformatics tools is of great value.
This thesis summarizes recent advances in the field of systems biology studies of the DNA damage response and furthermore shows integrated approaches of the study of DNA damage response signaling networks in embryonic stem and cancer cells. By integration of transcriptional changes and the phosphorylation and metabolic response of cisplatin-treated embryonic stem cells, with RNAi-based knockdown screens we identify novel DNA damage response signaling networks, linking process such as Wnt signaling, translation arrest or altered metabolic pathways to the cellular response to DNA damage. Furthermore, genes, whose knockdown sensitizes embryonic stem cells to DNA damage-induced killing, are tested in cancer cells of varying genetic backgrounds identifying a small subset of genes, which represent potential drug targets for sensitization of cancer cells. Altogether, our systems approach for studying the DNA damage response identifies novel DNA damage-induced signaling networks and molecules, which modulate survival in the presence of DNA damage, potentially providing new targets for therapeutic intervention or biomarker discovery.


A low-voltage arc fault detection method comprises collecting current signals in a loop through a current sensor, obtaining fundamental frequency analog signals and high frequency analog signals, achieving accumulating calculation of the fundamental frequency analog signals and high frequency analog signals of power frequency cycle through an integrating circuit, an interrupt trigger and a timer, and further obtaining higher harmonic occupancy. According to the method, whether arc faults occur is judged by real-time monitoring of change characteristics of the line current higher harmonic occupancy and calculation of over-limit times of the higher harmonic occupancy, normal arc and fault arc which are generated by some special electric appliance loads and normal on-off action are distinguished by judging whether higher harmonic occupancy changes caused by the arc faults are periodic and judging occurring frequency, occurrence of the arc faults can be detected in real time, the method is not limited by an installing position, malfunction caused by disturbance of operating arc generated by normal circuit opening and closing and loads such as a switch power and a dust collector can be avoided well, and the reliability is high.


In the fall of 2001, the editors of BioTechniques decided to launch a new quarterly Supplement Series to address the critical issues currently facing the biological research laboratory. It was more than fitting that they chose to devote the first edition to the emerging field of Computational Proteomics. The goal was to gather experts in the fields of bioinformatics and proteomics to explore the role of these technologies in drug discovery. The emphasis was to evaluate the bottleneck of the vast amount of protein data being generated and the different strategies that are being developed to overcome this bottleneck and accelerate the underlying process of identifying drug targets. It seems appropriate to introduce this publication with a brief historical background on the development of the science of proteomics followed by a short commentary on each article appearing in this issue. In 1945, Fred Sanger developed one of the first methods for protein characterization by amino acid sequence analysis using fluorodinitrobenzene as part of his first Nobel prize winning work on the structure of insulin. A more efficient approach that used sequential degradation of residues from the amino terminus with phenylisothiocyanate was described in 1950 by Pehr Edman. Although a large number of protein sequences have been determined using automated "Edman degradation" over the years, the method is quite time-consuming and not amenable to large-scale identification of proteins and their primary structures. In the meantime, the advances in nucleic acid sequencing techniques and the ease of deduction of protein sequences from DNA sequences was reflected in an article published in Nature in 1978 entitled "The decline and fall of protein chemistry?" (4). As a young graduate student sequencing proteins under the supervision of the Nobel prize winning protein chemist Rodney Porter at the University of Oxford, I was obviously quite disappointed to read that. I did not have enough courage to ask him about the utility of becoming a protein chemist but posed the question to his PhD supervisor Fred Sanger. He assured me that the way developments were then taking place in recombinant DNA technology, in our time we should see advances in protein chemistry that had not even been contemplated at that time. He commented that we probably would be dealing with novel technology capable of characterizing proteins present in very trace amounts. I vividly remembered his words when fifteen years later, in 1995, it took me less than five minutes to analyze the tryptic digest of a protein band from a gel using a mass spectrometer and identify the protein by correlative sequence database searching. In most instances, that would now take less than a minute with the added luxury of a completely automated high-throughput process. The feasibility of such methods was first presented in a poster at the 1989 Protein Society Symposium in Seattle by W.J. Henzel, J.T. Stults, and C. Watanabe of Genentech and another one presented two years later at the Baltimore symposium by J.R. Yates, P.R. Griffin, T. Hunkapillar, S. Speicher, and L.E. Hood of Caltech (3). Since these contributions were not included in any published proceedings, the knowledge of the new method only gained limited circulation. It was not until 1993 that similar studies from five different groups appeared in the scientific literature. The word proteome, indicating proteins expressed by a genome, was coined by Marc Wilkins and colleagues and first used in late 1994 at the Siena 2-D Electrophoresis meeting and appeared in published literature for the first time in July, 1995 (5). It is interesting to note that in the same month, the first complete sequence of the genome of a living organism, Haemophilus influenzae Rd, was published. In the interim period, the complete sequence of several genomes has been determined, and the finished human genome will be available in the near future. However, our understanding of thousands to hundreds of thousands of proteins encoded by these genomes is lagging far behind. Since most of the cellular processes occur at the protein level, a thorough comprehension of the proteome, i.e., the pattern of proteins produced by a specific cell under a particular set of conditions, would definitely accelerate drug, vaccine, and diagnostic target discovery. Our current understanding of the human genome has led to the notion that there are fewer genes than originally thought, and this has become a strong driving force behind proteomics. Plans to elucidate the human proteome have been discussed at a meeting organized by the recently created Human Proteome Organization or HUPO (www.hupo.org) (1). In fact, the effort to produce an index of all human proteins, the human protein index, dates back to 1981 (2). The field of proteomics has rapidly expanded and includes diverse technologies like 2-D gel and mass spectrometry-based methods for protein profiling, protein microarrays, yeast twohybrid projects, protein-protein interaction pathways and cell signaling networks, high-throughput protein structural studies using mass spectrometry, nuclear magnetic resonance and X-ray crystallography, and high-throughput computational methods for protein 3-D structure as well as function determination. Two-dimensional (2-D) gel electrophoresis and mass spectrometry based methods are currently the major experimental technologies for large-scale as well as high-throughput analysis of proteomes focused on protein identification and their qualitative and quantitative comparison. In the review article, Deb Chakravarti, Bulbul Chakravarti, and Ioannis Moutsatsos have addressed the state-of-the-art software and informatic tools for proteome profiling using these techniques. These authors have drawn attention to the lack of significant advances in the development of informatics and software tools to support the analysis and management of huge amounts of data generated in the process and integration of such information with other sources of protein structural and functional information. In this context the authors have discussed the importance of relational databases for protein profiling data management. Proteome profiling is a very powerful tool in clinical medicine for identification of diagnostic markers. Clinical applications of proteomics can also provide information on drug targets, the mechanism of drug action, and drug-mediated toxicity. Eric Fung and Cynthia Enderwick have provided an elegant background of the ProteinChip technology based on the surface enhanced laser desorption/ionization time-of-flight (SELDI-TOF) INTRODUCTION


Knowledge about the driving condition can be exploited by the energy management system of plug-in hybrid electric vehicle (PHEV) to optimise its fuel economy. However, estimating urban traffic speed can be a challenging problem, since the complexity of the road network requires a large amount of sensing coverage. GPS equipped vehicles have been used to address this problem, despite the drawback of high transmission cost due to the periodic locations reporting during the entire trip. This paper presents an alternative method to estimate urban traffic speed when only the trip distance, origin, destination and trip time are known, without the detailed information about the vehicle trajectory. Taxicab fleet data is used due to its wide area-coverage and large data availability. One month (15 million) observations of taxi origin-destination data in New York City is processed using cluster computers to create a traffic speed model of Manhattan at different times of day. The developed average traffic speed model is able to accurately predict the recorded trip duration from the taxicab data, and therefore, can be used to estimate energy consumption and optimise PHEV control.


The great popularity of smartwatches leads to a growing demand for smarter interactive systems. Hand gesture is suitable for interaction due to its unique features. However, the existing single-modal gesture interactive systems have different biases in diverse scenarios, which makes it intractable to be applied in real life. In this paper, we propose a multi-modal smartwatch interactive system named Mudra, which fuses vision and Inertial Measurement Unit (IMU) signals to recognize and identify hand gestures for convenient and robust interaction. We carefully design a parallel attention multi-task model for different modals, and fuse classification results at the decision level with an adaptive weight adjustment algorithm. We implement a prototype of Mudra and collect data from 25 volunteers to evaluate its effectiveness. Extensive experiments demonstrate that Mudra can achieve 95.4% and 92.3% F1-scores on recognition and identification tasks, respectively. Meanwhile, Mudra can maintain stability and robustness under different experimental settings.


This paper studies the Fujita phenomena for the Cauchy problem to semilinear parabolic equations coupled via the time-weighted sources . The critical curve is determined for a wider range of parameters, where with . In particular, the decay cases of and are also included.


We present an electro-optic modulator exploiting a metamaterial made of an array of vanadium dioxide nanorods operating in epsilon near zero regime as the active switching material in a silicon waveguide. The modulator takes advantage of the insulator-to-metal transition of vanadium dioxide together with epsilon near zero to achieve a robust modulation depth of 20.35 dB over a broad range of wavelengths. Using simulations, we demonstrate how the effective permittivity of metamaterial can be tuned to a near-zero value by varying the nanorod geometry. The results provide insight into the design of ultra-compact epsilon-near-zero modulators with high operation frequencies and low insertion losses.


A method and an instrument structure for calibration of infrared target simulator is analyzed.A strict and proper mathematical model for calibration of the infrared target simulator is derived.


This paper presents a feeder reconfiguration problem in distribution systems. The objective is to minimize the system power loss and to improve bus voltage profile. The optimization problem is subjected to system constraints consisting of load-point voltage limits, radial configuration format, no load-point interruption and feeder capability limits. A method based on genetic algorithm, a search algorithm based on the mechanics of natural selection and natural genetics, is proposed to determine the optimal pattern of configuration. The developed methodology is demonstrated by a 33-bus radial distribution system with distributed generations and feeder capacitors. The study results show that the optimal on/off patterns of the switches can be identified to give the minimum power loss while respecting all the constraints.


The check list of freshwater ostracods of Indiana raises the number of ostracods re- ported from Indiana from 6 to 24. The list is a result of a survey taken in the spring of 1968 in Delaware County. The list includes the descriptions of 2 new species: Potamocypris brachychaeta and Candona ginnensis.


The prevalence of obesity and an increased incidence of thyroid carcinoma (TC) threaten public health in parallel on a global scale. Sufficient evidence supports excess body fatness in thyroid carcinogenesis, and the role and anthropometric markers of obesity have been causally associated with the rising risk of TC.


The tropical peatlands in Central Kalimantan have been extensively and intensively degraded as a result of unsustainable land management impacting the vast fire hazard of the last 3 decades. One of them is in Ex-Mega Rice Project (EMRP) one million hectare in Block A, Sei Ahas Village, Mentangai, Kapuas District, Central Kalimantan opened in 1995-1996 which was discontinued in 1999. Peatlands clearance has become a crucial issue related to peatland wildfires. The largest fires has occurred in 2015. Damage caused to peatlands degradation in Kalimantan and Sumatra, mainly due to: agricultural activities, irrigation/drainage networks, illegal logging, and wildfires. This present research will identify the correlation of peat degradation and peatland wildfires trigger with restoration process. Restoration process that has been built in that area is canal blocking (tabat). Method that used in this research are observations and laboratorium process. Peat sample tested by peat ability in absorb water in some treatments. Based on observations of peatlands degradation represented by canal C (without tabat) with canal restoration process on canal E (tabat 1) and D (tabat 2) after wildfires hazard in 2015 with direct observation and peat water absorb capacity testing. It is found that canal E that had a longer through restoration process provides better results in absorbing water. Ecosystems in upstream canal E also show better results from the restoration process.


Introduction: There is a large disparity between the ''cultural'' language used by patients using cannabis for selfmedication and the ''chemical'' language applied by scientists to get a deeper understanding of cannabis effects in laboratory and clinical studies. The distinction between Sativa and Indica types of cannabis, and the different biological effects associated with them, is a major example of this. Despite the widespread use of cannabis by selfmedicating patients, scientific studies are yet to identify the biochemical markers that can sufficiently explain differences between cannabis varieties. Methods: A metabolomics approach, combining detailed chemical composition data with cultural information available for a wide range of cannabis samples, can help to bridge the existing gap between scientists and patients. Such an approach could be helpful for decision-making, for example, when identifying which varieties of cannabis should be made legally available under national medicinal cannabis programs. In our study, we analyzed 460 cannabis accessions obtained from multiple sources in The Netherlands, including hempand drug-type cannabis. Results: Based on gas chromatography analysis of 44 major terpenes and cannabinoids present in these samples, followed by Multivariate Data Analysis of the resulting chromatographic data, we were able to identify the cannabis constituents that may act as markers for distinction between Indica and Sativa. This information was subsequently used to map the current chemical diversity of cannabis products available within the Dutch medicinal cannabis program, and to introduce a new variety missing from the existing product range. Conclusion: This study represents the analysis of the widest range of cannabis constituents published to date. Our results indicate the usefulness of a metabolomics approach for chemotaxonomic mapping of cannabis varieties for medical use.


One thousand years ago, a handful of dynamic medieval city states developed trade at the frontier of capitalism. Their unique commercial ambition led to the emergence of finance capitals of international significance: Finance Masters. From the 11th century onward, international financial hubs, led by astute and bold merchant bankers and visionary leaders, inspired the numerous innovations that triggered economic revolutions in the last millennium and laid the ground for modern finance. This book explores not only classic financial centers, but also offshore financial centers and gambling centers to connect them to contemporary finance, and it also delves into the unique function of leading financial hubs to execute financial transactions over a wide geographical domain and transform the world economy.


A long line of research has shown that despite their lower socioeconomic standing, Hispanics have lower mortality rates relative to Whites. In a separate literature, scholars have shown that Hispanics are increasingly relocating and shifting their destination choices within the US. Using 1999–2010 county-level national vital statistics data, this paper combines these two research domains by comparing Hispanic and White all-cause mortality rates and their differentials in new and established Hispanic destinations. The results reveal that the Hispanic mortality advantage in established destinations is much smaller relative to the rest of the nation owing to significantly higher Hispanic mortality rates. Utilising spatial regression techniques, the study also compares the ecological correlates of White and Hispanic mortality rates and their gaps across Hispanic destinations. The results show that the structural factors associated with mortality gaps vary by destination type except for the percent of Hispanics that are recent immigrants, which is associated with a greater Hispanic mortality advantage in all areas. In addition to providing support for a healthy migrant effect, the results also reveal the importance of internal Hispanic migration, which is associated with larger gaps in established areas. Lastly, factors associated with White mortality, particularly local socioeconomic conditions, are associated with larger mortality gaps, specifically in new destinations. The study highlights the increasing need to consider geographic heterogeneity in White and Hispanic health and mortality outcomes given the expanding dispersion of Hispanics into areas that until recently attracted few Latinos. Copyright © 2015 John Wiley & Sons, Ltd.


The purpose of this research is to improve the condition of the online class, especially the activeness of students during the synchronous and asynchronous learning process. This study is also to determine the increase in student learning outcomes on vektor material. Learning uses the Group to Group Exchange (GGE) model in online classes and blended learning assisted by WhatsApp. This study uses a classroom action research design which consists of two cycles. The research subjects were students of Class X MIPA 1 SMAN 1 Jetis Ponorogo. Data on student activity includes discussion activities (asking or answering questions), presentations, and giving responses. This data was collected through observation sheets. Data about student learning outcomes are obtained through written tests or quizzes after the cycle takes place. Data were analyzed using descriptive statistical methods. The results of the analysis showed an increase in activity and learning outcomes after learning using the GGE steps. GGE consists of (1) material distribution; (2) group distribution; (3) group discussion in the WA group; (4) presentation and group responses in the class WA group; and (5) evaluation. Class action taken in the form of reshuffling group members and face-to-face meetings. Student activity increased, in cycle I when online using WhatsApp, all student activities were recorded on WhatsApp chat only 54%. Group discussions in the WA group were less than optimal and presentations using photo sharing and voice notes were also less than optimal. While in the second cycle when blended learning, group discussions using WhatsApp group and face-to-face while face-to-face presentations, student activity became 88%. The learning outcomes of students whose scores are greater than the KKM increased from 24% in the first cycle to 72% in the second cycle, with the class average increasing from 48.48 to 81.76. The results of this study indicate that using a GGE based on WhatsApp-assisted blended learning can significantly increase student activity and learning outcomes.


Objective: The objective of present study was to evaluate the antibacterial and antioxidant activities of essential oils from Thymus vulgaris, Thymus kotschyanus, Ziziphora tenuior and Ziziphora clinopodioides. Methods: The antioxidant potency of essential oils was determined by 2,2-diphenyl-1- picrylhydrazyl and reducing power assays. Total phenolic contents of essential oils were determined using the Folin-Ciocalteu reagent assay. The antibacterial activity of essential oils was evaluated using agar disc diffusion and minimum inhibitory concentration (MIC) methods. Results: The essential oils of Ziziphora clinopodioides and Thymus vulgaris showed the highest antioxidant activity. The essential oils of Thymus vulgaris showed the strongest antibacterial activity with the widest inhibition zone and the lowest MIC value (2.5 μl/ml). The essential oils of Thymus vulgaris had the highest concentration of total phenolics (116.5


Purpose: Research on teacher educators is fragmented but different trends are emerging from a variety of contexts that recognize it as a distinct profession. This research aims to highlight the features of a potential UAE teacher educator framework that has emerged from my research on authentic professional learning, and where professional learning might be focused in the future to build on teacher educators' professional knowledge in the UAE. This paper explores the potential characteristics of a UAE Teacher Educator Framework through the methodological lens of narrative inquiry.
Approach/Methodology/Design: Teacher educators have formal associations in the USA, Belgium, The Netherlands, Israel, and Australia and these associations have professionalized the industry and created standards and frameworks to support professional learning. No such associations or standards exist in the United Arab Emirates. Drawing on the work of Keltchermans (2018), Kreijns (2019) and the existing frameworks from other contexts, this paper illustrates the potential blueprint for the UAE education sector.
Findings: The findings suggest that inter-cultural learning and sensory awareness of the contextual factors that underpin the sector may allow teacher educators to feel empowered to support teachers and their peers in a complex cultural and economic environment.
Practical Implications: The practical implications propose a new way of working and thinking within the UAE context, and the framework can be applied and adapted to both the public and private sectors.
Originality/value: Teacher educators have formal associations in the USA, Belgium, The Netherlands, Israel, and Australia and these associations have professionalized the industry and created standards and frameworks to support professional learning. No such associations or standards exist in the United Arab Emirates so this work offers significant value in an under-researched space.


Currently, it is very hard for companies driven by personal data to make their applications GDPR-compliant, especially if those applications were developed before the GDPR was established. We present rgpdOS, a GDPR-aware operating system that aims to bring GDPR-compliance to every application, while requiring minimal changes to application code.


Both hypochondriasis patients and suspected patients are results of the doctors' diagnosis,although there are some incommon,the basic psychology characters between them are different.For patients,the diagnoses will cause anxiety,insecurity.Hypochondriasis patients' psychological disorders are intrinsic and relating to their psychological tendency and personality,while suspected patients' are exogenously and relating with their physical symptoms.Under certain conditions,the role of the two patients can be inter-transformed.For hypochondriasis patients,long term bad mood results in the suspected disease;while suspected patients with high neurotic personality may become hypochondriasis patients.So during the course of psychotherapy,we should pay attention to the different characteristics of the two patients,so different measures should be taken.


This paper investigates the limiting wave conditions at which a wind turbine technician can complete maintenance activities safely and effectively on a 15MW floating offshore wind turbine. Through linear, frequency-domain statistical analysis of floating turbine motion and applying acceptable motion limits for technician working, significant wave height and peak wave period limits are investigated. It was found that over the range of wave conditions considered, the turbine nacelle motion did not exceed the motion limits for technician working considered in this analysis. Further analysis found that the turbine nacelle motion increased with increasing significant wave height and was also significantly influenced by peak wave period. The impact of differing wave characteristics is also investigated through the use of different wave energy spectra and also found to have an impact on turbine nacelle motion.


Abstract : Lithium, Potassium, and Cesium ion sources have been studied using devices based on thermal emission from a Beta Eucryptite structure as possible ion sources for use in satellite charge control. The experiments evaluated the power requirements of the different ion emitters to produce approximately 10 (microamps) of current and tested the effects of using an Osmium Ruthenium coating to increase the work function of the emitter surface. Lifetime tests of the different ion emitters were also performed. Analysis of the experimental findings showed that lithium ion sources with a lifetime of 93 hours and Potassium ion sources with a lifetime of 44 hours produced acceptable current levels for use in spacecraft charge control devices. Potassium sources produced the necessary current, (10 microamps), at 140 (C) lower temperature than the Lithium sources. All of the coated sources produced wildly fluctuating currents at the 10 (microamp) level and were not acceptable for the purpose intended.


The role data from the first three LANDSAT satellites have in geologic exploration and their current level of acceptance is reviewed and the advantages of LANDSAT 4 TM data over MSS data are discussed. Specially enhanced Thematic Mapper imager can make a very significant contribution to the oil and gas and mineral exploration industries. The TM's increased spatial resolution enables the production of larger scale imagery, which greatly increases the amount of geomorphic and structural information interpretable. TM's greater spectral resolution, combined with the smaller, more homogeneous pixels, should enable a far greater confidence in mapping lithologies and detecting geobotanical anomalies from space. The results from its applications to hydrocarbon and mineral exploration promise to bring the majority of the geologic exploration community into that final stage of acceptance and routine application of the satellite data.


Justin Clemens Dominiek Hoens At first sight, politics and melancholia can only appear as an odd couple. Whereas the realm of politics evokes enthusiastic activity and strategic interests, melancholia is generally associated with passive contemplation and a lack of worldly engagement. If politics connotes vital, future-oriented struggles over the divisions of the community, melancholia suggests individual incapacitation, even dissolution, by predatory hangovers from the past. Hence, if one were to identify a relation between both terms it would seem to be an inversely proportional one: an increase of politics would be concomitant with a decline of melancholia, and vice versa. Such an opposition is at once supported and complicated by the astonishingly extensive modern scholarship regarding the history of melancholia, which ranges across the fields of philosophy, literature, art and medicine. As Giorgio Agamben points out in an important study of the condition, the ancient analyses of the operations and implications of black bile – which find a locus classicus in the Aristotelian Problemata, whose author invokes hoi melancholikoi – come to be associated by the Middle Ages not only with philosophy, poetry and arts, but with a moral malady as well.1 We subsequently discover periodic plagues of melancholia troubling the history of Western life, attested to by all sorts of evidence, not least that provided by the most outstanding creative types, Albrecht Dürer and William Shakespeare among them. As J. L. Koerner proposes of Dürer's own famous image of Melencolia I, in the wake of such eminent commentators as Saxl and Panofsky, Warburg, and Walter Benjamin:


Epilepsy South Africa, is the national epilepsy organization, which has branches in various provinces in the country (www.epilepsy.org.za). It was formally known as the South African National Epilepsy League (SANEL). In April 2002, the name and logo of the organization changed to Epilepsy South Africa (Fig. 1). The mission of the organization is to provide equitable services to people with epilepsy and other disabilities, which include psychotherapeutic intervention, public education, and economic empowerment programs, as well as research and advocacy. These services are provided at health facilities, educational institutions, corporate companies, social institutions, and welfare organizations. Figure 2 illustrates the message of hope that the organization aims to relay.


SUMMARY. 1. In a cuirophic pond in southern England. the snail Lymnaca peregra(Mull.) is associated with submersed macrophyies, mainly Elodea canadensis Michx. In contrast, the snail Planorbis vortex(Linn.) is associated with the emergent macrophyte Glyceria maxima(Hartm.) Holmberg.

2. L. peregra grazed selectively on filamentous green algae found only on E. camtdensis. P. vortex selected diatoms. Detritus, which was 5 times more abundant on G. maxima than on E. canadensis. comprised about 60% of the diet of P. vortex.

3. Results of experiments giving both snail species a choice between periphyton-detritus removed from the two macrophytes were consistent with the field observations. L. peregra c hose pcriphyton-detritus from E. canadensis whereas P. vortex chose that from G. maxima.

4. Although other factors may have influenced the distributions of L. peregru and P mriex in Radley Pond, food choice was probably the most important proximate factor.


From the Publisher:
Provides readers with a clear understanding of the structure of library automation systems along with enough information about underlying algorithms, file structures, and processing strategies to enable them to evaluate vendor products, build a system using the techniques described and continue to improve their own library system. After explaining the basics of traditional automated library systems, the author presents an integrated library system as well as the tools which aid in the design of all aspects of these systems. The tools are available for use and modification via anonymous FTP over the Internet and readers can build systems or just experiment with these tools.


Telepharmacy involves pharmacist provision of clinical services at a distance and often includes electronic health record integration, audio-video connections, and increased patient access to pharmaceutical care. With the rapid expansion of this field comes critical questions that need to be answered by forward-thinking people in the profession. These issues include centralized checking workflows, potential reductions in patient counseling, and increased technician independence and responsibilities. If these points can be addressed with the needs of patients at the forefront, telepharmacy is poised to significantly advance access to care.


This article deals with workfare reforms in the 1990s and the way they impact the current debate on public workers in the United States. It focuses on New York and shows the consequences of a combination of factors: the specific institutional development of trade-unions in NY, the way local associations gave up on welfare and finally the streamlining of public services all jointly led to a deteriorating of working conditions in the public sector. These factors also paved the way for a weakening of the rights and status of public agents as illustrated also in Wisconsin.


The potential recyclability of healable asphalt mixtures has been analyzed in this paper. A healable porous asphalt mixture with steel wool fibers was artificially aged in order to assess its recyclability. This mixture was used as reclaimed asphalt in a new porous asphalt mixture, whose mechanical and healing capacities were studied and compared with the behavior of the original porous asphalt mixture. The quantity of reclaimed asphalt mixture added was 40%; besides, in order to recover the properties of the aged binder, and incorporate the last advances in the recyclability of bituminous mixtures, a rejuvenator was also added (SYLVAROAD™ RP1000). The voids test, Cantabro particle loss test, water sensitivity test, stiffness test, and fatigue resistance test were performed to mechanically study the experimental mixture, while the last one (fatigue resistance test) was also used to assess its healing capacity. The results have shown that the healing capacity of the original healable porous asphalt mixture is maintained with similar mechanical performance.


The graduation students have many advantage in taking part in nurse qualification test.Bu there exist some problems.School must attach importance to the graduation students' taking part in nurse qualification test,guide them to prepare for it and adopt the relevant measures to improve their pass rate.


Abstract : Several proteins associated with oocyte development in Plodia interpunctella were isolated and characterized. Conditions were established for the long term culture of fat body and ovaries, which produce these proteins. The concentration of ecdysteroids, the major hormones associated with metamorphosis and the initiation of ovarian development, was measured by radioimmune assay and HPLC. Ecdysteroids reach a major peak at the beginning of adult development when the oocytes begin to mature. The concentration then declines gradually as development continues to eclosion. The decline may be a means for controlling sequential development of adult structures because elevating hormone titre by injection delays development. Protein synthesis in ovaries is substantially reduced and oocytes do not sequester yolk precursors from the hemolymph. The fat body synthesis protein at what appears to be a normal rate but elevated titres slow the utilization of what has been identified tentatively as storage protein. Fat body and ovaries can be maintained in culture for periods equal to the time of metamorphosis.


An IC/MS method was developed using thermospray and electrospray interfaces to obtain the mass spectra of ionic compounds in agricultural chemicals. This is an easy, rugged, and sensitive method and offers several advantages over the conventional HPLC/MS with ion-pairing reagents for the analysis of highly polar compounds. Ion exchange chromatography was used to separate the ionic compounds from other components in the sample. Sodium hydroxide mixed with methanol and water was used as the eluent. To make the eluent containing sodium hydroxide compatible with MS, an on-line solid-phase chemical suppressor was used, which removed sodium ions from the mobile solvent before it entered the mass spectrometer. The suppressor is easy to use, is rugged, and can withstand the high back-pressure generated by the thermospray LC/MS interface. It also works well with the electrospray interface.


Lara is 25 years old and she manifests stuttering. Her case is presumably presented to a neurologist, psychologist and linguist. The neurologist represents the objectivism, the psychologist represents subjectivism and the experimental and clinical linguist represents constructionism. They are all seeking for knowledge with different beliefs for each one of them. The truth that each one is going to reach must have acceptable, efficient and effective justifications. Through this scenario, I intend to present the argument of the social and natural worlds—furthering the view that the two worlds exist together with different methods to uncover them!


Objective To analyze the epidemiological characteristics of the xinjiang Uygur patients in hypertension,as well as to explore the clinical effect after nursing intervention in patients with hypertension.Methods Adopt random sampling method,329of 18or xinjiang Uygur hypertension epidemiological investigation and blood biochemical test,as soon as randomly selected the acuity of xinjiang Uygur healthy adults 18,299 as a comparison.In order to improve the patients understanding of disease and treatment compliance through the hospital health education and clinical nursing,psychological nursing.Results On 5×2×2 factorial analysis,there was differences(P 0.05)with statistical significance in systolic pressure,diastolic pressure level,and two groups of different ages have statistical significance(P0.05),and TG as well as TC between hypertension group and normal blood pressure group,while high blood pressure group was obviously higher than that of normal blood pressure group.So blood pressure levels for hypertension under control through behavior life style,diet adjustment,such as the proper use of antihypertensive drugs.Conclusion Health education and clinical care include reducing salt intake,increasing medication compliance,etc,plays an important role in hypertension patients blood pressure control.


Welcome to the August edition of The Queensland Surveyor for 2000. This edition contains a variety of topical issues, with an interesting comment of the future short-term applications of using Global Positioning Systems in a non-selective availability environment. For Surveyors, there is an increasing scope and potential markets to provide foundation spatially related information using a diversity of data-collection, analysis and presentation technologies.


Introduce a new emplicit iterative process for a finite family of asymptotically quasi-nonexpansive mappings in Banach spaces,and then we prove some convergence theorems for this class of emplicit iteration process.The results presented in this paper improve and extend some recent results.


Abstract Objectives: Compare costs and healthcare resource utilization (HCRU) among newly-diagnosed non-valvular atrial fibrillation (NVAF) patients newly treated with dabigatran vs apixaban, rivaroxaban, or warfarin. Methods: Newly-diagnosed adult NVAF patients initiating dabigatran, apixaban, rivaroxaban, or warfarin (index event) between October 1, 2010–December 31, 2014 were identified using MarketScan claims data, and followed until medication discontinuation, switch, inpatient death, enrollment end, or study end (December 31, 2015). Dabigatran patients were propensity-score matched 1:1 separately with apixaban, rivaroxaban, and warfarin patients. Per-patient-per-month (PPPM) all-cause cost, HCRU, and 30-day re-admissions were reported. Costs were analyzed using generalized linear models. Results: Final cohorts, each matched with dabigatran patients, included 8,857 apixaban patients, 26,592 rivaroxaban patients, and 33,046 warfarin patients. Dabigatran patients had lower adjusted PPPM total healthcare, inpatient, and outpatient costs compared to rivaroxaban ($4,093 vs $4,636, $1,476 vs $1,862, and $2,016 vs $2,121, respectively, all p ≤ .001) and warfarin ($4,199 vs $4,872, $1,505 vs $1,851, and $2,049 vs $2,514, respectively, all p < .001). Adjusted costs were similar for dabigatran and apixaban. Dabigatran patients had significantly fewer hospitalizations, outpatient visits, and pharmacy claims than rivaroxaban patients (0.06 vs 0.07, 4.84 vs 4.96 and 4.80 vs 4.93, respectively, all p < .020) and warfarin patients (0.06 vs 0.07, 4.77 vs 6.88, and 4.76 vs 5.89, respectively, all p < .001). Dabigatran patients had similar hospitalizations to apixaban, but higher outpatient visits (4.70 vs 4.31) and pharmacy claims (4.86 vs 4.61), both p < .001. Conclusions: This real-world study found adjusted all-cause costs were lower for dabigatran compared to rivaroxaban and warfarin patients and similar to apixaban patients.


Certain commercial entities, equipment, or materials may be identified in this document in order to describe an experimental procedure or concept adequately. Such identification is not intended to imply recommendation or endorsement by the National Institute of Standards and Technology, nor is it intended to imply that the entities, materials, or equipment are necessarily the best available for the purpose. This document provides instructions for latent print examiners in marking friction ridge features to maximize consistency among examiners. Information Technology Laboratory (ANSI/NIST-ITL) 1-2011. These instructions include examples and specific guidance for latent print examiners and minimize references to technical details of the file format. Three interrelated specifications have been designed to enable vendor-neutral latent automated friction ridge identification systems (AFIS) interoperability: the EFS Profile Specification; the Latent Interoperability Transmission Specification; and this one, the Markup Instructions for Extended Friction Ridge Features. The three documents define data exchange specifications for latent print interoperability and are all based on the EFS features in the ANSI/NIST-ITL (2011) standard.


Background: Tenascin-C (TNC) is a pro-inflammatory extracellular matrix glycoprotein that is synthesized in various pathological conditions. TNC induces inflammatory activity and promotes damage of joints. Its expression in adults is restricted to sites of tissue injury, particularly during phases of inflammation and active tissue remodelling. Only a few studies have described elevated serum TNC levels in ankylosing spondylitis (AS) compared to healthy controls (HC). Objectives: The aim of this study was to examine the levels of serum TNC among different axial spondyloarthritis (axSpA) subsets and whether TNC levels are related to disease activity measures or other clinical features. Methods: Sixty-one patients who fulfilled the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axSpA and twenty age and sex-matched HC were included in this study. Based on imaging, patients were further classified as AS (n = 45) and as nr-axSpA (n = 16). Patients with AS were further divided into two subsets based on the absence (n=22) or presence of syndesmophytes (n=23). TNC serum levels were determined using ELISA. The following data were collected: clinical and laboratory disease activity measures; demographic status; disease-related factors such as the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and CRP levels. Statistical analyses were performed with GraphPad Prism 5.1. The data are presented as the median and interquartile range. Results: TNC serum levels were elevated in axSpA patients (535.3 (457.7-677.2) ng/mL) compared to HC (432.1 (329.1-565.9) ng/mL, p= 0.007). Dividing axSpA into nr-axSpA and AS subsets the difference was observed only between AS patients and HC (535.3 (434.5-677.2) vs. 432.1 (329.1-565.9) ng/mL, p=0.022). TNC serum levels did not correlate with disease activity biomarkers (serum CRP or BASDAI) in patients with axSpA. Although we have not observed correlation between TNC and mSASSS radiographic score, weak correlation with disease subsets was found (r=0.25, p=0.025). Conclusion: We demonstrated here elevated serum TNC levels in patients with axSpA, particularly in those with syndesmophytes, which may suggest its role in bone formation during radiographic stage of the disease. Acknowledgement: This work was supported by MH CR 023728, SVV 260373, AZV - 17-33127A Disclosure of Interests: Hana Hulejova: None declared, Kristyna Bubova: None declared, Klára Prajzlerová: None declared, Marketa Husakova: None declared, Mária Filková: None declared, Michal Tomčík: None declared, Karel Pavelka: None declared, Ladislav Šenolt Grant/research support from: AbbVie, Consultant for: AbbVie, Bristol-Myers Squibb, Celgene Corporation, Merck Sharp and Dohme, Novartis, Pfizer, Roche, UCB, Amgen, Takeda, Speakers bureau: AbbVie, Amgen, Bristol-Myers Squibb, Celgene Corporation, Eli Lilly, Merck Sharp and Dohme, Novartis, Pfizer, Roche, UCB


A performance-based approach is developed for adaptive robust control of linear systems with uncertain parameters. The dual control objective involves the disturbance attenuation and worst case identification of the unknown parameters. The proposed synthesis procedure relies on sufficient conditions, given in terms of suitable solutions of perturbed differential Riccati equations to exist. Although being reminiscent from the standard $\mathcal{H}_{\infty}$ synthesis, the resulting Riccati equations are to be updated on-line with estimated values of the unknown plant parameters. Capabilities of the proposed synthesis are illustrated by simulations made for a scalar linear system with unknown parameters.


This literature focuses on grid resource monitoring and prediction, representative monitoring and prediction systems are analyzed and evaluated, then monitoring and prediction strategies for grid resources are summarized and discussed, recommendations are also given for building monitoring sensors and prediction models. During problem definition, one-step-ahead prediction is extended to multi-step-ahead prediction, which is then modeled with computational intelligence algorithms such as neural network and support vector regression. Numerical simulations are performed on benchmark data sets, while comparative results on accuracy and efficiency indicate that support vector regression models achieve superior performance. Our efforts can be utilized as direction for building online monitoring and prediction system for grid resources.


Reasons for coming to UW; Experimental College; UW presidents; Treatment of students; George Sellery deanship; T. S. Eliot visit to Madison; Madison in 1920s; Depression; Faculty antipathy to emphasis on intellectual achievement; Failure to address student writing problems; Ruth Wallerstein; Publish or perish in humanities; Campus architecture; McCarthy hearings; Rotating chairmanship.


Fetal ECG and Doppler ultrasound signals provide clinically significant information concerning the physiological state of a fetus. In this study, we propose a non-invasive system to recognize the timings of fetal cardiac events on the basis of analysis of fetal ECG and Doppler ultrasound signal together. Fetal ECG was extracted from transabdominal ECG (10 normal subjects, 38-41 weeks of gestation) using blind source separation with the reference signal. Multiresolution wavelet analysis enabled the frequency contents of the Doppler signals to be linked to the opening and closing of the heartpsilas valves (Aortic and mitral). The time intervals from R peak of fetal ECG to opening and closing of aortic valve were found to be 99.16plusmn22.07 (msec) and 222.70plusmn21.83 (msec) respectively. The time intervals from R peak to opening and closing of mitral valve were found to be 305.32plusmn22.71 (msec) and 37.84plusmn18.23 (msec) respectively.


The plant Pergularia daemia (Asclepiadaceae) is traditionally used as a medicinal agent and they are widely distributed to tropical and subtropical region of India. Therefore, the present work has been designed to evaluate antioxidant and cytotoxicity potential of Pergularia daemia so as to claim folklore uses of P. daemia. The in vitro antioxidant activity was studied using DPPH Scavenging, Nitric Oxide Scavenging and β-carotene-linoleate scavenging model and cytotoxic activity of AEPD was studied by the MTT assay using using A-549 (Human, Lung Carcinoma) HT29 (Colon Carcinoma) cell lines. AEPD was studied at different concentrations, in which it showed a moderate to potent activity which confirms that it is having cytotoxic activity. AEPD was also studied for its in vitro antioxidant property by different methods. AEPD has a hydrogen donating property, which may be attribute to the good antioxidant activity. The in vitro data suggest that the extract is having both the in vitro antioxidant and cytotoxicity activity.


This paper studies on data dissemination for mobile sink groups in wireless sensor networks. A mobile sink group denotes a set of tightly coupled mobile sinks for team collaborations such as a team of firefighters and a group of soldiers. This mobile sink group has a collective movement feature. That is, even though sinks in a group randomly move in their own personal spaces, they collectively move together as a single entity. For mobile sink groups, previous studies provide flooding-based protocols that determine immediate areas of a group at moments, which are successive snapshots of a group continuously moving, and then propagate data within the areas by flooding. However, since a group is still moving during decision of each snapshot, they cause asynchrony between an immediate area and the actual area at a moment. Eventually, it harms reachability and energy-efficiency. This paper therefore proposes a novel data dissemination protocol that takes into account continuous motion properties of a mobile sink group: slowly varying and streamlike movement. Based on the slowly varying property, the protocol predictively and effectively deliver data to a mobile sink group through a band of sensor nodes located in front of the streamlike trajectory of the group. Numerical analysis and computational simulations prove that this band-based data dissemination show better performances than the previous schemes with respect to both reachability and communication costs including data forwarding as well as signaling in a variety of scenarios.


OBJECTIVE To analyze the susceptible factors and resistance of Acinetobacter baumannii in ICU,in order to create a novel thought of effective prevention and control of A. baumannii cross-infection. METHODS Specimens were collected from ICU patients with infections from Sep 2006 to Sep 2008. The infection characteristic was analyzed and the drug sensitivity was tested to know the risk factors of infection retrospectively. RESULTS The factors of low immunity,severe wound,invasive operation and using ventilator led to the serious cross-infection of A. baumannii in ICU .In vitro drug susceptibility test,the sensitive rates only to cefoperazone/sulbactam and amikacin were higher. They were 65.09% and 72.64%,respectively. CONCLUSIONS It has great significance in the prevention and control of A. baumannii cross-infection in ICU to strengthen the environment disinfection,were education of nosocomial infection knowledge among medical staff,executeing the hand-washing system strictly,useing the antibiotics rationally,keeping the susceptible crowd and adopting de-escalation strategy of prevention and control.


To assist government authorities identify evacuation strategy shortly after the outbreak of disasters, this paper proposes a GIS based urban emergency decision support model for large-scale crowd evacuation. The architecture and function of the model is devised to meet the need of scientific decisions in emergency management, and an expert system integrated with GIS is designed for evacuation planning. By the technology of modularization with multi-layer architecture, an accurate real-time evacuation booting system is established. Experiment results show the feasibility of the proposed model to provide a novel development mode for the establishment of digital urban emergency management system.


Dental trauma is a serious health problem affecting the teeth and the general health as well. Sometimes, the traumatized tooth may end up with vitality loss. The possible consequences of pulp necrosis could be osteolytic lesions and radicular cysts. This case study reported a successful conservative non-surgical endodontic management of a massive trauma-related periapical lesion in a child 13-year-old.


The regional population forecasting model developed at the Bundesforschungsanstalt fur Landeskunde und Raumordnung (BfLR) in Bonn Germany is described. The formal structure and underlying assumptions of the model are outlined regional population forecasts for West Germany up to the year 2000 are presented and the model is then critically evaluated. An appendix contains an analysis of interregional migration in Bavaria for the years 1972 1977 and 1982. (ANNOTATION)


THE INVENTION RELATES TO A METHOD OF MANUFACTURING FERRULE OF NUCLEAR REACTOR VESSEL EQUIPPED INTERNALLY BLOCK KEY GUIDANCE FOR GUIDANCE OF INTERNAL EQUIPMENT. THE PROCESS ACCORDING TO THE INVENTION IS TO A COATING INTERNALLY VIROLE PARALLEL EXTERNAL STEEL LOW ALLOY BY THIN vENEER STAINLESS STEEL AND FIXED INSIDE THE COLLAR OF SUPPORT BLOCKS AND IT IS ESSENTIALLY WHEREIN IT IS TO ALLOW A NU A SURFACE STEEL LOW ALLOY OF THE COLLAR SURROUNDED BY VENEER STAINLESS STEEL AND DROP ON THIS SURFACE TROUGH A PLATING BY A PROCESS FOR ARC WELDING, ALLOY NICKEL TYPE INCONEL TO OBTAIN PROFILE HIGHLIGHT COMPARED TO vENEER STAINLESS STEEL MACHINING THEN THIS PLACAGE THEN THIS WELDING PLACAGE A ROOM REPORTED ALLOY NICKEL OF INCONEL TYPE, THROUGH A PROCESS OF ARC WELDING SUPPLY WITH ALLOY THE NICKEL TYPE INCONEL REMOVAL IN A GROOVE FORMED BETWEEN VENEER AND REPORTED PART.


profits in turn reduces the return to innovation, and a link between inflation and the growth rate emerges. We explore this relationship, relate it to the empirical literature on the growth-inflation connection, and quantify its welfare implications. In particular, we show that the costs of positive trend inflation are substantial. Furthermore, we consider two extensions to environments where these costs are especially pronounced, namely (i) the case where nominal rigidities exist in the labour market and (ii) the case of endogenous growth a la Benhabib, Perli and Xie (1994), where new varieties can complement pre-existing ones. We believe that our focus on nominal price rigidity is novel, as the existing theoretical literature on the link between trend inflation and growth mostly focuses on the trade-off between money holdings and other forms of saving.


The Hawthorne relay-assembly research has been misinterpreted as showing that interest in employees' well-being is sufficient to stimulate increased performance. In the original studies of this phenomenon, the assemblers of relays received considerable attention, but they also wanted to improve their performance and they were given feedback on how they performed. As a result, they learned to produce more relays. The "Hawthorne misunderstanding" is common in criminology, criminal justice, and other fields because authors have failed to recognize this explanation of improved work output. Producing real Hawthorne effects—that is, improvements in the performance of people—is important in action research, and such improvements are often the aims of scientists who pursue this form of research. To produce Hawthorne effects, foster the acceptance of performance goals or standards, provide feedback on performance, and remove obstacles to improved performance.


ABSTRACT The goal of professional learning is to be able to use and apply the newly acquired knowledge and skills to the workplace. Although learning transfer has been studied in management, human resource development, training, adult learning, and psychology, to date there are a limited number of empirical field studies. There are also few learning transfer models that consider local cultures as a factor impacting the transfer process. Recent learning transfer models have outlined the importance of organizational culture, but none have outlined the central influence of local cultures on learning. Given that adult learning is a social endeavour that is influenced by cultural factors, local cultures affect how adults learn and whether they apply the new knowledge to their workplaces. In this paper, I share a Multidimensional Model of Learning Transfer that is grounded in culture. In today's global economy, people regularly work across nations and local cultures. As a result, it is essential that human resources administrators understand the role local culture plays on the entire learning transfer process, from pretraining to follow-up, if they aspire to obtain a return on their financial, time, and human investments.


In accordance with the development trend of the long distance control of visual multimedia control system, an implementation approach of Visual Multimedia Control System framework Based on MCF5249+μClinux were proposed, and the framework on key technology and secure design tested analysis were discussed. This system is based on MCF5249 Freescale 32-bit MCU, for achieving clipping transplanting of embedded μClinux OS and seamless integration of numeric embedded video.


Two structures super-resolution near-field phase-change optical disks with masks Sb2 Te3 layer and a thermal shield layer in front of the mask layer on Blu-ray substrates were studied theoretically and experimentally. Optical simulation was conducted and the modulation transfer function (MTF) was calculated. MTF calculation results has revealed that the super-RENS optical disk exhibited the maximum response when nearly half of the laser spot was covered by the mask. The thermal simulation was used to find the optimum condition meaning that half of the laser beam is covered by the aperture on the mask layer. The recording signal and thermal stability on different structures were measured and analyzed. The simulation results are in good agreement with the experiment results.


This paper deals with the cultural background of the concept of love in Hümâyûn-nâme (an Ottoman translation of Kalilag and Damnag) and contextualization dimensions of perception of love in fables. Therefore, it is necessary to deal with how the concept of love was perceived in the cultural setting in which the fables in Hümâyûn-nâme were produced. In this context, how the concept of love was perceived in the Oriental culture was described in general lines. Moreover, a general overview of the work was presented so that the readers could gain a better understanding of Hümâyûn-nâme. This paper aims at classifying the contextualization of the perception of love in the fables of Hümâyûn-nâme which forms the main backbone of this paper and it aims at exploring at what stages the perception of love occurred. Furthermore, it also deals with in what kind of perception of meaning the concepts of love were assessed in the work of art. Since the perception of love in Hümâyûn-nâme centers around humanitarian love, the abstracts of six fables which deal directly with humanitarian love were added in the appendix so that the readers would have a better understanding of the topic.


Simple Summary Clinical management of neuroendocrine neoplasms (NEN), especially of those low in target molecules such as somatostatin receptors, may benefit from the discovery of novel targets. This study identified and confirmed angiotensin II (ATII) as a strong activator of signaling in NEN cells and its cognate receptor AGTR1 as overexpressed in human small intestinal NEN. NEN cells with high AGTR1 expression exhibited cellular activation and secretion upon stimulation with ATII. AGTR1 ligand saralasin coupled to a fluorescent dye demonstrated tumor accumulation in an animal model of NEN. This proof of concept establishes AGTR1 as a novel target in NEN, paving the way for its potential use in diagnostic PET imaging and radioligand therapy. Abstract This study identified and confirmed angiotensin II (ATII) as a strong activator of signaling in neuroendocrine neoplasm (NEN) cells. Expression analyses of the ATII receptor type 1 (AGTR1) revealed an upregulation of mRNA levels (RT-qPCR) and radioligand binding (autoradiography) in small-intestinal (n = 71) NEN tissues compared to controls (n = 25). NEN cells with high AGTR1 expression exhibited concentration-dependent calcium mobilization and chromogranin A secretion upon stimulation with ATII, blocked by AGTR1 antagonism and Gαq inhibition. ATII also stimulated serotonin secretion from BON cells. AGTR1 ligand saralasin was coupled to a near-infrared fluorescent (NIRF) dye and tested for its biodistribution in a nude mouse model bearing AGTR1-positive BON and negative QGP-1 xenograft tumors. NIRF imaging showed significantly higher uptake in BON tumors. This proof of concept establishes AGTR1 as a novel target in NEN, paving the way for translational chelator-based probes for diagnostic PET imaging and radioligand therapy.


This paper makes an introduction and a summary of three tourism system models offered by scholars both at home and abroad:functional tourism model; chaotic tourism model and geographical tourism model. The paper points out that the study on geograpical tourism model with non-lineal feature will become an important study orientation of future tourism science.


We propose a software architecture, which addresses the interoperability problem in multiple database systems. The architecture avoids integration, centralisation of data and structures, and use of common database languages, which have already been proposed to support interoperability. We describe our architectural model in terms of interconnected software components that hide their implementation behind their required and provided services A specific architectural style for interoperable databases has been generated, which is deployable within a distributed component platform available from industry.