A significant role in ensuring industrial safety in terms of protecting the interests of the employees personality belongs to the occupational safety, which is directly related to the system of preserving the life and health of the employees in the course of the work activities. Occupational morbidity associated with the effect of physical overload and overstrain of individual organs and systems occupies the second rank position in the structure of occupational pathology depending on the harmful production factor. In this regard, the current and promising direction is the development of industrial exoskeleton technologies that can protect the musculoskeletal system of an employee from excessive physical activity. At the same time, the problem that creates significant restrictions on the introduction of industrial exoskeletons in industries, both in Russia and in other countries, is the lack of an appropriate regulatory-technical base. Using the example of the activity of F48 Committee «Exoskeletons and exosuits» of ASTM, the results of the work of foreign experts in the field of standardization are presented, and the main problematic issues are highlighted. Approaches to this problem in the Russian Federation are shown, where industrial exoskeletons can represent a promising type of personal protective equipment for the musculoskeletal system, the use of which is aimed at reducing the negative influence of a harmful production factor — the severity of the labor process. It is established that when developing the regulatory-technical base regulating testing and operation of industrial exoskeletons, it is necessary to combine the efforts of specialists in the technical and biomedical profile, developers, potential consumers and representatives of the scientific and research organizations, while focusing on existing domestic developments, as well as taking into account foreign experience.


unlabeled immune sera A and B, and normal sera were obtained by DEAE-cellulose chromatography and by Sephadex G-200 chromatography as previously outlined.7 These fractions were concentrated to 10 mg/ml and used to block fluorescence by incubating them on infected and nonnal sections for 45 minutes at 25 C. This material was then washed off with PBS and the sections stained with immune conjugates. Immune serum A used conjugation circulating a non-EIA-related antigen. This conjugate stained antigen in the tubular epithelium of 12 of 24 ETA horses. Ten horse kidneys had intranuclear staining and 2 had intracytoplasmic. Conjugates from immune serum B did not stain this antigen. It was concluded from the following data that this antigen-antibody system was not related to EIA. (1) The antigen was present in 5 of 10 control horses. (2) No blocking occurred by nonlabeled EIA serum that did block EIA fluorescence. (3) EIA antigen was intracytoplasmic while this staining occurred in both nucleus and cytoplasm. (4) Preinoculation EIA sera stained this antigen. (5)


Surveillance mechanisms that monitor protein synthesis can promote rapid elimination of misfolded nascent proteins. We showed that the translation elongation factor eEF1A and the proteasome subunit Rpt1 play a central role in the translocation of nascent-damaged proteins to the proteasome. We show here that multiubiquitinated proteins, and the ubiquitin-conjugating (E2) enzyme Ubc4, are rapidly detected in the proteasome following translational damage. However, Ubc4 levels in the proteasome were reduced significantly in a strain that expressed a mutant Rpt1 subunit. Ubc4 and Ubc5 are functionally redundant E2 enzymes that represent ideal candidates for ubiquitinating damaged nascent proteins because they lack significant substrate specificity, are required for the degradation of bulk, damaged proteins, and contribute to cellular stress-tolerance mechanisms. In agreement with this hypothesis, we determined that ubc4Δ ubc5Δ is exceedingly sensitive to protein translation inhibitors. Collectively, these studies suggest a specific role for Ubc4 and Ubc5 in the degradation of cotranslationally damaged proteins that are targeted to the proteasome.


Abstract In this study the relationship between fertility and the economic utility of children is investigated by using survey data gathered in 1975–6 from an agricultural village in Western India. Fertility measures included both attitudinal variables as well as number of children and an index of contraceptive behaviour; economic utility was gauged through several measures concerning labour contributions of young children, transfers from older, non-resident children and contributions towards old-age security. The analysis indicates that no obvious association exists between fertility and economic utility. Specifically, variation in the labour contributed by children had no appreciable effect upon villagers' attitudes towards fertility, nor was it connected to actual family size. Old-age security, whether measured by attitudes of younger men or by facts relating to old men, was similarly unrelated to fertility. It is argued that the respondents have become much more aware of the costs of children (especia...


A simulation control system of streetlights is designed to adopt AT89S52 microcontroller as its core.The system can control the streetlight by detecting the car through the information transmitted into the microcontroller with optical-electrical sensor.Besides,the microcontroller can control the time to turn of or turn off.The system realizes the intelligent control,which can save electric energy and human resources.The system can come to factual control if a further study is made.


Introduction. The International Council of Nurses has had an important role in enforcing of the regulation of the occupation of the Nurse. The Council established 11 basic principles of regulation based on their importance. The aim is to present the implementation of the International Council of Nurses in Slovakia and their intentions and to Original Article 46 Clinical Social Work and Health Intervention Clinical Social Work and Health Intervention Vol. 9 No. 1 2018 Introduction Regulation Latin origin means a controlled intervention that guides the unrestrained course or maintains the values of the regulated quantity. The International Council of Nurses (ICN) participates on the course of regulating healthcare professions. Margrett M. Styles was assigned by ICN to undertake a study in the years 1983-1984 in order to provide evidence of the need to regulate the profession. Styles collected, organized and evaluated nursing data in each country. She has developed directives to approve the ICN's official position and to support Member States in assessing and developing their regulatory system. ICN proposed the first principles, principles of professional regulation. The recommendations were approved in 1985 by the Council of National Representatives of ICN (Hanzlikova, 2011). The core. ICN formulated regulatory objectives as follows: • define the profession and its members; • define the scope; • set educational standards; • set ethical standards and standards of professional competence; characterize the forms and methods of regulations of this occupation. This work also aims to analyze the legislative base of the process and refer to the importance of self-regulatory mechanisms. Our intention is to familiarize the reader with creation; development; maintenance of mandatory registration of Nurses in Slovakia. Results. Concessions, registration, certification and accreditation of people or programs are the mechanisms of regulation. Regulation of the Nurses' occupation in Slovakia takes place in the form of self-regulation or statutory regulation. The basic tool of self-regulation is the Ethical Codex, which defines the responsibility of Nurses towards people – patients and also towards practice, profession, co-workers and society. A Nurse takes on the moral commitment that she/he will observe the values and fulfil the moral responsibilities expressed in the Codex. Codex as a self-regulatory mechanism expresses the aims and values of the nursing occupation. In practice, this means that the Nurse binds herself/himself to support health, prevent diseases, recover and maintain health and ease the suffering. Statutory regulation is set by legal norms and has a form of state registration, it is governed by the government and as realized by the Slovak Chamber of Nurses and Midwives. The tool for statutory regulation is obligatory registration. Based on Law no. 578/2004 of the Codex of Healthcare Providers, Healthcare Workers and State Organizations in Healthcare § 62 section 1 – Registration is the entry of a Nurse to Register and issuing a confirmation of Registration. It is important in national and international context. In a national context, it defines who and under what conditions are eligible to work as a Nurse. In international context, it conditions the ability to find employment on the international labor market. Registration is mandatory in Slovakia since 2004. 47 Original Articles Clinical Social Work and Health Intervention Vol. 9 No. 1 2018 • create a system of responsibilities; • create verification (screening) procedures. How is a profession defined and who is a professional? In the years 1987-1992, ICN realized an international project in more than 80 countries. The aim of the project was to ensure that ICN's objectives for regulatory regulation were put into practice. The result of ICN's activities was that in 1992 the World Health Organization (WHO) identified five regulated health professions (Physician, Dentist, Pharmacist, Nurse and Midwife). By adopting a WHO resolution, nursing has become one of the regulated professions. It was determined that a Nurse is a Nurse practicing nursing and is registered in the Register of Nurses. A Nurse is a person a professional who carries out the set of activities related to the provision of nursing care on the condition that he/she has acquired professional competence for practicing the profession (Act 311/2002 Coll.). What is the scope of the Nurse in Slovakia? The scope of the Registered Nurse is in implementation of practical activities a) in the provision of nursing care, b) in nursing education, c) in the management and provision of primary, secondary and subsequent nursing care by the nursing process. A Nurse works to the extent that she/ he knows how to identify deficits in the patient's needs; design and realize procedures to meet those needs; maintain nursing documentation; evaluate nursing care results. It follows that a Nurse acts in a nursing practice that is standardized; means cooperation with other members of the multidisciplinary team involved in the planning, provision and evaluation of nursing care. Training standards are set in the training for the profession. This third principle of ICN in Slovakia is implemented in such way that the legislation establishes the criteria of professional competence in the Nurse's profession. In accordance with the Government Regulation of the Slovak Republic no. 296/2010 Coll., the professional qualification for the performance of professional work activities, a Nurse acquires by obtaining the higher education degree in the study of a qualified General Nurse (lasting at least three years), higher education of the first degree in the bachelor study program in the field of study of Nursing (lasting at least 4,600 hours of which theoretical teaching represents at least 1/3 of the lessons and practical at least 1⁄2 lessons) or higher education of the 2nd Degree in the Master's Degree Program in Nursing. The professional qualification for the performance of certified work activities is obtained through certification training in certified work activities. The education standard defines that theoretical teaching of students is the part of the lessons to acquire the knowledge and professional skills necessary for organizing, planning, providing and evaluating comprehensive nursing care. It is carried out at colleges, universities and is run by pedagogical staff who are professionally qualified to perform professional work in the Nurse's profession. Theoretical lessons must be balanced with practical lessons. Practical lessons are a part of student education on the basis of which they acquire the skills to plan, provide and evaluate nursing care in direct contact with a healthy or ill person or community. They learn practical skills to lead and organize nursing care, including the education of the person, family or community. Teaching is done in hospitals and other healthcare institutions, under supervision of professional staff who are professionally qualified to practice professional nursing activities. Students are involved in providing healthcare. These conditions are created to learn how to assume responsibility for nursing care. The objective of establishing ethical standards was implemented by ICN by adopting 48 Clinical Social Work and Health Intervention Clinical Social Work and Health Intervention Vol. 9 No. 1 2018 a Nurse Ethical Code. The International Code of Ethics for Nursing was adopted by ICN in 1953 and revised in 1969, 1973, 1989, 2006 (Novotny, Novotna, Rybarova, 2017). The Code emphasizes professional behavior that is consistent with ethical principles. This means that if one becomes the Nurse, she/ he takes a moral commitment to respect the values and fulfil the moral obligations expressed in the Code. Plevova and colleagues (2011) believe that Nurses manage their own profession by respecting the Principles of the Code of Ethics. Slovak Nursing and Nurses have their own Code of Ethics, which is published as Annex to Act No. 311/2002 Coll. about the Nurse's profession, about the position of the Midwife, about the Nursing Commission and the Nursing Assistants. The Code of Ethics defines four basic responsibilities of the Nurse: • promoting health; • preventing illness; • recovering and maintaining health; • relieving suffering. At the same time, it establishes four characters principles that correct the standards of behavior. The "Nurses and People Principle" states that the professional responsibility of a Nurse is to provide the required care. Providing nursing care, Nurses promote environmental protection; respect human rights; values; customs; religious convictions of a person, family, and community. The "Nurses and Practice Principle" states that Nurses have a personal responsibility of nursing practice and maintain professional competence through lifelong education. A Nurse in nursing care is responsible for the safety of care, care for dignity and respect for patients' rights. The "Nurse and Profession Principle" states that a Nurse takes on professional responsibility to implement professional roles in clinical practice; management; research in the education process. The "Nurses and Co-workers Principle" assumes building and maintaining positive interpersonal relationships in clinical practice. The Code of Ethics expresses the objectives and values of the person a Nurse who performs the profession. Standards of professional competence are defined as follows: a Nurse who has acquired professional competence in the performance of professional work activities is authorized to carry out the professional work associated with the provision of nursing care. A Nurse who has acquired professional competence to perform specialized work activities is authorized to perform it independently within the scope of an accredited specialization study program. A similar standard of professional liability also ap


In this article with a poetic flavour,Ma.FU Shan described a kind of food called "Lianshan",which was made of oats planted in the northern rural areas of Shanxi.Because FU Shan often ate it at his hometown and felt it very delicious,he wrote this essay to extol it.People in the northern Shanxi still eat this kind of food today,but it is no longer called "Lianshan".


The problem of multiple interpretations of meaning in the indexing process has been mostly avoided by information scientists. Among the few who have addressed this question are Clare Beghtol and Jens Erik Mai. Their findings and findings of other researchers in the area of information science, social psychology, and psycholinguistics indicate that the source of the problem might lie in the background and culture of each indexer or cataloger. Are the catalogers aware of the problem? A general model of the indexing process was developed from observations and interviews of 12 catalogers in three American academic libraries. The model is illustrated with a hypothetical cataloger's process. The study with catalogers revealed that catalogers are aware of the author's, the user's, and their own meaning, but do not try to accommodate them all. On the other hand, they make every effort to build common ground with catalog users by studying documents related to the document being cataloged, and by considering catalog records and subject headings related to the subject identified in the document being cataloged. They try to build common ground with other catalogers by using cataloging tools and by inferring unstated rules of cataloging from examples in the catalogs.


In this thesis, we propose a framework that uses multiple-domains and multi-modal techniques to disambiguate a variety of natural human input modes. This system is based on the input needs of pervasive computing users. The work extends the Galaxy architecture developed by the Spoken Language Systems group at MIT. Just as speech recognition disambiguates an input wave form by using a grammar to find the best matching phrase, we use the same mechanism to disambiguate other input forms, T9 in particular. A skeleton version of the framework was implemented to show this framework is possible and to explore some of the issues that might arise. The system currently works for both T9 and Speech modes. The framework also includes potential for any other type of input for which a recognizer can be built such as graffiti input. Thesis Supervisor: Larry Rudolph Title: Principle Research Scientist


The amount of molding material to be filled into each cavity can be properly controlled, the molding method capable of simultaneously forming a plurality of high-quality molded article with one shot of the molding process, mold, molded article and and to provide a molding machine. As mold closing step of a mold apparatus filling the molding material into the mold device in a plurality of cavities starts before the end, the complete filling of the molding material before the end as the mold closing step, ends as the mold closing step after perform mold clamping process of the mold apparatus, while controlling the amount of molding material filled into the cavities, to mold the molded article.


In this paper we find a new bound for the function g(h), for which |A(G)|p ≧ p n whenever |G| ≧ p g(h) G a finite p-group. The existence of such a function was first conjectured by W. R. Scott in 1954, who proved that g (2) = 3. In 1956 Ledermann and Neumann proved that in the general case of finite groups g(h) ≦ (h – 1)3.-p n−1 + h [10]. Since then, J. A. Green, J. C. Howarth and K. H. Hyde have reduced this bound considerably. The best (least) bound to date for finite p-groups was obtained by K. H. Hyde [9]. He proved that for h ≧ 5 and g(h) = h + 1 for h ≦ 4. For finite non-abelian p-groups, we improve this bound to: for h ≧ 13, g(h) = 2h – 5 for 5 < h ≦ 8, g(h) = h for h ≦ 5 and for 8 < h ≦ 12 we prove that g(9) = 14, g(10) = 17, g(11) = 20, g(12) = 23.


In MANET, when a node is compromised it tends to reveal the other node's key information and corrupts the whole network. The scalable method of cryptographic key management (SMOCK) proposes a method to deal with such node compromise attacks. But it has certain main drawbacks such as over dependent on centralized server and increase in key-pair when node increases. To deal with these drawbacks, we present an enhanced hierarchical key management scheme using a stable and power efficient cluster management technique. Each cluster head retains the public key of its member nodes only and act as a router when dealing with nodes of other cluster members. Using this technique, the overhead on centralized server is reduced. Moreover, the need of each node storing all public keys are diminished thus minimizing the storage overhead on each node. By Simulation results, we show that our proposed scheme achieves better delivery ratio and resilience with reduced delay and overhead.


The present study was first motivated by the industrial problem of the Liquefied Natural Gaz storage tank where the stratification between two different LNG layers could be destroyed by the increasing unstable thermal stratification. Then the choice was to reproduce the historical experiments of Turner with a thin stratified interface separating two homogeneous media mixed by oscillating grids. Comparisons between thermally or salinity stratified experiments exhibit the strong dependence of the flux on the molecular diffusivity. A phenomenological model is proposed for these transfer with a clear serial scheme which is different from the previous parallel ones. It gives a clear understanding of the influence of the molecular diffusivity on the flux across those density interfaces.


Prior studies have produced models to predict metabolic rates based on experimental observations of isolated muscle contraction from various species. Such models can provide reliable predictions of metabolic rates in humans if muscle properties and control are accurately modeled. This study aimed to examine how muscle-tendon model calibration and metabolic energy models influenced estimation of muscle-tendon states and time-series metabolic rates, to evaluate the agreement with empirical data, and to provide predictions of the metabolic rate of muscle groups and gait phases across walking speeds. Three-dimensional musculoskeletal simulations with prescribed kinematics and dynamics were performed. An optimal control formulation was used to compute muscle-tendon states with four levels of individualization, ranging from a scaled generic model and muscle controls based on minimal activations, to calibration of passive muscle forces, personalization of Achilles and quadriceps tendon stiffnesses, to finally informing muscle controls with electromyography. We computed metabolic rates based on existing models. Simulations with calibrated passive forces and personalized tendon stiffness most accurately estimate muscle excitations and fiber lengths. Interestingly, the inclusion of electromyography did not improve our estimates. The whole-body average metabolic cost was better estimated using Bhargava et al. 2004 and Umberger 2010 models. We estimated metabolic rate peaks near early stance, pre-swing, and initial swing at all walking speeds. Plantarflexors accounted for the highest cost among muscle groups at the preferred speed and was similar to the cost of hip adductors and abductors combined. Also, the swing phase accounted for slightly more than one-quarter of the total cost in a gait cycle, and its relative cost decreased with walking speed.


An equivalent lever method used in analvzing automatic transmission(AT) planetary gear set was introduced.The principle and application of the lever analyzing method was discussed in delail,and the double planetary gear set was analyzed by using the equivalent lever method.A simple calculation methods for torque and speed of planetary gear set were obtained.


The minimization of losses through a simultaneous network reconfiguration (NR), capacitor placement (CP) and distributed generation (DG) allocation under varying loading conditions is a hybrid large-scale optimization problem, which requires high computational efforts, especially in large distribution systems. To reduce the complexity, load variations are not considered in most of the previous work in this area, although neglecting load variations may reduce accuracy and result in sub-optimal solutions. This paper presents a new and efficient approach for modelling load variations in a large-scale coordinated NR, CP and DG optimization problem. The presented modelling approach is illustrated on several test networks, demonstrating its accuracy, short computational times and simple implementation, compared to conventional peak demand based models and model with a detailed formulation of variable loading conditions.


Transport, including railways, is one of the main sources of noise, with a particularly strong negative impact on the environment, and on the health of children and adults. Train noise depends on the types of trains, track-type driving, driving speed and driving mode. Noise levels also depends on the rotation of the wheels on the track and on the short track wheel beats connections. The results of measurements showed that urban rail noise analyzed in the residential area is a serious problem, which needs addressing various organizational and technical measures. It was found that the rail transport caused equivalent and maximum noise levels of 20 m from the railway in the residential area were approximately 20 dB above the permissible noise levels. During the day, noise tests exceeded the permissible levels in nearly 80 % of all measurements. At night, the noise levels exceeded allowances on each of all noise level measurements. Statistical analysis of the results showed that the noise level is dependent on the train type and distance to the railway track.


1 2 Magnesium (Mg) homeostasis is critical for maintaining many biological processes, but little 3 information is available to comprehend the molecular mechanisms regulating Mg concentration 4 in rice (Oryza sativa). To make up for the lack of information, we aimed to identify mutants 5 defective in Mg homeostasis through a forward genetic approach. As a result of the screening of 6 about 3,000 M2 seedlings mutated by ion-beam irradiation, we found a rice mutant that showed 7 reduced Mg content in leaves and slightly increased Mg content in roots. Radiotracer Mg 8 experiments showed that this mutant, named low magnesium content 1 (LMGC1), has decreased 9 Mg influx in the root and Mg translocation from root to shoot. The MutMap method identified 10 7.4 kbp deletion in the LMGC1 genome leading to a loss of two genes. Genome editing using 11 CRISPR-Cas9 further revealed that one of the two lost genes, a gene belonging to RanBP2-type 12 zinc finger family, was the causal gene of the low-Mg phenotype. Considering this gene, named 13 OsRZF1, has never been reported to be involved in ion transport, the phenotype of LMGC1 would 14 be associated with a novel mechanism of Mg homeostasis in plants. 15 16


Achieving optimal therapeutic and cosmetic results in dermatological surgery often requires that procedures be carried out in a number of stages. The treatment of acne scarring is an excellent example of this strategic approach.1

Simultaneous procedures include, but are not restricted to, treatment of the following: (a) keloids, with surgical debulking and injection of intralesional steroids; (b) acne scars, with spot CO2 laser resurfacing and punch excision, floating or grafting; (c) acne scars, with autologous fat transplantation and full face CO2 laser resurfacing; (d) leg spider veins, with microsclerotherapy and vascular laser treatment; (e) wedge excision of lower lip tumours and CO2 laser vermillionectomy.2

Sequential procedures include, but are not restricted to, treatment of the following: (a) acne scarring, with punch excision, floating and grafting followed later by full face CO2 laser resurfacing; (b) congenital naevi (epidermal or melanocytic), with serial surgical excision or use of tissue expanders; (c) surgical scars and full thickness skin grafts followed later with CO2 laser resurfacing; (d) periorbital ('crows' feet') wrinkling with CO2 laser resurfacing followed later with Botulinum toxin injection; (e) two stage interpolation flaps for reconstruction of complex defects following Mohs surgery.


Biosourced phenolic foams (BPFs) based on lignin alkaline liquor and tannins were successfully synthesized without using formaldehyde and any blowing agent. The influence of three sorts of catalysi...


The paper explores the main nature and characters of the cold war and basic geopolitical, economic, information, military, ideological, cultural and other reasons, which determinedthe US, NATO and in general victory of the International Democratic Community over communist block and USSR during the "cold war", which played the decisive role for thestrengthening international security and further enlargement of democracy in the different regions of the World.Keywords: Globalization, International Banks, International Business, Trans National Corporations,trade


— Three forms of oxygen exist in the atmosphere : O, 0 3 and 02 , with increasing stability. The 0 2 photodissociation by solar UV and elementary reactions lead to a steady state abundance of atomic oxygen and ozone. In 1930, Chapman treated the oxygen chemistry in the N2, 0 2 atmosphere. Bates and Nicalet have, twenty years later, introduced the role of hydrogen compounds activating in the mesosphere the stabilization of O and 03 . In 1975, Crutzen and Johnston drew attention on the catalytic role of odd nitrogen and in 1973, Stolarsky and Cicerone have introduced chlorine an other stabilizing agent. The key reactions will be presented as well as a review of the theoretical and experimental work on the subject. L'AZOTE NON APPARIÉ ET LES AUTRES STABILISATEURS DE L'OXYGÈNE ATMOSPHÉRIQUE


Beginning with the current state of competition in English Theological Education Institutes (TEIs), which is mirrored on both sides of the Atlantic, this multidisciplinary article introduces an initial theological reflection into competition by considering history, social theory and theology and by looking through the lenses of sport, schools and business. The competitive climate that has emerged within Anglican TEIs over the last few centuries is observed by considering an historical overview. That climate is then discussed in terms of social theory using Michael Porter's Competitive Strategy and then with the insights of theology. The way forward is discussed with awareness of how a Christian theology of theological education must include a theology of competition. The aim is to open a discussion rather than to answer the question, though various theological leads are suggested.


A neurilemoma occurred in the trachea of a 63 year old woman complaining of dyspnea. Microscopically, the excised tumor was composed prodominantly of cellular areas of Antoni type A tissue and had a peripheral lymphoid cuff. The schwannian origin was confirmed both immuno‐histochemically and ultrastructurally. This tumor without nuclear palisading and Verocay bodies differed somewhat from a conventional soft tissue neurilemoma and closely resembled a particular form of neurilemoma of the stomach, previously reported as a unique entity. Thus, this type of neurilemoma does occur in sites other than the gastrointestinal tract. Acta Pathol Jpn 39:407 412, 1989.


This chapter contains sections titled: Introduction SONET Frames Virtual Tributaries STS-N Frames Maintenance Summary This chapter contains sections titled: References


Hypertension is one of the leading causes of cardiovascular disease-related morbidity and mortality globally. Over the last several decades, there has been a broad shift in the management and pharmacologic treatment, specifically of hypertension, from a step-care approach to an individualized approach, and now to a population-based approach to increase the control rate of hypertension with the overall goal of decreasing major cardiovascular events related to poor control of hypertension. The Global HEARTS initiative of the World Health Organization and the HEARTS in the Americas Program of the Pan American Health Organization, in addition to the efforts of other organizations, serve as a blueprint for the implementation of a standardized, population-based approach to treating hypertension in the primary health-care setting. We have implemented components of such a program in our primary care clinic and resistant hypertension clinic here in Columbia, South Carolina, U.S. While the U.S. is a high-income country, the demographics of our clinic is one of low income and health literacy and our population is primarily black and Hispanic, female, and of an older age. Our clinic has successfully applied population-based treatment principles on an individualized basis to improve hypertension control rates and cardiovascular disease in our local community.


0.25 /spl mu/m GaAs MESFETs are shown to be excellent device candidates for low current, low noise receiver circuits in personal communicators. The measured low current performance of ion-implanted 0.25 /spl mu/m gate FETs is reported for device gate widths of 100 /spl mu/m and 200 /spl mu/m and device bias conditions 0.5 V<V/sub ds/<1.5 V and 0.2 mA<I/sub ds/<5 mA. The 0.25 /spl mu/m/spl times/200 /spl mu/m device achieved a noise figure of 0.69 dB and associated gain of 12.4 dB at 2 GHz while drawing 1 mA of drain current. The matching characteristics and equivalent circuit models of these devices under low current bias conditions are also discussed.<<ETX>>


The liver is the largest visceral organ in the human body, performing many hundreds of functions that are critical for life. It is the site of metabolic processes, nutrient synthesis and storage, regulatory activities, and pathogen and xenobiotic defense processes. Models that recapitulate liver physiology are essential for predicting drug metabolism and toxicity as well as for understanding and treating diverse forms for disease. This chapter covers the utility and shortcomings of in vivo and in vitro liver models, with a focus on 3D models that mimic aspects of liver structure.


Objectives: To determine the diagnostic value of 256 MDCT in the diagnosis of coronary artery disease in patients with atrial fibrillation.Materials and methods: We prospectively enrolled 48 patients with atrial fibrillation who underwent 256 MDCT coronary CT angiography scan at Huu Nghi Hospital from 07/2020 to 07/2021 and evaluated diagnosis value of this technique using invasive coronary angiography as golden standard.Results: At patient-based analysis, sensitivity, specificity, positive predictive value and accuracy are 100%, 83.3% and 83.3%, respectively. At vessel-based analysis, sensitivity, specificity, positive predictive value, negative predictive value and accuracy are 98.4%, 81.7%, 80.3%, 98.5% and 88.9%, respectively. At segment-based analysis sensitivity, specificity, positive predictive value, negative predictive value and accuracy are 96.7%, 93.8%, 78.4%, 99.2 % and 94.4%, respectively. "Conclusion: 256 MDCT coronary angiography scan is a diagnostic method with high accuracy in diagnosing coronary artery disease in patients with atrial fibrillation.


Transient receptor potential vanilloid receptor 4 (TRPV4) is a calcium‐permeable non‐selective cation channel that has recently been implicated in numerous physiological functions. In this study, we investigate the ventilatory effect of a novel and potent TRPV4 agonist GSK1016790A and further explore the potential involvement of bronchopulmonary sensory neurons. Our results show: 1) in anesthetized rats, right‐atrial injection of GSK1016790A evokes a slow‐developing, long‐lasting rapid shallow breathing; it also significantly potentiates capsaicin‐evoked chemoreflexes; 2) the alteration in ventilation induced by GSK1016790A is prevented by cutting or perineural capsaicin treatment of both vagi, indicating the involvement of bronchopulmonary afferent neuron activation; 3) stimulating and sensitizing effects of GSK1016790A are abolished by TRPV4 antagonist GSK2193874 and also by systemic infusion of COX inhibitor indomethacin; 4) in patch‐clamp recordings, GSK1016790A does not activate isolated bronchopulmonary sensory neurons, nor does it modulate capsaicin‐evoked TRPV1 current in these neurons; and 5) abundant TRPV4 expression is found in alveolar macrophages as well as in vascular endothelial and alveolar epithelial cells. Collectively, our results suggest that GSK1016790A regulates respiration through an indirect activation of bronchopulmonary sensory neurons, likely via its stimulation of other TRPV4 expressing cells in lungs and airways. (Funded by Medcen Community Health Foundation, Mercer University School of Medicine and NIGMS)


In this paper we have analyzed IUE high resolution spectra of the central star (BD+602522) of the Bubble nebula. We discuss velocities of the different regions along the line of sight to the bubble. We find that the Bubble Nebula is younger (by a factor of 100) than the exciting star suggesting that either the bubble is expanding into an inhomogenuous interstellar medium or that the mechanics of the stellar wind are not fully understood.


To determine diagnostic cytomorphologic features of malignant fibrous histiocytoma (MFH) on fine‐needle aspiration (FNA) materials, we reviewed the cytologic material and corresponding histologic slides of 95 tumors in 71 patients. Forty‐four (46%) tumors were primary, 38 (40%) were recurrent, and 13 (14%) were metastatic. Histological variants of MFH were as follows: 52 (54.7%, 43 patients) were of the storiform/pleomorphic, seven (7.4%, five patients) were giant cells, four (4.2%, four patients) were inflammatory, and 31 (33.7%, 19 patients) were myxoid type. Review of original cytology reports showed that only 23 (24.2%) tumors were diagnosed as MFH and 68 (71.6%) as other types of malignancies. Four (4.2%) cases were reported as unsatisfactory/suspicious. Our findings showed that spindle‐shaped, round, giant cells, osteoclastic‐like giant, and inflammatory cells were the most consistent features that allow identification of the storiform/pleomorphic, giant cell, and inflammatory variants of MFH. The myxoid tumors had marked myxoid background matrix with spindle‐shaped cells and, less frequently, round and giant cells. Pleomorphic leiomyosarcoma and dedifferentiated liposarcoma should be considered in the differential diagnosis of stroriphorm/pleomorphic, giant cells, and inflammatory variants of MFH. However, myxoid MFH may resemble their leiomyosarcoma and liposarcoma counterparts. Diagn. Cytopathol. 2003;29:320–326. © 2003 Wiley‐Liss, Inc.


I am offering a slightly different perspective today, one that is from the 'center', from the heart of the UN System Chief Executives Board for Coordination. Let me speak about this, before I turn to the issue of UN relations with civil society. The CEB is a unique body of the multilateral system. It brings together, under the chairmanship of the UN Secretary-General, the Executive Heads of the Specialized Agencies, Funds and Programmes as well as the World Bank, the International Monetary Fund, International Atomic Energy Agency and the World Trade Organization, to develop joint approaches to major programme and management issues. As such, CEB serves to enhance the value of multilateralism, seizing the opportunities and overcoming existing challenges and concerns for a multilateral approach at the national, regional and global levels. The level of ambition and political impact of CEB is related to the specific issues under its consideration, and varies from information-sharing among Executive Heads to brainstorming on emerging issues or to collective decision-making related to intergovernmental priorities. The individual mandates and governance structures of member organizations need to be recognized and respected. CEB is not a parallel decision-making system to that of governing structures in each organization. It is rather a mechanism that helps organizations work towards common goals, as they implement their own mandates. The challenge for a highly diversified and complex group of more than two dozen organizations is to transform what could appear as fragmentation into a source of strength. This requires a continuing, systematic effort to harness the different capacities and comparative advantages of each organization in a collective endeavour to advance common objectives. The opportunities CEB takes for a system-wide approach derive from multilateral platforms, such as the Millennium Development Goals and other Internationally Journal of Civil Society Vol. 4, No. 2, 161–163, September 2008


The climate – energy project bill, voted in the House of Representatives in 2009, has undergone many changes since it is studied by the Senate. Discussions have been slowed by health reform in 2010 and then by the oil spill in the Gulf of Mexico. The midterm elections are perceived as a new obstacle in the further discussions and a possible vote on a bill in the coming months. Opponents highlight the economic constraints of such law while the United States is experiencing the most severe economic recession. Many politicians thought mainly of their re-election and opinion polls project a defeat for the Democrats. Optimists hoped for a quick vote on a bill focusing on the oil spill and a larger bill could passed after the elections. Pessimistic are unfortunately thinking that a climate energy bill will never pass, even if it could represent a major shift in energy policy of the United States with measures related to the development of renewable energy, clean technology. ... and can create the first carbon market.


Summary Tissue thromboplastin injected into the femoral vein of anesthetized rabbits produced intravascular clotting in the vessels through which the thromboplastin flowed. In the systemic arteries macroscopically visible clots were never observed. No trace of tissue thromboplastin could be demonstrated in blood drawn from the carotid artery following infusion of tissue thromboplastin into the femoral vein. The slight, transient enhancement of coagulation of the arterial blood following tissue thromboplastin infusion was caused by a serum effect. After intravenous injection of serum, enhanced activation of coagulation could be observed for a period of up to 2 hrs. It is concluded that tissue thromboplastin, intravenously injected, is removed from the blood during its passage from the femoral vein to the systemic arteries, probably in the capillaries of the lung. True hypercoagulability appears to be due to a serum effect or caused by partial activation of the intrinsic coagulation system. The levels of coagulation precursors in blood are of minor significance.


Poster: "ECR 2010 / C-1910 / The role of ultrasound-guided fine-needle biopsy of thyroid nodules, using the capillary sampling technique and onsite cytology assessment in specimen adequacy and number of needle passes " by: "M. G. Gkeli, A. N. Chalazonitis , V. Kartsouni, S. Apergis, N. Galiatsatos, S. Manouvelou; Athens/GR"


A total of 21 maps were produced that together form a type of atlas of the Nokia Mobile Data Challenge. Like in a traditional geographic atlas, we present a limited number of base map configurations, onto which various thematic elements are then overlaid. Two of those base maps are derived from MDC data, the third is placed in geographic space. Thematic overlays serve several purposes, including elaborating different elements from which the base map geometry had been derived, as well as linking other data to the base map.


A procedure based on the results of a stress-dependent finite-element computer model and used to calculates the resilient response parameters of conventional flexible pavements subjected to traffic loads is presented. Flexible pavements composed either of a granular based protected by a surface treatment or of an asphalt-concrete surface layer and a granular based are considered. Asphalt-concrete surface-layer thickness, based thickness, modulus of elasticity of the asphalt concrete, and subgrade resilient modulus at the break point (the input data required to calculate the resilient response parameters) are discussed. The basis of a flexible pavement design process for secondary roads is proposed. (Author)


The ideals generated by the minors of matrices whose entries are linear forms are not yet well-understood, unless the forms themselves satisfy some strong condition. One has a wealth of information if the matrix is generic, symmetric generic or Hankel; here we tackle 1-generic matrices. We recall the definition of 1-genericity introduced in [E2] by Eisenbud: Let F be a field and X1, . . . , Xs be indeterminates over F . Let M be an m× n matrix of linear forms in F [X1, . . . , Xs], with m ≤ n and s ≥ m + n− 1. By a generalized row of M one means a non-trivial F -linear combination of the rows of M . By a generalized entry of M one means a non-trivial F -linear combination of the entries of a generalized row of M . M is said to be 1-generic if every generalized entry is non-zero. Generic, symmetric generic, Hankel matrices, as well as many others are all 1-generic. In this wider context, however, the only case of determinantal ideals fully understood is that of the ideals generated by the maximal minors. In fact, in [E2] it is proved that these ideals are prime. However, when one considers ideals generated by non-maximal minors, patterns get complicated by the fact that often these ideals are not prime.


In this article, we get solutions of some integral inequalities of Hermite-Hadamard type and using the approach of ($\psi$,$h$)-Convex function by the way of Riemann-Liouville Fractional integrals and Katugampola Fractional integral operators.


Eleven in-whorl insecticide treatments at Highland Rim Experiment Station (HRES) in Springfield, Tenn., and 12 insecticide treatments at the Tobacco Experiment Station (TES) in Greeneville were evaluated for first-brood European corn borer (ECB) control. 'Pioneer 3147' corn was planted on 15 Apr. Plots were 3 rows × 15 ft at HRES and 4 rows × 30 ft at TES. Rows were spaced 38 inches apart. Treatments were replicated 4 times and arranged in a randomized complete block design. Blocks were separated by 5-ft alleys. Plant population was 44 plants/30 row-ft. At HRES, insecticides were applied on 9 Jun, when 85% of the plants were infested (average 4.1 larvae/plant) and at TES on 10 Jun, when 70% of the plants were infested (average 1.4 larvae/plant). Granular insecticides were applied with shaker jars. Liquid formulations were applied using 2.5-gal compressed-CO2 sprayers at 30 gal/acre and 30 psi. Whorls with new damage were counted on 29 Jun at HRES and on 25 Jun at TES. Grain yield was measured on 17 Sep at HRES (14.06% moisture). Grain yield was not measured at TES. Stalk feeding counts (tunnels/10 stalks) were made on 21 Jun at HRES only. Soil type at HRES was Dixon silt loam and at TES was Minvale-Landisburg silt loam.


A compact planar microstrip UWB bandpass filter is proposed. It is realised by cascading a lowpass filter and a highpass filter. A transmission line with U-shaped slots coupled with two DGS units on the back of the circuit board has the characteristic of highpass, while a periodic uniform DGS array has the characteristic of lowpass. Combining these two structures, a new UWB bandpass filter (BPF) is fabricated and measured. Measured results show that the proposed BPF has wide bandwidth from 3.0 to 10.9 GHz, all the measured return loss less than 13 dB in the passband. The BPF achieves a wide stopband with 18 dB attenuation up to 18.0 GHz.


The current study investigates word equivalence in selecting twenty works of fiction that have been translated from English into Kurdish by twenty different translators from 2003 to 2021. The year 2003 is historic for the Kurdistan region. The Kurdish language was marginalized under Saddam Hussein's regime. Since 2003, the Kurds in Iraqi Kurdistan have established several institutions and associations ranging from Kurdish book publishing houses, printing houses, and research centres, including tens of independent writers and translators with their intellectual individual and group projects. These developments have ultimately progressed the Kurdish vernacular language. By employing Newmark's (1988) paradigm of translation procedures, the paper shows how Kurdish translators translate words. Newmark introduced sixteen translation procedures ranging from transference, naturalization, cultural equivalent, functional equivalent couplet and notes. By examining and verifying used facts and examples derived from the selected texts, this research discovers that the process of translating from English to Kurdish faces the barrier of word-level non-equivalence. Therefore, the paper also identifies the techniques of through translation, transference and couplet as most commonly employed in the studied corpus, with functional and cultural equivalence strategies used less frequently in translation by Kurdish fiction translators. Thus, the research examines Kurdish word equivalence barriers and the significance of translation studies.


Geological structures often exhibit smooth characteristics away from sharp discontinuities. One aim of geophysical inversion is to recover information about the smooth structures as well as about the sharp discontinuities. Because no specific operator can provide a perfect sparse representation of complicated geological models, hyper-parameter regularization inversion based on the iterative split Bregman method was used to recover the features of both smooth and sharp geological structures. A novel preconditioned matrix was proposed, which counteracted the natural decay of the sensitivity matrix and its inverse matrix was calculated easily. Application of the algorithm to synthetic data produces density models that are good representations of the designed models. The results show that the algorithm proposed is feasible and effective.


China is one of the countries with the most serious flooding disasters. In China, above 70% of big cities, 50% of population and 75% of industrial and agricultural output value are distributed in eastern coastal areas with serious flooding. Therefore, enhancement of theoretical study and experience summarization of urban flood control is of great theoretical and practical significance. As economy is developing rapidly, urban scale is expanding fast, and urban flood control stand is promoted. Urban flood control calls for new concept and methods. This paper makes a systematic summarization of concept evolution and advanced methods concerning urban flood control at home and abroad. The concept of urban flood control has transformed from simple flood control and drainage to coexistence with and use of flood. Flood control measures have transferred form emphasis upon engineering ones to priority to both engineering and non-engineering ones, with special attention to ecological flood control, such as making full use of ecological revetment, ecological realignment of a river, multi-objective management of urban flood detention region, turning flood into resources and utilization of wetlands.


Bitumen (asphalt) oxidative aging is one of the prevalent causes of the pavement distresses which results asphalt pavement susceptibility to fatigue and low temperature cracking. Ultimately, aging of asphalt leads to pavement failure after years of usage. Environmental and financial issues raise demand of effective pavement materials recycling. However, aged asphalt materials re-usage is complex and specific. The idea of the research is to insert nanomaterials to aromatic rejuvenators for aged bitumen mechanical and physical properties regeneration. There are different types and chemical composition nanomaterials as products for new bitumen modification, this research focus on aged bitumen regeneration and prolonging the whole service-life of asphalt. This paper presents comprehensive literature analysis and explicit design of experiment subjected to bitumen (asphalt) ageing, rejuvenation and bitumen regeneration using nanomaterials. This innovative research allowed investigating the phenomenon of asphalt rejuvenation using nanomaterials and identifying the most appropriate rejuvenating additives in asphalt binder.


Significance Onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) are neglected tropical diseases that cause severe disability and affect more than 157 million people globally. Current control efforts are hindered by the lack of a safe macrofilaricidal drug that can eliminate the parasitic adult nematodes safely. A clinically validated approach for delivering macrofilaricidal activity is to target the Wolbachia bacterial endosymbiont of the causative nematodes. This first-in-class and highly potent and specific anti-Wolbachia preclinical candidate molecule, AWZ1066S, has the potential to significantly impact current global onchocerciasis and lymphatic filariasis elimination programs and reduce elimination time frames from decades to years. Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the lack of a safe drug that can kill the adult filaria (macrofilaricide). Previous proof-of-concept human trials have demonstrated that depleting >90% of the essential nematode endosymbiont bacterium, Wolbachia, using antibiotics, can lead to permanent sterilization of adult female parasites and a safe macrofilaricidal outcome. AWZ1066S is a highly specific anti-Wolbachia candidate selected through a lead optimization program focused on balancing efficacy, safety and drug metabolism/pharmacokinetic (DMPK) features of a thienopyrimidine/quinazoline scaffold derived from phenotypic screening. AWZ1066S shows superior efficacy to existing anti-Wolbachia therapies in validated preclinical models of infection and has DMPK characteristics that are compatible with a short therapeutic regimen of 7 days or less. This candidate molecule is well-positioned for onward development and has the potential to make a significant impact on communities affected by filariasis.


Objectives:To observe changes of intestinal mucosa morphology and proliferation after infection.Moreover, to observe influence of growth hormone on intestinal mucosa proliferation. Methods:Intra abdominal infection model was induced by cecal ligation and puncture and continuous intravenous nutrition was followed by transjugular intracaval catheterization.Experimental rats were divided into four groups:control,TPN control and TPN plus sepsis growth hormone,TPN plus sepsis groups.Changes of mucosa thickness,villus height,crypt depth,proliferating cell nuclear antigen(PCNA),epithelium cells proliferation index were determined. Results:Rat intestinal mucosa appears to have an obvious tendency to atrophy,proliferation of epithelium cells are markedly inhibited in TPN.During sepsis states,all above changes became worse.Growth hormone promotes growth of intestinal mucosal cell,improves proliferation of epithelium cells and expression of mucosa PCNA. Conclusions:During sepsis,intestinal mucosa appears to become atrophy,proliferation of mucosal epithelium cells markedly decreases.Growth hormone accelerates proliferation of intestinal mucosa epithelium cells and lightens mucosa atrophy.


Ultrashort optical pulses applied to ferromagnets excite spin polarized electronic distributions far from equilibrium (which are often referred to as "hot electrons"). Such an ultrashort-pulse excitation can lead to demagnetization, but also to a loss of electronic spin polarization due to hot-electron transport in and out of ferromagnetic layers. I will present some of our work on both topics starting with a microscopic study of the of electron-phonon and exchange scattering dynamics in a two-sublattice model with itinerant electrons. I will also present results on spin-dependent transport [3] of optically excited hot electrons in ferromagnet-metal heterostructures which have gained interest as THz emitters in recent years. The numerical solution is achieved using a Particle-In-Cell approach to treat both transport and scattering effects in a numerically efficient way that is based on ab-initio input and can be easily adapted to different structures. If time permits, I will briefly discuss a microscopic model of the inverse Faraday effect. In the framework of a ferromagnetic Rashba system with a band gap, one can compute the complete switching dynamics including spin-orbit coupling, mean-field ferromagnetism and the effect of off-resonant optical fields/pulses.


This paper presents a novel microwave bandpass filter using microstrip slow-wave open-loop resonators and multilayer liquid crystal polymer (LCP) technologies. The new filter has not only very compact size due to the slow-wave effect, but also exhibits a ultra-wider upper stopband resulting from the dispersion property. A five-pole microstrip filter of this type, i.e., a bandpass filter centered at fc=1.18 GHz with −3dB fractional bandwidth of 17%, has been designed and fabricated. No spurious response, which are at least 30-dB rejection, occurs for the frequency up to 10GHz. Moreover, the fabricated filter also has the compact size of 0.102λg × 0.081λg and the light weight less than one gram by using multilayer LCP circuit technology. Good agreement can be observed between the simulation and measurement.


Calculation of the area of affected scalp in androgenetic alopecia is desirable before injecting platelet‐rich plasma (PRP) or another drug to optimize the amount injected per square centimeter area of affected scalp. In addition, before hair transplantation if recipient scalp area is calculated, it is easier to estimate the number of grafts to be harvested. In alopecia areata, for prognostic significance, area of patches needs to be calculated. Use of graph paper and different mobile applications has been described in literature by one of us.[1] However, using graph paper is time‐consuming and mobile applications are not compatible with every smart phone.


PURPOSE: An apparatus and a method for manufacturing a manganese oxide-titania catalyst are provided to reduce the number of manufacturing processes by synthesizing the catalyst based on a chemical vapor condensation method. CONSTITUTION: An apparatus for manufacturing a manganese oxide-titania catalyst includes a vaporizing part(100), a carrier gas supplying line(200), an oxygen supplying line(300), a reacting part(400), and a collecting part(500). The vaporizing part vaporizes manganese precursors and titanium precursors. The carrier gas supplying line supplies carrier gas to the vaporizing part. The carrier gas carries the vaporized precursors to the reacting part. The oxygen supplying line supplies oxygen supplying sources to the reacting part. The reacting part reacts the vaporized precursors and the oxygen supplying sources to synthesize a manganese oxide-titania catalyst. The collecting part condenses and collects the synthesized catalyst.


Injection of normal human blood constituents into neonatal rabbits resulted in immunologic tolerance to those constituents. Subsequently, the rabbits were immunized with a series of injections of buffy coat from patients with granulocytic leukemia. Tests of these rabbits' serum were done in Ouchterlony plates, and in most cases, showed a response to buffy coat from patients with acute myelogenous leukemia, without a comparable response to normal human buffy coat. Skin tests generally confirmed the Ouchterlony plate findings. It appears that buffy coat from patients with acute myelogenous leukemia is adequate both for inducing heterologous antibody formation, and for combining with such antibodies in the test situations used. On the other hand, buffy coat from patients with chronic myelogenous leukemia appears to be adequate only for inducing heterologous antibody formation, but not for combining with such antibodies in the test situations used. Some of the implications of these observations are discussed.


This paper provides new probabilistic guarantees for recovering the common support of jointly sparse vectors in multiple measurement vector (MMV) models. In recent times, Bayesian approaches for sparse signal recovery (such as sparse Bayesian learning and correlation-aware LASSO) have shown preliminary evidence that under appropriate conditions (such as access to ideal covariance matrix of the measurements or certain restrictive orthogonality condition on the signals), it is possible to recover supports of size (<inline-formula><tex-math notation="LaTeX">$K$ </tex-math></inline-formula>) larger than the dimension (<inline-formula><tex-math notation="LaTeX">$M$</tex-math> </inline-formula>) of each measurement vector. However, no results exist that characterize the probability with which this can be achieved for a finite number of measurement vectors (<inline-formula><tex-math notation="LaTeX">$L$ </tex-math></inline-formula>). This paper bridges this gap by formulating the support recovery problem in terms of a multiple hypothesis testing framework. Chernoff-type upper bounds on the probability of error are established, and new sufficient conditions are derived that guarantee its exponential decay with respect to <inline-formula> <tex-math notation="LaTeX">$L$</tex-math></inline-formula> even when <inline-formula><tex-math notation="LaTeX"> $K=O(M^2)$</tex-math></inline-formula>. Our sufficient conditions are based on the properties of the so-called Khatri–Rao product of the measurement matrix and reveal the importance of a sampler design. Negative results are also established indicating that when <inline-formula><tex-math notation="LaTeX">$K$</tex-math></inline-formula> exceeds a certain threshold (in terms of <inline-formula><tex-math notation="LaTeX">$M$</tex-math></inline-formula>), there will exist a class of measurement matrices for which any support recovery algorithm will fail. Using results from the geometric probability, we characterize the probability with which a randomly generated measurement matrix will belong to this class and show that this probability tends to 1 asymptotically in the size (<inline-formula> <tex-math notation="LaTeX">$N$</tex-math></inline-formula>) of the sparse vectors.


A new hybrid with high ornamental characteristics,Alpinia hainanensis 'Shengzhen',derived from the generation of the hybrid combination of Alpinia hainanensis K.Schumann,was bred by using hybrid breeding.The female parent with milky white bracteoles was collected from Guangdong in 1975 and the male parent with rose pink bracteoles from Guangxi in 1983.The hybrid is better than the parents in ornamental characters and adaptability,such as tufted leaf shoots,long inflorescences,pink bracteoles and long blooming period,etc.,which is of high value in landscape architecture.


Solid state shear milling(S~3M) was successfully applied to prepare polypropylene(PP)/(BaTiO_3) nanocomposites potentially for dielectric applications.Scanning electron microscopy(SEM)(analysis) of the fracture section of PP/BaTiO_3 composites revealed that the fine ceramic particles were well dispersed in polymer matrix without assistance of any surfactant.The incorporation of BaTiO_3 greatly enhanced the dielectric constant of polypropylene.SEM of powdery specimens indicated that the strong shear and compression forces as well as friction that the pan mill exerted can(effectively) pulverize viscoelastic matters and result in microns level,or even nanosize particles.These actions also induced significant structure changes in the polymer phase during milling process,(resulting) in considerable intimacy as well as strong interaction between the polymer and inorganics,which was also confirmed by TGA and FT-IR analysis.So S~3M is a promising strategy for design of highly dispersed nanocomposites,especially for these systems with high inorganic filling.


The author of this article discusses Kazimierz Bartoszynski's didactic activity and writings, i.e. his doctoral thesis titled O powieściach Fryderyka Skarbka [On Fryderyk Skarbek's Novels] (which was published in 1963) and his later articles on the gaweda (i.e. a story stylized as an oral tale) and historical novel (which are collected in the volume titled O polskich prozach powieściowych – slynnych i nieco zapomnianych [On Polish Prose Novels – Those Famous and Slightly Forgotten Ones] (2011)). These writings were a continuation of the studies of the 19th-century novel thathad been conducted in Poznan.


There have been discovered personality features of the offenders who are placed in a special school of a closed type for underage children; the article presents "the social portrait" of the contemporary teenagers who have committed crimes or administrative offences. It is shown, that the teenagers who have not adapted (after less than 6 months of imprisonment time) to the new conditions of everyday life activities show high anxiety, difficulties in activities, unsociability, social passivity, propensity to increased introspection, complexity in social adaptation, whereas the "adapted" children (having been in prison for more than 22 months) are characterized by stress resistance, activity, working capacity and spontaneity of behavior.


The report gives results of a review of the performance and operating experience of existing utility scrubber systems and the state-of-the-art in design of scrubber components. It also gives guidelines for the design of the optimum wet scrubber system, based on this review. The U.S. EPA's Industrial Environmental Research Laboratory, Research Triangle Park, North Carolina, is considering a demonstration of an optimum wet scrubber system for use on a coal-fired utility boiler. The optimum wet scrubber system has such design goals as maximum particulate collection, low power consumption, and low maintenance.


In global healthcare and point-of-care diagnostics there is an increasing request of medical equipment with devices able to provide fast and reliable testing for clinical diagnosis. In developing countries that lack of adequate facilities, this need is even more urgent. Lab-on-a-Chip devices have undergone a great growth during the last decade, supported by optical imaging techniques more and more refined. Here we present recent progresses in developing imaging tools based on holographic microscopy that can be very useful when applied into bio-microfluidics. Digital Holography (DH) is label-free, non-invasive, potentially high-throughput and, above all, quantitative. We show the recent advancements of DH in transmission microscopy mode, when this is applied to microfluidics to yield 3D imaging capabilities. Holographic flow cytometry through quantitative phase imaging and in-flow tomography for the analysis and manipulation of micro-particles and cells will be shown [1-3]. Medical diagnostic applications based on DH will be also shown. Moreover, we present a portable common-path holographic microscope embedded onboard a microfluidic device that paves the way to the application of DH on the field [4].


This paper presents results for field scale
seawater intrusion simulations along the
Pimpama coastal-plain using SALTFLOW.
The simulations incorporated groundwater
extraction and sea-level-rise, along with a
sensitivity analysis for three physical forcings.
The three physical forcings studied in the
sensitivity analysis included variations in;
freshwater inflow, sea-level-rise and
groundwater extraction.
The field site selected to perform the field
scale seawater intrusion simulations was the
Pimpama coastal-plain, which is located
between Brisbane and the Gold Coast in
South-East Queensland (see Figure 1). The
region is undergoing significant population
growth and is an area of hydrological interest,
since groundwater extraction is relied upon to
provide water for domestic and agricultural
supply. In addition to land use change, further
stresses will be placed upon the Pimpama
aquifer due to a predicted sea-level rise, whilst
population growth should lead to a
concomitant rise in groundwater extraction.
Whether the extraction of groundwater from
the Pimpama aquifer is sustainable for meeting
future water use needs is a significant resource
supply problem and as yet no attempt has been
made to assess the sustainability of
groundwater extraction in this area. Thus, the
simulations performed in this study represent
the first attempt to assess the sustainability of
groundwater extraction for the Pimpama
coastal-plain, in light of the stresses of sealevel-rise,
and a potential seawater intrusion.
The SALTFLOW package was selected for the
simulation of seawater intrusion for the
Pimpama coastal-plain. Preliminary work
tested the computational, physical and other
modeling attributes for a suite of packages, as
well as the performance of each package
against benchmark problems from the
literature. Ultimately, the SALTFLOW
package was selected over PDE2D and SUTRA due to the ease with which time
varying boundary conditions for groundwater
flow could be incorporated into the model. Use of time varying boundary conditions for
groundwater flow enabled the effect of sealevel-rise
to be incorporated into the model.
The model also considered the effect of
groundwater extraction on future groundwater
Chloride concentrations for the Pimpama
coastal-plain. The field scale simulations
suggest that a serious seawater intrusion is
predicted to occur near the coastal boundary of
the Pimpama coastal-plain over the next
twenty years.


The last quarter of a century has featured a surge in interest and studies on
 the commons, spearheaded, of course, by the efforts of Elinor Ostrom. These
 efforts have problematized the once well-established paradigm of the tragedy
 of the commons most clearly described by Garrett Hardin in 1968. One could
 say that the commons, thus, have become a fundamental field of study in most
 social sciences. This is not the case in the field of legal scholarship
 (with one noticeable exception that I will discuss later), which leads me to
 the overarching issue of this essay, namely the difficult relationship
 between jurists and the commons. The phrase "difficult relationship" does
 not refer to an explicit antagonism, but to something even worse: complete
 indifference and a scandalous lack of knowledge. While my main purpose is to
 try to explain this sorry state of affairs, I also hope to make a more
 general point on the nature of law and legal change. In this sense, the
 commons can be considered a case-study in legal theory. The main issue of
 this paper is to tackle following sub-questions. What is the status of
 commons in the Western European legal discourse? Why do most legal scholars
 pay such a poor attention to the growing literature on the commons in other
 disciplines? What factors contribute to this peculiar case of cultural
 deafness? What promise of improvement does the future hold?


The free radical polymerization of a series of compounds having the general formula

in which Y was F, Cl, Br, I, NO2, and CN has been studied. The compounds were found to vary markedly in polymerizability. An explanation is advanced in which it is postulated that chain transfer involving a substituent in the allylic position of the monomers is the controlling factor in determining their polymerization behavior.


An efficient method for the synthesis of 6-vinylindazolo[3,2-a]isoquinolines via rhodium(III)-catalysed C-H bond activation/subsequent [4+2] cyclization starting from easily available 3-aryl-1-H-indazoles and propargyl alcohols has been developed. A series of vinyl-annulated...


String matching is one of the fundamentals in various text-processing applications such as text mining and content filtering systems. This paper describes a fast string matching algorithm using a compact pattern matching machine DAWG. A directed acyclic word graph (DAWG) is traditionally implemented with a 2-dimensional linked list or matrix. However, DAWGs with these structures have drawbacks, the lookup time of the linked list based one is slow and the space requirement of the matrix based one is large. Therefore, this paper proposes a novel DAWG based on a compacted double-array, which overcomes the drawbacks of traditional ones. Experimental results show that the novel DAWG is more efficient than traditional ones.


I The Background of Renaissance The awakening of Bengal in the l9th century is a fascinating subject on which a number of published scholarly works arc available. The role played by Bengal in the modern awakening of India was, with some apparent exaggeration, compared by Prof. Susobhan Chandra Sarkar to &dquo;the position occupied by Italy in the story of the European Renaissance&dquo;.1 How this awakening-though limited and stunted from its very inception―spilled over almost simultaneously to other neighbouring i',~rts of India reinains however an untold story. The pu;pose of this paper is to show how Assam


A simulation of a five-level sinusoidal pulse width modulation (SPWM) rectifier fed D.C motor is proposed. The proposed topology of a five-level rectifier can be regulate the output voltage using (SPWM) to obtain variable speed of a D.C motor with constant load torque. The main advantages of the SPWM rectifier system are to drive a D.C motor with constant and variation load torque, low harmonic distortion in A.C supply side. The PID speed controller is used to make constant speed when load torque increase or decrease about 20% of rated value and to improve the dynamic response of the system. The five-level SPWM rectifier fed separately excited D.C motor are studied and simulated under the MATLAB/SIMULINK program.


The invention provides a method for producing electrodeposited nickel. Anode liquor generated in the electrodeposition process is used as a raw material. The content of Ni2+ is larger than or equal to 75 g/L, the content of Cu2+ is smaller than 0.001 g/L, the content of Fe2+ is smaller than 0.001 g/L, the content of Co2+ is smaller than 0.001 g/L, the content of Pb2+ is smaller than 0.0002 g/L, and the content of Zn2+ is smaller than 0.0002 g/L. The pH of the anode liquor is made to reach 2.5-3.5 after diffusion and dialysis of special negative ions, so that the anode liquor serving as electrodeposition catholyte enters an electrodeposition tank to produce the high-quality electrodeposited nickel; due to the fact that small granules which are not completely filtered, residual oil and organisms in the electrodeposition catholyte are adsorbed onto a plate surface, purification of the catholyte is achieved to a certain extent, and after acid modulation, a solution meets the production requirement of the electrodeposited Ni9996.


TFrom the technological process and economic benefits,the article analyzes the application of direct drinking water in residential quarters,discusses the problems in application of direct drinking water, and brings forward relative advice.


In a screw mounting structure of an injection molding machine in which a screw is fixed to a screw driving portion which transmits a rotating force and forward and backward thrusts to the screw, a fixing bushing for restricting movement of the screw in a rotating direction is fixed to the screw driving portion. A guide groove is formed in the fixing bushing in a direction orthogonal to a rotary axis of the screw, and retainers slide along the guide groove and are engaged with an engaging groove in a base portion of the screw, thereby restricting axial movement of the screw.


Today's fast-paced, connected world can be dangerous for teens, and parents naturally desire to protect their children like a momma bear protects her cubs.


2523Background: Anaplastic gliomas are classified according to the presence of IDH-mutation. IDH wild type (IDH wt) is associated with poor prognosis and limited effectiveness of treatments.The aim...


According to the characteristics of higher vocational education,together with the need of practice,this article points out that it is necessary to optimize teaching content and process by changing teaching method and adopting modern educational technology in an elaborate design of classroom teaching.Meanwhile,great importance should be attached to the practice after class,so as to foster students' integrative competence and improve the quality of teaching.


With the popularization of vehicle artificial intelligence technology, safe driving technologies such as vehicle collision avoidance have gradually attracted people's attention. Aiming at the problem of anti-collision of smart vehicles, this article uses monocular vision to determine the position of the target vehicle in the front and back, so as to calculate the distance between the host vehicle and the target vehicle, and give an early warning of possible collisions. The precaution mechanism promptly reminds the driver of dangerous situations, provides the driver with reliable anti-departure instructions and anti-collision warning signals, and is supplemented by sound and light alarms. This paper studies key technologies such as algorithms and early warning schemes for locating roads and vehicles in front, and gives preliminary test results to verify the feasibility and effectiveness of the anti-collision early warning system.


points out that Moldovan and his students did not criticize eventual racist rhetoric and legislation, even though they claimed scientific objectivity. Bucur makes a convincing case that the eventual interdiction of marriage and the anti-Semitic legislation relied on imported foreign models, especially from Germany, although they were not imposed from outside. Romania produced its own internal racist xenophobes, but they did not generally come from the eugenics movements. This is a fine distinction to make, and it reflects Bucur's study of the extensive published literature of the day, supplemented by archival documents. The result is a significant contribution both to the comparative history of eugenics as well as to the social and intellectual history of Romania between the wars.


The present situation of natural conservation management at county level is introduced,the management problems are analyzed briefly,the countermeasures to strengthen management are put forward.


Electrospray ionization Fourier transform ion cyclotron resonance (ESI-FTICR) mass spectrometry is a rapidly emerging, universal platform with the ability to provide detailed information regarding genetic variation and the up- and down regulation of their cognate gene products. Herein, we report our progress towards the development of ESI-FTICR mass spectrometry for the characterization of genomic regions which contain both a length and sequence polymorphism (i.e., complex short tandem repeats). Specifically, it is demonstrated for the first time that a high-quality ESI-FTICR mass spectrum of a 82-bp double- stranded PCR product derived from a single, 50 (mu) L PCR reaction with less than 10 X 10-15 moles injected into the mass spectrometer can be routinely obtained. It is important to note that each measurement, which translates to an accurate genotype, is completed on the timescale of seconds. Progress towards the implementation of flow- injection analysis methodology to increase the throughput is also presented using an alternating injection of a 15-mer and 16-mer oligonucleotide.


Since the beginning of the financial crisis – yet unfolded ten years ago – policy makers and researchers have devoted remarkable attention to Corporate Governance (CG) and its issues. Indeed, the crisis highlighted the importance of adopting best practice policies, at the corporate level, in order to improve the efficiency of the governance structures and, thus, a company's reputation. In particular, our chapter aims at providing the main changes that characterized the Italian CG system during the last ten years. Although smalland mediumsized enterprises (SMEs) represent the backbone of the Italian economy, we focus our study only on listed companies. We do so not only because listed firms present a more organized system of CG, but also because the main CG reforms have been especially addressed towards them. The chapter is structured as follows: Section 1.9.2 presents the main regulatory changes that occurred in the previous years. Section 1.9.3 provides insights into ownership structures and M&As. Section 1.9.4 deeply scrutinizes the characteristics of the Board of Directors (BoD) in Italy. The remuneration system, instead, is analysed in Section 1.9.5. Section 1.9.6 provides information on shareholders' rights, while Section 1.9.7 offers details about the corporate social responsibility of Italian listed firms. Section 1.9.8 provides information on the link between CG and a company's performance. Finally, Section 1.9.9 offers the main conclusions.


1 Signed into law by President Obama on March 23, 2010, the Patient Protection and Affordable Care Act, Pub. L. 111-148, 124 Stat. 119, amended the language of 31 U.S.C. § 3730(e)(4), but Graham Cnty. Soil & Water Conservation Dist. v. United States ex rel. Wilson, 130 S. Ct. 1396 (2010) concluded that the change is not retroactive. See 130 S. Ct. at 1400 n.1. Thus, the prior version of the statute applies to the present dispute. UNITED STATES OF AMERICA et al v. ITT EDUCATIONAL SERVICES, INC. Doc. 318


According to the World Health Organization, the prevalence of obesity worldwide has nearly doubled between 1980 and 2008.
The overall objective of this study was to identify the correlation between abdominal obesity or waist-hip ratio as a predictor of changes in the metabolism of employees of a company in Lima, Peru, during the period January-February 2014. The study included 298 of which 213 were men and 85 women. The average age of the population was 52 ± 9.7 years.
The problems of overweight and obesity increase with age, reaching the highest rate in the age group 45-59 years (42.9%). In the age group over 60, is a percentage of 22% with overweight and obesity.
According to the Spearman correlation is a direct association between very closely waist circumference and triglycerides (CP = 0.063; p =
0.276) was found.

The implementation of effective preventive strategies based on these findings, it can prevent heart disease in this population.


The contribution provides a brief summary of a new book devoted to some faces of the knowledge society written by an international collective of authors lead by the author of this contribution. The goal of the book is to present some among the most important — at least according the opinion of it authors — aspects of the roles of knowledge in the emerging knowledge society.


In the 1980s, communities around the country began to realize that hazardous wastes from households and small businesses continued to contaminate the municipal solid waste (MSW) stream. While large generators of hazardous waste were under increasing regulations to handle the wastes from cradle to grave, households and very small business generators were not subject to the stringent regulations. Consequently, local communities recognized the need to provide disposal options to households and small generators in order to keep the hazardous wastes out of the landfills, sewers, incinerators, and even deserts of the community. The city of Tucson, Ariz., and Pima County created the Household Hazardous Waste Collection Program (HHWCP) in the late 1980s and implemented the Small Business Waste Assistance Program (SBWAP) in May 1994 to address these needs. In the first three years of operation, HHWCP has collected more than 500 tons of hazardous materials from households in Pima County and directed these wastes to reuse, recycling, or disposal facilities away from the Pima County and Tucson landfills, sewers, and deserts. Over 22,000 participants have used the collection sites, and HHWCP has presented lectures and discussions to many groups and schools in the community. The target audience of SBWAP ismore » the conditionally exempt small-quantity generator (CESQG). SBWAP works as part of, and in conjunction with, the general program for residents. SBWAP was conceived to help very small businesses. Only businesses that generate very small quantities of hazardous waste may participate in the program. Specifically, a business must be a CESQG.« less


This article is devoted to study foreign experience of formation of national digital infrastructure onsocial research. The object of the study is the national digital infrastructure on social research in GreatBritain and the countries of the European Union, the subject is the organizational and economic relationsthat are developing in the process of their formation and functioning. The study was conductedon the basis of a system-structural and functional approach using generalization, systematization andinduction methods. The information base of the study are the roadmaps for the formation and developmentof digital research infrastructure in the UK and European Union countries. During the study,there were identified the tendencies in social sciences development in the context of digitalization,there was shown the variety of digital research infrastructures in the field of the humanities and socialsciences, there were analyzed the digital infrastructure on social research at the country and regionlevels, there were identified the factors affecting on formation and development of national digitalinfrastructure on social research. The findings of study results can be used to determine the prioritydirections for the development of the Kazakhstan's national model of digital infrastructure on socialresearch.


Brake judder is a kind of low-frequency brake vibration and noise phenomenon generated during braking. Various types of judder have been reported, depending on the particular generation mechanism. However, the correlation between the microstructure of gray iron brake discs and judder has seldom been discussed in the literature. In this research, the effect of the microstructure of a gray iron brake disc on judder was investigated using a single end full dynamometer. Judder propensity was evaluated by measuring BTV (brake torque variation), and the effect of cell counts of eutectic gray iron on the friction surface of the brake disc was also measured in the circumferential direction. The eutectic cell counts were controlled by changing the machining thickness of the friction surface. Results showed that the microstructure of the gray iron disc played a crucial role in controlling brake vibration during braking. In this work, reduction in the eutectic cell counts resulted in less brake torque variation, suggesting more stable brake performance. †(Received April 10, 2017; Accepted July 7, 2017)


Claims 1. A sustained release preparation comprising: a polymeric tube, a gel composition that is directed to insects such pests in the polymer tube, the composition comprises one or more volatile substances and a gelling agent, wherein said one or more volatile substances comprise in an amount of from 70.0 to 99.0% by weight of the gel composition is directed to insect pests type and released out of the polymeric tube through the polymeric tube. Claim 2: The sustained release preparation according to claim 1, wherein said one or more volatile substances are selected from the group consisting of a substance containing pheromone, an attractant and repellent. Claim 3: The sustained release preparation according to claim 1 or 2, wherein said gelling agent is selected from the group consisting of an amino acid derivative, a higher fatty acid chain, a polyvalent metal salt of a fatty acid long chain saccharide derivative and wax.


This work is dedicated to the theoretical analysis within the framework of a comprehensive study of the verbalization of the concept LANGUAGE POLICY. Some aspects of the analysis of the nominative field and nominative space are presented. The definition of the phenomenon of nominative space is not often found in scientific studies, it is usually compared with the phenomenon of nominative field or equated to it. The vast majority of works are dedicated to the establishment and study of the nominative field of the concept. It is necessary to compare the theoretical component of the phenomena of the nominative field and the nominative space, as well as provide its own definition of the phenomenon of the nominative space.


Design and synthesis of amide-linked ferrocene-fulleropyrrolidine oligomers is presented, with initial characterisation that confirms products containing three or four ferrocene-bridged fullerene u ...


A new view of the problem of continuing a given segment of the spectrum of a finite object is presented. Based on this, the problem is restated in terms of reducing a defined 'error energy' which is implicit in the truncated spectrum. A computational procedure, which is readily implemented on general purpose computers, is devised which must reduce this error. It is demonstrated that by so doing, resolution well beyond the diffraction limit is attained. The procedure is shown to be very effective against noisy data.


Liver abscesses occur in finishing cattle fed high-grain, low-roughage diets. Cattle with abscessed livers do not show any clinical signs and are detected only at slaughter. Liver abscesses, which account for 67% of all liver abnormalities in cattle slaughtered in the United States, are of major economic concern to the beef industry. Fusobacterium necrophorum, Trueperella pyogenes, and Salmonella enterica, particularly the serotype Lubbock, are the main etiologic agents. Currently, the control of liver abscesses is based on in-feed use of antibiotics. The emergence and dissemination of antimicrobial resistance to antibiotics use in animals is a public health concern. Plant-based phenolic compounds, called phytophenols, are known to have antimicrobial properties. Our objectives were to evaluate antimicrobial activities of phytophenols on the liver abscess bacterial pathogens. Phytophenols extracted from rosemary, green tea, grapeseed, organic goji berry, and green coffee were selected for testing. The phytophenols were extracted using 75% aqueous acetone and total phenolic content was determined by a spectrophotometric analysis. Bacteria were cultured in Mueller-Hinton broth (S. Lubbock and T. pyogenes) or anaerobic brain-heart infusion broth (F. necrophorum with and without phytophenols, at 6, 12, 24, and 48 hours and bacterial concentrations were determined. If phytophenol was inhibitory, a micro-broth dilution method was used to quantify the inhibition. Phytophenols from green tea, grape seed, and rosemary inhibited T. pyogenes. Further studies are ongoing to investigate different concentrations of phenolic compounds on the pathogens. Phytophenols that inhibit the pathogens may have the potential to be used as feed additives to prevent liver abscesses.


Clean energy power generation, mainly wind power, photovoltaic, and thermal power generation, is developing rapidly. The problem of joint output dispatching of multiple clean energy power generations connected to the grid at the same time needs to be solved urgently. Considering that Concentrating Solar Power(CSP) has good dispatchability and controllability, it can be used as a dispatching measure to suppress the random fluctuations caused by grid-connected wind power and improve the utilization rate of wind power. A combination of Wind power-Photovoltaic power-Thermal power-Concentrating Solar Power is proposed. Joint optimal scheduling model of clean energy considering CSP regulation. This model stabilizes the fluctuations caused by the wind power and photovoltaic power grid connection by changing the thermal storage / exothermic heat generation time of the CSP and adjusting the thermal power output power, and improves the wind power and photovoltaic power utilization rate, making the joint output more stable, but the scheduling measures cannot be unlimited due to cost constraints. To regulate. In order to make the joint output after scheduling both stable and economical, this paper sets the joint output optimization scheduling model with the goals of the lowest comprehensive dispatch cost and the smallest joint output power variance, and solves it with differential evolution for multiobjective optimization algorithm(DEMO). The pareto-optimal set is calculated based on the fuzzy membership function. The satisfaction of the optimal solution concentrates the decision vector, and the one with the highest satisfaction is the optimal compromise solution. Finally, an example simulation calculation was performed using a power grid in northwest China. The results show that the proposed joint optimal scheduling model can effectively improve the grid-connected utilization rate of wind power, and the combined output power is stable and the dispatching cost is economic.


CD8+ cytotoxic T cells are key players in anti-cancer immune responses as they destroy MHC class I-dependent tumor cells. Therefore, the spatial distribution of CD8+ cytotoxic T cells might represent an important surrogate for the response to cancer immunotherapy including immune checkpoint inhibitor therapy ICT. The radiolabeled minibody [89Zr]Zr-Df-IAB22M2C is characterized by a high affinity to human CD8 and was already investigated in a phase I study. Here, we present our first experience with the non invasive in vivo assessment of the whole body CD8 T cell distribution in cancer patients using clinical [89Zr]Zr-Df-IAB22M2C PET/MRI. In total 8 patients with metastasized cancers (5 x malignant melanoma; 1 x choroidal melanoma, 1 x NSCLC and 1 x sarcoma) were studied before (n = 3) or during (n = 5) ICT. Multiparametric PET/MRI was performed 24 h after injection of 74.2±17.9 MBq [89Zr]Zr-Df-IAB22M2C (1.1 - 1.8 mg Df-IAB22M2C) on a Siemens Biograph mMR System (SiemensHealthineers, Erlangen, Germany). The whole body distribution of the [89Zr]Zr-Df-IAB22M2C tracer was analyzed with a special focus on tumors/metastases as well as primary and secondary lymphatic organs. The PET tracer [89Zr]Zr-Df-IAB22M2C was well tolerated without any reported side effects. The PET/MRI acquisitions 24h p.i. of [89Zr]Zr-Df-IAB22M2C revealed a comparably low background signal with only a minor blood pool and unspecific tissue retention. Regarding the primary and secondary lymphoid organs we observed a high interpatient variability of the tracer uptake. Four out of five patients with previous ICT exhibited a relatively high [89Zr]Zr-Df-IAB22M2C uptake in the bone marrow. Also a large number of non metastatic lymph nodes yielded a pronounced [89Zr]Zr-Df-IAB22M2C uptake in four patients. Strikingly, a low [89Zr]Zr-Df-IAB22M2C uptake in the spleen compared to the liver (liver/spleen ratio < 10) was observed in 4 out of the 5 patients with cancer progression during ICT. Interestingly, only one metastasis with an intense tracer was detected in this patient cohort. This first clinical experiences revealed the feasibility to assess potential immune-related changes by [89Zr]Zr-Df-IAB22M2C PET/MRI. Considering these results we hypothesize that the whole body distribution of CD8+ cytotoxic T-cells assessed by non-invasive in vivo [89Zr]Zr-Df-IAB22M2C PET/MRI might be associated with the response to cancer immunotherapy which needs to be investigated in subsequent prospective trials.
 Citation Format: Johannes Schwenck, Dominik Sonanini, Walter Ehrlichmann, Gabriele Kienzle, Gerald Reischl, Pascal Krezer, Ian Wilson, Ron Korn, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Ferdinand Seith, Andrea Forschner, Thomas Eigentler, Lars Zender, Martin Röcken, Bernd Pichler, Lukas Flatz, Manfred Kneilling, Christian la Fougere. Imaging of CD8+ cytotoxic T-cells by Zr-89-Df-IAB22M2C PET/MRI: First clinical experience in patients with metastatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB058.


Lymphogranuloma venereum (LGV) is a systemic sexually transmitted disease caused by Chlamydia trachomatis (C. trachomatis) L1 L2 and L3 the organism gains entrance through skin breaks and abrasions and travels via the lymphatics to multiply within mononuclear phagocytes in regional lymph nodes. The clinical presentation of LGV depends on the sex of the patient mode of sexual contact (e.g. vaginal or anal sex) and the stage of the disease. LGV is diagnosed in men up to 6 times more frequently than in women but the infected women are more likely developed to late stage. LGV is rare in China however the incidence was increasing in recent years. In this paper we diagnosed a case of LGV and confirmed this case was caused by L3 serovar of C. trachomatis by using genotype test. (excerpt)


The office market has traditionally been observed to be too inflexible to satisfy dynamic workspace demands. Market forces have continuously compressed lengths of commercial leases and new office s ...


As a developing metropolics, Beijing is facing unprecented opertunity and challenge in its urban traffic management. Especially in 2008, The Olympics will be held in Beijing, which bring Beijing traffic tremendous pressure.This paper intrduces the necessity and urgency of building dynamic information system of real-time traffic Data on road network, and put forward the whole architecture of the system in Beijing, covering the conception, basic structure, technical requirement, and the consruction engineering of the system, which relate to information collection subsystem, processing and analying subsystem, imformation issuing subsystem and the comprehesive synergia of the whole collectivity.


This article analyzed the situation of the construction of the basic courses experiment teaching demonstration centers in Shandong Province's universities,put forward that the key to do well the construction is leaders' idea and understanding,established the effort point and location point of the construction of experiment teaching centers;and made clear the development requirements and described the new thoughts about the construction.