This chapter investigates the relationship between ideas about melancholy and those about the self in the Renaissance, in order to outline the contours of the specifically 'melancholic subject.' It focuses principally on the learned discourse of orthodox Galenic medicine and Aristotelian psychology. The chapter addresses the relationships between the Galenic medical conceptions of the human subject, more general philosophical concepts of subjectivity and selfhood, and theories of melancholy in the Renaissance. It concentrates on those parts of intellectual production where a clear or significant relationship can be discerned between the medical psychology of melancholy and conceptions of what it is to be a human subject or self. The chapter also addresses some ways in which medical psychology of melancholy relates to non-medical conceptions of selfhood.Keywords:Aristotelian psychology; Galenic medicine; medicine; melancholic subject; psychology; renaissance


This study was undertaken to identify the employment status of individuals before and after spinal cord injury (SCI), the factors influencing return to work and the reasons why return to previous employment status were difficult, delayed or not achieved. The study identified when individuals were ready to address return to employment issues as well as the resources that may be required to support return to work. Postal questionnaires were sent to 242 individuals, aged 16 years and above, who were admitted to the Stanmore spinal cord injury centre (SCIC) with acute, traumatic SCI between 1998 and 2003. Forty-two percent of respondents returned to paid employment however, only 26% actually remained in employment. Reasons for non-return to or cessation of employment were primarily related to respondents' health, access to transport and training. Twenty-five percent of respondents described themselves as long-term sick, particularly those with cervical injuries. Physical intensity of work activities altered a...


In this paper,study BG distributor's principle and machinery.Distributor's three-dimensional modeling is done base on Solid Edge.BG distributor's development and characteristic is expatiateed.Analyze BG distributor's machinery and principle.Distributor's three-dimensional modeling is introduced detailedly.


With professional sports in depth,sports brokerage industry also developed rapidly.Through literature and logical method,the article inspects the current sports agent law for the management,and analysis the question of the of China's sports agent exist in development.While some foreign countries,sports agents,management and legal system for the analysis and reference,Take proposals to the Chinese sports agent management of the relevant legal system.Hoping that it will take reference for legalization and standarlization of the current sports agent law for the management.


The purpose of this study was to develop a new glove interface that can manipulate many kinds of objects in virtual space by real hand movements. This glove has the same form and material as a surgical glove, and the user's movements are unrestricted. Thus, while performing operations on a real human body, the user can control many kinds of data that are displayed in virtual space. During operations, the surgeon can handle many kinds of data, for example, synchopexia, MRI images, 3DCT images, and time sequential 3D images by using this glove.


Russian imagism, one of the four leading literary schools in Russian modernist poetry, has a niche in the history of Russian literature. It has inherited and developed some characteristics of the western European imagism. Thus, this school of poetry has evolved its own unique style of writing, governed by the idea--"Image First". It attaches primary importance to images alone, emphasizing the uniqueness of images in poems and neglecting the content. As a result, the poems are written longer, the skipping of images is getting greater and sphere of life they reflect wider.


A plane problem of aggregate redistribution in a magnetic fluid in a vessel consisting of two reservoirs, upper and lower, connected by a vertical channel is analyzed. When the channel walls are heated to different constant temperatures, a two-layer plane-parallel convective flow of magnetic fluid, which realizes an aggregate exchange between the reservoirs, develops. The redistribution of aggregates in the channel and their transfer from the lower to the upper reservoir occur under the action of the thermomagnetic, gravitational, and frictional forces exerted by the magnetic fluid and under the influence of concentration diffusion. The channel dimensions which ensure efficient transfer are estimated


ABSTRACT This article illuminates the nature of 'spirituality' as it relates to addiction in modernity. It does so by using philosopher Charles Taylor's conception of the malaise of modernity and the meta-narrative he presents in A Secular Age as theoretical starting points. It then draws from qualitative data collected through semi-structured interviews and ongoing ethnographic fieldwork conducted with Canadian millennials who self-identify as 'spiritual but not religious'. The young people's experiences of addiction provide insight into the trappings of free-market capitalist modernity and its inability to provide an overarching source of meaning to their lives. Addiction becomes the means by which these individuals experience the malaise of modernity, which in turn leads them to seek an alternative understanding of the good life—a process they equate with 'spirituality'. Therefore, an interest in 'spirituality' ought to be understood as a personalized attempt to re-enchant what is experienced as a disenchanted world.


The present project aims to expose the operation and perform analysis on the behavior of COPPE- COSENZA Model. It also provides, as an application, perform the hierarchical analysis of location for installation of a reliable internet network and stable in the lakes region, analyzing beyond the socioeconomic aspects of need for the region, factors that will support the entrepreneur so you can structure your network and allows expand it safely without affecting users, providing also a sound structure for the offering company 's service. For this, as principal methodology was used COPPE- COSENZA model of hierarchical analysis, which has its concepts based on fuzzy logic and AHP.


In the last Quarterly Technical Progress Report the authors reported the synthesis and (partial characterization) and SCR (Selective Catalytic Reduction of NO) activity for a delaminated Fe{sub 2}O{sub 3}-pillared clay (Fe{sub 2}O{sub 3}-PILC). The SCR activity for this PILC was substantially higher than that of the commercial-type V{sub 2}O{sub 5} + WO{sub 3}/TiO{sub 2} catalyst. During the past quarter, the authors first completed the characterization of the delaminated Fe{sub 2}O{sub 3}-PILC catalyst. Both physical characterization (micropore probing by adsorption and Moessbauer spectroscopy) and chemical characterization (by IR spectroscopy) were performed. Since the synthesis of this PILC sample was undertaken under a specific set of conditions and it is known that the PILC properties depend strongly on the synthesis conditions, they then proceeded to examine in a systematic manner the dependence of the catalytic properties of the PILC on its synthesis conditions. Four parameters in the synthesis were studied: Fe precursors, pH of the pillaring solution, concentration of the pillaring solution, and the starting clay. Finally, the effect of the Cr{sub 2}O{sub 3} promoter on the SCR activity of the pillar clay was studied. Results are reported.


This article is based on a real and significant didactic experience, realized in a virtual environment, in which we work the graphic design applied to the creation of visual identities from the point of view of the representation of people instead of companies or entities. Thanks to this work we have been able to apply different innovative strategies, such as gamification, for the correct development of a task that includes the acquisition of theoretical-practical knowledge, reflection on visual identity, interaction between the different members of the experience (students and teacher) and the motivation of entertainment. For a better understanding of the experience and the task, we will know the needs of which the elaboration of the didactic proposal arises, his development, the main theoretical-visual foundations in which the learning is supported and the valuation of the experience from the point of view of the teacher and from the students (participants of the experience).


Abstract Because Gen. 9:8-17 uses the word qĕsĕtin relation to the deity and to the clouds, the inference has been made in biblical scholarship that the text refers to a rainbow. The plausibility of this inference is tested in this article. Attention is given to the various linguistic aspects of this word in the Hebrew Bible and to the specific textual composition of Gen. 9:8-17 as well as to the broader ancient Near Eastern framework established by comparative literary and iconographic evidence. The conclusion is reached that the word qĕsĕtdesignates in Gen. 9:8-17 a warrior's bow which represents both the deity's might and power as well as his willingness to transfer his power over the earth to those living on it.


Positive parent-adolescent communication has been found to be negatively related to adolescent depressive symptoms; however, few studies have investigated the moderating effects of adolescent gender and age on this relationship, especially during early adolescence in China. The present study investigated the joint moderating effects of adolescent gender and age on the linkage of father-adolescent and mother-adolescent communication with adolescents' depressive symptoms. A total of 11,455 Chinese junior high school students (Mage = 14.15 years, SD = 1.22 years; 49.86% boys; Ngrade7 = 5712, Ngrade9 = 5743) completed ad hoc questionnaires of parent-adolescent communication and depressive symptoms. Multiple linear regression analyses were conducted. Results indicated that gender and age jointly moderated the association between parental communication and adolescent depressive symptoms. Specifically, for girls, the negative effects of both father-adolescent and mother-adolescent communication on depressive symptoms were stronger in 9th grade students than in 7th grade students, while for boys, the negative effects were not different between 7th grade students and 9th grade students. These findings suggest that in China, the protective effects of positive parent-adolescent communication on adolescents' depressive symptoms may be most salient among senior-grade girls in junior high school.


Background Adult-onset Still's disease (AOSD) rarely occurs in adults and no specific serological or pathological findings have ever been reported. Although multiple lymphadenopathy often develops in AOSD patients, only few reports have described their pathology so far.1,2 Objectives To examine pathological features of lymph node (LN) in AOSD patients and their usefulness in diagnosis in Japan. Methods This is a single center, retrospective study. The subjects were 115 Japanese patients who visited our department and received LN biopsy from April 2010 to July 2018. Of these, 12 patients, in whom AOSD was suspected by clinicians at the time of biopsy, were analyzed. AOSD patients were diagnosed according to the Yamaguchi's criteria3, except the item "excluding malignant lymphoma". Results The median age of the 12 cases (2 males, 10 females) was 60.5 years old (range: 18-81). Paracortical hyperplasia was shown in 7, follicular hyperplasia in 1, histiocytic necrotizing lymphadenitis (HNL) in 3, and diffuse large B cell lymphoma (DLBCL) in 1. Of 9 who fulfilled Yamaguchi's criteria, TAFRO syndrome was diagnosed in one. As for the other 8, diagnosis of AOSD was made and successfully treated as AOSD. Although 1 of the 8 had pathological features of HNL, we treated her as AOSD because her clinical feature and laboratory data were not compatible with HNL. As for the 3 who did not meet the criteria, their clinicopathological diagnosis was HNL in 2 and DLBCL in 1. We could find no associations between the clinical features and lymph node patterns in AOSD as previously reported. Conclusion In patient who fulfilled the criteria, most cases showed paracortical hyperplasia in LN as previously reported from outside Japan and no cases had malignant lymphoma. However, in diagnosing AOSD, LN biopsy is needed to exclude AOSD-mimicking malignant lymphoma especially in the case that does not fulfill the criteria. References [1] Kim HA, et al. Medicine (Baltimore). 2015;94:e787. [2] Jeon YK, et al. J Clin Pathol. 2004;57:1052. [3] Yamaguchi M, et al. J Rheumatol1992;19:424–30. Disclosure of Interests None declared


Abstract This case study explored the perceptions of choristers singing in a multicultural university choir in South Africa and the personal value they associate with their choir participation. Data were collected through semi-structured individual interviews, focus groups, and a four-month period of observations of choir rehearsals and performances. This research highlights the multidimensional experiences of choral singing which can be fulfilling, abundant, as well as demanding at times. Emergent themes include music as a key indicator leading to personal-, resilience-, and social values. Findings indicate the significance of collective music making and the ways in which it influences the lives of participants, such as enjoyment, health benefits, achievement, commitment, accountability, a sense of belonging, and camaraderie. Choristers experience the choir environment as safe and conducive to forming important relationships. Although cultural integration takes place to a large extent, there are still barriers due to a variety of languages within a diverse group of choristers. Participants' reflections reveal that choir participation is an ideal vehicle whereby social cohesion can be enhanced. Finally, the study highlights the importance of choral conductors and educators employing strategies that allow choirs within a multicultural environment to successfully transform in order to remain relevant to the needs of the singers within a diverse setting.


Nowadays, speech recognition is become more and more important. Various speech applications are available in the market. Consumer electronic devices can operate through voice. In the proposed system mobile phone is used as a controller to control whole system. In mobile phones CELP (code excited linear prediction) method is used for speech coding. CELP based speaker verification method, the CELP encoding method used for mobile phone voice communication is applied to the encoded voice data to perform speaker verification. A fuzzy c-means algorithm is used, in fuzzy clustering data point can belong to more than one cluster, and associated with each of the points are membership grades which show the degree to which the data points belong to the various cluster. FCM algorithm gives better result for overlapped data set and is comparatively better than k-means algorithm.


In 2012 the US Congress directed the Federal Motor Carrier Safety Administration (FMCSA) to improve commercial motor vehicle safety through the MAP-21 Act. NHTSA reported to the US Congress in 2015 that heavy truck rollover crashworthiness should be improved. To that end NHTSA sent a letter to the president of SAE asking if improvements in test methods could be suggested that would result in improvement of rollover performance. In this study we review the performance of heavy truck cab structures that meet the requirements of J2422 and suggest a framework for improving rollover crashworthiness for heavy trucks.


The main target of this bachelor's work is draw up a project of an improvment of city Bze-nec's economy. The theoretical part is aimed to the elucidation of the basic terms and the relations dealing with the public administration, especially the community and its costs budget, as are inco-mes and costs. Consequently on the theoretical part there was made analysis of city Bzenec's economy during period of years 2003 - 2006. For this study were used the budgets and final ac-counts, which set up to the end of each years. The analytic part is engaged in propsal of the improvment present of city Bzenec's economy and set up the future budget for years 2008 - 2009.


The cutoff wall of the dam of Huangnipu Reservoir in Xingan County is the cutoff wall of water-jetting method and high-pressure jetting grouting method. The problems encountered in the construction course of the cutoff wall are introduced. At last,the treatment measures are proposed in this paper.


The invention relates to a nuclear grade pump qualification test loop system. The loop system mainly consists of a main test loop section and a water charging system, wherein the main test loop section comprises a test pump, an extension-type cooler, pipeline exterior electrical heaters, a water storage tank provided with an electrical heating element, a pressure stabilizing tank, a venturimeter, two electric ball valves QV2 and QV3, an electrical control ball valve BV1 and a tee coupling pneumatic ball valve TV1; and the water charging system is composed of a water replenishing pipe, and the water replenishing pipe is divided into three branches which are connected with the test pump, the inlet of a circulating pump and the bottom of the pressure stabilizing tank. In the loop system provided by the invention, the main test loop and a heating cycle loop are matched together so as to finish the performance test, thermal shock test, impurity test and long duration test of the test pump, thereby realizing the localization of nuclear grade pumps.


Abstract Widespread use of the human papillomavirus (HPV) vaccine has the potential to reduce incidence from HPV-associated cancers. However, vaccine uptake among adolescents remains well below the Healthy People 2020 targets. The Centers for Disease Control and Prevention (CDC) National Comprehensive Cancer Control Program (NCCCP) awardees are well positioned to work with immunization programs to increase vaccine uptake. The CDC chronic disease management information system was queried for objectives and activities associated with HPV vaccine that were reported by NCCCP awardees from 2013 to 2016 as part of program reporting requirements. A content analysis was conducted on the query results to categorize interventions according to strategies outlined in The Guide to Community Preventive Services and the 2014 President's Cancer Panel report. Sixty-two percent of NCCCP awardees had planned or implemented at least one activity since 2013 to address low HPV vaccination coverage in their jurisdictions. Most ...


The crystal structures of two polymorphic forms of tolfenamic acid have been determined by X-ray diffraction methods. The two forms contain the molecule as different conformers. In the yellow form the planes of the two benzene rings form an angle of 46°, in the white one the corresponding angle is 73°. This difference is also reflected in the geometry of the amino group, where the yellow form exhibits a larger degree of conjugation. An analysis of the crystal structures and their physical properties suggests that the yellow form is the stable low temperature modification.


Islamic banking has existed in Indonesia since 1992. The performance of Islamic banking is interesting for further analysis. This study aims to analyze the impact of good corporate governance (GCG) implementation and bank characteristics on the performance of Islamic banking in Indonesia before the COVID-19 pandemic. Profitability is a measure of banking performance and is proxied by return on assets (ROA) and return on equity (ROE). The research sample consists of Islamic commercial banks that published financial and annual reports between 2011 and 2019. The data collection method used is documentation. Multiple regression analysis was used for data analysis. The results indicate that the implementation of GCG has no significant impact on performance (probability values of 0.425 and 0.420 on ROA and ROE with coefficients of 0.016 and 0.019). The P-value of the non-performing loans (NPF) variable is < 0.001 on ROA and ROE, which means that NPF has a significant negative impact on ROA and ROE. Third-party funds only have a significant impact on ROE with a p-value of 0.046. Meanwhile, the size of a bank has not been shown to have a significant impact on the performance of Islamic banking in Indonesia. Efforts to maintain NPF are critical for banks to achieve good performance (profitability). NPF demonstrates the risk of nonpayment of Islamic bank financing.
AcknowledgmentWe gratefully acknowledge the research funding provided by LPPM Universitas Negeri Semarang (contract number: 19.8.3/UN37/PPK.3.1/2022).


India has enjoyed a close relationship with Africa, and specifically East Africa, since its independence in 1947. Since the beginning of the 21st century, however, this relationship has only grown closer. This policy on Africa is largely to ensure India's energy independence, but also to bolster its status as a world power. The goal of Indian diplomacy is to foster a true partnership with the African countries that will promote their economic development ? but China's seeming omnipresence is threatening to thwart New Delhi's ambitions.


The percentage of S&P 500 firms using multiyear accounting-based performance (MAP) incentives for CEOs increased from 16.5% in 1996 to 43.3% in 2008. The use and design of MAP incentives depend on the signal quality of accounting versus stock performance, shareholder horizons, strategic imperatives, and board independence. After the technology bubble, option expensing, and the publicity of option backdating, firms increasingly use stock-based MAP plans to replace options, resulting in changes in pay structure, but not in pay level. While firms respond to the evolving contracting environment, they consider firm characteristics and shareholder preferences and do not blindly follow the trend.


A railway frog made of high manganese steel failed before an expected life due to spalling of the nose rail.The railway frog spalling fractograph was observed and analyzed by SEM and energy spectrum.There were a small amount of inclusions of Al_2O_3 or [Al_2O_3]·(CaO)_x in the material microstructure and a large amount of dense fatigue striation and muddy corrosion product in the surface cracks.Therefore,the spalling failure mechanism of railway frog might result from corrosion fatigue of the surface and contact fatigue of the subsurface.The fatigue cracks often initiated from the positions of inclusions or asymmetriz structures.The cracks in the surface propagated into the subsurface at a sharp angle to shear stress,and some cracks in subsurface propagated to surface.When both cracks propagated together,the spalling in surface would take place and form spalling pits.


This study is aimed to investigate the regional pressure groups' effect on
 the government size in Turkey. According to the public choice theory,
 elections, political parties, interest and pressure groups, and bureaucracy
 significantly affect the public production process. Among these actors,
 pressure and interest groups directly affect variables such as economic
 growth and public expenditures. In this study, panel data analysis was used
 to observe the regional effect. The research data set covered 81 provinces
 of Turkey and the period between 2006 and 2018. According to the results, it
 was found that interest and pressure groups increase the public expenditures
 in the less developed regions in Turkey. These results are consistent with
 the empirical and theoretical studies. For this reason, the study has an
 important contribution to the literature. This study offers significant
 conclusions that public economic policies might be under the influence of
 interest and pressure groups. Even if stated that the results of this study
 might have many economic, demographic, social, and political reasons
 regarding Turkey, in the context of public choice theory, it could be seen
 as a significant indicator of not using public expenditure policies as
 efficient instruments. This situation shows that public resources are not
 used efficiently in Turkey and the government has a negative effect on the
 economy. To eradicate this negative effect, governments coming to power in
 the future ought to produce economic, political, and social policies in
 order to decrease the regional differences dramatically in Turkey.


A 68-year-old female patient self-medicated with 1 tablet of compound paracetamol and amantadine hydrochloride (each tablet contained acetaminophen 250 mg, amantadine hydrochloride 100 mg, calculus bovis factitious 10 mg, caffeine 15 mg, and chlorpheniramine maleate 2 mg) because of nasal discharge and cough on the second day of trabeculectomy with covering of amniotic membrane in her right eye. About 30 minutes after administration, she developed dizziness, nausea, vomiting, urinary incontinence, itching on her arms and calves, and pale. Her blood pressure was 80/44 mmHg and heart rate was 90 beats/min. Anti-allergic treatments, blood volume expansion, and oxygen mask were given. Thirty minutes later, her blood pressure increased to 90/62 mmHg. The patient's symptoms gradually alleviated 2 hours later and the blood pressure increased to 106/69 mmHg 6 hours later.

Key words:
Compound paracetamol and amantadine hydrochloride; Anaphylaxis


In surgery, assemblages of imaging systems need to be managed, interfaced, and coordinated by a collocated team. In this paper, I untangle the different forms of imaging system interaction in this highly specialized multi-device environment (MDE). I show how the different forms of imaging systems affect the work practice by creating a need for additional articulation work. This articulation work is coordinated into the surgical practice on the body by either distributing the work across the team or by requiring a momentary pause of the surgical work for the entire team to attend to the articulation work to be done on or with the images. And we see how distributing the work across the team still requires a reintegration of the knowledge gleaned from the new information into the surgery itself. This presents an expansion of our understanding of how collocated teams function in MDEs that consist of purely shared displays.


Reactivation of herpes simplex virus type 1 (HSV‐1) has been implicated in the pathogenesis of idiopathic peripheral facial palsy (Bell's palsy). The present study used the polymerase chain reaction (PCR) to analyze the saliva of patients with Bell's palsy for the presence of shed HSV‐1. The study involved 47 patients with Bell's palsy, 24 patients with Ramsay Hunt syndrome, and 16 healthy HSV‐seropositive volunteers. HSV‐1 DNA was not detected in the saliva samples from HSV‐seronegative patients. The prevalence of shed HSV‐1 in patients with Bell's palsy (50%) was significantly higher than that in healthy volunteers (19%, p<0.05). When saliva samples were tested within 7 days after the onset of palsy, the prevalence of shed HSV‐1 in patients with Bell's palsy (40%) was significantly higher than that in patients with Ramsay Hunt syndrome (7%, p<0.05). Furthermore, HSV‐1 usually became undetectable by the second week after the onset of Bell's palsy when HSV‐1 was detected during the acute phase of the disease. These findings strongly suggest that reactivation of HSV‐1 is involved in the pathogenesis Bell's palsy, and indicate that PCR is a useful tool for early diagnosis of HSV‐1 reactivation in patients with Bell's palsy. J. Med. Virol. 54:162–166, 1998. © 1998 Wiley‐Liss, Inc.


1. Respiratory load compensation plays an important role in the maintenance of an appropriate level of ventilation. We investigated the ventilatory and behavioural responses to a severe load causing both hypercapnia and hypoxaemia in a rat model.


Despite the growth of embedded brands in entertainment media, few theory-based studies have assessed consumer processing of brand placements in games. This study contrasted the influence of media context (play, watch) and psychological response (telepresence) on consumer recall, game liking, and perceived persuasion for real and fictitious brands in a racing game. Results show that playing the game impeded recall, but had no effect on game liking or perceived persuasion across brands. Telepresence and game liking were positively related to perceived persuasion for real and fictitious brands, with telepresence mediating the effect of game liking on perceived persuasion for real brands. Results are explained according to cognitive capacity and media context effects. "Where have all the young men gone?" asked advertisers after reviewing television ratings for the 2003-2004 season (Shields 2005). It seems that the answer may be found in games. About 150 million people in the United States, or 63% of the popula tion, play video games (McClellan 2005), and advertisers are taking notice. For instance, Coca-Cola and McDonald's shifted dollars from broadcast to in-game advertising (Grover et al. 2004). Although representing a small proportion of overall me dia budgets, spending on advertisements in electronic games totaled $185 million in 2005 according to the Yankee Group (McClellan 2005). A Nielsen report suggested, "video games are quickly becoming the most effective medium for reaching consumers via product integration" (McClellan 2005, p. 9). The practice is poised to become a five billion dollar industry (Leeper 2004), due in part to Nielsen metrics (Gough 2004) and structured costs (Moran 2004). Despite the growth and potential of this medium, relatively little is known about how consumers process brands in this interactive entertainment context. Our research builds on an emerging body of research in the gaming context (e.g., Chaney, Lin, and Chaney 2004; Grigorovici and Constantin 2004; Lee 2004b; Nelson 2002, 2005; Ron 1996; Schneider and Cornwell 2005) and expands on two areas that offer promise for theoretical and managerial understanding. First, research demonstrates the influence of media-induced psychological re sponses such as telepresence (i.e., the sense of being transported inside a mediated environment; see Steuer 1992) on recall and persuasion of embedded brands (Grigorovici and Constantin 2004). However, studies to date have only examined the inter active task of game playing on processing. Because games offer a special form of interactivity that presents opportunities for both playing and watching, and because playing can enhance a sense of telepresence (Lessiter et al. 2001), we test the influ ence of playing or watching on respondents' telepresence and brand processing. Second, past research in the gaming environment has exam ined real brands (Grigorovici and Constantin 2004; Schneider and Cornwell 2005), fictitious brands (Chaney et al. 2004; Lee 2004b), or a mixture of real and fictitious embedded brands (Nelson 2002; Ron 1996). These latter studies reported that fictitious brands suffer on post-play memory tasks (Chaney et al. 2004; Lee 2004b; Nelson 2002). However, such studies do not generally delve into the factors that influence processing or persuasion, nor do they systematically contrast effectiveness for brands of the same products that differ in familiarity. Games contain real and fictitious brands, such as spoofs like New York Time in the Max Payne game, or brands that are perceived as fictitious because they are unavailable in certain markets (Nelson, Keum, and Yaros 2004). For instance, participants in an in-game advertising study in Australia indicated that they recalled brands such as Ralliart and Castrol because they were familiar with the brands, but they did not recall Union 76 (Schneider and Cornwell 2005). The researchers suggest that a lack of cultural awareness of U.S. brands (e.g., Union 76) influenced the results. They recommend that "the use of ficti tious brand names embedded in video games would allow the researcher more control over past brand exposure experience, Michelle R. Nelson (Ph.D., University of Illinois at Urbana Champaign) is an associate professor of advertising, University of Illinois at Urbana-Champaign. Ronald A. Yaros (Ph.D., University of Wisconsin-Madison) is an assistant professor of communication, University of Utah. Heejo Keum (Ph.D., University of Wisconsin-Madison) is an assistant professor of mass communication and journalism, Sung kyunkwan University, Seoul, Korea. Journal of Advertising, vol. 35, no. 4 (Winter 2006), pp. 87-99. ? 2006 American Academy of Advertising. All rights reserved. ISSN 0091-3367 / 2006 $9.50 + 0.00. DOI 10.2753/JOA0091-3367350406 This content downloaded from 220.127.116.11 on Thu, 26 May 2016 06:55:45 UTC All use subject to http://about.jstor.org/terms 88 ThejJournal of Advertising thus permitting an examination of the video game exposure in isolation" (p. 339). Processing differences for brands that vary in familiarity have been discussed in other types of advertising research (e.g., recall: Kent and Allen 1994; persuasion: Machleit, Allen, and Madden 1993). Yet no research to date has examined underly ing factors for processing real and fictitious brands in a game context where cognitive capacity is limited (e.g., Chaney et al. 2004). Thus, this experimental study compares effects of telepresence on real and fictitious brand recall, perceived game liking, and perceived brand persuasion effects for players and watchers. It furthers understanding of consumer processing across real-life exposure situations within a new and growing medium, extends theory on brand placement, and underscores the importance of context effects (e.g., telepresence, game lik ing) and brand familiarity for brand placement effectiveness.


INTRODUCTION Tears of the anterior cruciate ligament (ACL) are an common injury, affecting over 100,000 patients per year in the US alone [1], and reconstructions of the ligament are performed over 200,000 times a year world-wide [2]. The ACL is an important structure for knee stability, playing a vital role during normal walking patterns and pivoting motions during sports [3]. While imaging methodologies can be used to visualize the injured ligament, manual clinical examinations are necessary to determine the extent of the injury and the functional capabilities of the knee [3]. While there are numerous orthopedic clinical examinations to assess knee stability, the pivot shift test is a multiplanar maneuver shown to be the most specific diagnostic test to detect ACL tears [4]. It's lack of false positives and its high correlation to clinical and patient-reported outcomes make it the most informative clinical exam in the orthopedic surgeon's arsenal [4]. Unfortunately, the results of these orthopedic exams are subjective, limiting their use as diagnostic exams that can be compared over time and between patients and physicians. It has been found after studying the kinematics of the knee during the pivot shift maneuver that the anterior tibial translation correlates well with the clinical grade given by the physician after a positive test [5]. While devices such as electromagnetic tracking systems and visual navigation systems can be used to track anterior tibial translation during the pivot shift [6,7], these methods are extremely invasive and complex, making them inappropriate for use in a clinical setting. In order to obtain quantitave data in a non-invasive way, a 2D image analysis method has been developed at the Orthopedic Robotics Laboratory at the University of Pittsburgh to measure the anterior tibial translation during the pivot shift. The application has been tested on small quantities of patients [8], but a comprehensive assessment of how the 2D image analysis correlates to the actual 3D kinematics of the knee has not been published.


Fiona Ritchie & Peter Sabor, eds. Shakespeare in the Eighteenth Century. Cambridge: Cambridge University Press, 2012. xiii + 454 pp. $104.99 USD, £69.99 (hardback). ISBN 9780521898607.The compiling and re-editing of critical studies and of rewritings of Shakespearean work from the past have not only saved from possible oblivion a multiplicity of texts whose future was at best uncertain, but have shed considerable light on the processes by which the provincial actor, poet, and playwright was elevated to the rank of national and international icon. Addressing particularly this latter phenomenon, Shakespeare in the Eighteenth Century constructs a rich and variegated picture of how the numerous reinventions, rewritings, or reinterpretations to which he was subject in the period allowed him to achieve the "exemplary status" the volumes editors, Fiona Ritchie and Peter Sabor, attribute to him in their introduction.Most of the rediscoveries were conducted through the medium of print, and part 1 of the volume, entitled "The Dissemination and Reception of Shakespeare in Print," comprises essays on the editing, criticism, reviewing, and (that peculiarly eighteenth-century phenomenon) falsification of Shakespeare. Marcus Walsh's chapter, "Editing and Publishing Shakespeare," unpicks the fiercely competitive world of Shakespeare editing, from the first (not quite) complete-work offerings from the house of Jacob Tonson, chief commercial beneficiary of the 1710 Copyright Act, to the single-volume editions that flooded the market following the commonlaw ruling which put an end to exclusive ownership of the plays in 1774. Walsh's thesis, that editing and publishing was "a stage upon which were played out some of the most significant issues in British cultural, political and commercial history" (21), is borne out by a consideration of the work of the most serious, and also successful, actors on it (from Nicholas Rowe to Edmund Malone, through Alexander Pope, Samuel Johnson, and George Steevens). Such work, from Walsh's evolutionary perspective, is seen to gain in philological rigor, explicative clarity, and interpretative acumen as the century advances. For Walsh, the "end-point of an editorial journey" from Pope's appeal to the educated reader to the more interventionist approach of the professional commentator (35), is that of Malone (1790), whose ten-volume octavo offering, including primary documentary evidence, historical contextualization, and a "focused and selective in- terpretive method of real theoretical self-consciousness and cogency" (34), set the standards for future interventions.The importance of the editions might seem overstated here, were it not for the fact that their mere existence helped to shape, and contributed to, other distinctly eighteenth-century forms of cultural intervention, such as criticism and reviewing. What Jack Lynch, in his chapter, "Criticism of Shakespeare," describes as the "symbiotic relationship" between both entities, with critics contributing to the esteem for Shakespeare at the same time as Shakespeare contributed to the invention of the critic (41), was, he argues, largely a product of the emergence of increasingly learned editions of the works. With the editorial dispute between Pope and Lewis Theobald, prompting the latter's Shakespeare Restored (1726) and subsequent edition of the plays, the start-of-the-century obsession with the (mainly moral) imperfections of Shakespeare's work is described as developing into a more appreciative, if "hardly irenic" (44), mode of attention. Later critical efforts were thus directed at defending Shakespeare from incompetent editorial "meddlers," historicizing his use of language, social and cultural references, as well as sources, and, in a patriotic gesture, defending his disregard of French-imposed rules. But if the editions had such a profound and lasting effect on criticism, they also gave an impulse to that much neglected field of literary intervention, the book review. …


Some of the oldest (Early Devonian) fossil fish remains from Antarctica found so far are described and include spines of the acanthodian Machaeracanthus sp. and plates of an actinolepid arthrodire. A summary of the finds of Devonian fish from Antarctica recovered so far is provided. Most of them are of Middle or Late Devonian age from Victoria Land. The material reported on here is thus significant in being Early Devonian in age.


Author(s): Johnson, Parker McCormick | Advisor(s): Goulding, Celia W | Abstract: Bacteria have developed complex mechanisms to survive and propagate within their environments. Contact-dependent growth inhibition (CDI) is a recently discovered mechanism of inter-bacterial competition and communication widespread amongst Gram-negative bacteria. CDI+ cells inhibit the growth of neighboring cells upon delivery of a toxic protein (CdiA-CT) into the target cell cytosol. To prevent auto-inhibition, CDI+ bacteria express an immunity protein (CdiI) to specifically bind and inactivate cognate toxin. Here we provide further structural characterization of CDI toxin/immunity proteins to elucidate the diversity of CdiA-CT toxin activity, their potential activation, and neutralization to repurpose CDI systems for novel antimicrobials.Burkholderia pseudomallei isolates E479 and 1026b have been shown to utilize CDI to outcompete neighboring bacteria, signifying the pathway's importance in growth and survival. The CdiA-CT toxins from these isolates are functional tRNases, yet have unique tRNA specificities and cleavage sites despite sharing no sequence similarity. We have solved the X-ray crystal structure of the B. pseudomallei E479 toxin/immunity protein complex and compared it to the previously solved 1026b complex. While the toxins are sequentially and functionally different, they share significant structural homology with nearly identical active sites, only differing in active site pocket size, correlating with the differing substrate cleavage sites of the two toxins. The toxin/tRNA interactions have been confirmed via molecular docking as well as small angle X-ray scattering. The CDI system from uropathogenic E. coli 536 (UPEC536) is unusual, CdiA-CT exhibits toxic tRNase activity only when bound to target cell CysK, termed a "permissive factor", involved in cysteine biosynthesis. We have solved the X-ray crystal structure of the CysK/toxin/immunity ternary complex. The UPEC536 toxin inserts its C-terminus into the active site cleft of CysK, mimicking its natural interaction with CysE. A homologous toxin from the Gram-positive Ruminococcus lactaris has been identified to perform the same enzymatic function in a CysK-independent manner. Characterization of this toxin has shown that it's significantly more thermostable than the UPEC toxin, and is capable of binding tRNA substrate in the absence of CysK. This demonstrates a chaperone-like function for CysK, stabilizing the UPEC toxin fold and promoting its association with tRNA substrate.


Coordinated regulation of gene expression which involves activation of lineage specific genes and repression of pluripotency genes drives differentiation of embryonic stem cells. For the complete r...


Social protection is a principal device in progressing comprehensive development and, supportable and socially just development; moreover, social protection has ascended as a widespread arrangement of instruments planned to help individuals, households and communities to better manage risk, shocks and extreme poverty. The National Social Protection Strategy of Cambodia gives the particular purpose of social protection as that assists people cope with major sources of poverty and vulnerability while in the meantime advancing human development. It comprises of abroad set of arrangements and instruments intended to ensure people, households and communities against the financial, economic and social results of diverse dangers, risks, shocks and to bring them out of poverty. In Cambodia, social protection has expanded more thought since the arrival of the National Social Protection Strategy for the Poor and Vulnerable (NSPS) in 2011. The NSPS provides policy guidelines and activity arrangements to reinforce the social protection system in the country. Institutionally, the experience of a social safety net is nothing new to Cambodia, but the term and understanding might be conceptually separate. Cambodia is facing significant sources of vulnerability. The majority of vulnerable groups are children, women, people with disability, and the elderly. Poverty, growth inequality, social exclusion and lack of access to public services and opportunities are the main causes of vulnerability. This paper depicts about social protection policy of Cambodia, scope of SP, and presently facing the challenge of social protection in Cambodia; furthermore reviews on social protection framework and existing of social protection to reduce poverty that being embraced by government intervention.


a number of issues regarding Land Record Management has been pointed out in the literature. In particular, developing countries like Pakistan face severe Land Record Management issues, such as data tempering with land record, provision of no means to fetch out a complete history of property ownership, working of various related Land Record Management System in isolation, etc. Prevalent traditional Land Record Management Solutions do not address such issues. To address these issues, we propose a Blockchain-based Land Record Management solution for Pakistan. The proposed system has been designed and implemented, details of which are presented in the paper.


Objective: The diversity of thermophilic fungi in tropic area of Guangxi Province was studied.Method: The soil samples were collected in various area of Guangxi Province.The thermophilic fungi were isolated from soil samples by spread the samples on PDA plates and culturing the plates at 50℃.The fungal colonies were picked,further purified and verified at 20℃.Result: Thirty three strains of thermophilic fungi were obtained.These 33 strains were identified according to the morphological characteristics and ITS sequences.The results indicated that 20 strains were belonged to Thermomyces lanuginosus,4 strains were Thermoascus aurantiacus,1 strain was Chaetomium thermophilum,1 strain was Talaromyces emersonii,and 1 strain was Talaromyces emersonii.Six strains were not identified duo to the low similarities of the ITS sequences to the ITS sequences of the known fungi.Conclusion: The thermophilic fungi in tropic area of Guangxi Province were diversity and Thermomyces lanuginosus is the dominant species.


Preliminary studies on rats fed a diet containing 45% irradiated beef showed that weight gain was greater and food conversion was better for rats fed nonirradiated beef than for those fed irradiated beef. The hemorrhagic syndrome in rats was overcome by the addition of vitamin K to the ration. Diets containing irradiated beef or irradiated flour had no significant detrimental effects on growth, feed conversion, fertility, or lactation in dogs during a 2-yr period. (C.H.)


Enzymatic oxidation of polyphenolic compounds in damaged tissue of many fruits and vegetables induced undesirable browning as results in decreased marketability of products. A new type of polyphenol oxidase (PPO) that is "Phloroglucinol Oxidase (PhO)" have been reported in turnip and cabbage, and the purified enzymes also had strong peroxidase (POD) activity. Distribution of PPO from different plant source of cruciferae vegetables were observed. Cabbage, broccoli, turnip and cauliflower PPOs from Indonesia and Japan strongly oxidized 1,3,5-trihydroxybenzenes such as phloroglucinol (Phl) and phloroglucinol carboxylic acid, but not oxidized 1,2,3-trihydroxybenzenes and o-diphenol. On the other side, Chinese mustard, Chinese cabbage, shingensai, Japanese radish root, mizuna, takana, leaf mustard, katsuona and komatsuna also strongly oxidized 1,3,5-trihydroxybenzenes and little oxidized 1,2,3-trihydroxybenzenes such as pyrogallol and gallic acid, but not oxidized o-diphenol. These results indicated that the PPOs in all cruciferae vegetables are a group of a new type of PPO, however, the level activity of 7 varieties of vegetables from Indonesia and 15 varieties from Japan tested showed different activity level of PhO and POD.


The framework of this paper is a passive sonar system, more precisely at the core of bearing estimation and bearings-only target motion analysis (BO-TMA). A cosine of relative bearing estimation and bearings v.s. time image is first obtained by a conventional frequency-domain beam-former [D.H Johnson et al, 1993]. Computing the first two moments of each line of this image, we evaluate the likelihood of the cosine of relative bearing of the target. Then, the cosine of relative bearing and its derivative are considered as the two components of a state vector of a linear dynamic system. This state vector is then estimated (or extracted) by a classical algorithm of the hidden Markov model (HMM) arsenal, whose parameters are adjusted according to the statistical assumptions. Unlike, we consider the presence of one sole target, but the beginning and the end of the line are unknown and must be estimated too. The extracted track is used as measurements set of the BO-TMA. Finally, the confrontation of the TMA results allow us to evaluate the performance of the triplet (beam-former, bearing extraction, BO-TMA).


The nematic coupling constant α, together with the chain stiffness κ, governs chain alignment and the isotropic-to-nematic (IN) transition temperature TIN for semiflexible polymers. We combine self...


Twenty-five percent of women are physically or sexually abused, and in nearly all instances psychologically abused, by intimate partners during the course of a relationship. Walker (1979) identified Battered Woman Syndrome (BWS) as a predictable pattern of psychological response to domestic violence. During the same time period, Post-Traumatic Stress Disorder (PTSD) was identified by the American Psychiatric Association (1980) to describe the predictable effects of traumatic events. It became increasingly clear that different types of terrifying experiences, including combat, rape, torture, and childhood physical and sexual abuse, all resulted in the same basic psychological response (Herman, 1992). Nearly two-thirds of battered women experienced symptom patterns that met the diagnostic criteria for PTSD (Goodman & Epstein, 2008). By the 1990s, it became apparent that PTSD in battered women and BWS were explaining the same condition.

Keywords:

battered woman syndrome;
battered women;
domestic violence;
post-traumatic stress disorder;
Complex PTSD


A reverberation chamber is a very useful tool to obtain the radiation efficiency of an antenna. While it has been shown that the magnitude of the reflection coefficient can be obtained from these measurements as well, this has not yet been shown for the phase of the reflection coefficient. This would allow for a full characterization of the antenna's behavior as seen from its input port. In this paper it is shown that the phase of the free-space reflection coefficient can be obtained from measurements in a reverberation chamber by taking the angle of the ensemble average of the individual reflection coefficients. This has been empirically verified by comparing several sets of measurement data from the reverberation chamber to their anechoic chamber equivalents for several antennas.


In the present research, analysis and monitoring of lubricating oil as proactive tool
to heavy machinery equipment Mannucci Diesel S.A.C, which serves Antamina
Mining Company S.A. in Huaraz maintenance was performed. The goal is to
anticipate failures produced in the Volvo equipment by implementing a proactive
maintenance program that allows us to control pollution in their units and thus
increase the availability and reduce maintenance costs of the equipment of heavy
machinery.
For the procedure followed in this work, the following steps are established: list and
coding equipment heavy machinery, so that we have a record of these and identify
through a criticality analysis, which teams present failures more , of which a
sampling of oil will take place, which will be taken to a laboratory for analysis and
whose report will allow us to determine which pollutants are produced more wear
on engines so they can plan preventive maintenance and predictive that allow us to
keep track of oil contamination.
Finally, an economic evaluation was performed using comparative tables show the
benefits of the tool used, demonstrating that the proactive approach allows us to
diagnose problems in diesel engines using oil analysis, thus providing an adequate
and safe operation of their equipment in their daily activities.


Background: RAD54 performs branch migration and stimulation of RAD51 DNA strand exchange. Results: Streptonigrin inhibits branch migration through specific binding to RAD54 but spares stimulation of RAD51-mediated DNA strand exchange. Conclusion: RAD54 ATPase activity is relatively less important in the stimulation of DNA pairing than in branch migration. Significance: Small-molecule inhibitors are instrumental to study the mechanisms of RAD54 activities. RAD54, an important homologous recombination protein, is a member of the SWI2/SNF2 family of ATPase-dependent DNA translocases. In vitro, RAD54 stimulates RAD51-mediated DNA strand exchange and promotes branch migration of Holliday junctions. It is thought that an ATPase-dependent DNA translocation is required for both of these RAD54 activities. Here we identified, by high-throughput screening, a specific RAD54 inhibitor, streptonigrin (SN), and used it to investigate the mechanisms of RAD54 activities. We found that SN specifically targets the RAD54 ATPase, but not DNA binding, through direct interaction with RAD54 and generation of reactive oxygen species. Consistent with the dependence of branch migration (BM) on the ATPase-dependent DNA translocation of RAD54, SN inhibited RAD54 BM. Surprisingly, the ability of RAD54 to stimulate RAD51 DNA strand exchange was not significantly affected by SN, indicating a relatively smaller role of RAD54 DNA translocation in this process. Thus, the use of SN enabled us to identify important differences in the effect of the RAD54 ATPase and DNA translocation on two major activities of RAD54, BM of Holliday junctions and stimulation of DNA pairing.


The process of aquaculture is an activity that potentially generates organic waste primarily derived from residual feed and the results of excretion (feces). Heterotrophic bacteria have the ability to produce extracellular enzymes (protease enzymes, amylases, and cellulases) that are necessary for the bioremediation of organic waste. The purpose of this study was to investigate the identifiable extracellular enzyme bacteria from extensive pond sediments in Tanggulrejo Village, Gresik. Twenty bacterial isolates were found from pond sediments that had the ability to produce extracellular enzymes and proteolytic, amylolytic and cellulolytic bacteria. The four isolates were identified as genera Bacillus thuringiensis, Bacillus lentus, Bacillus sphaericus and Corynbacterium pilosum. Bacillus thuringiensis bacteria have a hydrolysis zone of protein of 11 mm, a hydrolysis zone of amylum of 10 mm, and a hydrolysis zone of cellulose of 8 mm. Bacillus lentus bacteria have a hydrolysis zone of protein of 14 mm, a hydrolysis zone of amylum of 12 mm and a hydrolysis zone of cellulose of 7 mm.Bacillus sphaericus bacteria have a hydrolysis zone of protein 14 mm, a hydrolysis zone of amylum of 11 mm and a hydrolysis zone of cellulose of 6 mm. Corynebacterium pilosum bacteria have a hydrolysis zone of protein of 10 mm, a hydrolysis zone ofamylum of 14 mm and a hydrolysis zone of cellulose of 16 mm.


Aims. We investigate the formation of neutral and singly ionized scandium lines in the solar photospheres. The research is aimed at derive solar log gf e� (Sc) values for scandium lines, which will later be used in differential abundance analyses of metal-poor stars. Methods. Extensive statistical equilibrium calculations were carried out for a model atom, which comprises 92 terms for Sc i and 79 for Sc ii. Photoionization cross-sections are assumed to be hydrogenic. Synthetic line profiles calculated from the level populations according to the NLTE departure coefficients were compared with the observed solar spectral atlas. Hyperfine structure (HFS) broadening is taken into account. Results. The statistical equilibrium of scandium is dominated by a strong underpopulation of Sc i caused by missing strong lines. It is nearly unaffected by the variation in interaction parameters and only marginally sensitive to the choice of the solar atmospheric model. Abundance determinations using the ODF model lead to a solar Sc abundance of between log e� = 3.07 and 3.13, depending on the choice of f values. The long known difference between photospheric and meteoritic scandium abundances is confirmed for the experimental f -values.


It is shown that the stem effect is not a constant fraction but a variable, changing with the voltage between the electrodes. The linearity of the stem effect has been checked also as a function of exposed stem length by measurement of the contributions of parts of the pure stem.


Abstract This study presents an investigation of teachers' beliefs about working with English learners, as constructed in online class discussions. Using conversation and discourse analysis from a discursive psychology (DP) perspective, analysis focuses on the discursive production of beliefs and the social actions achieved by this production in interaction. By orienting to teachers' beliefs as interactionally emergent phenomena, findings highlight the ways that teachers account for their belief claims and the ways that teachers' statements of belief work to perform certain social functions within the forum itself, including affiliation and disagreement. Implications for teacher education and for the potential of DP to contribute to research on teachers' beliefs are discussed.


The paper presents a novel photo-voltaic PV powered battery charging station. The flexible scheme developed by the first Author is controlled by a FACTS-based Green Plug-Filter Compensator GPFC to ensure efficient utilization and DC-common bus stabilization. The multi-regulator multi-loop error driven modified PID-controller ensures efficient fast charging and full DC bus stabilization under load excursions and fault condition.


FIELD: agriculture. SUBSTANCE: method of pre-sowing treatment of hybrid potato seeds comprises treatment of potato with 0.1% solution of salicylic acid in which apple wastes are added in amount of 10-15% of the total solution volume. Then the potatoes are kept for 8-10 hours, followed by exposure of the seeds for 1-1.5 hours. EFFECT: method enables to reduce the cost of pre-sowing treatment of hybrid seeds, to increase their germination. 1 tbl, 3 ex


Purpose. This is a randomized, multi-center, double-dummy, and active-controlled study to evaluate the efficacy and safety of balsalazide as compared to mesalamine for a treatment period of eight weeks in patients with acute exacerbation of ulcerative colitis. Methods. Subjects with acute exacerbation of ulcerative colitis and had symptomatic grade 2~4 ulcerative colitis after being checked by sigmoidoscopic examination were recruited for the study. Subjects were randomized to received balsalazide (750 mg/cap, 3# tid) and mesalamine (400 mg/tab, 2# tid). Fifty-two subjects were enrolled into the study, forty of them completed eight weeks treatment. Efficacy and safety were evaluated after eight weeks treatment. Results. Complete remission occurred in 8 of 17 (47.1%) patients in the balsalazide group and 10 of 23 (43.5%) patients in the mesalamine group. Sigmoidoscopic improvement is more significant in the balsalazide group (82.35%) than mesalamine group (47.83%). Adverse event was experienced in 17 of 24 patients (70.8%) in the balsalazide group and 18 of 28 patients (64.3%) in the mesalamine group. There were no clinically significant changes in routine laboratory assessments and vital signs in either treatment groups. Conclusion. This study confirmed that 8 weeks of treatment with 6.75g daily of balsalazide is safe, well tolerated, and effective for acute ulcerative colitis. Balsalazide is therefore proven to be an effective treatment in the management of ulcerative colitis.


Previous fluoroscopic analyses of Total Hip Arthroplasty (THA) determined that the femoral head slides within the acetabular cup, leading to separation of certain aspects of the articular geometries. Although separation has been well documented, it has not been correlated to clinical complications or a more indepth understanding of the cause and effect. Surgical technique is one of the important clinical factors when considering THA procedures, and it is hypothesized, that it could affect the magnitude and occurrence of femoral head separation (sliding) in THAs. Hence, the objective of this study was to determine and compare in-vivo THA kinematics for subjects implanted with a THA using two different surgical approaches. Thirty seven subjects, each implanted with one of two types of THA were analysed under in vivo, weight-bearing conditions using video fluoroscopy while performing a sit-to-stand activity. Ten subjects were implanted by Surgeon 1 using a long incision postero-lateral approach (G1); while a further 10 subjects were implanted by the same surgeon using a short incision posterolateral approach (G2). The remaining 17 subjects were implanted using the anterolateral approach; 10 by Surgeon 2 (G3) and seven by Surgeon 3 (G4). All patients with excellent clinical results, without pain or functional deficits were invited to participate in the study (HHS > 90). 3D kinematics of the hip joint was determined, with the help of a previously published 2D-to-3D registration technique. From a completely seated position to the standing position, four frames of the fluoroscopy video were analysed. Subjects in all groups experienced some degree of femoral head separation at all increments of the sit-to-stand activity that were analysed. The magnitude and frequency of separation greater than 1.0mm varied between each surgeon group, between incision types, between incision lengths and between the two types of THA that were analysed. The average maximum separation was 1.3, 1.1, 1.3 and 1.4mm for G1, G2, G3 and G4 respectively. Though there was no difference in the average maximum separation values for the 4 groups, the maimum separation varied significantly. While the maximum separation in G2 was 1.8mm, the maximum separation in G4 was 3.0mm. G1 and G3 had maximum separation values of 2.3mm and 2.4mm respectively. This study suggests that there may be a correlation between incision lengths and surgical approach with femoral head separation in THAs. The maximum separation that was seen among all groups was a subject with a traditional long incision, while the short incision group had less incidence of separation. Results from this study may give researchers and implant developers a better understanding of kinematics around the hip joint and how they vary with respect to different surgical techniques. Further analysis is being conducted on the subjects before definitive conclusions can be made.


In this paper, for the first time Python was used to model the long period fibre grating devices and simulate the light propagating in the waveguide structures in order to design and optimize LPFG devices for sensing applications. It begin with resolving the effective refractive index of the LP01 core mode and different cladding modes, followed by calculating the mode electric and magnetic fields to determine the strength of coupling for core mode as well as between core mode and different cladding modes. After then, the transmission power spectrum within typical telecommunication wavelengths range was plotted. The spectrums and the wavelength shift under different surrounding refractive index was then plotted to analyze the SRI sensitivity of LPFG devices. Eventually, the results of Python and MATLAB will be compared for verification.


The Genia event task, a bio-molecular event extraction task, is arranged as one of the main tasks of BioNLP Shared Task 2011. As its second time to be arranged for community-wide focused efforts, it aimed to measure the advance of the community since 2009, and to evaluate generalization of the technology to full text papers. After a 3-month system development period, 15 teams submitted their performance results on test cases. The results show the community has made a significant advancement in terms of both performance improvement and generalization.


The hepatitis B virus (HBV), discovered in 1966, infects more than 350 million people worldwide.1 Hepatitis B is a leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma, accounting for 1 million deaths annually. Knowledge of the intricacies of viral infection and of the molecular biology of this fascinating virus has led to the successful development of a vaccine and to treatment sometimes capable of eradicating chronic infection. This review addresses many aspects of HBV infection, including the role of the immune system in determining the outcome of clinical infection, recent developments in molecular studies of the virus, and new . . .


Distributed real-time systems are difficult to construct such that the system behaves predictably. In addition, many of these systems must operate in complex and uncertain environments. We discuss several hardware-based ideas for moving distributed real-time systems towards predictability: adjustable flow control filters, reflective memories, and scheduling coprocessors. We believe that these hardware based solutions should be exploited for enhancing predictability and rebustness, especially as hardware becomes cheaper. The idea of adjustable flow control filters is a new idea being proposed here. Although reflective memories are available off the shelf, here we discuss their value in distributed scheduling and fault tolerance. Scheduling coprocessors can reduce the cost of online scheduling so that dynamic rescheduling and early warning of impending missed deadlines can occur


28 Mycorrhizal fungi form ubiquitous symbiotic associations with almost all land plants and are of key 29 interest to evolutionary biologists and ecologists because this ancient symbiosis was essential for the 30 colonization of land by plants – a major turning point in the evolutionary history of the earth – and the 31 subsequent development and functioning of the terrestrial ecosystems. Within the orchid family 32 (Orchidaceae), plants establish unique interactions with specific orchid mycorrhizal fungi. These fungal 33 symbionts are essential for the development of orchids as they provide carbon and soil nutrients to 34 germinating orchid seeds and the nutritional supply continues for adult orchids to different degrees. 35 Fueled by the development of DNA sequencing techniques, the diversity of mycorrhizal and other root- 36 associated fungi in orchid roots has been extensively reported in evolutionary and ecophysiological 37 studies. However, the full taxonomic range of orchid-associated fungi remains to be investigated in a 38 broad phylogenetic framework, hampering a further understanding of the evolution and ecological 39 adaptation of orchid mycorrhizal interactions. In this study, we used the most complete DNA dataset to 40 date to map the phylogenetic distribution and ecological lifestyles of root-associated fungi in 41 Orchidaceae by phylogenetic reconstructions at the fungal order level. We found that a broad 42 taxonomic range of fungi (clustered into 1898 operational taxonomic units) resided in orchid roots, 43 belonging to at least 150 families in 28 orders in Basidiomycota and Ascomycota . These fungi were 44 assigned to diverse ecological lifestyles including typical orchid mycorrhizal fungi ('rhizoctonia'), 45 ectomycorrhizal fungi, wood-or litter-decaying saprotrophic fungi, and other 46 endophytes/pathogens/saprotrophs. This overview reveals that among the four different mycorrhizal 47 types, the orchid mycorrhizal symbiosis probably involves the highest diversity of fungal taxa. We 48 hope that our newly reconstructed phylogenetic framework of orchid-associated fungi and the 49 assessment of their potential mycorrhizal status will benefit future ecological and evolutionary studies 50 on orchid-fungal interactions.


The utility model discloses an automobile ignition key hole illumination structure. The structure comprises a circular fluorescent plate, a circular through hole is arranged at the center of the fluorescent plate, the diameter of the circular through hole is greater than the length of an automobile ignition key hole, the luminous surface of the fluorescent plate is outwards arranged on the outer end face of the automobile ignition key hole, and the circular through hole is aligned with the automobile ignition key hole. The automobile ignition key hole illumination structure has the advantages of simple structure and low cost, has no any additional circuits, has certain significance for reducing the production cost, can realize no operation under an intense light condition, can automatically emit light for illumination under a weak light condition, and has high cost performance compared with the prior art.


The vocational colleges in west regions should pay attention to courses construction.For ensuring cultivation high quality workers,vocational colleges should construct curriculum system,teaching material system and teaching controlling system which correspond to the talent cultivation mode.


The magnetic fields in the corona is determined using multiple type II radio bursts observed on 20 January 2004 with the Culgoora solar radio spectrograph. Using the relation between the relative bandwidth of the band-split and the density in the upstream and the downstream of the shock the Alfven Mach number is estimated. From the observed drift rates of the multiple type II bursts the Alfven speed and the magnetic field is estimated. The relative bandwidths for the first and second type II bursts respectively are 0.28 and 0.20. The Alfven Mach numbers for the first and second bursts respectively are 1.64 and 1.44. The mean frequency of the first type II burst is 73 MHz and the same for the second burst is 49 MHz. The derived magnetic field varies from 1.30 to 2.24 Gauss for the first burst and 1.32 to 2.46 Gauss for the second burst for Newkirk's density with density enhancement factors 1 to 5. The associated activities show a single flare and a Coronal Mass Ejection (CME). The results are discussed in the frame work of the single flare/CME.


The historical associations between bacteria and peptic ulcer disease Taxonomy of Helicobacter pylori Isolation and characteristics Helicobacter pylori The ultrastructure of Helicobacter pylori Ultrastructure of Helicobacter pylori in vivo Detection of Helicobacter pylori by histology Detection of Helicobacter pylori by the biopsy urease test The serology of Helicobacter pylori infections Detection of helicobacter pylori by the 14C-urea breath test Detection of Helicobacter pylori by the 13C-urea breath test Epidemiology of Helicobacter pylori infection Helicobacter pylori and chronic gastritis Helicobacter pylori, duodenitis and duodenal ulceration Helicobacter pylori, gastric ulceration and the post-operative stomach Helicobacter pylori and gastric cancer Helicobacter pylori and non-ulcer dyspepsia Helicobacter pylori in paediatric populations Helicobacter pylori and spontaneous hypochlorhydria Helicobacter pylori colonisation and alterations in gastric physiology Helicobacter pylori: human ingestion studies Possible pathogenetic mechanisms in Helicobacter pylori infection Bacteriological and pharmacological basis for the treatment of Helicobacter pylori infection Helicobacter pylori: treatment of gastritis Helicobacter pylori and ulcer treatment Helicobacter pylori and related organisms in animals Perspectives on the pathogenesis of Helicobacter pylori infections Is Helicobacter pylori a significant pathogen? Index


Two isolates of mucous bacteria, mc75 and pc78, were isolated from fungal culture plate as culture contaminants with an interesting swarming motility. Both isolates were identified as Pseudomonas fluorescens based on microscopy, biochemical analysis, Biolog test and DNA sequence analysis of the 16S rRNA gene. Both strains have the exactly the same 16S rRNA gene sequences, and yet their biological control activity were not identical each other. In vitro analysis of antagonistic activity of two isolates against several plant pathogenic fungi indicated that both produced diffusible and volatile antifungal compounds of unknown identities. Treatment of the bacterial culture of P. fluorescens pc78 and its culture filtrate exhibited a strong biological control activity against rice sheath blight in vivo among six plant diseases tested. More effective disease control activity was obtained from treatment of bacterial culture than that of culture filtrate. Therefore, in addition to antifungal compound and siderophore production, other traits such as biofilm formation and swarming motility on plant surface may contribute to the biological control activity of P.fluorescens pc78 and mc75.


The paper studies the basic characteristic of desert,Its conclusion is that when the wind velocity is ≥8 m/s(namely 5 class),the granules of sand will be blown and conveyed and then even becomes sand flow.It causes the soil erosion and land desert.The paper uses the example of hongcheng model unfixed district in Tailai county then puts forward the ecological rehabilitation countermeasures.


The invention discloses a gateway selecting method and a gateway selector. The method comprises the following steps: the gateway selector acquires strategy information of a user from a user contract or a user message for building network connection; the gateway selector performs gateway query according to the strategy information to obtain a gateway matched with the strategy information as the selected gateway. In the invention, the gateway can be selected according to multiple strategies, so as to meet different practical deployment requirements.


SUMMARY

The paper is a contribution to the study of the instabilities associated with traveltime data inversion in tomographic seismology. It has been found that there are circumstances in which instabilities may be mitigated by reducing in a proper way the number of seismic paths taken into account for the inversion. In order to choose such a set of rays, it has been found useful to apply a pre-selection algorithm which, starting from the set of all available seismic paths, gives a new configuration of rays by minimizing the configuration score. the score is a scalar whose value depends upon some geometrical characteristics of the ray pattern, such as the local ray density and the azimuthal distribution. the method is presently applied to 2-D models where the region crossed by the seismic rays is partitioned into rectangular cells, which is a feature not unusual in tomographic investigations. Numerical experiments of inversion are carried out in order to show the 'goodness' of the new algorithm. Comparison with solutions computed without pre-selecting the seismic rays shows the advantage of applying our algorithm for the considered cases. As a measure of the performance, the magnitude as well as the space distribution of the discrepancy between the computed field and the true solution is used in addition to a number of other suitable indicators.


PROBLEM TO BE SOLVED: To determine the pressure difference between first and second conduits easily providing a solenoid valve to be coupled with a conduit and determining the pressure difference based on a predetermined pressure gradient, a signal characterizing the duration of control of a first solenoid valve, and the pressure difference before control. SOLUTION: An inlet valve 100 is coupled through a first port and a first conduit 105 with a main brake cylinder 110 and coupled through a second port and a second conduit 115 with a wheel brake 120. The conduit 105 is normally applied with a pressure PV while the conduit 115 is applied with a pressure PH for determining the brake power of wheel. A connection passage extends from the conduit 115 to the first port of an outlet valve 160 having a second port coupled with a return carrying pump 170. The valves 100, 160 are so-called 2/2 solenoid valves. Pressure difference between the pressures PV and PH is determined based on a predetermined pressure gradient, a signal characterizing the duration of control of a first solenoid valve, and the pressure difference before control. COPYRIGHT: (C)1996,JPO


There is a trend in Taiwan to offer computer programming as an elective course for all high school students. Although students seem to be quite enthusiastic about learning to program at the beginning of the course, students' enthusiasm quickly dissipated when the practice program becomes too complex for them to bear. To help students learn better, we have implemented a cloud-based cloze programming practicing system. The system allows teacher to upload a program and then block out part of the program that is intended for students to practice. The blocked out code can be as simple as a variable declaration or as complex as a complete function. In the extreme case, the entire program could be blocked out, meaning students have to write the complete program. Therefore, teachers can have students practice a particular aspect of programming by supplying multiple programs and block out the same part of the program for students to fill-in. Students can submit their completed program online and the system will automatically compile and execute the program with pre-assigned input data. Any compiler time error, execution time error, or incorrect output would be reported back to the students for debugging. The on-going teaching experiment has the teachers teach programming as usual, but prepare cloze programming tasks for students to practice. Many such cloze programming exercises of various difficulties have also been developed.


A new post-chemiluminescence(PCL) phenomenon was observed when arbidol hydrochloride solution was injected into the solution after the finish of CL reaction of alkaline luminol and potassium ferricyanide.A possible reaction mechanism was proposed based on the studies of the CL kinetic characteristics,the CL spectra,and other experiments.Using the PCL reaction,a new method for the determination of arbidol hydrochloride was established.The linear response range of this method was from 6.0×10-9 to 1.0×10-7 g/mL with a linear correlation coefficient of 0.9991.The relative standard deviation for 4.0×10-8 g/mL solution was 1.3%(n=11).This method has been successfully applied to the determination of arbidol hydrochloride in arbidol hydrochloride capsules and urine samples with satisfactory results.


Microwave (MW) heating was successfully applied to synthesize SAPO-34 zeolite membranes from a colloidal solution containing tetraethylammonium hydroxide, silica source, phosphorus source and aluminium source. The presence of SAPO-34 phase was detected using X-ray diffraction (XRD) while the morphology and thickness of the SAPO-34 membranes were investigated by scanning electron microscope (SEM). The synthesized SAPO-34 membrane was studied for its single gas permeance of carbon dioxide (CO2) and nitrogen (N2). Gas separation of CO2/N2 binary gas mixture was performed on the SAPO-34 membrane over different temperature and feed pressure. Thin SAPO-34 membrane was formed at 473 K for synthesis time of 2 hours using microwave heating. The membrane exhibited the presence of SAPO-34 zeolite crystals with uniform size (< 1 m). MW heating is a highly potential method for rapid synthesis of zeolite membrane. Its instantaneous and volumetric heating resulted in formation of zeolite membrane consisting of zeolite crystals with narrower size distribution.


Event cameras record sparse illumination changes with high temporal resolution and high dynamic range. Thanks to their sparse recording and low consumption, they are increasingly used in applications such as AR/VR and autonomous driving. Current top-performing methods often ignore specific event-data properties, leading to the development of generic but computationally expensive algorithms, while event-aware methods do not perform as well. We propose <italic>Event Transformer<inline-formula><tex-math notation="LaTeX">$^+$</tex-math><alternatives><mml:math><mml:msup><mml:mrow/><mml:mo>+</mml:mo></mml:msup></mml:math><inline-graphic xlink:href="sabater-ieq2-3311336.gif"/></alternatives></inline-formula></italic>, that improves our seminal work <italic>EvT</italic> with a refined patch-based event representation and a more robust backbone to achieve more accurate results, while still benefiting from event-data sparsity to increase its efficiency. Additionally, we show how our system can work with different data modalities and propose specific output heads, for event-stream classification (i.e. action recognition) and per-pixel predictions (dense depth estimation). Evaluation results show better performance to the state-of-the-art while requiring minimal computation resources, both on GPU and CPU.


In most of the organizations, Employee Attrition has been one of the greatest concerns in today's world. The reason behind this can be due to personal or company related issues such as long- distance travelling, no work life balance, less salary hike, no job satisfaction etc. According to a study done by Businessdictonary, employee attrition results from resigning from their post, retirement, illness, or demise. Considering these issues, the project aims to find the employees who are most likely to attrite from the organization using pre-processing techniques such as exploratory data Analysis (EDA), feature selection techniques and utilizing various machine learning techniques such as Logistic Regression, Support Vector Machine (SVM) and Random Forest. According to which several programs can be incorporated by the organizations to minimize the attrition rate and also help in building and maintaining a robust relationship between the employees and the organization.


Mathematical modeling algorithm for the numerical analysis of the dynamics and evaporation of the water droplet which is injected into a gas-vapor flow is offered. The algorithm was tested with the help of the problem solution about a viscous fluid flow in a plane channel of constant cross section. It was shown that the proposed mathematical model and implementation algorithm are adequate to the physics of the investigated process. It was shown that the proposed mathematical model and implementation algorithm are adequate to the physics of the investigated process. Results of numerical study of the flow structure of the gas-vapor mixture in the channel with injection of water droplet under varying the initial droplet parameters are given.


HAZOP study is a systematic technique to identify the hazards present in a plant, to analyse the consequences and to recommend suitable modifications to prevent occurrence of hazardous and inefficient conditions or operating problems.


This essay baseel on several Psychological elements in performing the music,sheds some loght on the comprehensive psychology and the importance of high accomplishment as a performer.


In article examined the problems of the quality of training of future specialists. Today, teachers use innovative educational technologies. Educational technologies are associated with improving the efficiency of training and education, they are aimed at the end result of the educational process.


Ranabir Majumder a , Pratap Parida b , Samrat Paul a , Piyali Basak a * a School of Bioscience and Engineering, Jadavpur University, Kolkata, India b School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, India *Correspondence: Dr. Piyali Basak, Director, School of Bioscience and Engineering, Jadavpur University, Kolkata, India. Email id firstname.lastname@example.com, Mobile no. : +91-99033-03592 Abstract: Aloe vera leaf contains some bioactive compounds that have a strong binding affinity toward estrogen receptor as compared to standard drug tamoxifen. In this study, we have found that the IC50 of Aloe vera leaf extract against breast cancer cell line MCF-7 is 23 μg/mL which is much lower than the IC50 (332 μg/mL) of Aloe vera leaf extract against noncancerous cell line NIH-3T3. We have also calculated the total concentration of phenolic acid (385.662 μg/mL), flavonoids (160.402 μg/mL) and alkaloids (276.754 μg/mL) in Aloe vera leaf extract. The free radical scavenging activity of Aloe vera leaf extract is 67 % to 84% (at 50 to 300 μg/ml). Our virtual molecular docking study suggests that bioactive compounds like Aloe-emodin (-8.8 Kcal/mol), 7-hydroxy-2,5 dimethylchromone (-7.5 Kcal/mol), Betasitosterol (-7.3 Kcal/mol) etc. have a greater binding affinity toward estrogen alpha receptor as compared to standard drug Tamoxifen (-6.4 Kcal/mol).


Abstract According to Hobfoll's conservation of resources theory (1989), psychological resources such as resilience and self-efficacy could mediate the effects of unemployment on well-being. The objective of this study is to analyse the mediating role of self-efficacy and resilience on the relationship between the amount of time unemployed and psychological distress. A sample of unemployed persons from the Region of Murcia was used (N = 280). With a transversal design and using the macro PROCESS for SPSS (2013), a multiple mediation model is proposed which analyses the mediating role of psychological resources in relation to the amount of time unemployed and self-perceived health. The explained variance of this model is 23.79%. The results show that only self-efficacy partially mediates in the relationship between the two variables (β = .18, SD = 0.06, p < .01). The main contribution of this article is showing that personal psychological resources are an effective tool to cope with life stressors, such as, in this case, unemployment.


The Late Cretaceous(.)-Eocene Sheep Pass Formation of east-central Nevada is a thick (1500-m) sequence of nonmarine conglomerate, sandstone, mud rock, and limestone. Detailed stratigraphic analyses of the basal conglomerate (50 to 450 m thick) in the Egan, Pancake, and Fish Creek ranges was performed. The presence of large (up to 400 m) Paleozoic limestone slide blocks and paucity of sandstone lithofacies within conglomeratic sequences in the Egan Range suggest deposition on the proximal to medial portion of streamflow-dominated alluvial fans. Clast imbrication measurements document east-northeast to west-southwest paleoflow directions throughout the region. In the Egan and Pancake Ranges, gravel is comprised predominantly of Pennsylvanian-Permian carbonate and Mississippian quartzarenite (Scotty Wash). Gravels in the Fish Creek Range consist of paleozoic dolomite and Ordovician quartzarenite (Eureka) at the base of the Sheep Pass, and Paleozoic limestone and dolomite, Mississippian quartzarenite, and Ordovician quartzarenite near the top. Preliminary interpretations of our data indicate that Late Cretaceous-early Tertiary sedimentation in the hinterland of the Sevier orogenic belt occurred in a series of small basins characterized by general westward sediment dispersal patterns. Further interpretations of hinterland basin development and structural setting of basin-bounding uplifts await further work on Cretaceous-Eocene strata now in progress.


The nucleation behavior of poly(e-caprolactone) (PCL) on friction-deposited poly(tetrafluoroethylene) (PTFE) was investigated by means of atomic force microscopy (AFM). This technique allows for imaging of the nucleation and crystallization processes in real time. An estimation of the PCL crystal orientation on the PTFE substrate is made by evaluating the growth rates and the growth geometry of the lamellar crystals formed on PTFE. On the basis of the data collected, it is proposed that PCL crystallizes on PTFE predominantly via a (100)PCL contact plane (∼80%). The crystals adopt an orientation that minimizes the lattice mismatch at the interface between the nucleating PTFE and PCL. A (010)PCL∥(100)PTFE contact plane was simultaneously observed at a lower occurrence of approximately 20%. Visualization of the PTFE fibrillar morphology at higher resolution during isothermal crystallization revealed the appearance of a third PCL crystal orientation which developed later in time. The corresponding crystals we...


/ :,I1.,_..~'.."I.':,..!:hl \'..! ;l\ """'. I IIII-II~ Within the field oi aging, the conceptualization and measurement of iunctioning has been dominated by the disability model. In this paper, one limitation of that model is described by calling attention to a distinClion oetween three "tenses" of functioning. Inadequate attention has heen paid to the distinction between the capacity 10 function in Ihe abstract (hypothetical (ense) and actual periormance in daily life (enacted tense). Failure to attend to this distinction has obscured considerable discordance between what people say they arc able to do in standard functional disabilily .1ssessmenls, and what they actually do al home. To illustrate this point, dala from the MacArthur Studies of Successful Aging comparing the hypothetical to (he en.lcted tenses are presented. These data show a consistent pattern of discordance between these two tenses.


The utility model discloses a pore electro-discharge process machine for the double uses of drilling holes and attacking teeth, composed by installing an electro-discharge and tooth-attacking mechanism on a conventional pore electro-discharge process machine. The electro-discharge and tooth-attacking mechanism utilizes a rotary shaft (R shaft) and process shaft (Z shaft) to coordinatingly serve the feeding of an electromotor, a screw thread electrode arranged on the rotary shaft, a guide eye module provided with internal screws, a discharging power supply and process fluid form the functions of discharging and attacking teeth, the process fluid is disposed on the hollow portion of the screw thread electrode, and the process fluid is pressurized and passes through the middle portion of the electrode and a work piece to discharge residues which can also be discharged by a vacuum suction via a vacuum suction device. The utility model can promotes the functions of the pore electro-discharge process machine of discharging and drilling holes to the functions of both discharging and attacking teeth, thereby one machine has multiple purposes. Consequently, the production efficiency is improved and the cost is reduced.


Abstract 2342 Background: NOX-H94, the first-in-class hepcidin inhibitor in development for treatment of anemia of chronic disease (ACD), is a PEGylated anti-hepcidin L-RNA oligonucleotide. ACD is caused by iron sequestration in the reticulo-endothelial macrophages with subsequent iron restricted erythropoiesis due to high hepcidin production and subsequent ferroportin degradation. The treatment of ACD is challenging: a significant number of ACD patients do not respond to erythropoiesis stimulating agents (ESAs), while repeated intravenous iron administrations bear a risk of iron overload. Targeting hepcidin may provide more efficacious and well tolerated treatment alternatives. Methods: This First-in-Human study investigated the safety and tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of escalating single and repeated doses of intravenous (i.v.) NOX-H94 in healthy men and women. The study protocol (ClinicalTrials.gov identifier NCT01372137) was approved by an independent ethics committee and conducted in accordance with the Declaration of Helsinki. Five successive cohorts of 8 healthy subjects, at least 3 men and women, were randomly assigned to i.v. doses of 0.3, 0.6, 1.2, 2.4, and 4.8 mg/kg of NOX-H94 (n=6) or placebo (n=2). Similarly, 2 cohorts of 8 male subjects randomly received 5 doses of either 0.6 or 1.2 mg/kg NOX-H94 or placebo every other day (q2d). Safety parameters, iron parameters, total hepcidin-25 (sum of free circulating hepcidin-25 and hepcidin-25 bound to NOX-H94), and PK were assessed during treatment and follow-up periods of ≥3 weeks. Data are given as means±SD. Results: One man, assigned to 5 i.v. doses of 0.6 mg/kg, withdrew consent after 4 administrations; all other 55 subjects completed the study as scheduled. Safety: Treatment with NOX-H94 was generally safe and well tolerated. No serious adverse event occurred; headache and fatigue were the only treatment related events that occurred more than once. Mild and transient increases in transaminases ( PK: After escalating single i.v. administrations of 0.3 to 4.8 mg/kg of NOX-H94, peak plasma concentrations of NOX-H94 (C max ) and systemic exposure (AUC) increased dose-proportionally. The elimination was bi-phasic with a terminal plasma half-life (t ½ ) in the range of 17 to 26 h. The systemic clearance (CL) was low (Table 1). After repeated q2d i.v. administrations, no appreciable plasma accumulation was found based on C max and AUC. No obvious gender-difference was observed. PD: The plasma concentration of total hepcidin-25 increased dose-dependently upon NOX-H94 treatment, without ever exceeding the plasma concentration of NOX-H94. The PD effects were assessed by analysis of the area under the data time curve above baseline (AUD) of various iron parameters. Single and repeated doses of NOX-H94 up to 0.6 mg/kg had no effect on serum iron, serum ferritin, and transferrin saturation (TSAT) in the healthy subjects studied. At doses ≥1.2 mg/kg NOX-H94, serum iron, serum ferritin, and TSAT increased dose dependently. Conclusions: Treatment with NOX-H94 was generally safe and well tolerated over all dose levels and schedules studied; for subsequent phase II studies in patients, twice weekly i.v. doses of 1.2 mg/kg are recommended. PK analyses showed a dose-linear systemic exposure. In these healthy subjects, only mild dose-dependent increases in iron parameters were observed which likely underestimate the effects that may be obtained in patients with iron-restricted anemia. Disclosures: Riecke: NOXXON Pharma AG: Employment. Zollner: NOXXON Pharma AG: Employment. Vauleon: NOXXON Pharma AG: Employment. Swinkels: NOXXON Pharma AG: Research Funding. Dummler: NOXXON Pharma AG: Employment. Summo: NOXXON Pharma AG: Employment. Schwoebel: NOXXON Pharma AG: Employment. Fliegert: NOXXON Pharma AG: Employment.


The testing and characterization of an IC is a major step in an IC design process. Building a test setup and performing various measurements are challenging and require extensive amount of time and resources. Comparing the measurement and simulation results is a crucial step to verify the real performance of an IC. This thesis describes implementing and performing IC measurements to characterize a 5G beam steering receiver IC. The IC has been manufactured using 28-nm CMOS technology, and it has four direct-conversion. The receiver has different blocks to experiment beam steering, blocker detection and pilot signal calibration techniques. Measurement hardware around the IC has been designed and manufactured based on a PCB with multiple high speed signal lines. Circuit and electromagnetic simulators have been extensively utilized in various tasks, such as matching and outlining microstrip lines. The PCB has been designed using Altium Designer environment and Rogers RO4350B as a substrate. Testing the performance and characterizing the IC include various type of measurements and equipment. To ease the measurements, measurement automation has been constructed using Matlab environment and Object-Oriented Programming. Matlab is used to control measurement equipment and the IC. Various measurement sequences have been written to automate numerous measurements, including gain, ICP, IIP3, Noise figure, ADC and FFT measurements. Prior to measurements, the IC has been wirebonded on the manufactured PCB, and the needed SMD components have been soldered by hand. After hardware fabrication, circuit blocks inside the IC have been tested and characterized. This includes blocks, such as DC, SPI, RF, ADC and FFT. Eventually, the measurement results have been compared to simulation results. Furthermore, the radiation pattern of the receiver has been measured in an anechoic antenna chamber. Concurrently, preliminary beam steering tests have been conducted. All the planned measurements have been carried out. The measurements yielded a little lower performance than the simulated performance. Nevertheless, the measured performance of the IC is adequate to study beam steering, blocker detection and pilot signal calibration techniques.


3 Acute occlusion of the cerebral artery leads to time‐dependent ischemic brain tissue damage. If the artery is not opened urgently, the ischemic process worsens, leading to tissue death and consecutive cerebral infarction. The most important determinants of the quality of life as well as life expectancy of stroke survivors are time of recanalization, ischemic area, and collateral circulation patency. At the moment, the only approved treatment for acute ischemic stroke is intravenous (IV) recombinant tissue plasminogen activator (tPA) administered within the first 3 hours after symptom onset. When given IV, tPA initiate very fast intra‐arterial thrombus dissolution. This early but very often only partial recanalization can lead to ischemic tissue rescue and subsequent clinical recovery. Unfortunately, less than 5% of patients with ischemic stroke receive IV tPA and only 30 to 40% of treated patients achieve early recanalization, that is complete and sustained in less than 20% of patients.[1]


CoS2 with a three-dimensional porous structure has attracted great interest because of its excellent electrical, magnetic, and optical properties. However, the nonlinear optical properties of CoS2 ...


A method of controlling a call and an electronic device for performing the method are provided. The electronic device includes a communication unit for establishing a communication link with respect to at least one external electronic device, a sensor module configured to detect at least one piece of sensor data, and a controller configured to select at least one device for outputting a sound from at least one of the electronic device, and the external electronic device, the selection made on the basis of at least one of the at least one piece of sensor data detected through the sensor module, and situation information of the at least one external electronic device, in a state of being connected to the at least one external electronic device. In addition, other embodiments are also possible.