The invention relates to a rare earth attapulgite composite mineral fertilizer which takes macroelement phosphorus as a main material and agricultural rare earth and attapulgite ore microelements as auxiliary materials. The rare earth attapulgite composite mineral fertilizer is characterized by being prepared from the following components in percentage by weight through mixed slurrying, acidolysis and activation: 55.0%-60.0% of phosphate ores, 8.0%-10.0% of agricultural rare earth, 8.0%-10.0% of attapulgite ores and the balance of water. The rare earth attapulgite composite mineral fertilizer disclosed by the invention can be widely suitable for various crops, can greatly improve the condition of salt and alkali hardening of soil by being used for a long time, promote the root system development of the crops and reduce the phenomenon of no harvest of dead seedlings caused by the salt and alkali hardening of the soil, and can enhance the utilization ratio of the nutritive elements of the fertilizer, improve the quality of agricultural products and enhance the drought resistance and adversity resistance of the crops.


We study Raman scattering in the superconducting state of alkali-intercalated iron selenide materials AxFe2-ySe2 (A=K,Rb,Cs) in which Fermi surface has only electron pockets. Theory predicts that both s-wave and d-wave pairing channels are attractive in this material, and the gap can have either s-wave or d-wave symmetry, depending on the system parameters. ARPES data favor $s-$wave superconductivity. We present the theory of Raman scattering in AxFe2-ySe2 assuming that the ground state has s-wave symmetry but $d-$ wave is a close second. We argue that Raman profile in d-wave B2g channel displays two collective modes. One is a particle-hole exciton, another is a Bardasis-Schrieffer-type mode associated with superconducting fluctuations in d-wave channel. At a finite damping, the two modes merge into one broad peak. We present Raman data for AxFe2-ySe2 and compare them with theoretical Raman profile.


Riekels and Baker (1977) have reinterpreted the strain history of the Moine Thrust mylonite zone using fabrics measured by X-ray analysis in a quartzite mylonite (specimen 62, Christie 1963). In the introduction to their paper they state "Because quartz is prone to recrystallization, and most of the specimens with grains large enough to be measured optically have recrystallized, it is suspected that much of the deformation history that could have been recorded in the fabric has been erased." Approximately 30% of specimen 62 consists of small recrystallized grains. Hence the pole figures obtained by X-ray analysis contain a 30% contribution from the small newly recrystallized grains, and a 70 % contribution from the deformed host grains. Riekels and Baker acknowledge that Christie obtained a perfectly orthorhombic pattern when he optically measured only the deformed host grains. They realize that the difference in fabric they get for 0003 compared with Christie's 0001 fabric is due to the newly recrystallized grains. Yet they then interpret the monoclinic fabrics obtained by X-ray analysis, in terms of the deformation history the rock has suffered. It has been demonstrated that host and new grain fabrics for 0001 of quartz in mylonitic rocks differ considerably (Bell and Etheridge 1976). Host grains can have an orthorhombic fabric while the new grains from the same rock have an asymmetric fabric (compare G3c host and new grains, fig. 14, Bell and Etheridge 1976).


Both NO and adenosine produced from eNOS and cell surface CD73 in endothelial cells (EC), respectively, are potent vasodilator and anti‐inflammatory molecules. Adenosine increases eNOS expression and activity in EC. We examined if NO regulates cell surface expression of CD73 in EC under shear stress.


The S=1/2 kagome-lattice antiferromagnet is investigated using the numerical diagonalization of finite-size clusters. The analysis of the susceptibility at the zero magnetization indicates that the magnetic excitation of the system is gapless. It is consistent with our previous finite-scaling analysis of the spin gap. The application of the method for the triangular-lattice antiferromagnet confirms the validity of the analysis.


Polymer-nanometallic-particle composites have demonstrated technological potential owing to their unique optical and electrical properties. In this article, we report on composites prepared via physical vapor deposition of gold metal onto pliable polydimethylsiloxane (PDMS) polymer. Rapid Au diffusion and nanometallic-particle formation in a phase-separated surface layer of the PDMS creates unique tunable sub-surface-based composites. The rate of deposition and average Au thickness can be manipulated to tune the optical properties, which are studied by visible wavelength optical extinction spectrometry and surface-enhanced Raman scattering (SERS). DC conductivity measurements were made during Au deposition to study percolation conditions for the materials and depth profiling was performed by X-ray photoelectron spectrometry (XPS). This work presents the use of Au-PDMS nanocomposites in combination with a sample translation technique (STT) for the improved SERS qualitative and quantitative analysis. This translation approach considerably improves the reproducibility and the sensitivity of the technique by minimizing the thermal and photolytic effects inherent in SERS. The Au-PDMS nanocomposites exhibit an affinity for amine and nitro-based compounds that are biologically relevant and point toward the potential for being used as substrates for biologically based SERS experiments. Sample Raman spectra with the nanocomposite under STT-SERS conditions are included. Copyright © 2005 John Wiley & Sons, Ltd.


It is the main trend to explore the course according to working process when making curriculum reform of higher vocational education.And as a reform and practice,the essay studies on the course exploration of major of accounting under the mode of educating aiming at to job requirements,analyzes its importance and uses the course of Business Accounting of Supply and Sale as an example.The article introduces the developing idea and content of the course in detail,helping make a reference to other courses.


In this reply to commentaries by Tony Bass and Steven Kuchuck's discussions of "Finding Words: How the Process and Products of Psychoanalytic Writing Can Channel the Therapeutic Action of the Very Treatment It Sets Out to Describe," Altstein proposes that Loewald's reinvention of Freud's Oedipus conflict to include the act of parricide is active in the relationship between candidates at psychoanalytic institutes and the teachers and writers they revere. Psychoanalytic writing is offered as a potential—and useful—vehicle for the destruction of, honoring of, and joining with one's symbolic analytic parents.


This is an eminently readable book on a very important topic. It outlines a number of basic principles in providing for biodiversity within the context of urban and regional planning. The various case studies bring the subject to life, and in themselves give a positive vision to the maintenance of ecosystems. It focuses on the local-scale level of action that commonly falls within the province of the planning profession and this is both a valuable and practical focus. But on the broader scale, it is disappointing in that it devotes little attention to the role of protected areas, although its focus on offreserve conservation is indeed welcome. Regrettably, particularly for U.S. readers, it draws entirely upon experience in the United States. There is virtually no reference at all to broad-scale national or even state frameworks equivalent to the landcare and similar movements now found in many countries.


Objectives: Integrated fusion imaging modality Positron Emission Tomography Computed Tomography (PET/CT) using 18Fluorine-Fluoro Deoxy Glucose (18F-FDG) is commonly utilized in imaging oncology. We expand the role of this imaging modality in our study to demonstrate the appearance of active extra pulmonary tuberculosis (TB) lesions. Materials and methods: This study involved prospective evaluation of 8 patients using 18F-FDG PET/CT with confirmed diagnosis of extra pulmonary TB infection. Visually high intensity lesions in abnormal areas were studied where the mean and maximum standardized uptake value (SUVmean and SUVmax) were tabulated. The diagnosis of TB infection was confirmed by isolation of TB bacillus from these lesions or evidence of responding to anti TB treatment during post treatment evaluation using FDG PET/ CT at follow up. Results: The genders are equally affected. Majority of the group falls within young age below 50 years. Number of PET/CT studies demonstrating lesions either singly or multiple were equal in distribution. Nodal involvement is commonest in our study including mediastinum, paraaortic and inguinal groups. Other sites of infection include spine and bowel. The average SUVmax and SUVmean for all lesions were 7.7 and 5.2 respectively. Conclusion: Active TB lesions are FDG avid. Thus, FDG avid lesions should be interpreted with extra careful when FDG PET / CT is utilized in managing malignancy. Keywords: extra pulmonary tuberculosis, 18F-FDG PET/CT, SUVmax, false positive, malignancy


Correct quality matrix will be used to analyze the natural vibration characteristic with finite element method.This paper calculates the natural vibration frequencies of several wide-span bridges by using lumped quality matrix and consistent quality matrix.The result shows that it is different to analyze the bridges of three-D quality with lumped quality matrix and consistent quality matrix,and it is correct to analyze dynamic characteristic of large and complicated bridges by using consistent quality matrix.The obtained analysis results have great practical values for the analysis of natural vibration characteristic of related engineering structures.


The article is devoted to the problem of "Kiev text". The author analyses two works of M.A. Bulgakov, created and completed after visiting to his hometown of Kyiv in 1923, the sketch "Kiev-gorod" and the novel "The White Guard". To this end, at first, we examined the research history and research trends of "Kiev text" in Russian literature , and revealed the characteristics of "Kiev text".
We also saw that in "Kiev-gorod" and "The White Guard" the figure of Kyiv is depicted in 'history' as the image of falling Babylon, in the memory of the lyrical self and in Alexei's dream as the image of the heavenly Jerusalem.
As such, the myth of the confrontation between these two cities is the basis of Bulgakov's "Kiev text". Meanwhile, Bulgakov's 'city', which contains an eternal 'culture' that is not destroyed by any 'history', is unique in that it has myth and eternity.
In this way, this paper ultimately tried to find the literary meaning of the Bulgakov 's "Kiev text", and to read the most famous "Kiev text" of the 20th century, "The White Guard" and its documentary version, "Kiev-gorod", from a new perspective.


This article discusses the main issues of the formation and development of such a direction as environmental marketing. The main origins and reasons for the emergence of this approach were identified, and the main advantages of using it in various companies were established. It also presents a number of areas in which the company can carry out activities in the field of sustainable development. A number of companies are presented that are already actively introducing environmental marketing into their activities, and current trends in the development of environmental marketing in modern society are revealed.


We consider the problem of execution timing in optimal execution. Specifically, we formulate the optimal execution problem of an infinitesimal order as an optimal stopping problem. By using a novel neural network architecture, we develop two versions of data-driven approaches for this problem, one based on supervised learning, and the other based on reinforcement learning. Temporal difference learning can be applied and extends these two methods to many variants. Through numerical experiments on historical market data, we demonstrate significant cost reduction of these methods. Insights from numerical experiments reveals various tradeoffs in the use of temporal difference learning, including convergence rates, data efficiency, and a tradeoff between bias and variance.


This paper presents the organizational structure of the tea industry in Kenya. A background to the institutions within the industry is provided. The contribution of the respective organizations to the industry is presented. The paper also provides an overview of the successful management of a leading agricultural industry in Kenya, a country that is fourth largest producer of tea in the World. A brief background is given on the reform and necessity for establishment of the organizations.


A new species of the genus Hersilia Audouin, 1826, Hersilia aadi sp. Nov. is described from Andhra Pradesh, India with notes on the species known from India. The new species differs from its congeners based on having large palpal patella in males; and having two closely adjoining circular, small median genital openings and, long and curved copulatory duct in females.


The assistant garda commissioner has pleaded with youths not to get involved in the drugs trade at any level. We must provide initiatives to help, writes Cormac O'Keeffe.....


Abstract Máirtín Ó Cadhain's famously difficult Irish language novel Cré na Cille contains a cluster of Breton words that have not all been recognised as such. These words are a clue that the French-speaking airman, arguably the only character in the novel with a significant "arc", is in fact supposed to be a Breton. His immersion in Gaelic Ireland, his frustrated hope of fulfilment in philological studies and pan-Celticism and his ultimate lapse into patriotic Frenchness mirror the experiences of Breton nationalists of the 1940s – some of whom were helped by Ó Cadhain himself to take refuge in Ireland after the Second World War – and represent a subtle critique of Brittany's pan-Celticist hopes within the novel's larger multifaceted critique of Irish rural life.


Abstract Background The RTK AXL is implicated in epithelial-to-mesenchymal transition, negative regulation of anti-tumor immunity and resistance to multiple therapies including CPIs. Bemcentinib is a first-in-class, oral, highly selective and potent AXL inhibitor which has been demonstrated to enhance anti-PD1 therapy in the pre-clinical setting. Methods This PhII trial enrolled 48 advanced lung adenocarcinoma pts with progression on or after 1 prior line of PLT-based chemotherapy. Primary endpoint was ORR according to RECIST 1.1. Additional endpoints included efficacy according to biomarker expression, DCR, PFS, OS and safety. Tumor biopsies were analyzed for AXL by IHC, and PD-L1 expression (22C3 pharmDx). Additional biomarker analysis was also performed. Results In May 2019, Cohort A was fully recruited: median age 65 (range 39-82) yrs, 61% male, 76% smokers or ex-smokers. Pts had completed a median of 3 treatment cycles. 15 pts were ongoing. Out of 32 pts with available PD-L1, 17 (53%) had TPS 50%. Out of 33 patients with available AXL IHC, 19 (58%) expressed AXL on their tumors. Among pts who had at least 1 evaluable post-baseline scan: ORR was 10/38 (26%) overall, 6/16 (38%) in AXL positive pts (compared to 2/13 (15%) in AXL negative pts), and 7/30 (23%) in pts with TPS 0-49%. 12-mo OS was 54% overall (2 pts lost to follow up). mOS overall was 12.2 mos (95% CI 6.2 – NR). In pts with AXL positive tumors, mOS was 12.2 mos (2.0 – NR) and in AXL negative 12.7 mos (5.6 – NR). In PD-L1 negative pts, mOS was 12.4 mos (5.6-NR). Most common TRAEs (occurring in > 10% of pts) were transaminase increases (35%), asthenia/fatigue (30%), diarrhea (26%), nausea (13%), anemia (11%), and decreased appetite (11%). All cases of transaminase increase were reversible and resolved. 13 pts (28%) had TRAEs grade > 3, all of which were resolved or resolving at the time of writing. No treatment-related deaths were reported. Conclusions The combination of bemcentinib and pembro was well tolerated and showed promising efficacy in previously treated IO-naive NSCLC pts, particularly in those with AXL positive disease, including PD-L1 negative pts. mOS of > 12 mos is favorable compared with historical references in the NSCLC second-line setting. Clinical trial identification NCT03184571. Legal entity responsible for the study BerGenBio ASA. Funding BerGenBio ASA. Disclosure J.M. Trigo Perez: Advisory / Consultancy, Speaker Bureau / Expert testimony, Travel / Accommodation / Expenses: Roche; Advisory / Consultancy, Speaker Bureau / Expert testimony, Travel / Accommodation / Expenses: AstraZeneca; Advisory / Consultancy, Speaker Bureau / Expert testimony, Travel / Accommodation / Expenses: Boehringer; Advisory / Consultancy, Speaker Bureau / Expert testimony, Travel / Accommodation / Expenses: BMS; Advisory / Consultancy, Speaker Bureau / Expert testimony, Travel / Accommodation / Expenses: MSD. E. Felip: Advisory / Consultancy, Speaker Bureau / Expert testimony: AbbVie; Advisory / Consultancy, Speaker Bureau / Expert testimony: AstraZeneca; Advisory / Consultancy, Speaker Bureau / Expert testimony: Blueprint Medicines; Advisory / Consultancy, Speaker Bureau / Expert testimony: Boehringer Ingelheim; Advisory / Consultancy, Speaker Bureau / Expert testimony: Bristol-Myers Squibb; Advisory / Consultancy, Speaker Bureau / Expert testimony: Celgene; Advisory / Consultancy, Speaker Bureau / Expert testimony: Eli Lilly; Advisory / Consultancy, Speaker Bureau / Expert testimony: Guardant Health; Advisory / Consultancy, Speaker Bureau / Expert testimony: Janssen; Advisory / Consultancy, Speaker Bureau / Expert testimony: Medscape; Advisory / Consultancy, Speaker Bureau / Expert testimony: Merck KGaA; Advisory / Consultancy, Speaker Bureau / Expert testimony: Merck Sharp & Dohme; Advisory / Consultancy, Speaker Bureau / Expert testimony: Novartis; Advisory / Consultancy, Speaker Bureau / Expert testimony: Pfizer; Advisory / Consultancy, Speaker Bureau / Expert testimony: Roche; Advisory / Consultancy, Speaker Bureau / Expert testimony: Takeda; Advisory / Consultancy, Speaker Bureau / Expert testimony: Touchtime. A. Helland: Speaker Bureau / Expert testimony, Research grant / Funding (institution): AstraZeneca; Speaker Bureau / Expert testimony, Research grant / Funding (institution): Roche; Speaker Bureau / Expert testimony: MSD; Speaker Bureau / Expert testimony: BMS; Speaker Bureau / Expert testimony: PierreFabre; Speaker Bureau / Expert testimony: Pfizer. E. Arriola: Advisory / Consultancy, Speaker Bureau / Expert testimony, Research grant / Funding (institution), Travel / Accommodation / Expenses: BMS; Advisory / Consultancy, Speaker Bureau / Expert testimony, Research grant / Funding (institution), Travel / Accommodation / Expenses: Roche; Advisory / Consultancy, Speaker Bureau / Expert testimony, Travel / Accommodation / Expenses: MSD; Advisory / Consultancy, Speaker Bureau / Expert testimony, Research grant / Funding (institution): Pfizer; Advisory / Consultancy, Speaker Bureau / Expert testimony, Travel / Accommodation / Expenses: Lilly; Advisory / Consultancy, Speaker Bureau / Expert testimony: AstraZeneca; Advisory / Consultancy, Speaker Bureau / Expert testimony: Boehringer Ingelheim. R. Garcia Campelo: Advisory / Consultancy, Speaker Bureau / Expert testimony: Roche/Genentech; Advisory / Consultancy, Speaker Bureau / Expert testimony: MSD Oncology; Advisory / Consultancy, Speaker Bureau / Expert testimony: AstraZeneca; Advisory / Consultancy, Speaker Bureau / Expert testimony: Bristol-Myers Squibb; Advisory / Consultancy, Speaker Bureau / Expert testimony: Pfizer; Advisory / Consultancy, Speaker Bureau / Expert testimony: Novartis; Advisory / Consultancy, Speaker Bureau / Expert testimony: Takeda; Advisory / Consultancy, Speaker Bureau / Expert testimony: Boehringer Ingelheim. J. Spicer: Honoraria (institution), Research grant / Funding (institution): AstraZeneca; Honoraria (institution), Research grant / Funding (institution): Bayer; Honoraria (institution), Research grant / Funding (institution): BerGenBio ASA; Honoraria (institution), Research grant / Funding (institution): Boehringer Ingelheim; Honoraria (institution), Research grant / Funding (institution): BMS; Honoraria (institution), Research grant / Funding (institution): Curis; Honoraria (institution), Research grant / Funding (institution): Genmab; Honoraria (institution), Research grant / Funding (institution): Roche; Honoraria (institution), Research grant / Funding (institution): Starpharma; Honoraria (institution), Research grant / Funding (institution): Taiho; Shareholder / Stockholder / Stock options: IGEM Therapeutics. R.J. Holt: Full / Part-time employment: BerGenBio ASA. J.B. Lorens: Leadership role, Research grant / Funding (institution), Shareholder / Stockholder / Stock options, Full / Part-time employment: BerGenBio ASA. M. Shoaib: Advisory / Consultancy, Full / Part-time employment: BerGenBio ASA. A. Siddiqui: Advisory / Consultancy, Full / Part-time employment: BerGenBio ASA. E.V. Schmidt: Full / Part-time employment: Merck Sharp & Dome. M.J. Chisamore: Full / Part-time employment: Merck Sharp & Dome. M.G. Krebs: Honoraria (institution), Advisory / Consultancy, Research grant / Funding (institution): Roche; Advisory / Consultancy: Achilles Therapeutics; Advisory / Consultancy: Octimet; Advisory / Consultancy: Janssen; Travel / Accommodation / Expenses: AstraZeneca; Travel / Accommodation / Expenses: BerGenBio ASA. All other authors have declared no conflicts of interest.


The National Immunization Surveys (NIS) are large random-digit-dial (RDD) telephone surveys to assess vaccination coverage in the United States among children age 19-35 months (NIS-Child) and adolescents age 13-17 years (NIS-Teen), and to assess influenza vaccination coverage among children 6 months-17 years (NIS-Flu). Among working telephone numbers in the RDD samples, the most common NIS call outcome is reaching a potential respondent's answering machine or voicemail. When messages are left for the respondent, under the standard NIS procedure, the message is left live by the interviewer making the call. An alternative is the use of a pre-recorded message. Relative to a live message, a pre-recorded message should result in a reduction in interviewer time, potentially improving the cost-effectiveness of survey administration, as the interviewers will no longer be spending time leaving messages. A pre-recorded message could also affect response rates, either positively or negatively. The use of a pre-recorded message allows for more control over the clarity, pacing, and vocal characteristics of the message left and therefore could result in higher response rates on subsequent calls. However, if the respondent can tell the message is a recording, response rates could suffer. Beginning in Quarter 4 of 2017, an evaluation was conducted in the NIS-Child, NIS-Teen, and NIS-Flu to examine the impact of pre-recorded messages on interviewer time and on response rates. Households were randomly assigned to receive either a live message (control group) or one of four versions of a pre-recorded message (experimental group) when a respondent's answering machine or voicemail was encountered. Pre-recorded messages differed by the age and gender of the person recording the message. We examined the interviewer time spent on calls on which messages were left and compared post-message contact rates among the control group and treatment groups. We found that the use of pre-recorded messages significantly reduced interviewer time spent on these calls compared with live messages, and we found similar post-message contact rates between pre-recorded and live messages in both the landline and cell-phone samples. Postmessage contact rates did not differ by the age of the person recording the message. Postmessage contact rates were significantly higher for female recorded voices than male recorded voices in the landline sample but not in the cell-phone sample. We speculate that this may be due to the availability of message transcription on many cell-phone devices. In this paper, we present the study design, study results, conclusions, limitations, and recommendations for future research.


In next generation wireless networks, a variety of heterogeneous radio access technologies are expected to be available simultaneously within a single wireless terminal. This paper addresses the challenge of link aggregation in multi-access networks, where a key issue is how to optimally aggregate bandwidth offered by the individual radio link. Effective link throughput model is employed as a common resource measure for heterogeneous links. Based on the model, we present a packet allocation technique to optimize link aggregation. The mapping of packets to radio access links is performed to maximize the overall expected system throughput. Airtime constraint is added for an equal load balance. We have conducted extensive simulations with two scenarios. One is at the co-existence of WiMAX and WiFi, and the other includes only WiFi links. The proposed technique adaptively operates to time-varying link resource, and achieves better the aggregated link performance than WRR with fixed distribution ratio.


A stent mechanism, the mechanism comprising a substrate holder, a support member and a support arm, one end of the support arm is rotatably mounted on the support member, an end of the support member is rotatably mounted on the substrate, the bracket means includes two further away from each other may be disposed on the substrate holder, each clamp member defines a plurality of recesses, and the facing recess provided corresponding to both sides of the other end of the support arm, respectively, is provided with a projecting lock pin, the lock pin is slidably disposed between the clamping member and the two locking pins releasably locking a pair of grooves in the support member so that the resting on the substrate.


The dynamic response behavior of red blood cells holds the key to understanding red blood cell related diseases. In this regard, an understanding of the physiological functions of erythrocytes is significant before focusing on red blood cell aggregation in the microcirculatory system. In this work, we present a theoretical model for a photoacoustic signal that occurs when deformed red blood cells pass through a microfluidic channel. Using a Green's function approach, the photoacoustic pressure wave is obtained analytically by solving a combined Navier-Stokes and photoacoustic equation system. The photoacoustic wave expression includes determinant parameters for the cell deformability such as plasma viscosity, density, and red blood cell aggregation, as well as involving laser parameters such as beamwidth, pulse duration, and repetition rate. The effects of aggregation on blood rheology are also investigated. The results presented by this study show good agreements with the experimental ones in the literature. The comprehensive analytical solution of the extended photoacoustic transport model including a modified Morse type potential function sheds light on the dynamics of aggregate formation and demonstrates that the profile of a photoacoustic pressure wave has the potential for detecting and characterizing red blood cell aggregation. © 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement OCIS codes: (110.5125) Photoacoustics; (000.3860) Mathematical methods in physics; (000.1430) Biology and medicine. References and links 1. H. A. Cranston, C. W. Boylan, G. Carroll, S. P. Sutera, J. Williamson, I. Y. Gluzman, and D. J. Krogstad, "Plasmodium falciparum maturation abolishes physiologic red cell deformability," Science 223, 400–404 (1984). 2. J. P. Shelby, J. White, K. Ganesan, P. K. Rathod, and D. T. Chiu, "A microfluidic model for single-cell capillary obstruction by plasmodium falciparum-infected erythrocytes," Proc. Natl. Acad. Sci. 100, 14618–14622 (2003). 3. V. M. Ingram, "Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin," Nature 180, 326–328 (1957). 4. D. K. Kaul, M. Fabry, P. Windisch, S. Baez, and R. Nagel, "Erythrocytes in sickle cell anemia are heterogeneous in their rheological and hemodynamic characteristics," J. Clin. Invest. 72, 22 (1983). 5. E. Evans and A. Yeung, "Hidden dynamics in rapid changes of bilayer shape," Chem. Phys. Lipids 73, 39–56 (1994). 6. G. A. Barabino, M. O. Platt, and D. K. Kaul, "Sickle cell biomechanics," Annu. Rev. Biomed. Eng. 12, 345–367 (2010). 7. E. M. Strohm, E. S. Berndl, and M. C. Kolios, "High frequency label-free photoacoustic microscopy of single cells," Photoacoustics 1, 49–53 (2013). 8. E. M. Strohm and M. C. Kolios, "Classification of blood cells and tumor cells using label-free ultrasound and photoacoustics," Cytom. Part A 87, 741–749 (2015). 9. G. He, B. Li, and S. Yang, "In vivo imaging of a single erythrocyte with high-resolution photoacoustic microscopy," Front. Optoelectron. 8, 122–127 (2015). 10. T. Feng, Q. Li, C. Zhang, G. Xu, L. J. Guo, J. Yuan, and X. Wang, "Characterizing cellular morphology by photoacoustic spectrum analysis with an ultra-broadband optical ultrasonic detector," Opt. Express 24, 19853–19862 (2016). Vol. 9, No. 6 | 1 Jun 2018 | BIOMEDICAL OPTICS EXPRESS 2785 #320699 https://doi.org/10.1364/BOE.9.002785 Journal © 2018 Received 26 Jan 2018; revised 21 Mar 2018; accepted 11 Apr 2018; published 23 May 2018 11. A. B. Karpiouk, S. R. Aglyamov, S. Mallidi, J. Shah, W. G. Scott, J. M. Rubin, and S. Y. Emelianov, "Combined ultrasound and photoacoustic imaging to detect and stage deep vein thrombosis: phantom and ex vivo studies," J. Biomed. Opt. 13, 054061 (2008). 12. M. Rui, W. Bost, E. Weiss, R. Lemor, and M. C. Kolios, "Photoacoustic microscopy and spectroscopy of individual red blood cells," in Biomedical Optics and 3-D Imaging, OSA Technical Digest (CD) (Optical Society of America, 2010), paper BSuD93. 13. E. M. Strohm, E. S. Berndl, and M. C. Kolios, "Probing red blood cell morphology using high-frequency photoacoustics," Biophys. J. 105, 59–67 (2013). 14. R. J. Talbert, S. H. Holan, and J. A. Viator, "Photoacoustic discrimination of viable and thermally coagulated blood using a two-wavelength method for burn injury monitoring," Phys. Med. Biol. 52, 1815 (2007). 15. E. Hysi, R. K. Saha, and M. C. Kolios, "On the use of photoacoustics to detect red blood cell aggregation," Biomed. Opt. Express 3, 2326–2338 (2012). 16. T. Wang, S. Nandy, H. S. Salehi, P. D. Kumavor, and Q. Zhu, "A low-cost photoacoustic microscopy system with a laser diode excitation," Biomed. Opt. Express 5, 3053–3058 (2014). 17. H. S. Salehi, H. Li, A. Merkulov, P. D. Kumavor, H. Vavadi, M. Sanders, A. Kueck, M. A. Brewer, and Q. Zhu, "Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies," J. Biomed. Opt. 21, 046006 (2016). 18. E. Aytac-Kipergil, A. Demirkiran, N. Uluc, S. Yavas, T. Kayikcioglu, S. Salman, S. G. Karamuk, F. O. Ilday, and M. B. Unlu, "Development of a fiber laser with independently adjustable properties for optical resolution photoacoustic microscopy," Sci. Rep. 6, 38674 (2016). 19. A. Kamruzzahan, F. Kienberger, C. M. Stroh, J. Berg, R. Huss, A. Ebner, R. Zhu, C. Rankl, H. J. Gruber, and P. Hinterdorfer, "Imaging morphological details and pathological differences of red blood cells using tapping-mode afm," Biol. Chem. 385, 955–960 (2004). 20. I. Dulińska, M. Targosz, W. Strojny, M. Lekka, P. Czuba, W. Balwierz, and M. Szymoński, "Stiffness of normal and pathological erythrocytes studied by means of atomic force microscopy," J. Biochem. Biophys. Meth. 66, 1–11 (2006). 21. M. Fornal, M. Lekka, G. Pyka-Fościak, K. Lebed, T. Grodzicki, B. Wizner, and J. Styczeń, "Erythrocyte stiffness in diabetes mellitus studied with atomic force microscope," Clin. Hemorheol. Microcirc. 35, 273–276 (2006). 22. J. L. Maciaszek, B. Andemariam, and G. Lykotrafitis, "Microelasticity of red blood cells in sickle cell disease," J. Strain Anal. Eng. Des. 46, 368–379 (2011). 23. E. A. Evans and P. L. La Celle, "Intrinsic material properties of the erythrocyte membrane indicated by mechanical analysis of deformation," Blood 45, 29–43 (1975). 24. D. E. Discher, D. H. Boal, and S. K. Boey, "Simulations of the erythrocyte cytoskeleton at large deformation. ii. micropipette aspiration," Biophys. J. 75, 1584–1597 (1998). 25. T. Shiga, N. Maeda, and K. Kon, "Erythrocyte rheology," Crit. Rev. Oncol. Hematol. 10, 9–48 (1990). 26. R. M. Hochmuth, "Micropipette aspiration of living cells," J. Biomech. 33, 15–22 (2000). 27. S. Hénon, G. Lenormand, A. Richert, and F. Gallet, "A new determination of the shear modulus of the human erythrocyte membrane using optical tweezers," Biophys. J. 76, 1145–1151 (1999). 28. M. Dao, C. T. Lim, and S. Suresh, "Mechanics of the human red blood cell deformed by optical tweezers," J. Mech. Phys. Solids 51, 2259–2280 (2003). 29. J. Guck, R. Ananthakrishnan, H. Mahmood, T. J. Moon, C. C. Cunningham, and J. Käs, "The optical stretcher: a novel laser tool to micromanipulate cells," Biophys. J. 81, 767–784 (2001). 30. Y. Z. Yoon, J. Kotar, A. T. Brown, and P. Cicuta, "Red blood cell dynamics: from spontaneous fluctuations to non-linear response," Soft Matter 7, 2042–2051 (2011). 31. D. Kilinc and G. U. Lee, "Advances in magnetic tweezers for single molecule and cell biophysics," Integr. Biol. 6, 27–34 (2014). 32. D. A. Fedosov, B. Caswell, and G. E. Karniadakis, "A multiscale red blood cell model with accurate mechanics, rheology, and dynamics," Biophys. J. 98, 2215–2225 (2010). 33. J. Li, G. Lykotrafitis, M. Dao, and S. Suresh, "Cytoskeletal dynamics of human erythrocyte," Proc. Natl. Acad. Sci. 104, 4937–4942 (2007). 34. H. Bow, I. V. Pivkin, M. Diez-Silva, S. J. Goldfless, M. Dao, J. C. Niles, S. Suresh, and J. Han, "A microfabricated deformability based flow cytometer with application to malaria," Lab Chip. 11, 1065–1073 (2011). 35. M. Diez-Silva, Y. Park, S. Huang, H. Bow, O. Mercereau-Puijalon, G. Deplaine, C. Lavazec, S. Perrot, S. Bonnefoy, M. S. Feld et al., "Pf155 resa protein influences the dynamic microcirculatory behavior of ring-stage plasmodium falciparum infected red blood cells," Sci. Rep. 2, 614 (2012). 36. C. Dubus and J.-B. Fournier, "A gaussian model for the membrane of red blood cells with cytoskeletal defects," Eur. Lett. 75, 181 (2006). 37. E. M. Strohm, I. Gorelikov, N. Matsuura, and M. C. Kolios, "Modeling photoacoustic spectral features of micron-sized particles," Phys. Med. Biol. 59, 5795 (2014). 38. R. K. Saha, S. Karmakar, A. Adhikari, and M. C. Kolios, "Photoacoustic field calculation for nonspherical axisymmetric fluid particles," Biomed. Phys. Eng. Express 3, 015017 (2017). 39. M. Musielak, "Red blood cell-deformability measurement: review of techniques," Clin. Hemorheol. Microcirc. 42, 47–64 (2009). Vol. 9, No. 6 | 1 Jun 2018 | BIOMEDICAL OPTICS EXPRESS 2786


This article presents an evaluative experience of the Team Development Program with Senac teachers in the state of Ceara. Conducted by researchers and experts, it adopted the four-pole methodology of De Bruyne, Herman & Schoutheete, with the thinking of Dewey, Kilpatrick & Schon as its epistemological pole. The theoretical field explored the development of teams and the evaluation of educational programs. A morphological axis demonstrated the Team Development Program (Prode) model. And, in the technical pole, the results of the evaluation were demonstrated from the perception of the facilitators and the teachers.


The device classified into a plurality of categories, the media key and device key data belonging to each category holding device, for each category generates a device key for each category of the particular device held invalid invalidation data, and recorded on a recording medium.


Abstract : The investigation was conducted on six selected fabrics to determine the relationship of breaking load, elongation and tear strength of fabrics to the properties of the component yarns. A system for expressing fabric properties as ratios of the contributing yarn properties was developed. Two factors termed cloth assistance factor (CAF) and cloth elongation factor (CEF) were used to characterize the effect of thread crossings in the fabric structure. These two factors show a linear relationship. It was concluded that the excess of fabric strength and elongation over that of yarn strength, elongation and crimp was due to the crossing threads effectively reducing the lengths of yarn elements in the test specimen thus localizing the rupture mechanism. Fabric tear strength and yarn strength were related through a third factor called tear efficiency factor (TEF). This factor defines the relationship between warp and filling tear strengths of the fabric in terms of the yarn strengths and threads per inch.


Membrane holder for the membrane adsorber comprising a housing body (12) having a receiving space for at least one layer of adsorber membranes (22) and wenistens a mti the housing body (12) fixable first housing cap (34) for completing a first receptacle opening, wherein an Flusigkeitsstrom via first Flussigkeitsleitmittel (36) through the first housing cap (34) and the first Aunahmeraumoffnung is such in the receiving space can be introduced, that it passes through the adsorber membranes (22) and flows through a second receiving chamber opening, the first housing cap (34) as a first union nut to the housing body ( 12) can be screwed and a first punch member (24) via a first receiving space opening outstanding flange (32) (between the first housing cap 34) and the housing body (12) is clamped sealingly in a basket-like, the recording of the adsorber membranes (22 ) serving insert (14) with fluid-tight is fixable ter wall and a perforated bottom (18), wherein an outer contour of the basket-like insert (14) is adapted in a sealing manner to an inner contour of the receiving space.


Objective To establish a rapid, specific and sensitive molecular method for the detection of genogruop Ⅰ of norovirus using TaqMan-MGB probe-based real-time fluorescent polymerase chain reaction, and to provide credible molecular evidence for disease control and prevention. Method According to the genogroupⅠconserved sequence of norovirus, specific primers and TaqMan-MGB probe were designed, and were optimized to establish one step real-time RT-PCR system. The specificity, sensitivity and repeatability of this system were evaluated and compared with the conventional RT-PCR. Result The one step TaqMan-MGB probe-based real-time RT-PCR for genogruopⅠof norovirus was so rapid that it can be reported in just an hour, and the sensitivity was 100 copies per reaction, and there was no non-specific cross reaction with other viruses, including rotavirus, adenovirus, astrovirus, hepatitis A virus and the genogruopⅡof norovirus. Five samples containing different concentration of norovirus were tested for 5 times, and the coefficient of variability for the average of Ct values were 0.39%~1.02%. Conclusion The rapid, specific, sensitive and repeatable one step TaqMan-MGB probe-based real-time RT-PCR for the detecting genogruopⅠ of norovirus was successfully established, and could be applied to improve the capacity of rapid detection for the emergency process to the abrupt public hygiene affairs or regular surveillance.


Cauchy problem for Laplace equation in a strip is considered. The optimal error bounds between the exact solution and its regularized approximation are given, which depend on the noise level either in a Holder continuous way or in a logarithmic continuous way. We also provide two special regularization methods, that is, the generalized Tikhonov regularization and the generalized singular value decomposition, which realize the optimal error bounds.


We prove that the systolic ratio of a sphere of revolution $S$ does not exceed $\pi$ and equals $\pi$ if and only if $S$ is Zoll. More generally, we consider the rotationally symmetric Finsler metrics on a sphere of revolution which are defined by shifting the tangent unit circles by a Killing vector field. We prove that in this class of metrics the systolic ratio does not exceed $\pi$ and equals $\pi$ if and only if the metric is Riemannian and Zoll.


Abstract : The Joint Internation Symposium on Molten Salts was held 18-23 October 1987 in Honolulu, HI. Topics emphasized include fundamentals and applications of room-temperature haloaluminates, molten salt batteries, molten-metal solutions and their application to extractive metallurgy by electrochemical techniques, and nuclear processes utilizing molten salts media. The symposium on Spectroelectrochemistry and Electroanalytical Science was held at the joint meeting of the Electrochemical Societies of the United States and of Japan. The symposium incorporated work directed toward obtaining information about the electrode/solution interface and the adjacent solution, including spectral probes of the electrode surface and diffusion layer and electrochemical methods for analyzing solutions.


A new class of compact, high-<inline-formula> <tex-math notation="LaTeX">$Q$ </tex-math></inline-formula>, tunable coaxial filter is presented in this article based on a novel inset resonator concept. The tuning concept is based on the displacement of movable resonators inside a properly modified metallic housing which features wide tuning capabilities and stable high <inline-formula> <tex-math notation="LaTeX">$Q$ </tex-math></inline-formula>-factor performance with minimum variation throughout the tuning window. Various prototypes are designed and implemented to demonstrate and validate the proposed concept. A single tunable inset resonator is first designed and measured showing distinctive results of a 43% tuning range, stable high-<inline-formula> <tex-math notation="LaTeX">$Q$ </tex-math></inline-formula> of 4100% ± 4%, spurious-free band up to <inline-formula> <tex-math notation="LaTeX">$3.8\times f_{0}$ </tex-math></inline-formula>, and volume-saving up to 50% when compared with the conventional combline and half-wavelength structures. The design procedure for constant absolute bandwidth (CABW) tunable filters is then presented, and two different tunable inset filters are designed and implemented. First, a manually tunable four-pole filter is demonstrated with the merits of a wide 39.3% tuning range, while maintaining a constant bandwidth of 116 MHz ± 6% and a stable high-<inline-formula> <tex-math notation="LaTeX">$Q$ </tex-math></inline-formula> of 1820% ± 6%. Next, an automatically tunable third-order inset filter is designed and measured using high-accuracy piezomotors. Similarly, the measured results exhibit a wide 1.3-GHz tuning range from 2.65 to 3.95 GHz with a stable insertion loss that is less than 0.35 dB, a return loss that is better than 15 dB, and a good spurious performance up to <inline-formula> <tex-math notation="LaTeX">$2.8\times f_{0}$ </tex-math></inline-formula>. To our own knowledge, the proposed tuning technique and tunable components represent state-of-the-art tuning range and stable high-<inline-formula> <tex-math notation="LaTeX">$Q$ </tex-math></inline-formula> with minimal variation when compared with similar loaded-waveguide designs.


Multiple organizational principles have been proposed to classify information in the field of information studies. Hierarchical classification systems are the most familiar, but they require relational consistency between the different levels and mutual exclusivity across classes. Attempts to organize soundscapes within hierarchical classification are challenging for these two reasons. Listening test results suggest that people cross-categorize everyday sounds according to the sound source, the action generating the sound, and/or the context in which these sounds are perceived . Moreover, soundscapes are complex sound scenes with multiple, concurrent sound sources. This paper proposes a faceted taxonomy that reflects the way people cross-categorize sounds. Five facets are used in the taxonomy, each reflecting a fundamental characteristic of the sound: agent, source, action, context, and acoustic features. Within some facets, a hierarchy of terms can be established, and thus the facets must allow for a hierarchical relationship between the terms. This taxonomy will be implemented using a relational database (MySQL) and a web interface for users to navigate the content and structure of the taxonomy. The proposed database will be populated using existing sound datasets, such as freesound.org. In this taxonomy, a soundscape can be described as a set of sounds, eliminating the challenge of isolating a soundscape to one placement in a taxonomy. We will analyze the free format verbal descriptions accompanying each sound in terms of the facets of the proposed taxonomy, and explore new facets from emerging categories. Thus, the proposed taxonomy supports the ongoing efforts to standardize and report soundscape research by offering a way to systematically describe a given soundscape.


Polyaniline (PANI) composite nanotubes (90−130 nm in diameter) containing titanium dioxide (TiO2) nanoparticles (about 10 nm in diameter) were synthesized through a self-assembly process in the presence of β-naphthalenesulfonic acid (β-NSA) as the dopant. It was found that the morphology, size, conductivity, and hydrophobicity of the PANI−β-NSA/TiO2 composite nanotubes were affected by the content of TiO2 nanoparticles in the nanotubes. The micelles composed of β-NSA anions and anilinium cations containing TiO2 were proposed to interpret the formation mechanism of the self-assembled composite nanotubes. The Raman spectra and X-ray diffraction characterizations show that the main chain of the composite nanotubes is identical to that of the doped PANI, and indicate that there is no chemical interaction between PANI and TiO2.


Develop a criterion based upon measuring the amount of power developed in the forcing function F(x,t). The total power in F(x,t) is the product of the "power" in F(x) and f(t) owing to the assumption in equation (i). The scheme in outline is to measure the temporal power and the spatial power in F(x,t) separately then compare the corresponding power in the Ritz modes against power in each component of the forcing. Generation of


Mechanical systems increase our physical abilities (cranes to lift vast amounts, telescopes to see farther, etc.), but intelligent systems are power tools for heavy lifting in the information world-they complement, extend, and amplify our ability to think and solve problems. In this paper we introduce some thoughts and ideas about intelligent medical system design and the use of MetaMet. A specific design approach constructed with MetaMet is presented and discussed.


[Objective]The aim was to study the inheritance of flesh thickness,so as to provide a theoretical basis for breeding of thicker-flesh summer squash variety.[Method]Using mixed major genes and polygene inheritance model,a joint analysis of six generations from two crosses q-1×23-4G(Cross 1)and q-1×A-7(Cross 2)was conducted to investigate the inheritance of the flesh thickness of summer squash.[Result]The results showed that the flesh thickness was controlled by D-2 model(a pair of additive major genes plus additive-dominant polygene);genetic effect of flesh thickness in the two crosses was mainly the dominant effect of polygene.Heritability values of the genes of F2 generation were relatively low,while the environmental effect was great.[Conclusion]To flesh thickness,the method of individual selection on high separated generations was effective in the breeding of summer squash with thick flesh.


This paper presents the preliminary results of the family planning counseling quality measurement study through an analysis of audio-visual taped provider-client interactions in Ghana and Kenya. The main purpose of the study is to compare three different measurements on quality of family planning counseling skills and study the characteristics of the counseling process through transcript analysis. The data sets used were from the counseling training need assessment and post training evaluation studies in Kenya and Ghana respectively. Trained researchers did transcript analyses of taped sessions and five guides were developed. These include interaction analysis guide contraceptive information quality guide decision making inventory nonverbal communication and affective scale and open-ended lead code. Results based on Ghana data indicates that transcript analysis rating of the quality of information is lower than expert observation and client exit interviews; similarity in expert observation and client interview in assessing simple skills; authoritative relationship between provider and client; infrequent expression of client needs and question; and low participation of clients in decision-making. Findings suggest more effort to develop valid assessment measurements while logistics in audio and video taping transcribing rating and analysis is recommended for further studies.


Make your fellowman worry as you yourself worry. In this article Gerard Rabinovitch presents a critical review of Zygmunt Bauman's book Modernity and the holocaust In his work Rabinovitch discusses the central thesis of the book which sees the holocaust as an effect rather than a post-modern barbarity, but modernity itself. On the one hand, Rabinovitch shows the aspects such as the criminal aspect and Nazism that were excluded from Bauman's analysis; on the other, he points out the essential presence of a value of pessimism which emphasizes the uniqueness of this text.


This paper presents research development of water hydraulicsmanipulator testrig for underwater application at Centre for AdvancedResearch on Energy, Faculty of Mechanical Engineering, Universiti Teknikal Malaysia Melaka. The test rig is designed in order to study the effectiveness of using water hydraulics system for underwater manipulation application. With objectives to promote sustainability and energy saving, the manipulator system is targeted for usage in an underwater scenario, possibly on small submarines or underwater remotely operated vehicles (ROVs).Underwater vehicles normally utilize the use of oil hydraulics for propulsion, manipulation and instrument control. The research on underwater manipulator that uses the surrounding sea water itself as the power and energy carrier for control is now possible with the current development in water hydraulics technology.


Most economists, at least when confronted with the issue, would agree that strict selfishness cannot be taken literally as a universal description of the economic agent. For markets to be fully competitive, agents can only be selfish within certain bounds, e.g. they have to respect basic property rights. Also, most employment relationships rely on mutual trust and cooperation. Yet, the selfish, or self-centered, agent has been the fundamental behavioral assumption in mainstream economics throughout the 20th century. It is still the dominant explanation of human motivation. Until recently, relatively little attention in mainstream economics has been given to understanding what the bounds or institutions limiting selfishness are, how they have come about and differ across economies. Kuhn (1970) uses the term "paradigm" for the general laws, fundamental assumptions and applied techniques that are shared by the scientists within a scientific program. A paradigm, being the fundamental common framework naturally escapes a precise characterization. However, in my view, the strictly self-centered economic man is part of the neoclassical paradigm; it is a fundamental assumption which is shared by the larger community of mainstream economists. Another basic behavioral assumption is that agents are rational. By this, most economists essentially mean that an agent's choices, i.e., actions, are consistent. More precisely, choice is rational if, given the constraints facing the agent, it is determined by a rational set of preferences and beliefs. Neoclassical economics builds on an axiomatic model of human motivation which, despite their exogeneity, imposes a relatively rigid structure on preferences. In itself this structure is a defining characteristic of rationality the way economists use it (Hausman and McPherson 1996). The axiomatic approach is closely linked to the commitment to mathematics as the language within which economic theories are formulated. The axioms imply that the preferences can be represented by a single-valued function, mea-


—Both in global and local context, cities have become more important politically, economically and socially. With rapid growth of information and communication technology (ICT) over the last decade, human relations have revolutionized, creating new possibilities of encounter and connectivity, as well as the new way for strengthening cities government and citizen relations. The cities government have started to use ICT to foster citizen engagement with broader and deeper contributions in political decision-making process for achieving openness and transparency. Innovative digital and mobile technology facilitate solutions for government to respond demand participation including informing, consulting and engaging citizens during legislation cycle process. However, the development of e-participation in the digital city context still have primary challenge and requires strong vision and commitments from all of the city stakeholders for legislation making process more digitally and participative. This paper tries to elaborates a literature study of conceptual publications on the subject of eParticipation in term of legislation process with the time frame of 2013–2018. Its objectives are to track recent theoretical and practical development in the field, to reveal constraints and limitations the concepts, and to offer some suggestions for city government in Indonesia for developing digital legislation implementation strategy.


Emerging tropical viruses have caused serious outbreaks during the recent years, such as Ebola virus (EBOV) in 2014 and the most recent 2018-19 outbreak in Congo. Immediate diagnostic attention is ...


: According to the 1/4 vehicle body four-degree-of-freedom vertical vibration model of high-speed train, using the theory of random vibration and residue theorem, the root mean square value analytical formulae describing the dynamic response of railway vehicles to random excitations generated by vertical track irregularities are established. The correctness of the analytical formulae is validated by numerical calculation. The results show that the values computed are completely consistent with that simulated in a certain range of effective digital. Furthermore, the reliability of the analytical calculation method is validated by comparison with the whole vehicle simulation. The results show that the maximum relative deviation of the body vertical RMS acceleration computed and simulated is only 12.50%, the maximum relative deviation of the secondary suspension vertical RMS stroke computed and simulated is only 15.47%, thus, the analytical calculation method established is reliable. Based on this, using the golden-section adaptive, the damping design method of secondary vertical suspension is built. This research provides a reference for the initial design of the secondary vertical suspension system parameters of high-speed train.


The stability of InP HEMTs preamplifiers has been investigated in time and frequency domains at various cryogenic temperatures. It achieved a gain fluctuation of 5/spl times/10/sup -6///spl radic/ Hz and an Allan time of 9 seconds at 4 GHz bandwidth. The stability of a sideband separating (2SB) mixer receiver is tested with the IF (4-8 GHz) preamplifier at 4 K.


4. Parabolic Partial Differential Equations ..................................................................................1 4.1 Mass or Heat Transfer from Falling Liquid Film .................................................................1 4.1.1 Continuous Solutions in z ........................................................................................... 4 4.1.2 Numerical Solutions in z ............................................................................................ 13 Basic Methods and Stability ........................................................................................... 14 Stiffness ......................................................................................................................... 18 Runge-Kutta Methods .................................................................................................... 19 Multistep methods .......................................................................................................... 23 Comparison of Methods ................................................................................................. 24


On the beach in midsummer, one of the favorite recreational activities for adults and children is to build the castle of the sea sand. However, the castles carefully built by the artists are often ruined by the inflow of waves or rising tides. We built the best 3D model of the sandcastle foundation. Moreover, we found the optimal essential moisture content. Due to the frequent precipitation in summer, our model also provides some reinforcement schemes. we compared the bearing capacity coefficients of several common foundation shapes and obtained the optimal shape on a plane. Then we compared the various indexes of the round table with different stacking angles in the vertical direction. We constructed the evaluation function using hierarchical analysis and then found the optimal stacking angle at the point where the first derivative of the function was zero. When calculating the thickness of the foundation based on a sandcastle with specific gravity, we chose the ordinary column foundation bearing capacity formula as the bearing capacity formula of the circular table foundation. Furthermore, we use this formula to find the corresponding thickness of the foundation in combination with the optimal stacking angle previously obtained.


Globally, cities have made efforts to shift to low-carbon emission development (LED), amidst air pollution, greenhouse gas (GHG) emissions, and high temperature anomalies. However, the emphasis on cities to help shift the global economy to LED has been on a single individual sector approach operating in silos rather than the inter and intra-specific outcomes of multiple sectors. Thus, there are uncertainties of adopting suitable pathways for cities' transition to LED, due largely to data paucity and policy incoherence, constrained further by barriers to integrating science, policy, and practice. Hence, the need for cities to take advantage of the benefits of multi-directional perspectives of multiple sectors acting together—the "multi-vector" approach, to confront key questions of climate compatible development (CCD) that support LED. Therefore, the paper extends the development narratives of the CCD approach to an "enhanced" climate compatible development (EnCCD) pathway with in-built questions and determinants to scope cities' transition to LED. The EnCCD suggests that the standalone intersection between mitigation and development to deliver LED will not result in cities' resilience unless (i) co-benefits, which are outcomes of mitigation and adaptation, and (ii) climate-resilient development, the product of adaptation and development, coevolved. Therefore, the EnCCD transforms the development policy focus of cities on separate, single-purpose sectors, such as energy or transport, into multi-sector portfolios having synergistic benefits of mitigation, adaptation, and development strategies.


It is demonstrated that shielded foams can be efficiently used as millimetre-wave waveguides. Experimental examples are provided and discussed with respect to standard planar or waveguide techniques in the 26-40 GHz frequency range. A 2% bandpass foam-waveguide filter is designed, with an insertion loss of /spl sim/-3.2 dB at 28.7 GHz.


Objective: Aiming to evaluate whether navigation aided surgery? offers any advantages over the conventional technique, a randomized, prospective, comparative study was carried out, analyzing the placement of components, alignment of the limb, surgical time, blood loss and functional rehabilitation. Material and methods: We studied 39 patients submitted to 42 Total Knee Arthroplasties. In group 1 (n = 21) the surgery was navigated and in group 2 (n = 21) it was conventional. The patients were evaluated on panoramic radiographs of the lower limbs, CT scan and the Knee Society Score (KSS) preoperatively and three months postoperatively. Surgery time and postoperative blood loss were also evaluated. Results: Surgery time was longer in group 1. There was no significant difference in blood loss and the KSS. There was a greater proximity of the three degrees of external rotation and the five degrees of tilt in the coronal in group 2. The mechanical axis was closer to zero degree in group 1. Conclusions: Navigation promotes individualizing of the positioning of the components of the prosthesis, and offered advantages in limb realignment, compared with traditional methods. The surgerytime has a tendency to be higher in group 2, but this difference is not statistically significant. There were no differences between the groups in relation to blood loss and improvement in KSS. Level of Evidence: Level I, therapeutic studies.


For the multisensor system with correlated measurement noises,unknown noise statistics and different measurement matrices with identical right factor,by correlated method,the online identifiers of the noise statistics are obtained.Based on ARMA innovation model,a self-tuning weighted measurement fusion Kalman filter is presented,which avoids Lyapunov and Riccati equations,reduces the computational burden and is suitable for real time application.By dynamic error system analysis(DESA) method,it is strictly proved that the proposed self-tuning fused Kalman filter converges to the corresponding optimal fused Kalman filter with probability one or in a realization,i.e.it has asymptotic global optimality.A simulation example for a target tracking systems with 3 sensors shows its effectiveness.


Objective To investigate the effects of pioglitazone,a peroxisome proliferation activated receptor(PPAR)γ agonist on oxidative stress process and the therapeutic effects on severity of acute pancreatitis(AP).Methods Thirty male Sprague-Dawley rats were randomly divided into five groups with 6 in each:control group,eerulein plus pioglitazone group,cerulein group,cerulein plus vehicle group,cerulein plus pioglitazone and GW9662 group.Rats were sacrificed at 30 min after the induction of pancreatitis.Pathologic changes of the pancreas were observed under light microscope.The ratios of pancreatic wet/body weight of rat were determined in each group.Serum amylase,pancreatic nitric oxide synthase(NOS),inducible nitric oxide synthase(iNOS),malondialdehyde(MDA),and myeloperoxidase (MPO)were determined by chromometry.Results The serum amylase,pancreatic wet/body weight and the score of pathologic damage increased after the induction of pancreatitis,AP samples were characterized by increased pancreatic MDA,MPO,NOS and iNOS(P<0.01).Pioglitazone(20 mg/kg and 40 mg/kg)exhibited a protective effect against oxygen free radicals reflected by lower serum amylase,less severe pancreatic lesions,normal pancreatic MDA,MPO and NOS levels(P<0.05).GW9662 reversed the effects against oxidative stress of pioglitazone(40 mg/kg)(P<0.05).Conclusions Pretreatment with pioglitazone may exert its therapeutic effect on AP by lowering pancreatic oxidative free radicals and reducing pancreatic tissue infiltration of neutrophils.

Key words:
Acute panereatitis Pioglitazone Oxidative Stress


This study seeks to examine the relationship between rewards and the performance of teachers in the public schools of Ghana.  Using case study approach, data was collected and analysed in terms of descriptive statistics.  Pearson chi square was used to test the significance of relationship between rewards and performance. The results indicated a high assessment of job performance and also establish a significant relationship between teachers' rewards and job performance. Other motivational factors such as job design and talent management were a contributing factor to the high performance of the teachers. The study recommends that school management initiate additional reward programmes such as free lunch and beneficial loans in order to increase the performance of teachers. Keywords: public school teachers, rewards, motivation, performance


The fast development of livestock and aquaculture has prompted an increase in physiological stress and amplified the potential risk of disease epidemics in birds, animals and fish, which results in production losses and hindered the viable development of the industry. In these circumstances, antibiotics are habitually the primary choice for therapy and prophylaxis of animal. Sub therapeutic dosages of antibiotics have frequently been used to animal feed to stimulate growth, This contributes to drug resistance [1]. The European Union is prohibiting the use of all preventive antibiotics as a growth promoter for animal nutrition. However, antibiotics abuse results in various problems such as the occurrence of antibiotic resistance genes, immune suppression in animals, ecological threats and food safety issues [2]. So, nutritionists and researchers are now being forced to look for alternatives to antibiotics to enhance the animal growth, or at least significantly reduce the number of antibiotics added in feed to maintain effective animal production and be able to produce safe meat and eggs [3].


The religious tradition, too often homogenized under the label of "Christian," is anything but homogenous. As a Catholic-Christian, baby-boomer cleric with an admitted inclination to be a provocateur, I find the label of "Christian" as problematic as it is useful. The celebrated biblical scholar Raymond Brown shattered the univocal nature of emerging Christianity in a book that impertinently touted the multiple "churches" that the apostles left behind (Brown 1984). Patristics scholar Robert Wilken dissuades us from thinking about Christianity as born in uniformity and evolving into pluriformity. The opposite was true: Christianity was born in diversity and in many ways became more uniform (Wilken 1971). As a colleague once reminded me, Jesus' name was posted in three languages on the cross. Christianity was anything but univocal in its origins. While pluriform to its roots, emerging Christianity from its backwater origins to the present day has also been marked by certain key, reoccurring practices; from such practices beliefs and doctrines evolved. Rather than falling into unhelpful binaries when interpreting Christian origins and development,1 it is possible to recognize reoccurring dynamics in Christian "traditions" without homogenizing them. In the language of Paul Gilroy, there are detectable "flows" (Gilroy 1993, 16 et passim) in Christian practices and beliefs that mark this religious tapestry across time and territory. One of those flows concerns the centrality of the body to this religion.


ABSTRACT The author was based at the Educational Television Centre in Tel‐Aviv with a remit to study the development of educational television in Israel from its inception in 1966. The article briefly discusses the political and technological factors which led to the development of an educational television channel in Israel. At that time television in Israel consisted solely of educational television broadcasts in the mornings and afternoons. This was extended when the Israeli Broadcasting Authority started to broadcast on the one Israeli channel in the evening slot. The article concentrates on the recent development of educational television and its bid for a new niche in the constellation of Israeli broadcasting. Inevitably the development and future of educational broadcasting is intimately linked with Israel's religious and political schisms and its military and cultural preoccupations. At the moment Israel still only has one television channel, although test programming has been piloted on a second ...


In an organization, most management system has strong relation to the personel management system, such as the management system of personel salary, personel post, instrumentaion, cloth, etc. A design of automatic management network, which based on the personel management system, is presented in this paper. Some detail of the cloth management system is given for example. The program for the network has been in regulary performing successly.


PURPOSE
To differentiate lesion patterns in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) from those in patients with sporadic subcortical arteriosclerotic encephalopathy (sSAE).

MATERIALS AND METHODS
Magnetic resonance (MR; T2-weighted and fluid-attenuated inversion-recovery) images obtained in 28 patients with CADASIL were compared with images obtained in 24 patients with sSAE by using an automated pixel-based group comparison with statistical parametric mapping and regional semiquantitative rating.

RESULTS
Visual rating showed higher lesion scores for CADASIL in the temporal and temporopolar white matter (WM). Statistical parametric mapping group analysis independently revealed more extensive bilateral involvement of the anterior temporal and superior frontal WM in CADASIL. There were bilateral signal intensity reductions within the dentate nucleus, deep cerebellar WM, crus cerebri, and thalamus. Lesions extended remarkably more often into arcuate fibers in the temporopolar and paramedian superior frontal lobes in CADASIL. Linear discriminant analysis was used to classify 96% (50 of 52) of the cases correctly, with temporopolar WM and arcuate fiber involvement contributing most to the discrimination function.

CONCLUSION
The presented MR imaging criteria are useful in the diagnostic work-up in patients with leukoencephalopathy and help to differentiate CADASIL from sSAE. The observed pattern of vulnerability in CADASIL suggests future directions for research in the pathophysiology of this disorder. In addition, the study demonstrates the potential of automated image analysis to explore MR imaging lesion patterns.


Complexes 7ak−an, 7bk,bm [(R1NC(R2)−C(R3)O)Fe(CO)2PR3 a:  R1 = tBu, R2 = H, R3 = Ph; b:  R1 = Me, R2 = Ph, R3 = Ph; k:  R = OMe; l:  R = Ph; m:  R = Et; n:  R = nPr], and 7ao,bo [(R1NC(R2)−C(R3)O)Fe(CO)Ph2PCH2CH2PPh2] have been prepared by substitution of CO in the respective tricarbonyl complexes 1a,b at room temperature. Various dynamic processes have been investigated by 13C and 31P NMR. On the IR time scale, complex 7bk exists in two distinct isomeric forms. Complexes 7 have been characterized by IR, UV−vis, and 1H, 13C, and 31P NMR spectroscopy. Surprisingly, in the 1,3-dipolar cycloaddition reaction of complexes 7 with the dipolarophiles dimethyl acetylenedicarboxylate (DMAD, v), methyl propynoate (w), phenyl acetylene (x), and p-methoxyphenyl-isothiocyanate (y) the bicyclic ferra[2.2.1] complexes 8, i.e., the initial cycloadducts, are stable and isolable. With dimethyl maleate (z) it is formed reversibly. Complexes 8 containing one phosphorus ligand are formed as two non-interconverting isomers. Th...


The development of new, high performance filter media for Automotive oil filtration is an important issue for car suppliers. However, as of now knowledge of decisive, micro scale filtration processes is still limited and the relative importance of many static and dynamic process parameters remains unclear. This work represents an extensive attempt to push the field of fluid filter fibre design forward, away from being a strongly experimental based, trial and error scheme. Thus a micro scale, deterministic filtration solver has been developed using the Open Source, C++ based, computational fluid dynamics tool box OpenFOAM®. The new simulation tool models fluid, fibre and dirt particle interactions as well as dirt particle deposition processes within the framework of realistically reconstructed, microscopic fibre geometries. By statistically averaging the micro scale calculations, the filtration solver can derive some of the most important, macroscopic filtration parameters, such as pressure drop, particle penetration depth and filter fibre efficiency. While other, related publications [1, 30] deal with the simulation of fibre deformation effects, this thesis presents the novel Eulerian – Lagrangian dirt particle and deposition model behind the filtration solver. The particle model is capable of handling, spherical and non-spherical, discrete dirt particles as well as their relevant, dynamic interactions with the fibres, the fluid and among each other. Single particle hydrodynamics are resolved by several fluid calculation cells. The software has already proven to be useful far beyond the field of filtration application and thus represents a completely new tool for Lagrangian, non-spherical particle simulation. In the course of this work the model is scientifically laid out and its physical as well as numerical background is explained. In order to qualitatively and quantitatively validate the results, an extensive experimental set up has been created and a semi-empirical validation scheme has been devised. In addition to that a novel macroscopy method to visualize and digitally evaluate three dimensional dirt particle distributions in filter fibre samples can be presented. To conclude, some revealing examples of solver functionality, plausibility and possible future application are given. New insights provided by this development can now lead to a much better understanding of the filtration process as a whole and might define the direction an efficient, future, material development procedure will have to take.


Bioelectrical impedance analysis is a promising method in determining the body compartments in haemodialysis patients. In this study, we aimed to investigate the agreement between two widely used methods: the single‐frequency and multi‐frequency bioelectrical impedance analyses.


Inflation targeting occured for coping with the inflation and providing price stability after 1990s. In addition it started to have an application in developing and developed countries. Inflation targeting attributes to countries for providing stability by improving the monetary policy. In this study the success of this policy was evaluated in those developing and developed countries. The results of this study showed that it successful in decreasing the rate of inflation of developing and developed countries. During the period in which this policy was applied inflation targeting approach it was observed that it made positive contributions to growth rate in developed countries.


Abstract The Major Highlands of Abruzzo is one of the largest and best preserved areas with marsh vegetation in the Apennines. Fairly well known similar plant systems extend from the Umbrian-Marche Apennines to those of the Matese. The marshy and wet vegetation of the large sedge vegetation (Magnocaricetalia) of the "Major Highlands of Abruzzo" is analysed. Other ecotonal or transitional plant communities mainly characterised by smaller sedges are also included in this study. Fifteen vegetation types have been identified, belonging to the following higher syntaxa: (1) Magnocaricetalia (Caricetum gracilis, Caricetum vulpinae, Caricetum vesicariae, Galio palustris-Caricetum buxbaumii ass. nova, Caricetum ripariae, Caricetum distichae, and Caricetum paniculatae); (2) Caricetalia davallianae (Carex fusca community); (3) Eleocharito palustris-Sagittarion sagittifoliae (Eleocharitetum palustris); (4) Potentillion anserinae (Carex panicea and C. tomentosa communities, Ranunculo repentis-Caricetum divisae ass. nova, and Ranunculo acri-Caricetum hirtae); (5) Cynosurion cristati (Carex leporina and C. spicata communities). Nine of these communities are new for the investigated area and seven of them are new for the Abruzzo region. Several of the associations are very rare in Central and Southern Apennines and many endangered plant species are linked to them. Nevertheless, these vegetation types are not sufficiently protected today, especially those outside the National Parks.


The Digital Divide is an important issue with serious consequences, individuals affected, society as well as threatens economy and productivity growth of a country. It was believed no longer exists in this 21st century era, amongst adolescents due to internet and smart devices penetration increment in Malaysia. Thus, survey conducted among 292 national secondary students from Hulu Langat district, chosen by using proportional random sampling to seek the possibility of digital divide existence by mean of digital skills between genders. There is no divide exist in digital devices ownership especially smartphones and home internet access. However, there was gender divide in digital skills in all dimensions except for information navigation skills even when gender is controlled. Male students had higher digital skills compared to female, whereby female only higher in information navigation skills. There was gender divide exist as well among urban secondary students, whereby urban male had highly digital skilled in computer operational, internet operational, social and creative skills, whilst urban female digitally skilled in information navigation. However, rural female suffered more in digital divide, whereby they were behind in digital skills level compared to rural male in the three dimensions. These findings indicate more efforts should be taken by the policy makers and authorities in enhancing students' digital skills as well as bridging the digital divide in accommodating them well into today's informative world.


The paper by Bonnen, Hedley, and Schweikhardt provides an excellent framework from which to begin this discussion. The authors do a superb job of reviewing work that has been carried out on the changing role of the nationstate and pointing the direction regarding implications for agriculture. I particularly like the characterization of the nation-state subjected to centrifugal and centripetal forces-forces that, on the one hand, are pushing power away from the nation-state into the international arena and, on the other hand, are pulling power away from the nation-state toward the local or regional arenas. The two supporting papers, by Knudson and Browne on the United States and Seguin on Canada, are essentially case studies dealing with one-half of this equation-the devolution of power to the local level. The second half of the equation, the pulling away of power into the international arena, is nicely framed within the literature review, leaving more specific work in agriculture as a challenge for us all. An aspect of this discussion that warrants much greater attention is the relationship between this issue and the firm, specifically the transnational corporation. A small but also relate issue is that of state-trading enterprise. As a side but related comment, I might say that I first began to think about the notion of the nation-state some thirty years ago, when I read Alex McCalla's insightful article on the wheat duopoly, in which a very interesting interplay takes place between the notion of the firm and that of the nation-state.


Background Substance abuse in adolescents is one of the most serious health problems in Korea. Recently, adolescent's smoking, drinking and drug abuse increasing rapidly. Purposes There were two purposes of this study. First was to describe the development process of a user-centered, web-based expert system for substance abuse prevention with the following objectives: (i) to empower adolescent by informing them how to prevent and manage substance abuse, (ii) to provide evidence-based interventions. Another purpose of this study was to examine the effectiveness of this system on smoking and drinking behaviour in adolescents. Methods Development process included four distinct phases: a needs assessment, analysis, design/development/testing, and the application release. After development of the system, the effectiveness was examined with forty adolescents who were recruited from the community. The non-equivalent control group pretest-posttest design was used. Results The web site was released using the URL: http://www.baejy.com/yebang/. This system includes intervention programmes to relieve substance abuse such as preventive education, cognitive behavioural therapy, assertiveness training, anger management, self confidence training and family therapy. After the 8-week period of intervention, experimental group showed a significant decrease in their smoking and drinking behaviour. Contribution to the Field The result was a web-based expert system for substance abuse prevention with a high degree of usability with an evidence-based intervention. The author believes that this development design will be utilised to create safety education programmes suitable for other safety education programme as well as high-risk populations.


OBJECTIVE
To retrospectively explore the multimodal intraoperative monitoring (IOM) technique during untethering cord procedures in 37 patients between 1 month and 16 years of age with tethered cord syndrome during 2014.

METHODS
All patients were diagnosed as tethered cord syndrome by clinical manifestations and verified by magnetic resonance imaging (MRI). Free and trigger electromyogram (EMG) and transcranial motor-evoked potentials (tcMEP) of extremity muscles and anal sphincters were used to map the nerves and monitor the functional motor integrity continuously.

RESULTS
The monitorability rate was 100 % for nervous mapping, 86.5% (32/37) for extremity muscle tcMEP. In all patients, tcMEP remained stable during surgery, 43.8% (14/32) patients showed a significant postoperative increase of amplitude of tcMEP, none of them patients presented a significant and yet transient neurological worsening.

CONCLUSION
The combined technique of monitoring and mapping may boost the procedural safety, minimize the long-term morbidity and improve the clinical outcomes.


The cultural significance and relationships of societies with natural resources in urban areas constitute an important aspect that is still little explored in ethnoecology. The objective of this study was to describe and analyze the knowledge and practices of urban farmers, and how they categorize and control animals that are considered pests of cultivated plants. The survey was conducted in areas of cultivated vegetables in the vicinity of the Supply Logistics Center of Pernambuco (CEASA) in Recife, the capital of Pernambuco State, in northeastern Brazil. Thirty-three farmers were interviewed, who mentioned 13 animals as pests. The most frequent animal cited as a pest that causes injuries to cultivated plants was the ant, and the most frequent ecological relation cited was cochineals that were described as "mold". The techniques used to control undesired animals are related to the cultural identity of the farmers and the market, resulting in a predominantly utilitarian perception of natural resources.


The results are presented of an initial assessment of the feasibility of solvent extraction for removing coal tar from the subsurface, or for treating contaminated soil excavated at manufactured gas plant (MGP) sites. In situ solvent extraction would involve injection, recovery, and reclamation for reinjection of an environmentally-benign, water-miscible solvent. Both laboratory experiments and engineering evaluations were performed to provide a basis for the initial feasibility assessment. Laboratory work included identification and evaluation of promising solvents, measurement of fundamental properties of coal tar-solvent-water systems, and measurement of rates of dissolution of coal tar in porous media into flowing solvent-water solutions. Engineering evaluations involved identification of common hydrogeologic features and contaminant distributions at MGP sites, and identification and evaluation of possible injection-recovery well deployment schemes.


Seizure is a common presenting symptom of bacterial meningitis. The 1996 AAP guideline for evaluation of children with simple febrile seizures recommends that lumbar puncture be "strongly considered" for infants aged 6 to 12 months and "considered" for children aged 12 to 18 …


Meso-meso linked strapped diporphyrins S(n)(n = 10, 8, 6, 4, 3, 2, and 1) were synthesized by intramolecular Ag(I)-promoted coupling of dioxymethylene-bridged diporphyrins B(n). With decrease of strap length, the absorption and fluorescence spectra and the one-electron oxidation potentials of S(n) changed in a systematic manner, suggesting a progressive increase in electronic communication of two porphyrins.


This paper has the goal to inquire on a relevant aspect of Heidegger�s thought: Attunements; in this case, it is orienting the inquiry toward a book considered his most important work, together with Being and Time: Contribution to Philosophy (From Enowning). We try to elucidate such subject within The Leap, which in the mentioned book refers to the perspective of a new Beginning for the Western Thought


This article introduced the problems and the measurements of improvement during the process of design, developing, testing and researching the G8300 Series diesel engines. The main technologies of the G8300 Series diesel engines were the type selection and performance matching for the turbocharger and aftercooler, including the improvement of camshaft, crankshaft, cooling, fuel and other systems. And the G8300 Series diesel engines also contain the generality of the G6300 Series diesel engines. So that the G8300 Series diesel engines can make the design index meet the requirements of the new diesel engines' types.


The utility model discloses a bimetal composite flanged pipe fitting with ends in flange connection, comprising a bimetal composited pipe nipple and flange connection parts which are coaxially sleeved on one or more connection ports of the bimetal composited pipe nipple in a sealing way; the flange connection part comprises a flange and an anticorrosion alloy gasket ring which is coaxially sleeved on the flange in a sealing way, and the middle part of the sealing surface of the flange is provided with a ring-shaped groove for the anticorrosion alloy gasket ring to be installed; the bimetal composited tube nipple consists of a lined pipe and an outer pipe which is coaxially sleeved on the outside of the lined pipe, and in addition, the lined pipe on the connection port extends out of the outer pipe, and the extending length is not greater than the thickness of the anticorrosion alloy gasket ring; and the outer end surface of the outer pipe is parallel and level to the bottom surface of the ring-shaped groove arranged on the middle part of the flange sleeved thereon. The utility model has simple structure, low manufacturing cost, convenient manufacture, good corrosion resisting property and obvious economic benefit, can effectively solve the problems of high manufacturing cost, narrow promotion and application range, poor corrosion resisting property and the like of the corrosive medium pipe flange.


1. In order to test the suggestion that a dietary excess of leucine may be a precipitating factor in pellagra, rats were fed on diets that provided 15 g leucine/kg in excess of requirements for 7 weeks from weaning. This led to a significant reduction in the concentrations of nicotinamide nucleotides in liver and blood. The effect was only apparent when the diets provided less than a minimally adequate amount of nicotinamide, so that the animals were dependent on the synthesis of nicotinamide nucleotides from tryptophan to meet all or part of their requirements. 2. Urinary excretion of N1-methyl nicotinamide was not a useful indicator of tissue concentrations of nicotinamide nucleotides, and seemed not to be adequately sensitive to differentiate between minimal adequacy and marginal deficiency, as demonstrated by changes in concentrations of nicotinamide nucleotides in liver and blood. 3. The addition of leucine to incubation media for the measurement of enzyme activity in tissue homogenates at concentrations within the physiological range, led to a significant activation of tryptophan oxygenase (L-tryptophan: oxygen oxidoreductase (decyclizing), EC 22.214.171.124) and significant inhibition of kynureninase (L-kynurenine hydrolase, EC 220.127.116.11). The effect on tryptophan oxygenase may not be physiologically significant, in view of the considerable range of activity of this enzyme under normal conditions. However, the inhibition of kynureninase, which was primarily competitive with respect to the substrate, probably is physiologically significant, and was enough for this enzyme to become a probable rate-limiting step in tryptophan metabolism and nicotinamide nucleotide synthesis. Other enzymes of the tryptophan – nicotinamide nucleotide pathway were not affected by the addition of leucine to the incubation medium. 4. Feeding 15 g leucine/kg diet in excess of minimum requirements had no effect on the activities of tryptophan oxygenase or kynureninase in liver homogenates. This may reflect the reversible competitive nature of the inhibition of kynureninase by leucine, and hence be an artefact of the incubation procedure. Rats fed on the high-leucine diets excreted significantly more kynurenine than did control animals, which is evidence of inhibition of kynureninase in vivo. 5. It appears that a dietary excess of leucine, of the order of 15 g/kg above requirements, may be a precipitating factor in pellagra when there is reliance on the synthesis of nicotinamide nucleotides from tryptophan to meet a part or all of the requirements, but not when minimally adequate niacin is available from the diet.


Reforming old teaching method and applying advanced multimedia system, the teaching quality and efficiency were improved obviously. In the paper, how to operate and maintain the system and its function and teaching effect were introduced.


Around the accuracy of the case retrieval in the product configuration design,this paper puts forward a new case retrieval scheme in accordance with the conception of correlation function in extenics.According to the customization demand and the description of the product attributes,the attributes are classified to four kinds and the computing method of the attribute distance is presented based on the correlation function in extenics.The attribute weight is calculated by AHP(Analytical Hierarchy Process).It gives the similarity calculation model and comes up with a specific example to prove the validity of the model.


The instability between the success and failure of herbal treatment for chronic diseases illustrates the lack of understanding in society. For this reason, it is necessary to provide socialization of knowledge about herbal medicines through leaflets that are practical, simple, and easy to accept. This activity targets the people of Denpasar City who suffer from chronic diseases and use herbal medicines. The method used is in discussions with respondents who have or are currently undergoing degenerative disease therapy by utilizing herbal medicines as therapy and distributing leaflets containing information on herbal medicines to respondents who are less precise in understanding herbal medicines. The results of community service, giving handouts to the community, can increase knowledge about herbal treatments for chronic diseases. The use of leaflets can increase understanding of herbal medicines about the content, seek information from doctors/pharmacists as a complementary therapy, and different effects of conventional drugs. Thus, leaflets are essential to increase the rational use of medicines, especially herbal medicines.


Abstract Salt deposits in the Powder River Basin of Wyoming occur in the Late Permian Ervay Member of the Goose Egg Formation which was deposited as a part of a red bed-evaporite sequence. These beds extend from the Williston Basin of North Dakota and Montana across the Powder River Basin to the Alliance Basin of Wyoming and Nebraska. Major salt dissolution events occurred in Late Jurassic and Early Cretaceous, leaving only remnants of the once-extensive Ervay salt. Subsidence of the overlying strata and compensatory depositon at the surface were contemporaneous with subsurface salt dissolution. The presence or absence of Ervay salt and the relationship to overlying syndepositional strata can be mapped using borehole logs and/or seismic data. The earliest dissolution of the Ervay salt in the Powder River Basin occurred in Medial Jurassic time near the Wyoming-Montana border, and in Late Jurassic time far to the southeast, along the Hartville Uplift. The earliest salt dissolution events are postulated to be initiated by local fracturing related to basement tectonics. This fracturing provided conduits for groundwater circulation which slowly removed the Ervay salt by dissolution. Dissolution ceased when the salt in the Ervay was locally completely removed or when groundwater circulation ceased in response to sealing of the system by the deposition of transgressive marine Mowry and Belle Fourche shales. One area escaping extensive dissolution in the Late Jurassic and Early Cretaceous was on the eastern Belle Fourche Arch, which extends in a northeast trend across the middle of the Powder River Basin. Here the Morrison, Lakota, and Dakota Formations are thin over areas with underlying Ervay salt, but thicken rapidly in areas of salt collapse. In a 12 township study area along the southern margin of the Belle Fourche Arch, borehole logs from more than 500 wells which penetrate Permian strata document rapid changes in the Ervay salt and overlying Mesozoic strata. In the Powder River Basin, many fields that produce from the Dakota, Muddy, and Mowry Formations exhibit either rapid stratigraphic changes caused by syndepositional salt dissolution or fracture-enhanced reservoir quality due to post-depositional salt collapse. Major Muddy accumulations occurring in areas of local Ervay salt collapse include Kitty, Hilight, Fiddler Creek, and Clareton fields which have jointly produced over 172 million barrels of oil. The relationship between Ervay salt dissolution-collapse events and Early Cretaceous depositional trends can be exploited as an effective exploration tool.


- Design concepts to reduce RTG weights are described. These concepts are m the area of the isotope heat source, the thermoelectric con\er ter, and the radiator. Their effectiveness is demonstrated by means of an illustrative design for a 360-watt, plutonium-fueled generator with spritig loaded selenide elements. The generator, including necessary safety provisiot s for various abort modes, hjs an EOM specific po»pr of T to (i watt'lb


In order to improve short-term storing of skin grafts a new solution, Histocon, was tested. This solution has earlier been used as a transport medium for biopsies subjected to enzyme histochemical analyses. The capacities of Histocon, isotonic saline and a potassium-enriched Ringer solution to preserve the morphology, chemical components and enzyme proteins of the skin graft, were tested. All solutions were compared with fresh-frozen controls during the test period (2–21 days). With Histocon the morphology was identical with the fresh-frozen controls during the whole test period but both the other solutions produced increasingly marked changes after two days. A smaller loss of stainable chemical components was noted with Histocon than with the other solutions. The enzyme histochemical tests showed that Histocon did not visibly affect the hydrolytic enzyme activities while the other solutions rapidly decreased them. With Histocon, strong diaphorase activity was present for a longer period than that of the ...


Abstract : The problem of shape optimization to minimize stress concentration factors is presented. Design variables are chosen such that optimal configurations can be produced for a cylindrical pressure vessel with an end closure and nozzle intersection. A system model is formed in which the stress gradients are calculated numerically using the finite elements method and optimization is performed by the penalty function technique. Various examples of the design algorithm are presented showing optimal geometries together with plots of boundary stress concentrations for the sequence of designs generated. (Author)


Ronald Coase, the most important economist you've (probably) never heard of, died earlier this month aged 102. One of the two articles that won him the Nobel prize for economics, based on a lecture he gave when he was just 21, was the first rigorous explanation of why companies exist. His answer was that they exist whenever bringing things under one roof cuts the cost of doing business.

Under the auspices of the Royal College of Physicians, a slighter older conclave of the great and the good of British medicine has been pondering a similarly fundamental question: why do hospitals exist? Whereas Coase's answer may turn out to be true for all places and all times, …


Popular data mining methods support knowledge discovery from patterns that hold in binary relations. We study the generalization of association rule mining within arbitrary n-ary relations and thus Boolean tensors instead of Boolean matrices. Indeed, many datasets of interest correspond to relations whose number of dimensions is greater or equal to 3. However, just a few proposals deal with rule discovery when both the head and the body can involve subsets of any dimensions. A challenging problem is to provide a semantics to such generalized rules by means of objective interestingness measures that have to be carefully designed. Therefore, we discuss the need for different generalizations of the classical confidence measure. We also present the first algorithm that computes, in such a general framework, every rule that satisfies both a minimal frequency constraint and minimal confidence constraints. The approach is tested on real datasets (ternary and 4-ary relations). We report on a case study that deals with analyzing a dynamic graph thanks to rules.