While CAR-T cells have demonstrated significant efficacy in the treatment of haematological malignancies, there are many challenges to overcome in developing CAR-T cell therapies against solid tumours. In particular, the scarcity of recognised effective target antigens in solid tumours remains a significant hurdle. Leucine-rich repeat-containing G-protein coupled receptor (LGR5) is a cancer stem cell marker, which mediates important roles in tumor initiation and metastasis. Upregulated LGR5 expression in malignant cell contexts highlights this surface receptor as a promising target for CAR-T cell therapy. In this study, we evaluated the efficacy of LGR5-targeting CAR-T cells against a range of human cancers. We demonstrate that LGR5 is expressed, both in vitro and in vivo, by numerous human cancers, including colorectal, ovarian, hepatic, brain, and pancreatic cancer. LGR5-targeting CAR-T cells effectively kill LGR5-expressing cancer cells in in vitro cytotoxicity assays and display significant anti-tumor activity in vivo when administered at 1, 2 or 3 weeks post-tumor inoculation in a subcutaneous human colorectal cancer xenograft mouse model. Furthermore, LGR5-targeting CAR-T cells that induce primary tumor rejection confer complete protection against a secondary tumor challenge 5 weeks post-T cell transfer. In vivo spatiotemporal distribution and repeated dosing studies demonstrate that LGR5-targeting CAR-T cells accumulate at the tumor site until tumor elimination, do not persist in off-target organs by d28 post-tumor inoculation and are safe and well-tolerated under the conditions tested. Together, these results provide the foundation for furthering the development of LGR5-targeting CAR-T cells for use in the clinic against colorectal cancers and other solid tumours.
 Citation Format: Dylan McPeake, Timona Tyllis, Caitlin Abbott, Jade Foeng, Veronika Bandara, Batjargal Gundsambuu, Elaheh Rohani-Rad, Silvana Napoli, Timothy Sadlon, Simon Barry, Shaun McColl. In vivo efficacy of LGR5-targeting CAR-T cell therapies developed for the treatment of colorectal cancer. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4083.


In the last issue of Competion and Regulation Times, Mark Obren surveyed the literature on likely productivity gains from investment in ultrafast fibre-based broadband networks: he found the theoretical case to be highly complex and gains likely to be very much less than what's frequently claimed. Here Simon Vose reviews a recent international study that examined the quality of the evidence for substantial government subsidies of ultra-fast broadband networks to nearly every home in the country.


Many Spanish republicans carried on with a fierce and active struggle against fascism from their exile. They exhibited their commitment through an intense intellectual activity, usually focused on the developments of the Second World War. Cultural journals were a habitual way of communication. In Chile, one of the most significant journals was Espana Libre (1942-1943), which remains still unknown. This so-called «Spanish republican journal» offered a profuse coverage of war course, by means of multiple articles and reports. Nowadays, it reflects the artistic, political, aesthetic and philosophical concerns that the international armed conflict aroused on the exile community.


The masson pine ecological forest was rebuilt on the island of Xiamen. 44 kinds of broadleaf trees interplanting in the forest were investigated to evaluate their adaptability, growth characteristics and resistance. The results indicated that Schima superba, Acacia mangium and other 13 species were of high adaptability, Eucalyptus grandis×E. urophylla, Acacia mangium and so on 7 species were of good growth characteristics. Combining the visual effects, aesthetics and other aspects of a comprehensive evaluation, Liquidambar formosana, Schima superba, Ficus lacor, Acacia mangium, Cinnamomum japonicum, Ficus microcarpa var. pusillifolia, Elaeocarpus sylvestris, Castanopsis hystrix, Cinnamomum camphora, Eucalyptus grandis ×E. urophylla, Myrica rubra were selected as backbone species for forest form rebuilding.


The pathway model of Mathai (2005) is shown to be inferable from the maximization of a certain generalized entropy measure. This en-tropy is a variant of the generalized entropy of order α, considered in Mathai and Rathie (1975), and it is also associated with Shannon, Boltzmann-Gibbs, Rényi, Tsallis, and Havrda-Charvát entropies. The generalized entropy measure introduced here is also shown to have interesting statistical properties and it can be given probabilistic interpretations in terms of inaccuracy measure , expected value, and information content in a scheme. Particular cases of the pathway model are shown to be Tsallis statistics (Tsallis, 1988) and superstatistics introduced by Beck and Cohen (2003). The pathway model's connection to fractional calculus is illustrated by considering a fractional reaction equation.


In long term practice of rock engineering, the strength and failure rules based on classical elasticity and plasticity theory is always dominated in judging the safety and stability of practical engineering. However, stress-strain relationship is only a certain state of rock mass in loading process, and it is hard to give an accurate evaluation for the engineers especially due to the diversity and divergence of mechanical parameters. For actual loading process of rock mass is always companied with energy dissipation and releasing, in this paper, we put emphasis on the ratio of dissipated energy to overall absorbed energy in the cyclic loading process. From this point of view, three important sections are gained as follows: a) condensing section: the ratio is higher due to the closing effect of original cracks; b): elastic section: the value of ratio sharply goes down and is nearly a constant in the elastic section; c) approaching to failure section: this is a section closely to the failure because the newly cracks occurs ceaselessly and the ratio value becomes higher.


This study aims to explore the impact of learner grade, visual cueing, and control design on children's readingachievement of audio e-books with tablet computers. This research was a three-way factorial design where the firstfactor was learner grade (grade four and six), the second factor was e-book visual cueing (word-based, line-based,and paragraph-based cueing), and the third factor was e-book control mechanism (system-controlled andlearner-controlled). The e-books used in this study were on the topic of six major classes of nutrients and the contentwas created with Adobe Flash CS 5.5. This research was guided by this question: Is there any interaction amonglearner grade, visual cueing, and learner control on children's reading of audio e-books in terms of learningachievement (recall and transfer)? A sample of one hundred and eighty-five fourth and sixth graders joined the study,and participants were assigned into one of these groups randomly. The results showed significant interactions amongthese three factors. The fourth graders found the paragraph-based cueing and system-controlled mechanismadvantageous; however, the sixth graders performed equally well under all different conditions of interface design.The results indicated that the fourth and sixth graders have different characteristics as readers and, by extension,suggest audio e-book design should consider the target readers' cognitive and psychological development.


Severely displaced supracondylar fractures of the humerus in children with coexisting fascial, ligamentous, and capsular disruptions are often difficult to treat. Even if seen within an hour or less after the injury, there is usually considerable softtissue swelling and the radial pulse may be absent. In such cases with marked posterolateral displacement of the distal humeral fragment, the neurovascular bundle usually is stretched over the distal end of the shaft fragment and actually may be damaged by the sharp bone end. There may be mechanical pressure obstructing both the arterial blood supply and the venous return. In addition, irritation of the arterial sympathetic nerve fibers may cause spasm of the brachial artery and its collateral vessels. The most common late complication of this fracture is a reversed carrying angle or gunstock deformity due to an inaccurate reduction of the fracture, usually with medial rotation of the distal humeral fragment. A similar deformity, however, can be produced by a growth disturbance of the trochlear epiphysis. Volkmann's contracture, resulting from ischemia of the forearm musdes followed by partial paralysis and with permanent fibrotic changes in the muscle tissues, is a catastrophe which can be avoided by closely supervised care. Confronted by a markedly deformed fractured elbow and a pulseless, cyanotic, and paresthetic hand, the surgeon must take immediate action. Manipulative reduction followed by skeletal overhead traction, with a Kirschner wire placed transversely through the olecranon, as reported by Smith, is usually the treatment ofchoice in such fractures. Percutaneous pinning by Kirschner wires inserted through the medial and lateral epicondyles into the humeral shaft as described in detail by Jones and Swenson is another approach to this problem. The normally situated ulnar nerve, however, could be injured during the insertion of the medial wire, especially if there is congenital recurring anterior dislocation of the nerve. In the presence of extreme displacement of the fragments and local swelling, Blount suggested that several days of traction with elevation and ice packs may be advisable to allow the swelling to subside sufficiently to permit a manual reduction under general anesthesia. Dunlop's skin traction has been recommended for this initial closed type of treatment. To my knowledge, however, no mention is made in any recently published orthopaedic journal or textbook of the use of vertical transarticular pin fixation for the treatment of such markedly displaced fractures, a procedure that in my experience has been very helpful under certain circumstances.


Magnetic materials are generally synthesized and used as alloys and compounds. They are also stacked as a multilayer film for spintronics device such as a reading-head sensor of a hard disk drive. The evaluation of magnetization is the most fundamental characterization in studies of magnetic materials. Especially, in alloys and compounds involving more than two magnetic elements, a partial magnetization with respect to each element, we call as an element specific magnetization, promises to provide the deeper understanding of their magnetic property. X-ray magnetic circular dichroism (XMCD) in absorption spectroscopy provides an element specific magnetization. As XMCD became increasingly popular, high-magnetic-field environment for XMCD measurements also became very important in order to investigate paramagnetic, antiferromagnetic, and meta-magnetic materials. Under the circumstance, a high-magneticfield XMCD measurement technique of the soft-X-ray regime has been developed using a non-destructive pulse magnet having capability of generating 40 T at the twin helical undulators beamline, BL25SU, of SPring-8. In this review, we first introduce the concept and the technical features of high magnetic field XMCD and then show recent examples of the experiments.


As the SLAM research area matures and the number of SLAM systems available increases, the need for frameworks that can objectively evaluate them against prior work grows. This new version of SLAMBench moves beyond traditional visual SLAM, and provides new support for scene understanding and non-rigid environments (dynamic SLAM). More concretely for dynamic SLAM, SLAMBench 3.0 includes the first publicly available implementation of DynamicFusion, along with an evaluation infrastructure. In addition, we include two SLAM systems (one dense, one sparse) augmented with convolutional neural networks for scene understanding, together with datasets and appropriate metrics. Through a series of use-cases, we demonstrate the newly incorporated algorithms, visulation aids and metrics (6 new metrics, 4 new datasets and 5 new algorithms).


Background: Intravenous (I.V.) low osmolar contrast media (LOCM) is commonly used during computerized tomography CT scan examinations, especially in diagnosis and staging of tumours, trauma and abdominal examinations. Many radiologists are relactant to do enhanced examination if patients had history of penicillin allergy. This study aims to evaluate the incidence of LOCM-related side-effects in patients with penicillin allergy compared to patients without penicillin allergy. Methods and patients: Prospective study of 357 patients examined in CT scan unit in AlYarmouk teaching hospital, 44 of them had history of penicillin allergy, all given i.v. contrast medium (LOCM), and the prevalence of LOCM related side effects calculated for both groups. Results: The prevalence of contrast medium related side effect was 0.64% in patients without history of penicillin allergy, while of the 44 patients with penicillin allergy, no side effects has been encountered. Conclusion: No significant increase in LOCM related side effect was seen in patients with


From the Publisher:
Microsoft Word '97 QuickTorial provides a complete learning package that makes the mastery of software applications both easy and fun. Designed to get users up and running quickly, Microsoft Word '97 QuickTorial allows them to master computer tools with a minimum of time and effort. With numerous screen illustrations and lots of hands-on activities for guidance, readers learn quickly in a straightforward, understanding manner. The section on Webtop Publishing with Word allows users to take advantage of Microsoft Word 97's new Internet capabilities.


Discloses a memory device, comprising: a memory controller; clock input pins, receives a clock signal; first chip select signal input pin, a first received from the memory controller chip selection signal of the row address strobe; second chip select signal input pin, received from the memory controller chip select signal for the second column address strobe; command line input pin, the command line received from the memory controller; column command input pins, from the memory control receiving the column command; a plurality of row address input pins, receives a row address from the memory controller; and a plurality of column address input pins, receives the column address from the memory controller.


The inconspicuous penis encompasses a number of different entities. Over the years, this problem has engendered much controversy and endless discussion by urologists but has remained surprisingly unknown among other medical practitioners. Dr Little raises some of the issues that have led to the controversy concerning the buried penis. (The buried penis is but one of the entities comprising the inconspicuous penis).
 Our paper describes the different types of inconspicuous penis so that pediatricians can recognize the physical manifestation and make the appropriate referral to specialty care.


During the past 2 decades, pivotal response treatment (PRT) has emerged as an evidence-based methodology for intervening with the behavioral, communicative, social, and academic impairments of children with autism. Unlike other highly structured behavioral interventions for autism, PRT emphasizes principles over procedures and focuses on enhancing children's motivation to learn in natural environments. The purpose of the present work is to outline the core principles of PRT and discuss some school-based applications. Information provided herein provides school psychologists with a firm grounding in the basics tenets of this state-of-the-art intervention for children with autism, helping facilitate more effective direct and indirect services for such children at school.


Many algorithms have been created to automatically detect community structures in social networks. These algorithms have been studied from the perspective of optimisation extensively. However, which community finding algorithm most closely matches the human notion of communities? In this paper, we conduct a user study to address this question. In our experiment, users collected their own Facebook network and manually annotated it, indicating their social communities. Given this annotation, we run state-of-the-art community finding algorithms on the network and use Normalised Mutual Information (NMI) to compare annotated communities with automatically detected ones. Our results show that the Infomap algorithm has the greatest similarity to user defined communities, with Girvan-Newman and Louvain algorithms also performing well.


The purpose of the research was to study the linear structure of Belarusian breeding type of Yorkshire pigs based on the analysis of DNA differentiation of microsatellites. The genetic diversity and characterizes the linear structure of Belarusian breeding type of Yorkshire breed pigs are bred in the State Enterprise "ZhodinoAgroPlemElita" in the Minsk region and OAO "Selection and Hybrids Center "Zapadny" in the Brest region have been assessed in the paper. The genetic material of 28 boars was selected and their breed belonging was determined based on the analysis of established microsatellites, genetic diff erences between the lines and the degree of heterozygosity of animals in the lines. It has been established that the studied lines were genetically diff erentiated and were characterized by a high level of genetic diversity. Promising breeding boars of breeding lines in Belarusian breeding type of pigs of Yorkshire breed have been identifi ed and selected. When determining the genetic affi liation of boars to the line using the Assignment test, it was found that 12 out of 19 tested boars of four breeding lines confi rmed their pedigree-linear affiliation in the Selection and Hybrids Center "Zapadny" including 8 out of 11 tested boars in Drug 6805 line and two boars each in the Duchess 3962 and Factor 1573 breeding lines. The same trend was noted in the State Enterprise "ZhodinoAgroPlemElita", where out of the tested 9 animals, 4 boars confi rmed their pedigree-linear affi liation (one each in Drug 6805 line and Dobryi 2313 line, two boars from breeding line No. 1131). The dendograms constructed on the basis of genetic similarity in the population of diff erent breeding lines of Belarusian breeding type of pigs of Yorkshire breed showed the greatest genetic closeness between individual breeding lines. The results obtained can be used in the development of a genetic passport of the breed.


Orogenic belts and sedimentary basins are twins developed in a geodynamic system, which formed a sedimentary basin-orogenic belt system. A sedimentary basin-orogenic belt system is a complex system formed by the interactions of continental blocks and the coupling of different spheres in the lithosphere, both of which are substance cycling systems and energy exchanging systems. The coupling relationships between sedimentary basins and orogenic belts refer to all of their interactions in their formation and evolution. Sedimentary basin-orogenic belt systems are characteristic of the basic Mesozoic-Cenozoic structural pattern in West China. There are two fundamental types of sedimentary basin-orogenic belt systems in West China, i. e. simple-flank-basin sedimentary basin-orogenic belt system and double-flank-basin sedimentary basin-orogenic belt system. Microcontinental amalgamation, multi-cycle tectonic movements and intensive intracontinental tectonic activities are the main geologic setting of the formation and evolution of sedimentary basin-orogenic belt systems in West China. The coupling relationships of sedimentary basin-orogenic belt systems include: (1) enantiomorphous relationship between the uplifting of orogenic belts and the vertical subsiding of sedimentary basins, (2) bi-direction transfer of substance flow and energy flow in the horizontal direction, and (3) intensive interactions between different spheres of the lithosphere. The coupling relationship dynamic model of the sedimentary basin -orogenic belt systems in West China is a C (intracontinental)-subduction, which is an L (Longmenshan)-subduction for the simple-flank-basin sedimentary bain-orogenic belt systems and T(Tianshan)-subduction for the double-flanks-basin sedimentary basin-orogenic belt systems.


Aims. Our aim is to determine the presence and location of the emission from polycyclic aromatic hydrocarbons (PAHs) towards low and intermediate mass young stars with disks using large aperture telescopes.

Methods. VLT-VISIR N-band spectra and VLT-ISAAC and VLT-NACO L-band spectra of 29 sources are presented, spectrally resolving the 3.3, 8.6, 11.2, and 12.6 μm PAH features. Spatial-extent profiles of the features and the continuum emission have been derived and used to associate the PAH emission with the disks. The results are discussed in the context of recent PAH-emission disk
models.

Results. The 3.3, 8.6, and 11.2 μm PAH features are detected toward a small fraction of the T Tauri stars, with typical upper limits between 1 × 10^(−15) and 5 × 10^(−17) Wm^(−2). All 11.2 μm detections from a previous Spitzer survey are confirmed with (tentative) 3.3 μm detections, and both the 8.6 and the 11.2 μm features are detected in all PAH sources. For 6 detections, the spatial extent of the PAH features is confined to scales typically smaller than 0.12−0.34", consistent with the radii of 12−60 AU disks at their distances (typically 150 pc). For 3 additional sources, WL 16, HD 100546, and TY CrA, one or more of the PAH features are more extended than the hot dust continuum of the disk, whereas for Oph IRS 48, the size of the resolved PAH emission is confirmed as smaller than for the large grains. For HD 100546, the 3.3 μm emission is confined to a small radial extent of 12±3 AU, most likely associated with the outer rim of the gap in this disk. Gaps with radii out to 10−30 AU may also affect the observed PAH extent for other sources. For both Herbig Ae and T Tauri stars, the small measured extents of the 8.6 and 11.2 μm features are consistent with larger (≥100 carbon atoms) PAHs.


This research aims to determine the effect of the use of gadgets on student learning outcomes. The type of research used in this research is quantitative. The data collection technique is a questionnaire (questionnaire) and documentation. The data analysis technique used in this study is a simple regression test and t test. The results showed that the results of a simple regression analysis where Y = a+bx = 3.278 + 0.957 X. This means that if there is no increase in the value of the X variable, the value of the Y variable is 3.278. Furthermore, each addition of 1 (one) value of variable X will increase the value of variable Y by 0.957. In addition, based on the results of the hypothesis test, it can be seen that the value of tcount > ttable or 15.591 > 2.0301, then Ho is rejected and Ha is accepted, which means that the regression coefficient has a significant effect. Thus it is proven that the use of gadgets (X) influences student learning outcomes (Y) at SDN 05 Tilango.


The conception on which the affirmative philosophy of G.G. Shpet rests can be called hermeneutic phenomenology. The choice of this term demands explanation. Shpet's basic hermeneutic work, Hermeneutics and Its Problems [Germenevtika i ee problemy], was completed in 1918. At the time hermeneutics was understood usually as the art of grasping the meaning of a text. It is worth noting that this art (skill or technique) was quite specific. It consisted mostly of a set of psychological techniques for "penetrating" into the internal world of the text's author. The techniques were empathy, sympathy, immersion in a historico-cultural world, and imaginative penetration into the author's creative "workshop." Understood in this way, hermeneutics was a psychologically loaded research method. And if it is treated only in that way, the recently coined term "hermeneutic phenomenology" is in respect to content internally contradictory. As I see it, Shpet fully realized what conclusions could follow from this. Nevertheles...


In this paper we prove two fixed point theorems and two Corollary for generalized metric spaces introduced by Dhage .


The invention discloses a version management server authority management method and version management server authority management equipment. The version management server authority management method and the version management server authority management equipment are applied to a distributed system which comprises a version management authority management platform and a plurality of version management servers, wherein authority information and authentication information in the plurality of version management servers and server identification of each version management server are correspondingly stored by the version management authority management platform. When the version management server authority management method is adopted, uniform management of product source code read-write authority of the plurality of version management servers and authentication information of users can be achieved.


A signal conditioning units for vibration measurement in HUMS is proposed in the paper. Due to the frequency of vibrations caused by components in helicopter are different, two steps amplifier and programmable anti-aliasing filter are designed to meet the measurement of different types of helicopter. Vibration signals are converted into measurable electrical signals combing with ICP driver firstly. Then pre-amplifier and programmable gain amplifier is applied to magnify the weak electrical signals. In addition, programmable anti-aliasing filter is utilized to filter the interference of noise. The units were tested using function signal generator and oscilloscope. The experimental results have demonstrated the effectiveness of our proposed method in quantitatively and qualitatively. The method presented in this paper can meet the measurement requirement for different types of helicopter.


Men with symptomatic BPH had statistically significant, durable improvement in lower urinary tract symptoms (LUTS) following an office-based, minimally invasive prostatic urethral lift procedure, results of a pivotal randomized trial showed.


Letter from Josephus Moore to Charles Moore, relating local news and family health. He expresses a desire for the Civil War to come to an unconditional end.


150 samples were requested to investigate the sequence of strokes in the Shuxin component of Chinese characters.3 different sequences were found.Rules to determine their sequences were summarized.


Being a young mother has long-term consequences even during the life of the mother and child in foster care, this hurts both mother and child. The purpose of this review is to look at how childcare in young mothers uses the methodology recommended by Arksey and O'Malley. 11 relevant articles discussed and found key concepts grouped into three main themes namely parenting behavior, parenting stress, and parenting need. Adolescent mothers with higher social support have more knowledge in parenting, parenting attitudes, and self-efficacy in positive parenting, can overcome the temperament of the child, as well as reduce the stress of parenting.


The photographic plate method was used to detect He/sup 3/ particles emitted from helium gas exposed io bremsstrahlung of maximum energy 70 Mev. The He/sup 4/( gamma ,n)He/sup 3/ cross section is found to vary between values of 10.63 plus or minus 0.10) mb at 40 Mev and (0.25 plus or minus 0.04) mb at 60 Mev. the integrated cross section being 7.5 Mev mb between these limits. The angular distribution of the He/sup 3/ parti-cles in the C.M. system has a peak in the forward direction and may be described by the expression f( sigma ) = B sin/ sup 2/ theta /(1 + C cos theta ) with C approximately equal to 0.5. (auth)


Through analysing the shortcomings of the traditional methods of eliminating residual stress, and aimed at the mechanism of eliminating residual stress, put forward the method of eliminating aluminium alloy welding residual stress by ultrasonic. Explained the superiority of using ultrasonic to eliminate aluminium alloy welding residual stress by the comparison with heat treatment and vibration processing that are the most commonly used methods in practical engineering.


Community colleges are the important carriers in the construction of the learning society and lifelong educational system. According to the requirements of the organizations and residents in an estate a community college is a community educational base including both academic education and training education. 


Our previous studies have discussed an effective improved artificial potential field based simultaneous forward search method (an Improved APF-based SIFORS method) in known and static environment. This paper presents the proposed Improved APF-based SIFORS method for autonomous mobile robot path planning in an environment including partially known or unknown, and dynamic complex environments. It can program a valid, feasible and shorter solution from the robot location to the target position. We redefine repulsive potential field and improve the wall-following method to solve intrinsic fatal problems of previous methods, and to address local minima and oscillation problems of the proposed method when a robot moves in a partially or entirely unknown environment. Using the latest five steps to assess the moving tendency of the robot, and combine the proposed wall-following method to an assistant robot to move out of local minima and oscillatory movements. To demonstrate the applications of our proposed method, we simulated paths planning for a local sensing range of a robot, a dynamic target, and moving obstacles in complex environments.


Human Remains from Maya Territory. -A few broken calvaria, a few fragments of long bones, and a few sets of teeth are all the skeletal remains that we possess of the ancient inhabitants of the Maya territory. In the admirable report upon the ruins of Copan, by Maudsley, we read that "traces of bones were found," "a few small fragments of human bones were found," etc. The more recent explorations at the same ruin by the expeditions from the Peabody Museum have resulted in the discovery of " fragments " and "6 filed teeth." The few crania which, it might be inferred from the field notes, were well preserved and which are now in the Peabody Museum are in too fragmentary a condition to be available for study. In his account of the ruins of Xkichmook,1 Mr. Edward Thompson describes the structure and architectural remains of an interesting group of ruins. We may readily believe that the "Palace," which he pictures in word, photograph, and plan, is " a most imposing structure," as its walls stand 64 feet high and are raised 8o feet above the surrounding level. Notwithstanding the probably dense population, as indicated by the extent of the ruins which formerly occupied the region, very few human remains were found. "Badly decayed human bones and teeth," "fragments of human bones much decayed," etc., is the record of the explorations among the burial chambers. In a pleasantly written narrative2 Mr. Gordon gives an account of the Honduras of to-day and of the vast quantities of potsherds and other artifacts that exist along the Uloa River. Whether or not they were manufactured by a race distinct from the Mayas, as suggested by Mr. Gordon and Professor Putnam in his editorial note, they indicate the presence of an extensive population in that valley in former times. However, the disappointing statement again appears, "The human remains . . . consist of crumbling fragments of bone . . . 1 Thompson, Edward. Ruins of Xkichmook. Field Columbian Museum, Anthropological Series, vol. ii, No. 3.


Polish revolution – far reaching changes to Polish competition law. Part 1 – fines for individuals* On 10 June 2014, the Polish Parliament adopted a significant set of amendments to the Polish…


The freeboard height of the ship is a critical parameter that mirrors the ship's load capacity and safety performance. However, research on the height of the ship is less explored. This letter derives imaging differences between the top and bottom of the ship's freeboard based on SAR imaging geometry and then establishes a ship-sea coupling scattering path model. Relying on the proposed model and the polarimetric synthetic aperture radar's (PolSAR) capability to differentiate various scattering mechanisms, a method for retrieving the freeboard height of ships is proposed. This method primarily utilizes the total backscattering power SPAN and double-bounce scattering component (DBL) features of single-pass PolSAR data acquired with a single antenna. Finally, the proposed method is verified by the in situ data and tested on different types of ships, such as cargo ships and bulk carriers, and the absolute relative error (ARE) of the retrieval results is less than 6.1%.


In order to analyze the influence of exceeding the initial room temperature criterion on a missile motor under conditions of high and low temperatures,three-dimensional solid for every part of the first stage motor was simplified and modeled by the CFD method.After considering heat conduction,convection and radiation,the stationary simulation calculation was conducted by the fluid-solid coupled heat transfer method to obtain the temperature distribution at different temperatures in severe field environment and theoretical basis used for adjusting the initial room temperature criterion.Through simulating the model described in Reference [2],it could be determined that the results of the simulation are in accordance with that of the experimental data.Using the CFD method and the fluid-solid coupled method can provide both reference and basis for adjusting the temperature of missile motor propellant.


Two conceptual approaches are used to evaluate symptom clusters: "clustering" symptoms (ie, variable-centered analytic approach) and "clustering" patients (ie, person-centered analytic approach). However, these methods are not used consistently and conceptual clarity is needed. Given the emergence of novel methods to evaluate symptom clusters, a review of the conceptual basis for older and newer analytic methods is warranted. Therefore, this article will review the conceptual basis for symptom cluster research; compare and contrast the conceptual basis for using variable-centered versus patient-centered analytic approaches in symptom cluster research; review their strengths and weaknesses; and compare their applications in symptom cluster research.


A case of acute myocardial infarction and signs of ischemic heart disease as the only manifestation of the myeloproliferative disorder essential thrombocytosis in a 17 year old male is presented.


Background:  Cell Block (CB)  procedures  have  now  become  an  established  part  of cytological  diagnostics  because  of  its  pivotal  role  in  diagnosis  and  ancillary  studies. Hence  the  present  study  was  undertaken  to  emphasize  the  role  of  CB  technique  over Conventional Smear (CS)  in  serous  effusions  and  to  compare  the  Plasma-Thrombin (PT) block  to  Formalin  Method  block (FM)  in  assessment  of  morphological  preservation  and  cellularity. Aim: To  obtain  simple , cost  effective  and  ideal  CB  preparation  where  in  maximal number  of  cells  are  displayed  within  a  small  area Methods:  The sample  was  divided  into  three  Parts(A,B,C). After centrifugation  of  all three  parts  of  sample  at  3000rpm  for  15min – Part A  sediment  was  used  to  prepare two  CS  for  Papanicolaou (PAP)  and  May Grunwald Giemsa(MGG)  stains.  Part B sediment  was  subjected  for 1hr  and  24hr  fixation  in  1:1 solution of  5ml  ethylalcohol and  10%  formalin. To  the  Part C  sediment  2drops  of  finger  prick  plain  blood  was added,  mixed  well  and   allowed  to  clot. The  sediment  of  Part B  and  the  clot  of  Part C were  then  processed  for  paraffin  embedding. Result: 110  fresh  effusion  samples  were  evaluated  for  cellularity retention  of architectural  patterns  and  volume  of  background.  FM  block's  were  inconclusive  in  12 cases  due  to  low  cellularity. PT  block's  were  all  evaluable  with  best  preservation  of architecture  and  pale  background. Conclusion: The CB  technique  revealed  better  architectural  patterns  and  increased  the sensitivity of  cytodiagnosis. PT block's  had  sufficient  to  abundant  cellularity  with evenly distributed  cells  in  small  area.  PT preparation   is  simple  and  cost  effective.  DOI: 10.21276/APALM.1432


JUST CULTURE: WHEN, WHY AND WHAT

• When: response of an organization towards individuals or groups who were involved in a safety event, especially of high severity

• Why: investigation whether staff demonstrated offending behaviour or intentional violation of rules

• What: • unintentional errors and mistakes are tolerated by management • deliberate breaches of rules might incur punitive action


To find a good way to teach, theories and experiments need to be progressed in same class in the anatomy of the domestic animal. The result shows that it is a good way for teaching to make up the shortcomings caused by the shortage of teaching time, and that it is easy for students to study.


We have comparatively evaluated the proliferative response of CTL induced in metastatic melanoma patients upon immunization against Melan‐A/MART‐127–35 tumor associated antigen (TAA) to IL‐2, IL‐7 or IL‐15 cytokines, sharing a receptor common γ‐chain (cγ‐c cytokines). Twenty‐eight CTL clones were generated from CD8+ T cells obtained from 3 patients during the contraction phase of immune response following a successful vaccine mediated expansion of specific effectors. All clones were able to kill tumor cell lines expressing HLA‐A0201 and Melan‐A/MART‐1, and displayed phenotypic characteristics of effector/memory (CD45RA−/CCR7−) or CD45RA+/CCR7− effector cells in intermediate to late developmental stage (CD28−/CD276±) CTL. Proliferative responses could be elicited or enhanced by IL‐2 and IL‐15, but not IL‐7, in the absence or in the presence of T‐cell receptor (TCR) triggering, respectively. Accordingly, only IL‐2 and IL‐15 were able to promote the survival of the CTL clones under investigation. While all clones expressed high amounts of receptor cγ‐c (CD132), lower, but detectable, expression of IL‐7 receptor alpha chain was also observed. CD8+ cells from one of the patients treated were obtained 6 months after the last vaccine boost and were cultured in the presence of Melan‐A/MART‐127–35 and each of the 3 cytokines under investigation. Consistent with data from CTL clones, expansion of Melan‐A/MART‐127–35 tetramer positive cells was only observed in the presence of IL‐2 or IL‐15 but not IL‐7. Instead, when CD8+ cells from the same patient were sampled shortly (14 days) after an additional vaccination only IL‐2 was able to promote the expansion of Melan‐A/MART‐127–35 tetramer positive cells. Taken together these data suggest a selective responsiveness of TAA‐specific CTL to different cγ‐c cytokines. © 2005 Wiley‐Liss, Inc.


Most of the current studies on non-uniform earthquake response of long-span bridge structure are focused on deterministic analysis. In the paper, strong motion records with long-period information are firstly selected, whose response spectrum is taken as the target spectrum. Then the power spectrum density function is achieved with an iteration method. Afterwards, the relevant parameters are resolved by fitting the Clough-Penzien random vibration model. Finally, the non-uniform stochastic earthquake response of some long-span cable-stayed bridge is analyzed based on an improved pseudo-excitation of the direct displacement method with high efficiency. The results show that different apparent wave velocities have significant influences on the displacement response and the internal forces response of long-span bridge structure.


Future sub-arcsecond resolution, large-effective area x-ray telescopes that use segmented grazing-incidence mirrors will require a bonding and alignment method that simultaneously: 1) achieves the accuracy needed for scientific observations, 2) possesses the strength needed to survive the ride to space, and 3) has high throughput to bond and align tens of thousands of components in a couple years. Current bonding and alignment processes are either over-constrained to achieve high strength with modest accuracy, or quasi-kinematic to achieve high accuracy but with lower strength. We propose an over-constrained mounting approach where spacers separating mirrors have set-and-forget adjustable height. This approach may provide the advantages of high strength and high accuracy simultaneously, while loosening initial assembly tolerances to improve process throughput. In our proposed process, glass spacers are fabricated with μm-accuracy using ultrashort pulsed laser-assisted chemical etching and Bessel beam optics. Their length is adjusted after assembly and bonding, using the same laser and optics. We show examples of our fabricated spacers assembled into stacks of mirrors and bonded using epoxy with spacer beads. In a separate experiment, we show that the length of spacers can be quickly and stably adjusted with μm-range and with nm-resolution as required for aligning x-ray mirrors. This bonding and alignment process may help solve a longstanding and critical challenge for future sub-arcsecond resolution large-effective area x-ray telescopes.


The third-party liability insurance of motor vehicles is a kind of law system, which can effectively protect the benefit of the third party who is injured in the accidents. After the enactment and implement of The Road Traffic Security Law, the legislation of the third-party liability insurance of motor vehicles in our country hasn't accommodated to protect the benefit of the third party who is injured in the accidents. Referring to the foreign advanced experience, this passage puts forward the perfection of the legislative measures of the third-party liability insurance of motor vehicles in our country, which can meet the requirements of domestic and abroad situation, and also improve the effective using of the liability insurance of motor vehicles in our country.


This paper outlines the World Bank Group's approach to how results-based financing (RBF) can resolve some of the forthcoming constraints faced by client countries to achieving the education Sustainable Development Goal (Goal 4). In sum, the WBG approach uses RBF as an instrument to strengthen education systems, by aligning and incentivizing actors around a set of system results. This stands in contrast to other approaches whereby RBF is first and foremost considered as a way to increase value-for-money, or more generally as a tool for "smarter aid". The RBF agenda in education takes a wide lens, consisting of knowledge activities, convening services, and financing instruments such as the Program-for-Results lending instrument, and other financial modalities that reward the achievement of independently verified results. The World Bank Group has committed to doubling its current education portfolio of RBF operations to US $5 billion by 2020.


The determinants of international currency received a lot of attention since the great recession. Classic literature focused on economy size and openness, but that couldn't explain why RMB remains largely national, while China is already leading in international trade. In this paper, I verified the importance of financial development for currency internationalization using SWIFT trade finance data. Then I built a two-country monetary search model where trade takes time, and lack of committment makes exporter and importer rely on bank-intermediated finance. The agent's currency choice is related with terms of trade, monetary policy, and financial efficiency. Optimal monetary policy differs according to currency regime. Related topic such as size effect and global imbalance is also discussed.


Hydroxya- patite (HA) is a calcium phosphate containing hydroxyde with chemical formula Ca10 (P04) 6 (OH) 2. HA and trikalsium phosphate [Ca (PO4) 2] can be used as bone im- plant material because it is 3 bionert, biocompatible bond- ing agent and bioactive. In this research was conducted the process of making hydroxyapatite, which is the material used is a bone of a cow in the cortical or colloquially known as the compact bone. The rst cortical bone powder with crushed/created using the engine revolving speed milling fress 1200 rpm and the speed of motion of 7-8 mm/min, and then on the sintering of 900 c so as to be materials hydroxyapatite (HA) and then ltered with a mesh size of 200. Material HA then mixed a adhesive colophony (pine resin) as the ratio of 10gr, use 1: 1, 1, 2, 1: 3 then entered into a new dies and in kompaksi by using hydraulic load capacity of 3, 5, 20ton. From the results of observations made, hydroxyapatite in General is strukturmikro HA and colophony. From the test results to measure the particle HA of all variations of the average ratio of around 3.2 m in diameter for the distribution of its spread from variation 1: 1, 1, 2, 1: 3, out of all the hydraulic load capacity used i.e. average 3 7,5


This literctture review examines the industrial effluents chemical in rivers
and health implications on c"'ocodiles in South Africa. The main purpose of the
study is to examine rivers and the discharge of industrial effluents on the health
implications q{ crocodile in South Africa River and determine the effect and
causes of industrial effluent on rivers in South-Africa. This literature review was
carried out on Crocodiles Rivers in South Africa to assess the extent of chemical
pollution in a receiving river as affected by industrial effluents. Both the effluents
and the water as the selected rivers analyzed for pH, dissolved oxygen, nitrate,
alkalinity, hardness, chloride and phosphate in the dry and rainy seasons. The
results showed that the effluents were acidic in both the dry season (range: 4.2 ±
0.02--6.5 ± 0.02) and in the rainy season (range: 4.2 ± 0.05 ~ 5.6 ± O.O}). While
the levels ql dissolved oxygen, biological oxygen demand, electrical conductivity,
suspended solids, alkalinity and chloride were relatively high in the dry and rainy
seasons, the concentration of phosphate and nitrate were low in both seasons. The
water upstream was neutral (average pH, 7.40 ± 0.04) with high dissolved oxygen
but low in the levels of the other parameters in both seasons. The water after the
~fJluent receiving points was acidic and the ,levels of the other parameters were
high, especially downstream which has significant e.ffect on the crocodile living in
the river. The results suggested that the water in the river was polluted and not
good for human consumption. It is therefore recommended that the careless
disposal of the wastes should be discouraged and although the values in some
cases were lower than the allowable limits, the continued discharge of the
effluents in the river may result in severe accumulation of the contaminants and,
unless the authorities implement the laws governing the disposal of wastes, this
may affect the lives of the people.


This paper presents a new state space model predictive control scheme for linear systems with partial actuator faults. To consider dealing with the uncertainties caused by actuator faults, the process is first treated into a nonminimal representation using state space transformation. Then the subsequent design of model predictive control is introduced to yield improved closed-loop control performance under unknown disturbances and actuator faults. The advantages of the proposed method over existing methods lie in the fact that the proposed control method can regulate both the process output/input changes in the design, which cannot be achieved by traditional state space model predictive control. For performance comparison, a traditional model predictive fault-tolerant control is also designed. Simulations are given to illustrate the feasibility and effectiveness of the proposed scheme.


The paper presents the reasons for the need to diff er the notions of: diagnosis likelihood and diagnos is rightness at making operating decisions. The formula of proba bility for formulating the right diagnosis, as the measure of diagnosis likelihood, has been herein derived. For deriving this formula the theory of semi-Markov pr ocesses and the Bayes' formula of conditional probability have been applied. Other probabilistic measures of diagnosis likelihood have also been provided. These measures have been r eferred to technical state of such important system as e.g. main engines of sea-going ships. However, they can be us eful for determining the technical state of other transport means.


I reviewed 12 acoustic and 5 archival tagging studies on salmonids that have been conducted in Japan since the 1970's. Acoustic tags have been used from the mid 1970's for salmonid research and archival tags were introduced to salmonid research in the 1990's. In the 1970's and 1980's Japanese acoustic tagging systems were used in Japan but from the 1980's the VEMCO system became increasingly popular. Eight of 12 acoustic tagging studies were conducted in coastal waters, three studies were done in offshore waters and high seas, and one in a lake. In one of five archival tag studies, fish were released from offshore waters, but other works were conducted in coastal waters and rivers. Chum salmon were used for most of Japanese studies and recently masu salmon were also studied. The purposes of the research using smart tags have been to investigate fish behavior in relation to fishing gear and to investigate salmon orientation and homing mechanisms. The principal motivation, especially for the early studies, was to learn how salmon move at sea. To facilitate communication with North American scientists, I put together a list of Japanese scientists using smart tags for studying salmonids.


The effects of the etching gas chemistry, the RF bias frequency and the ECR position in pattern-dependent charging were studied using an ECR plasma etch tool. Lowering the RF bias frequency and/or employing a gas chemistry containing an element with small mass such as hydrogen reduced electron shading damage and notching. Notching was suppressed by increasing the distance between the ECR point and the wafer. Furthermore, it is effective to employ an etching gas that contains elements of small atomic weight for reduction of electron shading damage by using continuous wave (CW) high-density plasmas.


Introduction. In a five-year follow-up comparative study we will present the outcomes after implantation of three cementless short femoral stems : MINIHIP (Corin), SMF (Smith&Nephew) and FURLONG EVOLUTION (jRi). Material and methods. We have analysed the data of 180 patients (88 females, 92 males), in three groups of 60 patients, each group using a different implant. Evaluation of the radiographic outcomes was assessed for: subsidence, angular stem migration, stress shielding, malalignment and periprosthetic fractures. Results and Conclusion. SMF stem is less stable in comparison to MINIMHIP and EVOLUTION, differences are statistically significant, in vertical (subsidence P=0,011) and in angular migration (frontal plane-varus P=0,008). We didn't find statistically significant differences comparing MINIMHIP and EVOLUTION stems in vertical and angular migration. Revision hip arthroplasty was necessary only after implantation of the SMF stem 6 cases. All three stems can be implanted using minimally invasive direct anterior approach /DAA/. All three stems can be replaced using a conventional hip stem if revision hip arthroplasty is necessary.


The purpose of the work is to study the process of phenol sorption by wheat processing wastes. Much attention is paid to environmental protection in the modern world, especially water resources, since clean water is necessary for human existence. Modern enterprises of various industries and agriculture are increasingly introducing waste-free technologies or highly efficient wastewater treatment methods into production. One of the simple in hardware design and implementation, but very effective, is the sorption method. The use of production waste as sorbents is very promising, because. allows, in addition to the environmental problem, to solve the issue of disposal or recycling of production waste.Methods.When studying the composition of chaff wheat, the following methods were used: determination of ash and moisture by weight; cellulose nitrogen-alcohol, pentosans spectrophotometric with orsin, lignin Komarov's method. Sorption of phenol by wheat processing waste was carried out by the method of single-stage static sorption at a temperature of 250C.Identification of the nature of phenol sorption by non-food waste from grain processing was carried out using the IR spectroscopy method. Using the Nicoleti S50 FT-IR IR-Fourier spectrometer without molding tablets in the range of 4000 400 cm-1, the IR spectra of phenol, wheat chaff and wheat chaff after phenol sorption were taken.Results. Analysis of the chemical composition of wheat waste (chaff) showed that the main components are cellulose (34.8%), pentazans (19.7%), lignin (23.1%).When analyzing the obtained IR spectra, it was found that in the IR spectrum of non-food waste from wheat processing after phenol sorption, a peak appears at 2323.37 cm-1, which is associated with the formation of a bond between the mobile hydrogen atom of the benzyl alcohol group of lignin with the hydroxyl group of phenol .Conclusion. IR-spectroscopic study of the process of sorption of phenol by non-food waste from wheat processing (chaff) showed that during the sorption of phenol, a chemical bond arises between the sorbent and the sorbate, which manifests itself in the IR spectrum as a new absorption band.


In this paper, the random balanced growth factor to forward-lag-type and mixed-lag-type input–output (IO) models is considered. The instability of IO and capital matrices is taken into account by stochastic methods. Exact and approximate characteris-tics of stochastic solutions are given.


7‐Dehydrocholesterol reductase (DHCR7) catalyzes the final step in cholesterol synthesis by reducing the 7–8 double bond of 7‐dehydrocholesterol. In skin cells 7‐dehydrocholesterol also can be converted to cholecalciferol (vitamin D3) by ultraviolet radiation, providing a second pathway for 7‐dehydrocholesterol metabolism in these cells. We hypothesized that keratinocytes might regulate cholecalciferol levels by modulating the activity of DHCR7, a hypothesis supported by evidence that DHCR7 is a phosphoprotein, and is activated by the addition of ATP to liver microsomes.


The load-sensing system is established and the energy-saving principle of load-sensing system is introduced.Simulation model is established by using AMESim software.Load pressure changes are researched by simulation to analyze the impact on the output flow of pump when the system is in the state of constant flow and load-sensing valve spool area are researched by simulation to analyze the impact on the dynamic characteristics of the system.Simulation results show that when the system is in the state of constant flow,load pressure changes have no impact on the output flow of pump and load-sensing valve spool area has an important impact on stability of the system.


BackgroundHighly active antiretroviral therapy (HAART) including two nucleoside analogues and a potent protease inhibitor is standard of care initial therapy for HIV-infected adults. The best-tolerated and most potent initial HAART regimen is unknown and was investigated in this study. MethodsOne hundred and nine HIV-infected adults with no prior antiretroviral therapy, and CD4 lymphocyte counts < 500 × 106 cells/l or plasma HIV RNA > 30 000 copies/ml were randomized to zidovudine–lamivudine–indinavir (ZDV–3TC–IDV), stavudine–lamivudine–indinavir (d4T–3TC–IDV) or stavudine–didanosine–indinavir (d4T–ddI–IDV) for 52 weeks. The primary endpoints were plasma HIV RNA and drug-related adverse events. Other assessments were overall safety, adherence and adverse events, CD4 lymphocyte counts, cutaneous delayed type hypersensitivity (DTH) responses and quality of life (Euroqol). ResultsOnly 58% patients had HIV RNA < 50 copies/ml plasma at 12 months, with no significant difference between the three regimes (P  = 0.34). Drug-related adverse events sufficiently severe to warrant drug discontinuation were less common (P  = 0.06) in patients receiving d4T–3TC–IDV (18%) than in those receiving ZDV–3TC–IDV (34%) or d4T–ddI–IDV (41%). The percentages of patients who remained on their assigned therapy with plasma HIV RNA < 50 copies/ml at 52 weeks were 60% with d4T–3TC–IDV, 53% with ZDV–3TC–IDV and 35% with d4T–ddI–IDV. Virological failure at 52 weeks was more likely in those whose adherence was estimated to be < 100% in the first 4 weeks of therapy (P  = 0.02), but not in those who developed grade 3 or 4 drug-related adverse events. At 52 weeks, the mean CD4 lymphocyte count increase was 200 × 106 cells/l with only 7% of patients having counts lower than at baseline; DTH responses improved but remained clinically impaired in most patients. Quality of life improved significantly in all groups. ConclusionsInitial HAART regimens including IDV failed to suppress plasma HIV RNA to < 50 copies/ml in > 40% patients after only 12 months of therapy although there was significant overall improvement immunologically and in quality of life. The type of dual nucleoside combination used was less important in predicting virological failure than was imperfect adherence early in therapy. Consideration should be given to modifying a HAART regimen relatively early in non-adherent patients.


A method of establishing helical gear using Pro/ENGINEER is introduced in this paper. Using the tools of the program and relations,the parameterized design of helical gear is realized. The gear can be created with the assigned gear parameters by man-machine interactive way. A great deal of repeated design work will be reduced.


Nowadays, negotiation capability isthe baseskills forus.Effective negotiation canmake cooperation moresuccessful, andjobmoreefficiently. Negotiations donotjusthappened between firms, but alsooccurwithin acompany. Thisstudy wasmainly focus onnegotiations indaily life. Experiments were conducted to explore maininfluential factors of negotiation outcomes. Thisstudy wasmainly focus on price andinformation inmanynegotiation influential factors. Thepurpose ofthis study wastoimprove the efficiency inourdaily corporation management, andalso increase thevalidity andrationality ofenterprise resource configuration. Authors gotthedatafromexperiments, andthenanalyzed itbyusing linear regression method andSPSSsoftware. Thediscussion ofexperimental result provided veryuseful negotiation viewpoints and skills fromthreeaspects: priceinformation and relationship.


Resorcinol-formaldehyde/ammonium perchlorate(RF/AP) nanocomposite with different AP contents were prepared by the sol-gel and freeze drying method and characterized by FTIR,XRD,SEM,BET and TG/DSC methods.Results show that the sol-gel process can't destroy the crystal structure of AP.When AP content is lower than 60%,with AP content increasing the surface area of RF/AP nanocomposite decreases from 11.23m2·g-1 to 0.29m2·g-1,the exothermic peak temperature and the heat output of the composite increases.In comparison with pure AP,the exothermic peak temperature of RF/AP nancomposite shifts about 100℃ downwards.When the AP content is up to 60%,the heat output of the composite increases to 2 854.9J/g.


This paper aims to explore and evaluate aerial imagery and deep learning technology in pavement condition evaluation. A convolutional neural network (CNN) model, named PCIer, was designed to process aerial images and produce pavement condition index (PCI) estimations, which are classified into four scales of Good (PCI ≥ 70), Fair (50 ≤ PCI < 70), Poor (25 ≤ PCI < 50), and Very Poor (PCI < 25). In the experiment, the PCI datasets were retrieved from the published pavement condition report by the City of Sacramento, CA. Following the retrieved datasets, the authors also collected the corresponding aerial image datasets containing 100 images for each PCI grade from Google Earth. An 80% proportion of datasets were used for PCIer model training, and the remaining were used for testing. Comparisons showed using a 128-channel heatmap layer in the proposed PCIer model and saving the PCIer model with the best validation accuracy would yield the best performance, with a testing accuracy of 0.97, and a weighted average precision, recall, and F1-score of 0.98, 0.97, and 0.97, respectively. Moreover, future research recommendations are provided in the discussion for improving the effectiveness of pavement evaluation via aerial imagery and deep learning.


In this bachelor thesis I am dealing with the design of women's luxury rubber boots in cooperation with the Novesta company. My goal is the creating of graceful boots for women aged 20 to 40 years old. The first part, theoretical one deals with a history and a manufacturing of rubber boots and it also provides a short overview of other competitive brands. The second part, practical one describes the formation of my designs from the initial inspiration through sketches to the production of final collection.


The warship equipment maintenance support system is a complex system, which has uncertainty. Aimed at uncertain support scheme, the equipment maintenance support simulation experiment (EMSSE) is a method based on exploratory analysis (EA) and simulation. According to the characters of EA and the demand of EMSSE planning, an experiment framework (EF) based on EMSSE was put forward a experiment framework (EF) which makes the problem solved more flexibly because of being independent of the simulation model,, and the content was analyzed in detail. Finally, an example of warship maintenance support is introduced to explain application of EF and validate it feasible.


The spectrum of the Hermitian Hamiltonian H = p2 + V(x) is real and discrete if the potential V(x) → ∞ as x → ±∞. However, if V(x) is complex and -symmetric, it is conjectured that, except in rare special cases, V(x) must be analytic in order to have a real spectrum. This conjecture is demonstrated by using the potential V(x) = (ix)a|x|b, where a, b are real.


A Nuclear Power Plant has very sophisticated piping systems operating in a very aggressive erosion and corrosion environment with turbulent flow, high temperature and pressure. These adverse operating environments make a piping system very vulnerable to accelerated wear and degradation. [1, 2] But there is no practical way to monitor the wear and degradation during operation. In this study, we suggested and investigated the monitoring methodology for the wear and degradation of the piping system by using the accelerometer. The suggested methodology was based on the changes of the vibration mode due to the corrosion on the pipe. [3] The accelerometer could be used to monitor the vibration of the system. For confirming the change of the characteristics of the vibration signals due to the corrosion, we simulated the vibration mode of piping system with artificially corroded elbow. For simulating the corroded piping system, we made three artificially corroded elbows. For analyzing the characteristics of the vibration signals, we used the power spectrum density with auto-regressive model. From simulation and analysis, we had a signature for wear and degradation on the piping system.


A power quality analysis method based on electromechanical-electromagnetic hybrid simulation is proposed. The hybrid simulation for power quality analysis can not only enhance the simulation accuracy, and can realize power quality simulation of large scale power system. Then power quality simulation and assessment system is developed based on ADPSS. The system provides plenty of power quality models and achieves power quality simulation based on electromechanical-electromagnetic hybrid simulation. It will provide guidance and reference for power quality study. The hybrid simulation model of an actual large scale power system is built and voltage sag problems caused by short circuit tests are simulated based on the developed system. Simulation result shows the practicality and effectiveness of power quality simulation and assessment system.


2018/09/ 4 Abstract Introduction: Nowadays, academic Spin off have been created as one of the entrepreneur phenomena in countries and study the factors affecting them is one of the most important priorities of universities. The purpose of this study was to compare the importance of effective factors on formation and development of these companies in Ministries of Science and Health. Methods: This was a descriptive field study. Statistical population Were the Graduate students of Shahid Beheshti Universities, Tehran, Allameh Tabatabaei and Kharazmi, and third and fourth year students of medical faculties, paramedical, health and medical technologies of the universities of Shahid Beheshti, Tehran and Iran in academic year 2017-2018. With the Cochran formula, the sample size was 331. The research instrument was a researcher-made questionnaire. Validity and reliability of this questionnaire were confirmed using factor analysis.Data were analyzed by independent t-test through SPSS. Results: In the phase of formation of academic spin off, the average importance of different factors were as follow: individual factors (t=-2.795), educational factors (t=-2.061), background factors (t=7.927), and institutional factors (t= 4.409). In the development phase, the average importance of organizational factors (t=2.367) was different between two groups of students. There was no significant difference in other factors these companies and consider special criteria for evaluating and improving


The aim of the study was to improve yield, quality and nutritional value of broccoli head with different dose and application methods of zinc and boron and also decide the best possible treatment combination. The experiment was conducted in Palli sikhsha bhavana, agriculture farm, Visva Bharati (Sriniketan) during rabi seasons of 2018-19 and 2019-20 from October to January. It was laid out in a Factorial Randomized Block Design consisting of 9 treatments of zinc and boron combination with different doses and application method replicated thrice. Three treatments of Zinc viz. Z0 (no zinc), Zf (foliar application @0.5% ZnSO4), Zs (soil application @25 kg/ha ZnSO4) and three treatments of Boron viz. B0 (no boron), Bf (foliar application @0.5% borax), Bs (soil application @2 kg/ha borax) randomized among themselves The crop was planted (spacing of 50 cm X 40 cm), fertilized (N: P2O5: K2O::150:100:100) and irrigated as per recommended practices. Five plants from each plot were randomly selected and tagged for data collection. Treatment (T8) combined application of boron soil @2 kg/ha and zinc as foliar @0.5% was found superior for total yield (28.9 ton/ha) and head weight per plot (695.4 gms). Vitamin C and total chlorophyll of broccoli head significantly improved with combined application of zinc in soil @25 kg/ha and boron as foliar @0.5% with highest value of 1117.5mg/g and 0.77mg/g respectively. Highest Total sugar and reducing content was recorded for combined application of boron in soil @2 kg/ha as well as foliar @0.5% with value of 1.7% and 1.62%. Crude protein content in broccoli head was significantly improved with zinc foliar application @0.5% with a value of 14.34%. Zinc concentration and zinc uptake by broccoli head was significantly increased by zinc foliar application @0.5% recording highest value of 0.041% and 6.67 kg/ha whereas boron concentration and uptake was improved by combined application of boron soil @2 kg/ha and zinc as foliar @0.5% with a value of 0.0049% and 2.26 kg/ha respectively. The combined application of boron in soil @2 kg/ha and zinc as foliar @0.5% would be the best treatment to impact on yield, quality and nutritional values of broccoli head in red and lateritic soils of Birbhum district.


Background: Von Hippel-Lindau (VHL) disease is an autosomal dominant familial cancer syndrome that occurs as a consequence of an inactivation of the VHL gene. Point mutations in VHL are a major cause for VHL disease, and fragment deletions contribute to ~30% of VHL patients. Array Comparative Genomic Hybridization (Array-CGH) is a powerful tool for the identification of genomic deletions, and often reveals unexpected information as a non-targeted method. Method: We extracted the DNA from the patients' blood andscreened for point mutations in VHL by PCR and large deletions by Array Comparative Genomic Hybridization (Array-CGH). Real-time quantitative PCR was used to confirm the deletion of VHL gene and expression of VHL in tumor tissue. Results: We present a family case of VHL syndrome, showing hemangioblastomas in the central nervous system and retina, multiple pancreatic cysts and clear-cell renal cell carcinoma. After excluding point mutations in VHL gene exons and conjunctive regions, we identified a ~9 kb deletion of chromosome 3p25.3 with Array-CGH analysis. Real-time PCR confirmed a heterozygous deletion in exon 3 of the VHL gene. Additional 90 DNA deletions were detected ranging from 5 kb to 160 kb in size. Moreover, 70.3% of the breakpoints were located in Alu elements. Conclusions: This study confirmed that DNA deletions contribute to familial VHL disease. It also highlights that coding deletions appear to be more frequent than expected, and that Alu-mediated recombination is the major mechanism.


The objective was to determine if serum leptin expresses a circadian rhythm in goats, and the effect of body mass index (BMI) and season of the year on such expression. Eight mature, ovariectomized, female goats with s.c. sylastic implants containing 17I²-estradiol were maintained in a high (HBMI, n=4) or low (LBMI, n=4) BMI during the breeding (BS-december, n=8) and transition into anestrous (TS-february, n=8) seasons. Blood samples were obtained every hour throughout a 48 h period and serum leptin determined (Linco Res. Inc.). Results were analyzed by COSINOR program (fit of data to a cosine curve) obtaining the MESOR (mean leptin concentration), AMPLITUDE (half difference between   highest and lowest leptin concentration) and ACROPHASE (time of highest leptin concentration). Frequency of occurrence of a circadian rhythm was analyzed by Fisher's Exact test. A leptin circadian rhythm was evident (P 0.05) in AMPLITUDE for any effect or their interaction. Evidence of a serum leptin circadian rhythm in female goats, with a diurnal increase in serum leptin was found and reported for the first time. Moreover, an effect of interaction between BMI and season in the expression of such rhythm was observed. Studies involving serum leptin in goats should take into account its circadian variation; otherwise under- or over-estimations might occur.


The Virtual Reality Modeling Language (VRML) is a standard to describe virtual scenes.VRML 2.0 standard is highly focused on as published.As a matter of fact,most applications perform perfectly in the construction of static scenes and the use of its own events and routes,but what has not been paid enough attention to is further interactive functions on how to achieve required datas, and how to set explicit parameters.This paper researches the way that VRML and java combine and analyses their communication protocal,by which,we have realized how to get coordinates of prescribed points and information about appointed site,as well as how to control virtual scenes interactively. Based on the communication of VRML and java,we can establish an interactive 3D multimedia world in Internet,and we have constructed the virtual reality system of our university.


Synodontis ngouniensis, new species, is described. It is endemic to the Ngounie River (Ogooue River basin) and the Nyanga River basin. It is distinguished from all other Synodontis species of the Lower Guinea Ichthyofaunal Province by: a dorsal spine with a smooth anterior margin except for the presence of 1-4 feeble serrations on the distal part; a maxillary barbel witha smooth membrane, which is proximally at least as broad as the barbel thread and situated on the posterior basal two third of the barbel; 12-19 mandibular teeth; 10-13 gill rakers on the ceratobranchial of the first branchial arch; a triangular humeral process, and a striking colour pattern of black overall background colour with irregular whitish lines and dots.


A a non-contiguous U.S. state, Hawai'i depends agricultural shipments to the U.S. mainland than their exclusively on sea and air transportation as a foreign competitors. means of distributing agricultural products to the U.S. mainland market.A2003 case study by the United States Method and data Department of Agriculture (USDA) on the geographical Matson Navigation Company, the largest shipping comdisadvantages of Hawai'i's farmers and ranchers reports pany in Hawai'i, handles most of Hawai'i's agricultural several deficiencies of Hawai'i port infrastructure,(1) shipments to the U.S. mainland.(2) Matson publishes including inadequate space at seaports for both pasdetailed freight rates, which can be used to measure senger and freight traffic, lack of shaded or refrigerated Hawai'i's ocean freight costs. For air cargos, such as staging areas, and insufficient length of Neighbor Island cut flowers, airlines in Hawai'i usually determine freight runways. In addition, the study suggests that Hawai'i's rates according to the nature of the cargos (perishables or high labor costs and small cargo scale tend to unfavornon-perishables) or by using more specific Commodity ably affect its freight costs. Codes. Information about Hawai'i's air freight rates for The USDA study also finds that lack of easily accesagricultural shipments can be obtained directly from sible information on freight costs has caused "constant experts in the industry. confusion and frustration of Hawaii agricultural shipData constraints make it difficult to implement this pers" over the hypothesis that they "always pay more direct approach to foreign countries exporting to the U.S. to ship their cargo to the mainland than competitors in For example, as foreign countries usually use several foreign countries."While Hawai'i shippers cited specific examples of transportation subsidies and the use of The views expressed in this publication are those of the authors and foreign-flag vessels by foreign shippers making Hawai'i do not necessarily reflect the position of the College of Tropical shipping uncompetitive, anecdotal evidence on freight Agriculture and Human Resources, University of Hawai'i at Manoa, rates showed otherwise. An example given in the USDA or the Hawai'i Department of Agriculture. (1) USDA, 2003. Geographically disadvantaged farmers and ranchreport is that Hawai'i shippers who believed that they had ers: A case study of Hawaii. Part II of the report on geographically a transportation disadvantage compared to Costa Rica disadvantaged farmers and ranchers, prepared for submission to were "surprised to learn that shipments from countries Congress by the U.S. Department of Agriculture, Agricultural Marsuch as Costa Rica can cost twice as much per ocean keting Service, November 2003. container of pineapples to the mainland than shipments (2) Horizon Lines (as Sea-Land Services, Inc.) is the other major shipping company in Hawai'i. However, most of Horizon's vessels from Hawaii." from the U.S. West Coast, after arriving Hawai'i, go on to serve other This publication describes an assessment of whether Pacific islands such as Guam and return directly to the West Coast Hawai'i farmers do indeed pay higher freight costs for without stopping in Hawai'i.


Most cancer cells undergo the Warburg effect, a shift from oxidative to glycolytic metabolism accompanied by suppression of p53. We have demonstrated leucine to stimulate mitochondrial biogenesis, fatty acid oxidation and p53 in both muscle and fat cells. Accordingly, we now sought to determine if leucine stimulates mitochondrial biogenesis and exit from the cell cycle in A‐375 melanoma cells grown under both standard (11.1 mM) and reduced (5.5 mM) glucose conditions. Increasing glucose reduced mitochondrial mass 50–60% and accelerated cell proliferation by ~20%. Leucine (0.25 – 1.0 mM) dose‐responsively increased mitochondrial mass by 20–40% (p<0.001) under low glucose; its metabolite β‐hydroxy‐β‐methyl butyrate (50 μM) exerted similar effects, while amino acid controls valine and alanine exerted little effect (16–19% stimulation, p<0.05). In contrast, treatments were without significant effect under high glucose conditions. Despite the increase in mitochondrial mass at low glucose, treatments exerted no effect on cell proliferation, p53 or cyclin D. Thus, although both glucose reduction and increased leucine stimulate mitochondrial biogenesis, these effects are insufficient to stimulate p53, induce cell cycle arrest or reduce proliferation in these melanoma cells.


The study aimed to examine strategic empowerment dimensions and its influence on organizational innovation at private sectors in Developed countries. To measure the current study, the researchers used four strategic empowerment dimensions (empowerment culture, innovation culture, managerial ethics, and managerial transparency). A quantitative technique applied in order to analyze the current study.  Sample design refers to the procedure or method the researcher is willing to accept in choosing items for the sample. Research sample was selected using a procedure of random sampling and it was carried out in different banks. A total of 120 questionnaires were distributed, however 109 participants properly filled out the questionnaires. The results show that empowerment culture as strategic empowerment dimension influences significantly and positively organizational innovation at 5% level.  The results show that innovation culture influences as strategic empowerment dimension significantly and positively organizational innovation at 5% level. The results show that managerial ethics influences as strategic empowerment dimension significantly and positively organizational innovation at 5% level. The results show that managerial transparency as strategic empowerment dimension influences significantly and positively organizational innovation at 5% level.  Moreover, all beta value is higher than .001. All models have very high adjusted R2 (0.693, 0.621, 0.712, and 0.763 respectively) indicating the ability of the models explaining the variation of organizational innovation due to variation of independent variables is very high.  The F-value shows that the explanatory variables are jointly statistically significant in the model and the Durbin-Watson (DW) statistics reveals that there is autocorrelation in the models.


The method of high performance liquid chromatographic (HPLC) fingerprint analysis for flavonoids from Houttuynia cordata Thunb. was established with uniform experimental design and information theory evaluation. The fingerprint similarity of 10 batches of Houttuynia cordata Thunb.,which were planted under the same cultivation conditions,was evaluated with the developed method and the fingerprint evaluation software proposed by our laboratory. The similarity was greater than 0.90. The contents of rutin,quercitrin and quercetin were 0.25%-0.34%,0.27%-0.37% and 0.012%-0.016%,respectively. Furthermore,obvious difference was observed among the fingerprints of three kinds of flavonoids produced from different seasons and different parts through principal component analysis and content determination,and the difference from medicinal parts was greater than that from season. This method provide reliable basic information for the specification of flavonoids from Houttuynia cordata Thunb. in the pharmaceutical and medicinal practical application.


The loss allocation of each line, which is produced by each generator, can also be obtained. Test results show that the proposed method can satisfy the power flow equation, the power balance equation and the basic circuit theories.


Summary Starting from a formulation of the reciprocity theorem valid for uniaxial media, we derive symmetry properties for the co-polarized and cross-polarized efficiencies diffracted by a periodically corrugated surface that separates a uniaxial medium from a perfect conductor. These reciprocity relations are proved to be valid for arbitrary orientations of the optic axis of the crystal and for an arbitrary shape of the grating.


Metastatic tissue from an endocervical adenocarcinoma was examined for human papilloma virus (HPV) DNA sequences. Southern blot analysis with 32P-labeled viral probes revealed the presence of about 150 copies of HPV-16 DNA per cellular genome. DNA in situ hybridization of frozen sections with biotinylated probes showed that HPV-16 DNA was exclusively detectable in the nuclei of the malignant epithelial cells and not in the stroma.


The development of green replaceable energy which is renewable and clean has attracted more and more attention duo to the exhaustion of fossil oil and problems of the ecological environment generated by the using of fossil oil in the world today. Biodiesel is an important bio-energy source, but large-scale production of it is restricted because of high prime cost and the limited sources of raw materials. However, as the raw materials of the second-generation biodiesel, development of commercialization technology for producing biodiesel from microalgae has become a focus in the field of bio-energy and CO2 emission mitigation. In this paper, current situation of screening and breeding of energy microalgae, culturing of large scale and harvest technology as well as production engineering are summarized, and the approach of innovation development are discussed.


ionosphere. The relationship J = Q + S E 0 is applied to a one-dimensional ionospheric model to study ion velocities, electron velocities, currents, electric fields, and induced magnetic fields simultaneously and self-consistently. In this model, ion and electron velocities transition smoothly from moving across fieldlines below the dynamo region to moving along fieldlines above the dynamo region. This relationship is valid for the terrestrial ionosphere; replacing J = � E 0 with J = Q + S E 0 in terrestrial models may alter


In September 2007, the National Fisheries Resources Research Institute
carried out a socio-economic survey on Governance in Co-
Management in the fisheries of Lake Victoria. The purpose of the study was to determine the nature and performance of governance of the fisheries resources through co-management structures and systems.


The present disclosure relates generally to materials comprising covalent organic frameworks conductive. The present disclosure also relates to useful materials and sensors for storage and separate gas molecules. .The 2A


Microplastics are being found in large amounts in the environment. In samples from Sweden's west coast 4000-100000 particles of microplastic/kilogram of dry samplewas found. One of the larger pathways into theenvironment for microplastic is believed to be stormwater. Yet there is no standard method to analyse this pollution. This study was made to get an understanding of the amount of microplastic released from two stormwater outlets in Lund and to test density separation as a purification method, a common method used to analyse the samples for microplastic. The sediment by the stormwater outlet where also tested for microplastic. Particles of microplastic were found in the stormwater with a total mean value of 33,7/L and 31,3/L for the different outlets.In the sediment samples the amount of microplastic particles was 8/L and 2/L. The method of using density separation worked well with the water samples however only the inorganic particles were able to be separated whilst for the organic particles it was not possible to use this method. Density separation was not as successful for the sediment samples since not enough of the organic particles were able to be removed to properly quantify the amount of microplastic in the sediment. Microplastic was found in the stormwater that was tested and the method of density separation worked to some extent for the analysis. A more thorough analysis of the stormwater should be performed for more certain values of microplastic concentrations in the stormwater. (Less)


The inverse scattering problem method application to construction of exact solution for Maxwell dilaton gravity system ia considered. By use of Belinsky and Zakharov L A pair the solution of the theory is constructed. The rotating Kerr like configuration with NUT parameter is obtained.


Toinvestigate themechanisms ofa,-adrenergic vascular desensitization, osmotic minipumps containing either saline (n=9)oramidephrine mesylate (AMD)(n=9), a selective a,-adrenergic receptor agonist, were implanted subcutaneously indogswithchronically implanted arterial andright atrial pressurecatheters andaortic flowprobes. After chronic al-adrenergic receptor stimulation, significant physiological desensitization toacuteAMD challenges was observed, i.e., pressorandvasoconstrictor responses tothe al-adrenergic agonist were significantly depressed (p<0.01) compared withresponsesinthesame dogs studied intheconscious state before pump implantation. However, physiological desensitization toacute challenges oftheneurotransmitter norepinephrine (NE)(0.1,gg/kg per minute) inthepresenceof fi-adrenergic receptor blockade was notobserved foreither mean arterial pressure(MAP)(30±7versus 28±5mm Hg)ortotal peripheral resistance (TPR)(29.8+4.9 versus28.9±7.3 mm Hg/lperminute). Inthe presenceofj3-adrenergic receptor plusganglionic blockade after AMD pump implantation, physiological desensitization toNE was unmasked since thecontrol responsestoNE (0.1 jug/kg perminute) before the AMD pumps were now greater (p<0.01) thanafter chronic AMD administration forbothMAP (66+5 versus32±2mm Hg)andTPR (42.6+10.3 versus23.9±4.4 mm Hg/lper minute). Inthepresence of f-adrenergic receptor, ganglionic, plusNE-uptake blockade after AMD pump implantation, desensitization was evenmore apparent, since NE (0.1 ,ug/kg perminute) induced evengreater differences inMAP (33±5 versus109+6mm Hg)andTPR (28.1+ 1.8versus111.8± 14.7 mm Hg/lperminute). Themaximal force of contraction induced byNE inthepresenceorabsence ofendothelium was significantly decreased (p<0.05) invitro inmesenteric artery rings fromAMD pump dogscompared withsaline control dogs. Furthermore, xl-adrenergic receptor density, as determined by[3H]prazosin binding inmembranepreparations from vessels inthemesentery, was decreased (8.2+ 1.0versus18.4± 1.4fmol/mg protein, p<0.001) without any changeinKdintheAMD pump dogscompared withthesaline pump dogs.Inaortic membranes al-adrenergic receptor density inAMD pump dogsdidnotdifler fromsaline pump dogs, buttheaffinity of theaortic receptors for[3H]prazosin binding was decreased (Kd, 0.29±0.07 versus0.14+0.01 nM,p<0.01), andNE-induced displacement of[3H]prazosin binding demonstrated a lossofhigh-affinity binding sites (12±9versus82+2percent, p<0.05). Thus,although endothelial mechanisms donotappearimportant, bothautonomic reflex andbiochemical mechanisms are altered bychronic a£l-adrenergic receptor stimulation intheconscious dog;thealtered autonomic mechanisms affect thephysiological expression of desensitization, whereas separate biochemical mechanisms observed invessels ofdifferent caliber mediate thedesensitization. (Circulation Research 1992;71:1185-1199)


The complex formation between Cu (I) Cl and Cl− was investigated in a 1 M HClO4 ionic medium at 22 °C. In saturated CuCl(s) - Cl− -solutions over the concentration range 0 - 0.25 M Cl− the only complexes observed are CuCl2− and CuCl32−. The complex constants for the formation of these complexes are logβ11 = −1.31 and logβ12= −1.6 respectively. The UV-absorption spectra of CuCl2− and CuCl32− were determined in the wavelength region 220 -370 nm. The absorption of CuCl2− is characterized by a strong band λmax < 200 nm (ε >2.7 · 103) together with a weak band having λmax = 230 nm (ε = 0.7-103). The spectrum of CuCl32− is composed of two bands with λmax = 230 nm (ε = 4.7 · 103) and λmax = 276 nm (ε = 6.1 ·103).


The agriculture sector is the backbone of Indian economy. With the advent of the electric motor, the burden of manual irrigation by the farmer has migrated a lot. Still, there is a problem to turn ON and OFF the motor during night times. In this work, an attempt is being made to build a solution to control the irrigation system remotely from anywhere. The idea is to design a system using the Internet of Things (IoT) technology to control the irrigation system. Here, GSM module is used to communicate with the server. The system takes the input from the farmer through a voice call. The voice is basically used in IVRS system to extract the input from the farmer. Based on the input received from the farmer, the motor is turned ON or OFF. Along with this, the system is integrated with the flow sensor, moisture sensor, temperature sensor, and humidity sensor. The flow sensor is used to sense the amount of water given to the farm. Other three sensors are used to read atmosphere conditions and moisture content present near the crops. The system works as a closed loop system, where sensor reading is used as feedback to determine whether sufficient water has been delivered or not. When the moisture level exceeds the threshold level, the device has an intelligent system that will make a call to inform the farmer to switch OFF the motor. The system reads the environmental condition near the crops and tells the farmer to start irrigation, if needed. Furthermore, the system can be used to provide some suggestions based on the type of the crop to improve farming in order to obtain the maximum yield from the field. This will be future implementation which uses machine learning algorithms to predict the weather conditions and provide suggestions from the data received from the field.


Water temperature residuals, which are taken as the difference between the daily average water temperature (Missouri River, Boonville, Missouri) and the Fourier series regression fit to the data points, are analyzed. A 1-yr record length is used as a base period. The Kolmogorov-Smirnov test is used to determine, for a given number of extracted harmonics, the sample size required to yield a set of normal random variates with mean zero. It is also shown that with only the fundamental harmonic removed, a sample size of at least 180 is required to yield a sample average residual of less than 0.2°F. When the fundamental and higher order harmonics are removed, this sample size is reduced considerably.


The study shows that there is the increase in foreign direct investment by type of economic activity to identify increased investment attractiveness. It is investigated that the trend of efficiency of foreign direct investment in Ukraine in relation to economic development is negative for revealing the level of economic development. Article analyzes the growth of the ratio of foreign direct investment per capita in percent in order to identify the need to increase the international investment attractiveness of Ukraine. Author considers that to increase the level of foreign investment it is necessary to promote the development of interregional cooperation: economic growth, decent working conditions, implement quality education, information-communication technologies, tourism development, foreign trade, agricultural sector, construction development, transport infrastructure, personnel training, development of industry and energy.


MinterEllison's corporate tax experts have advised on some of the most significant deals of recent times. We are highly responsive and passionate about cutting through the complexity to deliver clear, practical solutions and outstanding results for our clients. Our team has extensive experience in mergers and acquisitions, divestments, reorganisations, demergers, capital raisings, IPOs and private equity deals. We also have strong credentials on major cross border transactions involving Asia and beyond. Structure advice is implemented efficiently through drafting and negotiating transaction documents, tax warranties, indemnities and disclosure materials. Our team is experienced in managing revenue authorities on corporate transactions and obtaining tax rulings as well as drafting tax sharing and funding agreements.


The purpose of this study was to explore dose dependent vasodilation responses of the individual compounds of Shakuyakukanzoto (SKT), a 1:1 combination of extracts from Paeony and Licorice roots: glycyrrhetic acid (GA), paeoniflorin (PF), and isoliquiritigenin (ISO). 20 young, healthy participants (13M/7W) had four intradermal microdialysis fibers placed in the forearm skin for local delivery of: 1) control (diluent), 2) GA, 3) PF, or 4) ISO at doses of 1, 10, 50, or 100 μm. Cutaneous red cell flux, an index of skin blood flow, was measured by laser‐Doppler flowmetry. Blood pressure (BP) was monitored continuously during fixed measurement periods via finger photo‐plethsmography (Finapres). Cutaneous vascular conductance (CVC) was derived as red cell flux divided by BP and was normalized as a percentage of baseline (%CVCbl, saline at 4 μl/min) and the maximum CVC (%CVCmax, 28mM sodium nitroprusside at 4 μl/min, local temperature 43°C). Mean CVC did not statistically differ between baseline and individual compound plateau (average of last 5 minutes of infusion) at any dose. The peak flux was significantly higher from baseline at doses 50 and 100 μm for control (56.17±13.32 vs. 96.73±20.32 and 44.64±5.68 vs. 80.21±9.54), PF (62.70±10.09 vs. 115.72±16.16 and 62.37±16.2 vs. 150.21±34.26), GA (48.37±4.41 vs. 71.76±7.16 and 58.36±13.68 vs. 91.51±3.41), and ISO (96.50±23.20 vs. 128.57±27.90 and 44.95±8.78 vs. 91.18±20.37) (p<0.05). However, peak CVC was significantly higher only for GA at dose 50 μm, as well as for control and PF at dose 100 μm compared to their respected baselines (GA: 0.60±0.06 vs. 1.01±0.11, control: 0.61±0.09 vs.1.55±0.61, PF: 0.81±0.20 vs. 1.30±0.30, p<0.05). There were no other significant differences between the control and the compounds for change in CVC from baseline to peak (ΔCVC), %CVCbl, or %CVCmax. There were no significant differences between doses 1, 10, or 50 as compared to 100 μm for other variables. These results suggest that the doses may be lower or below the threshold to cause a vasodilatory effect. Future studies that investigate higher doses of these compounds may be needed.


∗The need for technology nowadays is inevitable, leading to the increased growth of technology-based projects. But in fact, many technology-based projects facing problems when executing projects, especially about their quality. Quality Management System (QMS) is one quality process framework that has been used for monitoring and ensuring quality implementation on a process for creating and deliver a product. Nevertheless, the QMS implementation in the technology-based project faces a challenge of its effectiveness in improving quality. Such a challenge is due to the dynamic complexity that arises in the implementation. Uncovering such dynamics complexity can provide insights on strategy for improvement. In this regard, this study presents a conceptual model to understand the complexity of the QMS implementation in a technology-based company by using system dynamics modeling. Through Causal Loop Diagram (CLD) and system diagram, the conceptual model shows the key factors needed to improve the QMS process to be more effective, such as expert workforce and QMS adaptability.


Curdy yoghurt was prepared with asparagus extracts, selected strains of lactobacillus,and other ingredients through formula optimization and processing improvement. The nutritious product tastes good and has typical flavor of asparagus. It is especially good for the middle aged and senior citizens.


Abstract Epistemic beliefs are individual beliefs about knowledge and knowledge acquisition. Empirical studies indicate that learners' epistemic beliefs influence their learning processes and success (e.g. motivation, text comprehension, learning strategy selection, grades). Teachers and trainers can support their apprentices in developing preferable epistemic beliefs to facilitate learning. To do this, instructors need information on learners' current beliefs for lesson planning and monitoring epistemic beliefs development. The following paper reports the validation of a tool for generating this kind of information: the Instrument for Measuring Epistemic Beliefs in Marketing. The instrument validation is based on three studies (Study I: 225 university trained business administration students; Study II: 531 vocationally trained retailers/wholesalers; Study III: 179 vocationally trained bank assistants). It reveals high reliabilities (α values about .700), stable factor structures, and incremental validity in comparison to general epistemic beliefs. The new questionnaire is able to predict grades in marketing and can be used to diagnose apprentices' epistemic beliefs for adjusting instruction to learners' preconditions. Findings based on the new instrument indicate that apprentices show partly unfavourable epistemic beliefs. As a result, supporting learners in developing preferable beliefs provides an opportunity to increase their learning success.


Anthrax toxin is a three-protein toxin that must first assemble before carrying out its physiological function of menacing its eukaryotic host. Much has been done, therefore, to study its assembly both in vitro and on cell surfaces. The three proteins that comprise the toxin are protective antigen (


For the next five years Chinese Railways will concentrate on upgrading and electrification of existing routes in a determined effort to boost capacity without incurring disproportionate costs--a process in line with recent political reforms. From then on the long planned programme to build new lines will be reactivated with construction moving at the rate of 2,000 km a year. In the meantime Chinese engineers are investigating how best they can prepare for the future in terms of rolling stock design and production. Introduction of modern signalling and up-to-date maintenance techniques will follow as the equipment and methods most suited to China's unique circumstances are selected.