Background Abdominal aortic aneurysm (AAA) is a multifactorial disease with strong genetic components. Various genetic loci have been associated with clinical AAA, but few studies have investigated pathological AAA, an intermediate phenotype of the disease. Methods We examined 2263 consecutive autopsies of older Japanese subjects from a study on geriatric diseases in Japanese individuals (The JG-SNP study). The presence of AAA was determined with a pathological diagnosis during autopsy. Single nucleotide variants (SNVs) associated with AAA were determined with an Illumina HumanExome Beadchip array. Logistic regression analyses were performed to determine genetic associations. Age, gender, and other risk factors of AAA were analyzed as covariates. Results 118 subjects with AAA and 2145 subjects without AAA were analyzed in a case-control setting. No variants reached significance after applying the Bonferroni correction (P < 2.05×10−6). The strongest associations were found with rs3750092 (p.E321G, OR: 0.36, 95% CI: 0.24–0.56, P = 6.09 × 10−6), a variant in the WAS/WASL interacting protein family 3 (WIPF3), and with rs1051338 (p.T16P, OR: 2.50, 95% CI: 1.70–3.66, P = 2.79 × 10−6) and rs2246942 (intronic, OR: 2.32, 95% CI: 1.58–3.41, P = 1.61 × 10−5), variants in the lysosomal acid lipase A (LIPA). LIPA is essential for macrophage cholesterol metabolism. Immunohistological analyses of WIPF3 protein in AAA samples from three subjects revealed that WIPF3 was expressed in macrophages of atheromatous plaques. Conclusions This study suggests that WIPF3 and LIPA, both of which are expressed in the macrophages are involved in pathological AAA. These results should be regarded as hypothesis-generating; thus, replication study is warranted.


Several tumor factors are associated with papillary thyroid cancer. Most studies do not compare the expressions of these factors in the primary tumors and in their associated cervical metastasis.


We develop further our model of affirmative action as help (Pratkanis & Turner, 1996b; Turner & Pratkanis, 1994) by looking at the impact of aid on the donor. White Americans often take one of three approaches toaffirmative action. First, they can reject affirmative action because of their own personal frustrations. Second, they can engage in selective aid that maintains the basic patterns of social dominance. Both of these approaches can damage the psychological functioning of Whites. Third, White Americans can proactively seek to remove discriminatory barriers in a process we call democratic altruism, thereby opening the possibility of learning from diverse others and growth as a person. We conclude by discussing tactics for promoting democratic altruism.


In recent years,some projects request more fast FFT calculating time,but the existing FFT implementing methods can't satisfy the requirements,which restricts the improvement of the engineering performance.In view of this question,this paper proposes the 2-dimension FFT algorithm and its improved method,which is implemented by FPGA.The simulation and experimentation results show that the proposed method is accurate and reliable,easy to implement,has fast calculating speed to shorten the FFT time and satisfies the project requirement.


Paralytic calcaneus deformity due to weak planter flexors of ankle is difficult to manage conservatively. Tendon transfers with or without foot stabilisation have been in practice to regain muscle balance and correct deformity. Release of plantar fascia, osteotomy of vertically inclined calcaneum with displacement of posterior fragment posterosuperiorly alone or in combination with tendon transfer to heel or translocation of peroneus longus gives immediate correction of calcaneocavus deformity with varying degree of increase in power of plantar flexors. It preserves the mobility of the foot, and increases the length or shorter foot. In this series of 23 patients, 5(21.73%) had excellent results,13(56.52%) had good results and 4(17.40%) had fair results. One (4.35%) had proof results. It appears to be procedure of choice in selected cases of post-polio calcaneocavus deformity for improvement of shape and function of foot with mobility.


In this paper, design of ZCS soft switching converter-based gate driver monolithic integrated circuit (IC) is presented. The circuit is developed in B6035 high-voltage bipolar process technology of Sichuan Institute of Solid-state Circuit. It consists of voltage detection logic, switch driving, isolation transformer excitation voltage blow-down unit circuits. The circuit and the isolation driving transformer jointly comprise the driving circuit of power MOS transistor. The principle of ZCS switching resonance is used to design the circuit. The circuit can drive MOS transistor with low power efficiently, and is especially suitable for the driving circuit of high-power ZCS soft-switching power supply.


Game theoretic learning in multiagent systems is a rapidly developing area of research. It gained popularity since the wide range of optimization problems in multiagent systems can be reformulated in terms of potential games, where the set of potential function maximizers represents the set of optimal states. The crucial point of such approach is the design of local decision rules that leads the system to a potential function maximizer. In this paper, we consider the independent log-linear learning procedure applicable to continuous action potential games. We provide the analysis of the stochastic stability of potential function maximizers in case of continuous action games. To analyze the behavior of the underlying Markov chain, we develop a new method for approximating the initial chain with continuous states by chains whose long run properties can be established. After that, we study the finite time behavior of the algorithm with a definite time-dependent parameter and obtain settings that guarantee an efficient implementation of the learning procedure under consideration.


Summary of art and culture education (Le Point) programWeek Main tasks1 Experience body movements by using the moving tunnel and 6 motions (pushing, smashing, twisting, knocking, slicing, sliding)2 Experience body movements by using the hedgehog ball, group interaction by spontaneous body contact, find a relevance between activeness and passiveness (massage each other with balls, rolling each other's body, contact each other's backs each other to feel body temperature)3 Make one's own creative space and show one's body performance by using spandex fabric (imagine fabric to be a big blue ocean, imaging oneself as a creature of the ocean)4 Create neology and create improvised movements which are inspired by the neology5 Compare body movements using lace and chiffon fabric (toss fabrics, balanced walking while covering face with chiffon fabric)6 Appreciate art, express one's own emotion, make drama (express daily emotions of sadness, anger, happiness with body movements, use neutral short word cards indifferent short word card to make a drama, select a word card and express it with motion)7 Arrange flash card and express it by dance (arrange flash cards which are named with various adjectives on a whim, and express it)8 Experience the sense of closeness by improvised touching and interaction (sit on the same chair, contact each other closely, exchange numerous eye contact to make an appreciating movements)9 Be a Picasso (fragment images of what one sees in real world and imagine it with others)10 Creative dancing and leaving space by mimicking the march of flocking birds (make a big organic body using every single body, experience cooperation)11 Play images of meaningless world through body movement and vocal sound (imagine an absolutely new world by hearing other's gibberish)12 Extension of movement, observe contraction, create a new movement by using latex band (feel one's own and other's muscles with the extension and contraction of latex band)13 Write a story of one's own external self image, and inner inside image (with no limitations or instructions, just express own image using words)14 Body percussion with Brazilian musician (one's body becomes a drum. Rhythm can be made by percussing one's own and other's body parts)15 Compose a small piece of performance by combining previous learning 116 Compose a small piece of performance by combining previous learning 217 Final recital in the theater


The utility model relates to the field of wind power generation, and discloses a perpendicular shaft double-rotor wind power generation device. The perpendicular shaft double-rotor wind power generation device is provided with upper and lower wind wheel structure layers and a double-rotor structure, and under the reverse action of a reversal box, a rotor coil and a rotor magnetic pole inside the double-rotor structure rotate in the opposite directions to generate power. Compared with a single wind wheel structure, because the double wind wheel structure layers can double wind sweeping area, the output power of the wind power generation device can be improved, the minimum available wind speed can be decreased, and the perpendicular shaft double-rotor wind power generation device has broader application prospects.


Introduction Buoyancy is one of the very important parameters determining swimming skill. Some reports indicate that buoyancy affects a swimmer's performance (Cureton, 1933, 1951; Chatard et al., 1990). Swimming is an exercise performed horizontally in water. A human body floating in water is always affected by two kinds of physical influence: buoyancy and gravity. Generally, in a horizontal posture, there is a "gap" between the center of buoyancy (CB) and the center of mass (CM), considering that the CB is around the head and the CM is around the legs (Hay,1993). The longer the distance between the CB and CM (D), the bigger the torque in the water. This causes the legs to sink and is a factor causing reduced performance. Thus, examining the relationship between the magnitude relation or positional relation of these two forces and the swimmer's performance provides an important index to evaluate swimming skill. Past reports have examined the effect on swimming performance of differences of gender, arm position, and lung volume (Gagnon & Montpetit, 1981; McLean & Hinrichs, 1998, 2000; Zamparo et al., 1996). However, these studies alone cannot provide sufficient explanation for the change of buoyancy affecting human bodies in water. The data generated by these studies reflect samples in extremely restricted environments. For example, some data samples were focused on full expiration "All measurements were made when the subject had achieved the state of full expiration" (Gagnon & Montpetit, 1981). Others examined CB positions with phased lung volumes measured separately "CB was computed from the average of three measurements of five different lung volumes (0, 25, 50, 75, and 100% of vital capacity, VC) with participants in a prone position for each submersion level" (McLean & Hinrichs, 2000). These samples cannot clarify how buoyancy is changed by the continuous cycle of repeated expiration and inhalation (the breathing cycle). Therefore, this research project will examine the increase and decrease of buoyancy and the migration dynamics of CB position associated with breathing as well as the relationship between the D and performance based on changes in the force exerted in a vertical direction on hands and feet with changes in lung ventilation while a swimmer maintains a horizontal position in the water.


Laser assisted surgeries are very common now and replacing conventional cold steel procedures because their potential of offering bloodless field, short surgical time, small learning curve, user friendly, better machines with precise control and minimal tissue charring. Besides having said this, it has potentially serious complications if precautions are not taken care of, preoperatively and intra-operatively. The complication may vary from temporary reversible to even permanent and life threatening. Discussed in this case report is one such dangerous unlucky incident we encountered during a diode laser assisted subglottic stenosis correction, when the laser resistant endotracheal tube busted in the respiratory tract with some burns of the tracheal mucosa and distal part of the tube flew into the lower respiratory passage.This case report intends to be published to bring into notice this rare but possible fatal complication of this surgery and its management to the budding Laser savvy surgeons.


In this work, we explore a variety of solitary wave ansatze and periodic wave ansatze to some nonlinear equations. Three complex systems of nonlinear equations that appear in mathematical physics are investigated. We derive abundant soliton and periodic wave solutions for the coupled Higgs field equation, the Maccari system and the Hirota–Maccari system. The results obtained show that these three coupled equations exhibit the richness of explicit solutions: solitons, periodic and rational wave solutions.


This report describes the development of a surfactant-enhanced alkaline flooding system that is applicable to specific reservoir conditions in Wilmington (California) field. The cost of the chemicals for an ASP (alkali/surfactant/polymer) flood is calculated to be $3.90/bbl of oil produced, with 78% of that cost attributable to polymer. This research included phase behavior tests, oil displacement tests, mineral dissolution tests, and adsorption measurements. It was discovered that consumption of low pH alkalis is low enough in the Wilmington field to be acceptable. In addition, alkali dramatically reduced surfactant adsorption and precipitation. A mixture of NaHCO3 and Na2CO3 was recommended for use as a preflush and in the ASP formulation. Research was also conducted on the synergistic effect that occurs when a mixture of alkali and synthetic surfactant contacts crude oil. It appears that very low IFT is predominantly a result of the activation of the natural surfactants present in the Wilmington oil, and the sustained low IFT is primarily the result of the synthetic surfactant. It also appears that removal of acids from the crude oil by the alkali renders the oil more interfacially reactive to synthetic surfactant. These phenomena help to explain the synergism that results from combining alkalimore » and synthetic surfactant into a single oil recovery formulation. 19 refs., 24 figs., 10 tabs.« less


Thiol-derivatised I–VII nanoparticles of AgI (7–16 nm) are prepared in large quantities by the reaction of silver nitrate with potassium iodide containing 1-thioglycerol in aqueous solution.


In a split-plotfield trial, the effect of foliar (F) application of 0 or 20 kg N, 2 kg P or 20 kg N + 2 kg P ha−1.was studied on the composition (analysed by GLC) and yield of fennel essential oil constituents grown with two soil (S) levels (60 kg N + 27 kg P and 90 kg N + 0 kg P ha−1). Camphene and dfenchone, both being bicyclic monoterpenes, and d-α-pinene, another bicyclic monoterpene showed a similar trend (R = 0.87) and their contents were maximum with FN20P2 at both soil levels. Methylchavicol and anethole (Phenylpropanoids) exhibited parallel trends (R = 0.56), with the control giving higher values at both soil levels. Interestingly, there was a negative correlation between some of the constituents, e.g. anethole versus d-fenchone (R = −0.99), anethole versus camphene (R = −0.87), and methylchavicol and d-α-pinene (R = −0.71), suggesting that the synthesis of the one constituent was at the expense of the other. Soil application of N and P enhanced the contents (%) of the phenylpropanoids (anethole ...


Chronic cough is a common symptom,at least 10% of cases is refractory to medical treatment of common diseases,some conditions may be related to vocal cord dysfunction.Vocal cord dysfunction is a respiratory disorder caused by paradoxical closure of the vocal cords during the respiratory cycle,present as obstructive airway symptoms,or only chronic cough in some cases.Speech pathology management is effective for chronic cough caused by vocal cord dysfunction.

Key words:
Chronic cough; Vocal cord dysfunction; Speech pathology


We describe a novel spatial filtering approach to the localization of cortical activity accompanying voluntary movements. The synthetic aperture magnetometry (SAM) minimum‐variance beamformer algorithm was used to compute spatial filters three‐dimensionally over the entire brain from single trial neuromagnetic recordings of subjects performing self‐paced index finger movements. Images of instantaneous source power ("event‐related SAM") computed at selected latencies revealed activation of multiple cortical motor areas prior to and following left and right index finger movements in individual subjects, even in the presence of low‐frequency noise (e.g., eye movements). A slow premovement motor field (MF) reaching maximal amplitude ∼50 ms prior to movement onset was localized to the hand area of contralateral precentral gyrus, followed by activity in the contralateral postcentral gyrus at 40 ms, corresponding to the first movement‐evoked field (MEFI). A novel finding was a second activation of the precentral gyrus at a latency of ∼150 ms, corresponding to the second movement‐evoked field (MEFII). Group averaging of spatially normalized images indicated additional premovement activity in the ipsilateral precentral gyrus and the left inferior parietal cortex for both left and right finger movements. Weaker activations were also observed in bilateral premotor areas and the supplementary motor area. These results show that event‐related beamforming provides a robust method for studying complex patterns of time‐locked cortical activity accompanying voluntary movements, and offers a new approach for the localization of multiple cortical sources derived from neuromagnetic recordings in single subject and group data. Hum. Brain Mapping 2005. © 2005 Wiley‐Liss, Inc.


1. Kirstin A. M. Nackers, MD*
2. Patricia Kokotailo, MD, MPH*
3. Sharon J. L. Levy, MD†

1. *Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI.

2. †Division of Developmental Medicine, Boston Children's Hospital, Boston, MA.

The American Academy of Pediatrics recommends screening for alcohol and other drug use at adolescent health supervision visits and appropriate acute-care visits, (1) yet many clinicians find addressing substance use with youth to be a challenge.

After completing this article, the reader should be able to:

1. Describe the use trends for alcohol and common other drugs by youth in the United States.

2. Explain the primary care clinician's role in screening and management of alcohol and substance use.

3. Using motivational interviewing techniques, adopt an in-office brief intervention across the spectrum of adolescent substance use.

4. Analyze the utility of urine drug testing in various clinical situations, such as random screening in a low-risk patient/population, testing an adolescent who self-reports ongoing substance use, monitoring adherence to treatment for a substance use disorder, and evaluating a patient with signs/symptoms of acute toxicity.

Adolescent drug and alcohol use remains a major issue in the United States. The American Academy of Pediatrics (AAP) recommends screening for use of these substances at adolescent health supervision visits and appropriate acute-care visits. (1) Primary care clinicians (PCCs) serve an important role in both the identification and management of alcohol and substance use disorders (SUDs). This role comes with many challenges, including managing the dynamics of families that may be in crisis, issues of adolescent confidentiality, and high variability of local resources to support patients in need of treatment for SUDs. In this article, we review the epidemiology of alcohol and substance use, the approach to screening and treatment, the issue of adolescent confidentiality, and the role of urine drug testing.

### Epidemiology

The epidemiology of adolescent substance use must be …


We first recall the sufficient conditions for the existence of a periodic output of a modified Elman neural network with a periodic input found by using Mawhin's continuation theorem of coincidence degree theory. Using this result, we obtain sufficient conditions for the existence of a periodic output for an output hidden feedback Elman neural network with a periodic input. Examples illustrating these sufficient conditions are given.


Mothers of children with mental retardation with malformations, epilepsy and Down's syndrome and matched controls were tested for autoantibodies to nuclear, thyroid, gastric, smooth muscle and mitochondrial antigens, and for ABO and rhesus blood group antigens. There was a small but statistically significant (P < 0·05) excess of antinuclear antibodies among mothers of children with Down's syndrome, and an excess of thyroid antibodies (P < 0·05) and rhesus D‐negative blood group antigens (P < 0·01) among mothers of children with malformations. Thus autoimmune processes in the mother may have a detrimental influence on normal tissue development in the fetus.


LAUGHLEN * has presented a reliable test for syphilis which can be performed in a few minutes, needs little equipment, no tubes and is inexpensive. It is especially adapted for routine use in small hospitals and clinics and for emergency use. The Laughlen test has as its base a precipitation test antigen, as used in the Kahn test, to which has been added balsam and Scarlet R. dye. The water insoluble dye colours the suspended particles of the antigen, but does not colour to any extent the liquid in which they are suspended, thereby increasing the visibility of a positive reaction. The Laughlen reagent (antigen), which is supplied in the inactive state to insure the maximum stability of the antigen, is stable for a minimum of six weeks. It is stored normally at room temperature or, in hot weather, in a cool place. For activation i c.c. of the reagent is measured into a tube and to this is added IO per cent. saline in the quantity stated on the label, usually OKI5 c.c. The fluid is mixed by shaking and is set aside at room temperature for twenty-four to forty-eight hours.


Women living in rural Australia who are labelled as depressed, by either themselves or professionals, contend with spatial injustices of limited service provision that converge with the dominant constructions of mental health and knowledge authorisation. Informed by a feminist social constructionist standpoint, semi-structured interviews were conducted with 27 women living in rural New South Wales in Australia. This paper explores how rural women navigate experiences labelled as depression. The women's stories conveyed an overwhelming sense of loss, abuse and betrayal, and the pathologisation of their experiences of structural violence and oppression is of significant concern. Yet, the women also showed agency by using to their best benefit multiple and often divergent explanations for their experiences of depression. While many accepted the diagnosis of their symptoms, most resisted a sole pathological cause and actively created individually meaningful narratives of their depression experiences. The language of 'depression' provided a passport for some, allowing access to formal supports that would have otherwise been unavailable or highly stigmatised. Rurality and the associated structural disadvantage, particularly in regard to service provision, was only marginally present in the women's stories. The alternative narratives of healing uncovered challenge the centrality of formal service delivery to the wellbeing of a community. Further, while the pathologisation of structural oppression must be resisted, the women's stories demonstrate the importance of not invisibilising the agency they demonstrate in this difficult and contested space.


Four oligonucleotides (15 mer) 13–16 and their conjugates 17–20 in which psoralen was covalently linked to 5′ end were synthesized. Compounds 16 and 20 contain the sequence which is complementary to the sense strand covering the first four codons and the upstream sequence close to the ribosome binding site of c-Ha-ras mRNA. It was found that compounds 16 and 20 inhibited the growth of cells that had been transformed by the c-Ha- ras plasmid activated c-Ha- ras oncogene. Compound 20 that carried psoralen was more efficient in inhibiting the growth of transformed cells than compound 16 without psoralen, suggesting that the psoralen might have increased permeability of oligodeoxynucleotides. A model experiment of duplex formation was pertinent to the idea that the inhibitory effect was caused by RNase H activity.


A nonvolatile 32 Mb ferroelectric random-access memory with 0.25 /spl mu/m design rules uses ATD control for SRAM applications and a common-plate folded bit-line cell scheme with current forcing latched sense amplifier for low noise level without cell area penalty.


The invention relates to a sound absorbing heat preservation wall which comprises a wall body, a wall board, a levelling structure and a keel, wherein the wall board comprises veneer boards and heat preservation boards arranged at the inner part of the veneer boards; grooves are formed in the four side surfaces of the wall board; the grooves are recessed in the four side surfaces and are stretched into the inner parts of the heat preservation boards; the cross-section shape of the keel is H-shaped; the keel is provided with an outer bar and an inner bar; the outer bar is butted with the grooves in the wall board; fixing holes are formed in the inner bar; the levelling structure comprises a screw nut, a screw bolt and a U-shaped levelling rod; one end of the screw bolt is fixed on the wall body, and the other end of the screw bolt penetrates through the levelling rod and is in threaded connection with the screw nut; and both ends of the levelling rod penetrate through the fixing holes in the inner bar. The sound absorbing heat preservation wall has the benefits that the properties of environmental protection, fire protection, sound absorption and heat preservation of the whole sound absorbing heat preservation wall are good; the structure is stable and durable; both the mounting and dismounting are convenient; the manpower cost and the time cost are saved; and besides the materials used by the heat preservation wall can be used circularly; and the material cost is saved.


A field experiment was conducted to study the effects of ridge direction on flue-cured tobacco micro-ecological environment and quality of flue-cured tobacco leaves at different positions of vigorous growth period.The results indicated that the highest CO2 concentration appeared in the treatment of south-north ridge direction,but the highest light intensity occurred in the treatment of east-west ridge direction,and the lowest light intensity in plant upper 10 cm,plant top and plant bottom all was in the treatment of southeast-northwest ridge direction.The temperature in plant upper showed that south-north ridge directionsoutheast-northwest ridge directioneast-west ridge direction.The wind speed in plant upper 10 cm and plant bottom displayed that east-west ridge directionsouth-north ridge directionsoutheast-northwest ridge direction.However,the wind speed in plant middle showed southeast-northwest ridge directioneast-west ridge directionsouth-north ridge direction.


Hotel Santika Premiere Beach Resort provided education and training to all employees to improve their performance. Through education and training, it is expected to able to improve the employees' performance in terms of their quality of service. To analyze the influence of education and training, an analysis on the effectiveness of education and training needed to be conducted. From the analysis, it was found that the percentage of the employees' performance was 58,4%. The result indicated that aducation and training had an influence on the performance of the employees.


The aim of this background paper is to provide a context for a national accounting-based approach to the valuation of ecosystem services and assets. In doing so, it is hoped that this material can support an informed discussion on how the variety of approaches to environmental valuation that have been developed may be best applied for the implementation of the System of Environmental-Economic Accounting Experimental Ecosystem Accounting (SEEA EEA) framework.


Recent empirical analysis of interest rate markets documents that bond demand and supply directly affect yield curve movements and bond risk premium. Motivated by those findings we propose a parametric interest rate model that allows for segmentation and local shocks in the term structure. We split the yield curve in segments presenting their own local movements that are globally interconnected by smoothing conditions. Two classes of segmented exponential models are derived and compared to successful term structure models based on a sequence of out-of-sample forecasting exercises. Adopting U.S. interest rates data available from 1985 to 2008, the segmented models present overall better forecasting performance suggesting that local shocks might indeed be important determinants of yield curve dynamics.


Our study identified the mechanism by which Dnmt3bas lncRNA and Dnmt3b cis-regulatory elements control inducible expression and alternative splicing of Dnmt3b . Dnmt3bas knockdown increases transcriptional induction and decreases H3K27me3 at Dnmt3b upstream elements, 11 suggesting that PRC2 targeting by Dnmt3bas fine-tunes Dnmt3b induction. Moreover, we 12 identified the catalytically inactive Dnmt3b6 as a major isoform in naïve ESCs. Alternative 13 splicing switches to include exons during transcriptional induction, thus generating the 14 catalytically active isoform, Dnmt3b1 . While Dnmt3bas overexpression attenuates Dnmt3b 15 induction, we observed a relative increase in the Dnmt3b1 isoform. Towards a mechanism, our data demonstrated that hnRNPL, a Dnmt3bas binding partner, promotes exon inclusion. RNA alternative transcriptional this two-pronged DNMT3B can be tightly controlled short developmental specificity DNA Dnmt3b pattern mimicking the expression of Dnmt3b observed in vivo . The chromatin modification state of proximal and distal enhancers and enhancer-promoter looping complemented the Dnmt3b transcriptional state, thus establishing the role of the upstream cis-86 regulatory elements in regulating Dnmt3b expression. Whereas we observed no discernable effect on Dnmt3b basal expression, the induced expression of Dnmt3b was inversely affected by downregulation (KD) or overexpression (OE) of Dnmt3bas . Interestingly, we observed an increase in H3K27me3 at the cis-regulatory elements pre-induction in undifferentiated OE cells suggesting the role of Dnmt3bas in the regulation of PRC2 activity at these sites. Additionally, 91 higher enrichment of H3K27Ac and an increased interaction frequency between enhancer and promoter were observed in the KD cells post-differentiation. Next, we asked if changes in Dnmt3b expression in Dnmt3bas manipulated cell lines affected the alternative splicing (AS) of 94 Dnmt3b . This analysis revealed that in WT undifferentiated 2i-ESCs, catalytically inactive Dnmt3b6 is expressed as the major isoform. Upon Dnmt3b induction, the AS switches to exon inclusion, promoting the expression of the catalytically active, Dnmt3b1 as the major isoform. However, in Dnmt cells, we observed increased exon inclusion. Our systematic splicing the of


A novel mechanism to derive self-entanglement-free (SEF) path for tethered differential-driven robots is proposed in this work. The problem is tailored to the deployment of tethered differential-driven robots in situations where an omni-directional tether re-tractor is not available. This is frequently encountered when it is impractical to concurrently equip an omni-directional tether retracting mechanism with other geometrically intricate devices, such as a manipulator, which is notably relevant in applications like disaster recovery, spatial exploration, etc. Without specific attention to the spatial relation between the shape of the tether and the pose of the mobile unit, the issue of self-entanglement arises when the robot moves, resulting in unsafe robot movements and the risk of damaging the tether. In this paper, the SEF constraint is first formulated as the boundedness of a relative angle function which characterises the angular difference between the tether stretching direction and the robot's heading direction. Then, a constrained searching-based path planning algorithm is proposed which produces a path that is sub-optimal whilst ensuring the avoidance of tether self-entanglement. Finally, the algorithmic efficiency of the proposed path planner is further enhanced by proving the conditioned sparsity of the primitive path validity checking module. The effectiveness of the proposed algorithm is assessed through case studies, comparing its performance against untethered differential-driven planners in challenging planning scenarios. A comparative analysis is further conducted between the normal node expansion module and the improved node expansion module which incorporates sparse waypoint validity checking. Real-world tests are also conducted to validate the algorithm's performance. An open-source implementation has also made available for the benefit of the robotics community.


Objective To study the effect of endodontic interappointment emergencies(IAE) therapy with Dexamethasone. Methods 117 teeth with pulpitis were selected and divided into trial group and control group randomly. DXM was used as disinfection in 59 teeth of trial group and FC in 58 teeth of control group. The IAE incidence rate of two groups were analyzed. Results The IAE incidence rate of trial group is 3.39% and that of control group is 20.69%. There are statistical differences between two groups in upback and bearing drug 12 h. The IAE incidence rate of front teeth is 3.84% and that of back teech is 14,28%. Conclusion The IAE incidence rate of the back teeth is significantly higher than that of the front teeth. There is statistic difference of the effect between the two drugs. The effect of D.X.M for IAE is better than FC.


This article critically explores Nuno Venturinha's project of capturing how we are situated in reality, a project grounded in the conviction that the closure of knowledge and the openness of experience are compatible. To this end, I will explore how an approach complementary to Venturinha's method—one which regards the passive and the active in knowledge as rooted in a single, underlying original form of consciousness—would deal with the issue of justifying contingency without falling into either scepticism or empiricism.


Introduction Due to the mild-to-moderate iodine deficiency in Poland, in 1997 iodine prophylaxis based on obligatory salt iodization was introduced. We attempted to evaluate the effectiveness of such prophylaxis, based on over 20 years of observations of iodine supply in school-aged children in Opoczno district (Central Poland). Material and methods A group of 603 children (316 girls and 287 boys), aged 6–14, was examined at 4 time points: in the years 1994, 1999, 2010 and 2016. The children were tested for urine iodine concentration (UIC) and in each child the thyroid volume was measured ultrasonographically. Results The median UIC in 1994 (45.5 μg/l) indicated moderate iodine deficiency, while after introducing prophylaxis it corresponded to adequate values (1999 – 101.1 μg/l, 2010 – 100.6 μg/l, 2016 – 288.3 μg/l); however, the last value was higher than the previous two. The thyroid size, assessed by ultrasonography and presented as volume/body surface area (V/BSA), in 1994 was 6.55 × 10–6 m; this value was higher than at other time points (2.73 × 10–6 m in 1999, 2.73 × 10–6 m in 2010, and 2.70 × 10–6 m in 2016). Conclusions Iodine prophylaxis has proved effective in eliminating iodine deficiency. In recent years, the diversification of iodine sources, despite the reduction of salt consumption, has led to an increase in median UIC to values close to the upper limit of UIC, accepted as normal. Further increase in iodine supply may be unfavourable for health; therefore constant monitoring of iodine prophylaxis is required.


The study is to extract the competency in the training program design of the pre-service adolescence-leaders. For this study, we analyzed curriculum of the Korean university as well as cyber university divisions, and reviewed literatures relating to adolescence study and competency. Based on analysis, it is led to the categories, domain and elements as competency of the pre-service adolescence-leaders. Categories are composed of knowledge, skill, attitude, and domain is extracted according to each category, finally it is extracted various elements in each domain. The results of this study can be used as basic contents needed in the development for the curriculum in pre-service adolescence- leaders. The implications for this study are not only to provide the theoretical basis paradigm in the study of adolescence, but also to suggest the systematic training program of the pre-service adolescence-leaders.


Three dimensional (3D) whole‐heart magnetic resonance imaging (MRI) has become an important imaging modality to assess cardiovascular diseases. The main challenges for 3D whole‐heart MRI are long acquisition times, required to achieve high spatial resolution, and image artefacts due to physiological motion. Here we propose to overcome these problems by the combination of an interleaved Radial Phase Encoding trajectory and the Phase Ordering with Automatic Window Selection method. This Radial Phase Encoding‐Phase Ordering with Automatic Window Selection approach yields fast 3D whole‐heart imaging with a high isotropic resolution and high navigator efficiency even for extremely irregular breathing. Numerical simulations were performed and Radial Phase Encoding‐Phase Ordering with Automatic Window Selection was implemented on a clinical scanner. A comparison between the proposed method and a respiratory gated 3D Cartesian approach was carried out. Radial Phase Encoding‐Phase Ordering with Automatic Window Selection leads to a better depiction of coronary arteries and an increase in navigator efficiency. In addition to a high resolution image, this method also provides dynamic respiratory information without an increase in scan time. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.


Article history: Received: August 12 2019 Received in revised format: December 27 2019 Accepted: January 31 2020 Available online: January 31 2020 Project scheduling models with resource constraints and multi-mode activities aims to create a schedule for carrying out activities considering precedence constraints and available resources in order to minimize the project duration. In the real world, we face uncertainty related to projects, where there are no historical data, hence, we should rely on the experts' judgements to estimate activity durations. For this purpose, in this paper, the 99-simulation method is used to deal with uncertainty. The exact mathematical programming model is presented in this paper and the hybrid algorithm based on Genetic Algorithm is used to solve this type of project scheduling problem which finds the near-optimal solution in a short computational time. Finally, the effectiveness of the proposed model is examined with a numerical example. © 2020 by the authors; licensee Growing Science, Canada.


Vehicular crowdsourcing networks (VCNs) enable vehicles to provide or obtain traffic-related services in a costefficient and flexible manner. Therefore, it is crucial to provide trusted management in VCNs for high reliability towards both service producers and consumers. However, most recent VCN platforms rely on a third party to manage crowdsourcing services which might be not fully trusted by users. For the issue, this paper proposes a blockchain-based trust management scheme for VCNs to provide a decentralized and trusted service management. A comprehensive trust evaluation model (TEM) is designed to quantify the trust degree of each vehicular node, and a vehicle-trust blockchain framework called VTchain is proposed to preserve the trust values of nodes while guaranteeing transparency and trustworthiness. Particularly, we leverage a trusted execution environment (TEE) to provide secure trust evaluation to tackle possible untrusted road-side units. In addition, we introduce TEM-based Proof of Trust to support blockchain maintenance, which works together with an efficient consensus algorithm Zyzzyva for improved scalability. Finally, extensive experiments are conducted by developing a testbed deployed on cloud servers for measurements.


The Introductory Essay asks readers to consider four vignettes—on prostitution, Muslim women's dress, abortion, and Marine Le Pen. The vignettes illustrate what the authors term the poverty of women's political representation, representational problematics experienced by women in established democracies. These are also core issues identified in contemporary gender and politics research: of women's ideological and intersectional differences, skewed political and parliamentary agendas, and disconnect from political parties and electoral politics. The vignettes adopt a dialogical style to clarify and magnify core concerns of the book, highlighting the contemporary relevance and importance of the book to academic scholarship and democratic practice. The discussion of the vignettes weaves through reflection on "representation as it should be," what women's good representation might be. There would be significant change to political institutions, political representatives, political parties, and parliaments; elected representatives would be institutionally and systemically required to represent women.


PURPOSE
This observational study was based on a series of clinical cases in which failure of sinus augmentations occurred in patients who received prophylactic clindamycin therapy.

MATERIALS AND METHODS
Between the years 2006 and 2010, a retrospective observational study was performed. The study consisted of 1,874 patients (723 males and 1,151 females) in whom sinus augmentations were performed prior to placement of dental implants.

RESULTS
In nine (0.48%) patients (four males and five females), infection of the graft material inside the sinus floor occurred, and six patients developed an abscess in the site of surgery, 4 to 6 weeks postoperatively. In three patients, a buccal fistula with pus draining was observed 5 to 8 weeks postoperatively. In all patients, the source of infection was from the grafted material within the sinus. A common manifestation in all nine patients was that they had self-reported penicillin allergy and had been prescribed clindamycin (300 mg every 6 hours for 10 days).

CONCLUSION
Prophylactic clindamycin therapy following sinus augmentation procedures seems to be a risk factor for infections and loss of grafting material following these surgical techniques.


The dynamics of carrier recombination in proton bombarded high‐quality single crystal thin films of InAs grown by molecular beam epitaxy on transparent GaAs substrates are studied using the picosecond pump‐probe technique in the photon energy range 335–483 meV. The effects of extrinsic recombination at the InAs/GaAs interface and of point defects introduced by proton damaging are separated by studying samples ranging from 3.3 to 0.27 μm in thickness and with proton doses in the range 1011–1015 cm−2. The data indicate an interfacial recombination velocity of 2.7×104 cm s−1 and a defect capture time of 160 ps, and in the regime studied mobility limitations are found to have a negligible effect on the recombination dynamics.


In May 2011, the U.S. Library of Congress (LC) unveiled the National Jukebox, "the largest collection of historical recordings ever made publicly available online." The collaboration resulting in the Jukebox began in 2008, when Sony Music Entertainment granted LC a gratis license to digitize and stream its catalog of pre-1925 acoustical recordings from Victor Talking Machine Company, Columbia, Okeh, and other labels that it owns. LC staff and volunteers spent much of 2010 selecting 78s to digitize and add to the database. At its launch, the Jukebox includes more than 10,000 items from the Victor Talking Machine Company that were recorded between 1901 and 1925, with others to be added regularly from Columbia and Okeh. A Web browser, an internet connection, and a device with Adobe Flash installed are required; content streams freely with no login required, but downloads are not available. The Jukebox offers a diverse range of treasures from musical genres including blues, ragtime, classical, opera, and more. Important early jazz recordings await discovery, such as those of Lena Wilson singing "T'aint Nobody's Biz-ness If I Do" (1923) and the Original Dixieland Jazz Band's recording of "Livery Stable Blues." A large collection of Paul Whiteman Orchestra recordings is available, including the famous "Rhapsody in Blue," with Gershwin himself as the featured soloist. Opera enthusiasts will take pleasure in sides from Enrico Caruso, Nellie Melba, and dozens of others. Yet, there are also recordings that offer a special glimpse into the less familiar musical interests of early twentieth-century America. For example, listeners will find albums of whistling and yodeling, as well as novelty songs meant to tickle the listener's ears, like the aptly titled "Cat Duet" (1908). There is also ethnic music in Spanish, Swedish, Norwegian, Croatian, and several other languages/ethnicities. Finally, the Jukebox provides a snapshot of American history by providing spoken-word recordings and speeches. Listeners may access political speeches by Theodore Roosevelt, Woodrow Wilson, and William Taft, as well as poem recitations and Bible readings. One memorable recording features sound effects of snoring and sneezing. Users can access recordings by navigating to the Web site. Near the top of the home page, a single keyword search box is provided; patrons can


halothane, and oxygen. The operation and anaesthesia were uneventful. Subsequent pain was controlled by the injection of a further 50 mg pethidine. The next day she had only slight pain, which was well controlled by 30 mg doses of dihydrocodeine by mouth. On the second postoperative day, however, she became progressively drowsy with respiratory frequency slowing to four breaths/min. Her pulse became irregular with electrocardiographic evidence of ectopic beats and right bundle-branch block. She had no focal neurological signs, but her conscious level continued to deteriorate until she responded only to painful stimuli. Computed tomography of the brain showed no abnormality apart from carotid syphon calcification. Urine output was poor and plasma urea and creatinine concentrations rose to 14 5 mmol/l (87 mg/100 ml) and 250 ,tmol/l (2-8 mg/100 ml) respectively despite apparently normal hydration (plasma sodium concentration 133 mmol(mEq)/l). Arterial blood gas analysis showed oxygen tension 7 9 kPa (59 mm Hg) and carbon dioxide tension 6-5 kPa (49 mm Hg); she was treated with an inspired oxygen concentration of 35 % and her arterial tension rose to 12 3 kPa (92 mm Hg). Her slow, deep breathing suggested opioid overdosage, and 0 4 mg of the opioid antagonist naloxone was given intravenously. She immediately woke and asked where she was, and respiratory frequency increased to 20 breaths/min. She became sleepy again over the next half hour, her respiratory frequency falling to 10/min. A further dose of naloxone had a good but less dramatic effect. An infusion of doxapram was almost completely ineffective; she took only six breaths/min and remained drowsy. Lumbar puncture was performed; the pressure and appearance of the fluid were normal and a sample was taken for analysis. A continuous naloxone infusion was then started. As long as her respiratory frequency was greater than 10/min her conscious level remained satisfactory. The figure shows the respiratory frequency and doses of drugs used. The infusion was stopped on her sixth day in hospital; respiratory frequency fell but she no longer lapsed into unconsciousness. The respiratory rate was normal by the next day. For a few days after operation she was distinctly oliguric: this improved gradually with frusemide and fluid management.


See related article, pp 85–93

Failure to achieve blood pressure control represents a common finding in hypertensive patients treated at clinical practice level, the number of those in whom blood pressure values are reduced to 15% to 20% of the patients diagnosed as having a blood pressure elevation and no >30% of those placed under antihypertensive drug treatment.3,4 Blood pressure control does not seem to be better (it may indeed be worse) if out-of-office blood pressure is considered as the target for the therapeutic intervention. It is definitively much worse if lower blood pressure targets represent the treatment goal, as it has sometimes been advocated for diabetes mellitus, a high cardiovascular risk condition, or chronic kidney disease, at which the percentage of patients with blood pressure control may dramatically fall. Years of research have clarified that deficiencies of healthcare systems, physicians' failure to react with appropriate treatment changes to an uncontrolled blood pressure status (therapeutic inertia), low adherence to the prescribed drugs, and the limited use of drug combinations all heavily contribute to this situation,4 which may importantly depend, however, also on another factor. Namely, that blood pressure control may not be easily achievable even when optimal treatment is used, as exemplified by the frequent inability to meet this goal also in randomized trials despite large use of combination treatment and environmental conditions that minimize therapeutic inertia and maximize treatment adherence (Figure).5 This means that to more successfully manage the hypertensive population, more effective therapies are …


The title complex ([SmN(CH 2COO) 3(H 2O) 2]·H 2O, M r =392.52) has been prepared from Sm(ClO 4) 3 and NH 2(CH 2COO) 3Na in aqueous solution. The crystal structure of the complex was determined by X ray diffraction method. The crystal belongs to the orthorhombic system with space group Pbca, a=8.110(1), b=13\^120(2), c=20.788(2) , V=2211.9(5)  3, Z=8, F(000)=1512, μ =5\^349 mm -1 , R =0.0182 and wR =0.0385 for 1909 observed reflections with I2σ(I) . The Sm 3+ is nine coordinated and the coordination polyhedron is a distorted, tricapped trigonal prism. The whole structure can be characterized as a two dimensional network.


Automatic road detection from remote sensing images is a vital application for traffic management, urban planning, and disaster management. The presence of occlusions like shadows of buildings, trees, and flyovers in high-resolution images and miss-classifications in databases create obstacles in the road detection task. Therefore, an automatic road detection system is required to detect roads in the presence of occlusions. This paper presents a deep convolutional neural network to address the problem of road detection, consisting of an encoder-decoder architecture. The architecture contains a U-Network with residual blocks. U-Network allows the transfer of low-level features to the high-level, helping the network to learn low-level details. Residual blocks help maintain the network's training performance, which may deteriorate due to a deep network. The encoder and decoder structures generate a feature map and classify pixels into road and non-road classes, respectively. Experimentation was performed on the Massachusetts road dataset. The results showed that the proposed model gave better accuracy than current state-of-the-art methods.


Aspect level sentiment classification aims to identify the sentiment expressed towards an aspect given a context sentence. Previous neural network based methods largely ignore the syntax structure in one sentence. In this paper, we propose a novel target-dependent graph attention network (TD-GAT) for aspect level sentiment classification, which explicitly utilizes the dependency relationship among words. Using the dependency graph, it propagates sentiment features directly from the syntactic context of an aspect target. In our experiments, we show our method outperforms multiple baselines with GloVe embeddings. We also demonstrate that using BERT representations further substantially boosts the performance.


China advanced strategic decisions to build the first class university in the world in 1990's,which resulted the advancement of higher education. In such background,reviewing the development about the idea of university,linking the progress of the higher education of China, we can find out the shortage of building the first class university,and so some suggestions from the angle of the idea of university,should be attended to when build the first class university in China.


The lumped parameter/complex plane analysis technique revealed several contributions to the terminal admittance of the ZnO—Bi2O3 based varistor grain-boundary ac response. The terminal capacitance has been elucidated via the multiple trapping phenomena, a barrier layer polarization, and a resonance effect in the frequency range 10−2≤f≤ 109 Hz. The characterization of the trapping relaxation behavior near ∼ 105 Hz (∼ 10−6 s) provided a better understanding of a previously reported loss-peak. The possible nonuniformity in this trapping activity associated with its conductance term observed via the depression angle of a semicircular relaxation in the complex capacitance (C*) plane has been postulated.


This study aims to develop a proficient and clinically applicable algorithm that can accurately assess bone age. This algorithm is based on the principles of the Tanner‐Whitehouse 3 (TW3) integral approach, and aims to achieve efficiency, scalability, and interpretability. We developed a model for bone age prediction in children. The model was tested on a pediatric dataset from a tertiary care hospital consisting of left‐hand radiographs of children between the age of 0 and 18. Our model consists of removing the arm portion using a pre‐trained YOLO network, localizing 37 key points in the hand bone portion using a spatial configuration network, and segmenting the original image through 20 of these points to obtain 20 fixed‐size patches. Finally, each of the 20 bone images is classified by training a visual transformer (ViT) model. In this study, a hybrid network, SVTNet, was developed that incorporates visual transformers to obtain estimates of bone age in the carpal (C series) and metacarpal (RUS series) bones. The sum of the clinical TW3 scoring region scores and bone maturity scores were utilized to determine the bone age for each corresponding region. The performance of the algorithm was evaluated in terms of both training and testing by evaluating 3871 left hand X‐ray micrographs obtained from a tertiary hospital in China. The results showed that the average absolute error of bone age estimation was 0.50 years for the RUS series of bones and 0.47 years for the C series of bones. The main contribution of this study is to propose, for the first time, a ViT‐based bone age assessment method that automates the entire process of the TW3 algorithm and is clinically interpretable, with predictive accuracy comparable to that of an experienced orthopedic surgeon.


Has designed a tool that serves to maintain the plant to grow well. Plants that grow well in need of treatment were quite good, especially in maintaining soil moisture. So that the land remains under inert conditions in accordance with the standard requirements necessary plants enough water. For that need attention regularly for watering plants. The automatic Plant Watering prototype uses temperature sensors and inertial-based Microcontroller Arduino Uno can be used in the treatment plant without the need to set watering schedules. In order for watering is not carried out during the day or during the scorching sun, the temperature sensor is used. Arduino microcontroller pin which has 14 digital input/output, which serves as the center of the brain process or the automatic sprinklers. The system was designed using a motor driver to drive the motor to pump water watering. Watering can prototype uses temperature sensors and inertial-based microcontroller Arduino Uno to move in automation tools for soil moisture has not been reached. If the soil moisture has been reached then the pump will stop watering the plants.


In the fall of 2008, the financial crisis crushed the U.S. economy and plunged the country into the Great Recession. The crisis shuttered American businesses, cost millions of Americans their jobs, and wiped out home values and household savings. The macro effects hit hardest and were the longest


We analysed the adjuvant effect of Gantrez nanoparticles NP on oral immunisation of pigs and mice with F4 fimbriae. The animals were vaccinated with F4, F4 encapsulated in Gantrez NP, called gF4 NP, or F4 + empty Gantrez NP, called F4 + gNP, and intragastrically infected with F4+ ETEC. The adjuvant effect of Gantrez®AN nanoparticles on oral vaccination of pigs and mice with F4 fimbriae is strongly influenced by polymer degradation.


The Pre-Cambrian rocks of the Black Hills consist of a great series of slates and schists, for the most part monotonously alike, striking in a northwest direction and having steep dips generally, except in the extreme southwest, to the east. Close study shows that the persistent east-ward dips represent both schistosity and bedding, the two for the most part parallel; and that the series is compressed into a number of great folds which comprise innumerable minor isoclinal folds. A sufficient number of individual beds have been traced to locate the position and nature of the greater axes of folding, and to locate two important faults.


Summary Statement Help Received Debra C. Chang Effects of Solution Composition on the Stability of Antibubbles S0503 Objectives/Goals The purpose of this study was to determine the effects of solution compositions on the stability of antibubbles by examining size and lifespan. This project is the result of experimentation of nozzle sizes, polymer additives from varying liquids, and salt concentrations. Methods/Materials The stability of antibubbles was determined by means of injecting a liquid mixture of detergent and water into a specified solution, creating a pocket of liquid enclosed by a thin air film. The nozzle size experiment involved changing the diameter size of the jet stream injecting device from 3.0 mm (control), 2.0 mm and 1.2 mm. 10 mL of liquids, namely egg whites, honey and corn syrup, were added to the base solution to determine the effects of varying polymer additives. Lastly, salt concentrations were varied at 0.000945 g/ mL, 0.0025 g/mL, 0.0050 g/mL and 0.010 g/mL to determine their effects on antibubble stability. Results Results in the trials revealed that smaller nozzle sizes had lower diameters. The antibubbles from polymer additives also resulted in lower life spans compared to the control group. Lastly, the smallest salt concentration ended with the highest antibubble duration and diameter size. Conclusions/Discussion This project indicates that a decrease in nozzle sizes and addition of polymer additives lower durations and diameters. Also, an increase in salt concentration actually decreases the stability of antibubbles. The contributions of this project form a basis for future attempts to understand the mechanisms of antibubble formation and collapse to eventually create micron sized antibubbles for practical uses. My study presents the effects of nozzle sizes, polymer additives, and salt concentrations on antibubble stability and contributes towards future research on the practical uses of antibubbles. Borrowed basic lab equipment from Dr. Wenji Chang


Background:  Demonstration of the usefulness of Fournier's gangrene severity index in the management of Fournier's gangrene. Methods: A retrospective study of all the patients admitted to the hospital with Fournier's gangrene was included in the study in the year 2012. Fournier's gangrene was diagnosed by history and clinical examination.  Details of the patients were obtained from the hospital register. FGSI was calculated using 9 parameters; heart rate, temperature, respiratory rate, sodium, potassium, serum creatinine, serum bicarbonate, leukocyte count and hematocrit. The score was graded 0±4. Results:  The details of the patients were tabulated. The age of the patients ranged from 25 to 60 years (mean 44 years). All were male patients. The mean duration of disease before treatment was 7.5 days (ranged from 5 to 10 days). Three patients had diabetes and other patients did not have any risk factors. One among the diabetic was obese. Six patients had infection of scrotum and one patient had infection in with scrotal abscess needed I and D. Tissue and pus was sent for culture and sensitivity. Appropriate antibiotics were started covering aerobic and anaerobic organisms. Few patients required repeated debridement to minimize burden of infection. Antibiotics were changed according to culture sensitivity report. With repeated debridement and antibiotics, wound epithelized to surface. Secondary suturing was done as a corrective procedure to close the defect in 6 patients and split skin grafting was done in one patient as the defect was larger in size. FGSI was calculated in all patients. Five patients presented with necrotic patch, progressing rapidly needed necrosectomy initially and other patient presented treatment lasted for average of 45 days ranging from 38 to 55 days. All patients were cured with no mortality. Conclusions:  Necrotizing fasciitis of the perineum and genitalia is a severe and rapidly progressive condition with considerable morbidity and mortality. Survival can be improved in a patient with Fournier's gangrene by FGSI, aggressive surgical and medical management. FGSI is very useful in assessing the severity of the disease and high mortality associated with it. Continuous monitoring of all the parameters is essential for a good outcome, therefore reducing the high, mortality and morbidity of the condition.


Abstract Four‐year‐old 'Aki Fuji' apple trees in their second leaf of fruiting were used to study the influence of paclobutrazol on photosynthesis rate (Pn) and the partitioning of dry matter in the different parts of the tree. It was found that the Pn of paclobutrazol‐treated trees was significantly higher than the untreated check trees. This is partially accounted for by the higher light intensity in the canopy of the paclobutrazol‐treated trees. Production efficiency of the paclobutrazol‐treated trees was 2.6 times higher than that of the untreated check trees. Paclobutrazol significantly changed the partitioning pattern of dry matter in the different parts of the tree. A much higher percentage of total dry matter was distributed to the fruit. However, a higher percentage of dry matter was found in the root of the paclobutrazol‐treated trees than in the untreated trees, the difference being mainly in the lateral and fibrous roots. Total dry matter accumulated per m2 of occupied land of the paclobutrazo...


A novel dual-band microstrip bandstop filter with multiple poles using open/shorted coupled lines is proposed in this paper. Nine transmission poles near the two stopbands can be easily realized by conventional coupled lines and transmission lines. The two center frequencies of the dual-band bandstop filter can be adjusted flexibly by only changing the even/odd-mode of the coupled lines. The planar microstrip dual-band bandstop filter (<inline-formula> <tex-math notation="LaTeX">$\varepsilon r = 2.65$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$h = 0.5$ </tex-math></inline-formula> mm) with nine transmission poles is designed and fabricated. High selectivity and good in-band performances can be achieved in the proposed filter.


Most depictions of the Orpheus story privilege the moments that musicians like best. Typically, he stands with his mouth wide open in song, strumming his lyre, taming the wild beasts, and charming even the trees. Bernard Salomon's emblems that in 1557 reduced the Metamorphoses to a collection of 178 woodcuts with brief summaries are no exception (see fig. 1). The text instructs viewers to take note of Orpheus's fabulous skill at singing and playing. This mirrors what has long been assumed to be the take-home message of Claudio Monteverdi and Alessandro Striggio's L'Orfeo. Ovid's version, however, paints a more complex picture; despite his musical charms, Orpheus meets an unseemly end when the bacchantes tear him to bits:


The students of P.E.department of teachers' college ,must attach importance and strengthen the ability of judgment ,in order to raising their ability and making them become qualified judgments .It's important to promote the P.E. cause of basic level.


An important dairy basin located in the region of Agreste of Pernambuco, maintains the tradition in the production of milk and derivatives, having in the cream a lipid food of great sensorial appreciation. However, its artisanal production can compromise the physical-chemical and hygienic-sanitary quality. Therefore, this study aimed to evaluate the microbiological parameters and the centesimal composition of the cream produced in the Agreste of Pernambuco. Total coliforms at the mean concentration of 4.0 x 102 CFU.g-1 and thermotolerant coliforms up to 20 CFU.g-1 were found, the latter in a concentration above the limit allowed by RDC No. 12 (BRASIL, 2001). the amount of up to 10 CFU.g-1, thus proving the presence of fecal material next to the product. The presence of coagulase positive Staphylococcus and Salmonella spp. The centesimal composition of the cream showed 531.07 kcal, 39.39% humidity, 0.26 g ash, 0.92 g of carbohydrate, 1.7 g of protein, and 57.73 g of lipids. Considering the microbiological results and the centesimal composition, it is observed that the cream studied should be consumed with moderation, since besides presenting a high percentage of lipids, above the nutritional recommendation, that is up to 30%, it is unsafe as to its consumption, due to the presence of thermotolerant coliforms above the limit allowed by current sanitary legislation.


The Real-Time Internet Peering for Telephony (RIPT) protocol defines a
technique for establishing, terminating and otherwise managing calls
between entities in differing administrative domains. While it can be
used for single user devices like an IP phone, it requires the IP
phone to have TLS certificates and be publically reachable with a DNS
record. This specification remedies this by extending RIPP to enable
clients to receive inbound calls. It also provides basic single-user
features such as forking, call push and pull, third-party call
controls, and call appearances. It describes techniques for resiliency
of calls, especially for mobile clients with spotty network
connectivity.


© Author(s) (or their employer(s)) 2022. Reuse permitted under CC BYNC. No commercial reuse. See rights and permissions. Published by BMJ. InTroduCTIon Although the content of one's consciousness changes through time (eg, personality changes), their identity or psychological continuity still, somehow, remains the same. In fact, typical human selfcontinuity—the unity of consciousness over time—spreads out over a period of hours, from one episode of dreamless sleep to a waking state. I wake up, eat breakfast, take a shower, get dressed, go to the institute and start the routine work of my scientific life. I am conscious the whole time, and the experiences I have at each phase of my morning, belong to a single stream of consciousness. However, this smooth subjective occurrence of self does not function for some people. In some patients, like those with schizophrenia, selfcontinuity abruptly ceases. They experience a kind of divorce from reality with various behavioural disturbances such as hallucinations, delusions and catatonia. In practice, the patient experiences a weird sense of losing their identity. It seems that they are unable to preserve their identify of self with the outside world. In other words, they lose contact with the reality of the world. There is also a large body of literature suggesting that those with schizophrenia turn away from the outside world and become concerned with their own subjective state. By a closer look at some of the thought disorders of schizophrenia, we notice that a metaphoric glue in the stream of consciousness is missing. This includes derailment or tangentiality or knight's move thinking—a failure to follow the social norms of conversation and not sticking to the overall theme of the discussion, or pressure of speech— a speeding up of the flow of speech. Besides, there is evidence indicating that their perception of the world differs qualitatively from that of a normal individual; this, in consequence, leads to a deprivation in their gratitude towards the outside world. This is exactly the point which we should notice more. Why do they lose contact with the outside world? What happens inside the minds of these individuals that makes them disconnected? Is it just neurodegeneration in a region of the brain (such as in Alzheimer's) or lack of a special kind of neurotransmitter (such as in Parkinson's disease)? Or, is it only a genetic problem? Although many research institutions that investigate the aetiology of schizophrenia have concentrated on organic deficits, they are unable to reach a consensus on why these people lose their thread of self. Before answering these questions, one of the main locomotion theories after the dawn of the cognitive revolution in the mid20th century—the reafference principle (von Holst and Mittelstaedt)—should be reviewed. One may presume that the answer to these questions lies within a better understanding of this theory.


Infrequent sampling of precipitation in Florida has been conducted by the U.S. Geological Survey since 1965. A summary of the historical data from 24 sites throughout Florida indicate that the principal ionic composition of atmospheric precipitation samples is calcium sodium and bicarbonate chloride with an average specific conductance of 32 micromhos per centimeter at 25°C. Historically, much of the sampling focused on primary nutrients and selected trace elements. Historical data indicate that nitrogen and phosphorus concentrations averaged 1.1 and 0.1 milligrams per liter, respectively. The limited trace metal data indicate that motor-vehicle activity may have a significant impact on local precipitation quality. Lead, for example, was measured in concentrations of as much as 2,400 micrograms per liter in samples collected in a highly populated, commercial area in south Florida. Statistical testing indicated that most major inorganic constituents, primary nutrients, and trace metals were significantly different among the sampling sites. The pH data indicated a range of about 5.0 to 7.0, but only limited pH data were collected and analyzed at the historical sites in such a timely manner as to represent pH conditions of the atmospheric precipitation during active rainfall. A critical review of the historical data suggested that while they may reflect local atmospheric quality conditions they likely do not define baseline conditions from a regional perspective. The application of these data was limited regarding regional extrapolation due to variations in sampling techniques, methods of sample preservation, sampling intervals, sample sizes, and periods of record.


encountered in concert halls and stadiums throughout Latin America" (Gienow-Hecht: p. 152). Of course, the United States learnt to exploit this distinction to great effect during the cold war, as is attested by Emily Ambrams Ansari's fascinating essay on soft power, "Music Diplomacy in the Emergency: Eisenhower's 'Secret Weapon,' Iceland, 1954–59." So the mere fact that musical practice can introduce an internal distinction into political life is not a default cause for optimism. However, exposure to the strange slipperiness of music within the global context nevertheless presents us with a much-needed reminder that there are limits to the degree of politics' colonization of discursive space, and that one of the things that has most effectively set up residence at such limit points is music, in all its strange political and ethical ambiguity.


The development and management of a right-ofway is a complex process which must consider the ecological and social implications of the resulting severance on plants, animals and people, as well as the benefits which will accrue to the utility and society. Management policies must be based on sound ecological and economic practices that provide the required degree of line security as well as other benefits to society.


ABSTRACT The single-chain fragment variable (scFv) was used to produce a completely functional antigen-binding fragment in bacterial systems. The advancements in antibody engineering have simplified the method of producing Fv fragments and made it more efficient and generally relevant. In a previous study, the scFv anti HIV-1 P17 protein was produced by a batch production system, optimized by the sequential simplex optimization method. This study continued that work in order to enhance secreted scFv production by fed-batch cultivation, which supported high volumetric productivity and provided a large amount of scFvs for diagnostic and therapeutic research. The developments in cell culture media and process parameter settings were required to realize the maximum production of cells. This study investigated the combined optimization methods, Plackett–Burman design (PBD) and sequential simplex optimization, with the aim of optimize feed medium. Fed-batch cultivation with an optimal feeding rate was determined. The result demonstrated that a 20-mL/hr feeding rate of the optimized medium can increase cell growth, total protein production, and scFv anti-p17 activity by 4.43, 1.48, and 6.5 times more than batch cultivation, respectively. The combined optimization method demonstrated novel power tools for the optimization strategy of multiparameter experiments.


NASA's Synthetic Vision Systems (SVS) project is developing technologies with practical applications to eliminate low visibility conditions as a causal factor to civil aircraft accidents while replicating the operational benefits of clear day flight operations, regardless of the actual outside visibility condition. A major thrust of the SVS project involves the development/demonstration of affordable, certifiable display configurations that provide intuitive out-the-window terrain and obstacle information with advanced pathway guidance for transport aircraft. The SVS concept being developed at NASA encompasses the integration of tactical and strategic Synthetic Vision Display Concepts (SVDC) with Runway Incursion Prevention System (RIPS) alerting and display concepts, real-time terrain database integrity monitoring equipment (DIME), and Enhanced Vision Systems (EVS) and/or improved Weather Radar for real-time object detection and database integrity monitoring. A flight test evaluation was jointly conducted (in July and August 2004) by NASA Langley Research Center and an industry partner team under NASA's Aviation Safety and Security, Synthetic Vision System project. A Gulfstream G-V aircraft was flown over a 3-week period in the Reno/Tahoe International Airport (NV) local area and an additional 3-week period in the Wallops Flight Facility (VA) local area to evaluate integrated Synthetic Vision System concepts. The enabling technologies (RIPS, EVS and DIME) were integrated into the larger SVS concept design. This paper presents experimental methods and the high level results of this flight test.


AIM: This study was conducted to know the factors associated with acceptability of immediate post placental IUCD insertion in women and to know the level of safety efficacy and expulsion of post placental insertion of IUCD. MATERIAL AND METHODS: This study was conducted in Obstetrics and Gynaecology, Department of Gandhi Memorial Hospital, Rewa (M. P.) over period of 9 months. Women admitted and delivered at SGMH were counseled regarding IUCD like its advantage side effects and complications. CuT 380A was inserted within 15 minutes of delivery of placenta and membranes in women who had no contraindication for post placental IUCD and gave consent for this. All these women were followed up to 6 months post insertion period. RESULTS: Total number of counseled women was 600 over the period of three months from August 2014 to October 2014. Out of these only 400 women gave consent for PPIUCD insertion, 200 denied. 100 Lost follow-up only 300 women were followed-up. Among followed-up women 30 women had expulsion, 20 women had only bleeding problem, 20 women had only pain in abdomen, bleeding and abdominal pain together in found in 60 women, thread problem in 5 women and continuation on contraceptive method by 230 women, 70 women discontinued IUD because of bleeding, pain in abdomen, missing thread, family pressure etc. CONCLUSION: On the basis of our results it may be concluded that insertion of CuT 380A within 15 minutes after placental delivery has high retention rate, expulsion rate was not very high and it can be reduce with practice. Acceptability of this contraceptive method is high with proper counseling despite of low awareness level.


Using video observation,etc.,the authors analyzes four aspects systematically:the ball possession in fore field,middle field and back field,the number of shoots,the shoot successive rate and the number of goals.They discuss the related factors on influencing the competition victory or defeat taking the ball possession and the shoot successive rate as a point of penetration.The results show that there is a prominent positive pertinence between ball possession in the fore field and the number of shoots and a prominent negative pertinence between the shoot successive rate and the number of losing balls and that there is no prominent pertinence with the number of goals.There is a prominent positive pertinence between ball possession in the middle field and the number of shoots,the number of goals and attacking efficiency,and a prominent positive pertinence with the number of shoots.There is the most prominent positive pertinence among ball possession in the back field,middle field and back field,and no prominent pertinence with others.


Three of the most fundamental changes in US corporations since the early 1970s have been (1) the apparent increase in the importance of organizational capital in production, (2) the increase in managerial income inequality and pay-performance sensitivity and (3) the secular decrease in labor market reallocation. Our paper develops a simple explanation for these changes: a shift in the composition of productivity growth away from vintage-specific to general growth, brought about by the arrival and gradual adoption of information technology since the 1970s. This shift has stimulated the accumulation of organizational capital in existing firms and reduced the need for reallocating workers to new firms. We characterize the optimal managerial compensation contract when firms accumulate organizational capital but risk-averse managers cannot commit to staying in the match. A calibrated version of the model reproduces the increase in managerial compensation inequality and the increased sensitivity of pay to performance in the data over the last three decades. In addition, we show that firms in industries with less vintage-specific growth and hence more more compensation inequality have higher Tobin's q, as predicted by our model. ∗We are grateful to Jason Faberman, Carola Frydman, Enrichetta Ravina, and Scott Schuh for generously sharing their data with us. Lorenzo Naranjo and Andrew Hollenhurst provided outstanding research assistance. For helpful comments we would like to thank Andy Atkeson, Jonathan Berk, Nick Bloom, Murray Carlson, Xavier Gabaix, Ron Giammarino, Fatih Guvenen, Hugo Hopenhayn, Boyan Jovanovic, Adriano Rampini, Kjetil Storesletten, and participants at the UCL conference on income and consumption inequality, the NBER Asset Pricing meetings in Cambridge, the Western Finance Association in Hawaii, Society for Economic Dynamics in Cambridge, the CEPR conference in Gerzensee, and seminar participants at Duke finance, NYU Stern finance, HBS finance, UBC finance, Wharton finance, Stanford Economics and the NYU macro lunch. This work is supported by the National Science Foundation under Grant No 0550910.


Motivated by $\ell_p$-optimization arising from sparse optimization, high dimensional data analytics and statistics, this paper studies sparse properties of a wide range of $p$-norm based optimization problems with $p > 1$, including generalized basis pursuit, basis pursuit denoising, ridge regression, and elastic net. It is well known that when $p > 1$, these optimization problems lead to less sparse solutions. However, the quantitative characterization of the adverse sparse properties is not available. In this paper, by exploiting optimization and matrix analysis techniques, we give a systematic treatment of a broad class of $p$-norm based optimization problems for a general $p > 1$ and show that optimal solutions to these problems attain full support, and thus have the least sparsity, for almost all measurement matrices and measurement vectors. Comparison to $\ell_p$-optimization with $0 < p \le 1$ and implications to robustness are also given. These results shed light on analysis and computation of general $p$-norm based optimization problems in various applications.


This article identifies a semantically motivated typology of lexicalization paths to account for the formation of nominal compounds from complex noun phrases. The typology includes coordination, semantic roles and possession, which, systematically, seems to be the origin of various subclasses of appositional, copulative and endocentric compounds, and the typology has serious implications for linguistic theory.


In 1981 at the Festschrift honoring the many contributions of David W. Smith, I presented a unique pair of siblings with a distinctive pattern of malformation. The paper from this presentation was published as part of a series in the Journal of Pediatrics [Carey et al., 1982], and this condition has come to be called the Carey–Fineman–Ziter syndrome (CFZ). The described disorder included the following components: facial diplegia with an opthalmoplegia comprising the Moebius sequence, the Pierre Robin sequence, short stature, postnatal-onset microcephaly, congenital and persistent hypotonia, brachydactyly with absent digital flexion creases, and a generalized muscular hypoplasia. The sibs, a male and female, showed normal intelligence, a characteristic face, and an apparent myopathy although no specific muscle disorder was recognized on biopsy. The family was described in the context of a review of the causes and pathogenesis of the Robin sequence [Carey et al., 1982]. In fact, the observation that these sibs had Pierre Robin sequence as a component of a generalized neuromuscular disorder lent support to the notion that the disruption of palatal closure could be due to altered jaw or tongue movement during early development (the so-called Robin complex as discussed by Cohen [1999]). The purpose of my Commentary here is to provide an update on the original patients in the context of the ensuing articles in this issue of theJournal [Dufke et al., 2004; Maheshwari et al., 2004; Verloes et al., 2004]. In addition, I will discuss the nosology of the Moebius sequence and its associated syndromes and propose two candidate genes as the potential basis of the CFZ syndrome. The overall significance of this disorder and its place in our understanding of the Moebius and Robin sequences will be addressed briefly. I have had the privilege of following the two original siblings with the CFZ syndrome since 1980. The original Patient 1 (Fig. 1) recently completed a 2 year mission for the Church of Jesus Christ of Latter Day Saints. Despite challenges in school related to hearing and verbal expression, the patient completed high school and is now enrolled in college. His medical problems since the original report have included longstanding GI disturbances related to biopsy-proven villous atrophy. Like his older sister, he has had significant scoliosis requiring surgery and placement of rods. At the time of this surgery at age 16 years, we performed a repeat muscle biopsy that again showed nonspecific findings and, in particular, there were no alterations of mitochondria. He continues to be in relatively good health and has not had the significant restrictive lung disease and pulmonary insufficiency that his older sister experienced. The original Patient 2, the older sib of Patient 1, is shown in updated photographs in Figures 2 and 3. She also had normal intelligence and finished junior college. She, however, did have significant restrictive lung disease and died of pneumonia at age 37. She also had rods placed for her scoliosis as a teenager. The physical examination of both patients was updated in 1996 when these most recent photographs were taken (Figs. 1 and 2). Note the consistent facial diplegia, but also the characteristic nasal configuration. Both had microcephaly and short stature (<2nd centile). Examination of hands showed absence of distal flexion creases on the 4th and 5th digits and brachydactyly. Both individuals had marked decrease in muscle mass and normal, but decreased, deep tendon reflexes.


The invention relates to non-fermentation type sour milk and a preparation method thereof. The non-fermentation type sour milk uses fresh cow milk as principal raw material. After being hydrolyzed by milk sugar, the cow milk is pasteurized and concentrated in vacuum to be 40 percent of the original volume. After the cow milk is cooled, probiotic powder is added. The invention has the core that transglutaminase is added at an optimal temperature; under the action of the transglutaminase, milk protein is connected together to form a protein network, thereby a uniform stable gelatin system is easily formed; delta-gluconolactone is then added, and the gelatin system and the delta-gluconolactone are heated at 35-40 DEG C in a water bath way for 2 to 3 hours so that the uniform, stable and exquisite non-fermentation type sour milk like a quark can be obtained. The invention has simple preparing process, no requirement for fermentation, and full utilization of resources. The non-fermentation type sour milk can be used as a base to develop various products, such as corn non-fermentation type sour milk for breakfast, jelly non-fermentation type sour milk, and the like, and can satisfy the requirements of consumers in nutrition, mouthfeel, texture, and the like.


Obesity increases significantly cancer risk in various organs. Although this has been recognized for decades, the mechanism through which this happens has never been explained. Here, we show that obese people (BMI ≥30) have on average 55% (95%CI: 46%-66%), 68% (95%CI: 59%-76%), and 39% (95%CI: 29%-49%) larger kidneys, liver, and pancreas, respectively. We also find a significant linear relationship between the increase in organ volume and the increase in cancer risk (P-value<10−12). These results provide a mechanism explaining why obese individuals have higher cancer risk in several organs: the larger the organ volume the more cells at risk of becoming cancerous. These findings are important for a better understanding of the effects that obesity has on cancer risk and, more generally, for the development of better preventive strategies to limit the mortality caused by obesity.


An accurate description of a sub-cycle pulsed beam is presented, which are exact solutions of Maxwell's equations, and applicable to a focused pulsed beam with a pulse duration down to and below one cycle.


1. Differences were found among eight populations of White Plymouth Rock pullets in the frequency of broken eggs. 2. The shells of such eggs were thinner than those of intact eggs in seven of the populations. 3. The number of defective eggs, the specific gravity of the eggs, and the percentage hen‐day egg production of normal eggs were significantly correlated within populations with the incidence of broken eggs. 4. No significant correlations were found within populations between the incidence of egg breakage and either egg weight, body weight, or shank length.


Based on real option theory,it studies expanded multiple real option model and reciprocity,describes the calculation of real option value with Monte Carlo simulation method.Firstly,it carries an expanded analysis based on Geske Model,introduces the holistic means to apply real option model in multiple investment.Then it analyzes the reciprocity of multiple real options to indicate that different real option has different influence to each other.Finally,a numerical analysis with Monte Carlo simulation shows that the input variable more actual and the output are easier to understand and recognize.


In maximally decimated filter banks, the perfect reconstruction or biorthogonal solution is not necessarily the best choice when subband quantizers are present. Under suitable statistical assumptions, expressions for the best synthesis bank can be derived in terms of the analysis bank and other statistical quantities. We explore this topic for subband coders and the special case of transform coders. We highlight the statistical conditions under which the biorthogonal solution is still the best. We derive expressions for the Wiener filter matrix in terms of the joint statistics of appropriate signals. Special cases where the optimal synthesis filter bank is the biorthogonal system followed by a scalar post filter are also considered.<<ETX>>


P-L. Khong, D. Qiu, A. Yung, G. Poon, C. Leung, S. Chua, G. McAlonan, B. Lam Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, Hong Kong, Paediatric and Adolescent Medicine, The University of Hong Kong, Hong Kong, Hong Kong, Hong Kong, The Duchess of Kent Children's Hospital, Hong Kong, Hong Kong, Hong Kong, Psychiatry, The University of Hong Kong, Hong Kong, Hong Kong, Hong Kong


A quadrature scheme is described for the calculation of the radiation field of an open-ended guiding structure directly from the longitudinal field components of the mode in the aperture. The calculated radiation pattern for a rectangular waveguide and a regular polygon dielectric rod agree well with known results. Radiation patterns for rectangular dielectric rod are also presented.


[reaction: see text] Arylsilanes were regioselectively labeled with deuterium by treatment with platinum(IV) oxide and deuterium oxide under hydrothermal conditions. Arylsilanols were also labeled with regioselectively under the same conditions.


notoriously short notice of Rome), and a similar nostalgia for the sanctiμed past is found in the allusions to watercourses and trees (the olive of Athens, the laurel of Antioch), which to fourth-century Gauls could have carried a similar charge. Side by side with this religious theme is that of 'l'uomo', meaning architecture and townplanning; this is indeed a prominent feature, often the result of observation. Ausonius is compared with Le Corbusier and other architects, and a few pages later he is credited with a tenuous rôle in the tradition of the tourist guidebook. A more interesting idea (this is the main item under 'Fortuna') is that this work in·uenced poems of Paulinus of Nola, including his nineteenth, with its re·ection on the sacred sites of Western Christendom. In the section on the manuscript tradition Di S. draws up useful lists of the errors of the various families, and of modern emendations. He discusses problematic passages at considerable length, with μfteen pages on the problem of adjudicating between the readings Hispalis and Emerita in l. 82. (One may not choose both, or label them as authorial variants.) One of the arguments for reading Hispalis was in fact anticipated by me in Actas del VIII Congreso Español de Estudios Clásicos (Madrid, 1994), II, pp. 679–83. Judging whether to admit modern emendations is a bigger problem. Far be it from the reviewer to laud his own remedy at l. 5; but the defence of ambarum that Di S. makes is not easy to understand, and perhaps familiarity breeds assent. However, at l. 91 the continued obelization is reasonable, notwithstanding interesting suggestions from Frassinetti (Graium) and Mondin (Cressas). The commentary is full, and concentrates on minor textual problems, on translation, on Ausonian usage, and on history and topography. With up to 1000 words per line of Latin, and full quotation of parallels and other passages, it should support the new reader well. On l. 148 and the lines that follow, English and French readers would beneμt from consulting the relevant chapter of P. J. Adam, La Construction Romaine, Matériaux et Techniques/Roman Buildings: Materials and Techniques (Paris, 1984/ London, 1994), to visualize the appearance and function of what is described, presumably a reservoir or castellum aquae as well as a fons. No fewer than eleven indexes (including ones on Economia e Commercio, Popoli, and Studiosi) attest the editor's great industry and the breadth of this study.


The gene encoding alkaline phosphatase was obtained by PCR from E. coli ATCC 25922, and the amplicon was inserted into the place which was between the sites of the restriction enzyme Bam HⅠ and XhoⅠ in prokaryotic expression vector pET-30a (+) to construct the recombinant pET-30a-EAP. This recombinant was transformed into E. coli RosettaTM(DE3) pLysS and then highly expressed by induction of 0.5 mmol·L-1 IPTG. The expressed protein EAP was mainly soluble, and SDS-PAGE analysis showed that its molecular weight was about 52 ku. This recombinant alkaline phosphatase was purified through affinity chromatography and the enzymatic activity analysis was carried out via pNPP chromogenic reaction and the dephosphorylated test. The results showed that this recombinant enzyme could catalyze the phosphate ester hydrolysis, and it possessed the advantages such as a high and heat stability, and a wide temperature range. The more important point was that this enzyme EAP from E. coli ATCC 25922 remained the normal enzymatic activity when fused with other proteins. The above results provided us a good reference basis for the large scale industrial production of alkaline phosphatase of E. coli ATCC 25922 and its application for the marker enzyme and reportergene of molecularbiology detection methods.


Abstract A brief discussion is given of thermal shock, erosion, and catastrophic corrosion problems connected with uncooled rocket nozzles used with solid fuels. This is followed by a description of materials and methods used to meet these problems. A small oxygen-hydrogen rocket motor was used to screen materials. Slip cast fused silica was used as a base material and erosion and corrosion resistance was provided in the throat area with arc-sprayed coatings or shells. Fabrication and evaluation techniques used are described as are forming methods and test results. 7.2


The purpose of the article was to present the functioning of logistics processes in the brewery. The
methods used in the article include an analysis of literature, participant observation and case study. The
data was collected during interviews conducted with the employees of one of the breweries belonging
to an international corporation. Based on the research identified the most important raw materials and
materials necessary for the production and distribution of beer. These include: water, malt, hops, yeast
and packaging. The article presents the organization of supplying the brewery with these products.


[Objective]To study the changes of intestinal flora and secretory IgA(sIgA)levels after the rectum resection.[Methods]Sixty patients diagnosed with colorectal cancer requiring the rectal resection were in observation group,while 60 healthy volunteers were in control group.The contents of stool intestinal flora and serum sIgA in each group were observed before and after the operation.[Results]After the operation,the contents of intestinal flora including bifidobacteria,lactobacilli,E.coli and enterococci were significantly lower than pre-operation.The contents of bifidobacteria and lactobacilli in the control group were higher than in the observation group,while the contents of E.coli and enterococci were lower than in the observation group.The levels of sIgA were of no significant difference after the operation.[Conclusion]The rectum resection may be followed by a syndrome of alteration of intestinal flora with reduced probiotics and elevated bacteria,leading to an impairment of intestinal barrier function.It's necessary to conduct probiotics treatment in order to rebuild the balance of intestinal flora and restore intestinal barrier function.


OBJECTIVE
To determine the risk of breast cancer in patients presenting with breast pain in Accra, Ghana.

DESIGN
Retrospective clinical study.

SETTING
A self-referral breast clinic in Accra, Ghana.

SUBJECTS
Patients with breast pain as a presenting complaint, between January 2001 and December 2005.

INTERVENTIONS
Patients were investigated by triple assessment.

RESULTS
There were 447 patients with pain, 322 as the only symptom and 125 in addition to other symptoms like breast lump and nipple discharge. Patients with pain only were found to have no detectable abnormality 203 (63%) and fibroadenosis 78 (24.2%) as the most common diagnoses. Breast cancer was found in four (1.24%) of them, all of whom had abnormality on clinical breast examination. In patients with pain as well as other symptoms the common diagnoses were fibroadenosis 25 (20%), breast cancer 20 (16%) and normal 18 (14.4%).

CONCLUSION
The risk of breast cancer is significantly higher in patients presenting with breast pain in addition to other symptoms, compared to patients with breast pain as the only symptom (16% and 1.24% respectively P < 0.0001). Patients with breast pain should always have breast examination and not simply reassured. Women should be encouraged to do breast self examination.


A-C. Volitional abduction and adduction of the toes becomes possible again in the SCI patient Nefeli. With the activation of the Mm. interrossei dorsales and plantares (C), the regeneration of the spinal cord has reached the S1 to S3 spinal cord segments.