With the aging trend of the first pregnancy and the younger onset of gynecological malignancies (cervical cancer, ovarian cancer, endometrial cancer), more and more young gynecological cancer patients have not completed their reproductive mission. On the other hand, with the maturation of early diagnosis and treatment of gynecological malignant tumors, the tumor survival rate has been greatly improved. How to choose a plan suitable for young gynecologic cancer patients to retain fertility without affecting the treatment of malignant tumors, so that their subsequent fertility aspirations can be realized, is a problem that clinicians need to consider when treating tumors, and is also a challenge for reproductive medicine. Combined with the stage of gynecologic malignant tumor, this article reviews the indications, surgical methods, the timing and follow-up of pregnancy after treatment, the methods of helping pregnancy, and how to deal with the recurrence of tumor after fertility preservation treatment, to provide guidance for clinical treatment.

Key words:
Gynecological malignant tumor; Tumor surgical treatment; Fertility preservation


Background There is conflicting data on the effect of the addition of ATRA to chemotherapy in AML. Two large randomised trials showed no benefit (Estey et al Blood 1999; 93, 2478 (n=215); Burnett et al. Blood 2010, 115: 9482 (n=1075)), or benefit which was limited to patients with an NPM1 mutation (n=14) when given in combination with ICE (Idarubicin/Ara-C/Etoposide) (Schlenk et al, Leukemia 2004, 18; 1798 (n=242)) but not with DA alone. In an effort to prospectively clarify if this is predictive treatment for NPM1+ patients and whether the effect was etoposide dependent, we randomised 616 patients to DA vs ADE and ATRA vs no ATRA in a 2x2 factorial design. Methods Between August 2010 and May 2012, 616 patients were randomised. The median age was 67(53-82) years: 75% had de novo, 16% had secondary, and 8% had high risk MDS (marrow blasts 10-19%): 4%, 75% and 21% had favourable, intermediate or poor risk cytogenetics: ITD and NPM1 data was available on 422 and 404 patients, with mutation rates of 19% and 24%. A total of 56 patients (14% of those with data) were molecularly good risk (NPM1 mutant, ITD wild type). By Wheatley risk score, 24%, 40% and 36% had good, standard or poor risk disease. The demographic, cytogenetic, molecular and allocated treatments were balanced between the arms. Follow-up is complete to 1st January 2013 (median follow-up 18.7 months) Patients were given Daunorubicin 50mg/m2 days 1-3 + Ara-C 100mg/m2 bid days 1-10 (course 1) or days 1-8 (course 2). Those allocated ATRA were treated at 45mg/m2/day for 60 days; Etoposide in the ADE arm was given at 100mg/m2/day on days 1-5 of courses 1 and 2 of chemotherapy. Results The overall response rate (ORR) was 69% (CR 53%+ CRi 16%) and survival at 2 years was 35%. The ORR was not different between DA: 68% (CR 53%, CRi 15%) and ADE: 70% (CR 53%, CRi 17%), odds ratio (OR) 0.92 (0.65-1.30) p=0.6, although remission rates were non-significantly lower in patients given ATRA (ORR 66% (CR 53%, CRi 13%) vs 73% (CR 54%, CRi 19%), OR 1.39 (0.98-1.95) p=0.06) with significantly higher 30-day (16% vs 8%, p=0.005) and 60-day mortality (20% vs 12%, p=0.005). There were no differences in early mortality between ADE and DA arms. At 2 years, neither survival nor RFS differed between the arms: (ADE vs DA OS: 33% vs 36%, HR 1.07 (0.86-1.32) p=0.6; RFS: 23% vs 36% HR 1.15 (0.88-1.49) p=0.3; ATRA vs Not OS: 35% vs 35% HR 1.13 (0.91-1.40) p=0.3; RFS: 31% vs 30% HR 0.93 (0.71-1.20) p=0.6). Overall there was no interaction between the two treatments (OS, test for heterogeneity p=0.12). In an analysis stratified by Etoposide and by NPM1/ITD risk group there was no significant heterogeneity of the effect of ATRA (p=0.1, Figure). Importantly, when looked at by the underlying chemotherapy, no beneficial effect of ATRA in NPM1 mutant/ITD WT patients appeared for patients receiving ADE (p=1.0 for heterogeneity). Conclusions Neither the addition of Etoposide nor ATRA improves outcomes in this group of patients, with ATRA being associated with significantly greater early mortality. Importantly, an analysis by NPM1/FLT3 genotype fails to reproduce the large benefits seen by Schlenk et al in ATRA treated patients with an NPM1 mutant/ITD wild type genotype, either overall or for patients treated with ADE, thus failing to substantiate a benefit for ATRA in either context. Based upon the results of AML16, neither Etoposide nor ATRA improve outcomes for older patients given intensive DA chemotherapy. Acknowledgements This study received research support from Cancer Research UK, and the Cardiff Experimental Cardiff Medicine Centre. Disclosures: No relevant conflicts of interest to declare.


The induced maturation and breeding of Penaeus monodon in captivity was first developed in India in seventies (Alikunhi et al 1977; Alikunhi and Hameed Ali 1977; Muthu and Laxminarayana 1977). With the later standardisation of hatchery systems with designs, feeding schedules etc., amenable for convenient operation, shrimp hatcheries started proliferating not only along the Indian coastline but also along the coastline of the countries of the sub-continent.


The article is devoted to the general study of the peculiarities of normative and legal regulation of pension provision in connection with the loss of the breadwinner in Ukraine and the determination of directions for improving the mechanism of pension provision of disabled persons in connection with the loss of the breadwinner on the basis of the analysis of the current legislation of Ukraine. The concept, content, conditions, size and essence of the pension in connection with the loss of the breadwinner, since state pension provision is one of the fundamental measures to ensure the rights and freedoms of a person and a citizen in Ukraine, is revealed. Statistical analysis of the number of persons receiving a pension in connection with the loss of breadwinner during 2018-2020 was conducted. A number of problematic issues related to the introduction of the electronic system - "Portal of electronic services of the Pension Fund of Ukraine", among them: ignorance of the elderly in modern technologies; «human factor» is connected with the inattention of employees of the Pension Fund of Ukraine on the transfer of information to electronic registers; the lack of modern serviceable technological resources in the departments of the Pension Fund of Ukraine; the risk of theft or distribution of personal data by third parties, hackers or other persons. It was established that the improvement of the mechanism of pension provision of disabled persons in connection with the loss of breadwinner on the basis of the analysis of the current legislation of Ukraine will create prospects for improving the pension provision of citizens in order to realize the constitutional rights of citizens to social protection, including the right to pension provision in case of loss of breadwinner. The directions of improvement of the pension provision mechanism in case of loss of breadwinner are proposed, such as: raising the size of the pension with the calculation of prices for the consumer basket; promoting public awareness in the functioning of the electronic system of the Pension Fund of Ukraine; technological updating of equipment and equipment to avoid problems in the process of providing services for the population; development and installation of special programs for the protection of personal information of citizens in the electronic system of the Pension Fund of Ukraine and others.


Meningiomas are the most common type of primary brain tumour and when symptomatic, are usually treated by surgical resection. Removing skull-base meningiomas is challenging and subtotal resection remains common, despite utilising the latest surgical

 . In the suprasellar region, surgery is particularly high risk and carries a 10-20% rate of postoperative visual impairment. This morphometric analysis of 40 dry skulls furthers our understanding of anatomical variability of 3 structures in the suprasellar region: the limbus sphenoidale (LS), prechiasmatic sulcus (PS) and optic strut (OS). Understanding suprasellar anatomical variability is vital for neurosurgeons operating within the region to reduce complication rates and in achieving gross total resection.

 Variants of the LS (A, B and C) are defined according to descriptions used from a previous study. Curved and straight lengths of the LS are measured using metal callipers and string. Between the three variants, statistical analysis is used to compare differences in lengths, and the ratio between their curved and straight length. PS angle, length and width are measured according to previous studies' definitions. OS position is determined by measuring its distance from the LS and a drawn midline. Skulls are grouped using PS variables and OS position according to adapted classification systems used in previous studies.

 Variants A, B and C of the LS exhibited incidences of 33.33%, 52.82% and 15.39%, respectively. Limbus ratio was significantly different (p<0.05) between variants. Average sulcal angle was 32 ± 13.3°, whilst sulcal type ranked in prevalence: narrow flat sulci (34.21%)> very narrow steep (28.95%)> very narrow flat (21.05%) > narrow steep (15.79%). 32.50% and 18.42% of struts exhibited notable differences in their distances from the midline and from the LS, respectively.

 The present study improves our understanding of the prevalence of anatomical variants within the suprasellar region and has implications for meningioma surgery. The type C variant is an overhanging ridge, underneath which meningiomas could be hidden from a surgeon's view during transcranial procedures. Only two studies have previously documented the type C variant, whose incidence in the present study (15.39%) is within the boundaries of previous research; patients with this variant might require removal of the landmark during surgery to achieve gross total resection. The PS displayed varying degrees of steepness, and skulls were on average steeper than previously documented populations. A considerable proportion of skulls exhibited notable differences in left and right OS position. Establishing PS morphology and OS position preoperatively might be helpful in reducing the risk of visual impairment in future operations through better understanding the course of the optic nerve.


We consider bootstrap percolation on the binomial random graph $G(n,p)$ with infection threshold $r\in \mathbb{N}$, an infection process which starts from a set of initially infected vertices and in each step every vertex with at least $r$ infected neighbours becomes infected. We improve the results of Janson, \L uczak, Turova, and Valier (2012) by strengthening the probability bounds on the number of infected vertices at the end of the process, using simple arguments based on martingales and giant components.


Based on comparison of two schemes including station layout, power house layout, economical index, construction conditions topographic and geological conditions for the house of Xielibosi power station, an underground power house scheme is recommended.


PP wave and PS wave matching is the basis and crucial portion of joint inversion.This paper presents a PP wave and PS wave time matching method,the method main use PP wave and PS wave velocity ratio to conduct time matching.At development small scale,presents the enlarged scale horizon interpretation method to ensure picking accuracy error within lms,converted-wave layers interpretation primarily refers to PP wave horizons and seismogram.Finally,utilizing the combination of mark layer and wells to achieve fine matching of PP wave and converted-wave data in Lamadian work area,based on this method to conduct PP wave and PS wave joint inversion and gain good effect.


In standard potential-model descriptions of the Be7(p,gamma)B8 reaction the Be7+p spectroscopic factors S appear in the cross section. We argue that the microscopic substructure effects which are represented by S are short-ranged and cannot affect the asymptotic normalization of the wave function. We believe that the standard way of describing reactions in a potential model may be incorrect and the low-energy cross section should not depend on S in the case of external capture reactions, like Be7(p,gamma)B8


This paper will engage in an analysis of horror fans' online discussions of A Serbian Film, dubbed 'the most cut film in 16 years' in the UK. It will show that while many industry reports on downloading or filesharing discuss the practices of participants in terms of piracy, within the context of horror fan community the meaning and function of downloading differs significantly from this economically motivated interpretation. Indeed, within the context of worldwide regulatory practices that have sought to both cut and ban A Serbian Film, these activities may be the only means to gain access to the 'definitive' or 'complete' version of the film. The search for copies of the uncut film online might therefore partly be seen as a search for the 'authentic text' on the one hand, but on the other hand, it can also be suggested that this "shadow economy" (Lobato, 2012) of film is a way for genre fans to perform their subcultural identity. That is, access to and knowledge of 'uncut' and 'screener copies' of such films might be seen as a key way of demonstrating one's social and subcultural capital.


A new mutant leaf character "torn-leaf" in alfalfa (Medicago sativa L.) is described. Segregation in F1, S1, and S2 populations indicates that this character is inherited as a simple recessive. Tetrasomic ratios were observed. The gene symbol tl is proposed for this character.


The Japanese colonists advocating " Leaving Asia and Joining Europe" and " Great Asianism" sugared up their colonization expansion as " a civilizing war of justice" , and alleged that their rule in Taiwan would take Taiwan people from "hell to Eden" . Some are still drumming for the view that Japan brought modernization to Taiwan. The literature of Taiwan during Japanese colonial rule tore that lie apart with realistic descriptions: Legal cruelty, bribery and pervertibility brought insult to Taiwan people; colonial economy led Taiwan peasants to bankruptcy; "Japanization campaigns" hardly changed the inherent Chinese cultural traditions and national identity of the people.


The circulation precooling process of liquid rocket engine is involved with the complicated flow regimes transform and heat transfer that are affected by many factors.The one-dimensional homogeneous balance fluid dynamic model was adopted to analyze the distribution of various parameters of cryogenic propulsion in the precooling pipeline under steady state by discretized method,and investigate the effects of return location,ullage pressure and liquid condensate depression on rocket engine precooling.The results indicate the relative optimal location of return inlet is within 4 m~6 m above the bottom spherical cap,and the engine precooling performance is restained by increase of the ullage pressure and liquid condensate depression.


Hugo Dingler lived from 1881 to 1954. During the academic years 1901–2 and 1903–4 he studied mathematics and physics at the University of Munich. He spent the intervening year (and then the summer of 1906) in Göttingen, where he studied mathematics with David Hilbert and Felix Klein as well as – for the first time – philosophy (with Edmund Husserl). In 1907 Dingler completed his doctorate in Munich with Aurel Voss with a dissertation on general surface deformation. His Habilitation followed in 1912, also at the University of Munich, but only for the prospectless field of "Method, Didactics and History of Mathematical Sciences."


The quarkonia production mechanism in p − p collisions is qualitatively understood by the models based on the Quantum Chromo-dynamics(QCD), in particular, in the non-relativistic QCD (NRQCD) [1]. The quarkonia production in NRQCD is a two step process: First, the creation of the Q ¯ Q pair in a hard scattering at short distances which are process-dependent, is to be calculated pertur-batively as an expansions in the strong cou-pling constant α s . Note that Q ¯ Q states can be in the color-singlet(CS) [2] as well as in a color-octet(CO) [3] states. Second, the Q ¯ Q pair evolves into the quarkonium state with the probabilities that are given by the suppos-edly universal nonperturbative long-distance matrix elements (LDMEs) which have to be extracted from experiments. For CO states, this evolution process also involves the nonperturbative emission of soft gluons to form a CS states. The crucial feature of this formalism is that the complete structure of the Q ¯ Q Fock space, which is spanned by the states n = 2 S +1 L [ i ] J with spin S , orbital angular momentum L , total angular momentum J , and color multiplicity i = 1 , 8. The inclusive cross-section of charmoium include the prompt contribution (the sum of direct production and feeddown contributions from the decay of heavier charmonium states) and the B feeddown. The prompt contribution has been calculated using above mentioned


Differentiating myeloid cells may become resistant to various apoptotic stimuli. In the present study, dimethyl sulfoxide (DMSO) and all‐trans retinoic acid (ATRA) were found to modulate the sensitivity of HL‐60 cells to death receptor‐mediated apoptosis in a time‐dependent manner. During the early stages of differentiation, DMSO treatment increased the response of HL‐60 cells to tumor necrosis factor α; (TNF‐α), but enhanced responsiveness was lost during later differentiation stages. In contrast, ATRA treatment induced resistance to TNF‐α‐induced apoptosis. HL‐60 cells were resistant to Fas‐mediated apoptosis but were sensitized by culturing in serum‐free conditions. Similar to its effect on TNF‐α sensitivity, DMSO pretreatment augmented the response to Fas‐mediated signaling, which coincided with increased expression of Fas on DMSO‐pretreated cells. However, during the later stages of DMSO‐induced differentiation, sensitivity to anti‐Fas antibody‐induced apoptosis declined significantly, although Fas expression was still elevated. The reduced sensitivity to anti‐Fas treatment partially correlated with increased Fas‐associated phosphatase‐1 mRNA expression. Thus, regardless of either Fas up‐regulation or potentiation of TNF‐α‐mediated apoptosis during early DMSO‐induced differentiation, a slow increase in resistance to apoptosis mediated through these death receptors occurs during DMSO‐induced differentiation, which contrasts with the rapid induction of resistance following treatment with ATRA.


The purpose of this study is to test the Influence of Information Technology, Employee awards, Work Discipline, Motivation on Employee Performance at the Regional Tax Service Office of Gunungkidul Regency, Yogyakarta (KPPD). This research is a type of quantitative research conducted in the form of questionnaires on employees and staff at KPPD (Regional Tax Service Office of Gunungkidul Regency, Yogyakarta). This study is to analyze the Influence of Information Technology, Employee awards, Work Discipline, Motivation on Employee Performance in the Regional Tax Service Office of Gunungkidul District. To answer research questions and test the hypotheses proposed, multiple linear regression analysis tools are used. The population in this study was all employees and staff (KPPD) of the district.  Therewere 40 people with characteristics (age, gender, education graduates, marital status, working age) as research subjects. The results showed that 1). Theology Iof information has a positive and significant effect on Employee Performance, 2). Employee Award has no effect on Employee Performance, 3). Work Discipline does not affect Employee Performance, 4). Work Motivation has a positive and significant effect on Employee Performance at KPPD Gunungkidul.
Keywords: Information Technology, Employee Awards, Work Discipline, Work Motivation


The traditional teacher-talk and student-listen English classroom should be reformed in order to meet the needs of college students in modern society.Peer tutoring,as a learning strategy,has been proved effective in English classrooms.This paper discusses the peer tutoring program conducted from September 2005 to January 2006 in the faculty of foreign languages in Ningbo University.The research results indicated that after participating in peer tutoring program,students developed English literacy,became more confident in English-learning and enhanced their communicative ability to some extent.Then it is concluded that peer tutoring program is effective in developing students' English literacy,improving their social performance and advancing their affective development.


The aim is to synthesize Sm (Er)-doped BaSn based nanoscale materials through a simple hydrothermal process and research the photocatalytic performance of the Sm (Er)-doped BaSn based nanoscale materials for the gentian violet degradation.

Sm (Er) doping is an effective strategy for enhancing the photocatalytic activity of the semiconductor photocatalysts for the degradation of the organic pollutants. BaSn based nanorods possess wide band gap energy which limits the photocatalytic application. It is of important significance to research the feasibility of the improved photocatalytic performance of the BaSn based nanorods by doping with Sm (Er).

The aim is to synthesize Sm (Er)-doped BaSn based nanoscale materials through a simple hydrothermal process and research the photocatalytic performance of the Sm (Er)-doped BaSn based nanoscale materials for the gentian violet degradation.

Sm (Er)-doped BaSn based nanoscale materials with poly-crystalline structure were synthesized through a simple hydrothermal process. The Sm (Er)-doped composites were analyzed by X-ray diffraction, electron microscopy, solid diffuse reflectance spectrum, X-ray photoelectron spectroscopy, photoluminescence and electrochemical impedance spectroscopy.

Sm (Er) doping induces the morphological evolution of the BaSn based nanoscale materials from the nanorods to irregular nanoscale particles. Sm (Er) in the doped BaSn based nanoscale materials exists in the form of the cubic Sm2Sn2O7 and orthorhombic ErF3 phases. The band gap value is decreased with increasing the Sm (Er) dopant contents. Sm (Er)-doped BnSnbased nanoscale materials with the Sm (Er) content of 8wt.% has the lowest band gap and shows the strongest light absorption ability. Comparing with the un-doped BaSn based nanoscale materials, the Sm (Er)-doped BnSnbased nanoscale materials exhibit higher photocatalytic activity for the gentian violet degradation. 8wt.% Sm-doped BnSnbased nanoscale materials show the highest photocatalytic activity for the degradation of the gentian violet. 20 mL gentian violet solution (concentration of 10 mg•L-1) can be totally degraded using 20 mg 8wt.% Sm-doped BnSnbased nanoscale materials under the UV light illumination for 150 min.

The enhanced photocatalytic activity of the Sm (Er)-doped BnSn based nanoscale materials can be attributed to the decreased band gap, enhanced light absorption ability and decrease of the recombination of the photo-generated electron-hole pairs.

The Sm (Er)-doped BnSn based nanoscale materials show enhanced photocatalytic performance towards gentian violet.


We have previously shown that HSCT conditioning regimen for severe aplastic anemia (SAA) using fludarabine, cyclophosphamide and alemtuzumab (FCC), is associated with very low rate of GvHD (especially chronic, cGVHD), and excellent overall survival (OS) of 83% and 95% for matched unrelated (MUD) and matched sibling donor (MSD) HSCT, respectively. Sustained full donor myeloid chimerism occurred most frequently with mixed T-cell chimerism, and this persisted despite discontinuation of post graft immunosuppression with ciclosporin (CSA). We proposed that prolonged mixed T-cell chimerism with alemtuzumab conditioning may facilitate tolerance and hence a low risk of GVHD.

We have investigated the basis for the mixed T-cell chimerism in a cohort of 35 patients, median age 32y (range 15-63), transplanted for acquired idiopathic SAA from 2007 - 2014 at King's College Hospital. FCC conditioning comprised fludarabine 30 mg/m2 iv (day -7 to -4), cyclophosphamide 300 mg/m2 iv (day -7 to -4) and alemtuzumab (median dose 70mg, range 45-100). CSA was used as post graft immune suppression for 9 months, followed by dose tapering to zero over the next 3 months depending on PB chimerism. Stem cell source was BM in 7(20%) patients and 28(80%) PBSC, with a median cell dose of 6.8 (1.9-12.4) CD34+ cells x 106/Kg. Donor type was MSD in 9(26%) pts and UD in 26(74%), of whom 20 were matched (MUD) and 6 were 9/10 match ( received FCC with 2 Gy TBI). Median time to neutrophils >0.5x109/l was 12(10-20) days and to platelets >50x109/l was 10(9-61) days. Primary graft failure occurred in only one patient (2%). Acute GvHD was seen in 6(17%) pts (all grade I-II), and chronic GvHD in 5(14%) pts (3 mild, 1 moderate, 1 severe, all with only skin involvement). On univariate analysis with Cox regression model, factors significantly predicting cGVHD were previously diagnosed acute GVHD (p=0.035) and CD3+ chimerism at day+100 ≥90% (p=0.006). Four patients developed autoimmune anemia post HSCT (2 hemolytic anemia, 2 PRCA). Median follow-up was 30 months (4.3-86.8), OS 94% and event free survival 90%. One year TRM was 6%.

Of 32(91%) patients evaluable for chimerism, 8 (23%) were fully donor chimeric for unfractionated BM, PB CD15+ and PB CD3+, while 24 (77%) patients had persistent mixed CD3+ chimerism. Median CD3+ chimerism values were 77% at day+30, 60% at day+60, 41% at day +100,57% at +day180, 70,5% at 1 year, 77% at 2 years and 80% at 3 years. The proportion of evaluable patients no longer taking CSA was 0/23 at 1yr, 9/19 at 1.5yr, 12/16 at 2yr, 12/12 at 2.5yr and 4/4 at 3yr. PB immunophenotyping was performed in 19 patients. During the first year post HSCT, there was profound and prolonged lymphopenia, NK cells recovered first but numbers remained below normal. T cells comprised only 2.6% of lymphocytes at day 30, rising slowly to 41% at day 360 but still significantly below normal (66% in 11 aged-matched healthy individuals), with deficiency greatest for CD4+ T cells. Despite slow recovery of CD4+ T cells, percentage of T-regulatory cells (CD4+ CD25high CD27+ FoxP3+) within this population was normal (range 4.2-7.4% for all time points compared to 5.3% for healthy individuals). Patients aged <50y showed recovery of naive T cells that expressed markers of recent thymic emigrants (CD31+ CD62L+ CD45RA+), indicating renewed thympoiesis and implementation of central tolerance B cell recovery was notably robust, with numbers comparable to healthy individuals for most patients by day 100. Subset analysis showed absence of memory B-cells but significantly increased proportion of immature transitional (T1 and T2) B cells (CD24+ CD38+, CD27-, IgM high IgD high) for 6 months after FCC HSCT. Cells within this subset are known to possess immune suppressive activity.

The mechanism for prolonged mixed T-cell chimerism and associated low incidence of chronic GVHD following FCC conditioning for SAA HSCT may be multifactorial, but we here report novel findings: apart from a markedly low proportion of T cells, we show for the first time in SAA post HSCT the presence of T and B cell subsets with potential regulatory properties and establishment of central tolerance of naive T-cells in younger patients. Our results also confirm the excellent outcomes of UD HSCT using alemtuzumab with reduced intensity conditioning in SAA, and we propose it is now time to re-think the up-front MUD transplant at all ages in eligible patients.

Disclosures No relevant conflicts of interest to declare.


The aim of the treatment of metatarsal(MT) fractures is the anatomic reposition and the restoring of the foot vault. The bony framework is the essential part of the foot vault, which is also decisive for the motion of the ankle. Generally MT fractures are serial fractures. If it comes to a fracture consolidation in malposition, a painful loss of the function of the foot and even the complete lower limb might result [1,2,4,7,8,12]. We carried out an antegrade intramedullary Kirschner wiring of the MT fractures in the shaft area similar to the technique for stabilizing distal fractures of 5th bone metacarpal [13]. This new technique offers advantages compared to others in the literature. It is described by an example of a young man with fractures MT2-4.


2541 Background: CARs usually combine the antigen binding domain of a monoclonal antibody with the ζ signaling domain of the T cell receptor complex. CAR expression in T cells produces potent MHC-unrestricted effector function against tumor cells in vitro but limited T-cell persistence in vivo, likely due to their incomplete activation, as tumors do not express costimulatory molecules. Incorporation of costimulatory endodomains in the CAR (e.g. CD28) may enhance their benefit in vivo.

METHODS
We report a phase I trial of T cells redirected to CD19 given to patients with refractory/relapsed B-cell malignancies. Subjects simultaneously received 2 autologous T-cell products, both expressing CARs with identical CD19-specific exodomains. In one product, the endodomain contained only the ζ sequence (CAR.19ζ) while the second incorporated a costimulatory CD28 domain (CAR.19-28ζ). We generated the T-cell products by activating autologous peripheral blood mononuclear cells with OKT3 followed by transduction with retroviral vectors encoding either CAR.19ζ or CAR.19-28ζ and ex vivo expansion for a median of 14 days (range 6-18) in the presence of IL-2. Six subjects have been treated at 3 cell dose levels (0.2, 1 and 2×108 cells/m2). Persistence of CAR+ T cells was assessed in blood by Q-PCR assays specific for each population.

RESULTS
All infusions were well tolerated. CAR.19-28ζ cells were detected at a low level after infusion, but progressively increased 7- to 63-fold, peaking at 1-2 wk, before declining to background levels over the ensuing 3 mo. By contrast, CAR.19ζ cells were barely detectable after infusion, showed no expansion and disappeared rapidly. Following treatment, 2 patients had stable disease for up to 6 mo and 4 had progressive disease.

CONCLUSIONS
Infusion of both CAR.19ζ and CD19-28ζ T cells is safe at the doses used. Direct comparison of each cell product in individual patients showed that the CD28 endodomain enhances expansion and persistence of the CAR+ T cells. The limited clinical benefits suggest that additional modifications will be required and our approach will allow these changes to be systematically evaluated.


Modelling of the kinetics of a 20-N hydrazine thruster is carried out by considering two different heterogeneous reaction channels for hydrazine decomposition to the intermediate ammonia. The parameters of the reactor model are estimated by making use of temperature profiles at the wall of the decomposition chamber. Simulated ageing of the catalyst revealed an increase of the rate of deactivation with increasing total firing time


Healthcare systems around the world are facing the challenge of information overload in caring for patients in an affordable, safe and high-quality manner in a system with limited healthcare resources and increasing costs. To alleviate this problem, we develop an integrative healthcare analytics system called GEMINI which allows point of care analytics for doctors where real-time usable and relevant information of their patients are required through the questions they asked about the patients they are caring for. GEMINI extracts data of each patient from various data sources and stores them as information in a patient profile graph. The data sources are complex and varied consisting of both structured data (such as, patients' demographic data, laboratory results and medications) and unstructured data (such as, doctors' notes). Hence, the patient profile graph provides a holistic and comprehensive information of patients' healthcare profile, from which GEMINI can infer implicit information useful for administrative and clinical purposes, and extract relevant information for performing predictive analytics. At the core, GEMINI keeps interacting with the healthcare professionals as part of a feedback loop to gather, infer, ascertain and enhance the self-learning knowledge base. We present a case study on using GEMINI to predict the risk of unplanned patient readmissions.


Background. Group method of data handling is a rather underestimated tool for obtaining highly accurate predictive models. The first version of an artificial neural network (which is very popular in the world of machine learning) was obtained in 1965 by the Ukrainian scientist Aleksey Ivakhnenko, who just used the group method of data handling to train the network. It is known that this approach takes place in almost any problematics, and the problem of recognizing coronary heart disease using video data from speckle-tracking echocardiography is not an exception. The solution to this problem is relevant, since it will allow analyzing echocardiograms even if they are not equipped with speckle-tracking technology.
Objective. According to the data of speckle-tracking echocardiography construct classification algorithms by using the group method of data handling for diagnosing violations of the kinematics of left ventricular contractions in patients with coronary heart disease under conditions of rest, and when using echostresstest with dobutamine.
Methods. National Institute of Cardiovascular Surgery provided video data obtained using the speckle-tracking echocardiography method, which examined 56 patients with suspected coronary heart disease. Among them, only 16 patients had no pathology. Echocardiography was recorded in B-mode in three positions: long axis, 4-chamber, and 2-chamber positions. In total, 6245 frames of the video stream were used for the study: 1871 – without cardiac abnormalities, and 4374 – in the presence of pathology during the examination.
Results. Using the group method of data handling, 12 classification models were obtained, taking into account the doses of dobutamine (0, 10, 20, and 40 mcg), the accuracy of which on the examination sample varied from 81.7% to 97.4%. Also, 3 classification models were obtained without taking into account the doses of dobutamine, which on the examination sample showed an accuracy within 75.2-82.2%.
Conclusions. The high-precision classification models were obtained by the group method of data handling. These models can be used to analyze echocardiograms obtained in B-mode on equipment, which is not using speckle-tracking technology.
Keywords: group method of data handling; speckle tracking echocardiography; echostresstest with dobutamine; coronary heart disease.


medical treatment, people with cancer tend to choose different methods to cope with their current situation. In recent years, some studies have drawn their attention on the role of religiosity and spirituality in coping strategies of disease. One significant problem is that many studies in this field have neglected non-religious populations. This presentation will discuss the meaning-making coping strategies among older adults with cancer in Japan and what impact culture has on the coping methods they choose. The presentation will also draw attention on which meaning-making strategies are chosen by cancer patients in a non-religious country like Japan, and to discuss whether meaning-making coping methods can be used in the treatment of cancer.


The problem of online privacy is often reduced to individual decisions to hide or reveal personal information in online social networks (OSNs). However, with the increasing use of OSNs, it becomes more important to understand the role of the social network in disclosing personal information that a user has not revealed voluntarily: How much of our private information do our friends disclose about us, and how much of our privacy is lost simply because of online social interaction? Without strong technical effort, an OSN may be able to exploit the assortativity of human private features, this way constructing shadow profiles with information that users chose not to share. Furthermore, because many users share their phone and email contact lists, this allows an OSN to create full shadow profiles for people who do not even have an account for this OSN. We empirically test the feasibility of constructing shadow profiles of sexual orientation for users and non-users, using data from more than 3 Million accounts of a single OSN. We quantify a lower bound for the predictive power derived from the social network of a user, to demonstrate how the predictability of sexual orientation increases with the size of this network and the tendency to share personal information. This allows us to define a privacy leak factor that links individual privacy loss with the decision of other individuals to disclose information. Our statistical analysis reveals that some individuals are at a higher risk of privacy loss, as prediction accuracy increases for users with a larger and more homogeneous firstand second-order neighborhood of their social network. While we do not provide evidence that shadow profiles exist at all, our results show that disclosing of private information is not restricted to an individual choice, but becomes a collective decision that has implications for policy and privacy regulation. Permission to make digital or hard copies of all or part of thi s work for personal or classroom use is granted without fee provided that copies ar e not made or distributed for profit or commercial advantage and that copies bear this n otice and the full citation on the first page. Copyrights for components of this work wned by others than ACM must be honored. Abstracting with credit is permitted. T o copy otherwise, or republish, to post on servers or to redistribute to lists, requ ires prior specific permission and/or a fee. Request permissions from email@example.com g. COSN'14, October 1–2, 2014, Dublin, Ireland. Copyright 2014 ACM 978-1-4503-3198-2/14/10 ...$15.00. http://dx.doi.org/10.1145/2660460.2660470 .


It is often stated that the ground state is the only bound state of H/ sup -/, and that there exists no excitaticn state. This is based mainly on the aVproximate solution to the 3-body problem. Using a different approach for treating 3-body problems, it is proven that the first excitation state of hydrogen atom can atiract an electron to form an infinite number of bound states of H/sup -/. They are the exci-tation states of H/sup -/. (auth)


The twofold purpose of this study was to ground a model of Lens Meaning in the literature of the Fine Arts and Social Sciences and to use that term as a referent in evaluating three Media Studies curricula. Lens Meaning is a term derived from a variety of sources, particularly Peirce (1955), whose semiotic theory described three systems of signs used as terms on one axis of a matrix or model by which Lens Meaning can be described. These terms are: "index", "icon", and "symbol". DeLauretis' (1984) expanded understanding of another system of signs described by Peirce, interpretants, is the foundation for the three terms on the other axis of the matrix. Those terms, which describe interpretation or response, are: "emotional", "energetic", and "habit changing". These, and other terms identified in the literature, provided a conceptual model that might be applied to the analysis and evaluation of programs of Media Studies, and similar documents. Three Media Studies programs were selected for study: from Western Australia, Ontario, and Scotland. Application of the model permitted conclusions to be drawn on the extent to which current issues of an ideological and sociopolitical nature were addressed by these programs. It was concluded that the model achieved the purposes required of it and that it may be of further utility for educators.


The notion of ethnic field was suggested by L. N. Gumilyov. The field includes two components: energetic and informational. The first one depicts the amount of passionate (creative) energy (engine analogue), the other shows how people having such energy (steering wheel analogue) to act. The authors present a new concept model (pattern) of the ethnic field informational component, based on Pierre Bourdieu and Kurt Lewin understanding of social and psychological fields.The ethnic field concept demonstrates interaction between different ethnic groups and between the ethnos and the landscape as the ethnic field creates its own ethno-cultural layer in the landscape. In the framework of the ethnic field the cultural landscape becomes a text, the meaning of which is clear to the ethnic community having created this field, but it can be obscure to other ethnic communities.This article deals with the method of ethno-cultural information structuring on the materials of northern indigenous peoples' reindeer herding studies. For this purpose we suggest selecting different level contexts similar to the semantic text analysis (one general context may comprise some particular ones). A context is an information construct which defines human behavior stereotypes in the ethnic field. Coming across a problem situation humans think it over in the background of their ethnic field. The ethnic field contextual analysis allows for a better understanding of the causes of tension and conflicts arising in ethno-contact areas. Refs 12.


Objective:To explore the postoperative analgesic effects,adverse reactions of flurbiprofen axetil injection and the efficacy of it for the movement pain and functional recovery on orthopedic surgery patients.Methods:60 cases of elective surgery were randomly divided into two groups:the flurbiprofen axetil(test group),opioids + non-steroidal anti-inflammatory drugs(control group).Record the VAS score,side effects(nausea,vomiting,drowsiness,gastrointestinal bleeding,respiratory depression,etc.),night pain under resting conditions at 1,6,12,24h after the surgery,and the movement pain after the first 48h-72h,respectively.Results:The experimental group's VAS score was significantly lower than control group(P0.05),the experimental group and fewer adverse reactions(P0.05),the experimental group's analgesic effect of movement during the first 48h-72h analgesic effect of movement is significantly better than the control group(P0.05),and the night-time resting pain of the experimental group tends to be lighter than the control group(P0.05).Conclusions:The analgesic effect of flurbiprofen axetil is good,especially for movement pain,and is significantly superior to common opioid,and less adverse reactions,which is more conducive to postoperative functional recovery.


The paper is introduced by a short survey of heat-transfer processes through a double-glazed window system. Network calculations show the advantage of a double-glazed window including at least one heat-reflecting filter and an IR-trans-parent foil. In the optimum system with one foil, the UL value is slightly below 1 W/m2K. Several insulating glazing systems with air and with krypton filling are compared, and all UL values are calculated. the application of an IR-transparent foil to a solar collector is discussed, and the measured top losses are given.


Objective
To evaluate curative effect of Ding Kudan (DKD) on kidney-deficency syndrome of delayed menorrhea due to decreasing ovarian reservation (DOR).

Methods
Sixty-two patients were divided into treatment group and control group randomly, 31 patiens for each group, the treatment group applied DKD and the latter applied climen for three months.The clinical syndrome scores, follicle-stimulating hormone (FSH), FSH/luteinizing hormone (LH), anti-Mullerian hormone (AMH), mean ovary volume (MOV) and antral follicle count (AFC) scores of the patients before and after treatment were compared.

Result
The total effective rates of treatment group and control group were 93.55% and 83.87%, respectively. After treatment, there were significant differences between the two groups in the distribution of Traditional Chinese Medicine syndromes (P=0.006 8). Treatment group and control group had the same curative effect for improvement of hormone level and MOV, but DKD in the improvement of AMH and AFC was better than Climen.

Conclusion
DKD for kidney patients with late menstrual ovarian reserve function has a good treatment effect. It can effectively improve patient sex hormone levels, increase the average ovarian volume and the sinus follicle count, promote the menstrual flow, and improve the ovarian reserve function.

Key words:
Decreasing ovarian reservation (DOR); Nephrasthenia syndrome; Ding Kundan; Delayed menorrhea


The utopia of finding a perfect language has haunted the imagination of the greater thinkers of western culture. In this work Umberto Eco exposes the different theories of a perfect language, theories which could produce the linguistic unity of Europe, and the consequences that these have had not only to thought but to the western life in general, because many of the social, political or economical questions are mingled along the history, with the problem of a perfect original language: or language imitates things, or is it a mere convention, or it reflects a sort of spiritual order. The passing from a thought of Babel as a god?s punishment to a concept of a symbol of universal unity in diversity has not been a sole theoretical exercise, but also has made easy to us the understanding of a multilingual European reality and the impulse still existent to the search of a universal human communication code.


Photocatalytic splitting of water by nanostructure on suitable semiconductor surface receives wide attention due to their potential application for both clean energy production and environmental difficulties. Clean energy production and overcoming environmental issues at a worldwide level got the significant attraction. So it is crucial to construct a system that can produce clean energy in order to resolve such issues. Since hydrogen is an ultimate source of green energy. At present, hydrogen is mostly produced by petroleum and natural gas at high temperature, which needs massive energy. Therefore, the expansion of an unconventional hydrogen production technique is undoubtedly imperative to mitigate environmental and energy issues.


Authors study a distribution system which consists of a warehouse and n clients(such as retailers, wholesaler,and so on, but not final consumer of product). The problem about distributing inventory in center warehouse to each client economically and reasonably,and then optimizing the whole system is the inventory/transportation integrated optimization (ITIO) problem. In this course of distribution,the product quantity of each client and optimal distribution route must be simultaneously considered,so the ITIO problem is more complicated than single inventory problem or single transportation problem. Therefore,the study on how to solute the ITIO problem on the basis of FPP theory is more practically valuable. Authors explain the characteristics of the problem studied,discuss a procedure of handling the random demand as the determinate demand, establish a model,and finally design the heuristic algorithm based on the method for solving the constrained concentrator location problem.


Diversity in geographical circumstances proved basis that formed regional character of national culture,Whilst recognition and admission of similarity of human intelligence and generality of human basic values turned out human civilization's common principles.By exploration on consensus as to different nationality culture."Pair-Off in Xiaocheng Village——International Civilian Art Festival" undoubtedly with realistic significance especially today when human entity and global completeness experienced gigantic destruction and trapped into unexpected crisis.


The problem considered is that of optimizing the settings of control valves in order to minimize leakage losses in water supply networks over a number of periods with different demands representing the diurnal variation. Two models, one for the case of constant-outlet-pressure valves and one for the case of flow-modulated valves, are formulated. Case studies and computational experience are discussed.


ABSTRACT: This article aims at discussing the contributions of the Bakhtinian Circle theories to the foreign language teaching in the beginning years of formal education in Brazil, which is not, to the present moment, officially part of the National Curriculum. Due to the importance of English in a globalized world, its controversial socio-educational impacts and the irregular increase in the implementation of such discipline in the first grades of Ensino Fundamental I at public schools, the relevance of this work lies on the grounds it may offer to the elaboration of transformative theoretical and practical guidelines for the given teaching-learning process.


FIELD: pigments, coatings. SUBSTANCE: proposed layered pigment exibits high lustre, covering capacity or high transparency. Pigment consists of cleared, inorganic, layered matrix that can contain additional component. The latter is a soluble or insoluble dye. To required lustre obtain matrix is covered (at least of one site) with a single or few thin, cleared or semi-cleared reflecting layers of metals or their oxides. EFFECT: high quality of pigment.


In the present study, a hydraulic shock absorber is proposed. Since the damper is mainly used in suspension energy recovery system, the damping characteristics of the damper under no-load state are studied in this paper. Structural design is conducted so that the unidirectional flow of the oil drives the hydraulic motor to generate electricity. Meanwhile, an asymmetrical extension/compression damping force is obtained. A mathematical model of the shock absorber is established, and the main characteristics of the inherent damping force are obtained. Based on the established model, effects of the accumulator volume, accumulator preinflation pressure, hydraulic motor displacement, check valve inner diameter, and spring stiffness, hydraulic line length and inner diameter on the indicator characteristics are analyzed. Moreover, a series of experiments are conducted on the designed damper to evaluate the characteristics of the inherent damping force and analyze the effect of the accumulator volume and preinflation pressure on the damping characteristics.


Calcium-related proteins include transient receptor potential vanilloid (TRPV) 5 and 6, plasma membrane calcium-ATPase 1b (PMCA1b), and calbindin-D9k and -D28k. The TRPV6 is a major calcium channel located in the apical and basolateral membranes of cell and distributed widely in many other organs, especially in the exocrine tissues such as intestine and uterus. TRPV6s are generally regulated by vitamin D, a dietary calcium ion and hormone. In particular, uterine TRPV6 appears to be affected by sex steroid hormones, which are altered according to estrous cycle and pregnancy. In order to discover the effect of sex steroid hormones on the regulation of TRPV6, we examined the expression of TRPV6 mRNA by using RT-PCR and real-time PCR, and protein expression of TRPV6 by immunohistochemistry (IHC) in the uterus, duodenum, and kidney. To evaluate the effect(s) of sex steroid hormones on its uterine, duodenal, and renal regulation, 17β-estradiol [E2; 40 μg kg–1 of body weight (bw)] and/or progesterone (P4; 4 mg kg–1 of bw) or vehicle (n = 6/each group) were subcutaneously injected into Sprague-Dawley immature female rats (14 days old, n = 24 in total) for 3 days. As a result, the treatments of immature rats with E2 or P4 increased TRPV6 mRNA for calcium function or regulation in the uterus of immature rats. To confirm the specificity of E2 or P4 through their receptors, we treated the immature rats (extra n = 24 in total) with an estrogen receptor-antagonist, ICI 182,780 (ICI; 30 μg kg–1 of bw), and/or progesterone receptor antagonist, RU 486 (10 mg kg–1 of bw), at 3 days prior to E2 or P4 injection. Consequently, an increase in TRPV6 mRNA was observed in the following 2 treatments; ICI plus E2/P4 and E2/P4 alone. In IHC, we further observed that the expression of duodenal TRPV6 was increased by E2 or P4 and E2 or P4 plus ICI, while no difference was observed in renal TRPV6 by the treatments of sex steroid hormones. In conclusion, these results indicate that the expressions of uterine and duodenal TRPV6 may be induced by E2 and P4, but its renal expression may not be controlled by these steroids.


Whether truthfulness is to be taken as the basic principle in rhetorical studies, or even, a principle of moral and value judgment results from two different rhetorical ideologies. Scholars who believe in the former fall into school of truthfulness while the opposite into school of techniques. While most people generally think that western rhetorical studies concentrate more attention on rhetorical methods and techniques, they neglect the fact that truthfulness has been always emphasized by quite a few western scholars in the history of rhetorical studies. The writer of this paper holds the view that the difference of the two ideologies lie in their different understanding of the nature, purpose and use of the rhetoric. The difference, therefore, causes a discrepency in acceptability of appropriateness. In fact, there exist amazing similarities in the western and eastern schools of truthfulness. The reason for it, as the writer observes, is that they both regard rhetoric as a lofty ideal, for it plays an important role in cognition and communication. Truthfulness principle is not an additional moral standard placed on rhetoric; rather, it is the indispensable factor that helps rhetorical uses to function.


During the process to assemble the product which is complex and requires the high precision of the matching, to get the optimal assembly combination, to consider the effect of the closed loop on the fitted position, put forward three methods to improve the selective assembly, including parallel processing optimum, principal processing optimum and down to top matching method.


Abstract : Interior ballistic data from 20 tests with a 30-mm regenerative liquid propellant gun (RLPG) are examined. The tests are divided into four groups, with five tests in each group. The particular RLPG, referred to as Concept VI, is based on an annular-sheet-type of injector. The propellants used for the tests were liquid gun propellant (LGP) 1845 and LGP 1846. The mean muzzle velocity and the standard deviation for the first three groups was 855 ms (1.0%), 903 ms (1.9%), and 867 ms (2.1%). For groups 2 to 4, the igniter charge was increased from 3.0 g to 3.5 g. The significant increase in velocity for the second group of tests could riot be explained by the small increase in the igniter charge. The increase in velocity, as well as the large standard deviations, is presently under study. Interestingly, the fourth test group, in which the initial conditions were more closely controlled, yielded a mean muzzle velocity of 873 ms with a standard deviation of 0.83%. Because of the large variations in the first three group of tests, especially when compared with other RLPG firing test data, a study of some of the parameters was undertaken which might influence the muzzle velocity. regenerative liquid propellant gun, muzzle velocity, repeatability, liquid propellant.


In this study, the influence of the recrystallization of an alumina trihydrate (ATH) filler on the leakage current development in a salt-fog ageing test for polymeric materials was investigated. The possibility of the recrystallization of ATH was confirmed by differential thermal analysis (DTA). The intensity of ATH in X-ray diffraction (XRD) profiles showed a fluctuant change in salt-fog and dry periods, and the measured leakage currents during different ageing cycles also showed a fluctuant change with the dehydration and recrystallization of the ATH filler. Thus, the leakage current can be well suppressed by the recrystallization of the ATH filler, and the lifetime of ATH-filled polymeric materials can be prolonged when they are exposed to electrical stress under wet conditions.


The present study was carried out in Hisar district o f Haryana state with an objective to assess the depression among senior citizen. A total o f 100 elderly equally representing both living arrangements i.e. living alone and living with family, were selected randomly for the present study. Depression o f senior citizen was taken as dependent variable, whereas, level o f physical dependency, personal and socio-economic variables were considered as independent variables. Results related to the dependency status indicated that the marginal percentage o f elderly were totally dependent in both living arrangements. Further maximum percentage o f elderly living in family were dependent for heavy work as compare to the respondent living without family where, maximum percentage of respondent were independent. Data highlighted that higher percentage o f respondent living with family had mild level o f health, whereas, respondent living without family had different trend showing fifty percent had moderate level o f health status. Female respondents were having higher depression as compared to male counterpart.. Elderly who were living alone were having higher level o f depression as compared to elderly who were living with their family.


3D -DD simulations are performed with cubic grains ranging from 1 to 10 μm to investigate the physical mechanisms at the origin of the Hall- Petch law. In particular, the long-range stress (back stress) induced by the density of polarized dislocations ( GNDs ) accumulated at GBs is quantified separately from the short-range stress associated with the forest dislocation ( SSDs ) density. We show that the back stress and the associated strain hardening is independent of grain size at low strain. Hence, the grain size effect reproduced by 3D-DD simulations is controlled by an increase of the CRSS when decreasing grain size. Such evolution of the CRSS amplitude is controlled by two competing strengthening mechanisms justifying the generic <i>1/√d</i> dependent form of the Hall- Petch law observed in simulations and experiments.


The literature appears to contain no reference to the nitration of either benzhydrol or diphenylbromomethane. However, the somewhat unexpected results obtained (1) on nitrating diphenylacetic acid, coupled with a desire to explore alternate routes to the preparation of 4,4'-dinitrodiphenylacetic acid, led us to make the present study. Benzhydrol waa nitrated at 30" with an excess of white fuming nitric acid. The crude product melted over a wide range, but on fractional crystallization from e tbno l or glacial acetic acid there finally was obtained a small yield of 4,4'-dinitrobenzhydryl nitrate2 as white needles, m.p. 160.5-162'. The structure of this product was proved by elemental analysis and by oxidation to the known 4,4'-dinitrobenzophenone. Also, an infrared spectrum of the nitration product showed no OH band. It was hoped that hydrolysis of this nitrate ester under mildly reducing conditions would permit the isolation of 4,4'-dinitrobenzhydr01.' However, hydrolysis in aqueous ethanol containing sodium suI.6.de produced 4,4'-dinitrobenzophenone in 55% yield as the only product isolated. In a search for other products formed in the nitration of benzhydrol the crude nitrated product from a separate nitratian waa subjected to a very tedious fractional crystallization from glacial acetic acid, ethanol, dioxane, and benzene in the order named. In this way a small amount of 3,4'-dinitrobenzophenone waa obtained. The nature of this unexpected product waa suggested first by its infrared spectrum and was confirmed by elemental analysis and mixture m.p. with authentic 3,4'-dinitrobenzophenone. No 4,4'-dinitrobenzhydryl nitrate was isolated from this nitration. The small amount of the two products obtained from nitrating benzhydrol makes it impossible to state whether either is the main product, particularly since the two products were obtained from separate nitrations. Similarly it seems unwise to postulate a mechanism for the reaction. Nevertheless, it is worth noting that nitration of diphenylacetic acid unexpectedly produced the 3 , 4'-dinitro derivative as the only product isolated (1). Diphenylbromomethane, nitrated as in the case of benzhydrol, produced a gummy crude product melting over a wide range. Several crystallizations (less tedious than in the case of nitrated benzhydrol) from acetic acid finally produced


Muhammad Ali Jinnah called for the division of India on 22ndMarch 1940 in his presidential address to the annual session of the All-India Muslim League held at Lahore. Immediately, the League were beset with not only opposition from all flanks but also the allegation that Jinnah's idea of Pakistan was ill-defined and merely a counter for bargaining. Even after Pakistan's independence in 1947, this theory was furthered to the extent of being elevated to orthodoxy. This paper examines Jinnah's private correspondence dealing with the nature of Pakistan, in particular Jinnah's 1941 letter to the League leader Nawab Ismail that refers to findings of the Reforms Commissioner H.V. Hodson regarding Pakistan, and is often cited as evidence of Jinnah's 'real aims'. In parallel, Jinnah and prominent League leaders' dealings with the British are analyzed in order to reconcile their disparate stances.


The impulse responses and other acoustical parameters of Huangpu Teenager Palace were measured. Meanwhile, the acoustical simulation based on software ODEON was carried out as well. The parameters based on computer simulation are compared with the measured ones. This case study shows that the auralization technique based on computer simulation can be used for predicting the acoustical quality of a hall at its design stage.


A Groupwise Non-Rigid Registration Approach for Accurate Quantification of DCE-MRI in Characterizing Ovarian Cancers Elahe Kia, Anahita Fathi Kazerooni, Alireza Ahmadian, and Hamidreza Saligheh Rad Medical Physics and Biomedical Engineering Department, School of Medicine,Tehran University of Medical Sciences, Tehran, Tehran, Iran, Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging,Tehran University of Medical Sciences, Tehran, Tehran, Iran


The invention provides a thermoregulation dehumidification system which comprises refrigerating cycle and an indoor fan, wherein the refrigerating cycle is formed through connecting a compressor, an indoor condenser and an outdoor condenser positioned on the downstream of the compressor; the indoor condenser is arranged on the upstream of the compressor; the indoor condenser and the outdoor condenser form a parallel branch; the thermoregulation dehumidification system comprises a blowing-in temperature sensor used for measuring air temperature from the indoor condenser and a superheating temperature detection mechanism used for measuring refrigerant vapour sucked by the compressor; in the parallel branch, the downstream of the outdoor condenser is provided with an outdoor adjustable throttling device, and the downstream of the indoor condenser is provided with an indoor adjustable throttling device; and the indoor adjustable throttling device causes an opening of the indoor adjustable throttling device to be adjusted based on the measured air temperature, and the outdoor throttling device causes an opening of the outdoor adjustable throttling device to be adjusted based on the measured superheating temperature. The invention also provides a method used for thermoregulation and dehumidification in indoor air.


Abstract : Inertia and temperature effects in entrance flow between parallel flat plates are investigated by using both boundary layer theory and an approximate analysis. The approximate theory is implemented by a gas table similar to those for conventional Fanno-line computations. (Author)


ALTHOUGH the Dust Bowl of the 1930s had a significant influence on the adoption of national conservation programs, wind erosion generally has been perceived as a regional problem occurring only during periods of drought in the Great Plains. U.S. Department of Agriculture (USDA) resources have been directed primarily toward water erosion prediction and control. Development and use of the wind erosion equation (WEQ) has taken place in this setting.

More recently, awareness has developed that wind erosion is also a problem of national scope. Wind erosion is now a recognized problem, in several areas outside the Great Plains, including the sandy and organic soils of the Great Lakes region, the sands of the Gulf and Atlantic Coastal Plain, the Columbia River plateau, and parts of the Southwest. In higher rainfall areas, the most serious problems occur where low-residue crops are grown on erodible soils that dry rapidly at the surface.

Early wind erosion research

Early U.S. and Canadian wind erosion research sought to understand erosion processes and develop workable methods of control (3, 4). Stubble mulching investigations, for example, were being conducted at 16 research locations in the 17 western states as early as 1957 (9). Although …


The paper of Aslan et al. (1) in this issue, demonstrating a link between certain β-adrenoceptor polymorphisms and the development of transient tachypnoea of the newborn, is the latest to address the question of the physiological mechanisms controlling liquid movement across the respiratory epithelium at birth – a question that has long exercised respiratory physiologists (see reference 2 for a recent review of the developmental regulation of lung fluid transport). The abrupt removal of the liquid present within the lung at birth is perhaps the most dramatic demonstration of the importance of lung transport mechanisms that operate throughout life, and it is consequently not surprising that paediatricians (including paediatric pathologists) and obstetricians have been at the forefront of attempts to understand the key physiological mechanisms underlying these processes. Knowledge of the fluid absorptive capacity of the lung is more than 150 years old (3) but until the late 1970s it was believed that the removal of lung liquid at birth was a passive process due to the compression of the chest during its passage down the birth canal. However, there are several lines of evidence which argue against this simple explanation (see 2), not the least of which is the observation that occlusion of the trachea in experimental animals does not impede lung liquid absorption. It had already been established that lung liquid is secreted by a process involving 'active' chloride transport (see 2) when Enhorning and co-workers (4) and Walters and Olver (5) demonstrated the key role of β-adrenoceptor stimulation in the rapid switch in the direction of net liquid movement across the lung epithelium at birth. Enhorning et al. (4) noted the dehydrating effect of the synthetic β-adrenoceptor


Purpose Main aim of this study is to examine the relationship among young consumers etnocentrisim, brand love and brand loyalty. The effect of coffee shop selection criteria and ethnocentric tendencies and brand love on brand loyalty is also studied among university students in this paper. Results of study show there is strong relationship among ethnocentric tendencies, brand love and brand loyalty. The study aims to Design/methodology/approach Data was collected among 285 graduate and post graduate students in Aydın, Turkey. It was analyzed by using confirmatory structural equation modeling (SEM). Findings The study's findings indicate a significant relationship between ethnocentric tendencies, brand love, and brand loyalty. Additionally, brand love partially mediates the link between customer ethnocentrism and brand loyalty. Research limitations/implications The sample was relatively limited and it involved participants from only one of Aydın Adnan Menderes University students. Keywords:consumer ethnocentrism, brand love, brand loyalty, structural equation modeling


FMR measurements have been carried out on several members of the Ln 1−x Sr x CoO 3 (Ln=Rare earth) system. The results show that g eff in these systems is around 1.25 independent of x as well as the rare earth ion. It is suggested that this unusual value of g eff is due to the localized intermediate-spin Co 3+ ions (t 5 2g e 1 g ) located at the top of the π ∗ band.


Objective:To evaluate Hb Bart's levels in neonatal cord blood as an early clinical diagnostic method for alpha-thalassemia carrier detdction.Methods:A total of 1006 neonatal cord blood samples collected form shaoguan Maternal and Child Health Care Hospital were screened for α-thalassemia carriers with both Hb Bart's level and molecular screening method simultaneously. The sensitivity and specificity of Hb Bart's levels method were analyzed.Results:Hb Bart's was detected in 64 out of 1006 cord blood samples, the positive rate for Hb Bart's being 6.36%.Concentrations of Hb Bart's varied form 0.70% to 98.90%. Abnormal hemoglobin variants were also found in 6 samples(0.59%). In these positive samples for Hb Bart's, α-thalassemia mutations were detected in 64 samples, but α-thalassemia genes were detected in 38 out of 906 in the negative samples for Hb Bart's. Therefore, the incidence of α-thalassemia mutation was calculated as 10.44%. The overall diagnostic concordant rate of Hb Bart's screening method for α-thalassemia was 62.1%. When α-thalassemia with - SEA αα,-ααα,αααα T,- SEA -α and αααα genotypes, the dianostic concordant rate of the method was 100%, 19.1%, 100%, 100% and 99.8%,respectively. The false positive rate for α-thalassemia alleles was 3.1% and false negative rate for α-thalassemia with -ααα mutation was up to 36.2%.Conclusion: Hb Bart's level in the cord blood used as early clinical screening for various α-thalassemia is simpler and faster, more economic and easier to perform compared with the molecular screening method, but for silent α-thalassemia carriers. this method is unreliable and imprecise.


We have developed semiempirical total reaction cross section formulas for proton-nucleus (with ${\mathit{Z}}_{\mathit{t}}$\ensuremath{\le}26) and nucleus-nucleus (with ${\mathit{Z}}_{\mathit{p}}$ and ${\mathit{Z}}_{\mathit{t}}$\ensuremath{\le}26) reactions. These formulas apply for incident energies above \ensuremath{\approxeq}15 MeV and \ensuremath{\approxeq}100 MeV/nucleon, respectively. We have also constructed a procedure for calculating the projectile-fragment production cross sections, by scaling semiempirical proton-nucleus partial cross section systematics. The scaling is done by a scaling parameter, which is based on a Bradt-Peters-type law and also takes advantage of the weak-factorization property of projectile fragments. All products from the Z of the projectile down to Z=2 can be calculated. The agreement between the calculated partial cross sections and the experimental data is better than all earlier published results.


Satellite communications using millimetre waves, in Ka band and above, experience significant fading by rain. Strong attenuation is experienced between the ground station and a level known as the rain height, in ITU-R recommendations assumed to be 360 m above the zero-degree isotherm (ZDI). This study examines National Oceanic and Atmospheric Administration National Centres for Environmental Prediction (NCEP)/National Centre for Atmospheric Research (NCAR) Reanalysis 1 data to identify changes in the ZDI height over the last 30 years. Near the equator and the poles the ZDI height has been approximately stable over this period. However, in mid-latitudes, different regions show trends of increasing or decreasing ZDI height. Over the economically important regions of North America, China and Western Europe, the ZDI height has shown an increasing trend with peak rates in the range of 8–10 m per year. Given a 20-year life-time of a satellite system, this could lead to a 10–20% increase in fade intensity from a similar rain event. The effect will be compounded by increasing trends in the incidence of heavy rain recently identified in UK data. These trends will need to be considered when designing new systems.


Present invention discloses a multi - cell quickly switching method. It contains A, messages source BSC ( base station control base station control unit ) transmitting switching applying messages having switching target cell list to MSC ( mobile switching center switching center ), B, MSC simultaneity transmitting switching request to all cell BSC in list, each BSC establishing wireless channel resource switching request, C, if wireless channel resource establishing successfully, then transmitting switching confirmation request messages to MSC, MSC selecting first received a switching confirmation request message corresponded cell as switching target cell, switching command message to source BSC, proceeding switching operation. Said invention can raises cell switching speed and success rate.


The article presents psychological analysis of the concept of faith and considers the etymology of this word in other langu ages, which allowed to identify its core meanings: loyalty, service, sincerity, con viction, truth, correctness. Such functions of faith as emotional-therapeutic and com municative were substantiated. Religious faith was described as confidence in the real existence of God (transcendental), striving to self-transce ndence, going beyond one's capabilities and knowledge. The psychological features of religious faith were identified.


[Objective]To understand the prevalence of chronic non-infectious diseases in urban and rural residents in Dalian,to provide basis for prevention and control of chronic diseases.[Methods]Investigation was conducted among the permanent residents aged over 20,selected with stratified cluster sampling method from 11 districts(counties) from May to August,2006 in Dalian.[Results]Of the 6 304 residents investigated,the prevalence rate of hypertension was 26.74%,impaired glucose tolerance(IGT) was 10.34%.The incidence rate of diabetes mellitus,coronary heart disease and cerebral apoplexy was 8.17%,6.23% and 1.36% respectively.The prevalence rate of diabetes mellitus and coronary heart disease was 7.15%,4.99% and 9.14%,7.41% in male and female respectively(P0.01).The prevalence rate of cerebral apoplexy was 1.73% and 1.02% in male and female(P0.05).The prevalence rate of diabetes mellitus and IGT was 9.15%,8.80% in urban residents and 7.61%,11.22%(P0.01 or P0.05) in rural residents.There was a difference of the incidence of the 5 chronic diseases in the residents with different age and different educational level(P0.01 or P0.05).[Conclusion]The prevalence rate and risk factors of chronic diseases in urban and rural residents was higher in Dalian.


In the distribution generation system the use of power electronics technology together with renewable energy sources plays an important role for satisfying the increasing demand of electric power all over the world. Among the various distribution generation technologies, fuel cell based distribution system appears to be a promising technology. In this paper, a Solid Oxide Fuel Cell for distribution generation application is introduced. The mathematical modeling of the fuel cell is studied and simulation study of the interfacing power electronics converters is done in this paper. The physical model of fuel cell stack and power conditioning units are described in this paper. The control design methodology for each component of the proposed system is also described. A MATLAB/Simulink simulation model is developed for the SOFC DG system by combining the individual component models and the controllers designed for the power conditioning units. Simulation results are given to show the overall system performance including the real and reactive power compensation capability of the distribution system.


The invention provides a method for utilizing ultrasonic wave assistant supercritical carbon dioxide for preparing mesoporous tin antimony oxide powder. According to the method, a certain amount of SnC14.5H2O, a certain amount of SbC13, ammonia water and surfactant are weighed accurately according to the formula, added into a certain amount of distilled water, stirred to be dissolved fully, and prepared into a solution; the solution is placed into a supercritical reaction kettle, a carbon dioxide steel cylinder is opened, and carbon dioxide gas is cooled into liquid through a refrigerator, is pressurized through a high-pressure pump and then enters the reaction kettle; an ultrasonic device is started, certain pressure and temperature are controlled, and the pressure is kept for a certain period of time; a pressure relief opening is opened to enable the pressure in the supercritical reaction kettle to fall to normal pressure to obtain precursor powder; the collected powder is calcinated at the temperature of 500 DEG C-800 DEG C, so that the mesoporous tin antimony oxide powder is obtained. Toxic organic solvent is not used in the preparation process, and therefore pollution to environment is avoided; the prepared tin antimony oxide powder has large specific surface area and has excellent heat insulating, conducting and static resisting performance, the process is simple, and cost is low.


We present the results of microwear studies of a sample of scrapers, from the excavations at the site Cueva de las Manos -layers 4c, 5 and 6-, dated between 1610 bp to 9300 years bp. We are interested in defi ning on what type of raw material these scrapers worked, since this subject wasn't previously analyzed. On the other hand we are interested in extending the study of the morphologic variability of scrapers, in relation to their functional variability. Especially considering that this site presents a remarkable number of instruments classifi ed as scrapers and rabots. These new results will allow going deeper in the discussion started by Cattaneo in previous works. A differentiation was established in them between certain subgroups of scrapers working only on one type of material and other groups which combined several types- at least two of them. Also, we reintroduce the observations made with the Laser Confocal Scanning Microscope BioRad MRC600, that were also analyzed with the "PHILOS" software for image recognition.


Farmer perception of their environment is a factor of climate change. Adaptation to climate change requires farmers to realize that the climate has changed and they must identify useful adaptations and implement them. This study analyzed the per-ception of climate change among rural farmers in central agri-cultural zone of Delta State, Nigeria. Climate change studies often assume certain adaptations and minimal examination of how, when, why, and conditions under which adaptations usually take place in any economic and social systems. The study was conducted by survey method on 131 respondents using struc-tured interview schedule and questionnaire. Data were analyzed with descriptive statistics and linear regression model to test that education, gender, and farming experience influenced farmers' perception of climate change. The results showed that the farmers were aware of climate change. The identified causes of climate change were ranging from intensified agriculture, population explosion, increased use of fossil fuel, loss of in-digenous know practice to gas flaring. The effects of climate change on crops and livestocks were also identified by the rural farmers. Many of the farmers adapted to climate change by planting trees, carrying out soil conservation practice, changing planting dates, using different crop varieties, installing fans in livestock pens, and applying irrigation. Almost half of them did not adapt to climate change. The linear regression analysis revealed that education, gender, and farming experience influ-enced farmers' perception of climate change. The major barriers to adaptation to climate change included lack of information, lack of money, and inadequate land.


Background: Shift work is common in today's society. About 75% of shift workers have problems regarding sleep and recovery. Research has investigated shift worker's physical and psychological probl ...


The management of body weight and lifestyle habits is important for the maintenance of health in working people. Accurate self-perception of weight status is thought to be an important aspect of maintaining ideal body weight and successful obesity or leanness-related disease prevention and management. Overweight and underweight are dominant risk factors for noninfectious chronic diseases, also called noncommunicable diseases (NCDs). NCDs have recently become important targets for health interventions worldwide. According to the Global Status Report on Noncommunicable Diseases 2014, NCDs account for 68% of deaths worldwide. Many studies have found that most NCDs are associated with unhealthy lifestyle habits, such as unhealthy diet, physical inactivity, smoking, and excessive alcohol consumption . In Japan, the incidence of NCDs is increasing because more people are becoming overweight or underweight, resulting in a major public health problem. Middle-aged and elderly populations are often overweight and young women are likely to be underweight. A 2013 study found that >30% of men aged 40–69 years old were overweight, and 21.5% of women aged 20–29 years old were underweight. During the second term of the National Health Promotion Movement in the 21 Century (Health Japan 21 [second term]), goals will be established for maintaining ideal body weight, eating a healthy diet, exercising routinely, and increasing physical activity. Body weight is an easy measurement for people to monitor themselves. The ability to recognize and maintain an ideal body weight is important for preventing many NCDs. Previous studies on ideal body weight and body image have focused on children or adolescent females , but few of these studies have addressed male workers. Few studies have focused on BMI and on weight self-perception in the working population , and our review of the literature found none that examined the relationship between weight perception and lifestyle habits. We investigated weight self-perceptions and health-related behaviors of male Japanese bus drivers and described the impact of weight perception and lifestyle on their physical condition and health problems.


FIG. 1.n Cow demonstrating mild ulceration of the muzzle due to bluetongue virus infection.n
n
FIG. 2.n Cow demonstrating more progressed ulceration of the muzzle due to bluetongue virus infection.
n
Bluetongue viruses are infectious, noncontagious viruses in the family Reoviridae and genus Orbivirus that are transmitted to domestic and wild ruminants (sheep, cows, goats, deer) by biting midges (no-see-ums) in the genus Culicoides (Fig. 3) (6).n nThe viruses are nonenveloped and the icosohedral 85-nm-diameter capsid contains the 10 segments of the linear double-stranded RNA genome of approximately 25 kilobases (4, 5). The disease is found worldwide in sheep, goats, and cattle (ruminant species).n Due to the seasonal increase in the vector, disease is most prevalent mid summer to early fall.
n
Bluetongue virusninfection in cattle is very similar to infections in sheep, although morbidity and clinical signs of disease in adult animals are much lower, usually about 5% versus 50 to 80% in sheep.n Factors such as severe weather, infection with parasites, poor diet, and stress are known to exacerbate mortality in sheep.n Disease signs include fever (usually 104 to 106oC), depression, and lassitude beginning 6 to 8 days postinfection.n The disease progresses to redness and swelling of the mucous membranes of the mouth (Fig. 1nand 2), eventually leading to ulceration of the mouth and nose (Fig. 2), sometimes giving a burnt appearance. Signs as severe as those seen in Fig. 2 are rare. Mild infections often go unnoticed.n Although the virus is infectious in cattle and most animals in infected herds show serologic indication of infection, few show disease signs. Full recovery usually occurs within 10 to 14 days.n Milk production decreases as a result of infection can occurn (1


A hierarchically controlled IP+Optical multilayer Transport SDN architecture is proposed, which highlights flexible resource provisioning and dynamic cross-layer restorations. The proposals are also demonstrated via an implemented testbed prototype.


This paper discusses an externally-funded project into Scottish coaches' awareness of the sports concussion prevention initiative, If in Doubt, Sit Them Out. It explores the short-term risks of concussion to youth participants in particular before analysing the data from interviews with ten coaches of girls' football. The coaches' apparent lack of awareness of the policy are highlighted and the possibility that the different resources in girls' and boys' football, and between girls' performance and girls' recreational participation, might impact on injury recognition and treatment, are explored. The paper highlights the need for further research into those areas, and the need to immediately address the apparently low levels of awareness of If in Doubt. With that in mind, proposals for both immediate and longer-term reform for its dissemination are introduced.


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A survey of fungal succession on decomposing Bauhinia purpurea L. leaves in the unpolluted Tai Po Kau Forest Stream (TPKFS) and the animal waste polluted Lam Tsuen River (LTR) was carried out durin...


This study was attempted to test the fo11owing hypotheses. Those who have high need for achievement (High n Ach group) would show a greater learning effect on motor skill tasks than those who have low need for achievement (Low n Ach group). In the process of rnotor ski11 leaming, the High n Ach group would have higher task motivation, more strategies, and clearer imagery than the Low n Aeh group. The High (n=15) and Low (n=15) n Ach groups were screened frorn a total sarnple of 162 male undergr:aduate students on the basis of their responses te the Mehrabian Measure of Achieving Tendency. A rotary pursuit tracking was employed as a motor learning task. For the training session, the subjects were given 50 30-sec. trials with 15-sec. intertrial rests. Following 5 min. rest, 5 trials were treated as'the test session with the same procedure of the training session. The task motivation questionnaire, the checklist of strategy and the vividness test of imagery for this task were administered in the process of motor skill learning. In comparison with the Low n Ach group, the High n Ach group showed significantly higher scores on the time on target, the task motivation questionnaire and the vividness test of kinesthetic imagery. These results supported the hypotheses in this study. Therefore, it was concluded that the High n Ach group had a greater 1earning effect on the motor slcil1 task than the Low n Ach group, and the superiority for the High n Ach greup could have resulted from the strong task motivation at this task. However, there were no distinct differences between the two groups concerning the nurnber of strategies. Further investigations into this problem must be conducted in consideration of behavioral and cognjtive aspects of the leaming $trategy. (Tamotsu Nishida, "The effect of achievement motivation on motor skill learning -concerning a rotary pursuit tracl[ing-"JizP. J ?hys. Educ., 29-1 : 15-23, June 1984) 1 Ntrgepa Ch,itmsity, Rescarch Cbuter ofHtalth, Physiml 1Yhtess a,id Spa,ts. 1berocha Chihasa-k", Nagt})4a "64J


Foreword by Paul Tudor Jones. Preface. Chapter I. Chapter II. Chapter III. Chapter IV. Chapter V. Chapter VI. Chapter VII. Chapter VIII. Chapter IX. Chapter X. Chapter XI. Chapter XII. Chapter XIII. Chapter XIV. Chapter XV. Chapter XVI. Chapter XVII. Chapter XVIII. Chapter XIX. Chapter XX. Chapter XXI. Chapter XXII. Chapter XXIII. Chapter XXIV. Appendix: Dow Jones Industrial Average (1985-1929). Paul Tudor Jones on Reminiscenses. Selected Quotes. Credits. About the Author.


In his Institutio (11.3.85–88), Quintilian divides all human gestures into "imitative" and "natural," with natural gestures forming a symbolic code comparable to spoken language. This language of gesture would have included hand movements equivalent to adverbs, pronouns, nouns, and verbs. Such symbolic gestures, spontaneously accompanying words, were the only ones that Quintilian recommended for the orator.The actor's gestures, dependent as they were on the lines spoken — and not on the actor's thoughts and feelings — could not be spontaneous. The gestures made on stage were imitative of the various categories of the natural (i.e. symbolic) gestures, or of actions of everyday life.


Oxygen consumption, ammonia excretion and phosphate excretion rates were measured on the aggregate form (aggregated sexual blastozooid generation) and solitary form (solitary asexual oozooid generation) of Salpa thompsoni sampled from waters off the Antarctic Peninsula from December 1999 to February 2000, in conjunction with body composition analysis (water, ash, carbon, nitrogen and phosphorus). The specific metabolic rates of S. thompsoni were weightindependent. No significant differences between the aggregate and solitary forms were observed for the weight-specific rates with the exception of the oxygen consumption rate on phosphorus weight. Metabolic loss estimated for the aggregate and solitary forms was 3.0 and 3.5% day � 1 for body carbon, 1.6 and 1.8% for body nitrogen, 3.9 and 10.6% for body phosphorus, respectively. Contents of carbon (6.0% of dry weight for the aggregate form and 5.1% for the solitary form), nitrogen (1.5 and 1.3%) and phosphorus (0.15 and 0.11%) tended to decrease with the increase of dry weight. All mean values of each body constituent (water, ash, C, N and P) for the aggregate and solitary forms were not significantly different in the same dry weight ranges.


This is a preliminary report on 81 patients with cancer of the urinary bladder treated between June 1951 and June 19.58 with two-million-volt x-rays by the rotation technic. Material and Methods A total of 91 patients came for supervoltage irradiation. Eleven patients were excluded from consideration in this series (Table I) because they received no irradiation. All other cases were included. whether they received "curative irradiation" or "palliative irradiation." The patients were referred by many urologists and 75 per cent had been subjected to numerous surgical procedures of different types for successive lesions. By the time supervoltage therapy was started, most lesions were advanced, and the bladders, scarred by previous fulgurations and segmental resections and infiltrated with tumor, were not well able to tolerate intensive irradiation. Even the low-grade lesions in this series, Stages A and B1 , were extensive (Fig. 15). Thus we had the opportunity to observe the effect of supervoltage irradiati...


In this paper upper-bounded estimation of streaming rate for P2P streaming system is evaluated. Theorem proving adduced in case with different nodes download and upload rates.


Objective To describe the prevalence of, and degree of distress caused by, 15 symptoms commonly attributed to the menopause among a random sample of women aged 45 to 54, selected from the total population of a geographically defined area.


The present paper describes a new active method for controlling vortex shedding from a circular cylinder in a uniform flow at medium Reynolds numbers. It uses rotary cylinder oscillations controlled by the feedback signal of a reference velocity in the cylinder wake. The effectiveness of this feedback control is evaluated by measuring the response of mean and fluctuating velocities in the cylinder wake, the spanwise correlation, the power spectrum, and the fluid forces acting on the cylinder. It is found that the velocity fluctuations and the fluid forces are both reduced by the feedback control with optimum values of the phase lag and feedback gain. The simultaneous flow visualization synchronized with the cylinder oscillation indicates the attenuation as well as the mechanisms of vortex shedding under the feedback control, which is due to the dynamic effect of cylinder oscillation on the vortex formation.


It is well known that carriers of astrophysical information are massless spinning particles. These carriers are photons, neutrinos and, expectedly, gravitons. All these particles are emitted during supernova events. Information carried by these particles characterize their sources, but such information are affected by the trajectories of the carriers. Recently, it is shown that these trajectories are spin dependent. Knowing these trajectories and the arrival times of such particles to the detectors, a spin dependent model is constructed and compared with the conventional spin independent model.


A slide rule which allows the usual calculations connected with the use of radon to be carried out is described and examples for use are given.


Abstract : The oxidation of 5-hydroxytryptamine (5-HT) by pig serum was studied. Fractionation of the serum proteins showed that 5-HT is not a substrate of the amine oxidase present in the serum; its oxidation is catalysed by caeruloplasmin, the copper-containing protein of plasma. (Author)


Treatment failure in T-cell acute lymphoblastic leukaemia (T-ALL) occurs when leukemic blasts acquire resistance to chemotherapeutic agents. Current research efforts are focused on the search for targets for the development of more effective and less toxic anti-leukemic drugs. CD47 has been suggested to be involved in chemo resistance and cell metastasis. Although several potential mechanisms were suggested to explain the therapeutic effect of CD47-targeting; the different effects by CD47 are still not well understood. In this study, we assessed the effect of doxorubicin on CD47 expression in jurkat T cells. Jurkat cells in complete medium were cultured with doxorubicin (50-1000nM) or control for 0, 24, 48 and 72 hours. Cells were stained with anti-CD47 FITC. Flow cytometry analysis was used for measurement of fluorescence intensity. Cell viability was detected using trypan blue exclusion test. Treatment with doxorubicin modulated the up-regulation of CD47 on membrane surfaces of jurkat cells with no significant killing of the cells. leukaemia cells exert their anti-apoptotic role through increased CD47 expression. CD47 is a novel functional protein in jurkat T cells with promising therapeutic potential and may provide insight for targeted therapy against T-ALL disease.


Fast and precise fault categorization, location estimate, and fault detection are crucial because persistent faults can interrupt the power supply. The power outage zone will extend to nearby areas after the fault incident. Accurate and prompt fault identification is required for a power system to return to a healthy state. Protection, fault detection, diagnosis, identification, and localization are essential for efficient working of power system. Transmission line(TL) extensions are necessary due to rising industrialization and power demand, which greatly increases the complexity of the power system network. Analysis of faults in this intricate network becomes challenging. This paper reviews the latest machine-learning methods used for the identification and classification of faults in power systems.


AIM: To observe the effects of Pingzhi capsule on blood lipids and blood rheology in rodents. METHODS: Experimental hyperlipemia models were used in the study. Indexes of blood lipids, organ lipid and blood rheology were measured by enzymatic reaction and histochemistry methods and blood pressure was also observed. RESULTS: Pingzhi capsule 0.4 and 0.8 g/kg markedly reduced the body weight, liver coefficient, liver and serum cholesterol (TC) in hyperlipemia mice TC ( P 0.01). Pingzhi capsule markedly reduced body weight, coefficients of liver, heart and aorta,serum TC, serum triglyceride (TG), organ (liver, heart and aorta) TC and TG, the blood viscosity (high and low), plasma viscosity, and the whole blood specific viscosity ( P 0.01 ) of hypertension hyperlipemia rats. The serum high density lipoprotein cholesterol (HDL C) was elevated after the use of capsules ( P 0.01). CONCLUSION: Pingzhi capsule is effective in reducing blood lipid, blood viscosity, blood pressure, and organ TC and TG in both experimental hyperlipmia mice and hypertension hyperlipmia rats.


FIELD: power industry. SUBSTANCE: invention relates to power engineering. invention relates to power engineering. A heat storage system containing many storage tanks in which agent for storage of hidden heat is contained, as well as a piping system with supply pipelines for heat supply to storage tanks, delivery pipelines for heat removal from storage tanks, and a control module that is connected to one or more valves of the piping system. EFFECT: invention allows creating an effective heat storage system. 13 cl, 1 dwg


ican counterpart, relied on such tenets as an original contract, the authority of migration, and the right to isonomy, or equality in imperial rights. It also assumes, without demonstrating, that the Anglo-Irish elite employed traditional and natural law arguments side by side even though the parallel issue continues to generate controversy among American constitutional historians. Such quibbles, however, are perhaps inevitable for a work attempting to fill a longstanding void. No initial attempt can possibly cover every base or explore every angle. More important is what York does accomplish. Fifteen years ago, J. G. A. Pocock declared that "we must add the Anglo-Irish relationship" to complete our understanding of eighteenth-century politics, ideology, and constitutionalism in the English-speaking world ("1776: The Revolution Against Parliament," in J. G. A. Pocock, ed., Three British Revolutions: 1641, 1688, 1776 [Princeton, 1980], 267). Neither Kingdom Nor Nation is a valuable and significant first step toward that end, one that deserves a wide readership. As such it should ideally prove to be a catalyst for further work in the field. Until that happens, and doubtless well afterward, York's study will be indispensable for any student of the period seeking the understanding of which Pocock wrote.