Phillip Hamilton's edited collection of the letters of Lucy and Henry Knox during the American Revolution seeks to correct what he sees as a surprising lack of scholarship on the couple. Positioning the Knoxes' correspondence as an alternative to the better-known and oft-cited letters of John and Abigail Adams, Hamilton contends that the Knoxes' wartime exchanges offer an overlooked and accessible window into the American Revolution. Unlike the Adamses, the Knoxes were young (18 and 24 respectively), childless (at least at the start of the conflict), and newly married. Henry Knox was an officer in the Continental Army. Lucy Flucker Knox came from a prominent loyalist family, and split with her parents and siblings over the conflict. The Knoxes' wartime correspondence, Hamilton asserts, therefore not only speaks to the wartime hardships of revolutionary couples, but offers perspectives on the daily workings of the Continental Army, military encounters, and loyalist families. The edited volume contains 104 letters (29 by Lucy and 75 by Henry) from the Gilder Lehrman Collection. Spanning the ten-year period from their courtship in Boston in 1773 through the end of the war in 1783, the annotated letters are largely unaltered, except for minor corrections. The volume includes the entirety of Lucy's surviving wartime correspondence, and Hamilton selected Henry's letters both for their discussions of important events and "their direct engagement with Lucy's experiences and feelings" (8). Hamilton has organized the letters in five chronological sections, each of which contains a brief introductory essay situating the Knoxes within broader military and political contexts and highlighting pivotal moments in the couple's evolving relationship. The letters tend heavily toward the early years of the war, as after the Philadelphia Campaign of 1777, Lucy Knox traveled more frequently to military encampments. Hamilton's annotations are impressively detailed and reveal the extent to which he immersed himself in the Knoxes' lives and social relationships. Hamilton joins a recent group of scholars who are reconsidering the American Revolution. This historiographical turn has reinvigorated


Abstract: This paper reports the preliminary results of a study of universitybusiness collaboration in education in Sweden. At seven higher education programmes, associated external stakeholders, mainly in advisory boards or similar, have been interviewed. The focus for the interviews has been to explore the external stakeholders' ability to have an impact on the development of courses and programmes and their perceived role in the quality assurance process. The preliminary results of the study are mainly twofold; firstly, the diversity of the nature (settings, traditions, the ability to have an impact, etc.) of the seven different collaboration cases are immense and hardly comparable, secondly, the collaboration in the cases with mandatory internship (nursing education, teacher education) revolves almost exclusively around the internship periods. A preliminary conclusion is that the external stakeholders in the study are not aware whether they are a part of a systematic quality assurance process or not.


Hegels concept of spirit is the synthesis of the Kantian distinction between noumenon and phenomenon. Aesthetics, rooted as it is etymologically in the sensate and in feeling, is primarily concerned with matter, or in the calculated arrangement of symbols, which are in themselves material. The image in the brain has its own reality, but the image in the mind has a permanent quality, it can be fixed in the memory, though it can be made to alter. Cerebral information is of two sorts: potential and fixed. A lot of organized energy in the unconscious is archetypal. The mind has the advantage of being biological and ethereal as well as being electronic and mineral. The Forms in the mind are evolving.


The present invention discloses a high-speed one-way valve nested. The present invention also discloses a shock absorber comprising a high-speed one-way valve is nested, the shock absorber comprising: a valve assembly during a compression stroke of the compression function, acting during the rebound stroke and a rebound valve assembly compression valve assembly and a rebound valve assembly in a series of two or velocity sensitive valve. Said compression valve assembly, said valve assembly and the rebound velocity sensitive valve can be incorporated into the piston assembly, or incorporated into the base valve assembly in both.


This issue concerns plant breeding, with biotechnology at its beginning and progress, if it is seen as the "new green revolution," emphasizing the brazilian agricultural biotechnology and its development related to the leadership of the Brazilian Agricultural Research (EMBRAPA), considering the possible risks to both the environment and human health, respecting and practicing the laws and rules of biosafety. Also reports issues of Microbial Genetics, Microbiology and Molecular Biology in order to clarify various techniques of gene cloning, ranging from the choice of features aimed at improving a particular product by the process of isolation and transformation of these genes, using the most modern technologies.


A foundation in Korea invited poets from around the world to gather for a conference on peace in the summer of 2005. The undertaking seemed less quixotic and more practical after I learned a little about the figure from whom the Manhae Foundation takes its name. In Manhae (born Han Yong-un), Koreans can celebrate a great modernist poet who is also a central figure in Korean religion, culture, and politics. An American poet reads with some astonishment that Manhae, a monk and religious reformer who profoundly influenced Buddhist thought and practice, was also a coauthor of the Korean Declaration of Independence. Accomplishments comparable to those of Thomas Jefferson, Walt Whitman, and Ralph Waldo Emerson, achieved by someone born in 1879 (the same year as the American businessman-poet Wallace Stevens). This unusual, comprehensive centrality of Manhae may tempt even Western poets to feel some tiny glint of reflected glory. It also intimidates us: what can one offer in the context of such an imposing model? At that gathering in Seoul, where poets from around the world were invited to think about the somewhat vague ideal of peace, the challenge was perhaps the more poignant for


This paper puts forward a prototype process for the development of educational multimedia materials, which can help educational multimedia software developers produce more coherent and effective learning resources by making explicit the value/belief system on which the project is founded. The prototype is presented as an object and stimulus for debate and discussion, around the many issues it raises.

The paper critically reviews some current models of educational multimedia software development with regard to the role of "values/beliefs" and discusses why there is a need for these factors to be taken into account. It particularly focuses on environmental issues and is more widely applicable to those subject areas which involve the teaching of "controversial issues".

The basic process put forward involves three steps: 1) identifying and agreeing a prioritized list of the core values and beliefs on which the project is based 2) using these to inform the specification/design process 3) using them as part of the evaluation/quality control process. The process is illustrated using a small number of examples and the paper ends by looking forward to a full trial of the prototype and suggestions for further work.


In the main current of Mahayana Buddhism the Pure Land school took its form as a most practical way of realizing the Buddhist ideal. Though having a phenomenal, relative aspect of being born in Amida's Pure Land, it ultimately aims at the realization of the indiscriminate, absolute truth Tathata, or Thusness. These two aspects of relative and absolute, phenomenal and noumenal, are recognized throughout Mahayana Buddhism. The presence of this characteristic in the Pure Land ideology was already pointed out in China by a distinguished master, T'an-luan. In explaining in his (1) Wang sheng lun chu the term 'birth' (in the Pure Land), he showed emphatically that 'birth' is in essence a dependently originated phenomenon and that it is identical with 'non-birth'. His successor Tao-ch'o clarified in (2) his An lo chi that when we say 'desire for birth' we mean the desire for birth in the 'phenomenal' Pure Land but the Pure Land is in itself 'nonphenomenal' and transcendental. The point of their insistence is that the deluded ordinary men living in the sphere of relativity and phenomenality have no other means but to aspire for birth in the phenomenal Pure Land. In the Chinese Pure Land Buddhism this phenomenal, relative nature in the practical method of attaining the final goal was made clear against other schools, on one hand, and, on the other, it was recognized as the intrinsic characteristic of Amidism. In Japan such a problem as how to conceive of the 'Pure Land ide-


Voxel-based technology has already been present in the early years of computer visualization. However its usage was almost entirely confined to the field of medical image synthesis. Due to the continuous development of the CPU and graphics hardware, its role has increased again nowadays. It came to the fore especially in the field of computer games because of its specific properties. This publication presents a simplified visualization model and optimization techniques, which are able to visualize smaller (perhaps animated) voxel sets in real-time with certain compromises. The objective of the solution is not to reach the level of photorealistic image synthesis, but a provide a well applicable and simple method which can be applied for computer games and other graphical applications


Since the end of the Cold War the academic field of peace and conflict studies has flourished. These years have also seen the establishment of a great many local, national, and international nongovernmental organizations (NGOs), whose mission is to put theory into practice and address conflicts of all kinds. They have worked at every level, from communal to national and sometimes regional, and have built a substantial body of experienced-based knowledge through networks established to learn from practice.


A knowledge of the resistance to flow of a body placed in a stream of fluid is necessary for many problems in hydraulics, aeronautics, and ventilation. A large amount of experimental and theoretical effort has been expended investigating the drag characteristics of single bodies and small groups of similar bodies. Only a small amount of incomplete data is available regarding the performance of a long series of similar obstacles. This latter material was obtained for air flowing past supporting timber sets in mines. Since the dimensions of the mine shafts varied at different sections, the results of the experiments merely indicated the possibilities of obtaining different pressure losses depending on the size, shape, and spacing of the timber sets. Therefore, more data are needed regarding the drag characteristics of long series of obstacles.


Thermoplastic elastomers have been successfully used as impact modifiers for thermoplastics. Dynamic mechanical properties and phase transitions are very important for their application. In this paper, the copolymers high-impact polystyrene, PS-HI, styrene-ethylene/butylene-styrene block copolymer, SEBS, and their blends PS-HI/SEBS were investigated. Rheological behaviour of those samples during processing was followed by measuring the torque vs. time in the extruder Haake Record 90. The investigations were done by DMA analysis. The primary viscoelastic functions, the storage modulus, E', the loss modulus, Ě, and loss tangent, tgδ, were determined in the temperature range -150°C to 160°C. The correlation of the processing parameters and primary viscoelastic functions with content of the hard, PS, phase were discussed.


Through the comparative analysis of circulation background, cause character and physical index between two regional snowstorm in Henan on Feb.9-10 and Mar.4-5. So a conclusion can be drawn: the cyclonic curvature on low level shear line spread eastly or the low pressure moved in east direction is the primary reason of the snowstorm; it also get the forecast index of these two different Typical snowstorm.


In this paper comparison of Reflector Antenna analyzing techniques based on wave and ray nature of optics is presented for an offset reflector antenna using GRASP (General Reflector antenna Analysis Software Package) software. The results obtained using PO (Physical Optics), PTD (Physical theory of Diffraction), and GTD (Geometrical Theory of Diffraction) are compared. The validity of PO and GTD techniques in regions around the antenna, caustic behavior of GTD in main beam, and deviation of GTD in case of near-in sidelobes of radiation pattern are discussed. The comparison for far-out sidelobes predicted by PO, PO + PTD and GTD is described. The effect of Direct Radiations from feed which results in feed selection for the system is addressed. Keywords—Geometrical optics & geometrical theory of diffraction, offset reflector antenna, physical optics & physical theory of diffraction, PO & GO comaprison.


Memory CD4 T cells provide strong protection against influenza A virus (IAV), but the mechanisms and cellular interactions critical for their antiviral impact are not well described. A more complete understanding of how memory CD4 T cells contribute to viral clearance could improve T cell-based vaccine strategies aimed at protecting against both seasonal and pandemic IAV strains. Here, we show that IAV-specific Th1- and Th17-polarized memory CD4 T cells, as well as memory cells primed by IAV, protect otherwise naïve mice against lethal IAV challenge. We systematically deconstruct this protective response utilizing mice deficient for B cells, T cells, or both, to reveal multiple, distinct mechanisms of protection. First, in the absence of other T cells, memory CD4 T cells synergize with B cells to provide protection that is dependent on neutralizing antibodies but independent of characterized CD4 T cell helper functions. Second, in the absence of B cells, memory CD4 T cells synergize with CD8 T cells to promote equivalent viral clearance. These mechanisms of protection are both fully independent of interferon gamma (IFNγ) production by memory CD4 T cells. Third, in the absence of both B and CD8 T cells, memory CD4 T cells directly control IAV. Strikingly, this direct control is critically dependent on IFNγ. These results support a central role for memory CD4 T cells in orchestrating and directly participating in distinct forms of heterosubtypic immunity against IAV.


Medical liability systems have been accused of increasing health expenditure insofar as they induce the practice of defensive medicine. Despite the large evidence on the role of medical malpractice liability, the identification of its causal effect on physicians' treatment decisions is a difficult task. In this paper we study for the first time in a controlled laboratory setting the effect of introducing the risk of being sued for medical malpractice on the provision of physicians' medical services. In our experimental sessions both medical and non-medical students choose how many medical services to provide for heterogeneous patients. We implement exogenous variations in the presence of medical malpractice liability and expected probability of being sued, and thus we exploit the within-subject variation in the provision of medical services to infer the causal effect of malpractice liability. Furthermore, we analyze the impact of malpractice liability under different physicians' payment methods, which allows us to discuss the interplay between medical liability and payment systems. Our behavioral data show that introducing malpractice liability pressure does lead physicians to choose a higher amount of medical services, regardless of the physicians' payment system. However, we also find that the payment system in which malpractice liability is implemented makes the difference under the societal perspective, with relevant implications for health policy.


Magnetic manipulation of droplets has emerged as a promising strategy to achieve several complex tasks ranging from targeted drug delivery and micro‐robotics to controlled chemical synthesis. Hence, proper control in creating magnetically responsive droplets is indispensable for successful implementation. Here, an impact‐based encapsulation technique is employed to create stable ferrofluid‐wrapped single‐liquid and compound droplets inside a water bath. Thereafter, a permanent magnet is used to manipulate the resulting encapsulated cargo and demonstrate its feasibility for various applications. The manipulations reported herein are underwater magnet‐assisted drop translation and coalescence of compound droplets. The release of the innermost cargo in the compound droplet is also experimentally demonstrated via magnetic actuation. Importantly, for the first time, magnetically controlled coalescence of ferrofluid encapsulated compound droplets containing water‐soluble species in a water pool is demonstrated. The non‐contact manipulation technique presented in this work promises significant implications for magnet‐assisted actuation technologies.


OBJECTIVE:
Prediction of the effects of some chemicals on children9s brain development
 BACKGROUND:
Piericidin is first identified as an insecticidal metabolite produced by streptomyces. It was soon found to be an irreversible inhibitor of mitochondrial complex I. Neurosphere is a culture system composed of free-floating clusters of neural stem cells as well as progenitor cells. Since neural stem cells can not be studied in vivo, neurospheres provide a method to investigate neural precursor cells in vitro. This allows the neural stem cells to form the characteristic 3-D clusters.
 DESIGN/METHODS:
Rat neural progenitor cells were isolated from rat embryos (E14) extracted from placental tissue. The supernatant was, then, transferred to a fresh tube and centrifuged at 1,000 g for 5 min. The pellet was placed in Hank's balanced salt solution cultured as free-floating neurospheres in a proliferation medium at 37°C with 7.5[percnt] CO. Differentiation was initiated by growth factor withdrawal in differentiation medium and plating onto a poly-d-lysine/laminin matrix. Neurospheres were cultivated in proliferation medium & exposed for 2 weeks to Piericidin at doses of 1 μM, 5 μM, and 10 μM in separate wells plus the control group as well.
For proliferation analysis, spheres were cultured in proliferation medium. After 0,4,5,11 and 14 days, sphere size was determined by software analyses. Diameter of each neurosphere was measured and exported to excel file further to statistical analysis. Viability was assessed by the Trypan Blue exclusion test
 RESULTS:
Piericidin had no effect on proliferation rate, meanwhile cells viability were significantly affected especially those exposed to the highest dose (10 uM) directly proportional to the time of exposure.
 CONCLUSIONS:
Prolonged exposure to Piericidin has no gross morphological changes, but may lead to focal lesions due to affection of specific neural cells.
 Study Supported by: Disclosure: Dr. El-Hawary has nothing to disclose. Dr. Rakha has nothing to disclose. Dr. Lotfy has nothing to disclose. Dr. Elgamal has nothing to disclose. Dr. Salama has nothing to disclose. Dr. Sobh has nothing to disclose.


The article discusses Jarosław Marek Rymkiewicz's late poetic series titled Six Poems for Orpheus
with the aim to explore the metapoetic dimension of these poems and the continuities between
them. Rymkiewicz wrote these poems within a time span of over ten years, hence their varied
historical and political contextual references. The article also identifi es the specifi c features of Rymkiewicz's
Orphism and addresses the possible meanings of both the Thracian poet's catabasis and
the romance with the nothingness on the part of the subject of Rymkiewicz's mini-cycle. It also looks
at the implications of the concept of blurring the line between death and life in Rymkiewicz's poetic
writing.


This paper presents an adaptive filtering technique for the health diagnosis of mechanical systems, based on the generalized harmonic wavelet transformation. Through selection of two wavelet level parameters, a series of sub-frequency band wavelet coefficients corresponding to equi-bandwidth vibration signals measured from a machine were constructed. The energy and entropy associated with each sub-frequency band were then calculated, and the band with the maximum energy-to-entropy ratio was chosen to form a band-limited filter for the vibration signals. Experimental studies using rolling bearings that contain structural defects have confirmed that, the developed new technique enables high signal-to-noise ratio for effective machine failure detection and health diagnosis.


Soviet intervention in Afghanistan clearly indicates the strategic implications of its location. The political instability in the region (rise of fundamentalism in Iran, Iran-Iraq War and so on) has added to this significance. Be that as it may, Afghanistan's situation can be expressed in terms of its susceptibility to external pressures and intense factionalism within the land-locked state's dynamic populations. This latter aspect had divided the country several times over. Afghan foreign policy, therefore, has been viewed in this perspective. The present article reviews the stated facts to highlight the geographical significance of the location and its impact on the foreign policy. Introduction of the armed forces in national politics (this formed an important element in the country's politics right from the beginning) has been the most conspicuous development; it determined the who's and what's of the government. Traditional pressure groups, despite retaining some of their old hold on the society, had given way to radical groups or factions, armed forces and insurgent elements. These penetrated various strata of the Afghan society. Since 1963, when political liberalisation and participation was introduced, disruptive tendencies gradually impinged on the state's activities. Generally, this was evident between 1963–73 and was particularly so after the 1973 coup, when the Monarchy was replaced by a republican regime under Daud. Both, the Armed Forces and the Communist Party were involved but were sidelined once power was secured. This change did not bring the expected transformations in the patterns of administration. The change was only in name and power was still concentrated with Daud who began to implement his own policies that emerged between 1953–63. The period of his first stint in power coincided wiih an aggravation of problems, political and economic, caused by a closure of transit facilities. However, this pause was fully exploited by the radical parties who gradually brought the dominant elements of the Armed Forces under their influence, so that, they were able to deliver a coup d'etat under the leadership of Tarakki in April 1978. The new regime was not able to maintain effective control over the political situation that for the next twenty months brought internal political instability to its height and compelled the Soviet Union to move (this was perhaps to protect its vulnerable southern underbelly). The period from April 1978 onwards, saw active non-cooperation, large scale desertions from the Armed Forces and a deterioration of the economy. In addition, open opposition by the religious groups and insurgent elements presented a political picture that has been so vividly illustrated by Afghan political history. Intense factionalism and infighting within the regime saw Amin replacing the moderate Tarakki in September 1979. This led to a worsening of the political situation with the state at war with itself. This compelled the Soviet Union to move into Afghanistan. In a short but bloody war, Amin was disposed and a government under Karmal was established with Soviet support1. These developments then, clearly suggest the need to review the background of the patterns and problems of the foreign policy of Afghanistan as determined and identified by its locational characteristics.


The invention relates to a method for calibrating a sensor measuring at least one bearing for a storage installation, are matched with the individual measured values of an individual bearing installation with representative reference values of a reference installation.


Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically heterogeneous heart muscle disease characterized by progressive fibrous-fatty replacement of right ventricular myocardium and an increased risk of sudden cardiac death. Mutations in desmosomal plaque proteins have been previously described to cause both autosomal dominant and autosomal recessive forms of ARVC. Therefore we hypothesized that mutations in the cardiac desmosomal cadherin, desmocollin-2 (DSC2) might cause ARVC in humans. We identified an A to G transition that affects the highly conserved 3′ splice acceptor site of intron 5 (IVS5–2A > G) of the DSC2 gene in a patient with ARVC diagnosed by the proposed Task force criteria. This splice acceptor site mutation in DSC2 led to the use of a cryptic splice acceptor site with a deletion of the highly conserved cell adhesion recognition (CAR) sequence and a creation of a downstream premature termination codon (PTC). Quantitative analysis of cardiac DSC2 expression in patient specimens revealed a marked reduction in the abundance (3%) of the truncated mutant allele at mRNA level, supporting possible nonsense-mediated mRNA decay. At protein level the wildype DSC2 expression was reduced when compared with control myocardium, suggesting that haploin-sufficiency may contribute to the disease mechanism for this mutation. To further evaluate the consequences of reduced cardiac DSC2 we cloned the zebrafish dsc2 gene, and studied zebrafish embryos with antisense morpholino knockdown of dsc2. These dsc2 knockdown embryos developed morphologic and hemodynamic features of myocardial contractile failure. Ultrastructural analyses of morphant hearts reveal reduced desmosomal plaque area and consistent loss of the desmosome extracellular electron-dense midlines. We conclude that DSC2 mutations can cause ARVC and demonstrate for the first time in vivo that physiologic levels of DSC2 are crucial for normal cardiac desmosome formation, early cardiac morphogenesis and normal cardiac function. The implication of desmosomal cadherin DSC2 as a new disease gene also extends the concept of ARVC as primarily a disorder of the cardiac desmosome.


Background: Clinical supervision (CS) provides nurses with an opportunity to improve quality of patient care in particular for a given patient and in relation to maintain standards of care. In addition, CS provides an avenue for nurses to demonstrate active support for each other as professional colleagues, and providing reassurance and validation. Aim:to assess first line nurse manager's clinical supervision at Minia University Hospitals. Setting: The study was carried out at Minia University Hospitals (Minia University Hospital; and Gynecology, Obstetric and Pediatric University Hospital) in Minia city. Subject:All available first-line nurse managers' were included in the study (total no 50 nurse) in Minia University Hospitals and all available staff nurses were included in the study (total no 300 nurse) in Minia University Hospitals. Tools:two tools were used in this study; Clinical supervision knowledge questionnaire, and Manchester Clinical Supervision Scale (MCSS). Results: more than three quarters (76%) of the first line managers had low knowledge about CS; and less than three quarters (70.6%) of nurses' perceptions about CS provided by the first line mangers was low level. Conclusions:First line managers had low knowledge about CS and nurses' perceptions about clinical supervision provided by the first line mangers was low level. Recommendations:First line managersneed program to increase theirknowledgeand performance about CS.


The plural organic whole "Law" asks us to analyze and grasp "the law"_ this social phenomenon from many aspects on the research of the law. The article analyzes the literal value of the law from such aspects as that literature is the means of passing on the law and the advocates of maintaining justice in order to explain reasonably the relationship between the law and the literature.


The present study focuses on the points of similarities and differences found in English, Arabic and Kurdish languages in terms of negation. The three languages belong to different families and they all exist in the researchers own country (Iraq). Arabic is spoken natively in the middle, the western and the southern parts. Kurdish is spoken natively in the northern part called Kurdistan Region. English is a foreign language in all parts of Iraq. All the three languages under study are taught as school subjects all over Iraq in general and higher education. Negation is dealt with in the three languages mentioned above in terms of word negation and sentence negation. Word negation discusses the way in which a word is negated, i.e., how prefixes and suffixes are used to reverse the meaning of the word an affix is added to. Sentence negation is dealt with in terms of how the affirmative declarative sentence is negated in all the three languages mentioned above. Findings show that negation in the three languages under examination is different parametrically.


Pinhole-free perovskite films with low defect density are essential to boost the efficiency of metal halide perovskite light-emitting diodes (PeLEDs). In this work, a novel amphiphilic silicone copolymer (Si14-PEG14-QAC) is introduced into perovskite as a passivation agent to improve the performance of PeLEDs. Si14-PEG14-QAC possesses polyethylene glycol and –NCH3 units, which can interact with perovskite by hydrogen bonding, resulting in high-quality perovskite films with small-size crystals, high coverage, low defect density, and enhanced photoluminescence quantum yield. Consequently, the perovskite films with Si14-PEG14-QAC enable efficient green PeLEDs with an external quantum efficiency of 4.5%, which is much higher than that of the control device without the polymer passivator (0.86%). This work suggests the great potential of silicone copolymers as passivation agents for high-quality perovskite films with high performance.


Hidradenitis suppurativa (HS) is a challenging disease to treat; however, a better understanding of the disease and continued research has led to more clear-cut therapeutic options, according to an expert who spoke at the North American Clinical Dermatologic Society meeting.


Objective To evaluate the significance of joint detection of matrix metalloproteinase-9 (MMP-9) and low-density lipoprotein-C (LDL-C) on the danger degree assessment of coronary artery disease (CAD). Methods Detection of MMP-9 and LDL-C in serum level was performed in 30 patients with stable angina pectoris (SAP), 20 patients with acute myocardial infarction (AMI), 30 patients with unstable angina pectoris (UAP) and 30 age-matched individuals with negative angiographic findings. Results The serum level of MMP-9 was remarkably increased in the patients with acute coronary artery syndrome (ACS) when compared with that of SAP and normal control group (P<0.05). The serum level of LDL-C was remarkably increased in the patients with coronary artery disease (P<0.05). The serum level of MMP-9 of the patients whose LDL-C level was higher than normal was much higher (P<0.05). Conclusion Joint detection of MMP-9 and LDL-C may be helpful to assessing danger degree of coronary artery disease. In this way, we can find and cure CAD patients at high risk earlier.


Presented through the nostalgic prism of her absence, Nabokov's heroine is a poetic vessel of a male character's journey. Barely trusted with any lines, not to mention internal monologues, she is essentially mute. In the best tradition of the Russian mermaid fairy-tales and films, she seems to have traded her voice for human form in order to be close to her beloved, but, misunderstood and unable to fit in his world of mortals, she ends up leaving forever, as he mourns the loss of his one chance at happiness. As if in return for such an arrangement of circumstances, Nabokov's mermaid-like woman is granted a brief access to the otherworldly dimension, which she in turn feminizes and charges with her presence. This magical, if hardly fair, exchange can be observed in "Spring in Fialta." The first part of the article traces the русалка -mermaid watermark through Nabokov's creative work. The second reads "Spring in Fialta" through the lens of the русалка belief and the Russian folk wedding lamentation ritual ("свадебное причитание") -two intertwining motives, each carrying funereal overtones, which so far have been left unexamined by the critical literature.


(L)-Phenylalanine 4 can be converted to N-(4-methyl-3-pentenyl)tetrahydrosisoquinoline-3-carbaldehyde 10 and the corresponding homologous aldehyde 19 in 4 and 5 steps, respectively, by employing the Pictet–Spengler reaction as the key step. After Lewis acid catalyzed cyclization of 10 and 19 the cis-configured 1-hydroxybenzo[b]quinolizidine 21a and 11-hydroxyazepino[1,2-b]isoquinoline 22a were obtained with high diastereoselectivities. Compound 21a, which was characterized by X-ray structure analysis, displays a fishbone pattern of endless zig-zag chains connected via intermolecular hydrogen bonds in the solid state.


The management including daily maintenance and managing system in Molecular Medicine Laboratory is studied. Measures and rules are proposed. These proposed measures and rules not only can be used as references and examples for management staff in education institutes, but also can improve the standardization management, extent and use efficiency of equipments.


Objective To determine the utility of diffusion-weighted magnetic resonance imaging ( MR DWI ) in detecting tumor necrosis with histological correlation after neoacljuvant chemotherapy. Methods Conventional MRI and DWI were obtained from 36 patients with histological proven esteosarcoma. Magnetic resonance examinations were performed in all patients before and after 4 cycles of preoperative neoadjuvant chemotherapy. Apparent diffusion coefficients (ADC) were calculated. The degree of tumor necrosis was assessed using the histological Huvos classification after chemotherapy. T-test was performed for testing changes in ADC value between the 2 groups. P value less than 0. 05 were considered as a statistically significant difference. Results The differences in ADC between viable [ (1.06±0. 30) ×10-3mm2/s ] and necrotic [ (2. 39±0. 44 )×10-3mm2/s] tumor were significant (t= 3. 515,P<0. 05). Changes in ADC value was greater in good responses to neoadjuvant chemotherapy than in poor responses, the ADC value in good responses was increased from (1.18±0. 19)×10-3mm2/s to (2. 27±0. 20)×10-3mm2/s, the corresponding value in poor responses was increased from (1.45± 0.11)×10-3mm2/s to (1.83±0. 16)×10-3mm2/s, There was significant difference in changes of ADC values between good responses and poor responses ( t = 4. 981, P < 0. 01 ). Conclusion Diffusion-weighted MRI permits recognition of tumor necrosis induced by chemotherapy in osteosarcoma. DWI is correlated directly with tumor necrosis. They have potential utility in evaluating the preoperative chemotherapy response in patients with primary osteosarcoma.

Key words:
Osteosarcoma;  Drug therapy;  Diffusion magnetic resonance imaging


Venovenous extracorporeal membrane oxygenation (VV-ECMO) has been used as a rescue therapy for patients with refractory coronavirus disease (COVID-19)–associated severe acute respiratory distress syndrome (ARDS) with survival rates similar to those reported for ECMO support of ARDS of other causes (1, 2). However, the need for prolonged ventilation, sedation, and immobility may limit long-term benefits of ECMO in these patients. Specifically, they are exposed to a high risk of ventilator-associated pneumonia (3). According to a recent case series, single-access, dual-stage VV-ECMOwith extubation on ECMO (median time to extubation: 13 d) appeared to be safe and associated with a favorable prognosis for patients with severe COVID-19–associated ARDS (4). VV-ECMO has anecdotally been applied as an alternative to invasive mechanical ventilation (MV) in awake, spontaneously breathing patients with ARDS caused by Pneumocystis pneumonia (5) or immunocompromised status (6). We report herein a patient with COVID-19, with severe ARDS not responding to high-flow nasal oxygen and noninvasive ventilation (NIV), who was successfully treated with prolonged "awake ECMO," thereby avoiding endotracheal intubation andMV. OnNovember 5, 2020, a 57-year-old man (bodymass index, 29 kg/m) was admitted to our department 3 days after COVID-19 symptom onset. His oxygen saturation was 40% on room air and increased to 90% with 15 L/min of oxygen via a facemask. Real-time RT-PCR of his nasopharyngeal swab was positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Figure 1). His medical history was marked by chronic hypertension and coronary artery bypass surgery with preserved left ventricular function 26 days before admission. He had been discharged from the hospital 12 days after cardiac surgery. At ICU admission, he had signs of acute respiratory failure. Initial therapy consisted of high-flow nasal oxygen (50 L/min; FIO2, 100%) and dexamethasone (7). He did not require inotropes or vasopressors. On Day 5, he became tachypneic (respiratory rate. 35/min) and required continuous NIV for adequate oxygenation (V_ E, 28 L/min; positive endexpiratory pressure, 6 cm H2O; FIO2, 100%). Blood gas values were as follows: PaO2/FIO2, 55 mmHg; PaCO2, 32 mmHg; and lactate, 2.3 mmol/L. Surprisingly, he did not complain of intense dyspnea. Chest X-ray showed extensive bilateral pulmonary infiltrates (Figure 2). Intubation was discussed with the patient, who adamantly refused because of bad memories of it after heart surgery. Then awake VV-ECMOwas proposed and he agreed. A 29F drainage cannula was inserted through the left femoral vein and a 21F return cannula into the right internal jugular vein under NIV, local anesthesia, and lowdose analgesia and sedation including 10 mg ketamine, 5 mg midazolam, and 10 mgmorphine. During the 41 days of ECMO support, femoral–jugular ECMO blood flow ranged from 3.5 to 5.7 L/ min and sweep gas flow from 2 to 6 L/min, with membrane O2 fraction set at 100%. The patient was comfortable with less tachypnea. He did not complain of dyspnea and, after Day 8, no longer required NIV. High-flow nasal oxygen (30–40 L/min) was maintained throughout the ECMO run to improve lung volume and lower hypoxic central drive (8). Chest computed tomography on Day 20 showed extensive bilateral parenchymatous condensations with traction bronchiectasis and no residual pulmonary embolism. Consequently, high-dose corticosteroids were initiated. On Day 24, Enterococcus faecalis infection of the jugular cannula and bacteremia were diagnosed and corticosteroids suspended. Because positive blood cultures persisted despite prolonged intravenous amoxicillin on Day 36 and the patient could not be weaned off ECMO, the return jugular cannula was removed and replaced by a right femoral cannula. Amoxicillin was maintained until Day 48 (i.e., 48 h after ECMOweaning). Notably, he experienced only one nosocomial pneumonia episode on Day 17 during his 48 days in the ICU. He performed active physical exercises daily in bed with a physiotherapist. On Day 18, he was able to stand up, with assistance. Oral feeding was maintained throughout his ICU stay, as was social interaction by phone or face to face with his relatives. Moreover, the patient was informed daily of his health status and medical decisions and was always able to express his preferences. OnDay 46, he was successfully weaned off ECMO (i.e., after 41 d). Forty-eight hours after ECMOweaning, the patient was able to walk around his bed and was cycling to a chair. He was discharged from the ICU to the Pulmonology Step-DownUnit on Day 51. He lost 7 kg during his ICU stay with serum albumin at 32 g/L at ICU discharge. He was discharged from the hospital and transferred to a rehabilitation center on Day 66 with oxygen 2 L/min at rest. At that time, his chest computed tomography showed significant regression of posterior basal, middle, and superior condensations, reticulations with the persistence of fibrosis features, and traction bronchiectasis (Figure 2). This "fully awake" ECMO strategy enables active treatment participation and ambulation andmight avoid complications associated with heavy sedation, paralyzing agents, and prolongedMV. Indeed, unlike data reported for patients with COVID-19 with long ECMO runs (1), our patient had only one episode of pulmonary bacterial superinfection due to oropharyngeal bacteria. Moreover, daily active mobilization limited ICU-acquired weakness and preserved This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/). For commercial usage and reprints, please contact Diane Gern (email@example.com).


The purpose of this paper is to determine the influence of the noninstrumental component of procedural justice on organizational commitment and whether this relationship is moderated by age. Regression analysis on a sample of 161 employees revealed that noninstrumental procedural justice had a significant effect on organizational commitment. The hypothesis concerning the role of age as a moderator was not supported. Implications for managerial practice and future research are discussed.


The United States Supreme Court has almost complete discretion over the cases it hears, so how does it decide which cases are worthy of its attention? The Court receives many signals from various actors indicating which cases are worthy of its attention. Many signals, including those sent by the federal government and various interest groups have been widely researched and have been demonstrated to increase the likelihood the Court will grant certiorari to cases when these signals are present. The signal sent by lower court judges through their dissents is the concern of this study. This study contributes to the literature by investigating whether the ideological proximity of the dissenting judge and Court median affects the likelihood the Court will review a case. This study uses the last three years of the Rehnquist Court and the first three years of the Roberts Court. During these six years, a sample of constitutional law cases petitioning for a writ of certiorari is randomly selected and coded for dissent and other factors. Some of the other factors coded for: federal government involvement, amicus briefs and saliency, among others, when present, have previously been shown to increase the probability that cert will be granted. This study analyzes whether the presence of a lower court dissent affects the probability that the Supreme Court will grant certiorari to constitutional law cases. In order to hold the type of signal that could be sent as constant as possible only cases decided by three-judge panels in federal circuit courts are considered in this study. The hypothesis of this study is that the presence of a lower court dissent increases the likelihood that the Supreme Court will grant a writ of certiorari. This study also hypothesizes that the smaller the ideological distance between the dissenting judge and the Court median, the greater the likelihood the Court will grant certiorari. This study finds that dissent enhances the likelihood the Court will grant certiorari but the ideological proximity and partisanship of the dissenter does not influence the Court's decision to grant review.


This article updates the general neurosurgeon on the current issues and contro-versies in craniofacial surgery. Topics discussed include differential diagnosis of posterior plagiocephaly, timing of craniosynostosis surgery, technical advances, intracranial pressure in craniosynostosis, and new technologies.


DURING THE SUMMER and early fall of 2003, U.S. military forces conducted stability operations and support operations (SOSO) in Liberia to help prevent an impending humanitarian disaster. Conducted in an uncertain security environment, this joint and combined operation involved U.S. land, air, sea, and special operations forces (SOF) and the military forces of eight West African countries. This is the story of how a relatively small U.S. force using reachback technology and intensive interagency coordination helped an untried West African force secure the Liberian capital of Monrovia for the resumption of humanitarian operations. In July 2003, Liberia was in the death throes of a 23-year civil war. Under attack on two fronts, Liberian President Charles Taylor's government forces prepared for the final defense of the capital. Desperate for security and food, thousands of Liberian civilians flocked to camps established for "internally displaced persons." In addition to the obvious need to prevent human suffering, the United States wanted to reduce the risk of Liberia becoming a source of regional instability. However, it was critically important that the United States not be drawn into a mission of unlimited duration while demonstrating its support for the Liberia peace process, because the U.S. military was already stretched thin because of the Global War on Terrorism. The U.S. military presence in Liberia was an economy of force operation. The Liberian Crisis Liberia was established by freed American slaves in 1847. Although it had once been a prosperous nation, it began to spiral downward after Samuel Doe's bloody coup in 1980. Charles Taylor, the charismatic but corrupt president of Liberia, came to power in a questionable election in 1997. Under UN indictment for alleged war crimes in Sierra Leone, Taylor was preoccupied with his own war against two rebel factions: Liberians United for Reconciliation and Democracy (LURD) and the Movement for Democracy in Liberia (MODEL). Through the first half of 2003, short but violent engagements characterized the fighting between rebel and government forces. Roving bands of armed fighters, many high on drugs, preyed on defenseless civilians. Both sides employed thousands of child soldiers. The collapse of security in Monrovia forced the UN and other humanitarian organizations to leave the country. By late July, thousands of frightened civilians streamed toward the capital in search of food and safety. In March 2003, U.S. European Command (EUCOM) began intensely monitoring the situation in Liberia. With the situation continuing to deteriorate, EUCOM dispatched a survey and assessment team and a U.S. Navy SEAL platoon to Monrovia. In early July, EUCOM bolstered embassy security with a Fleet Anti-Terrorism Security Team Platoon. EUCOM also deployed a humanitarian and assistance survey team to determine the extent of the humanitarian crisis. In mid-July, EUCOM pre-positioned the 398th Air Expeditionary Group in Freetown, Sierra Leone, and Dakar, Senegal. EUCOM also placed SOF in neighboring countries, in preparation for a possible noncombatant evacuation of U.S. citizens. On 17 July, the U.S. Army Southern European Task Force (SETAF) (Airborne), under the command of Major General Thomas R. Turner, received warning orders from EUCOM and U.S. Army Europe to establish a joint task force (JTF) by 25 July. Organized and manned as the core of a JTF headquarters, the task force's practiced JTF procedures, and the reachback capabilities of its command and control (C2) facility near Vicenza, Italy, made it well suited to lead the military effort in Liberia. Manning proved to be one of the most challenging aspects of forming the JTF. SETAF used EUCOM Directive 55-11, "Joint Task Force Headquarters, Policies, Procedures and Organization," as the base document for building the Joint Manning Document (JMD). However, delays in filling the EUCOM-validated JMD affected the initial planning effort. …


Resembling lipstick,Lidocaine Stick (LS) is used for pinpoint anesthesia of the skin prior to invasive procedures in dermatology or plastic surgery treatments,and has been shown to produce a quick and sustained anesthetic effect.We designed a formula and preparation method for LS,and evaluated its anesthetic effect by conducting a prick test in volunteers and a clinical study in patients undergoing pimple excision.We were able to design a surfactant-containing oily formulation for LS and a preparation method for it.The results of the prick test indicated that the anesthetic effect of a 60% LS was comparable to that of a commercially available tape preparation containing the same volume of lidocaine.In the clinical study on patients undergoing pimple excision,the 60% LS produced an anesthesia rate of 65.5%.Furthermore in a questionnaire survey,both volunteers and patients responded favorably with regard to the smoothness and ease of use of the 60% LS.


Developing interdisciplinary methods to measure ecosystem services is a scientific priority, however, progress remains slow in part because we lack ecological production functions (EPFs) to quantitatively link ecohydrological processes to human benefits. In this study, we tested a new approach, combining a process‐based model with regression models, to create EPFs to evaluate water storage and local climate regulation from a green infrastructure project on the Yongding River in Beijing, China. Seven artificial lakes and wetlands were established to improve local water storage and human comfort; evapotranspiration (ET) regulates both services. Managers want to minimize the trade‐off between water losses and cooling to sustain water supplies while lowering the heat index (HI) to improve human comfort. We selected human benefit indicators using water storage targets and Beijing's HI, and the Variable Infiltration Capacity model to determine the change in ET from the new ecosystems. We created EPFs to quantify the ecosystem services as marginal values [Δfinal ecosystem service/Δecohydrological process]: (1) Δwater loss (lake evaporation/volume)/Δdepth and (2) Δsummer HI/ΔET. We estimate the new ecosystems increased local ET by 0.7 mm/d (20.3 W/m2) on the Yongding River. However, ET rates are causing water storage shortfalls while producing no improvements in human comfort. The shallow lakes/wetlands are vulnerable to drying when inflow rates fluctuate, low depths lead to higher evaporative losses, causing water storage shortfalls with minimal cooling effects. We recommend managers make the lakes deeper to increase water storage, and plant shade trees to improve human comfort in the parks.


Nontuberculous mycobacteria (NTM) are opportunistic pathogens widely spread in the environment that may produce lifethreatening infections in humans. With the increased number of patients suffering from different forms of immunosuppression, there has been a resurgence in interest in NTM and increase in the prevalence of NTM diseases. Although the incidence of Mycobacterium kansasii infections shows significant geographical variability, in most places, M. kansasii ranks first as a cause of pulmonary NTM syndromes in the HIV-negative population and second as a cause of disseminated infection in HIV-positive patients. In Poland, among cases of NTM disease, the number of which has been remarkably on the rise in recent years, those attributable to M. kansasii are in majority. Many epidemiological aspects of M. kansasii infection, concerning the pathogen's reservoirs, contagiousness, transmission routes and distribution in different geographic regions and among different human populations, are unknown or only poorly understood. As with other NTM, M. kansasii infections are believed to be acquired from environmental exposures rather than by person-to-person transmission. Rarely M. kansasii has been isolated from soil, natural water systems or animals. Instead it has almost exclusively been recovered from municipal tap water, which is considered to be its major environmental reservoir. Culturing of M. kansasii from human tissues may not necessarily represent true infection but a non-pathogenic colonization or contamination. Thus, a reliable diagnosis of M. kansasii disease relies upon an in-depth clinical and laboratory investigation, requiring integration of symptomatological, radiological, and microbiological data. In thoracic imaging, M. kansasii infections may manifest as cavitations, opacities, small nodules and bronchiectasis, most frequently situated in the upper lobes, but lesions may also be present in other sites of the lungs. Treatment of M. kansasii infections is based on a combined and long lasting (at least 15 months) regimen consisting of ethambutol, isoniazid and rifampicin.


This contribution describes the evolution of the main CERN storage system, CASTOR, as it manages the bulk data stream of the LHC and other CERN experiments, achieving over 90 PB of stored data by the end of LHC Run 1. This evolution was marked by the introduction of policies to optimize the tape sub-system throughput, going towards a cold storage system where data placement is managed by the experiments' production managers. More efficient tape migrations and recalls have been implemented and deployed where bulk meta-data operations greatly reduce the overhead due to small files. A repack facility is now integrated in the system and it has been enhanced in order to automate the repacking of several tens of petabytes, required in 2014 in order to prepare for the next LHC run. Finally the scheduling system has been evolved to integrate the internal monitoring. To efficiently manage the service a solid monitoring infrastructure is required, able to analyze the logs produced by the different components (about 1 kHz of log messages). A new system has been developed and deployed, which uses a transport messaging layer provided by the CERN-IT Agile Infrastructure and exploits technologies including Hadoop and HBase. This enables efficient data mining by making use of MapReduce techniques, and real-time data aggregation and visualization. The outlook for the future is also presented. Directions and possible evolution will be discussed in view of the restart of data taking activities.


Organic vapors emitted from solvents used in chemical / food / pharmaceutical processes, or from hydrocarbon fuel storage stations at oil terminals, can be efficiently captured by adsorption onto activated carbon beds. The overall objective of the research program is the experimental and simulation studies of the adsorption and regeneration steps in the case of VOC removal which accounts into industrial emissions by Temperature Swing Adsorption (TSA) and Vacuum Temperature Swing Adsorption (VTSA) processes. This is achieved by the following steps : to establish the isotherm equilibrium data for 5 VOCs and 8 activated carbons at 293, 313, 333, and 353 K (totally 120 isotherm experiments) and then use them in the simulation model; to develop a simulation model for adsorption and regeneration process; to design and optimize the experimental setup of Thermal Swing Adsorption (TSA) which has been established in Ecole des Mines de Nantes; to design and optimize the experimental setup of Vacuum Temperature Swing Adsorption processes (VTSA) which has been established in GRL ARKEMA unit ; simulation validation of experimental results of TSA and VTSA process. Once after the completion of all the objectives, the goal is to develop and launch a complete simulation package for adsorption and regeneration steps of VOCs with the co-operation from PROSIM Corporation.


In raising some questions about age differences among American couples the 1st step will be to describe the trends and patterns in differences in age at marriage and age at parenthood in the U.S. The impact of these differences on the role participation of men and women both within and outside then family will then be considered. In this context the effort is made to assess the implications of differences in age between spouses for the status of women vis-a-vis men. Mostly secondary sources of data are used and consequently the discussion is speculative. Generally there is little change over the 1960-1970 decade in age differences between spouses. For about 3/4 of married couples in both 1960 and 1970 the husband is older than the wife. For about almost 1/3 of all married couples in both years he was 5 or more years older. There is then considerable dispersion in age differences between spouses. For most couples age differences at 1st marriage are equivalent to age differences at parenthood that is most couples have children when married and have their 1st child during their 1st marriage. The trend in age differnces between parents thus closely approximates the trend in age differences between spouses. It does appear that early marriage and early parenthood have a restrictive effect on nonfamilial roles more so for wives than for husbands. Additionally this effect may be greater the older the husband is relative to the wife. The answer to the question of why then do many women marry early and marry men who are many years older than they may lie at least in part in how the status of women is assessed by the woman herself and by the society. If the status of women is considered to be derived from men then it is mens achievements outside the family that are the primary sources of social prestige for women. Yet early marriage to a successful man may inhibit womens own achievements outside the family. Age differences between spouses may be regarded as less relevant for the personal status of women when couples marry late or remain childless.


Background and objectives:Recently, using of bipolar transurethral resection of the prostate has challenged the for- mal monopolar transurethral resection of the prostate. The aim of this study was to evaluate the efficacy and safety of bipolar transurethral resection of prostate versus monopolar transurethral resection of prostate in the treatment of prostate enlargement. Methods: From September 2018 to April 2019, appropriate sample of 44 patients with symp- tomatic benign prostate hyperplasia randomly assigned to two groups, first group (n=21) operated on by monopolar transurethral resection of prostate, second group (n=23) operated on by bipolar transurethral resection of prostate in Rizgary Teaching Hospital and Zheen International Hospital, all patients were fully assessed preoperatively and postop- eratively by serum electrolyte, hemoglobin, operative time. Results: Mean resection time was 56.7 ± 5.8 minutes (mo- nopolar) and 63.1 ± 4.7 minutes (bipolar). The mean volume of irrigant was 17.6±1.6 liter (monopolar) and 20.4±1.8 liter (bipolar). The monopolar group showed a greater decrease in serum Sodium (5.7mEq/L) in contrast to the bipolar group (1.4 mEq/L), a statistically significant difference was detected. The monopolar group showed a statistically significant decrease in Hb (2.5 gm/dl) in contrast to the bipolar group (0.4 gm /dl). Conclusions: T he study showed that bipolar transurethral resection of prostate was superior to monopolar transurethral resection of the prostate with regards to less reduction in serum Sodium level and less decline in hemoglobin level as well as less hospital stay and catheterization days.


It is true that originality is not that the man remains in living alone, but the originality is to evacuate the idea with the ideas of others, "The lion is not only several digestible sheep", but the renewal or development of heritage does not mean that the search for the originality or individuality turns to the romantic slogan, which sanctifies all the new for the sake of itself and looks at the values of things in their ages or affiliation to this age. Undoubtedly, the response to the spirit of the times is essential in the concept of development, but the romantic mantras: the (self) and (zeitgeist) without realizing the act of the past and its importance in directing the contemporary age is unacceptable. The renewal or development is not to repeat the old thinking or use an old drum always, but it is related to the greatness of heritage or culture needs the humanitarian effectiveness to highlight it, which is our responsibility. The recognition by all over the world cannot be without the inherent power within our message, which cannot be obtained from abroad. The renewal is the formation of a general cosmic perspective strikes in the depths of the heritage with its roots, overlooking with the branches of its present at all of its dimensions and requirements.


Abstract Disclosure: H.S. Kannangara: None. B. Jocoll: None. S. Miyashita: None. A. Gumerova: None. F. Korkmaz: None. R. Witztum: None. S. Sims: None. U. Cheliadinova: None. G. Pevnev: None. O. Moldavski: None. T. Frolinger: None. T. Yuen: None. V. Ryu: None. M. Zaidi: None. In addition to its well-known action to trigger thyroid hormone production, thyroid-stimulating hormone (TSH) is released in the brain, and its receptor (TSHR) has been found in brain sites, including the tanycytes of the third ventricle, that regulate ingestive behavior and convey metabolic information across the blood-hypothalamus barrier (BHB). Our recent work highlights largely undiscovered role for TSHRs in the tanycytes. Here, we tested the hypothesis that tanycytic TSHR activation triggers rapid remodeling of BHB vascular permeability inducing appetite. We compared hypothalamic vascular permeability of food deprived (FD) and ad libitum fed (AL) Tshr+/- and their wild type (WT) counterparts exploiting transmission electron microscopy studies and immunofluorescence for constitutive tight junction protein Claudin-1 and homodimer glycoprotein MECA-32, primarily expressed in tanycytes and endothelial cells, respectively. Fasting significantly increased the organization of tanycytic honeycomb pattern of Claudin-1 and fenestral MECA-32-associated diaphragms in the median eminence and arcuate nucleus implying decreased BHB vascular permeability in Tshr+/- mice. Transmission electron microscopy confirmed immunofluorescence results. In a separate gain-of-function experiment, TSHR activation by the small molecule MS438 increased BHB vascular permeability as evidenced by decreased Claudin-1 and MECA-32 immunostaining. Tanycytic TSHR activation significantly increased both food foraging and intake as during one-hour refeeding after FD. Surprisingly, refeeding restored neuronal activation marker c-Fos expression in the paraventricular nucleus of the hypothalamus, parabrachial nucleus and nucleus of the solitary tract, though failed to do so in the paraventricular nucleus and nucleus of the solitary tract of MS438-injected mice. Collectively, these data infer that modulation of tanycytic TSHRs plays an important role in BHB plasticity in relation with ingestive behavior. Presentation: Friday, June 16, 2023


Five different approaches have been used to obtain simple relations to study the temperature dependent volume and thermal expansivity of the solids. All the relations are found to be identical. The computation has been done on six geological solids and three metals with the help of these relations. All the relations are quite successful in representing the volume and the thermal expansivity as a function of temperature. However, the relation obtained with the help of Tait EOS (Equation of State) is found to be better.


In line with the characteristics of the Moskos (2000) paradigm of postmodern militaries, the South African National Defence Force (SANDF) was democratised during the early 1990s, which changed its civil-military relations from an autocratic top-down structure to a participatory system with civilian input. A civilian Defence Secretariat was instituted in 1995 and defence policies were democratised with the aim of obtaining civil control and parliamentary oversight of the military. The national concept of security was redefined, with the major focus on human security in conjunction with state security. Human security principles were found at all levels of defence and national policies (e.g. the South African Constitution, the Defence White Paper and the Defence Review). Consequently, new humanitarian missions, such as peacekeeping, were embarked upon in a no-threat South African scenario.
The aim of this paper is to focus on the new civil-military relationship in a postmodern South African military, based mainly on human security principles.


We study the heredity of local completeness and the strict Mackey
convergence property from the locally convex space E to the space of absolutely p -summable sequences on E , l p ( E ) for 1 ≤ p ∞ .


Which wish reached performed  of this research to analyse the influence motivate the job to labour capacity employees at PT. Makassar Raya Motor Makassar,  and also to analyse the relation of between motivation work with the labour capacity of employees at PT. Makassar  Raya Motor Makassar. To solve the the problems hence analysis method used by : analysis of regresi and correlation and also analyse the validity and reliabilitas for instrument research.
Result of analysis conducted  indicate that there are influence of between motivation to labour capacity of employees at PT. Makassar Raya Motor Makassar, this matter is knowable through/ passing analysis regresi of between motivation with the labour capacity employees, obtained by equation regresi that is Y = 0,957 + 0,730 ( X), indicating that with the existence of the make-up of job motivation of diiikuti with the make-up of labour capacity employees of equal to 0,730  and with the value prob < 0,05 can be said that by a motivation work to have an effect on by signifikan to make-up of labour capacity employees.


In this paper we present standalone SDL-based model for performance analysis and planning of IEEE 802.11a Wireless Local Area Networks (WLANs). The usage of WLAN has been extended from the indoor environment to the Internet access services in the outdoor environment. This implies particular needs for optimizing WLAN radio coverage. Also, one needs maximization of the throughput in the wireless channel. The fulfillment of these demands mostly depends on the placement of access points (APs), number of users, type of the environment and number of available channels. Therefore in this paper, using Specification and Description Language (SDL) model, we have created a powerful tool for analysis, planning and optimization of 802.11a wireless networks.


The four aspects of the textile air conditioning energy-saving measures are described including improvement of the traditional air-conditioning,reasonable regulation of air-conditioning system,cold heat source-saving,and other energy-saving measures,which can save 30%of total energy consumption and a lot of water,as an effective and feasible method for textile mills to reduce production costs, improve economic efficiency and market competitiveness.


This first book from SherAli Tareen is a masterful historical and theoretical analysis of South Asian Deobandi-Barelvi distinctions in the light of their respective responses to the challenges of modernity and colonialism. What is especially valuable is the author's close analysis of seminal texts of the eighteenth, nineteenth, and early twentieth centuries. While many existing studies emphasize social, institutional, and political histories of South Asian Islam, Tareen's readings of the original writings composed in Arabic, Persian, and Urdu offer refreshing and insightful observations that navigate the often complex and arcane logic and discursive fields of South Asian Muslim scholars while bringing these debates into conversation with contemporary Western critical theory, especially as relevant to religious studies and political theology, as well as drawing insights from contemporary scholarship on other religious traditions in confronting modernity whether Christianity or, in the South Asian sphere, Hinduism and Buddhism. An important source of Tareen's theorizing is the work of Talal Asad on secularism. The presentation is rendered particularly engaging through the author's literary flare and judicious incorporation of biographical anecdotes that illuminate individual personalities at pivotal junctures in history. The work consists of twelve chapters and provides an extensive critical apparatus, including suggestions for its use in a variety of


Abstract : To meet the need for reliable quantitation of trace levels of D2O in water, a differential infrared spectrophotometric procedure was developed. Two technics are discussed: one emphasizing a cell in - cell out approach without provision for temperature equilibration of the sample; and a second approach exploiting the advantages of rigid temperature control for reference and sample. The two technics are compared in terms of precision and accuracy, the latter method being decidedly superior. Both approaches are based on measurement of the O-D stretch at 2,510/cm. and enable assay of added D2O levels down to below 50 p.p.m. (w/w). The basic approach appears to be applicable to the direct quantitation of low concentrations of D2O in biologic fluids without sample preprocessing. (Author)


Microbial oil production is a feasible source of raw materials for biodiesel industry.Because of its excellent capability in grease synthesis and accumulation,Rhodotorula glutinis is a good candidate to produce microbial oil by molasses fermentation.The influencing factors,such as culture volume,pH value,inoculum concentration,temperature,nitrogen and carbon nutrition,were investigated by batch cultures.The results indicate that a dry-cell yield of 2.42g/L and a grease yield of 0.8g/L are obtained after fermenting for 132h with an initial COD concentration of 11100mg/L,pH value of 6.5,temperature of 30℃ and swing at 160r/min.The corresponding specific dry-cell and grease yield by COD removal are 0.35 and 0.12kg/kg,respectively.The dry-cell yield and grease yield could be increased to 3.74 and 1.31g/L,respectively,by adding 10g/L glucose instantly at a certain fermentation moment.The addition of nitrogenous nutriments to the fermentation system could promote the multiplication of R.glutinis remarkably,but has no observable influence on the grease yield.


We review recent work aimed at showing how global topological defects influence the shape of the angular power spectrum of the CMB radiation on small scales. While Sachs-Wolfe fluctuations give the dominant contribution on angular scales larger than about a few degrees, on intermediate scales the main r\^ole is played by coherent oscillations in the baryon radiation plasma before recombination. In standard cosmological models these oscillations lead to the `Doppler peaks' in the angular power spectrum. Inflation-based cold dark matter models predict the location of the first peak to be at \ell\sim 220/\sqrt{\Omega 0}, with a height which is a few times the level of anisotropies at large scales. Here we focus on perturbations induced by global textures. We find that the height of the first peak is reduced and is shifted to \ell\sim 350.


of the proposed equation can be determined using a soil property called "uniformity coecient" and the acoustic admittance of dry soil. Results of volumetric water content obtained using the proposed equation are validated using those obtained from an independent test. The results of the validation exercise demonstrate that the proposed relations can be used to determine very accurately the volumetric water content within soil from the acoustical data. The accuracy of the acoustically measured degree saturation is found to be within 2.0%.


Abstract The knowledge-based view of the firm portrays knowledge assets as the basis of sustainable competitive advantage. However, leveraging the knowledge available to the firm is not straightforward. The transfer of best practices within the firm or the replication of a certain routine poses challenges for managers. Causal ambiguity of knowledge makes it difficult to transfer practices into other contexts within the firm. In this paper, a new framework is proposed that identifies four antecedents to causal ambiguity: complexity, tacitness, relevance to the existing knowledge base, and the locality of knowledge. The paper concludes with the implications of the framework.


M. The sublethal effects of thiamethoxam, hexaflumuron, and acetamiprid insecticides on the growth period, reproduction, and life table of the two-spot ladybirds ( Adalia bipunctata Linnaeus, Col. Coccinellidae) feeding on common pistachio psylla. Pistachio and Health Journal. 2020; 3 (3): 33-44. Abstract Introduction: The common pistachio psylla, Agonoscena pistaciae Burckhardt & Lauterer (Hemiptera: Aphalaridae) is the key pest of pistachio trees in Iran. Controlling this pest is conducted by using chemical pesticides; this results in the destruction of the natural enemies of this pest and its outbreak. Adalia bipunctata Linnaeus (Col.: Coccinellidae) is one of the predators of pistachio psylla. Given the usage of three common pesticides i.e. thiamethoxam, hexaflumuron, and acetamiprid in pistachio


There is considerable dialogue in the clinical and health policy community concerning the implementation of value-based care, defined by the ratio of health outcomes to dollar spent and operationalized by payment models that link quality metrics to reimbursement, such as bundled payment for episodes of care or pay for performance, the focus of this issue's article by Hsieh et al. For those of us engaged in medical practice or its scientific study, these are familiar but concerning ideas, because this set of top-down theories does not always translate well to the real-world clinical environments and patient populations that they are purported to support. Indeed, the deceptively simple ratio that underpins value health involves a multidimensionality that makes measuring its true impact on cost-effectiveness far from transparent. Consider, for example, studies focused on the cost-effectiveness of pay for performance. Such studies are of increasing importance as the incentives are now linked to provider performance on quality benchmarks deployed by the Centers for Medicare and Medicaid Services (CMS) by requirements of the 2010 Patient Protection and Affordable Care Act (PPACA). Achievement of the quality metrics associated with processes of care and health outcomes drives reimbursement; therefore, critical operating margins for practices and systems are at risk. Because understanding the association between incentives and the cost and quality of care delivery is essential to current medical practice survival, it provides an opportunity to think through how we might creatively investigate this question to provide a realistic underpinning for policy implementation going forward. To date, pay-for-performance studies demonstrate inconsistency in their findings whether relating to the association between pay-for-performance and process and intermediate outcomes or to the linkage between incentive strategies and cost-effectiveness. This disagreement in evidence has been attributed to varying levels of methodological rigor. Despite the lack of a firm understanding of impact, health systems are now engaged in the rollout of payment strategies proposed to support value-based care in the absence of definitive research, indicating that providers can both maximize the utilization of health resources as well as improve the quality of health outcomes. Hsieh and colleagues examine these questions by pay-for-performance reimbursement strategies implemented in Taiwan's National Health Insurance Program. In their article, the authors describe the care context of the policy implementation and its evolution as it relates to process measures, and then present evidence on the intermediate and long-term health outcomes. Of particular note, pay-for-performance is analyzed in terms of its effects on quality-adjusted life years, a linkage few US-based studies have included. The authors provide a 2-stage analysis of the evolution of Taiwan's incentive program: a 2001 diabetes pay-for-performance design that used outpatient process of care measures (phase 1) and a 2006 change in the program that linked intermediate health outcomes to the incentive metrics (phase 2). They assess direct, long-term cost-effec-


In current resilience assessment frameworks for power distribution systems, the failure events of overhead structures e.g. utility poles are assumed independent. Since adjacent poles have similarities in wind exposure, age, rate of decay, and structural properties, among others, it is likely that a level of correlation exists between their failure events. To explore potential effects, here correlations among failure events of poles are considered in the simulation process using dichotomized Gaussian method (DGM) that generates correlated failure and survival events. A real distribution network in southeast of U.S. is chosen for the case study. The network consists of three substations with 7051 poles. Following realizations of the physical state of the infrastructure, connectivity based analyses are performed to estimate the number of customers without power considering time-dependent restoration sequences. Results indicate that correlations among failure events of poles have a noticeable impact on the resilience of the power system; neglecting this characteristic results in an error in the estimation of resilience of distribution systems. This may lead to risk management solutions such as maintenance and replacement of utility poles that are not optimal for resilience enhancement purposes.


Sharks present strong intraspecific changes in feeding habits, which may vary according to size, geographic location and season. This study analyzed the stomach contents of 52 juvenile scalloped hammerhead sharks (25 females and 27 males) caught by artisanal vessels in the Gulf of Nicoya. Regarding the organisms found in the stomachs, 41.07 % were teleost fish, 30.36 % mollusks and 28.57 % crustaceans. Mollusks presented the highest Relative Importance Index (RII) (43.05 %), followed by teleost fish (41.37 %) and crustaceans (15.58 %). Squids (Loliginidae) were the items with the greatest RII (32.57 %). By means of the Pianka index, a relatively low overlap between sexes was identified, suggesting a spatial sexual segregation and, in consequence, an ecological niche separation between male and female hammerhead sharks.


The invention discloses an intersection unit switching state synchronous method in a network element. The method comprises the following steps: a main intersection unit conducts a switching protocol to obtain and update a switching state and time slot configuration data; the main intersection unit sends the switching state and the time slot configuration data to a secondary intersection unit; the secondary intersection unit conducts real-time detection for the switching state and the time slot configuration data sent by the main intersection unit, and then updates the switching state and the time slot configuration data into a board switching state and time slot configuration data. In the method of the invention, the main intersection unit sends the switching state and the time slot configuration data to the secondary intersection unit, and the secondary intersection unit updates the switching state and the time slot configuration into the board switching state and time slot configuration, thereby effectively ensuring that the switching states and the time slot configuration of all intersection units in the network element are consistent, improving the stability of system multiplex section and channel switching, and avoiding influences on services.


An instrument that combines the analytical power of Raman spectroscopy with the spatial resolution of the Atomic Force Microscope (AFM) is presented. This instrument is capable of resolving 50 nm scale spectral features or better by using surface enhanced Raman scattering at the AFM tip. The localized spectrochemical information allows the interpretation of the concurrently acquired friction or phase contrast AFM images. This instrument has a unique combination of features including side illumination of the tip–sample interface that permits opaque samples. As a result of precise focusing of a laser at the AFM tip–sample interface this instrument is also capable of laser beam profiling and studying optical trapping at the probe tip. Applications of this versatile instrument include chemical analysis of nanometer scale phenomena, chemical separation, and the potential for targeted single molecule spectroscopy.


This paper addresses set theoretic estimation used for online learning in an adaptive filtering context. The advantages of set theoretic estimation over the traditional point estimation are shown, among which we highlight the capability of reducing the computational burden leading to energy saving. The set-membership affine projection (SM-AP) algorithm is the main framework because it generalizes many of the set theoretic algorithms, besides having a popular point estimation counterpart for benchmarking, viz. the affine projection (AP) algorithm. In addition, we discuss the effects of the design of the involved sets in convergence speed and steady-state MSE. Each iteration of the SM-AP algorithm exploits the intersection of constraint sets and, although any point in this set is acceptable, some of its parts should be avoided during the update. Moreover, we propose a new configuration for the error constraints, which leads to low steady-state MSE, high convergence speed, and low probability of update.


From a variety of long simulations of all-atom butane using both stochastic and fully solved molecular dynamics, we have uncovered striking generic behavior that also occurs in one-dimensional systems. We find an apparently universal distribution of transition event durations, as well as a characteristic speed profile along the reaction coordinate. An approximate analytic distribution of event durations, derived from a one-dimensional model, correctly predicts the asymptotic behavior of the universal distribution for both short and long durations.


In order to obtain the dynamic response characteristics of bridge pile foundation in permafrost regions under the effect of train vibration loading,strong vibration tests were carried out at two bridge pile foundations across the Qingshuihe River in permafrost region.The attenuation function of vibration response and the vibration energy distribution of the bridge pile foundation were obtained by analyzing the response of acceleration and response of Fourier Spectrum from the test data.On these in-situ test data,the dynamic finite element analysis method of transient dynamic analysis was applied to dynamic response numerical calculation on a test pile,as a case.Thus,the change rules of stress response and displacement response of the bridge pile foundation under the locomotive load are obtained.


An ongoing study in Mexico is seeking to explore womens and mens knowledge about reproductive tract infections (RTIs) sexually transmitted diseases (STDs) and family planning (FP) methods as well as how they deal with RTIs and STDs and select FP methods. This report includes the study methodology and results of the first phase (based on ethnographic qualitative approaches) which pertain to women. Data were gathered from 30 women in the free list phase (in which various themes were explores to gather the terms used by members of the sample when referring to RTIs and STDs) and 30 in the pile sort phase (in which women were asked to group cards listing the illnesses mentioned in the free list phase by similarities). All 60 women lived in Cuernavaca were aged 15-45 and had at least one child. The women answered the following questions: what are the illnesses that affect women between the waist and the pelvis what are the symptoms of these illnesses what are the causes of these illnesses what do women do to treat these illnesses what FP methods are used by women what characteristics should a FP method have to be chosen by a woman and what are the characteristics of a FP method rejected by a woman. Illnesses were sorted into two clusters: one which affects mainly men but can be avoided and one which affects mainly women and cannot be prevented. Symptoms were sorted into clusters of those considered controllable and those seen as more serious. Causes were sorted into four categories: 1) related to any illnesses; 2) caused by actions like using birth control beyond individual control and can result in miscarriage; 3) avoidable and controllable; and 4) associated with ignorance or embarrassment. Treatment groups were considered 1) most effective 2) common home remedies 3) actions taken before seeking home remedies or other treatment and 4) not effective. FP methods were distinguished by 1) familiarity safety and not requiring additional worry by the woman; 2) less secure but controllable by the woman; and 3) the most natural but not very effective. FP method categories were 1) not being associated with negative effects 2) effective and safe and 3) use related. Seven FP method rejection categories were related to discomfort expense bodily rejection affects on pregnancy causing illness ease in use and causing unwanted side effects.


Philosophical  or logical category of number is based on the existence of quantitative characteristics of things and events of  the reality. A human being first comprehended the number of things and objects and then tried to express them by means of  languages. Gradually there appeared the existence of more than one things and there emerged the necessity of expressing them. In Turkic languages, including Azerbaijani, the abundance of things began to be expressed by the numeral three , then it reached forty , which was the maximal limit. It found its expression in fairy-tales and eposes, as well as in proverbs. For instance: Atalar ucəcən deyiblər ( Our forefathers counted up to theree or allowed do something only thrice ); Uc gun, uc gecə yol getdilər ( They walked three days and nights );  Qirx gun mohlət vermək( They granted him a delay for forty days ); Qirx gun, qirx gecə doyusmək ( They fought for forty days and nights );  qirx qapini acmaq ( to open forty doors ); divin canini qirxinci otaqda tapmaq ( to find the vigour (life) of the giant in the fortieth room ), etc. All this shows that the expression of the category of number in language  has undergone a long historical process.


G98A,a new rice sterile line,was bred from Zhenshan 97A(a CMS line)×95F076 [a maintainer line bred from Nanjing 11(a convetional indica variety)×Nayongdahonggu(a local japonica variety)×8902S(a nuclear sterile line)]after eight genenations continuously.


Objective To analysis the efficacy of mouse nerve growth factor(mNGF) in acute spinal cord injury.Methods 75 cases patients with spinal cord injury were randomly diveded into treatment group(39cases) and control group(36cases).All patients adopted operative reduction and hormone dehydration.Treatment group added with mNGF.Compared the clinical efficacy of 2 groups.The efficacy was assessed by Functional Independence Measure(FIM) and Barthel Index.Results The total efficiency of treatment group(71.79%) was higher than that of control group(47.22%),the difference was statistically significant(P 0.05).The level of FIM and Barthel of 2 group before treatment was no statistically significant(P 0.05).The level of FIM and Barthel of 2 group after treatment were higher than that before treatment,the level of FIM and Barthel of treatment group after treatment were higher than that of control group after treatment,the difference was statistically significant(P 0.01 or P 0.05).Conclusion mNGF can effectively reduced the nerve injury in patients with acute spinal cord injury,and promote the recovery of neurological function.


As digital libraries grow rapidly in recent years, the security of digital library becomes the key issue concerned by administrators of digital libraries. Effective evaluation of digital library security is of great significance for the library administrator. This paper proposes a fuzzy integrated Security evaluation method which is based on man-computer combined data collection and fuzzy expert evaluation in Delphi method. The method could reduce the subjectivity of expert evaluation and alleviate the difficulty of data collection and makes possible a better combination of qualitative and quantitative evaluations. Firstly, the evaluation factor and hierarchy structure of digital library security evaluation is constructed. Secondly, data is colleted and according to the evaluation comment of each expert, the subjection degree matrix is constructed. Finally, a new concept of "degree of assurance" is presented for the quantificational evaluation of security. In this paper a case is presented to illustrate the method.


A project is located in the core area of the high-speed railway station, subject to large traffic volume and various controlling factors. A new steel-UHPC composite slab girder bridge is adopted based on and taking into account the characteristics of the project. Compared with the conventional structure, the self-weight of the bridge superstructure is greatly reduced; meanwhile, the size and weight of the lower part of the bridge are further reduced due to the fact that the prestressed concrete bent cap with large volume and weight is replaced by steel box beam; the fact that longitudinal and transverse beams are connected by high-strength bolts speeds up the on-site construction progress. Furthermore, components of the project have light self-weight and are easy to transport and install, which further reduces the impact of the construction on the environment. This paper introduces the design scheme and stress analysis of the new steel-UHPC composite beam structure, with the aim of providing reference for similar projects in the future.


In a competitive global market, organizations are striving to retain the best talent by providing sustainable employer value proposition EVP; 'value proposition' employees perceive or expect from their employer. Although EVP is conceptually appealing, there has been little systematic effort to empirically examine the dimensions of EVP. Information technology companies are adopting strategies to provide proposition that attract and retain employees. This paper identifies the attributes of EVP from the perspective of employees working in Information Technology companies in India. A scale is developed and validated to measure EVP on a sample size of 474. EVP scale was tested for its factor structure, reliability and validity. The results indicated that EVP scale comprised of five attributes; developmental value, inspirational value, work environment value, work value, and work life balance. The finding of the research is discussed; limitations noted; recommendations for enhancing EVP in IT companies, and future research directions.


Despite all the hoopla surrounding Apollo 11's moon landing, as well as the historical significance of the event, Matthew D. Tribbe argues that the excitement and meaning of the event quickly dissipated and even began to be questioned by the early 1970s. In essence, Tribbe has constructed an alternative assessment of the meaning of the Apollo space program and the manned moon missions. Using movies, music, and literature from the late 1960s and 1970s, Tribbe strives to "unlock some of the symbolism of Apollo to explore what it meant to a confused nation entering the 1970s" (15). He accomplishes his objective well by presenting an intriguing and thought-provoking analysis from a unique cultural perspective on the Apollo space program. Central to Tribbe's argument is the idea that the United States is culturally shifting from a "postwar rationalist idea" to a "neo-romantic" foundation (21). In a narrative that parallels the history of the Enlightenment, Tribbe recounts how the emerging neo-romantic culture of the United States began to question the faith in science and technology that had come to represent the foundation of the United States during the Cold War, especially under the tenure of Presidents Eisenhower and Kennedy. In its place, concerns about "dangerous science and the technocratic path" of the United States emerged, as a specific segment of the American populace questioned the utility and application of these signs of progress (16–19, 226–27). Highlighting this internal cultural struggle is an important part of Tribbe's research. However, his follow-through falls short and only provides a single view of Apollo. By only focusing on Apollo and neo-romantic culture in the United States of the late 1960s and early 1970s, Tribbe loses the Cold War and longer historical context of the space age. Tribbe fails to recognize that the space age and the subsequent space race are elements that embedded themselves in the Cold War culture of the United States in the immediate post–World War II period. Arguing that the US population lost interest in the space program after Apollo is a fine point to make, but it is shortsighted and underdeveloped. Tribbe fails to acknowledge the significance of the Mercury and Gemini manned space programs, not to mention the various other NASA and military satellite projects that permeated the Eisenhower, Kennedy, and Johnson administrations, which generated significant public interest. This lack of understanding of the history of the Cold War and space age is problematic, as it prompts Tribbe to analyze the tail end of the second phase of the space age, as well as the era of d etente, without any contextual understanding of what happened previously and how the past influenced the period he is researching. His analysis, which is permeated by references to popular music, television shows, and science fiction movies, becomes myopic and leaves the reader wondering about other elements of society that were not neoromantic and still adhered to the rational and technocratic tenets defined earlier in the Cold War era. Looking beyond the neo-romantic interpretation of the Apollo space program causes Tribbe's conclusion to lose some of it vigor and opens his thesis to criticism. In the end, Tribbe has written an insightful history of a cultural change that took place in the United States as the Apollo space program came to close, but one also needs to consider the impact of d etente, civil rights, and the VietnamWar as additional forces that shaped and challenged the prevailing cultural tenets of the United States. Recognizing the limitations of his work, Tribbe's No Requiem for Apollo is still a worthy addition to the library of anyone interested in understanding the dynamic history of the United States in the late 1960s and early 1970s.


Taking the Differential Mode of Association( DMA) of the interpersonal relationship in China as the point of penetration,this paper analyses the new characteristics of the leader subordinate relationship under the DMA.Based on this,the author constructs the Circle Layer Model of the leader subordinate relationship,and analyses the effects on the leader subordinate relationship under the DMA to the employees' performance.The research assumes that the mode of action of the effects on the leader subordinate relationship with the DMA to the employees' performance under the regulating effect of different matrices atmosphere,is completely different from the western organizational situation.It means that they have a positive relationship only when they are in the low DMA atmosphere; and the interactive effect among the trust,the employees' fairness perception,and the leader subordinate relationship have a positive effect on the employees' performance.


In order to break the traditional monitoring method of substation and promote the intelligent process of substation, this paper took BZ substation as the research object, studied the key technologies of its integrated monitoring management system and tested the performance of the integrated monitoring management system. It was found that the average throughput of the system was 1649583KB/s, and the average response time was 0. 25ms. The maximum response time is 1. 735s, and the results can meet the actual requirements, which confirms the performance of the integrated self-monitoring management system and can improve the intelligent process of the substation.


Ethical counselling is a process which facilitates the identification of ethical dilemmas that individuals or organizations are facing and ways out of these dilemmas that are most congruent with the vision shared by the individual or organization, context in which supervision of individuals intervenes as a support process. The paper starts from a set of convergence that we could find between philosophical practice and the counselling process specific to the field of social welfare. We see those convergences through a methodological aspect, but also from axiological, teleological and pragmatic points of view. We will present in what follows a practice model of counselling of ethics derived from counselling in social welfare. We mention that philosophical ethical counselling model that focuses on solving ethical dilemmas represents a transposition of social practice at the level of counselling of ethics.


In 2003, Japanese government instituted and implemented "Nation-building upon Tourism Strategy".From the strategic connotation,strategic task, strategic objectives and the policy measures which taken by the Japanese government in recent years, one will come to see that "Nation-building upon Tourism Strategy"is not only play very important role in Japan's development of international tourism,increasing the domestic employment and promoting the development of local economy, but also in building the good national image,enhancing Japan's national confidence and happiness,etc, which has played an irreplaceable role in promoting cultural soft power.the experience that Japanese improving national cultural soft power through developing tourism,may provide a reference for our government to make national tourism development strategy.