In this study, enantioseparations of five phenothiazines, including promethazine, ethopropazine, trimeprazine, methotrimeprazine, and thioridazine, in CD‐modified CZE using dual CD systems consisting of randomly sulfate‐substituted CD (MI‐S‐β‐CD) and a neutral CD as chiral selectors in a citrate buffer (100 mM) at pH 3.0 were investigated. The results indicate that MI‐S‐β‐CD is an excellent chiral selector for enantioseparation of ethopropazine. The enantiomers of promethazine can also be baseline‐resolved with MI‐S‐β‐CD at concentrations in the range of 0.5–1.0% w/v. On the other hand, thioridazine and trimeprazine interact strongly with neutral CDs. As a result, the enantioselectivity of these two phenothiazines is remarkably and synergistically enhanced with increasing the concentration of neutral CDs in the presence of MI‐S‐β‐CD and simultaneous enantioseparations of these phenothiazines, except for methotrimeprazine, could favorably be achieved with the use of dual CD systems. Moreover, by varying the concentration of β‐CD or γ‐CD at a fixed concentration of MI‐S‐β‐CD (0.75% w/v) reversal of the enantiomer migration order of promethazine occurred. This may be attributable to the opposite effects of charged and neutral CDs on the mobility of the enantiomers of promethazine.


Objective To summarize clinical experience of skin defects reparation with modified rhomboid flap.Methods 46 patents with skin and soft-tissue defects were admitted to our department since 2006,the focus area ranged from 1.2 cm×0.6 cm to 7.0cm×4.5cm.The modified rhomboid flap was formed beside defect and elevated from superficial fascia layer,transferred into defect without tension.Results All flaps survived with primary healing postoperation except partial necrosis in 2 cases,the aesthetic and functional results were satisfactory with the mild scar after 1 months to 5 years following-up.Conclusion The elevating of modified rhomboid flap is easy and simple.It is a good method for repair of skin defects.


Exhibitions have played a key role of effective marketing activity which directly informs services and products to current and potential customers. Through participating in exhibitions, exhibitors have got the opportunity to make face-to-face contact so that they can secure the market share and improve their corporate images. According to this economic importance of exhibitions, show organizers try to adopt a new IT technology for improving their performance, and researchers have also studied services which can improve the satisfaction of visitors through analyzing visit patterns of visitors. Especially, as smart technologies make them monitor activities of visitors in real-time, they have considered booth recommender systems which infer preference of visitors and recommender proper service to them like on-line environment. However, while there are many studies which can improve their performance in the side of new technological development, they have not considered the choice factor of visitors for booth recommender systems. That is, studies for factors which can influence the development direction and effective diffusion of these systems are insufficient. Most of prior studies for the acceptance of new technologies and the continuous intention of use have adopted Technology Acceptance Model (TAM) and Extended Technology Acceptance Model (ETAM). Booth recommender systems may not be new technology because they are similar with commercial recommender systems such as book recommender systems, in the smart exhibition environment, they can be considered new technology. However, for considering the smart exhibition environment beyond TAM, measurements for the intention of reuse should focus on how booth recommender systems can provide correct information to visitors. In this study, through literature reviews, we draw factors which can influence the satisfaction and reuse intention of visitors for booth recommender systems, and design a model to forecast adaptation of visitors for booth recommendation in the exhibition environment. For these purposes, we conduct a survey for visitors who attended DMC Culture Open in November 2011 and experienced booth recommender systems using own smart phone, and examine hypothesis by regression analysis. As a result, factors which can influence the satisfaction of visitors for booth recommender systems are the effectiveness, perceived ease of use, argument quality, serendipity, and so on. Moreover, the satisfaction for booth recommender systems has a positive relationship with the development of reuse intention. For these results, we have some insights for booth recommender systems in the smart exhibition environment. First, this study gives shape to important factors which are considered when they establish strategies which induce visitors to consistently use booth recommender systems. Recently, although show organizers try to improve their performances using new IT technologies, their visitors have not felt the satisfaction from these efforts. At this point, this study can help them to provide services which can improve the satisfaction of visitors and make them last relationship with visitors. On the other hands, this study suggests that they managers along the using time of booth recommender systems. For example, in the early stage of the adoption, they should focus on the argument quality, perceived ease of use, and serendipity, so that improve the acceptance of booth recommender systems. After these stages, they should bridge the differences between expectation and perception for booth recommender systems, and lead continuous uses of visitors. However, this study has some limitations. We only use four factors which can influence the satisfaction of visitors. Therefore, we should development our model to consider important additional factors. And the exhibition in our experiments has small number of booths so that visitors may not need to booth recommender systems. In the future study, we will conduct experiments in the exhibition environment which has a larger scale.


ADAMS, CYRUS C. Maps and map-making. Harper 124:237-43. (Ja. '12.) ADDAMS, JANE. A new conscience and an ancient evil. McClure 38:471-78. (Fe. 'I2.) AITON, GEORGE B. The small high school of the middle west: a Minnesota type. School R. 20:90-97. (Fe. '12.) (An) American education for an English peer. Lit. D. 44:205. (3 Fe. '12.) Arguments advanced for a recreation commission. Playground 5:351-53. (Ja. '12.) BARDEEN, C. W. The monopolizing woman teacher. Educa. R. 43:17-40. (Ja. '12.) BEYER, HENRY G. The international hygiene exhibition at Dresden. Pop. Sci. Mo. 80:105-28. (Fe. '12.) BOYNTON, PERCY H. Suggestions for the English-literature section of a highschool library. School R. 20:111-16. (Fe. '12.) (The) "boy's own books" of today. Lit. D. 44:211-12. (3 Fe. '12.) BRICKER, GARLAND A. Problems in the experimental pedagogy of elementary agriculture. J. of Educa. Psychol. 3:29-34. (Ja. '12.) CAMERON, NORMAN. A new method for determining rate of progress in a small school system. Psychol. Clinic 5:251-64. (Ja. '12.) CHUBB, PERCIVAL. The menace of pedantry in the teaching of English. School R. 20:34-45. (Ja. '12.) COOPER, CLAYTON SEDGWICK. The American undergraduate. Cent. 83: 514-23. (Fe. '12.) (The) cultural and the vocational in the college curriculum. Educa. 32:284309. (Ja. '12.) ALLINSON, Culture, the ideal of the college. 284-92. BIRDSEYE, The college curriculum as a preparation for vocation. 293-309. A bbreviations.-Atlan., Atlantic Monthly; Cent., Century Magazine; Cur. Lit., Current Literature; Educa., Education; Educa. R., Educational Review; El. School T., Elementary School Teacher; Harp. W., Harper's Weekly; J. of Educa. Psychol., Journal of Educational Psychology; Lit. D., Literary Digest; Pop. Sci. Mo., Popular Science Monthly; Psychol. Clinic, Psychological Clinic; R. of Rs., Review of Reviews; School R., School Review; Sci. Am. Sup., Scientific American Supplement; Scrib. M., Scribner's Magazine; Teach. Coll. Rec., Teacher's College Record.


This article discusses the short history of a group of university students gathered around a Warsaw periodical Akademik, published from 1945 to 1947 as a mouthpiece of Towarzystwo Bratnich Pomocy. The article analyses periodical's content and provides a general picture of this group. Akademik's editorial team and its fellows and publicists were members of different youth organisations (including political ones), such as Academic Association of Young Fighters (AZWM "Zycie"), ZNOS, OKSMW "Wici", Democratic Youth Association (ZMD), Bratnie Pomoce, Academic Section of Former Political Prisoners (Sekcja Akademicka Bylych Wiezniow Politycznych) and Academic Sports Association (AZS). Akademik commented on various topics, such as life at the academia and students' accommodation, but it also featured polemic articles on ideology and politics. Around a year before the last issue was published a group of students left the editorial team and began to work with Stronnictwo Pracy.


This paper discusses the path to achieve carbon neutrality in the construction field, which is divided into five parts: (1) China's carbon peaking and carbon neutrality goals and consensus on the development of the construction industry; (2) The sustainable green building development trend and relevant policies in China; (3) The green building evaluation system and common software in China; (4) Building carbon emission evaluation model and the decarbonizing tools for the whole life cycle of construction projects; (5) Carbon emission reduction technology evaluation framework of autoclaved aerated concrete production in China. Through the discussion of this paper, we will jointly provide intellectual and technical support for the exploration and implementation of building carbon neutralization path.


Based on the statistic data during 1996~2012,this research measured the contribution rate of such factors,like human capital,material capital and technology promotion,to the economic increase in Chinese culture industry.And the short-term and the long-term equilibria,between these three factors and culture industry,has also been measured.The results indicate that Chinese culture industry is still in the pattern of an extensive economic growth,and mostly increased due to the material capital and labor input,while the role of human capital and technology promotion is not obvious.Meanwhile,the long-term equilibrium result shows that human capital will be more important than material capital in the long run.On this basis,some suggestions for the development of Chinese culture industry in the future were proposed in this paper.


Abstract. 47 patients with chronic renal failure were investigated for plasma 25‐hydroxycholecalciferol (25‐OH D3) concentration, serum calcium, phosphorus, alkaline phosphatase. 22 patients had chronic haemodialysis twice weekly. There is a highly significant positive coefficient of correlation between calcaemia and 25‐OH D3 plasma concentration. Levels of serum calcium had previously been shown to correlate well with the presence and type of osteodystrophies in chronic renal failure. Since these patients may be unable to synthesize 1,25 dihydroxy D3, the metabolite of vitamin D3 considered to be active on intestine and bone, a direct role of 25‐OH D3 in the regulation of calcium metabolism may have to be considered.


The invention discloses a wireless intelligent monitoring system for a residential district, and the system comprises an EIB bus, a power module, a service interface panel input module, a sensor input module, a switching control module, a security system, a monitoring signal system, a building control system, a remote control system, a communication module, an extension I/O module, an upper computer, and a wireless terminal. An EIB power supply is used for supplying for a bus and all function modules and systems in parallel connection with the bus. The data transmission between the upper computer and the communication module is achieved through the Ethernet. The wireless terminal is connected with the communication module through a wireless network, and the wireless terminal can be a cellphone, a computer, and other portable communication equipment. The above function system modules are parallel modules, work independently, do not affect other system modules and can be increased and disassembled, thereby achieving flexible and diversified effects.


A fiber-optic pin diagnostic technique is developed for measuring shock arrival time by taking the shock-induced luminescence characteristic of fused quartz.When the detonation wave front reach the tip of the fiber pin,a intense optic pulse is produced.The visible pulse is transmitted via fiber to a photomultiplier optic-to-electrical converter then to oscillograph for recording.The shock arrival times can be gotten by read the signals that recorded in oscillograph.Arrays of 0.3mm quartz fiber-optic pins are used to diagnose detonation wave front of one-point detonated GI-920 explosive(blast pressure of which is 10GPa).The shock wave front in three different diameters are gotten successfully in the experiment.The three dimensional shock wave front is reconstructed by using the data obtained.The results indicate that the dispersivity of the shock arriving times and the obliquity of the shock wave front are obviously increased with increasing the radius of test.The rise time of signals obtained in experiment are less than 4ns,indicating that the fiber-optic pin is a high time resolution method of measuring the shock time parameter of explosive.


The germination percentage of seed and seedling growth in liquid nutrient culture were examined. The relative salt tolerance of sugarbeet was evaluated by germination percentage of seed and dry matter of seedling, the suitable concentration of NaCl stress was 280mmol/L, under the concentration, the germination percentage of seed and relative growth of seedling in different sugarbeet lines were more different, the positive correlation between relative germination percentage of seed and relative growth of seedling had a significant difference. The seed needed the same breeding year when the salt tolerance of sugarbeet was valued by the germination percentage of seed, it is accurate and reliable to evaluated the salt tolerance of sugarbeet by the relative growth of seedling in liquid nutrient culture. More than ten lines of each type of which strong, medium and sensitive salt tolerance was screened by above methods.


The paper describes a real-time system which tracks the uncovered/unmarked hands of a person performing sign language. It extracts the face and hand regions using their skin colors, computes blobs and then tracks the location of each hand using a Kalman filter. The system has been tested for hand tracking using actual sign-language motion by native signers. The experimental results indicate that the system is capable of tracking hands even while they are overlapping the face.


Nearly two years ago the ATO held a symposium with large corporates. It was ambitious and aspirational in intent, but not unrealistic. It was one of a number of steps taken to build a more open and productive relationship with the large business community. It was an invitation to move to more collaborative approaches. If there is one message from today, it is to reiterate that invitation.


The investigation of ornithological biodivesity of Moscow meets with a constant problem of correction of species' lists. In connection with the recent extension of city territory and appearance of ledges beyond the bounds of Moscow encircling highway the former lists become fast outdated. Publishing a cycle of articles on biodivisity of Moscow birds, we open it with updated species' list.


This paper reconsiders the Lipsey-Lancaster [4] theory of second best and formulates less restrictive sufficient conditions for the preservation of the usual first-order conditions for the non-deviant commodities. In particular, we derive a more general class of separable objective and constraint functions which yield the result that, even in the presence of a Lipsey-Lancaster constraint for deviant commodities, the usual Paretian optimum conditions for the non-deviants continue to be optimal. Consider the maximization problem: max F(x1, ..., xn)


Pericarditis and pericardial effusion (PE) are rare but potentially life-threatening complications in chronic graft-vs-host disease (cGVHD). Limited data are currently available in this setting, based on small single-center retrospective studies. The purpose of this study is to characterize the clinical presentation, management, and outcomes of pericarditis and PE complicating cGVHD in allogeneic hematopoietic cell transplant recipients.

 We included all consecutive patients referred to our pericardial diseases referral center from 1st May 2008 to 1st May 2022. All patients had no previous cardiovascular or autoimmune diseases and suffered from severe cGVHD with involvement of at least 2 organs. Pericarditis and PE were diagnosed according to ESC guidelines. Conditioning-related toxicity and infections were carefully excluded.

 Pericarditis was diagnosed in 4 patients (2 males, mean age 48.5 ±9.0 years), of whom 2 developed mild PE. PE without pericarditis was diagnosed in 5 patients (80% male, aged 53.2 ±8.9 years), in 2 patients it was reported as severe, requiring pericardial drainage. The average time after allogeneic hematopoietic stem cell transplantation was 22 months (range, 4 to 58 months). All patients required escalation of the corticosteroid therapy they were chronically taking, and in 4 cases the therapy was boosted with non-steroidal anti-inflammatory drugs. Only one patient developed a recurrence and died of multiorgan failure associated with severe cGVHD (involving eyes, mucous membranes, skin, joints, liver, pleuro-pericardial effusion) refractory to immunosuppressive therapy. Overall survival was 89% and no patient developed constrictive pericarditis. Mean follow-up was 69±55 months.

 Pericarditis and PE related to cGVHD typically occur with mild clinical signs in the context of severe cGVHD, however in our study 22% of patients required pericardial drainage at diagnosis. The mainstay of treatment is high-dose steroids and usually the majority of patients have a favorable outcome.


. The cost of feeding represents the largest item in the production of animals of zootechnical interest, in this sense, recent research has focused on the use of alternative foods that can compete with conventional raw materials in quantity, quality and price. The objective of this work was to analyze scientific information on the current situation of the use of hydroponic green forage for feeding animals of zootechnical interest on a small and medium scale. The present investigation was exploratory and was based on an updated bibliographic compilation. The introduction of hydroponic green forage of sorghum, corn, wheat and barley in the diet of pigs, poultry, rabbits, guinea pigs, allows to reduce the cost of feeding, it is easy to produce, it is grown all year round, it requires little space, it presents high nutrient utilization coefficients. In addition, it allows to achieve a significant increase in the increase of weight, consumption, weight gain and feed conversion of the animals. The production of hydroponic green forage is an easy technique to apply and does not require a high initial investment for its implementation in the feeding systems for animals in small and medium scale farms.


SUMMARY This paper proposes a high throughput small latent IP packet delivery architecture using ATM technology in a large scaled internet. Data-link network segments, including ATM network segments, are interconnected through routers. A connection oriented IP packet delivery will be provided by IP (including both IPv4 and IPv6) with a certain resource reservation protocol (e.g. RSVP). When the router attached to ATM network segment has a mapping function between the ow-ID (e.g.in the SIPP header) and the VPI/VCI value, the small latent connection oriented IP forwarding can be provided. Also, when the router has cell-relaying functionality, the small latent connectionless IP forwarding can be provided, even in IPv4. The source router, where the source end-station belongs to, will be able to transfer the connectionless IP packet to the destination router, where the destination end-station belongs to, through the concatenated ATM connections (ATM-VCCs) without any ATM-VCC termination point. When all of the network segments are ATM-LAN, the proposed architecture can accommodate about up to 2 22 (' 410 6) end-stations with two network layer processing points. And when the network is scaled up hier-archally, we can accommodate larger number of end-stations. For example, we can accommodate 10 15 end-stations by a three lay-ered network. Then the maximum number of actual network layer processing points between source and destination end-stations can be ten. Here, 10 15 is the maximum number of end-stations in ISDN and also it is the target number of accommodated end-stations for IPv6.


Multi-stage cylindrical gearboxes are used in the entire drive train technology. In addition to a sufficient load capacity and high gearbox efficiency, the acoustic behavior has to be taken into account. The increasing demands on the acoustic behavior appear in customer requirements and amended law restrictions, e.g., in automotive or wind industry (Refs. 21; 19). For a single-stage gearbox, several research projects have been carried out (Refs. 3–4; 13; 15–16). Because of the mutual interactions between the gear meshes at a two-stage gearbox, the knowledge cannot be transferred directly without restrictions. The excitation behavior of gearboxes is mainly determined by the gear mesh excitation. A selection of influence factors is shown in Figure 1. In order to reduce the parametric excitation, an integer contact ratio is recommended by changing, for example, the helix angle or the face width (Ref. 23). On the one hand, flank modifications influence the pathdependent excitation. On the other hand, they are often used to reduce the impact excitation. The consideration of parametric, path-dependent and impact excitation in the acoustic-oriented design of single-stage gearboxes is state of the art, especially for quasi-static and partly for dynamic conditions (Refs. 11; 16–17). For multi-stage gearboxes, additional parameters have to be taken into account. Firstly, the gears of the first stage enter mesh related to the line of action. Due to the gear geometry, the time when the gears of the second stage enter mesh is mostly temporally displaced. This phenomenon is called phase shift. Furthermore, the stiffness of the connecting shaft between the gear meshes influences the interaction of the single gear stages. Due to a differing number of teeth in the two stages, the noise behavior of the entire gearboxes changes, as well. In this report, the influence of the phase shift between the gear meshes is investigated by means of calculations. Hence, discrete values of the phase shift are inserted and investigated. The calculation procedure was validated based on tests with a single-stage gearbox and enhanced to a two-stage gearbox.


Measurements of the rate of decay of the first triplet state of the Ne/sub 2/ molecule in Ne/O/sub 2/ mixtures have been performed by fast spectrophotometric monitoring of this species at 814 nm. The rate constant for electronic quenching of vibrationally relaxed Ne/sub 2/ (/sup 3/..sigma../sub u//sup +/) by O/sub 2/ has been found to be equal to 3.67 ( +- 0.14)10/sup -10/ cm/sup 3/ molecule/sup -1/ s/sup -1/ at 298 K. A new upper limit to the value of the spontaneous radiative decay constant is equal to 1.28( +- 0.02) 10/sup 5/ s/sup -1/. Dependence of the excimer yield on O/sub 2/ concentraion appears to indicate that electronic three-body quenching of the atomic precursor(s) predominates markedly over vibrational relaxation of Ne/sub 2/(/sup 3/..sigma../sub u//sup +/, v). The excimer yield is, accordingly, extremely sensitive to the presence of impurities at high neon pressures.


Sir, As specified in your letter, there has been an increase in awareness and recognition of the Takotsubo cardiomyopathy by some specialists such as cardiologists. However, this disease remains unknown by forensic specialists while victims are often faced with violent and stressful circumstances such as an assault or an accident. Fatal outcomes involving cardiac arrhythmias, free wall rupture of the left ventricle, and thromboembolism occur during the acute phase of the disease. Moreover, recent studies were conducted on predictors of outcome, and some suggested that this short-term prognosis is not as favorable as generally considered (1, 2). Despite these observations, Takotsubo cardiomyopathy is a reversible cardiomyopathy. The long-term prognosis is still considered favorable, and mortality is estimated to 1.1% (3). This data could contribute to the unawareness of Takotsubo cardiomyopathy by the forensic specialists, who mostly investigate dead people. In France, the public prosecutor orders a medico-legal assessment after an assault for all living victims to describe the injuries, establish a causal relation between the assault and the injury sustained, and determine the duration of disablement. The diagnostic of Takotsubo cardiomyopathy described in a clinical forensic unit is an illustration of the possible collaboration of forensic specialists with other specialists such as radiologists or cardiologists for the medico-legal assessment of the living victims.


One problem in CIMS is the complex security administration of data resource. The traditional access control is dispersed among the network OS, DBMS and application systems without uniform access control strategy. The Integrated Role Based Access Control (I-RBAC) Model for CIMS is presented based on the current RBAC model. The content and the rule of the model are studied through static and dynamic way. The structure of model is provided and the security of the role is analyzed. The model is applied to the CIMS of one tobacco group and makes the access control be seasoned with the special secure strategy of enterprise.


The dissertation mainly addresses different issues regarding the impact of regulation in a competitive market and how market participants react strategically in such market. It consists of four chapters that address the impact of certain regulation and how would market competition play a role in such dynamic. The scope of these chapters is not restricted to accounting regulations but accounting regulations or markets for accounting professionals are mainly embedded in the settings which my dissertation investigate. In general, this disertation extends the understanding on the impact of regulation or accounting related regulation on market particpants and market as a whole, for instance their market output, comeptitive strategic disclousre and market structure changes.


We present the status of prototype work on the main components of the LNLS 500 MeV booster synchrotron project. We present results of the characterization of the booster magnets and power supplies.


CFD numerical simulation system is a combined technology of CFD flow solving, grid generation, data visualization and networking. This paper described an integrated interactive CFD simulation system for subsonic, transonic and supersonic flows, running in a network environment. This system can easily integrate various flow solvers for complex configurations, including panel method codes, potential flow codes, and codes for Euler and Navier Stokes equation through its unified data interface. This paper also described the development of the system architecture, the software structure, the pre processor for geometry and grid generation, the powerful flow field solvers, and the advanced data visualization subsystem.


Anti-alloantibody whole molecules and subunits have been shown to inhibit specific recognition of foreign antigenic determinants by certain thymus-dependent lymphoid cells. The present investigation was designed to demonstrate whether anti-Fab and anti-Fc alloantibodies raised against Fab and Fc fragments prepared by papain digestion of tumor-enhancing IgG2 could prolong the survival of C3Hf/He (H-2k) fibrosarcoma allografts in TS (H-2s) mice. Prolonged survival of tumor allografts was observed in TS mice that received anti-Fab alloantibody followed one hour later by tumor allotransplantation, whereas anti-Fc alloantibody showed no such effect when assayed under similar conditions. By contrast, no significant difference in allograft survival time was observed between TS mice that received anti-Fc alloantibody and control mice that received 0.15 M NaCl each followed within one hour by tumor allotransplantation. The injection of γ -globulin fraction of alloantisera absorbed with enhancing Fab fragments cova...


Introduction: allogenic hematopoietic stem cell transplantation (HSCT) is the only currently available curative treatment for a number of high-risk hematologic malignancies and for a range of inherited and acquired non-malignant diseases. Haploidentical (HI) HSCT is a valid option for patients who lack an HLA-identical brother. Objective: to describe the results obtained with HI HSCT in pediatrics. Method: in 2005 an HI HSCT program was started at the Pediatric Hemato-Oncological Department of the Centro Hospitalario Pereira Rossell, for patients who lack an HLA-matched related donor. Results: Thirty two patients were transplanted, 24 of them with hematological malignancies and 8 with non-malignant diseases. Two strategies were used to prevent the Graft-Versus-Host-Disease (GVHD), in- vitro T-cell depletion (28 patients) and in-vivo depletion of aloreactives T-cells with high-dose post-transplantation cyclophosphamide (4 patients). Successful engraftment occurred in 27 patients (84%), with full-donor chimerism. Incidence of acute and chronic GVHD was 26.9% and 11.8% respectively. One year non-relapsed mortality was 21.9%. With a median follow-up of 32 months, the overall survival was 52.4%. Conclusions: HI HSCT has proved to be a feasible option in our country for those patients without an HLA-identical donor. The results obtained are comparable to those obtained with other alternative donors and costs are more reasonable. Today, Uruguay is in a better position to offer a HSCT to patients who need it.


`Britishness' is a relatively newly coined term. When running a spell-check after drafting this paper, my word-processing programme did not know the word and wanted me to substitute ̀ Brutishness' instead. Though that would have produced interesting results, I continue to use the term Britishness in this paper, meaning by it a sense of being British, an identification with Britain. Not surprisingly, given the enormity of the topic, and the difficulties of giving it a precise definition, no one has to date attempted an overview of Britishness across the whole of South African history. Here I can do little more than suggest some themes that need to be explored in greater depth. When one considers Britishness in South Africa, or elsewhere, two major questions loom — these are the ones I wish to address here briefly. First: what forms did it take? In other words, what did it mean to different people? I will attempt to illustrate some of the immense variety of forms it took in the South African case for three main groups of people. One should break these groups down, and discuss sub-groups, but here I will mainly discuss Britishness in terms of, firstly, those I call the English, people of British ancestry or descent who settled in South Africa and spoke English as their first language. Secondly, I consider the Afrikaners, who, except in Natal, have always been a majority of whites. Descendants of the Dutch at the Cape before the British arrived at the end of the eighteenth century, they can in some ways be compared to the French Canadians, though the latter lost their majority position among whites as Canada united. Thirdly, I discuss black people of various kinds. The San huntergatherers and the Khoi pastoralists were the South African equivalent of the Aborigines of Australia or Canada's First Nations. It is the descendants of the mixed farmers, who arrived later and whom the Dutch and then the British encountered as they penetrated the interior of the subcontinent, who today are usually known as black Africans. Many people of mixed descent, today known as Coloureds, and of Indian origin were also oppressed under apartheid and also came to call themselves black. In South Africa, of course, unlike other British settler colonies, the indigen-


The current and the generation power of resonant tunneling diode versus frequency and applied dc bias voltage are determined from the numerical solution of the time-dependent Schrodinger equation. It is shown that the amplification takes place in the region which is substantially broader then the interval of the negative differential conductance, and the maximum available frequencies essentially exceed values obtained for this region. It is also shown that at various constant voltages on the heterostructure maximum efficiency will be obtained at different frequencies, and even a small deviation from the optimal frequency decreases its value sharply. Influence of impurities of various types on high-frequency characteristics of the structure is investigated. It is shown that impurities with negative potential influence on the efficiency of this device weakly, while the impurities with positive potential suppress this characteristic essentially.


The perceptual image hashing is an emerging technique which can be used in image authentication and content-based image retrieval. Design of an image hashing scheme which has both robustness and fragility properties is becoming a new challenge. Recently, Xiang et al. proposed a histogram-based image hashing scheme which achieves a good robustness to perceptually insignificant attacks. However, the fragility to malicious attack is not optimistic. In this paper, we propose an improved histogram-based image hashing scheme by using K-means algorithm, which obtains a better fragility result than original one. In particular, we firstly segment the image into two segments by using K-means algorithm, then extract histogram in each segment. Finally, we combine two bin groups and generate the image hash value. The experimental results confirm that our improvement not only preserves the robustness of original one, but also enhances the fragility to malicious attacks.


Taiwan and the world are entering a new century. In this new century, the new president of Taiwan has a mission for Taiwan and also has responsibility toward the world. Located at the juncture of Eastern and Western civilizations, Taiwan is a site for friction and instability because of the clash of civilizations. It also plays the role of a balancer among world powers. Taiwan's future president in the new century should ensure Taiwan's security, survival, and development. He should also lead Taiwan and develop the distinct dynamism, endurance, and creativity of this immigrant-dominant society so as to make specific contributions to the mankind of the next century in its pursuit of a more progressive and harmonious civilizing process.


The main parameters of a local oscillator distribution in the millimeter wave range are described. The link is based on optical frequency multiplication taking benefit of the modulator nonlinearity. It is modeled using an original computer aided design (CAD) approach. Then, various practical solutions are compared and their phase noise floor is measured. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:1313–1316, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26780


This article describes the development ofconstruction and real estate industry in recent years inWeihai City and some issues related to city's sustainabledevelopment are reported. Further more, the relationshipbetween them is analyzed, especially in a city planner'sview,and also some suggestions about sustainabledevelopment and environment protection in cityplanning working are given.


Ancient Arms Race. Antiquity's Largest Fortresses and Sasanian Military Networks of Northern Iran. (The British Institute of Persian Studies Archaeological Monographs Series VII, Volumes I and II). By Eberhard W Sauer, Jebrael Nokandeh & Hamid Omrani Rekavandi. 22 30 cm. 2 volumes: xviii þ 880 pp, 743 colour and b&w figs, 164 tables. Oxford & Philadelphia: Oxbow Books, 2022. ISBN 978-1-78925-462-4; epub: 978-1-78925-463-1. Price: £90.00 hb.


To evaluate wrinkle improvement and safety of a novel cosmetic dissolving microneedle patches loaded with two active compounds with different hydrophilicities, namely ascorbic acid and retinyl retinoate.


Born in New York City on August 11, 1928, he first developed a passion for world peace as a young teen observing World War II and the Holocaust unfold. He received his B.A. from Kenyon College, Ohio; his M.A. from the University of CaliforniaBerkeley; and his Ph.D. from Johns Hopkins University. During his nearly 50-year academic career Rothchild acquired a reputation as a political scientist who crafted meaningful solutions to problems of societies beset with ethnic conflict, especially in Africa. He gained an international following among policymakers through his many stints at think tanks and universities. He was a guest researcher at the Brookings Institution and the U.S. Institute of Peace. He was awarded Fulbright and Rockefeller Foundation grants to teach at several African universities. He also taught at the School of Advanced International Studies of Johns Hopkins University. He received numerous other awards and honors, including a grant from the Carnegie Foundation to set up workshops on power sharing and peacemaking, and being named a peace fellow in the Jennings Randolph Program for International Peace for the U.S. Institute of Peace. He participated in United Nations conferences and was on the editorial boards of several academic journals. He was named the 1996–97 University of California-Davis Faculty Research Lecturer and a University of California Distinguished Professor in 2003. Rothchild was a prolific author and editor, with more than 20 books and numerous articles and chapters in edited books to his credit. He most recently co-edited the 2006 book Africa-U.S. Relations: Strategic Encounters.


D-galactose specific lectins purified f,-om Ascidia malaca serum contaill a major protein component with an apparent molecular weight of about 58,000 daltons, which moves more rapidly under non-reducing condit ions. Intramolecular disulfide linkages can explain this behaviour, suggesting a compact protein struc ture. Membrane lectins have been demonstrated on the surface of about 34% hemocytes by immunofluorescent methods using a rabbit antiserum against the isolated serum lectins. Small, medium and large hemocytes can be positive, as also shown by binding on Sepharose spherules or by rosette formation Hith sheep and rabbit erythrocytes. Binding is inhibited by the same sugars specific for the se'-um lectins. Finally, antibodies to the serum lectins specifically aggluti nate the hemocytes. This evidence supports the hypo thesis that a lectin with the same specificity and certain structul-al similarities can be f"ound f,-ee in the serum and present on hemocyte surfaces.


Preface Publications of Burcht Pranger Contributors Part 1: Literary Imagination 1. "Movesi un vecchierel canuto et bianco...": Notes on a Sonnet of Petrarch, Peter Cramer 2. Moments of Indecision, Sovereign Possibilities: Notes on the Tableau Vivant, Frans-Willem Korsten 3. History and the Vertical Canon: Calvin's Institutes and Beckett, Ernst van den Hemel 4. Christ's Case and John Donne, "Seeing through his wounds": The Stigma of Martyrdom Transfigured, Anselm Haverkamp 5. Playing with History: The Satirical Portrayal of the Medieval Papacy on an Eighteenth-Century Deck of Playing Cards, Joke Spaans 6. From East to West: Jansenists, Orientalists, and the Eucharistic Controversy, Alastair Hamilton 7. Labouring in Reason's Vineyard: Voltaire and the Allegory of Enlightenment, Madeleine Kasten Part 2: The Canon 8. The Search for the Canon and the Problem of Body and Soul, Piet de Rooy 9. Music at the Limits: Edward Said's Musical Elaborations, Rokus de Groot 10. The Canonisation of the Medieval Past: England and the Continent Compared, Peter Raedts 11. Scholarship of Literature and Life: Leopold Zunz and the Invention of Jewish Culture, Irene Zwiep 12. Censorship and Canon: A Note on Some Medieval Works and Authors, Leen Spruit 13. Does the Canon Need Converting? A Meditation on Augustine's Soliloquies, Eriugena's Periphyseon, and the Dialogue with the Religious Past, Willemien Otten 14. Between Pedagogy and Democracy: On Canons and Aversion to Conformity in Ordinary Language Philosophy, Asja Szafraniec 15. On the Significance of Disagreement: Stanley Cavell and Ordinary Language Philosophy, Paola Marrati 16. Fast Forward, or: The Theologico-Political Event in Quick Motion (Miracles, Media, and Multitudes in St. Augustine), Hent de Vries Part 3: The Christian Middle Ages 17. Tangere autem corde, hoc est credere: Augustine on 'Touching' the Numinous, Giselle de Nie 18. The Fame of Fake, Dionysius the Areopagite: Fabrication, Falsification and the 'Cloud of Unknowing', Bram Kempers 19. Two Female Apostolic Mystics: Catherine of Siena and Madame Jeanne Guyon, Bernard McGinn 20. De obitu Valentiniani: Abelard, Bernard of Clairvaux, and the Canonization of Ambrose of Milan on Baptism by Desire, Marciaa L. Colish 21. The 'Whole Abelard' and the Availability of Language, Babette Hellemans 22. Tempus longum ... locus asper ... : Chiaroscuro in Hugh of Saint-Victor, Ineke van 't Spijker 23. Obedience Simple and True: Anselm of Canterbury on How to Defeat the Devil, Arjo vanderjagt 24. The Monastic Challenge: Remarks, Helmut Kohlenberger Index of Personal Names


Tomato landraces are still cultivated for local use and consumption in many regions of the world. They frequently have distinctive organoleptic traits and nutritional value. Landraces are highly heterogeneous as they were systemically selected for their performance in adverse agricultural environments The objectives of this work was to assess a set of 15 Romanian tomato landraces collected from Timis County, regarding the yield components, in order to identify some genotypes which might be used in breeding programs. According with the results of this study we can say that there is a considerable variability between landraces regarding the plant yield and its components, which can be harnessed in tomato breeding programs. Some of the landraces like Gradinari, Livezile 498, Periam 48, Sanmartinu S. 180b, with high yield potential could be selected for further research and utilization. Also, in order to a more effective capitalization of the harvest, are worthy of being taken into account the following landraces: Pordeanu 18, Crai Nou 26 and Tarnova 360 who showed a very good precocity.


Virgin Coconut Oil (VCO) contains high medium-chain fatty acids that are functional to improve the health or as supplemen. This study aim of this research was to determine the antioxidant activity of Virgin Coconut Oil and Virgin Coconut Oil Emulsion with different sweetener. Antioxidant activity of Virgin Coconut Oil was due mainly of Phenolic compound. The major phenolic acids were ferulic acid and p-coumaric acid. Emulsion was more palatable than oil form, because oily taste is not convenient for the consumer or patient, so the sweetener. Virgin Coconut oil emulsion contain of VCO, Xanthan gum, orange juice and different sweetener. Sorbitol, Honey, Gukocose as sweetener. The Antioxidant activity of the Virgin Coconut Oil and Virgin Coconut Oil Emulsion were measured by βcarotene bleaching method. The result showed that all sample Virgin Coconut Oil, Virgin Coconut Oil emulsion with honey, with sorbitol, sith glucose, emulsion without sweetener have an antioxidant activity with Antioxidant activity (AA) 56.2%., 63.2%, 70.5%; 37.1%. 57.1% respectively and Quarsetin as a control was 92.5%.%. These data confirmed that the VCO Emulsion with sorbitol as sweetener has the highest activity of antioxidant.


Ant colony optimization is a bionic optimization algorithm that simulated real ant colonies.This paper introduced the fundamentals of ant system,gave C program to solve TSP,and analyzed the time complexity.


We report the nondiffractive propagation of acoustic waved in sonic crystals, e.g., acoustic media with periodic modulation of the material parameters (density and bulk modulus). Such novel materials have recently attracted a great interest, because of their potential applications in the control of sound propagation, used as reflectors, focusers or waveguides. All these properties are related with the dispersion introduced by the crystal anisotropy. In particular we consider the case of two-dimensional sonic crystals, consisting, e.g. in an array of steel cylinders in water. It is shown that, for given frequencies and directions of incidence, a narrow sonic beam can propagate without diffractive broadening. Such nondiffractive sonic beams exist in crystals with perfect symmetry, and do not require the presence of defects, differently from other waveguiding phenomena reported previously. The cancellation of diffraction occurs at frequencies and wavevectors for which dispersion curves (isofrequency lines) have zero curvature, i.e, are locally flat. By means of perturbative techniques, a simple analytical expression for the nondiffractive conditions has been obtained. The phenomenon is also demonstrated by numerical integration of the acoustic equations using the FDTD technique. We present experimental evidence of the nondiffractive propagation in a periodic array of steel cylinders in water. INTRODUCTION Sound crystals (SCs) are periodical structures of scatterers in an homogeneous medium, i.e. are media with periodical modulation of their acoustical properties. The study of SCs was stimulated by the previous results in other field like optics [1], that permitted to use the so called photonic crystals to design materials with band gaps for the light propagation and to construct photonic crystal waveguides, and early similar results were obtained in the field of acoustics [2]. One of the most studied properties of the SCs is the existence of prohibited propagation acoustical frequency bands. These bands correspond to frequencies for which the acoustic wave does not propagate inside the crystal but it is reflected. Therefore the SCs are good candidates to manipulate band gaps and create waveguides and isolators. Most of the studies about SCs are devoted to the case of one dimension structures, what permits some analytical treatment, in opposition to the multidimensional cases which properties are numerically investigated either through the plane wave decomposition or finite difference methods. Also the major part of them concern only about the temporal dispersion properties introduced by the crystal. We have focused our studies in the bidimensional case and demonstrated in a recent work [3] that the crystal modifies the spatial dispersion relation ( ) ⊥ = k k z , ω ω with ( ) y x k k k , = ⊥ . The group velocity of each component is determined by the gradient of the frequency in k-space, ( ) k v k g ω ∇ = . As a consequence, for a given frequency the power propagates along theperpendicular direction of the spatial dispersion relation or equifrequency surfaces ( ) ⊥ = k f k z . During a finite distance l the phase accumulated by any


The crochet knitting machine is a warp knitting machine with a weft insertion system placed on a weft guide bar. On standard machines, the weft guide bar is made from aluminum and weighs about 570 g. The single-drive motors, which power the bar, account for 15–20% of the machines total power consumption. The aim of this research was to reduce power consumption by decreasing the mass of the weft guide bar. This was done by constructing the bar from carbon fiber reinforced plastics rather than aluminum, resulting in a mass saving of 260 g.


This study sought to compare the effects of morphine, bupivacaine, and saline injected into the knee after ar throscopic surgery. In a double-blind, randomized trial, 124 patients received either bupivacaine, morphine, bupivacaine and morphine, or saline at the completion of surgery. Postoperative pain was assessed with a 100-mm visual analog pain scale. Analgesic require ments were calculated, and weightbearing status was recorded. We found that morphine alone injected in traarticularly at the completion of arthroscopic knee sur gery had no significant effect on postoperative pain, need for supplemental analgesia, or weightbearing sta tus. Patients receiving morphine in combination with bupivacaine did not demonstrate any statistically sig nificant improvement over those receiving bupivacaine alone. Therefore, our results failed to show any ben eficial effect of morphine used for postoperative anal gesia, either alone or in combination with bupivacaine. The overall pattern in all patients demonstrated de creased pain scores, decreased analgesic use, and in creased weightbearing status as the observation period progressed. Finally, preoperative pain was correlated with pain at discharge, indicating that the most signifi cant predictor of postoperative pain was preoperative level of discomfort.


The changes in scholarly communication as a result of infusion of information technology in research work over the years imply that additional competencies and skills in scholarly communication are required for librarians to effectively support scholars in scholarly communication. This paper sought to identify the competencies and skills needed by academic librarians in Nigeria particularly in terms of their knowledge, understanding, and abilities in four main categories of the emerging scholarly communication activities, viz, scholarly publishing services, open access repository, copyright and open access, and assessing scholarly resources. This is with a view of making appropriate recommendations to address the needs identified. The study used a quantitative approach to data collection and analysis. A total of 80 academic librarians from the Nigerian Library Association online forum were used as sample population. The study discovered among others, that a high percentage of the academic librarians had knowledge of commercial and open access publishing platforms and open access policies and copyright. On the other hand, a low percentage had knowledge of funder mandate and requirement as well as bibliometric and altmetrics theory and practices. While more than half of the academic librarians in Nigeria had an understanding of current trends, issues in open access and assessment of scholarly resources, a low percentage had an understanding of data curation and management activities. Many academic librarians lack abilities to liaise with publishers on issues relating to archiving policies including embargo period and data management among others. The paper recommends the inclusions of courses in the Nigeria Library Schools curriculum that will build competencies and skills in scholarly communications. Nigerian Library Association and Librarian Registration Council are also encouraged to organize workshops and conferences that will also build competencies and skills in scholarly communication.


corresponding author Type of Work: Peer Reviewed. DOI: http://dx.doi.org/10.21013/jmss.v16.n1.p1 How to cite this paper: Ladifatou GACHILI NDI GBAMBIE, Ousseni MONGBET. (2020). Conditional Efficiency of Official Development Assistance (ODA) on Economic Growth in Sub-Saharan Africa. IRA-International Journal of Management & Social Sciences (ISSN 2455-2267), 16(1), 1-22. doi:http://dx.doi.org/10.21013/jmss.v16.n1.p1


Chronic illness is not easy to deal with not only because of the nature of the disease or its treatment. The government, in this case, has sought to provide various health facilities to realize a healthy and efficient society, as stated in the National Health Insurance program and implemented in a program, namely the chronic disease management program (PROLANIS). The aim of the study was to determine the relationship of knowledge and family support with the level of adherence to the program of managing chronic diseases (prolanis) in the working area of Kampung Dalam Health Center in Padang Pariaman Regency in 2018. This study was a descriptive analytical study using the cross-sectional method. This research was conducted in the work area of Pariaman Health Center, Kota Pariaman from June 29 to July 20 in 2018. The study population was 40 people, consisting of 5 people with diabetes mellitus patients and 35 hypertensive patients. Total sampling technique The results of this study analysis show that 67.5% have low knowledge. 57.5% have low family support. 70% have non-compliance in participating in the Chronic Disease Management Program (PROLANIS). There is a significant relationship between knowledge and compliance following the Chronic Disease Management Program (PROLANIS), with p-value obtained at 0.008. There is a significant relationship between family support and adherence to participating in the Chronic Disease Management Program (PROLANIS), with p-value obtained at 0.018. It is expected that respondents pay more attention to food consumption, try to reduce the consumption of foods that taste salty and excessive fat, regular exercise schedules should be applied every day and more time to take part in the activities held in the Prolanis program.


Our understanding of the relationship between innovative capacity, social ca-pital and the social dimension of sustainable development is still in its infan-cy. There is an extensive literature on ...


A simple and sensitive method for the determination of humic acid has been developed. The method is based on the adsorptive enrichment of humic acid using a finely divided anion-exchange resin, collection of the resin on a membrane filter by filtration as a circular thin-layer, and direct measurement of the absorbance of the resultant thin-layer of resin by densitometry at 470 nm. Up to 80 µg of humic acid in 100 ml of sample solution can be determined, the limit of detection being 1.3 µg. The effect of iron(III) is masked with ethylenediaminetetraacetic acid (EDTA). Iron(III) is also determined by densitometry at 600 nm after enrichment on the thin-layer of resin as a complex with ammonium pyrrolidine dithiocarbamate (ammonium pyrrolidin-1-yldithioformate)(APDC), the limit of detection being 0.06 µg of iron(III). In the presence of humic acid, the blank value is obtained by masking the iron(III) as the EDTA complex, and calculating the net absorbance due to the APDC complex. The methods have been used to investigate the effect of humic acid on the formation of filterable iron(III) species, which can pass through a 0.45 µm membrane filter. The possibility of characterizing humic acid based on the formation of a complex with iron(III) has been shown.


UCLA Working Papers in Phonetics No. 106, pp. 34-40 THE DISTRIBUTION AND REALIZATION OF H TONES IN BENGALI Sameer ud Dowla Khan UC Los Angeles firstname.lastname@example.com ABSTRACT The current study examines the realization and distribution of high (H) tones in Bengali across different sentence types and under varying focus domain sizes, to show that Bengali tonally marks three prosodic phrases above the word instead of two – Intonation Phrases (IP), Intermediate Phrases (ip), and Accentual Phrases (AP) – and that focus realization can be derived without the lexically-specified tonal morphemes or the additional stipulations on prosodic boundary placement proposed in previous models. Keywords: Bengali, prosody, focus, intonation. 1. INTRODUCTION Previous studies [5, 6, 8, 14, 16] claim that focus domains in Bengali are marked by a small prosodic unit bounded by a high (H) tone at its right (R) edge. This same unit is also claimed to mark edges of non-phrase-final content words, even under neutral focus. Using Bengali data gathered in a production experiment, the current study examines the realization and distribution of H tones claimed to be associated with various phrase edges and with focus domains, to investigate the prosodic structure and focus realization in the language. Phrasing According to previous studies [5, 6, 8, 9, 14, 16], Bengali assigns tones to stressed syllables of content words and to the R-edges of two prosodic units: the intonation phrase (I-phrase or IP) – roughly, the sentence – and a smaller phrase, slightly larger than a content word. This smaller phrase is given various labels, provided in Table 1. Table 1: Prosodic units in various studies of Bengali. Study Sentence-level prosodic unit pause group intonation phrase intonation phrase intonation phrase intonation phrase Phrasal-level prosodic unit stress group phonological phrase accentual phrase intermediate phrase major phrase


Comparison of temperature and hydrodynamic models for high electron mobility transistors has been carried out. It is shown that the real space transfer in the transistor heterostructures and the strongly energy dependent relaxation times are mostly responsible for the spectacular difference in calculations for HEMT with gate length sufficiently greater than momentum relaxation length. The temperature model may lead to more than 20% error in current and transconductance, beginning from length as long as 0.5/spl mu/, which markedly exceeds the gate length characteristic to modem HEMT. The different models produce a big difference in the drift velocity distribution in the transistor channel, especially when the channel is open and the real space transfer is considerable. The reasons for this effect are as follows: the lateral size of the quantum well is much less than electron momentum relaxation length and electron current flowing transverse to the heterostructure border is really high, even in comparatively low fields. The electron density in the quantum well strongly depends on transverse electron current, which is different for the temperature and hydrodynamic models. For example, in In/sub 0.52/Al/sub 0.48/As-In/sub 0.53/Ga/sub 0.47/As HEMT with 1/spl mu/ gate length, the drift velocity under the gate is 30% more in the temperature model than in the hydrodynamic model.


Though the choices of terrorists' attack targets are vast, their resources are limited. In this paper, a game-theoretical model is proposed to study both the defender's (government) and the attacker's (terrorist) expenditures among multiple targets under budget constraints to guide investment in defense. We study how the defender's and the attacker's equilibrium allocations depend on the budget constraints, target valuations, cost effectiveness of their investments, and inherent defense levels of targets in both sequential-move and simultaneous-move games. The equilibrium solutions are provided using the Karush–Kuhn–Tucker conditions. At the subgame-perfect Nash equilibrium, the defender's total marginal effects are the same among targets. Moreover, the defender's total marginal effects can be decomposed into direct and indirect effects. We also use the multiple-infrastructure and multiple-urban-area data sets to demonstrate the model results. The regression analysis shows that both the attacker's and the...


BACKGROUND: In addition to the common ABO phenotypes, numerous phenotypes with a weak expression of the A or B antigens on red blood cells have been found. DNA genotyping on A 3 e A 3 B subgroups has been performed in small number of samples, mainly in family studies. To date, seven ABO alleles have been associated to A 3 and A 3 B subgroups ( ABO*A301 to ABO*A307 ) revealing molecular heterogeneity. Our purpose was to study molecular events on exon 7 of ABO gene in 100 A 3 and A 3 B blood donors samples. STUDY DESIGN AND METHODS: ABO serologic analyses of 12,283 blood donors of blood groups A and AB allowed the detection of 13 A 3 and 87 A 3 B samples. Initially, DNA amplification was performed using sequence specific polymerase chain reaction (PCR-SSP) to identify 467C>T, 829G>A, 871G>A and 1060delC polimorphisms of exon 7 of ABO gene, followed by direct DNA sequencing. RESULTS: New ABO variants were detected in 5/13 (38.5%) of A 3 and in 38/87 (43.7%) of A 3 B samples. ABO* A302/ABO*A301 genotype was found in 30.7% A 3 and, ABO* A302/ABO*B104 in 17.1% of A 3 B samples. The 871G>A mutation previously reported only in A 3 B individuals was found in 9 blood samples tested as A 3 in our study. For the first time, mutations between 441–450 nucleotides of exon 7 of ABO gene was detected in 39 samples (single nucleotide polimorphisms and deletions) of A 3 and A 3 B subgroups. CONCLUSION: This is the first large molecular study of A 3 and A 3 B samples. Sistematic analysis of A 3 and A 3 B samples reveals new ABO variants caused by different molecular events. Mutations between 441 and 450 nt. of exon 7 are critical for transferase A expression in individuals typed as A 3 and A 3 B.


Biomonitoring is a significant tool of environmental protection strategies. Variety of bioindicators are used worldwide, particularly mosses, lichens and tree leaves. However, they revile many considerable disadvantages, e.g. limitation to vegetative season, moisture demand, exposition to severe weather conditions, limited time of monitoring. Classical impactors, on the other hand, are expensive, cannot be used without supervision and allow only for short-term monitoring. Spider webs, however, reveal features of extraordinary bioindicators. Webs are abundant, easy to collect, costless and can be found all year round, despite vegetative season. Spider silk is a very efficient, non-selective accumulator of contaminants, that allows for long-term monitoring. Thanks to this characteristics, spider webs proved to be immensely useful bioindicators of air pollution. They allow for monitoring of heavy metals, Polycyclic Aromatic Hydrocarbons (PAHs), dioxins, so as assessment of mutagenic activity and anthropopression assessment and indication of dominant source of pollutants. Most of the researches concerning application of spider webs as bioindicators have been conducted in Wroclaw, Poland. This paper reviews current knowledge on spider webs in monitoring of air pollution.


This paper introduces the problems existing in the loading section of the belt conveyer, analyzes on some treating methods, and puts forward some more scientific solving methods.


The study investigates protective responses in low probability and high loss risk situations. Particularly, it (1) detects individual protection valuations to variations in probability versus to variations in loss for payment decisions and choice decisions, (2) elicits the threshold probability in individuals' minds that make them consider having protective measure, (3)calculates relative risk aversion. The results of the experiment indicate that as the probability of loss and loss amount increases, individuals tend to buy/pay more for protection. They are more responsive to the variation in probabilities than to the variation in loss amounts when they decide whether to buy the protective measure or not: choice decision. Yet, the opposite is true when they decide the amount of willingness to pay for buying the protective measure: payment decision. In addition, bid expected loss values have a bimodal distribution. Consistent with previous studies, individuals (particularly women) are found to be risk averse for low probabilities.


A novel image sequence segmentation method which combines both spatial and temporal information is presented in this paper. The first step is an intensity segmentation scheme based on the edgeflow method. The temporal information is introduced through three-dimensional (3-D) motion estimation parameters. In the second step, regions obtained from the first step are clustered according to their 3-D motion models. In order to reduce the noise sensitivity of the motion estimation process, we introduce a robust method which produces accurate motion parameters and facilitates the correct clustering that follows. This ensures that rigid objects with luminance discontinuities can be segmented correctly. The method has been successfully tested in real imagery and typical examples are presented in this paper.


Using a primary dataset from an experimental survey from eight European cities, this study identified the key determinants of satisfaction on individual trip stages as well as the whole journey experience for different travel modes and travellers' groups. Multivariate statistical analyses were used to examine the relations between overall satisfaction and travel experience variables, subjective well-being indices, travel-related attitudes as well as individual- and trip-specific attributes. The results indicate that certain travellers groups such as women, young and low income or unemployed travellers have distinctive determinants of satisfaction with trip stages for various travel modes. For example, at public transport trip stages, the ease of transfer, station environment, service frequency and travel time reliability are the key determinants of travel satisfaction, whereas waiting safety is an important determinant for women travellers. The results also indicate that the satisfaction with the primary trip stage is strongly linked to the overall trip satisfaction, while the access and egress trip stages have a very marginal contribution to the overall satisfaction. However, the satisfaction levels with access and egress trip stages are strongly related to the satisfaction with the primary trip stage and hence might indirectly be reflected through it. Past experience, travellers' expectations and attitudes and travellers' emotional state are also significant explanatory variables of travel satisfaction.


OBJECTIVE
Laser lithotripsy under fluoroscopic guidance was difficult and risky due to the invisibility of laser fiber under fluoroscopy. The study aimed to investigate the feasibility of a novel endoscopic auxiliary system (NEAS)-assisted lithotripsy under fluoroscopy for difficult common bile duct (CBD) stones.

METHODS
Patients with difficult CBD stones treated with NEAS-assisted laser lithotripsy (NEAS group) or conventional mechanical lithotripsy (ML) under fluoroscopy (ML group) were retrospectively evaluated. The primary outcome was complete stone clearance rate and the secondary outcomes included operation time, complications, and costs.

RESULTS
Seventeen patients were treated with NEAS-assisted laser lithotripsy and 144 patients underwent ML. Using a propensity score-matched design, we selected 17 pairs of cases treated with NEAS-assisted lithotripsy and ML. Patients in the NEAS group showed higher stone clearance rate than that in the ML group (94.1% vs. 58.8%, p = 0.039), as well as shorter operation time (41.9 mins vs. 49.4 mins, p<0.001) and lower costs (4607 $ vs. 5014 $, p<0.001). There was no significant difference in complications between the two groups (5.9% vs. 17.6%, p = 0.601).

CONCLUSIONS
Our study indicated that NEAS-assisted fluoroscopy-guided laser lithotripsy is feasible and safe, which might be a promising technique in fluoroscopy-guided laser lithotripsy for difficult CBD stones. This article is protected by copyright. All rights reserved.


ABSTRACT Previous studies have suggested that grape and its products may possess blood pressure (BP)-lowering properties. Due to inconsistencies in results, we aimed to systematically examine the effect of grape products on BP by conducting a meta-analysis of randomized controlled trials (RCTs). PubMed, Scopus, Web of Science (ISI), and Cochrane Library databases were comprehensively searched until March 2020. Human clinical trials which reported the effect of grape products supplementation on systolic BP (SBP) and diastolic BP (DBP) were included. Data were pooled using a random-effects model and expressed as a weighted mean difference (WMD) with a 95% confidence interval (CI). Twenty-eight studies comprising a total of 1344 subjects were included in our meta-analysis. The overall outcome of the meta-analysis indicates that grape products consumption can significantly reduce SBP (WMD: −3.40 mmHg, 95% CI: −6.55, −0.24, p = .03, I2 = 93.4%) and DBP (WMD: −1.69 mmHg, 95% CI: −3.12, −0.27, p = .01, I2 = 80.4%). This meta-analysis found a moderate and statistically significant reduction for either SBP or DBP with grape products compared with controls. Additional high-quality studies are needed to further evaluate the causal conclusions.


A method for performing an investigation of an examination object in an imaging diagnostic apparatus, comprising the steps of: - selecting a stored reference image, the stored reference image is stored in association with the accompanying sequence protocol with which the reference image was generated, the flow trace having the imaging parameters and the post-processing steps, with which the reference image was generated and with which complete the postprocessing of the reference image can be reconstructed, wherein an image is to be taken from the examination object corresponding to the reference image, - determining the sequence protocol by determining the sequence protocol of the selected reference image, - Planning for taking a picture from the object to be examined on the basis of this flow protocol, the post-processing of the runtime log of the reference image is taken, and - executing the sequence protocol for creating an image from the inspection object corresponding to the reference image.


e14009 Background: Our aim was to create a quality-index assuming that high-quality trials would have a proportional relationship between PFS and OS. Methods: Randomized clinical trials (RCT) with ...


Clubbing is an important part of the nighttime economy, and cocaine use is, for some young people, an essential part of this clubbing culture. However, the interaction rituals around the use of powder cocaine in this context remain understudied. This study is based on qualitative interviews with young adult recreational cocaine users (n = 28) and explores how they use cocaine in club settings, in relation to rituals and drinking culture. The analysis identified three main explanations for using cocaine: (a) unity with friends because of shared transgression, (b) the high as a "collective effervescence," and (c) the possibility to control, extend, and intensify drinking to intoxication. These three explanations illustrate how cocaine rituals were deeply integrated in drinking-to-intoxication rituals, and how the illegality of cocaine use reinforced feelings of unity with friends. In the nighttime economy, cocaine use and its related rituals are used to intensify and control alcohol-fuelled partying.


[Extract] There are 686 large (>1875m2) waterbodies throughout the Leichhardt catchment. Prioritizing on-ground management for these waterbodies requires a 'whole-of-catchment' assessment of how waterbodies throughout the catchment are behaving over time. This report describes how three different remote sensing products have been combined to describe waterbodies throughout the Leichhardt catchment. An archive of dry season Landsat TM data was used to describe the size, distribution and permanence of individual dry season waterbodies. The same archive was also analysed to characterise the optical water quality dynamics of each waterbody, i.e. which water bodies are always clear in the dry season, and which waterbodies vary between being clear during one dry season and then turbid the next. Daily MODIS data were also used to map the extent and duration of inundation associated with the post Tropical Cyclone Larry flood event.


Sanna Sintonen Older consumers adopting information and communication technology: Evaluating opportunities for health care applications Lappeenranta 2008 187 p. incl. 2 Appendices Acta Universitatis Lappeenrantaensis 326 Diss. Lappeenranta University of Technology ISBN 978-952-214-656-4, ISBN 978-952-214-657-1 (PDF), ISSN 1456-4491 The purpose of this dissertation is to analyse older consumers' adoption of information and communication technology innovations, assess the effect of aging related characteristic, and evaluate older consumers' willingness to apply these technologies in health care services. This topic is considered important, because the population in Finland (as in other welfare states) is aging and thus offers a possibility for marketers, but on the other hand threatens society with increasing costs for healthcare. Innovation adoption has been under research from several aspects in both organizational and consumer research. In the consumer behaviour, several theories have been developed to predict consumer responses to innovation. The present dissertation carefully reviews previous research and takes a closer look at the theory of planned behaviour, technology acceptance model and diffusion of innovations perspective. It is here suggested that there is a possibility that these theories can be combined and complemented to predict the adoption of ICT innovations among aging consumers, taking the aging related personal characteristics into account. In fact, there are very few studies that have concentrated on aging consumers in the innovation research, and thus there was a clear indent for the present research. ICT in the health care context has been studied mainly from the organizational point of view. If the technology is thus applied for the communication between the individual end-user and service provider, the end-user cannot be shrugged off. The present dissertation uses empirical evidence from a survey targeted to 55-79 year old people from one city in Southern-Carelia. The empirical analysis of the research model was mainly based on structural equation modelling that has been found very useful on estimating causal relationships. The tested models were targeted to predict the adoption stage of personal computers and mobile phones, and the adoption intention of future health services that apply these devices for communication. The present dissertation succeeded in modelling the adoption behaviour of mobile phones and PCs as well as adoption intentions of future services. Perceived health status and three components behind it (depression, functional ability, and cognitive ability) were found to influence perception of technology anxiety. Better health leads to less anxiety. The effect of age was assessed as a control variable, in order to evaluate its effect compared to health characteristics. Age influenced technology perceptions, but to lesser extent compared to health. The analyses suggest that the major determinant for current technology adoption is perceived behavioural control, and additionally technology anxiety that indirectly inhibit adoption through perceived control. When focusing on future service intentions, the key issue is perceived usefulness that needs to be highlighted when new services are launched. Besides usefulness, the perception of online service reliability is important and affects the intentions indirectly. To conclude older consumers' adoption behaviour is influenced by health status and age, but also by the perceptions of anxiety and behavioural control. On the other hand, launching new types of health services for aging consumers is possible after the service is perceived reliable and useful.


Abstract:Psychiatric diagnoses are increasingly seen as viable categories around which self and social identities might be drawn. This introduces a new pressure on the "boundary problem" for psychiatry: when members of the public request diagnoses to affirm their self-identities how should we draw the line between mental disorder and normality? If psychiatrists have the authority to recognize and diagnose mental disorder, how can roles as diagnosers and gate-keepers be balanced in a post-stigma era of mental health care? Focusing on the disorder identified would-be patient who would not attract the diagnosis they seek were they not to seek it, this essay explores what it means to have an identity bound to a psychiatric diagnosis and considers a framework for psychiatrists to negotiate clinical encounters that involve the seeking of identity affirming diagnoses.


The article presents the results of research conducted to ensure the stability of the depth of processing of suspended soil processing machines with a base wheel on the example of a mounted plow and a chisel-cultivator. It is noted that for the operation of the suspended soil processing machines with a base wheel to sink to the specified depth, and for a stable (uniform) walk at this depth, their base wheels must be continuously pressed against the field surface. This should be provided for the calculation of changing the steep distances from the base plane to the increase in the steep distances from the base planes of the mounted plow and chisel-cultivator to the bottom hanging points in the experimental studies conducted on the vacant areas of the experimental farm of the institute. This has led to an increase in the processing depth and a decrease in its average square deviation. According to the results obtained from the where, the base wheels of the mounted plow and chisel-cultivator should be pressed against the field surface. Hence, the steep distance from the base plane to the bottom hanging points should be between 78-83 and 63-68 cm respectively to work at the specified depth and to move.


Abstract
Background: Wolfram syndrome is a genetic condition, which is typically inherited in autosomal recessive fashion, characterized by the combination of diabetes mellitus and optic atrophy. It is along a spectrum


According to major two engineering geology problems of huanghe highway third bridge, which are falling loess in south bank and saturated sandy soil earthquake liquation of second sandy soil, it analyzes discusses them and puts forward relative treatment measures.


The project emerges when a substantive change in the concept of family is observed in the present times; new conformations are emerging, and interdisciplinary work has thus become increasingly important when working with families. The present research's goal is to learn about the characteristics of the interdisciplinary approach in relation to the new family conformations and difficulties from the perspective of the social workers, as well as their social representations about the conformations. The final conclusions that emerged from the research indicate that social workers find multiple conformations, mainly assembled families, and a large amount of single parent families and adolescent mothers; traditional nuclear families are no longer predominant. Professionals show a high level of acceptance of these new conformations, although yet prejudice -more or less explicitly- is still present, and determines courses of action. In general, social workers do not observe a greater incidence of dysfunction in new conformations, showing acceptance towards them, which does not mean that older paradigms have stopped operating unconsciously. Social acceptance of these new conformations is essential to prevent rejection and marginalization from pushing these families into dysfunction, by way of the self-fulfilling prophecy. The most frequent problem is violence, in all its manifestations. In second place, appear abandonment and neglect towards children and elders; followed by addictions and crime. Social workers value interdisciplinary work. It allows them to save time, to increase efficiency, to complement knowledge, and to provide support and acknowledgement. It has been observed that intra-institutional interdisciplinary work is more frequent than articulation between institutions, with lack of formal intervention protocols. Social workers observe a trend to the paradigm shift, from a positivist approach with traditional professions hegemony to an integrative approach that includes different professions working in cooperation. Finally, gender was a topic present in all intervention areas. Women are considered selfless carers. This is reproduced in social work, where social workers lack any protection that may palliate their high exposition level.


A test was conducted to examine the effect of several electron donors such as glucose, sodium acetate, Fe0, Fe0+glucose and Fe0+sodium acetate on reductive dechlorination of 2,4-dichlorophenol (2,4-DCP) through inoculating the unacclimated anaerobic mixed bacteria. The optimum condition and sus-tainability of Fe0 as electron donor was also been discussed. The results showed that, Fe0+glucose enhanced the dechlorination of contaminant effectively compared to glucose. Sodium acetate, Fe0 and Fe0+sodium acetate were all effective electron donors and Fe0 was the optimum, the optimum initial pH was 8.0 and quantity of added Fe0 was 2.0 g/L. 4-CP was the mainly intermediate product for 2,4-DCP dechlorination. Fe0 could support the electron for reductive dechlorination of 2,4-DCP continuously. In contrast, when so-dium acetate as electron donor, the effect of dechlorination was inferior to Fe0 with the consumption of sodium acetate.


Competition between nation and nation is based upon competition between their actual economic abilities, which is mostly focused competitionof a person's ability. Key factor of U. S economic effective development related to sending far and wide to invite talented person. Result of which come across from enduring and overall winning over talents. Both overseas Chinese and students should be invited.while men with current ability should be utilized, developed, excavated and trained for Chinese economic uprising. Development of Chinese economy, particularly effective circulating for that of a enterprise should be implemented through setting up reservoir of talent and market of human resource to make the best possible use of men and endeavor to the best of one's ability.


A person's name is at once a central marker of personal identity (including gender identity), a linguistic artifact, and a label used to identify individuals at all levels of social organization. Legal monitoring of personal name choice correlates with aspects of state formation and centralization.


Amorphous Tb/Co compositionally modulated films were deposited on Si substrates with different modulation layer thicknesses ranging from about 2.5 to 15 A. The nominal Tb to Co layer thickness ratios were systematically varied and the complex refractive index (n and k) and polar magneto‐optical Kerr effects (rotation and ellipticity) were measured in the 3000–8000‐A spectral range as well. The samples were divided into two groups. In one group, the thickness of the Co layers was fixed, the Tb layer thickness varied. In the second group, the thickness of the Tb layer was fixed, and that of the Co layer thickness varied. The Kerr rotation and the coercivities of the samples showed very consistent and interesting changes. X‐ray diffraction and x‐ray fluorescence were also performed on the samples, which revealed layered structures, or compositional modulation, and provided information on the Tb to Co atomic ratios in the samples.


Application of the organic manures hada significant influence on nutrients uptake by potato at different growth stages. The tubers accumulated more nutrients while uptake by haulms declined with maturity. Application of farmyard manure (FYM) and mushroom spent compost (MSC) appreciably enhanced the N, Fe and Zn uptake which were almost comparable in their effects whereas the P uptake was significantly increased by FYM. MSC application significantly enhanced the uptake of K, Ca and Mg by potato shoot and Mn uptake by both shoot and tuber. All the manures were comparaole in tuber uptake of K, Ca and Mg.


Surface sediment samples from Mljet Lakes and adjacent open sea (south-eastern Adriatic coast, Croatia) were analyzed for stained and total foraminifer content in relation to water depth and substrate characteristics. Foraminifer distribution changes substantially in a short distance. The assemblages from muddy substrate samples are predominantly hyaline, poor in term of specimens and species. The assemblages from sandy substrate samples consist of abundant permanently mobile porcelaneous species, rich in number of specimens and species. Primary conclusion of this study is that the shallow-water foraminiferal distribution in this peculiar environment is governed by a complex interaction between several environmental constrains (enclosed nature of the Mljet Lakes , its particular hydrography, occasional anoxia). Reduction of foraminiferal species observed in a 10 years period suggests dynamics of environmental conditions reflected in changed microhabitats. In spite of the peculiarity of the investigated area, the observed pattern of foraminiferal distribution might be useful in paleoenvironmental interpretation.


Planet-induced substructures, like annular gaps, observed in dust emission from protoplanetary disks, provide a unique probe for characterizing unseen young planets. While deep-learning-based models have an edge in characterizing a planet's properties over traditional methods, such as customized simulations and empirical relations, they lacks the ability to quantify the uncertainties associated with their predictions. In this paper, we introduce a Bayesian deep-learning network, "DPNNet-Bayesian," which can predict planet mass from disk gaps and also provides the uncertainties associated with the prediction. A unique feature of our approach is that it is able to distinguish between the uncertainty associated with the deep-learning architecture and the uncertainty inherent in the input data due to measurement noise. The model is trained on a data set generated from disk–planet simulations using the fargo3d hydrodynamics code, with a newly implemented fixed grain size module and improved initial conditions. The Bayesian framework enables the estimation of a gauge/confidence interval over the validity of the prediction, when applied to unknown observations. As a proof of concept, we apply DPNNet-Bayesian to the dust gaps observed in HL Tau. The network predicts masses of 86.0 ± 5.5 M ⊕, 43.8 ± 3.3 M ⊕, and 92.2 ± 5.1 M ⊕, respectively, which are comparable to those from other studies based on specialized simulations.


Purpose: The purpose of this study is to examine the effects of X-ray beam angulation on the fractal dimension of trabecular bone structure of human dry mandible using the tile counting method. Materials and Methods: We divided 5 human dry mandibles into an angle and a molar groups depending on the regions and deciding the region of interest (ROI). When contrasted with the ROI, the inferior cortex was appointed to be low and the lines perpendicular to the buccal cortex were appointed to be the standard angle. Direct digital intraoral radiographs were obtained from 9 different projection angles. We analyzed statistically the fractal dimension using the tile counting method. Results: There was a statistically significant difference in the fractal dimension of the regions and the mandibles, but there was no statistically significant difference in the fractal dimension according to the X-ray beam angulation. Conclusion : There is no statistically significant effect of the angle of the projection on the fractal dimension of trabecular bone structure of a human dry mandible according to the tile counting method.


According to the 3GPP LTE technical specification and research background and meaning,introduced the LTE access network EUTRAN of air interface architecture briefly.Then,respectively from the physical layer,data link layer and wireless resource control layer studied TD-LTE wireless interface protocols.


BACKGROUND: We aimed to assess whether lipiodol alters endometrial gene expression through a uterine bathing effect that might enhance receptivity to embryo implantation. METHODS: An open-label randomised controlled trial design in a single-centre tertiary infertility service. Twelve women with endometriosis (n [Formula: see text] 11) or previous successful lipiodol procedure (n [Formula: see text] 1) were randomised to receive immediate or delayed lipiodol hysterosalpingography, followed by endometrial biopsy. Endometrial samples were assessed for gene expression, using Affymetrix microarrays and validation studies using reverse transcriptase quantitative polymerase chain reaction analysis. Subsequent endometrial gene expression responses to treatment and clinical fertility outcomes were assessed. RESULTS: Eleven of 12 women had successful endometrial sampling procedures. Nine women had successful pregnancies within the 9-month follow-up phase. Following lipiodol bathing we identified 20 down-regulated and 13 up-regulated genes with p [Formula: see text] 0.05 and with magnitude of change [Formula: see text]1.5-fold in at least three of the four women, with osteopontin being the only gene down-regulated in all four women. CONCLUSIONS: This study supports the concept of a uterine bathing effect of lipiodol altering endometrial biology and gene expression. Whether regulation of inflammation and immune response pathways by lipiodol might contribute to an increase in endometrial receptivity to embryo implantation merits further investigation.


Retributi0n is a regi0nal collection as payment f0r services 0r the granting 0f certain permits from the regional government to individuals or entities. The reas0n f0r this research is that the Bandung City TPU has a mismatch of funeral retribution rates with Bandung City regulations and burial grounds that are n0t in acc0rdance with the Bandung City Data Portal. The meth0d used in this study is a descriptive meth0d with a quaIitative appr0ach. Data coIIecti0n techniques used in this study thr0ugh, 0bservation, interviews and d0cumentati0n. The determination 0f inf0rmants was carried out t0 TPU officers and the people who were met at the research location. The resuIts 0f this study indicate that the effectiveness 0f the policy related to the Bandung City Regional Regulation Number 3 of 2017 concerning Cemetery Service Fees in the City of Bandung is quite effective, these results were obtained through interviews with resource persons from TPU Pandu, TPU RancaciIi, TPU Maleer, TPU Cikutra and TPU Astana Anyar. . By coordinating between TPU officers, the Cipta Karya, Construction Development and Spatial Planning and people who use TPU, it is h0ped that there wiII be an increase in effectiveness.


To the Editor: A 57‐year‐old male presented to the clinic with a 1‐year history of mass underneath his left fourth fingernail. Notably, he reported trauma to the subungual area of the fingernail 5 years ago. Thereafter, it did not heal and a mass emerged with tenderness, periungual swelling, and redness. A mycologic evaluation was negative. Then, topical antibiotic was prescribed. However, the mass enlarged gradually, with bleeding, ulceration, and crust. The patient had been smoking 20 cigarettes per day for 11 years, from age 21 to 32 years old, while no smoking since than.


In this paper, we used random generalized variational-like inequality problem and establish a new gap function for this problem in a fuzzy environment. In addition, we used this gap function, to evaluate an error bound for random generalized variational-like inequality problem in a fuzzy environment.


Regional Differences in Mortality in the Netherlands, 1850-1930. Continuity and Change.
Research by J. P. Machenbach et al (Regionale sterfteverschillen. Een bundel met artikelen ten behoeve van het symposium "Regionale sterfteverschillen" d.d. 9 november 1990 te Rotterdam [Regional Differences in Deaths: A Collection of Articles from the Symposium "Regional Differences in Deaths" held 9 Nov 1990 in Rotterdam] Rotterdam: Instit. Maatschappelijke Gezondheidszorg Eramus Univ, 1990) shows a relationship between the mortality rate and % of Catholics and between income level and degree of urbanization in 39 Dutch regions from 1950 to 1984. Multivariate analysis of regional data shows a similar correlation between the mortality rate and these factors for 1850-1859, 1885-1894, and 1928-1938. Since 1880 the % of Catholics is positively correlated with the mortality rate. The relationship between mortality rate and religion is discussed. 1 Table, 3 Figures, 1 Map, 53 References. Adapted from the source document.


A major obstacle for all cell therapy of solid tumors has been the ability of adoptively transferred cells to infiltrate into immunosuppressive solid tumor microenvironments. In this study, we developed a method of differentiating and expanding a novel subset of tissue-resident natural killer (NK) cells and assessed their capacity to infiltrate head and neck squamous cell carcinoma (HNSCC) and control tumor growth in vivo. In previous work, single-cell RNA sequencing was performed to profile the entire innate lymphoid cell (ILC) family of lymphocytes (including NK cells) isolated from primary human head and neck squamous cell carcinoma (HNSCC). This revealed multiple subsets of NK cell and ILC states within the tumors. A particular NK cell state, resembling intraepithelial ILC1s (ieILC1), expressed integrins characteristic of tissue residency (such as CD103) and expressed the highest levels of granzyme A, granzyme B, and perforin, suggesting potent cytolytic activity. In the current study, we investigated the potential of these cells for adoptive cell immunotherapy against solid tumors, such as HNSCC and melanoma. Using a co-culture system, we developed a method to differentiate and expand a highly purified population of human CD103+ ieILC1-like NK cells ex vivo to clinically relevant numbers. In vitro impedance-based killing assays were used to assess and demonstrate that these cells have superior cytolytic activity against a variety of epithelial target cells, compared to conventional NK cells. In vivo mouse models using xenografts of HNSCC and melanoma in NSG mice were used to assess and demonstrate superior capacity of ieILC1-like NK cells to control tumor growth compared to conventional NK cells from the same donor. Importantly, the CD103+ ieILC1-like NK cells were able to infiltrate the tumor microenvironment significantly better than conventional NK cells, which likely contributed to their potent control of tumors in vivo. Thus, these findings introduce a novel subset of immune cells that have efficient tumor-infiltrating capacity and potent cytolytic activity for adoptive cell therapy of solid tumors. Because conventional NK cells have already demonstrated clinical activity, these preclinical data indicate that CD103+ ieILC1-like NK cells warrant investigation in the clinic.
 Citation Format: Nina B. Horowitz, June Ho Shin, Sainiteesh Maddineni, Imran A. Mohammad, Alice Xinyuan Liu, John B. Sunwoo. Leveraging tissue-resident CD103+ NK cells for adoptive cell therapy in head and neck cancer [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Innovating through Basic, Clinical, and Translational Research; 2023 Jul 7-8; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2023;29(18_Suppl):Abstract nr PO-091.


FOURTEEN cases of aregenerative anemia associated with benign thymoma have been reported to date in the medical literature.1 2 3 4 5 6 7 8 9 10 11 The present report adds 2 cases of the syndrome and describes an experimental attempt to produce anemia with an extract of the thymoma from 1 of the patients. The report of Humphreys and Southworth5 in 1945 first emphasized the fact that the association of thymoma and aregenerative anemia could not be ascribed to chance. They reported the case of a fifty-eight-year-old woman with a large mediastinal tumor that was unresponsive to irradiation. Two years after discovery of the tumor, a severe refractory . . .


This work deals with steady-state optimization of a process formed by an algae-bacteria photo-bioreactor (PBR) in an activated sludge configuration. The optimization is done by considering the tota ...


Anti-N-methyl-D-aspartate receptor (NMDAr) encephalitis is an autoimmune encephalitis that commonly presents with various neurobehavioral symptoms. Anti-NMDAr encephalitis is known to occur more commonly in young females with teratoma. In this case, we report a rare presentation of hypersexual behavior in a 21-year-old African-American male, with an incidental finding of multicystic scrotal mass, who was also diagnosed with anti-NMDAr encephalitis. The patient had no significant past psychiatric or medical history and presented for psychiatric hospitalization with severe hypersexual behavior, aggression, disorganized thoughts, and fluctuating confusion as characterized by forgetfulness, disorientation, and distractibility, with poor response to various psychiatric medications. His laboratory tests and imaging studies were unremarkable. Cerebrospinal fluid analysis showed anti-NMDAr antibodies. Prompt treatment with intravenous immunoglobulin and methylprednisolone significantly improved the symptoms. This case illustrates that clinicians should be aware that nonspecific symptom such as hypersexual behavior may also be a predominant presenting symptom in anti-NMDAr encephalitis.


Due to the limited range of todays electric vehicles, it is important to lower the energy consumption for these vehicles. This can for example be achieved by employing an energy management system. Most research in this field focuses on strategies for individual components and only some literature exists on holistic energy management concepts. This paper presents an optimization-based holistic energy management system. The strategy is currently developed within a simulation environment and will, in the future, be adapted to a usage in existing vehicles. To demonstrate the feasibility of the concept, a hybrid genetic algorithm is implemented. By adjusting the velocity for each spatial discretization step and the air conditioning unit's power for each time step of a driving cycle, the total energy consumption, traveling time, and cabin temperature are optimized. The results show that the energy consumption can be considerably reduced, while keeping the driver comfort well within acceptable limits and the driving time constant.