The Sears Roebuck and Co. has decided to close its store in South Bend at 411 S. Lafayette because of "poor experiences" and to open a new one at University Park Mall in Mishawaka, according to the South Bend Tribune yesterday. The Marchmont Kovas story in yesterday's edition of the Tribune reported that South Bend Mayor Peter J. Nemeth had been called by Arthur M. Wood, Sears chairman of the board, late Monday. Nemeth quoted Wood as saying that Sears has had poor experiences in downtown locations in other cities and does not want to take that risk with a new store in South Bend. B. L. Wade, manager of the South Bend Store, announced in a press conference on Monday afternoon that the company will open the new store in 1979 at the mall located at Grape and Ind. 23. The area was recently annexed by Mishawaka. Wade also indicated that the present store building, which is owned by Sears, will eventually be sold, and ground will be broken for the new store in about six months. It will take about a year to construct the new two-story building. "After the most thorough consideration and review of the proposal for the downtown structure and location, we have concluded that the interests of our customers, as well as our employers and stockholders, will be best served by building a new store at University Park Mall," Wade said in a story by James W ensits of the Tribune.


A low power ultra-wideband (UWB) RF receiver using two N-path notch filters is presented. The receiver architecture composes of two N-path notch filter systems as a Miller feedback network around a low noise amplifier (LNA). The used differential notch switching filter structure provides filtering at the input of the RF front-end, in addition to even-order harmonic suppression. Moreover, the differential N-path notch filter downconverts the RF signal to the baseband (BB) by using a set of $G_{m}$ cell stages. The RF receiver can operate in the frequency range of 3.1-4.8 GHz and is implemented in a 65nm CMOS process. The simulation results show that the receiver achieves a noise figure (NF) of less than 5.5 dB, a conversion gain of 61 dB over the band of interest while consuming less than 12 mW from a 1-V supply, including the local oscillator (LO) current.


Abstract : Adler tube type devices are considered. Fast cyclotron waves at one or several discrete frequencies are excited on the electron beam by the use of a Cuccia coupler. The modulated beam is shot through a 2n-pole where, contrary to the usual pumping procedure, power is extracted from the cyclotron waves. An analysis of the frequency and power conversion properties of a cyclotron wave excited 2n-pole is carried out. An experiment was made where an electron beam, carrying fast cyclotron waves of frequencies, was shot through a quadrupole. Finally an Adler tube with two quadrupoles between the input and output Cuccia couplers is considered. One of the quadrupoles extracts a fraction of the signal power at twice the signal frequency and serves as the source of the pump voltage which is fed to the other quadrupole via an external amplifier. Thus the pump voltage is phase locked to the signal. The properties of the basic types of this amplifier are discussed. (Author)


Progress in network technologies and protocols is paving the road towards flexible optical transport networks, in which dynamic leasable circuits could be set up and released on a short-term basis according to customers' requirements. Recently, new solutions for automatized network management promise to allow customers to specify the terms of the service level agreement (SLA) to be guaranteed (with different price range) by the service provider. In this paper we consider that these service level specifications (SLS), since they are now made available on-demand during the connection request, could be exploited to retrieve useful information able to improve the routing efficiency. In particular, we propose to exploit the knowledge of connection holding time, among the other SLS, to develop a novel intelligent approach for shared-segment protection (SSP). We will exploit the knowledge of the holding-time of connection requests to minimize resource overbuild due to backup capacity and hence to achieve resource-usage efficiency. For a typical US nationwide network, we compare our two proposed holding-time aware approaches to the respective two holding-time-unaware approaches: both of them, even in their holding-time unaware version, have been shown to be very efficient solutions for shared-segment protection. Nonetheless, we have obtained additional savings on resource overbuild of up to 11% for practical scenarios exploiting holding-time knowledge. 2008 Published by Elsevier B.V.


Parliament meets for the Monsoon Session between August 01 and September 08, 2011. There will be a total of 26 sittings. The agenda for government Bills includes 35 pending Bills for consideration and passing. Two new Bills are listed for introduction, consideration and passing to replace the ordinances. The government plans to introduce 32 new Bills. URL:[http://www.prsindia.org/administrator/uploads/general/1311942858_Parliament%20Session%20Alert%20-%20Monsoon%202011.pdf]


The exposition of this article establishes a series of objectives and purposes to be fulfilled in the execution of each of the procedures that have been established throughout the investigation, especially in identifying the analysis of the impact that the incessant violence in the country because of the internal armed conflict, specifically in women who have been victims of different situations that are reprehensible and reprehensible from any point of view where it is possible to directly determine the violation of the rights of women enshrined in both legal precepts of a nature international as national. Additionally it should be noted that one of the situations evidenced in the study corresponds to the scope of this, adding that only a bibliographic review is made where the impact that has been generated by the conflict on women in Colombian society can be found, compared to this, the methodology used corresponds to the search for studies and research that provide this type of information. Then it is determined that the evidenced results are regrettable and worrisome because of the consequences that have been identified in the women, being the case the creation of different organizations in search of the recognition of their rights. Finalizing it is concluded that this situation affected and continues to create consequences for society that in some cases are very difficult to repair according to the high level of damages that were generated.


Abstract This article introduces this special issue of The Journal of Strategic Studies by discussing the British model of counter-insurgency. General (later Field Marshal) Sir Gerald Templer associated the phrase 'hearts and minds' with Britain's apparently successful counter-insurgency campaign in Malaya (1948–60). The phrase 'hearts and minds' is generally associated with a less coercive approach to counter-insurgency which emphasises the importance of using 'minimum force' in order to win the 'hearts and minds' of the people. This article argues that the phrase 'hearts and minds' does not accurately describe Britain's highly coercive campaign in Malaya. The British approach in Malaya did involve high levels of force, was not fought within the law and led to abuses of human rights. Britain's counter-insurgency campaign in Northern Ireland did not deploy the same levels of coercion that were used in Malaya but, nevertheless, considerable levels of coercion were used which did not succeed in winning the 'hearts and minds' of the local people. The various interpretations of 'hearts and minds' leads to confusion about what degree of consent should be expected from the people and the implication of this for the use of force. While the term 'hearts and minds' does not accurately represent Britain's experience of counter-insurgency in the retreat from Empire; in the post-Cold War period the British military has been generally more 'political' and less coercive in its approach to counter-insurgency in Afghanistan and Iraq than the more conventional US approach to counter-insurgency. The British approach to counter-insurgency has influenced the recent development of US counter-insurgency doctrine but there are still considerable differences in the British and US approach to counter-insurgency which has led to severe tensions in the relationship between these allies. The 'hearts and minds' description of the British approach to counter-insurgency may be useful in public relations terms but it undermines the theory as a guide to operations because it can be interpreted in such divergent ways. The future may be to more carefully and practically specify in what contexts and circumstances the deployment of force is legitimate.


Objective To understand the prevalence of hypertension in rural residents of Chongqing, and thus provide the advise for controlling the hypertension and comprehensive prevention of chronic disease. Methods Data of chronic diseases (e.g. hypertension) in the farmers of Chongqing were collected through questionnaire survey and physical examination. Results 1 528 subjects were examined. The percentage of subjects with hypertension was 39.6% (male, 38.9% ; female, 40.1%), and the average age was 51.3±13.9. 95.5% of the subjects had the education background of junior middle school or below. 85.4% of the subjects were married or cohabiting. Over 50% of the respondents like to eat pickle and kimchi. 83% of the respondents consumed fresh fruit less than 7 times a week. The percentage of respondents having the high and medium strength of recreational activities was 2.6% and 6.7%, respectively. Age, marital status, the status of hypertension of their parents, and body mass index level are the independent factors of hypertension. Conclusion Residents living in the rural areas of Chongqing are at a higher risk of having hypertension. Living style and the prevention measure should be improved. Reducing exposure to the risk factors and the promotion of health education may reduce the incidence of hypertension.


In a long human teaching practice,people focus on cognitive factors in the process of teaching while emotional factors aren't enough to understand.Blurry understanding to emotional functions has become a crucial factor for restricting classroom administration research and improving teaching quality and teaching efficiency.With the investigation and analysis,the objectiveness and the causes of emotional factors existing in the process of physical teaching are analyzed,and the functions of emotional factors in the physical teaching are discussed.


The effect of the Yield (Y) to Tensile (T) ratio, Y/T, on the structural reliability of linepipes with longitudinal defects was studied in this work. A model based on elastic-plastic fracture mechanics (EPFM) and plasticity theory, was developed for that purpose. The analysis allows for load or deformation control situations. The results are shown in terms of curves of critical defect size vs. the controlling variable, i.e. load or deformation. For each one of the several materials studied, different cases with different Y/T values were considered. Even for the lower limits of experimental data, i.e. larger Y/T, the materials have adequate defect tolerance.Copyright © 2003 by ASME


BEFORE DISCUSSING Part 2 of the course, it may be useful to see where the supplementary subjects of Part 1 stand in relation to the course as a whole, especially as they are intended to be essentially 'practical' subjects. These subjects are not intended to raise the level of Part 1, nor are they in any way entry requirements for Part 2—a student may complete the whole course satisfactorily without taking any of them. What then are they for? There are four main reasons for the supplementary subjects.


This anthology includes the title story about a dissolving marriage and an obsessive love affair that symbolizes the uneasiness and fear resulting from missile installations in North Dakota farmland.


There is an extensive body of research around ways to prevent falls in older people, however how to best engage older people with fall prevention advice is a complex health promotion issue with messages that promote health and independence probably being more effective (Yardley & Todd, 2005).One health education method adopted has been the use of peer educators and this report will outline the rationale, methods used and some issues from the development of such a project in south east metropolitan Melbourne, Australia. ''Peer education is the teaching or sharing of health information, values and behaviours by members of similar age or status'' (Sciacca, 1987, p. 4), with the history of peer educators being traced back to Aristotle (Wagner, 1982). A review of the rationale given for the use of peer educators identified that they are a cost effective, credible source of people who can be used to educate hard-to-reach groups as the messages may be more acceptably received. The process can be empowering for those involved and peer educators can act as positive role models and reinforce learning through ongoing contact (Turner & Shepherd, 1999). Peer educators were part of an effective strategy developed in the ''Stay on Your Feet'' multi strategic community-wide intervention to decrease falls in older people in the North Coast, New South Wales (Kempton et al., 2000) and their use has been replicated in many parts of Australia. In October 2006 three-year funding was successfully obtained from the Victorian State Government for a ''Whole of Community phase 3'' fall prevention project. The application was from an alliance between two primary care partnerships (service providers from local government areas who join in partnership to improve delivery of primary care services) in south east metropolitan Melbourne. A formal project steering group was established that included a physiotherapist, occupational therapist, health promotion coordinators, representatives from participating local councils plus a peer educator. A fall prevention project worker was employed to be responsible for the day-to-day running of the project. The main thrust of the project was to develop a fall prevention peer education project. A manual had been already developed by a multidisciplinary team that included an occupational therapist and health promotion coordinator and subsequently three peer educators had already been trained. The peer educator base was expanded by recruiting ten more volunteers aged over 50 and this was done by approach to known volunteers or, in one


Velocity-map imaging has been employed to study the photoemission in Ne and N4,5OO Auger decay in Xe induced by an isolated 85 eV extreme ultraviolet (XUV) pulse in the presence of a strong few-cycle near-infrared (NIR) laser field. Full three-dimensional momentum information about the released electrons was obtained. The NIR and XUV pulse parameters were extracted from the measured Ne streaking traces using a FROG CRAB retrieval algorithm. The attosecond measurements of the Auger decay in Xe show pronounced broadening of the Auger lines corresponding to the formation of sidebands. The temporal evolution of the sideband signals and their asymmetry along the laser polarization axis exhibit oscillations similar to those known from attosecond streaking measurements. The experimental results are in good agreement with model calculations based on an analytical solution of the Schrödinger equation within the strong field approximation.


The most important goal of the business is to make a profit. It is expected that in the businesses, the production factors will be used effectively and the profit target will be achieved. Profit is also the most important indicator in agricultural production enterprises. To achieve this goal, profit planning is required. One of the most appropriate methods used in profit planning is break even point analysis. With the help of break even point analysis, important information is obtained about the level of production at which the enterprise passes to profit, how the changes in production affect the profits and the amount of production required to achieve a certain profit target. In this study, fifteen of the agricultural products produced in Kahta district of Adiyaman were subjected to break even point analysis in order to determine the level of transition to profit. The statistical data of Kahta District Directorate of Agriculture and Forestry in 2018 were used in this study. Break-even point was calculated for each product by analyzing the data. According to the results of the analysis, the products that reached the highest yield / break-even point ratio were onion, melon and tomato. Keywords: Break even point analysis, agricultural production, cost, Kahta DOI : 10.7176/JESD/10-16-10 Publication date : August 31 st 2019


Council has a library of tourism photographs which we can provide to operators within the Shire to assist them to promote their businesses.


Taboos are products of wushu which can avoid something unexpected.taboos can be found in all the field of life in the pre-qin dynasty.The reason of taboos are of variety.but their aim are the same:to forbid or restrict people's behaviour and thoughts.It is not the legal system,nor is it moral norms.But to some extent,they are a kind of special and spontaneous restriction to collectivity and individuals,and their influence people through faith and belief are very stronger than we noticed.


We summarize here the main ideas and results of our papers [28], [14], as presented at the 2013 CIRM Meeting on Discrete curvature and we augment these by bringing up an application of one of our main results, namely to solving a problem regarding cube complexes.


This article introduces the main ideas behind prefixes equivalence classes, a process that allows essential information distributed through millions of Internet BGP updates to be captured in a few dozen data records. The technique was successfully used in the past as a means to tackle the problem of optimizing iBGP overlays for a real-world application case, a South American Internet Service Provider (ISP), by then in the early stages of the deployment of its international infrastructure. Recent experimental results performed over a larger network that could potentially lead to millions of classes show that prefixes classes technique preserves its remarkable behavior. In addition, there is evidence that such performance is a consequence of the intrinsic structure of the Internet and such results could be replicated to other regional ISPs.


Mercury toxicity is believed to be a widespread environmental dilemma that has been creating tremendous damages not only to humans, but also to wildlife. Owing to its sensitivity to mercury toxicity, F. cancrivora was subjected for the determination of total mercury (THg). The food intake of frogs is claimed to influence mercury concentration on its body, thus its stomach content was also subjected for analysis. The analysis on the gut contents of F. cancrivora revealed ten (10) food items in which the insect parts got the highest percentage of occurrence (74.19%). In addition, the total mercury concentration found on the gut of F. cancrivora is below the detection limit of <0.02 ug/g which passed USEPA standard of 0.50 ug/g implying that the detected mercury level is still acceptable. This study would like to recommend control and prevention of mercury contamination in the mining area. ABSTRACT


Field experiment was conducted at Cashew Research Station of All India Coordinated Research Project on Cashew (ICAR) under OUAT, Bhubaneswar, Odisha to study the performance of different cashew selections for nut yield by adopting RBD replicated thrice having four plants per treatment. The treatments consisted of 11 entries viz BH 6 (Jagannatha), BH 85 (Balabhardra), H 1597 (Amrutha), H 662, H 675, H 32/4, K 22-1, H 11, H 14 and Goa 11/6 (Bhaskara) including BPP 8 as local check. The clonal planting material was planted at a spacing of 7.5 x 7.5 m during 2003 by uniformly adopting recommended package of practices to raise a good crop. The results revealed significant variations among the entries for various vegetative parameters, nut yield and yield attributing parameters. The results of present study on vegetative growth parameters revealed that the cashew selections K 22-1 and H 675 were identified as dwarf in growth habit hence were proved suitable for high density planting system in cashew. The overall results revealed significant superiority of BH 85, H 32/4, Goa 11/6 and BPP 8 for majority of nut yield attributing parameters such as flowering duration (85 to 104 days), number of panicles/m2 (17.63 to 22.05), male-bisexual flower ratio (0.21 to 0.36), mean number of nuts/m2 (27.91 to 42.59) and number of nuts/panicle (5.00 to 6.00) than rest of the cashew selections. Similarly significantly better performance of selections BH 6, BH 85, H 1597and Goa 11/6 including BPP 8 as check was observed for mean nut weight (7.17 to 8.60 g), shelling  percentage (28.17 to 31.33) and annual yield (6.06 to 7.97 kg/ha) as compared to other selections. It was concluded that the cashew selections BH 85 (Balabhardra), BH 6 (Jagannath), BPP 8, Goa 11/6 (Bhaskara) and H 1597 (Amruta) may be recommended not only for better growth but also for nut yield in a sustainable manner.


We consider the problem of automatically inferring properties of programs. Our approach is to explore the application of familiar type inference principles to a \type system" suuciently expressive that the typing problem is eeectively the checking of program speciications. We use familiar syntax-directed type inference rules to give a polynomial-time procedure for inferring type theorems in this rich type system. We discuss examples of simple functional programs and the speciication information this procedure automatically infers. The enriched notion of type allows the deenition of any recursively enumerable set as a type, and includes argument-dependent output types for functions. The inference procedure is capable for example of automatically inferring that an insertion sort program always returns a sorted permutation of its input.


To elucidate the role of genetic factors in arsenic metabolism, we investigated associations of 17 single nucleotide polymorphisms (SNPs) in arsenic (+3 oxidation state) methyltransferase (AS3MT) with urinary arsenic profile in a Vietnamese population. The homozygotes for SNPs 4602GG, 35991AA, and 37853AA, which showed strong linkage disequilibrium (LD), had lower percentage (%) of dimethylarsinic acid (DMA) in the urine. SNPs 4740 and 12590 had strong LD and were associated with urinary %DMA. Although SNPs 3963, 6144, 12390, 14215, 35587, and 37950 comprised LD cluster, only homozygotes in SNPs 12390GG and 35587TT exhibited lower ratios of DMA/monomethylarsonic acid (MMA) in the urine, implying that these SNPs might be related to the low methylation capacity from MMA to DMA. The LD group including SNPs 5913, 9749, and 27215 was correlated with %MMA. SNP 8979AA showed low %DMA compared with other genotypes. The heterozygote for SNP 14458TC had a higher MMA/inorganic arsenic (IA) ratio in the urine than the TT homozygote, indicating that the heterozygote may have the stronger methylation ability of IA. The present study suggests that these SNPs are associated with arsenic metabolism in this Vietnamese population.


In this paper,the government function in the construction of innovative city was taken as the research object.And it was purposed that the government should play roles of decision maker,guide,server,coordinator in the course of construction.At last,Changzhou was taken as a case to put forward construction work direction in the course construction of innovative city.


An adequate understanding of specialized terminology is a prerequisite for the mastery of core concepts across all scientific disciplines, including psychological science. In a previous article in this journal (Lilienfeld, Sauvigne, Lynn, Cautin, Latzman, & Waldman, 2015), we presented an annotated list of 50 widely used psychological terms that should generally be avoided, or at best used judiciously and with qualifications in select cases. Herein, we offer a "sequel" by presenting a list of 50 term pairs in psychology and allied fields (e.g., psychiatry, cultural anthropology, statistics) that are commonly confused in academic writing, popular writing, or both. We draw these terms from multiple domains of psychology, including Sensation, Perception, Learning, and Memory; Social and Cultural Bases of Behavior; Personality Psychology; Psychopathology; and Research Methodology and Statistics. Many of these terms are frequently confused not merely by beginning psychology students, but also by advanced psychology students, psychology instructors, and science journalists. Our list of commonly confused psychological term pairs should hopefully be a modest contribution toward enhancing psychological literacy as well as critical thinking in psychology more broadly.


This paper explores different understandings of the interaction of private international law with the law of trusts, and particularly, the question whether a settlor should have complete freedom to choose the law governing her trust. If such freedom is granted, the settlor may not care whether or to what extent her own legal system has a trust; she merely chooses one that does, and in particular she may choose the one that offers the features that best suit her particular wishes. In some Continental countries, this is indeed possible due to the ways in which they have brought into force the Hague Trusts Convention. The author examines a range of approaches to settlor autonomy, and concludes by suggesting that full settlor autonomy as to the governing law is not necessarily appropriate in relation to trusts. A trust has a whole range of third-party effects, and so the arguments that justify party autonomy in relation to the choice of governing law for contracts do not clearly apply to trusts. This paper is one of 22 chapters in a forthcoming collection that examines a range of issues surrounding trusts in civilian and mixed legal systems.


A flow injection thermal microbiosensor was designed for the simultaneous determination of multiple analytes. The biosensor consisted of five thin-film thermistors which were located along a single microchannel. The device was fabricated on a quartz chip by micromachining. The feasibility of employing this system for the detection of two independent enzyme reactions was demonstrated using two different pairs of enzymes, urease–penicillinase and urease–glucose oxidase. The enzymes were immobilized on agarose beads, which were then sequentially packed into distinct regions of the microchannel. Using this method, samples containing urea mixed with penicillin V or with glucose were simultaneously analysed. Linear ranges of up to 20 mmol l–1 urea, 40 mmol l–1 penicillin V and 8 mmol l–1 glucose (saturated with O2) were obtained using a flow rate of 30 µl min–1 and a sample volume of 20 µl. The relative standard deviations for urea and penicillin V assays were 1.13 and 2.42% for the first 100 samples and 1.17 and 2.78% for 200 samples, respectively. The sensor is capable of analysing 25 samples per hour.


THE EMERGENCY DEPARTMENT therapy for atrial fibrillation and in particular atrial fibrillation with concurrent congestive heart failure has undergone substantial change in the past few years. It is one of the most common arrhythmias emergency physicians encounter. Atrial fibrillation results in a chaotic and ineffectual contraction of the atrium that in turn produces irregular and frequently rapid ventricular contraction. Rapid, irregular ventricular contraction reduces effective diastolic filling and cardiac output. Atrial fibrillation and congestive heart failure often coexist, and one disorder can precipitate the other. Left atrial dilatation associated with congestive heart failure can result in atrial fibrillation. In patients with controlled heart failure, the onset of atrial fibrillation can reduce diastolic filling sufficiently to tip the patient into moderate or severe failure. The combination of rapid atrial fibrillation and congestive heart failure presents a management challenge. Regardless of the cause of the fibrillation, the emer-


Foreword K.Srinath Reddy Introduction I: HEALTH SYSTEM FOR MATERNAL AND NEWBORN CARE (ACCESS QUALITY AVAILABILITY AFFORDABILITY) Access to Healthcare Services in Remote Areas Ships of Hope: Mobile Boat Clinics in the Riverine Areas of Assam (C-NES) - Radhika Arora The Three-tier Outreach Model for Hard to Reach Areas: The Sunderbans - Sourav Neogi Behaviour Change Communications Innovation in Behaviour Change Communication: The RACHNA Project - Raj Mohan Panda and Sourav Neogi Financial Access to Health Care Services Increasing Financial and Physical Access for Service Delivery: Sambhav Voucher Scheme - Sourav Neogi Health Care Infrastructure LifeSpring Hospital Pvt Ltd. - Madhavi Misra Merrygold Health Network - Madhavi Misra Human Resources Addressing Issues of Human Resources and Quality of Care: The Yashoda - Radhika Arora Quality Initiatives in Health Care Services Quality Assurance Programmes (QAPs) in Public Health Facilities - Sanghita Bhattacharya and Radhika Arora Referral Transport Emergency Referral Transport: The GVK-EMRI Model - Raj Mohan Panda and Sourav Neogi Low-cost Referral Transport: The Janani Express - Sourav Neogi II: ADDRESSING DIRECT CAUSES OF MORTALITY Newborn Care (Hypothermia) Warmth for newborns: The Embrace Infant Warmer - Madhavi Misra Post-partum Hemorrhage (PPH) Use of Non-pneumatic Anti-shock Garment (NASG): The Raksha Project - Madhavi Misra III: ADDDRESSING INDIRECT CAUSES OF MATERNAL AND NEWBORN MORTALITY Family Planning Promoting Change in Reproductive Behaviour: PRACHAR - Sanghita Bhattacharya and Radhika Arora Community-based Intersectoral Interventions in Health The Silver Lining: Community-led Initiatives for Child Survival (CLICS) - Radhika Arora Community for Care: Comprehensive Rural Healthcare Projects (CRHP) - Radhika Arora Youth Reproductive and Sexual Health Growing up Healthy: Anwesha Clinics, Friends Clinic, and Safdarjung Hospital Adolescent Health Network (SHAHN) - Radhika Arora IV: ACCOUNTABILITY OF PROGRAMMES Monitoring and Evaluation Collection of Evidence through Randomized Control Trial Setting: Ekjut Trial - Sutapa B Neogi and Sourav Neogi Putting Evident into Action: Maternal Death Audit/Review - Sutapa B Neogi and Sourav Neogi Social Accountability Initiatives Promoting Social Accountability for Safe Motherhood: White Ribbon Alliance India - Raj Mohan Panda and Sourav Neogi V: SUCCESSFUL ORGANIZATIONS AS INNOVATION ENGINES State Feature Innovative Approaches in Maternal and Newborn Care: Tamil Nadu Health System - Sourav Neogi and Madhavi Misra Organization Feature Using Science and Technology for Care: Action Research and Training for Health (ARTH) - Madhavi Misra Index


In this paper, we proposed a new method which is used in B2B search results ranking. We could implement personalized search results ranking based on the user transaction records. We using user transaction records to build trading directed graph, building transfer matrix based on trading directed graph, and calculating the credibility of users by using the thought of Pagerank~1. We could get preliminary search results according to the keywords matching,And we ranking the results one the basis of the credibility of users and the user's preference. In addition we add Feedback coefficient and the correction coefficient into transfer matrix, which could effectively prevent the behavior that doing malicious trades to get high credibility.


Multidrug resistance proteins (MRP2, ABCC2) may play a role in drug resistance in epilepsy by limiting gastrointestinal absorption and brain access of antiepileptic drugs (AEDs). We sought to investigate the effects of ABCC2 polymorphisms on plasma carbamazepine (CBZ) concentrations and pharmacoresistance in Chinese patients with epilepsy. ABCC2 rs717620, rs2273697, rs3740066 polymorphisms were genotyped by polymerase chain reaction amplification followed by restriction fragment length polymorphism analysis or direct automated DNA sequencing in 80 patients treated with CBZ monotherapy. There were no differences in CBZ maintenance doses or adjusted plasma CBZ concentrations among the ABCC2 rs717620, rs2273697 and rs3740066 genotypic groups. No associations between all the studied genotypes and haplotypes involving the three SNPs of ABCC2 and CBZ resistance were observed in this patient cohort. These results suggest that ABCC2 polymorphisms may not contribute to interindividual variabilities in CBZ daily maintenance doses, plasma concentrations, and treatment efficacy. Neurology Asia 2015; 20(3) : 221 – 227 Address correspondence to: Yingjie Guo, School of Life Sciences, Jilin University, Changchun, 130021, China. Tel: +86-431-85155316; Fax:+86-431-85155316; E-mail: email@example.com INTRODUCTION Carbamazepine (CBZ) is one of the most frequently prescribed anticonvulsant drugs for the treatment of epileptic seizures. Wide variabilities of CBZ daily maintenance doses, plasma concentrations, and treatment efficacy have been observed among patients treated with this agent. There is evidence that drug efflux transporters may play a role in drug-resistant epilepsy by limiting gastrointestinal absorption and brain access of antiepileptic drugs (AEDs). Therefore, genetic variants of drug transporter genes associated with functional variations in efflux activity may influence CBZ plasma concentration and treatment efficacy. Drug transporters are members of the membrane transport protein families belonging to either ATP-binding cassette (ABC) or solutelinked carrier super family of proteins. Among them, P-glycoprotein (P-gp), encoded by ABCB1 (or MDR1), is an extensively studied drug efflux transporter in epilepsy. Although it remains equivocal whether CBZ is a substrate of P-gp, numerous studies have explored the role of ABCB1 polymorphisms on the drug response in different ethnicities. Recently, multidrug resistance proteins (MRP2, ABCC2), have been shown to mediate CBZ transport. Increased expressions of ABCC2 have been observed in brain tissues of patients with refractory epilepsy. It was hypothesized that genetic variations in the ABCC2 gene would probably affect individual drug responses to CBZ. ABCC2 rs717620, rs2273697 and rs3740066 are the major functional genetic variants, which have been characterized for their influence on the respective mRNA, protein expression, or oral clearance of drug substrates. Choi et al. showed that the combined variation of rs1885301and rs717620 decreased ABCC2 promoter activity by 39%. Laechelt et al. demonstrated both a decrease and an increase in ABCC2 expression or activity with different haplotypic combinations of rs717620, rs2273697 and rs3740066, which is supported by functional data showing these ABCC2 polymorphims affected the clearance of Neurology Asia September 2015 222 mycophenolic acid, methotrexate or irinotecan. Recently, Puranik et al. reported that the rs2273697 variant was associated with higher CBZ clearance, and adverse neurological drug reactions to CBZ, but there are some conflicting results in other studies. These conflicting results reinforce the need to check the functional significance of ABCC2 polymorphisms in different ethnic groups. The present study was performed to evaluate associations of the rs717620, rs2273697 and rs3740066 genotypes of ABCC2 and their haplotypic combinations with CBZ plasma levels and treatment efficacy in Chinese patients with epilepsy.


INTRODUCTION
The primary objective of this study was to evaluate outcomes and prognosticators in patients who underwent radical nephrectomy (RN) or cytoreductive nephrectomy (CN), depending on the clinical stage of disease preoperatively, with a pathological T4 (pT4) renal cell carcinoma (RCC) outcome. There is little data on the outcome of this specific subset of patients.

METHODS
From 2009-2016, we identified patients in the Canadian Kidney Cancer information system (CKCis) who underwent RN or CN and were found to have pT4 RCC. Clinical, operative, and pathological variables were analyzed with univariable and multivariable Cox proportional hazard models to identify factors associated with overall survival (OS). Survival curves were created using Kaplan-Meier methods and compared using the log-rank test.

RESULTS
A total of 82 patients were included in the study cohort. Median patient age was 62 years (interquartile range [IQR] 55, 70). The majority of patients had clear-cell histology, 50 (61%), and 14 (17%) had sarcomatoid characteristics. Median followup was 12 months (IQR 3, 24). At last followup, eight (10%) patients are alive with no evidence of disease, 27 (33%) are alive with disease, four (5%) were lost to followup, 36 (44%) died of disease, and seven (8%) died of other causes. Tumor histologic subtype (clear-cell vs. non-clear-cell) (p=0.0032), larger tumor size (cm) (p=0.012), and Fuhrman grade (G4 vs. G2-G3) (p=0.045) were significantly associated with mortality in a multivariable Cox regression model.

CONCLUSIONS
For patients with pT4 RCC after RN or CN, survival is poor. Sarcomatoid features, non-clear-cell histology, and presence of systemic symptoms were associated with worse OS.


Drilling through shale layers is associated with many problems such as wellbore instability, hole wash out, pipe stuck, etc. Reactive shale with swelling potential can lead to such problems. Reactive shale is a shale that has high swelling clay mineral like montmorillonite although there was a little amount of this clay mineral. So determine the type of clay mineral in shale formation and obtain the distribution of swellable clay mineral can help us in the selection of stable well path and determination of well location that has least instability problem, prevention and prediction of problem associated with swelling clay mineral such as pipe stuck, hole wash out, bit balling, etc. In this paper, we used thorium and potassium from corrected gamma ray (CGR) log to obtain the type and percentage of clay mineral. Then used X-ray diffraction for more detail analysis of clay mineral constitute. Finally, geostatistical modelling is used to obtain the continuity of clay mineral in the reservoir and estimate the amount of desire clay mineral along the reservoir.


Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease of the nasal and paranasal sinuses that affects 12% of American adults.1 CRS with nasal polyps (CRSwNPs) is a subtype of CRS typically characterized by increased levels of interleukin (IL) 4, IL-5, and IL-13, which are the cytokines of type 2 inflammation.2,3 Since the US Food and Drug Administration's approval in 2019, dupilumab has emerged as a promising novel biologic therapy for CRSwNP, as it targets IL-4– and IL-13– mediated pathways.4,5 In phase 3 clinical trials, dupilumab demonstrated favorable sinonasal outcomes and acceptable adverse event (AE) profiles.4,6 The most commonly reported AEs include nasopharyngitis, injection site erythema, headache, and epistaxis.6 In fact, the rate of significant AEs leading to discontinuation is less than 5% in phase 3 trials, with no clear leading cause.6 A recent study based on the Federal Adverse Event Reporting System (FAERS) examined AEs in more detail and found that, of the reported AEs, dermatologic and musculoskeletal AEs represented 13.9% and 6.4%, respectively.7 Given these findings, we sought to examine real-world experiences with the use of dupilumab, with a particular focus on its safety profile. 2 METHODS


The interest in organizational culture has led to collecting and cataloging the themes in stories from many organizations. Here stories and other accounts of organizational life are interpreted on the basis of the resemblance of symbolic elements in the stories to a classic myth archetype. Taking this interpretative approach further suggest that some widely told stories can themselves be considered as myths. It is argued that even though stories can use symbolic elements from many sources, the archetypal myth themes are widely known conventions and are a plausible and rich source of highly expressive symbolism.


(Figure 1C). After perfusion fixation of the heart under the normal diastolic pressure by 10% buffered formalin for 24 h, epicardial coronary arteries were removed from the heart. The whole stent segment was embedded in plastic (Technovit 8100; Heraeus Kulzer, Wehrheim, Germany) with the stent struts. Histological sections stained by hematoxylin-eosin and Masson's trichrome showed a convex mass lesion (Figure 2A) composed of cholesterin crystals, macrophage foam cells and necrotic debris over the stent struts (Figure 2B). Although we could not confirm the endothelial cell coverage due to the technical difficulties of immunohistochemistry using the plastic embedded sections, the luminal surface of the mass was partially covered with thin and flat cells, consistent with endothelial cells. Part of the luminal surface, however, lacked the cell coverage with fibrin A 70-year-old man was hospitalized due to polymyositis and died of pneumonia 1 week after admission. Sirolimus-eluting bioresorbable polymer coated stent (Ultimaster; Terumo, Tokyo, Japan) had been implanted in the circumflex artery 2 months previously. He had been prescribed aspirin 100 mg/day and clopidogrel 75 mg/day. An autopsy was performed followed by ex vivo intravascular ultrasound (IVUS; Terumo), optical frequency domain imaging (OFDI; Terumo) and coronary angioscopy (CAS; FiberTech, Tokyo, Japan). IVUS and OFDI showed a convex-shaped mass with echo attenuation, and protruding mass with a smooth surface accompanied by high backscattering within the stent-implanted segment, respectively (Figure 1A,B; Movie S1). CAS showed a yellowish polypoid lesion over the stent struts. Red thrombus adhesion was observed at the base of the protruding mass lesion


The authors have measured the 10.8-GHz flux densities of 285 radio sources at 14 epochs between January 1979 and November 1982. For the subset of 258 objects constituting a complex flux-density-limited sample selected at 5 GHz, it is found that at least 45% vary within ten years. About nine-tenths of the steep spectrum (α ≤ -0.5) sources do not vary, whereas about two-thirds of the flat spectrum sources do. Quasars are much more likely to vary than either galaxies or empty field sources. Most objects from the S4 catalog identified with empty fields are galaxies beyond the plate limit.


The photocatalytic degradation of radiation absorbing and nonabsorbing pollutants in slurry reactors is analyzed in terms of two performance parameters: the observed photonic efficiency (OPE) and the removal efficiency (RE) [Sagawe et al. Chem. Eng. Sci. 2003, 58, 2587]. The OPE proposal permits a simple approach to analyze complex reacting systems. Conversely, to calculate the RE, the modeling of radiation absorption and scattering inside the reactors is necessary, which requires the determination of the optical properties of the catalyst and the modeling of the optical effects of the reactor walls. The degradation of dichloroacetic acid, phenol, and 4-nitrophenol was studied employing aeroxide TiO2 P25 from Evonik-Degussa in well-mixed batch reactors irradiated by UV lamps. 4-Nitrophenol has the particular characteristic to compete with titania for the absorption of photons in the employed wavelength range of irradiation. Two reaction kinetics proposals were considered to interpret experimental data: a ...


India is one of the emerging markets among the global market, then it requires appropriate administration of capital structure. The paper investigates the impact of capital structure on financial performance of listed on Bombay Stock Exchange (BSE) 100 of Indian manufacturing companies over the research period 2014-19. The study applied econometric models for panel data analysis and used pooled OLS estimation, Fixed effect, and Random effect Methodology along with the Hausman test and Ramsey RESET. This research investigated the company's performance by four accounting measures namely: Return on Equity (ROE), Return on Assets (ROA), Earnings per share (EPS) and Tobin's Q. This research explores the relationship either optimistic or pessimistic amongst capital structure and the financial performance. Employed Pearson's correlation and regression techniques, notified that there is a negative relationship amongst STDR, LTDR and ROE. Moreover, research investigated a significant negative relationship amongst capital structure variables as LTDR, TDR with the financial performance measured by ROA, EPS, and Tobin's Q. However, the results revealed that long term debts and total debts decrease the financial performance, while short term debts facilitate to increase the financial performance.


N,N-bis(2-hydroxyethyl)-2-aminoethane sulphonate(BES sodium)was synthesized by the reaction of diethanolamine with sodium 2-chloroethane sulfonate(for short:SCS).The product was characterized by means of 1H NMR,13C NMR,FT-IR,XRD,et al.Based on the change of pH values in the reaction system and NMR spectrum of product,technologcial conditions were optimized: the ratio of reactants was 1∶ 1.1,reaction temperature was 60~80℃ and reaction time was more than 60min.


Wireless sensor networks (WSNs) are the sensor nodes that are generally interconnected and these nodes communicate wirelessly to collect the data from the environment around them. Sensor nodes are low-powered and distributed in an ADHOC manner and in a decentralized mode. WSNs setup comes with some limitations such as energy constraints and the cooperative demands essential to perform multi-hop geographic routing for Internet of things (IoT) applications. Quality of Service (QoS) depends to a great extent on offering participating nodes an incentive for collaborating. The real-time applications of WSNs have potential design limitations such as energy and other QoS constraints in the context of IoT. This work basically formulates two different re-transmission strategies for optimized cross-layer design and also integrates the framework with a swarm intelligence technique assisted Bacteria Foraging Optimization (BFO) for efficient Cluster Head (CH) selection. The proposed work designs analytical modeling to realize the formulated concept and also simulates the computational design in a numerical computing tool. Finally, an extensive simulation is carried out using the MATLAB simulation tool. The obtained results show the effectiveness of the proposed system in terms of delay is reduced by 12%, throughput is increased to 10%, remaining energy of the network is increased to 11%, and packet delivery ratio of the proposed work in increased to 7-9% in comparison with the existing system.


Deep optical B band images of the ROSAT HRI error region of RX J0720.4-3125 reveal the presence of two faint stellar-like objects with B = 26.1 +/- 0.25 and B = 26.5 +/- 0.30. Exposures obtained through U, V and I filters are not sensitive enough to detect the two candidates and provide upper limits of U = 24.9, V = 23.2 and I = 21.9. These new observations virtually establish that RX J0720.4-3125 is a slowly rotating, probably completely isolated neutron star. The absence of an optical counterpart brighter than B = 26.1 seems incompatible with a neutron star atmosphere having a chemical composition dominated by Hydrogen or Helium. UBI photometry of field stars shows astonishingly little interstellar reddening in the direction of the X-ray source. Together with the small column density detected by the ROSAT PSPC, this suggests a mean particle density in the range of n = 0.1 - 0.4 cm-3. Such average densities would imply very low velocities relative to interstellar medium (Vrel < 10 km/s) if the source were powered by accretion. These stringent constraints may be relaxed if the neutron star is presently crossing a small size structure of higher density or if the effective temperature of the heated atmosphere is overestimated by the blackbody approximation. Alternatively, RX J0720.4-3125 could be a young and highly magnetized cooling neutron star.


Background and aim: Aromatherapy is the art and science of using essential oils extracted from aromatic plants, and is concerned with natural balance, coordination and promotion of health. This study was designed to determine the effect of


The aim of this study is to assess the appropriateness of a new method for comparative welfare research. The methods of clustering used so far in order to construct typologies for welfare states are well known and widely applied in the literature of comparative welfare research. Recently some new research methods have become available for comparative welfare state researchers. We approach here the classification and clustering of welfare states by means of a novel method invented and developed by Academician Teuvo Kohonen at the Helsinki University of Technology for purposes of data analysis and information visualization. This neural network algorithm can cluster cases characterized by multidimensional data on a two-dimensional output space, the SelfOrganizing Map (SOM), where the central dependencies of the data are represented on a kind of two dimensional grid, the map. The learning is carried out by iterative regressions. The neurons of the map (node) represent a model. The data input values are connected to each node of the map and the models become ordered so that similar models are moving closer to each other while dissimilar models move away from each other as the iterations proceed. Our purpose is to conduct an experiment. The Self-Organizing Map is applied to test the empirical relevance of the ideal typical Nordic welfare model. The clusters are defined completely from data and no model for clustering need be defined a priori. The results of our experiment indicate that the SOM can be used as a supplement to traditional statistical methods in cases of small-N, though the potential benefits are bigger when the sample size is large.


This biography of Princess Melikoffis presented with the dual purpose of uncovering a life story, and using that story to illustrate wider social structures and themes, which in this case include class and gender, imperial centres and peripheries, citizenship, and colonial anxiety. As the story is about an ordinary girl who becomes a princess, the biography is also positioned within a Cinderella genre, with its elements of romance, intrigue, pathos and the exotic.
Pauline Curran was born in Hobart in 1893. Her family was part of the growing Tasmanian middle class, anxious to cast off the shackles of an insalubrious heritage at the edge of the British Empire, and to strengthen claims on life at the centre. Pauline was at risk of being left 'on the shelf as well as on the edge, but she inherited considerable wealth and whilst its sources were dubious, its effect was to buy her finery, travel, and greater marriage prospects than Hobart offered. In 1925 word came to Hobart from Monte Carlo of Pauline's betrothal to Prince Maximilian Melikoff, former Captain in the Russia Imperial Army.
The thesis addresses issues involved in writing biographies of subaltern characters, who have not left rich trails, yet in whom there is public interest, and from whom much can be observed about human experience in particular epochs. It considers Tasmania's struggles in overcoming social and economic disadvantage, the trope of colonial women and their travel experiences, and the rituals of transformation that attend on women who are recreated from the ordinary to being 'special'. It examines Pauline's 'royal wedding' as an example of empire reinforcing itself as a hierarchical entity, and it reveals the fragility of women's citizenship status in the first half of the twentieth century. The thesis considers life in London between the world wars, the fate of the Russian diaspora, and the princess's motivation in establishing a trust fund to save the baby seals.
The methodology considers similarities and differences between biography and microhistory, and positions the available primary sources against secondary material that provides context. It carries the theme of transformation, and, in concluding that the Princess Melikoff story, like all wondertales, offers the possibility of enchantment to the one who opens the door, it suggests that this has particular relevance to Tasmania since the marriage of another Tasmanian woman, Mary Donaldson, to the Crown Prince of Denmark.


Background & Objective: Attention to the necessary skills in time and place are among the most important issues in the evaluation of the quality of academic education. The present study aimed to evaluate the access of students to the 21 century general skills at Tabriz University of Medical Sciences, Iran. Materials and Methods: This cross-sectional, descriptive study was conducted on 300 medical students, who were selected via simple random sampling. Data were collected using the questionnaire developed by Mahmoodi and Mola, which its validity has been confirmed based on expert opinions, and the reliability has been established at the Cronbach's alpha of 0.90. Results: The general skills of the 21 century in the medical students were at an average level in the cognitive and affective domains considering a theoretical average of 3 (P<0.0001). However, the skill level was observed to be above average and favorable in the sociocultural domain (P<0.0001). Conclusion: According to the results, the access of the students at Tabriz University of Medical Sciences to the high-level cognitive and affective skills of the 21 century was average, which should be taken into account for the optimization of the teaching-learning process and improvement of the curricula. D ow nl oa de d fr om z um s. ac .ir a t 3 :5 0 IR S T o n S at ur da y O ct ob er 1 9t h 20 19 [ D O I: 10 .2 92 52 /e dc j.1 0. 28 .9 6 ] 21st Century Gerneral Skills 94 Journal of Medical Education Development , Vol 10, No 28 Winter, 2017 Introduction Today, globalization has become a strategic issue among the international research and experimental issues (1), influencing the culture, politics, and economy of countries as a chain of transformations (2). Education is one of the most important areas affected by globalization, and researchers have proposed a wide array of theories with regards to the recognition and elucidation of the associated aspects of globalization (1). In the 21 century, the assumptions toward the world are rapidly changing (3). Simultaneous with the transformations in communities, the skills required for citizens should also change in accordance with the complexities and problems of life (4). One of the significant challenges in every community is the abilities and skills required for living in the current era; therefore, preparation of university students and graduates through developing fundamental global skills is of paramount importance (5). With the changes in the assumptions of the 21 century about the world and communities, in addition to the specialized and disciplinary knowledge, access to the basic and general skills and information regardless of the fields of academic study has been further accentuated (6-8). As the most fundamental unit for the endorsement of human resources, universities play a key role in this regard (5). In recent years, instructors, employers, and policymakers have stressed the importance of evaluation systems in order to trace the abilities of graduates in high-level thinking and problem-solving and assess their knowledge and skills in line with the global workplaces based on the technologies of the 21 century (9). Organizations such as the Guide for the 21 Century Skills, National Science Foundation, Education test service center, Metiri Group (10), as well as authors such as Frey & Fisher, Elkins, Carroll, Burmack, Riddle, and Trilling & Fidel have emphasized on the essentiality of the learning skills of the 21 century for the purpose of alignment with the transformations in this era (11). Some of the main learning skills of the 21 century, as defined by experts, are critical thinking, information technology, effective interactions, creativity and risk-taking, interpersonal skills, personal, social and civil responsibilities, high efficacy, prioritization, management and planning, flexibility, adaptability, and self-confidence (12). Investigating the necessary abilities and skills in the medical field in the 21 century, Rees D ow nl oa de d fr om z um s. ac .ir a t 3 :5 0 IR S T o n S at ur da y O ct ob er 1 9t h 20 19 [ D O I: 10 .2 92 52 /e dc j.1 0. 28 .9 6 ]


By measurement of the current on the spot off the Manju island of Shensi under the condition of the same ET and EN.Elicit hydrodynamic resistance formula of the circular cylinder cage under of water stream can be obtained as follows: F=耠R(0.83cos2瑁-0.2007h)2d鑔h+ 耠R(0.83cos2瑁-0.2007h)22d鑔h And on the condition of,ET =0.65,R=8 m,H=8 m,the result of calculation is compared with that of the mode l test. It indicated the resistance of net is 85.5 % of the gross resistance.


Sydenham's chorea is a post‐streptococcal, autoimmune, neuropsychiatric movement disorder. Sydenham's chorea is a major criterion for diagnosis of acute rheumatic fever with the implication of potential long‐term sequelae including cardiac complications. It is well established that there is psychiatric comorbidity in Sydenham's chorea, but there are variations in the literature regarding the nature and prevalence of psychiatric diagnoses associated with Sydenham's chorea. The aim of this review was to systematically evaluate the evidence for psychiatric symptoms presenting with Sydenham's chorea. Knowledge of comorbid psychiatric symptomatology will support early diagnosis and treatment, leading to improved long‐term outcomes for children with Sydenham's chorea.


According to the premature shortcoming of GA, a well designed crossover and mutation strategy are proposed and the implementation are presented in detail, and the immigrate operator is adopted to improve the performance of GA. Finally, the method was applied to the training of ANN, and a well result in short-term load forecasting is achieved.


Purpose: Researchers have provided evidence for behavioral health disparities between transgender and cisgender individuals. Few studies considered the impact of possessing sex characteristics at birth that are not congruent with gender identity. In studies that examined gender-affirming medical interventions (GAMIs) and behavioral health in transgender adults, important variables and a range of behavioral health symptoms have not been considered. This study explored relationships between three GAMIs and scores on 6 symptom measures, while controlling for key variables. We hypothesized that, compared with transgender people who desire but have not yet engaged in a GAMI, those who engaged in the GAMI will report lower symptom scores on behavioral health outcomes. Method: Using a cross-sectional design, data from 868 transgender people were analyzed through comparison of the behavioral health of those who completed a given GAMI and those who wanted to complete the intervention. Results: GAMIs were associated with lower scores on measures of depression, social anxiety, generalized anxiety, and PTSD and higher scores on alcohol abuse for trans masculine identity spectrum (TMIS) people who completed GAMIs compared with those who desired but did not complete GAMIs. Results related to trans feminine identity spectrum (TFIS) people largely demonstrated nonsignificant differences. Discussion: Results indicate that among those who desire GAMIs, the completion of GAMIs are associated with better behavioral health for TMIS people, with the exception of alcohol abuse. Nonsignificant differences in the results of TFIS people may be attributable to differences in sample size, social ramifications, GAMI satisfaction, and hormone effects.


In our classical view, inflammation is triggered by environmental changes; may it be pathogens or tissue damage. The stimuli activate a complex transcriptional program that is both cell type and stimulus specific. At the cellular level, a complex gene expression programs that include hundreds of genes is activated within minutes after the initial activation through a stimulus [1]. But this response can vary not only between cell types [2], but even within a cell population depending on their niche environment [3]. In response to inflammatory stimuli, several response pathways can be initiated, including signal transducers and activators of transcription (STAT) [4], activator protein 1 (AP-1) [5], the nuclear factor of the κ light chain enhancer of B cells (NF-κB) [6], and interferon regulatory factors (IRFs) [7]. All these triggers have distinct binding specificities and have different receptor – ligand interaction that leads to a specific transcriptional output. For example, cytokines acting primarily through the activation of STAT TFs such as IFN-γ, are in general unable to activate NF-κB and AP1, which are broadly responsive to a large panel of inflammatory stimuli (stretching from LPS and other microbial products to tumor necrosis factor [TNF]-α) [8]. Inflammation in general, is therefore essential for survival in the adult. Specifically, the blood system responds with cell proliferation, HSC self-renewal and progenitor expansion and differentiation.


This paper develops a stylized analytical model that analyses reliability management of multiple TSOs. First we analyse the possibilities for TSO cooperation on reserves dispatch and procurement, with a focus on European network codes. Then we propose a model that theoretically analyses cross-border reserve cooperation. We distinguish two degrees of cooperation: reserves exchange and reserves sharing. Our model first determines the non-cooperative TSO equilibrium i.e. the autarkic provision of reserves. Next we compare this with the socially optimal (cooperative) policy of generation reserves procurement. The paper shows why reserves sharing is economically superior to reserves exchange. Sharing allows cost arbitrage and pooling of reserve needs while reserves exchange only takes care of cost arbitrage. The benefits of reserves exchange and reserves sharing depends on cost asymmetry and correlation of reserve needs between the TSO zones.


In this paper, we propose a new algorithm for sequential non-parametric hypothesis testing based on Random Distortion Testing (RDT). The data-based approach is non-parametric in the sense that the underlying signal distributions under each hypothesis are assumed to be unknown. Our previously proposed non-truncated sequential algorithm, SeqRDT, was shown to achieve desired error probabilities under a few assumptions on the signal model. In this paper, we show that the proposed truncated sequential algorithm, T-SeqRDT, requires even fewer assumptions on the signal model, while guaranteeing the error probabilities to be below pre-specified levels and at the same time makes a decision faster compared to its optimal fixed-sample-size counterpart, BlockRDT. We derive bounds on the error probabilities and the average stopping times of the algorithm. Via numerical simulations, we compare the performance of T-SeqRDT with SeqRDT, BlockRDT, sequential probability ratio test, and composite sequential probability ratio tests. We also show the robustness of the proposed approach compared with the standard likelihood ratio based approaches.


Abstract Global Dance Meditation for Black Liberation began with Dr. Shamell Bell's dream, a clear vision of people around the world heeding a call, at the same time, to the same rhythm, in a collective resonance. It has grown into a conversation, a community, a journey, and a call to action. This Radical Embodied Dialogue was created to honor Black dance artists and their legacies. As part of the Street Dance Activism Global Dance Meditation for Black Liberation twenty-eight-day collective healing project, we invited Marlies Yearby and Dianne McIntyre to share their stories and their shared histories. The pandemic, coupled with use of technology, opened up and provided alternative methods to host a gathering and listen to their experiences that have too often been excluded from dance history texts. This resulting documentation of some of the work of these artists restores the significance of their work to American dance history.


The present invention relates to a method of manufacturing a rigid-flexible circuit board, and more particularly, to a method of manufacturing a rigid-flexible circuit board by forming a rigid portion and a flexible portion of a circuit pattern on an upper surface of a base layer made of polyimide (PI) B) preparing an interlayer adhesive sheet; c) laminating an interlayer adhesive sheet prepared by the step b) on the inner layer circuit board prepared by the step a); d) When the interlayer adhesive sheet is laminated on the inner layer circuit board by the step c), hot press is performed only on the interlayer adhesive sheet located in the rigid portion of the innerlayer circuit board so that only the rigid portion of the innerlayer circuit board has an interlayer adhesive layer E) forming an outer layer circuit board on the upper surface of the interlayer adhesive sheet bonded to the upper portion of the rigid portion of the inner layer circuit board by the step d); and f) Wherein when the outer layer circuit board is formed on the upper surface of the rigid portion of the inner layer circuit board by the step (e), a part of the interlayer adhesive sheet located in the flexible portion of the innerlayer circuit board of the interlayer adhesive sheet is peeled off and removed , The interlaminar adhesive film including the interlaminar adhesive film and the masking film is bonded between the circuit boards so that the interlaminar adhesive is not excessively flowed by the masking film even when hot pressing is performed, Resin flow is suppressed to prevent product defects and to improve process yield. The present invention also provides a method of manufacturing a rigid flexible circuit board.


Twenty five patients with sympto- matic external discoid meniscus, treated with arthro- scopic meniscectomy, were evaluated. Surgery was total in 8 patients and partial in 17. Postsurgery fol- low-up averaged 9 years (range 4-18 years). According to Ikeuchi functional evaluation, outcomes was excellent in 88% of the patients in the partial surgery group and in only 40% of those in the total surgery group. Joint wasting of the external compart- ment was not greater in the operated knee, when com- pared with the contralateral knee.


This report summarizes research on resonantly enhanced multiphoton absorption, dissociation, and ionization processes in atoms and molecules. Multiphoton processes were studied using from one to three independently tunable visible and/or UV laser beams in order to establish both the underlying physics and the high degree of selectivity of multiphoton processes. Measurements were made to probe both the formation of excited molecular states and the subsequent behavior of excited states either in the presence or in the absence of further intense laser radiation. Detection methods include laser-induced fluorescence, ion mass analysis, and electron energy analysis. Resonant multiphoton ionization processes are studied for the H/sub 2/, I, NO, NeXe, ArXe, KrXe, and Xe/sub 2/ using both mass spectrometry and photoelectron spectroscopy to analyze the products of the ionizations. In addition, two new instruments re being developed that will provide significantly enhanced resolution, collection efficiency, and versatility in both the ion mass and the electron kinetic energy detection channels.


The effect of the temperature on vibration based electrostatic energy harvester is studied. When the vibration of 190.6 Hz and 1m/s2 is applied to the vibration based electrostatic energy harvester, power densities are measured in the temperature from 30°C to 70°C. Measured power densities don't vary by the temperature change. It is proved that electrostatic energy harvester is resistant to temperature change.


ABSTRACT The effects were studied of the separate, successive, and simultaneous administration of purified preparations of human urinary FSH and LH on the qualitative progression of spermatogenesis in hypophysectomized patients. It was observed that: 1. Neither the separate nor the successive administration of FSH and LH or vice versa stimulates adequately the germinal epithelium. 2. FSH induces only morphologic repair of Sertoli cells. 3. LH has the same effect on Sertoli cells but provokes, in addition, proliferation of spermatogonial cells and development of primary spermatocytes up to pachytene stage. At the same time begins enlargement of the diameter of the tubules, reduction of hyalinosis, and differentiation of Leydig cells from precursor fibroblasts. 4. Both FSH and LH given simultaneously in a ratio equal to one induce the spermatogenic process up to spermatids, but differentiation of Leydig cells is poor. 5. Of the other FSH/LH ratios used, only that favoring LH results in full development of s...


Discourse has become a central issue and the most varied notion in the social sciences and humanities. "When talking about discourse, discourse analysts cannot make an assumption that they are engaged in the same discourse" – the keynote, reflecting the present trend. This contribution gives an overview of the main schools of discourse studies and discourse pattern in the English-, Frenchand German-speaking areas. Both the complexity and the interdisciplinary significance of the object researched have given rise to a multitude of issues and methodological reflections. The principal tasks of the article are to consider a heuristic potential of discourse, to subject the relevant discourse methods to a critical examination, to show discourse linguistics in relation to cognitive linguistics and text analysis. The article valuates the application of discourse notion in the Russian linguistic publications in the 1990-2010s, that are getting more and more fuzzy, eclectic, theoretically not referred to any epistemological or methodological background. It emphasizes methodological differences in using the notion of discourse compared to that of functional style, which has been reserved in the Russian linguistic tradition since the 1960-70s for studying linguistic issues in the process, in the extralinguistic context. With the aim of encouraging the theoretical exchange between different theoretical approaches the author underlines, that the main methods of the present discourse analysis were used in the Russian functional stylistics (V. Vinogradov, M. Kozina, A. Vassiljeva, E. Riesel) not as a term, but as its essentials.


PURPOSE: A chemical supply apparatus of a semiconductor manufacturing equipment is provided to be capable of easily checking the replacing time of reserved chemicals by using the first and second alarming part. CONSTITUTION: A chemical supply apparatus of a semiconductor manufacturing equipment is provided with a plurality of process chambers(11,12,13), the first chemical container(31) for processing, the second chemical container(33) for reserving, a weight sensor(35) for sensing the remaining chemicals of the second chemical container by using the weight of the remaining chemicals, a weight sensor controller(40) for operating the first alarming part(41) by receiving an exhaustion state signal of the reserved chemicals from the weight sensor, a plurality of valves(V1,V2) connected with the second chemical container for controlling the chemicals flowed in and out, and a refilling controller(50) for operating the second alarming part(51) when receiving the exhaustion state signal.


In order to measure antenna properties precisely at frequencies above 100 GHz, elaborate measurement techniques are required. This is especially challenging for integrated antennas, as probes require a steady, rigid measurement setup to avoid damage. This paper introduces an antenna measurement setup that allows fast and reliable 3-dimensional antenna pattern measurements in a frequency range of 60 GHz to 330 GHz. The system consists of a probe station, a vector network analyzer (VNA) and an industrial robotic arm with six axes. The robot ensures highly repeatable and accurate measurements and allows high flexibility in terms of scan geometry and resolution. Using a probe station, this setup not only supports measurements of waveguide-fed antennas, but also integrated antennas. After explaining the basic setup, measurement results are shown to demonstrate the capability of the system.


Largely inspired by western donor good governance agenda, the current African parliaments literature has overlooked the significance of new parliament buildings that have been constructed by China and tends to place a premium on appraising the performance of parliaments and parliamentarians in executing their legislative, representation, oversight and constituency support. While understanding how parliaments perform is important and necessary, it does not sufficiently address all the ways in which these parliaments are establishing themselves as sustainable political institutions. By disregarding the new parliament buildings, the literature potentially undermines prospects of a wider understanding of the development of African parliamentary institutions. This article leverages the Chinese government donated parliament buildings in Lesotho and Malawi to make a theoretical and comparative case for the utility of discussing the concept of African legislative institutionalisation through and in juxtaposition to, the parliamentary built environment. I find that although there are stylistic and operational differences, the new parliament buildings in Lesotho and Malawi have provided a bespoke parliamentary built environment, enabled the expansion of a cohort of public officials working on legislative business and facilitated the procedural activities of the institution.


Taipings has already been undertaken by Chinese scholars in Nanking. It is hoped that an index will be furnished for such a large collection. It is hoped, too, that materials about the Taipings in the local gazetteers will be carefully reproduced in a few volumes. Possibly an American scholar or institution might some day compile a score of all Western sources for the reference of Chinese scholars, since there are not many libraries even in this country that possess complete files of the British Parliamentary Papers, North China Herald, etc.


The ever-changing demands from consumers for more fuel efficient vehicles necessitates automotive manufacturers developing ever more radical proposals for engine design.
The latest trend from manufacturers is engine "downsizing"; where a smaller, more efficient, engine is pressure-charged to recoup the lost full-load performance. An effect of
downsizing is that engines now run at significant intake pressures. Additionally, implementation of simulation techniques as an integral part of the research and design process is becoming commonplace in the automotive industry. Whether or not current models can be considered reliable for combustion prediction at significantly elevated pressures, such as those experienced by downsized engines, is a main focus of the current work, predominantly assessed through how the crank-resolved in-cylinder pressure traces from prediction, compare to experiment. Experimental data was provided by four different engines: two Jaguar Land Rover multi-cylinder engines, one naturally aspirated, the other heavily downsized, and two University of Leeds bespoke research engines operating under naturally aspirated, or high pressure conditions representative of downsized engines.
It was seen that the combustion models were not able to accurately predict combustion at different pressures without adjustment of the turbulence quantities, namely
the length scale used to define the "after-burning" process. Additionally, it is known that variability of combustion limits the performance of engines significantly; a better understanding of variability which may lead to mitigation methods would result in significant efficiency gains. The magnitude of variability in the four different engines is investigated in this work as well as the current capability in predicting the variability. Once a mean cycle
was successfully matched, the variability of the engine cycles is accurately predicted for all engines and conditions by a random-number model, invoking variability on two parameters, u0 and �, with Gaussian distribution. Moreover a novel method for assessing variability is proposed and is employed in a study to assess the influence of combustion variability at different stages of combustion. The variability of the combustion event was
seen to be a strong function of the very early stages of combustion.
The propensity for autoignition is also known to increase with operating pressure and temperature. The predictive capability, of two autoignition models, was assessed
against experimental data. It was observed that a chemical kinetic based autoignition model was more able to predict autoignition over all engines, vis-´a-vis an empirically
based model. In addition, it was also seen that a variability of autoignition within the engine existed, which was independent of burning rate. Finally, "knocking" cycles were identified within the heavily supercharged, multi-cylinder research engine which defined the calibration limit of the engine. It was seen, however, that the frequency of pressure oscillations was beyond that traditionally seen for knock cycles.


ABSTRACT In 2014, the Edom Lowlands Regional Archaeology Project renewed excavations at Khirbat al-Jariya (KAJ), an Iron Age copper smelting site in Faynan, Jordan. Located roughly 3 km from the prominent smelting center Khirbat en-Nahas (KEN), KAJ was an integral component of Early Iron Age (ca. 1200–800 b.c.) copper production in Faynan, one of the largest copper ore deposits in the southern Levant. To date, the site had only been investigated by surveys and limited excavation; the 2014 excavations opened two areas (the largest extant building and a slag mound sounding) to explore the social dynamics and temporal intricacies of copper production. The excavation results, detailed site remapping, paleobotanical analysis, and new radiocarbon dates suggest KAJ more rapidly developed into a large-scale copper production center than previously believed, likely as a strategic expansion to the industry at KEN. This reinterpretation sheds new light on the development of the Iron Age industrial landscape in Faynan.


Summary The competitive abilities of two natural populations of Dactylis glomeratafrom Norway and Portugal were studied under three controlled environments, 7 °C with an 8 h photoperiod, 20 °C with a 16 h photoperiod, and 30 °C with a 16 h photoperiod. The temperature and daylength treatments affected both the growth habits and the relative competitive abilities of the populations. At 7 °C, 8 h photoperiod the Norwegian population became prostrate and was suppressed in mixed culture compared with its performance in monoculture, and an increased specific leaf area indicated competition for light. At 30 °C, 16 h photoperiod the Norwegian population was more erect than the Portuguese, and more aggressive, with a better performance in mixed culture than in monoculture. The performance of the Portuguese population was not affected significantly either by culture or by environment. At 20 °C, 16 h photoperiod, however, the Portuguese population was suppressed, while the Norwegian population performed better in mixed than in monoculture. This yield increase of the Norwegian population was greater than the decrease of the Portuguese population, and so the mixed culture yielded significantly more than the mean of its component monocultures, whereas at 7 and 30 °C the mixed culture yielded no more than the mean of its monocultures. The physiological basis of these competitive effects is discussed.


Several published papers have highlighted increased reporting of schistosomiasis in developed countries.1 2 3 Once considered a rare tropical disease, it has become an important differential diagnosis in those who have travelled in endemic areas and who have haematuria, haematospermia, or acute neurological symptoms; swimming in freshwater lakes in Africa is the principal risk factor.

Nineteen travellers returned to Christchurch, New Zealand, with schistosomiasis over three years.2 Seven of them were men who attended a sexual health clinic with changes in their ejaculate as their principal symptom. We report these cases in detail as the clustering of cases with this presenting symptom is unusual.

The median age of the seven men was 27 years. Before diagnosis all had noted changes in their …


Swallowing is characterised by a sequence of motor events in the oral, pharyngeal and oesophageal space. This sequence is controlled by a complex motor system that includes the Central Pattern Generator for Swallowing (CPGS), located in the ponto-medullary region of the brain stem. In this paper we will discuss some facts that challenge the assumption that neural control systems for iterative movements, such as swimming, walking or breathing (iterative CPGs), can serve as a model for the CPGS (iterative CPGS hypothesis). In contrast to the iterative CPGS hypothesis, we propose a processing model of motor planning and control for swallowing that is based on two fundamental principles that are not specific to swallowing: motor coordination and motor learning. Motor coordination is a combinatory planning process generating sequentially and hierarchically organised motortemporal structures or motor plans. Being free within biomechanical and functional constraints, motor coordination enables a range of more or less fixed motor-temporal relations within the pharyngeal swallowing sequence and between bolus transit and swallowing motor events, depending in part on bolus features. Automaticity of swallowing is based on motor learning, that is, improvement of motor coordination with respect to bolus transit and airway protection, long-term storage of the resulting motor-temporal patterns and activation of these structures. The CPGS is not an iterative CPG but plays the role of the motor memory for the swallowing system. The current work does not present new data but rather provides a new interpretation of data recently published by Kendall, Mendell, Logemann, Martin-Harris and others on the motortemporal structure of the pharyngeal motor sequence.


Religion creates multiple identities in diverse geographical and cultural milieu. On the lands surmounted by early warriors, Muslim met various cults and cultures. The people with these new elements did of course not easily submit themselves to the new comers and to their religion. Naturally novel identities came up with this new interconnection and interdependence. With its relation to these cultures, Islam created different identities that have common religious values as all Muslims have on the one hand, but carried distinct cultural and local traits on the other. This is one of the distinctive characteristics of Islam that has not forced people to leave all their culture behind in order to be part of Muslim identity. The following essay canvasses these multiple identities and presents an analysis of the resistance of universal elements within Islam against locals.


In many white goods applications, high-performance vector speed control is implemented in a standalone microcontroller (MCU) while user-interface and machine-control functions are implemented in a second microcontroller. This paper introduces SuperH RISC 32-bit microcontrollers from Renesas Technology that are specifically designed to combine all functions into one MCU, thereby reducing system cost and achieving product-development advantages. We begin by defining the requirements for a single-MCU system in terms of MIPS, flash/SRAM size, peripherals and pin count. Then we compare this system to a multiple-MCU solution and discuss the advantages of the single-MCU approach, such as one based on a SuperH device. An optional on-chip floating point unit (FPU) is used to increase computing speed, and an integrated set of peripherals (motor timer unit, DMA ADC and interrupt controller) reduces CPU bandwidth usage for sophisticated speed control using a vector formulation. This system gives a product engineering team additional design flexibility. A specific case is analyzed in terms of CPU bandwidth usage to illustrate these advantages.


Enriched 2-D and 3-D finite elements are formulated for analysis of solids having multi-material junction and wedge configurations that create singular stress fields due to the material and/or geometric discontinuities. The order and angular variation of the displacements associated with the singular fields are determined from a separate special finite element eigenanalysis and used in the enrichment process. The use of these numerically determined singular fields allows enriched elements to be developed for complex configurations for which analytical fields are not available. In addition to this added flexibility of application, the current formulation applies to elements that may or may not be in direct contact with the singular point. This allows multiple layers of enriched elements to be used around the singular point and traditional mesh refinement studies to be carried out in the enriched element region. Previous enriched formulations have not provided this important capability. For cases where analytical fields are available, such as cracked solids, the performance of elements developed with the current approach is shown to be equivalent to that obtained using analytically enriched elements. Mesh refinement techniques using enriched elements are described that allow accurate stress distributions and generalized stress intensity factors to be directly determined. The importance of high-order numerical integration, use of multiple layers of enriched elements, and proper choice of the size of the enriched region are demonstrated by comparison to existing solutions for solids with cracks. Application of enriched element modelling to a 2-D bi-material wedge and a 3-D stepped-thickness anisotropic composite laminate is demonstrated. © 1997 John Wiley & Sons, Ltd.


Magnesium is a raw material of great importance, which attracted increasing interest in the last years. A promising route is to recover magnesium in the form of Magnesium Hydroxide via precipitation from highly concentrated Mg2+ resources, e.g. industrial or natural brines and bitterns. Several production methods and characterization procedures have been presented in the literature reporting a broad variety of Mg(OH)2 particle sizes. In the present work, a detailed experimental investigation is aiming to shed light on the characteristics of produced Mg(OH)2 particles and their dependence upon the reacting conditions. To this purpose, two T-shaped mixers were employed to tune and control the degree of homogenization of reactants. Particles were analysed by laser static light scattering with and without an anti-agglomerant treatment based on ultrasounds and addition of a dispersant. Zeta potential measurements were also carried out to further assess Mg(OH)2 suspension stability.


China has a long history of its traditional culture. Being modest, cautious and respectful characterizes the Chinese traditional virture. The Chinese traditional culture actually performs positive or negative impact on English language learning. This paper analyzes some examples that frequently appear in the Chinese students' classes for the purpose of carrying out more "culturally\|positive transfer", and eventually achieving the best results of learning.


The detection and analysis methods for oxide film and passive film on tinplated steel sheet including the traditional chemical analysis,electrochemical analysis and modern surface analysis technologies such as X-ray photoelectron spectroscopy (XPS),Auger electron spectroscopy (AES),glow discharge spectrometry (GDS) and electronic probe micro-analysis (EPMA) were introduced.


After analysing the relationship between the market share and the return on investment, we find that the market share is the key to profits. This conclusion provides the theoretical evidence why GE' s high market share strategy can lead to success.


One mutant which produces thermostable glucoamylase was obtained through microwave mutation, the optimum temperature of the crude enzyme from the mutant was about 20℃ higher than that of primitive strain; four active components from mutant crude enzyme were detected, and three of them were thermostable. However, the primitive strain had two active components, and only one was thermostable.


Cyclic p-amino acids, homoproline, homopipecolic acid and 3-carboxy-methylmorpholine were obtained in high enantiomeric excesses by transition metal-catalyzed asymmetric hydrogenation of cyclic β-acylamino-alkenoates. These compounds were synthesized by a thio-Wittig reaction on N-protected thiolactames.


Severe acute pancreatitis (SAP) is a serious condition caused by poor control of acute pancreatitis, and the autodigestion of trypsin plays a central role in the development of disease[1,2]. SAP is dangerous and with many complications, its incidence is about 10%-20% of all acute pancreatitis, and the early mortality rate is as high as 10%-30%. Nutrition support is an important part of the SAP treatment, and the current studies have pointed out that early enteral nutrition (EEN) can promote the intestinal function recovery and enhance the body's immunity, and is advantageous to optimizing the patients' treatment outcome[3,4]. Conventional EEN mainly provides the necessary heat for patients, supplies carbohydrate, protein and fat according to a certain proportion and avoids the severe malnutrition under consumption state, but some scholars suggest increasing the contents of some specific amino acids in order to protect intestinal function and promote disease rehabilitation. Alanyl-glutamine can be decomposed into alanine and glutamine in the body, and glutamine belongs to the nonessential amino acid of human body, belongs to the essential amino acid under stress and participates in multiple processes such as maintaining intestinal function under physiological state[5-7]. In this study, alanyl-glutamine combined with early EEN was used to for the nutritional intervention of patients with SAP, and its effect on the disease recovery was explored in order to provide a reference for the selection of followup nutrition intervention methods.


Some of the latest developments in motion planning methods have addressed the merging of optimal control with sampling-based approaches, to handle the problem of optimal kinodynamic motion planning for complex robot systems in cluttered environments. These include embedding the Linear Quadratic Regulator method in an RRT* context, or solving the kinematic problem with an RRT algorithm first and then feeding the solution to an NLP solver. An alternative approach is presented here, in which NLP is embedded in an RRT* context from the start. The resulting methodological features are illustrated with numerical examples. These include problems in which differential constraints play a fundamental role.


Long noncoding RNAs (lncRNAs) have been reported to be involved in several neurological pathogenesis conditions including cerebral ischemia. In the current study, the functions of lncRNA EFNA3 on hypoxia‐injured rat adrenal pheochromocytoma (PC‐12) cells and the underlying molecular mechanism were studied. The expression of lncRNA EFNA3 was silenced by short hairpin RNA transfection, after which the cells were subjected with hypoxia. Cell viability, migration, invasion, and apoptosis were, respectively, determined by trypan blue staining, Transwell assay, annexin V‐fluorescein isothiocyanate (FITC)/propidium iodide (PI) double‐staining, and Western blot analysis. The cross regulation between lncRNA EFNA3 and miR‐101a, as well as between miR‐101a and Rho associated coiled‐coil containing protein kinase 2 (ROCK2) were detected by performing quantitative real‐time polymerase chain reaction, RNA pull‐down, RNA immunoprecipitation, luciferase activity assay, and Western blot analysis. Studies showed that lncRNA EFNA3 was highly expressed in response to hypoxia. Deletion of lncRNA EFNA3 significantly aggravated hypoxia‐induced injury in PC‐12 cells, as the impairment of cell viability, migration, and invasion, and the inducement of apoptosis. LncRNA EFNA3 worked as a sponging molecule for miR‐101a and miR‐101a suppression‐protected PC‐12 cells against hypoxia‐induced injury even when lncRNA EFNA3 was silenced. ROCK2 was a target gene of miR‐101a. ROCK2 overexpression exhibited neuroprotective activities. Besides, ROCK2 overexpression activated Wnt/β‐catenin pathway whereas it deactivated JAK/STAT pathway upon hypoxia. Our study suggests that deletion of lncRNA EFNA3 aggravates hypoxia‐induced injury in PC‐12 cells by upregulating miR‐101a, which further targets ROCK2.


Provides a natural semantics for a subset of XACML, a language for the specification of access-control policies. Presents the key algorithm of Margrave, a tool for analyzing XACML policies. Proves the soundness and completeness of the algorithm with respect to the subset of XACML.


Crud (radioactive corrosion products formed inside nuclear reactors is a major problem in commercial power-producing nuclear reactors. Although there are numerous studies of simulated (non-radioactive) crud, characteristics of crud from actual reactors are rarely studied. This study reports scanning electron microscope (SEM) studies of fragments of crud from a commercially operating boiling water reactor. Chemical analyses in the SEM indicated that the crud closest to the outer surfaces of the fuel pins in some areas had Fe:Zn ratios close to 2:1, which decreased away from the fuel pin in some of the fragments. In combination with transmission electron microsope analyses (published elsewhere), these results suggest that the innermost layer of crud in some areas may consist of franklinite (ZnFe2O4, also called zinc spinel), while outer layers in these areas may be predominantly iron oxides.


The EU is, in formal terms, a union of states founded on the values of respect for human dignity, freedom, democracy, equality, the rule of law, and respect for human rights and values. The value of the cultural diversity of European societies is thus questioned by radical voices that endeavour to disseminate discord and fragmentation between and within MS. Both policy makers and practitioners argue for a need to develop Intercultural and Democratically competent teachers who are capable of bridging the gap between the politics of belonging and the individual´s expression of belonging. The following paper analyses three international flagship competence frameworks for the development of Intercultural competence. It argues for a need in shifting the approach in teachers education ion for addressing Cultural Diversity choosing the Council of Europe RFCDC framework as the optimal choice for teacher education towards a new paradigm of intercultural and democratic competence. people's identifications and emotional attachments to various collectives and groupings; The RFCDC was developed by a multidisciplinary team of experts and provides a meta-framework on competences that can be used within educational systems in Europe. Barrett explains that the RFCDC is the result of merging two leading policy strands that guided the CoE in the protection and the promotion of human rights and democracy: the Education for Democratic Citizenship/Human Rights Education (EDC/ HRE) CoE programme and the development of interculturalism as the CoE's preferred policy approach for responding to the challenges associated with culturally diverse democratic societies. The interculturalist paradigm was conceived as an alternative to multiculturalism. Arguments in favour of interculturalism were laid out explicitly in the CoE's White Paper on Intercultural Dialogue (CoE, 2008), the contents of which were unanimously endorsed by the Committee of Ministers (Barrett, 2020). In 2012, Andorra took up the Chairmanship of the Committee of Ministers and made education the priority of its political and policy programme. To this end, it launched a process of reflection on how education may be used to create the conditions required for living peacefully together with others in culturally diverse democratic societies. In 2013 Andorra held a Chairmanship conference focusing on the role of education in promoting learners' competences for a culture of democracy and for intercultural dialogue. The conference also explored a proposal to develop a unifying comprehensive reference framework that would describe the competences required for both democratic culture and intercultural dialogue together. In its deliberations, the the of developing a common reference framework for democratic and intercultural competences that could in of democracy