Alzheimer's Disease is a neurological brain disorder that damages the cells in brain and reduce the ability of the brain from the regular activities. It is a representation of the most common form of adult-onset dementias. Earlier detection of Alzheimer's disease can be more helpful in predetermining the symptomatic conditions of patients suffering with this problem. By diagnosing the consequences of this disease, with the help of medical scan images, it would be more useful in classifying the patients whether they are suffering from this deadly disease. Machine Learning tends to be more beneficial in diagnosing diseases and implementation of this technique, to Magnetic Resonance Imaging (MRI) inputs in identification of Alzheimer's disease, resulted in faster prediction of the disease and in the contribution of the evolution of the disease. Carrying out this technique, it is possible to diagnose and predict the individual dementia of adults by screening data of Alzheimer's disease and inducing Machine Learning classifiers. This work focuses on building an evolving framework to detect Alzheimer's disease efficiently with the help of neuroimaging technologies and prediction at a very earlier stage by using the data stacked up for Alzheimer's disease patients.


This paper briefly introduces the general situation of the development of agricultural economy of Yangcheng County, sums up four utilization modes of agricultural circular economy, and from six aspects of transforming the traditional development concept, cultivating the barriers of agricultural circular economy, and formulating the development plan scientifically, etc., probes into the problem of developing the agricultural circular economy.


Microtubules (MTs) are protein filaments forming a major part of the cytoskeleton of all eukaryotic cells which directly contribute to the process of cell division by forming mitotic spindles and providing force for the segregation of chromosomes. MTs exhibit mechanoelastic properties of considerable interest in view of their functional roles in cell division and cell shape. In this work by introducing a new method, we have analytically solved equations of motion for the vibrational dynamics of an MT that is attached at its two ends. This is especially relevant for MTs during mitosis when they attach to chromosomes and centrosomes at the plus and minus ends, respectively. Our analysis applies to MTs present inside a viscous solution and when driven by an ultrasound plane wave. We have shown that with using ultrasound plane waves the resonance condition for the MT treated as a rigid rod cannot be provided, and in order to achieve resonance we should excite a single mode of the MT with a harmonic number larger than a threshold value introduced in this paper. Having a large enough amplitude for the resonant vibration effect is crucial in order to maximize the bending moment of an MT. Attaining a high quality factor for a resonance is crucial to have a better control of the energy transfer to the MT. Finally, single mode excitation not only helps to transfer the minimum amount of energy to the surrounding medium compared with multi-mode excitation but it also allows for a simultaneous high-amplitude and high-quality factor which is impossible when using plane waves.


Using a biological sample processing apparatus and the device. Biological sample processing apparatus includes N pole, S pole, and the rod-shaped magnet having a length and a width, and a plunger covering the magnet. N and S poles of the rod-shaped magnet is substantially perpendicular to the length of the rod-shaped magnet. This device may, for example, from a solution containing a biological sample, to separate the magnetic particles.


Many systems, both natural and engineered, exhibit collective adaptive behaviour. Natural examples are swarming animals and insects, and man-made examples include swarm robots and sensor networks. Indeed many systems have both human and ICT-based agents in play, distributed over some geographical region: an informatics environment as defined by Milner. Over recent years there has been increased interest in modelling these systems in order to understand their dynamic behaviour. Here we consider the subsequent issue of how to define useful performance measures for such systems, based on consideration of a simple, intuitive example.


In this case, as in Professor Aird's, there was -a previous history of operative treatment for apilonidal sinus in the sacro-coccygeal region. The clinical and histological appearances of the sinus were those of a pilonidal sinus. It is probable that the origin in this case was a dermpid cyst occurring at a point of embryological fusion. Being a hairbearing dermoid, it formed a hair-bearing sinus. It is therefore etymologically correct to define it as a pilonidal sinus. It is suggested that to the six previously recorded sites of pilonidal suppuration may be added a seventh, the suprapubic region. It is also suggested that pilonidal suppuration could occur in any place where dermoids are apt to occur-that is, at points of embryological fusion-provided that the cyst contained hair follicles in its lining membrane. It may be that the term " pilonidal sinus " is usually reserved for the sinus occurring in the sacro-coccygeal region, and that similar sinuses occurring elsewhere are not labelled as pilonidal sinuses but given names such as suppurating dermoid cysts and so have not appeared in the literature as additional sites of pilonidal suppuration.


During coronary stent deployment there is a risk of compromising side branches, which can result in chest pain. Compromised side branches can be reopened by balloon angioplasty through the side of the stent. In a consecutive series of 10 patients with side‐branch compromise and chest pain, balloon angioplasty through the side of the stent resolved the ischemia in all cases. The stented segment showed no deterioration following side‐branch angioplasty. Six‐month follow‐up angiography showed a restenosis in the branch vessel of eight patients. The stented parent vessel restenosed in four patients. Therefore, side‐branch balloon angioplasty after coronary stenting for ongoing ischemia is technically feasible and immediately effective. Restenosis of the branch occurs in most cases. Cathet. Cardiovasc. Intervent. 46:421–424, 1999. © 1999 Wiley‐Liss, Inc.


The invention provides a mixed power driving system, which comprises a first power source provided with a driving axle, a second power source provided with a driving axle, a transmission axle connected to the driving axle of the second power source and a tri-state overrunning clutch connected with the driving axle of the first power source and the driving axle of the second power source, wherein the tri-state overrunning clutch is provided with an overrunning state, a bonding state and a two-way separation state. The first power source and the second power source are connected through the tri-state overrunning clutch, and the energy coupling or the energy separation between the first power source and the second power source can be controlled. When the tri-state overrunning clutch is underthe two-way separation state, the two power sources can independently run and the interference or the blocking can not occur, thus the energy utilization rate is enhanced, and the control is convenient.


Vascular endothelial dysfunction can initiate oxidative stress during ischemia/reperfusion (I/R). Endothelial dysfunction is characterized by an increase in blood hydrogen peroxide (H2O2) and a decrease in endothelial‐derived nitric oxide (NO) bioavailability. Previous studies using Gö 6983, a broad‐spectrum protein kinase C inhibitor that can inhibit NADPH oxidase activity, has attenuated blood H2O2 levels during femoral I/R in vivo. This study examines the effects of apocynin, a direct NADPH oxidase inhibitor, on real‐time blood H2O2 levels in femoral I/R in vivo. H2O2 microsensors (100 μm) were inserted into both femoral veins in anesthetized rats. One hind limb was subjected to ischemia by clamping the femoral artery and vein for 20 minutes and allowed to reperfuse for 45 minutes, while the other hind limb served as a sham. In the control group, H2O2 was significantly increased by 1.3–2.7 μM during 45 minutes of reperfusion in the I/R vein when compared to the sham vein (n=4, P<0.05). Intravenous apocynin (13.7 mg/kg) given at the beginning of reperfusion significantly decreased blood H2O2 levels compared to the control group (n=6, P<0.05). The data suggests that apocynin attenuates oxidative stress in femoral I/R, which may be due to inhibition of leukocyte/endothelial NADPH oxidase.


OF THESIS ENGAGING MOTHERS: SELF-EFFICACY AND MOTHER/INFANT INTERACTION AMONG MOTHERS EXPERIENCING MULTIPLE LIFE STRESSORS The purpose of this project was to interview mothers of newborns who participated in early intervention services focusing on the implementation of a tool developed at the Family, Infant and Preschool Program (FIPP) in North Carolina. The intent was to examine the experience of mothers and home visitors employing the tool, which was designed to enhance the mother/infant relationship. However, a stronger focus on the relationship between mother and home visitor emerged throughout the interviews. Among some participants the relationship among practitioner and parent appeared to create a safe space to share, practice strategies and grow. Although characteristics of FIPP practices associated with the tool remained consistent among home visitors, the way in which services were implemented were unique to each home visitor and parent. Mothers participating in the project were identified as coping with numerous life stressors associated with poverty at the time of the interviews.


In the article the theoretical solution to two main questions in the sphere perception and brain is given. First, how can we explain the link between phenomena of the subjective reality (SR) and brain processes, taking into consideration that SR phenomena do not possess physical properties? Second, how can we explain their causal function? For this purpose the informational approach is used. It is shown that SR phenomena are linked with brain processes like information is linked with its carrier that is a definite neuro-dynamical system. This resulted in the task of decoding of brain codes for SR phenomena; neuroscience started to solve the task. By virtue of the information invariable character in relation to the physical properties of its carrier (the same information can de coded in different ways) information serves the reason for changes in self-organizing system. This fact defines the peculiarity of informational causativity and of psychical causativity. SR phenomena as information serve as the reason for material changes. Here the purpose of the action and its causal effect are defined by information, not by physical properties of its carrier. From such position the phenomenon of freedom is explained as a factor of self-determination in brain activity.


DURING the last few years changes have been made in x-ray film to make it increasingly selective to the longer wave lengths emitted by intensifying screens. Obviously, these changes in emulsion have contributed materially to the increase in so-called speed of film with which intensifying screens are employed. The actual speed of regular x-ray film emulsions, when used without intensifying screens, has changed but little during the past ten years. The character of regular x-ray film emulsion has also been changed, to provide increased contrast. In fact, up to two or three years ago there appeared to be a strong rivalry to see who could put the most contrast in the finished roentgenogram. However, this increased contrast in present-day radiographs is available only when regular x-ray film is used in combination with intensifying screens. It is generally recognized that radiographs made without intensifying screens show a marked increase in sharpness of detail or definition. Because of this increase in sharp...


Scope rules are presented as they appear in the language L, which is currently under development at McGill. These rules permit a programmer to specify explicitly the duration and visibility of all objects. Such specification can be used to declare variables or to create data structures which persist from one invocation of a block to the next. In addition, the data may be caused to persist from one run of the program to the next, obviating temporary files which are outside the scope and control of the programming language. The visibility of an object may also be specified to be larger than the block that contains its declaration. This facility allows the programmer to export some objects, yet keep others private. Finally, a facility for call-site visibility is presented that provides some of the expressive power of dynamic scoping and macros without their inherent type insecurity.


Abstract In a Networked Control System (NCS), the sampling period choice is crucial due largely to network resources constraints. The approximation of continuous-time controller, commonly used in related works, may not be a good option because it is sensitive to larger sampling time values. Additionally, the varying delay presented in this kind of control system depends on the sampling period choice. This work intend to perform the integration between a stability criteria for systems with varying delay and a pole placement approach.


Excerpt Notwithstanding education, publicity, and restrictive measures lead poisoning has become the chief industrial hazard. Since compounds of lead frequently contaminate drinking water, beverage...


androgen therapy which details present knowledge on the subject. It is rather surprising to find Simmons advocating the use of. air for Rubin's tests and lipiodol for hysterosalpingography wlthout any mention of the respective dangers of air embolism or foreign body granulomata. An excellent chapter by Eastman on habitual abortion gives a balanced assessment of the value of known types of therapy. It is astounding to find Everett and Kleegman both remarking on the nonoccurrence of trichomonas vaginitis in young children. Clinically it is a by no means uncommon finding if a careful search is made for the protozoon. Of great interest is the reference to the treatment of chronic cervicitis by qUick freezing with the use of special electrodes, the apparatus working on the same principle as the refrigerator. No mention Is made of the use of chemical cauterization or of the possible hormonal relationship to the retiology of cervicitis. In a discussion on miscarriage and septic abortion Lynch states that in the last trimester or at full term, If the fcetus is dead, the uterus should be emptied or well-known consequences leading to sepsis. eventuate. This is a dangerous statement which may lead the reader to empty the uterus by surgical means. In actual practice these untoward consequences occur as a rule only as a result of interference, and as long as the membranes are intact the patient Is not In any danger. There is a very good chapter by Holmes on endometriosis. Randall has presented a logical survey of adenocarcinoma of the uterus and its treatment. A comprehensive survey Is given of carcinoma of the cervix, including every known method of treatment of the local lesions and lymphatic metastases. Montgomery describes his preparation of the vagina for the Manchester-Fothergill operation, using soap solution and 1 in 1000 "Zephiran" solution. It should be pointed out, however, that "Zephiran" is incompatible therapeutically with soap and the latter should be very carefully removed before the "Zephiran" is applied. There is still some confused thinking about streptococci and their relation to infections. Lyons refers to hremolytic streptococci which aerobic cultures fail to identify. It would be wiser to differentiate between hremolytic streptococci and anaerobic streptococci. The latter can be found on anaerobic culture, but they must be searched for carefully. In the same chapter some new ideas are presented in that to "gross surgical pathology of the wound is assigned greater importance" than the older conception of choosing "chemotherapy solely on the basis of bacteriologic identity of the infecting organism". Keeger states that in tests of cure for gonococcal infections "all patients should be followed by both smears and bacteriologic cultures for at least two weeks before a cure is accepted". Surely two weeks should read twelve weeks, as few experts in venereal disease would discharge a patient in under two to three months. There is an interesting table showing the relative incidence of different bacteria in puerperal sepsis. The largest group is the unknown group, followed by a much smaller percentage of hremolytic streptococci and anaerobic streptococci. Clinically one finds that the more frequent organism is the anaerobic streptococcus, which, of course has to be searched for In anaerobic cultures. The above figures suggest inadequate laboratory investigation. The editors intended that this book should refresh the minds of those returning to practice after the war, and this object should be fully realized in a book so admirably presented.


The mitigation of business risk management in the Covid 19 pandemic is a powerful means of controlling the transmission and easing of socio-economic interactions. To avoid Covid 19 transmission, business organizations should adopt new cultural behaviors that align with proper health protocols to avoid Covid 19 transmission. This is because there are differences in the behaviors of business organizations. This research uses a qualitative approach with a literature study. It focuses on business and management mitigation risk factors in Covid 19 pandemic, as well as their impact on its transmission. The results show that the Covid 19 pandemic risk impacts private businesses as well as the state as a public organization entity equally responsible for solving the problem. Furthermore, no business is ready with adequate risk management planning for Covid 19 transmission. This has an impact on the risk of uncertainty for business sustainability. Moreover, there needs to be a proper theoretical, conceptual, and empirical risk management mitigation of Covid 19 transmission. Consequently, this enhances the control of transmission in office and business place clusters.


To analyze, observe and survey the expired circular mould, the abrasive wearing is its main expiration form. Inspects the friction attrition behavior of alfalfa grass powder to circular mould material 3Cr13 on the abrasive wearing testing machine, with the talysurf to survey the test specimen volume loss , and conducts the observation research using the scanning electron microscope to friction surface appearance of the test specimen. The result indicated under the soft grinding compound attrition, the 3Cr13 attrition surface appearance presents the plastic deformation attrition characteristic, and is accompanied by certain degree of the microscopic cutting, therefore, under certain degree of hardness, enhances 3Cr13 the superficial toughness is the effective method of enhancing the circular mould service life.


A column experiment simulating bank filtration was conducted to evaluate characteristics of contaminant sorption and migration through a dune area of Nakdong river. Also a mathematical model based on the advective-dispersive transport equation, coupled with a linear sorption isotherm model, was developed to delineate results of column tests. Temporal and spatial distributions of phenol and trichloroethylene (TCE) were plotted as breakthrough curves (BTCs). BTC of TCE revealed more retardation in the column up to 3 pore volumes compared to the conservative substance. i.e., chloride ion. This phenomena was attributed to the higher affinity of TCE to the solid surface. Partitioning coefficients of TCE and phenol were obtained from the curve fitting and their values are 1.1 and 0.35. respectively These values are lower than obtained from sorption isotherm test as 1.76 and 1.34, respectively. It is considered that values resulted from the column experiment are able to provide more realistitic results in predicting the contaminant fate and transport in bank filtration. Simulation results revealed that as Peclet number varies from 100 to 10, in other words, reducing pumping rate, relative concentration of TCE was lowed upto 58%. Therefore, it is concluded that bank filtration system may be able to be applicable as a substitute for a water intake system.


The appearance of delaminations caused by excessive vibratory and fatigue loads in composite rotorcraft flexbeams can lead to degradation in flapwise and lagwise performance of the rotor blade. In addition, delaminations in composite rotorcraft flexbeams under cyclic loading can result in rapid fatigue failure of these elements leading to catastrophic results. A novel detection strategy is evaluated which attempts to use the scattering of structural waves generated from piezoelectric actuators to locate damage in the form of a delamination. Previous approaches to damage detection have focused on using the modal response of the structure. The approach reported in this work relies primarily on more accurate local continuum mechanics descriptions of the structural dynamics. The method developed here exploits the wave propagation solution of uncoupled equations of motion for thin composite flexbeams under rotation. Local models of structural damage in the form of chordwise interply delaminations are developed by accounting for how waves scatter at structural discontinuities. The scattering matrix, which characterizes how incoming and outgoing waves scatter at a structural defect, is used as a performance metric to quantify damage. Finally, experimental validation of the structural damage modeling and damage identification strategy were carried out on [0/90]s graphite epoxy (Gr/Ep) beams in vacuum under rotation. Chordwise midplane delaminations in the form of a teflon layer were inserted into several test specimen to simulate local structural damage in a rotorcraft flexbeam.


The strain, surface and interfacial energies of III–V ternary systems were calculated for three kinds of structure modes: the Frank-van der Merwe (FM) mode, the Stranski-Krastanov (SK) mode and the Volmer-Weber (VW) mode. The free energy for each mode was estimated as functions of the thickness and composition or lattice misfit. Through comparison of the free energy of each mode, it was found that the thickness-composition phase diagrams of III–V ternary systems can be determined only by considering the balance of the free energy and three kinds of structure modes appear in the phase diagrams. The SK mode appears only when the lattice misfit is large and/or the lattice layer is thick. The VW mode appears when the lattice misfit is large and the lattice layer is thin and only in the InPSb/InP and GaPSb/GaP systems which have the largest lattice misfit of III–V ternary systems. The stable region of the SK mode in the GaPSb/GaP and InPSb/InP phase diagrams is largest of all because the composition dependence of the strain energy of these systems is stronger than that of the other systems. The critical number of lattice layers below which two-dimensional (2D) layers precede the three-dimensional (3D) nucleation in the SK mode at x=1.0 depends on the lattice misfit. In the InPSb/InP system, the smallest number of 2D layers precede the 3D nucleation in the SK mode.


This paper details the overview of the overseas listed private enterprises in Zhejiang Province,analyzes the internal and external reasons and the cost of the overseas stock-listing,then it raises some proposes such as confirming enterprises' development strategy,promoting their own quality,considering the current trade situation and the development trend,and choosing the suitable listing place and listing way,etc.


Objective: This study aimed to evaluate the incidence of apoptosis in vitrified and nonvitrified human ovarian tissue by the use of morphological analysis and apoptosis assay techniques. Methods: We obtained human ovarian tissue biopsies from 30 women who underwent elective caesarean sections. Tissues were transported to the laboratory in pre-warmed, equilibrated Leibovitz L-15 medium within 2 hours. The tissues were cut into small pieces and divided into two groups, vitrified and non-vitrified (control). Apoptosis incidence was assessed by light microscope and the TUNEL assay and DNA laddering. Evaluation of caspase 3/7 protein levels was performed by the luminescent assay. Results: We observed no morphological signs of apoptosis in the vitrified samples. There were no apoptosis signals as evidenced by TUNEL staining and no DNA laddering pattern observed in the vitrified group. Caspase 3/7 activity was 2294±169.19 RLU/µg protein in the non-vitrified control group and 2231±89.271 RLU/µg protein in the vitrified group, which was not significantly different. Conclusion: The structure of human vitrified ovarian tissue was well preserved. Vitrification could not increase apoptosis and caspase 3/7 activity in human ovarian tissue.


- method and transmission device with large data rate between a plurality of acquisition devices (Ai) and a central station to which they are connected by a common transmission channel (V1) for the orders and a channel great speed transmission (V2) for the data. - A first clock signal (H1) is used for transmission of orders, to data acquisition and storage in a memory (10). A second clock signal (H2) at higher frequency non-synchronous with the first, is used to read the data stored by each acquisition device. A determined time interval (or window) is assigned to each unit and reading each stored sample is triggered by a command signal marking the beginning of this window. - Application to a seismic transmission system, for example .


The behavior of tubular reinforced concrete columns (TRCC) under cyclic loading is experimentally and numerically investigated. Firstly, four specimens 1/8 of the prototype column are fabricated and tested. In this paper, the hysteretic loops are analyzed just for two specimens, namely tube 1 and tube 3. Then the skeleton curves and hysteretic loops of TRCC are simulated by FEM programming ABAQUS. With suitable selection of the constitutive models for concrete and their parameters, the FEM models can capture the main features of TRCC subjected to monotonic and cyclic loading. Finally, based on the numerical results, the influence of axial compression ratio on the ultimate load is studied. It is confirmed that increasing axial compression ratio is adverse to the seismic performance of TRCC. Both the experimental and numerical results show that TRCC exhibit a moderate ability of energy dissipation.


There have been conflicting reports since 1985 as to the frequency and nature of HIV related testicular (HT) cancer. Two recent reports, and another large series confirm that testicular cancer is more common compared to age matched controls (relative risk 3.9), and seminoma occurs more frequently than non seminoma [1, 2].


This paper adopted a Lebedev Grid(LG)as the new kind of staggered grid scheme for finite-difference(FD)modeling in TTI media.Compared to Virieux′s Standard Staggered Grid(SSG),this scheme can avoid the numerical dispersion from the interpolate wavefield.In process of implementation,we also do some improvements for both the grid dispersion and boundary reflection which are the two key aspects for FD numerical simulation.Numerical experiments testified the validity and feasibility of the optimized algorithm as follows:(1)we derived a new dispersion improvement coefficients(DIC)combining the least square method,which can reduce the numerical dispersion caused by coarse grid,and more effectively than Taylor coefficients with lower storage and higher computational efficiency;(2)we also apply the split Multiaxial PML(M-PML)absorbing boundary condition to LG scheme which can solve the instability in certain anisotropic media caused by the traditional PML method without losing its boundary absorbing effect.


The syntheses and electrochemical/optical properties of some branched and linear 1,1′-substituted ferrocene complexes for molecular electronics are described. Metal centers were extended (and where relevant, connected) by arylethynyl spacers functionalized with m-pyridyl, tert-butylthiol (StBu), and trimethylsilyl (TMS) moieties. Such systems provide two well-defined molecular pathways for electron transfer and hold interesting prospects for the study of new charge transport processes, such as quantum interference, local gating, and correlated hopping events.


A phenomenological study of CP-violating dimension-six operators via the e + e − → ν ¯ ν H process is performed in a model-independent Standard Model effective field theory framework at all energy stages of CLIC using the updated baseline integrated luminosities. All signal and relevant background events are generated in MadGraph and passed through PYTHIA for parton showering and hadronization at parton level. Detector effects are considered via tuned CLIC detector cards in Delphes. Since we reconstruct the Higgs boson from a pair of b-jets, limits on CP-violating dimension-six couplings are obtained at three b -tagging working points: tight, medium and loose defined in the CLIC Delphes card for all three energy stages of CLIC. Our best 95 % C.L. limits at the loose working point (90 % b-tagging efficiency) on ˜ c HW and ˜ c HB are [− 7 . 0 × 10 − 3 ; 7 . 0 × 10 − 3 ] and [− 3 . 0 × 10 − 2 ; 3 . 0 × 10 − 2 ] , respectively at the 3 TeV energy stage of CLIC with an integrated luminosity of 5.0 ab − 1 . Considering a 0.3 % systematic uncertainty from possible experimental sources worsens the limits on these couplings by a factor of two.


Professor Allan Doctor from the University of Maryland School of Medicine shares promising developments regarding the creation of safe and effective artificial blood products. Haemorrhage accounts for approximately 35% of civilian and approximately 90% of military potentially survivable in-field deaths. However, logistic challenges (blood typing, donor availability and cold chain) limit blood deployment in resource-limited and austere environments. As such, a 'universal donor', shelf-stable, portable whole blood analogue (WBA) could transform care in both civilian and military settings.


Quantitative gonadotropin responses to luteinizing hormone‐releasing hormone (LH‐RH) and testicular responses to human chorionic gonadotropin (hCG) have not been reported in patients with the Silver‐Russell syndrome (SRS). We evaluated hypothalamic‐pituitary gonadal functions in a 12‐year‐old boy with SRS, who showed hypergonadotropic hypogonadism.


Abstract Viscoplastic material models are quite important for realistic characterization of deformation behaviour of high-temperature components. However, their material parameter adjustment is expensive and usually requires extensive material testing. The high-temperature deformation behaviour of cast iron GJS X SiMo 4.1 was determined by accelerated complex material testing methods in order to establish a cost-effective identification of viscoplastic material model parameters. Incremental creep tests with mixed-load and temperature steps, together with relaxation and stepped-tensile tests, were carried out in order to determine the stress-dependent creep strain rate at characteristic temperatures and stresses. The cyclic plastic deformation behaviour was studied with complex low-cycle fatigue (C-LCF) evaluations at varying strain rates, amplitudes and temperatures. Thereafter, the results were employed to identify material model parameters of a Chaboche-type viscoplastic material model, which was applied to represent the cyclic deformation and creep behaviour with a correct representation of strain-rate effects at low strain rates.


Sphingosine kinases (SPHK) are important to determine cells' fate by producing sphingosine 1‐phosphate. Reportedly, exogenous SPHK2 overexpression induces cell cycle arrest or cell death. However, the regulatory mechanism of SPHK2 expression has not been fully elucidated. Here, we analyzed this issue using human colon cancer cell lines under various stress conditions. Serum depletion (FCS(‐)) but not hypoxia and glucose depletion increased mRNA, protein and enzyme activity of SPHK2 but not SPHK1. In HCT116 cells mostly used, SPHK2 activity was predominant over SPHK1, and serum depletion increased both nuclear and cytoplasmic SPHK2 activity. Based on previous reports analyzing cellular response after serum depletion, the temporal changes of intracellular signaling molecules and candidate transcription factors for SPHK2 were examined using serum‐depleted HCT116 cells, and performed transfection experiments with siRNA or cDNA of candidate transcription factors. Results showed that the rapid and transient JNK activation followed by CREB activation was the major regulator of increased SPHK2 transcription in FCS(−) culture. EMSA and ChIP assay confirmed the direct binding of activated CREB to the CREB binding site of 5′ SPHK2 promoter region. Colon cancer cells examined continued to grow in FCS(−) culture, although mildly, while hypoxia and glucose depletion suppressed cell proliferation or induced cell death, suggesting the different role of SPHK2 in different stress conditions. Because of the unique relationship observed after serum depletion, we examined effects of siRNA for SPHK2, and found the role of SPHK2 as a growth or survival factor but not a cell proliferation inhibitor in FCS(−) culture. J. Cell. Biochem. 116: 2227–2238, 2015. © 2015 Wiley Periodicals, Inc.


N othing is more frustrating than . expending large amounts of time and energy on developing a quality program and having few or no participants! In the search to discover what went wrong, many occupational health nurses fail to recognize that while the program was well planned, the strategies used to market it were not. Indeed, marketing is often viewed as a vague concept by many health care providers. Yet marketing is nothing more than a systematic means of identifying obstacles and issues, as well as opportunities, that affect an exchange relationship. In a positive exchange relationship, both provider and client receive equal benefit from the program (Kotler, 1982). For example, when an occupational health nurse initiates a health screening program, the positive exchanges for employees and the company are identification and resolution of health problems that could lead to a decline in productivity. The company is also perceived as being responsive to employee needs. In return, the occupational health nurse gains increased visibility as a health promotion agent in the company, and increased contact with key. company personnel. These positive exchanges are the result of careful planning and the preparation of a marketing plan. Six components are required to successfully mar-


The concept of the T-stress as a constraint factor has been extended tonotch tip stress distribution. The effective T-stress (Tef) has been estimated as theaverage value of the T-stress in the fracture process zone. The notch fracture toughnessK ρ , c has been determined using the Volumetric Method. Transferability is thenproposed as a K ρ , c − Tef , c curve and established from 4 specimen types (CT, SENT, DCBand RT) made from X52 pipe steel. Crack stabilisation and crack bifurcation forfracture emanating from notches according to the value of Tef , c is discussed.


In accelerator environments, especially proton machines, high background radiation necessitates the need for quick disconnect vacuum flanges. The use of quick disconnect vacuum flanges significantly reduces the dose of radiation received by workers when installing or removing vacuum chambers in the accelerator. Over the course of many years there have been many designs used for these flanges at Brookhaven National Laboratory for such machines as the Alternating Gradient Synchrotron (AGS), the AGS Booster, and the Relativistic Heavy Ion Collider. Several different flanges with apertures as large as 14 in. in diameter were also evaluated for use in the Spallation Neutron Source project. A summary of various quick connect flanges as well as some commercially available flanges and the evaluation results are presented.


Optical illusion graphics are featured by the design characteristics of distortion of space, decomposition of objects, and deformation of shape. The objective of design education is to establish the concept of plane composition, which can be achieved by understanding the design of optical illusion graphics. The design education of the past mainly investigated optical illusion graphics of visual interest from the perspective of visual psychology. However, to enable students to actually implement the designs of optical illusions, they require design methods. The purpose of this study is to propose the design methods of ambiguous graphics using the object allocation method of graphic design. This study is divided into two stages. Stage 1 analyzed the object allocation method to propose the design methods of ambiguous optical illusion graphics. Stage 2 analyzed the actual implementation of design, and divided the subjects into an experimental group and a control group, in order to verify the practicability of the design methods of optical illusion graphics, as proposed in this study. Research results: 1) the design methods proposed in this study can define three composition methods, as based on location, direction, and shape combinations of objects: (1) separation; (2) adjacency; (3) overlapping. The results of the actual implementation of design showed that "adjacency" (56.7%) was most frequently used as the composition method in the control group, while "overlapping" (63.0%) was most frequently used in the experimental group. Moreover, compared with the control group, who were not instructed in the design methods of composition, the actual designs of the experimental group were featured by diversified design characteristics and types. The practicability of the application of the three composition methods, separation, adjacency, and overlapping, as proposed in this study, to art education was verified. In addition, they can be used as assessment methods for analyzing optical illusion graphics.


This research discusses about the Police's Roles in Crime of Organ and/or
Body Network Buying and Selling for Organ Transplantation.
This research focuses on one problem formulation. The problem is to figure
out the police's roles in Organ and/or Body Network Buying and Selling for
Organ Transplantation.
This research is normative law research which is focused on norm of positive
law in the form of supporting laws and regulations. The source of this research
uses secondary data which consists of primary law source and secondary law
source and is supported by interviewing the interviewee.
The result of the research is that the Police Department has roles related to the
crime that is national security and order maintenance from the obstacles, threats,
challenges and disturbance. It can come first from the accusation from the society
or the victim's family as the basic for the Police Department to follow the case up.
After getting the accusation, the Police Department will do some investigations
and follow it up to the court.


Based on literature review, this paper outlined the research advance in the study of vulnerability. This study further made clear the implication of regional development's vulnerability, analyzed the mechanism of regional development's accumulated vulnerability and designed an index system for evaluating accumulated vulnerability. At last this article also evaluated and predicted the accumulated vulnerability of Bejing-Tianjin-Hebei Metropolitan Circle using Fuzzy Comprehensive Evaluation Method and Grey System Model. The results showed that there was significant difference of vulnerability within Beijing-Tianjin-Hebei Metropolitan Circle and the vulnerability was gradually increased and accumulated.


Star clusters are efficient factories of binary black hole (BBH) mergers at low redshifts (z < 0.2). Using numerical models of star clusters spanning a wide range in stellar metallicities (Z) we study the effects of a parent cluster's metallicity on the masses of BBHs merging in the local universe. We connect BBH merger times (tdelay) obtained from models of a given metallicity to the corresponding merger redshifts using a distribution of formation epochs for clusters of that stellar metallicity derived based on the cosmological star formation rate and metallicity evolution. We find that the mass distributions for BBHs merging in z < 0.2 can have significant overlap even when created in clusters of widely different stellar metallicities. This makes it hard to infer metallicity from the masses of individual merging BBHs. As the cluster metallicity decreases, the peaks and distributions for masses of its BBHs merging in z < 0.2 move to higher values, but for Z/Z . 0.05 they become insensitive to the cluster metallicity. We compare the intrinsic mass distributions for BBHs merging in z < 0.2 from our models with those observed. Masses of LVT151012 and GW151226 are similar to the peaks of the intrinsic mass distributions for models with Z/Z = 0.25 and 0.75, and are within 1σ for models with Z/Z ≤ 0.25 and Z/Z ≥ 0.5, respectively. GW150914 is more massive (beyond 1σ) than typical BBHs merging in z < 0.2 even for the lowest metallicity (Z/Z = 0.005) clusters we consider, but is within 2σ of the intrinsic mass distributions from clusters with Z/Z ≤ 0.05. Of course, accounting for aLIGO detectability would push the intrinsic distributions towards higher masses, hence the detection of merging BBHs as massive as GW150914 would be less rare. Since cluster dynamics typically increases BBH masses via exchange encounters relative to what could form in isolation, mergers of BBHs as massive as GW150914 in z < 0.2 is likely intrinsically rare in general.


In this study, we have applied a second high-stress contect etch stop layer (CESL) in nickel fully silicide complementary metal–oxide–semiconductor field-effect-transistors (Ni FUSI CMOSFETs) and investigated performance characteristics, such as driving capacity, leakages, low-frequency noise (LF noise), and capacitance–voltage (C–V) characteristics. In Ni FUSI nMOSFETs, the effect of the second CESL on the improvement of carrier mobility is apparent. However, the second CESL also induces defects and junction leakages, resulting in a high LF noise and a low accumulation capacitance. Since we adopted the tensile-stressed second CESL, which is profitless improving the performance of pMOSFETs (should be compress-stressed) and apparently degrades the devices' driving capability, leakages, and LF noise of the devices. Furthermore, the FUSI process does not induce apparent damage that increases the gate leakages of both Ni-FUSI nMOSFETs and pMOSFETs.


A 3-yr study was conducted to determine seasonal abundance of major pentatomid, noctuid, and mirid pests in a multicrop environment in south Arkansas. Replicated field plots (~0.1 ha) containing co...


Management of emerging technologies such as business electronic mail (email) has been a perennial challenge in many developing countries. Amongst challenges to effective management of email are lapses in legal, policy and procedural frameworks, skills and information and communication technology infrastructural deficiencies. The national archival authority in Zimbabwe, the National Archives of Zimbabwe (NAZ), has received a lot of criticism for failing to give direction and help public institutions in managing email in accordance with the provisions of Section 6 of the NAZ Act (1986) which gives the NAZ a superintending role in the management of records in any format in the country. This paper traces the current interventionist role that the NAZ is playing with regards to the management of email. The article focuses on Zimbabwe's central government where head offices of 12 out of 22 government ministries participated in the study. This mixed methods research sought to tackle the research question from both quantitative and qualitative perspectives. A total of 240 records officers, administration officers and information technology officers completed questionnaires while seven NAZ archivists, the NAZ director, one Administration Director and one Information Technology Director from central government participated as interviewees. The study revealed that NAZ had of recent begun to play a more proactive role in helping central government manage email properly and professionally although the assistance was not vibrantly felt across the length and breadth of the entire public service.


Europe during the one thousand years from A.D. 900 appears to be the best region and period for a study of the environmental factors determining the evolution of a nation. Seventy-four homogeneous regions appear. Grouping and indexing these according to length of national life, or independent government, two distinct zones are formed: a zone of high-index nations, extending from Iceland to Aragon; and a low-index zone from Lapland to Morea and Sicily. For simplification the three medium-index zones are for the most part ignored, leaving the two contrasting groups which may be used a number of correlations. As for religion and race the high-index regions appear to be strongly Protestant and Nordic, and the low-index regions strongly Greek Church and Alpine. No causal relationship is assumed. Good rainfall seems favorable to national continuity, temperature has practically no bearing, and rugged regions on the whole are not favorable for continued national growth. Death-rates are considerably lower in regions of high than in those of low national index.


A sufficiently magnetized local supercluster can explain the spectrum and angular distribution of ultrahigh energy cosmic rays. We show that the spectrum of extragalactic cosmic rays with energies below {approximately}10{sup 20}thinspeV may be due to the diffusive propagation in the local supercluster with fields of {approximately}10{sup {minus}8}{endash}10{sup {minus}7}thinspG. Above {approximately}10{sup 20}thinspeV, cosmic rays propagate in an almost rectilinear way which is evidenced by the change in shape of the spectrum at the highest energies. The fit to the spectrum requires that at least one source be located relatively nearby at {approximately}10{endash}15thinspMpc away from the Milky Way. We discuss the origin of magnetic fields in the local supercluster and the observable predictions of this model. {copyright} {ital 1998} {ital The American Physical Society}


BACKGROUND & AIMS
Rheumatoid arthritis (RA) is complicated by cytokine-driven alterations in protein and energy metabolism and consequent muscle wasting (cachexia). The aim of this randomised controlled trial was to investigate the efficacy of a mixture of beta-hydroxy-beta-methylbutyrate, glutamine and arginine (HMB/GLN/ARG) as nutritional treatment for rheumatoid cachexia.

METHODS
Forty RA patients supplemented their diet with either HMB/GLN/ARG or a nitrogen (7.19 g/day) and calorie (180 kcal/day) balanced mixture of alanine, glutamic acid, glycine, and serine (placebo) for 12 weeks. Body composition and other outcomes were assessed at baseline and follow-up, and analysed by mixed ANOVA.

RESULTS
Dietary supplementation with HMB/GLN/ARG was not superior to placebo in the treatment of rheumatoid cachexia (groupxtime interactions P>0.05 for all outcomes). Both amino acid mixtures significantly increased (main effect of time) fat-free mass (727+/-1186 g, P<0.01), total body protein (719+/-1703 g, P=0.02), arms (112+/-183 g, P<0.01) and legs (283+/-534 g, P<0.01) lean mass, and some measures of physical function. No significant adverse event occurred during the study, but patients in the HMB/GLN/ARG group reported fewer gastrointestinal complaints compared to placebo.

CONCLUSIONS
Dietary supplementation with HMB/GLN/ARG is better tolerated but not more effective in reversing cachexia in RA patients compared to the mixture of other non-essential amino acids used as placebo. Further controlled studies are necessary to confirm the beneficial anabolic and functional effects of increased nitrogen intake in this population.


Terzaghi's one-dimensional consolidation theory is modified based on the modified non-Darcy seepage equation considering the initial hydraulic gradient,and solved by using the finite volume method in this paper.The analytical results indicate that,for the soil with the initial hydraulic gradient greater than zero,the rate of consolidation is less than that by applying Terzaghi's consolidation theory,and the initial hydraulic gradient,the thickness of the layer and the ground pressure,besides the consolidation coefficient,also play important roles in the process of consolidation.In addition,it is validated that there exists some residual pore pressure which cannot be completely dissipated in the soil layer at the end of primary consolidation.


This paper concerns the evaluation of the normal inhomogeneity of functional gradient materials by means of spectrum analysis of ultrasonic waves. We first derive a theoretical method for the measurement of continuously changing acoustic impedance in the normal direction by spectrum analysis, by integrating the inverse Fourier transform of the ratio of the spectrum of the reflected wave to that of the incident wave. Next we apply this method to materials such as clad material, functional gradient material and powder compact, and it is proven to be useful in nondestructive inspection.


The finite element model of wing girder is built with MSC Patran, and by using MSC Nastran the optimization is designed. The structural weight, area of girder edge and thickness of web are satisfied with the need of engineering. The wingtip deformation is also satisfied with the distortion.


Objective To explore leadership styles,organizational support,organizational commitment and employee engagement relationship and provide a theoretical basis for improving employee engagement.Methods Literature research,analysis department employee engagement situation at this stage.Results Employee engagement at a high level,there are still negative factors,leadership style,organizational support,organizational commitment was positively correlated with employee engagement.Conclusion The department managers should give employees more organizational support,organizational commitment,change leadership style,to further improve employee engagement.


In relativ kurzem zeitlichem Abstand wurden in Rom zwei Medieninstruktionen veroffentlicht. Am 22.02.1992 erschien nach einem mehr als funfjahrigen Diskussionsprozes der Mitglieder des "Papstlichen Rates fur die sozialen Kommunikationsmittel" und der entsprechenden internationalen Beratergremien endlich das lang erwartete Nachfolgedokument zu Communio et progressio: die Pastoralinstruktion "Aetatis novae" zur sozialen Kommunikation zwanzig Jahre nach Communio et progressio. (...)  English The new pastoral instruction "Aetatis novae" has not taken back or canceled anything from "Communio et progressio". This is the official interpretation of the New media document. This interpretation does not stand up to critical examination, especially when taking into account the instruction published at the same time by the congregation of faith which lists the currently operative law of CIC in dealing with the instruments of social communication. One has to make a positive note of the realistic view of the mass media in "Aetatis novae" in which theological excessiveness is avoided. In "Aetatis novae" one can note a decisive shift of emphasis in comparison with "Communio et progressio" as regards the Statements on inner-ecclesiastical communication. In this sphere the statements of "Aetatis novae" come close to certain statements of the instruction of the congregation of faith as regards the collected legal regulations. Communication is reduced to the communication of the truth from top to bottarn which, when in doubt or in conflict, is to be achieved with the means of the CIC. The backgmund of this completely one-sided model of communication is formed by the understanding of a church that teaches and administers the truth. The concept of evangelization for which the instruments of social communication are, according to "Aetatis novae", insdispensable nowadays, is also determined by this ecclesiological narrowness.


Muscle imaging has extraordinarily developed in the past decade. Over the past years, the use of magnetic resonance imaging (MRI) to identify particular involvement of the muscles of the body is becoming a fundamental diagnostic tool. Compared with computed tomography, MRI is a nonradiating technique and offers better tissue contrast for muscle disorders. Different patterns of involvement in T1 turbo spin echo (TSE) sequences have been described in several hereditary myopathies,1,2 with additional interest of short tau inversion recovery (STIR) or T2 fat saturation techniques in several of them (p.e. facio-scapulo-humeral (FSH),3 dysferlin4) or in inflammatory myopathies.5 The particular combination of signal and volume abnormalities, the distribution of fatty infiltration inside a muscle, or the "texture" may give highly informative data to guide the genetic studies to perform in a patient. As a result of these developments, muscle MRI is being increasingly used in clinical practice to approach the diagnosis of hereditary myopathies, sometimes sparing the need for a muscle biopsy or guiding the muscle to sample. In the pediatric patient, MRI has shown great interest in children with suspicion of earlyonset myopathy, in particular when they present certain features such as rigid spine stiffness, hyperlaxity, or limb joint contractures.6,7 In the study on 28 children by Kana et al,8 the integration of this new tool in the diagnostic processes of the everyday neuromuscular clinic is nicely shown. In a series of children with suspected congenital myopathy or muscular dystrophy, MRI was contributory to the diagnosis in one-third, and in one-fourth, it led directly to genetic confirmation. In several patients,MRI revealed crucial information, not identified by other classical tests. Very remarkably, MRI not only allowed exploring the possibility of muscle diseases but also showed consistency with neurogenic disorders as spinal muscular atrophy, or pointed to the possibility of a myasthenic syndrome in children with no significant signal abnormalities who still were markedly weak. As shown in this series, imaging may be essential to investigate the implication of large genes difficult to analyze by standard techniques (RYR1, NEB), to target gene sequencing in disorders genetically heterogeneous (three COL6 genes in Ullrich CMD/Bethlem myopathy, nemaline myopathy, centronuclearmyopathy, limb girdlemuscular dystrophies), or in those with low specificity of atomopathology or immunostaining studies (LMNA, SEPN1). Moreover, MRI shows sometimes a higher diagnostic impact in patients affected with myopathies usually diagnosed by specific biopsy findings (RYR1, calpain) but in whom the muscle specimen remained noninformative or nonconclusive. Limitations of muscle MRI may be diverse. Time of scanning, need of sedation (young children, noncooperative patients), technical settings and logistic difficulties, metallic implants, ventilation during the procedure, and severe limb contractures may interfere or even prevent the examination. In our experience, these difficulties may be often solved, provided an adapted setting is defined and solutions anticipated. Therefore, close interaction between clinicians and radiologists is mandatory, with bidirectional exchanges. Later on, a supplementary limitation is linked to the complexity for image interpretation, not only related with the quality of images but also of the availability of data in literature. Although it is true that several publications report relatively distinct patterns of involvement in different myopathies, most of them concern a small number of patients and are Editorial Comment


[1] In the paper ''Latitudinal dependence of diapycnal diffusivity in the thermocline observed using a microstructure profiler'' by T. Hibiya et al. (Geophysical Research Letters, 34, L24602, doi:10.1029/2007GL032323) there were textual errors inadvertently overlooked during the production proofing process. [2] The second sentence in Paragraph 5 should read as follows. In the present study, we deployed the velocity microstructure profiler TurboMAP-D to a depth below the main thermocline at 53 locations in the interior Pacific Ocean between 53 N and 10 S (Figure 1). [3] Paragraph 9 should read as follows. Figure 3 shows the average diapycnal diffusivities over the depth range of 1000 m to 1600 m inferred from microstructure observations (hereinafter referred to as Kr ) and those inferred by incorporating XCP data into Gregg's fine-scale parameterization [Gregg, 1989] (hereinafter referred to as Kr ). [4] The third sentence of paragraph 10 should read as follows. The latitudinal distribution of Kr MSP thus obtained from microstructure observations is in qualitative agreement with predictions based on parameterized estimates Kr PRM at midand high-latitudes (poleward of 20 N) [Nagasawa et al., 2002; Hibiya and Nagasawa, 2004; Hibiya et al., 2006] and previous microstructure observations at low latitudes (equatorward of 20 N) [Gregg et al., 2003], although finescale parameterizations overestimate diapycnal diffusivities by a factor of 2–3. [5] The first sentence of paragraph 12 should read as follows. By deploying the un-tethered free-fall microstructure profiler called ''TurboMAP-D'' at 53 locations in the interior Pacific Ocean between 53 N and 10 S, we have examined the efficacy of the latitudinal dependence of diapycnal diffusivity in the main thermocline predicted based on parameterized estimates at midand high-latitudes [Nagasawa et al., 2002; Hibiya and Nagasawa, 2004; Hibiya et al., 2006] and previous microstructure observations at low-latitudes [Gregg et al., 2003]. [6] The second sentence of paragraph 13 should read as follows. One of the strong candidates that might make up for the deficiency of diapycnal mixing in the main thermocline is thought to be intense diapycnal mixing above abyssal rough bottom topography [Polzin et al., 1997; Ledwell et al., 2000]. [7] The pagination for Furuichi et al. [2005] was incorrect. The reference should read as follows.


Enantioimerically pure 1, l'-bi-2-naphthol (BINOL) 1 and its derivatives are important chiral ligands and auxiliaries for a number of asymmetric transformations1 such as aldol condensations, alkylations, Diels-Alder reactions, Michael additions, epoxidations, etc. Optically pure 1 and their derivatives have also been used extensively in chiral recognition, chiral separation and in the construction of functionalised materials2. Furthermore, (R)-and (S)-BINOL are also fundamental starting materials for the synthesis of a large variety of other chiral binaphthyls such as MOP (2c), NOBIN (2d) and BINAP (2e). As a result the development of efficient and economic methods for the preparation of optically pure 1 has attracted much attention in recent years3 and novel methods for the resolution of( ±)-1 continue to be developed.……


A process for the isolation of nontoxinogenic V. Cholerae Strain and a process for preparing a cholera vaccine from said V. Cholerae Strain, said process comprising (a) isolating V cholerae from the stool of a patient suffering from cholera by Spreading the Stool on a Selector medium specific for V. cholerae, (b) separating the non-toxinogenic V. cholerae strain from the population of the V cholerae strains isolated in step (a), and (c) incorporating immunogenic cholera toxin (ctX) B Subunit gene into the chromosome of the Strain by conventional methods to produce the vaccine.


Apple slices dried at 60C were rehydrated at 20, 40 and 60C to analyze the influence of processing temperature on quality attributes and rehydration kinetics. Diffusion coefficient increased with process temperature from 1.36 to 2.37 × 10−9 m2/s. The Weibull model obtained the best fit quality for the experimental data based on statistical test, chi square. Color was not recovered during rehydration and the results indicated that the use of low temperatures is more adequate. Water-holding capacity decreased, while rehydration ratio increased with increasing rehydration temperature, indicating structural modifications. Increasing rehydration temperatures led to a reduction in the glass transition temperature and hardness values of samples. The radical-scavenging activity showed higher antioxidant activity at higher rehydration temperatures rather than at lower temperatures. It was found that rehydration temperature modifies the cell structure and antioxidant capacity of final product.


Optimal conditions for milling carbon/epoxy composite material were established by response surface methodology. The combination of cutting parameters such as cutting speed (Vc) and chip thickness (h) was varied at design points of a central composite design. Significant regression models describing the changes of vibration level, delamination of composite, cutting force, workpiece temperature were developed with the coefficient of determination greater than 0.90. Results suggested that beyond a threshold of vibration, the occurrence of delamination is regular. Vibration criterium was defined from the observations of the workpiece according to the delamination defect. The optimum milling conditions were achieved by means of graphical techniques using design contour plots. The best combination of process variables was found according to the cutting conditions.


This paper has introdused the improvement in the electricial control system of the spiral unloading machine in BX STEEL No.3 sintering shop,as to explore the safty and credibility in the circulating of electrical equipments,so as to raise the working efficiency.


Background: Patient satisfaction is at the forefront of quality care and patient outcomes. The literature identifies the discrepancy between nurse and patient perceptions in a variety of care settings; few studies have investigated the perceptions of care in a critical care unit. Understanding the perceptions in a critical care unit is necessary to optimize organizational performance related to quality, safety, patient-centered care, and efficiency. Objective: The purpose of the study was to determine whether a discrepancy exists between what patients and families perceive as satisfaction with their care as compared with the nurses' perception of what constitutes positive patient satisfaction in a medical critical care unit. Methods: A cross-sectional, prospective study was conducted to assess patient-perceived satisfaction with nursing care versus nursing perceptions in the medical intensive care unit. A convenience sample of patients and/or family members and the nurses providing their care was conducted. The validated Patient Satisfaction with Nursing Care Quality Questionnaire and Nurse's Assessment of the Patient's Expectations Questionnaire were used to assess perceptions. Patients and/or their family members and nurses' responses were evaluated as matched pairs. The data were analyzed using Spearman correlation. Results: Forty-eight matched pairs of questionnaires were completed. There was not a correlation (r = 0.135; 95% confidence interval, j0.16 to 0.41; P = .363) between the overall patient and nurse averages for common questions. The analysis of the individual patient and nurse items revealed statistically significant correlations between only 2 of the 19 items, information given (P = .027) and recognition of opinions (P = .043).


The effects of Dufour and Soret on a steady two dimensional MHD free convection flow past a semi-infinite vertical porous plate embedded in a porous medium have been studied numerically. The governing nonlinear partial differential equations are dimensionless form and transformed by a similarity transformation into a system of ordinary differential equations. The resulting non-linear coupled equations are solved under appropriate transformed boundary conditions using the Crank-Nicolson method. The dimensionless velocity, temperature and concentration profiles are displayed graphically showing the effects for the different values of the involved parameters of the problem. Introduction The study of Magnetohydrodynamic (MHD) flows have stimulated extensive attention due to its significant applications in three different subject areas, such as astrophysical, geophysical and engineering problems. Free convection in electrically conducting fluids through an external magnetic field has been a subject of considerable research interest of a large number of scholars for a long time due to its diverse applications in the fields such as nuclear reactors, geothermal engineering, liquid metals and plasma flows, among others. Fluid flow control under magnetic forces is also applicable in magnetohydrodynamic generators and a host of magnetic devices used in industries. Steady and transient free convection of an electrically conducting fluid from a vertical plate in the presence of magnetic field was studied by Gupta1. Lykoudis2 investigated natural convection of an electrically conducting fluid with a magnetic field. Takhar et al.3 computed flow and mass transfer on a stretching sheet under the consideration of magnetic field and chemically reactive species. They focused that the energy flux can be produced by both of the temperature gradient and concentration gradient. The energy flux caused by concentration gradient is called Dufour effect and the same by temperature gradient is called the Soret effect. These effects have a vital role in the high temperature and high concentration gradient. The significant Soret effects in convective transport in clear fluids have been found in the work of Bergaman and Srinivasan4 and Zimmerman et al.5. The effect of magnetic field on heat and mass transfer from vertical surfaces in porous media considering Soret and Dufour effects have been performed by Postelnicu6. Alam et al.7 analyzed the Dufour and Soret effects on steady MHD combined free forced convective and mass transfer flow past a semi-infinite vertical plate. Jha et al.8 included Soret effects free convection and mass transfer flow in the Stokes problem for an infinite vertical plate. An analysis of the steady two-dimensional flow of an incompressible viscous and electrically conducting fluid over a non-linearly semi-infinite stretching sheet in the presence of a chemical reaction and under the influence of a magnetic field have been carried out by Raptis and Perdikis9. Acharya et al.10 studied heat and mass transfer over an accelerating surface with heat source in the presence of suction and blowing. Anghel et al.11 investigated the Dufour and Soret effects on free convection boundary layer over a vertical surface embedded in a porous medium. Mohammadein et al.12 found the result of heat transfer in a micropolar fluid over a stretching sheet with viscous dissipation and internal heat generation. Helmy13 presented the effects of the magnetic field on a non-Newtonian conducting fluid past a stretching plate. The goal of the present work is to investigate the effects of Dufour number and Soret number in the presence of magnetic field for MHD free convection flow and mass transfer along a stretching sheet. However, the interaction of Soret and Dufour effects on steady MHD free convection flow in a porous medium has received a little attention. Hence, the object of the present problem is to analyze the Soret and Dufour effects on steady MHD free convection boundary layer flow past a semi-infinite moving vertical plate embedded in a porous medium. The governing equations are transformed by similarity transformation and the resultant dimensionless equations are solved numerically using the Crank-Nicolson method. The effects of various governing parameters on the velocity, temperature, concentration are shown in figures and analyzed in details. Flow Analysis A steady two dimensional flow of an incompressible and electrically conducting viscous fluid, along a semi infinite vertical porous flat plate embedded in a porous medium is considered. The xaxis is taken on the infinite plate, and parallel to the free-steam velocity which is vertical and the y-axis is taken normal to the plate. A magnetic field β0 of uniform strength is applied transversely to the direction of the flow. Initially the plate and the fluid are at same temperature T∞ in stationary condition with concentration level C∞ at all points. For t>0, the plate starts moving impulsively in its own plane with a velocity U0, its temperature is raised to Tw and the concentration level at the plate is raised to Cw. The flow is assumed to have constant properties except that the influence the density variations with temperature and concentration, which are considered only in the body force term. Under the above assumptions, the physical variables and functions of y and t only. Assuming that the Boussinesq and boundary-layer approximation hold and using the Darcy-Forchheimer model, the basic equation which govern the problem are given by x u ∂ ∂ + y v ∂ ∂ = 0 ......1 u x u ∂ ∂ + v y v ∂ ∂ = v 2 2 y v ∂ ∂ + β g (T T∞) + * β g (C C∞) k vu ...2 u x T ∂ ∂ + v y T ∂ ∂ = α 2 2


A finite difference method was derived for the analysis of time domain electric field integral equation(TDEFIE) of thin wire structures. This method is easier to numerate implementation than the traditional time domain method of moment. Three classical electromagnetic radiation/scattering cases of thin wires were considered for comparison. The results confirmed that the finite difference scheme is very efficient for the solution of TDEFIE of thin wire.


ABSTRACT
The rational use of antibiotics is prescribing antibiotics, dosage, duration, safe and affordable
interval of medicine use by the patient. The purpose of this research is to know the quality of
antibiotics use to the post-surgery patients in BDH Surabaya for 2016. This is a cross-sectional
design, collecting the data from the medical records of post-surgery patients who received
antibiotics in BDH Surabaya during 2016. The sample was taken by proportional stratified
sampling. The quality of antibiotics use was analyzed by using Gyssens. The result showed that
from reviews those 97 medical records, the total of the rational use of antibiotics in
BDH Public Hospital Surabaya were 59.7% (category 0) and 40.3% included to the category II-IV.
The use of antibiotics with incorrect dosages (category IIA) 4.8%, inappropriate administration
intervals (category IIB) 7.7%, too long use (category IIIA) 16.3%, too short use (category IIIB)
1.9%, there was more effective antibiotics (category IVA) 2.9%, and there was other cheaper
antibiotics (category IVC) 6.7%. Based on the quality of the use of antibiotics in post-surgical patients in BDH Hospitals at 2016 period, that appropriate Gyssens category rational antibiotic
use was 59.7% and the results are not rational as much as 40.3%.

Keywords: antibiotic, rational, quality, Gyssens


Forty teacher education students and 40 middle schoolers who have moderate handicaps used electronic mail to learn some important lessons. Ms. Stivers provides the details. There doesn't appear to be much connection between huge, high-speed mainframe computers with nearly infinite memory and the task of helping college students become teachers who will nurture academic and social development in children with special learning needs. But when Marist College (the small liberal arts college in Poughkeepsie, New York, where I teach prospective elementary and special education teachers) won a grant from IBM, I did what all veteran teachers do: I made use of the resources at hand. Teachers at nearby New Paltz Middle School and I arranged for the 40 students enrolled in my junior-year methods courses to be paired with 40 "writing partners" from the teachers' classes for students with moderate handicaps. Using the electronic mail facility available on our mainframe, the pairs communicated often and on a variety of topics. At first, letters went back and forth weekly. However, as friendships began to develop, some pairs wrote daily. The content of some of the exchanges was shaped by the assignments I had built into my course requirements - assignments that had been further tailored by the middle school teachers' objectives for their students. Thus some letters were really lessons. If the teacher had specified that the student needed to work on writing descriptive sentences, the college student would model descriptive sentences, pointing out what made them descriptive, and then elicit similar writing from the middle school student, perhaps by asking questions about activities and interests that the child had mentioned in earlier letters. My middle school colleagues and I were glad to see that both sets of students were growing more comfortable with the technology and even rather creative in its use - devising e-mail shorthand and symbols, like a smiling face made from punctuation marks. But the most gratifying part was watching each group reach out to and begin to affect the other. Here is a small sample of the kind of letters that my students received. (The middle schoolers' original spelling and punctuation have been retained, but the names are pseudonyms.) Dear Karen, I got your leter. Ilove to read it. . . . My favorite team is the Bulls. My real name is David. Sincerely, David Richard Antoine M. Dear Karen, How was your weekend? I have the answer to your question. The chicago Bulls have good defense. The chicago Bull has good hoop shooters. Michael Jordam is a good layup shooter. The Chicago Bulls are a friendly team. Sincerely, Richard Dear Karen Hi How are you? I am doing fine. My favorite movie is White Men Can't Jump. Did you know the Chicago Bulls lost ten games this season? . . . My mom and dad went to jamaica Because they were a death in the family. My sister sue sayed me. I can't wait to read your letter. Sincerely, Richard Dear Karen, I got your letter today. I can't wait to meet you in may I don't know what time in may. Do you know when it is? when you go on A picnic you need a blanket. And a lot of like fruit salad and water melon. I can't wait. Sincerely, Richard "As weird as it may sound," Karen wrote in her journal, "this 11-year-old child gave me a good feeling about myself. Richard's trust in me and his excitement about getting my letters really boosted my self-esteem." "I am counting the days until I meet my writing partner," wrote Marianne. "I feel like I've become so close to her, and we have not even met. I check every day to see if she has written to me. When she tells me that she is having a really bad week, I'm sad, but it helps to realize that I may be helping her a little bit. …


This report describes inverse spectral analysis of diffuse-reflectance spectra measured using Infrared Backscatter Imaging spectroscopy (IBIS). In IBIS, a tunable infrared laser illuminates a target while an infrared camera detects the backscatter. Target analytes are identified by analyzing the pattern of absorption dips in the detected backscatter and comparing them to the known or simulated reflectance spectra of hazardous materials. The backscatter spectrum is comparable to diffuse reflectance measured using a Fourier transform infrared (FTIR) spectrometer. The analysis methodology applied here entails iterative adjustment of spectra using phenomenological backgrounds. and estimation of absorbance using the Kubelka-Munk (KM) theory of diffuse reflectance. Applying spectrum-feature enhancement, measured with a field spectrometer, can provide a better estimation of dielectric response, which is for comparison to reference dielectric functions, for identification of target materials.


The invention relates to a device for discharging a power network or a capacitive component, comprising a switchable resistor (2). The discharge circuit has extremely low losses and works reliably if the switchable resistor (2) comprises a PTC resistor (R1) and a switch (T1) the gate terminal (G) of which is supplied by the mains voltage.


The use of electricity distribution networks for communications and data transfer has been an ambition of power companies for many years. The first technology patent on the subject of sending signals down power lines dates back to 1899. However, until recently, the prospect of high-speed, two-way communication network has been a dream of utilities. That dream is now being turned into reality.


A revi-sion As a relatively mature Coastal Web Atlas the Oregon Coastal Atlas project has encountered and overcome many technical and institutional challenges and has incorporated many lessons learned into its current design and approach. The Atlas currently hosts an archive of over 3,700 individual coastal data layers (including orthophotographs) and serves a variety of static and dynamic map products as well as informational tools focused on coastal places and topics. ABSTRACT This coastal web atlas case study for Oregon, USA, featuring the Oregon Coastal Atlas (OCA), describes a web site where people interested in coastal and marine information for the Oregon coast can find, learn about, and utilize data about the various resources and management issues in the Oregon coastal zone. The OCA currently hosts an archive of over 3,700 individual coastal data layers (including or-thophotographs) and serves a variety of static and dynamic map products as well as informational tools focused on coastal places and topics.


Balanced Scorecard system  may  affect the company's productivity in the forms of financial perspective, internal business process perspective, and learning as well as growth perspective. A manager shall consider its benefits before implementic the system to the company. This research uses quantitative data obtained from accounting and producting staffs. Data are  analyzd by  using statistical experiment as the analysis tool to test the hypothesi using F test to find out the correlation of research variable simultaneously,  and t-test to find out the relationship of multiple linear regression of equality partialy. And the result is that  there is correlation between company's productivity and perspectives in Balanced Scorecard. The dominant effect toward the company's productivity is learning and growth perspective and internal business process perspective.


All investors and investment managers are searching for "value," but to succeed, they need to identify where best and most opportunely to look for value. "Values" are opportunities that are overlooked, ignored, or poorly analyzed, and today, investors must look for values in the global market. Success also requires that investors stick to their investment principles while they respond to change and that they apply careful, comprehensive, systematic, flexible analysis.This presentation comes from the Exploring the Frontiers of Global Equity Investing conference held in Singapore, on November 29 - December 1, 1995.


We show that any locally conformally flat ancient solution to the Ricci flow must be rotationally symmetric. As a by-product, we prove that any locally conformally flat Ricci soliton is a gradient soliton in the shrinking and steady cases as well as in the expanding case, provided the soliton has nonnegative curvature. In this paper, we study ancient solutions to the Ricci flow. We recall that a time-dependent metric g(t) on a Riemannian manifold M is a solution to the Ricci flow if it evolves by the equation @ @t g(t) = −2Ric g(t) . A solution is called ancient if it is defined for every negative time. Ancient solutions typi- cally arise as the limit of a sequence of suitable blow-ups as the time approaches a singular time for the Ricci flow. In dimension two there exists a compact, rotationally symmetric, ancient solution due to King (22), Rosenau (32) and Fateev, Onofri and Zamolodchikov (18). In dimension three Perelman (30) constructed a compact, rotationally symmetric, ancient solution on the three sphere. In the non-rotationally symmetric case, the first construction is due to Fateev (17) in dimension three. Motivated by this construction, Bakas, Kong and Ni (3) produced high dimensional compact ancient solutions to the Ricci flow which are not rotationally symmetric. In dimension two, Daskalopoulos, Hamilton and Sesum (15) have obtained a complete classification of all compact ancient solutions to the Ricci flow. Ni (27) showed that any com- pact ancient solution to the Ricci flow which is of type I, is k-noncollapsed, and has positive curvature operator has constant sectional curvature. In (6) Brendle, Huisken and Sinestrari proved that any compact ancient solution which satisfies a suitable pinching condition must have constant sectional curvature. In this article, we show that any complete ancient solution to the Ricci flow in dimension n ≥ 4 which is locally conformally flat along the flow must be rotationally symmetric. Theorem 1.1. Let (M n ,g(t)), n ≥ 4, be a complete ancient solution to the Ricci flow which is locally conformally flat at every time. Then (M n ,g(t)) is rotationally symmetric. The non-rotationally symmetric examples of Bakas, Kong and Ni show that the locally conformally flatness assumption cannot be removed. The proof of Theorem 1.1 relies on a previous work of the first two authors (11) about the behavior of the Weyl tensor under the


ivabradine in 126 Japanese patients with symptomatic HF and ejection fraction <35% in sinus rhythm with heart rate ≥75 beats/min.8 The initial dose was 2.5 or 5 mg twice daily (BID) of ivabradine, and the dose was increased up to a final dose of 7.5 mg BID in 73.8% in the 2.5-mg and in 84.6% in the 5-mg groups. The heart rate reduction of 16 beats/min after 6 weeks after ivabradine treatment was greater in this study compared with the BEAUTIFUL and SHIFT trials, which was comparable to data from the subgroup analysis of SHIFT (baseline heart rate ≥75 beats/min).7 Because ivabradine is an open-channel blocker and inhibits the If current in a usedependent manner (Figure 1), it is reasonable that patients with high resting heart rates are suitable for ivabradine treatment.9 It is well known that resting heart rate is a strong predictor, as well as a risk factor, of mortality and morbidity in patients with HF.10 The CHART-2 study, one of the largest HF cohort studies in Japan, demonstrated that patients with systolic blood pressure <89 mmHg, or those with systolic blood pressure 89–115 mmHg and heart rate >76 beats/min, are defined as a high-risk group with a mortality rate >20% using CART analysis.11 Although β-blockers are widely used to reduce mortality in patients with HF and systolic dysfunction,12 patients with high resting heart rates despite usage of β-blockers or those with β-blocker intolerance because of low systolic blood pressure seem to have a poor prognosis. In this phase II study of ivabradine,8 117 (92.9%) patients had β-blocker therapy and 74 of 117 (63.3%) patients were treated with at least 50% vabradine is a novel heart-rate reducing agent that inhibits the pacemaker current (If) of cardiac sinoatrial node cells with limited inotropic side effects. Ivabradine is a promising agent that prevents myocardial ischemia and treats symptoms in patients with stable angina pectoris, where heartrate reducing is beneficial because it decreases the oxygen requirement of cardiac muscle.1 In the BEAUTIFUL trial, ivabradine did not show clinical benefit in patients with coronary artery disease and left ventricular systolic dysfunction (ejection fraction <40%) in sinus rhythm with heart rate ≥60 beats/min.2 The subgroup analysis suggested that ivabradine improved outcomes in patients who had a heart rate ≥70 beats/min.3 In the SHIFT trial, symptomatic heart failure (HF) patients with left ventricular systolic dysfunction (ejection fraction ≤35%) had a higher baseline heart rate ≥70 beats/min and a greater heart rate reduction by ivabradine than in the BEAUTIFUL trial, and ivabradine significantly reduced cardiovascular death or hospital admission for worsening HF. In the placebo group, risk for the primary endpoint events increased by 16% with every 5-beats/min increase from baseline heart rate.4 In the subgroup analysis of the SHIFT trial, there were significant treatment effects only in patients with a baseline heart rate higher than the median 77 beats/min.5


Speaking about the existing relationship betwwen art exhibitions and documentation, we try to do the same but with another field of knowledge. The following thoughts have been suggested by the course "In the places of the 'widespread' city" with the subtitle "What to do? Ideas and tools to know and govern modifications".


One of the problems of the ceramic industry is the high level of finished product loss, due to ceramic processing, leading to cracks and materials out of conformity. In this way it is necessary to recycle these solid wastes in order to reduce the environment impact. In this work, the solid waste of two red ceramic industries were milled and incorporated to the formulation of the industry, leading also to an economic gain. Incorporation percentages varied from 10% to 30 wt %. Samples were processed by extrusion and sintered at 950 oC and 1000 oC. The results indicate that the addition led to an improvement of sample properties, due to the decrease of black core formation, producing samples with higher uniformity and lower porosity.


A singulating brush for a finger pickup seed meter comprising a flat carrier on which two sets of bristles are mounted. The flat carrier defines two mounting positions for the singulating brush. In its first mounting position the first set of bristles of the singulating brush contact the seed engaging spoons of the radially extending fingers for dislodging extraneous seed. In is second mounting position the second set of bristles of the singulating brush contact the seed engaging spoons of the radially extending fingers for dislodging extraneous seed. The first set of bristles is stiffer than the second set of bristles.


NPY is a 36‐amino acid peptide that plays a critical role in the regulation of energy homeostasis. In response to chronic environmental stress, NPY released by neurons innervating the fat promotes adipocyte proliferation and lipid storage via NPY receptor 2 (Y2). Y2 also stimulates aldosterone synthesis in the adrenal gland; however, little is known about its role in the regulation of aldosterone secretion in adipose tissue. We have previously shown that Maternal Separation and Early Weaning (MSEW), a mouse model of early life stress, exacerbates high fat diet (HF)‐induced adiposity and increases circulating aldosterone in female mice but not in males. Thus, the aim of this study was to investigate the effect of MSEW on chronic stress‐induced aldosterone release by adipose tissue with or without the deletion of Y2. In addition, we tested the capacity of adipose tissue conditioned media from these mice to modulate the endothelial function of aortic rings ex‐vivo. Y2‐WT and Y2‐KO pups were separated from the dam for 4 to 8 hours during postnatal days (PD) 2 to 16 and weaned on PD 17. Control mice remained undisturbed and were weaned on PD 21. At weaning, female mice were fed a HF (60% Kcal from fat) for 16 weeks. Following, a subset of mice were subjected to restraint stress (RS) for 6 more consecutive weeks and the other one was not disturbed (NORS). At the end of the experiment, mice were euthanized, and ~50 mg of fresh adipose tissue was incubated in DMEM + 2% fatty acid free BSA (1 hour, 37°C). Aldosterone concentration was measured in media explants by ELISA. Visceral adipose tissue‐derived aldosterone secretion was similar in WT MSEW and control explants from NORS mice (3.22±0.21 vs 3.50±0.76 pg/mg tissue). RS increased aldosterone levels in the media explant from MSEW mice compared to controls (5.34±0.85 vs. 2.96±0.35 pg/mg tissue). The deletion of Y2 from adipose tissue depots attenuated the increased aldosterone release in response to RS in MSEW mice only (5.34±0.85 to 3.46±0.21 pg/mg tissue; p < 0.05). In additional studies, we used perivascular adipose tissue (PVAT) and mesenteric adipose tissue (MESAT) media explants from RS control and MSEW mice to test their effect on acetylcholine (Ach)‐dependent relaxation (pre‐constricted with ser 10−3 M, 3 ul). We performed relaxation dose‐response curves in thoracic aortic rings from healthy female mice (16‐week‐old fed a regular chow) before and after the incubation with fat explants. We found similar worsening of the baseline vascular relaxation when we incubated rings with PVAT media from MSEW and controls (14.38±4.58 vs. 19.95±3.80 Delta % relaxation). However, rings incubated with MESAT from MSEW mice showed significant worsening of the vascular relaxation compared to controls (26.71±4.44 vs. 12.43±2.63 Delta % relaxation, p<0.05). Y2 deletion protected the vascular function in both groups. Taken together, female MSEW mice exposed to RS are prone to release aldosterone from adipose tissue, dependent upon Y2 signaling. Increased aldosterone release near vessels may explain impaired endothelial function, which could be prevented by targeting adipose tissue Y2.


Abstract Aim: Assessments of surgical workflow offer insight regarding procedure variability, case complexity and surgeon proficiency. We utilize an objective method to evaluate step-by-step workflow and step transitions during robotic proctectomy (RP). Methods: We annotated 31 RPs using a procedure-specific annotation card. Using Spearman's correlation, we measured strength of association of step time and step visit frequency with console time (CT) and total operative time (TOT). Results: Across 31 RPs, a mean (± standard deviation) of 49.0 (± 20.3) steps occurred per procedure. Mean CT and TOT were 213 (± 90) and 283 (± 108) minutes. Posterior mesorectal dissection required most visits (8.7 ± 5.0), while anastomosis required most time (18.0 [± 8.5] minutes). Inferior mesenteric vein (IMV) ligation required least visits (1.0 ± 0.0) and lowest duration (0.9 [± 0.5] minutes). Strong correlations were seen with CT and step times for IMV dissection and ligation (ρ = 0.60 for both), lateral-to-medial splenic flexure mobilization (SFM) (ρ = 0.63), left rectal dissection (ρ = 0.64) and mesorectal division (ρ = 0.71). CT correlated strongly with medial-to-lateral and supracolic SFM visit frequency (ρ = 0.75 and ρ = 0.65). There were strong correlations with TOT and initial exposure time (ρ = 0.60), as well as visit frequency for medial-to-lateral (ρ = 0.67) and supracolic SFM (ρ = 0.65). Descending colon mobilization was nodal , rectal mobilization convergent and rectal transection divergent . Conclusion: This study correlates individual surgical steps with CT and TOT through standardized annotation. It provides an objective approach to quantify workflow.


This paper describes a series of laboratory tests on single instrumented model piles embedded in calcareous sand undergoing lateral movement. Key parameters influencing the maximum bending moment in the pile for a constant soil density have been identified to be pile head fixity condition, the ratio of the depth of moving soil to the pile embedded length, and pile diameter and stiffness. Normalized expressions for maximum bending moment are also presented. The agreement between the experimental results and the theoretical predictions by an existing boundary element program is shown to be reasonably good.


As you may know, due to wide range of oil, gas and petrochemical industries, application of cable in these industries is inevitable. Normal cables with normal PVC and PE insulations are not recommended specially in places likely to have oil leakage, as they are not resistant to hydrocarbons. So Cavicel Cable Manufacturing Company offers different solutions for such applications as follow: Oil Resistant PVC: This material is very economic and by adding chemical additives we can get to a new compound more resistant to oil compared to normal PVC. Lead Sheath: This layer is one of the oldest methods of cable reinforcement against chemical materials specially oil, which has many advantages and disadvantages. Among its advantages is strong resistance to hydrocarbons and disadvantages are as follow: 1 Environment pollution


Sing to God a new song! Sing to God, all the earth! Shiru L'Adonai shir chadash! Shiru L'Adonai kol ha'aretz! If this time of year had a soundtrack, it would definitely be right out of this Psalm! Psalm 96, recited often in prayers, begins with these rousing lyrics calling us, and all those around us, to pursue newness: perhaps a new way of life or newness in the way we appreciate it. Isn't this exactly the feeling we have at this season of the New Year? 5777 is here! Rosh Hashanah brings with it the hopes and promises of a brighter future as we turn to make amends for our shortcomings from the past year and vow to hold ourselves to our best in the year to come. This is a great time to check in with yourself and ask yourself those important existential questions: What kind of life have I been leading this past year? What do I want the year to come to look like? How can I best express who I am at my core? How can I connect with others in a way that is truly sacred and meaningful? How can I make a positive difference, big or small, in the world around me? As you embark on this serious task, remember to be good to yourself. Focus on the future and what you would like to do in the year ahead. Look for new ways you'd like to express who you are as an infinitely


PURPOSE: A device and a method for improving hybrid automatic repeat request recombination gain in a broadband wireless communication system are provided to change an interference pattern per a frame by changing an initial value of a PN code generator and a permutator per the frame. CONSTITUTION: A seed information generator(115) generates an initial value changing a channel and an interference pattern of a subcarrier wave combined according to the hybrid automatic retransmission request into a frame unit in a data transmission process. A subcarrier allocator(106) allocates the subcarrier using the generated initial value. The seed information generator changes the channel and the interference pattern of the subcarrier into the frame unit within the range of the initial value allocated in a base station. The seed information generator changes one of the first initial value representing the initial value of the permutator and the second initial value for generating a PN code as the initial value for changing the channel and the interference pattern of the subcarrier into the frame unit.


Purpose – The purpose of this paper is to determine the effect of synbiotic combination of lactobacilli with konjac glucomannan hydrolysate (GMH) to reduce Streptococcus mutans growth in vitro with the intention of characterising its efficacy as a new approach for oral hygiene.Design/methodology/approach – Strains of Lactobacillus acidophilus and S. mutans were grown individually or in combination in modified Columbia base broth supplemented with 2 per cent GMH. Following incubation, the samples were plated on De Man, Rogosa and Sharpe and Columbia blood agar and growth of both strains was assessed.Findings – The probiotic bacteria L. acidophilus was able to "out grow" S. mutans in the presence of konjac glucomannan in the mixed cultures.Originality/value – The results indicate that consumption of prebiotic and probiotic combinations may play a role as potential prophylactic or therapeutic agents for reducing the presence of organisms in the mouth associated with tooth decay. In order to confirm a benefic...


donor. In total, these covariates explained 41% of the variability in CL. No comedications or time after transplantation were associated with Tac PK. CONCLUSION: The population PK of Tac during the first 6 weeks after renal transplantation can be adequately described using our model. The relative Tac starting dose should be higher in CYP3A5 expressers, in patients with a lower bodyweight and a lower hematocrit. In contrast, patients receiving a kidney from a living donor should receive a lower starting dose. By combining these parameters an individualized dosing regimen can be developed and possibly lead to improved patient outcome.


We propose a visco-plastic strain gradient plasticity theory for single crystals. The gradient enhancement is based on an equivalent plastic strain measure. Two physically equivalent variational settings for the problem are discussed: a direct formulation and an alternative version with an additional micromorphic-like field variable, which is coupled to the equivalent plastic strain by a Lagrange multiplier. The alternative formulation implies a significant reduction of nodal degrees of freedom. The local algorithm and element stiffness matrices of the finite-element discretization are discussed. Numerical examples illustrate the advantages of the alternative formulation in three-dimensional simulations of oligo-crystals. By means of the suggested formulation, complex boundary value problems of the proposed plastic strain gradient theory can be solved numerically very efficiently.


In this article,authors introduce research,design and application of the compound soil nail support technology in China,analyze its collapsing reasons,and discuss problems existing in study and application.


The following properties of the vapor condenser used in vacuum freezing dryer system that were interior sturcture, placed position and the vapor condensation characteristic were introduced. Secondly, the design method of the tube vapor condenser outside the dryer whose tubes were placed in rows was gaved. Finally we discussed the process and condition of icing or frosting in the condenser, and expound its advantage and shortcoming separately.


In this thesis an attempt is made to explain the decisive grounds on which the choices of education and work are made. The precise question at issue is; Why does one choose the industrial-technical ...