Although some tumor lysis syndrome (TLS) cases have been reported with patients with multiple myeloma (MM) taking monoclonal antibodies (mAbs), the association between TLS and mAbs remains mostly unknown. We aim to investigate the association between TLS and mAbs and describe clinical features. We conducted a disproportionality analysis to investigate the link between mAbs and TLS by excluding known confounders and compared with other anticancer drugs. The association between mAbs and TLS was evaluated using information component (IC). Drug–drug interaction signals were calculated based on the Ω shrinkage measure. Parametric distribution with the goodness‐of‐fit test was used for the reported time‐to‐onset analysis. From 2016 Q1, to 2022 Q4, a total of 274 TLS with mAbs were reported in the US Food and Drug Administration Adverse Event Reporting System (FAERS) database. There were 27% of patients with TLS with mAbs who died and 20.1% occurred a life‐threatening situation. Daratumumab, elotuzumab, and belantamab mafodotin presented a robust disproportionate signal of TLS after excluding known confounders (IC025 > 0). Daratumumab had the highest disproportionate signal of TLS among all anticancer drugs for MM. Reported time‐to‐onset analysis showed the median days for TLS with daratumumab, isatuximab, elotuzumab, and belantamab mafodotin were 1.5, 14.5, 5.5, and 5.5 days, respectively. The drug–drug interaction analysis showed the co‐administration of drugs known to increase urate, induce hyperkalemia, or hypocalcemia elevated the reporting frequency for TLS with mAbs (Ω025 > 0). Our postmarketing pharmacovigilance analysis detected the reporting association of TLS and mAbs in patients with MM. Additional studies with robust epidemiological study designs that can validate these findings are warranted.


Income inequality has increased in past decades. In some countries, top earners have captured a large share of the overall income gains, while for others income has raised only a little. There is growing consensus that assessments of human development should not focus solely on overall income growth, but also take into account income distribution. Some see poverty as the relevant concern while others are concerned with income inequality more generally. BRIICS in Going for Growth might have positive or negative side effects on income inequality. More broadly, in pursuing human development and redistribution strategies simultaneously, policy makers need to be aware of possible complementarities or trade-offs between the two objectives. This study will outline the adverse effect of income inequality on human development in India. And how this could be improved by effective policy for ensuring equal accessibility of education, health services and other basic facility which are essentials for a quality life to every citizen of India.


This study focused on the optimal conditions of protoplast preparation and regeneration of Penicillium sclerotiorum 2246,which could transform ginsenoside Rg1 into ginsenoside F1.The optimal conditions were as follows: the mycelia were cultured for 24 hours,and then they were zymolysed for 2 hours by enzyme mixture of 5 mg/mL lywallzyme,5 mg/mL cellulase,and 5 mg/mL snail enzyme at 31 ℃ when 0.8 mol/L KCl was used as osmotic pressure stabilizer.Then protoplasts were treated with ultraviolet ray and NTG together to get the high mutation percentage strains.Finally obtained a mutation strain(NU-1) with high transformation rate and the conversion rate with increment from 16.7% to 30.5%.


AbstractGlobal land-cover data are widely used in regional and global models because land cover influences land–atmosphere exchanges of water, energy, momentum, and carbon. Many models use data of maximum green vegetation fraction (MGVF) to describe vegetation abundance. MGVF products have been created in the past using different methods, but their validation with ground sites is difficult. Furthermore, uncertainty is introduced because many products use a single year of satellite data. In this study, a global 1-km MGVF product is developed on the basis of a "climatology" of data of Moderate Resolution Imaging Spectroradiometer (MODIS) normalized difference vegetation index and land-cover type, which removes biases associated with unusual greenness and inaccurate land-cover classification for individual years. MGVF shows maximum annual variability from 2001 to 2012 for intermediate values of average MGVF, and the standard deviation of MGVF normalized by its mean value decreases nearly monotonically as MGV...


Survey evidence has demonstrated that support for a united Ireland from Catholics in Northern Ireland is markedly declining. Simultaneously, electoral support for the secessionist Sinn Féin party has substantially risen in the region since 1998. Critics have attributed Sinn Féin's electoral growth to consociational power sharing, which they argue rewards ethnic hardline parties. At the same time, many of these critics predicted that consociationalism would exacerbate secessionist sentiment within nationalism, a prognostication now contradicted by survey data. In analysing this paradox, we argue that there is not a switching of identities—from Irish nationalism to UK unionism—but the repositioning of Irish nationalism from a secessionist movement to a sub-state nationalism mobilizing for more resources within devolution. In explaining this, we illuminate how consociationalism allied to devolution can, if the right endogenous and exogenous supporting factors are mobilized, lead to the repositioning of identities within a regional rather than zero-sum national context.


In moderately acidic water/ethanol solutions, 7-(naphthalen-2-ylmethyl)-5,6-dihydrobenzo[c]xanthen-12-ium perchlorate shows C–H proton acidity giving rise to an ethylenic base species, instead of the hydration products of the typical flavylium network of chemical reactions, hemiketal, cis-chalcone and trans-chalcone. The kinetics of this acid–base process is much slower, kobs(s−1) = 3.5 × 10−3 + 0.16[H+], than those commonly observed for O–H deprotonation. In the presence of the triblock copolymer Pluronic F-127, the ethylenic base is dramatically stabilized shifting the pKa from 1.35 (in ethanol : water (1 : 1) to −0.35. Taking profit from the well-described temperature dependence of this polymer, a phase transition thermochromic system was achieved. The system was cycled between 5 and 35 °C with negligible changes in absorbance after 20 cycles.


Triphenylphosphine (TPP) derivatives, which are catalysts of reactions with epoxy and phenol compounds, were investigated regarding the melting behavior and catalyst effect. The melting behavior was measured by differential scanning calorimetry (DSC), and the relationship of melting behavior (melting point and heat of fusion) and chemical structure were discussed using the heat of formation calculated by a semiempirical method. Two schemes are proposed for the reactions with epoxy and phenol compounds: a complex formation scheme, and an ionic scheme. The ionic scheme was the predominant route in the reactions with epoxy and phenol compounds in the bulk state at high temperature (180°C) on the basis of DSC measurements of the curing reaction and the semiempirical calculation of the heat of formation of products and partial charge of the phosphine group in the TPP derivatives. Consequently, the reaction rate of epoxy and phenol compounds decreased by introducing electron-withdrawing substituents such as chlorine in the basic catalyst. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 85: 2335–2341, 2002


Bogie is train's running gear and its safety performance affects operation comfort,the safety and reliability of trains. Bogie frame,as the skeleton,plays a pivotal role in the bogie system. For the current CRH bogie frames,frames are all steel welded structures,which usually induce some faults,like crack,lack of weld,irregular weld shape,etc. In this paper,based on T welds of CRH1 bogie frame weld assembly process,PCA dimension reduction processing algorithm was used to calculate and gain 'features weld'vector. The system used MATLAB GUI software to capture real- time image and extract the weld seam,which were then compared with 'features weld',to judge the rationality of the weld seam captured and gave alarm prompt by means of setting the range of threshold value. Through a large number of weld images tests,it proves that image recognition technology is proper and reasonable in the application of bogie frame welding quality detection.


Structural acoustics may be defined as a multidisciplinary coupled field of physics usually referring to the characterization of either (1) the sound power emitted by a vibrating structure subjected to external dynamic excitation or (2) the vibrational response of structures excited by incident sound fields or fluid excitation. The Structural Acoustics and Vibration (SAV) Technical Committee is a diverse group of scientists and engineers sharing a common interest and shared stewardship in the health and advancement of the SAV technical discipline. In addition to the fundamental scientific study of the underlying SAV physics which is important to all SAV practitioners, there is also interest on the practical real-world, application of the SAV science to predict, control, and potentially reduce the vibroacoustic response of given structural acoustic systems. This paper begins by providing a fundamental definition of the underlying physics governing the SAV technical discipline. The numerous categories and subdivisions within the general SAV area are then addressed, along with illustrations of the broad array of scientific and engineering real-world applications in the field. Following that, examples of interesting career options as well as exciting new research areas in SAV are presented. Finally, this paper concludes with information regarding the makeup, functioning, and administrative philosophy of the SAVTC.Structural acoustics may be defined as a multidisciplinary coupled field of physics usually referring to the characterization of either (1) the sound power emitted by a vibrating structure subjected to external dynamic excitation or (2) the vibrational response of structures excited by incident sound fields or fluid excitation. The Structural Acoustics and Vibration (SAV) Technical Committee is a diverse group of scientists and engineers sharing a common interest and shared stewardship in the health and advancement of the SAV technical discipline. In addition to the fundamental scientific study of the underlying SAV physics which is important to all SAV practitioners, there is also interest on the practical real-world, application of the SAV science to predict, control, and potentially reduce the vibroacoustic response of given structural acoustic systems. This paper begins by providing a fundamental definition of the underlying physics governing the SAV technical discipline. The numerous categories and s...


This tutorial is for those who like to know how object-oriented languages work under the hood, why some things are expensive while other things are cheap, and why language definitions include certa...


Using distilled water as washing agent, the process conditions for removal of hexavalent chromium from Chromite Ore Processing Residue (COPR) contaminated soils were discussed in the paper, including the solid-liquid ratio, cleaning time, temperature and oscillation frequency. The best parameters obtained by single-factor test and orthogonal test, using hexavalent chromium removal efficiency indicators as the evaluation of cleaning process conditions, optimization the optimum conditions of soil washing. The results showed that: when cleaning time, temperature, oscillation frequency, and solid-liquid ratio were selected for 105min, 50°C, 200r/min and 1:40 respectively, the experimental result is the best. In this condition, we can remove the hexavalent chromium from soil effectively. The results provide the reference for the hexavalent chromium contaminated soil washing remediation technology.


The fatigue failure is most critical factor in lifetime estimation of industrial elements. The failure of a device in fatigue is due to a crack growth becoming instable and leading to strength decreasing. Based on Paris equation and S‐N curves of WhOler, the probabilistic fatigue crack growth is studied where each parameter can be considered as random variable. A reliability analysis was developed here for plates under fatigue crack; the failure event taken can be expressed by many performance functions called limits states depending on possible failure modes. We study 3 limit states, the first is the reaching of a critical value of crack width acr, the second is the reaching of the capacity value of tenacity of materials KIC, the third is the reaching of a critical number of cycles of applied stresses Ncr. Between theses 3 modes, we choose the most critical one toward the reliability value. A model of crack growth with respect to time is chosen to evaluate the time‐reliability variation and hence to esti...


The world is increasingly aware that armed conflict and sexual violence against women and girls often go hand in hand . However, armed conflict also brings danger of sexual violence for men and boys. Male survivors of sexual violence are less likely than women and girls to disclose assaults (Callender and Dartnall 2011), with the result that such violence is "vastly under-represented" in official statistics (WHO 2002: 154). Nevertheless, sexual violence against men and boys—including rape, sexual torture and mutilation, castration, sexual humiliation, forced incest and forced rape, and sexual enslavement—is a pervasive feature of armed conflicts around the globe. It can emerge in any form of conflict—from interstate wars to civil wars to localised conflicts—and in any cultural context (Russell 2008).


An Archimedean spiral lattice with a radial distance exponent α, is locally approximated by linear lattices. If the angle parameter is badly approximable, the area of the Voronoi cell converges if it is properly normalized with α.


Football players experience impacts to the head, some of which cause mild traumatic brain injuries known as concussions. Players wear helmets to reduce injury risk, and this study compares two helmets to determine their effectiveness in reducing potential concussions. The helmets analyzed are a "classic" type made of large foam pad pieces, and a "new" type made of small honeycomb pads. Both helmets share the same external polycarbonate shell & padding materials. Three helmet to helmet collisions are studied: case one: "classic on classic," case two: "classic on new," & case three: "new on new." Using finite element analysis method, stresses and contact pressures are calculated. For three collisions with the same forces applied, a player in case one experiences 0.96 MPa contact pressure at the skull, while a player in case three experiences 0.87 MPa. In case two the player wearing the "new" helmet is exposed to 0.9 MPa at the skull, while the player wearing the "classic" is exposed to 0.95 MPa at the skull. It is concluded that if a player uses a "classic" instead of "new" helmet, pressure on the skull is reduced by 9.4%, reducing the risk of that player sustaining a concussion.© 2014 ASME


The tight-binding model for a chain, where the hopping constants follow a Fibonacci sequence, predicts multifractality in the spectrum and wavefunctions. Experimentally, we realize this model by chains of small dielectric resonators with high refractive index ($\epsilon_r \approx 45$) of cylindrical form that exhibit evanescent coupling. We show that the fractality of the measured local density of state (LDOS) is best understood when the sites are rearranged according to the similarities in their local surrounding, i.e., their conumbers. This allows us to deduce simple recursive construction schemes for the LDOS for the two cases of dominant strong and weak coupling, despite our limited resolution due to non-zero resonance width and size constraints. We measure the singularity spectrum and the fractal dimensions of the wavefunctions and find good agreement with theoretical predictions for the multifractality based on a perturbative description in the quasiperiodic limit.


Two aspects regarding the ruminant's contribution to global methane (CH4) emissions were investigated: (i) testing the accuracy of the Intergovernmental Panel on Climate Change default values for dairy cows fed different diet types and differing slurry storage temperatures; and (ii) providing carbon-isotope (C-isotope) signature data to contribute information on the characteristics of ruminant-derived CH4 as global source. The experimental diets, fed to 18 dairy cows, were separated into forage-only (hay, C3 plant) and forage-concentrate diets (barley, C3 plant; maize, C4 plant). Accumulated slurry was stored at either 14 or 27C. The hay diet had the highest CH4 conversion rate (Ym 7.9%). Negligible amounts of CH4 were emitted from slurries stored at low temperature. No diet effect was found at 27C (~33 L/kg volatile solids). The isotope ratios of enteric CH4 averaged 67.7‰ (C3 plants) and 57.4‰ (C4; maize). High temperature slurry storage resulted in different enrichment factors eCO2-CH4 for maize (33.2‰) and hay (35.9‰). Compared with the Intergovernmental Panel on Climate Change default values for Ym and slurry CH4 emission the results gained in the present experiment were higher and lower, respectively. Slurry-derived CH4 was less depleted in 13 C than


This study presents an examination of situations that drive preservice teachers to make new decisions in the teaching practice process and the criteria they use in evaluating the decisions they make. In the study, a basic qualitative research model was adopted, and the criterion sampling method was used to determine the study group. Ten preservice teachers studying in the final year of the classroom teaching programme constitute the participants of the study. A reflective evaluation form and semi-structured interview form were used in the data collection process of the study. The preservice teachers filled in the reflective evaluation form after each implementation process they carried out over a period of ten weeks. In addition, the semi-structured interviews based on the reflective evaluation forms were conducted with the participants in pairs every week. The research showed that there were 57 different situations that drove the candidates to make new decisions in the classroom. It was seen that the candidates used 14 criteria in evaluating their decisions. When these criteria were examined closely, it was observed that the participants evaluated their decisions mainly on the basis of teacher-oriented and teaching-oriented criteria. In teacher education, specialised situations that require prospective teachers to make decisions in the classroom environment should be focused on. Moreover, by creating opportunities for preservice teachers to evaluate their decisions, candidates should be directed towards being student-oriented and learning-oriented in evaluating their decisions.


The paper is devoted to three-point bending of an I-beam with include of transvers shear effect. Numerical calculations were conducted independently with the use of the SolidWorks system and the multi-purpose software package ANSYS The results of FEM study conducted with the use of two systems were compared and presented in tables and figures.


Multimedia network teaching system has been very popular in classroom theory teaching,but due to limits in space,multimedia network teaching system,except online virtual training,is seldom applied in the training room.After discussing the use of multimedia technology,network technology and storage technology,the paper,combining the characteristics of professional training room,designed a multimedia network teaching system integrated real-time recording and broadcasting and resource management of practical teaching,so as to achieve an organic integration of information technology and practical training.


Introduction: the booktrailer is becoming an important digital resource to promote reading among students and thus encourage reading. Within this panorama, future teachers must have an academic background not only in specific areas of didactics, but also in the field of technology in order to be able to use them; that is, it is important in the initial training of the teacher. Objective: to analyse the opportunities


Calls for increased regulation are sometimes made in response to what is dubbed an 'arms race' in elections – a cost explosion in electoral expenditure driven by the competitive dynamics of elections. In 2010, New South Wales (NSW) adopted the first comprehensive caps on electoral expenditure in Australia on this basis. This paper examines the evidence for a cost explosion over the course of three NSW elections (1999–2007). It finds a significant but unevenly distributed increase in electoral expenditure – over 3 per cent per annum over and above inflation and the growth in voter population. In terms of explaining this spending increase, it finds a close relationship between electoral expenditure and the availability of campaign funds but a less clear one between such expenditure and the 'winnability' of the elections. 由于选举中发生的"军备竞赛"——选举的你追我赶造成选举成本的暴增——人们呼吁加强管制。2010年,新南威尔士对选举开销出台了封顶的详细规定,在澳大利亚尚属首次。本文考察了新南威尔士三个选举过程(1999—2007)中成本激增的情况。作者发现选举开销重要但分布不规则的增长——高于通货膨胀及选民增长百分之三。如何解释选举开销的增长呢?作者发现选举开销与选举资金获得的难易程度关系密切,而与选举获胜机会的大小的关系模糊。


Experimental dipole and rotational strengths of the three optically active terpenes were compared to those obtained from the magnetic field perturbation (MFP) and vibronic coupling theory (VCT), and the results were analyzed in order to facilitate future extension of current vibrational circular dichroism (VCD) simulation techniques to bigger molecules. Experimental VCD patterns could be faithfully reproduced by both calculations, but the absolute VCD intensities are usually underestimated. The size of the basis set is the main limitation in both the MFP and VCT calculations. Harmonic frequencies and dipolar strengths obtained by Hartree−Fock and five density functional methods are compared to experiment for α-pinene. For borneol, a natural occurrence and spectral representation of its conformers are discussed on the basis of comparison of the theoretical and experimental frequencies and VCD and absorption intensities.


The general aim of this article is to develop an understanding of the historical and contemporary frames for professional socialisation through doctoral supervision. Supervision is a crucial component of doctoral education, in the reproduction of future researchers and a research competent labour force. Special attention is directed towards Swedish doctoral supervision policy. Sweden shares the characteristics of a social democratic type of welfare regime in which national politics takes a special responsibility for and interest in higher education including doctoral education. In government policy texts providing the basis for two major reforms of doctoral education, in 1969 and 1998, we map and analyse what is expressed about supervision and its context, and how this is expressed, paying attention to both similarities and differences. Drawing on a governance perspective, including a critical policy analysis, we discuss the findings in terms of frames for the professional socialisation of doctoral students. In both reforms, we recognise a dominant supervision ideal which emphasises efficiency, but it is complemented and partly challenged by very different ideals: in 1969 by an academic ideal and in 1998 by an ideal promoting good doctoral working conditions. Altogether, this implies a shift in the framing of professional socialisation from emphasising efficiency as a matter of compliance to efficiency as a matter of interaction and cooperation.


Thank you very much for downloading the international uranium market. As you may know, people have search hundreds times for their favorite readings like this the international uranium market, but end up in harmful downloads. Rather than enjoying a good book with a cup of tea in the afternoon, instead they juggled with some harmful bugs inside their desktop computer. the international uranium market is available in our book collection an online access to it is set as public so you can get it instantly. Our book servers hosts in multiple countries, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the the international uranium market is universally compatible with any devices to read.


Inever thought I would ever be attending a banquet on the balcony of a restaurant that looked out across the Yalujiang River, straight into the Democratic People's Republic of Korea (North Korea). There we were, a delegation from


The author thinks it is also necessary to promote the Olympic spirit for aged people's recreational activity.He advocates deepening the understanding of the Olympic spirit through the Olympic slogan,trying to make aged people's recreational activity as widespread,prosperous and strong as the Olympics and mobilizing,summoning and attracting more senior citizens to participate in the recreational activity.


In order to solve the shortage of the environmental stress data obtained from field-test in reliability test of equipment,environmental test,new product design as well as the revision of corresponding environmental standards,through technical demonstration and exploratory research,the flight test of airborne equipment was conducted for some military aircraft series.The typical environmental condition of airborne equipment was obtained.The combined environmental stress level of equipment cabin was grasped.Furthermore,the reliable testing data was offered to compile combined environmental stress test-profile for aircraft airborne equipment.It has established the foundation of environmental stress database construction for the military aircraft airborne equipment in China.


Th is article gives a brief overview of a number of key archaeological sites, where the stages Naqada IIIC and D, which historically correspond to Dynasties 1 and 2, are well represented and where they can be studied in well-defi ned sequences. It also examines certain artifact types as potential index fossils and identifi es those areas of evidence where promise is given for a more comprehensive relative chronology of this period. Importantly, this article also highlights problems with the current defi nition of sub-stages. Th e fact that the end of the period Naqada IIID has as yet not been successfully defi ned, especially as there is consistent evidence for a continuation of ceramic typologies into the material culture of the Old Kingdom, is of particular importance, raising signifi cant conceptual questions regarding the validity of the term Naqada Culture. correctement


The paper expounds the mining equipments in No.2 mining area of Jinchuan Group and their employment status quo and development trendency,and gives brief description on excavating process.It also proposes some specific measures for improving the mining equipments and system.


Along with many different definitions of archaeology, from the inception of the discipline to the present, it may be valid to assert that it is a kind of complex dialogue on heritage with the public of contemporary societies. In this dialogue, archaeologists have directly constructed social memories and modern identities, this being an exceptional responsibility, and have at the same time been susceptible to ethnocentric transfers of modern values and expectations into the images of the past. In this respect, it may well be said that the public is not only the most important consumer of cultural heritage, but also an active participant indirectly influencing the shaping of archaeological interpretations of the past. Thanks to the global trends in the discipline, but also due to the administrative decisions of the Ministry of Culture and Information, archaeology in Serbia is compelled to intensify contacts with the public and to make the results of our work more readily accessible and economically sustainable. The paper aims to offer a short overview of theoretical premises of various models of collaboration of archaeology and the public, to point to the advantages and shortcomings, as well as the consequences of these approaches, thus warning of the many potential problems stemming from the uncritical dissemination of information on the past and heritage to the general public.


Retinal vein occlusions are common retinal vascular disorders, often complicated by cystoid macular oedema (CMO). The present report describes morphological and functional changes associated with an intravitreal injection of triamcinolone acetonide (TA).

Patient 1 was a 75-year-old woman with CMO due to a macular branch vein occlusion 2 years previously. Visual acuity (VA) was reduced to 0.25. Preoperative optical coherence tomography (OCT) and fluorescein angiography (FA) showed a CMO with macular thickening to about 400 µm (Figs 1 and 2). Having given informed consent, the patient was treated with an intravitreal injection of 25 mg TA. Five weeks after the injection, the oedema had almost completely resolved and the retina had flattened to 210 µm with the foveal depression visible again (Fig. 3). Fluorescein angiography showed a pronounced reduction in fluorescein leakage (Fig. 4) and VA had increased to 0.5.

Figure 1. Preoperative foveal OCT shows cystoid macular oedema and retinal thickening.

Figure 2. Preoperative late phase FA shows fluorescein leakage and the presence of a large foveal cystoid space.

Figure 3. An OCT image of the fovea 5 weeks after intravitreal injection of TA shows an almost complete resolution of the CMO.

Figure 4. Late phase FA shows a markedly reduced extravasation and absence of cystoid spaces 5 weeks after treatment.

Patient 2 was a 71-year-old man who had experienced a central retinal vein occlusion 8 months previously. Optical coherence tomography and FA showed an extensive CMO (Figs 5 and 6). Visual acuity was reduced to 0.4. Five weeks after an injection of 25 mg TA, foveal thickness had decreased from more than 600 µm preoperatively to 200 µm, and the fovea showed an almost normal central depression (Fig. 7). Fluorescein leakage was also markedly reduced (Fig. 8). Visual acuity increased to 0.5.

Figure 5. An OCT image of the fovea prior to the intravitreal injection of TA shows marked CMO and retinal thickening.

Figure 6. Preoperative late phase FA shows pronounced fluorescein extravasation and CMO.

Figure 7. An OCT image of the fovea 5 weeks after injection of TA shows a marked reduction of CMO and a decrease in retinal thickness.

Figure 8. Reduced extravasation 5 weeks after injection of intravitreal TA.

For many patients who suffer cystoid macular oedema after central or branch retinal vein occlusion, and who are either not eligible for or are resistant to laser coagulation, no satisfactory treatment options are yet available. During the last 2 years the intravitreal use of triamcinolone acetonide for various forms of macular oedema has been reported increasingly (Antcliff et al. 2001; Jonas & Sofker 2001; Jonas et al. 2001; Greenberg et al. 2002). The present report shows that intravitreal TA, without additional laser coagulation of the retina, can be associated with a decrease in or resolution of CMO, a reduction of foveal thickening by more than 50%, and a corresponding increase in central visual acuity.


The design of a Cyber-Physical System (CPS) is defined as a complex activity, being composed of a set of design phases devoted to model application characteristics. In this sense, detailing the phase characteristics is required in order to help the design teams during the project design, and to aim the support of the correct application characteristics representation. However, despite some of these phases, such as the control systems design, being discussed at length by the engineering community, other phases have less detailed studies, i.e., the design activities that compose these phases are not so well documented. In these sense, it is required more experience from the design teams to perform activities such as, the sensing and actuation subsystems representation, and the integration of formal verification methods on the design process, among others. Despite the lack of information related to them, these phases are essential to the CPS design, by the fact that they support application characteristics representation and the properties validation, as well as, they also provide the integration between designed system and their environment. Regarding the CPS design process, different methods are available in the literature, aiming to guide the designers to perform the modeling tasks. However, these approaches do not provide enough information related to those described activities. In this context, this thesis proposes an integrated method applied to CPS design, more specifically devoted to the Unmanned Aerial Vehicles (UAV) design. That proposed method aims to integrate different modeling processes such as functional, architectural, sensor and actuator integrations, and formal verification design processes. Based on the proposed activities this method aims to support the UAV embedded system design, and allow the integration between the embedded platform and the set of system devices. The Model Driven Engineering (MDE) is used as basis to the proposed approach, and aims to support the automated model generation based on the application characteristics. It is intended to ensure the maintainability of the system information over all the design steps and provide the property evaluation and validation, considering the model transformation principles. Two different tools are designed with the proposed method, the ECPSModeling and the ECPSVerifier, for supporting the design activities. The ECPSModeling provides the transformation process from functional model to architectural model, in order to integrate sensor and actuator characteristics. On the other hand, the ECPSVerifier provides the CPS behavior representation, based on the architectural model, by using timed automatas, which allows the formal verification evaluation by performing model checking. The proposed method and the designed tools are applied on the project of a tilt-rotor UAV design. The details of the method proposed in this thesis are demonstrated by performing the UAV project, described as a case study.


Four thousand years of practice and research in grafting woody plants have not provided significant answers to questions about the causes of graft incompatibility nor allowed valid predictions to be made regarding potential incompatibilities between individual plants of most species of landscape trees. In this paper, the author briefly reviews some of the more recent research findings dealing with graft success and failure and discusses three areas of research that have heretofore not been adequately studied. These are (a) wound compartmentalization, (b) girdling, and (c) lignification.


-This article demonstrates that Zimbabwe experiences serious problems of state capture. State capture began to be an issue in 2017 when factionalism between Team Lacoste and Generation 40(G40) reached its climax. However, state capture became topical in Zimbabwe in October 2018 following Reserve Bank Governor's (RBZ) announcement of interventions through the 2018 mid–term monetary policy statement, particularly the 2% tax; which immediately triggered price increases and fuel crisis. The research question addressed in this article is: What is state capture and how is it manifested in Zimbabwe? Firstly, it systematically unpacks the phenomenon as a type of businessstate relationship distinct from influence and corruption and outlines its types, features and essence. Secondly, the article explores state capture in contemporary Zimbabwefocusing on the mining, banking, energy (fuel), agricultural sectors, government ministries (legislature, state media and judiciary), the security sector and Zimbabwe Anti-Corruption Commission. The methodology and theoretical framework adopted in this study involves qualitative political economy approach. A combination of current research reports, analysis of newspaper articles and social media to illuminate the phenomenon and its manifestations. The article contributes to existing knowledge by not only clarifying a concept conflated with corruption but also analyzing the manifestations of state capture in Zimbabwe.


We have used density functional theory (DFT) with dispersion correction to investigate the adsorption and first dissociation step of hydrazine on Fe3Ni(111), FeNi(111), and FeNi3(111) surfaces. The calculations have shown that the FeNi3(111) surface offers the strongest binding of molecular hydrazine adsorbed on the top of an iron atom, whereas the strongest adsorption of NH2 fragment bridging between iron atoms is obtained on the Fe3Ni(111) surface; both molecular hydrazine and the NH2 fragment can be adsorbed strongly on the FeNi(111) surface.The first dissociation step of hydrazine on the FeNi(111) surface is found to be exothermic by −1.19 eV and presents an activation energy barrier of only 0.15 eV. A similar energy barrier is found on the Fe3Ni(111) surface, but a higher reaction energy of −1.47 eV is released on this surface. Furthermore, the electronic structures of the molecular and dissociative adsorptions are discussed, which is intended to shed some light on the binding nature of the adsorptio...


As Homer told us long ago, violence visibly bathed the lives and imaginations of citizens in classical Greece. My onetime collaborator, the irrepressibly witty political scientist Samuel Finer, phrased it this way: "Competitive, acquisitive, envious, violent, quarrelsome, greedy, quick, intelligent, ingenious – the Greeks had all the defects of their qualities. They were troublesome subjects, fractious citizens, and arrogant and exacting masters" (Finer 1997, I: 326). Among other forms of violence, the region's city-states warred repeatedly against one another. In 431 BCE, nevertheless, a delegation went from Sparta to Athens in the name of peace. All the Athenians needed to do to avoid war, the Spartan delegates declared, was to stop interfering militarily and economically with Sparta's allies in the region. Athens' citizens held a general assembly to debate their response to Sparta's challenge. Advocates both of immediate war and of peacemaking concessions spoke to the assembly. But Pericles, son of Xanthippus, carried the day. Pericles (rightly thinking that in case of war the Spartans would invade Athenian territory by land) recommended preparation for a naval war and reinforcement of the city's defenses, but no actual military action until and unless the Spartans attacked.


Visual cortex in the nonhuman primate (NHP) consists of a hierarchy of interconnected representations of the visual field arranged in parallel pathways. Knowledge of human visual cortex has been inferred from lesion and electrophysiological studies of the NHP and accidental pathology in human subjects. Recently, the functional imaging techniques of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) have for the first time provided a direct demonstration of functional specialization within human visual cortex. This article reviews NHP research and lesion studies in humans, which have suggested a segregation of visual information in the cortex for perception (areas V1, V2, V3) and the interpretation of form (areas V3, V4), color (area V4), and motion (area V5). The applications of functional imaging to support these data and, in some cases, verify the respective deficits associated with damage to these visual areas, such as visual field defects, akinetopsia (failure to appreciate motion), achromatopsia (failure to appreciate colors), and prosopagnosia (inability to recognize familiar faces), are detailed. In particular, several clinical settings in which PET and SPECT may be employed to evaluate visual cortex are discussed.


FIELD: production of adsorbing articles. SUBSTANCE: adsorbing article has first substantially liquid permeable surface layer, substantially liquid impermeable protective layer, and adsorbing body therebetween. Adsorbing article has substantially cone-shaped cavities which are continued through at least part of adsorbing body. Cavities have tip and base. Tip is oriented toward liquid permeable surface layer or is located within the latter, and base is oriented away from liquid permeable surface layer. Method for manufacturing of adsorbing article with cone-shaped cavities is also described in Specification. Method allows completely breathing adsorbing article to be manufactured by said method. EFFECT: increased efficiency and improved adsorbing capabilities of adsorbing articles. 25 cl, 3 dwg, 1 ex


Abstract Exploring the evaluation of the teaching quality of colleges and universities for applied talent cultivation in the context of big data is to be able better to improve the teaching level of colleges and universities. In this paper, the multi-indicator evaluation method is explained, and the commonly used teaching quality evaluation methods, i.e. hierarchical analysis, entropy weight method and gray correlation analysis, are cited. The basic principle of the hierarchical analysis method is given, the initial weight calculation steps of AHP method are illustrated, and the initial weights of AHP method are combined and solved using the entropy weight method. The evaluation principle of the gray correlation analysis method is given, and the combined weights of the AHP-EWM evaluation are illustrated using the gray correlation analysis method. Finally, universities' teaching quality evaluation indexes for applied talent cultivation were constructed using the AHPEWM evaluation method, and the indexes were mined and analyzed respectively. From the indicators of theoretical literacy and professional research ability, the overall evaluation of the teaching quality of colleges and universities is 92.77% above the C grade. From the indicators of innovation practice and moral quality, the percentages of students' evaluation of teaching quality in colleges and universities with A, B, C and D grades are 49.02%, 28.6%, 5.12% and 7.25%, respectively. This shows that the evaluation of teaching quality in colleges and universities is multifaceted, and colleges and universities can improve their teaching level according to different evaluation factors.


Objective To explore the perioperative nursing of knee arthroscopy assisted anterior cruciate ligament reconstruction.Methods 80 patients with knee arthroscopy assisted anterior cruciate ligament reconstruction recevied perioperative nursing.Results All 80 patients got successful operations,and satisfied with the postoperative recovery of joint function.Conclusion Sufficient preoperative preparation and experienced nursing cooperative techniques are the key to successful operation and the guarantee for postoperative rehabilitation.


A new procedure for cyclohexenone annelation has been developed. Thus, alkylation of 4-isopropylcyclohexanone with allyl bromide gives, over several steps, ketone 8. Exposure to (trimethylsilyl)diazomethane and MeLi smoothly cyclized 8 to the cyclopentene 9 by insertion of the intermediate alkylidene carbene into the unactivated methylene CH. On debenzylation, ozonolysis, and subsequent aldol condensation, 9 is transformed into oxo-T-cadinol (1).


Power quality has become an important research field due to two factors: the growing competitiveness in power system and the increase of non-linear loads in the system, serving as a cause of voltage distortion in distribution systems. In this sense, this work has the aim of improve power quality by indentifying power distribution transformers which have voltage total harmonic distortion (VTHD) above the brazilian limits. It was used a database with monitored data and electrical characteristics obtained during a monitoring campaign in Energy Company at Paraná (COPEL). This information was used to classify the transformers by VTHD, according to a physical division in 5 regions in Paraná State. The VTHD limit used was approved by Power System National Operator (ONS) at Brazil and it has the value of 6% for Power Systems with voltage under 69kV. It was applied the Rough Sets Theory (RST), developed by Zdzislaw Pawlak in the 80's, which has increasing usage to Power Systems analysis in classification problems and removal of irrelevant information in databases. The application of RST was successful and it allows the acquirement of rules which makes possible the estimation of VTHD in another power distribution transformers. So, with this VTHD estimated it is possible to guide a monitoring campaign avoiding time and money losses. To validate the application of rough sets Theory the rules obtained were applied to the original database to assure the discernibility capability of created sets. The results were compared with other techniques such as quadratic scores and logistic regression, applied to the same problem, and RST had better classification capability. Key-words: Rough Sets. Power Quality. Voltage Total Harmonic Distortion. Classification. LISTA DE ILUSTRAÇÕES Figura 1 Exemplo de regiões positiva, de fronteira e negativa............................. 15 Figura 2 Definição das regiões e dos conjuntos de aproximação ........................ 16 Figura 3 – Sistema elétrico hipotético .................................................................... 17 Figura 4 Representação gráfica dos conjuntos redução e núcleo básico ............ 20 Figura 5 Representação da onda fundamental e da componente harmônica ...... 35 Figura 6 Onda fundamental somada à componente harmônica .......................... 35 Figura 7 Harmônica versus corrente harmônica .................................................. 36 Figura 8 – Período de monitoração e período de análise ...................................... 48 Figura 9 – Exemplo de DHTV – abaixo de 6% ....................................................... 49 Figura 10 – Exemplo de DHTV – acima de 6% ...................................................... 49 Figura 11 – Espectro da tensão no período de maior distorção – abaixo de 6% ... 51 Figura 12 – Espectro da tensão no período de maior distorção – acima de 6% .... 51 Figura 15 Importação do banco de dados ........................................................... 57 Figura 16 Geração dos redutos ........................................................................... 58 Figura 17 Geração de regras ............................................................................... 58 Figura 18 – Regras geradas................................................................................... 60 Figura 19 Resultado da aplicação das regras ...................................................... 61


The right of underaged patients to confidential health care should be considered an inalienable human right. Access to such care is also advisable according to contemporary medical knowledge. The aim of this study was to verify the extent this right is exercised in Poland and to examine social attitudes towards this issue.


Diagnosis of anal pyoderma and anal fistula by palpation is a common but extremely difficult method. We stud-ied the effectiveness of ultrasonic examination as a supplementary diagnostic modality by examining 50 cases of pyoderma and 100 cases of low intermuscular anal fistula to determine which of the two diagnostic methods ― palpation alone or ultrasound combining radial and transcutaneous linear echo ― is more consistent with the surgical findings. The diagnostic accuracy of palpation alone was 60 % for pyoderma and 86 % for anal fistula, which increased to 94 % and 99 % , respectively, with ultrasonic diagnosis. Additionally, the transcutaneous linear probe can qualitatively di-agnose soft tissue tumors such as atheromas and lipomas. Preoperative ultrasound is thus an extremely effective sup-plemental diagnostic modality.


PZN-PZT/PI,PZN-PZT/PVDF 0-3 piezoelectric composites were fabricated using solution blended and hot pressing processes.The piezoelectric constant d_(33) and flexibility of the materials are excellent.The common character of 0-3 piezoelectric ceramic/polymer composites was discussed.The dependence of type and mass fraction of ceramic powder,type of polymer and poling parameters on the piezoelectric coefficient d_(33) of piezoelectric composites was investigated.Some methods to improve the piezoelectric property of this kind of material were approached.


Centralized planning in the field of natural resource management has exaggerated the administrative and fiscal problems burdening urban institutions in India since the colonial period. Focusing on an industrial city bordering the river Ganga in northern India, the discussion highlights a series of legal and legislative changes that have partially divested city institutions of the power to manage sewerage and water services. This divestment is examined by reviewing environmental law and Supreme Court orders, and analyzing the roles of various government agencies in pollution prevention projects. The analysis shows that, in the tussle between the judiciary and legislative-executive branches in the area of environmental protection, centralized resource management policies significantly marginalized urban institutions to maintain control over the administration of the environment.


With the development of Enterprise Decission Support, datawarehouse and relative technology such as OLAP,datamining has been got focused.This article gives a brief introduction of datawarehouse's architecture , shows several OLAP technology in detail, and brings out the difference between datawarehouse and datamart and several optimizing technology of OLAP.


The economists, who have consensus on the approach that the education has a strong effect on the acquisition capacity and economic growth, think people as human capital. This approach has increased investment in education. This increase in education has led discussion on the idea of equity. This idea which has a quite long development process, is defined as people have the same rights and freedom regardless of their social class and origin. This kind of idea covers both registering and completing higher education. But, it is seen in researches that social and economic status of individuals, and financial policies have an affect on taking the advantage of educational opportunities. The aim of this study is to create a technical framework for the financial policy of higher education that will serve for equity principle in Turkey. At the end of this study it is seen that people who belong to higher income groups benefit from spendings for higher education than people who belong to lower income groups, although they have on important ration in tax income, and this hasn't been change for the last thirty years.


Objective:To observe whether there is abnormal expression of tetrodotoxin-resistant (TTX-R)hNa v1.8 channel protein in demyelinated fibers of the affected nerves in patients with trigeminal neuralgia(TN), and to explore the relationship between ectopic discharges and TN.Methods: Six affected inferior alveolar nerves obtained from patients with idiopathic TN were studied. One great auricular nerve and one normal inferior alveolar nerve were used,which were obtained from patients undergoing combined radical neck dissection with glossectomy (negative control) and mandibulectomy (normal controls) . One rat spinal nerve was used as positive control. Immunohistochemical method and electron microscope were used to observe the expression of TTX-R hNa v1.8 channel protein in all groups. Results: Strong expression of hNa v1.8 channel protein was found in the demyelinated fibers of the affected nerves in patients with TN, weak expression in the neuraxon of rat spinal nerve,and none in the normal inferior alveolar nerve and the great auricular nerve. Conclusion: Abnormal expression of hNa v1.8 channel protein in the demyelinated fibers in patients with TN may play an important role in the pathogenesis of TN.


Object is to provide a force for connecting fiber core conductor (21) connected to the wire means (1, 10), the wire connecting means (1,10) controlled by acting on the shearing direction of the fiber core conductor to improve reliability of electrical connection. A plurality of electrically conductive fiber core wire is formed by metal plating a surface of the conductive fiber, the fiber for connecting the core conductor constituted by twisting a plurality of the electrically conductive fiber core wire (21) of the wire connecting means (1,10) comprising: rivet (3), the rivet (3) pin having a rod-shaped portion (5) to be mounted and the head portion (6) of the pin portion at the end of the fiber core conductor (21) (5) extending outwardly; and a plate-shaped terminal (4), the plate-shaped terminal (4) having an opening (8) and the overlapped portion (9), the pin portion (5) is inserted through the opening (8), and the rivet (3) to the opening (8 ) connected to the head (6) superimposed on the overlapped portion (9). Fiber core conductor (21) is clamped between the overlapping portions (9) of the head (6) and the terminal (4) in order to make the fiber core conductor (21) and the terminal (4) is electrically connected.


SIP(Session Initiation Protocol)is one of the core controlling protocol for next generation network(NGN).This article introduces the structual design of the experiment model of embeded internet visual phone based on SIP.


This article presents a study devoted to the emerging method of synthesized optimal control. This is a new type of control based on changing the position of a stable equilibrium point. The object stabilization system forces the object to move towards the equilibrium point, and by changing its position over time, it is possible to bring the object to the desired terminal state with the optimal value of the quality criterion. The implementation of such control requires the construction of two control contours. The first contour ensures the stability of the control object relative to some point in the state space. Methods of symbolic regression are applied for numerical synthesis of a stabilization system. The second contour provides optimal control of the stable equilibrium point position. The present paper provides a study of various approaches to find the optimal location of equilibrium points. A new problem statement with the search of function for optimal location of the equilibrium points in the second stage of the synthesized optimal control approach is formulated. Symbolic regression methods of solving the stated problem are discussed. In the presented numerical example, a piece-wise linear function is applied to approximate the location of equilibrium points.


The invention discloses a nano-loading zero-valent-iron-based PVDF (Polyvinylidene Fluoride) compound material as well as a preparation method and application thereof. The main preparation method comprises the following steps of: (1) pretreating a PVDF microfiltration membrane; (2) functioning the PVDF filter membrane by taking acrylic acid (AA) as a functional monomer; (3) respectively immersing the functioned PVDF filter membrane into sodium salt and soluble iron salt solutions for ion exchange, loading iron ions on the functioned PVDF filter membrane; and (4) immersing the PVDF filter membrane into a borohydride salt solution so as to prepare the nano-loading zero-valent-iron-based PVDF compound material under the strong reduction action. By respectively repairing simulative dyeing wastewater, heavy metal wastewater and anionic organic wastewater at the room temperature through using the reduction function of the material, the nano-loading zero-valent-iron-based PVDF compound material as well as the preparation method and the application thereof disclosed by the invention are conveniently and simply operated and easily recycled, have the advantages of low cost and good dispersity of nano iron particles, and are capable of reducing ecological risks caused by that the nano iron particles flow into water so as to improve the service cycle of the compound material. The nano-loading zero-valent-iron-based PVDF compound material can be regarded as an environment-friendly environment restoration material.


The events related to climate change are recently challenging the Slovenian urban planning. One of them are the floods in urbanised areas that call for a radically new approaches to how the urban built structure is organised and managed. The continental (and largest) part of Slovenia has a subalpine climate which has been traditionally characterised by a moderate precipitation throughout the year. This is now being changed as the larger amounts of water fall on the ground in a shorter period. As the current urban structure is not shaped in accordance with these new circumstances, parts of the cities are getting flooded more often. Some mitigation measures have been implemented, however to address the issue comprehensively new urban planning approaches are needed too. The paper will present one of the tools that has been developed within the endeavours of the national Ministry of Spatial Planning to reform the urban planning system to better reflect the changes posed by the climate change. It is related to the urban design criteria for building plots planning. To allow the rainfall to penetrate the soil as soon as the precipitation reaches the ground, new measures in organisation of the building plots will be provided. The current system defines the percentage of the built-up area within the plot but does not consider the permitted percentage of the paved open spaces (which do not allow the water to penetrate into the grounds), therefor it will be supplemented by the new measures based on the ability of the plots to allow the penetration of the water. The paper firstly presents the current system of building plots regulation within the Slovenian planning system. It then reports the results of the extensive analyses that focused on the existing characteristics of building plots for different building typologies across the country (housing, production, trade, public services) with the aim to map the state of the art in terms of the potential of the existing building plots to allow the water to flow into the grounds. The third part explains the methodological framework for the new approach to the building plots regulation. The last part presents the newly proposed approach and relates it to other urban design tools that need to support the implementation in practice. The concluding section relates the lessons learnt in Slovenian case to the similar situations elsewhere and stress the responsibilities that the urban planning and design have in providing future urban environments that will ensure the environmentally just living conditions for all.


We present two approaches to creating geodemographic classifications using deep neural networks. Both deep neural networks are based on autoencoders, which allow automating dimensionality reduction before clustering. The second approach also introduces the idea of geographic convolution in neural networks, which aims to mirror in the geographical domain the approach of graphical convolution, which has revolutionised image processes in the past decade. To test our approaches, we created a geodemographic classification based on the United Kingdom Census 2011 for the county of Leicestershire and compared it to the official 2011 Output Area Classification. Our results show that the two deep neural networks are successful in creating classifications which are statistically similar to the official classification and demonstrate high cluster homogeneity.


An electrostatic voltmeter which is of fairly simple construction is described. It has a scale which is more nearly linear than is usually found with such instruments, and which can be applied to several different voltage ranges.


ABSTRACT ‐ Fifteen psychiatric patients participated in a double‐blind cross‐over study of the effect of sodium valproate (a GABA mimetic drug), biperiden (an anticholinergic drug) and placebo in neuroleptic‐induced akathisia, parkinsonism and hyperkinetic movements. All patients had subjective and objective signs of akathisia, 11 had parkinsonism and 11 hyperkinesia, eight of which were tardive dyskinesia (TD) and three initial hyperkinesia. After a pretreatment washout period of 2 weeks, during which anticholinergic drugs, if any, were replaced by placebo, the patients were treated in three randomized periods of 4 weeks with sodium vaiproate, biperiden and placebo. Compared to placebo, sodium vaiproate (900–2400 mg/day, median 1700) had no significant effect on akathisia and parkinsonism, although akathisia was reduced in four patients (unchanged in 10 and increased in one) and parkinsonism was induced or aggravated in seven patients (unchanged in five and reduced in three). Sodium valproate, however, reduced hyperkinesia score (TD + initial hyperkinesia) from 1.6 to 1.2 (P < 0.05). Biperiden (6–18 mg/day, median 12) significantly reduced akathisia score from 1.4 to 0.6 (P < 0.01) and parkinsonism from 2.0 to 0.6 (P < 0.01), and increased TD score from 2.1 to 3.9 (P < 0.05). None of the drugs induced significant side effects. It is concluded that 1) sodium valproate has no significant effect on akathisia, but a slight beneficial effect in hyperkinetic movements, both TD and initial hyperkinesia, 2) sodium valproate may aggravate parkinsonism without necessarily aggravating akathisia, and 3) anticholinergic drugs like biperiden appear still to be the best treatment for akathisia.


In forensic autopsy case, the forensic pathologist may require a complete toxicological investigation for drugs, pesticides and other chemical compounds. In India, this is usually carried out by Forensic Science Laboratories run by government under the Home ministiy. The samples have to be analyzed by the, forensic toxicologist. This article deals with the extraction, isolation and clean procedures for analysis of pesticides/insecticides and alkaloids. It attempts to simplify the standard procedures in a flow chart manner, which can be of handy reference for the forensic toxicologist.


A greater understanding of how blood behaves when ejected from a vessel under pressure will assist with interpretation of arterial bloodstain patterns and allow us to address questions such as; how far might blood be projected from an injury; how likely it is that an offender would be bloodstained; how much would clothing or covering of a wound reduce the extent of the blood projection?

We are using a medical training device consisting of a cardiovascular pump and vessel pads containing synthetic arteries ranging from 2 mm to 8 mm diameter and imbedded within synthetic human skin and tissue.

We will discuss our first steps in setting up this equipment to establish a reproducible and reliable mechanism to create arterial bloodstain patterns. We will also describe the results of our initial tests carried out using coloured water and progressing through to development of a synthetic blood substitute. We anticipate running trials using human blood in the near future and we hope to discuss the results of these trials at the conference.

We will also discuss how we are using the pump and "injured" vessels to create arterial bloodstain patterns to investigate a range of pattern features; maximal distances travelled by blood spots; extent of bloodstain patterns produced; size of blood spots; and pulsatile wave patterns. The effect of varying factors such as size of injury, artery diameter, covering of the wound, and the position of the vessel pad (horizontal or vertical) on the resulting patterns will then be assessed.


Torula is a form of yeast, producing lesions preferably in the central nervous system. These lesions macroscopically simulate tuberculosis, from which disease they must be differentiated as well as from lesions formed by coccidioides and blastomycetes. It is not my object in this paper to go deeply into the differential features of these three diseases but briefly to point out the main differences and then present a case of torula infection in a man admitted to the San Francisco Hospital, September, 1916. It is definitely agreed that coccidioidal granuloma and blastomycosis are two different diseases. Coccidioidal granuloma is a disease produced by an organism which sporulates but never buds in tissue. It varies greatly in size, having large forms up to 30 or 40 or even 80 microns in diameter producing many small ascospores which, in turn, escape from the capsule. It simulates tuberculosis in the type of its lesions


We report our recent progress in the experimental implementing of an all-optical 4He atomic magnetometer being free from the dead-zone effect. A liquid crystal is adopted to constitute a polarization rotator. The light linear polarization vector can be adjusted and ultimately kept perpendicular with respect to the varying ambient magnetic field direction. We then make some further investigations to enhance the magnetometer sensitivity through reducing the laser intensity noise and optimizing parameters like the laser beam size, the input laser power and the modulation depth. The magnetometer demonstrates an improved magnetic field sensitivity of about 300 fT/Hz1/2 for frequencies above 10 Hz.


In this paper, we consider examples of the Peirce decomposition of simple balanced generalized Jordan triple systems of second order associated with Lie algebras. By means of choice of a tripotent element for these triple systems, we can realize the decomposition without using the root systems of Lie algebras. with a triple system,which has a triple product's structure into the subspaoe oomponent $L of $L$ . And if $dimL _{-2}=dimL_{2}=1,\mathrm{i}\mathrm{t}$ is said to be a balanced triple system for $L _{1}$ , furthermore,a property of $0'$ -grading of Lie algebras is reduced from that property of triple systems equipped with 2nd order (to see , $[ \mathrm{K}1]-[\mathrm{K}5])$ . This is one of simple reasons for us to consider about the triple gystems.


Objective: To establish determination of quercetin in effective part of Mongolian compound senden-4.Methods:column was hypersil ODS 25μm(4.6mm×250μm).The mobile phase was methanol-0.7% phosphoric acid(40∶ 60),detection wavelength 371nm,flow rate of 1.0mL/min.Results:Quercetin with 0.0000976 ~ 0.000976mg range had good linearity,r=0.9999,average recovery was 100.94%,RSD=1.74%.Conclusion:This method is rapid,accurate,reproducible and can be used for determinaticn of quercetin in effective part of monglian compound senden-4.


Cultures of Helminthosporium maydis, race T, grown on modified Fries' medium under 1300 ft-c of continuous light produced at least 7 times more toxin than those grown in the dark. Thin-layer chromatography of the chloroform extracts of culture filtrates revealed that light has a general effect on metabolism of the fungus rather than a specific effect on toxin production. Light-grown cultures were found to be richer in chloroform-extractable metabolites including the toxin. The defined medium suggested by Karr et al. (5) was found to be unsuitable for high yields of toxin production.


Oral health is one of the significant determinants of general health, happiness and life quality. Dental caries, oro-dental trauma, periodontal disease and birth abnormalities including cleft lip and palate are among the reasons for tooth loss. High prevalence of tooth loss is the major cause of morbidity due to oral diseases in low and middle-income countries (WHO report,). Polymethyl-methacrylate (PMMA) bases are the preferred option for replacing missing teeth because of its biocompatibility, stability, easy handling, and low toxicity. Though PMMA is the most preferable material for denture preparation, lack of antimicrobial potential, thermal conductivity and radiopacity limits its diverse application. Seminal findings have shown, incorporation of certain nanoparticles may increase the antimicrobial potential, thermal conductivity and radiopacity of the PMMA. In the current review, we have elucidated light on the antimicrobial potential of PMMA based on the available information. We also focused on the current advancement and strategy regarding the improvement of antimicrobial potential of PMMA and other base materials. The information has been collected from published article available on PubMed up to 31 May 2022. The available studies supported that the antimicrobial property of PMMA can be improved by incorporation of nanoparticles such as graphene silver nanoparticles, TiO2, ZnO, SiO2/Ag These nanoparticles have been found to be effective against Staphylococcus aureus, Streptococcus mutans, Candida albicans, Escherichia coli, Pseudomonas fuorescense. In addition to nanoparticles, inert coating materials such as ammonium chitosan, sodium alginate, bioactive glass, chlorhexidine and organoselenium can be incorporated to enhance the antimicrobial properties of PMMA base denture material as well as inert coating material can be used to prevent the metal ion toxicity and a probable vehicle to leach the desired product at targeted site.


This writer became hypersensitive to an isocyanate about fifteen years ago. For many years this was the only chemical I was sensitive to. This hypersensitivity led to pancreatic insufficiency and food allergies of the masked or cyclic type. This was followed by a rapid accumulation of chemical sensitivities to aromatic materials derived from coniferous/petrochemical sources. Rendered unemployable by the above process, I have had the leisure to read widely in an effort to understand this process of destruction. Having been trained as an electrical engineer, I do not have the regimented mind set of one trained in medicine or biochemistry. As such, I have attacked the problem more from the point of view of a philosopher. My engineering training and 20 years of experience as a practicing engineer have given me a realistic appreciation of the types of processes that God allows. This, in addition to having my own body to observe and experiment with, with the analytic precision of an engineer, has resulted in the following perception of the processes involved. What follows is a top down analysis of what I have learned. This is the reverse of the order of discovery. I have recently observed that a reaction to exposure to isocyanate consists of two parts. The first part is the known process involving a bronchial spasm, broncharrea, running nose and occasionally ear blockage. This is a chemical specific reaction. The second part of the reaction I call a chemical non-specific reaction or "flush". This nonspecific reaction was first observed as the only reaction to an exposure to the diverse pollution of a Sears Roebuck store. This flush occurred with the proper (for me) time delay from exposure to reaction and contained none of the chemical specific symptoms associated with an isocyanate exposure. I then recognized that this flush always accompanied an isocyanate reaction but could stand alone and was, therefore, a separate phenomenon. The following is my analysis of this chemical non-specific reaction or flush. There is an enzyme found and generated throughout the body called Superoxide Dismutase (S.O.D.). This enzyme is found in three forms. These forms contain copper, zinc or manganese. This material is particularly effective in passivating free radicals. S.O.D. levels in lung tissue in people living in a "dirty" city like New York are elevated


Correction terms are grounded, base maintenance of the system is developed psychological-pedagogical accompaniments of sporting activity of invalids. On the problems of sport of invalids over 100 literary sources are analysed. It is set that the observance of correction terms foresees the high degree of individualization of planning and realization of the special measures of psychological preparation. It is marked that correction terms must answer the structure of competition activity of sportsmen. An accent is done on the necessity of clear regulation and coordination of professional actions of specialists during work with sportsmen.


Microbial Diversity
Astonishing levels of fine-scale microbial diversity have been uncovered by DNA sequencing of natural populations. How this diversity is shaped and maintained and what its environmental or clinical implications might be is unclear. Using custom-made advanced statistical methods, Rosen et al. analyzed the evolutionary structure of a photosynthetic bacterium that grows in the hot springs of Yellowstone Park (see the Perspective by Desai and Walczak). The populations behaved neither as clones nor "ecotypes" but more like sexual organisms. These cyanobacteria have high recombination rates that maintain diversity and prevent selective sweeps that would otherwise reduce diversity.

Science , this issue p. [1019][1]; see also p. [977][2]

 [1]: /lookup/doi/10.1126/science.aaa4456
 [2]: /lookup/doi/10.1126/science.aab3957


The first article in this series, "Exact Confidence Limits for Process Capabilities," showed how the bivariate noncentral t-distribution provides a confidence interval for Cpk. This method provides exact confidence interval for Cpk.Measurement..


Several contemporary approaches seek to ar- ticulate new material agencies and transcorporeal rela- tions of the body. Since materialist feminism, feminism as the body, transcorporeal feminism or post-human femi- nism, they all intersect in a nodal sense and articulat- ing new semiotics of corporeality. In this work, it will be analysed how this type of redefinitions and intersections of the idea of body reconfigure many ethical and feminist dilemmas.


Abstract The purpose of this study was to directly observe and investigate the factors that support or hinder the implementation of an integrated approach to formative assessment and to understand how the implementation of formative assessment strategies interact. The authors present findings from a collective case study that included the observation of six teachers (three mathematics and three English language arts) who were purposefully sampled from a large, public, suburban high school in the northeast United States. The analysis of the case studies resulted in the identification of different patterns in teachers' formative assessment practice. These patterns illustrate how the complex interaction between formative assessment practices can either support or hinder the implementation of an integrated approach to formative assessment and suggests classroom observations as a potential mechanism for identifying challenges and informing just-in-time professional development.


In this study, the filtering characteristics of sulfur gases were investigated from a number of respects. For the purpose of this study, a standard gas containing a single oxidized S () and five reduced S compounds (RSCs) including , , DMS, , and DMDS was prepared. After flowing this standard gas through a glass fiber filter, its removal efficiencies were examined by comparing the concentrations between prior to and after its passage. The results indicated that almost complete removal of was achieved by this filtering, while the patterns for RSCs were distinguished by such factors as molecular weight or reactivity. It was found that about 60% of the most reactive RSC, was removed by filter, while the heavy RSC generally showed removal rate of about 5% or less.


In order to understand the changes of pigment content in Narcissus Tazetta flower at flowering phase,the contents of carotenoids and flavonoids in perianth and corona of JINZHANYINTAI and YELLOWFLOWERⅡ at flowering phase were tested by high performance liquid chromatography(HPLC).The results showed that there were a large number of various pigmentations accumulated in perianth and corona of Narcissus Tazetta,and rutin and phytoxanthin were the main pigmentations in YELLOWFLOWERⅡflowers,while rutin,naringin,ferulic acid and phytoxanthin were the main pigmentations in JINZHANYINTAI flowers.The dynamic trends of rutin,naringin and ferulic acid contents in the two varieties above were consistent at flowering phase: the contents in perianth and corona were the highest at flower budding period,were decreased somewhat at early flowering stage and full-bloom stage,and further increased at decline stage.But the phytoxanthin content change was not the same.Analysis of t-test indicated that there was a significant difference in the contents of rutin,naringin,ferulic acid and phytoxanthin between the varieties,respectively,and there was a significant difference in phytoxanthin and ferulic acid contents between perianth and corona in the same variety,respectively,but not significant difference for rutin and naringin contents,respectively.


The challenging retail environment requires a need to manage shopping malls effectively to understand the attributes that attract shopping mall visitors to visit shopping malls. The purpose of the study aimed to determine shopping mall visitors' perceptions or ratings towards shopping mall attributes they consider when choosing which shopping mall to visit. A quantitative approach was followed to realize research objective using interviewer-administered questionnaires for data collection. The data were collected at shopping centre in the capital city of South Africa, City of Tshwane. A descriptive analysis method was used to analyze the quantitative data. The findings of the study revealed that the shopping mall visitors' ranked adequate parking availability high. This study contributes to the current literature and provides valuable information to South African retailers and shopping mall developers, with regard to marketing communications and marketing strategies that aim to attract shopping mall visitors. Suggestions for future research are provided.


A rat monoclonal antibody against the murine transferrin receptor has been identified. The receptor is a 95,000 molecular weight species that exists in the cell membrane as a disulphide‐bonded dimer. Whereas 29 of 29 murine hematopoietic tumor cell lines express detectable numbers of transferrin receptors, less than 1% of adult thymocytes or spleen cells and only 5% of bone marrow cells are positive. However, fetal liver and neonatal spleen contain substantial numbers of transferrin receptor‐positive cells. Induction of Friend cells in vitro with dimethyl‐sulphoxide leads to an overall increase in the expression of transferrin receptors on the cell surface. The anti‐transferin receptor antibody we have obtained partially blocks iron uptake from 59Fe‐transferrin by a variety of murine cell lines and inhibits the growth of a murine myeloma cell line in vitro.


Gluteal fibrosis is usually secondary to intramuscular injections and rarely can be idiopathic in nature. Clinically characterized by proximal muscle weakness and in advanced cases groove can be seen in gluteal regions. It can mimic with other conditions like muscular dystrophies and poliomyelitis. MRI is a very valuable tool in diagnosing this disorder and is also helpful to exclude other conditions.


Objective
To learn the clinical effect and adverse reaction of hydromorphone for continuous epidural analgesia after cesarean section, and to provide effective anesthesia method for clinical.

Methods
116 cases of cesarean section were randomly divided into observation group(65 cases) and control group(51 cases), continuous epidural analgesia was used in the two groups after operation.Among them, hydromorphone + ropivacaine was used for the observation group, morphine + ropivacaine was used for the control group.The analgesic effect and sedation degree of the two groups were evaluated. The adverse drug reactions were observed, and satisfaction of the patients after the operation was investigated.

Results
6, 9, 24 hours after operation, the VAS pain scores of the observation group were lower than those of the control group, the differences were statistically significant(t=3.236, 4.970, 2.547, all P 0.05). The difference of postoperative first exhaust time between the two groups was not statistically significant(t=0.730, P>0.05). The satisfaction degree of the observation group was significantly higher than that of the control group, the difference was statistically significant(t=2.301, P 0.05).

Conclusion
For continuous epidural analgesia after cesarean section, hydromorphone can effectively relieve the pain after operation, the safety of the process is high, and it has good clinical application value.

Key words:
Cesarean Section; Analgesia, Epidural; Hydromorphone; Morphine; Ropivacaine


Metal sulfide electrodes were compared to a conventional platinum (Pt) counter electrode (CE) in quantum-dot-sensitized solar cells (QDSSCs), in which they were used to improve the short circuit current, fill factor, and conversion efficiency (η). We deposited optimal-temperature-based nickel sulfide (NiS) thin films on a fluorine-doped tin oxide (FTO) substrate by a facile chemical bath deposition method and successfully employed them as a highly efficient CE for QDSSCs. The obtained NiS thin-film nanoparticles exhibit high electrocatalytic performance and fast mass transfer rates toward the polysulfide electrolyte. Under the illumination of one sun (100 mW cm–2), the QDSSC with a NiS CE produces a higher η of 3.30 %, which is much higher than that of a Pt CE (1.89 %). Cyclic voltammetry, electrochemical impedance spectroscopy, and Tafel polarization measurements were performed to investigate the electrocatalytic activity of the NiS CE toward polysulfide electrolyte.


We prove existence and uniqueness of the solution to a Cahn-Hilliard/ Allen-Cahn equation in dimension 1 to 3 subject to a multiplicative stochastic perturbation driven by space time white noise. This models absorption/desorption mechanisms in surface interface or on cluster interface morphology. Some regularity properties of the solution will also be described. This a joint work with D. Antonopoulou and G. Karali.


Jacinta Kelly warns that women who take on too many career, childcare and household
responsibilities are more likely to ignore the signals of impending cardiovascular events.


Objective: The study determines distribution and forms of expression of Carabelli's trait in contemporary Jat Sikhs. It also ascertains the dichotomous nature of this trait. Study design: The study was conducted on 200 maxillary first molars (male: female ratio 50:50). The trait was scored either as present or absent. When present it was again assessed and categorized. All data was subjected to either chi-square analysis or Student t -test evaluation when indicated. The significance was noted at the 5% level. Results: Prevalence of trait came out to be 78.5%. The trait absent/present exhibits bilateral development. Groove form was the most common (35%) while pit form was least prevalent (2.5%). Each first molar and its antimere exhibit no statistical difference in the exhibition of trait. A definite statistically significant sexual dimorphism ( P Conclusion: The difference in this study was statistically significant at the 5% level, which was consistent with the greater crown reduction usually found in females. The present quantitative study in an endogamous group is of clinical, anthropologic, and forensic value and provides phylogenetic and ontogenic insights regarding the trait.


Introduction: 'Asteroid Pairs' are those found to share almost identical orbital elements [1,2]. Backward dynamical calculations suggest each pair had a single progenitor that split in the last ~1 Myrs. Photometric observations of the pairs' size ratio and rotation periods [3,4] support models [5,6] suggesting that the cohesion-less structure of the progenitors could not withhold their fast spin, which lead to the fission of the asteroid into a pair. Models [e.g. 5,6,7] suggest that the rotational-fission process results in the exposure of material from below the progenitor surface – these materials may have never been exposed previously to the weathering conditions of space [8]. Therefore, newly formed pairs may present a "non-weathered", fresh spectrum for their surfaces [9]. Results: Here we report infrared spectroscopic observations of a sample of 13 asteroid pairs of the Ordinary Chondrite / S-complex type, performed with NASA's IRTF and Las Campanas' Magellan telescopes. We measured two parameters of the pairs' 1micron absorption band: the center and the width (band analysis formalism follows [10]) and compared these values to those of asteroids of the background population that were measured in the same manner. The spectra of the background asteroid population were taken from [11] and from the SMASS database [12] and were chosen to match the pairs' taxonomy (S-complex), range of absolute magnitude (Hv of 13 to 16; corresponding to a diameter of approximately 1.5 to 7.5 km assuming an albedo of 0.22±0.01; [13]) and an orbit within the main belt. The results show (Fig. 1) that the pairs' band parameters are distributed most similarly to those of fresh objects (Q-type) than of weathered asteroids (S-type). For both distributions in Figure 1, the Kolmogorov-Smirnov test rejects the null hypothesis that the pairs' distribution of band parameters is drawn from the same distribution of the background asteroid population at >99% confidence level. Conclusions: This result supports the notion that on average, the surfaces of asteroid pairs are less weathered than the background population. This linkage between asteroid pairs and fresh surfaces gives observational evidence that asteroid pairs are young objects as deduced from dynamical models, and that the fission processes that formed them includes the excavation and transportation of material on the entire asteroidal surface. This level of detail not yet treated in pair formation models, but should be considered in future work. Setting the band parameters with the pairs disruption age that is calculated by dynamical models, could constrain the timescale of space weathering on Ordinary Chondrite asteroids. References: [1] Vokrouhlický D. and Nesvorný D. (2008) AJ, 136, 280–290. [2] Pravec and Vokrouhlický (2009) Icarus, 204, 580-588. [3] Pravec P. et al. (2010) Nature, 466, 1085–1088. [4] Moskovitz N. (2012) Icarus, 221, 63-71. [5] Scheeres D. J. (2007) Icarus, 189, 370-385. [6] Jacobson S. A. and Scheeres D. J. (2011) Icarus, 214, 161-178. [7] Walsh K. J. et al. (2008) Nature, 454, 188-191. [8] Clark, B. E. et al. (2002) Asteroids III, 585-599. [9] Binzel R. P. et al. (1996) Science, 273, 946-948. [10] DeMeo F. (2013) Icarus, in press. [11] DeMeo F. et al. (2009) Icarus, 202, 160-180. [12] Binzel R.P. et al. (2004) Icarus, 170, 259-294. [13] Mainzer et al. (2011) AJ, 741, 90.


This study aimed to find the relationship between governance and economic growth in North African countries (Algeria, Tunisia, Morocco). Which relied on GDP data at constant prices of the US dollar as a dependent variable and measure of economic growth for the sample countries, and on some indicators of governance as independent variables using Panel- VECM, and the study has found a positive impact in the long run with regard to the indicators of governance studied on economic growth, where The study was based on the fact that economic growth increases and develops whenever the governance indicators improve, and in the end the research concluded that the studied governance indicators do not cause economic growth in the short term but only in the long term.


AbstractA consolidation analysis method for an earth-rockfill dam based on the coupling of physical state, stress deformation, and seepage was established. In this method, a permeability coefficient model considering physical state and shear stress level was introduced, and it was integrated with Biot's consolidation theory to simulate the coupling relationship. Taking the Nuozhadu high earth-rockfill dam as an example, a parameter back-analysis method using a neural network and evolutionary algorithm was applied to back-analyze the permeability coefficient model parameters of the core material based on observation data of pore water pressure in the dam. Then, consolidation numerical analyses were performed by using the back-analyzed parameters and the constant permeability measured in situ, respectively. The spatial and temporal distribution of pore water pressure calculated by the back-analyzed parameters coincided quite well with the monitoring data during construction and operation. However, the numer...


Aim To investigate the effect of resveratrol on alcoholic cardiomyopathy and the underlying molecular mechanisms. Methods Male Wistar rats were divided into three groups: control,alcoholic,and alcoholic plus resveratrol group,n=10 for each group.After the intervention for six months,the invasive cardiac function of the rats was measured by physiological recorder,the histological structure of heart was evaluated by HE staining,the expression and phosphorylation of AMP-activated protein kinase(AMPK) and endothelial nitric oxide synthase(eNOS) in myocardium were determined by western blot,and the nitric oxide(NO) level in myocardium was detected by nitrate reductase method. Results Alcoholic intake for six months caused a significant decline in cardiac function and an obvious damage in cardiac structure.Oral administration with resveratrol partially reversed alcoholic-induced cardiac damage.Alcoholic intake significantly decreased the phosphorylated level of AMPK and eNOS and consequently decreased the NO level in myocardium.Treatment with resveratrol remarkably attenuated alcoholic-induced decline in the phosphorylation of AMPK and eNOS and decrease in NO level. Conclusion Resveratrol activates AMPK/eNOS pathway,increases NO level,and consequently prevents alcoholic cardiomyopathy.


Fellowships, and What they Entailed | Institutional Support in Europe | In the Shadow of Nazi Rule: Two generation units of social scientists | The Radio, Adorno, and the Panel | The History of an Appropriation | Reconnaissance Expeditions, Reconstruction Support,and the Rare Return | Red Threads | Appendix: Comparative Income


The goal of this study is to give an overview of the range of radioactive wastes remediated using such microorganisms, the mechanisms involved,and the possible applications for these processes. Particular emphasis is placed on the bioremediation of actinides and fission products. However,there is in many cases still a very significant gap between knowledge of radionuclide-microbe interactions obtained from laboratory studies using pure cultures of microorganisms under well defined conditions,and detailed understandings of the complex mechanisms of key radionuclides in microbial communities. Therefore, it is necessary to understand the mechanism that enables microbes to eliminate the radionuclides from contaminated sites. The present review discusses the status of these microbiological processes, and the potential for costeffective and scalable in situ remediation of radioactive waste.


Continuous-energy Monte Carlo Codes are not generally suited for adjoint coupled electron-photon transport. Line radiation (e.g., fluorescence) is especially difficult to implement in adjoint mode with continuous-energy codes. The only published work on adjoint electron Monte Carlo transport is Jordan. The adjoint capability of his NOVICE code is expedited by a multigroup approximation. More recently, a Boltzmann-Fokker-Planck (BFP) Monte Carlo technique has been developed for adjoint electron transport. As in NOVICE, particle transport with BFP Monte Carlo is neither entirely continuous energy nor entirely multigroup. The BFP method has been tested in the multigroup version of MCNP and is being integrated into the ITS code package. Multigroup data produced by the CEPXS cross-section-generating code is needed to operate the BFP codes in adjoint electron-photon mode. In this paper, we present adjoint electron-photon transport results obtained with a new version of CEPXS and a new multigroup version of ITS.


This invention provides a B cell epitope peptide and its identification method to neutralize helicobacterpylori urease B subunit, determines the antigen epitope corresponding with the monoclonal antibody 6E6 of helicobacterpylori urease B subunit, and confirms this B cell epitope is specific for the 6E6. The invention also provides a chimeric epitope vaccine and its preparation method containing B cell epitope and carrier protein BSA, and the B cell epitope has strong antigenicity.


1. Detailed karyotypic analysis of ten varieties of different geographical regions have been carried out.2. In the somatic counts all the varieties exhibited the similar chromosome number i. e. 2n=30.3. Chromosome type B1 and B2 have consistent appearance in all the varieties analysed.4. On the basis of chromosome types and genotypic variation in karyotypes it was concluded that these genotypes (varieties) share a common ancestor in origin and have gone under a series of structural alternations.5. Karyotypic analysis revealed that species under study follow a progressive evolutionary path way.6. According to the extent of karyotypic asymmetry 3 varieties out of ten can be grouped as primitive ones.


Background: Venetoclax combined with hypomethylating agents is a new standard of care for newly diagnosed patients with acute myeloid leukemia (AML) 75 years or older, or unfit for intensive chemotherapy. As precision therapy in AML expanded with the addition of venetoclax among others in the therapeutic armamentarium of AML, efficacy and safety reports in ethnic minorities are limited, with a background of well recognized inter-ethnic differences in drug response. Phase III data from VIALE-A, as well as VIALE-C, was limited for the Arab population as no site opened in the Arab world. We herein report our experience on the use of venetoclax with azacitidine in patients with newly diagnosed or relapsed/refractory AML in the Arab population.
 Methods: Retrospective-single center review on the use of Azacitidine with venetoclax in older patients (aged ≥60 years) with newly diagnosed AML, not eligible for intensive chemotherapy; secondary AML and relapsed or refractory AML. All patients self-identified of Arabic ethnicity. Patients who received previous BCL2-inhibitor therapy were excluded. Patients who received at least one dose of treatment (Azacitidine ≥3 days, >14 days of venetoclax) were included in the intention to treat analysis. Patients typically received azacitidine 75 mg/m2 intravenously for 7 days with oral venetoclax 400 mg daily for induction, with appropriate dose adjustment for concomitant use of azoles. This is followed by the same regimen in consolidation, with adjustment according to response and side effects at the treating physician's discretion. The primary endpoint was overall survival. The secondary endpoints include response rate, safety, and relapse-free survival.
 Results: Between July 2019, and July 2021, we identified 19 patients; 13 (68%) had newly diagnosed AML (ND-AML), and 6 (32%) had relapsed or refractory AML (R/R AML). The median age was 70 years (17-82). In the ND-AML, most patients had an adverse ELN 2017 AML (69%) with 23% having either intermediate or adverse AML (Negative for CBF, NPM1, FLT3-ITD and biCEBPA, but missing NGS data for adverse mutations Tp53/ASXL1 and RUNX1). Only one patient was classified as intermediate-risk AML. The overall response rate in the ND-AML was 77%, with 46% achieving complete remission (CR), and 23% CR with incomplete count recovery (CRi) [Table]. One patient achieved PR after the first cycle (blast 7% by morphology and 1.5% by flow cytometry) and did not have a subsequent bone marrow evaluation, however had a full count recovery. Among the responders in the ND-AML cohort, 4 deaths were noted. One death was related to COVID-19 associated pneumonia, one due to graft failure (at day 42 post Haplo-SCT), one due to septic shock, and one was related to relapse disease. The overall survival and relapse-free survival for ND-AML were 5.6 months for both [Figure].
 In the R/R AML, 66% had prior HMA exposure, and all patients did receive high-intensity chemotherapy. The median number of prior treatments was 3 (1-5). the response rate was 80% (4/5), with 60% achieving CR. All patients are still alive with a median follow-up of 7.6 months. One patient had progressive disease. One patient is early to evaluate and was not included in the response analysis [Table]. The 30-day mortality was zero in both ND-AML and R/R AML cohorts.

 Conclusions: In a majority of adverse risk ND-AML, and in heavily pretreated R/R AML, the response rate and overall survival is comparable to what has been previously reported. Our data support the use of this regimen in older patients with newly diagnosed AML, patients with relapsed or refractory disease, and those with adverse-risk features. This analysis is limited by the small number of patients, and by the lack of ELN 2017 favorable-risk AML. Future prospective and randomized studies are needed to clarify activity and safety in the Arab population, as well as in the high-risk AML subset.
 Figure 1 Figure 1.

 No relevant conflicts of interest to declare.


In this large population‐based prospective study among middle‐aged and older men and women, we found that height loss of >2 cm over a period of 4 yr is a significant predictor of future fractures. Serial measurement of height is, therefore, recommended among the elderly people.


With the home and overseas accounting scandal occurring,the quality of accounting information is oppugned by public.This paper has studied the status,causation and countermeasure of accounting information distortion,in order to solve this problem.


Whether Shun Da-wu is guilty is not an issue of penal law,but also an issue closely connected with financial law because the mission of penal law is just to recognize and protect the legal values of other positive legal disciplines with the severe penal liability.For this,in deciding this case,when the relative clause is not specific it is necessary to weigh it from the value of financial law.On the other hand,this case has also reflected some problems in our financial system,so the law should give corresponding response to it.