The personality of healthcare workers, including doctors, nurses, and any employee who directly provide supportive services to a patient, is vital in health service quality, contributing to the hospital's brand image. Malaysia has successfully built that brand image attracting many Indonesians to have health treatment in this country. This study aims to examine the effect of healthcare workers' personalities on health service quality at Malaysian hospitals. The study adopted the Big Five Traits and SERVQUAL models to measure healthcare workers' personalities and health service quality. One hundred respondents from the families in West Kalimantan, Indonesia, who had health treatment in Malaysia, were selected to respond to the statements based on a Likert scale. The regression model was employed in data analysis in which the healthcare worker's personality was an independent variable, and health service quality was a dependent variable. The regression test results show that agreeableness and emotional stability positively and significantly influenced health service quality at the 5% level, with each coefficient of 0.332 and 0.701. Due to less varied responses, conscientiousness, extraversion, and openness to experience did not significantly influence health service quality. That was supported by the high average index of health workers' personalities (4.14) and hospital services (4.27), indicating that the respondents agreed with healthcare workers' excellent personalities and health service quality in Malaysia. Each indicator in healthcare workers' personalities also significantly correlated with each indicator in health service quality.
Acknowledgment The authors thank the Faculty of Economics and Business, Tanjungpura University, for funding this study.


Ethics is the branch of philosophy that explores the nature of moral virtue and evaluates human actions. Philosophical ethics differs from legal, religious, cultural and personal approaches to ethics by seeking to conduct the study of morality through a rational, secular outlook that is grounded in notions of human happiness or well-being. A major advantage of a philosophical approach to ethics is that it avoids the authoritarian basis of law and religion as well as the subjectivity, arbitrariness and irrationality that may characterize cultural or totally personal moral views. (Although some thinkers differentiate between "ethics," "morals," "ethical" and "moral," this discussion will use them synonymously.)


Abstract - The recent trend in big data application has led the organizations to think about its application. Having in mind the importance of supply chain integration and learning the current study has attempted to explore the drivers of firm performance from the supply chain perspective. Data were collected from the employees working in the pharmaceuticals companies in Indonesia. Smart-PLS was used for data analysis. The results of the study showed that there is strong significant positive relationship between big data analytical capability and firm performance. Further the results also revealed a significant influence of supply chain integration and learning on the firm performance. The results also revealed supply chain agility as a significant positive mediator between the relationships of supply chain integration, big data analytical capability, learning and firm performance. All the hypothesis were accepted.


The present work aims at comparing the influence of accelerate depreciation and linear depreciation on the main dyna mical financial indexes in an investment plan. By way of strict demonstration and example analysis, it is concluded that the financial indexes in an investment plan can be improved by adopting accelerate depreciation.


Objective To observe the influence of angiotensinⅡreceptor antagonist(ARB)I and angiotensin-converting enzyme inhibitors(ACEI)on the efficacy of recombinant human erythropoietin(r-HuEPO)for improving anemia in the maintenance hemodialysis(MHD)patients with end-stage renal failure(ESRF).Methods MHD patients with ESRF were divided into 3groups according to using the different antihypertensive drugs:r-HuEPO + ACEI group(15cases),r-HuEPO + ARB group(15cases)and the control group(r-HuEPO +calcium antagonists, 15cases).The RBC counting and hemoglobin(Hb)were detected before treatment and in 0,4,8,16weeks after treatment.Results The values of RBC counting and Hb in 0,4,8,16weeks after treatment had no statistically significant differences in the intra-group comparison and the inter-group comparison of the r-HuEPO+ACEI group and the r-HuEPO+ARB group(P0.05).RBC counting and Hb after 16-week treatment in the control group were significantly higher than that before treatment(P0.05),compared with the r-HuEPO+ACEI group and the r-HuEPO +ARB group,the differences were statistically significant(P0.05).Conclusion ARB and ACEI may affect the efficacy of r-HuEPO for treating anemia.


This thesis presents an attempt to predict incoherent and coherent power spectra of uniformly exposed and processed photographic films from an emulsion model. The model was developed by Eugene Trabka and is based upon renewal theory. Comparisons are made between measured and predicted spectra and between different methods of obtaining power spectra. The conclusion is reached that the present model lacks sufficient parameters for accurate prediction of the power spectrum. Improvements to the model which might yield more accurate predictions are discussed.


The calculation method in computer aided design(CAD) of AMH system is introduced. The method combines software with surface magnetic charge method to calculate the magnetic field, with Runge-Kutta method to calculate electron trajectory. Simulation the landing and convergence and calculated AMH system adjust matrix.


"Manchester United: The Forgotten Fixtures" completes the post-war history of Manchester United Football Club, as it covers, in text and statistics, the games that rarely receive a mention in the history books. The book starts its journey immediately after the war years and continues up to the present day. It takes you the length and breadth of Britain and from Mallorca to Melbourne and from Israel to Iran, detailing often meaningless games of football at obscure, out of the way places, while also looking back at the non-competitive fixtures played at Old Trafford. The League Championship and domestic cup triumphs and failures, along with those in the European competitions, have been well documented in the past, but here, for the first time, is the book that completes the Manchester United history in words and statistics. On the pages of "Manchester United: The Forgotten Fixtures" they are all here, some four hundred odd games. It testimonials details of ground openings and friendlies etc, from 1946 to the present day, bringing Manchester United's statistical history up to date. The history of Manchester United Football Club is now complete. Illustrated with not just photographs, but programme covers and match tickets and other items of memorabilia, is a United history with a difference and for the first time in print it covers all those 'Forgotten Fixtures' and many others that were not known about in the first place.


This article develops two contrasting themes: 1) the prime importance of braille as the only medium of literacy available to blind persons; and 2) the widely perceived de-emphasis of braille instruction in the United States. Attention is also directed to the importance of braille in contributing to the quality of life attainable by blind persons. Resolutions of the American Council of the Blind are summarized, indicating the position that removal of deficiencies in the quantity and quality of braille instruction should be given high priority.


Field matching has been used to compute the transverse impedance of simple, cylindrically symmetric, perfectly conducting structures, the subregions of which are separated by radial cuts. The method is briefly described, and some early results are presented. (LEW)


Abstract The pollen morphology of the Burmanniaceae is very varied, including the following shape classes; ovoid, planoconvex, biconvex, spheroidal, ovoid reniform and tetrahedral tetrads. Two types of apertures, colpate and porate, are common as well as a probably atreme type. The sexine patterns are not very varied. All the species investigated have pollen grains which are pertectate. The morphological features and their taxonomical relevance are discussed.


This paper (published in two Parts) presents a detailed historical case study of the evolution of the Polaris, Poseidon and Trident weapons programmes, and of the development of the guidance and navigation technologies which are essential to their role in nuclear strategies. Over the last thirty years, these technologies have changed in the direction of greatly increased missile accuracy. Simultaneously, the strategic rationale of these weapons has shifted from that of ultimate retaliatory `counter-city' deterrent (the main perceived role of Polaris) to `counterforce' targeting of opposing silos and command posts (a major role of Trident II). Has technological change been an independent causal factor in this sequence, bringing into being a new strategy, or is technological change the consciously intended product of political will? Part I of this paper presents the historical material as far as the production of Poseidon: Part II will complete the history, and then discuss the various analytical frameworks commonly used to explain such developments.


The kinetics of the disproportionation reaction in which the Nd/sub 2/Fe/sub 14/B phase forms Fe, Nd-hydride, and Fe/sub 2/B under hydrogen has been investigated by thermopiezic analysis. These studies have shown that the disproportionation temperature is dependent on grain size, and is considerably lower for Nd-Fe-B alloys with submicron grain sizes when compared with the case material. Thus, melt-spun material disproportionates at a temperature about 300 degrees C below that of cast alloy (at a heating rate of 1 degrees C/min). In addition, the amount of Nd/sub 2/Fe/sub 14/B phase in the alloy can be related to the temperature range over which the reaction occurs and to the amount of Fe and Fe/sub 2/B that forms as a result of the disproportionation reaction. The latter can be monitored by measuring the magnetization of the disproportionated material. >


This paper aims at providing a framework for evaluating plotting from the standpoint of creative writing theory, and at analysing...


The composition,construction and characteristics of Chinese industrial control configuration software MCGS were introduced.Taking the project development for automatic powder molding machine control system as an example,the process of configuration with MCGS and main functions of the system were described in details.Engineering practices show that the system has easy operation and high reliability.It has wide application value.


To promote quality control of its language resources the European Language Resources Association (ELRA) installed a Validation Committee. This paper presents an overview of current activities of the Committee: validation of language resources, standardisation, bug reporting, patches of updates of language resources, and dissemination of results.


The chemical ionization mass spectra of various aliphatic nitro compounds have been studied. Almost all the nitro compounds form stable [M+H]+ ions in sharp contrast to the instability of their ions produced by other ionization techniques. The fragmentations of the [M+H]+ ions are discussed, the mechanisms and structures of fragment ions proposed being supported by quantum mechanical calculations. Correlations between chemical ionization mass spectra and structures of compounds studied are outlined. Reliable identification of mono- and polynitroalkanes and some related derivatives may be made by analysis of their chemical ionization mass spectra.


Most high-power electric fuses installed in DC distributions of automobiles employ silica sand (chemical formula SiO2) as arc quenching material to implement the limitation and subsequent interruption of high direct currents. This paper on arc quenching material describes the effects of the addition of silicone resin (chemical formula C2H6SiO) on SiO2 sand, based on the resistance of an arc discharge in SiO2 vapor mixed with silicone resin vapor. The measurement results obtained for the fuse operation of a model electric fuse show that the addition of silicone resin, e.g. an even coating of silicone resin on the surface of a Cu fuse element, attains a shorter arc quenching time. This phenomenon is subsequently explained based on the rise effect of an arc column resistance achieved by mixing with silicone vapor decomposition. The chemical compositions of high-temperature SiO2 vapor mixed with C2H6SiO vapor decomposition are evaluated to show the predominant chemical species at 30 000 K–5000 K for several C2H6SiO vapor concentrations, XCH . The results obtained for XCH of 10%–50% reveal that a H atom originating from C2H6SiO is present at high molar fractions above 0.1 over a wide temperature range of 12 000 K–5000 K. Further evaluations of the electrical resistivity ρR for the high-temperature vapor show that mixing with C2H6SiO vapor contributes to a rise in ρR at temperatures of 10 000 K–6000 K. A contribution analysis of the ρR reveals that the rise effect of the ρR is accomplished chiefly by the presence of a H atom that has dissociated from C2H6SiO.


Optical techniques are a promising technology to realize high frequency ultrasound arrays. High sensitivity and broad bandwidth have been demonstrated with thin film etalon sensors. We have previously demonstrated a 256-element etalon array with true parallel detection. A disadvantage of this approach is lower signal-to-noise ratio (SNR) due to the use of a linear CCD array. We are also exploring a serial approach where the optical probe beam is rapidly scanned to produce a 500-element etalon array. Higher SNR is achieved with photodiode detection and high optical probe power. The optoacoustic sensor is a thin film etalon consisting of a parylene layer with gold coatings on a glass substrate. A fiber coupled 785 nm diode laser is focused on the etalon, where the beam is rapidly scanned over a 5 mm line at a 50 Hz rate. The reflected beam is coupled into a multimode fiber and sent to an AC-coupled photodetector. The 25 MHz source transducer is driven with a 4 μs duration chirped waveform at a 50 kHz repetition rate. A 500 MHz 8-bit oscilloscope records the signals from all 500 elements before transfer to a workstation. Pulse compression, beamforming, and image display are performed with a graphics processing unit (GPU). The object is a wire target placed approximately 3 mm below the etalon surface. The chirped excitation provides an SNR increase of over 18 dB with respect to traditional impulse excitation. After pulse compression, the array data clearly shows the scattered wavefront from the wire target. The wire target is clearly visible, where the -6 dB width is 95 um. Our current system uses the GPU to perform off-line beamforming, where real-time execution is currently under development. An advantage of the serial approach over parallel detection is higher SNR, since the entire probe laser power is used to acquire the signal from an individual element. We are currently improving the system to provide B-mode images at video frame rates. We believe these results suggest the potential of optoacoustic arrays for video-rate ultrasound biomicroscopy.


The travel industry in both internal and external aspects, puts great emphasis on the notion of partnership for related personnel. The main element that must be preceded in partnerships is communication; communication is the first priority in acquiring competitiveness. This study focuses on the quality of communication which serves as the core role between travel corporations. Research was conducted to find out the effects of high-quality communication on trust and client satisfaction. Sampling was conducted by targeting general travel agencies and outbound travel agencies along with land operators located in Seoul and its metropolitan area; 156 and 155 employees were surveyed, respectively. The acquired data was applied using a structural model analysis for hypothesis testing. Research results displayed that first, the level of interaction among communication qualities had a positive effect. Second, trust had a positive effect on client satisfaction. Finally, the level of interaction among communication also had a direct positive effect on client satisfaction. Therefore, several suggestions including the basic behavior and position for improving relationships between travel agencies and land operators have been made.


The invention discloses a high elastic memory external member, which selects DTY 150D/144F, FDY 75D/36F, DTY200D/96 as the main raw material; a weaving method using 1A+4B+1A+5B+2A is applied on a fur machine and a gray cloth is woven; the gray cloth is memory textured with jty-50 in an alternated rapid high temperature and low speed constant temperature; repeated reinforcement is conducted on an elasticized machine; memory absorbing polymerization texturing is provided, making the fabric molecules high polymerized, the density increased and a memory blank fabric is formed preliminarily; after printing drying the blank fabric, the fabric is transferred downwards and the density is increased continuously on a WEC-50 memory ironing machine, making the density uniform, the contraction consistent, abilities like anti-compression and crease-resistance are provided, and a high elastic memory external member is formed which has a 99 percentage of memory index. According to the high elastic memory external member, jty-50 memory texturing in an alternated rapid high temperature and low speed constant temperature is adopted; repeated reinforcement on an elasticized machine is conducted; and memory absorbing polymerization texturing is provided, making the fabric molecules high polymerized and the density increased. The household weaving external member processed by using the memory blank fabric has advantages of good elasticity and health care, and is comfortable and makes up the inefficiency of traditional household weaving external members.


Exeter City Council has undertaken an employment land review (ELR) to provide an evidence base that will be used to inform the preparation of employment land policies and allocations in the Local Development Framework (LDF).


The main topic of this diploma theses is groin hernia issues. In the theoretical part of this work the clinical characteristics, ethiopathogenesis, complications and treatment methods are described. Attention is paid to the posibility of one-day surgery for groin hernia. The major part of the work is research based on a prospective study. The research was performed at the Surgical Department of the Pardubice Hospital and at the Surgical Department of the Nachod Hospital.


ABSTRACT The aim of this study was to evaluate the effect of inclusion of two acidifiers blend (with different protection levels) on the acidification potential in vitro, apparent total tract digestibility of diet nutrients, blood metabolites, and average daily gain of nursery piglets. Two commercial acidifiers blend additives (AC1 and AC2) were evaluated. The acidification potential of the two acidifiers blend added to the diet were tested by buffering capacity and initial pH in vitro. For the evaluation of apparent digestibility of diet nutrients, blood metabolites and average daily gain, two experiments were carried out. The AC2 acidifier had a greater effect on the initial reduction in pH and a lower linear buffering rate of the diet. The use of acidifiers did not improve the nutrient digestibility of the diets and had no effect on the blood metabolite concentrations of urea, total protein, albumin, globulin, and lactate. Although the inclusion of acidifiers in the diets did not affect the apparent total tract digestibility of the diet nutrients the inclusion of the AC2 acidifier at different levels showed a negative quadratic effect on the average daily gain, with the best inclusion level being 0.26%.


Principles and procedures of bookkeeping by the tax laws are not always equal to the principles and procedures of bookkeeping by the applicable Accounting Standards in Indonesia.Hal resulted in net profit before tax generated by the Financial Accounting Standards (GAAP) differ from net income before tax is calculated based on the tax laws, which better known as Taxable Income (PKP) from the taxpayers. This recognition should result in differences in the adjustments to such financial statements with fiscal correction, both positive and fiscal correction negative fiscal correction, in order to produce the amount of income recognized by taxation. The financial statements of companies that have been reported fiscal correction needs to be done so that the financial statements in accordance with the principle of taxation so that it can be determined amount of income tax payable (tax payable) which should be paid by the company.


Several studies have indicated that exposure to loud sounds activates a reflex which acts to damp sound transmission through the middle ear. Recent work by Fletcher and Riopelle demonstrated that subjects exposed to a tone loud enough to activate this reflex, and immediately afterward exposed to intense impulse noise, exhibit appreciably less TTS than when the activating tone is omitted. This study attempted to measure the amount of attenuation produced during stimulation by a 100 db, 2000 cps tone in the opposite ear by measuring monaural shift in threshold, ascertained by a tracking procedure. Test tones were 100, 500, and 1000 cps. (Previous investigators found that appreciable reductions in cochlear microphonics for these frequencies were produced by the acoustic reflex. The protection from impulse noise was observed at or below 1000 cps. Moreover, no masking from the stimulating tone would be expected.) Small consistent reductions in sensitivity (less than 5 db) occurred during contralateral stimulation; these changes rarely persisted as long as 90 sec. Changes observed were nsufficient to account for the reductions in TTS afforded by the stimulating tone in Fletcher and Riopelle's experiment. Explanations for this discrepancy and for the changes observed are discussed.


This paper critically examines the Seoul city government's attempts at the policy transfer of creative cities programmes, both as a policy borrower and as a policy lender, by using the emergent 'policy mobilities' approach. Seoul's way of actualising the idea of creative cities places more emphasis on local-serving administration, tourism and physical cultural infrastructure. The original creative city programmes have been transformed, ideologically and materially, by Seoul into a process of downsizing government organisations and workforce and limiting the use of public space. Seoul's attempt to be a policy lender is not a product of other foreign cities' policy transfer from Seoul, but the result of the city government's promotional practices. Its final outcome, thus bears relatively little relationship or similarity to the original policies, encountering unexpected administrative and operational problems, such as increasing debt and resistance from civil groups.


Simple Summary In Glioblastoma (GB), a malignant tumor of the central nervous system, diagnosis can currently only be obtained via tissue biopsy. In this study we were able to isolate GB derived extracellular vesicles (EVs) in the blood, after patients received 5-aminolevulinic acid (5-ALA) before surgery. This isolation is based on fluorescence caused by the accumulation of fluorescent protoporphyrin IX (PpIX) in these EVs. We show that these EVs contain various GB-related micro RNAs. While there are many ways in which our technique needs to be improved before being able to be implemented in the clinic, this study shows that detecting and analyzing circulating GB-derived EVs based on PpIX fluorescence is feasible. In the future, our technique could be developed to diagnose and monitor GB via blood samples instead of a brain biopsy. Abstract Background: In glioblastoma (GB), tissue is required for accurate diagnosis and subtyping. Tissue can be obtained through resection or (stereotactic) biopsy, but these invasive procedures provide risks for patients. Extracellular vesicles (EVs) are small, cell-derived vesicles that contain miRNAs, proteins, and lipids, and possible candidates for liquid biopsies. GB-derived EVs can be found in the blood of patients, but it is difficult to distinguish them from circulating non-tumor EVs. 5-aminolevulinic acid (5-ALA) is orally administered to GB patients to facilitate tumor visualization and maximal resection, as it is metabolized to fluorescent protoporphyrin IX (PpIX) that accumulates in glioma cells. In this study, we assessed whether PpIX accumulates in GB-derived EVs and whether these EVs could be isolated and characterized to enable a liquid biopsy in GB. Methods: EVs were isolated from the conditioned media of U87 cells treated with 5-ALA by differential ultracentrifugation. Blood samples were collected and processed from healthy controls and patients undergoing 5-ALA guided surgery for GB. High-resolution flow cytometry (hFC) enabled detection and sorting of PpIX-positive EVs, which were subsequently analyzed by digital droplet PCR (ddPCR). Results: PpIX-positive EVs could be detected in conditioned cell culture media as well as in patient samples after administration of 5-ALA. By using hFC, we could sort the PpIX-positive EVs for further analysis with ddPCR, which indicated the presence of EVs and GB-associated miRNAs. Conclusion: GB-derived EVs can be isolated from the plasma of GB patients by using 5-ALA induced fluorescence. Although many challenges remain, our findings show new possibilities for the development of blood-based liquid biopsies in GB patients.


Aimed at problem of that shadow elimination methods based on model or single feature are all having inherent drawbacks. A shadow removal algorithm based on multiple feature differences between pixels and the reference background pixels is proposed. The multi feature differences of the current pixel and the corresponding pixel of the background are inputted into GLVQ to classify the current pixel.The experiments proved the proposed method has better performance than that of some other methods.


We consider the attitude regulation of multibody flexible space structures via linear regulators. Prior experience indicated that such systems may have a severely limited domain of attraction. We show that for the class of systems of interest to us such limitations can be associated with the presence of a nearby subcritical Hopf bifurcation.


Toward solving some of the problems of low precision, poor stability, and complex calculation in the simultaneous localization and mapping (SLAM) of mobile robots, an improved cubature Kalman filter SLAM (ICKF-SLAM) algorithm based on the cubature Kalman filter SLAM (CKF-SLAM) algorithm is proposed. Firstly, the error covariance matrix of the state vector is obtained through the motion model and observation model of the mobile robot. Then, the information matrix is obtained by the inverse operation, and the information state vector is updated in the prediction and update phases. The proposed method reduces the computational complexity and improves the accuracy of the algorithm. Simulation results show that compared with CKF-SLAM, the root mean square error of ICKF-SLAM is reduced by 11.8%.


Starting from the definition of science it is shown how it is a central fundament of modern engineering. However, science is only one of its components, because long before science was incorporated to engineering this profession already existed as a human endeavour. It is indicated that engineering should not bow to science because the problems it faces and its methods to solve them are of a very different nature. Finally, it is stated that young engineers should not forget the importance of technical and empirical knowledge in the practice of their profession.


THE AUTHORS RECALL THE DIFFICULTIES ENCOUNTERED IN TESTING PAVEMENTS COMPRISING ROADBASES STABILIZED WITH HYDRAULIC BINDERS. IT IS HOWEVER, POSSIBLE TO OBTAIN SATISFACTORY RESULTS BY USING OBSERVATIONS ON PAVEMENT SURFACE CONDITIONS AND RESULTS OF STANDARD DEFLECTION TESTS, RADIUS OF CURVATURE, WAVE PROPAGATION AND CORE SAMPLING. THE IMPORTANCE OF MOST OF THE PARAMETERS MEASURED IS FAIRLY WELL KNOWN, BUT CALIBRATED, BUT CONTINUOUS MEASUREMENTS ARE NOT YET POSSIBLE. WITH THIS AIM IN VIEW, HIGH OUT-PUT DEVICES FOR NON-DESTRUCTIVE TESTING WERE DEVELOPED. SOME OF THEM ARE NEARLY AT THE OPERATING STAGE, E.G., LONG-CHASSIS DEFLECTOGRAPH FOR MEASURING THE RADIUS OF CURVATURE, PHOTOGRAPHIC DEVICE FOR THE CONTINUOUS RECORDING OF SURFACE CONDITIONS; OTHERS ARE STILL AT THE EXPERIMENTAL STAGE (HIGH-SPEED LIGHTWEIGHT VIBRATOR). A REVIEW IS PRESENTED OF METHODS OF ANALYSIS OF SEMI-RIGID PAVEMENTS SINCE 1965 TOGETHER WITH EXAMPLES OF PAVEMENT DETERIORATION. ATTENTION IS DRAWN TO THE NEED FOR PREPARING DATA SHEETS FOR PAVEMENTS AT THE TIME OF THEIR BEING PUT INTO SERVICE.


Black-feathered line of green-shelled laying hens( P1),while leghorn chickens( P2),and the 40-week-old hens of the segregating populations( F1,F2) were measured for the body sizes traits to study the inheritance of body size using major gene plus polygene mixed model. Model E-1,a two-pair additive-dominance-epistatic major gene plus additive-dominance polygene mixed genetic model fitted the best for shank girth,shank length,chest angle and chest width of hens at 40-week-old,with the heritabilities of major gene being 60. 89 %,61. 24 %,55. 62 % and59. 43 %,respectively. The best model for keel length and body slanting length was model E,a two-pair additivedominance-epistatic majorgene plus additive-dominance-epistatic polygene mixed genetic model,with the heritabilities of major gene being 16. 52 % and 30. 76 %,and the heritability of polygene for keel length being 7. 2 %. The polygene heritablity in six body size traits was not detected except for keel length, and the genetic efficiency of major genes is greater than polygenes.


Serious medication errors continue to exist in hospitals, even though there is technology that could potentially eliminate them such as bar code medication administration. Little is known about the degree to which the culture of patient safety is associated with behavioral intention to use bar code medication administration. Based on the Technology Acceptance Model, this study evaluated the relationships among patient safety culture and perceived usefulness and perceived ease of use, and behavioral intention to use bar code medication administration technology among nurses in hospitals. Cross-sectional surveys with a convenience sample of 163 nurses using bar code medication administration were conducted. Feedback and communication about errors had a positive impact in predicting perceived usefulness (&bgr; = .26, P < .01) and perceived ease of use (&bgr; = .22, P < .05). In a multiple regression model predicting for behavioral intention, age had a negative impact (&bgr; = −.17, P < .05); however, teamwork within hospital units (&bgr; = .20, P < .05) and perceived usefulness (&bgr; = .35, P < .01) both had a positive impact on behavioral intention. The overall bar code medication administration behavioral intention model explained 24% (P < .001) of the variance. Identified factors influencing bar code medication administration behavioral intention can help inform hospitals to develop tailored interventions for RNs to reduce medication administration errors and increase patient safety by using this technology.


Title of Thesis : Development and characterization of Bt Chickpea (Cicer arietinum L.) plants against its major pest, Helicoverpa armigera (Hubner) Full name of degree Holder : Surender Kumar Admn. No. : 2009BS41D Title of degree : Doctor of Philosophy Name of major advisor : Dr. Pushpa Kharb Degree awarding University/Institute : CCS Haryana Agricultural University Hisar-125 004, Haryana, India Year of award of degree : 2014 Major subject : Biotechnology and Molecular Biology Minor subject : Genetics Total number of pages in thesis : 53 + iv Number of word in abstracts : 302


Through subjective evaluation experiments, this paper constructed an emotional model suitable for Chinese popular music, and divides Chinese popular music into five categories: sentimental, soothing, joyous, exciting and heroic. By extracting short-time zero-crossing rate, short-time energy, spectrum centroid, MFCC, LPCC and other features, the SVM was used for building the classifier. The FA algorithm was used for optimizing the radial basis function parameters, the accuracy of 86.65% is obtained. Compared with manual tuning, the accuracy of SVM classification is increased by 2.37%. The experiment results can verify the emotional model feasibly. The FA-SVM modeling method is fast and accurate. It is suitable for emotional recognition of Chinese popular music.


A distributed system appears to be a promising approach to resolving critical networking limitations prevalent in a centralized topology. Extensions are required to current distributed software platforms to facilitate a better distributed system. This paper examines the architecture of two distributed software platforms, JADE and JXTA and proposes architectural extensions for a better distributed system. The extensions are discussed and implemented. It is shown that JADE is a superior platform in terms of efficient and latency, mainly due to the partially centralized approach of its agent management system. JXTA has advantages due to its de-centralized management system and unrestricted scalability.


Helicopters are used by the military and civilian communities for a variety of tasks and must be capable of operating in poor weather conditions and at night. Accompanying extended helicopter operations is a significant increase in pilot workload and a need for better handling qualities. An overview of the status and problems in the development and specification of helicopter handling-qualities criteria is presented. Topics for future research efforts by government and industry are highlighted.


There is a cold-start problem in the recommendation system field, which is how to profile new users and new items. The popular recommendation algorithm is an important solution to the cold-start problem. In this paper, we propose a new joint deep network model with auxiliary semantic learning for the popular recommendation algorithm (DMPRA). First, we define the items with a large quantity of review data and high ratings as the popular recommended items. Second, we introduce text analysis into the popular recommendation algorithm. We use the optimized CharCNN networks to learn the auxiliary semantic vectors from the users' reviews. Then, we use the Factorization Machine (FM) component and deep component to learn the corresponding vector representations of the items' attribute features. We use convolution to simulate the interaction of hidden latent vectors. This method can make the vectors interact more satisfactorily than traditional interactive representation methods. Finally, we provide the users with a reasonable popular recommendation list. The experimental results show that our algorithm can improve the AUC (area under the ROC curve) and Logloss (cross-entropy) of the popular items' prediction. In addition, we provide relevant explanations for some useful phenomena.


The article explicated situation of petrol strategic stockpile at home and abroad,analysing regional advantage,geography advantage,basis and rich petrol store located in the edge of Lanzhou,if it would become petrol stockpile base.On the basis of this,author conceives to build Lanzhou into petrol strategic stockpile base in the northwest.


This paper presents the data of tests with an internal combustion engine MWM adapted to Otto cycle, coupled to an electric generator with a capacity of 50 kVA, using natural gas . It is presented the characteristics and efficiency of the set for the purpose of comparison with its future operation using synthesis gas produced by a gasifier (biomass gas), to evaluate the feasibility of applying the system in remote locations, where biomass is available and system for transmitting electricity from other generation systems hampered by distance. The performance of the assembly was monitored at 0, 25, 50, 75 and 100% of its power capacity presented in increasing order of load voltages 220, 220, 221, 221 and 222 volts and currents 0, 25, 50, 75 and 100 amperes respectively for the load of 0, 9,5, 19, 27,5 and 38 kW the latter being the maximum output developed by the group


Gold surfaces modified with C3−C18-alkanethiols (CH3(CH2)X-1SH; HXSH; x = 3, 8, 12, 16, 18) and C16-alkanethiols, fluorinated at the outer 1, 2, 4, and 10 methylene positions (CF3(CF2)Y-1(CH2)XSH; FyHxSH; y = 1, x = 15; y = 2, x = 14; y = 4, x = 12; y = 10, x = 6) were characterized by He(I) UV-photoelectron spectroscopy (UPS). (Detailed X-ray photoelectron spectroscopic characterization of the partially fluorinated thin films is given in the Supporting Information). Long incubation times of the gold surface with the alkanethiol solutions lead to compact monolayer films for all of the alkanethiols, as indicated by the exponential decrease in emission intensity versus alkyl chain length for both the gold Fermi edge (UPS data), and by a parallel decrease in Au(4f) photoemission intensity using X-ray photoelectron spectroscopy. Changes in the effective work function of these surfaces due to the presence of significant interfacial dipoles are observed (i) as alkyl chain length is increased, and (ii) as the fr...


In vitro and in vivo mycofumigation effects of the volatileproducing fungus Nodulisporium sp. CF016 isolated from stem of Cinnamomum loureirii and the role of its volatile compounds were investigated against phytopathogenic fungi. The volatile compounds produced by Nodulisporium sp. CF016 inhibited and killed a wide range of plant and storage pathogens including to Pythium ultimum, Rhizoctonia solani, Fusarium oxysporum, Phytophthora capsici, Sclerotinia sclerotiorum, Colletotrichum coccodes, Magnaporthe oryzae, Alternaria panax, Botrytis cinerea and Penicillium expansum. Mycofumigation with wheat bran-rice hull cultures of Nodulisporium sp. CF016 showed in vivo antifungal activity against gray mold caused by B. cinerea and blue mold caused by P. expansum of apple. The most abundant volatile compound produced by Nodulisporium sp. CF016 was β-elemene followed by 1-methyl-1,4-cyclohexadiene, β-selinene and α-selinene. Nodulisporium sp. CF016 could be an attractive mycofumigant in controlling postharvest diseases of various fruits including apple.


The world over the age of consent is used as a child empowerment and protective tool. It has been argued that the age of consent supports teenagers as they negotiate the most profound aspect of childhood transition into adulthood. During this period, children and teenagers face abuse, bodily violence and exploitation. The study sought to analyse the perceptions and views of primary school teachers about age of consent within the educational setting. The study was guided by the interpretivist philosophy and was methodologically underpinned by the qualitative research design, particularly regarding data, which was collected utilising in-depth interviews and focus group discussions to solicit research participants' opinions, feelings, and thoughts that represent their world views. The study established that teachers had little knowledge about the age of consent due to misrepresentation in the legal frameworks and inconsistencies in the law on the matter.  In addition, customary, cultural, and religious practices remain "blind" in the way they approach children's rights issues. Thus, the article advocates for a child-centred framework when dealing with issues that affect the well-being of children as a way of demystifying the age of consent in the educational sector, which should also be informative not only to teachers but traditional leaders and legal practitioners so as to have a shared understanding of the concept.  It is recommended that the age of consent should be the same for both boys and girls just as the age of majority, which is at 18 years.


Invasive and noninvasive arterial imaging are important techniques used to study atherosclerosis and, specifically, to evaluate the atherogenecity of triglyceride‐rich lipoproteins (TRL). Serial coronary angiography trials show significant benefit from lowering low‐density lipoprotein cholesterol (LDL‐C) which serves to retard lesion progression. Even with aggressive LDL‐C reduction, however, up to half of patients demonstrate continued progression of atherosclerosis. Angiographic studies reveal that lowering LDL‐C has the most impact on severe lesions, those ≥50% diameter stenosis, whereas TRL (and their apolipoprotein markers) have been identified as a driving factor behind progression of mild‐to‐moderate lesions <50% diameter stenosis. Quantitative coronary angiography (QCA) has demonstrated that progression of mild‐to‐moderate lesions are among the most significant predictors of clinical coronary events, and that lowering TRL reduces progression of coronary artery disease to the same degree as the lowering of LDL‐C.


Tracking control of piezoelectric actuators is considered in the article. A Hammerstein model is used to depict the rate-dependent hysteresis characteristics of piezoelectric actuators, in which a Bouc–Wen model is to describe the static hysteresis characteristic, and a linear time-invariant system is to describe its rate-dependent characteristics. An inverse Bouc–Wen model connected in series with the piezoelectric actuator is used to compensate the static hysteresis nonlinearity of piezoelectric actuators. Furthermore, an extended state observer–based fractional order sliding-mode control is designed to deal with higher order unmodelled dynamics and inverse compensation errors. Moreover, the bounds of the estimation error of the extended state observer are estimated, and the convergence of the proposed control strategy is proved. Experimental results show that the proposed scheme can track both single and composite input signals within a certain frequency range. Compared with extended state observer–based conventional sliding-mode controller, the proposed scheme has faster response time and smaller tracking error.


The objective of this study is to investigate various modes of operating an activated sludge treatment to optimize the bioconversion of the pollutants. The study will present the operation conditions and the removal of contaminants due to various removal schemes. These later include limited sludge wasting, high temperatures, and co-adsorbers to the activated sludge biomass.


Pathological states occur when cerebrospinal fluid (CSF) and cerebral blood flow (CBF) dynamics become dysregulated in the brain. Phase‐contrast MRI (PC‐MRI) is a noninvasive imaging technique that enables quantitative measurements of CSF and CBF flow. While studies have validated PC‐MRI as an imaging technique for flow, few studies have evaluated its reliability for CSF and CBF flow parameters commonly associated with neurological disease. The purpose of this study was to evaluate test–retest reliability at the cerebral aqueduct (CA) and C2‐C3 area using PC‐MRI to assess the feasibility of investigating CSF and CBF flow dynamics.


Johor Tourism Awards Ranking System (JTARS )is a web-based system with is specially built for Johor Tourism Action Council (JTAC). This system is intended to assist the JTAC in the evaluation process of awards ranking. The current awards ranking system is operated manually which is time consuming. This makes the period to evaluate the candidates take longer time for judges. Base on this consideration, the JTARS online system is being built. Evaluation Prototype is chosen as development methodology. Microsoft Visual Studio 2008 Express Edition, ASP.NET and Microsoft SQL Server 2005 are chosen as interface designing tool, programming language and database system respectively. This system is expected to improve the process of the tourism awards evaluation in terms of speed and ease of works.


In order to improve the design efficiency of the product and the independent innovation ability of development,variant design technology of modular product based on hybrid reasoning was proposed on the basis of the analysis of main structure and working principle of the horizontal screw decanter. Variant design system of the horizontal screw decanter was developed based on that hybrid reasoning mechanism integrated with rule-based and case-based reasoning and applied to the entire product development cycle,and module division of the horizontal screw decanter hierarchically adopting modularity,and a set of complete and intelligent expert system integrated with the integration of expertise in the design field and professional knowledge. Finally,the standardization and intelligent of system are verified by the example.


The links between the fight against HIV/AIDS, and lesbian, gay, bisexual and transgender (LGBT) mobilizations around the world have been extensively demonstrated. However, there are few empirical studies on the effects of new strategies based on access to treatments for homosexuals in Africa, especially in countries where same-sex relationships are punishable by law. In discussing the relationship between HIV/AIDS policies and the formal recognition and inclusion of homosexuals, we ask if it is possible to speak of a therapeutic citizenship. From a sociological and legal perspective, what is important is how the recent global strategies and human rights discourses on HIV/AIDs are impacting the emergence of engaged social actors whose claims go well beyond access to treatments but challenge the Cameroonian legal and health systems. However, LGBT rights advocates' claim for full citizenship through participatory inclusion in public life may not turn out to be successful as it encloses their rights within a pathologized identity, the HIV epidemic. This paper also raises a crucial issue (citizenship) associated with the politics of homosexuality in Africa and offers an empirical dimension on how global health and human rights discourses affect the relationship between State and society in Cameroon.


We note with concern the methodology and conclusions of Waller et al. in their article on 'Barriers to cervical cancer screening attendance'. The authors began with a concern about falling cervical smear attendance rates and the premise that barriers exist to prevent women attending for smears. They asked women in interviews to explain their behaviour in not attending for a smear, using a set of questions comprising possible reasons for nonattendance. Yet nowhere do Waller and her colleagues consider that women may increasingly have simply decided not to have a smear. Non-attendance at smear appointments – especially when opting out is near impossible – may be due to a weighing up of the pros and cons of smear tests, and not only for the reasons of discomfort or embarrassment given by the authors. There is the low chance of avoidance of cancer as well as the risk of a falsepositive, leading to unnecessary treatment with its association with premature birth as described to the general public by the same organization that funded this research. Adults must be treated as competent, but they cannot make decisions about screening when they are not presented with it as a choice, with the potential for harm as well as gain. The only reasons cited for smear avoidance are effectively a list of excuses such that one fears being sent to the naughty step. The authors' conclusion that women who may be too busy both to vote and have a smear may be 'disillusioned' with public services negates the realistic statistical appraisal of the efficacy both of voting and of smear tests. Maybe some women are under no illusions? When it comes to screening autonomous adults, professionals have to remember that informed choice is an ethical right. We ignore this at our professional peril.


Any advances in our knowledge about the genesis of mammary cancer in mice may be attributed primarily to the availability of homozygous or inbred stocks. For research these strains are to the biologist as pure chemicals are to the chemist. If this analogy may be justified, one striking distinction should be mentioned, however. Whereas chemicals are generally stable over a long period of time, mice, like all living forms, are subject to "mutational" changes which may occur at any time regardless of the degree of inbreeding. Just as many investigators are interested in the biological effects of mutations induced by carcinogenic agents, investigators trained in genetics are constantly on the alert for mutations that occur spontaneously in control strains. If these are recognized they might compare with the synthesis of new chemicals, new "tools" for research; if they go unnoticed, the experimental results may be distorted because of the changes in the genetic constitution of the experimental animals and, therefore, may become the basis for new theories which cannot be confirmed. One purpose of this report is to review the resuits that have been secured by various investigators on the development of mammary cancer in mice, another is to bring together in a single article the observations from many analogous experiments which are now scattered throughout the literature. Some additional material will be included.


Porous mineralized scaffolds are required for various applications in bone engineering. In particular, tube‐like pores with controlled orientation inside the scaffold may support homogeneous cell seeding as well as sufficient nutrient supply and may facilitate blood vessel ingrowth. Scaffolds with parallely orientated tube‐like pores were generated by diffusion‐controlled ionotropic gelation of alginate. Incorporation of hydroxyapatite (HA) during the gelation process yielded stable scaffolds with an average pore diameter of approximately 90 µm. To evaluate the potential use of alginate–gelatine–HA scaffolds for bone tissue engineering, in vitro tests with human bone marrow stromal cells (hBMSCs) were carried out. We analysed biocompatibility and cell penetration into the capillary pores by microscopic methods. hBMSCs were also cultivated on alginate–gelatine–HA scaffolds for 3 weeks in the presence and absence of osteogenic supplements. We studied proliferation and osteogenic differentiation in terms of total lactate dehydrogenase (LDH) activity, DNA content and alkaline phosphatase (ALP) activity and found a 10–14‐fold increase of cell number after 2 weeks of cultivation, as well as an increase of specific ALP activity for osteogenic‐induced hBMSCs. Furthermore, the expression of bone‐related genes [ALP, bone sialoprotein II (BSPII)] was analysed. We found an increase of ALP as well as BSPII expression for osteogenic‐induced hBMSCs on alginate–gelatin–HA scaffolds. Copyright © 2008 John Wiley & Sons, Ltd.


Treatment of 3,4-di-O-acetyl-1,6-di-O-trityl-β-D-fructofuranosyl 2,3,6-tri-O acetyl-4-O-triflyl-α-D-galactopyranoside (3) with a halide source gave, via S N 2 displacement, the corresponding C-4 halogenated compounds which were subsequently transformed into the monohalogenated 4-deoxy-4-halogenosucrose derivatives, 10–12. Trihalogenated sucrose derivatives, 4-bromo-1′,6′-dichloro 17, 1′,6′-dibromo 18, and 1′,6′-diiodosucrose 19, were synthesized from 5. Exploiting the distinct reactivity at C-1′ and C-6′ trifluoromethanesulfonates enabled the introduction of different halogens at these positions. This pathway led to the preparation of the 4-bromo-1′,6′-dihalodeoxysucrose derivatives, 24–27. Preliminary taste properties of these mono- and tri-halogenated sucrose analogues were also investigated.


Objective To explore the effect of continuity of care model in patient with stroke and the influence on life quality. Methods 110 cases with stroke from January 2011 to April 2014 in our hospital were selected and randomly divided into the research group and the control group,54 cases in each group.The research group was given continuity nursing intervention mode,the control group was given routine care mode.The Barthel index,the degree of nursing satisfaction and the score of life quality in two groups was compared respectively. Results The Barthel index of the research group at 1,3,6 months after discharge was higher than that of the control group,with significant difference(P0.05).The degree of nursing satisfaction in the research group was 98.2%,which was higher than 85.5% in the control group,with significant difference(P0.05).The score of life quality of mental state,housework,family relations,work and economic aspect in the research group was higher than that in the control group,with significant difference(P 0.05). Conclusion The application effect of continuity of care model in patient with stroke is significant,which can effectively improve patient′s daily life ability and life quality.


We construct a C symplectic twist map g of the annulus that has an essential invariant curve Γ such that Γ is not differentiable and g restricted to Γ is minimal. We denote T = R/Z the circle and A = T × R the annulus. An important class of area preserving maps of the annulus are the so called twist maps or maps that deviate the vertical, since this class of maps describes the behavior of area preserving surface diffeomorphisms in the neighborhood of a generic elliptic periodic point. More precisely, a C diffeomorphism g of the annulus that is isotopic to identity is a positive twist map (resp. negative twist map) if, for any given lift g̃ : R → R of g, and for every θ ∈ R, the maps r 7→ π̃◦g̃(θ, r) is an increasing (resp. decreasing) diffeomorphisms. A twist map may be positive or negative. Here π̃ denotes the lift of the first projection map. An essential invariant curve by a diffeomorphism g of the annulus is a homotopically non-trivial simple loop that is invariant by g. When f is a C twist map, it is known from Birkhoff theroy that any invariant essential curve by g is the graph of a Lipschitz map over T. Furthermore, it was proven by M.-C. Arnaud in [A09] that the latter map must be C on a Gδ set of T of full measure. Numerical experiment show that the invariant curves of a smooth twist map are actually more regular than just what the Birkhoff theory predicts. Moreover, in the perturbative setting of quasi-integrable twist maps, KAM theory provides a large measure set of smooth invariant curves. The question of the regularity of the invariant curves of twist maps is thus a natural question that is also related to the study of how the KAM curves disappear as the perturbation of integrable curves becomes large. Another natural and related question is that of the regularity of the boundaries of Birkhoff instability zones. A Birkhoff instability zone of a twist map g is an open set of the annulus that is homeomorphic to the annulus, that does not contain any invariant essential curve, and that


The importance of having a good interface design may determine the success and failure of this endeavor. An unsuccessful designed user interface can be the cause of failure and it may appear as a user complaint. The results are disrupted operation, wasted time, effort and money, and failure to achieve the potential benefits of automated information handling. This study focused on improving proprietary software in NEC PBX where the researchers come up with an idea on how the proprietary software become a practical choice in configuring the NEC PBX where the authorized user can easily search specific features on the proprietary software called PCPRO. The project serve as a third party program embedded into the PCPRO where it simplifies the list of NEC PBX features. The researchers conducted an interview to a number of respondents to identify the problem. This led them to undergo a tough investigation on how to control and improve the proprietary software physically by the use of AutoItv3 software also known as "Automated Scripting Language", which made the creation of the application successful. The application used Microsoft Visual Studio .NET.


Ships in shallow water and at high speed suffer from extremely high wave resistance. A possible solution is to use a multi-hull, with destructive interaction between the bow and stern waves of the different hulls. This has been done in several ship designs, including the recent littoral combat ship USS Independence (LCS-2) In deeper water and at lower speed, the need for reducing the wave resistance is less present, and a multi-hull undergoes larger viscous friction than a mono-hull, since it has more wet surface. This study pleads for a trimaran of which the three hulls can be merged into a single one, enabling the ship to be configured optimally for different water depths and ship speeds. In trimaran configuration the main hull leads the other two, which are positioned symmetrically behind it. Two positioning parameters remain: (1) the distance, parallel to the ship speed between the leading and the rear hulls, and (2) the lateral distance between the two rear hulls. The Froude depth number is a crucial parameter in research in shallow water ship resistance. For a range of Froude numbers (or combinations of ship speed and water depth), the optimal configuration has been calculated, using OpenFOAM and a generic optimization loop: either the mono-hull or the trimaran with optimal distance parameters. This finally is a valuable argument to support the concept of a reconfigurable ship hull.


The primary bargaining power of organized labor is its ability to withdraw labor from the Ž rm in the form of a strike. From the workers' perspective, a strike is intended to impose substantial costs upon the Ž rm. Over time, as these costs accumulate, the Ž rm develops an appreciation of the solidarity of labor and may eventually surrender to the demands of the workers. Orley C. Ashenfelter and George E. Johnson (1969) note that the strike also serves the function of informing the workers to the reality of the Ž rm's position. Although the union leadership may recognize early in negotiations that the Ž rm cannot or will not meet the workers' demands, the rank and Ž le of the union often do not understand the impracticality in their position until the workers have struck and the Ž rm fails to surrender. Whether strikes ultimately serve as a lesson to workers or Ž rms is partially impacted by the extent to which such events impart costs upon both the Ž rm and the industry. For example, Brian E. Becker and Craig A. Olson (1986) examined the relationship between worker strikes and changes in shareholder equity. These authors found that on average, a strike of at least 1,000 workers would reduce shareholder equity by 4.1 percent. Richard A. De Fusco and Scott M. Fuess, Jr. (1991) examined airline carriers and found that strikes tended to redistribute wealth from shareholders of those airlines which experienced a strike to shareholders of airlines that had management-labor peace. Furthermore, Richard McHugh (1991) investigated the impact of a labor strike on both the Ž rm and organizations linked as purchasers or suppliers. Surprisingly, the impact of the strike was greater for the linked Ž rm than it was for the Ž rm directly experiencing the worker strike. Each of the aforementioned studies found that strikes impose costs on the Ž rm. These costs generally centered on the loss of output the Ž rm experienced during the duration of the management-labor con ict. Previous studies have largely neglected the possible extended costs associated with the reactions of the remaining party impacted by the worker strike, the consumer. Although in many industries Ž rms can increase inventories prior to a worker strike, this is not true in all industries. Within the airline industry, for example, labor strikes temporarily force consumers to either consume the production of other suppliers or live without the particular good or service. This outcome leads to the question we investigate: Do work stoppages permanently impact consumer demand when the struck Ž rm is unable to meet demand during the labor strike? A natural setting to explore this issue is the professional sports industry. In such an industry, worker strikes can completely remove the output from the consumer's consumption basket. Unlike strikes in other industries, though, consumers of the output from the professional team sports industry frequently threaten to withdraw all future demand if worker strikes are not avoided or ended quickly. This threat has led industry insiders to claim that labor strikes might destroy the professional sports league experiencing management-labor difŽ culty.


Endoscopic sphincterotomy (ES) has been utilized for treatment of biliary tract diseases for almost three decades. Consequently, the long-term complications associated with the procedure such as recurrent common bile duct (CBD) stones, cholangitis, and stenosis at the site of sphincterotomy are well known; they are reported to occur in 5–24% of cases [1–3]. However, development of acute recurrent pancreatitis as a long-term complication of ES was not mentioned in the literature until 1993. At that time Asbun et al. reported attacks of recurrent pancreatitis in three patients, caused by stenosis of the pancreatic orifice, which emerged after ES [4].


The influence of three clonal rootstocks ('Pixy', 'Fereley' and 'St. Julien A') along with seedlings of Myrobalan(control) on growth, yield and fruit quality of plum cultivars 'Čačanska Najbolja' and 'Čačanska Lepotica' was studied in the Belgrade region (Serbia) for the six year-period (2013–2018). In comparison to control, clonal rootstocks have shown a significant effect on the decrease of trunk cross-sectional area. The lowest vigor was found in trees on the 'Pixy' rootstock, then on 'Fereley' and 'St. Julien A'. Yield per hectare on trees grafted on clonal rootstocks was higher for 62–82% in 'Čačanska Najbolja', and for 26–27% in 'Čačanska Lepotica' compared to Myrobalan. In cultivar 'Čačanska Najbolja' significantly higher fruit weight compared to control was obtained in the trees on the 'Fereley' and 'St. Julien A' rootstocks. The effects of rootstocks on the contents of soluble solids and total acids in the fruit were not significant. All three studied clonal rootstocks showed better results than standard Myrobalan, and can be recommended for establishing intensive plum plantations with higher planting density.


A series of 21 O- and N-Mannich bases of 3,4-dihydropyrimidinones (2a-j and 3a-k) were synthesized by using microwave irradiation technique by multi-component reaction in two steps. All the compounds were evaluated for their free radical scavenging activity by four methods. Structure activity relationship studies revealed that the compounds 2h, 2g, 3h and 3g exhibited profound antioxidant properties compared to standard ascorbic acid. Among O- and N-Mannich bases, N-Mannich bases were found to be more potent in scavenging free radicals. The correlation between structure and activities of these compounds with concern to drug likeliness profile and other physico-chemical parameters are portrayed and verified experimentally.


Just as there is a mechanism which pulls the eyes away from the center of gaze, so must there be a mechanism which brings the eyes back to the central position. The validity of a hypothetical mechanism of eye centering can be discerned in the following clinicopathologic and experimental studies of man and monkey. In normal man and monkey all eye movements are bilateral, whereas motor acts in the rest of the body may be unilateral or bilateral. Discrete unilateral as well as bilateral movements can occur in the face, neck, trunk, and extremities, but it is quite unusual for man to move one eye at will. Both eyes move synchronously for any given performance. Not only do they move at will rapidly and with great precision in any desired direction, but they coordinate in such a way that the requirements of binocular vision are met without the occurrence of


The article presents a methodology for the application of IT-technologies in teaching discipline "Management of innovation projects," which helps students to be more competitive and gather the useful skills for their future specialization in high-tech areas. IT-technologies are widely used nowadays in educational and training spheres especially in knowledge-intensive disciplines such as systems analysis, the theory of games, operations research, theory of risks, innovation management etc. For studying such courses it is necessary to combine both mathematical models and information technology approaches for the clear understanding of the investigated object. That is why this article comprises both the framework of research and the IT-tools for investigation in the educational process. Taking into consideration the importance of the IT-system implementation especially for the university we assume to suggest the methods of research in the area of innovation projects with the help of IT-support.


In this paper, we develop a framework for considering the problem of optimal resource capacity management in general stochastic loss network systems. The stochastic optimization problem consists of determining the capacities of different types of resources that minimize the total weighted loss probabilities over the entire time horizon. Since computing the exact (multi-dimensional) Erlang formula is #P-complete in the size of the network, we first consider the canonical Erlang fixed-point approximation for the blocking probability. We further propose a QED fixed-point approximation for blocking probability which is shown to be asymptotically exact and always outperform Erlang fixed-point approximation. We then improve the stochastic optimization problem by the QED fixed-point approximation. We also design an iterative algorithm to solve the optimization problem and show that it has a unique solution. We numerically demonstrate that it yields an improved solution compared to the optimization problem based on the Erlang fixed-point approximation. Numerical experiments have be obtained to confirm and support our theoretical results.


Design-time analysis and verification of distributed real-time embedded systems necessitates the modeling of the time-varying performance of the network and comparing that to application requirements. Earlier work has shown how to build a system network model that abstracted away the network's physical medium and protocols which govern its access and multiplexing. In this work we show how to apply a network medium channel access protocol, such as Time-Division Multiple Access (TDMA), to our network analysis methods and use the results to show that the abstracted model without the explicit model of the protocol is valid.


There is considered the realization of gender stereotypes in womens prose. There is substantiated that womenwriters are creators and interpreters of gender-role stereotypes. These gender-role stereotypes influence readers subconsciousness.


In this paper, we propose a linearly convergent inexact PP14 for minimization, where the inner loop stops when the reIative reduction on the residue (defined as the objective value minus the optimal d u e ) of the inner loop subproblem meets some p r e w j i g n e d constant. This inner loop stopping criterion can be achieved in a fized number of iterations if the inner loop algorithm has a linear rate on the regularized subproblems. Therefore the algorithm is able to avoid the computationally expensive process of solving the inner loop subproblems exactly or asymptotically accurately a process required by most of the other linearly convergent PPAs. As applications of this inexact PP-4, we develop linearly convergent iteratior, schemes for minimizing functions with singular Hessian matrices, and for solving hemiquadratic extended linear-quadratic programming problems. We also prove that Correa-LemarCchal's "implementable form" of PP-4 [2, Algorithm 3.31 converges linearly under mild conditions.


This book, edited by Dr. Suman Chakraborty, who is currently professor in Mechanical Engineering Department and the Advanced Technology Development Centre at the Indian Institute of Technology, Kharagpur, contains ten chapters. Each chapter is written by leading experts in the corresponding field of research interests. The chapters describe a wide range of issues such as capillary transport, fluid resistance, electrokinetics, substrate modification, rotational microfluidic, and the applications of these phenomena in various situations from non-biological to biological ones. The whole monograph is a comprehensive compendium of the developments, achieved during roughly the last decade, in the most of important topics of microscale transport processes. It represents an optimal balance between detailed fundamental theoretical approaches and concrete applications. The content of the book is best characterized by the titles of the ten chapters:


This essay explores the fluctuations in and short-lived nature of urban school reform through a study of the Education Action Zone (EAZ) programme of Britain's New Labour government. Using the notion of civic capacity as a theoretical framework, the essay looks at this reform from the perspectives of its government proponents, critics outside of government and those who work within one such zone in an economically distressed borough of London given the pseudonym of North Upton. The essay concludes by looking at what our case study of North Upton tells us about the causes of this problem and how it may be remedied. … governing board was skeptical here. They didn't believe that the money would actually be forthcoming. They felt that the sorts of activities that we might involve ourselves in would detract from our core task of education and instead of being clear about getting all children to certain educational levels, we might be involved in interesting and exciting or different or weird kinds of subjects which would detract. They weren't keen on that. They felt that it would take up a lot of my time and energy and so I wouldn't be able to devote myself to what I should be doing. They were unhappy that somehow their powers might be ceded to the forum.


Skeptikos means Inquirer, someone who is unsatisfied and still looking for truth. Pyrrhon of Elis, the founder of Greek Skepticism about 300 BC, is said to have sought mental peace by not making up his mind about any particular view of anything-a paradigm of indecision. The most famous skeptic is "Thomas, called Didymus," the doubting disciple. He said, "Except I shall see . . . , I will not believe." "Then saith he [Jesus] to Thomas, 'Reach hither thy finger, and behold my hands . . . and be not faithless, but believing. . . . Because thou hast seen me, thou hast believed: Blessed are they that have not seen, and yet have believed" (John, Chapter 20). In the first place, Thomas missed the committee meeting with the other disciples; probably he was off doing a visiting professor stint. So later Jesus repeated the demonstration just to convince the absentee. But as I read the Book, He was too human to resist expressing then his annoyance at Thomas' stubbornness by also proclaiming a special blessing for those who believe without requiring the evidence. In 1782, before we knew about geologic movements of great land masses, President Clinton's namesake Tom describedl the then inexplicable phenomen of seashells on the mountains in Virginia. His discussion concluded, "Ignorance is preferable to error; and he is less remote from the truth who believes nothing, than he who believes what is wrong." I shall presume, gentle reader, that you belong to the exclusive and open-minded but less specially blessed class of Doubting Thomas and Tom Jefferson. Neuroskepticism is only curiosity expressed by a neurologist, not necessarily malicious, and no different in practice at the bedside from that at the bench. I reject the concept that clinical diagnosis and management are only automatisms of examination, test requisition, and prescription. Clinical neuroskepticism implies no lack of sympathy or belief in each patient. Rather, it is an alert, openminded attitude of attention to the fact that the gait in the examining room is different from that in the waiting room. How and why is the spouse's description of symptoms different? What data supported earlier diagnoses?


In view of the pollution problems caused by the rural domestic sewage,and considering finding the optimum solution of domestic sewage treatment,decentralized treatment technology with energy-saving,good efficiency and low investment have been attracted more and more attention in our country.The paper introduces the source of rural domestic sewage and the statues of treatment in China,and then analyses principle,characteristics and applications of the main decentralized treatment technologies at home and abroad.So the selection principle of the rural domestic sewage treatment technology is discussed in order to provide references for the choice of the suitable rural domestic wastewater treatment technology in our country.


IJSER © 2013 http://www.ijser.org Abstract— Cycle/loop detection is a well known problem in graph theory. Surveyed literature shows that this problem has been studied in diverse domains like operating systems, circuit analysis, network analysis, curriculum adjustment and automata theory. Efforts have also been made to study it in the context of handwriting and digital signature recognition. However no attempt has been made to completely illustrate the cycle detection process in signature images/alphabetic characters despite the fact that cyclic structures form an inherent part of many characters and human signatures. This paper shows techniques for finding out cycles/loops in signature images by analyzing their neighboring pixels & then applying the Depth First Search algorithm and a variant of it. Results of the technique are promising.


Motivation: Detection of DNA at low abundance with respect to the entire sample is an important problem in areas such as epidemiology and field research, as these samples are highly contaminated with non‐target DNA. To solve this problem, many methods have been developed to date, but all require additional time‐consuming and costly procedures. Meanwhile, the MinION sequencer developed by Oxford Nanopore Technology (ONT) is considered a powerful tool for tackling this problem, as it allows selective sequencing of target DNA. The main technology employed involves rejection of an undesirable read from a specific pore by inverting the voltage of that pore, which is referred to as 'Read Until'. Despite its usefulness, several issues remain to be solved in real situations. First, limited computational resources are available in field research and epidemiological applications. In addition, a high‐speed online classification algorithm is required to make a prompt decision. Lastly, the lack of a theoretical approach for modeling of selective sequencing makes it difficult to analyze and justify a given algorithm. Results: In this paper, we introduced a statistical model of selective sequencing, proposed an efficient constant‐time classifier for any background DNA profile, and validated its optimal precision. To confirm the feasibility of the proposed method in practice, for a pre‐recorded mock sample, we demonstrate that the method can selectively sequence a 100 kb region, consisting of 0.1% of the entire read pool, and achieve approximately 500‐fold amplification. Furthermore, the algorithm is shown to process 26 queries per second with a $500 palm‐sized next unit of computing box using an Intel® CoreTMi7 CPU without extended computer resources such as a GPU or high‐performance computing. Next, we prepared a mixed DNA pool composed of Saccharomyces cerevisiae and lambda phage, in which any 200 kb region of S.cerevisiae consists of 0.1% of the whole sample. From this sample, a 30‐230 kb region of S.cerevisiae chromosome 1 was amplified approximately 30‐fold. In addition, this method allowed on‐the‐fly changing of the amplified region according to the uncovered characteristics of a given DNA sample. Availability and implementation: The source code is available at: https://bitbucket.org/ban‐m/dyss.


The potential energy (PE) surfaces of the electronic ground and the lowest excited states relevant to photophysics of interconversion of the 2-hydroxypyridine/2(1H)-pyridone system are characterized by ab initio calculations. The energy calculations at the optimized geometries are performed with the aid of the second-order perturbation theory, employing the complete-active-space self-consistent-field (CASSCF) wave function as the reference (CASPT2). Results confirm the earlier hypothesis based on the CASSCF calculations (Chem. Phys. Lett. 1993, 211, 293) that the photoinduced dissociation−association (PIDA) mechanism is probably responsible for excited-state tautomerization observed in this system. Absorption of the second photon in the excited electronic state is suggested to provide the "driving" force for the PIDA mechanism.


Abstract : Over the past century, U.S. relations with Russia have evolved from ally to enemy to strategic partner to competitor. The political landscape and national interests of the Russian Federation have changed since the breakup of the Soviet Union. As a result, relations between Russia and the United States today are strained, largely because of Russias actions in Ukraine. Understanding Russias intentions has been challenging and difficult in the past for the United States. This monograph argues that Russias foreign policy is driven by four overarching factors: Russian President Vladimir Putins approach to the world around him; the Kremlins desire for centralized control of the population; Russias desire to protect its homeland through an outside buffer zone; and an enduring distrust of the West. Given these drivers of Russian foreign policy, deterring Russia without provoking conflict or creating a spiraling security dilemma is a difficult task. Russias actions in Crimea and eastern Ukraine have put the Baltic States and Eastern Europe on edge. The primary challenge for the United States and the North Atlantic Treaty Organization (NATO) is to deter both a conventional threat and an ambiguous (footnote 1) threat as Russia works toward achieving its objectives. The most dangerous scenario facing the West is a Russian advance into Alliance territory with conventional forces, but many assume this is not very likely. Alternatively, an indirect Russian approach using ambiguous warfare to fracture the Alliance and increase Russias influence in Europe is far more likely. In attempting to devise solutions that would address both a conventional and an ambiguous threat, this monograph theorizes that based on current force structure, NATO lacks the capability to defeat a surprise Russian conventional attack into the Baltic States or Eastern Europe, regardless of the likelihood of such a scenario.


Ecological construction had been a hot topic for environmental degradation since the late 20th century. The goal of ecological construction is to assure from planning to implementing minimal environmental impact and to achieve the environmental, economical, and social benefits together. Ecological construction is also a kind of social activity, which means human power on environment. The system is helpful for ecological construction going well and social development sustainable. Based on the study on the concept and course of ecological construction, a driving system with several interacting drivers has been proposed in this article.


Kalman and PID controller are used to design UAV (Unmanned Air Vehicles) formation flight control system for speed and pitch angle. UAV adjusted the PID parameters to realize control stability of UAV flight. The simulation results will show that Kalman and PID controller have better dynamic performance than the traditional controller in respect of simpler design, higher precision, easier implement, etc. At the same time, the control effect will be significantly improved. In addition, Kalman & PID control is superior in short transition, good stability, anti-disturbance, good control and etc, it also fulfills the requirement of real-time and accurate control.


Abstract Developments in communication technologies have brought about the proliferation of self-mediated textualities and empowered networks of non-professional translators to engage in participatory subtitling practices. These subtitling agencies are often part of a movement of cultural resistance against global capitalist structures and institutions, whether for aesthetic or political reasons. This article gauges the extent to which participatory subtitling challenges assumptions underpinning traditional scholarship on intercultural communication, as instantiated in the pragmatics of audio-visual translation. It is argued that affectivity emerges as a powerful non-representational force behind amateur mediation. Rather than simply aiming to deliver 'accurate' representations of the source text meaning, amateur subtitles seek to performatively intervene in the articulation and reception of the audio-visual semiotic ensemble. Drawing on selected examples of aesthetic and political subtitling activism, this article examines the relevance of non-representational theory, originally developed within the field of human geography, to the study of the expressive or transformational role of amateur subtitling. It is suggested that the epistemological and political dimensions of this non-representational phenomenon are symptomatic of a wider trend towards a radical model of democracy.


A rapid, sensitive, accurate and precise high-performance liquid chromatography–tandem mass spectrometric (HPLC– MS/MS) method equipped with Electro Spray Ionization (ESI) source, operating in the Positive ion and Multiple Reaction Monitoring (MRM) mode was developed and validated for the estimation of Phenytoin in human plasma using Phenytoin D10 as an internal standard. Liquid-liquid extraction (LLE) technique was used to extract analyte and ISTDs from 0.2mL human plasma. The analytical separation was carried out in a reverse phase liquid chromatography by using C18 (150 x 4.6mm, 5µm) column, and 2mM Ammonium Acetate in water (pH 6.3): Methanol (30:70% v/v) mobile phase at 1mL/min in isocratic mode. Analytes were monitored in multiple reactions monitoring (MRM) mode using the respective [M+H]⁺ ions, m/z 253.10→ 182.30 for Phenytoin and m/z 263.30 → 192.20 for the internal standard, respectively. The Phenytoin and Phenytoin D10 retained at about 2.50 and 2.46 minutes respectively with total run time of 4 minute. The response of the LC-ESI-MS/MS method for both analyte and ISTD was linear over the dynamic range of 60-12000ng/mL with correlation coefficient r2 ≥ 0.9963. The Accuracy was well within the accepted limit of ± 20% at lower limit of quantification (LLOQ) and ± 15% at all the other concentrations in the linear range. Recovery of drug and ISTD was 87.52% and 86.42%, respectively. This method was fully validated for all the validation parameters and Stability studies. After optimization, the Bioanalytical method was validated according to USFDA, EMA and ANVISA guidelines for Bioanalysis.


Based on the local patch concept, we proposed locally recon- structive patch alignment (LRPA) for dimensionality reduction. For each patch, LRPA aims to find the low-dimensional subspace in which the reconstruction error of the within-class nearest neighbors is minimized and the reconstruction error of the between-class nearest neighbors is maximized. LRPA preserves the local structure hidden in the high- dimensional space. More importantly, LRPA has natural connections with linear regression classification (LRC). While LRC uses reconstruction errors as the classification rule, a sample can be classified correctly when the within-class reconstruction error is minimal. The goal of LRPA makes it cooperate well with LRC. The experimental results on the extended Yale B (YALE-B), AR, PolyU finger knuckle print, and the palm print databases demonstrate LRPA plus LRC is an effective and robust pattern-recognition system. © 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). (DOI: 10.1117/1 .OE.51.7.077208)


This study was undertaken to find out the relation between the contents of aluminum and iron in galvanizing bath for the formation of alloy.The following equation was obtained on the assumption that iron forms FeAl3-Zn alloy as floating fine dross in the bath.CEAl=CTAl-1.45CFewhere CEAl: Aluminum content effective for preventing the formation of alloyCTAl: Total aluminum content retained in the bathCFe: Iron content floating as fine drossAccording to the above equation, the minimum aluminum content effective for preventing the formation of alloy layer was 0.12% under the following experimental conditions: bath temperature of 450°C and dipping time of 50sec.


The WISE workshop was convened to review results from the Women's Ischemic Syndrome Evaluation (WISE) study and other studies of ischemic heart disease to examine the nature and scope of gender differences in both chronic and acute cardiac ischemia, in terms of clinical manifestations, detection, and treatment. This section addresses research needs in the diagnosis and treatment of acute coronary syndromes in women and in the effective implementation of these findings into the community.

There is a substantial body of scientific literature about the presentation of acute cardiac ischemia (ACI) in women, including acute myocardial infarction (AMI) and unstable angina pectoris, which can lead to AMI. However, the diagnosis and treatment of ACI in women in the emergency department (ED) is not optimal, resulting in missed diagnoses and treatments and leading to excess mortality.1 Women present at older ages, in different social support environments, with more comorbidity, and with some differences in symptoms compared with men, and women are more likely to present with unstable angina pectoris than with AMI.2–8 Also, gender-specific clinical practices are not well understood or implemented.9–18 Particularly needed for improving health outcomes in women with ACI is a better understanding of how care for women with (and without) ACI can be effectively delivered in the wide range of care settings in this country. Thus, there is a clear need to supplement prior, excellent, disease-targeted "efficacy research" with "effectiveness research" that targets the development and testing of approaches that are broadly applicable to usual clinical practice settings.19,20 This next phase of research must avoid the incomplete inclusion of all patients with …


This paper discusses the relationship among the president, the prime minister and the parliament of Russia under the Constitution of the Russian Federation (1993). Although the legal system of Russia recognises independent functions of each state branch based on the principle of separation of power, it fails to provide genuine instruments that can limit the president from accumulating power in the executive branch. It is designed in a way that not only persuades imbalance in power distribution, but also gives a constrict space to the prime minister and the parliament to appear independent in a series of interactions and, therefore, resulting in an undemocratic political process and derailed economic development.


Concept-based information retrieval is known to be a powerful and reliable process. However, the need of a semantically annotated corpus and its respective data structure ± e.g. a domain ontology ± can be problematic. The conception and enlargement of a semantic index is a tedious task, which needs to be addressed. We previously suggested an annotation propagation approach in a vector space representation of the corpus to help users enriching a corpus. In this paper, we propose an extension of this process for semantic indexations. Starting from a map showing the documents of the corpus, a user will just have to place a new resource on this map to obtain a first annotation of this resource. This annotation is obtained by optimizing an objective function, which assesses the semantic similarity between the annotation suggested for this new resource and those of documents found in its vicinity. Here, we illustrate this strategy on tumor-related scientific papers. MOTS-CLES : Indexation par propagation, indexation conceptuelle, similarite semantique, recherche d'information conceptuelle, interaction homme-machine.


An integrity management system for Xining gas pipeline was introduced,which has been proved successful.The integrity management system is a method commended by ASME.The integrity management system includes data collection,risk analysis and integrity assessment,etc.It provides a method to improve pipeline safe state and reduce accidents probability to avoid a great loss of people's lives and properties.


Red-spinach ingredient Oxystorm claims to provide "more than five times the amount of nitrate as beetroot powder and more than 50 times of beet juice."


The amount of data communications is rapidly increasing due to the fast-growing demands of internet services. To maintain satisfactory quality of service, the service providers are establishing the quality indexes. These indexes are known to be provider-centered and network-centered. In this study, we focus our investigation on the quality index from the users' point of view. In specific, the QoS (Quality of Service) requirements from the users' viewpoint for the high-speed internet service, such as ADSL or cable modem, are captured by referring to the framework presented by the FITCE study commission. To capture the users' requirements, the survey has been conduct ed for the subjects of
ages of twenties and thirties living in Seoul. As a result of the survey, the cells which users put more importance on are identified. By converting the cells of high ranks into the corresponding quality indexes, the user-centered quality indexes
are derived.


In the context of using translation and teaching of foreign languages, some studies have shown positive results by combining translation activities with the practice of didactic sequences, from authentic textual genres. Thus, within the framework of the interdisciplinarity in Translation Studies, this research proposes the translation of theater plays for Portuguese, from a didactic sequence that approach concrete cases of linguistic variation in the Spanish language. Thereunto, this research is based in the Functionalist Theory of Translation, as well in the approximation between translation and linguistic variation, along with the instructional sequencing of textual genres. To illustrate this proposal the corpus of plays found in the Corpus del espanol escrito con marcas de oralidad project (CEEMO) is presented as the initial project of an instructional sequencing design having the translation of the textual genre of theater to address linguistic variation as its main focus.


The main objective of the present article is to shed some lights on teacher training education programme in the context of three Muslim countries namely Islam Republic of Afghanistan, Islamic Republic of Iran and Islamic Republic of Pakistan
after reviewing some relevant erstwhile studies. The findings reveal that all countries under the study are under resourced particularly Afghanistan followed by Pakistan. However, in Afghanistan over all education system is miserable comparing to the education system to the other studies in particular and region in general. Alongside,
economic, cultural and social problems cannot be ignored. In the light of findings of this study, it is suggested that the policy makers of all three countries should plan appropriate and right policy in order to promote education. It is further advised that adequate teacher training must be arranged to prepare skilled and proficient
teacher which will consequently improve student performances. Sound policies will not only help to achieve the Millennium Development Goal but will certainly play decisive role in the enhanced level of socio and economic conditions of these countries.


The paper deals with the computation of distribution network com- ponents reliability parameters. Knowledge of the component reliability parame- ters in power networks is necessary for the reliability computation and also for reliability-centered maintenance system. Component reliability parameters are possible to retrieve only with accurate databases of distribution companies. Such a database includes records of outages and interruptions in power net- works. The main problem for an analysis of these databases is the heterogeneity feature: databases of various distributors differ from one another. It is impossi- ble to retrieve reliability parameters from this data in a direct way. In this paper, we introduce a framework which enables the retrieval of parameters from vari- ous databases. We apply this framework for the retrieving of parameters from outage data in the Czech and Slovak republics. There are also actual results.


To the Editor:— After reading the article by Parisi and Kaplan ( 194 : 298,1965) describing apnea, muscle weakness, and ptosis in association with colistimethate therapy, we feel obligated to caution physicians that neuromuscular effects due to this drug may be quite common. We recently saw a patient who repeatedly developed episodes of ptosis and profound muscular weakness of the extremities in response to small doses (75 mg every 12 hours) of sodium colistimethate. Her renal function was normal, and the maximum blood level of the drug was 2μgm/ml. This value is within or below the recommended therapeutic range. Edrophonium, 10 mg, administered intravenously improved her extremity weakness, but had no effect on her facial weakness. Fortunately, toxicity due to the colistimethate was considered, and she became asymptomatic when the antibiotic was discontinued. It is conceivable that had this patient received the customary dose of the drug (300 mg), or had there


Resumen en: This article presents a synthesis of Paul Valery is analysis vindicating the importance of intellect, form, and creativity in the representation of real...


Genome editing is a generic term for new methods enabling targeted modifications to the genetic material (genome) of a cell. The CRISPR/Cas9 method in particular holds great promise for new application methods. The German Federal Institute for Risk Assessment (BfR) systematically monitors these developments in the interest of consumer health protection. In this FAQ, the BfR answers the most important questions on the topic of genome editing and the CRISPR/Cas9 method in particular.


The present invention provides a stabilized with reduced spontaneous generation of reagents in methods to enable simultaneous quantitative determination of LDL cholesterol and total cholesterol by a single measurement. In the present invention, the biological sample is a method for the determination of total cholesterol and cholesterol of low density lipoproteins in the measurement once, the first step and the first to process the lipoproteins other than of the biological sample low-density lipoproteins, and generating hydrogen peroxide and the hydrogen peroxide generated by processing the low density lipoprotein remaining hydrogen peroxide obtained in the step and simultaneously call the quinone dye and a second step of calling a quinone dye in the first step without the formation of quinone dye occurs, the second the total cholesterol and cholesterol of low density lipoproteins from the amount of a quinone pigment produced in the process provides a method for quantitative measurement of a time. Lipoproteins, cholesterol, hydrogen peroxide, anthraquinone dye


Objective To detect genetic toxicity of Chinese drug Arnebia decoction in adult and fetal mice. Methods Micronucleus test was employed on adult mice of bone marrow cells and fetal mice of hepatocytes. Results The frequency of micronucleated polychromatic erythrocytes on adult and pregnant mice were (3 8±1 0) ‰ and (3 8±1 4) ‰ respectively,after gastric perfusion of Arnebia decoction in dosage of 1 0 g/kg.There was no significant difference in comparison with negative control groups (t 1=0 9,t 2=2 1,P0 05).But significant micronucleus induction at the higher dose of 5 0 g/kg,10 0 g/kg and 20 0 g/kg were showed on adult and pregnant mice (7 1±1 8) ‰,(8 8±2 2) ‰,(9 3±1 8) ‰.Respectively compared with the negative controls (t 1=5 8,t 2=9 7,t 3=8 4,P0 01). Conclusion A genotoxic potential of Arnebia decoction was demonstrated in our study and was dose related.It should be aware the effects in clinical practice especially among pregnant population.


[ABSTRACT] It is considered that olfactory stimulation by fragrance inhalation is one of the methods of relaxation. We examined the possibility by using fragrance inhalation essential oils, such as sweet orange oil and peppermint oil. We measured salivary alpha-amylase activity and state anxiety levels in undergraduate students before and after inhalation. Salivary alpha-amylase activity levels have been utilized to assess the sympathetic nervous activity. Our results indicate that both salivary alphaamylase activity and state anxiety levels are significantly reduced after fragrance inhalation of the sweet orange oil. Consequently, our research suggests that sweet orange essential oil has a relaxation effect.


Construction of subregional urban models requires knowledge of the relationships between activity levels and the spatial structure of urban systems. Covariance procedures are used to identify associations between population change and urban hierarchies, fields, and core-periphery structures in southern Ontario. Over three time periods, from 1941 to 1971, the hierarchical variable shows little explanatory power, although this does not preclude the possibility of hierarchical impulses operating within the decade spans of these data. Autocorrelation in the rates of change damps out over distance, but there are significant regional variations. In the two decades of slower but steady growth, covariances are high and distance damping is spatially homogeneous. However, in the fast growth era of the nineteen-fifties core-periphery contrasts are heightened, local heterogeneity increases outside the core region, and patterns of population change reflect metropolitan influence fields.