Introduction In recent years many different bearingless motor concepts (cf. [1] and [2]) have been presented, where the radial position of the rotor can be regulated with active magnetic forces during standstill and rotation. They have gained a lot of attractiveness for various applications due to their many advantages such as no friction losses, ultra-high cleanness and compact dimensions. On the other hand, the price of these benefits is an increased effort in the power and control electronics, which are needed for the precise and fast regulation of the rotor position. Typically, the control electronics contain a digital signal processor unit (DSP) which processes the sensor signals, determines the motor state and calculates an optimal output of the bearing power electronics. While in the past the possibilities of low-cost DSPs have been relatively poor, nowadays DSPs with great possibilities including a very high clock-frequency, several integrated analog-to-digital-converters, integrated pulse-width modulation (PWM) generation, preassigned trigonometric functions and a large available internal memory are provided from various companies. These high-end DSPs allow exploring more advanced control algorithms, which have not been possible to implement so far.


Objective To study the value of 256-slice spiral CT angiography of carotid(CTA) in diagnosing ischemic cerebrovascular disease.Methods The clinical data of 100 TIA(transient ischemia attrack)patients and 100 carotid atherosclerosis patients were retrospectively analyzed,all the cases were underwent multi-slice spiral CT angiography(MSCTA),and observation of the distribution and character of carotid artery atherosclerosis and the extent of stenosis and the morphological changes of intracerebral arteries and the formation of collateral circulation with transverse axial planar reconstruction,volume rendering(VR),multiplanar reconstruction(MPR),curved planar reconstruction(CPR) and maximun intensity projection(MIP).Results In the 100 cases of TIA,non-calcified atherosclerotic plaque was 23%(30/128),mild to moderate stenosis 85%(68/80),severe stenosis 15%(12/80,with single stenosis,at all);in 100 cases of carotid atherosclerosis,non-calcified atherosclerotic plaque 40%(70/174),mild to moderate stenosis 72%(98/136),severe stenosis 28%(38/136,with double stenosis in 3 cases);in the control group: the detection rate of plaque in the cerebral infarction group,the ratio of non-calcified atherosclerotic plaque and the incidence of the severe stenosis or occlusion of cariotid artery increased,the difference between two groups was statistically significant(P0.05).Conclusion The difference of the extent of carotid atherosclerosis between TIA and carotid atherosclerosis groups is statistically significant,256 CTA can diagnose the features of plaque,the extent of artery stenosis and the formation of collateral circulation correctly that have an important value in prevention,treatment and prognosis judge of ischemic cerebrovascular disease.


We study in this paper the design and efficiency of compiler algorithms that remove ownership overhead in shared-memory multiprocessors with write-invalidate protocols. These algorithms detect loads followed by stores to the same address. Such loads are marked and constitute a hint to the cache to obtain an exclusive copy of the block. We consider three algorithms where the first one focuses on load-store sequences within each basic block of code and the other two analyse the existence of load-store sequences across basic blocks at the intra-procedural level. Since the dataflow analysis we adopt is a trivial variation of live-variable analysis, the algorithms are easily incorporated into a compiler.
Through detailed simulations of a cache-coherent NUMA architecture using five scientific parallel benchmark programs, we find that the algorithms are capable of removing over 95% of the separate ownership acquisitions. Moreover, we also find that even the simplest algorithm is comparable in efficiency with previously proposed hardware-based adaptive cache coherence protocols to attack the same problem.


Purpose
The purpose of this paper is to investigate the effect of lanthana (La2O3) on the mechanical and tribological properties of polyimide (PI).

Design/methodology/approach
The mechanical and tribological properties of PI nanocomposites filled with La2O3 were studied by molecular dynamic simulations to explore the deep mechanisms from an atomic or molecular view.

Findings
The results showed that the hardness of the PI matrix increased after La2O3 modification with a decrease of 72.4% nanoindentation depth. Besides, the friction coefficient of PI decreased by 72.2% after filling La2O3, and the shear deformation was largely reduced under the same conditions. The adsorption effect of La2O3 on the PI molecular, which reduced the atomic relative concentration, velocity, interaction with counterpart Fe layer and the temperature rise in the frictional interface, contributed to the improvement of the mechanical and tribological performance.

Originality/value
This study reveals the friction and wear mechanism of PI composites filled with rare earth oxide at the nanoscale.


Existing evidence on international migration based primarily on the experiences of males indicates that returnees are seldom carriers of lasting social change. This study explores the extent to which women contribute to change either in the family realm or in the broader social system which has not been documented. Quantitative data were collected from 80 women living in the US in 1983 who returned to their home towns as single unaccompanied adults or spouses. 2 rural towns on the outskirts of Guadalajara Mexico were used as field sites. Cooperative familial roles between husbands and wives are characteristic while in the US but on return to Mexico spouses once again shift to parallel roles where spouses seek support from same sex peers. Seasonal migration and hence continual resettlement alter womens life styles as they move form 1 culture to the other. This experience of "double lives" is most accentuated among working women. Moving from a dual to a single paycheck family from permeable to rigid family roles and from a complementary to a segregated marital relationship requires readjustment. Womens economic contribution through remittances or investments appears to be marginal. Their earnings are small and merely enhance family purchasing power abroad. Since opportunities for female work in rural Mexico are so limited women are seldom able to apply new techniques in the work place. Women migrants however act as powerful role models for other women who see temporary migration as a way out of poverty. Behavior patterns that seem to distinguish migrants from non- migrants are new hair styles modern clothes makeup increased personal hygiene and more concern about health.


The sputtering technique is largely used for the deposition of thin layers. In this study, the Monte Carlo (MC) method combined with the binary collision theory of hard spheres is used to simulate the energy, direction and topology of the film deposit. The effects of several parameters such as the substrate, target, pressure and the distance between substrate and target were analyzed. Our results showed that for large pressures or distances, energy and angular distributions are uniform and consequently the obtained film will be uniform. The obtained results are in agreement with other works, which validates our calculations.


The objective of this work is to describe how two teachers use grammatical terminology in English as foreign language classes, to understand the teachers' reasons to use or to avoid metalanguage, and to identify what influenced their behavior. The results reveal that grammar teaching is present in both English classes observed. The difference was on the use or avoidance of the grammatical terms. The teachers' actions were based on cognitive, contextual and experiential factors. The factor that influenced most their classroom decisions was their experiences as L1 and FL students.


The biaxially oriented film has a larger vertical orientation (MDO) ratio and 2.0 or less in the transverse direction orientation (TDO) ratio than 1.2, MDO ratio greater than TDO ratio, the film is a block copolymer There comprises a polymer composition comprising a first high impact polystyrene (HIPS) component grafted to a polystyrene, a rubber-like conjugated diene content 1-7 wt% of the first HIPS weight basis, gel concentration There was less than 10 wt%, an average rubber particle size is 1~0.01Myuemu, have about 40 to about 90% by volume diameter of less than about 0.4μm of the rubber particles, and from about 10 to about of the rubber particles have a diameter of 60 vol% is about 0.4 to about 2.5 [mu] m, a majority of the rubber particles have a core / shell morphology, the concentration of the first HIPS component is 30-100 mass of the total polymer composition weight percent occupied, Beam-like diene is 1 to 5 mass% based on total polymer composition weight. The film also based on total polymer composition weight, general-purpose polystyrene to 70 wt%, and may contain up to 20 wt% of different second HIPS component from the first HIPS component. The polymer composition accounts for at least 95 wt% of the film, the remaining film mass is additive.


Abstract Porcine pancreatic lipase was modified with Z‐proline via the constitution of amide bonds between the free amino groups of lipase and the carboxyl groups of Z‐proline, which were activated by 1‐ethyl‐3‐(3‐dimethylaminopropyl)‐carbodiimide (EDC). Different amounts of Z‐proline were bound to lipase. Modification degree was determined by 2,4,6‐trinitrobenzene sulphonic acid (TNBS), by means of the decrease in free amino groups on lipase. The reason for choosing Z‐proline was its unique structural characteristics, protected amino groups, and its effect on protein conformation by reducing the flexibility of the lipase molecule, thus achieving stabilization against changes in pH and temperature. After the modification, porcine pancreatic lipase was found to have new physicochemical characteristics, such as optimum alkaline pH stability and thermal stability at elevated temperatures.


In vitro antibacterial activity of methanol extract of whole plant (leave, stem, flower & root) of Achyranthesbidentata were found to be the most effective against the bacterial strains Bacillus cereus, Salmonella typhi, Streptococcus pyogens, Escherichia coli and Pseudomonas aeruginosa. The maximum zone of inhibition of achyranthesbidentata extract was 10 mm against Bacillus cereus at the dose of 100 μg/disc. A qualitative phytochemical analysis was performed for the detection of Reducing Sugars, Carbohydrate, Saponins, Alkaloids, Flavonoids, Tannins, Gums, Steroid and Glycosides. The photochemical of flavonoids, tannins and alkaloids show antimicrobial activity and saponin may be attributed to anti-infecting agent where flavonoids showed antimicrobial activity by complexing with cell wall and also binds to adhesions. The present study is done to evaluate the antibacterial efficacy of achyranthesbidentata against several pathogenic bacterial strains which could be further exploited for isolation and characterization of the novel phytochemicals in the treatment of infectious disease especially in light of the emergence of drug-resistant microorganisms and the need to produce more effective antimicrobial agents.


The lack of vocabulary is the main problem for the Chinese language learner when they go on to the intermediate and advanced study.To solve the problem,this article studies the features of Four-Character Chinese Structure and its status in Chinese language while discussing the unique significance of Four-Character Chinese Structure in teaching Chinese as a foreign language.The author puts forward the viewpoint of making good use of Four-Character Chinese Structure to help the Chinese language learners to master the words and enlarge their vocabulary.The author also points out that Four-Character Chinese Structure is the difficulty for the learners as it has many connotations and cultural implications.


Abstract We compared two attenuated anticoccidial vaccines, administered to broilers by spray into the incubator (88,000 males and 210,100 females). Vaccine A container five species of Eimeria and vaccine B three. Zootechnical performance was similar in the two groups, with mean lesion scores no higher than 1; vaccine A caused only duodenal lesions, while vaccine B also caused typhlitis. Maximum oocyst count was 23,000/g feces at age 28 days with vaccine A and 38,000 at 21 days with vaccine B. Broilers vaccinated with vaccine B had more frequent enteric symptoms, and C. perfringens isolation.


Does gross or net debt matter for long-term sovereign spreads in emerging markets? The topic is important for undestanding the borrowing cost implications of public assetliability management decisions (e.g. using assets to lower debt). We investigate this question using data on emerging market economies (EMEs) over the period 1998–2014. We find that both gross debt and assets have a significant impact on long-term sovereign bond spreads in emerging markets, with effects roughly offsetting each other (coefficients of opposite sign and similar magnitude). Hence, net debt seems more appropriate than gross debt when evaluating the impact of indebtedness on spreads. The empirical results suggest that an increase in net debt by 10 percentage points of GDP implies an increase in the spread by 100–120 basis points, and the effect is larger during periods of domestic distress. The key results from this empirical study are quite robust to alternative specifications and subgroups of EMEs.


This paper presents a review of the realm of medicinal applications of Inonotus obliquus raw materials, sterile conks I. obliquus, based on the bibliographies of chemical studies of the fungus. The experimental part of the paper is devoted to the presentation of methods of estimating the resource potential of this fungus based on data obtained in the comfort zone of ththis species. A new form, I. obliquus f. sterilis, is formally described.


The present kinematic and dynamic analysis of large-scale strike-slip faults, which enabled the formation of a collage of Altai terranes as a result of two collisional events. The Late Devonian–Early Carboniferous collision of the Gondwana-derived AltaiMongolian terrane and the Siberian continent resulted in the formation of the Charysh–Terekta system of dextral strike-slip faults and later the Kurai and Kuznetsk–Teletsk–Bashkauss sinistral strike-slip faults. The Late Carboniferous–Permian collision of the Siberian and Kazakhstan continents resulted in the formation of the Chara, Irtysh and North-East sinistral strike-slip zones. The age of deformation of both collisional events becomes younger toward the inner areas of the Siberian continent. In the same direction the amount of displacement of strike-slip faulting decreases from several thousand to several hundred kilometers. The width of the Late Paleozoic zone of deformation reaches 1500 km. These events deformed the accretion-collision continental margins and their primary paleogeographic pattern. q 2003 Elsevier Ltd. All rights reserved.


Pseudohypoparathyroidism (PHP) is a heterogenous group of disorders characterized by hypocalcaemia, hyperphosphataemia, increased serum concentration of parathyroid hormone (PTH) and insensitivity to biological activity of PTH. It is considered as one of the rare diseases (ORD) by the National Institute of Health in the United States(1-3). Based on clinical, biochemical and molecular genetics findings, variable forms of this disorder were reported. Convulsions due to hypocalcaemia can be misdiagnosed and treated as epilepsy. We report for the first time from Sudan a case of a rare variant of this disorder (PHP type Ib) who was initially misdiagnosed and managed as epilepsy and eventually developed one of the complications of this disorder i.e. intracerebral calcifications and became epileptic. Corresponding author : Gaffar Ibn Auf Children Hospital Khartoum Sudan, firstname.lastname@example.com


This study aimed at evaluating changes in the clinical and echocardiographic parameters of pregnant sheep, as well as the HRV indexes due to the physiological alterations that happen at this stage implicating in high maternal metabolic demands. For this purpose, the study evaluated 10 Dorper sheep through their pregnancy, starting from the second month until the day before birth, conducting clinical, echocardiographic and electrocardiographic examinations focused on the HRV. The echocardiogram was conducted in a doppler ultrasound device with a multifrequency sectorial transducer in bidimensional mode. The HRV indexes were obtained through the Televet 100® system. There were increases in the thickness of the interventricular septum during diastole starting from the third month, and in the internal diameter of the left ventricle during systole and diastole at the second and third months, while the ejection fraction increased as the pregnancy progressed. The size of the left atrium increased starting at the second month. The SDNN, RMSSD and PNN50 HRV indexes were higher at the fifth month of pregnancy and after delivery. There were no significant differences in the frequency-domain HRV indexes during pregnancy. The gestation leads to alterations in the clinical parameters and the activity of the autonomic nervous system.


DNA-topoisomerases are ubiquitous enzymes essential for major cellular processes. In recent years, interest in DNA-topoisomerases has increased not only because of their crucial role in promoting DNA replication and transcription processes, but also because they are the target of numerous active ingredients. The possibility of exploiting for therapeutic purposes the blocking of the activity of these enzymes has led to the development of a new class of anticancer agents capable of inducing apoptosis of tumor cells following DNA damage and its failure to repair.


Esculetin is a phenolic compound that is found in various natural plant products and induces apoptosis in several types of human cancer cells. However, the underlying mechanisms of its action are not completely understood. In the present work a phytochemical study of ethyl acetate extracted from the aerial parts of Euphorbia guyoniana plant endemic of Algeria, led to the isolation of a compound (esculetin). The purification of this compound was by column chromatography and TLC. The (...)


This collection examines the work of the Italian economist and social theorist Vilfredo Pareto, highlighting the extraordinary scope of his thought, which covers a vast range of academic disciplines. The volume underlines the enduring and contemporary relevance of Pareto's ideas on a bewildering variety of topics; while illuminating his attempt to unite different disciplines, such as history and sociology, in his quest for a 'holistic' understanding of society. Bringing together the world's leading experts on Pareto, this collection will be of interest to scholars working in the fields of sociology and social psychology, monetary theory and risk analysis, philosophy and intellectual history, and political science and rhetoric.


This paper investigates optical orthogonal frequency division multiplexing (O-OFDM) systems with index modulation (IM) based on discrete Hartley transform (DHT) for visible light communications (VLC). An interesting trade-off between spectral efficiency (SE), energy efficiency, peak-to-average power ratio (PAPR) and bit error rate (BER) performance can be made by using the IM technique. And the DHT-based O-OFDM-IM systems can achieve higher SE compared with the DFT (discrete Fourier transform)-based counterparts. Employing DHT instead of DFT enables the removal of the Hermitian symmetry requirement, which contributes to transmitting more index bits and results in SE improvement. To acquire the same SE, the proposed systems can significantly lower the constellation order leading to better BER performance by contrast with the DFT-based counterparts. We employ DC (direct current) biasing and AC (Asymmetrically clipped) techniques to investigate the O-OFDM-IM systems in this paper. Simulation results indicate that SNR gains can be obtained by the DHT-based DCO/ACO-IM in comparison to the DFT-based counterparts. We also propose a novel reduced-complexity ML (maximum likelihood) detector specifically applicable to VLC. The new detector exhibits the same BER performance as the ML detector and performs better than the LLR (log-likelihood ratio) detector with reduced computational complexity.


Caesar's Civil War is an unfinished masterpiece. It was abandoned by an author who found himself living in a different world than that which saw its commencement. A snapshot of the late republic, it offers a vivid and detailed account of the troubled Roman empire near the turn to the common era. In it, Caesar recounts his break with the Senate and general Pompey and narrates the events of the nineteen months of civil war that followed. It ends after general Pompey's death, amidst the lead up to the Alexandrian war that initiated the next phase of the fight for Rome. The work shows the brilliance for which Caesar's oratory, like his generalship, was known. The primary topics covered in this introduction to Caesar's gripping history are the generic background of Caesar's commentarii or "Notebooks," his criteria for selection of material, the contemporary context of the civil war, the literary techniques employed, and the work's characterization and structure. General aids to the reader include maps to accompany the particular events discussed, a timeline of the civil war and of Caesar's life, explanation of technical terms, and a glossary.


Human lymphocytes isolated from adult peripheral blood and cord blood, tonsils, adenoids and spleens were analysed for Fc receptors for IgE (FcE) by rosette assays. The FcE+ cells were also characterized for their class of surface immunoglobulin (sIg), complement receptors, receptors for sheep erythrocytes (E), and Helix pomatia A haemagglutinin (HP), and their abilities to phagocytoze and adhere. The average number of FcE+ cells was in adult peripheral blood 1.2±0.4%, in cord blood 3.0±1.3%, in tonsils 4.2±5.2%, in adenoids 5.8±4.2%, and in spleens varied from 0.8% to 15.8% among individual patients. Overnight culturing of the lymphocytes under conditions that allowed detection of Fc receptors for IgM (Fcμ) usually lowered the number of FcE+ cells. Neuraminidase treatment caused no change. Rosette formation was inhibited by IgE myeloma proteins and their Fc fragments, but not by mildly reduced and alkylated and heated (56°C) IgE, indicating that the receptors are specific for the native configuration of the IgE Fc fragment. Double cell surface marker analyses with fluoresceinated F(ab')2 fragments of purified anti‐μ, δ, and γ antibodies used to label the FcE rosette‐forming lymphocytes from peripheral adult and cord blood showed that 50–80% were sIgM+ but only 0–28% were sIgD+. In contrast, approximately 80% of the FcE+ cells from tonsils, adenoids and spleens were sIgM+ and sIgD+. The FcE+ lymphocytes represented 10–20% of the sIgM+ lymphocytes in both the peripheral adult and cord blood. Depletion and enrichment experiments indicated that most of the FcE+ cells bear complement receptors. Lymphocytes having both E and FcE receptors were not found. Furthermore, the lymphocytes with HP receptors, a marker for T cells and immature B cells, were FcE−. Monocytes and neutrophil granulocytes did not form FcE rosettes. These data indicate that a minor population of human B lymphocytes have FcE receptors. The majority of the FcE+ lymphocytes in the blood differ from those in tonsils, adenoids and spleen in that the majority of the former are sIgM+/sIgD− and the latter sIgM+/sIgD+. The sIgM+/sIgD− FcE+ cells in the blood are probably relatively mature lymphocytes since they lacked HP receptors, which are found on immature B cells


Transition metal based complexes that exhibit nuclease activity have garnered interest due to their chemotherapeutic applications. Cisplatin has been regarded as one of the most effective drugs, however toxicities and drug resistance has limited its clinical use. Copper (II) centered complexes are promising due to the importance of copper for a range of physiological processes, including enzyme and protein activity. Copper is also found in high concentrations in tumor cells as it is needed for angiogenesis. We have synthesized and characterized several copper complexes that are derived from a thiazole ligand backbone that express nuclease activity: [Cu(8OHQ(oBt))Cl2] and [Cu(8OQ)(oBt))Cl(MeOH)]. These complexes contain step‐wise structural modifications allowing structure function comparisons to be made. DNA cleavage and binding studies were carried out using gel electrophoresis, ethidium bromide, and UV‐Vis Spectroscopy. Quantitative analyses from each of the above studies were used to assess nuclease efficiency, binding efficiency and the copper compounds' interaction with DNA and BSA.


The derivation of effective interface Hamiltonians on the basis of an underlying noncritical bulk order-parameter theory is critically examined for use in studying critical wetting transitions in (d=3)-dimensional systems with short-range forces. A crossing constraint on the interfacial profile is used to define the fluctuating interface location l(y) and exact general expressions are obtained for the effective wall-interface potential W[l(y)] and for the wall-modified interfacial stiffness Σ[l(y)] in terms of a constrained planar order-parameter profile. Previous discussions in the literature are shown to be inadequate


Treating a Class III malocclusion has always been a challenge to the clinician beginning with the proper diagnosis, treatment options and the time of treatment. Few are of the opinion that the malocclusion should be corrected as soon as it is noticed while others prefer to wait it out till late mixed dentition or permanent dentition. However there only a few willing to take the middle path and hence correcting this malocclusion during early mixed dentition period utilizing the optimal growth potential of the growing orofacial musculature. This article describes a Hawleys appliance with anterior expansion screw to correct anterior cross bite in pseudo Class III malocclusion with permanent dentition in a patient who could not afford fixed orthodontic therapy.


Vitruvius' report that Caryae in Arcadia supported the Persians is credible in the context of other instances of anti-Spartan sentiment in the Peloponnesus.


When a flexible arm is rotated by a motor about an axis through the arm's fixed end, transverse vibration may occur. The motor torque should be controlled in such a way that the motor rotates by a specified angle, while simultaneously stabilizing vibration of the flexible arm so that it is arrested at the end of rotation. In this paper, the authors propose deterministic and adaptive control laws for one-link flexible arm. Using the fact that matrix dD(/spl delta/)/dt-2C(/spl theta/, /spl theta//spl dot/, /spl delta/, /spl delta//spl dot/) is skew symmetric, controllers which have a simplified structure with less computational burden are proposed by using Lyapunov stability theory.


Reliable measurement of cellular cytotoxicity is essential for the characterization of immune responses and for the monitoring of antibody treatment efficacy. Until now, the standard 51Cr‐release assay has remained the sole sensitive assay that measures cellular cytotoxicity. Alternative non‐radioactive assays have been developed but they do not provide accurate measurement of target cell cytotoxicity. The cost and hazard of handling radioactivity are strong incentives to find alternative solutions to 51Cr. We took advantage of the recent development of cell‐imaging multimode readers to develop a novel non‐radioactive and real‐time cytotoxic assay that demonstrates good reproducibility and sensitivity. The extent of target‐cell cytotoxicity is monitored over time by imaging and quantifying live fluorescent target cells in 96‐well plates. We have developed classical natural killer cell assays in the presence or absence of blocking antibodies and antibody‐dependent cell‐mediated cytotoxicity. We show that in these assays, cell killing occurs within the first 2 hr with half maximum killing reached after 30 min. This technology has numerous applications such as natural killer and T‐cell cytotoxicity assays and can be extended to cell survival and apoptosis measurement assays.


Published admissions standards typically include factors such as test scores, grades, and letters of recommendation. Yet there is little direct evidence in the literature on how these criteria as well as race and sex are actually utilized in student selection. That is, what are the operative rules in admissions decisions? This study reports the results of a survey of the National Association of Schools of Public Affairs and Administration principal representatives. Each respondent was presented an applicant profile booklet designed to estimate the impact of grades, GRE scores, references, race, and gender on admission decisions. In the findings we discuss how these variables are considered in the selection process. The analysis concludes with a commentary on the implications of the data for Master of Public Administration programs, and their admissions practices.


This article is one of a number of reviews in the special issue of the Journal of Inorganic and Organometallic Polymers and Materials, celebrating the 50th anniversary of the discovery of metallocene-based polymers. Since the first examples of polyferrocenes in 1955, research into the design of organometallic polymers has grown exponentially. Organoiron polymers have incorporated ferrocene and arene cyclopentadienyl complexes, and have been developed for materials, liquid crystals, and electrocatalysts. The focus of this review is on the synthesis, properties, and characterization of macromolecules based on ferrocene or arene cyclopentadienyliron cations. Ferrocene-based polymers in which the ferrocene moieties are in or pendent to the backbone are described, as well as, the use of arene cyclopentadienyliron complexes in the design of polymeric materials. The design of star-shaped macromolecules and dendrimer materials that contain ferrocene and/or arene cyclopentadienyliron units will be discussed as well.


In this study cross-spectral methods are used to test the hypothesis that inventory investment leads sales of merchant wholesalers through the short-term, seasonal frequencies, but sales lead inventories through the long-term, cyclical frequencies. An intuitive explanation and a time-domain, generating model for the reversal phenomenon are given.


This empirical study examined the association between social work students' ratings of teaching ability and several course, student, and instructor variables. Over 5,000 standardized evaluation forms rating instructors' specific skills and overall effectiveness were collected between 1991-93 at a school of social work in a large urban university. The results showed strong positive relationships between ratings of teaching effectiveness and ratings of skills reflecting course organization, rapport with students, and fair grading. This study supports the legitimacy of student ratings in assessing faculty, and the authors discuss implications for faculty development of the strong relationship between effective teaching and organizational skills.


Background: Taiwan is located in a subtropical area where there are approximately 50 kinds of land snakes and six principal kinds of venous snakes. Snakebite envenomation is not an uncommon issue in Taiwan. We design a study to obtain an understanding of the characteristics of snakebites and snakebite patients in a medical center in northern Taiwan. Materials and Methods: This was a retrospective medical records study of an 8-year period. We used the key word "snake" to search the emergency department (ED) diagnosis of all patients and then used antivenom management codes to select patients for inclusion. The species of snake involved, time and site of the bite, geographic data of the patients and patient outcomes were recorded. Results: In total, there were 125 snakebite patients (male 70%, female 30%). The snakes involved were Protobothrops mucrosquamatus (50%), followed by Trimeresurus stejnegeri (7%). The feet and ankles were the most frequently bitten areas (42.4%). The peak months were July and October. The average ED stasis time was 2 hours and 45 minutes, and 65.6% of snakebite patients received antivenom. In patients bitten by P. mucrosquamatus, there was a high surgical rate, 23.8% higher than those reported in other studies. No mortalities or side effects of antivenom were reported in these patients. Conclusion: We propose a clinical flow chart for physicians who are treating patients bitten by P. mucrosquamatus. Snakebites, especially those inflicted by P. mucrosquamatus, induce severe soft tissue swelling, which can mimic compartment syndrome. Antivenom for P. mucrosquamatus is the first and only choice of treatment. The amount of antivenom needs to match the clinical symptoms. Patients bitten by P. mucrosquamatus may need longer observation times than patients bitten by other species of snakes, in addition to toxicologist consultations, sonographic examinations, and measurement of the objective compartment pressure before surgery.


The aim of our work was to investigate the testicular differentiation mechanism in true hermaphrodites with karyotype XX in order to study the SRY gene and Y heterochromatic region (Yql2-Yqter) by PCR (Polymerase chain Reaction) in these patients and another gonadal patologies. A total of 10 patients were studied: 8 Trues Hermaphrodites (TH): 6 46,XX, 1 45.X/46,XY and 1 45,X/46XY/46,Xinv (Y); a female with Swyer's syndrome 46,XY and 1 Dysgenetic Male pseudohermaphrodite 46,Xr (Y). The SRY gene was present in TH X/XY, X/XY/Xinv (Y) and DMP Xr (Y); it was absent in 6 XXTH and XY female. The Y heterochromatic region was amplified in TH X/XY, X/XY/Xinv (Y) and XY female, and without amplification in THXX and DMP Xr (Y). These results suggest that XXTH could have arisen by an autosomic gene involved in sex reversal or the SRY gene could have been lost in the early stages of embrionary development. The absence of testes and female phenotype in the XY female could be explained by the absence of the SRY gene because of an Y chromosome deletion in the paternal gametogenesis. These data illustaste the usefulness of PCR in the molecular analysis of these patients.


Simple, sensitive and specific spectrophotometric method was developed and validated for quantification of nebivolol in tablet dosage form. Drug showed the absorption maxima in THF at 301nm and was linear for a range of 5-60mcg/ml with a correlation coefficient of 0.9999. The validation of the above method was done by carrying out precision and accuracy studies. The limit of detection and Limit of Quantification for nebivolol was found to be 0.82mcg/ml and 2.76mcg/ml. The percentage recovery was found to be 99.3% and showed good repeatability with relative standard deviation less than 2. So, the proposed method can be applied for the routine analysis of nebivolol from formulations.


AbstractThis paper shows an approach that is useful for evaluating the resistance to flows in narrow open channels. A series of experiments were first carried out in a smooth, rectangular, open channel for which the aspect ratio varied from 0.12 to 1.53. Experimental data collected were then used to validate a resistance formula that was proposed previously by modifying Prandtl's friction law.


It is shown that a non-periodic Kronig-Penney model exhibits mobility edges if the positions of the scatterers are correlated at long distances. An analytical expression for the energy-dependent localization length is derived for weak disorder in terms of the real-space correlators defining the structural disorder in these systems. We also present an algorithm to construct a non-periodic but correlated sequence exhibiting desired mobility edges. This result could be used to construct window filters in electronic, acoustic, or photonic non-periodic structures. It is shown that a non-periodic Kronig-Penney model exhibits mobility edges if the positions of the scatterers are correlated at long distances. An analytical expression for the energy-dependent localization length is derived for weak disorder in terms of the real-space correlators de(cid:12)ning the structural disorder in these systems. We also present an algorithm to construct a non-periodic but correlated sequence exhibiting desired mobility edges. This result could be used to construct window (cid:12)lters in electronic, acoustic, or photonic non-periodic structures. Kronig-Penney model used to the characteristics of electrons in a periodic potential, as this model provides one with perhaps the of Bloch states. This model is also used to provide estimates of the bandwidths in semiconductor superlattices with high reliability. The model its superlattices an of the of quasi-periodic systems,


We show how to detect duplicates in a sequence of k n-bit vectors presented as a list of single-bit changes between consecutive vectors, in O((n + k) log n) time. Problem We are given a sequence S = {v1, . . . , vk} of k n-bit vectors, presented as follows: The first bit vector is all zeros and each subsequent vector vi is obtained from the previous vector vi−1 by flipping a single bit in position bi, 0 ≤ bi < n. S is represented as b2, b3, . . . , bk. The problem is to detect duplicates in the sequence v1, v2, . . . , vk. More formally, we seek a labeling S → {1, . . . , k}, vi 7→ ci, such that ci = cj iff vi = vj . Solution Without loss of generality in the remainder of this note we assume that n is a power of two. Let T be the perfectly balanced binary tree on n leaves. We number the leaves of T from 0 to n− 1 and associate each with a bit position. Each interior node x of T is similarly associated with a block B(x) of consecutive bit positions corresponding to the leaves of the subtree rooted at x. For a bit vector vi, let vi(x) be its substring in B(x). The idea behind our data structure is simple: each node x has an associated data structure that stores implicitly the set ⋃k i=1{vi(x)}. The data structure stored at node x consists of two arrays Dx and Fx that store the following data: • Dx[1, . . . , dx] contains the sorted set including 1 and all distinct values i, 1 < i ≤ k, such that vi−1(x) 6= vi(x). • Fx[1, . . . , dx] contains integers in the range 1, . . . , dx with the property that Fx[i] = Fx[j] iff vDx[i](x) = vDx[j](x). 1Research supported in part by NSF ITR Grant CCR-0081964 and by a grant from US-Israel Binational Science Foundation; part of work has been carried out while visiting MaxPlanck-Institut für Informatik. Department of Computer and Information Science, Polytechnic University, 5 MetroTech Center, Brooklyn, NY 11201 USA; http://cis.poly.edu/ ̃aronov. 2Research supported in part by NSF grant CCF-0430849. Department of Computer and Information Science, Polytechnic University, 5 MetroTech Center, Brooklyn, NY 11201 USA; http://john.poly.edu. We now complete the description of our algorithm, by explaining how to initialize Dz and Fz for all leaves z ∈ T and how to compute Dx and Fx from Dl, Fr, Dl, Fr for any internal node x with children l and r. Froot describes the desired labeling of S, since Droot contains all the numbers 1, . . . , k. If one stores all of the leaves z in an array in numerical order, a linear scan of the sequence b2, b3, . . . , bk of bit updates allows one to initialize arrays Dz and Fz, for all z. Specifically, we store the current bit vector vi−1 explicitly in a bit array V [0, . . . , n − 1]. Since bi = j indicates a bit flip in position z = j (recall that bit positions, and thus leaves are identified with integers 0, . . . , n− 1), we flip the value of V [j], add j to Dz, and depending on the resulting value of V [j], set the next entry in Fz to zero or one. Algorithm 1 The pseudocode for computing Dx, Fx from Dl, Fl, Dr, Fr. 1: i← j ← k ← 1 2: Dl[dl + 1]← DR[dr + 1]←∞ 3: repeat 4: Px[k]← (Fr(i), Fl(j), k, 0) 5: if Dl[i] < Dr[j] then 6: Dx[k]← Dl[i]; i← i + 1 7: else if Dl[i] = Dr[j] then 8: Dx[k]← Dl[i]; i← i + 1; j ← j + 1; 9: else if Dl[i] > Dr[j] then 10: Dx[k]← Dr[j]; j ← j + 1; 11: end if 12: k ← k + 1; 13: until i = dl + 1 and j = dr + 1 14: dx ← k − 1 . dx is the length of Px and Dx 15: Sort Px lexicographically on the first two fields, by radix sort 16: for k ← 2 to dx do 17: if Px[k − 1][1] = Px[k][1] and Px[k − 1][2] = Px[k][2] then 18: Px[k][4]← Px[k − 1][4] 19: else 20: Px[k][4]← Px[k − 1][4] + 1 21: end if 22: end for 23: for k ← 1 to dx do 24: Fx[Px[k][3]]← Px[k][4] 25: end for Now, we describe, for an internal node x of T with children l and r, how to construct Dx, Fx from arrays Dl, Dr, Fl, Fr; see Algorithm 1. The new sorted array Dx[1, . . . , dx] is built by merging the arrays Dl and Dr, eliminating any duplicates, in time O(dl + dr) =


The utility model discloses an electric power tool storage cabinet, which comprises a cabinet body. A sealing door is arranged on the cabinet body, and a plurality of layers of classifying unit functional squares are arranged inside the cabinet body. Each classifying unit functional square layer comprises at least one classifying unit functional square, and the outer end face of each classifying unit functional square is provided with a label. The inner side of the sealing door is provided with a plurality of hooks for hanging articles, and the lower end of the cabinet body is provided with a support for preventing articles from being damped. The outer end face of each classifying unit functional square is provided with a label, names and service life of electric power tools are written on labels, and accordingly users are reminded all the time not to use overdue electric power tools, thereby greatly facilitating the safe utilization. The electric power tool storage cabinet is low in cost, reasonable in design, safe and convenient in use, and facilitates the long-term storage and effective management of electric power tools.


Abstract.The article explores a new type of catalysis - electric field catalysis. The laws of field catalysis are given. The characteristics of the electric field are determined, which set the values of the characteristics of the field catalysis. Field catalysis and field catalyst do not fit into the traditional definition of catalysis and catalyst, which may require a revision of the terminology of catalysis. The field is a more versatile catalyst compared to material catalysts, both in terms of its application to a wider range of chemical reactions, and in the ability to control the rate and selectivity. It is shown that a common donor-acceptor mechanism of catalysis is realized in heterogeneous and field catalysis. Generalized formulas are obtained, from which, as partial results, the laws of heterogeneous and field catalysis follow. New definitions of catalyst and field catalysis are given. The class of material catalysts has been expanded and supplemented with field catalysts.


1 The evidence for κ‐receptor heterogeneity is equivocal. We have now investigated this question by comparing the effects of five putatively selective κ‐agonists. The parameters examined were: the relative potencies in depressing hindlimb flexor muscle reflexes to noxious pinch stimuli in both spinalized and sham‐spinalized rats; the reversibility of these effects by naloxone; and the effects on blood pressure. 2 Two types of drug effect was discriminated. One drug group, represented by U‐50,488, U‐69,593 and PD‐117,302, had a potency ratio between sham and spinalized rats approximately 10 fold lower than the other group, which comprised GR103545 and CI‐977. 3 Under sham‐spinalized conditions, CI‐977 and GR103545 at high doses caused only sub‐maximal reductions of spinal reflexes. U‐50,488 was still active when superimposed on these high doses of GR103545. 4 Naloxone reversed all effects, but different doses were required between compounds, with GR103545 taking some 20 times higher doses of naloxone to cause reversal than did U‐50,488. 5 The effects on mean arterial pressure were opposite between groups. 6 The results imply that more than one type of naloxone‐sensitive non‐μ opioid receptor must be involved in mediating these complex actions of ligands that have been claimed to be selective for κ‐receptors.


The creep deformation regular of birch and basswood LVL was studided.Through three-point bending creep test,under 40%,50%,60% ultimate strength stress level.The results showed that the creep deformation had obviously the correlation of stress level.At the same time,under the different stress levels.The discontinuities and long-term trends of the creep deformation was discussed.


ABSTRACT Although the notion of involving families in residential treatment is not new, relatively little research has specifically examined youth perceptions of improvement in family functioning as an outcome of adolescent residential treatment. This study investigated youth perceptions of family functioning (as measured by the Family Adaptability and Cohesion Evaluation Scales-III and indicated via the Circumplex Model) at admission and after at least 5 months of treatment. Posttest results specify significant perceptual improvement with families that indicated functional challenges per the Circumplex Model, and family functioning was maintained for youth (baseline) perceiving of their families as healthy.


................................................................................................................
  xii RESUMO
  ..................................................................................................................
  xv SCOPE
  AND
  CONTEXT
  ............................................................................................
  xviii THESIS
  OUTLINE
  ......................................................................................................
  xix CHAPTER
  I
  -‐
  Introduction
  ...........................................................................................
  1 CHAPTER
  II
  –
  General
  and
  Specific
  Aims
  ..................................................................
  22 CHAPTER
  III
  –
  Brief
  Methodology
  ............................................................................
  24 CHAPTER
  IV
  –
  Research
  work:
  Results
  .....................................................................
  31 Section
  I
  –
  Part
  I
  ......................................................................................................
  33 Section
  I
  –
  Part
  II
  .....................................................................................................
  43 Section
  I
  –
  Part
  III
  ....................................................................................................
  59 Section
  II
  –
  Part
  IV
  ...................................................................................................
  81 Section
  II
  –
  Part
  V
  ..................................................................................................
  101 Section
  II
  –
  Part
  VI
  .................................................................................................
  122 CHAPTER
  V
  -‐
  Discussion
  .........................................................................................
  143 CHAPTER
  VI
  -‐
  Conclusion
  and
  a
  Perspective
  for
  Future
  Research
  ...........................
  154 CHAPTER
  VII
  –
  References
  .....................................................................................
  157


According to World Health Organization, most of the people primarily depend on plants for their health care needs. Adhatoda Vasica, commonly known as 'Adusa' and Bacopa Monnieri, commonly called as 'Brahmi' are renowned for its various effects in medical care for centuries. This study was carried out to screen qualitatively the presence of phytochemicals in the leaf extracts of the medicinal plants, Adhatoda vasica and Bacopa monnieri. Various solvents such as acetone, methanol, ethanol and water were used to extract the leaves and the presence of phytochemicals varies with the polarity of solvents. The study revealed the presence of phytochemicals such as alkaloids, saponins, tannins, flavonoids, etc thereby, supported the use of leaves of both plants in traditional medicine. Thus this study showed that these plants can be used as a significant source for the development of drugs of definite actions.


We study the rhythmogenesis of oscillatory patterns emerging in network motifs composed of inhibitory coupled tonic spiking neurons represented by the Plant model of R15 nerve cells. Such motifs are argued to be used as building blocks for a larger central pattern generator network controlling swim locomotion of sea slug Melibe leonina.


The authors made a review of the diagnostic difficulties in meningoencephalitis by the Criptococcus neoformans, in vivo, today easier by special methods such as China ink and culture in the CSF. From their diagnosed 14 cases, 2 have been treated by Amphotericin B. The first was a chronic case with acute episodes which were less severe when Amphotericin B was used. This case has been alive for 20 months. The second case was an acute one with clinical and spinal fluid normalization and has a follow-up of 11 months. In both cases Amphotericin was used intravenously (50 mg in 500 ml of a solution of glycose at 5%) in the first case 4 series and in the second case 2 series. There were no complications. The authors consider that the use of Amphotericin B has given those cases a better prognosis.


During plasma assisted film deposition (PAD), the ion energy available per film atom plays an important role in film growth and morphology development. Consequently, it influences the film properties such as stress, adhesion, and dc resistivity. Calculation of the ion energy available per film atom is a little difficult in PAD because of a lack of data on the flux and energy distribution of ions (IED) incident on the film during deposition. In this article, the nature of the IED, in a rf ion plating system used for Cu film deposition, is determined with the help of a theoretical model available in literature and the plasma parameters obtained from Langmuir probe data. Then the ion energy available per Cu film atom (ECu) is calculated to be in the range of 0.5–5 eV/atom. This is further used to explain the variation of film morphology and dc resistivity with the ion plating process variables, viz., pressure, Cu evaporation rate and substrate bias. This range of ECu is insufficient to influence the film thi...


Insights into traveller's behavior are important for the Tourism Authority of Thailand to draw up plans and make decisions to manage and promote their capital city (Bangkok) as a tourism hub. Therefore, the objective of this paper is to obtain a comprehensive understanding of traveller's behavior in Bangkok. To achieve this, we used a variety of methods such as activity, temporal, and spatial analysis to identify visitor patterns in Bangkok by utilizing a relatively new data gathering technique to extract social media check-in data. The findings include comprehensive statistics about traveller's behavioral patterns at these spots that have practical implications in various city management applications.


Abstract Gastrointestinal tract is a series of hollow organs connected in a long tube twisting from the mouth to the anus. Recovery of gastrointestinal diseased patients depends on the early diagnosis of the disease and proper treatment. In recent years, the diagnosis of gastrointestinal tract diseases using endoscopic image classification has become an active area of research in the biomedical domain. However, previous studies show that there is a need for improvement as some classes are more difficult to identify than others. In this study, we propose a concatenated neural network model by concatenating the extracted features of VGGNet and InceptionNet networks to develop a gastrointestinal disease diagnosis model. The deep convolutional neural networks VGGNet and InceptionNet are trained and used to extract features from the given endoscopic images. These extracted features are then concatenated and classified using machine learning classification techniques (Softmax, k-Nearest Neighbor, Random Forest, and Support Vector Machine). Among these techniques, support vector machine (SVM) achieved the best performance compared to others, using the available standard dataset. The proposed model achieves a classification accuracy of 98% and Matthews's Correlation Coefficient of 97.8%, which is a significant improvement over previous techniques and other neural network architectures.


The thesis revives the historical importance of a small, relatively obscure Australian workfare policy through a marxist theoretical framework that is equally marginal to Australian social policy analytics. The Jobs, Education and Training Program (JET) w


Litter size manipulation results in body weight gain alterations, such phenotype remains until the adulthood. Several studies have demonstrated the importance of the angiotensin II (ANGII) in the obesity development, as well as its correlation with cardiovascular diseases. Using the model of reduction or enhance the litter size, this work aimed to investigate the alterations in plasma and adipose ANGII concentrations in rats. The litters were divided into 3 groups: Normal Litter (NL, 10 pups), Small Litter (SL, 3 pups) and Large Litter (LL, 16 pups). The reduction and enhance of the litter size, led to an increase and decrease of the weight gaining in SL (~25%) and LL (~19%) groups, respectively, at the weaning (21st day) till adulthood (60th day). Plasma ANGII levels were higher in both SL (~40%) and LL (~120%) groups in relation to the NL at the weaning. We have also observed a significant rise in the ANGII levels in epididymal and retroperitoneal white adipose tissue (~40%) in LL group in relation to NL group at the weaning. On the other hand, there was a significant enhancing in the ANGII concentration in the interscapular brown adipose tissue in the SL group in relation to NL at weaning (~25%) and adulthood (~200%). Our results show that the litter size manipulation can program not only the weight gain but also the renin‐angiotensin system activity in plasma and adipose tissue.


We investigated all-optical flip-flop operations with AND-gate functionality by injecting data and set inputs with different wavelengths to a 1.55-μm polarization bistable vertical-cavity surface-emitting laser. Control of the phase difference between the two inputs is not needed for stable operation, which differs from the same wavelength case we have used thus far. Thus, this proposed method will simplify all-optical signal processing systems. The wavelength difference dependencies of the switching power and the timing jitter of the polarization switching were measured for 1-ns data pulses. For 2GHz wavelength difference, the data (set) pulse power was about −20 (−14) dBm and the timing jitter was about 110 ps. The BER was about 8 × 10−3.


Juridical relief is the last guarantee of the implement of rights, and shareholder's suit is the most important way of protection of shareholders' rights and losses-retrieve. Shareholder's Direct Lawsuit System and Shareholder's representative Suit Systems are two indispensably forms of integrated shareholder's suit system. There are some limitations in the provision of Shareholder's Direct Suit in The Company Law of our country, and there is no provision about the Shareholder's Representative Suit. It's a very important question for discussion problem to set up the system that can be composed of direct lawsuit and indirect lawsuit adapted the situation of our country, the task is that the legislation of corporation law should resolve in our country.


In this paper, a numerical study to assess the dosimetry of an in vitro exposure setup at the intermediate frequencies (IF) is presented and validated. The setup is able to reproduce any complex magnetic induction (B) field waveform using a couple of square coils. In our work, actual signals generated by a 1.5 T magnetic resonance imaging (MRI) apparatus were exploited. Firstly, the simulated B-field time flow within the empty coils was compared with B-field time flow B measured in proximity of an MRI gantry. A good agreement was found thus validating the numerical model. For dosimetry, the weighted peak method, according to ICNIRP 2010 guidelines was applied considering the computed electric (E) field induced in a standard Petri dish. The compliance to the reference limits is respected both for workers and general public as well as for local (central nervous system, CNS) and whole body exposures. Hence, the presented numerical model and the weighted peak index calculation presented in this work, can provide further insight to evaluate exposure to complex field waveforms. Dosimetric evaluations on different biological sample holders (i.e flask, tube) are also under investigation.


We show a case of endophthalmitis presenting 7 weeks after intravitreal aflibercept injection. An unusual species of viridans streptococci, S. intermedius, was isolated. The case highlights the need to consider infection even in cases of very delayed-onset postinjection inflammation, and the potential wide variability in severity of Streptococcus viridans endophthalmitis. Purpose: Endophthalmitis following intravitreal anti–vascular endothelial growth factor injections is frequently caused by Streptococcus viridans organisms and tends to be aggressive. Herein, we present a case of postinjection Streptococcus viridans endophthalmitis presenting in an atypically delayed fashion with good visual outcome. Methods: Single clinical case report. Results: A 91-year-old woman treated with aflibercept for exudative age-related macular degeneration of the left eye presented to the emergency department with mild pain and visual acuity decline to counting fingers, pigmented anterior chamber cells and vitreous haze 7 weeks after her most recent intravitreal injection. She had no symptoms of systemic infection. The presumptive diagnosis initially was vitreous hemorrhage. Over 10 days of observation, she developed worsening pain and vitritis suggestive of endophthalmitis, leading us to perform vitrectomy with intravitreal vancomycin and ceftazidime. Vitreous biopsy was culture positive for Streptococcus intermedius, a type of viridans streptococcus typically associated with head and neck abscesses. The infection resolved and the patient's visual acuity returned to her baseline of 20/100, with no recurrence of infection after 4 months of follow-up. Conclussion: The virulence of viridans streptococci capable of producing postinjection endophthalmitis may vary widely. Infection ought to be suspected even in cases of delayed-onset intraocular inflammation.


A new photothermal system designed for the metrology and characterization of thin metal films is described. This system employs a new technology based on the precise scanning of the thermal-wave field by varying the pump-probe beam offset distance. The resulting set of photomodulated reflectance signal amplitude and phase offset scans recorded at multiple modulation frequencies is processed using an appropriate theoretical model to obtain the parameters of the wafer under study.


Objective: We examined whether children (8-11 years) diagnosed with Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) or AttentionDeficit/Hyperactivity Disorder (ADHD) showing primarily hyperactive behavior, differed in selective attention and working memory (WM) abilities. Methods: Healthy controls and children with ADHD, PDD-NOS or symptoms of both disorders (PDD/HD) (n=15 in each group) carried out a visual selective memory search task while their EEG was recorded from which event-related potentials were derived. Results: Compared to the control group, all patient groups made more omissions while hyperactive children also exhibited more false alarms. Regarding the process of WM-controlled search, significant group differences in ERP data were found between the control group and each of the clinical groups. Conclusions: The results point to less efficient WM-functioning in all patient groups. Whereas the clinical groups differed from each other at the behavioral level as measured by questionnaires, no distinction between the clinical groups could be made with respect to performance or ERP measures of WM capacity and selective attention. Significance: The results suggest that a possible differentiation in selectivity and working memory capacities between PDD-NOS and ADHD is hard to find. This may agree with clinical practice, where differential diagnosis is a subject of discussion. ERPs in Children with ADHD and/or PDD-NOS


For a given finite set of nonuniformly or irregularly sampled data, we present a new approach based on sparse signal representation (SSR) framework for their spectral analysis, which is capable of significantly achieving a higher resolution over the various existing methods: Schuster periodogram and iterative adaptive approach (IAA). In this paper, the observed data of nonuniformly sampling can be cast as a single measurement vector (SMV) model via over complete sparse signal representation, and then the spectrum is estimated by recovering a sparse vector. The simulation results confirm the efficacy of this proposed approach.


Western Ghats of India is one of the megadiversity centres in the world. There are 15 species of Garcinia reported of which many are endemic in nature. The genetic diversity in one of the same endemic species Garcinia xanthochymus was evaluated using ISSR and RAPD markers. A total of 15 individual plants from each location was analyzed. Six populations of G. xanthochymus were collected and screened using 16 ISSR and 10 RAPD markers. ISSR primers generated 80 bands of which 17 were polymorphic (21.25 % polymorphism) and RAPD primers produced 51 total bands of which 18 were polymorphic (35.29 % polymorphism). The ISSR and RAPD cluster analysis grouped them into two groups. The detected polymorphism is enough at species level and therefore the RAPD and ISSR can be used as efficient markers for genetic relatedness assessment in G. xanthochymus. The UPGMA and PCoA analysis distantly grouped these populations in two groups. The genetic diversity within the population is an important to source for the evolution of the genera. G. xanthochymus has distinct populations in different geographical area.


A novel dosing system for fuel borne catalyst (FBC), used to assist regeneration with a diesel particulate filter (DPF), has been developed. The system was designed for on-board vehicle use to overcome problems encountered with batch dosing systems. Important design features were simplicity, to minimise system cost, and the use of in-line dosing rather than batch dosing linked to tank refuelling. The paper describes the development of the dosing system which continuously doses FBC into the fuel line feeding the engine injection pump. The theoretical considerations behind the concept are explored, together with the realities imposed by fuelling regimes in which a variable proportion of the fuel flowing through the injection pump is passed back to the fuel tank. Two types of system are considered, ie where 1) FBC is added to the fuel in direct proportion to the flow rate of fuel and 2) FBC is added at a constant time-based rate. Modelling of changes in the concentration of FBC in the fuel over time indicated significant non-linearity with both approaches. Bed testing with a diesel engine equipped with a DPF assessed both flow-based and time-based dosing concepts. The test work demonstrated that the in-line FBC dosing concept could achieve reliable regeneration with either system. The averaging effect of soot accumulation over time on the ratio of metal to soot within the DPF apparently accounts for successful regeneration despite big variations in FBC concentration. The paper describes the application of the system to light duty vehicles such as Black Cabs used in central London. Data loggers indicated successful operation on several vehicles over distances ranging from 12,000 to 20,000km. An in-line FBC dosing system was also fitted to a heavy duty fire appliance support vehicle for additional tests. Data to date suggest that this application has produced acceptable DPF regeneration performance. Test work on this vehicle continues.


The purposes of this study were to explore the connection of the Body Mass Index, Exercise Participation, and Sleep Quality with the Reference to Elementary School Students. This research is to investigate the senior graders of Fongming elementary schools in Yingge Township as objects which were issued the questionnaires to collect the required information. Based on convenience sampling in this research, there were 200 questionnaires distributed and a total of 179 of valid samples were collected. Therefore the valid return rate was 89.5% The collected data were analyzed with descriptive statistic, independent sample t-test, and one-way ANOVA, Scheffes' method, and Pearson product-moment correlation. The results indicated that:1. There was significant difference on the overall Exercise Participation between different genders of Elementary School Students Ex. the boys' Exercise Participation is superior to the girls. However, Body Mass Index made no obvious difference to the overall Exercise Participation. 2. There was no significant difference on the overall Sleep Quality between different genders of Elementary School Students. The different Body Mass Index caused the significant difference on the overall Exercise Participation Ex. the over fat Elementary School Students get worse sleep quality. 3. There was no reference with Exercise Participation and Body Mass Index on Elementary School Students.


Background:
 Social determinants of health have an important influence on health equity. Addressing them appropriately is essential to improve population health outcomes and decrease health care disparities. We aimed to compare data from two nationwide cohorts from the US to analyze the shift of cardiovascular risk burden and major adverse cardiac and cerebrovascular events (MACCE) in low-household income (LHI) groups.

 Methods:
 Adult admissions among patients from LHI (0-25th) quartile were identified from two cohorts in 2007 and 2017 using the National Inpatient Sample. Socio-demographics, and pre-existing cardiovascular/extra-cardiovascular comorbidities were compared between the cohorts and multivariable regression was performed to assess the risk of MACCE (all-cause mortality, acute myocardial infarction and cardiac arrest including ventricular tachyarrhythmias) in 2017 vs. 2007 cohort.

 Results:
 Hospitalizations among LHI quartile showed 12% relative increase in 2017 (N=10,680,030) as compared to 2007(N=9,510,877). The 2017 cohort was younger (mean age 57 to 54 years) and admissions among male patients increased from 39% to 43.6% between 2007 and 2017. Also, non-elective and Medicaid admissions increased from 74% to 81% and 21% to 32%, respectively in 2017. Traditional CVD risk factors and comorbidities in the LHI quartile increased in 2017 compared to 2007 cohort (Table 1). The risk of composite MACCE was higher in the 2017 cohort compared to 2007 cohort (7.2% vs 6.7%, adjusted OR 1.03, 95%CI:1.03-1.04, p<0.001). Although the hospital stay was comparable (3 days), hospitalization charges increased in 2017.

 Conclusion:
 Comparative analysis of LHI admissions across a decade shows that increasingly younger, male, non-white patients get hospitalized for non-elective reasons and have a higher burden of CVD risk factors and MACCE in 2017 vs. 2007. This warrants preventive strides to curtail CVD burden in patients of the LHI and improve health outcomes.


This paper consists of two parts. The first part discusses commonsense knowledge about events as manifested in language. Three kinds of knowledge are identified: compositional, durational, and aspectual. Compositional knowledge concerns internal structuring of events into preparatory, initial, main (the body), final, and resulting stages. Durational knowledge concerns durational relations between events and stages of the same event. Durational knowledge can be expressed as qualitative dependencies among the parameters of the event and as its time scale. The notion of time scale is introduced and related to shared cyclical events (time units).In discussing aspectual knowledge three notions are distinguished: aspect as a grammatical category of the verb, implemented by affixes, auxiliaries, and such; aspectual class, which is a characteristic of a lexical meaning; and the aspectual perspective of the sentence determined by the position of the Reference Time (RT) with respect to the event described by a finite clause. I argue that an aspectual classification of situations evolving in time should be based on such considerations as the kinds of resources they consume and the goals they achieve. A detailed classification of instantaneous and noninstantaneous events is developed.The second part of the paper discusses how this knowledge is employed in understanding extended narratives. Temporal discontinuities, in conjunction with other kinds of discontinuities identified in the paper, signal boundaries between discourse segments; within each segment, all three varieties of temporal knowledge help establish the temporal relations among narrated events.


This article aims to promote the integration of knowledge and life based on a phenomenological description of sexuality and erotic relations. To carry out this task, I will follow the approaches of the French philosopher Michel Henry in order to extract the anthropological consequences of a phenomenology of incarnation pertaining to sexuality. Both the peculiar union produced by the sexual act and its perpetually threatened condition through the "event" of nihilation of the flesh will be the object of reflection throughout this work. In my search for the reintegration of the human being through the sexual act, I will show the importance of woman and her spiritual superiority in deepening the intimate meaning of sexuality. Further, I will argue that the intersubjective experience lived in sexual practice demands a consideration of human beings from their ultimate condition of relational possibility (Life), emphasizing their engendered, not merely created, condition. Thus, the salvation of human beings and their involvement in the coming of Life to them is intrinsically related to that carnal disposition which aids to unify them, beyond their diversity, in their self-revelation in Life.


ABSTRACT We start from, and expand on, a basic insight in negative dialectic, namely, that our main concern should be with the absolute worst in political life. We then consider how this might have an impact on the way we understand the role and grounds of moral equality. Subsequently, we move on to explain the importance of decency in political morality. Finally, we take a closer look to basic data about global poverty and inequality and what these might tell us in light of our analysis of the foundations of moral equality and its relationship to social cruelty.


New method for the magnetic encephalography data analysis was proposed. The method transforms multichannel time series into the spatial structure of the human brain activity.
 In this paper we further develop this method to determine the dominant direction of the electrical sources of brain activity at each node of the calculation grid. We have considered
 the experimental data, obtained with three 275-channel magnetic encephalographs in New York University, McGill University and Montreal University. The human alpha rhythm phenomenon
 was selected as a model object. Magnetic encephalograms of the brain spontaneous activity were registered for 5-7 minutes in magnetically shielded room. Detailed multichannel
 spectra were obtained by the Fourier transform of the whole time series. For all spectral components, the inverse problem was solved in elementary current dipole model and the
 functional structure of the brain activity was calculated in the frequency band 8-12 Hz. In order to estimate the local activity direction, at the each node of calculation grid
 the vector of the inverse problem solution was selected, having the maximal spectral power. So, the 3D-map of the brain activity vector field was produced – the directional functional
 tomogram. Such maps were generated for 15 subjects and some common patterns were revealed in the directions of the alpha rhythm elementary sources. The proposed method can be used
 to study the local properties of the brain activity in any spectral band and in any brain compartment.


A 62-year-old male farmer presented to our clinic with eruption and mild itching on the right hand. He stated that this eruption had begun 15 days previously and that he had presented to the local general practitioner. Dermatological examination revealed a lesion containing maculopapules approximately 6x7 cm in size on the dorsum of the right hand with mild margin activation and a very few occasional red squamae. Dermatophyte infection was primarily suspected. We learned from anamnesis that the drug previously administered was clobetasol dipropionate, raising the possibility of tinea incognito (TI). Native preparate was performed from the squamae on the lesion. Fungal hyphae were observed at microscopic examination. In describing this case diagnosed as TI, we wish to emphasize that specimens should be taken for microscopic examination with KOH in patients with a similar clinical appearance at differential diagnosis, and that treatment should be administered accordingly.


The democratic-reconstruction measures that were employed in Afghanistan following the USled invasion in late 2001 were riddled with problems, one of which related to the composition of the new government. The inclusion of warlords in the nation-building process, although it made strategic sense for the fledgling government, resulted in the reproduction of cycles of violence and was particularly detrimental to the interests of women, whose supposed liberation was at the centre of the War on Terror discourse. This paper examines this phenomenon through the eyes of Malalai Joya, who, in her memoir A Woman Among Warlords provides an insightful account of the radical, misogynist warlords who occupied positions of power in the newly formed government. As a young female politician in a historically male domain, Joya is a rare voice of resistance against her government and the American military. In raising her voice against the power holders, Joya subverts the dominant narrative of the war, especially pertaining to the liberation of Afghan women. She argues that by colluding with the warlords, the US and the Karzai administration were complicit in allowing violence to continue in political and social spheres. This paper argues that the US-led invasion largely failed to make any concrete ideological transformation and instead aided the reestablishment of oppressive power structures, especially in Afghanistan's provinces.


It is now a truism of art history that new methodologies parallel new art movements. Jacob Burckhardt's amazingly detailed, non-hierarchical history of the Italian Renaissance, in which fashions are on a par with city feuds and processions with timeless altarpieces is echoed in the Impressionists' emphasis on daily life in France. Wilhelm Worringer's Abstraction and Empathy, it has often been remarked, bears striking similarities to Die Brucke's reliance on the tribal arts discovered by Ernst Ludwig Kirchner in ethnographic museums. Similarly, Henri Focillon's prose poem The Life of Forms in Art, a Bergsonian affirmation of vitalism manifested in trailing sensuous rhythms, is contemporaneous, in its English translation, with the formative years of the Abstract Expressionists and parallels their belief in the power of paint to communicate and reveal the most profound aspects of existence.


In this article, the achievement of a uniform elastic contact pressure in a frictionless, keyless, shaft–hub interference fit obtained by properly shaping the mating profiles is examined. The peculiarity of the hub mechanical response according to which, under the effect of a uniform pressure applied to the hub bore, the bore axial profile moves radially without any distortion, is exploited to simplify the determination of the mating profiles that return a uniform pressure. In particular, the hub radial deflection may be computed with a simple plane model, whereas only the shaft radial deflection requires a more complex analysis in cylindrical coordinates. Explicit approximate expressions are reported for the shapes to be conferred to the mating profiles to achieve a uniform pressure. Selected examples are presented to clarify the proposed design procedure and to preliminarily explore the effect on the pressure profile of simple shape errors.


SnO2/PI composite films were composed with ployimide as substrate and SnCl2 as precurosor via surface modification and ion-exchange method.The optimal preparation conditions were discussed.And the morphology,structure of the composite films were characterized by SEM-EDS,ATR-FTIR and XRD.The photocatalytic activity ware evaluated by photocatalytic degradation of the concentration loss of MB.The photocatalyst degradation rate of MB was 98.6%after 6h.


Small-amount border trade with North Korea has made significant contribution to the economic growth of Dandong.It can be concluded that one percentage rate increase of export and import can bring about 0.6 percentage increase of local GDP.And with the same magnitude of increase in export or import,the GDP will rise 0.575% and 0.846% respectively.


Trauma is known as a key health issue around the world that affects patients in both developed and developing countries and accounts for 10 000 deaths every day. Injury occurs abruptly and unexpectedly and traumatic injuries are the main causes of mortality and disability globally that affects young, healthy, and productive persons. In 2010, a total of 180,811 deaths were classified as injury-related in the US. According to the Global Burden of disease injuries caused 5.1 million deaths, 9.6% of all mortality in 2010. In 2013, trauma was also estimated for 11% of disability-adjusted lifeyears (DALYs). The World Health Organization (WHO) estimated that road accidents would be third leading cause of death globally by 2020.


In this 3-year study, an attempt was made to establish life tables and population structure models at four sites of the only mangrove species recorded for the area, Avicennia marina. Some of the sites showed clumped patterns of distribution, there were regular patterns of distribution on the east coast and random patterns on the west coast. The population flux reflected different growth-stage capacities at the selected sites. Survivorship curves were Type I (probability of death increasing with age) for all populations except for one record of Type III (probability of death decreasing with age) on the east coast. The data suggest that A. marina is not endangered in this region, despite the arid conditions.


Solar flares are of great fundamental and practical interest. In some events the energy release might exceed 1026 J Tsurutani et al. (2003) and accompanying CME courses extremely severe magnetic storm. Because of very rare occurrence of such global flares a laboratory simulation appears to be an alternative that could provide experimental data necessary for physical understanding of this phenomenon and for verifying theoretical models. Flare involves processes on many widely varying spatial and time scales. In laboratory only some parts of the whole evolution could be attempted for simulation. The present work is focused on the last stage of eruption when a magnetic loop filled with heated plasma is ejected away from the Sun, either itself or pushed by an upcoming jet. The geometry of a flare loop suggests that a magnetic dipole and laser-produced plasma could be used to simulate this structure Nikitin & Ponomarenko (1995). In the present work similarity criteria that relate laboratory parameters to the natural phenomena, experimental set up and preliminary results are presented.


In this paper, we present a group-level happiness intensity estimation approach based on convolutional neural networks. First, Multi-task Cascaded Convolutional Networks (MTCNN) are applied to detect all faces in the image. Then, the face-level happiness intensity of each detected individual face is respectively predicted by using a deep convolutional neural network with transfer learning from pre-trained VGGFace model. Finally, the weighted average of face-level happiness intensities for all detected faces in the group is used to estimate the happiness intensity of a group of people in the image. Experimental results on validation dataset of HAPPEI database demonstrate that the proposed method has promising performance, which is 0.58 in terms of Root Mean Square Error (RMSE), and outperforms the baseline approach that uses the CENsus TRansform hISTogram (CENTRIST) descriptor and Support Vector Regression with a non-linear Chi-square kernel, which gives an RMSE of 0.78.


Background: Thyroid hormone is very important in regulating energy metabolism in all tissues of the human body. Thyroid dysfunction plays an important role in osteoporosis, hyperlipidemia and cardiovascular disease, all of which are associated with Human Immunodeficiency Virus (HIV) infection or therapy for HIV. Medications used to treat HIV infection are also said to be important factors that can cause thyroid abnormalities. This study aim is to see the effect of giving Antiretroviral Therapy (ART) to the thyroid function of new HIV patients in stage 1 and 2.
Method: This prospective cohort study was conducted at Medan city health center and Medan Haji Adam Malik Hospital in March-June 2019. HIV patients who met the inclusion criteria were tested for thyroid function (Ft4 and TSH) before and after 3 months on ART, BMI, routine blood, CD4 and quality of life using the SF-36 questionnaire. Data analysis used paired t test and Pearson correlation.
Result: 34 patients with stage 1 and 2 HIV showed normal thyroid function ; the average FT4 level was 1.03 ± 0.14 ng / dl and the average TSH level was 1.44 ± 0.68 µIU / mL. After 3 months of antiretroviral therapy, the mean thyroid function changes were obtained from the study subjects, where the mean FT4 results were 0.87 ± 0.13 ng / dl and the average TSH results were 1.76 ± 0.91 µIU / mL and the results were statistically significant with p 0.006 (p <0.05). There was a statistically significant relationship between TSH and CD4 levels with BMI after ART administration (p <0.05), but no statistically significant relationship was found between FT4 and BMI (p = 0.957). No statistically significant relationship was found between CD4 levels in study subjects and changes in fT4 levels (p = 0.557, r = 0.104) and TSH (p = 0.267, r = 0.196). There was also no significant difference in the quality of life of study subjects as seen from the SF-36 questionnaire both from changes in thyroid function and from CD4 levels.
Conclusion: Stage 1 and 2 HIV patients who are on ART for 3 months experienced thyroid dysfunction.


Viral ion channels are short transmembrane proteins, which have multifunctional roles in the life cycle of virus.It has been shown to form selective ion channel in host cell membrane.Some ion channel blockers are able to block the channels and inhibit the ion channels activity which may lead to diminished virus production. It suggests that the virus ion channels could be a kind of highly relevant target for antiviral drug action.


A boy, aged 5 years, was admitted to the Mayo Clinic, March 23, 1924. Early in February he had had measles. A week later he began to have pain in both ears, and at the end of four days both drums ruptured spontaneously. The right ear stopped discharging in two days and began to pain again, rupturing after a few hours. During this time the temperature was elevated somewhat, but the parents did not know how much. Mastoid pain was considerable. Both ears continued to discharge and the temperature remained high. After three weeks a bilateral mastoid operation was done; following this, chills and a septic type of temperature developed. At one time the temperature was 107.4 by rectum; it remained above 102. The child became greatly emaciated, and very intractable. The home physician wanted to give a transfusion, and operate again on the mastoids. This was refused and the


Abstract Zonal harmonic analysis has been carried out on 30-day mean pressure fields of several runs of the NCAR global circulation model (GCM): A January 6-layer case with the earth's orography; a January 6-layer case without orography; a January 12-layer case with orography; and a January 12-layer case without orography. Zonal harmonic mean waves 1, 2, and 3 from each experiment were compared between cases and with observed data. In the Northern Hemisphere below 18 km, neither the mountain (M) nor the no-mountain (NM) versions of the 6-layer January model can simulate the amplitude of waves 1 and 3 correctly when compared with observed data. The 6-layer NM case does better at simulating the amplitude of wave 2 than does the 6-layer M case. For the 12-layer version of the model, on the other hand, the M case simulated the amplitudes of waves 1 and 2 quite well in the stratosphere, while the NM case only does well with wave 2. In the Southern Hemisphere, neither the M nor NM waves in general resemble thos...


We present preconditioning strategies based on the $\mathcal{H}^{2}$-matrix arithmetic for solving dense, complex, symmetric, non-Hermitian linear systems which arise from boundary element discretizations of the Electric Field Integral Equation in electromagnetic scattering analysis. The proposed preconditioner incorporates a multilevel mechanism that offers a good balance between memory used and reduction of the number of iterations.


The present invention discloses a method and apparatus for adaptive de-interlacing, primarily to provide a simple algorithm and deinterlacing effect good adaptive de-interlacing method and apparatus. Adaptive deinterlacing method of the present invention, based on whether two images adjacent scene change occurs, the motion compensation method, respectively, and a non-motion compensation methods to compensate for de-interlacing pattern. The present invention, in the premise of ensuring the quality of the image, a certain degree of complexity of the de-interlacing reduces the complexity of the algorithms and hardware configuration.


ABSTRACT A model has an orthogonal block structure if it has, as covariance matrix, a linear combination of pairwise orthogonal projection matrices, that add up to the identity matrix. The range space of these matrices are associated to hypotheses of an orthogonal family. In this paper we show how to obtain tests for these hypotheses when normality is assumed and how to consider their relevance when normality is discarded. Besides the notion of relevance, we formulate hypotheses in a general way that may be applied to models with orthogonal block structure, whose factors may have fixed and/or random effects. The results are applied to prime basis factorial models and an example is presented.


Islamic caring was a professional behavior which a nurse had to provide nursing care based on
intellectual abilities applied to patients, families, and societies with attentive, care, friendly, empathy, polite, by using
therapeutic communication based on the Holy Qur'an and As-Sunnah. Students as prospective nurses the caregivers
who were closest to the patient in the student to provide the best service, namely caring behavior.This study aimed to
explore the factors that build Islamic caring behavior in nursing students. This study used descriptive qualitative
methods. Data retrieval used Focus Group Discussion (FGD) and in-depth interviews. Participants in this study were
from Nursing Study Program students (year I, II, and III), professional student nurses, Nursing Study Program lecturers,
hospital prescribers, and Islamic Spiritual Development hospitals around Universitas Muhamadiyah Yogyakarta and
PKU Muhammadiyah Gamping Hospital. Participants in this study were taken based on inclusion criteria. The validity
of the data used the document method and member checking. Data analysis used qualitative data processing software.
The results of this study indicate factors that build Islamic caring behavior in nursing students. This research produced
nine themes such as student's background, student's self-motivation, habituation in academic stage, internalization and
understanding of caring, role model (uswatun khasanah), religious attitudes, environment, hospital policy, changing
times. Many factors influenced students' caring behavior. These factors could be obtained from within students as well
as from the surrounding environment and students' daily exposure.


The purpose of this paper is to research wind power fluctuation character of the wind farm. First, the qualitative and quantitative analysis methods are combined. Sliding difference algorithm is used to construct wind power fluctuations evaluation system. Calculating wind power fluctuations value volatility characteristics evaluation system at different time scales, we can get the conclusion that the optimum distribution form of distributed wind power fluctuations is t-location scale. Secondly, taking into account the wind power is non-linear, non-stationary characteristics of the data signal. This feature is fully in line with the wavelet neural net data analysis features. Therefore, the choice of wavelet neural network is learning and training and testing, and thus the total power of the future wind farms are amid to predict. And the research will predictive value as new learning data, for seven days after the wind power rolling forecasts. Then, comparative analysis of single units and the whole wind turbine power fluctuation characteristics obtained differences coverage under the volatility characteristic index wind power, and further understanding of volatility characteristic of wind power. The influence of temporal and spatial distribution and other factors, single wind turbine there is a big difference between the output power fluctuation characteristics of the wind farm, which is due to the presence of different turbine wind farm suffered difference, and wake effects between units, making the distribution of the frequent fluctuations in power. With respect to a single unit-He said fluctuation entire wind farm is more gentled, that with the increase in the spatial distribution of scale, fluctuating wind power presents a certain "Gentle Effect". Finally, the analysis overcome the adverse effects of wind power fluctuations on the grid operation, prepare the following specific solutions: rational allocation of energy storage devices, expanding the coverage area of the wind farm, or to improve the design of the windmill, so that wind farms can adapt to different directions wind, and you can try to eliminate the impact of fluctuations in the energy storage device by the wind farm output power to the grid, covering the area of large wind farms can adapt to different wind power complement each other, we have reached a stable amount of purpose into the grid. Introduction With increasingly stringent resource and environmental constraints, fossil fuel-based energy development model must be a fundamental change. Wind power does not consume any fuel, can be described as clean energy. Wind from the air campaign, not because of the development of wind power and exhausted, it is a renewable energy source. Power wind turbines and wind speed main issue. Due to the impact of the wake wind between uncertainty and intermittent wind farm various units such as wind turbines based on the demand for electricity cannot be determined as a conventional power generators. Large-scale wind power base is usually required to achieve access to the grid of transmission and wind power consumptive. Random fluctuations of wind power is considered to be the main factors adversely affect the grid. Fluctuation characteristics of wind power, whether to improve wind forecasting accuracy is of great significance to overcome the adverse effects of wind power on the grid access. 2nd International Conference on Electrical, Computer Engineering and Electronics (ICECEE 2015) © 2015. The authors Published by Atlantis Press 1478 Setting up the Modeling Wind power level S-level calculated volatility index. Dynamic test data in order to eliminate random fluctuations, use the point value of the function expressed its certainty of variation, you can use level sliding difference algorithm for processing test data. Wind power fluctuation index basic formula: ( ) ( ) ( ) 5 ( 1) ( 1) 2 2 2 5


RNA-RNA junctions between hairpin loops are a common feature of RNA retroviruses, accounting for their high mechanical stability. Dimerization of Moloney Murine Leukemia Virus (MMLV) is dependent on H3 stem loop interactions, which are an example of such a junction. H3 in MMLV dimerizes via a two base pair hairpin loop enhanced by two adjacent stacking bases. All atom, explicit solvent molecular dynamics pulling simulations were performed to examine the stability of the junction. Salt concentrations and temperatures were varied and unstacking times of the flanking bases and breaking times of the kissing bonds were calculated. Survival curves revealed that increasing salt concentration, decreasing temperature, decreasing force, and having two adenine stacking bases as opposed to one guanine and one adenine stacking bases stabilizes the flanking bases of the complex. Additionally, breaking of bonds is made faster by increased temperature, pulling force, and two adenine stacking bases over one guanine and one adenine stacking bases. Increased salt decreases the breaking rate, but only at low temperatures. Simulation results were compared with single molecule optical tweezers experiments.


Maximal-entanglement entanglement-assisted quantum error-correcting codes (EAQE-CCs) can achieve the EA-hashing bound asymptotically and a higher rate and/or better noise suppression capability may be achieved by exploiting maximal entanglement. In this paper, we discussed the construction of quaternary zero radical (ZR) codes of dimension five with length n≥5. Using the obtained quaternary ZR codes, we construct many maximal-entanglement EAQECCs with very good parameters. Almost all of these EAQECCs are better than those obtained in the literature, and some of these EAQECCs are optimal codes.


Simple Summary The loss of function of the BRCA1 tumor suppressor is common in breast cancer, but experimentally, the BRCA1 inactivation promotes cell senescence. The overstimulation of RAS signaling via Her2 upregulation is also common in breast cancer, yet it can also lead to senescence. A significant percent of primary breast tumors exhibit both defects. So how do they overcome the senescence response to become successful tumors? Here we show that the RAS senescence effector NORE1A can complex with BRCA1 and that loss of NORE1A abrogates the senescence-inducing effects of Her2 and BRCA1 dysregulation. Database analysis shows that NORE1A loss of expression is common in primary breast tumors and correlates with BRCA1 loss in Her2+ but not Her2− cases. Abstract BRCA1 is a tumor suppressor with a complex mode of action. Hereditary mutations in BRCA1 predispose carriers to breast cancer, and spontaneous breast cancers often exhibit defects in BRCA1 expression. However, haploinsufficiency or suppression of BRCA1 expression leads to defects in DNA repair, which can induce DNA damage responses, leading to senescence. Activating mutation or overexpression of the Her2 oncoprotein are also frequent drivers of breast cancer. Yet, over-activation of Her2, working through the RAS oncoprotein, can also induce senescence. It is thought that additional defects in the p53 and Rb tumor suppressor machinery must occur in such tumors to allow an escape from senescence, thus permitting tumor development. Although BRCA1 mutant breast cancers are usually Her2 negative, a significant percentage of Her2 positive tumors also lose their expression of BRCA1. Such Her2+/BRCA1− tumors might be expected to have a particularly high senescence barrier to overcome. An important RAS senescence effector is the protein NORE1A, which can modulate both p53 and Rb. It is an essential senescence effector of the RAS oncoprotein, and it is often downregulated in breast tumors by promotor methylation. Here we show that NORE1A forms a Her2/RAS regulated, endogenous complex with BRCA1 at sites of replication fork arrest. Suppression of NORE1A blocks senescence induction caused by BRCA1 inactivation and Her2 activation. Thus, NORE1A forms a tumor suppressor complex with BRCA1. Its frequent epigenetic inactivation may facilitate the transformation of Her2+/BRCA1− mediated breast cancer by suppressing senescence.