Objective: The burst of COVID-19 epidemics in Italy prompted the Italian Society of Hypertension to start an observational study to explore the characteristics of the hospitalized victims of the disease. The current analysis aimed to investigate the predictors of healing among Italian COVID-19 patients. We also assessed the effect of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers on the outcome. Methods: We designed a cross-sectional, observational, multicenter, nationwide survey in Italy to explore the demographic and clinical characteristics of patients with confirmed COVID-19 infection. We analyzed information from 2446 charts of Italian patients admitted for certified COVID-19 in 27 hospitals. Healing from COVID-19 infection, defined as two consecutive negative swabs, was reported in 544 patients (22.2%), 95% of them were hospitalized. Results: Age and Charlson Comorbidity Index were significantly lower in healing compared with nonhealing patients (63 (cid:2) 15 vs. 69 (cid:2) 15 and 2 (cid:2) 2 vs. 3 (cid:2) 2, both P < 0.05). In multivariable regression model, predictors of healing were younger age (OR: 0.99; 95% CI 0.98–0.99, P ¼ 0.0001), absence of chronic kidney disease (OR: 0.35; 95% CI 0.17–0.70, P ¼ 0.003) or heart failure (OR: 0.44; 95% CI, 0.28–0.70, P ¼ 0.001). In the subgroup of patients suffering from hypertension and/or heart failure ( n ¼ 1498), no differences were observed in the use of ACE inhibitors and angiotensin receptor blockers. Conclusion: Our study demonstrated that younger age and absence of comorbidities play a major role in determining healing in patients with COVID-19. No effects of ACE inhibitors and angiotensin receptor blockers on the outcome was reported.


New technical information was presented to a medical school class divided into five groups. Group I served as controls and took the pretest before having any input. Groups II - V listened to slide-tapes presented at varying rates of speed from 114 (natural) to 250 words per minute (WPM). Comprehension was retained up to 207 WPM (83% compression) but tapered significantly at 119% compression using our technique. Subsequent rapid speaking computer compression trials enabled 200% compression (60 minutes reduced to 20 minutes) with clarity at 300 WPM. Speech compression can be employed when transmitting new technical information but is even better suited for review purposes. Students showed a 2:1 preference for compressed tapes when reviewing for exams at least in part because of a 45--67% savings in time. The applicability for continuing education programs is apparent and has been successful on a modest scale.


We present optical twin-beam squeezing from a CMOS-compatible on-chip optical parametric oscillator operating above threshold. At higher pump powers, we observe correlations among modes in the generated frequency comb.


The fast solar wind's high speeds and nonthermal features require that significant heating occurs well above the Sun's surface. Two leading theories have seemed incompatible: low-frequency Alfvénic turbulence, which transports energy outwards but struggles to explain the observed dominance of ion over electron heating; and high-frequency ion-cyclotron waves (ICWs), which explain the heating but lack an obvious source. We unify these paradigms via the novel "helicity barrier" mechanism. Using six-dimensional plasma simulations, we show that in imbalanced turbulence (as relevant to the solar wind) the helicity barrier limits electron heating by inhibiting the turbulent cascade of energy to the smallest scales. The large-scale energy grows in time to eventually generate high-frequency fluctuations from low-frequency turbulence, driving ion heating by ICWs. The resulting turbulence and ion distribution function provide a compelling match to in-situ observations from Parker Solar Probe and other spacecraft, explaining, among other features, the steep "transition range" in the magnetic spectrum.


In the last 30 years, there has been a rapid increase of Filipino parents leaving the country and their families for better job opportunities abroad. Existing literature points out the impact of migration on the families and on the well-being, academic performance, and school behaviours, family and peer relationships of the children left behind, and the need for interventions to address these concerns. A review of the literature and a survey on the current practices in schools reveals a lack of structured and programmatic interventions in school, which mental health professionals in schools recognize to be essential to help OFW children adjust better. Considering the gaps in the current practice, we recommend that more purposive school-based and family-focused psychological services are implemented to help the children and families left behind by OFW parents.


In its judgment of 16 June 2015, the Amsterdam Court of Appeal decided that media may assume that press reports published by the news agency ANP are factually correct. The case concerned two articles written by journalists of the Dutch newspaper De Telegraaf on the involvement of former directors in the bankruptcy of investment fund Partrust. The investment fund had been under investigation by the Dutch public prosecutor and the Autoriteit Financiele Markten (Financial Markets Authority - AFM) for large-scale investment fraud and undertaking a pyramid scheme for over five years


Over urban areas in Hungary, the annual average PM10 concentrations are not frequently higher than 40 μg m–3. Despite the mitigation efforts of the local governments, the annual number of exceedances of the daily limit of 50 μg m–3 is higher than what is outlined in EU Directive No 2008/50/EC. The goal of the present study is to assess the characteristics of the temporal (annual, seasonal, daily) variations in PM10 concentrations in selected Hungarian cities with large populations, where most of the exceedances have been reported. The impacts of meteorological conditions on the measured PM10 concentrations and their temporal variations are also evaluated. An important aspect of studying the trends of air pollution is that the tendencies depend not only on the emissions of certain pollutants but also on the meteorological conditions in the area of interest. To analyse emission-related trends, the meteorological signal must be removed from the data series. In this study, the Kolmogorov-Zurbenko (KZ) filter was used for this type of trend separation. Moreover, multiple nonlinear regression analysis was used to find relationships between the PM10 concentration and several meteorological parameters. The goal of this analysis is to estimate the expected daily mean PM10 concentration values. The results of this analysis demonstrate that the regression equation can provide an adequate method for PM pollution forecasting. In addition to the hourly PM10 concentrations and basic meteorological data, global radiation and boundary layer height were considered in the characterization process.


Many languages have particles that possess multiple logical functions. Take the Mandarin particle dou for example. Varying by the item it is associated with and the prosodic pattern of the environment it appears in, dou can trigger a distributivity effect, license a preverbal free choice item, or evoke an even-like inference. Considering universal grammar a simple system, we need to figure out, for a multi-functional particle, which of its functions is primary, what parametric variations are responsible for the alternations in function, and how these variations are conditioned. In this paper, I argue that the seemingly unrelated functions of dou share the same source: dou is a pre-exhaustification exhaustifier operating on sub-alternatives. Uniformly, dou affirms the truth of its propositional prejacent, negates the exhaustification of each sub-alternative, and presupposes a non-vacuity inference that there is at least one sub-alternative. Alternations in function result from minimal weakening operations on the semantics of sub-alternatives. In particular, sub-alternatives are primarily weaker alternatives, and the non-vacuity presupposition of dou yields a distributivity effect. When the semantics of sub-alternatives is weakened under particular syntactic or prosodic conditions, dou gains its other logical functions.


The present paper discusses the issue of increasing levels of multilingualism and multiculturalism, worldwide, as consequence of ongoing globalization and look at the major challenges involved in managing linguistic and cultural diversity at societal, institutional and academic level, in particular. The paper has as its major focus the Mozambican context and drawing on current research in the country and internationally on the language question, it discusses the various existing challenges and opportunities for devising an inclusive and democratic language and language education policy.


The measuring instrument gains soil humidity signal by using the moisture content sensor.After the signal of recuperating electric circuit processing,the measuring instrument gives the simulated signal that the electric circuit outputs to the A/D switch to transforms into the digital signal and sends it to the monolithic integrated circuit serial mouth expansion the LED display circuit to demonstrate the water content of soil.Thus,the survey of the moisture content of soil is intelligently realized.


Continuous-time random walks incorporate a random waiting time between random jumps. They are used in physics to model particle motion. A physically realistic rescaling uses two different time scales for the mean waiting time and the deviation from the mean. This paper derives the scaling limits for such processes. These limit processes are governed by fractional partial differential equations that may be useful in physics. A transfer theorem for weak convergence of finite-dimensional distributions of stochastic processes is also obtained.


Bubbles were simulated in a two-dimensional fluidized bed with a constant inlet velocity using two computer codes, the IIT code and the MFIX code. The computational results were compared to the Jung et al. (2005) experiments in a thin bubbling bed of 530 μm glass beads. The use of higher order numerics produces better bubble resolution due to smaller numerical diffusion. The computed bubble sizes and their distributions agreed with the experiments. The simulations show that there is no bubble formation for sufficiently elastic particles. CFD computations and previous experiments show that in the bubbling fluidized beds there exist two random oscillations. The first kind is due to random oscillations of particles and is measured by the conventional granular temperature. The second one is due to motion of bubbles and gives rise to Reynolds type stresses. It is shown that the particle granular temperature is much smaller than the bubble-like granular temperature computed from the average of the normal Reynolds stresses, measured by Cody using a shot noise technique.


This paper is concerned with an often-neglected class of NTFPs with important livelihoods dimensions, namely animals hunted for consumptive use linked to local livelihoods. For simplicity's sake, the colloquial African term 'bushmeat' is used to describe the class, despite its geographical restrictions and (for some) alleged colonial connotations. Non-consumptive uses are not considered here. The paper focuses on the question: 'Why should bushmeat be of concern to international development policy?' It is suggested that the answer is two-fold. On the one hand, the safety-net functions of bushmeat and similar forest products are crucial to the livelihoods of the poor in the humid tropics, particularly in areas with little immediate prospect of transformation out of poverty. And on the other, progress in the management of internationally high profile and emotive resources such as wildlife raises important issues in governance and may leverage broader governance benefits. The paper argues the case for the centrality of a livelihoods perspective in the development of public policy on forest governance. The paper is in three sections. The first provides a reminder of the scale of the bushmeat trade, and the conservation and welfare issues which this raises. The second examines the evidence concerning the role played by bushmeat in the livelihoods of the poor. And the third considers the potential, which exists for bushmeat to figure as a component of improved governance. The case for bushmeat as a component of development policy: issues and challenges


: The purpose of this research was to develop guidelines for designing comfortable girdles with a waist support function, such as reducing the muscle load. We conducted the following experiments : (i) measuring the electrocardiogram (ECG) and electromyogram (EMG) when using low-elastic spats with high-elastic tape and (ii) evaluating the effects of three types of trial girdles based on the results of the first experiment. During the first experiment, we developed a taping method for reducing the muscle load and sympathetic activity (psychological stress). During the second experiment, it was found that the girdle types (A, B, and C) are effective at reducing the muscle load. In particular, the Type A girdle, which placed the hard elastic fabric on the back horizontally and surrounding the ilium, provided a less compressive feeling than the others. Finally, we objectively evaluated the emotion through brain wave analysis. The Type A girdle was found to be less irritating than the regular one on the market. The results of this research confirmed that the Type A design provides a comfortable girdle with a waist support function.


Memory integration is a crucial building block of autobiographical memory. It enables us to weave individual events of our daily lives into coherent memory networks. Furthermore, it allows us to dynamically and flexibly reorganize these mnemonic networks when new information becomes available. Results from our previous fMRI study (Milivojevic et al., 2015) provided evidence for a central role of the hippocampal-prefrontal circuit in memory integration using life-like stimuli. However, while both areas are known to be involved, the contribution of individual regions and the related temporal dynamics remain unclear. In this study, we extended the life-simulating memory paradigm used in our previous studies (Milivojevic et al., 2015; Collin et al., 2015) in order to shed light on the temporal dynamics of hippocampal and prefrontal processing underlying memory integration. In a life-like narrative-insight task, we presented three seemingly unrelated events per narrative, which participants saw several times in a counterbalanced order during a pre-insight phase and a post-insight phase. Between these phases we showed a fourth event in isolation, which provided insight into which of the previously seen events belong together in a narrative and which event does not. This allowed us to track insight-triggered reconfiguration of these event networks. We extended the paradigm to include a behavioral relatedness judgment task, in which participants rated how related events were, both before and after the insight phase, for each of the 13 narratives they saw. This enables us to track the brain-behaviour relationship for each of the narratives in a within-subject design. Additionally, in order to examine hierarchical embedding of event networks into broader, across-narrative networks, we included a task designed to assess the relationship between the individual narratives. This task will give us novel insights into both behavioral and neural correlates of across-narrative integration, and extend our previous work on hierarchical memory networks (Collin et al., 2015). In addition, we optimized the paradigm to examine the temporal aspects of memory integration using MEG (data acquisition ongoing). A possible mechanism that might underlie memory integration is prefrontal-hippocampal theta coupling (Backus et al., 2016). Using representational similarity analysis, we will examine how memory integration varies on different temporal scales within and across trials. This study offers the opportunity to improve our understanding of how the human brain is able to apply prior knowledge to inform our behavior in new situations.


Objectives: To develop an energy-efficient routing protocol for Mobile Ad Hoc Network (MANET). Methods: The research work includes the Bee Colony Optimization (BCO) technique for evolving energy efficient routing algorithm. The Intelligent Cross-Layer approach based Bee Routing (ICLBR) is inspired by BCO in order to discover the optimal path for data transmission. The ICLBR Intelligent Cross Layer Approach based Bee Routing algorithm is used to overcome the congestion problem, link failure and energy loss using cross layer approach. The effectiveness of the route has been evolved with the parameter of node degree and connectivity ratio. Findings: This paper proposes an ICLBR algorithm to discover the energy efficient route in order to increase the network lifetime for MANET. The ICLBR is experimented in NS2.34, to systematically validate the routing algorithm. The experimental results show that the ICLBR improves the packet delivery ratio by 9.08% and minimizes the average end-to-end delay is by 5.16% over the Ad hoc On-Demand Distance Vector (AODV) routing protocol. Improvement: The proposed ICLBR mechanism able to enhance the network resource and also improves the network lifetime as compared to the state-of-art works.


The utility model discloses a miniature wrist watch mobile phone, belonging to the technical field of the mobile phone. The miniature wrist watch mobile phone mainly solves the problems of repetitive functions with the wrist watch and inconvenient carryover existing in the prior mobile phone. The utility model is characterized in unifying the mobile phone and the wrist watch, the pocket-sized double screen mobile phone is installed on the base of the wrist watch, the mobile phone and the base of the wrist watch are connected by prismatic grooves which are mutually geared, and a press switch which can control the inserted slippage of the mobile phone is arranged between the mobile phone and the base of the wrist watch. The structure and process of the utility model is simple, and the miniature wrist watch mobile phone is convenient for carrying and beautiful.


Yearbook for Southwest Texas State Normal School in San Marcos, Texas includes photos of and information about the school, student body, professors, and organizations, as well as some original writings and illustrations done by the students.


In order to study the validity of analytical formulas used in the calculation of characteristic physical quantities related to vacuum bubbles, we conduct several numerical simulations of bubble kinematics in the context of cosmological first-order phase transitions to determine potentially existing systematic uncertainties. By comparing with the analytical results, we obtain the following observations: (1) For the total number of bubbles, there is a 10% discrepancy between the values from simulations and from analytical prediction; (2) For the false vacuum fraction, the difference between the results from simulations and from analytical prediction is small, which, however, plays a crucial role in explaining the discrepancy observed in the total number of bubbles; (3) The bubble lifetime distribution obtained from the simulations deviates from the exponential distribution and is not obviously influenced by different nucleation rates; (4) These differences propagate into the final gravitational waves spectra, which we calculate with the sound shell model for the usually dominant contribution from sound waves, and find that the bubble number deviation enhances the peak value in the gravitational wave spectra, while the deviation in the lifetime distribution suppresses the peak value.


Leprosy is a disease to which the average American physician gives but little thought or study; he is accustomed to regard it as a foreign malady, of interest to him only as a curiosity. This is a mistake; leprosy has existed for many years in various parts of the United States, but the only recognition it has thus far received has for the most part been by dermatologists in the centers of population. The ordinary general practitioner, "the backbone of the profession," and to whom this paper is presented, is the man on whom rests the responsibility of keeping in mind the general features of the disease, and the possibility of some day encountering a case when least expected, as it is essentially a constitutional disease as much as is tuberculosis, and comes as fairly within his own domain. With us in Hawaii the disease is on the decline; thus


Amidst this uncertain situation of the Covid pandemic happening worldwide, It is necessary to protect the health workers too. Since they are more prone to the dangerous virus than any other. To reduce the risk of virus infection spreading to Health care workers, this paper proposes the concept of wearing a smart Healthwear band, an IoT monitoring device integrated with a mobile application for monitoring the patients with a contact-less mechanism. Healthware is placed on the Covid infected patients which sense the temperature, pulse, and oxygen level of the patient. This was monitored manually before with the equipment present in the hospitals. This Health wear device automatically collects the data of patients and alerts the Nurses and doctors in case of emergencies. This reduces the contact of Healthcare workers with infected patients. This paper briefly describes the working of the IoT enabled healthcare device and the methodology used in detail. The cost of the proposed device is very less compared to other existing systems.


The standard practice employed by dermatologists for examining skin lesions is dermoscopy, where an epiluminesence microscope (ELM) is used to examine the skin chrominance and micro-structural characteristics for anomalies. Conventional ELM instruments are being replaced by digital ELM instruments that enable der- matologists and other health care practitioners to digitally capture, archive, and analyze skin lesions using computer-aided diagnosis (CAD) software. One of the limiting factors of digital ELM is the fundamental trade- off between spatial resolution and field-of-view (FOV), where a larger FOV (which is needed to allow for larger skin lesions to be examined in their entirety) can be achieved by reducing magnification at the cost of spatial resolution (leading to a loss of fine details that can be indicative of malignancy and disease). Here, we introduce deep computational optics (DCO) for the purpose of resolution-enhanced digital ELM to improve the balance between spatial resolution and FOV. More specifically, the multitude of parameters of a deep computational model for numerically magnifying digital ELM images are learned through a wealth of low-resolution and high- resolution digital ELM image pairs. The proposed DCO approach was experimentally validated, demonstrating improvements in the spatial resolution of the resolution-enhanced digital ELM by two-fold while maintaining FOV.


This paper reports intensity-time signatures of eight impulsive (nearly) pure solar electron (Ee≳45 keV) events observed in interplanetary space in the heliocentric radial range 0.7<r<1.0 AU, seven by Mariner V (July–October 1967) and one by Mariner II (November 1962). In six cases, simultaneous solar X ray and Earth-based optical data provide reasonably certain identification of the causative flares. Complementary data on X ray emission and electron angular distributions from Explorer 33 (in a loose Earth orbit) and Explorer 35 (in a lunar orbit) are also cited. In all eight cases the electron signatures exhibit a two-phase structure, an early scatter-free peak [Lin, 1970] having a duration of ≲20 min and a subsequent main phase having a full width at half maximum of several hours. A detailed analysis of each intensity-time signature is described, and the corresponding parameters are tabulated. All main phases are well represented by a three-dimensional, isotropic diffusion equation, although it is puzzling that such a representation can be so empirically successful. The principal results are apparent values of the interplanetary diffusion coefficient D and corresponding values of the mean free path λ between scattering centers for the main phases. Values of λ range from 0.035 to 0.154 AU. The mean of these values is 0.091 (±0.013) AU and the standard deviation of individual values from the mean is 0.040 AU. This standard deviation exceeds the estimated uncertainty of each determination by a factor of about three and is plausibly attributed to variability of the properties of the interplanetary magnetic field.


This paper deals with the creation of modern high-performance aircraft power units based on the Wankel rotary piston engine. One of the main problems of Wankel engines is high specific fuel consumption. This paper solves the problem of improving the efficiency of this type of engine. The mathematical model of non-stationary processes of transfer of momentum, energy, mass, and the concentration of reacting substances in the estimated volume provides for the determination of local gas parameters in the entire computational region, which are presented as a sum of averaged and pulsation components. The k-ζ-f model is used as the turbulence model; the combustion is described by the coherent flame model (CFM) based on the concept of laminar flame propagation. As a result of the calculation, we obtained the values of temperature, pressure, and velocity of the working fluid in the working chamber cross-sections of a rotary–piston engine. Various options of the rotor recess shape are considered. Based on the data obtained, the rotor design was improved. The offered shape of the rotor recess has reduced emissions of both nitrogen oxides and carbon dioxide.


The purpose of this research was to explore how participants perceived themselves as preservice music teachers. Bouij's (1998) salient role-identities in music education served as an a priori theoretical framework. By investigating participants' perceptions of role-identity, some of the socialization processes that contributed to identity development were also revealed. Multiple forms of data were collected including interviews, both individual and focus group, and field notes from peer teaching sessions. Analysis resulted in three themes: (a) Role-Identities, (b) Peers, and (c) Authentic Teaching Experiences. Participants believed they embodied a primary and secondary role-identity and perceived subtle expansions of their role-identities as they progressed through their undergraduate degree program. Participants discussed the importance of their peers and authentic teaching experiences in their development as music teachers. Suggestions for practice and further research are provided.


Abstract The paper analyses some aspects of healthy and diseased bodies presented in Nadine Gordimer's latest writings that mark the writer's return to senses. Some of Susan Sontag's considerations on'illness and its metaphors' are introduced in order to accentuate the significance of the healing proces in the circle of health, disease and recovery.


Objective: To observe clinical effect of the treatment of ulcerative colitis with Traditional Chinese Medicine and ulcers scattered enema.Methods: 120patients were randomly divided into treatment group of 60cases and control group of 60cases,which were treated respectively by means of selecting different prescriptions of Traditional Chinese Medicine and ulcers scattered enema in treatment group,and Sulfasalazine(SASP) preparation and Hydrocortisone sodium succinate enema were used in control group.Results: The total effective rate was 95.0% in the treatment group and 83.3% in the control group.Conclusion: Selecting different prescriptions of Traditional Chinese Medicine and ulcers scattered enema for ulcerative colitis has a better curative effect.


Dexterous anthropomorphic robotic hand has very important applications in service robot for cooperating with people in the daily living environment and using the tools specifically designed for people. In this paper, we designed a dexterous anthropomorphic robotic hand mimicking the muscle-tendon-ligament structure of the human hand. The robotic hand possesses the similar Degrees of Freedom (DOF) configuration of the human hand. Each DOF is driven with a pair of antagonistic pneumatic artificial muscles, and Bowden wires are carefully laid for mimicking the tendons of the human hand to facilitate the motion control of the robotic hand. Rubber bladders with force sensors are also employed as the skin of the palm and the finger pad to enable the force control and compliant manipulation of the robotic hand. As a result, the robotic hand can reproduce the manipulations of the human hand, and thus can be deployed on a robot to cooperate with people or on a homogeneous slave robot to improve its tele-operation performance.


pathogenic microflora of the skin is provided. It is shown that the microbial flora of the skin causes complications of an underlying disease in a significant proportion of patients with allergodermatoses. The control mechanisms of the integrity of the body's barriers in mammals are presented. In particular, the role of the epidermal barrier impairment on the association of atopic dermatitis and infection is discussed. The main directions in the treatment of allergodermatoses are described based on Russian and International Clinical Guidelines for the treatment of atopic dermatisis. The significance of topical antibacterial and combined drugs in the treatment of complicated allergodermatoses is defined.


A new project-based service learning program was created at Michigan Tech during the Spring 2005 semester. The program uses the same structure as Michigan Tech's enterprise program which gives students the opportunity to work on multi-disciplinary, student-led teams solving industry-supplied engineering projects. The service and leadership enterprise (SLE) shifts the focus from an entrepreneurial enterprise to that of a non-profit organization solving humanitarian problems. Although each of Michigan Tech's Enterprise teams is intended to be multi-disciplinary, most attract one primary engineering discipline. This new enterprise has attracted students from the sciences and business, as well as multiple engineering disciplines and will provide a very diverse setting for engineering design. During the first semester the students defined their own vision for the enterprise and visited the community they would be working with in their inaugural project. SLE's initial project will be partnering with a church on the Oglala Sioux reservation to build a community center


In this article,the author introduces the historical background of compilation of "Technical Code for Roof Engineering",clarifies principles of compilation of this new standard,and states main contents of the new standard.


Introduction: High-density lipoprotein particle concentration (HDL-P) and size (HDL-Sz) impact atherogenesis and inflammation, both of which are implicated in the pathobiology of heart failure with...


The Scottish government has said that it will not impose a new contract on junior doctors in Scotland. Scotland's health secretary, Shona Robison, said that the government would instead maintain the current "new deal" contract for junior doctors.

The news came after the UK BMA's Junior Doctors Committee announced that it would not re-enter negotiations with NHS Employers over a new contract for trainees.1 In a report published on 16 July the Review Body on Doctors' and Dentists' Remuneration (DDRB) made recommendations …


Aims: Our aim was to study the relationship between markers of cell proneness to apoptosis and indices of insulin resistance and dyslipidemia in children born with low birth weight (LBW). Methods: The study comprised 177 prepubertal children stratified by birth weight and their nutritional status into LBW (n = 138) and normal birth weight (NBW; n = 39) groups. We analyzed DNA from peripheral blood lymphocytes, separated by pulsed-field gel electrophoresis (PFGE), as well as the serum levels of cholesterol, HDL-cholesterol, triglycerides, fasting insulin and glucose, caspase 3, and BCL2. Results: LBW children with a BMI SDS >1.55 demonstrated increased content of the large fragments of the lymphocyte DNA [300-500 kb (DNA300-500 kb)] in electrophoretic slides (a marker of decreased chromatin stability and susceptibility of cells to apoptosis) compared to the NBW group. In these children the level of DNA300-500 kb exhibited a strong negative correlation with the serum level of antiapoptotic protein of BCL2 (r = -0.901). DNA300-500 kb significantly correlated with calculated indices of insulin resistance: HOMA-IR and QUICKI as well as with the indices of lipid homeostasis (Castelli and AIP). Conclusions: Increased susceptibility of lymphocytes to apoptosis correlated with a higher risk of insulin resistance and lipid disturbance in overweight or obese LBW children. A comprehensive study of the proneness of cells to apoptosis should be implemented to further investigate the pathomechanism of the metabolic syndrome in these children.


In recent years, facility management (FM) has adopted many computer technology solutions for building maintenance, such as building information modelling (BIM) and computerized maintenance management systems (CMMS). However, maintenance requests management in buildings remains a manual and a time-consuming process that depends on human management. In this paper, a machine-learning algorithm based on natural language processing (NLP) is proposed to classify maintenance requests. This algorithm aims to assist the FM teams in managing day-to-day maintenance activities. A healthcare facility is addressed as a case study in this work. Ten-year maintenance records from the facility contributed to the design and development of the algorithm. Multiple NLP methods were used in this study, and the results reveal that the NLP model can classify work requests with an average accuracy of 78%. Furthermore, NLP methods have proven to be effective for managing unstructured text data.


The invention concerns a continuous reaction method by solid/gas catalysis in unconventional medium, using different substrates to obtain predetermined products, substrates and products forming compounds, which consists in controlling: the reaction in temperature to determine the saturation pressure of each pure compound taking part in determining the compound thermodynamic activity; the total pressure at a level lower than atmospheric pressure; the molar flow rates of the compounds and the vector gas, to adjust the gas mixture molar composition on the basis of the predetermined values of the thermodynamic activity of said compounds.


prompted us to examine in detail the sources and magnitude of its inaccuracies in measuring binding constants, especially those of cyclodextrin (CD) complexation. Such a study will surely benefit the future research, though surprisingly it has not been conducted before. Experimental The basic approach of the present study was computer simulation. The computer program, written in Borland C++ 5.0, was run on a PII400 computer. CD complexation was investigated as a typical system, for CD was one of the most frequently encountered host molecules in the field of molecular recognition. In the simulation, the real concentration of the substrate was chosen as 1.00× 10 ‐4 M for all the solutions. The real binding constant (K) was chosen as 50, 1000 or 10000 M ‐1 . The molar absorption constant of the free substrate ( e0) was taken as 5000 m 2 /mol, while the molar absorption constant of the bound substrate (e∞ ) was chosen as 4950, 4850, or 4750 m 2 /mol, respectively. Seven different real CD concentrations were used: 0.0000, 0.0025, 0.0040, 0.0055, 0.0070, 0.0085 and 0.010 M. Herein, the absorption of CD was presumably zero. Three replicate solutions were prepared at every CD concentration, and their absorption values were averaged to offer the absorption value at the given CD concentration. It was noteworthy that the present selections of host and guest concentrations for simulation were reasonable, for they were based on the practice in real experiments.


On the basis of the theories of consumer demand and consumptoion behavior,the thesis studied influencing factors of brand eggs' consumption amount in Beijing by the means of statistic analysis and quantitative analysis on current consumption situation of brand eggs.The study got the result that the consumption amount of brand eggs was influenced by its price,income,age,geographical factor and so on.


As China successfully entered the WTO, Beijing successfully bid for the Olympic Games, and Shanghai successfully bid for the EXPO, more and more highly-qualified talents in the field of foreign languages are demanded by the society. Certain achievements have been made in the field of CET, but these achievements do not yet satisfy with the reality of the economic developments and reforms in China. To meet the needs of the new situation, the reform in the CET must be enforced.


Detailed three dimensional calculations are made to study the generation of secondary flows in conducting and insulating sidewall diagonal channels. The secondary flows have considerable influence on the velocity overshoots, momentum and thermal mixing, flow asymmetry, and the power output. They tend to diminish the velocity overshoots, to promote mixing, and to introduce flow asymmetry. The gross predictions of the three dimensional model are compared with the experimental data and found to be in good agreement.


It can't defend on only KS for appraisal tests on specific performance items. So, it needs to grasp the correspondence on various international standards. Generally, absorbing performance for injury prevention when human body collided knows that it different following a criterion of evaluation standard or performance values. It is difficult to mention test method of same subject because of different test purposes and test requirements. The purpose of this study was to prove correlation of several test methods on same test items by comparing and analyzing absorbing performance measurement results.


Objective To explore influential factors contributing to the choice of primary care facilities (PCFs) for the initial treatment among rural and urban residents in Southwestern China. Methods A face-to-face survey was conducted on a multistage stratified random sample of 456 rural and 459 urban residents in Sichuan Province from January to August in 2014. A structured questionnaire was used to collect data on residents' characteristics, provider of initial treatment and principal reason for the choice. Multivariate logistic regression was performed to identify factors associated with choosing PCFs for the initial treatment. Results The result showed that 65.4% of the rural residents and 50.5% of the urban residents chose PCFs as their initial contact for medical care. Among both rural and urban residents, the principal reason for choosing medical institutions for the initial treatment was convenience (42.3% versus 40.5%, respectively), followed by high quality of medical care (26.5% versus 29.4%, respectively). Compared to rural residents, urban residents were more likely to value trust in doctors and high quality of medical care but were less likely to value the insurance designation status of the facilities. Logistic regression analysis showed that both rural and urban residents were less likely to choose PCFs for the initial treatment if they lived more than 15 minutes (by walk) from the nearest facilities (rural: OR = 0.15, 95%CI = 0.09–0.26; urban: OR = 0.19, 95%CI = 0.10–0.36), had fair (rural: OR = 0.49, 95%CI = 0.26–0.92; urban: OR = 0.31, 95%CI = 0.15–0.64) or poor (rural: OR = 0.14, 95%CI = 0.07–0.30; urban: OR = 0.22, 95%CI = 0.11–0.44) self-reported health status. Among rural residents, attending college or higher education (OR = 0.21, 95%CI = 0.08–0.59), being retired (OR = 0.90, 95%CI = 0.44–1.84) and earning a per capita annual income of household of 10,000–29,999 (OR = 0.24, 95%CI = 0.11–0.52) and 30,000–49,999 (OR = 0.26, 95%CI = 0.07–0.92) were associated with lower rates of seeking care at PCFs. Conclusion Efforts should be made to improve the accessibility of PCFs and to upgrade the services capability of PCFs both in rural and urban areas in China. At the same time, resources should be prioritized to residents with poorer self-reported health status, and rural residents who retire or have better education and higher income levels should be taken into account.


London 2012 has developed a carbon footprint methodology which will provide for a benchmark in measuring the full project carbon footprint of a major event. This methodology follows the Greenhouse Gas Protocol (GHG Protocol) and expands on the existing transport emission approach. Transport arrangements were identified as 17 per cent of the overall London 2012 carbon footprint. Sustainable low carbon transport has been a fundamental principle in Games transport planning. This paper reviews the Olympic Delivery Authority's (ODA's) approach to reducing the carbon impact of its transport arrangements and associated lessons learned. One of the key learning's has been that carbon impact of transport arrangements must be a priority consideration when planning for a truly sustainable event. Transport was fundamental in selecting the location for the Olympic Park near major transport interchange, and in locating many venues together to minimise the need for inter-venue transport. The carbon footprint approach/methodology considered not only the transport emissions using the Department for Environment, Food and Rural Affairs (Defra) emissions factors, but considered also the spare capacity within existing scheduled public transport services. It is this use of existing capacity that can achieve the greatest wins in low carbon transport for events. Events should be planned to timescales to coincide wherever possible to utilise the existing capacity, considering additional services only where necessary.


Thomson scattering measurements of the electron temperature in laser-produced gold plasmas are presented. We irradiated a flat gold disk target with one laser beam of the Nova laser facility at an angle of 64° from the normal. A second laser beam probed the plasma at a distance of 500 μm with temporally resolved Thomson scattering. The electron temperature measurements are compared with hydrodynamic simulations using the code LASNEX for experiments applying smoothed and unsmoothed heater beams. In case of an unsmoothed heater beam the simulations predict temperatures which are about 40% higher than our measured data. Although the agreement is improved for a smoothed heater beam, discrepancies exist in the decay phase of the plasma. We discuss possible explanations for these observations.


In order to understand the temporal variation of the atmospheric suspended particulates in Beijing,the observational data of the Total Suspended Particulates(TSP) and inhalation particle matter(PM10) during the whole year of 2000 was analyzed.The result showed that the suspended particulates concentration exhibited a distinct seasonal variation: the highest in spring and the lowest in summer.There was a good linear relationship between the concentration of TSP and PM10(correlation coefficient was 0.77).Back trajectory analysis indicated that the source region of sandstorm on 6 and 25 April,2000 probably originated from the southeastern part of Mongolia and the Midwest of Inner Mongol.


A new rocket test stand facility, built at the University of Alabama at Huntsville, equipped with palletized propellant feed systems, 1000 lbsf thrust stand, and data acquisition systems, was constructed to test a nitrous oxide/propane (NOP) rocket engine. A unique rocket ignition concept using catalytically decomposed nitrous oxide was explored and various catalyst materials were evaluated. Shell-405 and cobalt based ZSM-5 showed promising reactivity, demonstrating sufficient decomposition of N2O to ignite hydrocarbon fuels, e.g. propane. Laboratory experiments with the catalyst reactor showed that N2O catalytic decomposition is achievable at 400 °F for pure nitrous oxide flowing over Shell 405, and, with the use of trace amounts of a hydrocarbon (e.g. propane or propylene), this temperature was lowered to approximately 200 °F. The NOP rocket was tested over a range of mixture ratios (4.89<M.R.<8.68), for an L*=3m. Experimental results match well with theoretical predictions, with proper modeling of heat losses. The operational envelope for stable NOP rocket combustion was identified to be for N2O flow rates < 0.270 Ibn/sec and mixture ratios between 5-6. Radiometric measurements were also used to determine rocket exhaust temperature and plume composition and plume pitot probe measurements provided another method for verifying thrust data.


To the Editor: Chronic neutrophilic leukaemia (CNL) is a very rare myeloproliferative disorder characterized by a remarkable increase in mature neutrophils without an underlying cause such as infection or neoplasm (1). An elevated leukocyte alkaline phosphatase (LAP) score and absence of the Philadelphia (Ph) chromosome are two important features that distinguish CNL from chronic myelogenous leukaemia (CML). CNL presents with a gradually progressive clinical course. Persistent neutrophilia may be due to the prolonged survival of peripheral neutrophils. In order to clarify this hypothesis, we investigated spontaneous apoptosis in the neutrophils of a CNL patient. A 56-yr-old male was referred to our hospital because of leukocytosis and marked hepatosplenomegaly. Peripheral blood showed an 8.5 g/dl haemoglobin level, a white blood cell count of 40.8r10/l, including 90% mature neutrophils, and a platelet count of 33.7r10/l. A bone marrow examination revealed myeloid hyperplasia with no dysplastic features. A cytogenetic study of the bone marrow cells revealed 46XY without the Ph chromosome. Furthermore the mRNAs encoding P190, P210 and P230 were not detected. The circulating granulocyte colony-forming unit (CFU-G) increased to 298t15.0/lr10 cells, and to 39.0t15.0/lr10 cells in the absence of granulocyte macrophage colony-stimulating factor (GM-CSF). These circulating progenitor cells and spontaneous colony formation are commonly observed in cases of myeloproliferative disorder (2). Peripheral blood neutrophils were obtained using dextran sulfate and Ficoll-Hypaque from the patient and three healthy volunteers who acted as controls. Informed consent was obtained from all subjects prior to their participation in this study.


The compensatory prophylaxis hypothesis (CPH) proposes that evolved psychological mechanisms enhance the avoidance of potential contaminants during periods of reproductive immunomodulation in order to decrease a chance of infection. However, the results of previous studies are inconclusive. Our aim was to investigate the differences in disgust sensitivity during phases of menstrual cycle in regularly cycling young healthy women and among women who reported having an infection.


In Arthritis, the self-limiting inflammatory process becomes continuous and as a result chronic inflammatory disease might occur. The skin surface is responsible for maintaining the core internal body temperature. Medical Infrared thermography (MIT) as a diagnostic tool is well known for its contribution in providing statistical quantification to detect acute to minute temperature deviation for accurate assessment of inflammation. Accurate assessment of inflammation helps in making early individual treatment plan and also offers an insight to the determination of severity of the disease. In this scope, we validate the importance of infrared imaging with a newly created datasets of Arthritis knee joints. After validation, the efficacy of infrared imaging is also proved as a complementary diagnostic tool to other clinical tests in detecting inflammation that lacks recognizable clinical findings in relation to Arthritis.


Based on the analysis of the main problems involved in the programming of computer operating exam system of Sichuan computer graded examination.Some solution is provided in this paper.


Eleven patients (two male, nine female) were treated with epidural sympathetic blockade for reflex sympa thetic imbalance, an incomplete manifestation of reflex sympathetic dystrophy. Each had developed severe pain, sensitivity, and disability disproportionate to as sociated trauma. One patient injured an ankle, and the remaining 10 patients one or both knees (12 knees). Seven patients had undergone previous surgery. All but one had a favorable response to initial blockade. This individual eventually failed treatment despite surgical sympathectomy. Seven have required readministration of a block for clinical relapse. Mean followup was 22 months (range, 10 to 41 months). Five underwent ex tensive psychological testing. All have required adjunc tive forms of therapy including physical therapy, trans cutaneous electrical nerve stimulation (TENS), antiin flammatory or other nonnarcotic agents. Recovery is typically prolonged, particularly if the diagnosis is de layed. Close attention to, and therefore prevention of, situations that trigger its recurrence is essential for successful rehabilitation.


360 Video has become popular in recent years, as commercial interests in deploying Virtual Reality (VR) applications rise. This type of video is usually captured using multi-camera arrays, such as the GoPro Omni camera rig. After separate video streams are captured from multiple cameras, image stitching is applied to obtain a spherical representation of the scene, which spans 360 degrees horizontally and 180 degrees vertically, hence the name 360 video. In the existing workflow of 360 spherical video coding, the 360 video is projected onto the 2D plane with a projection format, such as equirectangular (ERP), cubemap (CMP), equal-area (EAP), octahedron (OHP), etc. Most, if not all, of the currently available 360 video content are provided in ERP format defined in longitude and latitude. Projection format conversion may be performed to convert the native ERP format to another format before coding is applied. Some projection formats contain more than one face, for example, CMP projects the sphere onto a cube of six faces or OHP projects the sphere onto an octahedron of eight faces. For these multi-face projection formats, the faces are packed onto a 2D rectangular picture with a frame packing method. For example, the six faces of CMP can be packed with 4x3 configuration, or 3x2 configuration. Finally, the frame packed picture is coded as a 2D conventional video. Existing video codecs are designed only considering conventional 2D video captured on a plane. When motion compensated prediction uses any samples outside of a reference picture's boundaries, padding will be performed by simply copying the sample values from the picture boundaries. This repetitive padding method is referred as conventional 2D padding method, which is widely used in video coding standards such as H.264, High Efficiency Video Coding (HEVC). However, a 360 video encompasses video information on the whole sphere, and thus intrinsically has a cyclic property. When considering this cyclic property, the reference pictures of a 360 video no longer have "boundaries", as the information they contain is all wrapped around a sphere. This cyclic property holds regardless of which projection format or which frame packing is used to represent the 360 video on a 2D plane. The paper presents a new geometry padding method for motion compensated prediction in 360 video coding. Unlike the conventional padding method for 2D video coding, the proposed geometry padding method extends samples outside of a 2D picture's boundaries using neighboring samples on the sphere. The geometry projection format is considered when performing padding. The corresponding sample outside of a face's boundary (which may come from another side in the same face or from another face), is derived with rectilinear projection. Each face is extended with geometry padding separately. When visualized, the extended faces using geometry padding show continuous texture representing natural extension of the texture inside the face. The proposed geometry padding method is implemented in the HEVC reference software HM-16.12 for the ERP and CMP projection formats. In the simulation, a total of sixteen 4K ERP video and eight 8K ERP video are used. For 8K ground truth 8K video, they are converted to 4K video in ERP and CMP projection formats, coded, and converted back to reconstructed 8K video in ERP format. For 4K ground truth video, they are directly coded in 4K ERP, or converted to CMP consisting of 75% of effective samples, coded, and converted back to reconstructed 4K video in ERP format. Then, the end-to-end spherical PSNR (S-PSNR) is calculated between the original 8K or 4K and the reconstructed 8K or 4K ERP video. BD-rate is calculated between the reference unmodified HEVC, which uses the conventional padding method, and HEVC modified with the proposed geometry padding method. Simulation results showed that geometry padding performs better. For 8K sequences, the proposed geometry padding gives on average luma (Y) BD-rate reduction of 0.3% for ERP and 0.8% for CMP, for 4K sequences, the proposed geometry padding gives on average Y BD-rate reduction of 0.2% for ERP and 1.0% for CMP. Comparing the gains in ERP format with the gains in CMP format, the improvement for CMP is larger. This is because CMP has six faces, therefore the improvement from geometry padding method affects more out-of-boundary samples. The proposed geometry padding method is also especially effective for sequences with fast motion. For example, it achieves BD rate reductions of 4.3%, 2.7%, 1.9%, and 2.5% for Glacier, Chairlift, Sb_in_lot, and Driving, respectively. These four sequences are all captured using moving cameras and have fast moving objects. As a result, the sequences contain a lot of across-the-face-boundary motion which can benefit from improved padding method. Detailed simulation results can be found in JVET contribution JVET-D0075 available at http://phenix.int-evry.fr/jvet/doc_end_user/documents/4_Chengdu/wg11/JVET-D0075-v3.zip.


The influence of the supporting electrolyte on the height and frequency dependence of tensammetric waves is examined. Anions generally affect the positive tensammetric waves whereas cations have little effect on either positive or negative waves. A tentative explanation of the underlying phenomena is given and the possible mechanism discussed.


The article considers sports in the context of its humanistic values. The undertaken research deals with problems and prospects of the sports development, and proves that the sports values reflect moral and material, personal and social aspects. The sports are examined as a basis for individual fulfillment and a way of personality self-development. The author discusses problems of popular and Olympic sports, and substantiates the sports as a major unifying force promoting integration and enhancement of the humanity.


The present invention relates to laminate products comprising a non-wood cellulosic panel with at least one nonwoven fabric mat adhered thereto as well as to methods of making such laminate products.


Thereis a constant increase of temperature on global scale from north to south. An increase of 0.9 degrees Celsius is monitored since 1906 onward. In addition, this increase of temperature is even more at some particular polar areas both in north of 60°N and south of 60°S. Both Arctic and Antarctic regions require oceanographic observations more than ever now. It is pertinent to mention here that during the past decade, though the temperatures in Antarctic have remained consistent but the Arctic has experienced an increase of 0.75 °C which appears to be much higher than even the global average. Similarly, the Arctic is going through vanishing ice sheets, a gradual rise of traffic in this particular part of the ocean, and, last but not least, a drastic increase in exploration of natural resources. Furthermore, the ice covering protection of Antarctic requires continuous monitoring & persistent measurement. In this regard, polar Argo buoys have initiated collecting data at poles due to technological improvements in buoys. These improvements include the both way communication with the aid of Iridium satellite network, upgraded software to store winter profiles and algorithm development for avoidance of ice. It is recommended to increase Argo standard sampling (3° × 3°) towards poles by enhancing 285 buoys in the sea of Arctic and 360 in the proximity of Antarctic. It is pertinent to mention here that despite the aforementioned improvements, the Argo buoys still experience varying damages caused to their expensive gear on multiple occasions thus limiting their frequent employments. In addition to that, the survivability of Argo floats is compromised in polar regions as compared to the open global oceans. The accumulative effects of such causes make the cost of even a single Conductivity-Temperature-Depth (from now on CTD) profile to be much costly with regard to the profile obtained from open oceans. Similarly, in order to develop gridded fields of salinity & temperature which optimally preserve the temporal and spatial capacities of the profiling buoys for the Argo array, the In-Situ Analysis System (ISAS) was evolved. In 2009, re-analysis on global scale was conducted for the first time. Since then, this particular system has been upgraded to include all kinds of time series along with the profiles of vertical. These gridded spheres of ISAS are utterly comprising in-situ outcomes. This near real-time temperature- salinity gridded data on the global scale is acquired for the upper 2000 meters. An optimum interpolation is the basis of these gridded Argo data sets. These data sets are considered as a source of observation in the bipolar regions of the globe. Finally, animals are equipped with Autonomous CTD-Satellite Relay Data Loggers (from now on CTD-SRDLs) which are mounted on such animals on land. Then, the data is acquired & stored in the form of hydrographic profiles during their foraging travels. The moment these seals return to surface, the data is transmitted by satellite ARGOS. The ARGOS satellites are responsible to ascertain the position of the seals by employing triangulation. On the Southern fronts of the ocean, data is processed and saved by the Sea Mammal Research Unit (SMRU). This data is then received by the Global Telecommunication System (GTS) in real-time. This particular CTD data undergoes a post-processing proceeding which involve editing, rectification, & subsequent endorsement of hydrographic measurements. These records are then made public via varying portals. In general, such CTD-borne animals are relentlessly recording and offering vertical temperature-salinity profiles up to the depth of 2000 meters. This particular study is aimed at analyzing multifarious ways to obtain better estimation of both thermal & salinity measurements in and around the surroundings of polar regions. To accomplish this, the study discusses viable data in the proximity of bipolar regions from Argo, gridded Argo data sets, and CTD-borne animals in order to highlight the prospect of covering polar oceans. Consequently, the data from the 03 sources is presented both on individual and comparative charts at 02 core locations in the proximity of the polar regions.


The anti-oxidation activity of orange tegument extractives was studied, as well as their effectual ingredient. The results showed that better extraction is microwave, the best extraction conditions: using 80% alcohol as solvent , ratio of solid to liquid as 1∶10 , microwave firepower 40%, disposal time 50 s; Using the UV absorption spectrum and the colour experiment to perform qualitative analysis, the extractives mostly contain dihyo-flavonoid.


The NEMO oceanic model is widely used among the climate community. It is used with different configurations in more than 50 research projects for both long and short-term simulations. Computational requirements of the model and its implementation limit the exploitation of the emerging computational infrastructure at peta and exascale. A deep revision and analysis of the model and its implementation were needed. The paper describes the performance evaluation of the model (v3.2), based on MPI parallelization, on the MareNostrum platform at the Barcelona Supercomputing Centre. The analysis highlighted different bottlenecks due to the communication overhead. The code has been optimized reducing the communication weight within some frequently called functions and the parallelization has been improved introducing a second level of parallelism based on the OpenMP shared memory paradigm.


Surveillance and security, autonomous driving, robotics, and medical imaging are just some of the fields that might benefit from computer vision tasks like monitoring and identifying moving objects in video frames. Several methods have been proposed over time as possible answers to the challenges of monitoring and identifying moving objects. Occlusion, lighting changes, blurring in motion, and distracting backgrounds are all examples of these challenges. Algorithms have improved in accuracy, robustness, and efficiency thanks to recent breakthroughs in fields including deep learning, multi-modal data fusion, attention mechanisms, online learning, unsupervised learning, motion segmentation, graph-based techniques, and reinforcement learning. Tracking and identifying moving targets has many potential uses across many fields, and it will only grow in significance as technology develops. However, there are still problems that need to be fixed, including real-time processing limitations, occlusion, motion blur, sensitivity to lighting changes, and scene complexity management. These are only a few examples of the problems that still require fixing. This research provides an overview of the challenges, current solutions, practical applications, and potential future developments associated with identifying and tracking moving objects in video. Future research opportunities are also highlighted in this overview.


This paper itemises and examines some of the myths that appear to be building up in geography around the topic of behavioral research. In particular it traces some of the reasons for the development of behavioral approaches in the discipline, defines some of their fundamental characteristics, and examines the epistemological bases of selected types of behavioral research. Comments are made about research on utility and choice, mobility and migration, and cognitive mapping in an attempt to dispell these myths—or at least to inhibit their further development and acceptance.


Prostate cancer (PCa) is a prevalent and deadly cancer worldwide. Considering the malignant progression and therapeutic resistance of PCa, further dissection of the underlying mechanisms and exploration of novel therapeutic targets for PCa are urgently needed. The long noncoding RNA HOTTIP has recently been revealed as an oncogenic regulator in different cancers; however, whether HOTTIP is involved in PCa remains poorly understood. Here, we examined the crucial roles of HOTTIP in the proliferation and chemoresistance of PCa.


Ridgewood School in north Doncaster is one of the UK's leading specialist schools in engineering and related technologies. The school has recently been awarded a second specialism in applied learning, and welcomes over 1,400 pupils through its doors every day. The author describes how the IET's Faraday Web site, with a shot of inspiration from the BBC's 'Dragon's Den', formed the basis of a highly successful STEM enrichment day.


Severe peritonitis causing death and/or technique termination (catheter explanted) is one of the most devastating complications of peritoneal dialysis (PD). The aim of this case series study was to reveal the predictors of risk and clinical characteristics of these cases. We included 38 patients with either peritonitis causing death (18 patients, 47%) or catheter removal (20 patients, 53%) in the period 1996–2006. Their last clinical, laboratory and peritoneal equilibration test data before the peritonitis episode and hospitalization data after the start of peritonitis were reviewed. Their median (range) age was 66 (25–85) years, 61% were male, and the median PD duration was 60 (1–144) months. Baseline C‐reactive protein (17.5 ± 19.1 mg/L) was substantially higher than in contemporary stable controls from our unit (3.5 ± 4.2 mg/L, P = 0.002). For 14 patients (37%), this was their first episode, with a significantly lower mortality of 14% as opposed to 47% across the whole group (P = 0.002). Almost half the patients (42%) had a causative abdominal condition identified, such as diverticulitis or cholecystitis. Clinical and laboratory data at presentation were variable and not different according to survival. Non‐surviving cases had a significantly larger proportion of fast transporters (83 vs. 45%, P = 0.03), a significantly lower estimate of daily protein intake (0.72 vs. 0.88 g/kg/day, P = 0.007), and a significantly higher proportion of non‐Gram‐positive causative microorganisms (72 vs. 40%, P = 0.019). The patients with severe peritonitis were characterized as older with a longer PD duration, and a higher baseline C‐reactive protein. Fast peritoneal transport, lower normalized protein catabolic rate, and non‐Gram‐positive causative bacteria were associated with mortality.


e14503 Background: Adenoviral-based oncolytic virus (OV) therapeutics include mutations that enable activity in tumor cells and limit toxicity in normal cells. These tumor selectivity approaches often involve mutating viral E1A function or expression; however, such modifications allow viral activity in normal cells or limit anti-tumor potency. ICVB-1042 was engineered with dual modifications in E1A and E4orf6/7, resulting in superior tumor selectivity that does not compromise lytic potency in tumor cells. This improved tumor selective virus minimizes off-tumor activity and promotes robust tumor lysis. Methods: ICVB-1042 was compared to viruses with wildtype E1A and E4orf6/7 and a clinically tested virus with an E1A mutation (ICVB-2006). Viral function and killing were assessed in primary normal human renal (HRE) and bronchial (BrE) epithelial cells in the presence of the inhibitor palbociclib to pharmacologically block S-phase entry via host cell signaling. HRE and BrE were infected with virus and evaluated for indicators of viral toxicity in normal cells. Viral replication was quantified by droplet digital polymerase chain reaction (ddPCR); cell lysis was quantified by WST-1 assay. An S-phase induction assay was developed using an mCherry-Geminin reporter that allows imaging-based quantification of viral-dependent entry to S-phase. Viral activity in cells was compared with and without the CDK4/6 inhibitor using a viral-encoded fluorescent reporter to determine the requirement for host cell proliferation on viral function. Results: ICVB-1042 demonstrated superior protection in normal cells to comparator ICVB-2006 and viruses lacking tumor selectivity modifications. Palbociclib steeply reduced viral reporter gene expression (63-88% reduction), viral replication ( > 10-fold reduction), and cytolytic activity of ICVB-1042, while non-selective viruses were unaffected by this treatment. Non-selective virus infection resulted in 3.3- to 6.1-fold higher levels of S-phase entry compared to ICVB-1042. ICVB-2006 infection resembled non-selective viruses at the level of S-phase induction (3.1- to 3.3-fold above ICVB-1042) and viral reporter gene expression was modestly inhibited by palbociclib (12-31% reduction). Conclusions: The improved tumor selectivity of ICVB-1042 results in protection of normal, non-proliferative cells from viral-mediated toxicity. The conventional approach of ICVB-2006 with a single E1A mutation leaves viral replication and cell death in normal human cells mostly intact. Together, these observations support that ICVB-1042 presents normal cell protection and reduced toxicity risks associated with OV therapy.


The differential equations representing the coupled heat transfer from the solid nuclear core components to the helium in the coolant channels are scaled in terms of representative quantities. This scaling process identifies the relative importance of the various terms of the coupled differential equations. The relative importance of these terms is then used to simplify the numerical solution of the coupled heat transfer for two bounding cases of full-power operation and depressurization from full-system operating pressure for the Fort St. Vrain High-Temperature Gas-Cooled Reactor. This analysis rigorously justifies the simplified system of equations used in the nuclear safety analysis effort at Oak Ridge National Laboratory.


Electric field enhancement of photoemission from negative‐electron‐affinity surfaces on silicon and GaAs has been studied. It is shown that the electric field increases the escape probability and does not change the spectral response of negative‐electron‐affinity surfaces. The results are explained by assuming a simple surface potential barrier together with work function lowering by the Schottky effect.


Why is the law that has the purpose to regulate social order, would lead to chaos in the community? There are two things that need to be observed, first, because the law narrowly conceived, which in turn tend to be formalistic, involutive, slow and lack of the capacity to adapt and anticipate the development of complex aspects of community life and progressive. This is the failure of positive law that could not see far ahead. Second, the attitude of law enforcement officials often ignore the public sense of justice with controversial and discriminative decisions. The implication of this phenomenon is the number of resistance legal product in the community. Laws experiencing poverty of Indonesian ideology substantively have lost the "spirit", which should be entailed by the law itself has gained fresh air when present progressive legal thought  presents in the middle of dialectical thinking in Indonesia law.


We have demonstrated that pretreatment with a lignan‐enriched extract of Fructus schisandrae (FS) protected against physical exercise‐induced muscle damage in rats. The muscle protection afforded by FS pretreatment was associated with a significant enhancement in hepatic antioxidant status, as assessed by hepatic glutathione (GSH) and malondialdehyde (MDA) levels. Pretreating rats with α‐tocopherol acetate, though decreasing the MDA level in skeletal muscle, did not protect against exercise‐induced muscle damage or improve hepatic antioxidant status in exercised rats. The results indicate that the protective effect of FS pretreatment on physical exercise‐induced muscle damage may result from the enhancement of hepatic GSH status, thereby providing sufficient GSH for effective antioxidant protection of skeletal muscle during exercise.


Abstract Behaviour disorders represent a major concern in today's schools. One widely used method to address these problems has been social skills training. To date, the efficiency of this training is modest with respect to the transfer, maintenance and generalization of the newly learned skills. The goal of this study is to compare the profiles of behaviourally disordered (BD) students with non-behaviourally disordered (non-BD) students with respect to variables associated with social skills, psychosocial adjustment, physical activity and certain health habits. This correlational study uses a sample of 12-14-year-old students from the region of Que´bec City, which includes identified BD students as well students not identified as BD. Analysis of the results reveals that the BD students show lower levels of social skills, cooperation, self-esteem and self-efficacy. In addition, the results show that non-BD students participate in more organized sports activities than do their equally active BD peers, who tend to practice non-organized sports activities. In conclusion, the authors propose different intervention approaches for use in social skills training programmes for students with behavioural disorders.


There are many well documented problems facing the ordinary user, as opposed to the enthusiast, of Hypermedia (HM) technology which can lead these users to be frustrated by, or give-up using hypermedia technology altogether. Among these classic HM problems are: the Framing Problem, Framing And Intercomparision Combined, Link Types, Versioning And Historical Backtrack, Closed Context and Open Media, Adding These Aspects Later, Disorientation [3], Information Structuring Systems [2], Visualizing [4]. This paper focuses on one of these key problems, "the Framing Problem" - as the number of hypermedia objects grows the problem of restricting our attention to only the relevant connections becomes harder [3]. How can we structure the source hypermedia to show semantically related clusters? By solving this problem it is possible to offer new ways for people to search and browse hypermedia.


This Article explores how institutions in developing countries shape competition policy-making and regulatory reform, the implications of this process on the adoption of a pro-market strategy to promote development, and the implications of its application to a country transitioning from a command economy to a market economy such as China. Institutional analysis is important for two reasons. First, it enables us to highlight the decisive role of social arrangements in shaping the way a policy aimed at changing institutional structures, like competition policy, is understood and enforced. This is important because institutional change creates unexpected challenges as market forces increasingly replace central planning as the driving force in allocating social resources. If not properly addressed, such challenges could frustrate the whole transition process. Second, exploring the role of institutions the development of competition policy raises important and controversial issues of law and economics, which scholars have not yet settled. In particular, institutional analysis overcomes some of the limitations of conventional economic and legal theory, which, due to its excessive emphasis on logical positivism, has blinded policy-makers to the fundamental role of institutions' values and beliefs in enforcing social rules, thereby precluding a richer appraisal of social reality. Scholars usually agree institutions are defined by ideas, routines, and beliefs. But in order to assess their impact, we must examine the impact of these values and beliefs on the conduct of those involved in executing the policy. For example, we know that stronger institutions improve economic performance, but what does that imply? How do institutions


Over the last decade, there has been a significant increase in the number of clinical trials taking place in sub-Saharan Africa in a concerted effort to identify safe and effective prevention and treatment strategies to combat the heavy burden of infectious diseases in this region [1-3]. This is because numerous viral, parasitic and bacterial diseases are endemic in this region, including: 66% of the global HIV/AIDS infections, 31% of tuberculosis infections, and 86% of malaria cases [3, 4]. Routine capacity for clinical laboratory testing is also increasing in Africa. Clinical trials and clinical care in sub-Saharan Africa require accurate laboratory reference intervals for appropriate assessment of patients/participants, monitoring disease progression, and reporting of possible toxicity and adverse events.


Background: Circulating tumor DNA (ctDNA) is being evaluated as a tool to monitor disease and guide therapy escalation and de-escalation in advanced breast cancer. The patient, disease, and treatment characteristics that influence whether tumor DNA is isolated and sequenced from the bloodstream are not well understood. We aimed to describe patient and disease characteristics of cases with undetectable ctDNA levels despite progressive metastatic breast cancer (MBC). Methods: We retrospectively identified patients (pts) with MBC who had ctDNA evaluation by the Guardant 360 assay (Redwood City, CA) as part of their routine care from 2015-2020. We correlated the ctDNA assay with the disease status at collection. We identified the patient cohort with no detectable ctDNA despite evaluation at the time of progressive disease but prior to the initiation of a new therapy (ND ctDNA/PD) and compared the clinical, pathologic, and molecular features of this group to those with detected ctDNA. Differences were tested by two proportion z-tests. Results: Of 1151 ctDNA samples collected among 473 pts with MBC, 87 (7.5%) samples had no detectable (ND) ctDNA. 54 of 87 samples with ND ctDNA were collected at a time of stable or responding disease or after a new line of therapy was started, leaving only 33 ctDNA evaluations (2.8%) among 30 pts with ND ctDNA despite collection at the time of PD prior to new therapy. Among this group there were 14 pts (47%) with HR+ HER-, 11 pts (37%) with HER2+, and 5 pts (17%) with TN MBC. This compared to 254 pts (60%) with HR+ HER2-, 82 pts (19%) with HER2+, and 85 pts (20%) with TN MBC and detectable ctDNA. HER2-positive MBC was more common in the ND ctDNA/PD group than detectable ctDNA group (p-0.02). In the ND ctDNA/PD group, the median time from MBC diagnosis to ctDNA evaluation was 7 months and pts had received a median of 0.5 prior lines of therapy for MBC. Four pts (13%) had lobular breast cancer, 24 pts (80%) had recurrent disease, 14 pts (47%) had visceral metastases, and 12 pts (40%) had oligometastatic disease. Sites of metastases at the time of ND ctDNA/PD were bone n=16 (53%), lung n=7 (23%), liver n=6 (20%), lymph node n=11 (37%), skin and soft tissue n=5 (17%), and CNS n=5 (17%). When compared to those with detectable ctDNA these differences in characteristics were not statistically significant, although numerically pts with ND ctDNA had more CNS disease (17% vs 10%) and less liver disease (20% vs 32%). At the time of ND ctDNA, the site of progression was bone n=14 (47%), CNS n=5 (17%), lymph node n=9 (30%), lung n=7 (23%), and liver n=5 (17%). There was a single site of progression in 20 pts (67%). 16 of 30 pts had repeat ctDNA analysis of which 9 pts had subsequent detectable ctDNA with a median VAF of 0.3%, a median of 1 alteration per sample, and oncogenic or likely oncogenic alterations in TP53 in 3 pts and BRCA1, CCNE1, CDH1, and PIK3CA in 1 pt each. Seven had tissue NGS, all of which showed multiple oncogenic alterations. The remaining 22 pts with ND ctDNA but no PD were responding to therapy based on imaging or had already started a new therapy since the last progression. This group also had a high proportion of HER2+ MBC (n=7, 32%) and low proportion with visceral disease (n=6, 27%) Conclusions: Although ctDNA is a highly sensitive tool to detect active MBC (<3% of samples had ND ctDNA), its sensitivity may be less in some clinical scenarios, including HER2+ MBC, when there are limited sites of progression, or when there is isolated CNS progression.
 Citation Format: Ami N Shah, Lorenzo Gerratana, Shruti Chandra, Dhruvika Mukhija, Neelima Katam, Anthony K Kang, Andrew A Davis, Millen Srivastava, Saya Jacob, Paolo D'Amico, Qiang Zhang, Carolina Reduzzi, Michael Gurley, Firas Wehbe, William J Gradishar, Amir Behdad, Massimo Cristofanilli. Progressive metastatic breast cancer with no detectable circulating tumor DNA: Evaluating limitations of this highly sensitive tool [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-08-04.


during the process of industrialization, there is a homogenous tendency in Dongyang wood carving because of mechanized production and Dongyang wood carving has gradually lost its unique artistic charm. Using the attractive quality theory, the paper analyzes the quality elements of Dongyang wood carving and comes to a conclusion that, expect the quality elements that can reflect the practical values, such as materials, attractive quality elements that are attached to the practical values, such as carving art and culture, shall be explored to the greatest extent; the paper also believes that creative management is an important way to improve the attractive quality of Dongyang wood carving, furthermore, the paper proposes specific measures to strengthen the creative management of Dongyang wood carving enterprises. Keywords—Dongyang Wood Carving; Attractive Quality;


This paper presents a new low power BIST TPG scheme to make high correlative test pattern. It uses a transition monitoring window (TMW) that is comprised of a combination circuit block and a MUX. When random test patterns are generated by an LFSR, transitions of those patterns satisfy pseudo-random gaussian distribution. The proposed technique represses transitions of patterns using a k-value which is a standard that is obtained from the distribution of TMW to observe over transitive patterns causing high power dissipation in a scan chain. Experimental results show about 60% transition reduction without performance loss in ISCAS'89 benchmark circuits that have large number scan inputs.


Benjamin Towbin studied Molecular Biology at the University of Basel, Switzerland, before carrying out a Master's in Biomedical Sciences at the University of Utrecht, The Netherlands. He then pursued his PhD with Susan Gasser at the Friedrich Miescher Institute for Biomedical Research, Basel, studying the dynamics of subnuclear chromatin organisation during C. elegans development. For his postdoc, Benjamin joined Uri Alon's lab at the Weizmann Institute of Science, Rehovot, Israel, with funding from HFSP and SNSF to work on optimality principles in bacterial growth control. Following a second postdoc with Helge Großhans, funded by a Marie Skłodowska-Curie Individual Fellowship and by the Engelhorn Foundation, he set up his independent group in 2019 at the University of Bern, where he applies quantitative systems biology approaches to study optimality principles at a multicellular scale using C. elegans.


Over the past few years, different transport research establishments have adopted a common method for modeling road safety indicators. The Road Demand, Accidents and Their Severity (DRAG) model is used as the reference. Germany, France, Norway, Sweden and the State of California have recently taken up this approach albeit adapting it to their statistical particularities, on the one hand, and to their socio-economic and political environments on the other hand. The findings are expressed in terms of the elasticities of risk indicators as a function of explanatory variables that are common to the different models in the DRAG family. The risk factors retained here are those, which appear to be the most important, and which are shared between several models, so that a comparison can be made to their effects. These factors are classified by theme: risk exposure; driver behavior; and economic variables; divided between households' economic situation and the factors that influence the frequency and distance of people's journeys. The other groups of variables relating to the characteristics of the road traffic system (defined as the road network, the vehicle stock and users), to climatic conditions, to time-of-year variables and to regulatory measures are either limited to a single country, or to specific to one of the countries to bring any added value through a comparative analysis.


Purpose We aimed to investigate the role of QRS duration on the surface electrocardiogram (ECG) in predicting response to levosimendan therapy in patients with acute systolic heart failure. Methods Patients with an ejection fraction (EF) lower than 35% who required intravenous inotropic support despite optimal heart failure therapy were included in this study. Patients were divided into two groups according to QRS durations on ECG. Group 1 (n = 16) included patients with a QRS duration equal to or shorter than 120 ms and group 2 (n = 14) included patients with a QRS duration longer than 120 ms. New York Heart Association (NYHA) functional class, plasma BNP levels and echocardiographic measurements were compared within and between groups before and after the infusion. Results In both groups statistically significant improvement was observed in NYHA class, plasma BNP levels and left ventricular end-systolic diameter after the levosimendan infusion compared to baseline (P < 0.025). In addition, in group 1 patients, left atrial diameter, left atrial volume, left ventricular end-diastolic diameter, left ventricular end-diastolic volume, left ventricular end-systolic volume (LVESV), left ventricular EF, mitral E velocity, mitral annular Aa and Sa parameters improved after the infusion compared to the baseline values (P < 0.025). Comparison of both groups revealed improvement of NYHA class, an increase of left ventricular EF and a signficant decrease of LVESV after levosimendan in group 1 (P < 0.05). Conclusion QRS duration on ECG may be used as a practical bedside indicator in estimating short-term response to levosimendan therapy.


Drawing on the results of a national study and a series of focus groups, this article argues that most women, including welfare recipients, package income, that is, combine resources from men, the market, and the state to support their families. Accepting the concept of income packaging and incorporating it into social welfare policies would reduce the stigma attached to the receipt of welfare and, in the long run, would decrease the dependence of poor women and their families on welfare benefits.


This experiment infiltrated the PEG solution to study the cucumber seed's germination characteristic, meanwhile used pot of water to study the growth of physiological and biochemical.By measuring the growth of physiological and biochemical to study water stress on the growth of cucumber seedlings. Experimental results showed that :With the moisture stress intensifiesd, cucumber germination percentage, germination tendency,radical length, plumule length and long showed downward trend; the proline content was rising, and more serious water stress,the more obvious trend; Cucumber seedlings and chlorophyll content and peroxidase activity in the early moisture stress showed upward trend and decreased later, but compared with the control group, there was an increase.in moderate water,achieving maximum value; compared with the control group, cucumber leaves and total leaf area were a decline, moderate water stress downward trend minimum. Compared with the control group, the difference was not significant.


: Police affairs programs are an important branch of china's legal programs and an important window for china's current legal publicity and education. At present, China is carrying out the eighth five-year legal publicity and education, so the innovative development of police affairs programs will inevitably attract attention from all walks of life. In order to dispel the seriousness of police affairs programs, cater to the current audience's love, and promote the publicity and education of such programs, police affairs programs begin to develop innovative Guardian of Jiefangxi is a typical example in this context.


The increase of floating population has become an important population phenomenon of China.Currently,large scale population floating brings inevitable pressure and problem to Chongqing and law-violation phenomena of peasant-worker in Chongqing should be paid attention to.Law-violation phenomena of peasant-worker in Chongqing can be controlled by learning from the experience abroad,by protecting legal rights of peasant-worker based on Chongqing's real situation,comprehensive and scientific management and by constructing community and society integration.


Abstract Building B of Group II at Holmul, Guatemala, is well known in Maya archaeology for its unique series of superimposed tombs, some of which contain rare large deposits of ceramic material dating to the Terminal Preclassic period (a.d. 1–250). However, the building also contains large deposits of early facet Early Classic (a.d. 250–400) material, as well as the remains of a potential title holding elite. This article presents the current ceramic sequence for the Holmul region and a re-evaluation of the ceramic material from all rooms in Building B Group II in light of new discoveries at sites within the Holmul region and the greater Maya lowlands. The result is a new hypothesis about what social processes are manifested through Terminal Preclassic period orange slipped pottery, which suggests that the vessels associated with deposits in Buidling B may represent changes in elite diacritical feasting events during this period. These feasts, and the preparations made for them, may have simultaneously integrated social groups within a polity while also reinforcing differences between them during two turbulent epochs of Maya political history—namely, the late facet of the Terminal Preclassic period (a.d. 150–250) and the early facet of the Early Classic period (a.d. 250–400).


During spermatogenesis, the blood-testis barrier (BTB) undergoes cyclic remodeling which is crucial to support the transport of preleptotene spermatocytes across the immunological barrier at stage VIII-IX of the epithelial cycle. Studies have shown that this timely remodeling of the BTB is supported by several endogenously produced barrier modifiers across the seminiferous epithelium which include: the F5-peptide and the rpS6 (ribosomal protein S6, a downstream signaling molecule of the mammalian target of rapamycin complex 1 (mTORC1)) signaling protein. Herein, F5-peptide and a quadruple phosphomimetic (and constitutively active) mutant of rpS6 (i.e., p-rpS6-MT) that are capable of inducing reversible immunological barrier remodeling, by making the barrier "leaky" transiently, were used for their overexpression in the testis to induce BTB opening. We sought to examine if this facilitated the crossing of the non-hormonal male contraceptive adjudin at the BTB when administered by oral gavage, thereby effectively improving its BTB transport to induce germ cell adhesion and aspermatogenesis. Indeed, it was shown that combined overexpression of F5-peptide and p-rpS6-MT and a low dose-adjudin, which by itself had no noticeable effects on spermatogenesis, was capable of perturbing the organization of actin- and microtubule (MT)-based cytoskeletons through changes in the spatial expression of actin- and MT-binding/regulatory proteins to the corresponding cytoskeleton. These findings thus illustrate the possibility of delivering drugs to any target organ behind a blood-tissue barrier by modifying the tight junction (TJ)-permeability barrier using endogenously produced barrier modifiers using this adjudin animal model.


The purpose of this present study was to investigate the relationship between intrapersonal intelligence of EFL learners and their critical thinking. Multiple intelligences involve nine types and onc is intrapcrsonal intelligence. Intrapcrsonal intelligence refers to the ability to understand the concept of oneself and awareness of fears, attendance, and information about life decision making. In educational settings, the central aim of an education system is leaming to think. Critical thinking is an active, intellectual process where the individual will observe, analyze and reflect on new knowledge and integrate it into their current understanding. To fulfill this objective, the research was conducted with 50 female students studying in Grade Three at Hazrate Masome high school in Farashband. To evaluate the students' intrapersonal intelligence, a questionnaire consisting of lO-items from Smart Cubes Test was administered. A critical thinking questionnaire adapted from Naieni (2005) which was given to the participants based on Honey's (2004) critical thinking questionnaire was employed. The results showed no significant relationships between intrapersonal intelligence of students and their critical thinking.


Divisao de Pneumologia, Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil; Instituto de Ensino e Pesquisa, Hospital Sírio Libanes, São Paulo, Brazil; Disciplina de Anestesiologia, Departamento de Cirurgia, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil Correspondence to: Mauro Roberto Tucci, MD, PhD. Laboratório de Pneumologia (LIM 09), Faculdade de Medicina, Universidade de Sao Paulo, Av. Doutor Arnaldo, 455 (Sala 2144, 2nd floor), São Paulo 01246-903, Brazil. Email: email@example.com. Provenance and Peer Review: This article was commissioned by the editorial office, Annals of Translational Medicine. The article did not undergo external peer review. Comment on: Liu K, Huang C, Xu M, et al. PEEP guided by electrical impedance tomography during one-lung ventilation in elderly patients undergoing thoracoscopic surgery. Ann Transl Med 2019;7:757.


Myocardial infarction (MI) is a manifestation of coronary artery disease where coronary blood supply drastically reduced or interrupted. It is a lethal and emergency cardiovascular disease which is one of leading causes of disability and death in clinical practice (Kerr, 1994). Ventricular remodeling after myocardial infarction refers to neuro-hormonal and genetic regulatory mechanisms activated by inflammatory cytokines causing changes in quality of cell morphology and functions of myocardial cells (Majno et al., 1995; Kerr Necrosis, apoptosis, myocardial fibrosis and scarring after acute myocardial infarction can be factors to reduce the function of the myocardial cells leading to heart failure. Many mode of treatment have been introduced for myocardial infarction. Regeneration of infarcted myocardial cells inhibition of myocardial apoptosis has become the different mode of treatment for ischemic heart disease. designed to investigate the influence of allogeneic bone marrow mononuclear cells (BM-MNC s) tra myocardial apoptosis in rats after acute myocardial infarction (AMI).


We investigate a class of Lie algebras called quasi-simple Lie algebras. These are generalizations of semi-simple, reductive, and affine Kac-Moody Lie algebras. A quasi-simple Lie algebra which has an irreducible root system is said to be irreducible and we note that this class of algebras have been under intensive investigation in recent years. They have also been called extended affine Lie algebras. The more general class of quasi-simple Lie algebras has not been so intensively investigated. We study them in this paper and note that one way they arise is as fixed point subalgebras of finite order automorphisms. We are able to show that the core modulo the center of a quasi-simple Lie algebra is a direct sum of cores modulo centers of some indecomposable quasi-simple Lie algebras. 0. Introduction In 1990 Høegh-Krohn and B Torresani [HK-T] introduced a new interesting class of Lie algebras over field of complex numbers, called quasi simple Lie algebras (QSLA for short) by proposing a system of fairly natural and not so much restrictive axioms. These Lie algebras are roughly characterized by a symmetric nondegenerate invariant bilinear form, a finite dimensional Cartan subalgebra, a discrete root system and the ad-nilpotency of the root spaces attached to non-isotropic roots. In [HK-T], the authors extract some basic properties of QSLAs from the axioms, but for the further study of such Lie algebras they assume the irre-ducibility of the corresponding root systems. Namely, a QSLA is called irre-ducible if the set of non-isotropic roots is indecomposable and isotropic roots are non-isolated (see Definition 1.11 for terminology). Following [AABGP], we call an irreducible QSLA an extended affine Lie algebra (EALA for short). We note that EALA have been under intensive investigation in recent years,


Network coding has been proven as a very promising technique to improve wireless network throughput. In multi-rate wireless networks, simply seeking more coding opportunities or encoding more packets into one frame without exploiting multi-rate feature may lead to selecting low-rate links for transmission, and thus compromise the performance gain brought by network coding. In this paper, we aim at exploiting the potential benefits brought by both multi-rate and network coding. We carefully address the bottleneck problem in applying network coding to multi-rate networks, and propose Network Coding with Relay Assistance, called NCRA. We design a Medium Access Control (MAC) protocol based on 802.11 DCF to implement the idea of NCRA. Numerical results of both analytical modeling and simulation experiments based on NS-2 demonstrate that NCRA can significantly improve network performances in terms of both throughput and end-to-end delay, at a relatively low cost of header overhead.


The implementation of Total Productive Maintenance (TPM) is to improve maintenance performance in the production machine at PT. Multi Karya Persada Indonesia In Kapuas Regency, Central Kalimantan This is descriptive research. The analysis used overall equipment effectiveness (OEE), OEE six big losses, Pareto diagrams, and cause and effect diagrams. As a result of PTPN VI PT. Multi Karya Persada Indonesia  In Kapuas Regency, Central Kalimantan had a problem with machine performance value, it was lower than the world-class standard of about 71.85% (≤ 95%). Caused of the low OEE value (65,16%) is high idling and minor stoppages and reduced speed losses value. To improve this problem the company is implementing TPM, with planning 8 TPM pillars as the foundation for implementing TPM.


Background  As the use of the Internet increases, it is important to gain insight into how it is used by patients to obtain health‐related information.