Objective:To observe the cardiac function,MMP9 and TIMP1 protein expression in myocardium in adjuvant arthritis rats.Methods:24 rats were randomly divided into control group(NC) and model control group(MC).Except for control group,the rats of model control group were induced to AA model by intradermally injecting Freund′s complete adjuvant into the right paw.48 days after inducing AA model,the swelling degree of voix pedis and arthritis index(AI) were observed in rats.Cardiac function was detected by the small animal multi-channel physiological recorder and heart echocardiography.Heart tissue pathological were observed by HE staining and matrix metalloproteinase-9(Matrix metallo proteinase 9,MMP-9),matrix metalloproteinase inhibitor-1(Tissue inhibitor of metallo proteinase-1,TIMP-1) expression of the protein were detected by immunohistochemistry staining in AA rats.Serum cytokines were measured by ELISA method and the expression of regulation T cells(Treg) were observed by flow cytometry.Results:①Compared with those in NC group,MC group declined inflammatory 12 d weight,weight loss on inflammatory 48 d to peak;18 d inflamed paw swelling reached its peak.② Compared with those in NC group,E peak,E/A,FS% of MC group were significantly lower(P0.05 or P0.01),A peak was significantly higher(P0.01).Compared with those in NC group,HR,HI,left ventricular end systolic pressure(LVSP),left ventricular end diastolic pressure(LVEDP) of MC group increased significantly(P0.05),left ventricular pressure rise / fall maximum rate(± dp/dtmax) were significantly lower(P0.05).③ Compared with those in NC group,TNF-α,BNP,IL-17 of MC group were significantly higher(P0.05 or P0.01),IL-10,CD4+ Treg,CD4+ CD25+ Treg were significantly lower(P0.01).④ Compared with those in NC group,cross-sectional myocardial cell diameter values(TDM/μm) of MC group was significantly higher(P0.05),MMP-9 expression in MC was significantly higher in myocardial cells,significant difference(P 0.01),while TIMP-1 expression level was significantly lower(P0.01).⑤ Spearman correlation analysis showed that,cardiac function in AA rats with peak E and TIMP-1,peak A and TIMP-1,HI and AI,﹢dp/dtmax and TIMP-1 were positively correlated(P0.05).Peak A and MMP-9,+dp/dtmax and IL-17,-dp/dtmax and IL-10 showed a significant negative correlation(P0.05).Conclusion:The cardiac function of AA rats was reduced.The mechanism may be results from inflammation of AA rats which showed a high sensitive response to antigen stimulation and disorder of immune regulation,released of a large number of cytokines and inflammatory mediators,leaded to damage of local joints as well as cardiac cells and extracellular matrix.Finally,cardiac function was reduced in AA rats.


CASE tools based on EERD modeling are major applicated on development of database application. These tools could improve the efficiency and accuracy of the developing database application greatly. This paper particularly describes the basic architecture and function of CASE tools in this field as well as the implement technology, and presents the whole structure of the concept data model of the data dictionary included by CASE tools through the analyse of sorts of CASE tools in prevalence, and also illustrate the relationship of model elements which compose the concept data model.


Prediction of evapotranspiration is important for study, design and management of irrigation systems. In this study, the potential of Multiple Linear Regression model using least squares is investigated in modeling of mean monthly evapotranspiration (PET) obtained using the standard FAO-56 Penman-Monteith equation. Various combinations of daily climatic data, namely solar radiation, air temperature, relative humidity and wind speed, are used as inputs to the model, so as to evaluate the degree of effect of each of these variables on PM estimated PET. Residual Analysis, Co-efficient of Determination and Residual Error is used as comparison criteria for evaluation of the model performance. The Multiple Linear Regression model gave Residual errors of 0.83mm/day and Co-efficient of Determination of 0.995 for the meteorological station considered. Based on the residual analysis results it was found that the Multiple Linear Regression model followed a linear trend. The input variables of the model were adequate and this model could be successfully employed in estimating the monthly Potential Evapotranspiration in the study area.


The learning outcomes of mathematics are one of the benchmarks of the high and low quality of a mathematics learning process. This study aims to find out how the effectiveness of STAD type cooperative learning model with the help of worksheets on mathematics learning outcomes of class VIII students at MTs. Muhammadiyah Palleko in Takalar in 2014/2015 academic year. This research is quasi-experimental or quasi-experimental research. The instrument used in this study is the essay type learning test with a sample of 35 people, and the sampling technique used is saturated samples. The data analysis technique used is descriptive statistical analysis and inferential statistical analysis. Based on the results of descriptive analysis obtained the average of the two groups, namely the experimental class before treatment (pre-test) of 59.16 and after the surgery of (posttest) 75.61, the average pre-test control class was 54.56, and the post-test average is 58.25. Whereas based on the results of relative efficiency and inferential analysis it can be concluded that the STAD type of cooperative learning model with the help of LKS is effective in improving the mathematics learning outcomes of the eighth-grade students of MTs. Muhammadiyah Palleko District of Taylar.


I can see that Dr Rajakumar must surely be missed as anexceptionally inspiring role model and leader in family practice.I can understand that the grief you feel after his death inNovember 2008 must still be strong. I very respectfully passon the heartfelt condolences of the Royal Australian Collegeof General Practitioners. This morning I wish to speak to you about the world's evolvingunderstanding of just what primary care has to offer. DrRajakumar was indeed ahead of his time as he understoodthe power of primary care long before most others. (copied from article)


The interaction of a few-cycle pulse with a substance, described in terms of density matrix formalism, is investigated numerically. The influence of disordered layered structure, covering the substance, is studied. The material of disordered structure is assumed to be linear and is described in terms of classic electrodynamics. The appearance of additional spectral features, unrelated to the substance material, is demonstrated.


" Combustion synthesis and spark plasma sintering of high emissivity ZrO 2 /graphene ceramic as imitated moxibustion emission source " Vol. 130, No. 2, p. 199 – 203 In the process of physical therapy, the medicinal e ff ect of traditional moxibustion is as important as the photothermal e ff ect. The nature of the photothermal e ff ect is achieved by the interaction between the high temperature emission spectrum of the moxa stick burning surface to reach an equilibrium temperature of 470°C and the human acupoints. Using mixed Mg powder and ZrO 2 powders as raw materials, the MSZ/G composite powder is prepared by combustion synthesis in CO 2 gas of high pressure. The powder is sintered and by SPS to obtain densi fi ed MSZ/G composite ceramic block. After component optimization, its emission spectrum at high temperature can achieve accurate fi tting of the spectrum of moxibustion. The intelligent moxibustion instrument using MSZ/G composite ceramic block as the high-temperature emission source can replace moxibustion and achieve highly simulated treatment e ff ect of moxibustion.


We tested a neural model for variable estimation on a benchmark corresponding to a subsystem of the 320 MW power plant located at Piombino, Italy, namely one of the high pressure feedwater lines. The process simulation is based on a physical approach and was validated on real plant data. The experiments concern the estimation of the dynamic behaviour of seven state variables for the last heater in the feedwater line. The chosen neural model is a modified Resource Allocating Network. The Neural State Estimator (NSE) is structured as a MIMO (Multi Input Multi Output) neural net, able to estimate all the state variables at the same time. The NSE was tested on a realistic amount of data, obtaining industrially relevant results, much better than those obtained by classical estimation methods.


The Stochastic Model definition in the frame of absolute positioning applications is frequently reduced to the computation of diagonal (variances) elements assuming that non-diagonal elements (covariances) are negligible. This assumption could be challenged during Ionospheric Scintillations and the design of a more complete and advanced stochastic model could improve positoning performances during such circumstances.


Convergent Evolution in Livebearing Fishes. (May 2012) Nicholas Joseph Troendle, B.S., Pepperdine University Co-Chairs of Advisory Committee: Thomas J. DeWitt, Mariana Mateos The directionality and consistency of evolution has long been a subject of contention among evolutionary biologists since the days of Darwin. However, it is unknown how much can be quantified and how much results from more complex variables. It is also unknown whether evolution is consistent or whether it occurs differently in each system. My study focuses on predation and habitat as ecological gradients that may create convergent evolution in livebearing fishes. In Chapter I, I focus on predation as a mechanism for driving convergent evolution in Gambusia affinis. A suite of 7 microsatellite markers was used in order to determine independence of morphological evolution. Mantel tests were used to compare genetic, phenotypic, geographical and environmental distances among the six focal populations. These tests showed that there was a significant correlation between genetic and geographic distance but no significant correlation between genetic and phenotypic distances, which may indicate that phenotypic divergence has arisen independently in multiple instances.


Subtitle: Fleet management can be an invisible function for many senior executives. Proactive fleet managers communicate how their function contributes to the company's overall goals and bottom line.


The technological process for extracting compound "tea-flavone" from green tea or olong tea includes the following steps: soaking, recovering solvent, extracting tea-polyphenol, catalytic reaction and extraction. The obtained product uses ester type catechin (EGCG, ECG) as its main component, and its content can be up to above 90% (removing caffeine). As compared with existent tea-polyphenol it possesses strongs resistance to oxidation, better stability and higher product purity, and can be dissolved in solvents of water, alcohol, methyl alcohol and ethyl ether, and its aqueous solution is yellow-orange colour. It possesses extensive application fields of beverage, medicine, health-care product, food, chemical and radiation-proofing articles.


Classroom teaching of chemistry conceptian must be in accordance with the rules of learning chemistry conception.Based on this,we present classroom teaching procedure about chemistry conception:guidance-examplification-definition-preliminary application-appraisement.


Introduction: The central nervous system involvement in Behçet's disease occurs in 5–30% of cases. The diagnosis of pseudotumor cerebri is even rarer (only 22 cases reported worldwide). Purpose: To emphasize the importance of differential diagnosis in a case of pseudotumor cerebri in the context of ocular inflammation. Methods: V.A.V.R., a 31 year old female, was diagnosed with pan-uveitis on the left eye associated with recurrent bipolar aphthosis. During the etiological investigation, there was an onset of a left hemiparesis and facial palsy. Results: The central nervous system (CNS) neuroradiological investigation revealed a space-occupying lesion within the right hemisphere with intense signal enhancement with gadolinium. It globally reached the nucleo-basal structures and induced deviation of the middle structures (including homolateral ventricle). Cytochemical analysis of cerebrospinal fluid (CSF) was negative for atypical cells. The ophthalmological features regressed with the corticosteroid and immunosuppressive therapy instituted. The final diagnosis was of pseudotumor cerebri in the context of Behçet's disease. Conclusion: In Behçet's disease, a cerebral space-occupying lesion should lead to a diagnosis of pseudotumor cerebri. The correct diagnosis will determine an appropriate therapy and may prevent an inappropriate neurosurgical approach. The cortico and immunotherapy allowed a substantial regression of the lesion.


The Ben Beinart Memorial Lecture given at the University of Cape Town on 16 April 2013. The paper discusses the 1804 case of Cadell & Davies v Stewart, in which the existence of rights to publish or to prevent publication of private letters between the poet Robert Burns and his close friend Agnes McLehose was ventilated at length by the advocates and judges appearing in the court. The paper assesses the evidence for what really happened between Burns and Agnes, and discusses the contemporary significance of the court's decision to prevent publication.


The purpose of this work is to compare and assess, more in terms of computational efficiency than in terms of accuracy, three alternative implementations of a boundary formulation based on the Trefftz method for linear elastostatics, namely a collocation-based and two Galerkin-based approaches. A finite element approach is used in the derivation of the formulation for the Galerkin-based alternative implementations. The coefficients of the structural matrices and vectors are defined either by regular boundary integral expressions or determined by direct collocation of the trial functions. Numerical tests are performed to assess the relative performance of the different alternative implementations.


Disclosed are a novel indolium compound represented by the general formula (I) below and an optical recording material using such an indolium compound. (I) (In the formula, ring A represents a benzene ring or the like; ring B represents a five-membered or six-membered heterocyclic ring; Rrepresents a group represented by the general formula or the like; Rrepresents an organic group having 1-30 carbon atoms or the like; Yrepresents an alkyl group having 1-10 carbon atoms or the like; Zand Zeach represents an alkyl group having 1-8 carbon atoms, which may be substituted with a halogen group or interrupted by-O-or the like, or the like; a represents an integer of 0-6; b represents an integer of 0-5; Anrepresents a q-valent anion; q represents 1 or 2; and p represents a number required for maintaining electrical neutrality)


Defining strategic position of the organizations within the industry environment is one of the basic and most important phases of strategic planning to which extent that one of the fundamental schools of strategic planning is the strategic positioning school. In today's knowledge-based economy and dynamic environment, it is essential for universities as the centers of education, knowledge creation and knowledge worker evolvement. Till now, variant models with different approaches to strategic positioning are deployed in defining the strategic position within the various industries. Balanced Scorecard as one of the powerful models for strategic positioning, analyzes all aspects of the organization evenly. In this paper with the consideration of BSC strength in strategic evaluation, it is used for analyzing the environmental position of the best's Iranian Business Schools. The results could be used in developing strategic plans for these schools as well as other Iranian Management and Business Schools. Keywords—Strategic planning, Strategic position, Balanced scorecard, Higher education institutions.


Significance Acute myeloid leukemia is a disease that lacks effective therapies, especially in postremission patients. Immunotherapies directed against a lineage-specific antigen (LSA), such as CD33 has demonstrated on-target effects on AML cells but is limited by toxicities because normal myeloid cells and hematopoietic progenitors also express CD33. Here we show that genetically ablating CD33 in human stem/progenitor cells, using Cas9/guide RNA mediated strategies, enables immunotherapy against leukemias using anti-CD33 CAR-T or antibody therapy. We model a postremission human marrow with minimal residual leukemic disease in mice and show effective clearance of acute myeloid leukemia and the reconstitution of the CD33-deleted human graft, enabling future clinical studies. This study presents an approach to treat myeloid leukemias and could be extended to other cancers and other antigens. Antigen-directed immunotherapies for acute myeloid leukemia (AML), such as chimeric antigen receptor T cells (CAR-Ts) or antibody-drug conjugates (ADCs), are associated with severe toxicities due to the lack of unique targetable antigens that can distinguish leukemic cells from normal myeloid cells or myeloid progenitors. Here, we present an approach to treat AML by targeting the lineage-specific myeloid antigen CD33. Our approach combines CD33-targeted CAR-T cells, or the ADC Gemtuzumab Ozogamicin with the transplantation of hematopoietic stem cells that have been engineered to ablate CD33 expression using genomic engineering methods. We show highly efficient genetic ablation of CD33 antigen using CRISPR/Cas9 technology in human stem/progenitor cells (HSPC) and provide evidence that the deletion of CD33 in HSPC doesn't impair their ability to engraft and to repopulate a functional multilineage hematopoietic system in vivo. Whole-genome sequencing and RNA sequencing analysis revealed no detectable off-target mutagenesis and no loss of functional p53 pathways. Using a human AML cell line (HL-60), we modeled a postremission marrow with minimal residual disease and showed that the transplantation of CD33-ablated HSPCs with CD33-targeted immunotherapy leads to leukemia clearance, without myelosuppression, as demonstrated by the engraftment and recovery of multilineage descendants of CD33-ablated HSPCs. Our study thus contributes to the advancement of targeted immunotherapy and could be replicated in other malignancies.


Gas chromatography is used to systematically analyze crylic acid and explore the separation of its inhibitor and different components.The inhibitor and components of crylic acid can be determined simultaneously by one injection,which provides a rapid and efficient method for the determination of industrial crylic acid.


Dual-output three-switch inverter topology is proposed in this paper. To supplying two single-phase ac loads independently with one inverter. Using reduced switch count topology which introduced in three phase converter. This configuration required less no of devices and provide dual output compared to conventional inverters. Which results in reduction in cost, size and switching losses. The proposed topology is introduced with its gate circuit for switching schemes is elaborated. Simulation model of proposed inverter is developed. Its output waveforms are analyzed. Total harmonic distortion and performances are compared with different PWM techniques. Key wordsReduced switch count inverter, three-switch inverter legs.


A new method is presented for determining the atmospheric optical thickness, aerosol scattering function, and surface albedo using measurements of the upward radiance at different view angles. It is applicable over the surface with reflectance not exceeding /spl ap/10%. The suggested approach is based on forming the data bank of aerosol scattering functions, complete enough in a sense of describing the real diversity of atmospheric phase functions both over sea and land. A performed sensitivity study shows that the error of determining the optical thickness does not exceed 10-15%. Aerosol absorption and anisotropy of the surface in typical conditions can induce additional errors up to 10 and 15%. Over the surface of Lambertian type, albedo is retrieved with an error less than 0.01, whereas over the anisotropic surface, it turns out to be close to the product of the hemispheric surface albedo and a factor of surface anisotropy. For the typical viewing geometry, characterized by fixed azimuth and varying zenith view angle, this method gives the best choice of scattering function from the data bank in a sense of proximity of its shape and anisotropy factor to those of the true atmospheric scattering function. Experimental applications of the method to the multiangle data of spectrometer MKS-M2, collected over the Caspian Sea, shows its utility in the remote sensing of atmospheric aerosol and surface albedo.


We investigated the current trends and outcomes of diabetic patients listed for heart transplants in the U.S. and provided a method for risk‐stratification.


Separable connector is used for connecting a cable to a switch gear in new energy generation sites because of its compact size. One of terminations of cable shield is not sometimes earthed in order to reduce power loss due to shield current. A part of the separable connector made up of semi- conducting material is connected to an earthing system. Furthermore, the end of the shield layers of the cable contacts with semiconducting material of separable connector. The shield layer of a cable might be regarded to be connected to the earthing system through resistance. Hence, the authors carried out impulse tests for separable connector with cable. This paper presents some remarkable results. Lightning overvoltage causes a serious damage in the semiconducting layer of separable connector when one of the terminations of the cable shield is not earthed. An effective method not to cause a damage in the semiconducting layer of the separable connector is the use of a surge protective device between the earth terminal of a separable connector and cable shield.


PURPOSE: A photo-resist composition, a method for forming patterns using the same, and a method for manufacturing a thin film transistor substrate using the same are provided to prevent the delamination of photo-resist patterns after an etching process. CONSTITUTION: A photo-resist composition includes an alkali soluble resin, a photo-sensitive compound, a compound represented by chemical formula 1, and a solvent. In the chemical formula 1, the R is hydrogen C1-C1 alkyl group, C4-C8 cycloalkyl group, or benzene group. A method for forming patterns using the composition includes the following: A photo-resist film is formed on a film to be etched by applying the composition. The photo-resist film is exposed by the irradiation of light. The photo-resist film is developed to form photo-resist patterns. The photo-resist pattern is used as an etching mask to etch the film to be etched.


In this paper,the effect of various inhibitors,such as disodium hydrogen phosphate,citric acid and sodium silicate,on flotation separation performance of powder quartz and andalusite was investigated by using sodium oleate as the flotation collector.The results showed that disodium hydrogen phosphate was an efficient inhibitor for separating andalusite from powder quartz.When the concentration of disodium hydrogen phosphate was set to the optimum one of 0.47×10-2 mol/L and the pH of flotation liquid to 8.5,the recovery difference between andalusite and powder quartz was as high as 47.86%.The results of infrared spectra and Zeta potential analyses revealed that the interaction between sodium oleate and andalusite powder resulted from the physical and chemical adsorption,while that between sodium oleate and powder quartz was due to the physical adsorption,suggesting that sodium oleate was more efficient in collecting andalusite.Also disodium hydrogen phosphate was found to play the role of desorption of powder quartz from sodium oleate,consequently inhibiting the flotation of powder quartz and resulting in the flotation separation of powder quartz from andalusite.


TAK‐778, a derivative of ipriflavone, has been shown to induce bone growth in in vitro and in vivo models. However, there are no studies evaluating by which mechanism TAK‐778 exerts its effect. Considering the evidences that its precursors act via classical estrogen‐receptor (ER)‐mediated signaling, in the present study, we tested the hypothesis that TAK‐778 induces osteogenesis in human bone marrow cell culture via an ER‐dependent pathway. Cells were cultured in 24‐well culture plates at a cell density of 2 × 104 cells/well in culture medium containing: TAK‐778 (10−5 M), Tamoxifen (10−5 M), TAK‐778 (10−5 M) + Tamoxifen (10−5 M), and vehicle. During the culture period, cells were incubated at 37°C in a humidified atmosphere of 5% CO2 and 95% air. At 7, 14, and 21 days, cell proliferation, cell viability, total protein content, alkaline phosphatase (ALP) activity, and bone‐like formation were evaluated. Data were compared by two‐way ANOVA and Duncan's multiple range test. TAK‐778 did not affect cell viability. Cell number was reduced by TAK‐778. Total protein content, ALP activity, and bone‐like formation were increased by TAK‐778. In general, Tamoxifen did not have any effect on cell behavior. However, when cells were cultured in medium containing both TAK‐778 and Tamoxifen, the effect of TAK‐778 on osteoblast differentiation was inhibited. The present results show that TAK‐778 enhances osteoblast differentiation in human bone marrow cell culture, at least in part, via an ER‐dependent pathway, since its effect was inhibited by Tamoxifen, a well‐known estrogen receptor antagonist. © 2004 Wiley‐Liss, Inc.


In the present study, there is a need to reduce the consumption of conventional fuel and related fossil fuels. So, in order to promote the use of renewable sources such as biofuels there is a requirement for the effective evaluation of the performance of engines based on the second law of thermodynamic. In this paper, the analysis of energy, exergy, mean gas temperature and exhaust gas temperature of a compression ignition (CI) engine using diesel and Karanja methyl ester blends are done. The results are calculated at various compression ratios under full load and at different engine loads at a compression ratio of 18:1. It is observed that the exergy efficiency, mean gas temperature, brake thermal efficiency increases with increase in compression ratio as well as load. The exhaust gas temperature and destruction of exergy decreases with increase in compression ratio and increases with increase in load for all blends of fuel.


This article draws from a larger study that examines the multiple literacies inherent in children's drawings. The author discusses a qualitative research project conducted with a split grade one and two classroom in Toronto, Canada. She argues that pictorial images can be read as a form of literacy, where thought is made public through visual narratives. The author's prime focus was to interpret the children's artwork as communication on a par with other semiotic modes and to explore the images as an important vehicle for teaching and learning.


Un-ionized ammonia (UIA) in freshwater is a primary source of toxins that kill freshwater fish. Concentrations as low as 0.03 mg/L can harm fish and concentrations of more than 2.00 mg/L can kill them. The availability of water quality monitoring systems that can directly measure UIA without any chemical treatment on samples is limited. This paper designs a new system by using a programmable system on chip and nondestructive types of measurement instruments. Four water environment parameters are measured, namely, pH, temperature, dissolved oxygen, and ammonium. Algorithms are applied on the system to calculate the UIA using data from the measurement instruments. The designed system can measure UIA in freshwater at 95% confidence level. Data from the system are monitored and recorded using a data acquisition system.


Background and purpose:  Disturbances in pulmonary vascular reactivity are important components of inflammatory lung disease. Haem oxygenase‐1 (HO‐1) is an important homeostatic enzyme upregulated in inflammation. Here we have investigated the potentially protective effect of HO‐1 against cytokine‐induced impairment in pulmonary artery relaxation.


Abstract For non-minimum phase plants, a partial LTR design of optimal output disturbance cancellation controllers is discussed. A target recoverable by the partial LTR procedure is identified as an output injection with a frequency-shaped gain matrix. The partial LTR result is used to clarify system-theoretic meaning of enforcing the minimum phase LTR procedure. It is shown that the partial LTR procedure provides more design freedom in shaping target feedback property than the enforced minimum phase LTR procedure.


Circulating fluidized bed (CFB), due to its unique advantages such as high fuel flexibility and low pollutant emission, has become a competitive technology for coal combustion. With the fast development of the computational fluid dynamics (CFD) technology, the numerical simulation has become a significant method to study the complicated characteristics of the CFB system. On the basis of a pilot-scale 50 kWth CFB combustor, this Article develops a comprehensive three-dimensional CFB coal combustion model under the air atmosphere by the Eulerian–Eulerian approach. Good agreement is observed for the general behaviors of the CFB combustor between simulated results and experimental data. A full-physics picture including flow structure, temperature, and gas composition in a three-dimensional space of the pilot-scale CFB combustor is provided. The simulation in this Article helps in a better understanding of the CFB combustion.


Ecological environment in North-west of China is fragile. Urbanization strategic environmental assessment will be contributed to find the best point between environment protection and urbanization in North-west of China, which will promote the sustainable development in North-west of China. This paper expounds the target of urbanization strategic environmental assessment based on environment analysis , studies the mechanism of urbanization strategic environment influence ,the influence factors and assessment index system.


Large numbers of the three-cornered alfalfa hopper, Spissistilus festinus (Say), were successfully reared on soybean and alfalfa plants in a greenhouse. The pre-oviposition period of this insect in the greenhouse averaged 14.1 days. The incubation period ranged from 6 to 27 days and averaged 16.5 days. An average of 37.7 nymphs hatched from eggs laid by each female. Time required for nymphal development in bioclimatic chambers and in a greenhouse averaged 21.89 and 23.57 days, respectively. Measurements of each instar are given.


In this work we come up with two fully homomorphic schemes. First, we propose an IND-CPA secure symmetric key homomorphic encryption scheme using multivariate polynomial ring over finite fields. This scheme gives a method of constructing a CPA secure homomorphic encryption scheme from another symmetric deterministic CPA secure scheme. We base the security of the scheme on pseudo random functions and prove the scheme to be IND-CPA secure, rather than basing security on hard problems like Ideal Membership and Gröbner basis as seen in most polly cracker based schemes which also use multivariate polynomial rings. This scheme is not compact but has many interesting propertiesIt can evaluate circuits of arbitrary depths without bootstrapping for bounded length input to the algorithm. Second, we also describe another similar symmetric key scheme which is compact, fully homomorphic and doesn't require bootstrapping. The scheme is on the lines of the work of Albrecht et. al. (Asiacrypt-2011) and is proven to be bounded CPA secure. Proof is based on Ideal Membership/ Ideal Remainder/Gröbner basis problem.


Using information about objects of surround environment is a good way not only for detecting obstacles but also for estimation of relative translation. Hight-speed lidars provide a lot of information for performing this tasks. But matching one scan to another in some cases lead to different problems. In this paper we describe the solution for building occupancy maps, aligning one scan with another using only information from lidar and processing all data in the real-time using GPU.


The training system of the volunteer fire-fightersTo enable fire-fighters to successfully fulfill their responsibilities, they need to constantly improve their skills and broaden their knowledge to help society and to be ready to deal with the new civilization hazards and threats. The legislation of the fire safety law regulations in the 1991 enforce to organize the new education system both for the professional fire management officers and the commanders of the volunteer fire units. Moreover it enables to acquire the new qualifications on the field of the fire safety equipment such as: hydraulic equipment, lifting bags, thermal camera, multi-gas sensor detector.All of those qualifications are necessary to broaden the scope of the responsibilities of the volunteer fire-fighters on the area of different specialization, where the common professionalism of firefighters can improve the efficiency of rescue actions.


Background: Research suggests that head ‐ mounted displays (HMD) can spark situa-tional interest when they are used to provide science learning experiences that are not possible in traditional classroom settings. However, few studies have investigated the lasting effects of using HMDs in an authentic instructional intervention. Objectives: We investigated the effects of a one ‐ time experience of a virtual field trip to Greenland in a sample of 105 middle school students. Methods: Students used either a standard 2D video (video condition; N = 50) or an HMD (HMD condition; N = 55) as part of a six ‐ lesson educational activity on the topic of climate change. Informed by social cognitive career theory (SCCT), we investigated the effects of the different conditions (video vs. HMD) on the outcomes of self ‐ efficacy, outcome expectations, interest, and science intentions across three time points. Results and Conclusions: The results showed that using the HMD ‐ based virtual field trip, compared to the video, had a positive immediate effect on self ‐ efficacy and interest, and total later effects on self ‐ efficacy, outcome expectations, and interest an average of two and a half weeks after the virtual field trip. The results suggest that HMD ‐ based virtual field trips can influence self ‐ efficacy, outcome expectations, and interest more than a video ‐ based virtual field trip when measured approximately two and a half weeks after the intervention.


The utility model discloses a material feeding tank capable of synchronously providing coal to a plurality of gasification furnaces, which has high space utilization and can effectively avoid bridgingof coal powder in the material feeding tank. In the cylindrical material feeding tank, a multi-channel fluidizing air pipe (2) and the separated air chambers of a cylindrical material tank body (1) are connected, a set of tapered grid plates (3) are arranged above the air chamber, each grid plate (3) corresponds to one channel of fluidizing air pipe (2) and a discharge pipe (4) is arranged aboveeach grid plate (3), each channel of discharge pipe (4) is provided with a discharge controlling valve (7), a pressurized air pipe (5) is arranged above the cylindrical material tank body (1), a supplementary air pipe (6) is arranged at the outlet of each discharge pipe, and a coal breaking hole (8) is arranged above the cylindrical material tank body (1); each channel of the fluidizing air pipe (2) is provided with a fluidized air controlling valve (9); each supplementary air pipe (6) is provided with a supplementary air controlling valve(11), and the pressurized air pipe (5) is provided witha pressurized air controlling valve (10).


Residual stresses due to welding in reactor pressure vessel (RPV) top head nozzle penetrations have been predicted using finite element analysis since the early 1990s. While the analyses were originally targeted at calculating nozzle stresses, the finite element methods have been extended to model a number of different aspects of RPV head penetrations. Both top and bottom head penetrations have been modeled, and the effects of J-groove butter weld deposition and subsequent thermal stress relief of the top head are now included in the analytical model. Development work has recently been completed to integrate a fracture mechanics model into the welding residual stress model. This has allowed for the prediction of crack tip stress intensity factors in the presence of welding residual stresses that include the effects of stress redistribution due to the presence of the crack. This paper presents some of the modeling techniques used in these recent analyses, and some key results obtained.Copyright © 2004 by ASME


A major discovery of Parker Solar Probe (PSP) was the presence of large numbers of localized increases in the radial solar wind speed and associated sharp deflections of the magnetic field—switchbacks (SBs). A possible generation mechanism of SBs is through magnetic reconnection between open and closed magnetic flux near the solar surface, termed interchange reconnection, that leads to the ejection of flux ropes (FRs) into the solar wind. Observations also suggest that SBs undergo merging, consistent with an FR picture of these structures. The role of FR merging in controlling the structure of SBs in the solar wind is explored through direct observations, analytic analysis, and numerical simulations. Analytic analysis reveals key features of the structure of FRs and their scaling with heliocentric distance R, which are consistent with observations and demonstrate the critical role of merging in controlling the structure of SBs. FR merging is shown to energetically favor reductions in the strength of the wrapping magnetic field and the elongation of SBs. A further consequence is the resulting dominance of the axial magnetic field within SBs that leads to the observed characteristic sharp rotation of the magnetic field into the axial direction at the SB boundary. Finally, the radial scaling of the SB area in the FR model suggests that the observational probability of SB identification should be insensitive to R, which is consistent with the most recent statistical analysis of SB observations from PSP.


Previous studies of literary tourism have investigated visitor perceptions and responses to literary heritage, concluding that literary attractions and landscapes attract both the generalist heritage visitor and a niche segment of highly motivated 'literary pilgrims'. Volunteers are increasingly significant within the heritage sector and this paper draws on research with managers and volunteer staff at a sample of literary heritage attractions in the UK. Although the literary properties and figures play a minimal role in the motivations of volunteers, many derive significant rewards from the literary aspects of the sites. In parallel with literary pilgrims, for a core of literary enthusiast volunteers, the literary figure is the primary motivation and reward. Copyright © 2003 John Wiley & Sons, Ltd.


The schizophylline millipede Ommatoiulus moreleti (Lucas) and the cylindroiuline millipede Cylindroiulus pyrenaicus (Brölemann) (Julida: Julidae) are recorded new for the UK from a site near Bridgend, Glamorganshire, in April 2017. An unidentified millipede first collected in April 2004 from Kenfig Burrows, Glamorganshire, is also confirmed as being C. pyrenaicus. Both species are described and illustrated, enabling identification. C. pyrenaicus is reported as a new host for the Laboulbeniales fungus Rickia laboulbenioides. Summary information is provided on habitat preferences of both species in South Wales and on their foreign distribution and habitats. It is considered likely that both species have been unintentionally introduced into the UK as a consequence of industrial activity in the Valleys of south Wales.


A novel precursor system for metalorganic vapor phase epitaxy of indium‐containing layers, solid trimethylindium (TMI) partly dissolved in N, N‐dimethyldodecylamine, is described. Used in a conventional bubbler, the output concentration of TMI entrained by H2 carrier gas from this source was measured using an ultrasonic cell (Epison) and compared with that from a conventional TMI source. Initially the output stability from both sources was found to be virtually identical; after approximately 50% depletion the output from the solution source was substantially more stable. The solution source was used to deposit InP and lattice‐matched InGaAs/InP, with excellent optical and electrical properties (μ77=181 000 and 44 000 cm2/V s, respectively). With only 5 g solid TMI remaining, the continued stability of the solution source was shown by growing a lattice‐matched GaInAs/InP layer having an x‐ray diffraction peak of 26 arcsec.


Through legal documents from the Monastery of Carrizo and the Monastery of Sahagun, written in the 13th century, we offer some information about the alternantion of the diphthongs ie~ia, coming from E and others origins, in diferent words. The selected century is crucial to attest this type of change in the language spoken in the Kingdom of Leon, as well as the two places that we have analyzed: in the western part, Carrizo, far from the Pilgrims' Route to Santiago de Compostela; in the
eastern part, Sahagun, in the Route.


We examine the collapse of Landau levels in graphene under uniform uniaxial strain and in the presence of a pair of crossed homogeneous electric and magnetic fields. In particular, we obtain the Landau levels and examine their dependence on the strain ϵ . It is shown that the Landau levels collapse when the magnitude of the electric field E reaches a critical value Ec whose magnitude can be increased (decreased) by applying the strain in the zigzag (armchair) direction. We also examine the phenomena in the presence of crossed inhomogeneous fields.


We delineate the important role of 2D conjugated alkylthiophene side chains of polymers in manipulating the molecular orientation and ordering at the polymer donor/polymer acceptor (PD/PA) interface as well as the composition variations in the blend active layer of all-polymer solar cells (all-PSCs). To systematically investigate the impact of 2D conjugated side chains on the performance of all-PSCs, we synthesized a series of poly(benzo[1,2-b:4,5-b]-dithiophene-thieno[3,4-c]pyrrole-4,6-dione) (PBDTTPD) polymer donors with different contents of alkoxy and alkylthiophene side chains, from 0 to 100% (PBDT-TPD (P1, 100% alkoxy side chain), PBDTT0.29-TPD (P2), PBDTT0.59-TPD (P3), PBDTT0.76-TPD (P4), and PBDTT-TPD (P5, 100% alkylthiophene side chain). The P1–P5 polymer donors produced similar PCEs of ∼6% in fullerene-based PSCs. In contrast, for the all-PSC systems, the changes in the side chain composition of the polymers induced a strong increasing trend in the power conversion efficiencies (PCEs), from 2.8...


During sporulation, Clostridium botulinum 33A developed resistance to ultraviolet and gamma rays about 2 hr prior to its development of heat resistance. During germination, loss of resistance to heat, ultraviolet radiation, and gamma radiation occurred essentially simultaneously.


Geary (Biometrika 34, 1947) has introduced a differential series for the density function of Student's t under nonnormality where the sample population is assumed to have finite moments up to a certain order. If (K/sub r/) and (K'/sub r/) are the cumulants of t under the two regimes (normality and nonnormality), then the discrepancies (K/sub r/--K'/sub r/) can be ordered with respect to sample size, in an ordering in powers of 1/..sqrt..n(n = sample size) of the modified density and cumulative distribution function of t. Geary carried this out to order n/sup -2/. Relative error contours comparing Geary's n/sup -1/ and n/sup -2/ approximations of the upper and lower modified probability levels for ..cap alpha.. = 0.05 and n = 15, 20, and 25 are given for sets of mixtures of normal distributions, and Pearson distributions, in the (..sqrt beta../sub 1/,..beta../sub 2/) plane. Additional comparisons are given comparing these approximations from the results of a Monte Carlo simulation for a wide range of mixtures of normal distributions. 2 figures, 2 tables. (RWR)


As a simple and effective tool of information integration, mind mapping can facilitate students' epistemic efficiency and improve teachers' pedagogical content knowledge, which can solve the problems being encountered in the reform of Chinese universities. To establish a systematic instructional method for mind mapping, this paper proposed a new instructional mode based on mind mapping and developed instructional mapping (IM), a classroom teaching software based on the starC system. The starC system is a cloud learning platform, which integrates learning resource, intelligent management, online community, and third‐party service. The starC system has been in use in 16 smart classrooms of Central China Normal University since 2017. However, it seems that many teachers prefer traditional instructional modes than IM. To determine the factors that can encourage teachers to accept IM, we carried out an empirical study based on the technology acceptance model (TAM). The external variables were school factors and student factors. School factors included evaluation and incentive systems. Student factors included students' interest in IM and their evaluation of teachers' use of IM. The empirical study was validated using survey data from 110 teachers. The findings in the TAM analysis revealed significant evidence in favor of the adoption of IM and provided theoretical and practical implications for teachers, school administrators, and instructional mode researchers and developers.


Under the conditions of industrial hot extrusion of aluminium we used an improved method of temperature measurement on the bearing surface of the die and assessed the heat transfer coefficient from the extruded profile on the die bearing surface. The measurements were carried out by means of a split die on the interface of which channels were made for the embedding and welding of thermocouples close to the die-bearing surface. Measurements were carried out for the case of nitrogen cooling of the die and for the case of non-cooling. The extrusion speed was increased up to the melting point of Mg2Si (eutectic phase) with a known melting temperature on the extruding profile surface. Such controlled temperature conditions in the contact "die bearing surface – extruded profile surface" enabled the assessment of the heat transfer coefficient. The latter was found to be an order of magnitude higher (189 kW/Km²) than data known until now in the literature (8–25 kW/Km²).


Authors should provide a brief abstract. References: American Medical Association style. See the following examples: 1. Jones J. Necrotizing Candida esophagitis. J A M A . 1980;244:2190-2191. 2. Stryer L. B i o c h e m i s t r y 2nd ed. San Francisco, Calif: WH Freeman Co; 1980:559-596. Copyright: Materials are accepted for exclusive publication in C N S S p e c t r u m s and become the property of C N S S p e c t r u m s. Permission to reproduce material must be obtained from the publisher. Disclosure of Commercial Interests The authors must include a statement about all forms of support, including grant and drug company support. Such information may, at the editor's discretion, be shared with reviewers. If the article is accepted for publication, the editors will consult with the MedWorks Media Directory of Services GUIDE TO DSM-IV AND ICD-10 CODES DSM-IV ICD-10 Dementia of the Alzheimer Type, With Early Onset With Depressed Mood Specify if: With Behavioral Disturbance Dementia of the Alzheimer's Type, With Late Onset With Depressed Mood Specify if: With Behavioral Disturbance Delirium Due to: Indicate General Medical Condition Psychotic Disorder Due to: Indicate General Medical Condition With Delusions With Hallucinations Mood Disorder Due to: Indicate General Medical Condition Anxiety Disorder Due to: Indicate General Medical Condition Amnestic Disorder Due to: Indicate General Medical Condition Dementia NOS Amnestic Disorder NOS Schizophrenia Schizophrenia—Disorganized Type Schizophrenia—Catatonic Type Schizophrenia—Paranoid Type Schizophrenia—Residual Type Schizoaffective Disorder Schizophrenia—Undifferentiated Type Maior Depressive Disorder Bipolar 1 Disorder Bipolar Disorder NOS Bipolar II Disorder Mood Disorder NOS Psychotic Disorder NOS Autistic Disorder Asperger's Disorder Pervasive Developmental Disorder NOS Anxiety Disorder NOS Panic Disorder Without Agoraphobia Generalized Anxiety Disorder Dissociative Identity Disorder Dissociative Disorder NOS Factitious Disorder NOS Panic Disorder With Agoraphobia Agoraphobia Without History of Panic Disorder Social Phobia Specific Phobia Obsessive-Compulsive Disorder Dysthymic Disorder Depersonalization Disorder Body Dysmorphic Disorder Somatization Disorder Somatoform Disorder NOS Cyclothymic Disorder Alcohol Dependence Cocaine Dependence Cannabis Dependence Amphetamine Dependence Alcohol Abuse Cannabis Abuse Cocaine Abuse Amphetamine Abuse Stuttering Anorexia Nervosa Tic Disorder NOS Tourette Disorder Primary Insomnia Primary Hypersomnia Sleepwalking Disorder Dyssomnia NOS Nightmare Disorder Parasomnia NOS Eating Disorder NOS Bulimia Nervosa Feeding Disorders of Infancy or Early Childhood Communication Disorder NOS Posttraumatic Stress Disorder Depressive Disorder NOS Impulse-Control Disorder NOS Pathological Gambling Pyromania Kleptomania Trichotillomania Disruptive Behavior Disorder NOS Attention-Deficit/Hyperactivity Disorder, Combined Type Attention-Deficit/Hyperactivity Disorder NOS Learning Disorder NOS Developmental Coordination Disorder Narcolepsy Sleep Disorder Due to: Indicate General Medical Condition 290.13 290.21 293.0 293.81 293.82 293.83 293.89 294.0 294.8 294.8 295 295.10 295.20 295.30 295.60 295.70 295.90 296 296 296.80 296.89 296.90 298.9 299.00 299.80 299.80 300.00 300.01 300.02 300.14 300.15 300.19 300.21 300.22 300.23 300.29 300.3 300.4 300.6 300.7 300.81 300.81 301.13 303.90 304.20 304.30 304.40 305.00 305.20 305.60 305.70 307.0 307.1 307.20 307.23 307.42 307.44 307.46 307.47 307.47 307.47 307.50 307.51 307.59 307.9 309.81 311 312.30 312.31 312.33 312.34 312.39 312.9 314.01 314.9 315.9 315.4 347 780 F00.03 F00.13 F05.0 F06.2 F06.0 F06 F06.4 FO2.8 F03 R41.3 F20 F20.1 F20.2 F20.0 F20.5 F25 F20.3 F32 F30 F39 F31.8 F39 F29 F84 F84.5 F84.9 F41.9 F41 F41.1 F44.81 F44.9 F68.1 F40.01 F40 F40.1 F40.2 F42.8 F34.1 F48.1 F45.2 F45. F45.9 F34 F10.2 F14.2 F12.2 F15.2 F10.1 F12.1 F14.1 F15.1 F98.5 F50 F95.9 F95.2 F51.0 F51.1 F51.3 F51.9 F51.5 F51.8 F50.9 F50.2 F98.2 F80.9 F43.1 F32.9 F63.9 F63.0 F63.1 F63.2 F63.3 F91.9 F90 F90.9 F81.9 F82 G47.4 G47 Delirium NOS 780.09 F05.9 MedWorks Media Directory of Services CNS SPECTRUMS* The International Journal of Neuropsychiatric Medicine


57-141547 9/1982 Japan ................................ 252/62.52 833267 4/1960 United Kingdom ............. 252/62.52 Primary Examiner-John P. Sheehan Attorney, Agent, or Firm-Curtis, Morris & Safford (57) ABSTRACT A method of preparing a fluorescent magnetic composi tion useful in non-destructing testing of metal work pieces. The method of the invention utilizes a plasticizer in order to effect a more complete encapsulation of fluorescent pigment and magnetic particle powder by film-forming resin. The invention also provides for the composition made by the inventive method, as well as for the method of using the composition in non-destruc tive testing of magnetizable work pieces.


Since a major concern in the design of pumping station water intakes is the possibility of damage by fish drawn into the facility, some kind of screening system must be installed to minimize or eliminate this possibility. The potentially adverse impact of water intakes is resolved by the implementation of physical screens, which exclude all debris, including fish. The germane difficulties of screens, i.e., the necessity of lowering the approach velocity, poor velocity distribution across the screen, and danger to fish are overcome by the installation of a perforated-pipe inlet with an added internal perforated sleeve. The benefits of such a device, i.e., relative ease of maintenance, uniform approach velocity, uniform inflow, and protection for fish, cannot be equalled by ordinary means of physical screening. For water intakes up to 100,000 gal/min, the inner sleeve type of perforated-pipe intake provides a viable solution to the problem of screening.


Abstract Investigations of light sensitivity and its physiological effects on insects developing within subcortical tree tissues are limited, presumably due to the assumption that cryptic microhabitats are completely devoid of light. In this study, we documented light-mediated behaviour and opsin gene expression in larvae of the mountain pine beetle, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae: Scolytinae), an extremely important forest insect that is well adapted for development beneath the bark of pine (Pinus Linnaeus; Pinaceae) trees and is eyeless in the larval stage. Larvae were negatively phototactic, as they selected dark over light microhabitats in phototaxis assays. We recovered long-wavelength opsin transcripts from all life stages, including eggs and larvae, suggesting that D. ponderosae is photosensitive throughout its entire life cycle. Our results imply that photosensitivity contributes to immature D. ponderosae survival and that extraocular photoreception could be common among bark beetle larvae.


This paper presents a new approach for optimizing communication of data parallel programs. Our techniques are based on unidirectional bit-vector data flow analyses that enable vectorizing, coalescing and aggregating communication, and overlapping communication with computation both within and across loop nests. Previous techniques are based on fixed communication optimization strategies whose quality is very sensitive to changes of machine and problem sizes. Our algorithm is novel in that we carefully examine tradeoffs between enhancing communication latency hiding and reducing the number and volume of messages by systematically evaluating a reasonable set of promising communication placements for a given program covering several (possibly conflicting) communication guiding profit motives. We useP3T, a state-of-the-art performance estimator, to ensure communication buffer safety and to find the best communication placement of all created ones. First results show that our method implies a significant reduction in communication costs and demonstrate the effectiveness of this analysis in improving the performance of programs.


There are a number of Library and Information Science (LIS) journals available worldwide on the various aspects of library and information science. However, there is no journal exclusively on library marketing although a significant number of LIS journals cover articles on marketing. Many LIS journals have also brought out special issues on marketing and related aspects from time to time. Such journals that have brought out special issues in the past includes, Catholic Library World, Library Journal, Illinois Libraries, Journal of Library Administration, ASLIB Information, Library Trends, Computers in Libraries, Kirjastolehti, NLA Quarterly, Information Outlook, PNLA Quarterly, SCONUL Focus, DESIDOC Bulletin of Information Technology, Acquisition Librarians, Information and Library Manager, College and Undergraduate Libraries, EBIB Bulletin, Mississippi Libraries, Colorado Libraries, etc,.


Objective:To investigate the correlationship between children intraocular pressure(IOP) and ametropia.Methods:Totally 254 children ( 508 eyes) were mearsured with non-contact tonometer in fixed time. Retinoscopy were used to measure refractive status. Hyperopic ,middle-low myopic and high myopic groups were divided by their refractive values. Results:The mean IOP values of the three groups were 15.4±2.7 mmHg(hyperopic group),16.2±3.0 mmHg (middle-low myopic group) and 18.8±2.6 mmHg(high myopic group). There was significant difference in the TOP among them(P0.05)and the IOP showed a increasing trend with refractive values(r=0.313,P0.05). Conclusion:There is a certain positive correlation between IOP and refractive values in children.We should pay more attension to the IOP values in myopia children.


The alignment of vorticity and gradients of conserved and reactive scalars with the eigenvectors of the strain rate tensor (i.e., the principal strains) is investigated in a direct numerical simulation of a turbulent nonpremixed flame achieving a Taylor's scale Reynolds number in the range 100≤ Reλ ≤ 150 (Attili et al. Comb. Flame, 161, 2014 ). The vorticity vector displays a pronounced tendency to align with the direction of the intermediate strain. These alignment statistics are in almost perfect agreement with those in homogeneous isotropic turbulence (Ashurstet al. Physics of Fluids 30, 1987 ) and differ significantly from the results obtained in other nonpremixed flames in which vorticity alignment with the most extensive strain was observed (Boratavet al. Physics of Fluids 8, 1996 ). The gradients of conserved and reactive scalars align with the most compressive strain. It is worth noting that conditioning on the local values of the mixture fraction, or equivalently conditioning on the distance from the flame sheet, does not affect the statistics. Our results suggest that turbulence overshadows the effects of heat release and chemical reactions. This may be due to the larger Reynolds number achieved in the present study compared to that in previous works.


Acute hepatic injury model was induced by CCl4 in mice to study the protective effect of exo-polysaccharides produced by Grifola frondosa(GFP)on experimental liver injury in mice.The activities of alanine aminotransfe(ALT),aspartate aminotransferase(AST),catalase(CAT) in serum,lactate dehydrogenase(LDH),and the content of maleic dialdehyde(MDA) in the liver tissue were investigated,and the histological changes of liver were observed.GFP could decrease the serum activities of ALT,AST,and the activity of LDH,MDA content in liver tissue,but increase the serum activities of CAT of mice with acute hepatic injury induced by CCl4,and it could lessen the histological changes of liver.Consequently,we can see clearly that GFP showed protective effect on mice with acute hepatic injury.


Objective : to determine the efficacy of 2 oxaliplatin-based chemotherapy regimens (FOLFOX and XELOX) for metastatic colorectal cancer (CRC) depending on the KRAS mutation status and primary tumor location. Materials and methods . We performed retrospective analysis of the data on patients with metastatic CRC taken from a prospective database. We included patients with known KRAS mutation status that received either FOLFOX or XELOX without targeted drugs. Progression-free survival (PFS) was used as a main criterion in estimating treatment efficacy. Results . The inclusion criteria were met by 157 patients. The FOLFOX regimen was more effective in patients with wild-type KRAS CRC: median PFS was 10 months versus 8 months in the XELOX group (hazard ratio (HR) = 0.7; 95 % confidence interval (CI) 0.4–1.2; р = 0.1). However, we observed no significant differences in median life expectancy between these groups: it was 37 and 38 months respectively (HR = 1.1; 95 % CI 0.6–2.1; p = 0.6). Similar trends were observed in patients bearing KRAS mutations: median PFS in the FOLFOX group was 9 months vs 5 months in the XELOX group (HR = 0.6; 95 % CI 0.3–1.2; р = 0.1; p value by Breslow – Day test = 0.04). No differences in median life expectancy between these groups were observed: 33 and 23 months respectively (HR = 0.8; 95 % CI 0.4–1.6; p = 0.5). Conclusion . We failed to find an association between the KRAS mutation status and response to a particular chemotherapy regimen. We found that patients with metastatic CRC receiving the FOLFOX regimen were more likely to achieve objective responses and demonstrated higher median PFS than patients on the XELOX regimen.


Complete Lyapunov functions for a dynamical system, given by an autonomous ordinary differential equation, are scalar-valued functions that are strictly decreasing along orbits outside the chain-recurrent set. In this paper we show that we can prescribe the (negative) values of the derivative along orbits in any compact set, which is contained in the complement of the chain-recurrent set. Further, the complete Lyapunov function is as smooth as the vector field defining the dynamics. This delivers a theoretical foundation for numerical methods to construct complete Lyapunov functions and renders them accessible for further theoretical analysis and development.


Twenty measurements of heat flow in the Caribbean Sea, the North Atlantic Ocean, and the Mediterranean Sea are described and compared with nearby measurements made by others. Heat-flow measurements in the Caribbean gave values which average about 1.2 to 1.4 μcal/cm2 sec. East of the Antilles the value found may not be equilibrium heat flow because of past disturbance of the sediment. Values as low as 0.3 μcal/cm2 sec were found on the flanks of the mid-Atlantic ridge, and values as high as 6.5 μcal/cm2 sec were found at the crest. In the eastern Atlantic, normal values of about 1.2 μcal/cm2 sec were found. In general, the agreement between measurements made by independent investigators and different instruments is good. In the North and South Atlantic, values exceeding 2.5μcal/cm2 sec are found only within 100 km of the crest of the mid-Atlantic ridge. The average of 32 measurements within 100 km of the ridge crest from about 30°S to 50°N is 3 μcal/cm2 sec (twice the world average), indicating that the outflow of heat per centimeter of length from the 200-km-wide crestal region is about 2 or 3×109 cal/cm year. Possible causes of the high crestal heat flow are quantitatively evaluated.


Abstract The concluded results of an experimental study are reported, confirming that the absorption of vitamin B12 takes place in two ways: 1. through the mediation of intrinsic factor; 2. without mediation of intrinsic factor.

The former mechanism allows a B12 absorption in normally IF-sensitive cases of pernicious anemia and in normal persons with an upper limit of about 2 μg. The latter mechanism allows an absorption of vitamin B12 which is roughly proportional to the oral dose administered, and amounts to about 1.2% of the dose, within a very wide dose range. Thus, it is possible to increase the uptake to any desired level. This direct uptake was found to be of the same magnitude, irrespective of whether the patient had a normal absorption, was suffering from pernicious anemia with or without resistance to intrinsic factor preparations, or had some other form of disturbed B12 absorption (idiopathic malabsorption, postoperative state after extensive gastric or intestinal resections, or ileitis). The result of a long-term clinical trial is also reported, in which a daily oral dose of 500–1000 μg of vitamin B12 without intrinsic factor was given to patients with pernicious anemia and other types of vitamin B12 deficiency. The material comprised 64 patients followed for up to more than 5 years. After the remission period very few serum B12 determinations showed borderline or subnormal values, and low levels were never of long duration. At the conclusion of the study the serum B12 values were well within the normal range in all cases. Also the individual mean values of the B12 determinations, made during the observation period from the second month of treatment, were normal in all cases. No neurological complications were observed. The blood values were normal in all but a few cases, in which concurrent diseases were present (malignancy, chronic infections, iron deficiency states). Experimental evidence obtained indicates that oral treatment with 500 μg of B12 daily has also resulted in replenishment of the B12 depots. The treatment with high oral doses of vitamin B12 thus constitutes a convenient and completely reliable maintenance therapy in pernicious anemia and other states of B12 deficiency, and is a fully acceptable alternative to the conventional method of vitamin B12 injections. This type of therapy (1000 μg B12 daily) was introduced into Sweden in 1964 and is now extensively used.


One of the most important environmental problems of the last decade is water (groundwater, surface wat er) contamination, which poses a significant ecological risk to the environm e t and human health. Permeable reactive barrier (P RB) is an efficient technology for remediating contaminated water on industrial and mi ning sites. The PRB technology is based on an empla cement of a reactive material in the subsurface designed to intercept a contaminated groundwater plume. The contaminated plume flows th rough the reactive material where the contaminants are transformed into environmental ly cceptable species. The aim of the present study was to test experimentally caustic calcined magnesia, limestone, dolomite and blast fu rnace slag as potential reactive materials for the PRB technology. The effects of the chemical composition of contaminated water and wate r-to-reactive material weight ratio on the efficien cy of heavy metals removal were investigated. The results have shown that caustic c al ined magnesite (CCM-KK) was the most suitable re active material for removal of cations Fe3+, Al3+, Cu2+, Zn2+, Ni2+, and Mn2+. Thi s reactive material was able to increase the pH of the contaminated water to the value of about 10 and the efficiency of selected ca tions removal up to 100 % was observed.


There are many reasons for digitising your records. One is to preserve them better, especially when they have already become fragile, and another is space saving. Digital records can also be shared very easily, and they can be copied, printed and displayed very readily. They can also be integrated into the church's current administration system where everything else is already digital. (This paper does not cover the archival handling of existing digital records.)


Summary The State forests of New South Wales (NSW) are a very important resource for the NSW beekeeping industry. In 1995/96, 3749 occupation permits were issued for bee fanning, and this number increased to 3843 in 1997. On average, 100–120 beehives were periodically placed on each occupation permit site, the number and location being determined by the flowering of species which beekeepers regarded as reliable producers of nectar and pollen. Commercial apiaries were also periodically placed adjacent to State forests, allowing the bees to fly to the floral resources of these forests. The fraction of sites located on private property in this way varied from 5% to 57%, depending on the forestry district, with an average of 34%. Thus the actual number of commercial honey bees accessing the State forest floral resources was much higher than occupation permits indicated. The main floral species of importance for beekeeping within the NSW coastal forests were Banksia ericifolia, Corymbia maculata, C. variegata, Eucalyptus muelleriana, E paniculata, E. sidemphloia, Lophostemon confertus, E. acmenoides and E. longifolia. The ironbark group of eucalypts was a major source of nectar for honey bees throughout the State forests of NSW. The main tablelands species were E. viminalis and E. pauciflora, although as there are fewer forest districts on the tablelands the frequency of mention across more than one forest district was reduced. The species of importance in the western forests included C. trachyphloia, E. camaldulensis, E. crebra, E. largiflorens, E. microcarpa, E. sideroxylon and E. fibrosa. This paper provides a collective anecdote of the most important nectar—and pollen-producing flora of value to commercial beekeepers within the forests under the management of Forests NSW.


The Sam Adams of C. Michael Hiam's book is neither the hero of the American Revolution nor the beer, but Samuel A. Adams (1933–88), who in his 10-year career as a CIA analyst caused more trouble than any analyst before or since. Sam, a distant relative of his 18th-century namesake, arrived at the Agency in 1963 after a brief spell as a "downwardly mobile WASP" (his term) in the outside world. By his own account, Sam's bosses were calling him "the outstanding analyst" in the Agency after he had been there only three years.1 In another three years, they were badgering him to resign. His story raises important questions about the relationship between intelligence and policy that persist to this day.


Groundwater data (161 samples) show that an area encompassing groundwater samples with >= 6.45 ppB U is present in the central portion of the study area. These samples are produced primarily from the Valley Springs Gneiss, Town Mountain Granite, and younger granites. High specific conductance values do not correlate strongly with high U values, indicating that U in groundwater is not a function of dissolved solids. Li, Si, K, Na, Cl, and SO/sub 4/ correlate positively with U, while total alkalinity, pH, and bicarbonate correlate negatively with U. The uranium:specific conductance, U:B, and U:SO/sub 4/ ratios correlate positively with U. Groundwater data indicate the presence of U in a slightly acidic, low salinity hydrogeochemical environment. Stream sediment data (651 samples) indicate that four areas with soluble U values >= 4.13 ppM are present in the central, northwestern, and eastern portions of the survey area. All of these areas are associated with the presence of Precambrian granites. Areas with high total U (U-NT) values are generally coincident with high soluble U trends. Though trace element associations vary for each of the four areas, all are high in Ce, La, Y, and Zr. Soluble U is positively correlated with Y, Zr, Be,more » Ce, La, Fe, Na, Ba, Ti, Mn, Li, Zn, Pb, Th, Nb, Sc, and V; and it is negatively correlated with Ca, Se, Mg, and B. Th values >= 17 ppM coincide with high U values in three of the four aforementioned areas. Th correlates positively with soluble and total U, the Th/total U ratio, Y, Zr, Be, Ce, La, Na, Ag, and Nb, and negatively with Ca and Mg. A polymetallic association including Cr, Co, Cu, Fe, Ni, Sc, V, and Zn is present in sediment derived from some portions of the Precambrian Llano Supergroup.« less


Osteonecrosis of the femoral head (ONFH) often affects young active adults and leads to destruction of the hip joint and disabling arthritis. Several procedures have been developed to arrest the progress of osteonecrosis and postpone the procedure of total hip replacement especially in young patients. The aim of this multicenter study was to analyze the results of the use of the vascularized iliac bone flap transfer for management of ONFH.


The characteristic properties exhibited by plastics are the direct result of the unique molecular structure of these materials. Taking that a step further, the variation within the properties demonstrated by different plastics arises from diversity in their structure. Plastics are polymers of very high molecular mass. To enhance their properties, they often contain additives, such as fillers and reinforcements, anti-degradants and stabilizers, flame retardants and plasticizers. However, the underlying attributes of a plastic material are determined by the polymer.


The present study has a dual aim of supporting magnetic nanoparticles over the nanolayers of LDHs and designing two-dimensional magnetic nano-nets of cobalt ferrite. In this trend, nanoparticles of CoFe2O4 were prepared and supported by Co-Fe LDH through urea hydrolysis. The nanolayered structures of Co-Fe LDH were confirmed by X-ray diffraction, energy-dispersive X-ray spectrometry, FT-IR spectra, thermal analyses, and transmission electron microscopy. In addition, they indicated that 13.2% CoFe2O4 were supported over Co-Fe LDH. Transformation of the nanolayered structures of Co-Fe LDH to nano-nets was achieved by the catalytic effect of the supported CoFe2O4 nanoparticles through solvent thermal technique. X-ray diffraction patterns and transmission electron microscopy images confirmed the transformation of the supported Co-Fe LDH to nano-nets of cobalt ferrite. In order to indicate the effect of the LDH for designing the nano-nets, nanoparticles of cobalt ferrite were prepared by the same technique without LDH. The magnetic behavior of the nano-nets and the supported Co-Fe LDH were measured and compared with the nanoparticles through vibrating sample magnetometer technique. The magnetic parameters indicated that the prepared nano-nets have ferromagnetic behavior and high coercivity. However, the prepared nanoparticles revealed a superparamagnetic state and low coercivity. The experimental results concluded that the incorporation of nanoparticles with nanowires into nano-net structures has been found to be an efficient way to improve their magnetic properties and prevent their agglomerations. Finally, layered double hydroxides are an important source for constructing magnetic nanolayered structures and nano-nets.


Objective: To evaluate the postprandial glucose response of dates and white bread (25g) in diabetics and non-diabetics.
Methodology: It was cross-over/cross observational study done at Shifa International Hospital in May-October 2016. The study subjects were adults with Type 2 diabetes mellitus (DM) of age more than 30 years and the healthy controls. Each group was administered equally weighed (25 g) dates and white bread for two days with one week apart. Post prandial blood glucose measurements for dates and white bread was done in both groups and compared by applying student's t-test.
Results: Each group had twelve participants. The mean blood glucose response for both food groups was significantly higher in diabetics than controls. The peak response for dates in both groups was at 30 minutes and the peak response for bread was 60 and 30 minutes in diabetics and controls respectively. Response of dates and bread in diabetics was not statistically significant. The mean fasting glucose in diabetics and non -diabetics was 131.04 mg/dl and 90.12 mg/dl respectively.
Conclusion: Dates are suitable for diabetics and their consumption bears no added risk or danger over white bread.


Intracellular recordings of magnocellular neurons from the supraoptic nucleus of guinea‐pigs were made with KCI/K citrate‐ and biocytin‐filled electrodes. Fifty of 99 cells exhibited a time‐dependent inward rectification (TDR). The TDR was activated during hyperpolarizing current pulses to membrane potentials more hyperpolarized than −75 mV. In voltage‐clamp recordings, an inward current appeared at voltage steps more hyperpolarized than −75 mV, with properties similar to the slow inward rectifier (Ih) described in other tissues. The Ih was blocked by 2 mM CsCI. BaCI2 (100 to 500 μM) did not block the Ih. Immunocytochemical identification of the recorded cells revealed that both vasopressin (AVP)‐ and oxytocin (OT)‐ containing neurons exhibited an Ih.


With the rapid development of internet technology,the multimedia teaching system adopting the streaming media technology plays an important role in the Teaching because of its convenience,advancement and integration.The streaming media courseware provided by the System and transmitted to the client end and used by the students can excite the interest of the students in learning and improving the teaching quality completely.


In numerical simulation domain, more complex physics are getting involved to explain real phenomena in engineering activities due to acceptable computing powers and stable efforts among seeking labors for multiphysics. Even though several commercial software companies have released their own methodologies for Fluid Structural Interaction problems, the successful application results are not as many as expected. In this study, the reasons of rare cases in real Fluid Structural Interaction applications and some important coupling configurations are investigated. The problems are based on the publication and various parameters for different governing equations are adopted to provide the general insights for engineers who need FSI analysis capabilities especially in partitioned approaches. The main scope in this paper is the tight two way coupling scheme for Computational Fluid Dynamics and Computational Structural Mechanics for better convergence with minimized calculation errors in shorter computing time. Among various commercial solutions for interaction analysis, the results are studied between STAR-CCM+ V6.06 and ABAQUS 6.11 to realize parametric effects on variants in numerical results and convergence problems through coupling scheme itself.


High frequency fluctuation in the optical signal generated in Fourier-Domain Mode Locked fiber laser (FDML-FL), which is the major problem and degrades the laser performance, is not yet fully analyzed or studied. The basic theory which is causing this high frequency fluctuation is required to clearly understand its dynamics and to control it for various applications. In this letter, by analyzing the signal and system dynamics of FDML-FL, we theoretically demonstrate that the high frequency fluctuation is induced by the intrinsic instability of frequency offset of the signal in cavity with nonlinear gain and spectral filter. Unlike the instabilities observed in other laser cavities this instability is very unique to FDML-FL as the central frequency of the optical signal continuously shifts away from the center frequency of the filter due to the effects like dispersion and/or nonlinearity. This instability is none other than the Eckhaus instability reported and well studied in fluid dynamics governed by real Ginzburg-Landau equation.


GH, in the presence of glucocorticoid, produces a delayed increase in lipolysis in rat adipose tissue, but the biochemical mechanisms that account for this action have not been established. Other lipolytic agents rapidly activate adenylyl cyclase (AC) and the resulting production of cAMP initiates a chain of reactions that culminates in the activation of hormone-sensitive lipase. We compared responses of segments of rat epididymal fat or isolated adipocytes to 30 ng/ml GH and 0.1 μg/ml dexamethasone (Dex) with 0.1 ng/ml isoproterenol (ISO), which evoked a similar increase in lipolysis. All measurements were made during the fourth hour after the addition of GH+Dex or immediately after the addition of ISO to cells or tissues that had been preincubated for 3 h without hormone. Although no significant increases in cAMP were discernible in homogenates of GH+Dex-treated tissues, RP-cAMPS (RP-adenosine 3′5′-phosphothioate), a competitive inhibitor of cAMP, was equally effective in decreasing lipolysis induced by...


In view of the interference fringe figure when fabricating air membrance is zero in Michelson Interferometer. The paper explains, theoretically, the reason of interference fringe figure and draws a conclusion from it.


The equivalent method of the relative movement goods on board is discussed in details. This method is to establish dynamic model based on moving trajectory of gravity-center for goods and to take rigid body geometric model with the trajectory as constraints in ADAMS. The difference of simulation methods for the different goods in carrier rolling is compared. The interact of relative moving objects with bulk carrier is discussed by using the ADAMS model. It is verified that the ballast water can maintain the ship's stability by means of the ADAMS model.


The heuristic evaluation (HE) of differential strategies (DS) for the dissipation of dysfunctional cognitive and affective psychopathology (DODCAAP) has been addressed with ongoing evaluative modalities (OEM) for many years without an emergent consensus concerning their meaningful effective roles (MER). Their strategic perspectives (SP) have been addressed in this study, and the attention deployment(AD), reactive vigilance (RV), process withdrawal reactivity (PWR) and other ongoing responses to two strategic modalities of intervention are addressed with investigational techniques (IT).


. The article analyzes the current state of information technologies and software products used for automated accounting. It is noted in the work that the use of accounting programs at the enterprise provides ample opportunities for timely display of any economic transactions and documents in accounting. It has been proven that software products such as 1C: Enterprise are in the greatest demand among accounting programs in Ukraine. 8.3 and programs of the BAS line. These programs have many common characteristics aimed at


The combination between the flying wing morphing concept and the use of modern command and control system offers exponential advantages having a leverage effect in the economy and research. The flying wing architecture has the advantage of low cost against efficiency, the morphing of this concept defining the new characteristic frontiers and aerodynamic performances which derive immediately. On designing an unmanned aerial vehicle for a various range of missions, its lifting surface needs to display optimal geometrical features, so that the UAV may maintain the induced drag and the moment coefficient at reasonable levels. The command and control of the lifting surfaces in morphing concept offer characteristics and in-flight performances at a superior level. The limits of the system depend on the reliability of the execution elements and the grade of accuracy for the control laws which are implemented in the calculation module. The paper aims at presenting an analysis regarding the robotic air systems of flying wing type through the aerodynamic analysis and with the help of specific software instruments. The performances and flight qualities depend directly on the geometry of the lifting surface of the aerial vehicle.


High efficiency video coding (HEVC) has been deemed as the newest video coding standard of the ITU-T Video Coding Experts Group and the ISO/IEC Moving Picture Experts Group. In this research project, in compliance with H.265 standard, the authors focused on improving the performance of encode/decode by optimizing the partition of prediction block in coding unit with the help of supervised machine learning. The authors used Keras library as the main tool to implement the experiments. Key parameters were tuned for the model in the convolution neuron network. The coding tree unit mode decision time produced in the model was compared with that produced in the reference software for HEVC, and it was proven to have improved significantly. The intra-picture prediction mode decision was also investigated with modified model and yielded satisfactory results.


The purpose of this study was to first determine if neuromuscular scoliosis results in greater peri-operative transfusion requirements compared to idiopathic scoliosis, and secondly to compare the effects of tranexamic acid (TXA) dosing on reducing transfusion requirements in scoliosis surgery. Previous studies have suggested that patients with neuromuscular scoliosis tend to have more blood loss during scoliosis corrective surgery as compared to patients with idiopathic scoliosis. Tranexamic acid has not been studied extensively in these populations and consensus regarding appropriate dosing has not yet been elucidated. A retrospective chart review of all patients who underwent posterior instrumentation and fusion for scoliosis for the years 1999 to 2006 was performed. Peri-operative transfusion requirements for idiopathic and neuromuscular scoliosis patients were compared and grouped according to TXA use. Transfusion requirements for those patients receiving either a low (10mg/kg loading, 1mg/kg/h infusion) or high (20mg/kg loading, 10mg/kg/h infusion) dose TXA were also compared. Idiopathic patients had significantly decreased transfusion requirements overall (no TXA: idiopathic 1028.3 ± 558.7ml vs. neuromuscular 1400.7 ± 911.3ml, p = 0.02; with TXA: idiopathic 1082.9 ± 1005.5ml vs. neuromuscular 2043.8 ± 1397.5ml, p = 0.03). In the idiopathic group, high dose TXA resulted in a significant reduction in peri-operative transfusion requirements compared to low dose TXA (687.9 ± 778.1ml vs. 1355.0 ± 965.8ml, p = 0.04). Neuromuscular scoliosis patients have significantly higher transfusion requirements as compared to idiopathic patients. For patients with idiopathic scoliosis, the use of the high dose TXA is suggested over low dose TXA given the relative reduction in transfusion requirements for the high dose group.


Modeling of biological objects on the basis of computer and magnetic resonance imaging is a common practice today. DICOM source files (CT with contrast agent, heart without pathologies) were obtained at the Saratov cardiology center and correspond to diastole of cardiac cycle. The created geometric model consists of the internal volume of blood, ventricles, atria, heart valves and tendon chords. The resulting model can be studied using various computer systems, in particular, the finite element method.


The Ecuadorian educational system has been transformed by the implementation of the National Ten-Year Plan (PDN, for its Spanish title, Plan Decenal Nacional), which was renewed until 2025. This qualitative study examined the self-reported perceptions of 20 private elementary school teachers regarding the Ecuadorian educational system. Study questions addressed (1) participants' perceptions of the educational system using a survey based on the 5Essentials inquiry tool developed by Langley (2009) as an evaluative measure, and (2) challenges educators identified as barriers to learners' academic achievement. Survey validity was evaluated by three Ecuadorian educators from the area where this research was conducted. Data collected from teachers were triangulated utilizing administrators' interviews and an analysis of the school's policies. Study findings suggest that participating teachers felt that they had received insufficient and limited support from school administration and parents, leading to teacher disempowerment.


To determine the optimum proportion of materials used in a mix design to achieve a specified quality with least cost is the most important aspect in the production of concrete. Currently available methods for proportioning aggregates are based mosthly on previous experience. Even their application to the conventional continuously graded concrete is short of being optimum. It has become essential to seek quantitative information for the optimum proportioning of gap-graded and continuously graded aggregates for various significant mix parameters. In the present work involving 200 mixes with tests carried out according to ASTM standard methods, the results have been analyzed with the objective of revealing optimum mix proportions with respect to significant mix parameters, such as size and quantity of coarse aggregate, size and quantity of the fine aggregate, cement content, and water-cement ratio, at pratically the same air content for both gap-graded and continuously graded concretes. The optimum cement contents for both concretes are on the basis of equal mazimum size of coarse aggregate and equal compressive strength. The comparison has shown that much less cement is required for concrete with gap-graded aggregates than its continuously graded counterpart with approximately the same workability. Gap grading of the aggregates results in lower requirement of water content, and hence lower water-cement ratio, and permits a higher aggregate-cement ratio to achieve the same workability as its continuously graded counterpart with equal cement content and equal maximum size of coarse aggregate.


Detecting moving vehicles and people is crucial for safe operation of UGVs but is challenging in cluttered, real world environments. We propose a registration technique that enables objects to be robustly matched and tracked, and hence movers to be detected even in high clutter. Range data are acquired using a 2D scanning Ladar from a moving platform. These are automatically clustered into objects and modeled using a surface density function. A Bhattacharya similarity is optimized to register subsequent views of each object enabling good discrimination and tracking, and hence mover detection.


The paper gives the series expansion for the Koch curve. By this representation, we prove that the Koch curve satisfies Holder condition with exponent a = log3/log4, and nowhere differentiable.


This study empirically explores the role of web traffic in explaining the stock prices of e-tailers. In particular, we hypothesize that the actual buy rate is a key value driver of Internet retailers because it represents the direct performance of these firms in the electronic market place. Our empirical analysis indicates that the buy rate is strongly related to the market value of e-tailers in a positive way after controlling for the roles of such financial valuation measures as net income, revenue, sales and marketing expenses, research and development costs, and book value.


Background:
 Regulatory T (Treg) cells are increasingly implicated as modulators of myocardial ischemia-reperfusion (I/R) injury. We have previously found that extracellular vesicles isolated from human cardiosphere-derived cells (CDC-EVs) could promote Treg proliferation and augment production of the anti-inflammatory cytokine IL-10 in vivo, attenuating cardiac inflammation and functional decline. However, the mechanism by which CDC-EVs regulate Treg is largely unknown. In this study we
 assessed the hypothesis
 that long non-coding RNA (LncRNA) within CDC-EVs induces Treg proliferation, migration and IL-10 production, which mediates cardioprotection.

 Methods:
 BCYRN1 (Brain Cytoplasmic RNA 1) was identified as a LncRNA species in CDC-EVs using RNA sequencing. We assessed CDC-EVs and LncRNA BCYRN1 effects on Treg by measuring cell proliferation (Cell Counting Kit-8 assay), cell migration (trans-well migration assay), and the production of IL-10 (qPCR and ELISA assay). Additionally, RNA pulldown and luciferase assays were used to determine whether BCYRN1 functions as a miRNA sponge.
 In vivo
 , I/R injury was induced in 8-week-old C57BL/6 mouse by left anterior descending coronary artery ligation for 45 minutes followed by reperfusion. Fifteen minutes later, the mice received (i.v., via tail vein) CDC-EVs, CDC-EV BCYRN1 (overexpress BCYRN1 in CDC-EVs), or vehicle (PBS). Infarct size (by TTC staining) and infiltrating Treg (by flow cytometry) were assessed 72 hrs post I/R.

 Results:
 Exposure of human Treg to CDC-EVs resulted in Treg proliferation (3.00± 0.11 fold increase, N=5), migration (1.77 ± 0.10 fold increase, N=5), and production of IL-10 (qPCR: 2.60 ± 0.35 fold increase, N=6 and ELISA: 6.12 ± 0.78 fold increase, N=5). RNA sequencing of CDC-EV contents showed that BCYRN1 was one of the most highly enriched LncRNAs. RNA pulldown and luciferase assays showed that BCYRN1 contained binding sites for multiple miRNAs, including miR-138, miR-150 and miR-98 that repress the expression of ATG7, CCR6 and IL-10 mRNAs, respectively. These results reveal that BCYRN1 serves as a miRNA sponge, leading to Treg cell proliferation (via induction of ATG-7 dependent autophagy), CCR-6 dependent migration and production of IL-10. In the mouse I/R model (N=5, each group), CDC-EVs and CDC-EV BCYRN1 (but not vehicle) induced Treg infiltration, proliferation and IL10 production in the heart, with a concomitant decrease of infarct size.

 Conclusions:
 We have pinpointed BCYRN1 as a bioactive constituent of CDC-EVs, promoting Treg cell-mediated cardioprotection. BCYRN1 serves as a miRNA sponge to mediate its beneficial effects on Treg infiltration, proliferation, and IL-10 production in the heart. Thus, a single LncRNA mimics the effects of CDC-EV on Treg
 in vitro
 and
 in vivo
 . Our study provides a novel approach, targeting Treg by a defined LncRNA mined from CDC-EV, to treat myocardial infarction.


Pre-school brings a wealth of new experiences for young children, but some of these can be less than pleasant, such as an introduction to head lice. Remember, with one in ten children having head lice at any one time it's nothing to be embarrassed or worried about.


The workpiece (1), namely, injection mold or insert for an injection mold or a die-casting mold, comprising an apparatus for early detection of cracks in the workpiece (1), characterized in that in the region of at least one crack-prone surface, at least one acted upon by a test medium under pressure test area (4) is arranged, which is formed by a generative manufacturing method of the workpiece (1) or a workpiece portion, wherein the test area (4) is either a pressure sensor (6) for determining one of a cracking of the workpiece (1) is connected to the resulting pressure drop or in the environment of the test room (4), a gas sensor is disposed, the leakage of a case of crack formation from the test area (4) the test medium is reagierfahig, wherein the test area (4) under a pressure-loaded contour (7) of the workpiece (1) is arranged, wherein the workpiece (1) with a cooling channel structure (8) is provided and of audit fraum (4) at least in regions between the pressure-loaded contour (7) of the workpiece (1) and the cooling channel structure (8).


The Human Visual System appears to be using a low number of sensors for image capturing, and furthermore, regarding the physical dimensions of cones—photoreceptors responsible for the sharp central vision—we may realize that these sensors are of a relatively small size and area. Nonetheless, the human eye is capable of resolving fine details thanks to visual hyperacuity and presents an impressive sensitivity and dynamic range when set against conventional digital cameras of similar characteristics. This article is based on the hypothesis that the human eye may be benefiting from diffraction to improve both image resolution and acquisition process. The developed method involves the introduction of a controlled diffraction pattern at an initial stage that enables the use of a limited number of sensors for capturing the image and makes possible a subsequent post-processing to improve the final image resolution.


particularly the sensitivity and specificity, of the Focus HSV-2 ELISA in Chinese STD settings, 105 serum specimens were collected from patients attending the STD Clinic of the Chinese Academy of Medical Sciences, and the Peking Union Medical College Institute of Dermatology. The results obtained with the Focus HSV-2 ELISA were compared with those determined by the Western blot method. The seroprevalence of HSV-2, as determined by Western blot, was 55.2% (58 ⁄ 105 specimens) in the study population. The Focus HSV-2 ELISA and Western blot results were concordant (both negative or both positive) for 89.5% of the 105 specimens, with 92.0% sensitivity and 95.7% specificity, and positive and negative predictive values of 95.8% and 91.7%, respectively, if specimens with equivocal ELISA results were excluded from the calculation. The sensitivity and specificity were 79.3% and 95.7%, respectively, if the samples with equivocal ELISA results were considered negative, and were 93.1% and 93.6%, respectively, if the samples with equivocal ELISA results were considered positive. Analysis with a receiver operator characteristic curve demonstrated that the best index cut-off value to optimise the assay performance in this population was 0.9, with a sensitivity of 93.1% (95% CI, 83.3–98.0%) and a specificity of 93.6% (95% CI, 82.4–98.6%). If the manufacturer's recommended index cut-off value of 1.1 was used, the sensitivity was only 79.3%. In summary, the sensitivity and specificity of the Focus HSV-2 ELISA in a Chinese STD population were satisfactory but, compared with other countries, a lower index cut-off value might be required for optimal sensitivity and specificity.


Abstract : A time-shared, two-channel magnetic counter and digital-to-analog converter is described. The counter is capable of performing unit addition and subtraction. The design objective - to reduce the number of components - was well satisfied by the use of all-magnetic shift registers as the storage elements. Only two components are required for magnetic storage, whereas ten components were required for transistor flip flop storage. The logic operati formed by time-shared diode gate circuits. The calculated worst-case error for the digital-to analog conversion is or - 0.3%. The measured error is less than or - 0.25%. This error is due to variations in the bulk resistivity of diodes and PNPN switches, and it can be reduced, theoretically, to less than or - 0. 1%.


In this study, we have been constructed measuring system for spill over by the Japan TV broadcasting signals and analyzed those signals using APD curve. In Busan, we have been measured channel of Japan TV broadcasting signals during 9 months. The quality of image is that maximum grade is 2.5 level, and the quality of sound is that maximum grade is 3 level. In the result of analysis for measured Japan TV broadcasting signals, we have been observed Japan TV broadcasting signals those we have been chosen the ch 36 and ch 38, plotted the APD curve of each channel for a season, in Specially.


A large quantity of Satsuma mandarin (3-3.5 million tons) has been produced in Japan and about 20% of it has been processed for juice. Many types of juice extractor, such as the Citrus Master extractor, Reamer extractor, Chopper-pulper extractor and FMCIn-line extractor were developed for Satsuma mandarin fruit extraction, and the In-line juice.extractor is the most widely used amongthem. However, each of those juice extractors has some disad-


The authors recently developed an analytic theory of cumulative multibunch beam breakup that includes a linear variation of transverse focusing across the bunch train. The focusing variation saturates the exponential growth of the beam breakup and establishes an algebraic decay of the transverse bunch displacement versus bunch number. In this paper they illustrate how the focusing variation works to suppress multibunch beam breakup, as well as how the mechanism scales with accelerator and beam parameters.