A novel Bragg fiber grating (FBG) in an embedded-core hollow optical fiber (ECHOF) has been proposed and experimentally demonstrated. The high-quality FBG fabricated with phase-mask technique by using 248 nm ultraviolet laser, has a resonant wavelength of ~943.1 nm and a dip of ~24.2 dB. Subsequently, the dependences of the resonant peak on the temperature and the axial strain were studied. Experimental results show that the temperature and axial stain sensitivity are 6.5 pm/°С and 1.1 pm/με, respectively. In addition, a 0.03 nm shift of the transmission dip can be obtained when the polarization state changes from X polarization to Y polarization.


Diffusing Wave Spectroscopy (DWS) is a novel modern technique uniquely suited for the non-invasive measurements of the particles size and their motion within the randomly inhomogeneous highly scattering and absorbing media, including biological tissues as a human skin. The technique is based on the illuminating the media (tissues) with a coherent laser light, and analyzing the loss of coherence of the scattered field arises from motion of the scattering particles with respect to each other. Both theoretical and experimental results has shown the potentialities and viability of DWS application for the express non-invasive quantitative monitoring and functional diagnostics of skin blood microcirculation, with down to 1 μm/sec resolution. This is likely lead to quantitative monitoring in general diagnostics, diabetes studies, pharmacological intervention for the failing surgical skin flaps or replants, blood microcirculation monitoring during sepsis, assess burn depth, diagnose atherosclerotic disease, and investigate mechanisms of photodynamic therapy for cancer treatment. In frame of current report we describe the recent developments of DWS further to the point that skin blood micro-flow can be routinely and accurately obtained in a separate skin vascular bed on normal skin tissues.


3-(4-Hydroxybenzyl)-8-methoxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one was prepared as a potential dopamine D4 receptor antagonist from 3-methoxyphenol,methyl-4-oxo-3-piperidine carboxylate hydrochloride and 4-hydroxybenzaldehyde through a two-step reaction and their structures were confirmed by infrared spectroscopy(IR),electrospray ionisation-mass spectrometry(ESI-MS),1H nuclear resonance spectroscopy(NMR) and elemental analysis.The results show that 8-methoxy-1,2,3,4-tetrahydrochromeno [3,4-c]pyridin-5-one(I) is the product of the intermolecular cycloaddition reaction between 3-methoxyphenol and methyl-4-oxo-3-piperidine carboxylate hydrochloride with yield of 49.2% under the conditions as follows: the molar ratio of n(3-methoxyphenol):n(methyl-4-oxo-3-pioerdine carboxylate hydrochloride):n(sulfuric acid) is 1:1:30,and reaction time is 48 h;and 3-(4-hydroxybenzyl)-8-methoxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one is the product of the N-alkylation reaction with yield of 51.8% under the conditions as follows: the molar ratio of n(I):n(4-hydroxy benzaldehyde):n(sodium triacetoxyborohydride) is 2:4:5,and reaction time is 20 h.


The study of Li Keran(1907-1989) is the hotspot question in the field of art academe in China recently,as for the study of Li Keran,is the series important question of the innovation of Chinese art in 20th century.I probed into the thoughts of education for the contribution in the field of landscape painting of China.The discussion of the part of thoughts of education for the landscape of Li Keran and proceed with the handwritings of his note,is probing into the 50 years of the career of teaching for paintings,the contribution of the national art rebounding.


This study is to clarify what kinds of factors are important to attract international conventions for Japanese researchers. Moreover, this study discusses the differences between those who have hosted international convention and those who are willing to host international convention in the future by using machine learning. Even though Japanese government has begun MICE promotion activities, researches on MICE industry are still limited and just get started in Japan. In analysis of the data, respondents are classified into 2 groups; those who have hosted international convention as experienced group and those who are willing to host international convention in the future as non-experienced group. A machine learning was used to analyze the difference of perspectives on the importance of site selection criteria between those who have hosted international convention and those who are willing to host international convention in the future. The results of machine learning show the differences between those who have hosted international conventions and those who are willing to host international conventions in the future.


We present an analysis of six polar coronal jets observed by the Ultraviolet Coronagraph Spectrometer (UVCS) at solar minimum (1996). Four of the events were also recorded by the Extreme-Ultraviolet Imaging Telescope (EIT) and/or the Large Angle Spectrometric Coronagraph (LASCO) C2 coronagraph. We compared the jets with others recorded in 1997. We modeled the observable properties of the jet from 1996 June 11, detected at 1.5 R☉. It represents a type of polar jet in which H I Lyα and O VI get brighter at the same time. The model reproduced the line properties with an electron density enhancement of a factor of 2 (with a resulting density of 4.8 × 106 cm-3), an outflow velocity enhancement of a factor of 3 (yielding a velocity of 200 km s-1), and an electron temperature decrease of a factor of 0.36 (with a resulting temperature of 5.3 × 105 K). We derived the jet's electron densities from the LASCO C2 white-light observations. They are a factor of 1.5 higher than in the interplume corona and comparable to those in plume regions within the C2 field of view. We developed a model for the origin of polar jets based on Wang's model for plumes. We envisioned that jets may be the result of short-lived bursts of base heating, while plumes may be the result of base-heating events that last longer than several hours. Models with the base heat flux near 3 × 105 ergs cm-2 s-1 come closest to matching the observations, though they are not entirely consistent.


The present study aimed to know the attitude towards ICT of user and non-user teachers of ICT. The data were collected from 40 (20 male and 20 Female) user and non-user of ICT secondary school teachers from Agra city. Attitude towards ICT was measured by Computer Attitude Scale (CAS), originally developed by Loyd and Gressard (1984). Data were treated by Mean, SD and t-test. The findings of study reveal that the ICT user teachers' attitude towards ICT is highly positive in comparison to ICT non-user teachers but they have also positive attitude towards ICT in relation to their school teaching subjects. It is clear that vast majority of secondary school teachers have positive attitude towards ICT in relation to their school teaching subjects for many reasons. Other important findings are also discussed.


During the first years after corporate social responsibility ("CSR") began to emerge as an issue for businesses in the 1980s, it was largely a self-regulated activity, with companies making their own decisions about how to manage and report on their environmental and social performance. While the achievements of some firms were impressive, overall there was skepticism about the honesty of corporate communications on their non-economic performance and many argued that corporate self-regulation was inadequate and that it made it too easy for firms to simply engage in public relations activities to improve their reputations as opposed to making a meaningful contribution to sustainable development and achieving social responsibility. One of the responses to these concerns was the ascendance of a new model of co-regulation which now includes partnerships of various types between companies and nonprofit organizations. In addition, nonprofit organizations have become important direct actors with respect to organizing and undertaking CSR-related initiatives.


The study aim is to use implicit-dynamic analyses and three dimensional finite element (FE) models for dynamic flexible pavement responses to various tire loadings quantification. This research goes beyond presenting conclusions to satisfy this objective-it raises valid questions and presents theories about "bottom-up" fatigue cracking and its initiations. Study considerations included three wheel loads (35.5 kN, 45.5 kN, and 53.5 kN), a tire pressure of 720 kPa, a wide-base tire (455/55R22.5), a dual-tire assembly (75/80R22.5), and two tire configurations. The study used pavement designs including three designs with hot-mix asphalt (HMA) thicknesses of 76, 152, and 305 mm and a typical interstate highway. There was simulation of two vehicle speeds (eight and 105 km/hr). Field-measured responses at the Virginia Smart Road were compared to calculated pavement responses. Study conclusions included that critical pavement response prediction occurs at low vehicle speed (8 km/hr) at high (40 degrees C) or intermediate (25 degrees C) temperatures, given that vehicle dynamics are not changing and pavement surface is smooth. Responses included vertical shear strain in HMA and tensile strains at the bottom of the HMA. For tensile strains at the bottom of HMA (38 mm from the surface) and vertical shear strains near the HMA surface under high speed (105 km/hr) at low HMA temperature (5 degrees C) resulted in greater response magnitudes than at low speed (8 km/hr). The transient moving loading high loading frequency (high speed), may exert, at low temperature (5 degrees C) higher inertia forces and acceleration to the pavement system responses than those at the low speed. Research shows that what is referred to as "bottom-up" fatigue cracking may be the result of vertical shear strains near the surface, while top-down cracking could be the result of surface tensile strains near the tire-edge rib. The study questions "bottom-up" fatigue cracking validity in relatively thick pavements as a result, and suggests that there may be initiation of these cracks at 50-100 mm below the HMA surface. This study's most important implication is that a fresh investigation of where these cracks are actually initiated is encouraged, and suggests that a primary pavement cracking distress cause may be "near-surface" cracking.


A pot culture experiment was conducted to study the effect of soil series on growth attributes of sweet corn in soils of Konkan (Maharashtra) during rabi season of years 2014-15 and 2015-16. The experiment was laid out in Randomized Block Design (RBD) with eight surface representative soils series viz., [Shahapur (S1), Palghar (S2), Roha (S3), Repoli (S4), Shirgaon (S5), Lanja (S6), Deogad (S7) and Vengurla (S8)] for experimental study. The physic-chemical properties of the representative soil series viz., pH of soil ranges from 4.85 to 7.08, electrical conductivity (EC) where the maximum value was noted to be 0.35 dS m-1. The organic carbon content of the surface soils ranges from 4.8 to 11.5 g kg-1 while, the soils were sandy loam to clay loam; few were clay in texture. Clay content of the surface soil was ranged from 19.2 to 47.4 per cent with a mean value of 33.52 per cent.Soils were in general medium sandy loam to clay loam texture and slightly acidic to neutral in reaction. The organic carbon content of the soils varied from 4.80 to 11.5 g kg-1 in surface soils. Periodical observations on various growth attributes and yield i.e. growth parameters (viz., plant height, number of functional leaves and dry matter accumulation) of sweet corn recorded at 30 DAS, 60 DAS and after harvest of sweet corn. The Palghar soil series (S2) recorded maximum plant height, no of functional leaves, dry matter accumulation and fodder yield of sweet corn.


AbstractIn this study, the different aluminum (Al) species generated during electrocoagulation (EC), the humic acid (HA) removal, and the change in HA characteristics were evaluated. The results show that the distribution of monomeric Al species (Ala), medium polymer Al species (Alb), and colloidal or solid Al species (Alc) was dependent on initial pH and current density (CD). The higher the fraction of Alb and Alc, the faster the HA removal. The fraction of Alb and HA removal rates were higher at an initial pH of 4.5 than at 6.5. At a CD of 29 A m−2, the fraction of Alb and Alc was higher and HA removal was faster than at 5 A m−2. The results of UV/Vis spectroscopy, fluorescence spectroscopy, and size-exclusion chromatography show a decrease in aromaticity, degree of conjugation, and average molecular weight after EC treatment. The decreases were more pronounced at a high CD than at a low CD, indicating that Alb and Alc, especially Alc, contribute much to the preferential removal of highly condensed and ...


Yangtze Delta Region is well known for its unparalleled vitality of innovation in China,Based on the convergence theory and patent data,this paper examined whether the difference of innovation ability among 16 cities in the region is diminishing.The test results indicated the existence of σ convergence in both patents granted and patents accepted;The results of panel data analysis presented no evidence of absolute β convergence in either type of patents.The estimation results from the robust GMM first-order differentiation two-step method revealed the existence of conditional β convergence for both types of patent,however.The converging speed for patents granted was found faster than that of those accepted.In the end,it was proposed that the key to reduce regional disparity in innovation was to continually strengthen the capability of independent innovation.


While pandemics have profoundly affected societies and the individuals that make up this society throughout the history of humanity, they have hit not only health, but also economic and social activities. As in our country, in traditional societies, people are firmly connected to verbal communication in the family, their friendship, their long-term neighborhood and all other social communications that will meet their need for information. In the pandemic process in which social communication was limited, the flow of information from these sources of information was limited, and the media was replaced by a great deal of it. Media in modernized society; It contains many features related to social life such as information and informing, socializing, contributing to public formation, education and entertainment. In this study, during the Covid-19 pandemic process seen in our country and all over the world, the media tools that individuals use to get information about the disease are different individuals' gender, age, marital status, province, educational status, occupational knowledge, language they know, the number of people they live within the family. It is aimed to determine the family in terms of variables such as total income range. For this purpose, in this study, the relational screening method was chosen, and the exploratory model was used among the relational screening types. According to the results obtained, it was determined with this study that we should choose media tools for the layer of the society that we would like to reach the society through the media. If it is desired to reach the married, elderly, women, low-income and poorer education groups, it is possible to choose television channels as the most important media tool, if it is desired to reach young people, singles, well-educated groups and high-income groups, social media, especially Twitter. It was concluded that it would be beneficial to use it. When it is desired to choose a social media tool for individuals under the age of 15, it is concluded that Instagram and Youtube can be used, and Facebook and WhatsApp can be used as the most effective tools for the older age group. Keywords: Pandemic, Covid-19, Media Tools, Social Media, Exploratory Model


Reinforcement learning needs to learn policies through trial and error. The unstable policies in the early stage of training make it expensive (and time-consuming) to train directly in the real environment, which may cause disastrous consequences. The popular solution is to use the simulator to train the policy and deploy it in a real environment. However, the modeling error and external disturbance between the simulation and the real environment may fail the physical deployment, resulting in the sim2real transfer problem. In this letter, we propose a novel robust adversarial reinforcement learning framework, which uses the ensemble training of multi-adversarial agents that can adaptively adjust adversaries' strength to enhance RL policy's robustness. More specifically, we take the accumulative reward as feedback and construct a PID controller to adjust the adversary's output magnitude to perform the adversarial training well. Experiments in the simulated and the real environment show that our algorithm improves the generalization ability of the policy for the modeling error and the uncertain disturbance simultaneously, outperforming the next best prior methods across all domains. The algorithm was further proven to be effective in a sim2real transfer task through the load experiment of a real racing drone, and the tracking performance is better than the PID-based flight controller.


Research on formalin analy s is of  food ingredients in Palu has been conducted. The purpose of the research is to find out formalin content in some food. The analyzed samples were foods that marketed in Palu , such as salt fish, noodle s , mujair fish , and tofu obtained from s everal places in Palu. The qualitative analysis of formalin done before measured of formalin quantitatively . The data on formalin found by UV-Vis spectro ph otometer with the wavelength of 385 nm. Formalin content of salted fish, noodles,  Mujair fish, and tofu were 2,005 ± 0,187 ppm, 2,183 ±0,231 ppm, 1,931 ±0,174 ppm, and 1,957 ±0,254 ppm, respectively.


1. In this note we prove convergence theorems for smoothing operators (conditional expectations) in the space of continuous functions. In this setting conditions which imply uniform convergence are found; indeed, in the form that the problem is set the conditions are necessary and sufficient. We give examples showing that many of the properties of conditional expectations on a measure space no longer hold in C(X).


Soliton collisions in birefringent optical fibers have been investigated numerically. It is found that soliton collisions can be divided into three kinds of behavior depending on the value of the linear birefringence. Both soliton mixing and soliton center-frequency shifts have been studied in detail. A new kind of soliton state has been found. The Cerenkov emission generated by soliton collision has also been found numerically.


TeeChart Pro control is applied to turntable interface control program.The programmed interface provided by control can be used to change curve display rate,refresh screen display of data,and adjust curve amplitude and so on.The trace curve can be displayed in real time during the turntable running.It can ensure the running track output without distortion.The application and utilization of TeeChart Pro control as virtual oscillograph was presented.


Although one is unlikely to ever want to brute-force an Android lock pattern, many do wonder about the relative strength of the lock pattern versus a multi-digit personal identification number (PIN). It becomes obvious pretty quickly that there are many more lock patterns than the 10,000 possible four-digit PINs. (see PDF for full technology corner)


A trigonometric series method is one of the widely used methods for calculating the artificial ground motion.But when using this method for calculating the speed of time,it is found that there exists the zero-line drifting phenomenon.Based on the prodecessor's researches,a kind of more perfect model for the strength envelope function is proposed,to resolve this problem much better.Through the calculation,it is proved that the new method is reasonable and effective.


Background: trALL is an important secondary primary malignancy (SPM) that has recently been appreciated. While patients (pts) with MM have an 8%-17% risk of developing an SPM while on lenalidomide (R) maintenance following autologous stem cell transplant (ASCT), trALL has been rarely observed. Little is known about the characteristics of trALL in pts with MM compared to pts who had other malignancies prior to the development of trALL. We define tALL as any prior exposure to cytotoxic chemotherapy and/or radiation for another malignancy, and herein, we report a comparative analysis of characteristics and outcomes of pts with trALL with and without MM from the Mayo Clinic Cancer Center (MCCC).

 Methods: We performed a systematic search in the 3-site MCCC registry and included all pts diagnosed and received at least 1 cycle of ALL-directed therapy and/or underwent allogeneic transplantation (AlloHCT) for ALL between 2007-2020. All cases of trALL in this series are B-ALL. Comparisons of characteristics between trALL patients with and without MM were made using a Wilcoxon rank sum test (continuous variables) or Fisher's exact test (categorical variables). Time-to-event variables were compared using unadjusted Cox proportional hazards regression models.

 Results: 70 trALL pts (14 MM [20%], 56 non-MM [80%]) were identified during the study period. The median age at trALL diagnosis was 63.9 (range 47-71) for MM pts and 63.1 (range 18.2-84) for non-MM pts. Median follow-up from trALL diagnosis was 1.42 years (range 0.02-10.6 years). The most common prior non-MM malignancies among tALL pts were breast (28.6%), lymphoma (17.9%), myeloid (17.9%), and GU/GYN (14.3%). Amongst the 14 MM pts, 100% (n=10) had ISS-I disease, 8 (57%) had IgG K MM, 1 (n=10) had high risk cytogenetics, 8 (57.1%) received R-based induction , 4 (28.6%) received CyBorD induction, 4(28.6%) received VRD induction, 3 (21.4%) received RD induction. 10 (71.4%) pts were actively on R when they developed trALL, 8 (57.1%) pts received prior ASCT. The median time to develop trALL following ASCT for MM was 46.3 months (m), (95% CI 20.4-67.6), 12 (85.7%) pts received R maintenance with a median duration of 53m (95% CI 16.9-121). The median time to develop trALL after initiation of R maintenance was 61.2m (95% CI 16.9-123.4). The most common trALL induction regimen received was HyperCVAD which was used in 71.4% of MM pts and 51.8% of non-MM pts. In comparison to non-MM pts, MM patients had a significantly lower WBC at diagnosis (Median: 2.0 vs. 5.8, P=0.005),no t(9;22) BCR/ABL1 cytogenetics (0.0% vs. 35.7%, P=0.008), a higher frequency of hypodiploid/near-triploid (Ho-Tri) cytogenetics (42.9% vs. 12.5%, P=0.009), and a lower frequency of prior radiation therapy (7.1% vs. 44.6%, P=0.012). MM pts had a higher frequency of AlloHCT for trALL (71.4% vs. 42.9%, P=0.075) and were more commonly in complete response (CR) at transplant (100.0% vs. 70.8%, P=0.078). No trALL in MM pts were Ph-like ALL. There was a statistically significant difference in time to development of trALL between previous malignancy locations (P=0.018), with GU/GYN (Median: 9 years) having the longest time and myeloid (Median: 3 years) having the shortest time; MM was 6 years. In the overall pt cohort, 56 (80%) pts achieved a complete response after induction and 60% (n=25) were minimal residual disease (MRD)+ after induction. Pts with MM had a significantly lower likelihood of being MRD+ after induction (OR=0.09, P=0.015). Overall, 24.3% of pts relapsed after induction therapy for trALL; 39 (55.5%) died after trALL diagnosis including 43% (n=35) who died after AlloHCT. Although pts with MM tended to have better outcomes compared to non-MM trALL pts in terms of overall survival after trALL diagnosis (Figure 1A), survival after AlloHCT (Figure 1B), relapse rate after trALL diagnosis and non-relapse mortality after AlloHCT, none of these findings were statistically significant in this small cohort (Figure 1C).

 Conclusion: trALL is a unique SPM that can occur in pts with MM. It is associated with Ho-Tri cytogenetics and is BCR/ABL1 negative. The majority of MM pts that developed trALL had undergone prior ASCT and were on R maintenance when they developed trALL. Despite being more likely to have adverse cytogenetics features, MM-associated trALL has similar survival compared to non-MM-associated trALL which speaks to the poor survival outcomes of this SPM. Further research on trALL in MM pts is merited.
 Figure 1 Figure 1.

 Litzow: Amgen: Research Funding; Pluristem: Research Funding; AbbVie: Research Funding; Actinium: Research Funding; Astellas: Research Funding; Omeros: Other: Advisory Board; Jazz: Other: Advisory Board; Biosight: Other: Data monitoring committee. Bergsagel: Janssen: Consultancy. Fonseca: Scientific Advisory Board: Adaptive Biotechnologies: Membership on an entity's Board of Directors or advisory committees; Caris Life Sciences: Membership on an entity's Board of Directors or advisory committees; AbbVie: Consultancy; Patent: Prognosticaton of myeloma via FISH: Patents & Royalties; Bayer: Consultancy; Takeda: Consultancy; Celgene: Consultancy; Amgen: Consultancy; BMS: Consultancy; Mayo Clinic in Arizona: Current Employment; Juno: Consultancy; Kite: Consultancy; Aduro: Consultancy; OncoTracker: Consultancy, Membership on an entity's Board of Directors or advisory committees; GSK: Consultancy; Novartis: Consultancy; Merck: Consultancy; Sanofi: Consultancy; Pharmacyclics: Consultancy; Janssen: Consultancy. Dispenzieri: Takeda: Research Funding; Alnylam: Research Funding; Pfizer: Research Funding; Oncopeptides: Consultancy; Sorrento Therapeutics: Consultancy; Janssen: Consultancy, Research Funding. Murthy: CRISPR Therapeutics: Research Funding. Ailawadhi: GSK: Consultancy, Research Funding; Sanofi: Consultancy; Pharmacyclics: Consultancy, Research Funding; Takeda: Consultancy; Medimmune: Research Funding; Xencor: Research Funding; Genentech: Consultancy; Janssen: Consultancy, Research Funding; Amgen: Consultancy, Research Funding; Cellectar: Research Funding; Beigene: Consultancy; BMS: Consultancy, Research Funding; AbbVie: Consultancy; Karyopharm: Consultancy; Ascentage: Research Funding. Foran: actinium: Research Funding; taiho: Honoraria; bms: Honoraria; servier: Honoraria; pfizer: Honoraria; novartis: Honoraria; OncLive: Honoraria; abbvie: Research Funding; boehringer ingelheim: Research Funding; takeda: Research Funding; trillium: Research Funding; aptose: Research Funding; revolution medicine: Honoraria; syros: Honoraria; sanofi aventis: Honoraria; certara: Honoraria; gamida: Honoraria; kura: Research Funding; h3bioscience: Research Funding; aprea: Research Funding; sellas: Research Funding; stemline: Research Funding.


Aim To research analgesic and anti-inflammatory effects of total saponins of yinfenglun.Methods The models of inflammation were established to observe anti-inflammatory effect. Hot-plat method and acetic acid was used to observe effect of analgesic.Results Total saponins of yinfenglun at different doses could reduce the capillary permeability of mouse significantly,and showed ameliorated tendency to ear swelling induced bydimethylbenzene in mouse,swelling of joint induced by carrageenen in rats.However,there is no analgesic effect on pain.Conclusion Total saponins of yinfenglun has some anti-inflammatory effect, but no obvious analgesic effect.


In the article basic trends of the insurance companies' activity during 2000-2008 years are probed and also the quality estimation of the of insurance market development are been realized.


The results of the preceding investigation [Paper 5A4, this meeting] indicated that, with the floor absorptive, the suspended panels and the diffusers (located in the space below the panels) would greatly affect the quality of music and the intelligibility of speech. Recordings of speech and music (a trumpet, a violin, and the Roth String Quartet) in the anechoic chamber, played back in the reverberation room, under conditions that we had previously investigated, revealed some interesting and probably useful results. For example, speech articulation and the quality of music were greatly improved by introducing diffusion in the lower space. even though the "reverberation time" (estimated by projecting linearly the early decay to 60 dB) was of the order of 3.0 sec. The results are demonstrated with tape recordings; they suggest that large diffusers may have a more useful effect on room acoustics, for speech as well as music, than we have generally supposed.


The foregoing discussion is concerned with normal deviations from reality in contemporary social life and the useful purposes which these serve. The author is not in agreement with those who believe that good mental health must be based upon realistic conceptions of environment and self. It is the present theory that individuals and groups normally develop biases consistent with their standards and purposes. This tendency involves elements of unreality but it favors mental health and high morale in society.


We study the pairing mechanism in iron pnictide superconductors based on the five-orbital Hubbard-Holstein model. Due to Fe-ion oscillations, the $s$-wave superconducting (SC) state without sign reversal (${s}_{++}$-wave state) is induced by orbital fluctuations by using realistic model parameters. The virtue of the present theory is that the famous empirical relation between ${T}_{c}$ and the As-Fe-As bond angle is automatically explained since the electron-phonon coupling that creates the orbital fluctuations is the strongest when the ${\text{As}}_{4}$ tetrahedron is regular. The negative iron isotope effect is also reproduced. In addition, the magnitude of the SC gap on hole pockets is predicted to be rather insensitive to the corresponding $d$ orbital ($xz/yz$ or ${z}^{2}$ orbital), which is consistent with the recent bulk-sensitive angle-resolved photoemission spectroscopy (ARPES) measurement for $(\text{Ba},\text{K}){\text{Fe}}_{2}{\text{As}}_{2}$ and ${\text{BaFe}}_{2}{(\text{As},\text{P})}_{2}$. These obtained results indicate that the orbital fluctuation mediated ${s}_{++}$-wave state is a plausible candidate for iron pnictides.


Sickle cell crisis is preventable most of the times. However, in Bahrain sickling crisis is the most complained and cause of hospital admission. No data is available regarding the extent of knowledge and attitudes towards the sickling crisis's preventive measures the adult Bahraini sickle cell patients have. The purpose of this paper is to explore the extent of knowledge and attitude of Bahraini adult sickle cell patients towards the preventive measures of sickle cell crisis. The objective is to establish baseline data and to utilize the findings in designing awareness programs that would assist the sickle cell patients to prevent the sickling crisis. A convenient sample of 84 Bahraini adult sickle cell patients achieved. Structured interview approach was used to assess the subjects©knowledge and attitudes toward the preventives measures of sickle cell crisis. The results indicated that the sample was moderately knowledgeable about the sickling preventive measures (Mean of Knowledge score = 55%) and moderately compliant (Mean of Attitudes score = 63%). The subjects© knowledge (about the preventive measures) was found to be moderately and positively correlated (r = 0.57, r2 = 0.32, p = 0.000) with their attitudes toward crisis prevention. Designing awareness programs regarding the preventive measures of sickle cell crisis is an evident need for these patients.


Restoration in the resort area of Sei Betung covers 9.734 hectares. Various attempts were conducted to rehabilitate to the area, such as replanting or utilizing spreading seed agent of bird. The presence of a certain bird species, generally followthe preference on it's habitat. This research observed  what kind of bird perched on artificial perch and  weather conditions in the area. The methodology used Ponctuels d'Abondance / Index Point of Abundant (IPA-Count), thas did not require extensive sampling place or a certain squares wide. This method consisted a series of points that spreaded randomly or in straight line. The results obtained the highest diversity of trees is 1,20, the highest bird abundance merbah cerucuk 31,67. Birds conducted their activities in  temperature range between 26,5 0 C - 31 0 C and humidity around 70% and precipitation of 74,857mm. Keywords: Restoration, species of bird, temperature, humidity, rainfall


The research on tourism ethics in foreign countries has been mainly oriented by the practice,focusing on the subject,principle,norm and practice.The research on tourism ethics at home mainly deals with the construction of tourism ethics theory and ethical norm,the practical exploration on code of ethics and tourism ethics education.Some problems are found in these researches.For instance,the object of research on tourism ethics is not clear;the key is underemphasized;there is a lack of philosophical comments;virtue ethics is neglected and there is a demand for multiple basis theory.To tackle these problems,the paper suggests that we need to distinguish tourism activities from tourism operational activities,strengthen practical ethics problem orientation,making philosophical reflection and critique,attach more importance to virtue ethics study and enrich tourism ethics theory so as to promote research on tourism ethics.


The use of natural dyes is a field of great interest to solve the problems related to environment pollution and health risks. The objective of this research was to study the plasma discharge of double dielectric barrier (DDB) to modify the fabrics surfaces of polyamide 6.6 (PA66), silk (SK) and cotton (CO) dyed with leaf extract of teak (Tectona grandis). It was also aimed the improvement in the penetration and fixation properties to the natural dyes even without using metal mordants, which are toxic and usually used in this type of dyeing. The dye extract obtained from the teak leaves was chemically characterized by using UHPLC/QTOF-MS. The color parameters were calculated by means of spectroscopy to evaluate the color intensity (K/S) and its fastness was evaluated for washing, friction and perspiration.


The present invention relates to blind source separation. More particularly, the present invention relates to a blind source separation using the frequency domain process. .FIELD 1


From the earliest days of Captain Cook's explorations in the Pacific and the beginning of white colonisation, through to the bushranger, Ned Kelly and the famous boxer, Les Darcy, Australia's history abounds with step dancing. Step dancing was fashionable on the stage, in dance schools, and in the community, and musicians around the country played for people to dance "a bit of a step". The first white settlers to Australia brought with them their popular culture and this was quickly established, with dance featuring as a favourite pastime. As the colony developed there was a significant gender imbalance though this did not abate the enthusiasm for dance. There are plenty of stories about men gathering in pubs to dance (and drink) and as the Gold Rushes brought even more men to the colony, dance competitions became prevalent. This coincided with the clog dancing revolution in Britain with many migrants bringing steps to the new land, and dancers from the Antipodes travelling to compete in the old. Prime examples of this are Harry Macklin Shaw, the boy from Lancashire who became the clog dancing champion of Australia and the forbear of Craig Revel-Horwood; and the darling of Sydney, Bella Perman, who competed for the championship of England in 1898. Dr Heather Blasdale-Clarke examines the story of step dance in Australia and the vestiges that remain of a once vibrant culture, where 18,000 people gathered to watch the Great Inter-colonial Clog Dancing Championship of 1869.


The current grid security development was researched,and the Identity Based Encryption(IBE) and the Public Key encryption(PKE) were analyzed.Concerning the grid characteristics and development,a hierarchical ID-based Encryption for Grid scheme was proposed,and its safety and efficiency were analyzed.


Abstract : The invention refers to the field of air conditioning and regards an apparatus for obtaining cooled water. The purpose of the invention is to develop such a system for obtaining cooled water which would permit the maximum use of the cooling effect of the water-cooling tower.


Effect of feeding polyphenols on Campylobacter counts in broilers P. Vazquez, C. Millán, F.J. García-Peña, M.J. Cubero, J. Sánchez Imasde Agroalimentaria, S.L., Spain Laboratorio Central de Veterinaria de Algete, Spain Facultad de Veterinaria, Universidad de Murcia, Spain *Corresponding author. Email: email@example.com Two experiments were conducted to evaluate the effect of a blend of polyphenols (P; 90% gallic acid, catechin and epicatechin) on Campylobacter counts in broilers. There were three treatments (T1: Non infected, T2: Infected and T3: Infected + P). Polyphenols were applied either to the whole experimental period (1-42 d, P at 238 ppm; Exp. 1) or exclusively in the finisher diets (21-41 d, P at 159 ppm; Exp. 2). Birds from T2 and T3 were infected at 14 d with 100 μl of a solution containing 10 CFU/ml of C. jejuni strains (ST-21 and ST-45). Ten broilers per treatment were euthanized and caecum removed for Campylobacter enumeration at 7, 21 and 28 d after inoculation. In Exp. 1, P supplementation significantly decreased log CFU/g of Campylobacter at 7 d (7.13 vs 7.84 log10; P = 0.0391), 21 d (7.25 vs 8.11 log10; P = 0.0316) and 28 d post-infection (6.80 vs 7.6 log10, P = 0.0353). However in Exp. 2, P supplementation only a numerical decrease of Campylobacter infection at 35 and 42 d was observed, but differences were not significant. It is concluded that supplementation of broiler diets with a blend of polyphenols decrease Campylobacter colonization in broilers. However more research is needed regarding dosage and supplementing period.


computer in teaching, and in industrial uses of physical properties of and composites, processing of and metal removal, engineering and design, metal in and power mission and


Whilst autologous stem cell transplantation (auto‐SCT) is considered standard of care for relapsed/refractory classical Hodgkin lymphoma, the role of auto‐SCT in nodular lymphocyte‐predominant Hodgkin lymphoma (NLPHL) is not well defined due to limited data. We report the first study on auto‐SCT for NLPHL with a larger cohort. Eligible for this retrospective registry study were patients reported to the EBMT between 2003 and 2013, aged 18 or older with relapsed/refractory NLPHL who underwent first auto‐SCT with disease chemosensitive to salvage therapy. NLPHL transformed to diffuse large B cell lymphoma were excluded. Sixty patients (83% male; median age 40 years) met the eligibility criteria. The median time between diagnosis and transplant was 21 months (IQR 13–58), and the median number of prior treatment lines was 2 (range 1–5), including rituximab in 63% of the patients. At auto‐SCT, 62% of the patients were in complete remission (CR) and 38% in partial remission. Seventy‐two percent of the patients received BEAM as high‐dose therapy. With a median follow‐up of 56 months (range 3–105), 5‐year progression‐free and overall survival (OS) were 66% and 87%, respectively. Univariate comparisons considering age, time from diagnosis to transplant, prior chemotherapy lines, and prior rituximab use failed to identify significant predictors for any survival endpoint except for being in CR at the time of auto‐SCT (vs PR, P = .049) for OS. Auto‐SCT in patients with relapsed/refractory NLPHL who are sensitive to salvage therapy gives excellent disease control and long‐term survival independent of the time interval between diagnosis and transplant.


I-wk -yhether a product of the % f \ I globalization of trade and T T commerce, military ser vice, immigration, or recreational travel, international custody and sup port-enforcement cases are becom ing more commonplace. To accom modate their resolution, the United States has become a member of international judicial assistance conventions for the prevention of child abduction by parents, service of process, obtaining evidence, and legalization of documents. Although not always perfect in their applications, these conventions facil itate enforcement of custody and access orders in member foreign jurisdictions. The United States has been an active participant in the Hague Conference on Private International Law Special Commissions, convened in 1995 and 1999 to study existing support conventions with a view toward improving them and attract ing new members. However, the U.S. has not acceded to any of these sup port conventions and in lieu thereof is pursuing bilateral arrangements. Welfare reform legislation in 1996 authorized the U.S. Secretary of State, with the concurrence of the Secretary of Health and Human Services (HHS), to enter into child support establishment and enforce ment arrangements with foreign countries. Pub. L. No. 104-193, ? 371; 42 U.S.C. ? 659A. At this writ ing, the U.S. has arrangements with the Canadian provinces of British Columbia, Manitoba, and Nova Scotia, Czech Republic, Ireland, Poland, and the Slovak Republic. An agreement with Portugal will come into effect 30 days after the Depart ment of State receives a diplomatic note advising that Portugal has enact ed domestic legislation implement ing the arrangement. According to Gloria F. DeHart, attorney adviser to the Department of State and chief negotiator of fed eral child-support arrangements, Australia, the Netherlands, and Norway should soon be foreign re ciprocating countries. These arrange ments include child and spousal sup port, although the latter is expressly left at the state support enforcement agency's option. As of April 1, 1998, all states have adopted the Uniform Interstate Family Support Act (UIFSA) as modified on July 18, 1996, by the National Conference of Com missioners on Uniform State Laws. The act defines "State" to include a


This paper argues that heat flow is a valid 'potential field method' for mineral exploration. Certain ore deposits, most notably iron oxide copper gold uranium (IOCG-U) deposits, demonstrably affect the local heat flow and ground temperature conditions. The physics of steady state conductive heat flow is mathematically the same as gravitational acceleration, with buried heat sources analogous to buried masses. Detecting the surface signature of a buried heat source can therefore yield direct evidence of an ore body. The physics is robust, appropriate tools exist for the collection of heat flow data for exploration, and some simple strategies could yield valuable additional information about the subsurface for small marginal cost.


Public institutions guaranteed exclusive position of core business are likely to be inefficient in management. Past governments made various efforts to innovate public institutions. Participatory government drove innovation of public institutions through Ministry of Planning and Budget, and this innovation policy had problems as followings: shortage of common sense of innovation, lack of understanding of innovation, gradual execution of innovation instead of system innovation for business innovation, lack of consideration of characteristics of various public innovation, overlapping of evaluation system, and nonobjective design of evaluation indicator. MB government has diverse assignments for improvement of these problems as followings: transformation of business mind, voluntary participation of employee, improvement of management system of public institutions, reform of business evaluation system, promotion of internal competition, and construction of performance based business system. What is the most important point for successful reform of public institution is to achieve the support of general public with effective action plan and substantial programs.


The present invention provides an aluminum alloy board used by battery cap. When the aluminum alloy board is used as the raw material for manufacturing the cover used by battery casing, the thin-wall explosion-proof part of aluminum alloy used by battery cap can be obtained through wholly punching. The aluminum alloy board comprises 1.15-1.35wt% of Fe and 0.40-0.60wt% of Mn. Furthermore according to the requirement, the aluminum alloy board comprises 0.005-0.15wt% of Ti or 0.005-0.15wt% of Ti and 0.0005-0.05wt% of B, and the balance of Al and impurity. The impurity comprises Si, Cu and Mg. The content of Si is limited to less than 0.05wt%. The content of Cu is limited to less than 0.05%. The content of Mg is limited to less than 0.05wt%. To the tissue with the above composition, the maximum width of crystal grain is adjusted to less than 100 mu m and the average width is adjusted to less than 25 mu m through adjusting the manufacturing condition.


Submitted for the MAR08 Meeting of The American Physical Society Determining behaviors of biological networks with dynamic logic method. SUPING LYU, Medtronic Inc — Dynamic logic method was used to study dynamic behaviors of some network motifs. This method combines logic operations and kinetic parameters of biological interactions (response or delay times). The analysis is simple because it is pure symbolic operation without numerical calculation. We proved in general that if networks are cycles with an odd number of suppression interactions, the cycles will oscillate. Delay times are necessary for oscillatory networks. If delay times are zero, the systems stay at stable states. If there are an even number of suppression interactions, the cycles have two stable states. Signal travel in chain-like networks was also studied. The depths of travel depend on the pulse width of signals and the filters of chains. Same signals with different pulse widths can have different biological responses (one stimulation to multiple responses). When pulsive signal travel in cycles, they can remain to be pulses, die, or become flat (all active) depending on the filters of cycles. The coupled cycles have complicated behaviors that are determined by their intrinsic structures and filters. Interestingly, chaotic behaviors were very rarely observed from analysis. SuPing Lyu Medtronic Inc Date submitted: 27 Nov 2007 Electronic form version 1.4


A theoretical feasibility study into the possibility of using magnetic impurity relaxation of Fiske modes in Josephson junctions as a spectroscopic probe for type I superconductors is described. It is estimated that concentrations of less than 100 ppm magnetic impurities might be measured.


BACKGROUND AND OBJECTIVES
Due to the increasing demand for biomarkers in breast cancer we screened the TP53 targetome to discover some novel biomarkers, if any.

METHODS
For this purpose, a TP53 targetome dataset was downloaded and a protein-protein interaction network (PPI) was constructed and analyzed to identify the hub genes. In total 33 hub genes were identified and subjected to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. The information related to the expression and promoters' methylation profiles of the hub genes was retrieved through UALCAN. Genetic alteration and copy number variations (CNVs) related information was obtained from the cBioPortal. While KM plotter tool helped to evaluate the prognostic potential of the identified hub genes.

RESULTS
The KEGG pathway analysis revealed the enrichment of hub genes in various diverse pathways. The expression analysis showed that the expression profile of majority hub genes was similar to the one as reported in the published literature. While, a few hub genes (CDKN1A, BRCA1, CHEK2, PMAIP1, TNFRSF10B, CHEK1, GADD45A, IGFBP3, CASP3, and FOXO3) exhibited differential expression profile and examined to have prognostic values, hence, suggested as novel potential biomarkers of BRIC. Moreover, the correlational analysis revealed some unusual correlations among expression levels and promoters methylation status of many hub genes.

CONCLUSION
Our study has extended the database of breast cancer biomarkers by providing insights into some novel diagnostic and prognostic biomarkers having potential of clinical implementation.


PURPOSE: An emergency guide line emitting continuous line type light and a manufacturing method thereof are provided to conveniently install and maintain an emergency guide line emitting continuous line type light. CONSTITUTION: A main body(10) forms a plurality of receiving grooves on which an EL wire(30) is mounted. A cover(20) closes the top of the main body while the EL wire is mounted on a receiving groove of the main body.


The acupuncture and moxibustion therapy are often recommended to treat some neuronosis as routine treat or rehabilitation, but we don't know what is the indications According the investigation of textbook of neurology and up-to-date medical journal,to recommend that 25 kinds neuronosises can be treated by acupuncture and moxibustion therapy, for example, sciatica or Bell,s palsy, etc. Another 47 kinds neuronosises can be tried to research.


The development of aircraft secondary power technology is moving from mechanical power, pneumatic power and hydraulic power to electric power. The trend toward electric power is known as More Electric Aircraft (MEA). Modern military aircraft are designed using 270VDC for electric power system. Today, some military aircraft still use 115VAC/400Hz for their electrical power system. If this type of aircraft need provides 270VDC electrical power, then they require Multi-Pulse Transformer Rectifier Unit (TRU). The development of this type TRU has not been aimed to comply with aircraft military standards. This research investigates the variation of the number of pulses (p) and firing angle (α) to the amplitude ripple voltage, output voltage, and distortion factor in order to comply with the MIL-STD-704F standards. The multi-pulse transformer rectifier unit being analyzed consists of 6-Pulse and 12-Pulse. The research shows that the amplitude ripple voltage and distortion factor of the 6-Pulse TRU do not comply MIL-STD-704F. The amplitude ripple voltage and distortion factor of 12-Pulse comply MIL-STD-704F with firing angle (α) ≤4°.Keywords: Transformer Rectifier Unit, thyristor, ripple voltage, distortion factor, firing angle


The educational ideal of the modern school aims at training personalities with creative and innovative potential. Online teaching games are attractive in the organization and development of the educational process, requiring the manifestation of an original, innovative thinking. They offer  the possibility of integrating information technologies with the field of Natural Sciences, presenting a form of STEM training.


The present invention provides a method of controlling a media processing apparatus, the media processing system and the media processing apparatus. Media processing device (2) of the overall control unit (35) comprises a flag in a case where identification information is uniquely assigned including information written in the IC tag writing completed normally, as for write completed storing information in the IC tag, on the other hand, during the writing of the write information of the IC tag is read out tag identification information from the IC tag, the tag determines whether there is identification information stored in the read and a case where the tag identification information coincides information, consistent with the presence of the write-inhibit information writing information. Accordingly, the information can be prevented from an IC tag mounted in a medium capable of performing wireless communication while not targeted but has been normally written is overwritten, so as to become the error information in the information stored in the IC tag.


Electron paramagnetic resonance (EPR), electron‐nuclear double resonance, optical absorption, and thermoluminescence have been used to investigate radiation‐induced point defects in a single crystal of lithium triborate (LiB3O5). Two prominent defects are observed after irradiation near liquid‐nitrogen temperature with 60 kV x rays. A four‐line EPR spectrum, with 12.2 G splittings, is assigned to a trapped‐hole center, and another four‐line EPR spectrum, with 120 G splittings, is assigned to a trapped‐electron center. In each case, the nucleus responsible for the observed hyperfine is 11B. The trapped hole is localized on an oxygen ion and has a weak hyperfine interaction with one neighboring boron nucleus, whereas the trapped electron is localized primarily on a boron ion with a correspondingly larger hyperfine interaction. Both defects become thermally unstable near 125 K, and their decay (i.e., recombination) correlates with an intense thermoluminescence peak at this same temperature. An optical absorp...


Members of the genus Nocardia are associated with the group of microorganisms known as the aerobic actinomycetes and belong specifically to the family Mycobacteriaceae . The nocardiae contain tuberculostearic acids but differ from the mycobacteria by possession of shorter-chained (40- to 60-carbon)


Increasing data rate in wireless networks (e.g., vehicular ones) can be accomplished through a two-pronged approach, which are 1) increasing the network flow rate through parallel independent routes and 2) increasing the user's link rate through beamforming codebook adaptation. Mobile relays (e.g., mobile road side units) are utilized to enable achieving these goals given their flexible positioning. First at the network level, we model regularized Laplacian matrices, which are symmetric positive definite (SPD) ones representing relay-dependent network graphs, as points over Riemannian manifolds. Inspired by the geometric classification of different tasks in the brain network, Riemannian metrics, such as Log-Euclidean metric (LEM), are utilized to choose relay positions that result in maximum LEM. Simulation results show that the proposed LEM-based relay positioning algorithm enables parallel routes and achieves maximum network flow rate, as opposed to other conventional metrics (e.g., algebraic connectivity).Second at the link level, we propose an unsupervised geometric machine learning (G-ML) approach to learn the unique channel characteristics of each relay-dependent environment. Given that spatially-correlated fading channels have SPD covariance matrices, they can be represented over Riemannian manifolds. Consequently, LEM-based Riemannian metric is utilized for unsupervised learning of the environment channels, and a matched beamforming codebook is constructed accordingly. Simulation results show that the proposed G-ML model increases the link rate after a short training period.


Soil, as the nature body, is very important in supporting the live perpetuity of the living creatures. In farm machinery and equipment application for soil tilling, soil also affects the goal of the soil tillage activities. When the soil tillage equipment and machinery are to be applied in the field. there will Qe interaction among the traction device, the blade, and the soil. The soil, which is used as a machine supporter, must have a certain consistency. Consistency is the degree of cohesion and adhesion among soil partides and soil mass resistance to the variation of shape by pressure and strength, that affected the soil deformation.


Combined with social development and variation,stood on historical and social aspects,the developing course of British congregated house was illustrated and Chinese and British residential development was compared.It pointed out that policy theory and developing practice of British congregated house accumulated experience for Chinese present reform and complete of housing system.


This research is a comparative research, which is aimed to obtain an empirical evidence about whether there are significant differences between traditional ratios and cash flow ratios in liquidity measurement of the tobacco industry listed on IDX over five years period (2011-2015). The ratio used are four ratios of traditional ratios and four ratios of cash flow ratios in order to see differences of both ratios in liquidity measurement.
This research used tobacco industry listed on Indonesia Stock Exchange (IDX) in year 2015 as the object of the research. All four companies on tobacco industry listed on IDX were selected to be samples of research. Then analysis of data were processed by Microsoft Excel version 2013 and SPSS version 23.0 with using Mann Whitney U Test model to test the hypothesis.
The result of this research proved that there are significant differences between traditional ratios and cash flow ratios in liquidity measurement of tobacco company listed on IDX. The traditional ratios showed higher mean rank than cash flow ratios which indicates that traditional ratios of tobacco companies listed on IDX were better than the cash flow ratios. But, It is better to used both types of ratios. Traditional ratios and cash flow ratios is the complementary, so should be used together to reach a comprehensive conclusion about the liquidity position of the companies. Moreover, cash flow ratios are more effective measures because it give more information about the company's ability to meet its commitment.

Keywords: Liquidity analysis, Traditional ratios, Cash flow ratios, Tobacco industry Sector Listed on IDX


The present invention relates to a power transmission device for a washing machine, and an object thereof is to improve the assemblability and to simplify the structure. The present invention, dehydrated the stroke at the time of rotation so that rotation Joe, the top being coupled to the rotating tank and, de-shrinkage of the hollow shape extending from the lower portion of the bottom of the tank and; Is provided on the inside of the dewatering shaft, the top of the wash is combined with the rotor blades, in combination with the bottom of the motor shaft and; Connecting member to the laundry and the rotary axis is not be the de-shrinkage interlocked performing a dehydrating stroke, and so that the washing cycle is carried out be only the washing shaft is rotated, the connection or separation axis shaft and the washing and the dehydration; The connecting member and the elevating and rotating such that the de-contraction and the washing shaft connected to or be separated elevating, formed in the donut shape and the projection is projected outwardly lifting member; And the lift having a lifting guide hole which projections are accommodated in the member elevating guide portion, if not be guide to the elevation guide portion has the elevating member elevating rising by inhibiting the rotation of said coupling member to inhibit the rotation set of idle to make, in the connecting member and the power of the washing machine made of a fixing member formed with internal teeth which is engaged with the delivery apparatus; So as to reduce the number of parts guide the lift unit may be opened to lower the internal teeth of the outer of the fixing member is formed integrally with the fixing member.


Ⅰ. RADIAL EQUATIONFor the nuclear motion of a diatomic molecule, the radial equation, after separating the translational motion of the mass center and the angular part, can be written as


The invention comprises a releasing system (1) for a clutch and/or acceleration coupling (2) in a motor vehicle that automatically compensates any attrition on the clutch and/or acceleration coupling (2). The releasing system (1) consists of one piston-cylinder unit (24) arranged concentrically to an incoming gear shaft (12) which has one cylinder (13) and two pistons (14, 17) bordered by two pressure chambers (16, 19). The piston-cylinder unit (24) is controlled pneumatically and hydraulically.


Cryoglobulins are proteins that precipitate at temperatures lower than 37oC. The Brouet classification of cryoglobulinemia (CG) distinguishes three forms of CG by assessing the clonality of the cryoglobulin and its ability to bind rheumatoid factor (Brouet et al, 1974). Type-1 cryoglobulinemia (T1-CG) is defined by monoclonal proteins and suggests the presence of a lymphoproliferative disorder. These monoclonal proteins can form cold-induced aggregates, that in vivo may mediate inflammatory vasculitis (Lamprecht et al, 1999). Although, the term 'cryoglobulinemia' describes the presence of cryoglobulins in a patient's serum, from the clinical point of view this diagnosis often describes a vasculitis involving small vessels due to immune complexes. Cutaneous manifestations are present in most patients with T1-CG (Cohen et al, 1991). These symptoms are often observed many years before extracutaneous manifestations develop. In particularly aggressive cases, infarction, acrocyanosis, hemorrhagic crusts, Raynaud phenomenons and ulcers can occur. Exacerbation after cold exposure is common. Bortezomib (Velcade , Janssen-Cilag Pharma GmbH, Austria) is a selective proteasome inhibitor (Teicher et al, 1999) that has been approved for treatment of patients with multiple myeloma and mantle cell lymphoma (Richardson et al, 2003). In addition to its direct anti-tumour effects, anti-angiogenic actions of bortezomib have recently been described (Roccaro et al, 2006). Moreover, our group identified a protein named GRP-78 that confers resistance to the anti-angiogenic effect of bortezomib (Kern et al, 2009). To date there is only one short description of the efficacy of Bortezomib in a patient with T1-CG (Talamo et al, 2008). The present report describes a further two patients with a dramatic response of vasculitis associated with T1-CG, which was refractory to multiple treatment approaches. In June 2001, Patient 1, a 40-year-old male, presented at our Day Hospital because of vasculitis with positive cryoglobulins. The IgG level was 12Æ6 g/l. The peripheral blood count was normal. The serum creatinine was 1Æ10 mmol/l. A detailed diagnostic workup revealed no underlying haematological disease, no viral infection and a negative rheumatoid factor. A skin biopsy was performed, which revealed a vasculitis, and IgG protein complexes were detected by immunofluorescence. No monoclonal protein could be detected in the serum by immunofixation at this time. However, the positive immunofluorescence was suggestive for T1-CG, even with negative immunofixation. The patients' severe vasculitis was treated with prednisone (1 mg/kg) and cyclophosphamide (150 mg/d) and then methotrexate (15 mg/week). In June 2003 a paraprotein (IgG k) was firstly detected by serum immunofixation. The therapy was changed to azathioprine (200 mg/d) and prednisone due to uncontrolled vasculitis. A bone marrow biopsy was performed every year and in December 2007 a plasma cell count of 4% was described. However, fluorescence in situ hybridization (FISH) analysis of bone marrow identified for the first time chromosomal aberrations, such as del(13q14) and t(4;14). An off-label therapy with Rituximab (375 mg/m weekly for 4 weeks) was given from December 2007 to January 2008 without clinical improvement of vasculitis. In January 2009, bone-marrow examination revealed 10% plasma cells without a significant increase of the IgG amount in serum. Due to still uncontrolled vasculitis (Fig 1A), bortezomib was initiated at a dose of 1Æ3 mg/m on days 1,4, 8 and 11, resulting in a dramatic clinical response (Fig 1B) and azathioprine and corticosteroids could be suspended after the first


Activation of IL-2/15Rβγc or IL-7R on immune cells using modified versions of IL-2 or IL-7 is under investigation as monotherapy, or in combination with checkpoint inhibitors, engineered T or NK cells, or neo-antigen vaccines. We previously described small synthetic peptides, unrelated to IL-2, IL-15, or IL-7, that selectively activate either IL-2/15Rβγc or IL-7R. IL-2/15Rβγc and IL-7R activation exhibit complementary effects on immune cells that when combined may offer benefits over each independent mechanism. We now report the creation of an Fc-fusion protein that incorporates both IL-2/15Rβγc and IL-7R agonist peptides, and characterize its properties in cell lines and human (PBMC) lymphocyte subpopulations.Peptide agonists of IL-2/15Rβγc (MDK1169) and IL-7R (MDK1319) were separately fused to each chain of obligate heterodimeric (asymmetric) Fc molecules. The Fc-fusion was purified by protein-A and size exclusion chromatography, and characterized by LC-MS. Receptor-mediated signaling, proliferation, and cell-surface receptor expression in cell lines, PBMCs, mixed and isolated lymphocyte subpopulations were determined by flow cytometry and ELISA to evaluate effects of IL-2, IL-2v, IL-7, MDK-202 or MDK-701 (Fc-fusions of MDK1169 and MDK1319, respectively), and combinations (mixtures) of these molecules, in comparison with the dual agonist MDK-271.LC-MS analysis indicates MDK-271 is a heterodimeric molecule containing one copy each of MDK1169 (IL-2/15Rβγc-biased agonist) and MDK1319 (IL-7R agonist) fused to individual Fc-chains. Cell-based assay of MDK-271 demonstrates potent, fully efficacious phosphorylation of STAT5 in TF-1 cells expressing Rγc, and engineered to express either IL-2/15Rβ or IL-7Rα. PBMCs exposed ex vivo to MDK-271 exhibit additive, complementary, and synergistic effects among various lymphocyte subpopulations: CD4+Tn, Teff, Treg, Tmem; C8+Tn, Teff, Tmem; and NK cells, in this analysis. The mono-specific agonists MDK-202 and MDK-701 produce proliferative effects and signaling patterns in responsive cell lines and lymphocyte subsets similar to those induced by IL-2v (an IL-2/15Rβγc-biased mutant of IL-2) and IL-7, respectively. Combining both activities in MDK-271 induces response profiles that differ in some T-cell subsets from those of mono-specific agonists of the two receptors. Animal studies designed to understand the effects of these differences are underway.IL-2/15Rβγc and IL-7R are both currently undergoing extensive scrutiny as potential immuno-oncology therapeutic targets. The biology of these cytokines is both overlapping and complementary in stimulating and supporting T-cell populations; and some recent evidence suggests possible superiority of the combination. Based on in vitro properties, the Fc-peptide fusion reported here, exhibiting both IL-2/15Rβγc-biased agonist and Il-7Rαγc agonist activities, could be valuable in anti-tumor therapeutic applications.The use of human PBMC in this study was authorized under Minimal Risk Research Related Activities at Stanford Blood Center (SQL 79075)


Relationship issues and the 'pros and cons' of 'marriage counselling' enliven our airwaves and broadsheets. Kerry Bergin explores this phenomenon with media personalities Bettina Arndt and Julie McCrossin. (editor abstract)


This paper presents an application of thermography for aiding ITS in a nighttime-traffic evaluation. The mentioned evaluation is concerned on over limited velocity vehicles which are violating the driving laws, including security considerations. An utilized thermograph technique, in this research, for detecting and evaluating vehicles that are running with the over limited velocity is the consideration of colors¿ cluster underneath vehicles. The mentioned colors¿ cluster represents reflected heat between the road and vehicle. To implement such method for evaluating the velocity of vehicle, the movement of colors¿ cluster implicitly shows the velocity of vehicle. The average velocity of colors¿ cluster is able to be evaluated by finding the different positions of the cluster from consecutive image¿s frames and dividing by time interval. By means of utilizing such method, various average velocities of focused vehicles can be found, including not over and over limited speed. When implementing the mentioned method to sample thermal images which are recorded from a nighttime traffic road in Rangsit-Nakornayok area, it is found that 82.54 % accuracy occurred when inspecting on various type of vehicle comprises car, van, bus, and truck that running over the specified velocity.


In this study, the acoustic differences between the pointhead flounder and the juvenile walleye pollock were examined using a quantitative echo-sounder around the Funka Bay, Japan and the acoustic characteristics of the pointhead flounder have been surveyed. Acoustics data of the fish were monitored using a Simrad EK60 (38, 120, 200 kHz) split-beam echo sounder in the field. The target strength (TS) and swimming angle of free swimming pointhead flounders were measured in a seawater tank (length: 10 m, width: 5 m, and height: 6 m). As the result, pointhead flounder schools presented a patch shaped echo on the echograms, whereas the distribution patterns of the juvenile walleye pollock schools were layered. The volume backscattering strength (SV) of the target schools extracted from the echograms showed that the pointhead flounder presented a higher SV at high frequency. In contrast, the juvenile walleye pollock showed higher SV at a low frequency. For pointhead flounder, the distribution of pitch angle was measured both by camera and echo-sounder at the experiments in the tank and shown the same distribution pattern. The TS of pointhead flounder is large bigger than other bladderless fish.In this study, the acoustic differences between the pointhead flounder and the juvenile walleye pollock were examined using a quantitative echo-sounder around the Funka Bay, Japan and the acoustic characteristics of the pointhead flounder have been surveyed. Acoustics data of the fish were monitored using a Simrad EK60 (38, 120, 200 kHz) split-beam echo sounder in the field. The target strength (TS) and swimming angle of free swimming pointhead flounders were measured in a seawater tank (length: 10 m, width: 5 m, and height: 6 m). As the result, pointhead flounder schools presented a patch shaped echo on the echograms, whereas the distribution patterns of the juvenile walleye pollock schools were layered. The volume backscattering strength (SV) of the target schools extracted from the echograms showed that the pointhead flounder presented a higher SV at high frequency. In contrast, the juvenile walleye pollock showed higher SV at a low frequency. For pointhead flounder, the distribution of pitch angle was...


Article history: Received 14 June 2014 Received in revised form 5 September 2014 Accepted 6 September 2014 Available online 8 September 2014


The calanoid copepods Acartia tonsa and Eurytemora affinis were successfully cultured in two commercial synthetic sea salts. Success of a medium was measured by its ability to sustain a population of copepods that was subjected to moderate rates of harvest.


The use of large eddy simulation, or LES, to study the atmospheric boundary layer dates back to the early 1970s when Deardor (1972) used a three-dimensional simulation to determine velocity and temperature scales in the convective boundary layer. In 1974 he applied LES to the problem of mixing layer entrainment (Deardor 1974) and in 1980 to the cloud-topped boundary layer (Deardor 1980b). Since that time the LES approach has been applied to atmospheric boundary layer problems by numerous authors. While LES has been shown to be relatively robust for simple cases such as a clear, convective boundary layer (Mason 1989), simulation of the cloud-topped boundary layer has proved more of a challenge. The combination of small length scales and anisotropic turbulence coupled with cloud microphysics and radiation effects places a heavy burden on the turbulence model, especially in the cloud-top region. Consequently, over the past few decades considerable effort has been devoted to developing turbulence models that are better able to parameterize these processes. Much of this work has involved taking parameterizations developed for neutral boundary layers and deriving corrections to account for buoyancy effects associated with the background stratification and local buoyancy sources due to radiative and latent heat transfer within the cloud (see Lilly 1962; Deardor 1980a; Mason 1989; MacVean & Mason 1990, for example). In this paper we hope to contribute to this effort by presenting a number of turbulence models in which the model coefficients are calculated dynamically during the simulation rather than being prescribed a priori.


The challenge facing countries and regional bodies in the Asia and Pacific regions will be to determine the best way, collectively and individually, to develop the legislative and operational frameworks to effectively implement UNSCR 1540. A strategic and coordinated approach for the delivery of assistance programmes is important. In the author's view, the preferred approach is for assistance to be coordinated through regional organizations working with bodies such as the United Nations and potential donors on the development of regionally focused technical assistance programmes.


Objective To evaluate the influence of fosinopril on the left ventricular function and remodeling after AMI.Methods Thirty patients with acute myocardial infarction of anterior wall treated with fosinopril in 12 hours from the attack. The morphology of left ventricle and cardiac function (Killip methods) were assessed by 2DE at acute period and recovery period.Results Cardiac function and 2DE targets improved during 12 weeks follow-up in fosinopril group(P0.05).Conclusion Fosinopril for the patients of AMI without hemodynamics changes may significantly inhibit the ventricular dilatation and improve the cardiac function.


Two distinct interactions of Pomerons should occur in dense multi-string events. Besides the usual triple Pomeron processes transitions to membraned cylinders can be expected to contribute in a significant way. They offer an efficient mechanism for central baryon production and for the long range transport of initial baryons. The slope of such an exchange should be quite low as it is related to the Odderon known from the leading logarithmic approximation. Such a flat trajectory has to be suppressed by small coupling constants. It is argued that this strong suppression does not appear in diffractive events. In consequence there should be a tiny observable backward peak in the initial baryon distribution even in quite massive diffractive systems.


UNLABELLED
Urinary diversion after cystectomy in old and high risk patients is associated with major complications, exspecially those related to the type of urinary diversion. Ileal conduit and orthotopic bladder substitution have been the preferred option for urinary diversion after cystectomy. In patient with physiologic status classification determined by the American Society of Anesthesiologist (ASA) score, the complications related to the kind of diversion start to go up with ASA 3 patients. In patient ASA 3e, 4 and 4e ureterocutaneostomy represents a simplified choice for urinary diversion.

MATERIALS AND METHODS
At our department we performed 158 cystectomy from 2001 to 2005, 27 were female patient. In 5 (3.16%) patients ASA 4 and ASA 4e we choosed ureterocutaneostomy.

RESULTS
One patient died of myocardial infarction in intensive postoperative care unit and one patient had a serious stenosis of the ureter.

CONCLUSION
cutaneous ureterostomy after cystectomy may be indicated for patients ASA 3e, 4 and 4e. Operative risk is low. The first indication is for dilated ureters and not irradiated pelvis.


ABSTRACT The administration of Platelet Rich Plasma (PRP) is expected to be a supplement for treatment of diabetic wounds and hyperglycemia by increasing growth factors. The purpose of this study was to examine the effect of Platelet Rich Plasma (PRP) on the proliferation and viability of human dermal fibroblast (HDF) in high glucose conditions, as a model for healing diabetic wounds in vitro. HDF cells are grown in DMEM medium containing high glucose which are then with PRP. To measure the effect of PRP on the HDF cell proliferation, CCK-8 kit was used and evaluated by using a microplate reader. To evaluate the viability of HDF, an automated cell counter. The results of the research showed that PRP stimulate the HDF cells proliferation. The optimal dose of PRP to increase HDF cell proliferation is at dose of PRP 10%.  Supplementation of PRP is significantly increased cell viability and HDF cell counts within 48 hours. The results showed PDGF growth factor secreted by PRP is increased significantly. The conclusion is PRP stimulated HDF cell proliferation and viability in a high glucose condition. This finding support the used of PRP as a therapy for diabetic wounds. Keywords: proliferation, viability, human dermal fibroblast, platelet-rich plasma, diabetic


In this paper we apply the aspect-oriented programming (AOP) paradigm to Pig Latin, a dataflow language for cloud computing, used primarily for the analysis of massive data sets. Missing from Pig Latin is support for cross-cutting data concerns. Data, like code, has cross-cutting concerns such as versioning, privacy, and reliability. AOP techniques can be used to weave metadata around Pig data. The metadata imbues the data with additional semantics that must be observed in the evaluation of Pig Latin programs. In this paper we show how to modify Pig Latin to process data woven together with metadata. The data weaver is a layer that maps a Pig Latin program to an augmented Pig Latin program using Pig Latin templates or patterns. We also show how to model additional levels of advice, i.e., meta-metadata.


The modulation instability of the one-dimensional cubic-quintic complex Ginzburg-Landau equation with fouth-order dispersion and gain terms, a. k. a., the quintic complex Swift-Hohenberg equation, is investgated. The effects of the fourth-order terms to the modulational instability is studied. We numerically investigate the dynamics of the modulational instability in the presence of the fourthorder dispersion and gain terms. - PACS numbers: 42.65.Tg, 42.81DP, 42.65Sf


Introduction: the sirenomelia sequence is a primary defect that occurs in the mesoderm of the posterior middle axis of the embryo and turns out the fusion of the primordium of limbs in its fibular margins, with absence or complete development of the intercurrent caudal structures. Case report: a 36-year-old pregnant woman with a reproductive history of three previous pregnancies and two deliveries without abortions, who in the genetic risk assessment consultation, classified as increased genetic risk (risk of chromosomal alterations). A history of possible exposure to teratogens was collected. Multiple congenital defects were observed in the study of the fetus by means of ultrasound. Genetic counseling and reproductive options are provided in multidisciplinary team office to both members of the couple. Both gave their consent for the interruption of pregnancy . The pathological study confirmed multiple congenital anomalies. Conclusions: major congenital anomalies, that are part of the sirenomelia sequence, can be diagnosed in the prenatal stage by means of Ultrasonography Studies during the first and second trimesters of pregnancy. The definitive and classified diagnosis can be completed after the pathological study of the fetus.  Genetic counseling is improved and based on the consideration of the alterations in embryogenesis with its genetic and environmental aspects; where the concluding aspects are personalized considering the pregnant woman, her family, as well as her social and personal situation.


The main purpose of this study is to engage in research on a grid-connected photovoltaic (PV) power generation system smart inverter. The research content includes a smart maximum power point tracking (MPPT) controller and an inverter with power regulation. First, use the PSIM software package to establish the simulation environment of the grid-connected photovoltaic power generation system and use the Sanyo HIP-186BA19 photovoltaic module to form a 744 W system for simulation. In order to enable the photovoltaic module array (PVMA) to output the maximum power under different solar insolation and ambient temperature, the architecture is based on the extension theory-based smart MPPT method to improve the dynamic response and steady-state performance of photovoltaic power generation systems compared to perturb and observed (P&O) MPPT. When the sunshine is 1,000 W/m2, the photovoltaic power generation system adopts the extension theory-based maximum power tracking method. The time required to track the maximum power point is only 0.32 s, and the steady-state ripple is only 4.127 W. However, using the traditional P&O method requires 0.741 s to track the maximum power point, and the steady-state ripple reaches 18.131 W. Thus, the dynamic response speed of the maximum power tracking method proposed is 50% faster than that of the P&O method. The steady-state performance is also better compared to the P&O method. At the same time, a simple proportional-integral (PI) controller is used to regulate the DC-link voltage, output voltage, and current of the inverter to make the voltage of the grid-connected point stable at an effective value of 220 V. Then, the voltage-power control technology is added to the photovoltaic grid-connected inverter, and a simple proportional-integral controller is used to regulate the output of the smart inverter reactive power to improve the power quality of grid voltage. Finally, simulation and experimental results are used to verify the effectiveness of the regulation performance of the developed smart inverter.


Early and late complication of Bladder exstrophy surgery At Ribat University Hospital Pediatric Surgery Department 2006 -2012 in Sudan which showed very interesting result and promising result but need follow up study to the case in these poor population. Best type of procedure for these group of patient is different from one to other and from age to other, also depend on experience of surgeon which need to be assess in coming study.


Blast furnace cooling stave is an essential component for any steel manufacturing industry. It is used for maintaining the inner temperature profile and cooling of the refractory lining. The lifespan of any blast furnace depends on upon furnace cooling system. Therefore, it is important to monitor the internal thermal state of the blast furnace cooling stave. In this paper, a predictive model has been developed using heat transfer model and artificial neural network. Heat transfer model for cooling stave is modeled and analyzed using ANSYS software. A multi-layered neural network is developed to replace the unavoidable noise factor and to fill the deviation between a mathematical model of heat transfer and actual experimental data. All the data used for simulation and analysis purpose are obtained from Rourkela steel plant. The results of this predictive model are compared with the experimental data and result show the predicted value matches well with actual data. Its show the predictive model is effective.


The marine environment is characterized by existence of various small-scale inhomogeneities, which exist near the sea surface and in the water column: gas bubbles, different suspended matter, plankton of different sizes, microturbulence, etc. All of these reasons inhomogeneities add your contribution to the acoustic characteristics of the marine environment, including nonlinear characteristics which are important for hydroacoustics. Despite the importance of the nonlinearity parameter for the marine environment, information on measurement of it at sea is very scarce. In the paper features of linear and nonlinear acoustic characteristics of sea water containing small-scale heterogeneities are discussed. The results of studies of acoustic nonlinearity of sea water and the absorption of sound at different depths in situ are presented. A comparison are obtained for the local acoustic parameters and for coefficients of backscattering of sound in the upper ocean to a depth of 100 meters. It is shown that the acoustic characteristics change significantly with depth and the observed anomalies in absorption and nonlinearity due to the presence of heterogeneous inclusions. It is shown that peculiarities of the spatial structure of the scattering coefficient of sound due to changes in the structure of the bubble clouds entrained wind stress and induced currents at a wind speed of 12 m/s. It is discussed the relationship of scattering and absorption of sound with the acoustic nonlinearity of sea water. It is shown the ability to predict the distribution of acoustic nonlinearity and sound absorption in the ocean and in the shallow sea on the basis of remote sensing data for backscattering of sound.


The following paper introduces the function of reinforced concrete reservoir,illustrates its construction process and the construction elements and quality requirements of its main sub-item projects,and states the full water experiment of reservoir,which to offer a reference for similar construction.


Aiming at the die design of stamping part of junction plate for some electronic product,the die parts were integrated to realize multiple functions.In the bending station,the lifting pin was designed.To ensure the alignment accuracy of the upper and lower die,four precision ball guide columns were used.To ensure a gap between the stripper plate and the punch,the guide sleeve was added in the discharge plate.At the same time the die service life was extended.


Further lead optimization efforts on previously described 1,2,3,4,10,10a-hexahydro-1H-pyrazino[1,2-a]indoles led to the new class of 5,5a,6,7,8,9-hexahydro-pyrido[3 0,2 0:4,5]pyrrolo[1,2-a]pyrazines culminating in the discovery of (5aR,9R)-2-[(cyclopropylmethoxy)methyl]-5,5a,6,7,8,9-hexahydro-9-methyl-pyrido[3 0, 2 0:4,5]pyrrolo[1,2-a]pyrazine 18 as a potent, full 5-HT2C receptor agonist with an outstanding selectivity profile and excellent hERG and phospholipidosis properties. 2005 Elsevier Ltd. All rights reserved. Obesity is steadily increasing all over the world 1 and is a major risk factor in the development of hyperglycemia, hypertension, dyslipidemia, coronary artery disease, and certain cancers. The currently approved drugs for the long-term treatment of obesity are the appetite suppressant Sibutramine , a centrally acting mixed noradrenaline/ serotonin-reuptake inhibitor, and Xenical , a non-systemic acting lipase inhibitor which increases the fecal loss of undigested triglycerides. Recent evidence of the utility of 5-HT2C receptor agonists as appetite suppressants in the management of obesity has led to a resurgence of interest in selective and safe 5-HT2C receptor agonists. In preclinical studies, the involvement of the 5-HT2C receptor subtype in the control of feeding in animals 0960-894X/$ see front matter 2005 Elsevier Ltd. All rights reserved. doi:10.1016/j.bmcl.2005.11.083


SUMMARY This work analyzes the growth of Mexican research output and impact in the period 1980-2009. The general aim is to identify the policy issues that determined the consolidation of the scientific activity in Mexico during this period. The methodology employed is based on the use of tools such as the Web of Science, specifically the Science Citation Index and the Social Sci ence Citation Index, in addition to selected indexing services from various Mexican institutions. The findings confirm that sci entific growth came as the result of several changes associated with the number of active researchers in the National System of Researchers (SNI), fellowships for graduate studies, graduate programs certified by the National Council for Science and Technology (Conacyt) and implementation of the program of improvement of teachers in public universities, complemented with science policies performed efficiently by the Mexican government. The growth is independent of the stagnation of the federal spending in science and technology as percentage of the NGP. This conclusion is consistent with the thesis of other authors, that the growth of research in basic science is determined by a series of changes in the relevant scientific community.


High resolution aerogravity and aeromagnetic data were acquired in 2006 over a licence area in NE Libya. These data are compared with ground gravity and vintage magnetic data acquired in the 1960s and 1970s. The improvement with respect to the resolution of the tectonic features is discussed. The new data provided an excellent background for seismic survey planning. An area of about 30 x 80 km was covered with denser infill aerogravity lines (500 m line spacing). These data are investigated in order to test the improvement in resolution due to tighter line spacing as claimed by Sander et al., 2003.


We study = (2,2) supersymmetric abelian gauge theories in two dimensions. The exact BPS spectrum of these models is shown to coincide with the spectrum of massive hypermultiplets of certain = 2 supersymmetric gauge theories in four dimensions. A special case of these results involves a surprising connection between four-dimensional = 2 SQCD with N colours and N$>Nf>N flavours at the root of the baryonic Higgs branch and the supersymmetric CP2N−Nf−1 σ-model in two dimensions. This correspondence implies a new prediction for the strong-coupling spectrum of the four-dimensional theory.


The article contains the results of the experimental research on the identification of psychological particularities of young women descended from aggressive family environments, as well as the experiential personal development programme applied on those women. The effectiveness of the programme in personal development of women descended from aggressive family environments are demonstrated. As consequences of programme we consigned some changes: increasing the abilities to identify an aggressive environment, diminishing own aggression, optimizing personality by reducing negative affects and antagonism, developing resilience and self-esteem, improving emotional intelligence, well-being, decreasing depressive and anxious tendencies, diminishing stress and the reducing the level of detachment as sign of trauma.


Providing for the aged has become the social focus.It's historical choice that attracting and encouraging social capital into Old-age Services,innovativing the service mode.Based on cooperation,complementary advantages,risk-sharing,win-win benefit,PPP is public-private partnership model,the emphasis of which should be fixed on solving scientific and equivalent allocation between the risks and profits in the application process.The Shapley method based on risk-sharing better truly reflect the contributions of public and private,through comparing the profit allocation's efficiency under various modes,which also conducive to the realization of optimal total revenue and improving the level and quality of social communal services.


Fluorescence collectors (FSCs) offer the possibility to collect and concentrate direct and ambient light and are, thereby, an option to decrease the cost of high‐efficiency solar modules. So far, scattering, absorption and reabsorption of the incoming and fluorescence light cannot be discriminated completely in experiments. Thus, the contribution to the discrepancy of experimentally achieved efficiencies from the theoretical one has not been identified. To understand the propagation of the fluorescence light by illumination at a certain distance from the edge of the FSC, we have developed a two‐dimensional analytical model based on geometrical optics that reproduces the experimental results. Under certain conditions for each distance from the edge regimes of detection angles exist for which no fluorescence light of the edge occurs. Copyright © 2011 John Wiley & Sons, Ltd.


Technological scheme for the biological additional sewage cleaning has been offered. Reducing the concentration of nutrients in the wastewater to the required values provided by creating and maintaining optimal conditions for the aquatic phototrophic cultivation. An approach was presented allows us to calculate the main parameters of sewage post-treatment system on the example of higher aquatic plant.


A new coordination polymer, {[Mn(mip)(dps)](dpts)0.5}2n (1) (mip = 5-methylisophthalate) has been solvothermally synthesized by in situ generation of 4,4′-dipyridylsulfide (dps) and 4,4′-dipyridyltrisulfide (dpts) ligands from a 4,4′-dipyridyldisulfide (dpds) precursor. The coordination framework of 1 shows a new (3,5)-connected 3-D net topology with a Schlafli symbol of (42.65.83)(42.6), in which weak antiferromagnetic interactions are observed between the MnII ions.


Objective To evaluate the effects of remifentanil infusion on hemodynamics before CPB in children undergoing cardiac surgery.Methods Seventy-five children(1-12 years old) undergoing selective cardiac surgery were randomly allocated into 5 groups with 15 cases each.The patients in group F were injected fentanyl 10 μg/kg before skin incision after fentanyl 10 μg/kg injected for anesthesia induction.The patients in 4 remifentanil groups were given remifentanil infusion in the dose of 0.5(group R0.5),1.0(group R1.0),1.5(group R1.5)or 2.0(group R2.0)μg·kg-1·min-1 for the maintenance of anesthesia after a bolus injectionof 2 μg/kg for induction.Heart rate and mean artery pressure were recorded before induction(T0),at 2 min after intubation(T1),2 min after incision(T2),and 2 min after thoractomy(T3).At the same time,the frequency of metaraminol use was recorded before CPB.Results The hemodynamic parameters were generally stable at T0-T3 in all groups.Heart rate was higher in groups of R0.5 and R1.0 than that in group F(P0.05).The frequency of metaraminol use in group R2.0 significantly increased as high as 60%.Conclusion The hemodynamics can be kept stable by infusion of remifentanil 0.5-1.5 μg·kg-1·min-1 in children undergoing cardiac surgery.


In recent times, there has been much discussion reg arding the use of unsaturated soil mechanics for th e design of earth retaining structures in Adelaide's semi-arid condit ions. The soil-water characteristic curve (SWCC) is the main design tool within this field as a means to incorporate th additional shear strength associated with total s il suction. However, the majority of research to date only incorporates matric suction. This paper attempts to adopt the to tal suction profile to more effectively capture the behaviour of saline cl ays in Adelaide as osmotic suction is the dominant component of total suction. Furthermore, this research also cons ider clay soil behaviour, climatic effects over a 120 year period and identification of worst-case-scenarios in order to increase design efficiency. Previously published re sults were verified using the recently developed software SVOffice 2009 , created by SoilVision Systems Ltd. and an analysi s of the Millswood Underpass was conducted. This paper confi rms the relationship of total soil suction to stren gth of Adelaide clay known to design practitioners yet still not us ed in design. These results will pave the way for f urther research in order to improve the way retaining structures are b uilt on Adelaide clays.


This Technology Survey Report is comprised of reviewed and evaluated technical abstracts for about 100 significant documents relating primarily to life prediction for structural materials exposed to monotonic and cyclic loading, particularly in elevated temperature environments. The Introduction to the report includes an overview of the state-of-the-art represented in the documents that have been abstracted. The abstracts in the report are mostly for publications in the period April 1962 through April 1974. The purpose of this report is to provide, in quick reference form, a dependable source for current information on the subject field. It is a companion volume to NASA CR-134751, Life Prediction of Materials Exposed to Monotonic and Cyclic Loading - a Bibliography.


Since the first publication on proximal metatarsal V fractures by Jones in 1902,1 there has been a lot of controversy about the classification and ideal treatment of the proximal metatarsal V fracture. The controversy includes mainly the different anatomical,2,–,4 radiological5 and aetiological aspects.6,–,9 A proper understanding of these different aspects of the proximal metatarsal V fracture is essential, because a right interpretation of fracture type and the appropriate treatment strategy may greatly diminish the time to return to competitive sports or activities of daily living (ADL).

The purpose of this study was to evaluate the treatment strategies of the different proximal metatarsal V fractures (avulsion, Jones and stress fractures, figure 1) and their outcomes in athletes and non-athletes.

Figure 1
Anatomical locations of the different types of proximal fifth metatarsal fractures. The anatomic locations of the different types of proximal fifth metatarsal fractures are visualised in the grey-coloured areas. 1) Avulsion fracture (fracture of the tuberosity of the fifth metatarsal). 2) Jones fracture (border of metaphysis and diaphysis; fracture involving the intermetatarsal joint). 3) Stress fracture (fracture in the proximal diaphysis, distal from the intermetatarsal joint).

This evaluation is based on a critical overview of the current literature combined with the opinion of a group of international experts.

The hypothesis of this study is that operative treatment is the most effective treatment strategy for all proximal metatarsal V fractures, besides the non-displaced avulsion fracture.

### Literature overview

A literature search was performed covering …


In this paper, we extend PMON, a logic for reasoning about action and change, with causal rules which are used to specify the indirect effects of actions The extension, called PMON(RCs), has the ad ...


The influence of atmosphere (PO2=10−5–1 atm), temperature (T=810–890 °C) and time (6–60 h) on the formation of the Bi(Pb)2SrCa2Cu3O10 (110 K) phase in the Bi‐Pb‐Sr‐Ca‐Cu‐O high TC superconductor system of composition Bi:Pb:Sr::Ca:Cu=1.84:0.34:1.91:2.03:3.06 has been studied. The relationships between the fraction 110 K phase, heating atmosphere, temperature, and time have been mapped via experimental data.