DiGeorge syndrome is a genetic disorder that is related to a wide range of defects affecting various parts of the body. The clinical expression shows marked variability making the diagnosis often missed or underdiagnosed. Here, we describe a neonate who presented with loud inspiratory stridor secondary to hypocalcaemia at birth. Physical examination revealed no abnormality other than evidence of congenital cardiac defect. Laboratory evaluations confirmed the diagnosis of maternal vitamin D deficiency that led to symptomatic hypocalcaemia in the newborn infant. The presence of hypocalcaemia coupled with episodes of recurrent infections led to the clinical suspicion of DiGeorge, which was later confirmed by fluorescence in situ hybridisation test.


Abstract The aim of the article is to get to know the essence of production control in the activity of enterprises. This background presents: the role of control in the enterprise and its classification with particular emphasis on production control. Production control plays an important role in the proper course of the production process. On the one hand, it comes down to the preparation of production plans, creating cost budgets for the company's production parts, and on the other hand to control their implementation. In the scope of production control, economic control of production is taken into account, defined as a direct and indirect impact on the shape of the assortment- and quantity-related structure of production and its course in time and space to ensure, in the given circumstances, the best achievement of the organization's goals. Production control may refer to strategic planning, where the most important is to strike a balance between the flexibility of using production means and workforce, availability of technology and substitute technologies or operational planning, where the key task is to find and eliminate bottlenecks occurring in the production process.


The fracture of brittle solids is considered to be based on a defect configuration consisting of a stress concentrator, in our case a hemispherical pore, and a starter crack, in our case either a semicircular crack, a circular crack, or a circumferential crack. Computation of the stress field, application of the relevant weight functions, and an averaging scheme based on the assumption of a virtual crack increment provides stress intensity factors for all defect configurations considered. A normalization scheme yields a generalized version of the Orowan-Petch plot in the form of a normalized strength to normalized defect size relationship.


Objective: To investigate the effect of Huang Jin Fang in the prevention and treatment of influenza A H1N1 virus strain FM1 and strain PR8 infection in mice.Methods: Viral pneumonia was induced by intranasal infection with influenza virus in the normal and immunosuppressed mice.The mice were treated with Huang Jin Fang before and after infection,respectively.The changes in pulmonary index,mortality and life span of mice were compared among groups after medication.Results: Huang Jin Fang 3 and 6 g·kg-1 markedly decreased pulmonary index after infection in the normal mice compared with control group(P0.05),and all the doses(1.5,3 and 6 g·kg-1) significantly reduced mortality as well as prolonged survival time compared with infection control(P0.01).The doses of 3 and 6 g·kg-1 markedly decreased pulmonary index after infection in the immunosupressed mice compared with infection control(P0.05);significantly reduced mortality as well as prolonged survival time compared with infection control(P0.01).Conclusion: Huang Jin Fang has a remarkable effect in the treatment and prevention of influenza virus infection in mice.


The economic, environmental and social development should not degrade the environment but it should leave it for the next generations in the state that it is presently or even better. The principle of sustainable agriculture is to cover the human needs for food without damage to the environment. The aim of the article was to research the farmers' awareness of the principle of sustainable agriculture and balanced fertilization and their influence on the environment. Among 100 farmers of the Tczew district (Poland) there was done questionnaire research on the determination rates of nitrogen fertilizers and on the regulation of fertilizers usage in Poland. Most of farmers declared a good knowledge of good agricultural practices and of balanced fertilization and the awareness of threats issuing from their activities. At the same time in Poland since the announcement of the Nitrate Directive of the former European Common Market (1992) up till now (2013) the application of nitrogen fertilizers doubled and the yield of wheat increased only by 15%, which means the increase of environmental burden with this chemical element.


Abstract A collection of new oxypyridinium triflate reagents (1a–d) for the synthesis of halobenzyl ethers from alcohols under "mix‐and‐heat" conditions is described. The reagents are stable organic salts that can be stored indefinitely and handled without special precautions, making them attractive for general use in organic synthesis. Halobenzylation of representative alcohols occurs in good to excellent yield. This paper is dedicated to Professor Ken Goldsby (FSU) for his promotion and support of undergraduate research.


The literal believability of any photograph today can be called into question in view of the possibilities of computer manipulation. Was it ever so?This unique collection of photographs from the turn of the century shows how "retouchng" was used, even at the outset, to manipulate reality. Drawn from the Metz collection in Baden-Wurttemburg, the images come from the early postcard producer, Geler, and range across an astonishingly diverse field of subjects.Included are classic postcard scenes, but also the first soccer players, natives in Cameroon, folkfests in Southern Germany, zeppelins and much more. Over 200 photographs, based on the original large format glass negatives, show "manipulated" images from 1896-1920.This book is a must for students of the history of photography and connoisseurs of the genre.


Introduction. Total hip arthroplasty has become a successful way of treating the painful and destroyed hip joint in the patient with rheumatoid arthritis( RA). Materials and Methods. Two hundred and twenty (135 cemented and 85 uncemented) total hip arthroplasties were performed on 180 patients with rheumatoid arthritis. The average age was 48,61 years and the average follow-up was 8,4 years. Clinical evaluation was based on a Harris hip score that showed significant improvement in pain and function preoperatively, compared with pain and function at follow-up. There were two deep infections that required removal of the prosthesis. Four cemented acetabular cups and one cemented femoral component were revised due to aseptic loosening. Three acetabular rings were revised due to aseptic loosening. The relatively inferior results of total hip arthroplasty among RA patients are due not only to fixation method, but also to the poorer bone quality and weakening musculature. Conclusion. The results in these patients suggest that cementless total hip arthroplasty might become a successful way of treating the destroyed hip joint in the patient with rheumatoid arthritis.


An exploratory model of the stress process for dual-career women and men is presented and tested by path analysis. Distress, a global measure of somatic symptomatology, is the stress outcome measure. Results indicate that the men and women sampled are psychologically vested in both professional and family roles. Additionally, the women, all of whom are employed full-time, report no significant associations between having younger children and role strain, parental stress, or distress. Men who have a flexible work schedule indicate significantly lower marital, parental, and professional stress, as well as lower distress. Use of cognitive restructuring coping strategies was related to significantly lower distress for both genders; use of role reduction strategies was linked to higher distress levels for men. Additional findings reveal more differences than similarities by gender.


The MSME sector is a major source of growth in developing and transition economies. Despite their economic significance, MSMEs face a number of bottlenecks that prevent them from achieving their full potential. A major obstacle in MSME development is its inability to access timely and adequate finance. On the other hand, in recent years, there has been a significant increase in the incidence of default from the MSME sector. Hence, there is need to restructure the credit rating models used by banks for this sector.This study examines the factors affecting the credit-worthiness of borrowers from the MSME sector. The study uses discriminant analysis to identify significant factors that can be used to differentiate between defaulters and non-defaulters from the factors included in the credit rating model. This can help banks to identify factors that need special attention to reduce the risk of default. The analysis also highlights factors that should be considered for existing borrowers during annual as well as quarterly credit risk analysis, in order to identify existing borrowers vulnerable to turn NPA in the future.


The Biography of Yingying has much impact on later generations because of the beautiful image of Yingying. Yingying, as a female figure in legends in the Tang Dynasty, becomes a literary image of universal significance.


During its lifespan, a pavement will be travelled by many vehicles, of various types, which consume fuel, tyres, spare parts, etc. This means non renewable resources and energy consumption, as well as emissions to air (greenhouse effect gases and others). During the same period, the pavement will be subjected to maintenance operations (repairs and resurfacings), which also result in resource consumption and atmospheric emissions. It is thus possible to establish a balance adding up the consequences of the use of the road and of its maintenance. Moreover, the two terms are not independent, because the pavement maintenance improves the surface characteristics of the road, and hence decreases consumption related to its use. On the other hand, the road works may result in extra consumption and emission if the traffic is slowed down or diverted. The paper shows how the consideration for the balance makes it possible to define technical and strategic options for pavement maintenance, representing an optimum in order to decrease resource consumption and CO2 emissions (A). For the covering abstract of the conference see ITRD E212343.


Climate plays a significant role in shaping ecosystem-level carbon sinks. Research on the mechanisms of climate impacts on carbon sinks can contribute to the achievement of carbon neutrality. Investigating the mechanisms by which climate impact on carbon sinks in ecological spaces in the Beijing–Tianjin–Hebei region, one of the most important urban clusters in China, is of great significance. This study employed spatial autocorrelation and econometric models to explore how various climatic factors impact net primary productivity (which is used to represent carbon sink capacity) on a spatial scale. We found an increasing trend in NPP across the Beijing–Tianjin–Hebei urban agglomeration from 2000 to 2020, with marked spatial clustering. Climatic factors exhibited the best fit with the spatial Durbin model, except for average annual precipitation. The remaining factors had significant effects on NPP, showing spatial spillover effects. Results also showed that the average annual temperature, evaporation, and relative humidity had positive impacts on NPP at a local scale but adverse effects at a regional scale. Average annual sunshine duration and the ground temperature had negative effects on NPP locally but promoted effects regionally. Furthermore, the average annual wind speed negatively impacted both local- and regional-scale NPP. This research provides insights into how climate affects carbon sinks on a small spatial scale, offering important references for making policy decisions and improving the accuracy of carbon cycling simulations.


The compound (enH2)6[HV16IVV2VO42(Cl)]·Cl2·2H2O (en = 1,2-diaminoethane) (1), was synthesized under solvothermal conditions employing the amine as reducing agent. Compound 1 crystallizes in the orthorhombic space group Pbcn with a = 13.3343(7), b = 22.3697(3), c = 19.8012(11) A, V = 5906.4(5) A3, Z = 4. The central structural motif is a polyoxovanadate anion [HV18O42(Cl)]10– being composed of 18 VO5 square pyramids. The cluster shell contains a (VO5)8 ring in the vertical plane and two (VO5)5 pentagons above and below the ring which are twisted by 45° against each other.Bond valence sum analysis indicates a mixture of VIV/VV atoms with a ratio of 16:2, which is further supported by redox titration. An arrangement of these clusters within the (001) plane leads to the formation of channels hosting the protonated amine molecules, the Cl– anions and water molecules which are joined by an extended hydrogen bonding network. TG-MS investigation shows a thermal decomposition reaction in at least three steps. The optical band gap was determined as 2.5 eV.


Adding vertical ribs is recognized as a useful practice for reducing wind effects on cooling towers. However, ribs are rarely used on cooling towers in China since Chinese Codes are insufficient to support the design of rough-walled cooling towers, and an "understanding" hampers the use of ribs, which thinks that increased surface roughness has limited effects on the maximum internal forces that control the structural design. To this end, wind tunnel model tests in both uniform flow field with negligible free-stream turbulence and atmospheric boundary layer (ABL) turbulent flow field are carried out in this article to meticulously study and quantify the surface roughness effects on both static and dynamic wind loads for the purpose of improving Chinese Codes first. Subsequently, a further step is taken to obtain wind effects on a full-scale large cooling tower at a high Re, which are employed to validate the results obtained in the wind tunnel. Finally, the veracity of the model test results is discussed by investigating the Reynolds number (Re) effects on them. It has been proved that the model test results for atmospheric boundary layer flow field are all obtained in the range of Re-independence and the conclusions drawn from model tests and full-scale measurements basically agree, so most model test results presented in this article can be directly applied to the full-scale condition without corrections.


To create more vitality and sustainable cities, enhance quality of life for residents is the key issue of urban renewal. Multi-source data is main data source with ability of integration and analysis of data from multiple sources including POI, mobile phone signaling data, GPS track data, to better understand and improve the overall health and wellbeing of urban areas. In this paper, we proposed a framework of urban vitality estimation using mobile phone signaling data and POI data by combing Moran's I to determine the suitable analysis grid. As a result, the area of triangle made up of Old city, Baishahe, and Yangjiapu of Weifang city has a high degree of vitality, as it has both a diverse mix of land uses, and some concentration of land uses in certain areas.


Numerous studies in different countries find evidence for high rates of teacher turnover, leading to shortages and potential quality issues. Job satisfaction is found to be an important antecedent of turnover. In this study, we investigate the impact of various aspects of professional development for teachers (as well as interactions of these aspects) on job satisfaction. The main goal is to disentangle the interactions between need for and participation in professional development activities, allowing more detailed and precise analyses that may lead to a better substantiated understanding of the mechanisms at work. We use data from the 2018 wave of the OECD's Teaching and Learning International Survey (TALIS). The hierarchical data structure of teachers nested in schools, nested in regions requires the use of appropriate estimation techniques: multilevel or hierarchical linear modelling (HLM). We find a significant positive relationship between job satisfaction and need for professional development for teaching diversity and special needs, which is (negatively) moderated by the number of professional development activities a teacher had participated in. Another indicator, measuring the need for professional development in subject matter and pedagogy, shows a significant negative relationship with job satisfaction and is (positively) moderated by the amount of professional development.


This paper presents the performance analysis of space vector modulation control in seven level multi-string inverter. The seven level multi-string inverter is also used in industrial drives at various load condition. The output voltage and THD value of the various load condition is studied and it is tabulated below. The performance of five level and seven level multi-string inverter are compared and its output and THD values are tabulated below. To study the importance and advantage of space vector modulation control technique, the seven level multi-string inverter is implemented other PWM technique and its THD and output results are compared and tabulated below.


Principal Author's Biography Shalini Gupta received a BE degree in Electronics and Electrical Communication Engineering from Punjab Engineering College, India. She received a MS degree in Electrical and Computer Engineering from the University of Texas at Austin, where she is currently a PhD student. During her masters, she developed techniques for computer aided diagnosis of breast cancer. She is currently investigating techniques for 3D human face recognition.


Purpose
The purpose of this paper is to critically examine the prohibition on debt-to-equity conversions for private limited companies in Thailand, resulting from an interpretation of Section 1119 of the Thai Civil and Commercial Code (TCCC) adopted by academics and the regulator.

Design/methodology/approach
This paper critically examines the interpretation of Section 1119 of the TCCC made by academics, the Thai Supreme Court and the regulator. Taking an approach, which draws on debate in the EU over the past two decades, this paper presents a new understanding of the rules relating to legal capital in Thailand. This new understanding is applied to challenge the orthodox interpretation of Section 1119.

Findings
The interpretation proposed by this paper is that debt-to-equity conversions may be permitted when viewed as shares issued in return for payment in kind. This proposed interpretation is consistent with existing Thai Supreme Court jurisprudence. In addition, a close reading of the provision, further supported by a historical investigation into the legislative drafting process, reveals that it reflects the original intention behind this provision.

Originality/value
This paper presents a view of Thai legal capital rules, which challenges the orthodox understanding of their nature, purpose and categorisation. Furthermore, the proposed interpretation of Section 1119 of the TCCC, if adopted by the regulator, would permit Thai private limited companies to engage in debt-to-equity swaps without further legislative intervention.


Abstract The hornwort Notothylas orbicularis (Schwein.) Sull. is reported for the D. R. Congo and Uganda, new for Africa. It is characterized by bivalved capsules with strongly thickened exothecial cells, yellow spores and a minutely vermiculate spore wall. Earlier mentions of this taxon in Africa are based on the presence of N. decurva (Mitt.) Steph. This is also a yellow-spored species with vermiculate spore walls, but the capsules are indehiscent. It is not considered here as a synonym of N. orbicularis. Notothylas javanica (Sande Lac.) Gottsche is reported from the coastal zone of the D. R. Congo. It differs from N. decurva in the absence of pseudoelaters.


This research describes the effect of farm policy towards domestic investment and foreign investment in the province of Riau. Investment in the plantation sector in Riau province is part of the purpose of the investor as well as the geographic and regulatory support, global history of the emergence of the first foreign investment in Europe in 1760. The role of investment is helping the movement of the economy, then the researchers wanted to see Indonesia managing investments in domestic investment and foreign investment in the oil palm sector in the province of Riau. This research used a descriptive analytical method, in this study the data were compiled using data integration techniques Primary and secondary data. secondary data in the form of journals, mass media, books, research, Internet, and electronic media, the primary data used in this study in the form of data from agencies and legislation. Plantation policy and investment policy is a policy alignment reality in favor of investors. The lack of regulation in favor of the ruling capitalist society makes the system in the management of existing plantations in Indonesia, especially in the province of Riau. Keywords: plantation policy, domestic investment, foreign investment


The invention discloses an implementing device for precise data breakpoint in microprocessor and a method thereof. The device comprises a breakpoint configuring part, a breakpoint match judging part and a breakpoint triggering part, wherein, the breakpoint configuring part is used for preserving one piece or plural pieces of breakpoint configuring information, the breakpoint match judging part isused for judging whether a memory-reference instruction is matched with the breakpoint configuring information preserved in the breakpoint configuring part and preserving the judgment result in the state domain executed by the memory-reference instruction, and the breakpoint triggering part is used for checking the state domain of the memory-reference instruction, when the judgment result shows match, the normal executing state of the processor is suspended, and the processor enters into debug state. The manages breakpoint configuring information by adopting chart form, thus not only strengthening expansibility of breakpoint configuring capacity, but also causing breakpoint configuring to be more flexible. And precise data breakpoint can be effectively implemented by fine sorting breakpoint match success state and quasi breakpoint match success state under the condition that the processor flow line is hardly altered.


It is shown that in nonlinear discrete systems localized modes may exist in the form of self-induced gap solitons. Such structures appear due to a nonlinearity-induced gap in the cw spectrum, when one group of particles in the lattice plays a role of an effective periodic potential to other particles supporting a spatially localized oscillation. Two examples are considered and exact soliton solutions describing this type of localized modes are presented


The paper covers the sprinkler control system for dust suppression based on PAC technology.It composes of GE Fanuc PACSystem RX3i and Easy View touch screen and has functions of automatic,manual and timing sprinkling,and trouble signal and failure alarm.Actual running shows that it is reliable and efficient.


OBJECTIVE
To provide right time points in selection of right aged animals and the normal physiological data of TX mice.

METHODS
7-12 months old TX and DL mice were studied, each group contained 3 female and 3 male mice of TX or DL mice. The concentration of copper in the serum, dry tissues (liver, brain and kidney), together with copper biochemistry indexes were measured. The liver histopathology was observed under light microscopy and electron microscope.

RESULTS
Transaminase increased significantly only in 10 and 11-month- old (AST(TX10) = 218.3 U/L, AST(TX11) = 197.5 U/L, AST(DL10) = 171.5 U/L, AST(DL11) = 165.0 U/L, P(10) less than 0.001, P(11) = 0.022), but the copper concentration of liver, brain and kidney was significantly increased during 7-12 month old (the average concentration of copper, Liver(TX) = (750.0 +/- 85.5) mg/kg, Brain(TX) = (39.7 +/- 2.2)mg/kg, Kidney(TX) = (29.8 +/- 5.0) mg/kg, Liver(DL) = (11.6 +/- 1.5) mg/kg, Brain(DL) = (16.8 +/- 0.9) mg/kg, Kidney(DL) = (14.2 +/- 1.0) mg/kg, t = 21.16, 23.60, 7.47, for all these organs P less than 0.05).

CONCLUSION
TX mice is a suitable model of liver disease with natural recovery, so selecting animal model of suitable time point is very important.


'Influence of subclinical generalized spike-wave activity on the heart rate of children with epilepsy' SIR–Seizure activity may lead to changes in heart rate and rhythm and even to sudden unexpected death in epilepsy (SUDEP), as it is well known in adults. The pathomechanisms of SUDEP are not yet fully understood and in children with epilepsy, the influence of epileptic potentials on cardiac activity has been given little attention. The present study compared echocardiograms (ECGs) during periods where the simultaneously recorded electroencephalograms (EEGs) showed generalized subclinical spike-wave activity (GSSWA) with ECGs recorded during periods where the EEG showed no GSSWA. We investigated generalized subclinical SWA in children for the following reasons. We focused on SWA that was generalized, as it is well known that ECG abnormalities occur more often during generalized seizures and we hypothesized that this form of epilepsy might lead to a 'stronger' involvement of central cardiac control centres. Furthermore, we used the criterion that the SWA had to be subclinical, as we hypothesized that factors such as psychological or emotional stress, or the mere muscular activity induced by seizures which may influence the heart rate are negligible. This study is of an observational nature. We analyzed retrospective EEGs. GSSWA was defined as an EEG seizure pattern that was not associated with any disturbance of sensory phenomena, motor function, or consciousness in the awake children. We analyzed 117 EEGs and detected 14 episodes of GSSWA in nine patients (five females, four males; mean age 9y [SD 3y 6mo]; range 5y 8mo–16y 4mo). The children were clinically healthy without any other neurological problems or syndromes. A diagnosis of epilepsy in the children was based on International League Against Epilepsy classification: five children had absence epilepsy and four children had tonic–clonic seizures. A standard EEG was recorded over 20 minutes according to the international 10 to 20 system. Simultaneous to EEG recordings, paper ECGs were obtained by one limb lead. To determine the heart rate we counted the R-waves from the paper ECGs and extrapolated the values to beats per minute. We only considered EEGs with GSSWA that did not occur under photostimulation and/or hyperventilation. Therefore, analysis periods became short. We determined three different measuring times: (1) Control: we computed the mean heart rate (beats/min) out of three traces of 10 consecutive RR-intervals before and after the onset of GSSWA; (2) Before GSSWA: we counted the mean heart rate out of three traces of 10 consecutive RRintervals directly before the onset of GSSWA; and (3) During GSSWA: we measured the heart rate during GSSWA, when a minimum three artefact free RR-intervals were measurable during GSSWA. For all considered EEGs and times we computed the means [SDs], medians, and ranges for heart rate in beats/minute: (1) Control: baseline heart rate (mean 90.5 [SD 11.5]; median 89.9; range 70.8–118.2); (2) Before GSSWA: heart rate directly before onset (mean 90.3 [SD 11.8]; median 91.5; range 75.3–118); and (3) During GSSWA: heart rate during GSSWA (mean 90.8 [SD 14.8]; median 93.0; range 66.6–112.5). No significant difference (p>0.05) of the heart rates was detected for any one of the time intervals related to GSSWA. Limitations of the study were the small sample size and the short duration of the GSSWA and RR analysis periods. To our knowledge this is the first study of the influence of GSSWA on the heart rate of children with generalized epilepsy. We failed to detect any significant changes in heart rate in this group. O'Regan et al.1 studied 37 children with focal, generalized, and absence epilepsy during clinical seizure activity to observe changes in cardiac and respiratory function. They described an increase in heart rate of 26% in focal seizures and a decrease of 48% in generalized seizures. These results are difficult to discuss in relation to our results as we studied subclinical SWA. It has been suggested that cardiac arrhythmia during or before seizure onset could be a possible cause of SUDEP in adults with temporal lobe epilepsy. A 'malfunction of the central cardiovascular system' has also been suggested,2,3 but the exact mechanisms are not known. In adults, focal seizure activity may trigger cardiac arrhythmia by an involvement of the insular cortex.4 We studied GSSWA involving both hemispheres simultaneously. Although the seizure generation is different in absence epilepsy and generalized tonic–clonic seizures, both seizure forms directly or indirectly affect central cardiovascular control centres in both hemispheres. The simultaneous involvement of both hemispheres in generalized epilepsy might explain the fact that we did not observe any changes in heart rate due to GSSWA.


Breathing abnormalities are a common non‐motor symptom (NMS) of Parkinson's Disease (PD), and multiple causes have been proposed, including impaired central respiratory control. While the loss of dopaminergic neurons is the primary pathology of PD, it is becoming better appreciated that serotonergic (5‐HT) dysfunction also plays a role in the development of motor and NMS and complications in PD. To this end, recent studies addressing the role of 5‐HT in PD symptoms have revealed that activation or antagonism of specific 5‐HT receptor subtypes may have therapeutic benefit. 5‐HT neurotransmission is also known to play a critical role in control of breathing; thus, respiratory abnormalities in PD may be further complicated by the progressive 5‐HT dysfunction in PD. Ongoing work in our laboratory has been focused on characterizing the respiratory phenotype of PD using 6‐hydroxydopamine (6‐OHDA) neurotoxin‐induced preclinical rat models of PD. Here, we evaluate potential contributions of 5‐HT dysfunction by assessing the effects of acute administration of the selective 5‐HT reuptake inhibitor fluoxetine hydrochloride (FLX) on basal inspiratory motor (diaphragm EMG) activity and hypoxic (HVR) and hypercapnic (HCVR) ventilatory responses in spontaneously breathing urethane‐anesthetized adult female rats 2‐weeks after unilateral medial forebrain bundle (MFB) 6‐OHDA or vehicle/control injection. Basal (BL) diaphragm EMG activity was recorded for ≥30 min, the HVR (12% O2, 90s) and HCVR (7% CO2, 5 min) were assessed, acute FLX (10 mg/kg, iv) was injected and allowed 30 min to exert steady‐state effects, and then the HVR and HCVR were re‐assessed. We found that in both vehicle‐ and 6‐OHDA‐injected rats, administration of FLX produced an initial increase in burst frequency (by ~30%) and amplitude (by ~15%) above BL levels within ~60 s, after which burst frequency attenuated to a new steady‐state level of ~10% above BL levels while burst amplitude returned to slightly below BL levels in vehicle‐injected rats, but attained a new steady‐state level of ~10% above BL levels in 6‐OHDA‐injected rats. The effects of FLX on HVR and HCVR frequency behaviors were negligible in both control‐ and 6‐OHDA‐injected rats although a slight attenuation of the HVR frequency increase (by ~5%) was seen. The effects of FLX on HVR and HCVR amplitude behaviors, while underpowered, showed a trend of slightly enhanced of HVR amplitude (by ~5%) and HCVR amplitude (by ~9%) in 6‐OHDA‐injected rats; however, additional experiments are needed to determine the significance of these observations. While these preliminary observations suggest that (compared to control rats) MFB‐lesioned rats exhibit a difference in FLX‐induced effects on basal inspiratory burst amplitude alterations, acute FLX administration may not be able to fully correct chemical control of breathing deficits. We suggest that additional experiments are needed to better identify specific 5‐HT mechanisms that may contribute to chemical control of breathing deficits in this PD rat model.


In the article the problems of international relations between the USSR and the USA in 1945-1953 are discussed. This period marks the beginning of the Cold War. In the postwar period the bipolar system developed in international relations. Relations between the USSR and the USA two antagonistic systems in this period are characterized as political, ideological, economic and local military confrontation.


Traditional functionalist approaches to autism consider cognition, communication, and perception separately, and can only provide piecemeal accounts of autism. Basing an integrative explanation on a single cause or common factor has proven difficult. Traditional theories are also disembodied and methodologically individualistic. In order to overcome these problems, I propose an enactive account of autism. For the enactive approach to cognition embodiment, interaction, and personal experience are central to understanding mind and subjectivity. Enaction defines cognition as sense-making: the way cognitive agents meaningfully connect with their world, based on their needs and goals as self-organizing, self-maintaining, embodied agents. In the social realm, when we interactively coordinate our embodied sense-making, we participate in each other's sense-making. Thus, social understanding is defined as participatory sense-making. Applying the concepts of enaction to autism, I propose that 1) Sensorimotor particularities in autism translate into a different sense-making and vice versa. Autistic behaviors, e.g. restricted interests, will have sensorimotor correlates, as well as specific significance for autistic people in their context. 2) Socially, a reduced flexibility in interactional coordination can lead to difficulties in participatory sense-making. At the same time, however, seemingly irrelevant autistic behavior can be quite attuned to the interactive context. I illustrate this complexity in the case of echolalia. An enactive account of autism starts from the embodiment, experience, and social interactions of autistic people. Enaction brings together the cognitive, social, experiential, and affective aspects of autism in a coherent framework based on a complex, non-linear multi-causality. On this foundation, bridges can be built between autistic people and their often non-autistic context, and quality of life prospects can be improved.


Few mathematical operations are more important to the engineer than convolution and transform analysis. In this article, the operation of convolution is explored-starting with discrete rather than continuous convolution because of the relative ease of comprehension involved. With this foundation, the study is extended to continuous convolution. A proof of the convolution theorem will show that convolution and transform analysis are closely related. Of much more interest, however, is an intuitive explanation of why convolution and transform analysis techniques lead to exactly the same solution of a given problem. Perhaps the two most important applications of convolution deal with the analysis of linear systems and the sums of independent random variables-the latter problem being used to introduce discrete convolution.


The utility model relates to the technical field of detection equipment and in particular to a glass dimension detector. The glass dimension detector comprises a frame which is provided with a transparent detection platform, an industrial computer, a display, a CCD measurement module located below the detection platform, and a shading plate located above the detection platform, wherein the display and the CCD measurement module are electrically connected with the industrial computer respectively, the detection platform is provided with a plurality of positioning blocks used for supporting a piece of glass, and the CCD measurement module consists of a plurality of CCD image sensors. During detection, the CCD measurement module can automatically detect length, width, hole diameter, hole roundness, symmetry, position and the like of a piece of glass and display the dimension information on the display once the glass is placed on the positioning blocks. The glass dimension detector is high in detection precision, simple in structure and low in cost; an operator can quickly and simply detect whether all dimensions of a piece of glass meet the standards with the detector; the detection efficiency is high; and the working intensity is low.


The seedballs of introduced 51 Hippeastrum vittatum varieties were planted in the greenhouse without heating in winter in Guangzhou, and artificial pollination, bearing fruit, and seedling were further investigated. The survey revealed that, seeds could be obtained by self-pollination of 29 varieties or hybridization among 309 combinations. In total, 621 ripened fruits and 35 114 full seeds were harvested through self-pollination and crossbreeding. Furthermore, 18 045 seedlings were obtained by breeding in pot, with a seedlings productivity of 51.4%. In addition, we also found that genotype had great effect on the percentage of seeding and seedling.


We present a block lower triangular (BLT) preconditioner to accelerate the convergence of nthe Krylov subspace iterative methods, such as generalized minimal residual (GMRES), for solving a broad class of complex symmetric system of linear equations. We analyze the eigenvalues distribution of preconditioned coefficient matrix. Numerical experiments are given to demonstrate the effectiveness of the BLT preconditioner.


In this paper, I present a study I conducted in the University of Athens on the reflective orientation of teacher education and the ways student teachers interpreted it. The paper consists of three parts. The first part presents the theoretical framework of the course: action research and the reflective model of teacher education. The second part attempts to roughly describe the course, focusing on the parameters governing its reflective perspective: it is an investigation of the student teachers' beliefs, tacit knowledge on teaching and awareness of their influence on their decisions in practice. The third part presents the results of the analysis of student teachers' journals, that confirmed the dynamics developed through the interaction of student teachers both in research groups and in the plenary meetings, where views could be exchanged and questions supported the development of a reflective practice. However, it also revealed the limitations and dysfunctions of this effort, mainly due to the dominant culture of technical rationality, which was only slightly changed by the way the course was organised.


Genetic sequencing of diffuse intrinsic pontine gliomas (DIPG) has revealed genomic heterogeneity, sparking an interest in individualized and targeted treatment options for this particularly devastating disease. A feasibility study, PNOC003: Molecular Profiling for Individualized Treatment Plan for DIPG (NCT02274987), was completed within the Pacific Pediatric Neuro-Oncology Consortium. In this study, a multidisciplinary tumor board reviewed detailed molecular and genomic profiling of each participant's tumor and made molecularly-targeted treatment recommendations. Separately, our team developed the Central Nervous System Targeted Agent Prediction (CNS-TAP) tool, which combines pre-clinical, clinical, and CNS penetration data with patient-specific genomic information to derive numeric scores for targeted anticancer agents, aimed to objectively evaluate these therapies for use in patients with CNS tumors. We hypothesized that highly-scored agents within CNS-TAP would overlap with the agents recommended by the tumor board in PNOC003. For each study participant, we used the genomic profiling report to identify actionable alterations and incorporated these data into CNS-TAP to identify the highest-scoring agents. We compared high-scoring agents within CNS-TAP with recommendations from the tumor board for each of the enrolled 28 participants. Overall, 93% of patients (26/28) had at least one agent recommended by both the tumor board and CNS-TAP. Additionally, 38% of all agents (36/95) recommended by the tumor board were also selected by CNS-TAP. We identified factors that likely contributed to the differences in therapy recommendations between these two methods: CNS-TAP requires additional clinician input to account for drug-drug interactions, includes only classically-defined anticancer agents, and cannot easily be updated in real-time as new data emerge. However, CNS-TAP provides an objective evaluation of targeted therapies, whereas tumor boards are inherently subjective. A prospective study incorporating both CNS-TAP and a molecular tumor board for targeted therapy selection in high-grade glioma is currently ongoing to further compare and objectively evaluate these methods.


I propose a parsimonious Gaussian Ane Term Structure Model (GATSM) to reconcile empirical ndings that while the level, slope and curvature (or the rst three principal components of yields) can quite accurately describe the cross-section of yields, dierent linear combinations of interest rates and other macro variables are useful to predict excess returns. I introduce a forecasting factor, which compactly summarizes rich information in expected excess returns, to a conventional three-factor (the level, slope and curvature) GATSM. This fourth factor is constructed by reduced rank forecasting regression with a large predictor set, and it can explain one-year excess returns of two- to ve-year maturity bonds from 1964 to 2007 with R 2 up to 0.71. Considering the fact that the forecasting factor and the rst three principal components span the cross-section of expected excess returns and that of yields, respectively, I restrict parameters of the four-factor GATSM. In contrast with the conventional three-factor GATSM, the restricted four-factor GATSM generates plausible countercyclical term premia.


This research aims to predict the water level using deep-learning algorithm. To achieve this goal, we applied the TensorFlow, a deep-learning open source library to predict the water level of Okcheon station in the Guem-river. For model training and prediction, two hourly water level data sets of th...


— In this paper the Similarity Index variability range is investigated. Depending on the recognition rates of abstract-level classifiers, the lower and upper bounds of the of the Similarity Index variability range is theoretically analysed. The experimental tests, carried out in the field of handwritten numeral classification, confirm the theoretical findings.


The role of urodynamics (UDS) before surgery for stress urinary incontinence (SUI) remains a debated issue in female urology as well as in urogynaecology and it has been recently questioned on the basis of data coming from selected population of patients defined as "uncomplicated." The aim of this study was to investigate the percentage of "uncomplicated" patients undergoing urodynamic evaluations in six referral Italian centers. The secondary aim was to assess the prevalence of women, for whom the urodynamic evaluation could add new information to the pre‐urodynamic picture and in how many cases these findings had a significant impact on patient management.


Objective
To investigate the effects of quercetin on glial scar formation and axonal regeneration after spinal cord injury (SCI) and its association with the p38 mitogen activated protein kinase (MAPK) signal pathway.

Methods
128 female Sprague-Dawley (SD) rats were randomly divided into a control group (SCI + saline), an intervention group (SCI + quercetin + anisomycin), a treatment group (SCI + quercetin) and a sham-operation group (n=32). Basso Beattie Bresnahan (BBB) assessment and footprint analysis of the hind limb were performed on days 1, 3, 7, 14, 21 and 28 postoperation in each group. The expression levels of p38MAPK, phosphorylation p38MAPK, glial fibrillary acidic protein (GFAP) and neurofilament protein-200 (NF-200) were detected by Western blot. The numbers of GFAP and NF-200 positive staining cells in the injured spinal cord in each group were detected by immunohisto-chemistry.

Results
The BBB scores in the treatment group were significantly higher than in the inter-vention and control groups at each time point after SCI except on day 3 postoperation (P 0.05). The numbers of NF-200 and GFAP positive staining cells were significantly greater than in the sham-operation group at each time point postoperation (P< 0.05); the NF-200 positive staining cells in the treatment group were significantly increased in comparison with the control and intervention groups (P< 0.05); the GFAP positive staining cells in the treatment group were significantly fewer than in the control and intervention groups on days 7, 14 and 28 postoperation (P< 0.05).

Conclusions
Quercetin may have protective effects against acute SCI by decreasing glial scar formation, increasing axonal regeneration and promoting recovery of locomotor and nerve function in rats. The effects may be correlated with inhibition of the p38MAPK signal pathway.

Key words:
Spinal cord injury; Quercetin; Glial fibrillary acidic protein; neurofilament protein-200; p38 mitogen activated protein kinase


Appetite suppression induced by amphetamine has been attributed to its inhibition of neuropeptide Y (NPY) neurons and activation of pro‐opiomelanocortin (POMC) neurons in the hypothalamus. This study examined whether STAT3 was involved in these actions of amphetamine.


The present work is aimed to carry out the effect of geopolymer material which is fly ash as filler in the glass reinforced epoxy pipe on the micro structure of fly ash geopolymer, compression properties, and bulk density using the filament winding method. Conventional glass reinforced epoxy pipes has its own disadvantages such as high corrosion resistance at acidic environment and low strength which can be replaced by the composite pipes. Geopolymer is a type of amorphous alumino-silicate and can be synthesized by geopolymerization process. A series of glass reinforced epoxy pipe and glass reinforced epoxy pipe filled with 10 - 40 weight percentage geopolymer filler which is fly ash with 4 Molarity were prepared. Morphology of the raw material fly ash and fly ash based-geopolymer surface was characterized using scanning electron microscopy. It was found that the additions of fly ash at the beginning with 10 wt% are showing higher compressive strength than glass reinforced epoxy pipe without fly ash geopolymer filler. The compressive test of these series of samples was determined using Instron Universal Testing under compression mode. It was found that compressive strength for samples fly ash based-geopolymer filler are higher as compared to glass reinforced epoxy pipe without geopolymer filler. However, the compressive strength of glass reinforced epoxy pipe with fly ash geopolymer filler continues to decline when added to 20 wt% - 40 wt% of geopolymer filler loading. The results showed that the mixing of geopolymer materials in epoxy system can be obtained in this study.


Long Term Evolution (LTE) is the improvement of the 3G W-CDMA system and offers higher system capacity while being more robust against multipath fading. For this purpose it features several multiple antenna schemes. Receive diversity is a mandatory multiple antenna scheme. This paper proposes an architecture for receive diversity which significantly reduces the power consumption compared to conventional approaches. Depending on the environment it has a similar performance as maximum ratio combining while delivering a power saving of 30% in the radio frontend and allowing even better power reduction on system level. Minor modifications have to be made at the radio frontend. The performance of the proposed architecture is evaluated in multipath fading channels in terms of bit error rates.


Avian influenza is a contagious disease of birds in worldwide,which can be greatly devastating for the poultry (industry) and become the biggest menace to this industry. Furthermore avian influenza virus can directly (infect) humen and cause their death, which makes serious risks to human health. In this avticle,we introduce the pathogen, gene structure of avian influenza virus and its pathogenesis and damage to poultry and human, discuss the host response,humoral immune response and cellular immunity, and summarize the features of avian influenza virus for further research.


In this work, a AlGaN/GaN based High Electron Mobility Transistor with 3 μm gate length is designed and simulated with the Silvaco TCAD software which is passivated by SiO2. A drain current of 658 mA/mm is found for a gate voltage of 2.5 V. The transconductance of the device is 123 mS/mm at the gate voltage of 2V. A maximum output conductance of 163 mS/mm is obtained at the drain voltage of 45 V. The gate to source and gate to drain capacitance is calculated for the device. The cutoff frequency of the device is 2.6 GHz and the maximum frequency oscillation of the device is 9.8 GHz. A minimum noise figure of 11.6 dB is obtained at the operating frequency 5 GHz. Intrinsic time delay of the device is 122 ps. These properties prove that the AlGaN/GaN based HEMT is perfect for high power applications as well as microwave applications.


Objective Capecitabine is an oral 5-fluorouracil (5-FU) pro-drug commonly used to treat colorectal carcinoma and other tumours. About 35% of patients experience dose-limiting toxicity. The few proven genetic biomarkers of 5-FU toxicity are rare variants and polymorphisms, respectively, at candidate loci dihydropyrimidine dehydrogenase (DPYD) and thymidylate synthase (TYMS). Design We investigated 1456 polymorphisms and rare coding variants near 25 candidate 5-FU pathway genes in 968 UK patients from the QUASAR2 clinical trial. Results We identified the first common DPYD polymorphisms to be consistently associated with capecitabine toxicity, rs12132152 (toxicity allele frequency (TAF)=0.031, OR=3.83, p=4.31×10−6) and rs12022243 (TAF=0.196, OR=1.69, p=2.55×10−5). rs12132152 was particularly strongly associated with hand-foot syndrome (OR=6.1, p=3.6×10−8). The rs12132152 and rs12022243 associations were independent of each other and of previously reported DPYD toxicity variants. Next-generation sequencing additionally identified rare DPYD variant p.Ala551Thr in one patient with severe toxicity. Using functional predictions and published data, we assigned p.Ala551Thr as causal for toxicity. We found that polymorphism rs2612091, which lies within an intron of ENOSF1, was also associated with capecitabine toxicity (TAF=0.532, OR=1.59, p=5.28×10−6). ENSOF1 is adjacent to TYMS and there is a poorly characterised regulatory interaction between the two genes/proteins. Unexpectedly, rs2612091 fully explained the previously reported associations between capecitabine toxicity and the supposedly functional TYMS variants, 5′VNTR 2R/3R and 3′UTR 6 bp ins-del. rs2612091 genotypes were, moreover, consistently associated with ENOSF1 mRNA levels, but not with TYMS expression. Conclusions DPYD harbours rare and common capecitabine toxicity variants. The toxicity polymorphism in the TYMS region may actually act through ENOSF1.


We develop a price competition model for a new supply chain that competes in a market comprised of some rival supply chains. The new supply chain has one risk-neutral manufacturer and one risk-averse retailer in which the manufacturer is a leader and retailer is a follower. The manufacturer pays a fraction of the risk cost (caused by demand uncertainty) to the retailer. We apply this competitive model to a real-world case in a supply chain under uncertain environment and obtain the optimal wholesale and retail prices. We show that our obtained prices are better than the existing wholesale and retail prices and admit more profits for both manufacturer and retailer and generally for the entire supply chain. Also, using this case, the effects of risk sensitivity of retailer and fraction of risk cost shared by manufacturer in the total risk cost on the new supply chain's optimal wholesale and retail prices and profits are illustrated.


By the end of the nineteenth century,Morgan pr op osed a classic evolutionary pattern of primitive society.However,Morgan's patter n has been proven to be erroneous by the new achievements of ethnology today.Fi rst,clans did not evolve from Blood Family.Second,tribes were not the organizati on of blood relationship.Third,tribe leagues were not of universal significance. Finally,Greek was not the typical early State.Today we should eliminate Morgan's error,and prove the Marxism's theory of the states' origination by the new achi evement of modern anthropology.


The invention provides a remote real-time system for assets management of air conditioning equipment, which can be applied to a network system so as to carry out the real-time networking monitoring management work of assets to the air conditioning equipment at the distant end; the remote real-time system for assets management of the air conditioning equipment is characterized in that the real-time monitoring management to the running state of the air conditioning equipment under control can realize the remote monitoring function to the air conditioning equipment assets, thus achieving the objective of saving the operation cost.


The manufacture of parts via fused deposition modelling (FDM) is inhibited by a lack of understanding of the manufacturing process, resulting in parts having unreliable mechanical properties. Correspondingly, this paper considers the incorporation of capability profiles (CPs) for FDM as a solution. The evolved requirements of CPs for FDM are considered and the necessary process information that would be incorporated within them is presented. A review of existing literature of the effect of process parameters on mechanical properties of FDM parts identifies process variability and the effects of shape and scale as areas insufficiently studied. To address this, tensile tests are conducted revealing: 1) variation (26%) in identical test specimens' UTS; 2) that properties do not scale linearly with specimen size; 3) that cross-sectional shape directly impacts mechanical performance. These results are used to define the parameters required for a capability profile for FDM and subsequently demonstrate its functionality.


By the methods of literature study,questionnaire,teaching experiment and statistics,an experimental study on motivation teaching mode was carried out among the 120 students randomly selected in Shanghai Institute of Foreign Trade.A questionnaire on the recognition of motivation teaching mode was also conducted in the experiment group.The result shows that motivation teaching mode meets the demands of the college students in learning tennis and inspires their motivation of learning.The teaching process brings the students' intelligence to full play and improves their cognitive ability.It may realize the objective of students'self-study and accelerate the achievement of the teaching targets.The college students have high recognition toward the motivation teaching mode in tennis teaching.


Radiation characteristics of a wide-band dipole antenna over an electromagnetic band-gap (EBG) reflector are investigated. The mushroom-like EBG structure is used as the EBG reflector. The analysis is performed using Method of Moment. It is shown that wideband characteristics of the voltage standing wave ratio (VSWR) are obtained. However, good radiation patterns in the wide frequency range are not always obtained even though the wideband EBG reflector is used. Subsequently, the radiation mechanism is analyzed. The analysis results show that the shape of the radiation pattern depends on the dimension of the EBG patch.


If the male seed is not strong enough for impregnation, this weakness can be compensated by medical intervention in (parts of) the female body. If something in the unborn child is not quite right, this can be diagnosed and occasionally even surgically repaired—again by means of intervention in the female body. Paradoxically, now that women have achieved an unprecedented level of emancipation and autonomy, and their life fulfillment no longer exclusively lies in the (re)production of husband and child, the advent of new technologies such as in vitro fertilization (IVF), prenatal diagnostics, and fetal surgery leads to an increasing subjection of women to medical treatment for the benefit of others. What has been acquired via the political and social front door—independence, relative freedom, right of self-determination—seems to slip away again through the medical-technological backdoor. The woman, reduced to a manipulable body, may once more cushion the problems of men and children. I probably formulate it less diplomatically than she does, but this issue, with its strong political connotations, is the main theme of van der Ploeg's dissertation, Prosthetic Bodies. The Construction of the Fetus and the Couple As Patients in Reproductive Technologies. Even in the more empirical chapters, one consistently senses this normative commitment. But van der Ploeg never relapses into a politically correct vocabulary about the oppression of women by the power of male physicians. On the contrary, van der Ploeg shies away from such classical sociological formulations in terms of professional authority and medicalization. She does not reject the medicaltechnical world but, rather, embraces it by carefully reconstructing the shifts that have


Based on the analysis about the proportioning optimization and prodiction model applied with BP neural network,a static control system for converter has been established for 50 t converter used in a plant,which comprised with some modules as the proportioning optimization,the static pridiction,process control,deoxidation and alloying,and cost calculation. The porportioning optimization module has been established on mechanical modle,and used to calculate the burden sturcture for converter. The static pridiction model has been set up on BP neural network to pridicting the endpoint carbon content in liquid steel and its temperature. The process control model has been constructed with operating experiences to provide lance level curve,the charging time and the feeding quantities. The deoxidation and alloying model has been set up on endpoint pridiction and total oxygen content module to provide the quantities of deoxidant and alloys. The cost calculation model has been established on process control and static pridcition. The static control system could provide real-time and direct guidance for operater through the proportion optimization and static control model.


The objective of experiment was to study on pysiological and yield of different fertilization systems on flag-leaf resistance of winter wheat Intercorpped pepper,and to provide scientific basis for fertilization and utilization efficiency of aricultural waste resource. Using cattle manure as basic fertilizer and overwintering top dressing under field condition,The content change of chlorophyll,net photosynthetic rate, soluble protein, SOD and MDA of winter wheat leaf were explored.The results showed that in conditions of increasing application of cattle manure and decreasing fertilizer application rate, treating organic fertilizer as basic fertilizer,basic fertilizer and top dressing before overwintering,and top dressing before overwintering,which could promote the synthesis of chlorophyll and soluble protein, at the same time it could effectively regulate the decrease of SOD activitiy and content of MDA,as well as effective control or postpone the senescence process of winter wheat, therefore,could extended leaf function period.Based on the three treatments,the accumulation of the photosynthetic substances could be increased.Among which using before overwintering had better effects, 29.97%higher yield than that of control.


The treaty of peace, concluded at Paris, between the United States and Spain, December 10, 1898, provided, in Article VII, as follows: The United States and Spain mutually relinquish all claims for indemnity, national and individual, of every kind, of either Government or of its citizens or subjects, against the other Government that may have arisen since the beginning of the late insurrection in Cuba, and prior to the exchange of ratifications of the present treaty, including all claims for indemnity for the cost of the war. The United States will adjudicate and settle the claims of its citizens against Spain relinquished in this article.


Under a rapidly changing market environment, most companies are striving to survive in such environment. Organizational members have a positive impact on performance if they are properly rewarded and respected. This study aims to understand the causal relationship between leadership and organizational fairness and psychological empowerment. We also wanted to understand the impact of organizational fairness and psychological empowerment on job performance. To do this, we conducted surveys on workers. Results of this study shows that leadership has a positive impact on organizational fairness and psychological empowerment. In addition, psychological empowerment was found to have a positive impact on job performance, however, organizational fairness was found to have no effects on job performance.


A numerical and experimental study of multiple circular synthetic jets interacting with low Reynolds number laminar channel flow is presented. Flow velocity and temperature fields in channel are computed using three-dimensional computational model under a meso-scale. The working fluid is air. Moreover, flow visualization in water is performed under approximately double size. The computed flow field and heat transfer distribution on the wall are compared with the experimental results.


While current NL2SQL tasks constructed using Foundation Models have achieved commendable results, their direct application to Natural Language to Graph Query Language (NL2GQL) tasks poses challenges due to the significant differences between GQL and SQL expressions, as well as the numerous types of GQL. Our extensive experiments reveal that in NL2GQL tasks, larger Foundation Models demonstrate superior cross-schema generalization abilities, while smaller Foundation Models struggle to improve their GQL generation capabilities through fine-tuning. However, after fine-tuning, smaller models exhibit better intent comprehension and higher grammatical accuracy. Diverging from rule-based and slot-filling techniques, we introduce R3-NL2GQL, which employs both smaller and larger Foundation Models as reranker, rewriter and refiner. The approach harnesses the comprehension ability of smaller models for information reranker and rewriter, and the exceptional generalization and generation capabilities of larger models to transform input natural language queries and code structure schema into any form of GQLs. Recognizing the lack of established datasets in this nascent domain, we have created a bilingual dataset derived from graph database documentation and some open-source Knowledge Graphs (KGs). We tested our approach on this dataset and the experimental results showed that delivers promising performance and robustness.Our code and dataset is available at https://github.com/zhiqix/NL2GQL


In this essay, Professor Wasserman discusses the First Amendment implications of recent controversies over offensive and profane cheering speech at college sporting events. Use of offensive chants and signs by student fans has prompted several universities, most notably the University of Maryland, to consider establishing fan codes of conduct at stadiums, in the stated interest of protecting the sensibilities of unwilling captive listeners at the game, especially children. The First Amendment, particularly Cohen v. California and the protection accorded to the manner of communicating a message, renders such speech policies invalid at public university stadiums and arenas. Arenas are forums for what can be labeled "cheering speech," protected expression by fans about the game, the participants, and the surrounding circumstances. This essay is part of a broader upcoming project on the free speech rights of fans at public sporting events and the link between free expression and professional sports in American society and popular culture.


Objective:To explore the curative effect of trimetazidine in the treatment of coronary heart disease with cardiac failure.Methods:121 cases of patients with coronary heart disease and cardiac failure were randomly divided into experimen tal group(n=63) and control group(n=58) from February 2006 to April 2009 in hospital for treatment.Both groups were given routine treatment,and experimental group were added to trimetazidine therapy on base of control group.Results:The total effective rate of experimental group was 70.7%(41/58),excellent rate was 46.6%(27/58),the data of control group was 95.2%(60/63) and 61.9%(39/63),it showed significant difference(P0.05).The LVEDD,LVESD and LVEF in two groups showed significant difference,too,the clinical effect of experimental group were significantly better than that of control group(P0.05).Conclusion:trimetazidine combined with routine therapy used in coronary disease with cardiac failure patients can significantly enhance clinical effect and improve the life quality of patients,so it deserves application and pro motion in clinical work.


In this work we introduce a generalized linear model regulating the spread of population displayed in a \begin{document}$ d $\end{document} -dimensional spatial region \begin{document}$ \Omega $\end{document} of \begin{document}$ \mathbb{R}^{d} $\end{document} constituted by two juxtaposed habitats having a common interface \begin{document}$ \Gamma $\end{document} . This model is described by an operator \begin{document}$ \mathcal{L} $\end{document} of fourth order combining the Laplace and Biharmonic operators under some natural boundary and transmission conditions. We then invert explicitly this operator in \begin{document}$ L^{p} $\end{document} -spaces using the \begin{document}$ H^{\infty } $\end{document} -calculus and the Dore-Venni sums theory. This main result will lead us in a later work to study the nature of the semigroup generated by \begin{document}$ \mathcal{L} $\end{document} which is important for the study of the complete nonlinear generalized diffusion equation associated to it.


The business practices of financial institutions have evolved dramatically during the past two decade. Personal selling has been the key channel by which the financial product are made available to the customer. Salespeople play an important role in communicating with the customers and build strong relationship and have a strategic impact on organizations. Finding in the sales literature indicate that Customer orientation has a significant impact on sales performance. In the context of consultative selling, higher customer orientation on the part of the sales people can lead to mutually beneficial relational outcomes also. Customer orientation is found to increases customer loyalty with interactionoriented buyers, strong brands, and individualized products (Homburg, Müller and Klarmann, 2011). The authors feel that an over emphasis on CO may result in lower sales outcomes for sales person especially in financial products were uncertainty is high and financial loss may be in the offing. The study was carried out among sales people in the Banking and Financial Service Institutions. Empirical evidence reveals that, while customer orientation has a U-shaped relationship with sales performance but a linear and positive relationship with relational outcome.


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A spray reagent is described, based on the Guyard reaction between MnII and MnVII ions. It is useful after paper electrophoresis of carbohydrates, polyhydroxy compounds, hydroxy acids and unsaturated compounds.


Glass tubes that are coated on their inside surfaces with a semiconducting metallic oxide, and that have a potential difference of 1 or 2 kv between their ends, are used as continuous-dynode electron multipliers. An electron entering one end of the tube strikes the oxide coating and releases secondary electrons, which drift down the tube before striking the tube wall again. The gain and noise characteristics of this type of electron multiplier are described. (T.F.H.)


The introductory chapter focuses on a detailed survey of Hemingway criticism starting from Young and Baker to the present times, thereby revealing how the role and significance of Hemingway women have been neglected or misread. The chapter also discusses the twenties, the most significant decade of the 21 st century which witnessed the changing face of America and Europe. As a result of World War and its after effects the whole western history was being split in to the old and the new, separating the past from the present. There was a clear rise of a new generation disenchanted with the orthodox and conventional world and anxious experience life on their own. It was also the time in the Anglo-American history when the new woman was emerging on the social scene. The rise of new woman was a distinguishing feature of this decade and it is best reflected in Hemingway's fiction. Hemingway's women, the leading ones, belong to the new, young generation, distinctly different from the orthodox older generation. Through his woman characters, Hemingway has always held his ground firmly against the orthodox and conventional world and tried to understand and showcase the changing social fabric of his era.


Given a sequence of n real numbers a1,a2,a3,...,an, the maximum segment sum problem is that of determin- ing indices i and j (1 � ijn) such that the sum s(i,j) = ai + ai+1 + ... + aj is a maximum. Monotone matrices were shown to be remarkably effective in solv- ing several geometric optimization problems. The sur- prise is that it can also be applied to the above problem as we show here. Recently, there was a breakthrough in obtaining an O(nlogn) algorithm for the kth smallest segment sum problem by exploiting a connection of this problem to the well-known slope selection problem. In this paper we show that this problem can also be solved within the same time bounds in the simpler framework of expander graphs.


The utility model discloses a pressure-monitoring femoral artery hemostat which is composed of a bottom shim plate 1, an inflation ball 2 and a pressure gauge 3, wherein the edge of the outer side of the bottom shim plate 1 is provided with a vertical fixing rod 4. The vertical fixing rod 4 is sheathed with a lifting slide block 5 provided with a transverse square hole; a transverse support rod 6 is inserted into the transverse square hole of the lifting slide block 5, and the inner end of the transverse support rod 6 is fixedly provided with a cylinder 7; a piston is arranged in the cylinder 7; the lower end of a piston rod 8 connected with the piston is fixedly provided with a rubber compression head 9. The pressure meter 3 is arranged on the upper end of the cylinder 7, and an air inlet of the upper end of the cylinder 7 is connected with the inflation ball 2 by a guide pipe 10. The pressure-monitoring femoral artery hemostat has the advantage of simple structure, and the pressure can be regulated in time under the condition that the pressing pressure is observed in time; the positioning of the pressing position of the utility model is stable, the operation is fast and the work efficiency and the pressing and the hemostasis effects can be improved.


Since its inception in ancient Greece, the clinical method has experienced no major changes in its components and application. However, for some time now, it has been infringed upon by the high impact of technology on the healthcare sciences, and the new paradigms imposed on clinical practice and medical education. This article describes the most relevant historical data on the clinical method, its scientific components and its application in medicine, highlighting its importance in all medical aspects; and provides some thoughts on the reasons for this crisis and how it involves general medical practitioners in Colombia. (Acta Med Colomb 2021; 46. DOI: https://doi.org/10.36104/ amc.2021.1997).


Amachan was shown as a serialised morning drama on Japan's Nippon Hōsō Kyōkai (NHK) network between April and September 2013. New episodes played 6 days a week, with each instalment running 15 minutes. The combination of the long-form presentation and nearly day-to-day presence helped to integrate the drama into the daily lives of its viewers, and its narrative emphasis on family relationships, experiences shared across generations and nostalgic representation of 1980s popular culture imbued Amachan with a heavy dose of intimate sentimentality. This article will analyse the myriad of ways that Amachan entertains the possibility for public and private forms of media intimacy, focusing on questions of the temporality of broadcast formats, nostalgic representation of 'old' media and personal copies and celebration of television-centric models of celebrity.


In this paper, we respond to Gozlan's views of the introduction of freshwater fish, as we strongly disagree with his view and approach. We demonstrate that many realworld examples of freshwater fish introductions have catastrophic ecological consequences. We detail a few noteworthy examples, such as those of the Nile perch, carp, tilapias, catfishes, and the zebra mussel. We discuss within-nation


It is noted that the high instrumental accuracy of modern marine spectrophotometers for reflectance measurements is difficult to implement due to large methodological errors caused by the sea surface waves by weather conditions and illumination geometry. A two-beam spectrophotometer based on the use of a multi-channel photomultiplier eliminating the disadvantages is proposed. The design and operation principle of a spectrophotometer, developed on the basis of a compact high-aperture monochromator and a photometric unit, in which the channels of the upwelling radiation and the irradiance of the sea surface are located, are described. In the instrument, instead of absolute measurements, the light fluxes are compared in a differential photometer instead of absolute measurements in order to reduce methodological errors. The use of a differential photometer, which measures the spectral reflectance of water, can significantly increase the measurement accuracy, because does not require absolute calibration of optical channels. The use of a multichannel photomultiplier leads to an additional decrease in methodological errors by reducing the time of measurements of the seawater spectral reflectance and makes it possible to select a sufficient number of spectra in a large volume of data without interference from waves and lighting conditions. The photomultiplier signals are digitized using a compact USB ADC/DAC module with digital input/output functions. Amplified signals from photocathodes are received at the module input, the module output is connected to the USB input of a computer recording signals and controlling the spectrophotometer work.


The relationship between unemployment and pay has recently been encapsulated in terms of a "wage curve" whereby increasing unemployment acts to curb the general level of pay; see Blanchflower and Oswald (1990) hereafter BO. Results from BO, and elsewhere, allude to the possibility of an upturn in the curve with the level of pay tending to rise as unemployment passes some critical rate. BO attribute the upturn observed in their study to a data aberration, claiming that such a finding "... appears to go against commensense".' The shape of the wage curve has important policy implications and although the empirical evidence for an upturn is relatively weak, such a possibility should not be dismissed a priori. The aim of this note is to stimulate further research into the nature of the wage curve by deriving sufficient conditions for an upturn from a formal model. The idea is to supplement the standard neo-classical model of the wage curve with behavioural assumptions drawn from the social-psychology literature.2 The note concentrates in particular on the concept of "status". Workers are assumed to be primarily, but not exclusively, concerned with the monetary rewards to an occupation. The status associated with a particular occupation plays a significant role in their decision making.


Using the previously developed method for calculating crystal properties based on the Mie–Lennard-Jones pair potential, the thermodynamic properties of the BCC and FCC phases of iron at the temperature of the polymorphic BCC-FCC phase transition are calculated. 23 properties of iron and their changes during the BCC-FCC transition are calculated. Calculations have shown that properties such as the Gruneisen parameter, the coefficient of thermal expansion, and the heat capacity practically do not change during the BCC-FCC transition. The elastic modulus, specific entropy, Poisson's ratio, and specific surface energy change in the same way as the molar volume, i.e. within 1%. The Debye temperature and its pressure derivative decrease at the BCC-FCC transition in the same way as the distance between the centers of the nearest atoms increases, i.e. within 2-3%. Based on the analysis of experimental data known from the literature, it is shown that even relatively accurately measured parameters such as the coefficient of thermal expansion and elastic modulus are measured with an error exceeding the values of jumps in these parameters at the BCC-FCC transition. It is indicated that amorphization or nanostructuring of a certain portion of iron during the BCC-FCC transition can contribute to changes in the properties of iron during this phase transition.


The results obtained using Cuban human recombinant alpha erythropoietin, ior-EPOCIM, at the Institute of Nephrology, Havana, are presented. From June 1999 to June 2001, 143 hemodialysis patients with renal anemia were treated during a minimum of four months with initial subcutaneous 30 U/Kg dosage. Results: 88% of the patients met criteria for satisfactory response, hematocrit rising from 22.1% to 33.1%. The average weekly dosage of EPOCIM, individually adjusted to maintain a target hematocrit of no less than 33%, ranged from 87 to 105 U/Kg. The number of transfused patients was reduced from 94.4% before treatment to less than 24.5% at the end of the study. The only complication detected was transient arterial pressure increase, not associated with other complications and not requiring interruption of r-HuEPO use. In short, ior-EPOCIM showed results similar to other international commercial r-HuEPO for improving and correcting renal anemia. As a result of this research, progressive national extension of the product was begun, free of charge to all patients in hemodialysis.


Shape memory alloys possess several features that make them interesting for industrial applications. However, due to their complex and thermo-mechanically coupled behavior, direct use of shape memory alloys in engineering construction is problematic. There is thus a demand for tools to achieve realistic, predictive simulations that are numerically robust when computing complex, coupled load states, are fast enough to calculate geometries of industrial interest, and yield realistic and reliable results without the use of fitting curves. In this paper a new and numerically fast material model for shape memory alloys is presented. It is based solely on energetic quantities, which thus creates a quite universal approach. In the beginning, a short derivation is given before it is demonstrated how this model can be easily calibrated by means of tension tests. Then, several examples of engineering applications under mechanical and thermal loads are presented to demonstrate the numerical stability and high computation speed of the model.


Objective: To recommend the new concept of cervical cancer diagnosis and management in hospital by evaluating the efficacy of different screening methods. Methods: The clinical data and samples of 155 women were collected and analysis in Xiangya Hospital of Central South Universityfrom January 2018 to May 2020. Liquid based cytology (LBC), high-risk HPV, and TruScreen (TS01) were used to evaluate the effectiveness.The positive rate, sensitivity and specificity of cytology, hrHPV, colposcopy, and TS01 were calculated at the CIN2+ cut off point of pathological results. Results: The positive result of TS01 in normal, CIN1, CIN2 and CIN3+ lesions, the positive rates of TS01 were 23.3%, 63.4%, 80.0%, and 85.7% respectively. The positive rate of hrHPV, cytology, and colposcopy at CIN2 and worse were 100%, 79.2%, and 95.8%. The positive rate of hrHPV and cytology with inflammation and normal cervix pathologic results were 75.6% and 46.7%, respectively. The gynecological department of Xiangya Hospital set up a new patient management process during the COVID-19 pandemic, the closedloop disease monitor and treatment management system has done the great effect during COVID-19 pandemic period. Conclusion: The new cervical cancer screening and follow-up management concept to reduce the coronavirus infection and precision therapy by the optical and electrical instrument (TruScreen) and the closed-loop disease monitor and treatment management system was study and recommended in the study.


A hybrid-flash memory device and a reserved block assigning method thereof are provided to assign reserved blocks in the hybrid-flash memory device mixing single-bit flash memories and multi-bit flash memories by considering characteristics of the mixed flash memories, and relieve a bad block generated in the single-bit and multi-bit flash memories efficiently by variably managing the restricted reserved blocks. A main array includes a first main area and a second main area of which the number of bits stored in each cell is bigger than the first main array. A hidden area includes a first reserved block area(136) comprising a plurality of first memory blocks of which the number of bits stored in each cell is equal to the first main area and a second memory block area(137) comprising a plurality of second memory blocks of which the number of bits stored in each cell is equal to the second main area. A flash translation layer substitutes a bad block generated in the first main area with the first memory block and substitutes the bad block generated in the second main area with the second memory block. The flash translation layer assigns a function of the first and second memory blocks flexibly according to exhaustion of the first and second memory block.


Reviews a century of radio metrology research and development in the US that paralleled the birth and evolution of radio/wireless and other electromagnetic technologies. The interplay between the scientific and technological advances and the research, measurement and standards development programs at the National Institute of Standards and Technology (formerly the National Bureau of Standards (NBS)) was a factor that facilitated both commercialization of products and implementation of systems for the public benefit.


In the present paper, a generalization of the first part of the Borel-Cantelli lemma is obtained by the recent work of Balakrishnan and Stepanov (2010). This generalization is further applied to derive strong limit results for the sequence of maxima.


The paper shows how a corpus-based approach can be used to investigate the development of vocabulary diversity during the school years. The theoretical and pedagogical motivations for the investigation are outlined and advantages of using a corpus-based approach are discussed. The problem of the text-length effects on typetoken ratios is presented, followed by a description of a recent mathematical solution to the problem (Richards and Malvern, 1997). Data for the investigation consisted of a corpus of 899 narrative essays from school children aged 8 to 15. The essays were grouped into three three age categories (Key Stages 1, 2 and 3) and within each Key Stage, essays were further categorised according to a maximum of eight possible levels of writing ability as defined by the British National Curriculum for English. An analysis was carried out for each Key Stage to determine the relationship between level of linguistic ability and vocabulary diversity. The paper presents results from the analysis and discusses some theoretical and pedagogical implications. Future applications of the mathematical model to the investigation of diversity in categories of linguistic form other than vocabulary are discussed.


We consider the impact of isospin violation on the analysis of K-> pi pi decays. We scrutinize, in particular, the phenomenological role played by the additional weak amplitude, of |Delta I|=5/2 in character, incurred by the presence of isospin violation. We show that Watson's theorem is appropriate in O(m_d-m_u), so that the inferred pi-pi phase shift at sqrt{s}=m_K determines the strong phase difference between the I=0 and I=2 amplitudes in K-> pi pi decay. We find the magnitude of the |Delta I|=5/2 amplitude thus implied by the empirical branching ratios to be larger than expected from estimates of isospin-violating strong and electromagnetic effects. We effect a new determination of the octet and 27-plet coupling constants with strong-interaction isospin violation and with electromagnetic effects, as computed by Cirigliano, Donoghue, and Golowich, and find that we are unable to resolve the difficulty. Exploring the role of |Delta I|=5/2 transitions in the CP-violating observable epsilon'/epsilon, we determine that the presence of a |Delta I|=5/2 amplitude impacts the empirical determination of omega, the ratio of the real parts of the |Delta I|=3/2 to |Delta I|=1/2 amplitudes, and that it generates a decrease in the estimation of epsilon'/epsilon.


Particles suspended in a fluid flow through a curved duct can focus to specific locations within the duct cross-section. This particle focusing is a result of a balance between two dominant forces acting on the particle: (i) the inertial lift force arising from small but non-negligible inertia of the fluid, and (ii) the secondary drag force due to the crosssectional vortices induced by the curvature of the duct. By adopting a simplified particle dynamics model developed by Ha et al. [2], we investigate both analytically and numerically, the particle equilibria and their bifurcations when a small particle is suspended in low-flow-rate fluid flow through a curved duct having a 2× 1 and a 1× 2 rectangular cross-section. In certain parameter regimes of the model, we analytically obtain the particle equilibria and deduce their stability, while for other parameter regimes, we numerically calculate the particle equilibria and stability. Moreover, we observe a number of different bifurcations in particle equilibria such as saddle-node, pitchfork and Hopf, as the model parameters are varied. These results may aid in the design of inertial microfluidic devices aimed at particle separation by size.


This paper presents the development of an ultra-precision stage control system by introducing the nonresonant ultrasonic motor (NRUSM). System identification experiments are carried out considering the fundamental characteristic of NRUSM. The friction, which affects the accuracy of the positioning, is evaluated. Then the relation between the friction and the control bandwidth is experimentally examined. Using the frictional property as well as the identified model, the position control system with friction compensation is designed. Moreover, for its design the anti-windup-based wide band control is performed. Thus, the effectiveness of the identified model and the designed control system is verified by simulations and experiments.


Background

Angiogenesis is a critical step in pancreatic neuroendocrine tumour (PNET) growth and may be a selective target for PNET therapy. However, PNET is robustly resistant to current antiangiogenic therapies which primarily target the VEGFR pathway. Thus, PNET angiogenesis mechanism was urgently to be clarified.
Methods

Dataset analysis was used to identify PNET angiogenesis related genes. Immunohistochemistry was performed to determine relation among Neuropilin 2 (NRP2), VEGFR2 and CD31. Cell proliferation, wound-healing and tube formation assay were investigated to clarify the function of NRP2 in angiogenesis. The mechanism involved in NRP2 inducing angiogenesis was detected by mutant construction, Western blot, and immunofluorescence assay. In vivo, mice model was performed to evaluate the effect of NRP2 antibody, and clinical data was recruited to verify association between NRP2 and patients prognosis.
Results

NRP2, a VEGFR2 co-receptor, positively correlated with vascularity rather than with VEGFR2 in PNET tissues. NRP2 promoted PNET cell medium-treated HUVEC cell migration via a VEGF/VEGFR2-independent pathway. Moreover, NRP2 induced F-actin polymerization by activating the actin-binding protein cofilin. Mechanistically, cofilin phosphatase slingshot-1 (SSH1) was highly expressed involved in NRP2-activating cofilin. Silencing SSH1 rescued NRP2-activated HUVEC cell migration and F-actin polymerization. Furthermore, blocking NRP2 in vivo suppressed PNET angiogenesis and tumour growth. High NRP2 expression was associated with poor prognosis in PNET patients.
Conclusion

Vascular NRP2 promotes PNET angiogenesis via activating SSH1/cofilin/actin axis. Our findings demonstrate NRP2 to be an important regulator of angiogenesis and potential therapeutic target of anti-angiogenesis therapy for PNET.


The purpose of construction management is to successfully accomplish projects, which requires a continuous monitoring and control procedure. To dynamically predict project success, this research proposes an Evolutionary Support Vector Machine Inference Model (ESIM). ESIM is developed based on a hybrid approach that fuses support vector machine (SVM) and fast messy genetic algorithm (fmGA). SVM is primarily concerned with learning and curve fitting; and fmGA with optimization. Furthermore, the model integrates the process of continuous assessment of project performance (CAPP) to dynamically select factors that influence project success. CAPP was developed to identify continuous variables that have the ability for predicting project outcome. Training and test patterns are collected from CAPP database that contains 46 construction projects. These projects are real data collected by Russell from the 16 representative Construction Industry Institute (CII) member companies. K-means clustering was employed to conduct an unsupervised clustering to extract similar cases for comparison. Results show that ESIM can successfully predict the project success.


It provides techniques for fabricating a solar cell based on nanowire / microwire is. In one aspect, there is provided a method for manufacturing a solar cell. The method comprises the following steps. Providing doped substrate. Depositing on the substrate a monolayer sphere. The sphere includes nanospheres, microspheres, or a combination thereof. The sphere is trimmed in a single layer between the individual spheres of introducing space. Sphere trimmed to be used as a mask for patterning the wiring substrate. The terminal comprises a nanowire, or a combination of micro-lines. Doped emitter layer is formed on the wiring pattern. Depositing a top electrode over the contact of the emitter layer. In connection with the contact electrode is deposited on a bottom side opposite to the substrate.


Due to the impact of bad weather, overload, and three-phase unbalance, the distribution transformer may have a fault. The fault of the distribution transformer brings economic losses. Thus, it is necessary to carry out fault analysis of the distribution transformer. In this paper, the Cox proportional hazard model has been used to analyze the influence factors of the distribution transformer fault. Five indexes have been defined. The scores of the indexes have been calculated by using the negative point method and used as covariates in the Cox proportional hazard model. The weekly and monthly data have been used and compared. Results show that the load rate and the degree of current unbalance have a significant influence on the distribution transformer fault. The results of weekly and monthly data are consistent.


The catalyst-free domino reaction of α,β-unsaturated N-alkyl or N-arylaldimines with two molecules of 2-arylidene-1,3-indanediones in dry acetonitrile resulted in polysubstituted spiro[indene-2,3′-indeno[2′,1′:5,6]pyrano[2,3-b]pyridines] in moderate to good yields and with high diastereoselectivity. The reaction mechanism included sequential aza/oxa-Diels–Alder reactions via both endo-transition states. On the other hand, the catalyst-free domino reaction of α,β-unsaturated N-arylaldimines with 2,2′-(arylmethylene)bis(1,3-indenediones) afforded the mixed diastereoisomeric dispiro[indene-2,1′-cyclohexane-3′,2″-indene] derivatives in satisfactory yields. The reaction mechanism of this formal [3 + 3] cycloaddition was believed to proceed with sequential nucleophilic 1,4-/1,2-additions.


The origin and usage of the English suffix - ING has been a captivating read for some time. Regarded as both gerund and present participle it has also posed a certain challenge for the students doing English to Serbian translation exercises. This paper briefly depicts derivational and inflectional distinguishing qualities of - ING suffixes and examines the students' errors related to them. The errors have been divided according to the function of the word ending in - ING and statistically presented. Finally, as a possible future guidance, the paper offers some practical solutions to the problems identified.
Keywords: morphology, suffix –ING, gerund, present participle, translation, error analysis


When training a regression model from observations, it is often assumed that only the outputs are noisy. When the inputs are also known (or suspected) to be corrupted, the challenge is to account for this uncertainty properly. In all but the simplest of models, integrating out the inputs is intractable, even if the true input distribution were known. We present an approach for Gaussian Process machines which simultaneously accounts for data uncertainty, thus improving future predictions, and estimates the true values of the noisy inputs. Our algorithm is based on lower bounding the true marginal likelihood, and takes the form of an expectation-maximization procedure, alternately updating model parameters and adjusting estimates of cleaned input points.


What has been called Pedro Almodóvar's «post-punk dadaism» 1 in a series of films capturing fractured representations of postmodern subjectivity has fascinated critics and audicnccs on an international scale. Yet, Almodóvar's films speak from the context of contemporary Spain, a country which, in less than two decades, has undergone and continues to experience profound political and social transitions. While the young democracy has largcly cmbraced the consumer-capitalist configuration of the individual defined through the excess of matcrialism, it maintains, if only temporarily, ties to more traditional social institutions, such as family and the church. The juxtaposition of old and new forms that characterize this transitional stage of development has been depicted brilliantly by Almodóvar in films such as ¿Qué he hecho yo para merecer esto? (1984), La ley del deseo (1986), and Matador (1986). However, the work of this essay is not to examine the sociological aspects of Almodóvar's cinema, but rather to look closelv at how the aesthetic concerns of one film, La ley del deseo, embody a postmodern camp politics of representation and spectatorship.


With the rapid development of computer technology and information industry technology, the use of these technologies has been deeply applied to the management of various industries. Data time-sharing transmission can solve the problem that the system is not affected by the network; that is, it makes good use of the network and is not bound by the network. Even when the network speed is low or the network is not smooth, the system of each store can run normally, and when the network is smooth, the data will be uploaded in packets and automatically received by the server. The system is well designed with functional modules' management, including sports goods import and export management, inventory management, membership management, and ledger management. System operation can well solve the coordination work between the head office and stores; the head office can master the operation of each store, check the generated ledger at any time, form statistical reports, and guide the operation status of each store so that the stores can adjust their operation methods and learn from each other at any time. The system network management can make valuable data information aggregated, rather than single data. The head office can make overall data backup promptly to provide good logistic support for each store.