Energy saving is a significant problem in wireless sensor networks. To address this issue, a number of hybrid, dynamic, and static grouping techniques have recently been developed. This paper proposes an efficient Dingo Algorithm based on Efficient Group leader selection (DAEG) in wireless networks. A new method of grouping and choosing Group Leaders (GLs) in wireless networks is based on the Dingo algorithm. The fitness function of the Dingo algorithm depends on the node energy, neighbor count, distance, and Packet Received Rate (PRR) parameters. The DAEG approach objective is to minimize energy utilization and increase the network's throughput. This approach chooses a leader for each group after segmenting the network into compact groups. The leader coordinates communication between the group members and directs the traffic inside the cluster. It has been shown that the DAEG method outperforms conventional grouping and GL selection methods in terms of routing efficiency.


Future wireless communication systems have to address a number of challenges including the massive growth of traffic volume, number of connected devices and a wide range of new applications and operating conditions. Therefore, adaptability and extensibility at all layers of a communication system is of great importance in order to meet the desired goals. In this demonstration, we showcase a prototype of a novel link layer architecture that employs a component-based design to separate data transfer and management related functions in order support a wide range of applications. Specifically, we demonstrate a dynamic spectrum access network exploiting available radio spectrum opportunities while ensuring primary user protection. The spectrum mobility functionality is realized as an optional management application on top of a generic data transfer protocol.


Suppose that $K$ is a subfield of $\mathbb{C}$ for which the $\ell$-adic cyclotomic character has infinite image. Suppose that $C$ is a curve of genus $g\geq3$ defined over $K$, and that $\xi$ is a $K$-rational point of $C$. This paper considers the relation between the actions of the mapping class group of the pointed topological curve $(C^{\mathrm{an}},\xi)$ and the absolute Galois group $G_K$ of $K$ on the $\ell$-adic prounipotent fundamental group of $(C^{\mathrm{an}},\xi)$. A close relationship is established between the image of the absolute Galois group of $K$ in the automorphism group of the $\ell$-adic unipotent fundamental group of $C$; and the $\ell$-adic Galois cohomology classes associated to the algebraic $1$-cycle $C- C^{-}$ in the Jacobian of $C$, and to the algebraic $0$-cycle $(2g-2)\xi-K_C$ in $C$. The main result asserts that the Zariski closure of (i) in the automorphism group contains the image of the mapping class group of $(C^{\mathrm{an}},\xi)$ if and only if the two classes in (ii) are non-torsion and the Galois image in $\mathrm{GSp}_g(\mathbb{Q}_{\ell})$ is Zariski dense. The result is proved by specialization from the case of the universal curve. AMS 2000 Mathematics subject classification: Primary 11G30. Secondary 14H30; 12G05; 14C25; 14G32


We have investigated the structure and thermal dynamics of alkanethiolate layers on Au(lll) with variable temperature scanning tunnelling microscopy (STM), X-ray photoelectron spectroscopy (XPS) and voltammetry. The results build the basis for a study of electrodeposition of copper on alkanethiolate-covered Au(lll). Electrodeposition has been studied as a function of the thiolate chain length, the deposition potential and the temperature. Time-resolved in situ STM and voltammetry, both at temperatures up to 345 K, and XPS of emersed samples showed that copper can — depending on the deposi- tion potential — either form nanometer-sized islands or layers, both without destruction of the thiolate. We propose a mechanism where copper penetrates the thiolate layer. The slow deposition rate is determined only by kinetic factors since Cu/Cu2+ exchange pro- cesses cannot operate. Finally we discuss the role of thiolates as preadsorbed surfactants.


The COVID-19 outbreak posed a considerable risk to the health of people in the US and across the world. To reduce its spread, various companies in America adopted a range of preventive measures, such as telework, for the majority of their workforces. Considering that these measures have disproportionate effects on individuals, this study examined the potential relationship between socio-economic characteristics and telework status in the United States through mixed logit models developed in this research. Results indicated that telework status was significantly associated with the majority of the variables used in the models, namely, age, gender, educational status, marital status, difficulty with expenses, household size, work type, and anxiety.


Culture, individual health beliefs and distressing symptoms frequently determine women's perceptions of their menopausal transitions. Women's perceptions of mental health problems and the acceptability of different interventions greatly affect if and what a woman is willing to try as a treatment option and whether or not she will accept the possibility that her menopausal symptoms represent a comorbidity with a diagnosis, such as depression or anxiety. These perceptions have a significant impact on women's choices with regard to health practices, as well as on whether or not they will seek out medical care for their distressing symptom(s). Working with a woman's beliefs, sharing decision making, and empowering her through health education are all critical aspects of the treatment of the patient with comorbid perimenopausal symptoms, regardless of their etiology.


A first principles study of the dynamics of $^6$Li($^{2}$S) + $^6$Li$^{174}$Yb($^2\Sigma^+$)$ \to ^6$Li$_2(^1\Sigma^+$) + $^{174}$Yb($^1$S) reaction is presented at cold and ultracold temperatures. The computations involve determination and analytic fitting of a three-dimensional potential energy surface for the Li$_2$Yb system and quantum dynamics calculations of varying complexities, ranging from exact quantum dynamics within the close-coupling scheme, to statistical quantum treatment, and universal models. It is demonstrated that the two simplified methods yield zero-temperature limiting reaction rate coefficients in reasonable agreement with the full close-coupling calculations. The effect of the three-body term in the interaction potential is explored by comparing quantum dynamics results from a pairwise potential that neglects the three-body term to that derived from the full interaction potential. Inclusion of the three-body term in the close-coupling calculations was found to reduce the limiting rate coefficients by a factor of two. The reaction exoergicity populates vibrational levels as high as $v=19$ of the $^6$Li$_2$ molecule in the limit of zero collision energy. Product vibrational distributions from the close-coupling calculations reveal sensitivity to inclusion of three-body forces in the interaction potential. Overall, the results indicate that a simplified model based on the long-range potential is able to yield reliable values of the total reaction rate coefficient in the ultracold limit but a more rigorous approach based on statistical quantum or quantum close-coupling methods is desirable when product rovibrational distribution is required.


This article conducts a comparative analysis of major technological tools embedded in the modernization of Brazilian agriculture and its implications in the processes of agricultural production and human health and environment. The pesticides, produced by agricultural technoscience and transgenics, designed by biotechnology are discussed in view of their contribution, the advances and their consequences for human health, environmental and the agricultural activity. The pesticide, since the first use until today, are an immediate prospect of agriculture and productivity, while the transgenics did not have a single determination, both relate to agriculture, as regards human health, improving the nutritional efficiency. However, what occurred with this study is that both technologies are still far from providing a system of sustainable agricultural production, ecological and socially.


The development of global optimal techniques for inverse problems in electromagnetics has been successful in the last few years. However, inspired from the classical Particle Swarm Optimization (PSO) algorithm and quantum mechanics, this work presents an improved Quantum based particle swarm optimization (QPSO) by using a tournament selection strategy. Also, a new index, called Tbest (tournament best), is incorporated into the QPSO to further enhance its performance. The feasibility and merit of the proposed approach are verified by mathematic functions and an electromagnetic inverse problem.


Issues of intolerance in Indonesia, even involving children, have become the concerns of all related agencies, particularly those in children's education. Although character building has been mainstreamed in the national education system, little is known how preschool teachers contribute to the nurturance of tolerant young children as future global citizens. This study explores priority sustainable character values and their building strategies in counselling practices of pre-school teachers in West Java Province of Indonesia. Analysis of questionnaire, classroom observation and interview results by criteria of Global Citizenship Education (UNESCO, 2017) and character education in the 21st century of Bialik, Bogan, Fadel and Horvathova (2015) show that counselling topics of the participating teachers have included sustainable values of global partnership, independence, nationalism, integrity, and religiosity exercised through individual and team works. By involving social agencies such as parents, principals, and religious leaders, teachers involved their students in various characterbuilding activities. The study also recommends more detail indicators and activities for teachers to improve their students' sense of tolerance as future global citizens.


The cinema, throughout its evolution from the silent period to the present, has exhibited a fascination with the revolutionary ideas of Charles Darwin (1809–1882). Darwin's findings dislodged the human species from its position of pre-eminence, abolishing the major distinctions between human and animal and questioning the anthropocentric biases of Western thought. The impact of Darwin's theory of evolution as set out in The Origin of Species (1859) and The Descent of Man (1871) has extended from the scientific and sociological to the philosophical and cultural. In particular, literature, art and popular culture have, in recent decades, responded creatively and critically to Darwin's ideas. There are a number of key critical works on Darwin's influence on disciplines such as literature, art, feminist theory, psychology and philosophy. More than most contemporary art forms and mythic systems, the cinema has inherited a great deal from Darwin, although there are virtually no theoretical articles on the influence of the Darwinian revolution on film. With curiosity and openness, however, the cinema has explored the implications of Darwin's theories for the modern world. From Tarzan the Ape Man to King Kong, from Pretty Woman to The Piano and Alien to Gattaca, the cinema circulates narratives with Darwinian and post-Darwinian themes: survival, adaptation, evolution, inheritance, sexual selection, the malleability of the body and the primacy of the emotions. As Gillian Beer demonstrates in Darwin's Plots, Darwin's stories about evolution, sexual selection, generation and the struggle to survive underpin many forms of our cultural production. This paper will focus on human and animal relationships, specifically films in which woman and the beast are represented as an erotic couple. Darwin himself did not refer to


Reports from several laboratories (Happold and Hoyle, 1936; Epps and Gale, 1942) have demonstrated that tryptophanase activity is reduced when cells are harvested from a medium containing glucose and that this effect is not entirely due to the increased hydrogen ion concentration resulting from the utilization of the carbohydrate by the microorganisms. Dawes and Happold (1949) reported data suggesting that apotryptophanase formation is inhibited when growth takes place in the presence of glucose. The present studies were initiated because of our previous work on the effects of carbohydrates on the deaminases of bacteria (Boyd and Lichstein, 1951, 1953), and the results obtained emphasize that the formation of tryptophanase is reduced markedly when bacterial cells are grown in the presence of glucose or other carbohydrates. In addition this report is concerned with the nutritional factors required for the adaptive formation of tryptophanase.


The cubic equation of state (CEoS) is a powerful method for calculation of (vapor 1liquid) equilibrium (VLE) in poly- mer solutions. Using CEoS for both the vapor and liquid phases allows one to calculate the non-ideality of polymer solutions based on a single EoS approach. In this research, vapor-liquid equilibria calculations of polyvinyl acetate (PVAc)/solvent solutions were per- formed. In this approach, eight models containing PRSV and SRK CEoS separately combined with four mixing rules namely vdW1, vdW2, Wong-Sandler (WS), and Zhong-Masuoka (ZM) were applied to calculations of bubble point pressure. For the better predic- tion, the adjustable binary interaction parameters existing in any mixing rule were optimized. The results were very acceptable and satisfactory. Absolute average deviations (%AAD) between predicted results and experimental bubble point pressure data were calcu- lated and presented. The capability of two cubic equations of state had a good agreement with experimental data and predict the cor- rect type of phase behavior in all cases, but the performance of the PRSV 1vdW2 was more reliable than the other models with 2.65% in AAD for total of solution systems. V C 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40651.


A complex change management process is currently underway in many Australian universities. It involves the convergence and/or integration of library, computing and IT services. The process has profound implications for reference and information services and their clients, as evidenced by the recent increase in library literature both for and against integration. This paper identifies the issues driving convergence in universities, and the challenges this represents, investigates the impacts of full integration on university libraries and their clients, and recommends strategies for the successful management of convergence and integration involving established reference and information services teams.


. Recently we introduced the hypergraph matrix model (HMM), a Hermitian matrix model generalizing the classical Gaussian Unitary Ensemble (GUE). In this model the Gaussians of the GUE, whose moments count partitions of finite sets into pairs, are replaced by formal measures whose moments count set partitions into parts of a fixed even size 2 m ≥ 2. Just as the expectations of the trace polynomials Tr X 2 r in the GUE produce polynomials counting unicellular orientable maps of different genera, in the HHM these expectations give polynomials counting certain unicelled edge-ramified CW com-plexes with extra data that we call (orientable CW) maps with instructions . In this paper we describe generating functions for maps with instructions of fixed genus and with the number of vertices arbitrary. Our results are motivated by work of Wright. In particular Wright computed generating functions of connected graphs of fixed first Betti number as rational functions in the rooted tree function T ( x ), given as the solution to the functional relation x = T e − T .


THE PRESIDENT said all would agree that the Society was greatly indebted to Mr. Jocelyn Swan for this address. All present must have admired the ease and fluency with which he delivered it, and without anything more than a very few notes. Such ease could only come from a profound and intimate knowledge of the subject. Major DOBLE agreed with the President that all had enjoyed the address enormously. He agreed with Mr. Swan that the cause of stricture in gonorrhoea cases was not the actual gonorrhoea, but the way in which it was treated, especially in the old days, when silver nitrate in various strengths and other strong antiseptics were employed. One man injected pure carbolic into the urethra, and the result was a solid stricture extending four inches. In former days, too, much time was spent in out-patients' departments in attempts to reduce these strictures. That this was so largely altered was due to the abandonment of such strong astringents. He used to receive a number of stricture cases from one doctor, and he found that this practitioner used to supply a dozen or so medicated bougies to each patient. One patient said he passed his water and then pushed a bougie up his urethra, and then started dancing with pain. His own view was that the bulbous urethra was most often affected with stricture because the antiseptic solution used remained in that part. After injecting a strong antiseptic the man did not feel inclined to pass his water, and therefore he held it as long as he possibly could. Dr. WRIGHT (Norwich) asked as to the occurrence of fatal air embolism after examining patients with the urethroscope. He knew of two instances-not his own patients-and he had read of others in the journals. Mr. Wyndham Powell said these cases happened after


Abstract: On the sand beaches of the Bay of Bengal, from Bichitrapur in Orissa to Mandermani in West Bengal, population dynamics of Ocypode macrocera (H. Milne Edwards, 1852) were investigated. The crabs are found across the coastal areas that face the sea. Bichitrapur, Talsari, Udaipur, New Digha, Mohana, Shankarpur, Tajpur, and Mandermoni were the principal study locations. The infra-littoral sand flats zone is where the Red Ghost Crabs live. The development of the particular stretch of beach and the prevalence of crab burrows are related. Crab activity occurs both during the day and at night. One to three openings towards the sea can be found in each crab burrow. EIA (Environmental Impact Assessment) is an essential study required before onset of any project or for any ongoing project. This EIA study was conducted in 2017, prior to the start of "Marine drive & Tajpur port" construction, and in 2020, following completion of "Marine drive& Tajpur port" by Rammohan College. At the construction areas, it was discovered that the Red Ghost Crab population had substantially decreased. Additionally altered is the burrow distribution pattern. An essential ecological stabilizer of Sea beach is the red ghost crab. Additionally, it was discovered that the sea beach began to erode where the crabs were completely gone.


The present invention relates to a method for producing improved of itraconazole (Itraconazole), more specifically: 1) the introduction of a nitro phenyl (nitrophenyl) a piperazine derivative of phenol reaction, and 2) the reduction reaction and the protection reaction of nitro, 3) introduction of the hydrazine, 4) triazol-generating reaction, 5) 2-bromo-introducing reaction of the parent butane, and 6) via a deprotection reaction of a phenol preparing a triazole (triazole) portion, and 7) prepared triazole ( triazole) will be high and the combination of parts and cost-protected propanetriol derivative relates to a process for preparing itraconazole (itraconazole) in a high yield. Itraconazole, a triazole, antibacterial, antifungal


A method for detection and registration of child abuse (demonstrated or suspected) was experimentally applied ata suburban community of Santiago Chile as a contribution to the understanding of the problem in the country and tofuture development of a national case register. The questionnaire was applied by trained personnel or health,education ana justice institutions to cases detected at health centers, schools, police stations and justice courts and ro apaired control sample of unrelated cases from the same institutions. Children's characteristics, type of abuse andbiological, social and family risk factors were recorded. Characteristics of 145 cases and 125 controls werecompared, as well as subtypes of abuse, and different maternal ages. Significant differences were respectivelyrecorded in the frequency of family members with mental diseases (23.8% vs. 1 1.2%) that lived in the same householdas the abused case (67.6% vs. 14.3%); absence of alcohol comsumplion, (21% vs. 44%) , problem alcohol drinkers(23.8% vs. 7.2%) and illicit drug consumtion {15.5% vs. 7.2%) among family members; behaviour problems of thechild [54% ante 16,8%]; use of social aid programmes (26.9% vs. 12,8%); attendance to public townhall managedschools [79.4% vs. 66.3%); good quality housing [68.8% vs. 88.9%), provissional housing [31,4% vs. 11,5%);participation in community (6.2% vs. 1 3.6/0). These results remain however provissional till completion of wider studieswilh more refined instruments.(Keywords: battered child syndrome, child abuse.)


Abstract N,N,N′,N′‐Tetraoctyl‐3‐oxapentanediamide (TODGA) in n‐dodecane was studied to characterize the aggregation properties of the extractant and the formation of a third‐phase when nitric acid is extracted. Tensiometry and small‐angle x‐ray and neutron scattering (SAXS and SANS) revealed the presence of small aggregates dispersed in the diluent. The aggregates are spherical reverse micelles consisting of a polar core containing water and the extracted ions and surrounded by approximately four extractant molecules. When the initial nitric acid content is increased, the aggregates remain spherical, their size increases as more water and ions are extracted and inter‐particle attraction increases. The sticky hard‐sphere model proposed by Baxter was used successfully to describe the small reverse micelles of the organic TODGA phases and quantify their interactions. These attractive interactions were found responsible for the formation of the third‐phase.


Calibration is a common procedure to increase the accuracy of machine tools. Estimation as an important part of the calibration has been conducted by using various algorithms. This paper presents the implementation of nonlinear least squares (Gaussian least squares differential correction) algorithm to estimate the geometrical parameters of 3PRR planar parallel kinematics manipulator having nonlinear kinematics which can be used in a hybrid serial-parallel kinematics machine tool. The independent parameters are first estimated followed by the dependent parameters. The convergence to the true values with zero estimation error is guaranteed with any initial estimates provided that no measurement noise is introduced. Subsequently, the estimation by incorporating noise from all measurement devices is conducted which gives the estimates with certain estimation errors. While the estimation errors are affected by the noise level of the measurement devices, it is shown that larger size of measurement samples increases the estimation accuracy. Finally, the uncertainty of the estimates is evaluated by using Monte Carlo simulation.


Asian Financial Crisis in 1997 not only introduced the term of corporate governance but also drew attention of the public about the weaknesses of Malaysian corporate governance practice. After 1998, Malaysian government decided to adopt corporate reforms that could enhance the quality of good corporate management practice. This included the introduction of the new Malaysian code and rules for corporate governance. The debate of corporate governance in Malaysia are often limited to agencies involved directly in law enforcement such as the Ministry of Finance, Kuala Lumpur Stock Exchange (KLSE), Securities Commission (SC) and Registrar of Company. High Level Finance Committee Report 1999 defined Corporate Governance as "The process and structure used to direct and manage the business and affairs of the company towards enhancing business prosperity and corporate accountability with the ultimate objective of realising long-term shareholder value, whilst taking into account the interests of other stakeholders".


This chapter discusses the relevant provisions of Art. 83 et seq. of the Grundgesetz (GG) with regard to the execution of federal laws by the federal state and the states. In the Federal Republic of Germany, the federal state and the states are each assigned their own separate administrative powers by the Grundgesetz. The question that arises is how strict the separation of state administration vs federal administration of federal laws is required by the constitution, and whether it always makes sense. To answer this question, the chapter examines the Federal Constitutional Court's jurisprudence concerning the presumption of state responsibility and joint administration (joint execution of federal laws) between federal and state governments. It also considers the states' autonomous execution of federal laws as well as their execution of federal laws on federal commission before concluding with an analysis of the federal administration/execution of federal laws.


Abstract To evaluate the influence of minor and impurity elements on the solidification cracking susceptibility in austenitic stainless steel welds, the transverse Varestraint test was conducted using several extra high purity type 310 stainless steels with different amounts of C, Mn, P and S. The characteristic influence on solidification cracking could be expressed by the ratio of P/S/C≈1∶1·3∶0·56, while Mn affected solidification cracking to a negligible extent. A theoretical approach revealed that the reduced solidification cracking susceptibility with decreasing C, P and S contents could be attributed to the suppression of solidification segregation.


The working principle of a large hydropower station is to guide the high-pressure water flow to impact the turbine to rotate and generate electricity. The high-pressure water flow impacts the turbine blades, which forms complex high-speed eddy currents in the spiral case and the draft tube and causes complicated vortex-induced vibration problems. Traditionally used harmonic response methods and dynamic time-history analysis methods are difficult to reflect this complex fluid-solid dynamic coupling problem. In this paper, the bidirectional fluid-structure interaction (FSI) simulation analysis theory for a large hydropower house is studied, and the analysis methods of geometric simulation, mechanical simulation, and vibration energy transmission path simulation are presented. A large-scale 3D fluid-hydraulic machinery-concrete structure coupled model of a hydropower house is established to study the vortex-induced vibration mechanism and coupled vibration law during transient unit operation. A comparison of the fluid results against the in-site data shows good agreement. Structural responses of vibration displacement, velocity, and acceleration reveal coupled regularity of hydraulic machinery-concrete structure-fluid during blades rotating periods, and it comes to the conclusion that the turbine blade rotation is the main vibration source of the hydropower house. The research results can provide a scientific basis for the design and safe operation of the hydropower house.


Adenovirus infection subverts nucleolar structure and function. B23 is a nucleolar protein presentin two isoforms (B23.1 and B23.2) and both isoforms have been identified as stimulatory factorsfor adenovirus DNA replication. Here, it is demonstrated that the two isoforms of B23, B23.1and B23.2, interact and co-localize differently with viral DNA replication proteins pTP and DBP inadenovirus-infected cells. Thus, the mechanism by which the two proteins stimulate viral DNAreplication is likely to differ. These data also demonstrate the importance of testing both isoformsof B23 for interactions with viral proteins and nucleic acids.


in association with A in one of the seven cases which were used in this research. The organism Type A is spherical, and varies in size from a minute dot to a ?diameter of 3/a. It grows on agar as a viscid, translucent streak. The organism Type C is spherical, with a diameter of 5 to 10/a, has a capsule, cell-network, and refractile granules, also nuclear bodies staining by Romanowski's method. It multiplies ?readily by budding when grown upon glucose agar. After inoculation it may multiply by sporulation. Type A never develops into Tjpe C in vitro, but when injected into animals Type A (1) may not show morphological change, (2) may form clubs and ovals,


Aerial-hawking echolocating bats present an interesting model for studying how a moving listener interacts with moving sound sources. During foraging, relative movements between the bat and its prey introduce echo variation, which is further influenced by the timing of biosonar emissions with respect to insect wingbeats. Through systematic characterization of echoes from fluttering moths, this study aims at understanding how intermittent and highly variable echo information may be perceived and integrated by foraging bats for prey detection, tracking, and discrimination. Calibrated broadband echoes from frequency-modulated linear sonar sweeps were measured from live, fluttering moths of different morphological features with concurrent high-speed video recordings. The measurements are used to estimate the probability distribution of echo amplitudes as a function of moth morphology, wingbeat phase, and body orientation, as well as to predict changes of echo characteristics as the bat approaches the prey. Signal detection theory is then applied to model the bat's perception of prey presence as influenced by changes in biosonar emission rate in different phases of the foraging process. These results can be further integrated with neurophysiological findings on the bat's internal representation of space for a better understanding of this agile and efficient biosonar system.


The invention discloses a method and a system for modifying a files. When the a file is modified, a recovery file is generated and records a data block address and a data block content, which are used for modifying contents in the file, of a modification instruction; if the modification is finished, the recovery file is deleted; if the modification is interrupted, the file is recovered according to the recovery file; therefore, the file cannot be damaged, and the influence on the application and the operation, which are related to the file, is avoided. W; when the a file is red, whether the a recovery file exists is judged first; if the recovery file exists, the file is recovered according to the recovery file, and the correctness of the reading operation is guaranteed.


The purpose of the paper is to evaluate the quality of ecological environment of Cuihu Wetland Park in Beijing in order to provide some economic decision-making references for further development of Haidian District's wetlands.Methods employed include technical tools(ecological environment quality Composite Index) together with theoretical analysis to establish an quality evaluation index system for Cuihu Wetland Natural Reserve.The result shows that Cuihu Wetland Nature Reserve should be divided into several functional areas:core zone,buffer zone,transitional zone or experimental areas and protection zone.It is concluded that we need to develop and protect different functional areas according to concrete conditions.


Techniques for activity recognition are fundamental components of any context-aware system. Indeed, precise knowledge of the user's current activity is necessary in order to thoroughly tailor services to the user's context.


Introduction
 Although many new therapeutic agents have been introduced in the field of AML, the most important intensive induction regimen of AML patients is still 7+3 chemotherapy based on cytarabine and anthracycline. Currently, major guidelines recommend to exam bone marrow (BM) assessment in 14-21 days after the initiation of induction to determine whether to proceed with intensification chemotherapy. However, there is no solid evidence that these timings are most optimal. If the evaluation at an earlier time point is prognostic for response, earlier intensification could be considered. In this regard, we investigated if the BM blast rate at the 7th day after the start of 7+3 chemotherapy (D7 BM blast) was useful in predicting the treatment response of induction chemotherapy.
 Methods
 We retrospectively collected the data of patients who were newly diagnosed with AML from February 2002 to February 2021, received induction chemotherapy by 7+3, had a D7 BM examination without any intensification. A total of 665 patients were enrolled and we analyzed the prognostic significance of the D7 BM blast for the induction treatment response (complete remission or complete remission with incomplete hematologic recovery (CR/CRi)). In addition, we analyzed whether the predictive significance of the D7 BM blast varies by the patient's cytogenetic features by Medical Research Council classification (MRC risk). Then, we evaluated the diagnostic ability of the D7 BM blast by the receiver operating characteristic (ROC) curve for treatment response prediction. To find an optimal D7 BM blast cut-off value, the value that maximizes Youden's index was investigated.
 Results
 Among 665 AML patients who underwent 7+3 without intensification, the proportion of patients who acquired CR/CRi after single induction was 68.3%. A significant decrease in the CR/CRi rate was observed in the intermediate/adverse MRC group according to the increase of the D7 BM blast (tests for the trends in the intermediate and adverse group, p<0.001 and p=0.008, respectively; Figure 1). In univariable/multivariable (using covariates of age, sex, etiology, and MRC risk) logistic regression models, the D7 BM blast showed a significant correlation with the CR/CRi rate in the intermediate/adverse cytogenetic group (Table 1). To evaluate the usability of the D7 BM blast as a predictive tool, the ROC curve for the treatment response prediction was plotted (Figure 2) and the D7 BM blast was significantly predictable only in the adverse MRC risk group (Area under the curve: 0.7007, Mann-Whitney test statistics p=0.002). The D7 blast cut-off in the adverse MRC risk group which maximizes Youden's index was 4-4.9%, near to 5%, which is the cut-off used to evaluate the treatment response. The sensitivity and specificity for treatment response prediction according to D7 BM blast <5% or not were 82.8% and 61.1%, respectively.
 Conclusion
 The BM assessment performed at 7 days after 7+3 chemotherapy was available to predict the treatment response in intermediate and adverse cytogenetic risk patients. In particular, it can be practically used in patients with adverse cytogenetics, and a value of around BM blast 5% can be used as cut-off for response prediction. Early intensification in these patients could be considered, which would be beneficial in various aspects such as shorter nadir period or hospital stay and possibly better treatment response compared with the current strategies of later intensification or second induction.
 Figure 1 Figure 1.

 Kim: Novartis: Research Funding; BMS: Research Funding; Pfizer: Research Funding; ILYANG: Research Funding; Takeda: Research Funding. Lee: Alexion, AstraZeneca Rare Disease: Honoraria, Membership on an entity's Board of Directors or advisory committees. Kim: AbbVie: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; AIMS Biosciense: Consultancy, Honoraria; Amgen: Consultancy, Honoraria; AML-Hub: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Astellas: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; BL & H: Research Funding; BMS & Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Boryung Pharm Co.: Consultancy; Daiichi Sankyo: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Janssen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Handok: Consultancy, Honoraria; LG Chem: Consultancy, Honoraria; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Pfizer: Consultancy, Honoraria; Pintherapeutics: Consultancy, Membership on an entity's Board of Directors or advisory committees; Sanofi Genzyme: Honoraria, Speakers Bureau; SL VaxiGen: Consultancy, Honoraria; VigenCell: Consultancy, Honoraria.


In this study, we investigated the change of antioxidant activity and flavonoid contents by fermentation of Citrus grandis Osbeck peel (CGP) using the Saccharomyces cerevisiae (KCCM35053), comparing to unfermented CGP. Total flavonoid content in the fermented Citrus grandis Osbeck peel (FCGP) was 3,768 g/100 g sample and higher than that of CGP. The antioxidant activities of FCGP was determined by DPPH, hydroxyl, alkyl radicals, and hydrogen peroxide scavenging assays. FCGP showed higher activities than CGP in all scavenging assays. The IC 50 values of FCGP were 261.3 ㎍/mL for DPPH; 1,474 ㎍/mL for hydroxyl; 90.9 ㎍/mL for alkyl and 1,195 ㎍/mL for H₂O₂ in respective scavenging assays. Flavonoid compositions of both samples were determined by liquid chromatography/mass spectrometry (LC/MS). In the spectrum FCGP was similar to CGP in the contents of neohesperidin, naringin and an unknown No. 7 compound, but some unknown compounds (No. 1, 2, 4, 5, 6) were higher than CGP in each flavonoid contents. Therefore, the fermentation of CGP could increase the contents of unknown compound and improved antioxidant activities.


The information transformation of neuronal dynamics into a human's built information network that structures and assembles an incoming information is introduced, based on Information Macrodynamics. Formalized functions of this mechanism represent a general attribute of a system's cognition, which is useful in understanding brain functions and artificial design.


Bullous pemphigoid (BP) is the most common autoimmune blistering disease in older people, and is associated with significant morbidity and mortality. Oral corticosteroids are usually effective but the side‐effects are thought to contribute to the high morbidity and mortality rate. Treatment with oral tetracyclines may be effective but high‐quality, randomized controlled trials (RCTs) are needed to confirm this.


From the angle of high-tech enterprises in the growth stage,it makes an analysis of the current research situation from domestic or foreign and the problems existing in the assessment of its value,then puts forward two kinds of value evaluation models in accordance with characteristics of growth stage,namely improved discounted cash flow model and network analysis model,and evaluates the advantages and disadvantages of the models.Finally,by using entropy value method,it makes an analysis for the influence factors of high technology enterprises' value and the functions of the index for enterprises' value.


This study aims to analyze and describe data on the understanding of YAPNUSDA elementary school teachers of High Order Thinking Skills (HOTS) and their implementation in learning. This study is a descriptive study that describes HOTS's understanding of the teacher and its implementation in learning. The data collection tool used was a questionnaire. The results of this study indicate that in general the data obtained is that the teachers in the study location schools do not yet understand about HOTS. They can't even explain the definition of HOTS. The lack of understanding of HOTS certainly has an impact on the implementation of HOTS in the tools for assessing learning performance, including the exam questions jointly prepared by the editorial team. The most frequently cited reason that also hinders teachers is that they do not yet understand HOTS and the technique of formulating instruments with verbs that measure HOTS.


This article expounds the connotation and roles of educational industrialization. The author emphasize that the limitation of educational industrialization must be recognized. lastly, some effective ways of promoting educational industrialization at present are discussed.


The development of smart grid functions as an efficient way to deal with the global climate change and energy shortage problems.Considering the status quo of China's smart grid,the economic benefits are analyzed from the four links: generation,grid,consumption and the other benefits,and correspondingly the comprehensive evaluation index system is established.Then the paper proposed the economic benefits evaluation model for smart grid based on interval numbers,by combining the quantitative and qualitative analysis and introducing the interval numbers to reflect the fuzzy features of expert judgment.As actual evaluation indicates,the suggested evaluation index system is reasonable and reliable for the introduction of interval numbers can avoid subjective judgment,thus it can be used to provide references for smart grid investment decision-making.


In this paper, an approach used in developing and validating a simulation model for studying the heterogeneous traffic is presented. As part of the model development, longitudinal and lateral updating procedures for the vehicular movement have been discussed in detail. Vehicle movement patterns on mid-block sections are studied and utilized this information as input for developing the vehicle updating procedures. This model is validated at macroscopic level for both urban and rural heterogeneous traffic conditions. A methodology adopted for collecting the macroscopic data from the simulation model using "cell" as a unit of vehicle is presented. Using flow-occupancy relationships in terms of cells, utility of this methodology in analyzing the heterogeneous traffic is presented. Traffic observed on urban and rural mid-block road sections has been studied using this model.


Formal modeling, simulation, and analysis of complex systems is valuable because it can provide insights into complex systems that are too expensive or difficult to analyze otherwise. In this work, we present an approach for improving simulation trajectory choices in a Monte Carlo framework using a combination of crowdsourcing, machine learning, and data mining. We apply machine learning to analysis of a formal model of biodiesel production as a method of improving the efficiency of the crowd sourced mobile simulation analysis of the model. Data is collected and data mined in a central server where machine learning is applied and recommendations from the machine learning algorithm are fed back to crowd workers via suggestions on the mobile app. Ultimately, we show that this approach can improve efficiency of optimal safe state identification in the biodiesel model analysis.


ve:To investigate the relationship between the Ser-9-Gly polymorphism in the dopamine D3 receptor gene(DRD3) and late-onset Alzheimer's disease (LOAD) in the Han Chinese. Methods: The Ser-9-Gly polymorphism in the DRD3 gene in 107 patients with LOAD and 146 age-matched normal elderly subjects were examined by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ). Results: The frequency of allele 1 of DRD3 was 77% in both AD patients and controls, the frequency of allele 2 of DRD3 was 23% in both groups, the frequency of 1/1 genotype was 59% and 58% in AD and controls respectively, the frequency of the homozygosity of 2/2 genotype was 5% in both groups. No significant differences for alleles or genotypes were found in the Chinese population ( P 0. 05). Conclusion: Our findings indicated no association between Ser-9-Gly polymorphism in the DRD3 gene and LOAD in Han population in Guangzhou.


AbstractThis study draws on the participatory political philosophy of Benjamin Barber to assess the contribution of public access cable television to political communication in the United States. In contrast to neo-liberal political theory which views government-mandated media access as infringing on the speech rights of media owners, Barber's participatory democratic theory positions direct and widespread access to the media as a vital aspect of democratic processes. Barber puts forward a set of concepts which describe the various functions of democratic "talk" and which provide a theoretical framework for understanding some of the ways in which access television functions as a political communication resource. Using interviews and original source materials, the study examines the political uses of access television by radical media projects, a type of media seldom granted access to commercial or public television. In their attempts to organise and empower communities that have been under represented or ...


The traveling salesman problem(TSP) is one of the classic NP-Hard combinatorial optimization problems.Efficient heuristics for the TSP have been the focus in research of computer science at all times.As a new tool to describe the structure of the TSP,the fat is essential for heuristic algorithm design.Since research on the fat is still at the beginning stage,It still lacks theoretical results and related heuristic algorithms.In this paper Firstly,the fat computational complexity for the TSP is investigated.It's proved that it is NP-Hard to obtain the fat of the TSP through construction of biased instances,i.e.,there is no algorithm to get the full fat of the TSP in polynomial time on the assumption P≠NP.Furthermore,a meta-heuristic——dynamic candidate set search(DCSS) was proposed by analysis of the relationship between local optimal solutions and the fat.And the DCSS was applied to the LKH,one of the best existing algorithms for the TSP to improve it.Extensively wide experimental results on typical instances from the benchmark—TSPLIB indicate that the improved algorithm has a better performance than the LKH in terms of solution quality.This new fat-based heuristic shows a new way for other NP-hard problems.


By prescribing sea surface temperature anomalies (SSTAs) over eastern equatorial Pacific in January-March, the lag influence of ENSO (El Nino and La Nina) on monsoon over East Asia has been studied. The results suggest that, due to the excitation of atmospheric low-frequency oscillation by the SSTA, ENSO has significant lag influence on the monsoon over East Asia.During the summer after El Nino, the subtropical high over western Pacific is intensified and shows the northward and westward displacement, meanwhile, the rainfall over East China is below normal, especially in North China; during the winter after El Nino, both the Asian trough and the winter monsoon over East Asia are strengthened. During the summer after La Nina, the anomalous subtropical high prevails over the lower reaches of Yangtze (Changjiang) River, the rainfall between Yangtze and Huaihe Rivers is below normal; during the winter after La Nina,both the Asian trough and the winter monsoon over East Asia are weaker. Compared with La Nina, the effect of El Nino is stronger, but it is not always opposite to the one of La Nina.


bership in the Shakers, for example, illustrates that the community was much less "stable" than I had earlier supposed. A lot of people passed through Shakerism and then moved on. Celibacy and other aspects of Shaker authoritarianism were truly difficult crosses to bear. The Onedia Community seems to have had less harrassment from the world than I had earlier supposed. Foster insists that the community deteriorated from within more than from outside assaults. My only question is, if that is so, why was John Humphrey Noyes, the founder, forced to flee to Canada when he was charged by outsiders (?)with statutory rape?


This essay suggests a new way of understanding the notorious Indian guru, Bhagwan Shree Rajneesh, by examining the intimate relationship between his religious teachings and his business practices. Rajneesh's ideal was in fact that of 'Zorba the Buddha', the perfect synthesis of the spiritual and material, the religious and capitalist impulses. After analysing and criticizing the classical Weberian concept of 'charisma', this paper argues that charismatic authority is by no means incompatible with bureaucratic organization or rational business practices. On the contrary, not only can charismatic authority be combined with a complex bureaucratic organization, but it can also be transformed into a kind of 'commodity' which is bought and sold on the consumer market. Rather than a 'routinization of charisma' what we find in the Rajneesh movement is a kind of 'commodification' and 'commercialization' of charisma. Bhagwan offered (and sold) his followers the promise of the same charismatic authority and divine f...


Parents of children with Down syndrome face many challenges related to their children's disability. Th ey manage to raise their children primarily thanks to their internal resources, protective psychological traits and help from other people. Th e aim of this study was to investigate the level of ego-resiliency as an important personality trait in a group of mothers and fathers of children with Down syndrome. Th e relationship between ego-resiliency and parental satisfaction was also studied. Th e sample consisted of 126 parents (75 mothers and 51 fathers). Our results show that there is no diff erence in the level of ego-resiliency between mothers and fathers of children with Down syndrome. Nevertheless, it is noticed that there is a diff erence in perceived stress, psychological well-being and some aspects of parental satisfaction between parents with high and low levels of ego-resiliency. Th ese results give an interesting insight into the internal functioning of parents of children with Down syndrome.


The measurement target design methods and target validation are provided. The method comprises the step of adjusting the measurement target design model to compensate for the phase and the estimated disparity using as an estimate of the mismatch (discrepancy) between the actual target corresponding on the OCD data, the target model and the wafer involved in the design the measurement target . Only validated target is to enable compensation for the inaccuracy resulting from manufacturing process variations, comprising: an overlay target features, can be a size optimized to be measured by the sensor ODD. Further, the method may include a modification to the workflow between the manufacturer (manufacturer) as measured vendor (vendor metrology) provide more measurement target design model fidelity is high and, ultimately, increase the accuracy of measurement instrumentation.


Entrepreneurship Education (EE) represents a challenge for education systems across Europe and in particular for Italy, where EE is largely confined to technical and vocational studies. Introducing EE in the general secondary school curriculum means focusing on the development of skills and abilities now deemed an essential part of what is termed the "entrepreneurial mindset". This in turn requires the adoption of teaching methodologies suitable for fostering those essential capabilities. Indeed, EE stretches beyond the acquisition of specific knowledge, encompassing efforts to make students active participants in their own learning, career path and life in general. This paper describes an EE training model defined within the European project "I can...I cannot...I go! Rev. 2", funded by the Leonardo da Vinci Programme - Transfer of Innovation. It reports initial qualitative evaluation of the trial phase conducted with fourth-year students attending a technical school for tourism in Palermo.


Bauhinia variegata is a small to medium-sized tree. It grows to a height of about 10-12 m and is deciduous. It is mostly grown in tropical region. The genus Bauhinia includes about 600 species including shrubs, trees and vines. It is generally planted as an ornamental plant. It grows throughout India and China. It is a reliable greenhouse species which grows at an altitude of 1800 m in Himalayas (Deswal et al., 2015). Bauhinia variegata belongs to family Leguminosae (Caesalpinioideae) is also called Mountain Ebony (English), Rakta kanchan (Marathi), Kachnar (Hindi). It is a medium-sized, deciduous tree found throughout India, at an altitude of 1800m in Himalayas. Leaves are broader, rigidly sub-coriaceous, deeply cordate with two leaflets, connate for about two-thirds up, leaflets are ovate, rounded at apex, 10-15cm long, pubescent beneath when young. Flowers are variously colored, lateral, sessile, stamens 5, staminodes absent, fruits flat; hard glabrous dehiscent pods, 10-15 seeded (Patil et al., 2012). The genus Bauhinia Linn. consists of shrubs or trees, distributed throughout the tropical regions of the world. In India, about 15 species of this genus are found. Bauhinias are mostly propagated from seeds. Tannins, fibre, gum and oil are procured from Bauhinia species which are useful in industries. The plants bear fragrant and beautiful flowers. They are grown as ornamental plants. Linn, B tomentosa B racemosa B retusa B purpurea B variegata Lam, Roxb, Linn, Linn and Roxb. are widely used in the B malabarica traditional systems of medicine(Mali et al., 2009).


: Two indices addressing buffer solution are differentiated, which are used to gauge punctual and durative buffer function, respectively. Buffer strength β and buffer capacity α are accordingly suggested for the names of the indices (their corresponding mathematic expressions are differential formula and integral formula, respectively). The feasibility of introducing differential formula into calculation of durative capacity in the textbooks is intensively discussed, and the applicable conditions of this practice are pointed out, which forms the basis of suggestions for improvement on some contents of the textbooks.


Introduction. A simple microscopic diagnostic quantification system for neutrophile granulocytes (NG) was developed evaluating a single focal point (CD15 focus score) which enables the detection of bacterial infection in SLIM (synoviallike interface membrane) Additionally a diagnostic algorithm is proposed how to use the CD15 focus score and the quantification software (CD15 Quantifier). Methods. 91 SLIM removed during revision surgery for histopathological diagnosis (hip; n=59 and knee; n=32) underwent histopathological classification according to the SLIM-consensus classification. NG where identified immunohistochemically by means of a CD15-specific monoclonal antibody exhibiting an intense granular cytoplasmic staining pattern. This pattern is different from CD15 expression in macrophages showing a pale and homogenous expression in mononuclear cells. The quantitative evaluation of CD15-positive neutrophils granulocytes (CD15NG) used the principle of maximum focal infiltration (focus) together with an assessment of a single focal point (approximately 0.3 mm 2 ). This immunohistochemical data made it possible to develop CD15 Quantifier software which automatically quantifies CD15NG. Results. SLIM-cases with positive microbiological diagnosis (n=47) have significantly (p<0.001, Mann-Whitney U test) more CD15NG/focal point than cases with negative microbiological diagnosis (n=44). 50 CD15NG/focal point were identified as the optimum threshold when diagnosing infection of periprosthetic joints using the CD15 focus score. If the microbiological findings are used as a 'gold standard' the diagnostic sensitivity is 0.83, specificity is 0.864. (PPV: 0.87; NPV: 0.83; accuracy 0.846; AUC: 0.878.) The evaluation findings for the preparations using the CD15 Quantifier (n=31) deviated in an average of 12 cells from the histopathological evaluation findings (CD15focus score). From a cell-count greater 62 CD15 Quantifier needs on average 32 seconds less than the diagnostic pathologist. Conclusion. The CD15 focus score, and the use of the «CD15 Quantifier» software which is thereby made possible, offers an automated procedure which shortens the mentally tiring and time-consuming process of microscopic cell-counting. The proposed diagnostic algorithm (how to use the CD15 focus score and the quantification software, CD15 Quantifier) may contribution towards the standardisation for periprosthetic joint infection and diagnosing bacterial infections in the SLIM.


In this paper we consider secondary dominating sets, also named as \((1,k)\)-dominating sets, introduced by Hedetniemi et al. in 2008. In particular, we study intersections of the \((1,1)\)-dominating sets and proper \((1,2)\)-dominating sets. We introduce \((1,\overline{2})\)-intersection index as the minimum possible cardinality of such intersection and determine its value for some classes of graphs.


The development of cultural industry cluster should be considered within global supply chain,also the same kind of enterprises within a megalopolis should be clustered with specialty,which is to construct complete supply chain from creator to customer.Besides,interaction between governments and enterprises can promote the development of cultural industry cluster.


This paper addresses key theoretical and methodological challenges that have been raised regarding the use of neuroscience in organizational research. In doing so, we present the results of an fMRI study that integrated theories of attention and intentional change in proposing that coaching interactions focused on the Positive Emotional Attractor state (PEA) would be associated with big picture thinking and, thus, global attention. On the other hand, coaching interactions focused on the Negative Emotional Attractor state (NEA) would be associated with attention to local details. Using neuroimaging to examine conjunctive cortical activation between PEA/NEA coaching and global/local visual attention, we found robust support for hypotheses related to this proposition. A pattern of overlapping neural activation was found linking PEAand NEA-based coaching to global and local attention, respectively. PEA coaching and global processing produced activations that were lateralized to the right hemisphere and located in the visual associative cortex (e.g. right precuneus and middle temporal gyrus). Neural activity associated with NEA coaching and local processing was left lateralized and located in the early visual areas (e.g. left inferior occipital gyrus). This overlap suggests attentional processing is a highly relevant factor in determining how individuals respond to different kinds of coaching. COACHING AND ATTENTION 4


We present an approximation method and numerical analysis for a two-dimensional problem that is obtained by sampling in time and linearising a problem regarding two-phase flow of a viscous fluid without mixing. The fluid satisfies the conditions for the incompressible Navier-Stokes equations, and it is assumed that there is a time-varying curved interphase boundary (interface) between the liquid phases of different densities and viscosities. The case of convection dominated flow, i.e., the case of a small coefficient of viscosity, is considered. To account for this feature, the finite element discretisation of the problem included ∇div -stabilisation. The range of the optimal choice of the ∇div - stabilisation parameter is agrees with the range for a problem with continuous coefficients and a curved interface.


This study aims to know the role of human resource of Village Owned Enterprise (VOE) in improving village economy in Labuhan Jambu Village, Tarano Sub-District, Sumbawa District. The type of this study was associative study. The type of data used is quantitative data in the form of the results of respondents' answers obtained directly through a questionnaire. The population in this study were all BUMDes managers in Labuhan Jambu Village, Tarano Sub-District, Sumbawa District, totaling 213 people, while the number of samples was determined using the Slovin formula. The calculation results show that the number of samples is 68 people. All data that has been collected will then be processed using the SPSS program. SPSS output in the form of results will be analyzed and interpreted using simple linear regression analysis techniques, partial parameter hypothesis testing (t test), and the coefficient of determination test (R2). The results showed that BUMDes human resources had a positive and significant effect on the economy of Labuhan Jambu Village, Tarano Sub-District, Sumbawa District. The ability of BUMDes human resource variables to explain changes in economic variables in the village of Labuhan Jambu, Tarano Sub-District, Sumbawa District is 61.4%, while the remaining 38.6% is influenced by other variables outside this research model.


: The paper presents a wide analysis of the literature on the modified blow molding process with simultaneous stretching of PET material for storing hot filled drinks. The hot fill process is an in expensive conventional filling technology for high-acidity products (pH < 4.5). It allows certain drinks (sensitive beverages such as fruit and vegetable juices, nectars, soft drinks, vitaminized water) to be stored at ambient temperature without the need for chemical preservatives. The primary feature of the bottles used in the hot fill process is their temperature stability, i.e. the ability to retain the shape of the bottle at the filling temperature. From a mechanical point of view, the thermal stability of PET [poly(ethylene terephthalate)] bottles manufactured by the ISBM (injection stretch blow molding) pro cess is determined by the mechanical and thermal response of the blown preforms. From a microscopic point of view, the strongest influences on the mechanical and thermal properties of PET bottles are the orientation and crystallization processes. From a technological point of view, the properties of PET bottles after manufacture by the stretch blow molding process is mainly determined by the initial struc ture of the PET preform, the geometry and temperature distribution of the preform, the geometry of the blow mold, the temperature of the blow mold and its distribution in various parts of the mold and technological parameters of the blow molding process.


A technique is presented for obtaining approximations to the transfer function of a plant (by modelling the plant's impulse response by a linear combination of orthonormal functions) so that the steady-state responses of the plant and its approximation are the same for constant input. An example is given.


T authors retract this article on the basis that all of the characterization data were consistent with the proposed structure of the ligand being a 2:2 product of the reactants, but subsequent work showed that in fact it is a 1:1 product. Thus, all the solution chemistry and interpretations in the original publication were based on an incorrect assumption of the ligand structure. The corrected structure and related data are being published concurrently with this retraction notice, in an article entitled "Diand Trivalent Metal-Ion Solution Studies with the Phosphinate-Containing Heterocycle DEDA-(PO)", DOI: 10.1021/acs.inorgchem.7b01117. The original article was published on January 31, 2002 and was retracted on August 15, 2017. Retraction


[Objective]To study the factors influncing the model of unpaid blood donation and improve persistent development of regulation on unpaid blood donation.[Methods]With self-designed questionnaire,the survey was carried out among 5 012 random samples including unpaid blood donors,planned and orgnized unpaid blood donors and people without blood donation.[Results]The action of unpaid blood donation was influnced by the factors such as understanding of knowledge about blood donation,attitude to blood donation,age,degree of education,income,occupation and family circumstance.[Conclusions]The measures that reinforcing leadership and enhancing the policy support,raising the consciousness and attitude of blood donors to blood donation,promoting the abilities of medical staffs will contribute to the establishment of unpaid blood donation model.


This 4-wave longitudinal study examined how starting teachers' retention intentions changed over three years. One-way repeated-measures analysis of variance (ANOVA) found a significant main effect of time on retention intention. Two-way ANOVA also showed a significant main effect of pre-teaching work experience, and years of work experience on retention intention. However, there was no significant interaction effect between time and pre-teaching work experience, and between time and years of prior work experience. These findings suggest that prior work experience in other professions and length of working years did not make a difference in starting teachers' retention intentions over time.


Mesoporous nanocrystalline MgO·Al2O3 powders with different MgO/Al2O3 molar ratios were synthesized by a new and simple sol–gel route using C3H6O (propylene oxide) as a gelation agent. The prepared powders were employed as a support for preparation of 10 wt% Ni catalysts in biogas reforming, for the production of synthesis gas. This simple sol–gel method led to the preparation of powders with high BET surface area in the range of 252.8–301.6 m2 g−1 depending on the MgO/Al2O3 molar ratio after calcination at 700 °C. The samples also exhibited narrow single modal pore size distributions in the mesopore region. The H2-TPR analysis revealed that increasing the MgO/Al2O3 molar ratio shifted the Tmax of the reduction peaks to higher temperature, indicating the lower reducibility of the prepared catalysts with high MgO content. The NH3-TPD also confirmed the increase in basicity of the prepared samples with increasing MgO/Al2O3 molar ratio. The prepared catalysts exhibited high potential as catalysts for biogas reforming with high stability, and the catalysts with higher content of MgO showed higher resistance against carbon formation.


The constant capacitance model was used to describe selenite-ophosphate and silicate-o-phosphate competition on synthetic goethite (a-FeOOH) and synthetic gibbsite (Al(OH),) by direct optimization of mixed-ligand adsorption data. The model assumes ligand exchange mechanisms for selenite, o-phosphate, and silicate adsorption on oxide surfaces. The computer program, FITEQL, was used to fit intrinsic surface complexation constants to the competitive adsorption data. Values for the intrinsic protonation-dissociation constants, surface capacitance density, surface site density, and specific surface area had been determined previously. The constant capacitance model was able to represent competitive anion adsorption for selenite-o-phosphate over the pH range of 4 to 10 and for silicate-o-phosphate from pH 5.5 to 9.5. The fit to the experimental data using the mixed-ligand approach was much better than that obtained by prediction from single anion systems. The intrinsic surface complexation constants for o-phosphate adsorption were found to be dependent upon the surface composition of the adsorbent oxide. We suggest that this composition dependence is due to heterogeneity of surface adsorption sites. Our findings suggest the utility of mixedligand modeling for describing anion competition reactions using direct optimization of competitive adsorption data. Additional Index Words: o-phosphate adsorption, selenite adsorption, silicate adsorption, ligand exchange, FITEQL. Goldberg, S., and S.J. Traina. 1987. Chemical modeling of anion competition on oxides using the constant capacitance model-mixedligand approach. Soil Sci. Soc. Am. J. 51:929-932. T CONSTANT CAPACITANCE MODEL (Stumm 6t al., 1980) is a chemical model that describes anion adsorption by a solid phase, explicitly defines surface complexes and chemical reactions, and includes the effect of the pH variable on adsorption. Previously, this model has been used to describe specific adsorption of orthophosphate (o-phosphate), silicate, selenite, and arsenate anions by Al and Fe oxide minerals (Sigg and Stumm, 1981; Goldberg and Sposito, 1984a; Goldberg, 1985, 1986). 1 Contribution from the U.S. Salinity Laboratory, USDA-ARS, 4500 Glenwood Drive, Riverside, CA 92501, and the Dep. of Agronomy, Ohio State Univ., Columbus, OH 43210. Received 11 Dec. 1986. 2 Soil Scientist (Riverside) and Assistant Professor Soil Physical Chemistry (Columbus), respectively. OSU-OARDC Journal Article no. 43-87. Implicit to the use of the constant capacitance model is the assumption that anion adsorption occurs as an exchange reaction between an aqueous ligand and a surface hydroxyl group which can be described as SOH(s) + HvL°(aq) = SH,,L+ " '>(s) + H2O + (x y l)H(aq) [1] where 0 1, the adsorption of the ligand can no longer be thought of as a binary exchange reaction since the adsorption of each species of H,.L~ + , for 0 < y < x must be considered. In principle, the adsorption of the anion H,L~ + l0 represents a competitive exchange reaction between x species of anion and the hydroxyl groups bound to the mineral surface for a total of x + 1 anionic components. In practice, the adsorption of a polyprotic ligand will be limited to a binary or at most a ternary exchange reaction since no more than two species of a given polyprotic ligand are generally present in solution at any specific pH value. Recent analyses have tested the ability of the constant capacitance model to predict competitive adsorption by goethite in ophosphate-selenite, o-phosphate-silicate (Goldberg, 1985), and o-phosphatearsenate systems (Goldberg, 1985, unpublished results), by using model parameters obtained from separate studies of o-phosphate, selenite, silicate, and arsenate adsorption alone. Whereas the model was able to describe qualitatively the adsorption competition between each set of polyprotic anions, quantitative prediction was lacking in that o-phosphate adsorption was overestimated considerably while adsorption of the competing polyprotic ligand was underestimated. Goldberg (1985) suggested that the inability of the model to describe these anion competition data might be due to site heterogeneity. However, Chu and Sposito (1981) have shown that the exchanger-phase activity coefficients for n + 1 component exchange systems 930 SOIL SCI. SOC. AM. J., VOL. 51, 1987 Table 1. Numerical values of intrinsic surface complexation constants, t 100 Goethite-C Goethite-E Gibbsite-B Selenite-o-phosphate competition


In knowledge economy era, in-depth study of the basic role of protection of the intellectual property to promote science and technology progress has outstanding academic and practical significance. In the legal system of rights on the basis of right balance concept, and on the consensus of the deep understanding of China's economic and social structure and legal culture, and on the basis of reasonable adoption of international standards, we must establish the basic national policy which adapts to China's situation to protect China's intellectual property, and formulate a unified intellectual property code, and further improve the legal system relating to science and technology. Finally, the academia need to adopt the superior concept "right of knowledge" to direct the theoretical research and legal practice in the future, and make right of knowledge as a prevalent right as social right.


This paper analyzes how a world financial meltdown developed out of U.S. subprime mortgage markets. It outlines how deregulatory initiatives allowed Wall Street to build an entire line of new, risky financial products out of raw materials the mortgage markets supplied. We show how further bipartisan regulatory failures allowed these same firms to take on extreme amounts of leverage, which guaranteed that when a crisis hit, it would be severe. A principle focus is the "Paulson Put"—the effort by the U.S. Treasury secretary to stave off high-profile public financial bailouts until after the 2008 presidential election. The paper shows how the Federal Home Loan Bank System and other government agencies were successfully pressed into service for this purpose—for a while.


Introduction Clozapine, the antipsychotic of choice for treatment-resistant schizophrenia, has a narrow therapeutic range and high interpatient variability in the dose-response relationship. Serum clozapine levels are essential both for therapeutic dosing and to monitor adherence. Use of venepuncture and prolonged result turnaround times with standard laboratory based methods for drug monitoring together contribute to the suboptimal use of clozapine. Objectives A novel portable point-of-care (POC) device has been developed to measure whole blood clozapine concentrations using an automated homogenous immunoassay. It is as accurate and reliable as standard laboratory methods but only requires a drop of blood obtained by finger prick and can produce a result in minutes. We pioneered clozapine POC testing in the acute inpatient setting during the outbreak of the COVID-19 pandemic. Methods We report on the use of POC clozapine testing in the management of 4 acutely psychotic patients with treatment resistant schizophrenia. Results POC testing offered a more practical, less invasive and quicker alternative to conventional methods for monitoring of clozapine levels. Near immediate availability of clozapine levels expedited clinical decisions and helped ensure safe clozapine prescribing to severely unwell patients in a time of crisis. By facilitating patients' early safe discharge from hospital, clozapine point of care testing also reduced length of hospitalisation. Conclusions Point of care monitoring of other psychotropic medications in addition to clozapine brings about the prospect of personalised precision medicine for patients with severe mental illness, both in the acute setting and in the community.


Scholarly discussions of contemporary Chinese industrial relations (IR) have become relatively less substantive. This is in line with what has been happening recently in China's workplaces – fewer high profile work stoppages and the gradual improvement of migrant workers' terms and conditions in urban factories. With authorities tightening the control of autonomous worker resistance and non-government labour organizations, there is less excitement about IR in the world's largest emerging economy. Yet serious studies, such as The Emerging Industrial Relations of China, are a constant reminder that, first, investigations of China are still at an early stage and, second, more researchers are emerging to survey the country's changing economy and its impact on work and employment.


While near-infrared reflectance instruments are best known for their ability to rapidly analyze powdered solid samples, some manufacturers have provided the means to measure liquid samples as well. Unfortunately, liquid-analysis accessories are often cumbersome and expensive. A typical accessory requires a relatively large volume of the sample (on the order of milliliters) and complex purge/fill and wash cycles to prevent clogging. If clogging does occur, cleaning can be difficult. The thermostatically controlled heating cycle only adds to a total analysis time already extended by the other operations.


This article is the second summarising the main findings and conclusions of the review of the role(s) and responsibilities of infection prevention and control nurses (IPCN) commissioned by the Department of Health (England) in 2000. It describes the activities that form the core work of IPCN, discusses the strengths and constraints of the current role and makes suggestions for the future development of IPCN roles within the Health Protection Agency (HPA) and Primary Care Trusts (PCT).


This paper is aimed at analyzing the impact of COVID-19 on the Chinese online video industry. The hypothesis is that since people had more time to spend on leisure during the quarantine, the online video industry should be positively affected. Using methods such as collecting data from consulting firm's research reports, analyzing news events, and summarizing evidence from security firm's capital market research reports, I concluded that the pandemics did bring a short-term increase in people's attention to the online video industry, opened up new opportunities for creative business models, yet also posed potential threads shall the virus strike again in the future.


The authors' aim in the following study is to contribute to the assessment of the seismic hazard of historical
cities. From this preliminary analysis the general characteristics of the seismicity affecting Florence and the
evaluation of its seismic hazard may be deduced. Florence is a > city of world tourism, and its extraordinary
artistic value and its ability to be utilized constitute a great economic resource. From this perspective,
the authors have tackled some aspects of its urban features (demography and main building types, successive
phases in the growth of the city, etc.), aimed at the pooling of information as a basis for further, more specific
analyses of seismic risk. The study is based on a review of 131 seismic events of potential interest for the
site of Florence from the 12th century. In the case of each of these earthquakes, it was possible to verify the
real seismic effects sustained, and thus to assess the seismic intensity on the site. This also enabled the limits
in the application of the standard attenuation laws of to be checked. Of all the earthquakes analyzed. those
which caused the greatest effects on the urban area have also been identified: namely, the earthquake of
28 September 1453. and those of 18 May and 6 June 1895, both with Io=VIII MCS. From their overall
analysis the authors have further extrapolated the necessary data to statistically evaluate the probabilities of
any future earthquake occurring, according to intensity classes.


The study aims to identify the requirements of effective manufacturing and the extent of commitment by these requirements, from the studied company to ensure the achievement of the competitiveness in this company.
       To achieve the purposes of the study some hypotheses were developed. (40) form  of questionnaire were  distributed on the  staff of  the General Company for the manufacture of medicines and medical supplies in Samarra city , (38) from them were  recovered .hypotheses were  tested using correlation and  contrast analysis to  diagnosis the impact and correlations between surveyed variables.
      The study found a set of conclusions, most notably, great importance to the requirements of effective manufacturing were given from the employees of the studied company and also to the dimensions of minimum cost and excellence in their company.
      In the light of the conclusions, the study gave a set of recommendations   including: the necessity of adoption of the requirements of effective manufacturing and dimensions of minimum cost and excellence in the studied company, because the company could achieve the competitive advantage depending upon them.


This research aims at outlining the opinions of elementary school teacher candidates on the Primary School Social Studies Teaching Program in relation to Program's suitability to train problem solving and decision making abilities. Problem solving and decision making are parallel abilities since they both have common specifics. In order to realize the Program in practice, it is important for teacher candidates to recognize their abilities on problem solving and decision making. In this research, survey method has been used. Examples are composed of 128 students studying in Marmara University Ataturk Faculty of Education, Elementary Education Department. In this research triple likert type scale which is valid and reliable is used. Data obtained from this research is analysed through arithmetic average, standard dialect, t-test and varyans analysis. According to the results of the survey, teacher candidates consider the Program effective for training problem solving and decision making abilities. SUMMARY Purpose and significance: This research aims at outlining the elementary school teacher candidates' opinions on the Social Studies Teaching Program regarding its suitability to train problem solving and decision making abilities. Determining teacher candidates awareness levels toward these skills will be beneficial in assessing educational curriculum and implications. Methods: Survey method is used in this research. Examples are composed of 128 students who are studying in Marmara University Ataturk Faculty of Education, Elementary Education Department. In this research triple likert type scale which is valid and reliable is used. Results: While determining the opinions of elementary school teacher candidates on the effectiveness of the on training problem solving and decision making abilities, clauses are given vice versa points and arithmetic average is calculated to be 2,55. Through the t-test analysis, it's discovered there is a significant difference in favour of females, while determining the opinions of the teacher candidates', on the effectiveness of the Social Studies Teaching Program in relation to training problem solving and decision making abilities according to gender (p .05). At the end of the t-test analysis between the results on opinions of the teacher candidates on the effectiveness of the Social Studies Teaching Program regarding to developing problem solving and decision making abilities and analysing the levels of problem solving and decision making, a significant difference found favour of levels of problem solving and decision making (p<.05). Teacher candidate opinions on the effectiveness of the Social Studies Teaching Program in relation to train problem solving and decision making abilities, substantially differ from a factor to develop effectiveness to gain problem solving abilities (p<.05). Discussion and conclusions: The analysis appears that elementary school teacher candidates find the Social Studies Teaching Program effective in means of abilities subject to this research. The teacher candidates who found the Social Studies Teaching Program effective, suggested that the program can develop problem solving and decision making abilities; however the teacher candidates who don't find the Program effective suggest the contrary. This research shows that where elementary school teacher candidates find the Program effective to train these two abilities. The findings of Kan (2006) in his master thesis called "Consideration of Student Opinions on Effects of 5 th Grade Lessons on Developing the Abilities Envisaged in the New Elementary Education Program" showed parallelism with the current research. Kan reported that 5 th grade students found Social Studies Teaching Program effective in developing problem solving and decision makings skills. In addition, it's confirmed that female teacher candidates find the Social Studies Teaching Program effective in developing such abilities by the outcome of this research and the master thesis conducted by Kan (2006) and the article "Consideration of Math Teacher Candidates' Opinions on Application of Teaching on Students" drafted by Inan and Ozgen (2008). The result in the article called "Consideration of School Teachers' Ability to Gain Thinking Methods in Social Studies Lessons" drafted by Gelen (2002) shows the teacher candidates find themselves effective on training these two abilities.


The authors deserve high appreciation for their comprehensive approach to the subject (1). The clinical relevance demands, however, that the following items are specified to some extent:

The authors state that during pregnancy diabetic retinopathy can deteriorate by up to 55%. This (maximum) value should be put in perspective in view of the specific treatment conditions in Germany.

Among the risk factors for deterioration of diabetic retinopathy the authors cite the regular blood glucose monitoring required before pregnancy. 94.8% of all women with type 1 diabetes receive intensified conventional treatment (ICT) which requires regular blood glucose monitoring. This means that almost every woman with type 1 diabetes who is receiving intensified conventional treatment runs the risk of deteriorating. The parameter "regular blood glucose monitoring before pregnancy" is therefore no sufficiently predictive factor.

The proposal to prefer bevacizumab (complete antibody) to ranibizumab (Fab fragment) is not justified, as the literature reports miscarriages during bevacizumab treatment. In the cited article, it is early pregnancy, but not the anti-VEGF antibody that causes miscarriages. Therefore, any anti-VEGF therapy should be prohibited during early pregnancy. Thus far, no VEGF inhibitor has been approved for the treatment of proliferative diabetic retinopathy.

The recommendation to examine the retinal fundus one year after delivery in women with type 1 diabetes and diabetic retinopathy who are closely monitored is not supported by the guidelines. Since the justification for close monitoring is pre-existing retinopathy, the post partum screening intervals should be conducted according to the level of pre-existing retinopathy (mild-moderate non-proliferative diabetic retinopathy 6 months; severe non-proliferative diabetic retinopathy: 3 months).


Purpose
The purpose of this study is to investigate a new and innovative sandwich material evaluating its capability for use in space habitat structural components in deployable and foldable configurations. The main habitat requirements were considered in the preliminary design of a typical space outpost, proposing a preliminary architecture.

Design/methodology/approach
The stiffness properties of the innovative sandwich (MAdFlex ®) were evaluated using numerical and experimental investigations. Four-point bending tests were performed for complete sandwich characterization. Numerical FE simulations were performed using typical material properties and performance. The application to a space habitat main structure as a basic material has also been discussed and presented.

Findings
MAdFlex basic stiffness performances have been determined considering its double behavior: sufficiently stiff if loaded in a specific direction, flexible if loaded in the opposite direction and enhanced folding performance. Successful application to a typical space habitat confirms the validity and convenience of such a material in designing alternative structures.

Research limitations/implications
The innovative material demonstrates wide potential for structural application and design in demanding space situations under operating conditions and in stored ones at launch.

Practical implications
Several simple deployable structural components can be designed and optimized both for the space environment and for the more traditional terrestrial applications.

Social implications
Simplification in structural design can be derived from deployable low-weight items.

Originality/value
Innovative customized material in sandwich configuration has been proposed and investigated with the aim to demonstrate its potentiality and validity in alternative design architecture.


Maritime boundary, like territorial or land boundary, is a politically sensitive subject, because it affects a state's sovereign rights concerning the fisheries, hydrocarbons and other resources as well as uses of the sea. This sensitivity is manifest in the issue of delimitation of maritime boundaries between India and Bangladesh. Bangladesh, having failed to resolve the dispute diplomatically, has invoked Annex VII mandatory arbitration procedures, entailing binding decision, to seek judicial settlement of the dispute against India. Currently, arbitration proceedings are going on between India and Bangladesh at the Permanent Court of Arbitration, The Hague, for the delimitation of their maritime boundaries under the UNCLOS, 1982. This paper provides an overview and analysis of the legal aspects of the India-Bangladesh maritime boundary dispute. Bangladesh's 'nonflexible' approach in resolving the dispute is primarily driven by its desperation to benefit commercially by exploiting potential hydrocarbon resources in the Bay of Bengal, which ignores both facts as well as the applicable law. Therefore, arguments put forth by Bangladesh to buttress its maritime claim may boomerang in legal scrutiny and make it a loser in legal battle with India.


I addressed whether competition was likely to occur between sympatric mountain sheep (Ovis canadensis canadensis) and introduced mountain goats (Oreamnos americanus). I examined direct interactions between mountain sheep and mountain goats during a study of habitat selection and activity patterns for the species from 1981 through 1986. 1 observed 107 interference interactions; 39 (36.5%) resulted in apparent deterrence of sheep from some resource. I applied these data to a conceptual model of interference competition derived from information from other studies and competition theory. The 39 interactions provided an approximate point on a negative effects continuum where negative effects are greater for 1 species than for the other. Introduced or re-introduced wild ungulates potentially raise management challenges if their populations continue to increase and their distributions expand.


Millijoule-scale multicycle terahertz (THz) sources have recently gained interest for applications where high-peak-fields and narrow bandwidths can produce unique results, such as linear and nonlinear spectroscopy [1], control of matter [2], and compact electron acceleration [3]. Difference frequency generation (DFG) using periodically-poled lithium niobate (PPLN) is a very promising method for producing such pulses, due to the high nonlinear coefficient of lithium niobate and the tunability of the periodic poling. For optimized configurations of laser drivers and PPLN crystals, theoretical predictions show conversion efficiencies of 1% and higher can be reached [7]. Using Joule-scale optical pulses may thus make 10s of mJ multicyle THz pulses possible.


Biographies of two 17th-century female criminals, both celebrated in their day. These are the first editions published since the 17th century.


China's increasing participation in world affairs and the growing popularity of English as a lingua franca have made significant impact on Chinese society, culture and education. As such, considerable research topics in relation to English require TEFL researchers' attentions. Additionally, higher education reform in China has created higher demand on academics by stressing research as an important element in academics' assessment. Recurrent rhetoric in the field of TEFL also calls on practitioners to theorise their practice. All these practical needs and theoretical arguments point to the necessity and significance of TEFL academics' engagement in research. To find out whether Chinese TEFL academics' research meet the new demand on them, a survey of TEFL academics at three Chinese higher institutions was conducted. One hundred eighty two of them provided valid responses which were analysed using SPSS. It was found that TEFL academics' research productivity in each category of research products was quite low. Large percentages of them did not produce any item in the investigated categories of research. They were least productive in conference papers and research products at the national level. However for these least productive categories, there were highly-productive TEFL academics. The categories of research where the TEFL academics were found relatively productive were non-core journal articles and provincial projects. The findings suggest that it is necessary and urgent for Chinese TEFL academics to enhance their research productivity to be able to meet the demand that new era has rendered.


By analysis of the present status of explosion protected electrical equipments used in drilling site,some factors caused out-of-service of explosion protection property for the Ex equipments are found out.So result,it provides the basis of enhancing the safe reliability for these equipments used in oil field and reference as assembly,maintenance and management of equipments in site.


K. Noorin Rahila 1 , L. Nivedha 2 and R. Narayani 3 and Dr. W. Aisha Banu 4 . 1. UG Students, CSE Department, 2. B.S.A.Crescent Institute of Science and Technology. 3. Assistant Professor Sr.Gr, B.S.A.Crescent Institute of Science and Technology. 4. Professor,, B.S.A.Crescent Institute of Science and Technology. ...................................................................................................................... Manuscript Info Abstract ......................... ........................................................................ Manuscript History


This paper presents the temperature distribution of the oil-immersed self-cooled transformer with radiator performed by coupled magneto-fluid-thermal analysis. Particularly, 3D temperature distribution of cooling oil and sub-components under the natural convection is obtained by computational fluid dynamics analysis, while heat sources are predetermined by magnetic field analysis using F.E.M. The predicted temperature distribution of the power transformer model is compared with the measured data for verifying the validity of the proposed analysis.


The Medical Journal of Australia ISSN: 0025729X 15 October 2012 197 8 HIDDEN-467 ©The Medical Journal of Australia 2012 www.mja.com.au Lessons from Practice riage or neonatal disease.2 L. m host via enterocyte and ma whereby it continues to spread bacteraemia after cell lysis.3 Thr avoids the humoral immune sys cell-mediated immunity is crit cumstances where cell-mediat Invasive listeriosis is an uncommon cause of meningitis associated with the intracellular gram-positive rod Listeria monocytogenes. L. monocytogenes is widely distributed in the environment and is a common isolate from soil, vegetation and animals. Primarily a foodborne pathogen, L. monocytogenes is able to grow at refrigeration temperatures and is associated with uncooked refrigerated goods such as coleslaw, pâté, soft cheeses and delicatessen foods.2 Infection can either be non-invasive, with a self-limiting febrile gastroenteritis, or invasive, with either frank sepsis (often with central nervous system infection in adults) or pregnancy-associated infection resulting in stillbirth, miscaronocytogenes invades the crophage phagocytosis, intracellularly and during ough cell-to-cell spread, it tem; and hence, an intact ical to host defence. Cired immunity is impaired, such as with treatment with prednisolone or fludarabine, are well documented predisposing factors.4 In recent years, case reports have also implicated monoclonal antibodies against tumour necrosis factor-alpha (TNF-), including infliximab, etanercept and adalimumab. TNF- stimulates macrophage differentiation, phagocytosis and bacterial killing, and has been shown in mice to be critical to the early immune response.3 Accordingly, epidemiological studies have described the rate of listeriosis in those taking infliximab and etanercept to be 20–30 times and three times greater than that in the general population, respectively.5 Five cases of listeriosis in patients who were taking or had recently been taking adalimumab have been reported, three in patients with rheumatoid arthritis and two in patients with Crohn's disease.6-10 Additionally, most reported cases have occurred in patients receiving concurrent immunotherapy with steroids, methotrexate, azathioprine and/or mercaptopurine.9,11 Highlighting the emerging evidence of association between TNF- antagonists and listeriosis, the United States Food and Drug Administration updated the Boxed Warning on the entire class in 2010 to include the risk of infection with L. monocytogenes.12 with confusion, fluctuating expressive dysphasia, frontal headache and fever, preceded by 12 hours of lethargy and myalgia.


The article presents the analysis of the influence of standard shifts in crane loads on a supportive structure. It has been shown that the valid standards' conditions were established without carrying out suitable tests. The presented results of the experimental research have not confirmed the standards in terms of the occurrence of forces.


A new method for the enantioseparation of phenylalanine by capillary electrophoresis with conductive detection was developed.The enantiomer of phenylalanine were baseline separated within 8 min under the following experimental conditions: uncoated fused silica capillary,2 mmol/L NaAc+2 mmol/L HAc+0.5 mmol/L Cu2+(pH 4.0) as running buffer,and 15 kV separation voltage.The effects of running buffer,pH,the concentration of chiral selector,separation voltage and injection time were investigated.The mechanism of enantionseparation was also discussed.


Accounting for the traumatisms of the First World War constituted a crucial moment in the history of psychoanalysis. The study of traumatic neuroses in times of war had repercussions on psychoanalytical theory and consequences for Freudian politics at the beginning of the 1920s. This clinical category allowed Freud to approach the phenomenon of repetition differently, as a repetition of displeasure, and to lay the foundations for a new dualism of the drive. It also led him to formulate advances in the psychoanalytical theory of anxiety, narcissism, and identification. Freud was summoned as an expert witness before a commission of the Austrian Parliament, in charge of examining the grievances of veterans who had undergone therapies that made use of corporal punishment. He had to give his opinion on the exemplary case of Lieutenant Kauders. This soldier, suffering from post-traumatic symptoms, was suspected of faking symptoms and was hospitalized in the clinic of Professor Wagner-Jauregg to undergo electric shock therapy, which was a common solution at that time. In his expertise, Freud took the lieutenant's defense, affirming the psychic dimension of the trauma. He insisted that the therapeutic application of psychoanalysis on a large scale was justified; the work with traumatized soldiers led by his students had already proved so. The development of psychoanalytic institutes, modeled after the Berlin Polyclinic, founded in February 1920, was the backdrop for this argument and the political aim of a psychoanalysis for all.