Background: Coronavirus disease 2019 (COVID-19) has demonstrated a variety of presentations and clinical complications, among them coinfection of pneumonia with the mold Aspergillus spp. Patients at risk for invasive disease include transplant recipients and those with prolonged neutropenia, immune disorders, cystic fibrosis, and steroid use. There have been recent descriptions of coronavirus disease–associated pulmonary aspergillosis (CAPA). An outbreak investigation into a cluster of Aspergillus fumigatus infections in a health system intensive care unit uncovered a community-onset (CO) increase in CAPA. Methods: A multidisciplinary outbreak investigation was conducted evaluating sources of contamination, completion of construction projects, and changes in clinical processes. Retrospective chart review was done for the prior 18 months and incidence density rates for Aspergillus infections from June 2019 through December 2020 were calculated per 10,000 patient days, stratified by unit, specimen source, and coinfection with COVID-19. Data were linked with all positive and negative COVID-19 tests performed by the health system's regional laboratory from March to December 2020. Healthcare-onset (HO) classification was based on infections identified ≥7 days after admission. Statistical analysis was calculated with significance at p < 0.05. Results: Over the last 18 months, 82 patients were identified positive with Aspergillus cultures; of which 10 (12%) met CAPA definitions. Aspergillus fumigatus was the most common species and accounted for 62% of samples, followed by Aspergillus niger (17%). Median rates of HO Aspergillosis were 0.45 cases per 10,000 patient days, whereas the median total rates of infection were 1.97 cases per 10,000 patient days. Rates of CAPA coincided with COVID-19 hospitalization rates. In the spring and fall, surges of COVID-19, the rate ratio of CAPA to COVID hospitalized infections per 10,000 patient days, ranged from 0.006 to 0.015. Once CAPA infections were adjusted for, rates of CO Aspergillus remained high, whereas HO cases suggested baseline acquisition. Conclusion: This study outlines rates of CO aspergillosis as well as CAPA rates coinciding with the healthcare system's spring and fall surges of COVID-19 hospitalizations. Despite the determination that this was not a hospital-acquired cluster, the investigation revealed some areas for opportunity in construction processes along with maintaining coverage of all patient supplies to reduce the risk of contamination. Funding: No Disclosures: None Figure 1.


The 1,4-dihydropyridine receptor (DHPR) of the voltage-dependent Ca channel has been purified from transverse tubular membranes of skeletal muscle. Curtis and Catterall have shown that it consists of three polypeptides of 160,000 daltons, 50,000 Da, and 32,000 Da and that under reducing conditions the apparent molecular weight of the 160,000 Da subunit shifted to 130,000. Borsotto et al. have identified three polypeptides of 142,000 Da, 33,000 Da, and 32,000 Da in their preparation of the dihydropyridine receptor. Furthermore, they have shown by immunoblotting with polyclonal antibodies that the 142,000 Da and 32,000 Da subunits are produced by the reduction of a 170,000 Da polypeptide. We report here the identification and characterization with monoclonal antibodies (MAb) of an additional high molecular weight subunit of the DHPR which is distinct from that described by Curtis and Catterrall and Borsotto et al. Monoclonal antibodies capable of specifically immunoprecipitating the [H]PN200-110-labeled DHPR of rabbit skeletal muscle were produced by immunizing BALB/c mice initially with skeletal muscle triad vesicles followed by booster immunizations with purified DHPR from skeletal muscle triads. Hybridoma supernatants were screened for the production of anti-DHPR antibodies with an immunodot assay. Supernatants that reacted positively against the partially purified DHPR were then tested for their ability to immunoprecipitate the [H]PN200-110-labeled receptor from digitonin-solubilized triads (see TABLE 1). All three MAbs (IIC12, IIF7, IIID5) that were capable of immunoprecipitating the DHPR recognized a protein with an Mr of 170,000 on nitrocellulose transfers of skeletal muscle triads and transverse tubular membranes separated on sodium dodecyi sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions (FIGURE la). Wheat-germ agglutinin (WGA) peroxidase stained a 175,000 Da protein on similar nitrocellulose transfers. Neither the 170,000 Da polypeptide nor the 175,000 Da polypeptide was detected in light sarcoplasmic reticulum vesicles, a preparation devoid of DHPR. Under reducing conditions, the Mr of the 170,000 Da


<abstract>
The main purpose of this paper is to use elementary and analytic methods to study the calculating problem of one kind of Gauss sums and obtain an exact computational formula for it.
</abstract>


This report is an initial exploratory scoping review prepared for Chaplain Dan Hynes (Department of Spiritual Health and Wellbeing, Joint Health Command, Australian Defence Force, Canberra, ACT, Australia) and Chaplain Mark Willis (Director General, Chaplaincy Branch, Royal Australian Air Force, Australian Defence Force, Canberra, ACT, Australia). Support for this report was provided by La Trobe University, Department of Public Health Participatory Field Placement Internship program (PHE3PFP).


A cDNA library from the skin of alpaca in china was constructed using the prokaryotic expression vector pet-32-a+.All the cDNA fragments are normalized by 1 % agarose gel,and the fragments below 400 bp were discarded.The digested vector was processed by dephosphorylase and the cDNA fragments were processed by phosphorylase.The positive recombination rate was 100 % examined by blue/white colony.The library capacity was 2.25×107.Randomly selected 7 positive clones were sequenced by Shaihai Sangon bio-engineering company using T7 terminator primer.Two ESTs related to the wool growth were obtained,which are S100 calcium binding A3 gene and high sulfur keratin-associated protein gene.


Lamium album L. (white dead nettle) is a plant widely used both in traditional and in folk medicine. In the scientific literature there is evidence of its broad-spectrum activity as astringent and anti-inflammatory agent, as well as a bacteriostatic and antispazmotik. This remarkable therapeutic effect was due to the wide variety of biologically active secondary metabolites of the plant. Mass collection of plants for commercial and medical purposes would jeopardize its natural populations. This requires comparison of the biological activity of extracts of plants cultured in vitro with those collected from natural deposits. In our previous studies we have demonstrated the potential antitumour activity of extracts of Lamium album L. On cell cultires. In this study, our attention was focused on the effect of extract from plants grown under different conditions on the cellular genome, the mitochondrial activity or the adhesion of normal and carcinoma cells. Our results indicate that, despite the poorer secondary metabolite composition, in vitro cultivated plants showed better antitumor


The authors introduce a general class of traffic models derived as perturbations of cell-transmission type models. These models use different dynamics in free-flow and in congestion phases. They can be viewed as extensions to cell transmission type models by considering the velocity to be a function not only of the density but also of a second state variable describing perturbations. The authors present the models in their discretized form under a new formulation similar to the classical supply demand formulation used by the seminal Cell-Transmission Model. We show their equivalence to hydrodynamic models. The authors detail the properties of these so-called perturbed cell-transmission models and illustrate their modeling abilities on benchmark cases. It is shown that they encompass several well-known phenomena not captured by classical models, such as forward moving disturbances. An implementation method is outlined to implement a perturbed cell transmission from a classical cell transition model.


The clinical need for an alternative to donor corneal tissue has encouraged much interest in recent years. An artificial cornea whether it be bio-engineered or a synthetic keratoprosthesis must fulfill the functions of the cornea it replaces: transparent, refractive surface, protection, non-immunogenic. A wide range of implants and biomedical devices have been developed in an attempt to correct corneal blindness. Limitation of existing biomaterials are evident when reviewing keratoprosthesis surgery complications. These include infection, intraocular inflammation, retromembrane formation, inadequate interface seal thus epithelial downgrowth and glaucoma. Attempts to improve healing in such cases have involved using various polymers or tissues to surround the optic. The successes and failures of synthetic prostheses that have been implanted in humans is discussed. More recently, the idea of a bio-engineered cornea has arisen. Tissue-engineering involves the manipulation of cells using in vitro techniques to create a composite tissue, which could then be implanted in vivo. Corneal equivalents have been reconstructed from corneal cell lines. They already have their potential uses in the biomedical world: as replacements for animals in toxicology testing and pharmacological studies, as well as in basic research into cell-cell and cell-matrix interactions of corneal wound healing. Current research is ongoing to determine if the bio-engineered cornea will have a role in corneal transplant surgery.


Low molecular weight N-succinyl-chitosans with different degrees of substitution were synthesized by controlling reaction temperature, reaction time, and the molar ratio of the low molecular weight chitosan to succinic anhydride. The structure of the low molecular weight N-succinyl-chitosan was characterized by infrared spectroscopy(IR), by which —COCH_ 2CH_ 2COOH was proved to be introduced to the —NH_ 2 of the low molecular weight chitosan. The moisture adsorption and moisture retention capacities of the low molecular weight chitosan derivatives with different degrees of substitution were investigated. The results indicate that the moisture adsorption and moisture retention capacities of the low molecular weight N-succinyl-chitosan increase with the increase of the degree of substitution. When the degree of substitution is greater than 38%, the derivatives have better moisture adsorption and moisture retention capacities than hyaluronic acid.


The Wavelet solution for boundary-value problems is relatively new and has been mainly restricted to the solutions in data compression, image processing and recently to the solution of differential equations with periodic boundary conditions. This paper is concerned with the wavelet-based Galerkin's solution to time dependent higher order non-linear two-point initial-boundary-value problems with non-periodic boundary conditions. The wavelet method can offer several advantages in solving the initial-boundary-value problems than the traditional methods such as Fourier series, Finite Differences and Finite Elements by reducing the computational time near singularities because of its multi-resolution character. In order to demonstrate the wavelet, we extend our prior research of solution to parabolic equations and problems with non-linear boundary conditions to non-linear problems involving KdV Equation and Boussinesq Equation. The results of the wavelet solutions are examined and they are found to compare favorably to the known solution. This paper on the whole indicates that the wavelet technique is a strong contender for solving partial differential equations with non-periodic conditions.Copyright © 2003 by ASME


Various measures were adopted to actively push forward the rural residential land readjustment in Zhejiang province,including the reconstruction of old village and relocation of fanners from the mountain in Lishui County,as well as the so-called Two Renovation Development in Haining County.Farmers who quit their house can be compensated through diverse options,such as constructing new houses at the same location or other places according to the land planning,choosing uniformly-built apartment,or buying social welfare house in the county or town with lower price,or even direcdy in cash.There are four kinds of dilemmas in the readjustment,i.e.(1)relocating village wholly or partially;(2)constructing after demolishment or demolishing after construction;(3)remaining the saved construction land quota in the village or sell the quota to the urban area;(4)reclaiming the former residential land into cultivated land or make a decision regarding the local conditions.The paper concludes with some suggestions for guiding the rural residential land readjustment.First,farmers should be authorized with diverse options according to local conditions. Second,the rural residential land readjustment should be implemented step by step under the guidance of a general planning.Third,the use of the saved construction land quota and the distribution of profits should be strictly regulated. Fourth,it is necessary to enhance the supervision in order to maintain the order of land administration in the rural area.


1. Huntington Library, MS HM 6131, 'A NARRATIVE; OR AN Historicall Account Of The most Materiall passages In the Life of John Rastrick', fos 1v–2r.


Tested the durability of concrete,systematically described the admixtures,admixture mechanism of action,characteristics and adaptability,summed up the control points of the durability of concrete construction technology,guiding significance of the concrete construction of the high-speed rail.


There is assumed to be a monotonic association between melatonin suppression and circadian phase resetting induced by light exposure. We tested the association between melatonin suppression and phase resetting in humans. Sixteen young healthy participants received nocturnal bright light (∼9500 lux) exposure of continuous or intermittent patterns, and different durations ranging from 12 min to 6.5 h. Intermittent exposure patterns showed significant phase shifts with disproportionately less melatonin suppression. Each and every bright light stimulus in an intermittent exposure pattern induced a similar degree of melatonin suppression, but did not appear to cause an equal magnitude of phase shift. These results suggest that phase shifts and melatonin suppression are functionally independent such that one cannot be used as a proxy measure of the other.


Deployment of optical fibre cable in limited space and in tight bend conditions demands reduced diameter optical fibre and cable with bend insensitive fibre. To address this need, optical fibre with 200 micron outer coating diameter instead of 250 micron for conventional fibre has been developed. This application note outlines various advantages of 200 micron fibre and its backward compatibility with conventional fibre. Bends like Magic Challenges in cable deployment in optical networks There are two major challenges in cable deployment in high capacity optical networks – limited space in distribution network and tighter bends in subscriber loop. To provide service to large number of subscribers, high fibre count optical fibre cables which can carry large volume of information is necessary in distribution network. Currently optical fibre cable is available with over 1000 fibres in a single cable. Although high fibre count cable is a solution to handle large volume of information, this option is not always suitable due to limited space in installed ducts as higher fibre counts generally increase the cable diameter. Installation of new ducts is an expensive & time consuming operation due to the large amount of civil work needed, and the need to get right of way approval from the government & other local bodies. At present, successful penetration of optical fibres into the local distribution networks depends on the development of small, flexible, lightweight and cost effective cables. In addition, cable blowing distances can be vastly increased using smaller and lightweight cables reducing deployment costs. Therefore, reduced diameter cables called 'micro cables' have become popular during duct and cable installation. To increase fibre count further in micro cables and to reduce cable diameter further such that micro-ducts can be used, a compact cable design is necessary. Compact cable design can be achieved by increasing fibre packing density, and reducing size of the cable elements and fibre. Tighter packing density and reduced size cable elements need fibre with less micro-bend sensitivity. Additionally, fibre with improved macro-bend sensitivity is essential to limit increase in optical power loss due to tighter bends in subscriber loop. Bend sensitivity improved ITU-T G.657 category single mode optical fibre (SMF) with reduced coating diameter is therefore the solution for compact cable design. A significant improvement in fibre density in optical fibre cables can be achieved by using bend insensitive 200 micron optical fibres. Figure 2 illustrates how compact cable design is achieved with 200 micron fibre. Diameter of a 72 fibre conventional cable with 250μm fibre is around 13.5 mm. In Micro cables, the diameter was reduced to around 9.4 mm for 288 fibre. With 200 micron fibre, 432 fibre cable can be produced with 8.6 mm outer cable diameter. Reduction in fibre cross-sectional area enables higher fibre count cables with smaller cable outer diameter. In 432 fibre micro cable, 24 fibres instead of 12 can be placed in a similarly sized loose tube. Although this type of design has higher packing density, it Optical fibre is used in all modern optical communications including long-haul, regional, access, and FTTX networks. An optical fibre is made up of three layers, namely, core, cladding, and coating. Light is guided down the centre of the fibre called the "core". The core is surrounded by an optical material called the "cladding" that contains the light in the core using an optical phenomenon called "total internal reflection." The fibre is coated by a buffer layer that protects it from moisture and physical damage. The buffer or "coating" is what one strips off the fibre for termination or splicing. More protection is provided by the cable which has the fibres and strength members inside an outer protective covering called a "jacket" or a "sheath." The fibre coating is made of a UV curable polymer called acrylate, which acts to protect the inner glass. Dual layered coating structures are generally applied, which use a low-modulus inner or buffer layer to cushion the fibre surrounded by a high-modulus outer coating to increase the flexural rigidity and distribute the lateral external forces. Glass cladding and outer coating diameter are standardised to 125 μm and 250 μm respectively in various international standards and recommendations. Standardisation of these two critical dimensions of silica glass optical fibre has ensuredcompatibility between optical networks across the globe. Currently, single mode optical fibre with a reduced 200 μm coating diameter and 125 μm cladding diameter is commercially available. The 125 μm cladding diameter ensures backward compatibility with existing optical network. Fig. 1 shows a comparison between 250 μm and 200 μm coated fibre. This reduced diameter optical fibre opens up options for producing cable with more compact designs allowing more penetration depth in access and FTTX networks. Figure 1: Schematic Cross sectional view of SMF


The invention discloses a novel tape adhering machine which comprises at least one tape adhering head and a base, wherein the tape adhering head comprises a main mounting plate a and an assorted mounting plate which is matched with the main mounting plate a; a tape fixing wheel and a cutting mechanism are arranged on the main mounting plate a; the tape fixing wheel is arranged at the top of the main mounting plate a for fixing a tape; the cutting mechanism is arranged at the lower part of the main mounting plate a; the cutting mechanism is provided with a cylinder to drive a prepressing module and a cutter to complete the tape adhering and cutting tasks; and the base is used for fixing the tape adhering head and conveying materials which are required to be adhered. The novel tape adhering machine utilizes the lever principle to complete the tape adhering and cutting tasks through a driving link which consists of the cylinder and a knuckle bearing, so the adhering efficiency is greatly increased, in addition, the structure of the tape adhering head is also correspondingly simplified, and the cost is lowered; and moreover, the novel tape adhering machine meets different specification requirements on the materials which are needed to be adhered, and the adhering effect is improved.


Objective:making use of Keypoint Myoelectricity Induced Potentiostat , we made a realtime monitoring to expert group, common clinical group and student group to do a half-quantitative research on rolling. Thus, the experiment can be a normalized support of rolling. Methods:Three being-tested groups rested for fifteen minutes firstly, avoiding psychological factor interference. Then according to traditional rolling hints on operation, every tester was manipulated twice, five minutes each time, making the realtime monitoring of electromyography signals. The two operations should be separated at the intervals of ten minutes to ensure identity and repeatability. Myoelectricity signals were mainly used to check up the movement unit potencial of biceps brachii, pronator teres and extensor carpi radialis longus.Results:In the rolling manipulation, the MUP amplitude of biceps brachii is between 2.60~6.47mV; the MUP amplitude of pronator teres is between 3.37~7.35mV; the MUP amplitude of extensor carpi radialis longus is between 3.68~8.31mV. Conclusions:On one hand, myoelectricity signals can make a realtime record of forearm muscle exerting situations of massage users; on the other hand, it can be reflected from the signals that if the students who majored in massage should enhance their technique practice to assure that technique will be regular, powerful and lasting.


We study measurable elements of a Riesz space E, i.e. elements e ∈ E \ {0} for which the Boolean algebra Fe of fragments of e is measurable. In particular, we prove that the set Emeas of all measurable elements of a Riesz space E with the principal projection property together with zero is a σ-ideal of E. Another result asserts that, for a Riesz space E with the principal projection property the following assertions are equivalent. (1) The Boolean algebra U of bands of E is measurable. (2) Emeas = E and E satisfies the countable chain condition. (3) E can be embedded as an order dense subspace of L0(μ) for some probability measure μ.


We characterized a sample of metal-oxide resistors and measured their breakdown voltage in liquid argon by applying high voltage (HV) pulses over a 3 second period. This test mimics the situation in a HV-divider chain when a breakdown occurs and the voltage across resistors rapidly rise from the static value to much higher values. All resistors had higher breakdown voltages in liquid argon than their vendor ratings in air at room temperature. Failure modes range from full destruction to coating damage. In cases where breakdown was not catastrophic, subsequent breakdown voltages were lower in subsequent measuring runs. One resistor type withstands 131 kV pulses, the limit of the test setup.


There are two types of Gauss diagram formulas for Vassiliev invariants. One type is introduced by M. Polyak and O. Viro together with various notations (PolyakViro type formulas); the other type is our formulas which are derived from the Kontsevich integral in a previous paper. In this paper, we derive Polyak-Viro type formulas from our formulas.


This work presents planning and delivery comparison of linac-based SRS treatment techniques currently available for single lesion cranial SRS. In total, two dedicated SRS systems (Novalis Tx, Cyberknife) and a HI-ART TomoTherapy system with six different delivery techniques are evaluated. Four delivery techniques are evaluated on a Novalis Tx system: circular cones, dynamic conformal arcs (DCA), static non-coplanar intensity modulated radiotherapy (NCP-IMRT), and volumetric modulated arc therapy (RapidArc) techniques are compared with intensity modulation based helical Tomotherapy on the HI-ART Tomotherapy system and with non-isocentric, multiple overlapping based robotic radiosurgery using the CyberKnife system. Thirteen patients are retrospectively selected for the study. The target volumes of each patient are transferred to a CT scan of a Lucy phantom (Standard Imaging Inc., Middleton, WI, USA) designed for end-to-end SRS QA. In order to evaluate the plans, several indices scoring the conformality, homogeneity and gradients in the plan are calculated and compared for each of the plans. Finally, to check the clinical deliverability of the plans and the delivery accuracy of different systems, a few targets are delivered on each system. A comparison between planned dose on treatment planning system and dose delivered on Gafchromic EBT film (ISP, Wayne, New Jersey, USA) is carried out by comparing dose beam profiles, isodose lines and by calculating gamma index.%%%%Cette etude presente la planification et la comparaison de livraison de doses de les techniques de traitement par accelerateur lineaire (linac) a base de radiochirurgie stereotactique (RCS) actuellement disponibles pour la RCS des lesions crâniennes uniques. Au total, deux systemes RCS (Novalis Tx, Cyberknife) et un systeme HI-ART TomoTherapy avec six techniques differentes de livraison de doses sont evalues. Trois techniques de livraison de doses d'un systeme Novalis Tx sont evalues: arcs dynamiques conformationnelles, radiotherapie avec modulation d'intensite statique non-coplanaire et les techniques de therapie volumetrique par arc module (RapidArc) sont comparees avec la tomotherapie helicoidale par modulation d'intensite sur le systeme HI-ART TomoTherapy et la radiochirurgie robotique non-isocentrique a multiples chevauchements du systeme CyberKnife. Treize patients sont retrospectivement selectionnes pour l'etude. Les volumes cibles de chaque patient sont transferes sur un scan tomodensitometrique d'un fantome Lucy (Standard Imaging Inc, Madison, WI, Etats-Unis) concu pour l'assurance qualite des systemes RCS. Afin d'evaluer les plans de traitements, plusieurs metriques de notation de conformalite telles que l'homogeneite et les gradients du plan de traitement sont calculees et comparees pour chacun des plans. Enfin, dans le but de verifier la faisabilite de livraison clinique des plans de traitements et la precision de livraison des differents systemes, quelques cibles sont delivrees sur chaque systeme. Une comparaison entre la dose prevue sur…


Pippa Oakeshott recommends referral to genitourinary medicine (GUM) for partner notification,1 but we would question how feasible this would be in the context of a national …


This study seeks to delve into the potential benefits and implications of utilizing computational chemistry-based learning media within a classroom environment, particularly when coupled with the STAD type cooperative learning model. The central focus of this research is to determine the effect of this innovative learning approach on student learning outcomes and motivation, especially when applied to the intricate subject of forces between molecules. This topic is of great relevance given the inherent complexities associated with intermolecular forces. The population under consideration for this research consisted of grade X students attending high schools in the bustling city of Medan. Out of several classes, a detailed examination was conducted on two specific classes: X IPA 3 and X IPA 5. These chosen classes represented a balanced sample size of 72 students, with each class containing 36 students. To ensure the rigor and validity of this study, the research instruments employed were twofold. Firstly, test instruments, presented as 20 multiple choice questions to gauge the student's grasp on the subject. Secondly, a non-test form containing 30 statements to evaluate qualitative factors such as motivation and perspective. To maintain the credibility of the research, the quality of the instruments was thoroughly scrutinized using various parameters like validity, reliability, question difficulty level, and differentiating power. These parameters ensured that only the most effective questions were selected as research instruments. Preliminary data analysis techniques showed promising results. In evaluating learning outcomes through hypothesis testing, the t-count> t-table value stood at 5.03>1.666. Similarly, the results for learning motivation hypothesis testing produced a t-count> t-table value of 3.12>1.666. From this preliminary data, it becomes evident that there is a positive effect of computational chemistry-based learning media using the STAD type cooperative learning model on student learning outcomes and motivation concerning the subject of forces between molecules.


ABSTRACT This article discusses the secular volatility of output, inflation, the exchange rate, and poverty in Argentina. Inflation, currency devaluation and a wide gross domestic product (GDP) cycle have been recurrent problems in Argentina for several decades. The literature has extensively discussed those issues from different viewpoints. This study focuses on a relatively unexplored theme that may contribute to a partial explanation. It deals with the continuous tendency to equalize different profitabilities resulting, in turn, from remarkably different sectoral purchasing power parities. Thus, for any given exchange rate, an incessant tendency toward the equalization of profitabilities generates opposing inflationary and devaluatory pressures. The resulting inflation-devaluation cycle feeds income redistribution, GDP fluctuation, real exchange rate instability, and high levels of uncertainty.


The 50-year-old woman developed forward toppling and tendency of fall while walking for 1 year. Slowness of motion and bilateral hand shaking when holding objects were also present concomitantly. A half year ago, she began to have bladder dysfunction and had to be catheterized for pissing in recent several months. Dizziness and occasional fainting elicited by postural change were suffered in recent 6 months. Neurological examination revealed parkinsonian features with stimulus sensitive myoclonic tremor of 4 limbs. Her gait was in short stride with a bit wide base. Orthostatic hypotension was detected with blood pressure change from 120/94 mmHg on lying to 90/68 mmHg on standing. These features suggest the diagnosis of multiple system atrophy (MSA). In addition to the salient clinical manifestations, her brain magnetic resonance imaging study revealed typical 'slit-like' marginal hyperintensity lateral from the bilateral putamina. (Fig.) Slit sign may appear in 36% of MSA patients and, occasionally, in some patients with progressive supranuclear palsy or cortical basal degeneration. Pathological and imaging correlation study showed that 'slit sign' corresponds to the areas of microgliosis, astrogliosis and the highest amounts of ferric iron deposition. Although the differential diagnosis of parkinsonian syndrome is challenging, the presence of characteristic image pattern and clinical features may, however, lead a way to secure the appropriate answer.


In 2013 the German Centre for Mathematics Teachers Education (DZLM) developed a professional development course called "stochastics compact". This course was held three times between 2013 and 2015 and reached over 270 teachers. One of its goals was to increase upper secondary teachers' competence of teaching probability and statistics in combination with the use of graphic calculators (GC). Part of the research was to examine the stages of concern (SoC) linked to the implementation. Multiple-choice questionnaires were used as a survey method. In this paper, we present two selected preliminary findings. At first we compare the SoC in the three courses 2013, 2014 and 2015 including the four cluster profiles we have identified. After that we present the changes of SoC and the migration between the clusters while participating in the course of 2015.


We are developing onboard processor (OBP) technology to streamline data acquisition on-demand and explore the potential of the L-band SAR instrument onboard the proposed DESDynI mission and UAVSAR for rapid response applications. The technology would enable the observation and use of surface change data over rapidly evolving natural hazards, both as an aid to scientific understanding and to provide timely data to agencies responsible for the management and mitigation of natural disasters. We are adapting complex science algorithms for surface water extent to detect flooding, snow/water/ice classification to assist in transportation/ shipping forecasts, and repeat-pass change detection to detect disturbances. We are near completion of the development of a custom FPGA board to meet the specific memory and processing needs of L-band SAR processor algorithms and high speed interfaces to reformat and route raw radar data to/from the FPGA processor board. We have also developed a high fidelity Matlab model of the SAR processor that is modularized and parameterized for ease to prototype various SAR processor algorithms targeted for the FPGA. We will be testing the OBP and rapid response algorithms with UAVSAR data to determine the fidelity of the products.


Male high school students reported the frequency and maximum quantity of their alcohol consumption and estimated the drinking behaviors of their same-age male peers. Consistent with past research on pluralistic ignorance and drinking that has utilized more proximal peer comparison groups, participants believed that their peers drank more frequently and in greater quantities than they themselves did. Furthermore, perception of the maximum quantity of peer drinking was a significant predictor of participants' drinking. Examination of effect sizes indicated that differences between self-reported alcohol consumption and perceived peer consumption were significantly larger for abstainers versus drinkers, which suggests that researchers should consider how the presence of abstainers in a sample may magnify majority fallacy effects. Alcohol is the drug of choice among adolescents and its use is undeniably commonplace (Gatins, 2005; National Institute on Alcohol Abuse and Alcoholism, 2006). For example, more than 50% of 8th graders, approximately 75% of 10th graders, and 81% of 12th graders have tried alcohol (Maney, Higham-Gardill, & Mahoney, 2002). Arata, Stafford, and Tims (2003) found that in their high school sample two-fifths of males frequently binged. According to the Monitoring the Future Study (Johnston, O'Malley, Bachman, & Schulenberg, 2005), 30-day prevalence figures for alcohol use during 2004 were 18.6%, 35.2%, and 48% for eighth, tenth and twelfth graders respectively; 30-day prevalence rates for having been drunk were 6.2%, 18.5%, and 32.5% among eighth, tenth, and twelfth graders respectively; and annual prevalence rates for having been drunk were 14.5%, 35.1%, and 51.8% for eighth, tenth, and twelfth graders respectively. While the highest prevalence for drinking and being drunk among high-school age adolescents is among twelfth graders (Johnston, O'Malley, Bachman, & Schulenberg, 2005), the largest jump in use occurs between eighth and tenth grade where prevalence rates of drunkenness more than double. Kindlon and Thompson (1999) assert that when adolescent males drink, they tend to abuse alcohol and drink to excess, often in response to what are perceived as challenges from peers to drink more. Because boys are often pressured to drink as a rite of passage and as proof of masculinity (Pollack, 1998), being able to "drink like a man" carries significant weight for adolescent males. According to Pollack (1998), peer pressure to drink is particularly difficult for teenage males because refusal to engage in risky behaviors is a violation of what he calls the "Boy Code." Consistent with these findings, males are generally more likely than females to be diagnosed with substance use disorders (Chambers, Taylor, & Potenza, 2003). Gatins and White (2006) have recently suggested, however, that gender differences in adolescent alcohol use may not be as salient as they once were. For example, they found that male and female high school students in their sample did not differ in the frequency of alcohol use. Although frequency of use may not differ drastically by gender, male adolescents tend to consume alcohol in greater quantities when they drink and are more likely to have drinking related problems (Arata, Stafford, & Tims, 2003; White & Huselid, 1997). Additionally, alcohol use in adolescence is more likely to be associated with aggression in young adulthood for males but not females (Duncan, Alpert, Duncan, & Hops, 1997). Male high school students, then, continue to be a uniquely vulnerable group both in terms of the quantity of alcohol they consume as well as the behaviors and consequences associated with their alcohol use. Furthermore, Aseltine (1995) suggests that mid-adolescent males, relative to females, may be more likely to conform to peer norms and values associated with alcohol use (Windle & Davies, 1999). Adolescence represents the time during which drinking behaviors are typically adopted and is also a time in which peer pressure is particularly salient (Cahalan, 1987). …


Objective To explore the expression of macrophage inflammatory protein-1β(MIP-1β) in patients with non-small cell lung cancer(NSCLC) of different pathological types and its association with clinical stages and metastasis of lymph nodes.Methods MIP-1β mRNA from fresh lung tissue of 38 NSCLC patients was amplified by RT-PCR and half-quantified.Immunohistochemical technique was performed to detect the expression of MIP-1β in paraffin-embedded lung tissue from 66 patients with NSCLC.The area and degree of positive stain were evaluated to determine the positive rate,which was compared between those with or without metastasis of lymph nodes,different pathological types and TNM clinical stages.Results MIP-1β protein was found in cytoplasm of malignant cells of squama cell cancer and adenocarcinoma without significant difference between them,while not found in bronchus-alveolus cell cancer.The MIP-1β mRNA expression in squama cell cancer and adenocarcinoma were significant higher than which in bronchus-alveolus cell cancer without significant difference between each other.The positive rates of MIP-1β in lung cancer of Ⅰ,Ⅱ and Ⅲ stages were 74.2%,29.4% and 85.7%,respectively,in which the rates inⅠand Ⅲ stages cancer were significant higher than that in Ⅱ stage.The positive rates of MIP-1β in lung cancer with or without metastasis of lymph nodes were 45.8% and 76.3%,respectively with significant difference between them.Conclusion MIP-1β is expressed in lung cancer cells and associated with the pathological type,TNM stage and the metastasis of lymph nodes.


Tiled streaming has been proposed for delivering ultra-high resolution videos such as zoomable online lectures or panoramas. In tiled streaming, the source video is first partitioned into grid of small rectangular tile groups. Each tile group is independently encoded and compressed. When an user asks for a certain viewport at a time, the server only streams the viewed tiles to save up bandwidth. However, not much work has been done on finding the best tiling method for streaming panoramic video. This paper proposes an effective tiling algorithm for tiled streaming by using both video content and user access preference distribution. Experimental results show that the proposed tiling method can save up to 32.4% and 69.8% of average streamed bitrate compared to conventional uniform tiling scheme and simply streaming the entire panorama respectively on equi-rectangular panoramic video.


This paper presents performance analysis of BPSK, QPSK and 8PSK modulations with Golay coding, Hamming coding and Convolution coding using communication system implemented in LabVIEW. Different order modulations combined with different coding schemes, allow sending more bits per symbol, thus achieving higher throughputs and better spectral efficiencies. Linear modulation techniques are bandwidth efficient and hence more useful for wireless communication system. Also this paper presents the performance analysis of block codes and convolution code both. The performance comparison is made on the basis of BER over AWGN channel.


A series of hydrogen terminated polydimethylsiloxanes (PDMS-H) had been controlled synthesized via ring-opening polymerization. Then, methylmethacrylate (MMA) and tert-butyl methacrylate (tBMA) were grafted to PDMS-H via hydrosilylation reactions in the presence of Speier's catalyst, the hydrosilylation addition patterns of MMA and tBMA showed a strong preference toward β-1,2 addition, no α-1,2 addition product or 1,4-addition product was observed. Carboxyl terminated polydimethylsiloxanes were prepared by subsequent hydrolysis reaction in an aqueous NaOH/ethanol solution and under acid condition, respectively. Both methods could obtain carboxyl terminated polydimethylsiloxanes successfully. However, a significant decrease of the molecular weight of products was observed in the alkaline hydrolysis process, while the acid hydrolysis of tertiary butyl ester group terminated polydimethylsiloxanes could be conducted in a highly controlled manner. Besides, the synthesis of carboxyl terminated polydimethylsiloxanes via acid hydrolysis reaction can be conducted well only when the terminal group of polydimethylsiloxanes is tertiary butyl, this can be explained by the specificity of tertiary butyl.


Abstract : The finite element method is applied to solids with an axis of material symmetry subjected to Fourier expandable thermal, body force and surface traction loadings. The governing equations are derived for triangular toroidal continuum elements and for thin conical shell elements. A computer program is described and various results are presented as verification. The program is described and a user's manual is given. A listing of the program source deck is included. (Author)


This paper presents a data-based approach to control robotic systems with partially-observed feedback. First, an open-loop optimization problem is solved to generate the nominal trajectory and then a linear time-varying Autoregressive–Moving-Average (ARMA) model of the system is calculated along the trajectory from the output measurement data. The system is then described in information state, which contains input-output information of the past few steps. Finally, a feedback gain which is calculated by solving a specific LQG problem along the nominal trajectory. The separate design of the open-loop and the closed-loop problem is used following the Decoupled Data-based Control (D2C) approach. Simulation results are also shown for complex models with fluid-structure interaction in the presence of both process and measurement noise.


Research on school bullying is well established and since Olweus' (1978) first significant research a multitude of studies have been published worldwide (e.g. Smith et al., 1999). Cyberbullying, which has been defined as, 'An aggressive, intentional act carried out by a group or individual, using electronic forms of contact, repeatedly and over time against a victim who cannot easily defend him or herself' (Smith, et al., 2008, p376) is a more recent phenomenon. There is a small, but growing, body of research which has examined cyberbullying, however, to date no research has looked specifically at when it emerges. The current study used focus groups with pupils (n=48), parents (n=21) and staff (n=20) from a number of primary schools to explore awareness and perceptions of the types of cyberbullying behaviours displayed in primary school and the ages at which these behaviours may first occur. The aim was to provide richer information about the nature of cyberbullying among primary school children. We will discuss our findings, specifically awareness and perceptions of the point at which cyberbullying emerges and its nature, in comparison to findings from older children and the implications for interventions and future research.


According to importance of the tool in the modern production,on the basis of tool-flow analysis, this thesis establishes reusable scheduling strategy. In this scheduling, it established a tool information management system based on the central tools magazine. The system includes the main information of each of the tools such as: number, location, usage, current state etc, and for them makes on real-time monitoring and anomalies reporting. Besides a priority mechanism is formulated for multi-tool and multi-task in the scheduling. Finally, the reusable scheduling has been modeling and simulation. To run the emulation program proved that the real-time and effectiveness of the tool management system, and the result of running is analyzed under configurations include the number of different tool, which for the actual production scheduling of tool provides the algorithms and software platforms.


The species of the subgenus Inaequalium are reviewed based on adult and pupal morphology. All main taxonomic characters are fully illustrated together with a key to pupae for species identification. Discussions on the species' taxonomy and brief summaries of their distribution and biology are also provided. As a result of this study, 14 species are now included in the subgenus Inaequalium. They are placed into two species groups, the botulibranchium species group with three species and the inaequale species group with 11 species, including two that are treated as species inquirendae: S. lurybayae Smart and S. parimaense Ramirez-Perez, Yarzabal, Takaoka, Tada & Ramirez. Simulium lurybayae Smart, S. margaritatum Pepinelli, Hamada & Luz and S. maranguapense (Pessoa, Rios-Velasquez & Py-Daniel) are now placed in the inaequale species group. Two lectotypes are designated for the following species: S. clavibranchium Lutz and S. diversibranchium Lutz. Simulium hauseri (Coscaron & Coscaron-Arias) is regarded as an unavailable name.


The sphere of national security is the area where various authorities operate. The widest range of competences is granted to the executive, but the legislator (and also the judiciary) is not deprived of influence within this field. The Sejm has special powers within the legislative power. As far as its constitutional competence referring to the national security is concerned, the Sejm essentially takes action not when dealing with the normal functioning of the state, but in the case of specified threats. Even ending a state of war is a consequence of prior specified threats. The constitutional competence of the Sejm in this field basically covers states of emergency and state of war, the latter not being included in this category by the legislator. The Sejm holds here legal tools that allow it to finally decide on the validity of these situations (except for the state of natural disaster, where the Sejm agrees on its extension).


Soil, sand and gravel are the conventional substrates used in constructed wetland presently, but the disadvantages of these substrates are lower purified efficiency, easily saturation and low removal rates for N and P from domestic wastewater.In allusion to these, the simulating system in this experiment was designed and the substrates poles system using zeolite, peat composed of rotten mosses, vermiculite, shale and sand as substrates simulating actually vertical CW was constructed to treat domestic wastewater for studying the relationship between the variety and the depth of different substrates and the removal rate of TN, TP.The variance of five kinds of substrates and six depths was analysis used SPSS indicated that(1)the ability for removing TN of different substrates was similar, only zeolite, vermiculite and shale were better in some sort.And the order of excellence for removing TP is peat composed of rotten mosses, shale, sand, zeolite, vermiculite.(2)The depth of substrates had little effect on the removal of TN.Within 100 cm, the removal rates of TP of these five substrates became higher with the increasing depth, while exceeding 80 cm, this trend was not obvious.So, for these two indexes, the optimal depth of substrates is 100 cm.


Dynamic pressure type foil bearings are expected to serve as shaft bearings for Micro Gas Turbines (MGT). In this study, in order to establish design guidelines of radial foil bearings, dynamical modeling of multi wounded foil bearing was carried out employing leakage flow induced vibration theory. Taking frictional forces due to attached part of the foil and the protrusion, etc. into consideration, static and dynamic characteristics were analyzed to examine the performance and the stability of radial foil bearings.Copyright © 2006 by ASME


In recent years, semi-active vibration control using synchronized switching damping on negative capacitance (SSDNC) has been presented. However, the standard SSDNC relies heavily on the external sensors and equipment to control the switches. This paper presents a self-sensing semi-active vibration control method using SSDNC for piezoelectric vibration suppression. The advantage of the new method is no external sensors are required. The piezoelement is used not only as actuator but also sensor. The effectiveness of this method is demonstrated by comparing with self-sensing SSDI (synchronized switching damping on Inductor). Theoretical computation and experimental results show a remarkable effectiveness for vibration suppression.


Radiation‐induced lung injury (RILI) frequently occurs in patients with thoracic malignancies. In response to radiation, alveolar epithelial cells (AEC) undergo epithelial‐mesenchymal transition (EMT) and contribute to the pathogenesis of RILI. Insulin‐like growth factor binding protein 7 (IGFBP7) is reported as a downstream mediator of transforming growth factor‐β1 (TGF‐β1) pathway, which plays a crucial role in radiation‐induced EMT. In the present study, the levels of IGFBP7 and TGF‐β1 were simultaneously increased in experimental RILI models and radiation‐treated AEC (human pulmonary alveolar epithelial cells [HPAEpic]). The expression of IGFBP7 in radiation‐treated HPAEpic cells was obviously inhibited by the specific inhibitor of TGF‐β receptor antagonist SB431542 and TGF‐β1 neutralizing antibody, and time‐dependently enhanced by TGF‐β1 treatment. Moreover, IGFBP7 knockdown significantly attenuated the effects of radiation on morphology change, cell migration, expression of EMT‐related markers (E‐cadherin, α‐SMA, and Vimentin), and phosphorylation of extracellular‐signal‐regulated kinase (ERK). The effects of IGFBP7 overexpression on the expression of EMT‐related markers were partially reversed by the ERK inhibitor PD98059. In conclusion, IGFBP7, was enhanced by TGF‐β1, may be involved in radiation‐induced EMT of AEC via the ERK signaling pathway, thus contributing to the pathogenesis of RILI.


The quantitative risk assessment and consequence analysis by accident scenario in the process of EPS(Expendable Poly Stylene) reaction process are conducted. And the decision making process is studied followed by selecting various alternatives to safety management and facility improvement. The result are as follows; 1) The object of decision making through comprehensive risk assessment are the scenario which can cause four major accident, which are made by process analysis, work analysis and hazard identification. 2) Frequency analysis of ETA, FTA, HRA and consequence analysis of accident to each have been conducted. The each frequency values are yielded 9.2×10^(-5)/yr to scenarios 1, 8.2×10^(-4)/yr to scenario 2, 4.5×10^(-6)/yr scenario 3 and 1.8×10^(-7)/yr to scenario 4. The each scenarios have been conducted consequence analysis. 3) The calculated values have been obtained 4.00 to scenario 1, 3.25 to scenario 2, 2.43 to scenario 3 and 1.34 to scenario 4, as the weight value had been applied to the quantitative and normalized criteria of all components. As a risk criteria, scenario 1 have been selected, which is the most dangerous scenario as a result of ranking the scenario. 4) According to the importance of FTA and contribute to scenario 1, the cost-benefit values are yielded 8.05×10^5[₩/yr] to final alternative(A1), 1.55×10^5[₩/yr] to final alternative(A2) and 2.32×10^5[₩/yr] to final alternative(A3). As a result of final alternative(A1) has been selected, which is the most optimized alternative.


This study is intended to find out and analyze not only grammatical errors but also errors in arranging formats of business letters. This study is conducted by using descriptive qualitative approach and the data are from JPAC of Polban holding a Job Fair in 2012. The data of this study are the55 non-English Department students of Politeknik Negeri Bandung joining this Job Fair. The grammatical errors are classified based on the surface strategy taxonomy proposed by Dulay et al (1982), they are omission (71 errors), addition (35 errors), mis-formation (52 errors), and mis-ordering errors, while errors in formats of business letters are based on Taylor (2004), Geffner (1995), and Ashley (1984). The grammatical errors are first classified into five major categories and then they are divided by sub-categories. After observing, it is found that the largest number of errors is preposition. The following most problematic areas respectively are verb, after that article, followed by plural, and the least is tense. Inter-lingual and intra-lingual transfers are considered as the major cause of these errors. Furthermore, the errors in arranging layouts of business letters based on UK concept are classified into 6 categories, and the highest number of errors is found in sender address, followed by enclosure, after that complimentary close, then salutation, date, and the last is style. The cause of the errors is the students are probably lack of the knowledge of English business letter concept. Based on research findings, some suggestions are given to the teachers and the students. The teachers should pay more attention to writing to make the students succeed in providing Standard English sentences and they should give more practicing in writing letters. The students should use most of their spare time in reading English books or newspapers or magazines and they don't be lazy to practice more how to write well- organized letter.


Port systems are more prone to being risk oriented. Many specific methods have been found to assess risk in a port area or operation. A review is presented in different approaches on human and environmental risks in port area. On the other hand, there is no specific risk management method or framework to cope with threats and hazards regarding on port machines or material accidents and port assets damages or losses. This paper presents a risk management methodology, seeking to investigate a process of assessing the assets hazards and damages into the domain of port container terminal, by taking into account its different factors and their mutual influences. This methodology constitutes a decision support framework that will be used to conduct port to port risk evaluations or to assess a whole port's and terminal's risk level in the critical field of assets damages and losses, in order to facilitate improvement strategies. An empirical study is contacted for the years of 2003~2012, in order to provide evidence for risk assessment and management in an economic effective way, regarding port assets damages and losses, at the Port Container Terminal of Piraeus in Greece.


AIM
The purpose of this prospective study was to evaluate single-frequency whole-body bioelectrical impedance analysis (BIA) as a predictor for the onset of edema of the upper limb in patients undergoing treatment for breast cancer.

MATERIALS AND METHODS
Whole-body BIA was performed before surgery, as well as at two days, and one, three, six and twelve months after surgery.

RESULTS
Sixty women undergoing breast cancer surgery were examined, with loss of follow-up of 18 patients. Seven patients (14.3%) developed an edema of the upper limb within the first 12 months after surgery. Resistance (R) using whole-body BIA showed a fairly good performance in terms of sensitivity (85.71%) and specificity (97.4%) at predicting edema. The positive predictive value of 54.6% was unsatisfactory, whereas the negative predictive value was 97.4%.

CONCLUSION
Resistance in whole-body BIA can be used to rule-out a developing edema of the upper limb.


The concentration of hydrogen ion is normally managed by several buffering and elimination systems, including the kidney. Consequently, progressive renal failure is accompanied by an increasing inability to excrete metabolites of fuel consumption, lower blood pH, and reduced plasma bicarbonate levels,1,2 but is the inverse true? Can correcting this chronic metabolic acidosis slow or prevent progressive kidney damage?

An elegant series of experiments several years ago by Mitch and colleagues3–6 found that metabolic acidosis in the rat activates the ubiquitin-proteasome pathway, leading to increased protein breakdown to amino acids, including glutamate, which is excreted by the proximal tubule as ammonium. Nath et al. 7 observed even earlier that nitrogen nucleophiles such as ammonia are injurious to the kidney and stimulate chronic tubulointerstitial inflammation through a complement-mediated pathway. Both findings together suggest a deleterious multisystem mechanism contributing to progression of chronic kidney disease (CKD).

Data from studies of rats on the effects of alkali therapy in CKD …


Three beakers for removing Fe (II) in reconstituted water (doped with FeSO 4 ) were built and tested. Given the set operating conditions ([O 2 ] > 4 mg·L −1 , P atm = 1.013 bar, T = 25˚C ± 1˚C and [Fe 2+ ] 0 = 0.5 to 2 mg·L −1 ), removal of iron was caused by biological and possibly physical and chemical oxidation because there is a quantity of free oxygen in the medium. The extent of each type of oxidation has not been evaluated as it specifically studies the biological degradation of iron in these beaker tests by setting the operating conditions (pH > 6.5, dissolved oxygen from 0 to 8 mg·L −1 , Redox Potential from 100 to 400 mV). The experimental studies focused particularly on the measurements of maximum wavelength, conversion efficiencies from Fe (II) to Fe (III), the effect of the Fe (II) concentration, the influence of pH, the action of the temperature of the prepared solutions and the effect of O 2 concentration under specified operating conditions. It noticed precipitated amounts of iron deposited at the bottom of the beakers. Thus, the low concentrations of Fe (II) detected in the influent after the biological oxidation operation could be attributed to microorganisms that consume iron as a substrate.


In an investigation of the international crisis preceding the outbreak of World War I, Holsti and North found that the foreign policy decision-makers of the nations involved tended to view "themselves as the victims of injury, but regarded their political enemies as primarily the targets of friendship and agents of hostility. More significantly, in lno case did even a nation's allies share to the full degree that nation's sense of injury."2 Further, they suggest that this pattern of perception may not be unique to the 1914 crisis.


Community nurses have welcomed the recent change to the licensing laws allowing children in pubs, but have called on the government to issue clearer guidelines to licensing magistrates, as they prepare to issue the first children's bar certificates.


Background
 TAK-659 is an investigational, oral, reversible, and potent dual inhibitor of spleen tyrosine kinase (SYK) and FMS-like tyrosine kinase 3 (FLT3). TAK-659 has demonstrated inhibitory activity in preclinical models of diffuse large B-cell lymphoma (DLBCL) and single-agent clinical activity in patients with relapsed or refractory (R/R) DLBCL in a phase 1 study. We conducted an open-label, multicenter, phase 2 study to evaluate the efficacy and safety of TAK-659 as a single agent in patients with R/R DLBCL after ≥2 prior lines of chemotherapy (NCT03123393), which represents an unmet medical need for which there was no standard of care available at the time the study opened.
 Methods
 Eligible patients were aged ≥18 years, had histologically confirmed DLBCL, including de novo disease or transformed disease from indolent NHL, R/R disease after ≥2 but no more than 4 prior lines of chemotherapy. Patients must have either relapsed after or not been eligible for autologous stem cell transplant. This phase 2 study included a lead-in dose-exploration phase (Stage 1) in which patients received TAK-659 100 mg QD (Cohort A) or TAK-659 in a 3-dose-level ramp-up schema from 60 mg to 80 mg to 100 mg QD per cycle (Cohort B) in 28-day treatment cycles until disease progression, unacceptable toxicity, or withdrawal for other reasons. The objectives of Stage 1 were to assess the safety and tolerability of TAK-659 and to select one TAK-659 dose regimen to proceed to Stage 2 based on overall response rate (ORR) per investigator assessment. If both Stage 1 dose regimens were determined to be ineffective, the study would be terminated without proceeding to Stage 2. This abstract presents data from Stage 1. Safety was assessed using the NCI CTCAE, version 4.03. Efficacy was assessed by investigators using a modified 2007 IWG criteria for malignant lymphoma.
 Results
 At data cutoff (April 25, 2019), 49 patients had been enrolled and had received TAK-659 100 mg QD (n=24) or TAK-659 ramp-up dosing (n=25). The median age of patients was 65 years (range, 30-81 years) and 29 (59%) were male. Disease subtypes were DLBCL not otherwise specified (n=45), T-cell/histiocyte-rich large B-cell lymphoma (n=1), grade 3b follicular lymphoma (n=2), and other (n=1). 61% of patients were Ann Arbor stage IV. Patients had received 2 (49%), 3 (45%), or 4 (6%) prior lines of therapy. At data cutoff, 44 patients (90%) had discontinued treatment, most frequently due to progressive disease (61%) or adverse events (AEs; 14%). Patients administered TAK-659 100 mg QD in Cohort A received a median of 1.5 treatment cycles (range 1-14), and those administered ramp-up dosing in Cohort B received a median of 1 treatment cycle (range 1-9). All patients experienced ≥1 treatment-emergent AE (TEAE); the most frequent (≥30%) were pyrexia (42%), increased aspartate aminotransferase, and cough (both 38%) in Cohort A, and pyrexia (44%) and fatigue (32%) in Cohort B. Treatment-related TEAEs were experienced by 88% of patients in Cohort A and 60% of patients in Cohort B. Grade ≥3 TEAEs were reported in 92% of patients in Cohort A and 72% in Cohort B. In Cohort A, the most common grade ≥3 TEAEs (≥15%) were anemia (21%), increased blood creatinine phosphokinase, and hypophosphatemia (both 17%). In Cohort B, the most frequently reported grade ≥3 TEAEs (≥5%) were progression of lymphoma (12%), anemia, neutropenia, and increased amylase and lipase (all 8%). Overall, 33% of patients discontinued due to TEAEs, which were considered treatment-related in 18% of patients. The difference between the rate of discontinuation due to TEAEs in each cohort was negligible. Three on-study deaths due to a TEAE occurred in each cohort, all of which were deemed related to the disease under study or complications thereof. Dose reductions occurred in 5 patients in Cohort A and none in Cohort B. Two patients achieved a complete response (1 in each cohort) and 6 achieved a partial response (3 in each cohort), giving an ORR of 16% (Table). Median duration of response was 8.3 (range 0-13) months. Five patients remain on study drug; 4 in Cohort A, 1 in Cohort B. Stage 2 of this study was not initiated due to lack of efficacy in Stage 1.
 Conclusions
 The TAK-659 100 mg QD and ramp-up dosing schedules were generally well tolerated in patients with R/R DLBCL, and there were no new safety signals. Based on the limited efficacy of TAK-659 in this heavily pretreated patient population, the study did not proceed to Stage 2, and enrollment was closed.

 Phillips: Seattle Genetics: Consultancy; Gilead: Consultancy; Incyte: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees; Bayer: Consultancy; Abbvie: Research Funding; Pharmacyclics: Consultancy, Research Funding; Genentech: Consultancy. Salles:Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Educational events; Epizyme: Consultancy, Honoraria; Merck: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Novartis, Servier, AbbVie, Karyopharm, Kite, MorphoSys: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Educational events; Autolus: Consultancy, Membership on an entity's Board of Directors or advisory committees; Amgen: Honoraria, Other: Educational events; BMS: Honoraria; Roche, Janssen, Gilead, Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Educational events. Landsburg:Curis, INC: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Seattle Genetics: Speakers Bureau; Seattle Genetics: Speakers Bureau; Takeda: Research Funding; Takeda: Research Funding; Triphase: Research Funding; Celgene: Membership on an entity's Board of Directors or advisory committees; Curis, INC: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Membership on an entity's Board of Directors or advisory committees; Triphase: Research Funding. Gritti:Autolus Ltd: Honoraria; Roche: Other: Not stated; Abbvie: Other: Not stated; Becton Dickinson: Other: Not stated. Patel:Genentech: Consultancy, Speakers Bureau; Celgene: Consultancy, Speakers Bureau; AstraZeneca: Consultancy, Research Funding, Speakers Bureau; Sunesis: Consultancy; Pharmacyclics/Janssen: Consultancy, Speakers Bureau. Tilly:Roche: Consultancy; Celgene: Consultancy, Research Funding; Astra-Zeneca: Consultancy; Karyopharm: Consultancy; BMS: Honoraria; Janssen: Honoraria; Gilead: Honoraria; merck: Honoraria; servier: Honoraria; roche: Membership on an entity's Board of Directors or advisory committees. Thieblemont:Roche: Honoraria, Research Funding; Gilead: Honoraria; Novartis: Honoraria; Kyte: Honoraria; Janssen: Honoraria; Celgene: Honoraria; Cellectis: Membership on an entity's Board of Directors or advisory committees. Townsend:Roche: Consultancy, Honoraria. Stumpo:Millennium Pharmaceuticals, Inc., Cambridge, MA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited: Employment; Astra Zeneca: Equity Ownership; Teva Pharmaceuticals: Equity Ownership. Katyayan:Millennium Pharmaceuticals, Inc., Cambridge, MA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited: Employment; Cytel Inc.: Employment. Li:Millennium Pharmaceuticals, Inc., Cambridge, MA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited: Employment; Pfizer: Employment. Miao:Millennium Pharmaceuticals, Inc., Cambridge, MA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited: Employment, Equity Ownership. Proscurshim:Millennium Pharmaceuticals, Inc., Cambridge, MA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited: Employment. Gopal:Seattle Genetics, Pfizer, Janssen, Gilead, Sanofi, Spectrum, Amgen, Aptevo, BRIM bio, Acerta, I-Mab-pharma, Takeda, Compliment, Asana Bio, and Incyte: Honoraria; Seattle Genetics, Pfizer, Janssen, Gilead, Sanofi, Spectrum, Amgen, Aptevo, BRIM bio, Acerta, I-Mab-pharma, Takeda, Compliment, Asana Bio, and Incyte.: Consultancy; Teva, Bristol-Myers Squibb, Merck, Takeda, Seattle Genetics, Pfizer, Janssen, Takeda, and Effector: Research Funding.

 TAK-659 is an investigational, oral, reversible, and potent dual inhibitor of spleen tyrosine kinase (SYK) and FMS-like tyrosine kinase 3 (FLT3)


Abstract The partitions of a positive integer n in which the parts are in arithmetic progression possess interesting combinatorial properties that distinguish them from other classes of partitions. We exhibit the properties by analyzing partitions with respect to a fixed length of the arithmetic progressions. We also address an open question concerning the number of integers k for which there is a k-partition of n with parts in arithmetic progression.


The time evolution operator is obtained by using the gauge transform of algebra dynamics and the expectation of coherent state for the external driven oscillator system.It is shown that the results of two methods are the same.


We report the occurrence of rhabdoid cells in several specified soft tissue sarcomas of round cell variety. The rhabdoid cells had an acidophilic cytoplasm containing a globular perinuclear inclusion and were characterised ultrastructurally by the presence of aggregates of 10 nm intermediate filaments. These filaments contained both cytokeratin and vimentin, as demonstrated immunohistochemically. Extensive sampling of soft tissue sarcomas revealed the presence of such cells in different types of soft tissue round cell sarcomas as follows: 12 of 13 cases of epithelioid sarcomas, 8 of 13 synovial sarcomas (composed predominantly of round cells), 6 of 20 extraskeletal myxoid chondrosarcomas and 4 of 4 round celled malignant mesotheliomas. We wish to stress that the appearance of rhabdoid cells is not a monopoly of one particular type of tumour.


Exact and truncated homogeneous difference schemes of arbitrary order of accuracy are constructed and investigated for the one-dimensional second-order equation , , with generalized solutions in . Mathematical tools are developed for studying the accuracy of truncated difference schemes. It is assumed that is a measurable function, while and are generalized derivatives of functions in the class , , ; this allows one to include the case in which and are -functions. It is shown that truncated schemes of th order have accuracy , where is the mesh step size and a number depending on the exponents , , , and . In the case of piecewise smooth coefficients , and the estimates obtained coincide with results of the theory of homogeneous difference schemes of Tikhonov and Samarskiĭ.Bibliography: 13 titles.


Dear Editor,

Regarding the article: Application of queuing theory to decrease waiting times in emergency department: Does it make sense? published in Archives of Trauma Research (1), I would like to make some comments. Although results of the study by Alavi-Moghaddam et al. using queuing theory are particularly interesting to analyze the impact of a new strategy to reduce waiting times before implementing it, all the proposals offered an increase of resources or staff: adding one or more senior emergency residents on each shift, adding one more bed to intensive care unit, adding another clerk to take electrocardiograms in ED, and expanding the laboratory staff and specialist consultants by 50%. It has been argued that adding resources is not simply sufficient to fix the flow problems in ED (2). Although there are a variety of medical, social, financial and other external causes for crowding, the internal organization of ED is often a source of inefficiencies. Dr. Ng et al. in an ED from Ontario (3), attempted various solutions to improve waiting times. They increased the number of triage nurses and stations, added medical directives, increased physician staffing, hired a nurse practitioner and opened a fast track area. Despite increasing resources and staffing, there was little appreciable impact on overall waiting times; therefore they tried another way to improve ED efficiency. They applied philosophies and tools from the Toyota Production System (Lean thinking) to improve productivity and reduce waiting times. By eliminating waste from their internal ED processes, improving workplace organization, focusing on reducing interruptions and internal waits, and continuously refining improvements, waiting times, length of stay, and patient satisfaction improved with no additional staff or beds. The goal of Lean is to refine production in such a way that work flows smoothly from one step to the next with no wasted time, effort, or resources. The essential elements of each step are identified. Any step that does not add value to the product is considered waste or muda. The process is then reorganized to eliminate any muda. The new process is then standardized, mistake-proofed, and implemented, a process of continual, incremental improvement called Kaizen in Japanese. R. Holden critically reviewed 18 articles describing the implementation of Lean in 15 ED in the United States, Australia and Canada (4). The review revealed numerous ED process changes, often involving separate patient streams, structural changes such as new technologies, communication systems, staffing changes, and the reorganization of physical space. Patient care usually improved after implementation of Lean, with decreases in the length of stay, waiting times, and proportion of patients leaving the ED without being noticed. Success factors included employee involvement, management support, and preparedness for change. However, Lean is not a panacea, but rather a tool that may or may not succeed, according to the efforts surrounding its use. Dickinson et al. showed the first case series with negative results in a hospital that had attempted to implement Lean (5). What was common across the successful EDs was the strict adherence to Lean principles.


Thesis (M.A.)--American University of Beirut, Dept. of Education, 2008.;"Advisor : Dr. Amy Zenger, Assistant Professor , Department of English--Member of Committee : Dr. Ghazi Ghaith, Professor , Department of Education--Member of Committee : Dr. Roseanne


In this paper, an embedded zerotree wavelet transform (EZWT)-based technique is employed for the data denoising and compression in the smart grid (SG). The EZWT is a simple but effective data compression algorithm. This technique does not need any training, prestored tables or codebooks, and prior knowledge of the data source. In this paper, the analysis and subsequent compression and denoising properties of the EZWT are examined for power system signals in SG. The proposed approach is evaluated using phasor measurement units and power system data. Experimental results demonstrate that the presented method both compresses the signal and depresses the noise contained in the signal. Comparative compression and noise removal results are presented with the wavelet transform.


Though angioma is usually a benign tumor, it sometimes degenerates into a malignant growth, and surgical intervention is necessary. In about 65 per cent of the cases angioma is located on the face and therefore is mutilating. The second peculiarity of angioma is that it occurs in childhood in 80 per cent of the cases. Both these circumstances limit the method of treatment. Naturally, angioma of the face has not only an indirect but a direct relation to the organ of sight. The statistical data of Maas (cited by Michel1) showed that the face in general was involved in 104 instances (81.5 per cent) and the eyelids in particular in 12 instances. Holdin2stated (data from the Oncologic Institute, Leningrad) that angioma of the face occurred in 175 of 261 cases (67 per cent), in 16 per cent (28 cases) of which the eyelids were affected. Beljaev


The greatest losses in brown hare population appear during the reproduction period in winter season. Since it is not possible to give a precise assessment of adult hare loss, this paper proposes its expression in coefficients. Losses during reproduction period are calculated as correlation of autumn headcount, bagged game, actual growth coefficient and spring headcount. According to results of our investigations, average losses in reproduction period range between 11.93% and 47.01%, or on the average annually 32%. Winter losses are calculated by utilising the same parameters with the difference of spring headcount which has been included in this study in the following year. In order to determine more adequate and precise state of losses accurately, it is necessary to identify losses due to game wounding. Average losses between start of hunting season (October) and beginning of following reproduction period (March) range between 3.25% and 45.47%, or on the average annually 32% during 41-year period in the hunting grounds of Vojvodina. As losses are considerably bigger than in previous period (when they were approx. 20-25%), authors propose the acceptance of new losses value (32%) in creation of planning documents.


The effects of projectile canting and fins on the ram accelerator combusting flowfield and the possible cause of the ram accelerator unstart are investigated by performing axisymmetric, two-dimensional, and three-dimensional calculations. Calculations are performed using the INCA code for solving Navier-Stokes equations and a guasi-global combustion model of Westbrook and Dryer (1981, 1984), which includes N2 and nine reacting species (CH4, CO, CO2, H2, H, O2, O, OH, and H2O), which are allowed to undergo a 12-step reaction. It is found that, without canting, interactions between the fins, boundary layers, and combustion fronts are insufficient to unstart the projectile at superdetonative velocities. With canting, the projectile will unstart at flow conditions where it appears to accelerate without canting. Unstart occurs at some critical canting angle. It is also found that three-dimensionality plays an important role in the overall combustion process.


Acknowledgments Introduction 1 Susanna Pasolini and the Female Universe 2 Mothers 3 Prostitutes 4 Daughters 5 Saints 6 Sinners 7 Salo and Petrolio Appendix: Filmography of Pier Paolo Pasolini Notes Bibliography Index


Objective: The current study aimed at the investigation of the effectiveness of ethanolic and methanolic extract of Polygonum glabrum in aluminum chloride-induced Alzheimer's disease in experimental rats.
Methods: The behavioral parameters evaluated by following methods such as Morris water maze test, radial arm maze test, and active avoidance test. Biochemical parameters were also estimated such as acetylcholine and acetylcholine esterase.
Results: Polygonum glabrum extract was instituted to be neuroprotective against AlCl3-induced toxicity. Enhanced learning and memory were allied to the ingestion of extract in rats. Al overload, acetylcholinesterase enzyme hyperactivity is responsible for Alzheimer's disease which is neutralized or reduced with treatment of extract, which might be due to the synergistic action of its active constituents. Ethanolic extract was shown slightly higher efficacy as compared to methanolic extract.
Conclusion: Based on these current findings, it is suggested that lowering Aβ is an unproven strategy, and it may be time to refocus on other targets for the treatment of this disease, including pathological forms of tau.


The present study explained the adsorption potential of sweet lime peel to remove selenium from aqueous solution. The presence of -OH, -N-H, C=0,-C-0 groups play major role in adsorption of selenium ions onto adsorbent. The surface morphology pretends to be porous in nature. The optimum equilibrium time and pH was 120 min and 4.0.The adsorption isotherm fitted best was D-R. The monolayer adsorption capacity of sweet lime peel was 1.213. The adsorption data was best fitted by pseudo- second order kinetics with regression coefficient of 0.997 and liquid film diffusion model was rate controlling step. The positive value of ∆H and ∆S suggest that the process was endothermic and randomness at solid - solution interface.


An electronic tunable composite right/left-handed (CRLH) transmission line (TL) leaky-wave antenna (LWA) with horizontal scanning properties based on liquid crystal is presented. The advantages of the proposed antenna are: 1) Convenient to fabricate; 2) Scanning range from negative angle to positive angle; 3) Scanning in a horizontal plane; 4) Convenient to constitute an array. The transmission and radiation characteristics of the CRLH LWA are theoretically analyzed and simulated.


Within the context of DLs, we are making information objects Òfirst-class citizensÓ. We decouple information objects from the systems used for their storage and retrieval, allowing the technology for both DLs and information content to progress independently. We feel that dismantling the current stovepipe of ÒDL-archive-contentÓ is the first step in both building richer DL experiences for users and insuring the long-term availability and integrity of digital information. To demonstrate this partitioning between DLs, archives and information content, we introduce ÒbucketsÓ, aggregative, intelligent, object-oriented constructs for publishing in digital libraries. Buckets exist within the Smart Objects, Dumb Archives (SODA) DL model, which dictates that functionalities and responsibilities traditionally associated with archives are pushed down into the buckets, making the buckets ÒsmarterÓ and the archives ÒdumberÓ.


This study employs factor analysis to develop a conceptual model of bank financial condition from financial ratios and other characteristics in Nigerian banking. It paints the anatomy of the phenomenon in a conceptual model around the prudential application of market power and market presence to transform deposit mobilisation, under a given macro-economic condition, into earnings quality with capital boosting confidence. The finding is relevant in the understanding of the 2008 global financial crisis. In the context of the global macro economy, the framework casts the current global financial meltdown in the light of the failure of market power and market presence to transform deposit mobilisation into earnings quality as imprudence stretched the sub-prime mortgage and credit default swap risks. Since capital could not offer cushion, confidence fell and bank financial condition grew worse.


This article manifests the socio-political and cultural background of the emergence of satellite television in Bangladesh. Although the Bangladesh Government highlights the religio-teritorial identity of the people of Bangladesh, it adopts the enigmatic geo-political strategy in challenging the penetration of Indian culture through satellite television in the country. Although the government is very loud in designing its own Bangladeshi culture by denying the past link with West Bengal and disowning a huge chunk of cultural heritage, its role remains paradoxical in resisting the cultural hegemony of India through the penetration of satellite television in Bangladesh.


A polarizing plate, a method of preparing the same and a liquid crystal display apparatus including the same are disclosed. The polarizing plate includes a polarizer and a polyester film formed on a surface of the polarizer, wherein the polyester film has a ratio of an elongation ratio in a machine direction to an elongation ratio in a transverse direction of about 1:0.8 to about 1:1.2, an in-plane retardation (Re) of about 500 nm or less at a wavelength of 550 nm, and an out-of-plane retardation (Rth) of about 10,000 nm or less at a wavelength of 550 nm.


In this paper,it puts forward the problem on the information reliability in making oil supply standard,figures out the signal hint model and analyzes the model,reachs the conclusion,provides the theories foundation for reasonable making.


Semi supervised learning is a relatively new area in machine learning which represents the blend of supervised and unsupervised learning. It has the potential of reducing the need of expensive labeled data whenever only a small set of labeled examples are available. In this paper semi supervised learning algorithm combining Logical data analysis based on complete binary tree with Naive Bayes and SVM with learning based on both labeled and unlabeled data is proposed for detecting breast cancer. Few labeled data are used as supportive set to build the diagnostic model which is used for classifying the unlabeled data. Wisconsin breast cancer dataset from the UCI machine learning depository is used for the experiment. This algorithm yielded an accuracy of 98.7% for unlabeled samples.


The influence of high concentrations of zolpidem (100 μM, corresponding to approximately 200 times maximum therapeutic concentrations) on the activity of six human Cytochrome P450 (CYP) enzymes was evaluated in a model system using human liver microsomes. Zolpidem produced negligible or weak inhibition of human CYP1A2, 2B6, 2C9, 2C19, 2D6, and 3A. Transport of rhodamine 123, presumed to be mediated mainly by the energy‐dependent efflux transport protein P‐glycoprotein, was studied in a cell culture system using a human intestinal cell line. High concentrations of zolpidem (100 μM), exceeding the usual therapeutic range by more than 100‐fold, produced only modest impairment of rhodamine 123 transport. The findings indicate that zolpidem is very unlikely to cause clinical drug interactions attributable to impairment of CYP activity or P‐gp mediated transport. Copyright © 2002 John Wiley & Sons, Ltd.


In this paper we study estimating Generalized Linear Models (GLMs) in the case where the agents (individuals) are strategic or self-interested and they concern about their privacy when reporting data. Compared with the classical setting, here we aim to design mechanisms that can both incentivize most agents to truthfully report their data and preserve the privacy of individuals' reports, while their outputs should also close to the underlying parameter. In the first part of the paper, we consider the case where the covariates are sub-Gaussian and the responses are heavy-tailed where they only have the finite fourth moments. First, motivated by the stationary condition of the maximizer of the likelihood function, we derive a novel private and closed form estimator. Based on the estimator, we propose a mechanism which has the following properties via some appropriate design of the computation and payment scheme for several canonical models such as linear regression, logistic regression and Poisson regression: (1) the mechanism is $o(1)$-jointly differentially private (with probability at least $1-o(1)$); (2) it is an $o(\frac{1}{n})$-approximate Bayes Nash equilibrium for a $(1-o(1))$-fraction of agents to truthfully report their data, where $n$ is the number of agents; (3) the output could achieve an error of $o(1)$ to the underlying parameter; (4) it is individually rational for a $(1-o(1))$ fraction of agents in the mechanism ; (5) the payment budget required from the analyst to run the mechanism is $o(1)$. In the second part, we consider the linear regression model under more general setting where both covariates and responses are heavy-tailed and only have finite fourth moments. By using an $\ell_4$-norm shrinkage operator, we propose a private estimator and payment scheme which have similar properties as in the sub-Gaussian case.


The article is a first attempt to tackle Borys Grinchenko's theoretical paper "The Management of Inspiration" (1893) in the Ukrainian literary studies. The manuscript of Grinchenko's paper is kept at the Institute of Manuscripts of the National Library of Ukraine named after V. I. Vernadsky. The subject of the research is the writer's views on the psychology of creativity. The article aims to consider the theoretical views of the Ukrainian philosopher on the problem of inspiration as a special creative venue of the artists, writers or composers, the management of which can affect their productivity.

The results of the study enable to detect the influence of both idealistic and positivist-oriented aesthetics in Grinchenko's theoretical approach to the cultivated creativity. The Ukrainian philosopher is resolute in denying the idea of inspiration as a rapidly passing special state which cannot be managed for example by the writer. Nor does he accept the possibility of productive creativity only in the moments of emotional outburst or transcendence.

Grinchenko develops coherently the idea that the ingenious writers systematically experienced inspiration relying on the skill, worked out over the years, to create at a fixed time. In his opinion, the timing for different types of activity allowed those writers to evoke special spirituality at certain hours, when aesthetic performance is the most productive. In his paper, B. Grinchenko insists on the need for each creator to handle the inspiration by means of the skillful management of creative process.
The ideas of the Ukrainian philosopher on the possibility of managing writer's insight keep with the Hegelian thesis of creative inspiration as a natural result of the artist's hard work. B. Grinchenko regards inspiration as an animating force that can be set in motion by daily routine. Every writer's moment of the highest revelation proceeds differently; its every stage can be differently time-bound. Yet Borys Grinchenko hopes that in the future the development of literary processes will lead most writers to a disciplined and manageable way of creativity.

The ideas of Grinchenko's paper on the bonding of inspiration and the titanic work of the writer are up-to-date.


In general, intellectual property rights relate to a collection of intangible assets held and legally protected by an individual or corporation from outside use or implementation without approved approval, such as invention, creativity, and contributions to the relevant area of expertise. The economic process, financial incentive, and motivation for advanced innovations engrained in the appropriate legal protection of Intellectual Property Rights demand expert, guided, and constantly updated assistance in the field of Intellectual Property Rights. With the tremendous rate of technical, scientific, and medical innovation that we are experiencing today, intellectual property has become increasingly crucial. Furthermore, developments in the global economic climate have had an impact on the creation of business models in which intellectual property is a key component in building value and prospective growth. Several new intellectual property legislations have been passed in India in order to fulfil international commitments under the WTO Agreement on Trade-Related Aspects of Intellectual Property Rights. As a result, intellectual property has become one of the world's largest and fastest-growing disciplines of law, necessitating the need for specialists to deal with IP. Copyright is a broad sphere that encompasses innovations, creations, intellectual products in print, audio-visual, sign & symbol, and digital formats. Copyright is a tremendous stimulant for the social media industry, which is full of invention and innovation. Media platforms, including social media, employ creative ideas, pictures, sounds, scripts, and a variety of other tools and ways of communication for professional, commercial, and individual aspirations. All of these forms, which are generated by individuals and businesses with rigorous efforts in design, research, and development, need a significant expenditure. These projects were built through the dedication of one's time and money has yielded a profit to the creators and it has become a source of encouragement for everybody.


Study Objective. To determine the value of fosphenytoin compared with phenytoin for treating patients admitted to an emergency department following a seizure.


A sensing and temperature control system structure is proposed that uses one thermoelectric module (TEM). The system was implemented in a solar testing environment to evaluate human body interactions. The solar simulator cast the sun-light on a petri dish, and a TEM sensed the temperature under the dish, heating or cooling the petri dish as required to ensure the appropriate temperature. Using this unique close-loop control structure solve the nonuniform temperature sensing and heating problem. Moreover, no external temperature sensing or controlling device is required. The proposed sensing and temperature control method can heat a petri dish from 28 °C to 37 °C in approximately 150s, demonstrating 0.2 °C temperature variations in a 6cm2 area.


Lack of time is an oft heard cry from clinicians; certainly when it comes to reading professional journals and research articles. So are there reliable sources of evidence available that assess and summarise recent evidence on wound topics that clinicians can check to ensure their wound care practice is current and safe? The answer is 'yes'.


The performance of bubble column reactors is dependent on bubble size that is formed through a sparger. Here, a single air bubble formation (BF) using an orifice in the viscous liquid is modeled by using the volume of fluid method. The interface between the air and the liquid phase is calculated by using the continuum surface force equation. Detailed characteristics of BF such as the instantaneous contact angle, bubble departure volume, bond number due to orifice size and surface tension, and capillary number are examined for different orifice sizes at constant air flow rate boundary condition. The numerical results are validated with available correlation and experimental data for orifice bond number reported in the literature. A comparison of BF characteristics between in the viscous liquid and in the water is examined. The instantaneous contact angle decreases steeply for the orifice with small size than a large orifice. The bubble volume increases with increasing contact angle and decreasing the orifice bond number. In comparison with water, a decreasing detachment time and dome width of bubble and an increasing bubble neck elongation are found in viscous liquid and decrease with increasing bond number. Moreover, there is a minimum capillary number, where the bubble neck elongation height and breakup processes are relatively fast. This study can helpful in designing a coarse gas sparger to develop pseudo-homogeneous bubbly flow regime at lower superficial gas velocity conditions.


In recent years two incompatible views of Kant's deduction of pure judgments of taste have emerged. Some commentators have argued that the task of the deduction is incpmplete until the Dialectical portion of the "Critique of Aesthetical Judgment" along with the Appendix, "Of the Method of Taste". The most notable contributors to this Interpretation are R. K. Elliott and Donald W. Crawford. The other view, perhaps "best represented by Paul Guyer, is that these latter stages of Kant's theory cannot legitimately be seen äs buttresses to the deduction, but only äs elements of Kant's theory which rely upon its success. The view for which I shall argue is in agreement with this. My understanding of what is required for the completion of the deduction is, however, not in agreement with Guyer's. I shall maintain that his Interpretation is mistaken in expecting the deduction to do more than Kant intended for it. Once the deduction is understood to stand or fall on the issue of whether Kant can establish the universality of what he calls a "common sense", it can come äs no surprise that this task must be pursued until the end of the Cntique. Thus, Guyer's view that Kant is attempting to deduce a common sense lends more credence to the views of Elliott and Crawford than Guyer is willing to allow. In what follows I shall try to establish that if the deduction is seen within its proper limits it ought to be appreciated äs contributory to the clarification of Kant's aesthetic theory, rather than to its obscurity.


This paper provides a brief review of research aimed at characterising the steel–concrete interfacial zone (SCIZ) and its influence on the susceptibility of the metal to pitting corrosion when concrete is exposed to environments that cause ingress of chloride ions accompanied by leaching of hydroxyl ions. For reinforced concrete made from Portland cements, exposed to aqueous solutions of sodium chloride, the buffering effect of solid calcium hydroxide (portlandite) at pH ∼12.6 has been shown to restrain the gradual decline in the hydroxyl ion concentration of the concrete pore solution phase at depths corresponding to the embedded steel. When the concrete is produced under laboratory conditions that are carefully controlled to exclude macroscopic defects from the SCIZ and the steel is cleaned before being embedded, this can lead to observed chloride threshold levels being consistently greater than 1% chloride by mass of cement. The buffering action of cement hydration products formed in the SCIZ is believed to be partly responsible for this high tolerance to chloride‐induced corrosion because it counters the generation of 'anodic acidity' that is a necessary condition for stable growth of pits to occur. Translating this behaviour of laboratory specimens to the performance of full‐scale reinforced concrete structures has often proved difficult in the past and there is a need for further research in this area, particularly in relation to the role of non‐traditional cements.


This article introduces the treatment of oil-bearing wastewater in the Natural Gas Processing Plant.The new oil-water separation technology is applied to solve the problem of safety and environmental protection that the oil-bearing wastewater is directly discharged into oil burning pool.The treated wastewater can be discharged meeting the requirements of standards,the light oil can be recovered and so the economic efficiency is increased at the same time.


This paper proposed a method of palmprint recognition based on SURF algorithm and OpenCV.Firstly,the image is binarized and the region of interest is segmented.The key points are extracted by using SURF algorithm,again random sample consensus(RANSAC) is used to match two feature sets.Finally,plenty of experiments are carried out to test the proposed method.The experimental results show that the system has good robustness to image rotation,translation,illumination and scale variations.