This thesis is dedicated to certain nonlocal aspects of conformal quantum field theories (CFTs). Two main directions are the study of CFTs on a particular globally-nontrivial spacetime corresponding to finite temperature, and the study of particular nonlocal CFT observables localized on light-rays. Specifically, we introduce bootstrap techniques for determining finite-temperature data of CFTs, and make novel predictions for the 2+1-dimensional Ising model. We propose the "stringy equivalence principle", stating that coincident gravitational shocks commute, as a generalization of the strong equivalence principle of Einstein's General Relativity that must hold in all consistent theories of gravity. We prove it in Anti-de Sitter (AdS) spacetimes by studying light-ray operators in the holographically dual CFT. We also derive an operator product expansion (OPE) for light-ray operators in CFT, by which two light-ray operators on the same light-sheet can be expanded as a sum of single light-ray operators. Light-ray operators model detectors — such as calorimeters. We use the light-ray OPE to compute energy event shape observables suitable for conformal collider physics. An additional part of this thesis determines the low-energy vacua of two-dimensional maximal super-Yang-Mills theory, which describes the dynamics of stacks of D-strings in Type IIB string theory. By computing an invariant of the renormalization group (RG) flow from high to low energy — a modified thermal partition function named the refined elliptic genus — we prove the existence of multiple vacua, and identify the superconformal field theories capturing their dynamics. The vacua correspond to bound states of (p,q)-strings in Type IIB string theory. Our computation serves as a check of the strong-weak S-duality of the Type IIB string.


This study aimed to analyze the mechanical properties of the compound FeCuC when compacted at varying pressures and sintered in two different types of furnaces. Besides the different models of furnace, the working atmospheres were varied: one is being composed with argon gas and another constituted with a balancing nitrogen and hydrogen. Atmospheres vary with the amount of production and the type of equipment used. The compound generated is used in the manufacture of rings for mechanical seals and is currently manufactured by the sintering process in passing furnace. The sintering was performed in a static furnace with argon atmosphere and compared with the same compound sintered in passage furnace with hydrogen and nitrogen atmosphere. The analysis of the properties of the tested material was performed with the aid of metallography using a scanning electron microscope, which verified the particle size distribution, chemical elements and pores present. Brinell hardness and Vickers micro hardness tests were also used to analyze the properties of this material after completion of the two processes. Thus, the research carried out has shown that variations may occur in the mechanical properties when processed in different furnace types and different sintering atmospheres.


Objective To explore the experience in prevent obturator never reflex during transurethral resection of bldder tumor.Methods The clinical data to prevent obturator never reflex were collected in 186 cases bladder tumor patients during transurethral resection of bladder tumor from 2004 to 2007.The patients were divided into three groups:first group used epidural anesthesia and muscle relax during with oxygen by facepiece in 122 cases.second group used general anesthesia in 42 cases.third group used epidural anesthesia never blockage method in 22 cases.Results 10 cases patients in first group occurred slight obturator never reflex and not bladder perforation,severe obturator never reflex occurred in 5 cases patients,slight perforation in 4 cases severe perforation and severe bleeding in 1 case,the bladder repair operation were done.Obturator never reflex in 2 cases occur in second and third group patient.Conclusion Epidural anesthesia could not blockage obturator never reflex.The muscle relax drug can block the contraction of bladder muscle,this method is useful for little bladder tumor or short time TUR-BT operation actually.The general anesthesia is suitable for large bladder tumor,multiple bladder tumor or long time TUR-BT operation.The manage of used dose and maintained time of muscle relax drug is very important during first or second group,the lower used dose or short maintain time can develop obturator never reflex and bladder perforation during TUR-BT operation.The obturator never block and epidural anesthesia is economical method.


Strokes is a public health problem due to their direct annual costs relating to hospital care, related fees and their indirect annual costs linked to the consequences of remaining disability. Stroke is one of the leading causes of morbidity and mortality worldwide. Therefore, epidemiological studies in different parts of the world are needed. The overall objective of this study was to describe the epidemiology of stroke of patients received at the neurology unit of the Retirement Care Center of Dakar in IPRES. It was a retrospective study conducted from January 2010 to April 2016, using patient's medical files. Among 1400 consulted patients, 275 (19.6%) were enrolled in our study. The mean age was 71.8 ± 8.7 years old (extremes: 43-101) with a male predominance (66.2%). Concerning the brain CT-scan, 243 patients (88.4%) presented cerebral infarct. The main risk factors were high blood pressure HBP (80%), diabetes (17.1%) and history of stroke (14.2%). Frequent complications encountered were epilepsy (11.5%) and vascular dementia (8.7%), motor disability (6.5%) and stroke recurrence (6%). Approximately 22 deaths have been noted giving a lethality rate of 12.02%. Most patients (54,44%) experienced clinical improvement. Stroke represents a major public health problem. It is therefore necessary to fight against stroke by early diagnosis and management of risk factors including HBP, especially among the elderly.


This paper presents a low-cost proposal for the development of a remote laboratory, offering the possibility of providing to learn in the field of robotics for users with no need to be physically in the laboratory, or simply not having to take the robotic platform to reprogram it. It also gives the option of working with the same platform to a group of users to test their algorithms by turns. The system is based on a Wi-Fi router updated with a Linux firmware connected to a control board that manages the hardware of a mobile robot. The microprocessor has also been loaded with the Player Server environment, which is widely used in commercial robotic platforms for research.


Achieving a good treatment outcome in rheumatic diseases (RD) requires regular, dynamic patient monitoring and therapy correction if it is not effective or intolerant. The patient assessment must be based on clear criteria to objectify the main manifestations of the disease. For this purpose, the calculation of standard activity and severity indices (DAS28, CDAI, SDAI, BASDAI, ASDAS, DAPSA, PsARC, PASI, etc.) is used. However, this methodology does not always allow the assessment of the fundamentally important parameters of treatment outcome – patient satisfaction and well-being. According to a series of studies, poor therapy satisfaction may be observed in ≈25% of patients with systemic RD who are in remission/low disease activity according to standard indices. Moreover, in 20–30% of cases there is a major discrepancy in the assessment of therapy outcome between the patient and physician. Therefore, a more accurate assessment of the patient's condition requires, in addition to the calculation of standard indices, the mandatory analysis of patient-reported outcomes – pain, functional impairment, general assessment of disease activity, fatigue, etc. A valuable tool for determining well-being and good therapy outcome from the patient's point of view is the PASS ("patient acceptable symptom state"). This simple and quite informative index correlates well with core symptoms and indicators of remission/low disease activity. PASS analysis can be used in telemedicine follow-up of patients when an objective examination is not possible. The combined use of PASS and standardized indices can better assess treatment outcomes and improve the quality of life of patients with RD.


The simultaneous enantioseparation of a basic drug compound, 2(R)-N-[1-(6-amino-pyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenyl-acetamide (M3), and its chiral acidic intermediate, (R,R) 1-(2,2-difluorocyclopentyl)-phenylacetic acid (MA), was investigated by capillary electrophoresis (CE) with various cyclodextrins (CDs). After an initial screening, a single-isomer CD, octakis(2,3-diacetyl-6-sulfo)-gamma-CD (ODAS-γ-CD), was selected for further method development based on separation selectivity and the peak migration time. Other method parameters such as pH of background electrolyte (BGE), type of capillary, temperature, and organic modifier were varied in order to optimize the method. The optimal method was validated in terms of linearity, sensitivity, precision, ruggedness, and specificity. A mixture of enantiomers of M3 and MA were spiked into a matrix of reagents used for the synthetic step and the resulting solution was evaluated by the optimized CE-chiral method. The results indicate both pairs of M3 and MA enantiomers were free of interference from the reaction matrix. Therefore, the feasibility of utilizing the method to monitor possible enantio-conversion during the synthetic process was demonstrated.


The social history of élites and the bourgeoisie must be one of the most popular areas of French historical research at the present moment, after a long period of neglect. It may be useful to look first at the reasons for this previous distrust and present enthusiasm so as to trace the main directions of contemporary research.


The vapor−liquid equilibrium behavior of tolan in alcohol was measured at atmospheric pressure in the dilute composition range of tolan with a recirculation still. Equilibrium compositions were determined with an ultraviolet spectrometer. The reliabilities of the compositions in the liquid and vapor seem to be ±2 × 10-5 and ±2 × 10-7 mole fraction of tolan, respectively. The accuracies of temperature and pressure are ±0.01 K and ±0.01 kPa, respectively. The volatilities Ki = yi/xi of tolan at infinite dilution were determined to be 0.0033, 0.0029, 0.0031, and 0.0054 in methanol, ethanol, 2-propanol, and 1-propanol, respectively.


printing supported by . Visit Chiesi at Stand D.30 SUNDAY, SEPTEMBER 25TH 2011 FEV1 values were 4.1% larger than the predicted values in the whole group. For 31 subjects (58.5%) measured FEV1 values were outside the 95-105% interval of FEV1 predicted values. Conclusions: A significant number of healthy adults have had spirometric values outside the confidence interval of predicted values (European equations in use). A larger study is needed in subjects with different ages and heights to verify the data obtained in our study. The opportunity of determining specific predicted values in a large populational study is discussed, considering the necessary resources. P1208 E-patient reported outcomes: Can you have reliance on compliance? Aleck Harrison1, Grant Sowman2, Hardip KaurNagra2, Richard Woodward2. 1Clinical Operations, AJH Partners, Wallingford, Oxon, United Kingdom; 2Clinical Trials, Vitalograph Ltd, Maids Moreton, Buckingham, United Kingdom Introduction: Consistent evidence is required to confirm the value of electronic Patient Reported Outcomes (e-PROs) for compliance in Usage and Quality of PEF manoeuvres in large clinical trials where these data are used as critical end-points [1]. Method: In an international asthma trial requiring twice daily symptom scores and three PEF manoeuvres over 105 days e-PROs were recorded using the Vitalograph PEF/FEV e-diary within a protocol specific program. Usage Compliance was assessed by the actual number of completed sessions made by patients as a percentage of the potential total. Quality Compliance assessed by Repeatability of the two highest manoeuvres of a session using the ATS/ERS standard of ≤40 L/min. Results: From 519 asthmatic patients at 78 sites a total of 103,198 diary sessions were made. Compliance during screening was 93±7%, treatment 88±13%.and overall 89±8%. Three manoeuvres were recorded in 99% of the sessions. Repeatability Compliance of PEF for both screen and treatment periods was 88%. The difference in PEF between the two highest manoeuvres was 13.85±10.3L/min. There was no statistical difference between the morning and evening data. Conclusion: These data concur with other previously published [2]. Thus e-PROs from asthmatic patients are consistent for both quantity and quality and have statistical reliance as the primary end-points for future trials. References: [1] Johnston N. et al. The promise of electronic data capture in respiratory medicine. Eur Respir J 2011; 37: 228 [2] Harrison AJ et al. E-diary compliance in two pharmaceutical trials. Eur Respir J 2009; 34: E1854 The sponsors of this trial are thanked for the anonymous use of their data. P1209 Comparison of referral patterns between a respiratory laboratory in the Republic of Ireland and Western Australia Elizabeth Salamon1, Maria Stack2, Kevin Gain1. 1Respiratory Medicine Department, Royal Perth Hospital, Perth, Western Australia, Australia; 2Respiratory and Sleep Laboratory, Cork University Hospital, Cork, Ireland Background: Respiratory diseases account for 13% of deaths in the Republic of Ireland (ROI), and 8% in Western Australia (WA) each year. County Cork has a population of 0.5 million and is serviced by Cork University Hospital (CUH), one other public, and one private hospital laboratory. CUH has 815 beds and is the principle teaching hospital. Located in the city centre, Royal Perth Hospital (RPH) is the largest teaching hospital (855 beds) in WA, which has a population of 2.2 million. This area is also serviced by three other teaching hospitals, and numerous private laboratories.


After Brown: The Rise and Retreat of School Desegregation. By Charles T. Clotfelter. Princeton: Princeton University Press, 2004. 216p. $24.95. Boom for Whom? Education, Desegregation, and Development in Charlotte. By Stephen Samuel Smith. Albany: State University of New York Press, 2004. 246p. $86.50 cloth, $29.95 paper. Charles Clotfelter was moved to write his book because he discovered that his students at Duke had no real appreciation of the intense struggle to end racial isolation in public schools begun by the 1954 Brown v. Board of Education decision. He felt some urgency in laying out the historical record since there were strong indications that contemporary schools were becoming resegregated. After Brown focuses on "interracial contact," the physical proximity of the races in schools, because it is the necessary intermediary for all other potential benefits, including educational achievement, self-esteem, attitudes, and long-term social and economic success.


Consumers concerned about their health are changing their dietary habits. Yet most are unaware of the potential nutritional value of bread, which makes up a major part of their diet. However, comprehensive information concerning this topic is not readily available. This paper compares the nutritional characteristics of organic, freshly stone-ground, sourdough breads with conventional breads, highlighting the factors which inhibit or enhance its nutritional value. A brief history of wheat, its milling, and bread-making are included to enable the reader to better understand factors that are responsible for the decline or the improvement of the nutritional quality of bread.


This paper focuses on joint decision making about pricing and inventory in a three level supply chain composed of multi suppliers, one supply-hub and one manufacturer. The problem is modelled as a three-stage game. Firstly, the manufacturer determines its margin. Secondly, the supply-hub determines its replenishment policy. Finally, each supplier determines its wholesale price, production lot size and delivery lot size to the supply-hub. An analytical and computational method is proposed to solve the game model. A numerical study has been conducted to demonstrate how the algorithm works and to understand the influences of decision variables and profits of the three entities, we draw some management insights through this study.


Based on the converse thinking,the motion law of the selected follower was taken as the design objective,the relative formulae of the parameters of the groove cam were derived.Based on this,combined with the parametric function of Pro/E,the central track program of swing link roller was compiled.Finally,the automatic design of the planar groove cam was realized.


To obtain a number of advantages in fabrication, testing and alignment, many designs in which spherical mirrors replace classical Cassegrain-form aspheric mirrors are present in the literature. However, spherical mirrors suffer from substantial spherical aberration and thereby require some form of corrector group. But in this case, the question encountered is that of making the basic optical configuration more complex. In this paper, a new design based on Cooke corrector group is presented for eliminating spherical aberration, which is believed to provide higher performance with less complexity than previous approaches. Besides, the cost and fabrication period will be extremely decreased. The telescope system using corrector group here can achieve good optical performance with f# of 10, full field of 0.5°, obscuration of 1/3 and MTF (Modulation Transfer Function) of 0.48 corresponding to 50@lp/mm.


Use of Robotic manipulators is wide spread in Mechanical Industries. Serial Manipulators take the major share in this aspect. Rigid Body dynamics is an efficient tool for estimating effect of inertial loads on joint torques and thus help in generating a better control system for robotic manipulators. In the current work, the use of Rigid Body Dynamics using the motion analysis package in commercial software (Solidworks) is used. The results are verified analytically. Rigid Body Dynamic Analysis are also performed on 3DOF planar manipulator and 3DOF spatial manipulator. The results of simulations of 3DOF spatial manipulators are taken as input for stress analysis using FEA.


The demand for wireless applications with high data rates and strict quality of service (QoS) requirements continues to grow. This has placed huge obligations on wireless service providers to meet this need when rolling out radio access networks (RAN) in order to meet these capacity and coverage requirements. A distributed antenna system (DAS) is a RAN architecture that improves both coverage and capacity for both `dead-spots' and `hotspots'. In this paper, we investigate the energy efficiency gains of DAS in the case of non uniform user distributions. This investigation is conducted for outdoor hotspot scenarios and results show that the energy reduction gain (ERG) of DAS when Remote Radio Heads (RRHs) are located coincident with the hotspots improves with increasing numbers of users per hotspot as well as with increasing transmit power of the RRH. When RRHs are deployed coincident with hotspots, energy savings of 20% can be achieved. This is in contrast to the case when they are not, where losses of energy efficiency can be observed to result from the use of DAS.


Abstract Trade between resource‐poor Mesopotamia and the resource‐rich Iranian highlands played an important role in the rise and maintenance of the earliest civilizations in the Tigris‐Euphrates valley. This paper examines the development of that trade from the perspective of the Iranian resource areas. A methodology for the study of trade development is discussed, emphasizing the importance of knowing source areas. Iranian sources for alabaster, marble, obsidian, steatite (chlorite), carnelian, lapis lazuli, turquoise and copper are noted. Evidence for the development of trade between 4500 and 3000 B.C. at the site of Tepe Yahya is examined in detail. A developmental typology of trade is presented, and some possible causal factors ‐ such as the by‐pass phenomenon ‐ are suggested for this development.


The cost-benefit analysis (CBA) is an useful tool for evaluating and making decisions about different investment projects. But the cost-benefit analysis takes into consideration the costs and the benefits as a unitary body, considering these costs and benefits for all those involved at once and disregarding the fact that the costs could be supported by persons that are different from those who enjoy the benefits. It also does not take into consideration the fact that the benefits that someone enjoys are not moral if another person may suffer from that action that leads to benefits for other person or persons. The cost-benefit analysis just sums the costs and the benefits and if the latter exceed the former, than the conclusion is that the project is a viable one and that it should be implemented. Is it so?


The study and solution of the problem of informatization of higher education, which is that as a result, global rationalization of intellectual activity in education through the use of artificial intelligence should be achieved in order to increase the efficiency and quality of training specialists to the level of information culture. Ability to use artificial intelligence systems in the learning process allows you to have an idea of the object of knowledge, and helps to master all the diversity and complexity of relationships characteristic of real processes, trace the dynamics of these relationships when changing external and internal factors. The article analyzes the use of information technologies as a factor for improving the quality of training of future specialists in higher education institutions and the actual problems of professional training of specialists and ways of their solution. The types of innovative teaching methods in higher educational institutions are investigated and the role of information and social technologies in education is considered. The peculiarities of the programmed educational facilities are revealed and the directions of use of information technologies in the educational environment are substantiated. The stated goal set the task: to analyze the possibilities of modern information educational technologies and to investigate the development of the concept of pedagogical innovation as an innovation in the field of pedagogy; to determine the possibilities of using artificial intelligence systems in order to implement a differentiated approach to students with different levels of training; to identify promising directions in the field of application of information technologies in the process of training future specialists in higher education institutions.


The viscosity of potting materials for electronic parts increases greatly when the inorganic filler is densely packed. A vaccum sand-casting system has been developed, in which filler containing resin is potted into parts that are prefilled with silica sand. Dense packing of inorganic filler in the potting materials can thus be achieved. Using this system, parts can be miniaturized as a result of improved thermal conductivity. More efficient production is made possible by the shortened process time and automation of this system.


The increase of data collection and analytics over the past few years the control over personal data has become an important issue. Control over data is the execution of privacy and the ability to protect the individual identity. Solutions to give consumers more control have failed in the past due to security and privacy concerns. On top of that is innovating in healthcare challenging because of the complex network of stakeholders involved, limited budgets and conservative culture. The current definition of control, being able to disclose information to others, is outdated. Due to the digitalization of our world where data is easily copied and shared with others, the definition is too limited. This thesis proposes a new measurable definition of control that constitute the access, bookkeeping of access (record), clarity of use, the possibility of decisions, effort to access and freedom to make decisions as components of control. Furthermore, the obstacles that currently prevent consumers to control their data are identified, and the possible gateways around those obstacles. Finally, practical functionalities are proposed for the implementation of a solution that takes into account the perspectives of different stakeholders in the healthcare industry. Blockchain technology is proposed as part of the infrastructure for the registration of consent to health data. The solution proposed in this thesis is an infrastructure that facilitates convenient control for the consumer by integrating health data from different sources (in and outside the hospital environment) and aggregates the data into a complete overview. Consent to the information is registered on the blockchain, to keep an immutable record of access authorization. The consumer is at the centre and can control who to share a part, or complete set, of their data with different stakeholders.


The gas-phase reactions of methyl formate with anions, , are studied theoretically using the AM1 method. Stationary points are located by the reaction coordinate method, refined by the gradient norm minimization and characterized by the determination of Hessian matrix. Potential energy profiles and the stationary point structures are presented for all conceivable processes. Four reaction paths are found to be possible: formyl proton and methyl proton abstractions, carbonyl addition, and process. For the most basic anion the proton abstraction path is favored, while in other case, , the carbonyl addition paths are favored. In all cases the process is the most exothermic, but due to the relatively high activation barrier the process can be ruled out.


The present invention discloses a thermal storage medium and its preparation method and application of nano polyhydric nitrate molten salt heat transfer. The present invention provides nano nitrate molten salt heat transfer polyhydric heat storage medium, characterized in that: it is a multi nitrate molten salt made with composite nanoparticle; the polyhydric nitrate molten salt mainly composed of potassium nitrate, sodium nitrate, of cesium nitrate and nitrite composition; said particles of nano particles of a metal or non-metal oxides. Polyhydric nitrate prepared in the present invention nano-molten salt heat transfer performance both molten salt thermal storage medium nitric acid, but also improves the safe operating temperature limit to 600 ° C, a wider temperature range, good thermal stability. Molten salt heat storage and heat absorbing heat storage medium of the present invention prepared in good capacity, thermal conductivity significantly improved heat transfer performance greatly increased, and can be widely used in the field of solar thermal power generation technology.


This article proposes guidelines for a consistent framework for developing and documenting hazard and safety analyses for the chemical process industries (CPI).


The market is one of the most important institutions in economic institutions. The functioning of market institutions as economic institutions that drive economic life can not be separated from the activities undertaken by traders and buyers. The formulation of the problem is, How the Socio-Economic Impact on Tente Market relocation. This study aims to describe the Impact of Market Relocation to Socio-Economic Conditions of Tente Market Traders. This research uses descriptive qualitative method.
The results of this study indicate that, there is a social change, which technically traders and locations trade from the old market move to new markets. In this market shift raises the impact, ie social and economic impacts such as manifestations, with the impact of manifestations, the impact behind them is the latency impact experienced by traders after the relocation of the market. And less intennya interaction that exists between old traders and new traders. The social impacts that arise are the lack of social systems, interactions and personal relationships. The emerging economic impact of declining income after occupying the new Tente market.


Kielce and Olsztyn are two different urban ecosystems. They differ from each other in terms of geological and climatic conditions, as well as spatial development and industrial past. The aim of this article is to assess and compare the degree of lead contamination of the natural environment in both cities based on the conducted tests of soils, as well as a common dandelion's roots and leaves. For this study's purpose, 60 samples of soils and common dandelion's roots and leaves were collected in each city, according to four land-use types, namely industrial areas, urban green areas, urban allotment gardens, and urban forests. Basic physico-chemical properties and concentrations of lead, i.e., total content and bioavailable content were determined in the soils, using speciation analysis. Lead concentrations in the roots and leaves of common dandelion were, in turn, determined using the ICP-OES method. By using kriging models, spots with excessive lead concentrations differing from the geochemical background were identified in each city. The number of spots was comparable for both cities; however, the values for this metal differed significantly. No relationship has been found between land-use types and concentrations of lead in soils and common dandelions. The results of the study, as well as statistical and spatial analyses show that this species may be recommended as an indicator for biomonitoring of urban environments.


Objective: To observe the changes in the expression of apoptosis regulating gene Bcl-2 and Bax at different time points after acute spinal cord injury.Methods:We randomly divided 56 Wistar rats into 7 groups.we made six groups of the 7 groups as acute spinal cord injury model,the other group was used as control.We evaluated motor capacity at 0h,4h,8h,24h,48h and 72h after injury.The spinal cord was taken and after the HE staining and TUNEL staining,the immunohisto-chemistry methods were used to study the expression of Bcl-2 and Bax.Results:After acute spinal cord injury,the motor capacity decreased.TUNEL-positive cells were found at 4h after injury,with a maximum presence at 8h after injury.At 24h after injury,the positive expression of Bcl-2 was maximal,and the positive expression of Bax was maximal at 8h after injury.Conclusion:In addition to necrosis,apoptosis phenomenon presents in rats spinal cord injury.The proportion of Bcl-2 and Bax in cells may influence upon apoptosis and pathological processes after spinal cord injury.


Choosing cement and lime as inorganic binder, stabled chromium slag and then did the tests of the compaction, unconfined compressive strength and the stability for studying it as road base material, perfected the base material mixture ratio design and comparatively analyzed its mechanical properties and environmental indicators.Tests and analysis show that cement stable chromium slag when inorganic binder used alone on the basis of the optimal mixture ratio, which is better to meet the using performance requirements as road base materials; Mechanical performance offered by lime stable chromium slag is a bit weak, while it can be obtained extra stability effect to plus a small amount of cement or fly ash.


Femtosecond laser direct writing is a three-dimensional fabrication technique that can be applied to produce integrated optical components with high spatial resolution or microfluidic channels when combined with HF etching. The same fabrication technique can thus be employed to produce monolithic optofluidic devices for sensing applications. One of the most common sensing schemes involves evanescent optical interaction; therefore, the channel must meet some requirements regarding surface roughness, which will depend on the laser writing conditions, as described in this paper. However, of more significance is the distance between waveguiding medium and microfluidic channel that must be accurately defined. This control can be achieved by monitoring the etching reaction of a waveguide grating written a few microns from the channel, as introduced in this paper. In addition to its function as an etching monitor, the grating can also be used as a coarse refractive index sensor device.


During a germplasm collecting trip to eastern Sudan in 1979, 4 samples were collected and subsequently identified as S. purpureosericeum subsp. dimidiatum (2n = 10), of which a description is given. During PMC meiosis, 5 bivalents formed


The purpose of this research aims to determine whether the training, work discipline and motivation effect on employee productivity CV. Sapu Dunia Semarang. CV Sapu Dunia is a company which is specification in employee management. The research method effected is Explanatory Research. The sampel research is 100 respondent use the Purposive Sampling, and the data collected with questionnaire. The research result show that the effect of variable training on employee productivity CV. Sapu Dunia Semarang was good. It is shown by 59,8 percent of respondents.Then, the effect of  work discipline was good too, it is shown by 57,9 percent of respondents, and 28,9 percent of respondents had thehigh work motivation on CV. Sapu Dunia Semarang. Based on the results of hypothesis testing significantly show that the effect of the training, work discipline and motivation on employee work productivity CV. Sapu Dunia Semarang The effect positive given by the training variable on employee work productivity that the effect evidenced through the test of 12.077 t count bigger than t table 1.985. Then The effect positive given by the work dicipline variable on employee work productivity that the effect evidenced through the test of 11.605 t count bigger than t table 1.985. And The effect positive given by the motivation variable on employee work productivity that the effect evidenced through the test of 6,315. F-test shows that effect of the training, work discipline, and motivation variable have effect on employee work productivity CV. Sapu Dunia Semarang. The score of standardized coefficients beta of the training, work discipline, and motivation variable is 0,406; 0,395; and 0,147. This is show that the training, variable have a bigger effect than the work discipline, and motivation variable


Release of adenosine diphosphate (ADP) from red cells may play an important part in promoting platelet adhesiveness. Characteristic changes in red cell properties are believed to occur following trauma. Platelets tested with red cells drawn after operation demonstrated greater adhesiveness than platelets from the same pool tested with pre-operative red cells. A greater increase in platelet adhesiveness occurred following operation when whole blood was tested than when ADP was added to platelet-rich plasma. The acute platelet response to operation which may be relevant to the inception of thrombosis (Bennett, 1967)may largely depend on facilitated release of ADP from red cells. Bennett, P. N. (1967). J. clin. Path., 20,708


This article reports findings from a phenomenological inquiry into how parents experience End-of-Life (EOL) photography around the death of their newborn in the neonatal intensive care unit (NICU) and in their lives beyond the hospital. The study involved semi-structured interviews with 10 parents who had experienced the death of their newborn within the last five years in the same NICU setting. All parents had participated in EOL photography, having photos taken by nurses, by themselves, and/or by volunteer professional photographers. Through an Interpretive Phenomenological Analysis, the theme of "living relationships" emerged, revealing the photography as valued more than for the photos as "mementos," but further as an activity grounding relationships and fostering interaction between families, newborns, and care-providers; these findings provide insight into how parents came to see their EOL photos as "prized possessions." The article is concluded with a discussion on a Model for Photographing Living Relationships.


The cationic ruthenium-hydride complex catalyzes dehydrative C-H coupling reaction of arylamines with 1,2-diols to form the indole products. The analogous coupling of arylamines with 1,3-diols afforded the substituted quinolines. The catalytic method directly forms these coupling products in a highly regioselective manner without generating any toxic byproducts.


A handful of automakers are taking part in a trial for connected and self-driving carsin the United Kingdom as part of a government-backed initiative called Autodrive.


We propose an optimal MMSE precoding technique using quantized signals with constant envelope and PSK modulation. Unlike the existing MMSE design for 1-bit resolution, the proposed method employs uniform phase quantization and the bounding step in the branch-andbound method is different in terms of considering the most restrictive relaxation of the nonconvex problem, which is then utilized for a suboptimal design also. Numerical simulations show that using the MMSE criterion instead of the established maximum distance to decision threshold yields a lower BER in many scenarios and a smaller average number of bound evaluations for low and medium SNR.


Conscious consideration of risk allocation must be paired with asset allocation if diversification is to have its full impact on a portfolio. Among the trends in portfolio structuring is the use of hedge funds to find additional sources of active risk premiums by separating active from systematic risk, although data indicate that hedge funds are not entirely free of systematic risk. Other trends for managing risk include economic diversification, alpha-concentrated strategies, and alteration of portfolio constraints.


During the recent two decades, reduced accessibility to basic public goods has become a common problem in most of the inland provinces, and it is particularly the case in the lessdeveloped regions. In response to this situation, the local government in Tibet has secured the normal operation of the agricultural support system, strengthened investment in primary education and basic health care, and has guaranteed social assistance to the key vulnerable groups. There are two main reasons for this. Firstly, it is considered that substantial regional aid enables the local government to perform its public function with adequate fiscal resources. Secondly, external supervision has driven the local government to maintain sufficient political will to provide low-income groups with the basic public services at low prices or free of charge. This is essentially a type of investment-oriented income redistribution.In both the short and long term, it will contribute to reducing the economic inequality that the market mechanism has brought about. In other words, it will help to narrow the regional,sectoral and individual economic gaps.


Exogenous recombinant human erythropoietin (rHuEPO) is a beneficial therapeutic agent for correction of anemia in chronic kidney disease (CKD), end-stage renal disease, chemotherapy, and has been used as prophylaxis to prevent anemia after surgery. The erythropoietin receptor is widely distributed in the cardiovascular system, including endothelial cells, smooth muscle cells and cardiomyocytes. RHuEPO has potentially beneficial effects on the endothelium including cytoprotective, mitogenic and angiogenic activities. Early studies in heart failure patients with anemia suggest that rHuEpo therapy is safe and effective in reducing left ventricular hypertrophy, enhancing exercise performance and increasing ejection fraction. The use of rHuEPO, however, may also be associated with distinct side effects. Although not clearly demonstrated, a relationship between an increased red blood cell count and thrombus formation. Some reports suggest that rHuEpo may have prothrombotic or alters platelet aggregatory responses. Most notable is hypertension (HTN), partial correction of anemia with intravenous rHuEPO causes HTN. CREATE study found a trend toward increased mortality risk with a higher Hb target of 13-15 g/dl. Therefore aiming for a higher hematocrit level is still a controversial issue in the management of anemia in renal failure. Despite some potential adverse effects further studies are needed to define the role of rHuEPO in chronic cardiovascular settings. by the use of recombinant human erythropoietin (rHuEPO) has been proven to be an effective treatment with several beneficial effects on exercise capacity due to reduction of hypoxia and improvement of cardiac function.[2] At present, rHuEPO is approved also for treatment of anemia caused by other conditions, including anemia-associated with renal failure, chemotherapy and HIV antiviral treatment or to reduce the need for transfusion in preoperative surgical patients. However, beside these beneficial effects, potential risk factors of a rHuEPO treatment have been reported. Treatment with rHuEPO has been linked to an increased risk of thrombotic events, and EPO seems to affect various cardiovascular and hemostatic parameters unrelated to increase in hematocrit.[3] Thus, as the potential uses of EPO therapy increases, it is important to reconsider its cardiovascular effects. Biology of erythropoietin EPO is synthesized by peritubular cells in the cortex-medullary border of the kidney[4] and in the liver during fetal and neonatal development.[5]A variety of other tissues have been reported to express EPO including bone marrow macrophages,[6] trophoblasts,[7] breast glands,[8] and astrocytes[9]. Access this article online Website: www.sysrevpharm.org Quick Response Code: DOI: 10.4103/0975-8453.83438


Pediatric hearing loss is a significant problem that still warrants further attention by otolaryngologists. Systematic efforts to identify hearing loss in children are relatively recent. For example, prior to the implementation of the universal newborn hearing screen passed in Pennsylvania in 2001, only 50% of children in that state with hearing loss at birth were identified by risk factors. Considering that about 1 in 300 children is born with a hearing impairment and that 90% of hearing impaired children are born to hearing parents, the importance of the newborn hearing screen is clear. It is also clear that early intervention in these children, particularly by 6 months of age, improves receptive and expressive language skills independent of other variables. It is critical for all otolaryngologists not only to identify children with hearing loss but also to work them up appropriately and refer them for appropriate services. Approximately 25% of sensorineural hearing loss in children is from an acquired cause. Prematurity is perhaps the most significant perinatal risk factor, but other factors including NICU admission, intubation, low birth weight, low Apgar score, severe hyperbilirubinemia, and sepsis are all associated with sensorineural hearing loss. Infectious causes should also be explored, particularly intrauterine exposure to cytomegalovirus, herpes, rubella, syphilis, toxoplasmosis, and varicella, as well as meningitis in the postnatal period. Maternal teratogens that are associated with hearing loss include alcohol or drug abuse, methyl mercury, and thalidomide. Maternal use or perinatal exposure to ototoxic medication also can cause hearing loss in a newborn. Most commonly this is aminoglycoside exposure, but loop diuretic and other ototoxic medications can be involved. About 50% ofsensorineural hearing loss is genetic in origin, with two-thirds nonsyndromic and one-third syndromic. Otolaryngologists should remember that


1. The Utilization of Natural Resources2. Trade and Barter3. Social Structure4. The Position of Slaves5. Family Life6. The Maintenance of Law and Order7. Relations with Neighbours in Peace and War8. Religion and Moral Order


Rotational barriers in 1-fluoro-9-(1-naphthyl)fluorene and 1-fluoro-(2-methyl-1-naphthyl)fluorene were found to be lower by ca. 0.5 kcal/mol than those of their parent hydrocarbons. The results are attributed to raising of the ground state energy due to introduction of the fluoro group.


Concern about the ongoing availability of adequate supplies of water of suitable quality has motivated a long history of evolving legal and administrative approaches to water management. I take it that this session is motivated by the prospect of further change, e.g. the recent proposals of the Saskatchewan government. To provide a perspective on the allocative implications of alternative institutions, this paper surveys - selectively - some recent economic and legal literature from a Canadian viewpoint. We find that a mixture of technological limitations and institutional rigidities prevents water users from taking into account their interdependencies and opportunities for mutually beneficial water transfers.


![Graphic][1]

Many patients with myelofibrosis (MF) develop anemia and are, or become, dependent on frequent red blood cell transfusions [1]. Results from the phase 2 studies for the treatment of myelofibrosis (MF) with the Jak1/2 inhibitor momelotinib (MMB) demonstrated that MMB treatment provided an anemia benefit, in addition to providing a durable spleen response and improvement in constitutional symptoms in MF patients [2]. MMB's anemia benefit was an unexpected outcome as erythropoietin (EPO)-mediated JAK2 signaling is essential for erythropoiesis [3, 4]. Systemic iron homeostasis is controlled by the peptide hormone hepcidin produced by the liver. Hepcidin reduces iron export from duodenal enterocytes and splenic and hepatic macrophages by binding to and down-regulating the iron exporter ferroportin [5-7]. In chronic disease, there is a significant increase in hepcidin levels which can result in severe anemia; this pathologic condition is termed anemia of chronic disease (ACD). Recently, MF patients have been shown to have elevated serum hepcidin levels and this increase is associated with inferior overall survival in these patients [8].

This study aimed to determine whether MMB's clinical anemia benefit is driven by direct activity of MMB on the hepcidin pathway. We assayed MMB inhibitory activity on the BMP-receptor kinase pathway (the central driver of hepcidin transcription in hepatocytes) and assessed the activity of MMB in a rodent model of anemia of chronic disease (ACD). We demonstrate that MMB inhibits BMP6-induced in vitro production of hepcidin in cultured hepatocytes (HepG2 cells) with an EC50 = 651 +/- 203 nM (n=3). This inhibitory activity is mediated by direct suppresion of the BMP-receptor kinase Alk2 as MMB inhibits Alk2 enzymatic activity with an IC50 = 8.4 +/- 1.5 nM (n=3). Ruxolitinib has no activity on either Alk2 or the BMP-receptor kinase pathway. To understand whether MMB could modulate hepcidin levels in vivo and ameliorate anemia in vivo we assessed the effect of MMB in a peptidoglycan-polysaccharide fragment (PG-APS)-induced rat ACD model. Treatment with clinically relevant exposure levels of MMB for 3 days resulted in a dose dependent reduction in both liver RNA and serum protein hepcidin levels and caused an increase in serum iron. Furthermore, long-term treatment with MMB for 21 days increased the numbers and percent of reticulocytes and mature red blood cells in the bone marrow and increased Hgb and hematocrit to normal levels in the blood.

Our data suggest that MMB's clinical anemia benefit results from inhibition of ALK2-mediated expression of hepcidin in the liver, which results in increased release of iron from sequestered cellular stores and enhanced erythropoiesis. A phase 2 translational study in anemic subjects with MPNs is scheduled to confirm this mechanism. The Alk2-mediated activity on iron metabolism through hepcidin could prove beneficial in a number of additional indications, and facilitate the combination of MMB with myelosuppressive agents.

1. Tefferi, A., et al., One thousand patients with primary myelofibrosis: the mayo clinic experience. Mayo Clin Proc, 2012. 87 (1): p. 25-33.

2. Pardanani, A., et al., Update On The Long-Term Efficacy and Safety Of Momelotinib, a JAK1 and JAK2 Inhibitor, For The Treatment Of Myelofibrosis . Vol. 122. 2013. 108-108.

3. Verstovsek, S., et al., Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med, 2010. 363 (12): p. 1117-27.

4. Verstovsek, S., et al., A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med, 2012. 366 (9): p. 799-807.

5. Nemeth, E., et al., Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, 2004. 306 (5704): p. 2090-3.

6. Theurl, I., et al., Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease. Blood, 2006. 107 (10): p. 4142-8.

7. Theurl, I., et al., Autocrine formation of hepcidin induces iron retention in human monocytes. Blood, 2008. 111 (4): p. 2392-9.

8. Pardanani, A., et al., Associations and prognostic interactions between circulating levels of hepcidin, ferritin and inflammatory cytokines in primary myelofibrosis. Am J Hematol, 2013. 88 (4): p. 312-6.

Disclosures Warr: Gilead Science: Employment. Maciejewski: Gilead Science: Employment. Fowles: Gilead Science: Employment. Whitney: Gilead Sciences: Employment. Theurl: Gilead Science: Research Funding.

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Dr. Calnan discussed worker's compensation laws in England and how they influence the reporting of occupational health information. Important barriers to obtaining accurate information on occupational skin disease were discussed. Measures were recommended that could improve the process of information gathering.

See Calnan CD (1983): Occupational health reporting systems in England. Dermatosen in Beruf Umwelt 31 (5): 154–158.


It is not uncommon for legislatures, in fabricating labor law protections, to permit unions to agree to derogate downward from them – to dispossess the workers they represent of rights the workers would enjoy were they not to be union-represented. This is so, for example, of the United States and Germany. This article explores labor dispossession in these two jurisdictions: on what matters, for what reasons, with what consequences and subject to what cautions is collective derogation allowed; and to see what conclusions can be drawn that are generalizable across these jurisdictions or that are cabined to them.


A polarization-independent graphene-based electro-absorption optical modulator concept is presented. The device is based on a slanted silicon stripe upon which two graphene flakes reside; on this surface, another silicon waveguide is capped, forming a rectangular silicon-graphene waveguide (SGW). Simulation results show that effective mode index of both TE and TM modes in the SGW undergo almost the same variations under different biases across a broad wavelength range. For a 30-μm-long silicon-graphene waveguide, throughout the S, C, and L communication bands, extinction ratio (ER) higher than 20 dB can be obtained by proper choosing of switching points for "ON" and "OFF" states. The ER discrepancy between TE and TM modes is smaller than 2.3 dB, and the polarization dependency is lower than 0.1 dB for "ON" state, which fulfills the requirement of polarization-independent modulation. Calculations show that the 3-dB modulation bandwidth higher than 100 GHz of our modulator is possible.


In this talk I will give an overview on three different ways to adress a Fluid–Structure Interaction (FSI) problem: all the work presented is considered within the framework of Model Order Reduction. We start with a monolithic algorithm that is used for a FSI problem that is transport dominated: the corresponding solution manifold has a slowly decaying Kolmogorov n –width, and this repre-sents an issue for the Reduced Basis Method (RBM), as it affects its efficiency. For this reason I present a preprocessing procedure, carried out in the offline phase of the RBM, that allows to decrease the Kolmogorov n -width of our problem. I present results that show the comparison of the performances of the classical offline stage and the new offline stage of the RBM, for the FSI problem of interest. In the second part of the talk we focuse on a partitioned approach to FSI problems. We present an algorithm that is based on a semi-implicit coupling scheme with Robin type boundary conditions, taking into account both an ALE formulation, a geometrical parametrization of the domain and a physical parametrization as well. Finally we change a little bit the mathematical framework, and we move from standard FEM discretization to an unfitted mesh discretization. I show preliminary results concerning the application of CutFEM to two problems: a Stokes and a Navier–Stokes problem formulated over a domain that is caracterized


The sum‐delay amplifier and the gate generator are in separate single‐width NIM modules. The amplifier has five input channels which can be switched in or out. The delay can be switch selected to be 0, 1, or 2 μsec. The gate generator is very flexible. It will accept almost any type of input signal and produce an output pulse which can be adjusted to meet most gating requirements. One frequent use of the instrument is to observe the performance of an electronic system while an experiment is being performed.


This report is to illustrate the yield and the balance of utilization of the RDF produced at the Fusina integrated pole, comparing it with what is known about the waste combustion in incineration plants. The material and energy balances resulting from a monitoring during twelve years or running are to be used in the following comparisons. Those balances prove the convenience of the process from the energetic point of view, also considering that the privileged outlet for the co-combustion of the produced RDF will be the thermo electrical power plant of Fusina.


The concepl of Minimum QU811tity Lubrication (Mal) sometimes referred to as near dl)' lubrication or micro lubrication has been advocated since a decade ago as a me8rlS of addressing the issue of environmer'llal troublesome. Minimum Quantity Lubrication mentions to the use of cutting fluid of only a Iiille amount usually of a flow rate of 50 to 500 ml/hour-which is about tllree to four orders of scale lower than the amount commonly used in flood cooling condition, lor example, up to 10 liters of fluid can be supplied per minute. Saving lubricant costs and tool Iworkplece/machine cleaning cycle time the minimization of cutting fluid also leads to economical benefits. A number of studies have showr'l that MQL machining can show saliSfactory performance in praclical machining operations. But, there has been lillie Investigation of the cutting fluids to be used in MQL machining. In this regard the proposed research work has been earned out with a view to study the effects of Minimum Quantity lubrication (MQl) by water soiuble cutting fluid on the cutting performance of medium carbon steei, as compared to completely dry and wet machining in terms of tool wear reduction, tooi iife increment and machined surface mtegrlty, Based on the procesS parameters (speeds, feeds and depth of cut) an approach has also been performed to recognize the apt MQL nozzle position for better coohng aellon, In the study, the minimum quantity iubrication will be provided with a spray of air and water soluble cutting fluid. Significant progress


The judicial reform in China calls for genuine and thorough judicial independence,of which prosecutorial independence with Chinese characteristics is an important part.Chief prosecutor system is an effective way of achieving internal independence in prosecutorial independence.This paper aims to reveal the important features of Chinese judicial independence on an analysis between thorough independence and restrictive independence in the system of chief prosecutor,and look forward to the gradual perfection of the system.


We document leukostasis leading to acute fatal right‐sided heart failure. In patients presenting with leukostasis and cardiopulmonary symptoms, clinicians should aim to assess for cardiac involvement, that is, by ECG and acute echocardiogram, since early recognition of right ventricular disease may provide an opportunity to treat this potentially reversible condition.


In the age of knowledge, human learning at work has been a growing focus of attention by some theorists and researchers in the fields of Business Administration and Psychology. In this context, learning strategies at work emerge as one of the decisive elements for the optimization of the learning processes of individuals in organizational environments. In this study, the experience of making an exploratory mapping of the individuals' learning strategies is reported, the goals of which were to classify sixteen professional occupations into four categories of work positions and also to describe and compare the strategies used by these individuals for learning in their daily lives at work in their different professional fields. In order to achieve this, the sample was composed of twelve coordinators in the area of Human Resources and 55 representatives of the sixteen professional occupations under study. The data obtained showed that the strategies of Practical Application and the Search for Interpersonal Help played a central role in the processes of acquisition, retention and transference of new knowledge, abilities and attitudes at work, and also that different configurations of uses of learning strategies were associated with the professional categories studied


Objective: The role of interleukin(IL)-17 in cellular communication in inflammation has been well described, and a positive correlation between the severity of periodontitis and the level of IL-17 was reported. Although epithelial cells are a major target of IL-17, little is known about the effect of IL-17 on the production of chemokines by human gingival epithelial cells(HGECs). The effects and the mechanism of IL-17 have been evaluated on the expression of CXCL8 and CCL2 by HGECs. Methods: After IL-17 stimulated the human gingival epithelial cells, We evaluated the effects of IL-17 on the expression of CXCL8 and CCL2 by HGECs using ELISA. In addition, the role of the nuclear factor(NF)-κB signalling pathway in the IL-17-mediated expression of chemokines was assessed using a specific inhibitor by WESTERN BOLT. Results: Comparing no stimulation of IL-17 group with under stimulation of IL-17 group, the secretion of CXCL8 protein had significantly increased. And the protein expression of p-IκB significantly increased indicate the activation of NF-κB(P0.05). Meanwhile, comparing stimulation of IL-17 group with stimulation of IL-17 plus the inhibitor of NF-κB group, the secretion of CXCL8 protein had significantly dcressed. And the protein expression of p-IκB significantly decressed indicate the inhibition of NF-κB(P0.05). Conclusion: IL-17 is involved in the regulation of the innate immune response in HGECs by inducing CXCL8 production and the NF-jB signalling pathway is involved, while it provides a new target for treatment of periodontitis induced by IL-17.


The taxonomic validity of two presumed species of the collembolan genus Dicyrtomina was evaluated by using allozyme electrophoresis. Twenty-one loci were screened in seven populations assigned to D. ornata and eight populations assigned to D. saundersi. The presence of loci fixed for alternative allelic patterns in sympatric populations demonstrated that the two species are reproductively isolated, therefore confirming their specific status. Average genetic distance between populations of the two species was D=0.714. Populations of D. ornata were more differentiated from one another with respect to those of D. saundersi, which showed higher levels of gene flow.


Commemorations of the Great Peace. This event occured in Montreal in 2001 at Pointe-a-Calliere, Montreal Museum of Archaeology and History.


The aim of this exploratory study is to estimate the relationship between vitamin D (vit D) deficiency and active rheumatoid arthritis (RA), and the role of supplementation in improving disease activity.


In college English teaching,carrying out quality-oriented education is a major task.However,in university,middle and primary school,English teaching is disconnected,examination-oriented education is rather serious.It is discussed in this paper that college English reform mainly lies in understanding the nature of quality-oriented education,reorganizing teaching of different levels,changing teaching pattern,enhancing teachers training,and furthering bilingual education as well in order to raise quality-oriented education.


 In the present study, the hydrodynamic and heat transfer characteristics of compact fin andtube heat exchangers have been investigated numerically. The aim is to analyze the influence of operating conditions and the geometry parameters of compact heat exchanger to design more efficient heat transfer device. Fin spacing and fin thickness are the geometrical parameters.The over-fin fluid velocity or Reynolds number is used as the parameter of operation. Here in this work it finds the effect of different material, fin thickness and fin spacing on heat transfer enhancement of the compact heat exchanger. Here in this work four different Reynolds number that is 2622.96, 5248.98, 7873.25 and 10497.96 were considered to analyze the effect of different velocity of fluid. It also analyzed the effect of different materials used for the construction of Fin and tube, in this work three different steel alloys that is GH2132, GH3044 and S66280 were considered for the analysis in which GH3044 shows the better heat transfer as compared to other.For GH3044 material heat transfer rateis 15 % more than the GH2132 material. Whereas domain having 0.8 mm fin spacing shows 5 % increase in heat transfer as compared to 1.1 mm fin spacing.


In this paper,investigation,experimentation and mathematical statistics and so on,for the characteristics of female college students with insomnia,taking yoga physical therapy experiment,drawn: 1.After 12 weeks of yoga physical therapy,the college girls PSQI total average soil from the 8.37 4.00 dropped to 2.84±1.8 points,there are significant differences(P 0.05);experiment recovery was 60% for girls,insomnia rate was 100%,indicating sleep girls thoroughly improve the efficacy of therapeutic yoga obvious.2.Affecting college girls are the main factors of sleep quality sleep environment,learning,stress,emotional instability,interpersonal relationships,worry no one to talk,economic stress,life habits,sleep quality and physical and mental health directly affect students,insomnia is often associated with emotional problems,memory reduction may be severe impairment of cognitive function,or even,behavioral disorders,yoga physical therapy is an effective method of treatment of female college students with insomnia.


However, rendering folklore characters as emissaries of obeah, the religious practice, seems to dislocate the religious practice from the colonial rendering of African barbarity only to leave it enmeshed in confines of the childlike. This aside, Braziel's discussion of Kincaid's engagement with obeah for its "insurrectional, anticolonial potential to disrupt the metaphysical paradigms and rhetorical parameters of colonialist discourse" is a convincing one (55). The difficulty that comes when reviewing a text that focuses on a writer whose voice is as powerful and as distinctive as Jamaica Kincaid's is that it is easy to slip into an engagement with Kincaid's writing rather than with the critic's engagement with this literary giant. Caribbean Genesis, however, is so lucidly written, well argued, and theoretically grounded that Braziel shines.


Compaction is one of the preliminary stage of testing. The sample preparation is one of the effective measure in the outcome of the tests. Two methods of compaction (i.e standard and modified) were used in sample preparation. The mixture of soil was bentonite and different fiber percentages. The fiber dosage varied as 5%, 10% and 15%.The results showed that with increasing in compactive effort the UCS values increased.


A radical coupling reaction of diverse vinyl sulfones and epoxides was mediated by Cp2TiCl (Cp = cyclopentadienyl) to provide a straightforward synthetic pathway to hydroxy sulfones. The reaction was successfully achieved by using either an excess or a catalytic amount of the TiIII reagent. The scope of the reaction was studied for several different functionalized and substituted epoxides and vinyl sulfones.


This article will describe how transportation agencies around the world sometimes revert to the installation of Adaptive Traffic Control Systems (ATCS) in order to resolve issues with network-wide traffic signal control. But, because of time pressure, the buyers often have little time to consider the strengths and weaknesses of all system. This often impairs effective decision-making in selecting the future ATCS and can lead to increased costs, lack of evident benefits, and even a shutdown of the system. In order to facilitate the effective decision-making of transportation agencies, this article focuses on providing compiled world-wide overview, comparison and analysis of ATCS features. The large-scale comparative analysis is bringing in different perspectives and experiences with ATCS installations. Potential lessons, coming from merged experiences from around the world, are relevant to applications in European transportation agencies.


This essay approaches The Dutch Courtesan from the perspective of a cultural equivalency that John Marston posits between prostitutes and translations: both are "common" and "adulterated." Marston draws here upon John Florio's prefatory remarks to Montaigne's Essayes, and he also relies heavily on Montaigne's account of "custome." I argue that this extended appropriation entails shifts in our understanding of the play's moral dynamics, particularly regarding Freevill. Just as Marston effaces his indebtedness to Montaigne, Freevill denies dependence upon Franceschina as he rises to a position of moral eminence. But in multiple ways, The Dutch Courtesan nonetheless exposes Freevill's fantasy of unfettered self-determination.


Endotoxin extracted from the heptose-less mutant of Salmonella typhimurium was hydrolyzed in 0.1 N HCl in methanol/water (l:l, v/v) at 100 "C to yield lipid A, which was then fractionated on a Sephadex LH-20 column to yield a major monophosphoryl lipid A fraction. The monophosphoryl lipid A was further fractionated by preparative thin layer chromatography. This process yielded three major bands ("LC-1, -3, and -5) and two minor bands (TLC-7 and -9). The purity of these fractions was established by ion exchange and reverse phase high performance liquid chromatography. The thin layer fractions were analyzed by fast atom bombardment mass spectrometry. TLC-1 and -3 gave molecular ions (M-H)at m / e 1730 and 1716, respectively. Both of these fractions contained P-hydroxymyristic, lauric, and 3-myristoxymyristic acids in 0acyl linkages. The molecular formula and M, of TLC-1 are CgSH179022N2P and 1731.16; those of  TLC-3 are Cg4H1T7022NZP and 1717.15. "LC-1 was a methyl homolog of  TLC-3. The major component of  TLC-5 (CsoHlslO22NzP and M, = 1506.99) gave a molecular ion at m/e 1506 and contained two 8-hydroxymyristic acids and a lauric acid in the 0-acyl linkages. The major component of TLC-7 (CsaH126019N2P and M, = 1280.83) and the single component of TLC-9 gave molecular ions at m/e 1280 and 1098, respectively. "LC-7 contained lauric and 8-hydroxymyristic acids in the 0-acyl linkages. TLC-9 ( C S ~ H ~ O ~ O ~ ~ N Z P and M, = 1098.69) contained a single 0-acylated 8-hydroxymyristate group. TLC-1 and -3 were nontoxic in the chick embryo lethality test and regressed established tumors in the syngeneic guinea pigs.


- Oncidiinae is one of the most important subtribe among the Neotropical orchids, with an enormous diversity of floral morphology and secretory structures. This subtribe attracts a diverse array of pollinators which explore a variety of floral resources on its flowers. - In this paper we provide a detailed investigation of the floral anatomy of 32 species of micro Oncidiinae. We applied histochemical tests to all the studied species in order to determine the diversity of the glands and rewards. The diversity of secretory flower structures and rewards was related to the group of pollinators known for this orchid subtribe. - We verified that half of the species (16 species, 50%) secrete oil as a resource, being pollinated by female of solitary bees. Species of some distinct nectar secreting genera (four species, 12.5%) are pollinated by a range of nectar searching animals. Species of the genus Notylia (four species, 12.5%) release floral perfumes that reward male Euglossini bees. Most of the investigated species (six species, 18.75%) possess osmophores that are involved in pollinator attraction. Two species of Capanemia (6.25%) do not offer any floral reward, suggesting that pollination by food deception is involved. - There are strong variations in the anatomy of reward-producing structures and resources in Oncidiinae. The diversity of floral rewards affects the range of pollinators, which are related to the diversification of this subtribe throughout the Neotropics. The understanding of the relationships between Oncidiinae species and their pollinators is crucial to our knowledge of the evolution of pollination systems in the huge plant family represented by the orchids.


This article is dedicated to the one of the urgent problems of speech therapy. The main problem is the specificity of speech development in children with autism spectrum personality traits. In the first part of the article the author introduces readers with the specification of the speech development of children with autism spectrum personality traits. Each of the three le-vels of systemic underdevelopment of speech in autism is completely described. In the second part of the article discloses a technique of examination of children with autism spectrum disorders (ASD), which help to find an individual approach to the child diagnosed with violation of the communicative function of speech. This kind of profile-based questionnaire helps a specialist to present a full picture of the speech development and accurately articulate speech therapy of the child report. The presented approach is fully consistent with the provisions of the classic speech patho-logy science, and also reflects the specificity of the diagnostic survey speech therapy.


Final technical report prepared for the East And Central Africa Programme for Agricultural Policy Analysis (ECAPAPA) of the Association for Strengthening Agricultural Research in Eastern and Central Africa (ASARECA)


Objective: A process evaluation of the Northern Territory (NT) mammography program, NT Breast Screen (NTBS), during its initial 18 months of operation.


The utility model provides a saw-front longitudinal pushing apparatus comprising a push plate and an air cylinder. A piston rod of the air cylinder is connected with the push plate; the saw-front longitudinal pushing apparatus further comprises guide rails and track wheels; the push plate is provided with the track wheels; and the track wheels are matched with the guide rails. The saw-front longitudinal pushing apparatus is simply structured with practicality and low cost; rolling friction is achieved between the track wheels and the guide rails, so friction resistance of the push plate can be reduced; and a problem of longitudinal push blocking can be reduced and messed plate triple-control rate can be lowered.


Global climate during the Mesozoic and early Cenozoic is thought to have been warmer than at present, but there is debate about winter temperatures. Paleontological data indicate mild temperatures even at high latitudes and in mid-latitude continental interiors, whereas computer simulations of continental paleoclimates produce winter temperatures closer to modern levels. Foliar physiognomy and floristic composition of 23 Eocene floras from the interior of North America and Australia indicate cold month means generally >2 °C, even where the mean annual temperature (MAT) was


In the recent paper of Sawyer-Wick, a characterization of the two-weight $L^p$ norm inequality inequality for Calder\'on-Zygmund operators on pairs of doubling measures was given, which involves three conditions: a scalar testing condition, a quadratic, or vector-valued, weak boundedness property and a quadratic, or vector-valued, Muckenhoupt condition $A_{p} ^{\ell^2, \operatorname{local}}$. In this paper we show that the quadratic weak boundedness property in Sawyer-Wick can be dispensed with, and in addition show that the remaining quadratic Muckenhoupt condition in Sawyer-Wick cannot be dispensed with. For the latter point, we show more precisely that for $p \in \left (1, \infty \right ) \setminus \left \{ 2 \right \}$, the scalar $T1$ theorem for doubling measures on $L^p$ fails for a Riesz transform in $\mathbb{R}^2$, despite holding for $p=2$: namely, we construct a pair of doubling measures $(\sigma, \omega)$ that satisfy the scalar $A_p$ condition and the scalar $L^p$-testing conditions for an individual Riesz transform $R_j$, and yet $\left ( R_j \right )_{\sigma} : L^p (\sigma) \not \to L^p (\omega)$.


The story of 'Raf the dog - a tale of mystery, money and the supernatural' is discussed. The general tendency of there being two kinds of people - one who like dog's stories and another that don't is highlighted.


Successful implementation of milling requires the selection of appropriate operating parameters. In this paper a semi-analytical modelling approach and multi-objective optimisation are used to select optimum spindle speed and axial depth. The trade-off curve of removal rate and surface location error is calculated. Some degree of robustness is achieved by calculating the surface location error as a moving average over an interval of spindle speeds. The stability boundary and a selected design are compared to experimental results. The results illustrate the need to be concerned with the robustness of the optimal designs. This is addressed in Part 2 of the paper.


The experimental study results of the inhomogeneous magnetic field influence on the volume charge formation in the near-electrode region in magnetite colloidal solution have been presented in this paper. It is shown that the charge formation mechanism in the near-electrode region depends on the electric field intensity and the magnetic field gradient. This position allows us to identify the sign of the magnetite particles charge in the colloidal solution. The experimental study showed that the magnetic fluid resistance decreases in inhomogeneous magnetic field. However, the resistance values depend on the directions of the inhomogeneous magnetic field and electric current through the cell. If the directions of the inhomogeneous magnetic and electric fields coincide the resistance of the cell with magnetic fluid is greater than if they have opposite directions. This effect more significantly appears in low concentrated magnetite magnetic fluid. The internal structure of the magnetic fluid model is connected with the magnetite particles charge formed by potentialadsorbed ions and explains this phenomenon.


Abstract Given the increasing relevance of over-the-counter (OTC) drugs to individuals' health and well-being, this study explores whether selected health variables, as well as consumers' attitudes and skepticism towards advertising in general, influence their attitudes and skepticism towards pharmaceutical advertising. It extends previous research by building on the theory of inter-attitudinal consistency, examining how three different levels of attitudes and skepticism are interrelated. A field study was conducted on three continents (727 subjects; non-student sample). Results reveal that consumer attitudes and skepticism towards advertising in general, influence attitudes and skepticism towards pharmaceutical advertising in particular, which positively impact the attitudes and skepticism towards four different ad appeal types. The study extends the theory of inter-attitudinal consistency to inter-skepticism consistency. Results further indicate that attitudes and skepticism towards advertising in general can be considered as key antecedents, but that several additional health-related factors also influence consumers' attitudes and skepticism towards pharmaceutical advertising. Moreover, attitudes and skepticism towards advertising in general, towards pharmaceutical advertising, as well as towards specific pharmaceutical ads, are negatively related. Reasons explaining these results are addressed, as are study limitations and implications for future research.


With trending competition in decision-making process, linguistic decision-making is gaining attractive attention. Previous studies on linguistic decision-making have neglected the occurring probability (relative importance) of each linguistic term which causes unreasonable ranking of objects. Further, decision-makers' (DMs) often face difficulties in providing apt preference information for evaluation. Motivated by these challenges, in this paper, we set our proposal on probabilistic linguistic preference relation (PLPR)-based decision framework. The framework consists of two phases viz., (a) missing value entry phase and (b) ranking phase. In phase (a), the missing values of PLPR are filled using a newly proposed automatic procedure and consistency of PLPR is ensured using a consistency check and repair mechanism. Following this, in phase (b), objects are ranked using newly proposed analytic hierarchy process (AHP) method under PLPR context. The practicality of the proposal is validated by using two numerical examples viz., green supplier selection problem for healthcare and the automobile industry. Finally, the strength and weakness of the proposal are discussed by comparing with similar methods.


Background
 Ruxolitinib, an oral JAK 1/JAK 2 inhibitor, has been approved for the treatment of intermediate-2 or high-risk myelofibrosis, including primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF), and post-essential thrombocythemia myelofibrosis (PET-MF) in Taiwan since 2014. This registry aimed to examine the real-world safety profile and treatment pattern of ruxolitinib in Taiwan.
 Methods
 This is an observational, multi-center, post-marketing registry study. A total of 98 patients with intermediate-2 or high-risk PMF, PPV-MF, or PET-MF and receiving ruxolitinib (73.5%) or newly initiating ruxolitinib (26.5%) per clinical judgment were enrolled and analyzed in a 2-year follow-up. The primary objective was to collect the safety profile of ruxolitinib under routine practice in Taiwan.
 Results
 This interim analysis included results of 98 patients who had received ruxolitinib treatment. The median age was 68.1 years (range, 38 -87 years), 50.0% of patients were male. Of the 98 patients, 51.0% were diagnosed with PMF, 27.1% were PET-MF, and 21.9% were PPV-MF; 70.4% were categorized as Dynamic International Prognostic Scoring System (DIPSS) intermediate-2-risk group and 28.6% were high-risk group when ruxolitinib was initiated. JAK2 mutation was identified in 77.8% of 63 patients examined, while CALR mutation was identified in 6 of the 14 (42.9%) JAK2-unmutated cases. At the time of data cut-off, 23 patients (23.2%) discontinued the study mainly due to death (9.1%), adverse events (2.0%), withdrawal of consent (2.0%), and interruption of ruxolitinib ≥ 3 months (2.0%).
 The median exposure to ruxolitinib was 14.2 months (range, 0.8 - 37.9 months) from the time of study enrollment. At baseline, 75.4% of patients receiving a starting dose of > 5 - 10 mg bid, 11.2 % receiving > 10 - 15 mg bid, 10.2% receiving 20 mg bid. The prescription appeared to be more conservative than the suggested dose. The dose of 5 - 10 mg bid was prescribed for most patients at study enrollment regardless of different platelet counts (56.5% with platelet counts > 200 × 109/L, 54.5% with platelet counts 100 - 200 × 109/L, 50.0% with platelet counts < 100 × 109/L). The median dose after 6 months was maintained at 10 mg bid.
 At the time of data cut-off, adverse events (AE) were reported in 77.6% of patients and serious AEs (SAE) observed in 35.7% of patients. The most common non-hematologic AEs (≥ 5% of patients) were infections (pneumonia [9.2%], upper respiratory tract infection [8.2%], urinary tract infection [7.1%]), pyrexia (9.2%), diarrhea (8.2%), hyperkalemia (6.1%), and cough (5.1%). The infections were mainly grade 1/2, without tuberculosis or hepatitis B reactivation reported. Consistent with findings from other ruxolitinib studies, the most common hematologic AEs were anemia (10.2%) and thrombocytopenia (10.2%). However, we observed a lower incidence of anemia and thrombocytopenia compared to other studies (42.2 - 56.3%) and no one discontinued the treatment, indicating that these AEs were tolerable and manageable. Ten patients died but none of them was related to ruxolitinib.
 Over 48 weeks, ruxolitinib provided a sustained clinical benefit (n = 59), with a significant reduction in MPN-10 total score from 21.4 to 12.0 (P < 0.001). The improvement of symptoms was particularly prominent in naïve patients (change in total score: -12.8, P < 0.001) compared to non-naïve patients (change in total score: -6.1, P = 0.023), especially in itching (-2.7 vs. -0.5, respectively), problems with concentration (-1.8 vs. -0.9, respectively), and filling up quickly when eating (-2.2 vs. -1.1, respectively). In addition, the spleen size was reduced from baseline by 10.9 % in 27 evaluable patients at Week 12 and 16.4% in 13 evaluable patients at Week 24.
 Conclusions
 The interim analysis demonstrated that ruxolitinib for patients with intermediate-2 or high-risk myelofibrosis, was well-tolerated in the real-world setting in Taiwan. With a lower starting dose, the incidence of hematological AEs and infection rate appeared to be lower than previous reports. The safety profile was consistent with published data, with neither new safety signal, tuberculosis, nor hepatitis B reactivation detected. Ruxolitinib also provided continuous symptom improvement; however, spleen size reduction, an important goal of ruxolitinib therapy of myelofibrosis, was relatively modest, highlighting the need for dose optimization.

 Hou: Celgene: Research Funding; Abbvie, Astellas, BMS, Celgene, Chugai, Daiichi Sankyo, IQVIA, Johnson & Johnson, Kirin, Merck Sharp & Dohme, Novartis, Pfizer, PharmaEssential, Roche, Takeda: Honoraria. Chen:Novartis: Employment. Lee:Novartis: Employment. Ku:Novartis: Employment.


With the gradual increase of the penetration rate of distributed power generation and the deepening of power terminal sinking, the control and information transmission of distribution network become more complex. The "self-healing" of the distribution network puts forward more stringent requirements on the delay, security, reliability and other aspects of the communication system. 5G network has the advantages of ultra-high bandwidth, ultra-low latency, and ultra-large connection. These features effectively match the communication requirements of distribution network automation under the construction of new power system. This paper introduces 5G short slice technology. The self-healing distribution network automation communication scheme integrating 5G short slice communication private network is proposed. The communication structure is designed. The advantages and characteristics of the scheme are analyzed. Taking the self-healing distribution network automation transformation integrating 5G short slice technology in a domestic power grid as an example, this paper introduces its networking scheme, which provides a valuable reference path for the distribution network to realize real "self-healing" under the construction of new power system.


Electrical properties have been evaluated for polysilicon films from temperature dependence of the field-effect mobility. Density of the defect states at the grain boundary (GB) could be calculated as a function of energy for vacuum-, molecular-hydrogen- and atomic-hydrogen-annealed films. Defect states were distributed strongly near 0.14 eV below the conduction band and decreased steeply with more closer to the mid-gap. The GB was found to have no serious effect on electron and hole transport characteristics after hydrogenation.


The purpose of the paper is to identify trends in the development of the educational environment in the near and distant future in the context of globalization and define opportunities for the adoption and interpretation of these activities within the framework of the education system of Ukraine. This study used the results of generalization of literature in the fields of modern global educational trends, practical experience of the European and international community within the cooperation of universities and businesses, experience of the researchers with respect to the stationarity of the Ukrainian model of higher education and possible obstacles in the course of its reforming. Peculiarities of educational environment in the context of global changes have been considered and main trends in this field have been highlighted. The obstacles faced by the educational system of Ukraine have been identified. The need to use the European experience to ensure the interaction between universities and business has been justified. This article presents the issues related to consideration of the educational environment: the global trends, state of the labor market, constraints of the educational system of Ukraine. The study showed that the use of the European experience will enable adapting the educational space of Ukraine to the requirements of the global labour market. This paper provides an original analysis of prerequisites for development of the modern educational sphere. It will be valuable to everyone with an interest in current and prospective trends in the educational space of Ukraine.


The Anderson localization of light at the interface separating square and hexagonal photonic lattices is demonstrated numerically. The influence of varying lattice intensities and disorder level on the transverse localization of light is discussed. Both suppression and enhancement of light localization in the presence of the interface, depending on the difference in the lattice intensity in both regions, and the position of the excited lattice site are demonstrated. Such localization is compared to the cases with no interfaces. Also, it is analysed how the presence of a phase-slip defect modifies the phenomenon of Anderson localization of light at the interface.


Lizards exhibit a variety of anti-predator strategies, but the most commonly used is escape. In the case of the lizard genus Teius they use mimesis with vegetation as a first strategy and escape as the second tactic. These lizards are fast runners and can run even using only the hind legs. Here we present data on the escape behaviour on Teius oculatus and Teius teyou in different environments. A total of 30 days of field work were carried out in different areas of Paraguay during 2013 and 2014. We analysed a total of 103 records of Teius teyou and 35 of T. oculatus. All individuals of T. oculatus kept a close distance to vegetation/shelters, while T. teyou were more exposed to sight. Differences in foraging distances from the shelters between T. teyou and T. oculatus are statistically significant (K=0.2952, p=0.9609). Approach distance was similar between these two species (U=1687.5, Z=5.28, p≤0.01), but usually T. oculatus allowed a closer approach distance. After the first sprint (once a lizard was detected) T. oculatus almost always remained under the vegetation, while T. teyou showed more diverse patterns of behaviour; there was a significant difference between the species (χ2=51.069, df=3, p˂0.0001). These are the first records of escape behaviour in lizards of the genus Teius. Knowledge of behaviour and habitat use can help addressing conservation actions in places with anthropogenic alterations. In this case, T. teyou is a species adapted to forage near human dwellings and can be even present in gardens. On the other hand, T. oculatus seems to be shyer, but is able to inhabit small vegetation patches. Despite being two species living close to humans, the preservation of different kinds of shelters may be required to maintain the suitability of the habitat.


The fundamental power of microarrays lies in the ability to conduct parallel surveys of gene expression patterns for tens of thousands of genes across a wide range of cellular responses, phenotypes and conditions. Thus microarray data contain an overwhelming number of genes relative to the number of samples, presenting challenges for meaningful pattern discovery. This paper provides a comparative study of gene selection methods for multi-class classification of microarray data. We compare several feature ranking techniques, including new variants of correlation coefficients, and Support Vector Machine (SVM) method based on Recursive Feature Elimination (RFE). The results show that feature selection methods improve SVM classification accuracy in different kernel settings. The performance of feature selection techniques is problem-dependent. SVM-RFE shows an excellent performance in general, but often gives lower accuracy than correlation coefficients in low dimensions.


Within the research project "Deeveloping skills in writing and FL2 and FLE in university context through ICT", reflections on the importance  of technology in this process are presented.It focuses in particular the development of writing skills in French as a foreign language and the use of ICT in its various forms.


In this study, we have prepared a novel superhydrophilic fabric that has underwater directional oil transport capability. The fabric was prepared using a two-step process consisting of dip-coating of a crosslinkable polymer, which comprises both oleophilic and hydrophilic groups, onto fabric substrate and single side UV irradiation of the coated fabric. The fabric had in air superhydrophilicity on the two side, and it can be wetted easily once immersed in water. The treated fabric showed underwater oleophobicity on the UV-exposed surface, whereas the unexposed back side still maintained underwater oleophilicity. At the optimized condition, the fabric in water transports oil automatically from the UV-exposed to the unexposed back side, but stops oil transport in the opposite direction. Such a directional oil transport takes place without the need for oil pre-wetting or formation of plastron layer on fabric. UV irradiation time showed an effect on oil transport ability. We further showed that the underwater directional oil transport fabric had a novel "oil trapping" ability. When used to seal a container, the fabric can trap oil into the container, and once trapped the oil was kept without releasing. This underwater directional oil transport fabric may be useful for development of high efficiency oil recovery systems.


Social technologies can assist in promoting and enhancing access to our music collections. This includes rating items, writing reviews, tagging, and interacting online with music experts at the library. This new software allows for a level of discovery and exploration that has, up until now, been difficult to achieve. An exploration of how some of these technologies work and how to decide what's best for your library is discussed in this article, alaong with the examination of next generation catalogues and how the promotion and use of user-generated information is shaping our collections and inviting community sharing and jdiscovery. This article will discuss the impact user-generated information has on our music collections and examples of jhow libraries can use social cataloguers to combine local collections with local events-all in one place.


The recently published Heart Outcomes Prevention Evaluation (HOPE) study,1,2 as well as the Study to Evaluate Carotid Ultrasound Changes in Patients Treated With Ramipril and Vitamin E (SECURE),3 demonstrated that treatment with an ACE inhibitor but not vitamin E had beneficial effects on the prognosis and progression of atherosclerosis. In these studies, long-term ACE inhibition significantly reduced the rate of death, myocardial infarction, and stroke and reduced the intima-to-media ratio of carotid arteries in patients at high risk for cardiovascular events. It is likely that these findings will have wide-ranging implications for the treatment of cardiovascular disease, and the contrasting results with respect to ACE inhibitors and vitamin E provide an opportunity to revisit the role of oxidative stress in vascular disease.

### LDL Oxidation and Cardiovascular Disease

A surprising finding of these studies was the ineffectiveness of vitamin E in preventing the clinical manifestations of coronary artery disease and the progression of atherosclerosis. A wealth of previous experimental and epidemiological data suggested that excess LDL oxidation was, in part, responsible for the development of atherosclerosis.4 Because vitamin E can inhibit LDL oxidation ex vivo, a logical strategy to reduce oxidative stress would include the administration of antioxidants such as vitamin E. This approach carries considerable risk if the antioxidant is not active against all oxidants relevant to atherosclerosis. Although vitamin E effectively scavenges lipid peroxyl radicals, it has limited activity against other oxidants such as superoxide, peroxynitrite, and hypochlorous acid that have been implicated in atherosclerosis. Another risk with an antioxidant strategy relates to putative cellular compartments or "microdomains" in the vascular wall that do not contain appreciable amounts of the antioxidant. The sum total of these effects would be continued oxidation even in the presence of the antioxidant. Experimental evidence from both animals and patients suggests that lipid peroxidation does proceed …


Organisations are under constant pressure from governments and industry to implement risk management methods. There are various information security risk management methods available that organisations can implement, and each has different approaches to identifying, measuring, controlling and monitoring the information security risks. Organisations find it difficult to select an information security risk management method; therefore there is a need for an objective comparative framework to evaluate information security risk management methods. This article provides a comparative framework based on CobiT's Planning and Organisation Control Nine, Assess Risks, which can be used as evaluation criteria for information security risk management methods. Three prominent methods are evaluated using this comparative framework. The evaluated methods' strengths and weaknesses as identified through the comparative framework are highlighted. This comparative framework provides an objective evaluation method to determine whether or not an information security risk management method is in line with information technology governance.


Mass media nowadays are considered to be influential in shaping one's mind and way of life. This study was conducted essentially to determine the relationship between the respondents' exposure to mass media and their knowledge and attitude towards disaster preparedness. The researchers used the quantitative and qualitative research method. A total of 82 purposively selected residents of Barangay Makiling were surveyed. Data gathered were analyzed using frequency and percentage and weighted mean. Pearson chi-square was used to determine the relationship among the variables. Meanwhile, a focus group discussion was conducted among the eight respondents to further verify the data gathered. Based on the findings of the study, the respondents were light users of mass media such as radio, newspaper and Internet. Meanwhile, television was identified as the mostused medium.Results also showed that the respondents are knowledgeable on disaster preparedness. Most of them belong to the high and average category based on the scores they got from the knowledge test. Radio and Internet were the primary sources of information of the respondents. Findings also showed that respondents have a positive attitude towards disaster preparedness since most of their answers ranged from strongly agree to agree. Internet was revealed as the most influential medium to the attitude of the respondents. Therefore, there is a relationship between exposure to mass media and knowledge on disaster preparedness and attitude on it and Internet is the most influential mass media among the other media mentioned. The reseachers recommended to the residents of Barangay Makiling not just to expose themselves to mass media but also absorb those information presented.


SUMMARY: The association between ABO incompatibility, anemia and high levels of serum bilirubin, is well known in newborns. The present study is a prospectiv...


In the presence of the chlorate ion, the electrode reaction of the various titanium(IV)-chelates is followed by a cyclic process, i.e., an electrochemical reduction of electroactive species generated continuously by coupled chemical oxidation. The reaction rate constant of the regeneration is determined from the ratio of the limiting current observed by the DC polarographic method in the presence of the chlorate ion to that determined without it, and it is calculated using Koutecky's equation. The complex-forming agent decreases the wave height of the catalytic waves of titanium(IV) chelates, and a clear dependency of the height of the catalytic waves on the dissociation constants of the titanium chelates is found. The catalytic wave heights of the titanium(IV) chelates decrease in the order of oxalic acid, NTA, EDTA-OH, EDTA, and CyDTA; the dependency on the stability seems to be the reverse. The logarithm of the dissociation constant is in a linear relation with the logarithm of the catalytic current. T...