A 48-year-old male who had recurrent atrial arrhythmia following catheter ablation of atrial fibrillation (AF) was hospitalized in our hospital. The pulmonary veins (PVs) had been individually isolated from the left atrium (LA) at their ostium by using a 4 mm extra-irrigated ablation catheter (EZ Steer Thermocool NAV, Biosense Webster, Diamond Bar, CA, USA). The elimination of dormant PV conduction, which was induced by the rapid injection of adenosine triphosphate, had been performed following the isolation of PVs. At 5 months after the ablation procedure, the patient suffered from frequent episodes of palpitation. The surface 12-lead electrocardiogram (ECG) during palpitation demonstrated frequent premature atrial contractions (PACs) followed by a nonsustained AF. An electrophysiological study and catheter ablation to treat the recurrent atrial arrhythmia were conducted after the patient provided his informed consent. A steerable 16-polar 2 site (6-polar for right atrium and 10-polar for coronary sinus) mapping catheter (InquiryTM Luma-CathTM, St. Jude Medical, St. Paul, MN, USA) was inserted into the coronary sinus positioned at 4–5 o'clock along the mitral annulus in the left anterior oblique projection via the right subclavian vein. The LA and PVs were explored through transseptal catheterization with 2 long sheaths. The reconnection between the PV and LA was evaluated by using circular mapping catheters (Lasso, Biosense Webster). A 4 mm extra-irrigated ablation catheter was used for mapping and ablation (EZ Steer Thermocool NAV, Biosense Webster). The surface electrocardiogram and bipolar endocardial electrograms were continuously monitored and recorded for off-line analysis (Bard Electrophysiology, Lowell, MA, USA). In the left superior PV (LSPV), the rapid regular PV activities were recorded by a circular catheter during sinus rhythm with frequent PACs (Fig. 1). The ablation catheter (for mapping) was inserted at


Job Characteristics, Work-Life Balance, the Five-Factor Model of Personality and Organizational Commitment of Operation Workers at A Vessel Glass Company


Hilgardite*4M occurs as euhedral crystals in the Salt Springs and Penobsquis evaporite deposits of New Brunswick. It is monocligric, space group Aa, a 11.470(3), b ll.32l(4), c 6.321(5) A, I : fr .U2 Q)n . The mineral is biaxial (+), a 1.623Q). p r.628(2), t l.6s6Q\. 2V (meas.) 34Q)",2V(calc.)Mo,Y = b, Ztrc = l" (intheacuteanCle 0). The measured and calculated densities are 2.67(3) and 2.676Q) g/cm3, respectively. The crystals from New Brunswick are more complex morphologically than the type material from Louisiana, andthe following forms havebeen identi f ied: {010}, {100}, {160}, { l_40}, { l l0}, {01U, { l l l } , {322}, l2r rl, l23r), 1s221, 13 r rl, ls22}, 1231\, 13221, { I 3 1 }, { 122} and {3?21. Electron-microprobe analyses of thee crystals showed no cations other than Ca and minor Sr. Some Sr-rich, platy crystals with values of Ca,/(Ca+ Sr) as low as 0.55 were also analyzed, but this material appears to be a triclinic polymorph of hilgardrte4M. The most Carich sample gave the following analytical datai CaO 32.1, SrO 0.3, Cl 10.2, B2O3(52.4), H2O (5.4), sum-1@.4, less O=Cl 2.3, total 98.1 wt,qo (with B2O3 and water calculated to conform to the ideal formula, Cap5OeCl.H2O), TGA and evolved gas analysis of New Bruisfoik ma6rial gave 5.9 wt.qo water and 17,4 wt9o (FICI + other volatiles). Very similar results were obtained from the Louisiana material. The HCI probably is derived from the contents of channels in the zeolitic structure.


The hydraulic system on a machine drill jombo under normal circumstances, there is movement of the hydraulic boom systems that balance the movement of the cylinder tiil left cylinder / boom cylinder to remain parallel but the movement does not balance. This was attributable to the difference in speed between the left cylinder / tiil boom cylinder on the cylinder due to differences in speed due to changing the oil viscosity and fluid pressure in the flow is not constant.


Swimming of microorganisms is further developed from a viewpoint of strings and membranes swimming in the incompressible fluid of low Reynolds number. In our previous paper the flagellated motion was analyzed in two dimensional fluid, by using the method developed in the ciliated motion with the Joukowski transformation. This method is further refined by incorporating the inertia term of fluid as the perturbation. Understanding of the algebra controlling the deformation of microorganisms in the fluid is further developed, obtaining the central extension of the algebra with the help of the recent progress on the $W_{1+\infty}$ algebra. Our previous suggestion on the usefulness of the $N$-point string- and membrane-like amplitudes for studying the collective swimming motion of $N-1$ microorganisms is also examined.


The flrst part of this article deals with the computational analysis of the temperature rise of encased conductors of a nuclear power plant in the steady state. The generated heat is due to electric losses in difierent modes of loading. In the second part of this article the results of these computations (by analytical and flnite element method) are compared with the results of an experiment performed on a one-phase model of an encased conductor. The obtained results are useful in assessing the safety of operation of conductors in the operating mode and of the possible critical states of the power plant. K e y w o r d s: encased conductor, temperature rise, nuclear power plant, computation and experiment


The dramatic increase in the volume of commodity logistics information presents a challenge to a limited number of communication systems. Based on the information value as a quantitative standard, direct insertion method and multi-stage transmission buffer method are used to send the priority order of the logistics message. The message priority distribution aided decisionmaking program is designed to ensure the real-time value of message distribution. It provides new ideas and methods to improve the efficiency of logistics information and communication system.


The competitiveness of an industry, a region, and a nation is directly related to its innovation capacity which is resulting from an effective innovation system. National innovation system will only be effective if there is a good interaction and interdependency among industries, research institutions, education institution, and other supporting bodies such as financial institution, infrastructure, regulation etc. Former studies reveal that the innovation system in Indonesia has not functioned effectively [1]. In the absence of effective national innovation system, the regional government can take serious attempts to develop and strengthen its regional innovation system in order to enhance its regional competitiveness, especially in the era of regional autonomy. This paper is based on a research conducted by Center for Innovation LIPI in 2004. It briefly highlights some theoretical frameworks on regional innovation system especially in the food industry cluster and reviews the characteristics of food industry in West Java and Lampung Provinces using Michael Porter's diamond model. The study reveals that there is a weak linkage amongst the elements of regional innovation system in the food industry, though the local government has made significant attempts to strengthen and improve the condition. However, it is identified that industry within the cluster has enjoyed some benefits though this is limited to trading efficiency (trade network) mostly due to geographical proximity; while knowledge spill over (knowledge network), the very core of the innovation system, within the cluster is still very insignificant. Finally it proposes some recommendation especially on the utilization of the existing supporting local actors to act as local facilitator especially to bridge the information gap amongst the elements of the innovation system.


The liquid flow in blast furnace hearth can result in the erosion of hearth. To prolong the campaign life of blast furnace, the effects of coke bed structure, coke porosity and deepness of taphole on liquid flow in hearth were studied by κ-e model under different conditions. The results show that with the decrease of coke porosity, the peripheral flow is enhanced. Moreover, the existence of narrow coke free zone and the deepness reduction of taphole can increase the flowability on the bottom of hearth.


Every few generations an individual rises who, by his insight, brilliance, and perseverance, leaves an enduring stamp on a field of endeavor and who sets the direction of the discipline for years to come. Such a person was John George Paxton Cleland MD, CM, MSc, FACS, FRSM. John Cleland was born in Sandon, British Columbia, in 1898. Sandon was a small mining town to which his father, a Presbyterian missionary, had been posted. John Cleland grew up in Penticton, BC. At the outbreak of the First World War he volunteered for active service but was under age. He did reach France at the age of 16, however, playing cornet with the Canadian Army Medical Corps band, and served 3 years as a stretcher-bearer. He then joined the Royal Naval Air Service, and trained as a fighter scout pilot with the 86th squadron, surviving three crashes during training. He was told on joining that life expectancy at the front was 12 days, and later volunteered to test a new parachute. It is fortunate that the war ended and the parachute drop was cancelled by a cable from London that read: 'Owing to cessation of hostilities, all human droppings are herewith suspended.' After the war, Cleland undertook what we would consider both pre-medical and medical course work, and emerged from McGill University with a medical degree in 1924. In the ensuing three years, he was a Fellow in Surgery with Sir Henry Gray, and a Fellow in Obstetrics and Gynecology with Dr Walter Chipman. Subsequently, while engaged in experimental physiology research with Dr John Tait, he devised a method for determining the afferent nerve supply of the spleen using 'visceromotor' reflexes. 1


Different countries have different customs and traditions, resulting in great differences between the cultures. It's important to know the differences which are a barrier in English teaching,


In order to solve the problem of the key variables prediction and the profit function prediction for fed-batch fermentation,this system is designed using VC++ programming language technology and rolling learning-prediction based on neural networks.It is put into trial run in an antibiotics plant,and results show the system runs steadily with high prediction accuracy and satisfactory effect.


The double seals technology is widely used in the large oil tank. But several oil tank lightning fire accident investigations illustrate that fires were caused by the discharge in the double sealing space. In this paper, the mechanism of lightning fire accident in the double sealing space was analyzed based on the investigation results of some domestic lightning accidents of large floating roof tanks. The lightning protection measures for floating roof tank's second sealing space was summarized including both domestic and foreign lightning protection related codes, specification specifications and technology technologies.


In the present study, effect of a parameter for increasing the reaction furnace temperature and sulfur recovery of Claus sulfur recovery units (SRUs) is investigated by TSWEET process simulator based on Gibbs free minimization. The effect of oxygen enrichment on the reaction furnace temperature and sulfur recovery has been studied by proposed simulator. In the case of the effect of O2 concentration, temperature of main burner increased monotonically. It is found that sulfur recovery (in the O2 high concentrations) increases up to a maximum value and then decreases with increase of O2 concentration, while this is not the case for O2 low concentrations.


Many pre-stack depth migration (PSDM) methods have been developed and widely utilized to generate depth domain seismic images, resulting in a need for depth domain pre-stack seismic inversion of the subsurface elastic properties for reservoir characterization. Time domain inversion techniques are often used after the depth domain dataset is transformed to the time domain. We provide a new technique for directly inverting depth domain pre-stack seismic data for subsurface elastic properties: P-impedance (Ip), S-impedance (Is), and density (?) in the depth domain. The proposed depth domain work ow eliminates the need for time-depth/depth-time conversion, making it both efficient and effective. Using a depth-wavenumber decomposition approach, the suggested work flow fi rst extracts a collection of depth and angle varying wavelets to handle the potential nonstationarity of the depth domain pre-stack seismic data. The extracted depth and angle variant wavelets were used in a basis pursuit inversion, which enhanced the resolution of the inversion results. The work flow was tested on the Wenan three-dimensional field dataset, demonstrating its viability for practical applications.


Abstract: emergence of world wide web has completely globalized the whole world into a global village business, entertainment, education, teaching, learning every field has achieved new dimensions and plays important role in the development of nation.one of the outcome of this is e learning. E-Learning is the extended form of traditional classroom teaching. The paper highlights concept, tools and initiatives taken by several and institutions and Library centers around the world and in India.


This paper introduces an evolutionary optimization procedure for the design of permanent-magnet motors (PMMs) for electric vehicle (EV) applications, considering a specific drive cycle with multiple operating points. For the purposes of the analysis, the New European Drive Cycle (NEDC) has been employed with two alternative PMM configurations. Energy distribution over the NEDC for a small passenger's EV has been calculated and the equivalent multiple operating points have been extracted, using appropriate weights, in order to maintain an equal energy consumption basis, resulting in reduced computational cost. The proposed optimization technique is constituted of an adaptive differential evolution (DE) algorithm involving dynamic variation of the mutation factor, combined with finite-element (FE) and circuit models. The procedure is based on the precise calculation of the two axes input current components for each candidate solution and operating condition. The methodology introduced presents stable and fast convergence characteristics and has been applied to optimize the geometry of both surface-mounted and interior PMM configurations. The proposed motor is based on the thorough tradeoff among the two alternative optimized geometries and has been validated through measurements on a prototype.


In the light working practice,this paper explores the nature and basic features of information-based surveying and mapping supporting system,demonstrates the four kinds of information consciousness needed to be strengthened in the process of the construction of information-based surveying and mapping supporting system and the four key issue needed to be dealt with.


1.-THE THEME . I SPEAK of a few points in brain architecture, as manifest in the conformation and relations of folds and fissures of the brain cortex; and they are taken in reference to mental states, and particularly to the stigmata of hereditary mental degeneracy. Though long pursued, my studies on this subject have been irregular and intermittent, partly because, at necropsies, attention was more potently occupied with the pathological and histological conditions of the brain and of the whole frame; and partly because other worked pressed, and the IimitWations of time were rigid. The accepted standards of gyral conformation having been meditated on at first, my subsequent studies on the subject were largely independent of the results of other observers; and thus the mind was purposely kept free from prejudice and preconception. For this abstention there were two reasons: First, one's dissatisfaction with some details of the then-accepted standards of convolutional form (to this subject I will recur); and, secondly, and later on, the appearance of a certain doctrine on the brain in relation to criminal anthropology, involving a special ascription of particular deviations from type as being distinctive of criminals; a doctrine which. at the time, appeared to be incorrect as gauged by what I had seen in brains of the insane; a doctrine which has been partially or fully abandoned, since then, by those or most of those who held it in that sense, or were inclined to do so.


The authors discuss the results of a study in which they investigated 68 university-level media education students' knowledge of Web 2.0 and their conceptions about its impact on media literacy. The main research finding was that the students argued firmly in favor of new media literacy. Their own use of Web 2.0 applications was, however, rather passive in the sense that they did not really utilize the potential that Web 2.0 provided. The new volitional media literacy that emerged from the study includes such categories as: willingness, collective activities, authority of knowledge, users as producers, checking the reliability of knowledge, and teaching media literacy.


Disclosed is a method and an apparatus for allocating a time slot in a time-division duplex system. The method includes the steps of: detecting a first Mobile Station (MS) located in an adjacent area between a first cell and a second cell adjacent to the first cell among MSs located in the first cell formed by a first Base Station (BS); detecting a second MS located in an adjacent area neighboring to the first cell among MSs located in the second cell; finding an MS located in the farthest position from a second BS forming the second cell among the MSs located in the first cell; and allocating a first time slot corresponding to a second time slot allocated to the second MS to the MS located in the farthest position from the second BS.


In this study, we analyzed the efficiency changes of the Turkish banking sector between the years 2005-2014, when the global financial crisis was experienced. Data Envelopment Analysis (DEA) methodology was applied to obtain efficiency scores. Then, panel regression analysis was performed to explore the main determinants of efficiency changes. The findings have shown that internal factors are more effective than external ones on banks efficiency. The financial crisis was found to have a slight impact on banks' efficiency in managing their financial resources. GDP and inflation had negative relationship with bank efficiency due to the unanticipated inflation rate and volatile economic growth. The empirical findings imply that more efficient banks generate higher returns accordingly.


Joseph Boyden. Through Black Spruce. Toronto: Viking Canada, 2008. 360 pp. $34.00 hc. Through Black Spruce, Joseph Boyden's intense second novel, won Canada's prestigious Giller Prize in 2008, and deservedly so. Boyden, originally from Northern Ontario, now divides his time between there and Louisiana, where he teaches in the MFA program at the University of New Orleans. Through Black Spruce centres on the Cree community around Moosonee, examining the effects of the historical and present-day colonial violence that is enacted both by institutions and individuals. Structurally, the novel alternates between the narratives of two protagonists: Will Bird, an aging ex-bush pilot who is in an unexplained, trauma-induced coma at the novel's opening; and his adult niece, Annie, who experiences both seizures and visions, and who is troubled by the disappearance of her sister, Suzanne. The narratives unfold in flashbacks, as the unconscious Will "tells" his story to his nieces, while Annie, believing that hearing her voice will help her uncle to recover, brings him up to date on her search for Suzanne. Their narratives are linked through the violent and terrifying presence of motorcycle gangs, whose drug-dealing influence reaches even--or perhaps especially-- into remote communities. Together, the narratives combine to provide a composite portrait of how particular events can have far-reaching and unpredictable effects; the reader is in the unique position of understanding how actions in one person's story can affect those in the other's. While a few of Boyden's critiques are too heavy-handed--Annie's status in the New York modeling community could be explained far more subtly than through the repetition of her "Indian Princess" nickname--the world that he creates is persuasive in its depiction of the relation between past and present, and what it can mean to be Aboriginal in an increasingly globalized world. Colonization is still ongoing; it just wears new disguises. The economic exploitation originally practiced by the Hudson's Bay Company, and still evident in the low price offered when Annie goes to sell her furs at the Northern Store (174-75), is here supplemented by the underground drug economy of motorcycle gangs. When one enforcer refers to the gang as "the Corporation" (336), the economic connections are clear. As traditional cultural practices diminish, new dependencies grow, whether on drugs or on the new "Anishnabe soul food" (36): KFC. These new structures take a place alongside more obviously oppressive institutions, like the residential school that, Will sadly remarks, shattered his relationship with his father (80-82). …


Many school educators, instructional designers, and corporate training specialists believe that learning styles are important and that much of training success relies on the craft of incorporating learning styles into learning materials. But how do common views and popular wisdom on learning styles align with what the psychological sciences tell us today? Does matching instructional design to learning styles really result in learning enhancement? This article seeks to examine such questions based on current research in psychological sciences.


Prophyllactic HPV vaccines are efficacious in preventing persistent infections by vaccine-HPV types and re- lated cervical disease. The maximum effect is achieved in women who are not exposed to HPV vaccine types at the time of vaccination (HPV DNA negative women). Today's published data demonstrate equal clinical vaccine efficacy in women between 15 and 26 years and women between 24 and 45 years. The public health effect of vaccinating women older than 25 years is not clear yet, but may be smaller than after vaccination of adolescents. Unresolved issues are dura- tion of protection and long-term preventive effects after treatment of HPV-related disease or natural clearance of HPV in- fection. Furthermore, it remains difficult to define subgroups of older women who would benefit from the vaccine. It may be that older women exposed to HPV or who are being treated for HPV related disease will benefit most at long term. This needs longer follow-up of vaccinated women and more detailed analysis of data from vaccine trials. © 2010 Bentham Science Publishers Ltd.


Cellular shear adhesion, which is the adhesion between cells and the substrates, plays an important role in cell activities. This article aimed to develop a robotic system with automated cell aspiration and in situ micropipette cleaning for shear adhesion force measurement. We proposed a shear adhesion force measurement method based on the balance pressure model and designed a cell placement device with a double-Petri dish to improve the accuracy and efficiency of the measurement. Then we achieved the whole measurement automation by cell selection based on image texture analysis, contact detection based on motion history image (MHI) analysis, and cell aspiration state detection based on sub-pixel image registration. Three types of adherent cells (pancreatic cancer cell, osteoblast, and osteoclast) were used to validate the automated measurement system. The system demonstrated an overall success rate of 75.6% with an average measurement time of 5 min. The experimental results show that pancreatic cancer cells possessed higher shear adhesion force than osteoblasts and osteoclasts. There was a significant difference in adhesion between osteoblasts and osteoclasts. Conclusion: The experimental results demonstrate that the system was an efficient, reproducible approach for shear adhesion force measurement automatically. The robotic system eliminated the stringent skill requirements of operators and improved the consistency and efficiency of the shear adhesion measurement, which can be applied to life science.


The structural, magnetic, magnetocaloric and Griffiths phase (GP) disorder of non-stoichiometric perovskite manganites La0.8−xSr0.2−yMn1+x+yO3 are reported here. Determination of valence states and structural phases evidenced that the smaller cations Mn and Mn will not occupy the A-site of a perovskite under atmospheric synthesis conditions. The same analysis also supports that the vacancy in the A-site of a perovskite induces a similar vacancy in the B-site. The La and Sr cation substitutions in the A-site with vacancy influences the magnetic phase transition temperature (TC) inversely, which is explained in terms of the electronic bandwidth change. An anomalous non-linear change of the GP has been observed in the Sr-substituted compounds. The agglomeration of Mn-Mn pairs (denoted as dimerons), into small ferromagnetic clusters, has been identified as the reason for the occurrence of the GP. A threshold limit of the dimeron formation explains the observed non-linear behaviour of the GP formation. The Sr-substituted compounds show a relatively large value of isothermal entropy change (maximum 3.27 J/kgK at μ0H = 2T) owing to its sharp magnetic transition, while the broad change of magnetization in the La-substituted compound enhances the relative cooling power (maximum 98 J/kg at μ0H = 2T).


The general structural plan and main design parameters of a corn stalk hammering and shaving machine are introduced and the machine can simplify corn straw shaving process and improve shaving efficiency.


The combination of Z‐contrast scanning transmission electron microscopy, transmission electron microscopy, and secondary ion mass spectroscopy allows the most accurate determination, to date, of the As doping profile across the polycrystalline Si/Si interface of an npn polycrystalline Si emitter bipolar transistor. We measure a peak in the As doping profile which is coincident with the polycrystalline Si/Si crystallographic interface and is approximately 40 A full width at half‐maximum. There is a uniform As dopant level in the polycrystalline Si emitter of 2×1020 cm−3 and an estimated maximum As concentration of 5×1020 cm−3 in the peak at the interface.


DNA from lambdagt-lambdaB bacteriophage was cleaved with EcoRI endonuclease and fragments from EcoRI-digested E. coli DNA were inserted. This DNA was used to infect E. coli, and phages containing the gene for DNA ligase were isolated by genetic selection. Two different hybrids were found with the same E. coli segment inserted in opposite orientations. Both hybrids produced similar levels of ligase as measured in crude extracts of infected cells.


This article provides for the methods and ways of introducing a standardization system in innovative activities, as well as its introduction, positive effects on many modern developments, performance efficiency. The importance of standardization system in innovation activities is widely covered


Objective To establish a two-dimensional electrophoresis technology on brain tissue protein of rat.Methods Lysis buffer of different volume was taken to extract brain tissue proteins of rat,and different protein quantities(1 mg,2 mg,3 mg)were taken to establish a two-dimensional electrophoresis.Coomassie brilliant blue was applied to stain protein,and patterns were analyzed.Results With a molecular mass between 6.5~200 KDa and isoelectric points(pI)from 3~10,1 mg proteins obtained 574 protein spots,2 mg 798,and 3 mg 803.Conclusion A two-dimensional electrophoresis technology on brain tissue protein of rat has been established successfully.


In June 2004 the Department of Health made a commitment to reduce waiting times from GP referral to hospital treatment to less than 18 weeks by 2008. Patients with chest pain are often now seen within two weeks thanks to the success of rapid-access chest pain clinics. Around 10-25% of these patients are referred for diagnostic coronary angiography (CAG) and of these, about 30% require percutaneous coronary intervention (PCI) to treat coronary stenoses. Conventionally, UK practice has been that such patients occupy two waiting lists: one for the CAG, which is often performed by a non-interventional cardiologist, and one for the PCI. This pathway makes achieving the 18-week target challenging. We introduced a new care pathway whereby all elective chest pain patients referred for CAG to one of the interventional cardiologists were listed for a standby coronary angiogram (SBCA), during which if PCI was indicated then it was performed immediately. We present the results of an audit of 102 consecutive patients since this pathway was introduced that demonstrates one method of achieving the 18-week target for this group of patients. This can now be further refined by aiming to achieve a higher proportion of day-case PCI cases.


In this letter, the design of power divider with negative group delay (NGD) characteristics is presented. From an analysis, the NGD associated with different transmission paths is found to be identical and obtained by loading resistor connected short-circuited coupled lines with an open-circuited isolation port. The proposed structure is validated by constructing a two-way microstrip line power divider with equal power division ratio, which is centered at 2.14 GHz. The measured results show excellent agreement with simulations and theoretically predicated results. From the measurement, the group delays and magnitudes of S-parameters between the different transmission paths are determined as -1.16 ns, -9.29 dB, -1.17 ns, and -9.30 dB. The measured input/output return losses and isolation at center frequency are higher than 28.92 dB, 26.76 dB, and 42.2 dB.


Artinian serial principal ideal rings and artinian serial rings are traditionally called uniserial rings and generalized uniserial rings, respectively. These rings are important classical artinian rings as well as quasi-Frobenius rings. The reader is referred to Faith's Book [4] for these rings. As is well known, a ring R is a quasi-Frobenius ring iff every injective R-module is projective, and if every projective R module is injective; while R is a uniserial ring iff every quasi-injective R-module is quasi-projective, and iff every quasi-projective R-module is quasi-injective ([2], [3], [5]). The purpose of this paper is to give similar characterizations of a generalized uniserial ring R in terms of extending and lifting modules. More specifically, consider the following implications:


Introduction Systemic light chain (AL) amyloidosis is a clonal plasma cell neoplasm, that carries a poor prognosis. Treatment is adapted from protocols as used in MM, and include bortezomib-based (PI) regimens with or without stem cell transplantation (SCT). PI-based regimens have improved treatment responses and outcomes. Cytogenetic analysis has become an important tool in the diagnostic process of plasma cell disorders, and evidence for prognostic significance of specific genetic abnormalities in relation to therapy efficacy is recognized in systemic AL amyloidosis. Thus far, this prognostic significance has been evaluated in single center institutions.
 Aim This nationwide, population-based study aimed to assess the impact of cytogenetic abnormalities on hematological response and survival among patients with systemic AL amyloidosis treated with PI-based regimens.
 Methods We identified 349 patients ≥18 years with systemic AL amyloidosis diagnosed between 2017 and 2019 in the Netherlands Cancer Registry, with survival follow-up until February 1, 2021. Data on therapeutic strategy was known for all individual patients. The cytogenetic aberrations studied include gain(1q), hyperdiploidy, del(17p), and IGH rearrangements, i.e. t(11;14), t(4;14), t(14;16), and t(v;14q32) (non-specified IGH rearrangement). Hematological response and overall survival (OS) were evaluated in relation to cytogenetic aberrations. OS was defined as death by any cause post-diagnosis. Uni- and multivariable analysis for establishing independent predictors of OS, i.e. age, sex, cytogenetic assessment and SCT, was performed using Cox regression. Patients diagnosed at autopsy (n=4), patients who did not start first-line therapy (n=64) or received other therapies (n=37), and patients with systemic AL amyloidosis related to Waldenström Macroglobulinemia (n=10) were excluded.
 Results In our analytic cohort, 234 patients (median age 67 years; 62% males) were treated with PI-based regimens. Of these patients, 153 (65%) were ≤70 years at diagnosis. SCT was performed in 70 (30%) patients following PI-based regimens. For 170 (73%) patients, cytogenetic assessment was performed. IGH rearrangements were observed in 76 patients (45%), comprised of t(11;14) in 27 patients, t(4;14) in 3 patients, t(14;16) in 2 patients and non-specified IGH rearrangements in 44 patients. Furthermore, 26 patients carried a gain(1q), 4 patients a del(17p), and 33 patients were hyperdiploid. Due to the limited patient number with del(17p), response and OS was not evaluated for this subgroup.
 A complete remission (CR; n=53), very good partial response (VGPR; n=66), or partial remission (PR; n=55) was accomplished for 74% of the patients, ≥VGPR for 51% of the patients. The reached hematological response was irrespective of the detected cytogenetic abnormalities. In detail, ≥VGPR was 56% for patients with a t(11;14), 62% for patients with a gain(1q), 55% for patients with hyperdiploidy, and 50% for patients with an IGH rearrangement and this was not statistical significant different from patients without these cytogenetic abnormalities.
 The 3-year OS was 61% for patients treated with PI-based regimens. For patients with a cytogenetic assessment (n=170), there was no significant difference in 3-year OS between patients with or without a t(11;14) (69% vs. 66%, respectively; p=0.70), with or without gain(1q) (57% vs. 68%, respectively; p=0.58), with or without hyperdiploidy (72% vs. 65%, respectively; p=0.63), or with or without an IGH rearrangement (59% vs. 72%; p=0.21). Only SCT was an independent predictor for reduced risk of mortality in uni- and multivariable analyses, overall as well as for the specific cytogenetic subgroups.
 Conclusion In this Dutch 'real world' population of AL amyloidosis patients treated with PI-based regimens, 74% had a ≥PR and 51% had ≥VGPR. The 3-year OS was 61%. We evaluated the cytogenetic data of 170 patients, but could not confirm a relation between PI-based regimens and outcome, overall as well as in specific cytogenetic subgroups. Patient numbers of the cytogenetic subgroups were low and we could not determine the partner gene in 44 patients with an IGH rearrangement. To the best of our knowledge, this is the first population-based study to evaluate the prognostic relevance of cytogenetic abnormalities in relation to hematological response and OS among systemic AL amyloidosis patients.

 Minnema: Alnylam: Consultancy; Kite/Gilead: Consultancy; Jansen-Cilag: Consultancy; BMS: Honoraria; Celgene: Other: Hospitality.


Neoepitopes are tumor-derived immunogenic peptides that arise from intracellular proteolytic processing of somatic mutation in protein coding genes. These peptides bind HLA Class I proteins and are presented on the surface by antigen presenting cells. Productive engagement of HLA Class I-bound peptide with T-cell receptor (TCR) activates CD8+ T-cells to generate cytotoxic T cells, which mediate lysis of the neoantigen-expressing tumor cells. Neoepitopes can be used as cancer vaccines to prime CD8 T-cells against tumor cells. As tumors accumulate hundreds of mutations during cancer development and only a small subset of these are immunogenic, identifying the neoepitopes requires accurate modeling of the steps involved in peptide production, presentation as well as TCR binding. Most current pipelines prioritize neoepitopes based on the expression of mutant proteins and their HLA binding affinity. However, presentation of peptides on the surface is not sufficient to activate T-cells. To improve the predictive power of our neoepitope prioritization pipeline and to circumvent selection biases that are inherent with using HLA binding as a proxy for neoepitope prediction, we developed a novel algorithm that prioritizes peptide interactions with the TCR. OncoPeptVAC algorithm uses features selected by analyzing crystal structures of TCR and HLA-peptide complex present in the Protein Data Bank. A neural network model was built to derive a composite score that includes, besides TCR binding, other features associated with the peptide, such as level of expression of the mutant allele, affinity of HLA binding, affinity of TAP binding and sensitivity to proteasomal processing. We validated our neural network prediction model on known immunogenic and non-immunogenic peptides and achieved superior accuracy, sensitivity and specificity of prediction compared to using the standard HLA binding affinity of ≤500 nM. By applying OncoPeptVAC neoepitope prioritization solution to 2.2 million unique somatic mutations, we identified ~700 immunogenic peptides derived from recurrent somatic mutations in all cancers. Several of these peptides were validated on a CD8 T cell-activation assay. Our in silico prioritization platform combined with the cellbased validation method is a powerful tool to identify therapeutic vaccines for personalized cancer immunotherapy applications. Citation: Majumder, S., Kode, V., Shah, P., Kumar, A., Gupta, R., Chaudhuri, A. and Chakraborty, P. OncoPeptVAC: A robust TCR binding algorithm to prioritize neoepitope using tumor mutation (DNAseq) and gene expression (RNAseq) data [Abstract]. In: Abstracts of the NGBT conference; Oct 02-04, 2017; Bhubaneswar, Odisha, India: Can J Biotech, Volume 1, Special Issue (Supplement), Page 223. https://doi.org/10.24870/cjb.2017-a208


The objective of this study was to design of an output based impedance adaptive controller for a special class of cervical orthoses, a class of biomedical devices for the rehabilitation of neck illnesses. The controller used the adaptive sliding mode theory to enforce the tracking of the reference trajectory if the patient was not resistant to the therapy. If the patient rejects the orthosis activity, a second impedance-based controller governs the orthosis movement allowing the patient to take the leading role in the orthosis sequence of movements. The proposed controller considers a weighted controller combining the tracking and the impedance controls in a single structure. The monitoring of the external force was evaluated on a novel weighting function defining on-line the role of each controller. The proposed orthosis was motivated by the prevalence of whiplash, which is a syndrome that is produced by forced hyperextension and hyperflexion of the neck. This study included the development of a technological prototype of the orthotic type to support the recovery of patients diagnosed with whiplash. The sections that make up the orthotic device are two independent systems that move the patient's head in the sagittal and frontal planes. For this purpose, the mechanical structure of the cervical orthosis was made up of 7 pieces printed in 3D with polylactic acid (PLA). The operation of the cervical orthosis was evaluated in two sections: (a) using a simulation system, which consists of a spring with an artificial head and the development of a graphic interface in Matlab, and (b) evaluating the controller on the proposed orthosis. With these elements, the follow-up of the trajectory proposed by the actuators was evaluated, as well as its performance in the face of the opposition that a patient generates. The superiority of the proposed controller was confirmed by comparing the tracking efficiency with proportional-integral-derivative and first-order sliding variants.


Aimed at the characteristics of modern enterprise manufacturing information such as multi-varieties,small-batch and high-quality,considering that the different products in the production process experienced different assembly time,it is researched for the production scheduling to reduce the total production time and cycle effectively. Based on production characteristics,heuristics production scheduling system is proposed which can effectively shorten the production adjustment time. Form the simulation results,we can see that the algorithm is able to give a more satisfactory production scheduling program,and the productivity can be improved greatly


The invention discloses a method for removing indoor air particulate matter through a wet method. The method comprises the following steps of atomization and mixing, wherein air with dust passes through water mist to form the air with dust fogdrops; dust removal and sterilization, wherein the air with the dust fogdrops is accelerated and collides a baffle with silver catalysts, and after the silver catalysts remove microorganisms in the dust fogdrops, the dust fogdrops are collected on the baffle and flow downwards under the action of gravity, and the air with the dust fogdrops forms primary dust removed air; steam-water separation, wherein steam-water separation is carried out on the primary dust removed air through a steam separator; cleaning and humidification, wherein the air after the steal-water separation is cleaned again through water mist and is discharged out. The method has the advantage of being good in air purification effect. The invention further discloses a device for removing the indoor air particulate matter through the wet method.


This chapter addresses stimulation techniques, the issue of the stimulation electrode positioning, motor unit (MU) activation order, and spinal involvement in electrically elicited contractions. Two stimulation techniques are commonly used: bipolar, and monopolar stimulation. The differences between these two methods concern the geometry and relative position of the stimulation electrodes. Surface electromyography (sEMG) signals can be detected during selective electrical stimulation of a nerve branch or of a motor point of a muscle. The resultant sEMG signal is a compound motor action potential (CMAP), also termed as M-wave. Since the M-wave represents the sum of the potentials of the concurrently activated MUs, its change is generally assumed to reflect changes either in the number or in the sarcolemmal properties of activated MUs. Neuromuscular electrical stimulation (NMES) combined with sEMG isolates the contributions of peripheral fatigue because it gives the experimenter control of MU firing frequency and recruitment.


Teachers and parents have duties and responsibilities for the good and bad of children's Islamic religious education, this will have a positive or negative impact on the development of the younger generation in the future, this is where teachers are required to carry out their obligations by providing education and helping solve problems in children so that they do not experiencing difficulties in life. The objectives of this study are: 1) To find out the efforts made by teachers in the process of instilling moral values ??in early childhood at PAUD Tunas Harapan II Cisaat. 2) To find out the moral materials taught at PAUD Tunas Harapan II Cisaat. 3) To find out the method used in Tunas Harapan II Cisaat -Ikhlas Madium Rengas, Central Lampung. This type of research is field research. The nature of the research is descriptive qualitative. This study uses data collection techniques with interviews, observation and documentation. The data analysis technique used in this study uses data reduction (data reduction), data presentation (data display), and conclusions (conclusion drawing/verification). The results of data analysis showed that: 1) PAUD Tunas Harapan II Cisaat teacher in introducing and teaching the essence of religious teachings to children so that they can know and understand them and familiarize themselves with carrying out these religious teachings. The application of inculcating moral values ??in the PAUD is carried out in accordance with special education for early childhood children by taking into account the principles of early childhood development. 2) Moral materials applied in learning to early childhood at PAUD Tunas Harapan II Cisaat include human morals with Allah SWT, human morals with oneself, human morals with fellow humans and human morals with other creatures and their natural environment. 3) The method used in instilling moral values ??to early childhood teachers of PAUD Tunas Harapan II Cisaat uses the field trip method, the conversation method, the demonstration method, the storytelling method, the singing method and the assignment method.


In this article the derivation of a general retrieval effectiveness measure is investigated. It is shown that the measure cannot be justified on the basis of formal considerations associated with measurement theory. The implications of the mathematical condition which defines the relative importance a user assigns to precision and recall are also investigated. Inconsistencies in the definition of the associated weight are resolved, and it is shown that the influence of the weight on the effectiveness measure can produce counterintuitive results. An alternative effectiveness measure provided by the MZ‐metric is recommended. © 1986 John Wiley & Sons, Inc.


Vitiligo is an acquired pigmentary disorder of the skin of unknown aetiology. Its prevalence ranges from less than 0.1 to more than 8% in various parts of the world [1]. It is characterised by presence of depigmented patches occurring over the skin and mucosa. Various theories like autoimmune hypothesis, neurogenic hypothesis, and self destruct theory of Lerner have been proposed in its aetiology [2]. Lichen planus is a chronic inflammatory condition of the skin characterised by plane topped purplish polygonal pruritic papules and plaques. About 0.5 to 1% population is affected by lichen planus among which the hypertrophic lichen planus constitutes about 4.7% of the cases [3]. The commonly affected age group affected is 20 to 49 years [4]. Although these two entities are encountered commonly in practice, their coexistence in the same patient is relatively rare, and also suggests a common autoimmune aetiology. CASE REPORT


The invention discloses a mobile phone and a method for setting contact photos in batch mode thereof. The mobile phone comprises a central processing unit and a storage unit, the central processing unit comprises a photo setting unit, and the storage unit comprises a contact photo folder. The method includes: step 1, the contact photo folder is built in the storage unit, and a plurality of photo files named by contact names are stored in the contact photo folder; and step 2, the central processing unit receives photo setting instructions, the plurality of photo files are read through the photo setting unit, and the plurality of photo files are respectively set into corresponding contact photos. Incidence relations between contact persons and the photo files are built. According to the built corresponding relations, the plurality of photo files are respectively set into corresponding contact photos so as to achieve batch setting of the contact photos.


This paper describes a project aimed at converting a legacy representation of English idioms into an XML-based format. The project is set in the context of a large electronic English-Polish dictionary which contains several hundred formalized idiom descriptions and which has been released under the terms of a free license. In short, the project consists of three phases: cleaning up the dictionary markup, extracting the legacy idiom representations, and converting them into TEI P5 XML constrained by a RelaxNG grammar created for this purpose and constituting a module that can be included as part of the TEI P5 schema. The paper contains general descriptions of the individual phases and several examples of XML-encoded idioms. It also suggests some directions for further research, which include abstracting the XML-ized idiom representations into general syntactic patterns and using the representations to automatically identify idioms in tagged corpora.


Finite element method (FEM) was used for the design of a piezoelectric rotary actuator by means of inchworm motion. This piezoelectric actuator can achieve large-stroke rotary with a high resolution. The common used cylinder rotor was replaced by one new designed rotor with a regular corrugated surface. The effect of the corrugated contact surface between the rotor and the stator was analyzed by finite element method. The contrastive simulations by the finite element method indicate that the stepping rotary angle can be improved by almost 4 times than the original one. This study will have some significance to the design and application of the inchworm type piezoelectric actuators.


Objective The objective of this research was to study the functional and clinical outcomes of fistulectomy versus fistulotomy in the treatment of simple perianal fistula. Background Anal fistula has been known as a common surgical ailment for over two and a half millennia. Current management remains dependent on surgeon preference between options such as fistulotomy and fistulectomy. Patients and methods This is a prospective clinical study that included 30 patients suffering from simple perianal fistula; patients were divided into two groups each containing 15 patients: group A was managed by fistulectomy and group B was managed by fistulotomy. Both groups were evaluated according to the operative time, postoperative pain, time of wound healing, postoperative complication, incontinence, and recurrence. Results There was a significant decrease in the operative time in group B compared with group A (P < 0.05), there was a significant decrease in postoperative pain in group B compared with group A (P < 0.05), and there was a significant decrease in the time needed for wound healing in group B compared with group A (P < 0.05). There was no significant difference in postoperative complications, incontinence, and recurrence between the two groups (P > 0.05). Conclusion Fistulotomy is a simple and effective method for the treatment of simple perianal fistula, as it has shorter operating time with less postoperative pain and less time needed for wound healing compared with fistulectomy, with the same incidence of postoperative complications, incontinence, and recurrence as fistulectomy.


The KEKB is a high luminosity accelerator, which has achieved the highest luminosity record of 2.1 10 34 cm -2 s -1 . It requires the precise and stable beam control to keep its high luminosity continuously. Slight change of the magnetic field may easily deteriorate the performance of the collisions of the very small and thin beams. The field measurement accuracy better than 10 -4 has been already achieved. The resolution of the measurement has reached to a few 10 -5 . But it is known by the beam studies that the field change less than 10 -4 may cause deterioration of the luminosity. The requirement on the stability of magnetic field will be stricter for future nano-beam colliders. We have studied the effects of the following conditions on the magnetic field by using some KEKB magnets: changes of the magnetic field due to air or cooling water temperature, changes due to initialization conditions, effect of excitation of the adjacent magnet and behaviour of the magnetic field under polarity change have been measured. These studies are not only useful for the existing KEKB but also important for future nano-beam accelerators.


The linear regression model, where the mean value parameters are divided into stable and nonstable part in each of both epochs of measurement, is considered in this paper. Then, equivalent formulas of the best linear unbiased estimators of this parameters in both epochs using partitioned matrix inverse are derived.


Normally cotton is picked by hand, however, due to acute labour shortage, mechanized harvesting is gaining momentum. Mechanized harvesting of cotton requires the application of harvestfacilitating defoliants, chemicals to shed the leaves before harvesting at an appropriate time and to ensure clean and smooth picking of the seed cotton.Chemical defoliants therefore, form an integral part of package for achieving clean pickings, early termination and quality cotton in developing countries.


In this paper,cationic rosin size is prepared by premixing extremely pure polyaluminum chloride (PAC) and dispersed rosin size (DRS).The cationic rosin size is characterized by FTIR,ant its zeta potential and particle size are analyzed.The results indicate that the rosin particle size changes significantly, the-C=O and-COOH of the DRS both react with PAC to form the aluminum rosin acid and the IR spectrum of cationic rosin size modified by PAC has two dissymmetric and symmetric flexible vibration absorbing peaks at1596cm~(-1) and 1425cm~(-1).The zeta potential of DRS modified with PAC from negative becomes of cationic.


Some of the symmetries inherent in a second-order translation invariant classifier model are described. The operational characteristics of this model for pattern recognition tasks such as fault and noise tolerance are explored. A particular optical architecture is detailed which exploits particular features of the model suited to optics and the operation of this system described.


Understanding how to communicate with individuals in other countries, particularly in a business environment, has become increasingly important in our global economy. This paper presents an effort by professors at Towson University in Baltimore, Maryland, and Sofa University in Sofia, Bulgaria, to engage students in a course project through the Internet, linking both countries and their universities. Using the Internet, the students worked in teams to prepare a study on the feasibility of starting a business in Bulgaria. The course required frequent communication and exchange of information between the teams through a web site created specifically for the course. The motivation for the project was to bring to life the cross-cultural scenarios typically read about in textbooks, but seldom experienced, and to apply and integrate business disciplines such as marketing and finance to a real-world situation. Our paper will describe the project, its successes, and its pitfalls with suggestions for how to overcome the latter.


Objective Present study aimed to research the mechanism of the use of 0.2% brimonidine tartrate eye drops in the treatment of optic nerve crush injury of rat.MethodsAnimal models of optic nerve crush injury were created in 60 SD female rats by clipping the exposed optic nerve at 2 mm in retrobulbar for 6 seconds with 78 grams of reverse forceps.The successful model was identified as Marcus-gun pupil without bleeding of fundus after operation.The animals were randomly assigned to model group and brimonidine treating group,and another 30 normal SD rats were used as the normal control group.The 0.2% brimonidine tartrate eye drops was topically administered at 2 hours before operation and after operation twice per day in the brimonidine treating group.The retinas from 18 rats were isolated after 3,7,21 days for RGCs counting by H&E staining,and the retinal ultrastructure was examined under the transmission electron microscope.The retinas from the other 72 SD rats (including normal,model and brimonidine groups) were prepared for the detection of bcl-2 and bax using immunohistochemistry l,3,5,7,14,21 days after the operation.ResultsNormal and almost normal retina structure was exhibited in rats of the normal group and brimonidine treating group,but disorder of cellular arragement and decrease of retinal thickness were found in the model rats under the optical microscope.The RGCs counting was significantly different among the three groups from 3 days through 21 days after operation with the considerably declination in the model group and brimonidine treating group compared with the normal control group (P<0.05-0.01).However,that of the brimonidine treating group was obviously increased in comparison with the model group (P<0.01).The expression of bax in rat retina was obviously reduced (P<0.01),but the expression of bcl-2 was increased in brimonidine group compared with the model group from 5 through 7 days after operation (P<0.01).ConclusionThe 0.2% brimonidine tartrate eye drops has a preventive effect on optic nerve crush injury of rat,and its inhibition on apoptosis is one of the mechanisms.

Key words:
bcl-2; bax; brimonidine tartrate; optic nerve crush injury


Aiming at the difficulty of infrared target detection of "low and slow small" unmanned aerial vehicles (UAV) in complex low-altitude background, this paper proposes a new target detection algorithm based on multiscale fusion filtering. Combined with spatial multiscale decomposition filtering and temporal multiscale difference processing, the algorithm can effectively overcome many difficulties such as complex Iow-altitude background interference, unknown target scale, unknown angular velocity and low target signal-to-noise ratio (SNR). The test result shows that the algorithm can effectively detect the UAV targets with different distances in complex Iow-altitude background, and the false alarm rate is low. The algorithm is realized in TI 6657 DSP and realizes 100Hz real-time processing of mid-wave infrared images with 640*512 resolution, which has been effectively applied to the large-field circumferential scanning infrared search system developed by ATR Lab.


Hot standby redundancy maintains the working order of a system, repairs offer restoration in case of failure, and preventive maintenance (PM) prevents trouble. Warranties provide assurance to customers, and a superior warranty signifies higher product quality. The running costs of redundancy, maintenance and warranties influence decisions during product manufacture. Therefore, this paper presents an economic production quantity (EPQ) model for a parallel system with maintenance, production, and free-repair warranty (FRW) programmes. The production system begins with a basic unit and produces conforming items. PM is performed after the production run period and is classified as imperfect or perfect. If the basic unit fails, it is repaired and returned to operation after perfect PM; the spare unit is online only during the repair time of the basic unit. The spare will produce some number of defective goods, which are reworked in the same inventory cycle. The hot spare is minimally repaired if it fails in its standby or online mode. In this study, an inferior item is defined as one that satisfies specifications on inspection and is usable but is likely to incur postsale servicing costs when sold under an FRW. The total cost of this EPQ model includes setup, holding, PM, restoration, minimal repair, and warranty costs. The optimal production runtime is determined by minimising the total cost. Several cases are discussed in this paper, and the proposed model is illustrated using a numerical example and sensitivity.


Praveen Kishore (email@example.com) is currently director, Integrated Child Development Services, Bihar. The long process of introducing a comprehensive Goods and Services Tax at the national level has thrown up many complex challenges. The question of the nature and structure of the agency for administering and collecting the GST is one of the most crucial ones. It appears that the existing institutional and organisational structure with multiple departments (one at the union and one in each of the states) would be maintained for collection of what is essentially a single tax (though with two components), thereby severely eroding most of the expected benefits of a national GST as well as putting a heavy burden on taxpayers. The influence of the bureaucratic complex and power politics of the organised civil services as well as a lack of political will are the major reasons for such a possible outcome. The need is to move towards a harmonised, modern and professionally managed national revenue agency for GST with a proper safeguard mechanism for preserving the fiscal federal nature of India and its states. India has been working to introduce a comprehensive Goods and Services Tax (GST) for almost a decade, though the wait now seems perennial. However, one thing that appears reasonably certain at this point of time is its inevitability despite so many roadblocks. GST as a tax policy and economic reform package is in itself a huge area and is not the focus of this study.1 Instead, this article is more about tax administration and (re) organisation of revenue agencies for effective and effi cient operationalisation of the proposed GST as it is widely recognised that "tax administration is tax policy", especially for developing countries. This applies even more so in the case of diverse, federal and competitive democracies like India. Fiscal federalism in India is tilted towards the union with important tax powers lying with the union government and with a constitutional mechanism for mandated rule-based devolution of tax revenue to states, which share major expenditure responsibilities. The institutional framework of revenue administration consists of two large union revenue agencies as well as a large number of stateand local-level revenue agencies which coexist, more of less oblivious of each other's existence. Against this backdrop, an integrated, modernised and harmonised revenue admi nistrative architecture is a sine qua non for successful execution of an ambitious tax reforms agenda, especially GST. However, the emerging administrative architecture for GST appears to be a severe compromise due to the overarching landscape of the bureaucratic complex and power politics of the Indian civil service as well as a lack of political will. If not tackled, it could lead us to a situation where most of the envisaged benefi ts of the proposed GST would be severely eroded.


These papers cover a range of topics which focus on: tool development to eliminate filter bubbles in social networks; understanding how peer influence impacts teenager's adoption of IS security guidelines; applying a social constructivist perspective on digital transformation; using decision support systems in the context of cyber-physical systems; and using an intelligent agent-based IS framework for dynamic demand environments.


Zhong, Y. and Liu, Y.T., 2019. Time-domain acoustic full-waveform inversion based on dual-sensor seismic acquisition system. Journal of Seismic Exploration, 28: 103-120. In many previous studies, attentions were paid to using dual-sensor seismic acquisition system for suppressing ghost waves, extending seismic bandwidth and improving resolution of migration, while few attentions were paid to full-waveform inversion (FWI) based on dual-sensor's seismic data. In this paper, we propose an acoustic FWI method based on dual-sensor acquisition system. We first review conventional acoustic FWI and compare it with our new dual-sensor acoustic FWI. Then we give the boundary condition for our dual-sensor acoustic FWI. Secondly, we derive new gradient equations with the spatial derivative of particle velocities replaced by the time derivative of pressure. Further, time-domain multi-scale strategy is conducted to reduce the nonlinearity of acoustic FWI. At last, the synthetic examples of modified Marmousi model are presented to demonstrate the efficiency and advantages of our dual-sensor acoustic FWI over conventional acoustic FWI. It can be found that, compared with conventional acoustic FWI, dual-sensor acoustic FWI almost does not cause extra computation and memory costs but can improve the accuracy of acoustic FWI.


BACKGROUND: In Italy there are an estimated 4 million patients suffering from diabetes mellitus (DM). The most important ocular complication of DM is diabetic retinopathy (DR), which affects about one third of diabetic patients.AIMS: To identify, within the Lazio Region, the cohort of patients starting treatment for DME in the years 2010-2016 and calculating the annual cost of therapy; and to assess the appropriateness of the drugs prescribed.METHODS: From the Health Information System of the Lazio Region were identified all subjects who, in the 2010-2016 period, had received at least one prescription for dexamethasone intravitreal implant (i.i.) or intravitreal triamcinolone or ranibizumab or aflibercept or bevacizumab. For the cohort of users selected, the appropriateness of the treatment were evaluated calculating the number of administrations performed in the first four months of the index prescription and the number of administrations performed during the 12 months of treatment.RESULTS: In 2016, 7,265 patients in the Lazio Region received at least one prescription of ranibizumab (43.0%), aflibercept (37.5%) and dexamethasone i.i. (19.5%). Among the 3,416 patients naïve at 6 months, who started treatment in the 2013-2015 period and who did not switch to different drugs, 78.7% started treatment with ranibizumab, 16.0% with dexamethasone i.i. and 5.3% with aflibercept. The mean annual cost for the treatment of a patient with DME and naïve at 6 months was equal to € 2,388; a total cost for only the naïve patients selected in the 2013-2015 period is therefore estimated at approximately € 8.2 million. The average annual cost of dexamethasone i.i. treatment was € 1,497, lower than that of ranibizumab (€ 2,562) and aflibercept (€ 2,485). The expenditure for patients receiving less than 3 administrations of ranibizumab or aflibercept in the first 10 months of treatment was estimate equal to € 1.3 million.CONCLUSIONS: The administrations of dexamethasone i.i. are in line with what is indicated in the prescribing information, while for ranibizumab and aflibercept a potential under-use has been identified. A greater appropriateness of the drugs prescribed, accompanied by an optimal adherence to therapy, would strongly reduce the current waste of resources.


Now that the Dublin Hospital system is in a fair way of being reformed, it may not be out of place to suggest that the voluntary principle of hospital establishment and maintenance might be tried on a more extended scale, not only without injury, but with very much advantage to the Dublin people. There is no particular politico-economic objection to the state endowment of hospitals, but a liberal measure of


Abstract:The White Trash Menace excavates a transnational Americas archive of twentieth-century fiction that grapples with the tense and tenuous ties between class privilege and whiteness that are endemic in post-slavery societies. Linking the writings of William Faulkner with a broad and diverse array of authors working across the American hemisphere, Soto-Crespo identifies a literary tradition that moves across the US nation's southern-most boundary and into the West Indies, the Caribbean coasts of South and Central America, and beyond in order to delineate the mutually imbricated histories of race and class that these regions share.


In this study we analysed the ability of individual thrips to transmit Tomato spotted wilt virus (TSWV) in a population of Frankliniella occidentalis over their lifespan as adults (about 10 days). In three experiments a total of 636 thrips were individually tested for their transmission capacity through leaf disc assays using four inoculation access periods (IAPs). Almost half of the transmitting thrips maintained the capacity to infect leaf discs in each of the four IAPs, confirming the persistent propagative nature of the transmission modality. Nevertheless, a relevant number of thrips (9.25% of transmitter thrips) was able to transmit in the early phases of their adult life (for the first two IAPs), but did not transmit the virus for the remainder of their lifetime. We compared the virus titer of these individuals at the end of the fourth IAP with that of individuals that maintained transmission ability in the four IAPs and showed a statistically significant difference. This difference could be evidence for recovery from TSWV infection in individual thrips.


To the Editor:— This year's book number is, as usual, great, but I disagree with Richard Armour's choice of books (208:139, 1969) If I were to be marooned on a desert island and could have only one book, I would choose neither the King James version of the Bible nor Richard Armour's suggestedNew English Dictionary, but rather Rowen'sPractical Art of Shipbuilding.


In Clinton v. City of New York, the Supreme Court struck down the Line Item Veto Act because it upset the finely wrought law-making process provided for in the Constitution's Presentment Clause. This Comment argues that the Court reached the right result in Clinton, but for the wrong reason. The Act gave the President the power to cancel certain budgetary items, thus vesting more law-execution power in the executive. Properly understood, the Act did not expand or alter the President's limited lawmaking veto power, as it is defined in the Presentment Clause. This Comment argues that the Act's reshuffling of power did, however, violate the separation-of-powers principle-one of the core political tenets upon which our government of limited powers rests. This Comment further contends that the Court should not have relied upon even an expansive interpretation of the Presentment Clause to strike down the Act, because as case law and history teach, the clause is directed at curbing the expansion of Congress's power, not that of the President. Rather, the Court should have examined in their full light the fundamental separation-of-powers issues at play. After determining whether the shift in power presented the several indicia of a separation-of-powers violation, the Court should have struck down the Line Item Veto Act on explicit separation-of-powers grounds, thus vindicating the long-term liberty interest that the principle centrally serves to safeguard.


The sophisticated arrangement of various equipment such that Solar Panel, Converters, Load and Battery Energy Storage System (BESS) together constitute a Solar Power Generation System with a battery backup. Battery Saving can be attained by application of certain automation programme on Load Management System. The Load Management System is an arrangement in which availability of load is made according to its requirement. Load Management System proved to be best way for saving energy and thus optimizing the sizing of PV panel and battery. In this article, the Efficient Solar Power Generation System and Load Management System are depicted by Simulation on MATLAB.


The pollution,given out by coal burning, is the main resource to cause our country' s atmosphere pollution. This paper analyses the effective mechanism of additive acting on coal burning process . Put forward that using additive is a practical method to reduce fuel coal burning pollution.


This paper aimed to reveal the research progress and prospect of space mutation rice breeding.Study on dry rice seeds treatment carried by high-altitude balloon;the mutagenic effects of hybrid rice's paternal and maternal carried by recoverable satellite or irradiated with γ-ray and combined treatment were carried out.


This paper presents the outcomes of a multi-year community design project undertaken by the Temple University School of Architecture, Landscape Architecture and Horticulture in collaboration with a neighbourhood in postindustrial
North Philadelphia. The process revealed the environmental design disciplines to be well suited, to initiate the important work of community building. It sought to engage the imagination and creative drive of non-academics, and to energize and more deeply inform the forum of professional education. In doing so, the project redefined the academic audience, its locus and pedagogic goals to reach beyond, and more deeply within, the institutional framework. Both process and outcomes have depended critically on the negotiations between the panoptic vision of a designer's map-world and ephemeral, labyrinthine experience of the real lived-world: between domains of the "tower" and the "street". Through this exchange of realities, both worlds were able to inform and participate in an authentic sustainable process of design thinking.


Abstract : In order to investigate the possibility of obtaining equivalent results between computer and paper-and-pencil test administration, selected subtests of the Armed Services Vocational Aptitude Battery (ASVAB) were programmed for cathode-ray-tube (CRT) administration. Speeded subtest items were presented two ways: one at a time, and in blocks of several items. Paragraph comprehension items, which were too long to fit on the CRT screen, were presented in three different scrolling modes. The graphical portions of items were displayed from edited code created by a commercial digitizer. These CRT subtests were then compared with their paper-and-pencil counterparts using Air Force recruits in a counterbalanced design. Results indicated that obtaining equivalence between paper-and-pencil and computer administration appears feasible. Graphical items present the least difficulty. Item production for one type of speeded subtest was best approximated by single-item CRT presentation, and for another type of speeded subtest by CRT presentation of blocks of items. Additional research is required for the 'too long' paragraph comprehension items in which more practice with the scrolling may be useful.


Reasearh guide for Introduction to research for Masters in Religion How to acquire articles when they are not available in Full Text


This thesis identifies three important shortcomings in firm internationalization research. The first problem is that the field has generally neglected the role of time and history, and evaluations ...


C l i n M e d International Library Citation: Stasolla F (2015) Assistive Technology for Children with Multiple Disabilities. Int J Psychol Psychoanal 1:001e Received: January 21, 2015: Accepted: January 22, 2015: Published: January 24, 2015 Copyright: © 2015 Stasolla F. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Stasolla. Int J Psychol Psychoanal 2015, 1:1


Renewable energy plays a vital role in contributing to sustainable development goals. The essential approach to facilitate development of renewable energy sources for electricity (RES-E) is a sound legal, policy, and regulatory framework for encouraging the use of, and overwhelming the barriers to renewable energy. This paper draws on the issue of legal and policy instruments in a specific context in which they facilitate the development of RES-E. Options of legal and policy instruments in this paper provide insights and lessons on how policy instruments are selected, designed and applied. This paper applies analytical, theoretical, doctrinal legal study approaches to analyze an appropriate instrument to deliver solutions for RESE. The analysis sheds new light on the types of instruments selected should be based in objectives, country conditions and energy sector structure. It is argued that the effectiveness of a particular legal and policy instrument for RES-E rely on how well it is designed and enforces.


The following study was undertaken to determine the possible seasonal variation of hemoglobin in a group of children between the ages of 21 and 44 months. The children in this study were attending a nursery school in New York. They came from a superior social group and their dietary and environmental conditions were above the average. The method used for the hemoglobin determinations was that of Cohen and Smith. 1 The accuracy of this method had been previously checked by Karshan and Freeman. 2 The blood was taken in the morning between the hours of 10 and 11, and at the same period in each month. Table I shows the individual figures (gm. of hemoglobin in 100 cc. of blood) for each child for each month that he was under observation. The age given is that at the time the first determination was made. Williamson 3 using the spectrophotometric method showed that the sex difference at this age was not significant, and in obtaining the averages shown in Table II the 2 sexes were used together. The same author also showed the small difference between the values in the second and third and fourth years, so that in this paper all ages were used together. It will be seen that, without exception, the February figures are all below those of November and that there is a rise in May but not to the November point, suggesting that the peak is probably during the summer months. The low point corresponds to the time of greatest incidence of upper respiratory tract infections 4 and to that of slowest growth 4 suggesting some common factor at work, probably to be found in environmental conditions to which city children are subjected during the winter months.


The Felsenkeller brewery in Herford was founded in 1878 and is one of the ten largest famil-owned breweries in Germany. A power/heat co-generation plant consisting of a gas-turbine with a waste-heat boiler (electrical output: 1.08 MW) and a natural-gas expansion system (electrical output: 275 kW) was commissionedf in 1990. Various optimization provisions for improvement of the thermal and electrical efficiency of the gas-turbine system have been implemented during the sybsequent operating period. The operating experience obtained from 5 1/2 years of operation of combined power/heat generation in a brewery is discussed in this report.


The IcEScr does not address environmental concerns for their own sake. For that reason, the EScr committee cannot make broad statements of law or policy on environmental issues but can only address the environment from a strict anthropocentric perspective. In other words, under the IcEScr, the environment has no intrinsic value, but is only valuable to the extent that it maintains or improves humans' abilities to enjoy their economic, social, and cultural rights. As a result, the committee has no self-standing general comment on the environment or the need for the development required to fulfil economic, social, and cultural rights to be "sustainable." (Baruchello & Johnstone, 2011, p. 110)


The purpose of this research was to describe the use of Indonesian idiom based on its shape, types, and source of Ranah 3 Warna novel by A. Fuadi The research method was qualititative research. The whole use of idioms which were found in Ranah 3 Warna Novel by A. Fuadi were 158 idioms. The use of idioms based on sources consists of idioms with names of body parts, idioms with names of natural objects, idioms with names of animals, idioms with names of plant parts, idioms with numerals, and idioms with color names. In learning Bahasa, this research was related to learning material. Ranah 3 Warna novel by A. Fuadi could be used as teaching material so that students understand the use of idioms in discourse better.


Currently used biotin-conjugated monoclonal antibodies (mAbs) and annexin V for the determination of the following: MP-borne phosphatidylserine, annexin V; T lymphocytederived MPs, mAbs to CD3 and/or CD4; leukocyte-derived MPs, mAb to CD11a; platelet-derived MPs, mAb to human platelet glycoprotein Iba (GPIba); activated platelet-derived MPs, mAb to P-selectin; apoptotic endothelial cell-derived MPs, mAb to CD31; activated endothelial cell-derived MPs, mAb to E-selectin; and MP-borne tissue factor, mAb to tissue factor (TF). Recombinant annexin V was produced and biotinylated in our laboratory. mAbs to CD3, CD4, CD11a as well as isotypematched IgGs, all conjugated with biotin were from Leinco Technologies (Ballwin, MO, USA). The mAb to GPIba was a kind gift from Dr F. Lanza (Unité 311 INSERM, Strasbourg, France); the mAb to CD31 was from Caltag Laboratoties (Burlingame, CA, USA). mAbs to P-selectin and E-selectin were fromAncell Corp. (Bayport,MN,USA), mAb to TFwas from American Diagnostica (Stamford, CT, USA). High binding capacity streptavidin-coated microtitration plates and chromozym-TH were from Roche Diagnostics GmbH (Mannheim, Germany).


N early twenty years ago a book appeared titled Lost Tribes and Sunken Continents, Written by Robert Wauchope, a highly respected scholar in the field of Mesoamerican studies, its aim was to examine the multitudinous theories which have been advanced to explain the origin of the American Indians. One chapter, "Lost Tribes and the Mormons," attempted to review the position of the LDS church on the topic of ancient Israelites in America. A brief passage from this chapter reads as follows.


Objective To study the effects of low concentrations mixed benzene exposure on early fetal loss (EFL) of female workers.Methods According to the executed standard, 42 women with mixed benzene exposure and 49 women without exposure were respectively selected as an exposure group and an internal control group in a large petrochemical corporation. In addition, 118 women in a large chemical fabric corporation were selected as an external control. The daily morning urines were collected at the beginning of the first menstrual cycle since no any contraception measures was taken. The total 15 084 urinary samples were collected respectively from 96, 146 and 435 cycles of the three groups. Then the urinary human chorionic gonadotropins (β hCG) were determined with immunoradiometric assay (IRMA) in order to evaluate EFL. Results The incidence rates (about 30%~40%) of EFL in three groups were closed to each other ,but incidence rates of EFL and their cycle rates from the female workers both in exposure group and in internal control group were higher than those in external control group, and the cycle rates of the women with EFL in exposure and internal control groups were higher than those in external control group ( P 0 05).Conclusion The present results suggested that the hazardous factors existed in the form of low concentration mixed benzene exposure in the petrochemical enterprise might result in EFL to some extents.


There were two rallies of medical students and trainee doctors, where 9,000 participants gathered. We performed polymerase chain reaction (PCR)-based universal screening for the participants using pooling at a tertiary care hospital. Around 609 (94%) of 646 participants underwent PCR tests for severe acute respiratory syndrome coronavirus 2; all of them tested negative. Our data suggested low transmission rates in open air mass gatherings when appropriate personal protective practices were followed.


This paper discusses the role of translators' (non) engagement in disseminating African-American literature in Brazil, with focus on translations of Native Son, by Richard Wright, undertaken by Monteiro Lobato (1944), Jusmar Gomes (1987) and Aurora Maria Soares Neiva (1995). We analyze the extent to which African-American literature could be interpreted as a model of inspiration for social criticism in regard to "racial" inequalities in Brazil. The paper investigates how the analyzed translations might get closer or not to a politically engaged perspective that could be reflected on the translators' options.


OF THESIS Inducing Stress Early and Reducing Stress late to Increase Soybean (Glycine max) Yield Relatively little change in national soybean (Glycine max) yield over the previous years have led many farmers to creating management regimes focused on plant stress. Field experiments consisting of two different relative maturity (2.8RM and 4.5 RM) soybean cultivars were established at three locations across Kentucky in 2013 and 2014. Each maturity group received a single application, sequential applications, or a combination of the following treatments: N'N-diformyl urea, lactofen, lambdacyhalothrin with thiamethoxam, and azoxystrobin with propiconazole. Relative maturity and yield environment*treatment interactions were observed to be significant (p 0≤.05). 4.5 RM soybean cultivars yielded significantly greater (800 kg ha) than 2.8 RM cultivars. Compared to the untreated check, no treatment in the yield environment*treatment interaction significantly increased yield. Significant yield decrease varied across yield environment, but was observed for treatments containing a combination of lactofen and N'N-diformyl urea. Application of stress management practices was not a consistent approach to improving soybean yield.


The formation of the oxygen dication, 0 2 is predicted to occur in significant quantities in the earth's upper atmosphere and in space. This species is diamagnetic and has been detec ted in various experiments on earth. It is very reactive. Cosmic rays may provide the energy needed to form the dication from the un charged molecule. The vacuous environment of space could insure a measurable lifetime for the ion. Properties and uses of diamagnetic oxygen are discussed.


Part 1 THE DESIGN OF ORGANISATIONS: The Structure of Organizations, Arthur Francis Principles and Practice in Job Design, Dr. David Buchanan. PART 2 EMPLOYEE RESOURCING: Manpower Planning, Dr. Stuart Timperley Recruitment and Selection, Tom Watson Appraisal, Dr. Gerry Randell. PART 3 EMPLOYEE DEVELOPMENT: Training and Development, Professor Robert Lindley and Keith Sisson Supervision, Bruce Partridge Management Development Philip Sadler Organization Development, Professor Andrew Pettigrew. PART 4 THE WAGE-WORK BARGAIN: Pay, Benefits and Conditions (Manual) Pay, Benefits and Conditions (Non-Manual), Professor Angela Bowey Developments in Harmonisation, Robert Price Discipline, Linda Dickens and Paul Edwards Communications, Barbara Townley Direct Participation, Dr. Barrie Dale Indirect (Representative) Participation, Professor George S. Bain. PART 5 THE MANAGEMENT OF THE PERSONNEL FUNCTION: Title similar to above, Keith Sisson.


This paper introduces the network environment structure with high availability, the function and implementation of hospital information system. In this system, the newest information technology is adopted. With its core of EMR, the system shows s a new model focused on patients, doctors and medical information, which keeps abreast of the international development.


Data in the cloud is increasing rapidly. This huge amount of data is stored in various data centers around the world. Data deduplication allows lossless compression by removing the duplicate data. So, these data centers are able to utilize the storage efficiently by removing the redundant data. Attacks in the cloud computing infrastructure are not new, but attacks based on the deduplication feature in the cloud computing is relatively new and has made its urge nowadays. Attacks on deduplication features in the cloud environment can happen in several ways and can give away sensitive information. Though, deduplication feature facilitates efficient storage usage and bandwidth utilization, there are some drawbacks of this feature. In this paper, data deduplication features are closely examined. The behavior of data deduplication depending on its various parameters are explained and analyzed in this paper.


In order to derive the instability criterion of atomic structures, such as thin film and nano-tube, an analytical method is proposed on the basis of the energy balance against the deformation. Taking into account all degree of freedom for atoms in system, the criterion is given as the positiveness of determinant consisted of the second derivation of energy against the infinitesimal displacement. This method is available for any deformation mode of any atomic structure as well as for any form of interatomic potential. As an application of this method, the ideal tensile strength of thin film is analyzed in order to understand the effect of surface on the instability. Critical stress is successfully extracted by the proposed method combining with the molecular statics simulation. Ideal strength eminently decreases for the films with the thickness of less than 10 nm.


The third UK Serials Group Automation survey was conducted in December 1988 and January 1989 and the detailed, four page questionnaire was sent to a total of 254 libraries. All UK library members of UKSG were approached; in addition, a number of libraries who sent delegates to the joint UKSGINational Acquisitions GroupIMARC Users Group exhibition of automated library systems in" Birmingham in November 1988 were also approached. The reason for including these additional libraries was to broaden the scope of the survey, particularly to public libraries, which are under represented in UKSG membership. Replies were received from 123 libraries giving a response rate of 48%. The breakdown by type of library was 70 academic libraries, 18 government libraries, 15 public libraries and a small number of medical, research and industrial libraries. The largest proportion of respondents (57%) were academic libraries. Due to the low response rate in some categories it was clearly difficult to identify and predict trends.


This scanning electron microscope image shows the carbon cathode of a carbon-dioxide-based battery made by MIT researchers, after the battery was discharged. It shows the buildup of carbon compounds on the surface, composed of carbonate material that could be derived from power plant emissions, compared to the original pristine surface (inset).


In recent years, numerous train derailment accidents caused by deterioration and high speed technology of railways have increased. Guardrails or barriers of railway bridges are installed to restrain and prevent the derailment of the train body level. On the other hand, it can result in a high casualties and secondary damage. Therefore, a Derailment Containment Provision (DCP) within the track at the wheel/bogie level was developed. DCP is designed for rapid installation because it reduces the impact load on the barrier and inertia force on the steep curve to minimize turnover, fall, and trespass on the other side track of the bridge. In this paper, DCP was analyzed using LS-Dyna with a parameter study as the impact loading location and interface contact condition. The contact conditions were analyzed using the Tiebreak contact simulating breakage of material properties and Perfect bond contact assuming fully attached. As a result, the Tiebreak contact behaved similarly with the actual behavior. In addition, the maximum displacement and flexural failure was generated on the interface and DCP center, respectively. The impact analysis was carried out in advance to confirm the DCP design due to the difficulties of performing the actual impact test, and it could change the DCP anchor design as the analysis results.


The control system of FLNR cyclotrons uses commercial SCADA FlexControl running under RTOS QNX 4. Good interaction possibility allows integrating self-made programs and commercial software. Basic ideas for inter-process communicating, data flow and overview of FLNR control system are described.


This study aims to investigate microwaves' effects on montmorillonite (MMT) reinforced polyvinyl alcohol (PVOH)/starch blends. Microwave irradiation at a power range 50–250 W was applied to the nanocomposites. Generally, when MMT was added to PVOH‐starch blends without microwave irradiation, the poor distribution of MMT particles in the polymer matrix impaired the mechanical properties of the composite. Microwave irradiation generally improved tensile strength of the nanocomposites. More powerful microwaves were needed for high amounts of MMT to obtain promising properties. A smooth morphology could be observed in SEM micrographs when the nanocomposites were subjected to microwaves, where the MMT particles were embedded into the polymer matrix. Infrared spectroscopy found a "red shift" effect where higher microwave power produced nanocomposites with overall lower wavenumbers, indicating better hydrogen bonding. This can be explained by high microwave power promoting the polar reorientation that enables better linkage between ‐OH groups from both the PVOH and starch. Finally, XRD analysis revealed that higher microwave power would improve the dispersion of MMT particles by reducing the agglomeration of MMT particles in the polymer matrix. In conclusion, the application of microwave irradiation is preferable to keep at 100‐150 W to achieve better properties of PVOH‐starch‐MMT nanocomposites. J. VINYL ADDIT. TECHNOL., 23:E142–E151, 2017. © 2016 Society of Plastics Engineers


The necessity for using the functional food products is dictated by the need of the human body for biologically active substances, which are insufficient in a normal diet. Currently, the assortment of domestic enterprises has almost no functional pasta. In the long term, borrowed European recipes will be presented on the Russian market, which can be an alternative to traditional types of products such as egg noodles and doughboys. The purpose of the research was to develop a recipe and technology for the production of functional "Rattles" pasta made of soft wheat flour, using German "Spätzle" doughboys as a prototype. Baking flour, linseed flour, milk powder and table eggs were used as the main ingredients. In order to increase the nutritional and biological value of a functional food product, it is advisable to additionally use ingredients that improve the functioning of the human organism. Such ingredients may include food additives such as spices of natural origin: turmeric and nutmeg. Using the technology of German doughboys "Spätzle" as a basis and the proposed set of ingredients as part of the recipe, innovative "Rattles" pasta has been developed. It is a functional product due to the content of flax flour and aromatic additives such as turmeric and nutmeg.


1 The defoliator beetle, Mesoplatys ochroptera Stål, is a serious pest of the legume tree sesbania (Sesbania sesban (L.) Merrill) in agroforestry systems in southern Africa. The survival of the overwintering stage of M. ochroptera and post‐ emergence longevity and fecundity of adults in sesbania fallows in eastern Zambia were quantified.


Our attention was first called to the possibility of unequal amounts of bismuth in measured doses of oily bulk bismuth suspension when working with tartroquiniobine. This is a suspension of the iodobismuthate of quinine and of sodium potassium bismuth tartrate in camphorated oil and has a metallic bismuth content of 6 cg. per two cubic centimeters. Because of the time required when doses are put up in separate ampules, as well as because of the expense, we used this preparation in 25 cc. amounts put up in wide-mouthed shallow bottles. The bottles were thoroughly shaken before the dose was removed; moreover, the suspension contained several glass beads to assist in more thorough mixing. At the bottom of the bottle we were occasionally surprised to find a heavy, thick, reddish deposit. This disturbing factor led us to examine several other bulk products that we were using, the potassium bismuth


Speed has become a crucial factor in ensuring both conventional as well as nuclear deterrence. Today with sophistication in missile defence systems, ballistic and cruise missiles need to be high speed weapon systems to be able to evade enemy missile defence systems and deliver warheads at the target accurately. High speed weapon systems can render missile defence system useless and it is usually difficult to intercept supersonic and hypersonic cruise missile technology. Missile defence systems have only increased the arms race with states developing more sophisticated weapon systems that can render the missile defence system null and void. While ballistic missile defence (BMD) has become a deterrent against ballistic missiles, states have also started to develop hypersonic technology vehicles that can be mounted atop ballistic missiles to negate the deterrent capability of the BMDs. Hypersonic weapons can become strategically destabilising if states start to develop the same. This is more so true in case the weapon system is fitted with nuclear warheads as is the case with China and Russia. While the ideal solution is to ban the weapon systems, such a solution is only utopian in nature. Hence, states should not nuclearize their hypersonic weapon systems if they are to maintain strategic stability.


This study aims to determine (1) how the implementation of learning mathematics using problem-based learning model of learning. In addition, to describe (2) how the students use the communication skills of mathematical learning model of problem-based learning. This study includes qualitative research, this kind of research using qualitative descriptive. The collection of data through observation, documentation, written test and interview. Data was taken two stages. The first stage is to give a written test instrument. The second stage is the interview of the subject selected. Making the research subjects were divided into three levels, namely a high skill level, ability level medium and low skill levels. Conclusion The results of this study were (1) reached learning the syntax or the suitability of the activities of teachers with lesson plans that have already been designed in using learning model of problem-based learning is progressing well with the percentage 84.97% or in the excellent category. While the activities of students during the learning progress with the learning model of problem-based learning has been performing well and is successful where the percentage reached 88.27% or in the excellent category.As for the students' mathematical communication skills in general in both criteria.