Perceptrons. A perceptron is a linear classifier of the form y = sign(σ i=1wixi+ b) where the weights w = (w1, . . . , wd) are trained using stochastic gradient descent. A perceptron is guaranteed to converge to some hyperplane separating two classes if the two classes are linearly separable (i.e., if there exists at least one hyperplane such that all points from Class 1 are on one side of it and all points from Class 2 are on the other side).


RNA-guided protease activity was recently discovered in the type III-E CRISPR-Cas systems (Craspase), providing a novel platform for engineering a protein probe instead of the commonly used nucleic acid probe in the nucleic acid detection assays. Here, by adapting a fluorescence readout technique using the affinity- and fluorescent protein dual-tagged Csx30 protein substrate, we established an assay monitoring Csx30 cleavage by target ssRNA-activated Craspase. Four Craspase-based nucleic acid detection systems for genes from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), norovirus, and the influenza virus (IFV) were reconstituted with demonstrated specificity. The assay could reliably detect target ssRNAs with concentrations down to 25 pM, which could be further improved by approximately 15,000-fold (~ 2 fM) through incorporating the recombinase polymerase isothermal preamplification step. Importantly, the species-specific substrate cleavage specificity of Craspase enabled multiplexed diagnosis, as demonstrated by the reconstituted composite systems for simultaneous detection of two genes from the same virus (SARS-CoV-2, spike and nsp12) or two types of viruses (SARS-CoV-2 and IFV). The assay could be further expanded by diversifying the fluorescent tags in the substrate and including Craspase systems of various species, potentially providing an easily adaptable platform for clinical diagnosis.


In this paper we present a Distributed objectoriented virtual computing environment on grid, called DOVE-G, an efficient distributed parallel programming environment which provides an integrated view of distributed objects and web services by enabling grid application object to access the web service, and vice versa transparently. Therefore, it can be used as a powerful framework for a semantic grid which needs provide a service oriented architecture based on web services.


In order to visually reflect the flowing tracks of reservoir fluid in five-spot horizontal well pattern,according to the potential superposition principle the pressure distribution equation of horizontal well pattern is obtained and the calculation method of seepage field streamline is presented.The streamline distribution diagram with horizontal well pattern is plotted and the regular of the streamline distribution is studyed.It is shown that the streamline distribution of horizontal well pattern is sensitive to the horizontal permeability,horizontal well length and production time.There is a reasonable well spacing under a given horizontal permeability,which can maximize the productivity of horizontal well.The well drainage area of production well is increased with the increasing of horizontal well length,which can improve the productivity of horizontal well.The longer the production time is the higher the sweep regionin of jection well is and the higher the recovery percent of reserves is.The streamline distribution plots can provide an important basis for analysis of remain oil,optimization of well pattern and injection strategy.


To enable the CNKI's Editorial Department to effectively use data resources in the manuscript management system and quickly make orderly and normative periodical contents,this paper created a contents' data resource by means of an Access query mode and designed a content template according to some practical applications,such as mail merge,tab and frame of Word.Using the template,we can make orderly and normative periodical contents in our Web by some necessary settings and adjustings.


This study is aimed at understanding the tensile ductility and compressive strength-enhancing dual function of nanoparticles in a concentrated magnesium alloy (AZ81) nanocomposite. Si3N4 nanoparticles were selected for reinforcement purposes due to the known affinity between magnesium and nitrogen. AZ81 magnesium alloy was reinforced with Si3N4 nanoparticles using solidification processing followed by hot extrusion. The nanocomposite exhibited similar grain size and hardness to the monolithic alloy, reasonable nanoparticle distribution, and nondominant (0 0 0 2) texture in the longitudinal direction. Compared to the monolithic alloy in tension, the nanocomposite exhibited higher failure strain (


As a part of my doctoral thesis, I studied the effect of phase fluctuations in two dimensional (2D) and three dimensional (3D) superconducting films of conventional s-wave superconductor, NbN, by measuring the electrodynamics response through magnetic penetration depth at low frequency and the complex conductivity at microwave frequencies. We show that the phase transition in 2D or quasi-2D superconductors can be reconciled with the standard Berezinskii-Kosterlitz-Thouless (BKT) transition when the small vortex core energy is taken into consideration. In 3D NbN films, we show that in presence of strong disorder, superconductivity can get destroyed by phase fluctuations even if Cooper pairs continue to survive in the system. Our study provides a paradigmatic picture of importance of phase fluctuations in 2D and strongly disordered 3D superconductors.


Software test is one of the important means to guarantee quality and reliability of the software.Software unit test,as a key step of software test plays an important role in the software test.Sufficient unit test is good for discovering and eliminating the bug in software,and the cost is low.Based on the practice of software unit test in the field of aerospace embedded software development,two mixed unit test methods are presented in this paper.The aim is to improve quality and efficiency of the software unit test.


The process of visual inspection of time-lapse seismic is improved considerably by analyzing multiple attributes simultaneously and by analyzing the resulting 4D anomalies in three dimensions. A pattern recognition method is used to combine complementary information from multiple attributes and detect 4D anomalies. The methodology consists of two phases; the analysis phase and recognition phase. The analysis phase aims at finding representative examples of 4D anomalies. In the recognition phase, these examples are used to train a neural network to recognize that the response of 4D anomalies differs from the background response. It is shown that the selection of examples is of crucial importance and should correspond to the objective of a time-lapse study. A comparison to conventional single attribute analysis shows the considerable reduction of non-repeatable noise. Moreover, it illustrates the potential of the method to steer the time-lapse analysis to distinguish different types of 4D anomalies. In general, the value of 4D seismic characterization projects might be reduced by non-repeatability noise. Nonrepeatability can be reduced by expensive dedicated acquisition methods. In this study it is shown that nonrepeatability can be reduced by the in-expensive detection technique presented in this paper.


In this paper we consider the effect of shear in the lines of force of a helical magnetic field on the drift instability of a plasma. The conditions are found in which such instability is possible.


Background To compare the hemodynamic and biological effects of high-adsorption continuous veno-venous hemofiltration (CVVH) with standard CVVH in septic shock. Methods: In a randomized cross-over clinical trial twelve patients with septic shock and multiple organ failure were enrolled at a tertiary intensive care unit. Patients were allocated to either 9 hours of high-adsorption hemofiltration (CVVH with 3 hourly filter change using AN69 hemofilters - 3F-CVVH) or 9 hours of standard hemofiltration (CVVH without filter change - 1F-CVVH). Results Changes in hemodynamic variables, dose of noradrenaline required to maintain a mean arterial pressure greater than 75 mmHg and plasma concentrations of cytokines (IL-6, IL-8, IL-10 and IL-18) were measured. A 9-hour period of 3F-CVVH was associated with greater reduction in noradrenaline dose than a similar period of 1F-CVVH (median reduction: 16 vs. 3.5 μg/min, p=0.036; median percentage reduction: 48.1% vs. 17.5%, p=0.028). Unlike 1F-CVVH, 3F-CVVH was associated with a reduction in the plasma concentration of IL-6, IL-10 and IL-18 at 9 hours and a significant decrease 30 minutes after additional filter changes (IL-6: p<0.01, p<0.01; IL-10: p=0.03, p=0.016 and IL-18: p=0.016, p<0.01, respectively). Both, 3F-CVVH and 1F-CVVH were associated with decreased plasma concentrations of IL-8 at 9 hours (p<0.01, p<0.01, respectively). In a confirmatory ex-vivo experiment IL-6 concentrations substantially decreased during 3F-CVVH (at baseline 511pg/mL and at end: 21pg/mL) whereas IL-6 concentrations increased in control blood (at baseline 511pg/mL and at end: 932pg/mL). Conclusions High-adsorption CVVH appears more effective than standard CVVH in decreasing noradrenaline requirements and plasma concentrations of cytokines in septic shock patients.


At the beginning of the 20th century, very ambitious goals were set for the production and consumption of biofuels. However, these predictions faced widespread public, political and scientific controversy about the negative impacts of energy crops, which completely changed the prospect of their global expansion. In the European Union, sustainability's concerns were incorporated into the guideline of political and regulatory interests after the impulse of reports from research institutes and critical notes from non-governmental organizations. Thereby, Directive 2009/28/EC emerged as a pioneering international governance instrument of the sustainability of biofuels, with the imposition of binding criteria to guarantee a production standard both in Member States and in third countries. Given the potential effects of this requirement on international trade, in order to avoid discrimination between similar products, the Directive must be applied in accordance with the agreements of the World Trade Organization (WTO). Therefore, using the hypothetical-deductive method, this article uses the case of the advanced regulation offered by Directive 2009/28/EC to analyze the interpretation's evolution of the General Agreement on Tariffs and Trade and the Technical Barriers to Trade (TBT) Agreement in the sense of allowing the adoption, by WTO member countries, of measures related to sustainability as a restriction of free trade.


ABSTRACT Stimuli-responsive nanostructures were developed as anticancer drug delivery carriers. To this end, poly(2-hydroxyethylmethacrylate)-b-(N-isopropylacrylamide) (poly(HEMA-b-NIPAAm)) diblock copolymers were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization with two ratios remarked with (1) and (2). Based on gel permeation chromatography, the molecular weights of synthesized diblock copolymers were 17802 (1) and 13090 (2) g mol−1. The pH- and thermoresponsive poly(succinyloxyethylmethacrylate-b-N-isopropylacrylamide) (poly)SEMA-b-NIPAAm)) diblock copolymers were obtained by reacting poly(HEMA-b-NIPAAm) with excess succinic anhydride in pyridine under mild conditions. Developed micelles with poly(SEMA-b-NIPAAm) (1) and poly(SEMA-b-NIPAAm) (2) diblock copolymers around pH of 3–4 at 25°C demonstrated the critical micelles concentrations (CMCs) of 0.026 and 0.019 g L−1, respectively. The average sizes of poly)SEMA-b-NIPAAm) micelles using dynamic light scattering (DLS) measurements at pH 3.0, 6.0, and 9.0 were 240, 190, and 150 nm, respectively. The core-shell poly(SEMA-b-NIPAAm) micelles at pH 3 and 9 were 100–200 nm. The lower critical solution temperature (LCST) of poly)SEMA-b-NIPAAm) sample was determined to be 40°C by ultraviolet-visible (UV-vis) spectroscopy. The micelles of diblock copolymers were formed to enhance the drug solubility in aqueous solutions. Doxorubicin hydrochloride (DOX)-loading capacity was 99.1%. The release of DOX acted better at 42°C compared to 40°C. The results confirmed that pH- and temperature-dependent release of this drug carrier was particularly useful and important for the anticancer drug delivery at the tumor-like environment. Therefore, the biocompatibility of diblock copolymer was confirmed by assessing survival rate of breast cancer cell line (MCF7) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The synthesized nanoparticles would have an excellent potential as anticancer drug delivery. GRAPHICAL ABSTRACT


In the first part of the paper, we consider various QALY (quality-adjusted life year) models in situations where health varies over time, and provide a theoretical analysis of model identification and parameter estimation from time trade-off and standard gamble scores. We investigate deterministic and probabilistic models, and consider five different families of discount factors in all. The second part of the paper contains a discussion of some recurrent themes from related literature. Among other things, we question the standard gamble method as a gold standard in health preference measurement, re-examine the role of constant proportional trade-off, and discuss so-called double discounting of QALYs. We also argue that it is not a matter of choosing between time trade-off and standard gamble procedures, since both types of scores are generally needed in order to be able to disentagle risk aversion from discounting. More broadly, we find that conclusions drawn from the analysis of models involving chronic health states only may not necesssarily apply to situations where health varies over time. One reason is that risk aversion and discounting may collapse to the same thing when all health states are chronic.


We show a spin superconductor in ferromagnetic graphene as the counterpart to the charge superconductor in which a spin-polarized electron-hole pair plays the role of the spin 2((h) over bar /2) "Cooper pair" with a neutral charge. We present a BCS-type theory for the spin superconductor. With the "London-type equations" of the super-spin-current density, we show the existence of an electric "Meissner effect" against a spatial varying electric field. We further study a spin superconductor/normal conductor/spin superconductor junction and predict a spin-current Josephson effect.


BACKGROUND: The role of L‐carnitine (LC) as the requisite carrier of long‐chain fatty acids into mitochondria is well established. Human red cells (RBCs), which lack mitochondria, possess a substantial amount of LC and its esters. In addition, carnitine palmitoyl transferase, an enzyme that catalyzes the reversible transfer of the acyl moiety from acyl‐coenzyme A to LC is found in RBCs. It has recently been shown that LC and carnitine palmitoyl transferase play a major role in modulating the pathway for the turnover of membrane phospholipid fatty acids in intact human RBCs, and that LC improved the membrane stability of RBCs subjected to high shear stress. RBC membrane lesions occur during storage at 4 degrees C; this study investigated whether the addition of LC (5 mM) to a standard RBC preservative solution (AS‐3) affected cellular integrity with 42 days' storage. STUDY DESIGN AND METHODS: A paired (n = 10) crossover design was used for RBCs stored in AS‐3 with and without LC. Both in vitro RBC properties reflective of metabolic and membrane integrity and in vivo measures of cell viability (24‐hour percentage of recovery and circulating lifespan) were measured at the end of the storage. In addition, the turnover of membrane phospholipid and long‐chain acylcarnitine fatty acids and the carnitine content of control and LC‐stored RBCs were measured. RESULTS: It was shown that LC was irreversibly taken up by RBCs during storage, with a fourfold increase at 42 days. Furthermore, as found by the use of radiolabeled palmitate, the stored RBCs were capable of generating long‐chain acylcarnitine. The uptake of LC during storage was associated with less hemolysis and higher RBC ATP levels and by a significantly greater in vivo viability for LC‐stored RBCs than for control‐stored RBCs: a mean 24‐hour percentage of recovery of 83.9 +/− 5.0 vs. 80.1 +/− 6.0 percent and a mean lifespan of 96 +/− 11 vs. 86 +/− 14 days, respectively (p < 0.05). CONCLUSION: A beneficial effect of the addition of LC to RBCs stored at 4 degrees C was evident. This effect may be related to both biophysical and metabolic actions on the cell membrane.


The Rotating Drum Spectrometer (RDS) experiment is planned to be placed onboard Ruscosmos Multipurpose Laboratory Module "NAUKA" on the International Space Station (ISS) in 2019. The experiment is designed to measure X-ray spectra of Solar flares using Bragg reflection from flat crystals. Additionally to the reflection of X-ray photons crystals produce luminescent light. In order to separate those physical effects during real experiment data analysis, computer simulations are necessary. Using Geant4 toolkit we simulated particle background, which were generated by several processes: photoelectric effect, Compton scattering and Bremsstrahhlung. In this paper we present luminescent light background estimations in the RDS instrument.


A recently proposed phenomenological model, which includes nonperturbative effects from dimension two gluon condensates, is applied to analyze the available lattice data for the heavy quark free energy in the deconfined phase of quenched QCD. For large qq separations, we recover previous results for the Polyakov loop, exhibiting unequivocal power corrections in the temperature. For the qq potential at finite temperature and finite separation, we find that a good overall description of the lattice data can be achieved once the condensate is properly accounted for. In addition, the model predicts a duality between the zero temperature potential as a function of the qq separation, on the one hand, and the quark self-energy as a function of the temperature, on the other, which turns out to be satisfied to a high degree by the lattice data.


This work presents an alternative method to simulate an Utility Interface (UI) consisting of a Power Electronics Converter (PEC). The proposed method is based on an equivalent resistor-inductor-capacitor (RLC) passive network circuit that resembles the output impedance of the UI, taking into account the internal resonant control characteristics of the UI. Although a controllable voltage source may emulate an UI converter, introducing an RLC network leads to a more accurate approximation of the complete UI simulated system. Comparisons are made using the frequency response of the complete system and the RLC-network circuit, and simulations are carried out on PSIM software. Results show a satisfactory dynamic and steady-state performance with a notable reduction of the elapsed simulation time. Therefore, the RLC-network-based UI could be applicable to fasten and to simplify simulations when multiples PECs are being analyzed within a complex environment, such as a microgrid.


This study aims at analysis of story about the crossing the East Asian Mediterranean, making storytelling model and its adaptation to cultural industry as tourism and education. For the purpose, this treatise tries to analyze the five stories which have been delivered in Korea from ancient times. The five stories are those in which 'Seo-Bok', 'Cheo-Yong', 'Heo Whang-Ok', 'Seok Tal-Hae' and 'Yon O-Rang and Se O-nyo' are the hero and heroine. In those stories, the East Asian Mediterranean is described as such space to find for a herb of eternal youth, strange man and woman come out from far abroad, and mutual cultures had been interchanged. Especially the cultural interchange were accomplished for the purpose of not only one"s search or development but also the other"s revolution or prosperity. As the result of analysis and interpretation of them, this treatise got the opinion the five stories are the evidence of mutual interchange of Korea, China and Japan, and it is possible to make a route to tour around the East Asian Mediterranean, and to educate and learn the people residing in East Asia that strange persons and foreigners in each society must be welcomed as justifiable citizen.


Mr Crawford's note on this subject, read at a recent meeting, reminds me of a method I gave to a class four or five years ago.


Preventing cells from killing themselves may save tissues from damage during disease [Also see Research Article by Yingfei et al.] If we knew how cells die, we might be able to prevent cell death, thereby saving vital tissues and organs in diseases as diverse as heart attack, stroke, diabetes, liver and kidney failure, and neurodegenerative diseases of the brain. Indeed, it has become clear from recent studies on anastasis, or reversal of apoptotic cell death (1), that cells can survive many severe insults and recover completely. On page 82 of this issue, Wang et al. (2) show that cell death can be prevented by blocking the breakdown of DNA that is a hallmark of a set of related cell death subtypes, grouped under the name of parthanatos (3).


In Reply.— Dr Frazier has rendered an opinion concerning "who needs pulmonary function studies." I tend to agree with his opinion that the allergic asthmatic child should be studied prior to surgery if at all possible. On the other hand, we never know whether our opinions are correct until some sort of study has been constructed and these opinions prospectively evaluated. To the best of my knowledge, there has been no study of preoperative pulmonary function testing in children. Without such studies, the questions of which abnormalities, how severe they must be, and what sort of operations are affected remain unanswered. This was the main point of my COMMENTARY. Dr Frazier may know who needs pulmonary function testing, but I am not sure that I absolutely know at the present time.


The crayfish described here was discovered while the author was carrying out an investigation on the biology of the crayfishes of central and southeastern Illinois.2 According to the collection data compiled during this investigation, this crayfish is limited in distribution to the southern part of Illinois and was not found in the collections which were made in the eastern and central parts of the state.


The dark writers of the bourgeoisie such as Machiavelli, Hobbes and Mandeville had always appealed to Horkheimer, who was himself influenced by Schopenhauer. Clearly, from their works there still remained ties to Marx's social theory. These connections were broken by the really nihilistic dark writers of the bourgeoisie, foremost among them the Marquis de Sade and Nietzsche. It is to them that Horkheimer and Adorno turn in the Dialectic ofEnlightenment, their blackest, most nihilistic book, in order to conceptualize the self-destructive process of Enlightenment. Although they no longer placed hope on its liberating power, inspired by Benjamin's ironic "hope of those without hope," they nonetheless refused to abandon the now paradoxical labor of analysis. We no longer share this attitude. However, under the sign of a Nietzsche restored by some post-structuralist writers such as Derrida and the recent Foucault, attitudes are being disseminated today which appear as the spitting image of those of Horkheimer and Adorno in the Dialectic of Enlightenment. It is the confusion of the two attitudes that I want to prevent. The Dialectic of Enlightenment is a strange book. A substantial part of the work was composed from notes taken by Gretel Adorno during discussions between Horkheimer and Teddy in Santa Monica. The text was completed in 1944 and published three years later by the Querido Press in Amsterdam. Copies of this first edition were available for almost twenty years. The impact which Horkheimer and Adorno made with this book on the intellectual scene of the Federal Republic of Germany especially during the first two decades after its publication, stands in curious contrast to the number of its purchasers. The composition of the book is equally unusual; it consists of an essay of


Cheminformatics of polyprenol, quercetin, ellagic acid are done to find out druggability of compounds. The interaction studies of drug and target are done and compared with standard drug available in market. The in silico techniques employed in pharmaceutical companies for the process of drug discovery are used. The compounds structures are taken and docking is done against protein responsible for arthritis. Automated docking process is followed to know the binding properties of the compounds with target protein. Based on binding energies and bonds formed in docking process, it can be hypothesized that ellagic acid, polyprenol and quercetin are the potent activators of protein hypoxia inducible transcription factors (HIFs). We discuss here the synergistic application of in silico and cheminformatic study of the HIF-2α, the target protein in arthritic pathway. By in silico analysis, it seems that ellagic acid is promoting the notable anti arthritic activity through the inhibition of HIF-2α protein, with the formation of 4 hydrogen bonds and binding energy -9.38. Hence, the proposed study can be used in the development of novel lead compound for future advancement in drug designing.


The purpose of this study was to examine current literature on wilderness therapy in order to identify any consistent themes. Ten studies were located and key data was identified on theoretical foundations, therapy components, populations being served, as well as outcomes. Results identified six theoretical foundations of wilderness therapy: Systems Theory/Family Systems, Eclectic Framework, Attachment Theory and Family Systems Theory, Group Therapy Theory, Motivation to Change Theory and Psychodynamic Theory. Numerous consistent themes were identified within wilderness therapy components, in addition to several independent components. Wilderness therapy was identified as a treatment modality for a wide range of populations and identified client problems, but most often the client was identified as at risk youth. Six studies included data on program outcomes, which identified positive benefits of wilderness therapy including positive client change, better family and client functioning and a sustained decrease in problematic behavior. Since this study was exploratory in nature, future research should aim at duplication of this study as well as utilizing additional case studies to gain a better understanding of the use of theoretical foundations and components of wilderness therapy A SYSTEMATIC REVIEW OF WILDERNESS THERAPY iii Acknowledgments I would first and foremost like to thank my research chair Dr. Lance Peterson, for all of your guidance, support, and encouragement throughout this project. Your extreme patience through all of the ups and downs was greatly appreciated. To my committee members, Dr. Mari Ann Graham and Danyelle Fisher, I cannot thank you enough for your time, feedback, and encouragement. You inspired me and challenged me to dig deeper and work harder. Without all of your patience and support this project would not have been possible. To my fellow classmates, I could not have picked a better group of people to survive both graduate school and this project with. Whether we were commiserating about fast approaching deadlines, questioning if we would really ever make it to graduation or laughing through the discomfort of role-plays, your support and encouragement for me were invaluable. I wish you all the best of luck in your future endeavors and cannot wait to see your successes! To my family and friends, thank you for understanding my absence over the past three years, but especially these past eight months, for working around my busy schedule, listening to me talk about wilderness therapy incessantly and never letting me give up. Your constant love and support has gotten me through these past three years and I will forever be indebted. Mom and Dad, thank you for instilling in me the importance of determination and hard work, both of which I needed to make it here today, I am forever grateful that you always believe in me. A SYSTEMATIC REVIEW OF WILDERNESS THERAPY iv


IN 1948 PUBLIC ADMINISTRATION1 had just been subjected to a critical examination of its premises and methods so severe as to produce a "crisis of identity." During the twenty-year period of this survey Public Administration expanded enormously in the range of its interests, and at the end of the period the features of the Public Administration of 1948 are recognizable only as the features of a child are recognizable in the adult. However, generally accepted answers to the questions of role and mission posed in the Forties still are lacking. In a period in which government is called upon to perform prodigies of administration unparalleled in history, the academic "sub-discipline" nominally charged with providing a base of ideas, education, and skills is having difficulty in defining its relations with its mother discipline, with the academic community generally, and with its external clienteles. The present situation displays a number of anomalies, contradictions, and ironies that it is useful to recognize before proceeding to historical review and analysis. Awareness of these contradictions and ironies will put the review and analysis in perspective, and in turn the review and analysis should throw light upon the contradictions and ironies.


This research was conducted in April, July and October 2013 at 8 (eight) stations: 1. Tj. Intan, 2. Tj. Tempurung, 3. Tj. Bunga Dalam, 4. Tj. Bunga dalam, 5. Tj. Burung, 6. P. Dabung, 7. Tasik Malaya, and 8. Tj. Harapan. This study aims to determine the relationship between several physic-chemical parameters and phytoplankton abundance. The results show the growth of phytoplankton biomass (chlorophyll a) was determined by high concentration of NH4 and NO3, while its growth is limited by turbidity (turbidity). Station that has high fertility in the Coastal District of Kubu Raya is Dabung Island. Keyword: water quality, chlorophyll a, coastal Kubu Raya district


BACKGROUND:  PLT concentrates are licensed for use up to a maximum of 5 days of storage. Increasing storage to 7 days would improve the logistics of supply and have the potential to reduce wastage.


Now a days the data security and data integrity are the two challenging areas for research. This work describes the concept of separable reversible data hiding technique that is related with internet security. When it is desired to send the confidential/important/secure data over an insecure and bandwidth-constrained channel it is customary to encrypt the cover data and then embed the confidential/important/ secure data into that cover data. With an encrypted image/video containing additional data, if a receiver has the data-hiding key alone, he can extract the additional data but the image/video content is unknown to him. If the receiver has the encryption key, he can decrypt to obtain only an image/video similar to the original one, but the additional data cannot be obtained. If the receiver has both the data- hiding key and the encryption key, he can extract both the additional data and recover the original image/video without any error by exploiting the spatial correlation in natural image.


A search apparatus and a search method are provided. A search apparatus includes a graph memory, a root node specification receiving unit, and a search unit. The graph memory stores data of a graph having nodes representing data elements and a link representing a relationship between the data elements. The root node specification receiving unit receives a root node specified from among the nodes in the graph. The search unit searches for an adjacent node which is connected to a target node via a link and which satisfies a search condition that at least one of the target node and the adjacent node has a predetermined attribute. The search unit searches for an adjacent node using the root node as the target node. The search unit iteratively performs a process of searching for an adjacent node using a previously determined adjacent node as the target node for a subsequent iteration to obtain a concatenation of adjacent nodes.


To analyze inner-enterprise cloud cluster performance, the role of workload analysis is of paramount interest to system designers. However, the ever-evolving nature of inner-enterprise cloud platforms such as diversity and spatio-temporal nature of workloads makes evolution diagnosing a challenging task. In this paper, we propose MuCoTrAna-Inner, an evolution diagnosing approach for a large-scale cloud data center based on comparative spatio-temporal trace analysis. Moreover, we present a case study on two representative big traces: Alibaba 2017 trace, and Alibaba 2018 trace. Novel quantitative findings along with the performance bottleneck inferences and recommendations based on workload analysis are provided. Our multifaceted analyses of the traces and new findings not only reveal interesting insights that are of interest to system designers and administrators, but also establish a new view to diagnosing the evolution of inner-enterprise cloud cluster based on trace analysis.


Objective To investigate the effect of juvenile rheumatoid arthritis(JRA) active phase serum on cell cycle, apoptosis of dendritic cell(DC) and cell proliferation of splenic lymphocyte, so as to approach a mechanism of DC in JRA further. Methods DCs were isolated from healthy murine(Balb/c)bone marrow ,and cultivated with the induction and differentiation of cytokine interleukin-4(IL-4),granulocyte macrophage colony stimulating factor(GM-CSF),and simulated to promote its maturity with lipopolysaccharide(LPS);allogenic splenic lymphocyte was obtained by common method;DC shape was viewed under light microscope.DC were identified about marker and function molecule,and detected the change of cell cycle and apoptosis during DC maturity with JRA serum by flow cytometry. Meanwhile, the influence of lymphocyte proliferation was detected by MTT method.Results JRA serum group,compared with normal serum group,showed that the number of cells in G1 phase decreased, but that in S+G2/M period increased (P0.05).Apoptosis cell population was a downtrend. The lymphocyte proliferation,compared with normal serum group, was obvious(P0.05),while with the co-effect of DC culture fluid and JRA serum,the proliferation role was more significant than that mentioned above(P0.01). Conclusions Cell proliferation was augmented and apoptosis may be of DC by JRA serum in active phase.JRA mechanism may be related to immunological regulation of DC cell cycle and apoptosis,as well as immunological amplification mechanism mediated by DC.


The largest shallow coal field in the world is in west China. The coal seams have thin roof and thick sandy overburden. The failure of thick sandy soil layer spreads to the ground surface in shallow seam mining, which will cause heavy disasters, such as dynamic ground pressure in coal faces and ground surface subsidence. Through physical simulation model tests, the development of fractures in sandy soil layer and on the ground surface is observed to be temporary structure of "arch beam" and periodic "arch rock pillar" structure. The "arch beam" mathematical model is set up; and the stress distribution in the "arch beam" is presented. Furthermore, the criterion of thick sandy soil layer failure is set up; and the position of periodic tension fracture is determined. This work provides basis for analyzing roof pressure control and surface subsidence.


In order to identify the authenticity and to find the difference of pigments used in the south and north parts of China, on ancient Chinese artworks, painted samples were collected from different ancient grottos, tombs and architecture from the Tang dynasty (AD 618–907) and the Ming dynasty (1368–1644) and these were evaluated by comparison with pure pigments mostly used in ancient artworks. A total of 23 ancient green, red, blue, black and white pigmented samples were collected from the Guangyuan Thousand Buddha Grotto (AD 618–907), Da Yun Cave (AD 618–907), Emperor Li Shimin Tomb (AD 599–649) and Bell Tower (AD 1368–1644) and were analyzed using X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscope with energy dispersive X-ray spectroscopy. Furthermore, each sample was analyzed for the presence of the 24 main elements using inductively coupled plasma emission spectrometry to understand the main contribution of the elements to the color, especially in the mixtured pigments. Among the 23 ancient painted samples, the main red pigments are miniumite (2PbO·PbO2), hematite (Fe2O3) and cinnabar (HgS), white pigments are anglesite (PbSO4), zinc white (ZnO) and gypsum (CaSO4·2H2O), green pigments are malachite (CuCO3·Cu(OH)2) and atacamite (CuCl2·3Cu(OH)2), and blue pigments are cobalt blue (CoO·Al2O3), chrysocolla ((Cu,Al)2H2Si2O5(OH)4·nH2O) and lazurite (Na3Ca(Si3Al3)O12S). In many cases, the painted colors are made of a mixture of pigments. It was revealed that six samples of GB-W (white), BT-W (white), GB-B (blue), DY-BLK (black), GB-G2 (green) and LS-BLK (black) were not in their original or pure form, and so they might have been repainted in the recent past, and possibly been retouched with modern colors. It is believed that the proposed analytical approach provides a bright future for the identification of original and fake painted artwork.


Normal 0 21 Normal 0 21 The purpose of this article is to discuss in general terms the relation between method and metaphysics in Descartes' philosophy. We intend to do it by opposing the Meditations on first philosophy to the Regulae ad directionem ingenii in respect of some themes in common. Our principal aim is to question the role of the intelectual evidence in the epistemological context of the Regulae and in the metaphysical context of the Meditations. At first we present some interpretations on this subject; after that we discuss the nature of doubt and the notion of evidence in the Meditations. As conclusion we suggest that a structural conflict between method and metaphysics takes place in the cartesian system.


profits made as enslaved sailors or vendors, yet others manumitted by family or friends. Trade and the multicultural character of local society necessitated that some sort of working relationship between the classes and 'races' was invented. Clearly Curaçao's social order remained organized along the lines of legal status and colour, yet there were ever more cracks in the system. And in one dimension, all inhabitants would end up being distinct from the rest of the Americas and even more so from the metropolis: their usage of Papiamentu as the lingua franca, an identity marker which has been preserved into the present. While the first written documentation in Papiamentu dates from 1775, references to a local language surface from the early eighteenth century. Rupert goes into great detail in highlighting the possible Iberian-African roots of this Creole language, and argues the case that a large proportion of Curacao's white population consisted of Sephardic merchants who contributed to the further development of Papiamentu. While the ascendance of this new Creole language is the most evident illustration of creolization, Rupert convincingly suggests that this phenomenon marked other dimensions of social life as well. Of course, there are questions to raise. I find it odd that this study virtually ignores the non-Jewish European segment of the population, as if these (mainly Protestant, but not exclusively Dutch) settlers and their descendants had not contributed to the island's regional trade connections and creolization process. Also, the discussion of creolization is quite narrowly focused on language. Thus, in her discussion on religion, Rupert discusses extensively why the Protestant and Jewish religions remained reserved for the European population while the Afro-Curaçaoans professed Catholicism, without exploring religious syncretism. Here, but also in other parts of her discussion of the 'unique' Jewish influence, her argument would have been nuanced and strengthened by comparisons with Suriname. One hopes that Linda Rupert will be among the ones taking up such challenges. For now, suffice it to state that Creolization and Contraband is a well-researched and lively study on early modern Curaçao. Rupert's work, as well as recent studies by Ramón Aizpurúa, Han Jordaan and Wim Klooster, have now finally brought the historiography of this Atlantic port city on a par with studies of other port cities in the Atlantic.


Second, using "should" can make you feel less than. We've already established that it is a judgmental word. Judgements cause us to question our thoughts, feelings and actions. To be fair, this can be a good thing at times, as it may help us make better and more skillful decisions. At other times, it can negatively impact our self-esteem and self-confidence, causing us to shrink away from things or avoid engaging for fear of repercussions and negative responses.


Abbreviations: alpha error, type I error; beta error, type II error; t-test, Student's t-test; σ, SD, standard deviation; p-value, t-test probability that the null hypothesis is false; type I error, false rejection of a true null hypothesis; type II error, non-rejected false null hypothesis SEM: standard error of the mean; SPM, Statistical process modeling; Z score, the standardized deviation of the random sample from the mean


The constitutional guarantees of Canadian Catholic education do not appear to be as convincing as they may once have been. The time is now ripe to defend such an education from the position of reason, while acknowledging the arguments made from the position of faith. Catholic education is important to a vast number of Canadians, and acknowledging its philosophical distinctiveness could play a vital role in how such an education could unify a diverse nation such as ours. Catholic education is crowned by a theology of education. That is its distinctive quality. Contemporary Catholic education, however, has come to rely on theology without much reflection on the various levels of knowledge which enable such a coronation. This reliance on theology, moreover, can only be secured through an integral philosophy which lays the foundation for knowledge of the deepest realities of the human person, the world, and God. Theology assumes this foundation; it cannot construct it. Contemporary Catholic documents on education have enunciated the intellectual principles of Catholic education, thus re-visiting the age-old relation between faith and knowledge, but in a new way.1 Church documents have also spoken about the dialogue between faith, culture, and education, and their influence upon the human person;2 of the importance of the preparation of the teacher as the communicator of knowledge and trutb;3 and of the necessity that teacher education must include an "interdisciplinary co-operation," an essential feature of education in the modem world.4 By relying exclusively upon theology in the pluralistic context, Catholic education has rendered itself indefensible. Theological distinctiveness is a claim that every religious tradition makes; it is hardly peculiar to the Catholic faith. Despite the constitutional protection of Catholic education in Canada, the theological distinctiveness of Catholic education becomes weak in light of the theological distinctiveness of every other religious group represented in the Canadian federation. Furthermore, an exclusive reliance upon theology also makes the integration of faith, culture, and education difficult. Integration, then, becomes the key word.


INTRODUCTION The day by day increase in consumption of meat received from chicken is causing harsh effect to environment, as the waste from the chicken birds, more particularly the feather are not properly treated. While in nature, the deterioration of feather is slow, generating sulfurous compounds, causing environmental problem. Feathers, which are almost pure keratin proteins, are produced in large amounts and constitute a waste by product at poultry processing plant. Feathers are made up primarily of keratin which is resistance to common proteolytic enzyme such as pepsin, trypsin and papain. World-wide poultry processing plants produce millions of tons of feathers as a waste product annually, which consists of approximately 90% keratin; the keratin is largely responsible for their high degree of recalcitrance if remain untreated. Keratinase are a particular class of proteolytic enzymes that display the capability of degrading insoluble keratin substrates (Brandelli, 2008) 5 . Keratinophilic fungi are generally considered as soil saprophytes. Soil that is rich in keratinous material is most conducive for the growth and occurrence of keratinophilic fungi. Keratin decomposition in soil leads to an increase in carbon, and nitrogen ratio in soil. They are therefore fast growing nonpathogenic keratinophilic fungi which can be utilized for the recycling of keratin in soil and may be exploited for their biotechnological potential in industry. Keratinase is an extracellular enzyme used for the biodegradation of keratin. Keratinase is produced only in the presence of keratin substrate. Keratinase attacks the disulfide bond of keratin to degrade it. Some microbes have been reported to produce keratinase in the presence of keratin substrate. Keratinase producing microorganisms have the ability to degrade chicken feather, hair, nails, wool etc. Keratinolytic enzymes are widespread in nature and are produced by several microorganisms including bacteria such as Bacillus sp., Fervidobacterium islandicum , Elizabethkingia meningoseptica KB042 , Pseudomonas aeruginosaKS1 and Actinomycetes such as Streptomyces sp. and fungi such as Chrysosporium tropicum , Trichoderma atroviridae , Doratomycesmicrosporus ; Paecilomyces arquandii ; Scopulariopsis brevicaulis ; Alternaria, Paecilomyces, Penicillium, Curvularia and several Aspergillus sp. Keratinase which are produced by these keratinolytic organisms could be used to degrade feather waste and further the digested products could be an excellent material for producing animal feed, fertilizers or natural gas.


Rationale: Treatment of acute myelogenous leukemia (AML) remains a challenge in elderly populations, those with comorbid conditions, and patients with poor performance status indices. The optimal choice for induction therapy as well as further agent selection is unclear, and current guidelines recommend enrollment in a controlled clinical trial.
 Methods: Institutional cases of AML via an electronic medical record query performed in November 2017 containing cases of AML in patients 65 years of age or greater from 01/01/2000 to 06/21/2017 were extracted. Instances of acute myelogenous leukemia were identified by ICD codes. Age, gender, induction therapy, cytogenetics, molecular analyses, and overall survival were collected.
 Results: A total of 61 cases of AML in patients aged 65 or greater were identified, with those having incomplete data being excluded from analysis. The mean age of included patients was 78.9 years of age, 35 were male and 26 were female. 60 confirmed deaths were recorded. 26 patients received conventional 7+3 (42.6%), 22 received a hypomethylating agent (HMA) (31.1%), 16 (26.2%) did not receive treatment.
 Conclusion: Our institutional data showed overall survival was significantly longer when treated with 7+3, 354 days (95% CI [93, 614]), vs. 61 days (95% CI [15, 107]). Similarly, OS was significantly longer when treated with HMA, 303 days (95% CI [23, 583]). Risk of death, accordingly, was as follows: 7+3 HR .347 (.179-.672), HMA HR .348 (.173-.703). Our institutional mortality data reasonably reflected SEER data analysis reported by Medeiros et al concerning untreated patients, but trended toward a greater OS for those treated with 7+3 or HMA. Registry data, as well as our institutional data, demonstrate a survival benefit to intensive chemotherapy and palliative chemotherapy, while controlled trials have not shown this benefit consistently in elderly populations. Practices regarding induction therapy vary greatly between institutions. Determination of which elderly patients to treat with intensive therapy remains difficult.
 References:
 Almeida AM, Ramos F. Acute myeloid leukemia in the older adults. Leuk Res Rep. 2016;6:1-7.
 Eleni LD, Nicholas ZC, Alexandros S. Challenges in treating older patients with acute myeloid leukemia. J Oncol. 2010;2010:943823.
 Medeiros BC, Satram-hoang S, Hurst D, Hoang KQ, Momin F, Reyes C. Big data analysis of treatment patterns and outcomes among elderly acute myeloid leukemia patients in the United States. Ann Hematol. 2015;94(7):1127-38.

 Chisti: Eli Lilly: Speakers Bureau; Medscape: Honoraria; UpToDate: Honoraria.


Consumer behavior literature shows that materialism and status consumption is associated to brand engagement in self-concept (BESC)(Flynn, Goldsmith, & Pollitte, 2016; Ronald E Goldsmith, Flynn, & Clark, 2011). Although many studies investigated the outcomes of materialism, however, a little research is known to investigate the association of materialism, status consumption and BESC in designers clothing (Flynn et al., 2016). The present study aimed at investigating the role of materialism and status consumption as predictors of brand engagement in self-concept (BESC). The results pointed out that both materialism and status consumption have a significant and positive influence on BESC. Moreover, status consumption is a stronger predictor of BESC as compared to materialism


The effects of various phenolic compunds with cupric ion on DNA cleavage under aerobic conditions was examined using fluorometric analysis. Information on the relationship between their structure and DNA cleavage was obtained. The activity of compounds containing an OH group at the 3-position of the C-ring such as epigallocate-chin and gallocatechin, was much stronger than that of the corresponding ester. It was also found that the 2-hydroxy or 2-amino ethyl moiety at the para-position of pyrogallol or catechol is essential for potent activity.


This paper presents the mathematical and structural model, simulation and computed torque control of the LapBot robot, developed by the Group of Investigation of Industrial Automatics, of the Universidad del Cauca, Colombia. First, a summary of the principal surgery assistant robots of the world is presented, and how they solve the problem of passing through the incision into the abdominal cavity. Based on this, the conditions that must be fulfilled by the robots of this type is exposed, and from these conditions the LapBot robot is designed. Its kinematics and dynamics model is shown, as well as the mathematical spatial restriction that incision represents. A control strategy based on the model (computed torque control) is implemented. Several trajectories defined in a plane and in a three dimensions space are used to validate the model and the control.


VANET play an important role for future automotive development since they enable wide range of services from safety, telematics, and infotainment to diagnosis being the primary design requirements. The routing of data packets in this fastchanging network is always the subject of intensive research. Vehicular networking in generic terms is an integration of multiple Ad hoc networking technologies such as Wi-Fi, WiMAX, Bluetooth, IRA, and ZigBee. The integration brings ease, accurate, effective communication between multiple vehicular components and/or between vehicles while on mobility as well incorporate intelligence in vehicle (termed as InVANET (Saravanan, Thangavelu, & Rameshbabu, 2009) with required agents and middleware.


The shiprecycling industry is an important part of recycling economy. This paper analyzed the factors influencing shiprecycling industry and the basic situation of shiprecycling industry in China,then put forward some proposals to our government and shiprecycling enterprises.


A new phenomenological model for realizing the current-voltage ( I-V ) characteristics of superconducting weak links has been proposed and studied. In this model, the total bias current to the weak link is decomposed in two parts. One part obeys the usual resistively shunted junction (RSJ) type current-voltage relation, and the other obeys the flux-flow (FF) one. It has been shown that the fitting results of the I-V characteristics agree quite well to experimental data. The model and analysis method presented here is quite general, thus the model can be applied to other types of superconducting weak links for both high- and low-T c material.


by Fran Bush. The following interview excerpts give a glimpse into a love and friendship that is over fifty years old and still going strong. The story begins in the late 1950s, when a friend brought Fran Bush to the...


The theory of imminent infringement has an important role in the protection of trade secret.This article breaks through the limitation of "imminent infringement" application by profoundly researching "imminent infringement",presenting the necessity of introducing that concept into trade secret protection,and opinions on how to apply injunctions to "imminent infringement".


In this study, we evaluated the effect of the 30-kDa N-terminal fibronectin fragment (Fn-f) on nucleus pulposus cells in 3-dimensional alginate culture and disc explant culture to determine the cellular response to this potential biologic mediator in vitro. In alginate culture, Fn-f stimulated MMP-9, MMP-13, and Fas expression and suppressed the expression of Type II collagen and aggrecan. In explant culture, Fn-f led to a marked decrease in GAG content compared with controls. These findings are consistent with the changes that occur during disc degeneration and support a possible role of the amino-terminal fibronectin fragment in the degenerative process.


A 40-year-old female with right hearing loss had sudden left hearing loss and tinnitus without vertigo. Both ears responded well to steroid (Rinderon) administration with improvement to 43dB on the left and 68dB on the right. We found a pulsating tumor on the right side of the neck, Raynaud's phenomenon and differences in blood pressure between the two radial arteries. The serum level γ-globulin was abnormally high. The CRP was highly positive, and the ESR was increased. Aortography showed a narrowed aortic arch with swelling of the aortic wall. The right neck tumor was biopsied, and the histopathological diagnosis was aortitis syndrome. Continuous steroid administration improved the physical findings and hearing, but mild tinnitus persisted.


This is a study of numerical control, its application, and the design of a numerical control program for a drilling machine. The study sought to obtain information on the function of numerical control; the different types of numerical control used by industry; and, the advantages of using numerical control.


The structure and functions of open system architecture intelligent machining module(OSA IMM) are investigated based on PC and DSP. The key strategies to realize the openness of the system are discussed. The signal processing network(SPN), reentrant plug in module(PIM), script command file(SCF) and standard function library(SFL) for intelligent control/monitoring of machining process are used to make OSA IMM open and intelligent. Two experiment systems based on the OSA IMM platform, the adaptive control system and the on line flank wear estimation using artificial neural network for turning operations, have been implemented for testing OSA IMM. The experiments have demonstrated that OSA IMM is characterized by satisfactory open system architecture and powerful real time ability, as well as intelligent computations. Based on the platform of OSA IMM, the control/monitoring systems for different objectives in the machining processes can be configured conveniently.


(51) Int. Cl. G06F 9/445 (2006.01) (52) U.S. Cl. ........................................................ T17/176 (57) ABSTRACT A computer-implemented method includes: collecting first data from first computers on which first software is installed, the first data including first characteristics associated with the first computers and adoption results of the first software: correlating the first characteristics with the adoption results to generate a correlation result; prior to installation of the first Software on a second computer, collecting second data asso ciated with characteristics of the second computer; and mak ing a determination whether to install the first software on the second computer based on at least the second data and the correlation result.


Abstract : Upper and lower bounds are obtained for the amount of linear test time required to demonstrate a specified lower confidence limit value on reliability when time to failure has a Weibull distribution with known shape parameter. These bounds are compared with the corresponding required test time when failure time has an exponential distribution. Equations are developed for the ratios of these times.


This paper proposes a target posture-oriented path planning method, where an improved A* algorithm and an optimized dynamic windows approach (DWA) are used at the global and local planning aspects, respectively. The method enables wheeled mobile robots (WMRs) to plan an optimal path under different posture situations which can shorten the time of achieving navigation task in certain scene. On the hand of global path planning, target posture and orientation information are added into A* algorithm to obtain appropriate path. At the level of local path planning, based on DWA, evaluation functions are optimized to make the robot movement adapting to curve global path and dynamic obstacle. By introducing rotation index to evaluate experiment results, the tests verify that WMRs can reasonably plan more efficient path compared with traditional path planning method, by satisfying various posture demand with the aid of the proposed target posture-oriented A* algorithm, and quickly avoid dynamic obstacles via the optimized DWA. Therefore, the proposed algorithm can be effectively applied to WMRs to execute various target posture demands navigation tasks.


The system of simulation solution of pipeline steels in stress corrosion cracking (SCO experiment under soil environment at home and abroad are summarized in the paper. Combined with the distribution characteristics of different corrosive soils over China,the issues determining SCC study system of pipeline steel under soil environment are discussed, which provides ways to investigate stress corrosion cracking under soil environment in China,and two simulating solutions are defined to simulate Yingtan and Kuerle soil environment based on the physicochemical properties of these soils.


Small scale UAVs are very promising platform for monitoring, surveillance, and emergency aid in isolated area. In this work, we developed an attitude control system for a quadrotor UAV. We obtained a linear model from experimental data using system identification method, PEM and designed a controller based on optimal control scheme. The obtained model and performance of controller were verified by performing simulation and experiment in real environment.


A novel AC_DC_AC converter circuitry which included a four_switch lowcost inverter with the capability of high power factor correction(PFC)is proposed,and a standard six_switch intelligent power module(IPM).Four switches in the IPMare used as an inverter while the rest two are used as follows:one is the switch for PFC;another one provides a path for the surge current.Further the reverse shunt power diode disconnects the rectifier and the DC bus bars.The experiˉmental results showthat this circuit reduced size has good running characters,which prove the practicability and potential of the configuration for AC motor drive applications.


State of the art on music similarity search is based on the pairwise comparison of statistical models representing audio features. The comparison is often obtained by the Symetrized Kullback-Leibler Divergence (SKLD). When dealing with very large databases (over one million items), usual search by similarity algorithms — sequential or exhaustive search — cannot be used. In these cases, optimized search strategies such as the M-tree reduces the search time but requires the dissimilarity measure to be a metric. Unfortunately, this is not the case of the SKLD. In this paper, we propose and successfully test on a large-scale a modification of the Symetrized Kullback-Leibler Divergence which allows to use it as a metric.


A novel treatment for prostate cancer, based on the Tvec /pembroluzimab technology – supported by activation of innate immunity is reported. The effect has been striking. Reduction of PSA from 60 μg/Liter to undetectable in 6 weeks, reduction of serum LDH from almost 1000 U/L to under 200 (normal) in 8 weeks, extensive necrosis in the tumor tissue as revealed by MR. The treatment gave no serious side-effects.


The career of John Wilkes was full of paradoxes. John Brewer's description of him as "a mercurial elusive rake" is apt in two senses: Wilkes eluded those who sought to crush him, and, posthumously, he continues to frustrate those who seek to understand him. He was a libertine who was lauded for political virtue; an aspiring aristocrat who rose to prominence as the self-proclaimed champion of those he dubbed the "middling and inferior class of people." He would succeed in achieving a remarkable rapport with his plebeian followers, yet all the while preserving an ironic detachment from them. The judgment of one of his contemporaries still contains solace for the historian: "It is … not altogether unpardonable if a writer should err in the portrait of a character so equivocal." Understandably, one response to the problematic issues of Wilkes's personality and conduct has been to steer clear of them, treating them as irrelevant to the supposedly larger questions of those movements conducted in his name or in response to his persecution. From this kind of perspective, his presence on the political scene is construed as merely the occasion and not in any significant sense the cause of campaigns assumed to have separate, deep-seated origins. Such an approach offers some advantages that have been realized in distinguished studies of the crusades with which Wilkes was associated. But it is also limiting in that it forecloses the possibility that the nature of the movements that swirled around him was influenced by the idiosyncracies of his character and behavior.


Entertainment is the symbol of modern urban life,and body-building Qigong well characterizes the national physical culture with Chinese traditional humanistic spirit.Faced with the present urban environment,its promotion in China's cities is of great practical importance.It satisfies the demands of people's leisure culture,regulates the body and mind health of people to some degree,and maintains and cultivates the cultural ecology.Nevertheless,the development of body-building Qigong in cities should follow some strategies.


used to vividly illustrate how the meaning of press photographs can be instantiated in news reporting. Also supporting the analysis are case studies developed around the reporting of particular events, which will offer readers essential help when they get started with their own research into news images. There are two minor deficiencies in the book. One is related to the title of Chapter 7, in which 'Text–image relations' may give readers the false impression that the chapter still has its focus on intersemiotic meanings, although it does refer to them. The other concerns the misprint of 'Table 3.5' (line 3, p. 69) for 'Table 3.4'. However, these cannot distract from the fact that this book can be highly recommended to those scholars who are interested in multimodal discourse analysis, journalism studies and communications studies.


It is a very haphazardstate of affairs when twenty or thirty men have to bepoisonedbefore adequateprecautionsare taken. Unfortunately the men do not always take reasonable care of themselves. Cleanlinessof handsand face, the use of rubber gloves, the use of proper respirators in dusty trades, adequateventilation, and exhaust fang to removethe dust or vapourare well known methods of prevention. I see noreasonwhy vacuumcleaners should not be used to remove lead dust also. Becausea high calcium diet favours storageof lead, a glass of milk at breakfast and between mealsis advisable. A daily dose ofsalts,by keeping the bowels free, will help to prevent absorption from the bowel.


There is an important growth of unmanned aerial vehicles (UAVs) performing planned missions in urban environments, which poses significant challenges to the research community. The possibility of collisions represents a critical challenge. UAVs can suffer collisions due to different causes external or internal to their flight plans. In this context, dynamic geo‐fencing is a useful approach, whereby each UAV is able to provide a prediction of its future positions within a limited time. These predictions could be used to detect conflicts, allowing to dynamically modify the flight plans so as to avoid imminent collisions. In this work, a conflict detection algorithm/method is proposed, implemented and tested on a central server performing real‐time conflict analysis for a large number of UAVs flying in the aerial space of a city (U‐Space). The architecture assumes that UAVs send their future locations to a traffic controller. This controller compares the predicted positions of nearby vehicles to detect possible conflicts. The results of this work demonstrate the feasibility of the proposed conflict detection algorithm and its interest to improve the security and efficiency in U‐Space environments. The server is able to track thousands of UAVs in real time with a conflict anticipation around 11 s.


Divided Supreme Court Allows State Law Antitrust Claims to Proceed Against Pipelines, Rejects Field Preemption Argument* In a decision that's received relatively little attention, a divided U.S.…


Chronic pain is a debilitating condition that has negative medical, economic, and quality-of-life impact. The aetiologies of chronic pains are diverse: arising, for example, from tissue damage induced by cancer, diabetes or herpes infection, or evolving from as yet undefined physiological processes induced during transition from untreated acute pain. Although several formulations of traditional and newer analgesic drugs are available to treat acute pain, the treatment of chronic pain requires additional considerations. Transdermal application by 'patch' has several desirable features. This chapter addresses some of the issues of chronic pain and transdermal application of analgesic drugs using the particular example of buprenorphine to highlight some of the major issues. The BuTrans transdermal system, FDA-approved in 2010, is indicated for the management of moderate to severe chronic pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.


Inspired by artists of the late 19th-century and early 20th-century, such as Étienne-Jules Marey, Marcel Duchamp and Anton Bragaglia, this thesis describes the development of dynamic motion sculptures abstracted from motion capture data combined with simulation and procedural modeling techniques. The methods described in this thesis present a robust, simulation-driven, and artist friendly process for manipulating animated point data into concrete and controllable structures. SideFX Software's 3D development package, Houdini, was used for nearly all aspects of the production. The node-based workflow streamlined the process of building, testing, and integrating custom tools and provided a system for procedural modeling and data-driven shading. A virtual museum tour showcases the sculptures generated from performance capture of a contemporary dance.


p. 17, but does not tell us what these collections were, who maintained them for what purposes, and who had access to them. The increased "professionalization" of the museums and their directors at the end of the century is central to Penny's entire argument, and he provides excellent examples to explain the "rigorous scientific standards" for collecting that this involved. But a brief overview of how the professional expertise of ethnologists changed near the end of the nineteenth century would have been helpful. In other words, was there, alongside "ethnologists' increasing specialization" (p. 206), a marked shift in the kinds of scientific training of prominent ethnologists at a certain point? In a similar vein, more discussion of who joined and supported the anthropological associations and societies (such as the Berlin Society for Anthropology, Ethnology, and Prehistory) and what relationships these associations had with other scientific institutions would have helped to clarify what constituted the "scientific community" (p. 98) of ethnologists during a period in which ethnology was only just becoming an academic discipline at universities. Ultimately important and impressive, however, is the general trend Penny traces regarding how these museums were viewed in their day and how their shape was determined by a variety of constituencies. Penny's evidence makes the case that the concessions made by the second generation of museum directors around the turn of the century were due less to the dictates of science and more to demands for popular accessibility and appeal. Indeed, Penny reads them productively as signposts of the larger pressures put on public institutions, despite their scientific nature, to make their collections and displays popularly acceptable. As such, this book (beautifully produced by the University of North Carolina Press) constitutes a fascinating and important chapter in the larger history of the popularization of science.


The rapid development of higher vocational education gives higher requirements to vocational english teaching.The purposes of this paper are to analyze the existed problems in Chinese vocational english teaching and introduce the ESP teaching into vocational english teaching under a mode of combination between working and studying in order to improve the practical and vocational applicability of higher vocational english for demands of the students.


The present issue of the journal collects several contributions coming from experts of different disciplines about water and the peculiar role it plays in ecosystems and living organisms. Water has been recognized from a very long time to be the matrix of life. Thales [1] stressed that water was just the primeval element and this statement has been repeated many times along the centuries. As far back as in 1892 Roentgen [2] held that water should exist as a mixture of two phases, but this statement was criticized in 1933 by Bernal and Fowler [3], who observed that since water is made up of molecules obeying a well-defi ned Hamiltonian, there was no room for the existence of more than one phase in the same thermodynamic conditions. This statement belongs to a reductionist point of view, according to which the properties of the ensemble are the macroscopic projection of the properties of the single molecule without any infl uence of possible supramolecular organization and collective properties. However, just fi ve years later, Kapitza [4] discovered the existence of superfl uid Helium, which was shown three years later by Landau [5] to be a two-phase liquid, suggesting the emergence of collective behaviours in liquids. The presence of a collective dynamics in water, however, received increasing recognition during the years. Piccardi's pioneering work [6] has shown that water is able to change its own properties depending on the dynamics of the environment (climate, Sun and Moon activity, external electromagnetic fi elds and, more in general, evolution of ecosystems) showing that, since the single molecule is too tiny to receive and store complex information, a supramolecular organization should be present. This same point of view has been adopted by Szent-Gyorgyi [7], who in the late 1950s pointed out the peculiar role of water in making possible complex biochemical processes. The role of water in promoting self-organization has been stressed by Prigogine and his school [8] in the framework of thermodynamics of irreversible processes (TIP) and furthermore by Tiezzi [9, 10]. In the last few years Pollack and his school [11] has been able to detect, attached to hydrophilic surfaces, a coherent phase of water (EZ water) and has described its peculiar properties. Very recently large fl uctuations of density and molecular ordering have been reported in water in the liquid state [12], suggesting the existence of two interspersed phases. In the meantime a theoretical understanding of the collective properties of water has begun to be achieved in the frame of quantum electrodynamics (QED) [13–15]. The convergence between TIP and QED has been investigated in ref. [16]. The properties of water have been further explained by the observation of the dynamics of living organisms, mainly by Voeikov [17], who showed that water is not a mere solvent but plays an active and dynamic role in the organization and regulation of biochemical reactions. This point is also discussed in ref. [18]. All of these approaches were discussed in the brainstorming meeting held in Ischia on 24–27 May 2009, sponsored jointly by the University of Siena, the GUNA SpA Company and Dr. Adriana Carluccio. The main contributions to this meeting are collected in the present issue of the journal. There are two types of papers:


This paper mainly studies the semantic segmentation algorithm for smart car scenes. Considering the real-time nature of the semantic segmentation algorithm in smart car scenes, this paper proposes a real-time semantic segmentation model based on an improved lightweight network. On the basis of the lightweight network MobileNet v2, a network with dilated convolution and attention modules is constructed as the backbone network for feature extraction, and pooling operations of different sizes are used on the dilated pyramid pooling module ASPP to encode surrounding Semantic information. On this basis, a lightweight semantic segmentation model LightSeg was constructed. Tested on a single RTX 2080Ti GPU, the model achieves a segmentation accuracy of 73.8% mIoU at a speed of 49.5 frames per second on the Cityscapes dataset.


Currently Enterprise Resource Planning (ERP) is an essential tool for companies looking for the automation of their processes, which is why several companies spend a lot of time and effort in selecting the ERP that fits the best to their needs. Despite the effort, it is often the case that this selection is made in an empirical way or through informal recommendations, which means that the best option is not always chosen. This paper presents a methodology for ERP selection using cloud computing technology, a technology that offers new services for the provision of software under the Software as a Service (SaaS) model. Several software options exist, specifically ERP systems, that exploit the advantages of the cloud such as availability, payment for use, service on demand among others. Additionally, the ERP system selected should be in harmony with the Ecuadorian legislation and day-to-day reality. The aim of the study is to expose and match the requirements of ERP systems, the requirements for a deployment of a software as a service (SaaS) model and the requirements to comply with Ecuadorian legislation, as to choose the deployed ERP in the cloud that best fits the needs of the Ecuadorian company. A proof of concepts is presented, which exemplifies the application of the methodology and to demonstrate the feasibility of our proposal.


The domain of randomness made a late entry in the teaching of mathematics, even if the idea of probability appeared as early as 1654, in the famous correspondence between Pascal and Fermat. Moreover, even if the relation between frequencies and such a notion had already been sensed, it is only with Jakob Bernoulli (1713) that the link between a probability and the frequency of an event in the repetition of random experiences was clearly established by the law of large numbers. The viewpoint on the articulation between the two domains has evolved a lot over the last two centuries. To some extent, their teaching at secondary level mirrors this historical genesis since, to take the example of France : on the one hand they appeared only in the late '60 in senior high school curricula; on the other hand the links established between probability and statistics have fluctuated a great deal in these curricula over the last thirty years. This reveals underlying epistemological and didactical difficulties that I will try to emphasize through an analysis of the new French curricula (Parzysz 1997).


With the growth of car navigation systems technology come a variety of enhancements aiming to increase user comfort and satisfaction. One such application is the appearance of methods for learning a driverpsilas preferences in making a choice between several routes. A driver may know his/her basic and most important factors in making such a decision, but may have these factors weighing in differently. Hence, machine learning methods can be applied to model the driverpsilas preferences, thus predicting the result of the decision process. This paper proposes a new method which combines a fuzzy expert system approach with learning automata.


INTRODUCTION: Glucose Transporter type 1 (GLUT1) deficiency syndrome is an inborn error of glucose transport. Clinical manifestations are secondary to reduced glucose transport across the blood brain barrier, including: refractory seizures, developmental delay, microcephaly, persistent hypoglycorrhachia with normal glycemia. The diagnosis is suspected with glucose CSF/glycemia <40 (NV:> 60) and confirmed by molecular study in SLC2A1 gene (cr1p35-31.3). Treatment is based on a ketogenic diet (KD). OBJECTIVE: To present the Chilean experience in diagnosis and follow-up of patients with GLUT1. METHODOLOGY: 8 records of patients with GLUT1. Clinical picture, biochemical exams, molecular study, nutritional status and macro and micronutrient with KD were recorded. RESULTS: 5/8 are men. Of the total 4/8 GLUT1 were diagnosed with mediana (Me) 9,0 years of age and 4/8 GLUT1 with (Me) 5,3 months. All had hypoglycorrhachia <40 mg/dl (range:13-30) without hypoglycemia (80-90 mg/dl). The CSF/blood glucose ratio was (Me) 0,33. At the time of diagnosis, they presented myoclonic seizures, ataxia, and paroxysmal movements without response to drugs. They started DK and it has stayed between 18 years to 1 month. The seizures ceased after md 5 days of starting KD in children who were diagnosed at (Me) 5,3 months. The distribution of the caloric molecule was: Lipids: 87-85% (MCT oil, alpha linolenic acid and docosahexaenoic acid), Protein: 10-8% (0,8 to 2,0 g/wt/day), Carbohydrates: 3-6 %. Fasting levels of beta-hydroxybutyrate acid has been maintained over 2,0 mM/l and after meals lower 5 mM/l. The fasting blood sugar level was (Me) 80 mg/dL (NV: 60-90), Total cholesterol: (Me)141 mg/dL (NV:<200), LDL: (Me) 77 mg/dL (NV:<100), HDL: (Me) 62mg/dL (NV:>40), Triglycerides: (Me) 63.6 mg/dL (NV:<150), Vitamin D serum: (Me) 45,3 ng/ml (NV:>38), potassium: (Me) 4,4 mEq/ L (NV:3,4-4,7). All of them are supplemented with L-carnitine, vitamin C, sugar-free multivitamins, calcium. 7/8 GLUT1 have molecular study (C.177del.p; c.1088G>A; c.420delG; c57delA; 969del-C971T; c.143G>A; c. 458G>C/p.R153P). According to nutritional status: 3/8 are eutrophic, 1/8 have malnutrition, 3/8 are overweight and 1/8 are at risk of malnutrition. CONCLUSIONS: In patients with refractory epilepsy, GLUT1 deficiency screening and early diagnosis is important considering that KD is a safe and effective treatment for improving neurological manifestations.


We propose GradTail, an algorithm that uses gradients to improve model performance on the fly in the face of long-tailed training data distributions. Unlike conventional long-tail classifiers which operate on converged - and possibly overfit - models, we demonstrate that an approach based on gradient dot product agreement can isolate long-tailed data early on during model training and improve performance by dynamically picking higher sample weights for that data. We show that such upweighting leads to model improvements for both classification and regression models, the latter of which are relatively unexplored in the long-tail literature, and that the long-tail examples found by gradient alignment are consistent with our semantic expectations.


BACKGROUND
Bemisia tabaci (Gennadius) is a major damaging agricultural pest and exhibits high resistance to pyrethroid insecticides. L925I (TTA to ATA) and T929V (ACT to GTT) mutations in para-type voltage-gated sodium channel (VGSC) are associated with resistance of B. tabaci to pyrethroids. Amplicon sequencing is a reliable and high-efficient method to detect the frequency of mutation linked with insecticide resistance.

RESULTS
Similar frequencies of L925I and T929V mutations were obtained by amplicon sequencing and Sanger sequencing (L925I: 0.3548 vs 0.3619; T929V: 0.6140 vs 0.6434) with overlap of 95% confidence interval in SX population of B. tabaci. In five populations of B. tabaci from China, the maximum and minimum frequencies of the two mutations were found in LN (L925I: 0.1126; T929V: 0.8834) and JS population (L925I: 0.8776; T929V: 0.1166) by amplicon sequencing. However, there was no significant difference in frequencies between L925I and T929V mutation. The sum frequency of L925I and T929V exceeded 0.9688 in all populations. In addition, a combining mutation, L925 + T929V (L925I and T929V located in same allele), was found in five populations by amplicon sequencing even though its highest frequency was only 0.0157.

CONCLUSION
We established an efficient approach for detecting frequency of mutation by amplicon sequencing. The frequencies of L925I and T929V in VGSC associated with pyrethroids resistance were detected in this study, which could provide foundational data for resistance management of B. tabaci.


We study the adsorption behavior of Ga on ~0001! GaN surfaces combining experimental specular reflection high-energy electron diffraction with theoretical investigations in the framework of a kinetic model for adsorption and ab initio calculations of energy parameters. Based on the experimental results we find that for substrate temperatures and Ga fluxes typically used in molecular-beam epitaxy of GaN, finiteequilibrium Ga surface coverages can be obtained. The measurement of a Ga/GaN adsorption isotherm allows the quantification of the equilibrium Ga surface coverage as a function of the impinging Ga flux. In particular, we show that a large range of Ga fluxes exists, where 2.5 60.2 monolayers ~in terms of the GaN surface site density! of Ga are adsorbed on the GaN surface. We further demonstrate that the structure of this adsorbed Ga film is in good agreement with the laterally contracted Ga bilayer model predicted to be most stable for strongly Ga-rich surfaces @Northrup et al., Phys. Rev. B 61, 9932 ~2000!#. For lower Ga fluxes, a discontinuous transition to Ga monolayer equilibrium coverage is found, followed by a continuous decrease towards zero coverage; for higher Ga fluxes, Ga droplet formation is found, similar to what has been observed during Ga-rich GaN growth. The boundary fluxes limiting the region of 2.5 monolayers equilibrium Ga adsorption have been measured as a function of the GaN substrate temperature giving rise to a Ga/GaN adsorption phase diagram. The temperature dependence is discussed within an ab initio based growth model for adsorption taking into account the nucleation of Ga clusters. This model consistently explains recent contradictory results of the activation energy describing the critical Ga flux for the onset of Ga droplet formation during Ga-rich GaN growth @Heying et al., J. Appl. Phys. 88, 1855 ~2000!; Adelmann et al., J. Appl. Phys. 91, 9638 ~2002!.#.


In experimental work on rabits after four months chronic intoxication with fluorides, there has been defined the mineral density of knee bones, by the method of densitometry, before and after the operation on their lengthening. As a result the regularity of forming distraction regenerate and participation of separate zones and whole bone in this process has been established.


Though the on-line learning environments provide scalable and automatic ways to present a content, forums and evaluate the progress of the students, they are still limited in their ability to evaluate complex activities such as correction of essays. Facing this issue, Peer Assessment (PA) offers a powerful solution. However, a major problem found when using PA is the presence of inadequate behaviours from students, which affect the learning and evaluation system. In this sense, this paper proposes a gamified peer assessment model, where the gamification elements improvement the motivational aspect of the students. In the experiments conducted, it was concluded that there were no statistical variations between the grades obtained compared to the experts, the correction time was reduced and the cost involved decreased 72.4%. The gamification encouraged students to use the platform: increased access (+64.28%), essays performed (+10.53%) and essays corrected (+20%).


Glioblastoma is the most common form of primary brain tumor. The incidence of this tumor is fairly low, with 2–3 cases per 100 000 people in Europe and North America. It is one of the most aggressive forms of cancer. Without treatment, the median survival is approximately 3 months. The current standard of treatment involves maximal surgical resection followed by concurrent radiation therapy and chemotherapy with the DNA alkylating agent, temozolomide. With this regimen, the median survival is approximately 14 months. For nearly all affected, the treatments available remain palliative.


THIS ISN'T HOW it happened! Who drew this?" The Provost character in Nathan Hale's Hazardous Tales: One Dead Spy (Hale, 2012, p. 26) poignantly responds to how the American Revolution is being portrayed. As scholars of comics and nonfiction literature, we take a cue from him by asking questions of texts. Colman (2007) defines nonfiction as "writing about reality: real people, places, events, ideas, feelings, and things in which nothing is made up" (p. 260). Fiction is seen as containing made-up material. Yet, by analyzing three pieces of graphic nonfiction, we question the function of nonfiction, consider multiple and contradicting truths within texts that hold that label, and see the possibilities in the blurring of genres that graphic nonfiction takes up.Fueled by the call and challenge for more nonfiction in classrooms, we ask how the medium of comics supports and complicates how we define and understand nonfiction. Can textual elements that blur conceptions of nonfiction as entirely true be used to help readers analyze representations of nonfiction, and therein, representations of history and lived experiences of disability? To address this question, we focus on two graphic novels commonly labeled as nonfiction, Nathan Hale's Hazardous Tales: One Dead Spy (Hale, 2012) and Drowned City: Hurricane Katrina and New Orleans (Brown, 2015), and one graphic novel that is typically labeled as biography or memoir, El Deafo (Bell, 2014).ScholarshipCONCEPTIONS OF FICTION AND NONFICTIONCommon conceptions about nonfiction and fiction include ideas that nonfiction is dry and only tells factual information, whereas fiction is engaging and relays a story (Colman, 2007). However, children's books found in the nonfiction section of the library frequently incorporate imaginative and inventive elements commonly associated with fiction. This delineation between fiction and nonfiction is becoming blurred in children's literature as books use components of both genres. Some of these texts are called hybrid, literary nonfiction, and creative nonfiction, while others are still classified as nonfiction (Colman, 2007).The conceptions of fiction-that those books are written for pleasure and use imagination-should also be attributed to nonfiction, because the information presented in nonfiction books can result in reading for enjoyment (Colman, 2007). This is not to say authors of nonfiction cannot use imagination in order to faithfully and accurately tell their story. However, the result can prove problematic for teaching fiction and nonfiction in simple, dichotomous ways (Colman, 2007; Moller, 2016). For instance, teaching fiction solely for plot, characters, and emotional themes and nonfiction for text structure and expository reports are ways instruction with these genres is typically divided (Colman, 2007). Teachers may not recognize the fictional elements in nonfiction or other books that blur genre lines, and these books may be difficult to find, but there is deep value in acknowledging and studying their intricate nature.NONFICTION AND THE COMMON COREWhile teachers are being asked to incorporate more nonfiction into their instruction since the advent of the Common Core State Standards (National Governors Association Center for Best Practices & Council of Chief State School Officers, 2010), they frequently are operating without the benefit of extended knowledge of nonfiction (Donovan & Smolkin, 2001; Rice, 2002; Shymansky, Yore, & Good, 1991) and often resort to teaching fiction and nonfiction in isolation without encouraging critical inquiry into the texts (Colman, 2007; Levstik, 2003; Moss, 2008; Pappas, Kiefer, & Levstik, 2006). Curricular changes expected by the Common Core State Standards propose that 50% of what elementary children read and write include "informational texts" (National Governors Association Center for Best Practices & Council of Chief State School Officers, 2010). …


ABSTRACT Comparative studies routinely demonstrate that Australia underperforms relative to other established democracies on measures of campaign finance integrity and the role of money in politics. Scandals relating to the influence of political donations have affected both major parties in recent elections, and record numbers of Australians believe that the government is run for a few big interests. Previous studies have focused on the problems of Australian political financing arrangements, and reforms at the state level, but little is known about public perceptions of the influence of money in politics in Australia. This paper examines these perceptions with data from the Australian Election Study covering elections from 1990 to 2016. Using multilevel modelling we investigate the role of election level and individual level characteristics on perceptions of the influence of major interest groups in Australian politics. We find that when the Liberal-National Coalition is in government, there is greater concern over the role of big interests in politics. At the individual level, we find that partisanship, ideology, being an electoral winner or loser, and economic evaluations affect citizens' perceptions of interest group influence.


Campylobacter species are known to the high optimum growth temperature (42℃) and the cause of enteritis in people. Erythromycin has a curative effect for enteritis caused by the bacteria. However, the rate of erythromycin-resistant bacteria was not well known until recently in Korea. Swine are one of sources of the infection with a Campylobacter species which cause the symptom of a high temperature. In this study, we cultured rectum fecal specimens of 100 pigs in an area of Buan-gun, Jeonbuk Province during July 2009. As a result, the detection rate of C. jejuni and C. coli and the rate of erythromycin-resistant bacteria for the separated Campylobacter species on the condition of high temperature were investigated. The possession or not of hipO and glyA gene and ciprofloxacin-resistant gene gyrA was also reviewed with biochemical characteristics and PCR.


The factors which affect the stability of mined-out area are quite complicated.Both the mining technology and human factors may cause disasters in mined-out area.Based on the analytic hierarchy process(AHP),this paper analyzes the stability evaluation indexes of 13 mined-out areas of Laoyachao ore-field by the way of qualitative analysis and quantitative evaluation.By constructing AHP model and comparative judgment matrix,but also through mathematic calculation and one-time inspection,a conclusion is obtained,which shows the geologic structure、ratio of rise to span、rock mass structure,maximum exposure area and etc.are main causes,therefore,the essential instable factors of mined-out area are found out,which will offer a good foundation to the future harnessing of this area.


One embodiment of the present invention is an optical cell identification method, and provides an optical cell identification method comprising the steps of: a) receiving an optical image of each of a plurality of wavelength ranges for a biological sample comprising a target cell; b) performing primary filtering by measuring cell fluorescence intensity from the optical images of all or one portion of the plurality of wavelength ranges; c) performing secondary filtering by measuring cell morphology from the optical images of all or one portion of the plurality of wavelength ranges; and d) performing tertiary filtering by measuring cell morphology from an integrated image formed by merging all or one portion of the optical images of each of the plurality of wavelength ranges.


I wish to inquire into the possible relationship of playing a sport to the doing of art. Is art a sport, or are sports art? Of course the question is not foolish. Are not sports and games play? Schiller maintained that art and play were related in that both were expressions of overflowing energy, Freud that both were wish-fulfillments, Santayana that both were spontaneous doings, done for their own sake. And when we pause to realize that aesthetic play is a special kind of play that requires order and control, we have the more narrowly directed arguments through Wittgenstein, Weitz, and Mandelbaum that the parallel is not simply art and play but rather art and games, both thought of as organized activities. But now I ask, what about art and sports, that most highly organized form of play? To begin at the beginning, we shall say that in order to play a sport, it is necessary that the prospective player step out of his or her ordinary, everyday world and enter into the game's rather different world. This means, first, to occupy an appropriate place on an appropriately marked playing field, let us say a gridiron; and second it means to take seriously the sport's special rules (e.g., not to move across the line of scrimmage before the ball is snapped), values (e.g., to hit), and objectives (e.g., to bring the ball downfield). In effect it is necessary for the player both to occupy a designated place on the playing field and to accept the rules, values, and objectives of the game. To accede only to the first obligation and to ignore or slight the second is to be a spoilsport, someone who physically occupies a designated position on the playing field but only pretends to enter its different world and take seriously the unfolding facts that the other players, the fans, the officials, and, to a certain extent, the poor


This letter describes a compact Wilkinson power divider using compensated spiral compact microstrip resonant cell (C‐SCMRC) resonators for harmonic suppression and size reduction. The size length of quarter wavelength transmission line is only 0.14 λg because of the slow‐wave characteristic. Furthermore, the proposed power divider rejected the 2nd and 3rd harmonic signals using the stopband of C‐SCMRC resonators. © 2006 Wiley Periodicals, Inc. Microwave Opt Technol Lett 48: 2382–2384, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.21961


A cute hemiparesis can develop in response to a variety of cerebral diseases including intracerebral hemorrhage and ischemic stroke, Pelvic stability training is an exercise protocol designed based on neurophysiological and biomechanical aspects of pelvic stability designed based on the performance of each patient so as to increase pelvic stability. pelvic stability training is carried out for 30 minutes, 3 times per week, for 3 weeks. Pelvic stability training (PST) exercises have been shown to improve motor function in the lower extremities both in muscle strength, and to help meet ADL.


Current research focuses on non-contact means to capture physiological signals like the heart rate. One promising approach uses videos (imaging PPG, iPPG). The common procedure to derive the heart rate by iPPG comprises three steps: segmentation of a region of interest, usage of colour information from that region to yield a pulse signal and analysis of that signal to estimate the heart rate. This contribution proposes a novel approach to yield a region of interest using a Gaussian mixture model based level set formulation. The proposed method aims to segment a homogeneous region on an individual basis. To that end, we model the probability distributions for the pixel skin and non-skin class by two separate Gaussian mixture models. The proportion of the posterior probabilities are then included in the formulation of the level set function. The procedure yields a region of interest, which is used to derive a pulse signal from its average intensity or additional processing steps. We tested the method on own data and data of the 1st Challenge on Remote Physiological Signal Sensing. It is shown that the proposed method can improve the results for heart rate estimation on moving subjects. The potential of our approach is underlined by the promising result in the challenge.