Abstract 1791 Introduction: Alemtuzumab (Al) consolidation has been investigated as a strategy to improve the quality and duration of remission after fludarabine (F)-based induction therapy for CLL. Whether pts with genomic high-risk disease, such as unmutated (unmut) immunoglobulin heavy chain genes (IGVH) and poor-risk interphase cytogenetic (cyto) abnormalities such as del(17p) and del(11q), benefit from this approach has not been systematically investigated. We retrospectively assessed the impact of these factors on induction outcome and survival from 2 completed Cancer and Leukemia Group B (CALGB) consolidation studies. Methods: CALGB 19901 and 10101 enrolled treatment naive high-risk Rai stage III/IV or active Rai stage I/II CLL pts. Pts on CALGB 19901 received F 25 mg/m2/day IV × 5d every 4 wks for 4 mos. After a 2 mo. observation period, patients achieving complete (CR), partial remission (PR), or stable disease (SD) received Al at 30 mg/dose 3 × weekly for 6 wks, IV to the first 56 pts and subq to the next 29. Pts on CALGB 10101 received up to 6 cycles of F 25 mg/m2/day IV × 5d and rituximab (R) 50 mg/m2 IV on day 1, 325 mg/m2 on day 3, and 375 mg/m2 on day 5 of cycle 1 and 375 mg/m2 on day 1 of cycles 2 through 6. Pts with CR/PR/SD at 3 mos. post induction proceeded to Al 30 mg/dose 3 × weekly for 5 wks after a 1 wk dose escalation. Response was assessed by NCI 96 criteria immediately before and again 2 months post Al. Progression-free (PFS) and overall survival (OS) were assessed by genetic risk group: IGVH (mut v. unmut), del(17p)/del(11q) (absent v. present). A 2-sided alpha of 0.05 was used for all tests. Results: Of 187 pts treated on CALGB 19901 and CALGB 10101, 117 (63%) received at least 1 dose of Al, with 80 and 78 pts evaluated for IGVH and cyto, respectively. Among pts with IGVH, no significant differences in age, Rai stage, or sex were observed between mut and unmut pts (p>0.20). Induction response differed by IGVH status, with a lower fraction of responding mut pts (62% vs. 87%, p=0.02). Of those with PR or SD after induction, most improved response with Al, but the proportion of pts who improved their response was not associated with IGVH (mut 60% v. unmut 53%, p=0.62). PFS was similar in both IGVH groups (p=0.50), but OS was inferior in IGVH –unmut pts (p=0.02), emphasizing limited options for salvage in that group. In the subgroup of pts with cyto data, there were no significant differences in pt characteristics (p>0.20) or induction response rates (89% v. 83%) between those with or without del(17p)/del(11q). The proportion of improved responses with Al was similar between favorable and unfavorable cyto groups (52% v. 59%, p=0.78), although 2 non-responding unfavorable pts failed to convert to response with Al. Both PFS and OS tended to be worse in the unfavorable cyto group (p=0.05 and p=0.03, respectively), as has been observed historically. High-risk cyto remained moderately associated with inferior outcome when controlling for other prognostic factors, as did the negative association of IGVH-unmut with OS. Notably, induction response was not associated with PFS in either subgroup (p>0.50). Conclusions: Al consolidation can improve the quality of response in pts with high-risk CLL after F-based induction, but pts with IGVH-unmut or del(17p)/del(11q) continue to show inferior survival relative to pts without these markers, which must be balanced against the reported risk for serious infectious toxicity. Outcomes for these challenging pts remain poor, and consolidation and maintenance strategies remain appealing. Less immunosuppressive novel agents, such as kinase inhibitors and immunomodulatory drugs warrant exploration in this context. Disclosures: Off Label Use: Flavopiridol and lenalidomide are off-label for the treatment of CLL.


It has long been considered a salient feature of Japanese society's modernization process, especially in comparison with those of Britain and other Western societies, that shono (peasants or small farmers) who cultivated small plots relying primarily on the labour power of their own families continued to account for a large portion of the farming population, even after the country embarked upon its course of capitalist development. This feature has been taken for granted for many years, with no serious inquiries being made into what implications it had for capitalist development in Japan. The year 1998, however, saw the publication of three books that together challenge the accepted wisdom. The three have nothing in common except that each in its own way analyzes with unprecedented intensity the operations of small farming households in the period from Meiji until around the time of World War I. The three, however, produce an unexpected collective resonance that may prove so seminal as to challenge fundamentally the conventional understanding about the labour market, or even the nature of capitalism, in pre-war Japan. This essay will assess the major contentions of the three books, and attempt to evaluate the methodological effectiveness of their analysis of the economic situation of the peasantry for understanding early Japanese capitalist development.


In August 1999, the American Society for Photogrammetry and Remote Sensing (ASPRS) and the National Aeronautics and Space Administration (NASA) Commercial Remote Sensing Program entered into a 5-year Space Act Agreement to combine resources and expertise for: baselining the remote sensing industry (RSI); developing a 10-year RSI market forecast; providing improved information for decision makers; and developing attendant processes. This paper summarizes the Phase I (Characterization and Baseline Forecast of the Industry) and Phase II (Characterization of Customers/Users and Determination of Their Needs/Requirements) survey results. Phase III (Validating Phases I and II), will include a technology assessment and will be completed in December 2003. Phase IV (Market Forecast) will be completed in December 2004.


The present invention relates to a color control method and device, it belongs to the field of image processing. The method includes the step of identifying a skin color area in the image; Steps to the raw color data of the pixel point in the skin color region statistics to obtain a raw average value and standard deviation of the raw pixel dots in the color area; Selecting a skin color region and the most similar skin color model specified on the basis of pre-set average value of at least one of preset color model for representing the skin color average value and the primitive type in the at least one pre-set skin color model; The raw color data, the method comprising: on the basis of the average value and the raw pre-set average value and standard deviation of the group set raw standard deviation, the specified skin color model, determining a target color data; Based on the target color data, and a step for adjusting the skin color region. The present invention was reduced and the color difference between the actual color after the adjustment were prevent image distortion sikyeotgo beautification effects do not have to increase the user selects a target color operation is simple and it is easy to realize with a simple algorithm.


s SPITE of intensive study in many laboI ratories, the final role of hypothermia as an adjunct to anesthesia and surgery has not been defined clearly. This is due, in part, to the still incomplete knowledge of the profound alterations in physiology which occur a t reduced body temperatures. However, clinical experience with the technic of body cooling has been extended, and with it, the safe rnanacement of many patients undergoing either cardiac or noncardiac operative procedures. It is the purpose of this report to review our experience with hypothermia in infants and children, outlining the method of anesthesia, surgical procedures and complieations, and to discuss our nhscrvations briefl?=.


The thesis deals with problems of disabled pupils ́education financing at secondary schools. Its aim is to create the integral survey about the disabled pupils ́schooling, to compare and analyse normative financing of the most expanded educational specialization in accordance with regions. Theoretical part includes national educational concepts and programs directed at handicapped pupils. Besides detailed characterization of the health troubles ́single types there are also described institutial schooling and normative financing of handicapped pupils. There are the analysed reports of MŠMT (Ministry of education and youth ́s psychical education) about handicapped pupils at the research part. Charts and graphs contain datas of pupils in the Czech republic according to health trouble ́s type, number of pupils at special classrooms and of integrated pupils during 2007-2012. The inseparable component of the research there is survey of pupils ́schooling in accordance with the schools ́promoters. Conclusion is devoted to detailed comparison of normative financing of the most expanded educational specialization 65-51-E/01 Stravovací a ubytovací služby (The board and accommodational service) in the first place for mental disabled pupils and pupils suffering with developmental disorders of learning and behaviour.


This work proposes a theoretical framework for explaining the end users' willingness to disclose their personal information to the IoT service providers, despite the known privacy risks. The Communication Privacy Management Theory and Privacy Trust Behavioral Intention Model are used as the backbone for the presented framework. The model is empirically validated by collecting data from 924 participants residing in Thailand and Singapore who are active users of at least one type of IoT service: smart home, smart healthcare or smart cities. The results suggest that trust, perceived privacy risks, perceived benefits and the level of information sensitivity affect the users' willingness to disclose their personal information. Certain cultural differences are also noticed from the two different country samples. Based upon the results, the research implications are discussed, and suggestions provided.


Objective To explore the protective mechanisms of Buyanghuanwu decoction(BHD) on MIRI.Methods The rabbits were randomly divided into three groups,including sham group,model group and BHD group.After pretreating one week,models of myocardial ischemia reperfusion injury were established by ligating the branch of left coronary artery.CK,LDH,SOD and MDA in serum were detected.Results Compared with model group,CK,LDH,MDA of BHD group were significantly decreased(P0.01) and the activity of SOD was significantly increased(P0.01),compared with other groups.Conclusion BHD can clean oxyradical and lessen MIRI.


The aim of this study was the realism movement in the properties, methods, and to introduce the types. At the same time involved in this movement and one of the most important figures of world literature to reveal the location of Erich Maria Remarque's realism. Remarque, has committed the biggest crisis of the modern era and the tragedy. War and genocide into exile in his own country at the age of tragedy in his own country but working in the most realistic manner Remarque works, works of this tragedy has left as a legacy to humanity he experienced one more favor. In this context, a closer look in to the author's works of art and tradition penned by the author in question is though to be important to mention where his standing in the tradition of art.


SUMMARY: The records of 107 patients with supratentorial astrocytomas, Grades 1 and 2, treated surgically between I960 and 1970 were analyzed. Abstracted clinical data was retrospectively analyzed with respect to the relative significance of different factors affecting survival. Twenty-eight patients were alive at the time of follow-up in 1974. Age, clinical grade at surgery and radiation therapy were the most important determinants of prolonged postoperative survival. The more malignant astrocytomas occurring in the Province of Alberta had previously been reviewed. The present study was carried out to demonstrate the relative influence of histologic grade of astrocytomas and to analyze the factors affecting postoperative survival in the low grade, supratentorial astrocytomas.


In view of the newly discovered and physically acceptable $PT$ symmetric and non-Hermitian models, we reinvestigated the phase structure of the ($g\phi^{4}+h\phi^{6}$)$_{1+1}$ Hermitian model. The reinvestigation concerns the possibility of a phase transition from the original Hermitian and $PT$ symmetric phase to a non-Hermitian and $PT$ symmetric one. This kind of phase transition, if verified experimentally, will lead to the first proof that non-Hermitian and $PT$ symmetric models are not just a mathematical research framework but are a nature desire. To do the investigation, we calculated the effective potential up to second order in the couplings and found a Hermitian to Non-Hermitian phase transition. This leads us to introduce, for the first time, hermiticity as a symmetry which can be broken due to quantum corrections, \textit{i.e.}, when starting with a model which is Hermitian in the classical level, quantum corrections can break hermiticity while the theory stays physically acceptable. In fact, ignoring this phase will lead to violation of universality when comparing this model predictions with other models in the same class of universality. For instance, in a previous work we obtained a second order phase transition for the $PT$ symmetric and non-Hermitian $(-g\phi^{4})$ and according to universality, this phase should exist in the phase structure of the ($g\phi^{4}+h\phi^{6}$) model for negative $g$. Finally, among the novelties in this letter, in our calculation for the effective potential, we introduced a new renormalization group equation which describes the invariance of the bare vacuum energy under the change of the scale. We showed that without this invariance, the original theory and the effective one are inequivalent.


This paper deals with the evaluation of electromagnetic influence of AC traction network on the overhead railway communication lines. The dependence of voltage on a convergence width of communication lines and traction network are given. The experimental research of harmonics in traction current and the theoretical investigation of their influence on communication lines were carried out.


The future sustainable development constitutes a critical issue at a global scale. It builds upon the concepts of combating poverty & inequality, mitigating climate change impacts as well as protecting natural & cultural resources through innovation & adoption of eco-friendly solutions. It is a human-centric approach that places people at the core of its priorities. Seventeen Sustainable Development Goals (SDGs) have now been set by the United Nations (UN) for the year 2030, each accompanied by a set of indicators measuring their performance. This paper focuses on the contribution of each sustainability indicator to the accomplishment of the respective goals, especially in case of drylands. A general overview of the SDGs & the relative indicators are analyzed. Then, indicators related to climate change impacts are explored following by an assessment of the contribution of these specific indicators to the management of drylands under climate change conditions.


With the development of urbanization and modernization, the problem of mobile children's schooling is more and more important in China. This paper addresses a theoretical framework for reflecting the role of local government and educational policies of mobile children from the perspective of educational demand. Results indicate that local government should use different tactics and bear different responsibilities to satisfy the multiple demands for education of mobile children. On one hand, local government must play an active role facing some kinds of educational demand of mobile children; On the other hand, the intervention of local government is limited in considering other kinds of demand. In a word, educational policies of mobile children are flexible and local government has its own choice in specific context.


All doctors are trained to tell stories: "This 45-year-old man was awakened from sleep by..." While it is possible that such a routine case presentation might include the fact that the patient is a truck driver or a former drug addict, such details are not considered as important by most presenters as the details of the patient's symptoms. Only after their training are doctors apt to learn differently, sometimes to their great surprise, the importance of their patients' lifestyles and environments to the care of their medical problems. In On the Ledge , Neil Skolnik writes of his 2 years at a family medicine clinic serving Philadelphia's inner-city poor. He admits that his writing is a "purging of frustration." These fine and interesting accounts of the patients he saw arose from his dismay at the living conditions of the inner-city poor for whom he had medical responsibility. He seems surprised at


1 Department of Mechanical Engineering Science,University Of Johannesburg, P. O. Box 524, Auckland Park Kingsway Campus, Johannesburg, South Africa. 2006. 2 Department of Quality and Operations management, University Of Johannesburg, P. O. Box 524, Auckland Park Kingsway Campus, Johannesburg, South Africa. 2006. 3 Department of Mechanical Engineering Science, University Of Johannesburg, P. O. Box 524, Auckland Park Kingsway Campus, Johannesburg, South Africa. 2006.


Editor Thank you for the opportunity to reply to the three issues raised in the correspondence1. D2 gastrectomy plus complete mesogastrium excision (D2+CME) focuses on separating each part of the proximal segment of dorsal mesogastrium (PSDM)2 from its bed, keeping the mesentery wall as intact as possible in the D2 field. However, conventional D2 lymphadenectomy, which aims at the dissection of lymph nodes in the D2 field, does not characterize the mesenteric body (PSDM) or maintain the intactness of the mesentery wall during mobilization. It is noteworthy that conventional D2 performed by skilled surgeons can enter the bloodless plane intuitively, which appears to be similar to D2+CME. In this way, D2+CME could potentially prevent cancer cells of metastasis V leaking from the mesentery envelope by keeping the mesentery wall as complete as possible3. Otherwise, free cancer cells from metastasis V or/and lymph node rupture could disseminate into the surgical field through breaks in the mesentery wall with high risk, regardless of the extent of lymphadenectomy. That is why our raw data show a surprisingly oncological benefit, although the long-term results of the trial on D2 versus D2+CME remain to be disclosed. In our study, PCR results of carcinoembryonic antigen (CEA) provide a semiquantitative assay for the detection of free intraperitoneal cancer cells. CEAL/H, CEA expression low before and high after surgery, indicates the presence of more free cancer cells leaking from the PSDM envelope than does CEAL/L. J. Gong Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China


Writing Teaching is facing new challenges and opportunities.Writing teachers should build up a reasonable optimizing knowledge structure as an important support to improve writing,teaching skills and the writing ability.Teachers should bring the leading role of teachers and the main role of students into full play in writing practice.Teachers should actively expand the writing scope to develop the students' noble character writ- ing and their spirit of non-intellectual factors of the culture.


In this article, we discuss the design and implementation of a novel DCN system, which utilizes a knowledge-defined NO-M to operate a HOEDCN cost-effectively and energy-efficiently. The motivations behind the proposed HOE-DCN system are the urgent need to address the scalability, energy, and manageability issues in existing DCN systems. To realize the knowledge-defined NO-M, we follow the principle of predictive analytics in the human brain to design three artificial intelligence modules based on deep learning and make them operate collaboratively. The proposed HOE-DCN system is implemented in a network testbed, and we conduct experiments that involve both control and data plane operations to demonstrate its advantages. The experimental results show that the HOE-DCN simultaneously achieves high-performance service provisioning and improved energy efficiency. Furthermore, by analyzing the pros and cons of the HOE-DCN system, we also point out several directions to work on in the future.


The Bosten charter was a bold pioneer and has been widely copied, but something more is needed to make it 100% satisfactory


T he first Aspen Lung Conference entitled "Symposium on Emphysema and the Chronic Bronchitis Syndrome," was held in 1958. It's purpose was to develop an understanding of what these terms meant and to begin to unravel the causes and factors associated with the prognosis. The original Aspen Emphysema Conferences were funded by contracts from a branch of the United States Public Health Service. The 8th Aspen Emphysema Conference was held in 1965. It focused on therapy, and chronic bronchitis and emphysema were redefined. Surgery for emphysema was briefly considered. Oxygen therapy was introduced as a possible solution for selected patients with advanced stages of COPD. Principles of home care and pulmonary rehabilitation were introduced. The next three Aspen Emphysema Conferences were on contemporary research in COPD and related disorders. Beginning with the 12th, these conferences have been supported by donations from industry and from private individuals. The 13th conference was the first to be published as a special supplement in CHEST, and this has been the tradition from that time onward. The 16th conference was on acute lung injury and ARDS. At that time, the conference's name was changed to the Aspen Lung Conference. The most common themes of the previous conferences have been COPD, the pulmonary circulation, asthma, and ARDS. A variety of more basic topics, including the relationship between the environment and the lung and the basic science of the lung, have also been covered. The 26th conference again dealt with COPD and helped us further understand the pathophysiology, structure, and function of disorders characterized by chronic progressive airflow obstruction. It has now been 16 years since COPD was the theme, and most attendees considered this an inordinately long hiatus in view of the explosion of knowledge based upon multidisciplinary research that is gaining momentum. This year's conference was on the "Mechanisms of COPD." Understanding mechanisms of disease forms the foundation for new therapies. This supplement contains state-of-the-art reviews, as well as abstracts of reports that were presented after the state-of-the-art presentations or in the poster sessions. In some cases, slightly expanded mini-papers are included. A special commentary by Professor N. G. M. Orie, MD, about the Dutch hypothesis and the masterful summary by Robert Senior, MD, will be appreciated by all who read this supplement. We hope the readers share some of the thrill that we felt as we attended the 42nd Aspen Lung Conference. We thank the Francis Families Foundation for their support of the Annual Parker B. Francis Lectureship. We greatly appreciate the generous support of all the sponsors of this year's conference, and we thank Mrs. Jeanne Cleary for her tireless work, which again made this conference a huge success.


Pseudoaneurysm vascular repair vascular injury, femoral artery puncture 937 no conflicts of interest SFA superficial femoral artery RSFA right superficial femoral artery PFA profund femoral artery Angio-CT Computer Tomography Angiogram MRI Magnetic Resonance Iatrogenic vascular trauma is more frequent today as a result of the increase in diagnostic and therapeutic femoral catheterizations. We present a case of iatrogenic profound femoral artery injury following standard ipsilateral access to SFA revascularisation. 57 years old men was treated due to RSFA total occlusion (TASC C). First puncture was unsuccessful and catheter was placed in PFA. Next attempt was successful and standard angioplasty and stenting of the RSFA were performed. Next day severe haematoma of the thigh was observed. Angio-CT revealed injury with huge false aneurysm from the first branch of PFA. After few days using contralateral approach few coils were implanted in the beginning of the injured arterial branch. Aneurysm was successfully cured (six months follow up). 20 science Most of the iatrogenic vascular injuries occurr during endovascular procedures, femoral vein catheterisation and hip arthroplasty. MEDtube Science Mar, 2014; Vol.II (1) 1. 2ND Department of General, Vascular and Oncologic Surgery, Warsaw Medical University, Czerniakowski Hospital, Warsaw Poland.


This paper presents the influences of quenching technologies (classical, with cooling in magnetic field, cryogenic, with cooling in the ultrasonic field) on the dimensional stability in time and the contact fatigue behaviour of some elements of ball bearings made from 100Cr6 (RUL 1) steel. From the analysis of the experimental data obtained it has resulted that the use of ultrasound for martensitic quenching of these steels ensures changes to the properties favorable to elements of ball bearings and may represent an effective way of increasing the quality of bearings; the technology is relatively simple, it does not require substantial constructive changes in the quenching machines and no further investment of large values.


When a stringed instrument, such as a violin, is subjected to an applied time‐harmonic force and the resulting velocity of the bridge is measured, the quantity usually referred to as the "input admittance" in fact functions as an output admittance. Its value can be inferred by loading the bridge with a known external impedance and comparing the velocities with and without this loading. In our experiment, the external loading impedance is a known mass, and the applied force results from an irradiating acoustic field. By taking data with two different field configurations, we can independently determine the four elements of the two‐dimensional input admittance matrix referred to the two possible polarization directions of the string vibration. We utilize the digital data acquisition and processing system that has been previously developed for radiativity measurements, in which an appropriate broadband stimulating signal allows a large spectrum of data to be obtained in a few seconds. Some results will be sh...


Effects of periodic helical deformations on the dynamo mechanism in RFP are examined using a simple electric circuit model. Modeling the plasma to toroidal and poloidal current channels, we use the method which switches mutual inductance matrices discontinuously on the condition conserving magnetic flux to simulate periodic onset and extinction of helical deformations. And even if helical deformations occur periodically, phenomena of continuous energy transports from a poloidal external power source to a toroidal circuit and toroidal flux sustainment with appropriate @ value are shown to be demonstrated using the proposed circuit model.


Military exploits in the Cold War often differed from conventional acts of war particularly in that they were, by necessity, invisible: In order to prevent nuclear conflict, crises needed to be kept secret, and were therefore not inscribed into cultural memory. Nuclear submarines are paradigmatic of this dynamic: As mobile nuclear missile silos, they played a central role in the balance of terror during the Cold War, effective because they remained passive and invisible. Cold War era submarine films, however, followed old genre traditions by conceiving the submarine as a tactical, mostly explorative and active weapon. It was not until the 1990s that a reboot of the genre emerged, which sought to make the depths of the ocean visible and memorable as a strategic location of the Cold War. Rather than portraying pure military actions, these movies tell stories of intercultural negotiation which, to prevent the outbreak of nuclear war, had to remain hidden under the surface of the sea. Title: The Cold War and the Sea: Politics of Memory and the Submarine Film


An algorithm is described for the selection of mod el structure for identifying multivariable mode Is of"black box" character. The algorithm receives as "input" a mode I in a given parametrization ...


The ADAM environment is both used for data analysis by Starlink and for data acquisition by the UK-involved observatories in Australia, Hawaii, and the Canary Islands. ADAM was originally hosted under VAX/VMS but is now at an advanced stage of a Unix port. ADAM comprises a parameter system, hierarchical data system, noticeboard system, error handling system, and other components. Originally a multi-tasking single processor environment, it has been enhanced to a multiprocessor environment using local or wide area networking. The Royal Observatory Edinburgh is producing a transputer version of the ADAM kernel to allow instruments which make use of transputers for data acquisition/control to integrate more closely with the ADAM software running at the telescopes. Communication into the transputer system is based on Ethernet carrying TCP/IP, which eases development toward a network of mixed VMS/Unix/transputer Telescope systems. The transputer system is being applied to instruments under development for the UKIRT and JCMT telescopes.


The invention relates to the field of drugs, in particular to a preparation method of a sustained release preparation containing ibuprofen mini-pills. The technical problem to be solved is to provide the sustained release preparation containing ibuprofen mini-pills. A relative substance detection method is added for the medicament by our company by reference to the British Pharmacopoeia. The medical property of the medicament is released stably and lastingly, and the safety and effectiveness of the medicament are really achieved. The adopted technical is as follows: weighing the following raw materials in parts by weight: 25-35 parts of ibuprofen, 3-10 parts of milk sugar, 1-5 parts of microcrystalline cellulose, 1-5 parts of hydroxypropyl methylcellulose and 10-15 parts of medicinal ethanol; then mixing the materials and spraying an adhesive into the materials to obtain the ibuprofen sustained release preparation. The preparation method of the sustained release preparation containing ibuprofen mini-pills is widely applied to the pharmaceutical field of the ibuprofen.


AIM: To investigate the expression of arginase(Arg) in periodontal tissues at different stages of disease progression in a rat experimental periodontitis model.METHODS: Fourty male Wistar rats were fed with high sucrose diet.Silk was ligated around the cervix of right first maxillary molars to induce periodontitis(experimental group).The left first maxillary molars remained untreated to serve as the control.Ten rats were sacrificed at the end of week 1,2,4 and 6.Expression of Arg in periodontal tissues at different stages was detected with immunohistochemistry staining and image quantitative analysis.RESULTS: Arg was scarcely expressed in normal periodontal tissues and was mainly expressed in macrophages and endothelial cells in the experimental groups.The Arg expression increased with the ligation time,reached peak at week 4,and decreased afterwards.CONCLUSION: Arg expression is positively related with the degree of periodontal inflammation.


This thesis illustrates the effects of environmental factors on pollen performance and its importance on gene flow. Pollen competitive ability between the wild and cultivated species of four genera belonging to Cucurbitaceae family was compared to evaluate the evolutionary potential for selection on pollen tube growth rate. A possibility of hybrids formation between these species was also determined through hand pollination. Effects of herbivory and nutrients on pollen performance and female selection were determined in Cucumis sativus and N. alata. In addition, a study on flower colour inheritance on Nicotiana alata was carried out with the aim of obtaining a possible genetic marker for future gene flow studies. Hybrids between wild and cultivated species were formed in some species of Cucurbitaceae indicating a higher possibility of gene flow. Differences in individual variations on pollen tube growth rate within and between species suggest that there is an evolutionary potential for selection on this trait. Herbivory and nutrient factors were found to have effects on pollen performance on Cucumis sativus and N. alata. The interaction of the two factors was also found to be significant. Nutrient was found to influence herbivory effect on pollen performance. Effects of genotype-by-environment interaction in cultivars of the studied species were observed. The study on the flower colour inheritance suggested that in some cultivars of N. alata, flower colour could be used as a morphological marker on gene flow studies. Because pollen performance influences gene flow, an understanding of the factors affecting pollen performance is fundamental when conducting risk assessment studies. Since plants function the same way whether they are the result of natural selection, human selection, or gene modified, findings from cultivated plants or wild relatives will aid in assessing the environmental effects of all future introductions of GM crops. (Less)


A wider use of polylactide (PLA) in applications like food packaging requires further material development in order to achieve the necessary properties such as heat stability as well as improved mechanical and barrier characteristics. In the NANOPACK project (www.nanopack.dk), funded by the Danish Council for Strategic Research, we are investigating nano-scale reinforcement of PLA based on organomodified-clays or layered double hydroxides (LDH) in order to achieve improvements in these properties.


This article aims to shift the conversation from politics to purpose in co-production research by introducing practice-relevant scholarship as a foundation for delivering impact through powerful ideas. The article is intended as an invitation to re-engage in research practice mindful of the multiplicity of impacts it can deliver. A greater sensitization towards delivering impact provides scope for forming important collaborations with a whole host of partners (across geographical, scientific/professional and practice fields).


PURPOSE: A rechargeable touch screen panel is provided to arrange switching element about each touch cell in non visual area, thereby recognizing a multi touch irrelevant to a point number. CONSTITUTION: A touch cell(60) includes a transparent conductive pad(50). The transparent conductive pad forms a capacitance. A switching device IC(Integrated Circuit) unit is connected with a transparent signal line in a non-visible area. The switching device IC unit includes a switching device for a signal detection(44). A switching device for a signal detection detects a signal in a transparent pad. A driver IC(70) recognizes a touch input coordinate from the detected signal.


Membrane glycoconjugates on the Leishmania parasites, notably leishmanolysin and lipophosphoglycan, have been implicated in attachment and invasion of host macrophages. However, the function of parasite surface Ag 2 (PSA-2) and membrane proteophosphoglycan (PPG) has not been elucidated. In this study we demonstrate that native and recombinant Leishmania infantum PSA-2, which consists predominantly of 15 leucine-rich repeats (LRR) and a recombinant LRR domain derived from L. major PPG, bind to macrophages. The interaction is restricted to macrophages and appears to be calcium independent. We have investigated the PSA-2-macrophage interaction to identify the host receptor involved in binding and we show that binding of PSA-2 to macrophages can be blocked by Abs to the complement receptor 3 (CR3, Mac-1). Data derived from mouse macrophage studies were further confirmed using cell lines expressing human CR3, and showed that PSA-2 also binds to the human receptor. This is the first demonstration of a functional role for PSA-2. Our data indicate that in addition to leishmanolysin and lipophosphoglycan, parasite attachment and invasion of macrophages involve a third ligand comprising the LRRs shared by PSA-2 and PPG and that these interactions occur via the CR3. The Journal of Immunology, 2004, 172: 4902–4906. critical host-parasite interaction the attachment to and invasion of host macrophages, the


It seems as though just a few years ago, business banking was pretty simple and straightforward. The typical dental practice had checking and savings accounts, and patients paid by cash, check or insurance. Then along came a dizzying array of bank offerings – credit products, online banking, cash sweeps and a myriad of other services.


We compare two known methods of extending a complex, unital, commutative normed algebra so as to include solutions to sets of monic polynomials over the original algebra. (One of these is a generalisation of a construction from the thesis of B. J. Cole and only applies to uniform algebras.) An example is given to show that they can lead to essentially different algebras.
Integrally closed extensions which generalise Cole's `universal root algebras' are also constructed .


A theory of the low-frequency phase fluctuations in the output of a semiconductor laser due to spontaneous emission is developed. The theory can be used as a tool to numerically calculate the linewidth of complicated laser structures, e.g., by use of the transfer matrix formulation. The results for the single Fabry-Perot laser are shown to be in exact agreement with the most accurate treatments published so far. Results are then presented for both DFB and F-P lasers with external optical feedback showing how the linewidth varies with the threshold gain, with the coupling coefficient, and with the external feedback conditions.


In the changing financial market, the price of financial products fluctuates continuously over time. The study of the static term structure of the interest rate on the market can no longer satisfy the actual needs, and the dynamic model is imperative. Compared with the static term structure, the dynamic model introduces a stochastic differential term on the basis of the static term structure model of interest rate. This paper shows some relevant models including Vasicek Model, Single-Factor Dynamic Model, Multi-Factor Dynamic Model, and Kalman Filter method. To conclude, in the multi-factor dynamic interest rate term structure model, Kalman Filter has many benefits. However, it still has actual limitations. The multi-factor Vasicek model still needs some analysis to find the error and do the correction. In the research of bond pricing, risk management, and other aspects, the multi-factor model should be the main direction.


Abstract : Britain's submarine-launched nuclear deterrent is due to go out of service by 2025. The final decision to procure and replace it with a new system has been delayed until 2016, the latest decision deadline the procurement timeline will allow. The decision to replace the British deterrent is beset with challenging questions. Britain has over one trillion pounds of national debt. The Ministry of Defence needs to make severe cuts to its already shrinking budget. The 2016 decision to replace the deterrent submarines will cost 25 billion pounds that are currently unallocated. The Conservative and Liberal parties within Britain's coalition government have opposing views on nuclear weapons. Contemporary global threats are ambiguous with regards to the relevance of nuclear weapons. Finally, Britain's only nuclear submarine base in Scotland is in jeopardy from an anti-nuclear Scottish regional government that is making great strides towards a 2014 referendum on Scottish independence. The debate on replacing Britain's nuclear deterrent is a difficult and uncomfortable problem that the coalition government does not wish to confront in the current parliamentary term. The thesis of this paper is that Britain must make a decision by 2016 to continue Britain's nuclear deterrent if it is to guarantee national security into the middle of this century.


Since the invention of sound diffusers three decades ago a substantial effort has been made to predict the acoustic behaviour of these structures. BEM methods are well established for this purpose after a systematic comparison between simulations and experimental data. Volumetric methods such as finite element methods (FEM) or the finite difference time domain method (FDTD) are not often used, due to their large computational cost. However, near to far field transformations (NFFT) can overcome that problem. Recently some of the authors have shown that the FDTD method is a useful technique to analyse the time domain signature of sound diffusers. In this paper a careful analysis of the performance of diffusers in the time domain ("time spreading") are reported, opening a new field of research.


BACKGROUND
We aimed to evaluate middle cerebellar peduncle (MCP) asymmetry by diffusion tensor imaging (DTI) according to the dominant hand.

MATERIALS AND METHODS
Sixty-four volunteers who met the exclusion and inclusion criteria were prospectively evaluated by DTI. Circular voxels of interest were drawn at the right and left MCP levels for all volunteers. The software automatically calculated the median values of fractional anisotropy (FA), mean diffusivity (MD), and number of fibers (NF). The volunteers were categorized as the right-handed (n=44) and left-handed (n=20) groups using the Dellatolas test. The mean values of FA, MD and NF were statistically compared between the two sides and the two groups.

RESULTS
In both groups, the mean value of FA for the right MCP was significantly higher than the left MCP (p=0.0016 and p=0.0032 for the right- and left-handed groups, respectively). In both groups, no significant difference was observed between the right and left MCPs in terms of MD and NF(p=0.75, p=0.69 and p=0.96,p= 0.46,respectively). There was also no statistically significant difference between the groups for the mean values of FA, MD and NF of each MCP (p=0.74, 0.26 and 0.26, respectively for the right MCP and p= 0.78, 0.37 and 0.54, respectively for the left MCP).

CONCLUSIONS
There is an asymmetry between the mean FA values of the right and left MCP. However, this asymmetry is independent of the dominant hand.


CAMBRIDGE, Mass. November 9, 2017 – Sage Therapeutics (NASDAQ: SAGE), a clinical-stage biopharmaceutical company developing novel medicines to treat life-altering central nervous system (CNS) disorders, today announced positive top-line results from two Phase 3 clinical trials with its proprietary i.v. formulation of brexanolone (USAN; formerly SAGE-547); Study 202B in severe postpartum depression (PPD) and Study 202C in moderate PPD. Brexanolone achieved the primary endpoint in both trials, a mean reduction from baseline in the Hamilton Rating Scale for Depression (HAM-D) total score compared to placebo at 60 hours (Study 202B: p=0.0242 for 90 μg/kg/h dose and p=0.0011 for 60 μg/kg/h dose; Study 202C: p=0.0160 for 90 μg/kg/h dose). Patients treated with brexanolone demonstrated mean reductions from baseline in HAM-D total scores of 14 to 20 points at 60 hours maintained to 30 days in both trials. Brexanolone was generally well tolerated and showed a similar safety profile as seen in earlier studies.


A variety of new derivatives of 4-pyrazolyl-N-(het)arylquinoline (VI) and (VIII) (32 examples in all) is synthesized via a multicomponent reaction approach.


................................................................................................................................................. i TABLE OF CONTENTS .......................................................................................................................... iii TABLE OF FIGURES ................................................................................................................................ v LIST OF TABLES ..................................................................................................................................... vi 1.0  INTRODUCTION ............................................................................................................................... 1 2.0  REACTOR GEOMETRY AND CORE POWER DISTRIBUTIONS ........................................... 2 2.1   Nominal Element Geometry ..................................................................................................... 3 2.2   Core Power Distributions .......................................................................................................... 4 3.0  PROPERTIES OF MATERIALS ..................................................................................................... 5 3.1  Thermal properties of Cladding and Structural Components.................................................... 5 3.2  Fuel Thermal Properties ............................................................................................................ 6 4.0  INSERTION OF EXCESS REACTIVITY ....................................................................................... 9 4.1  PARET/ANL Model ................................................................................................................. 9 4.2  Forced Convection Cases ........................................................................................................ 10 4.3  Natural Convection Transients ................................................................................................ 21 4.4  Concluding Remarks ............................................................................................................... 22 5.0  LOSS OF PRIMARY COOLANT FLOW ..................................................................................... 24 5.1  RELAP5 Model ...................................................................................................................... 25 5.1.1  Conservative treatment of the peak channels .......................................................................... 25 5.1.2  RELAP5 treatment of fins on the fuel plates ........................................................................... 26 5.2  Initial Conditions and Assumptions ........................................................................................ 31 5.3  Results ..................................................................................................................................... 32 5.4   Conclusions ............................................................................................................................. 38 6.0  HEAVY WATER AND LIGHT WATER MIXING ...................................................................... 39 6.1  Leakage of Light Water into the Heavy Water Reflector ....................................................... 39 6.2  Leakage of Heavy Water into the Light Water System .......................................................... 40 7.0  MAXIMUM HYPOTHETICAL ACCIDENT ............................................................................... 43


The loss of anterior teeth can be distressing for patients, both socially and psychologically. Conservative solutions for the restoration of a single edentulous space in the anterior maxilla and mandibula present an esthetic challenge to the clinician. In recent years, reinforcing resin–based fixed partial denture (FPD) frameworks have achieved increasing acceptance in prosthodontics as applicable alternatives to metal–based restorations. Chairside tooth replacement is an application of fiber reinforced restorations. Immediate chairside replacement of an anterior tooth may present to the patient's esthetic, comfort, treatment acceptance, expectancies of treatment and use when the patient needs a short– term solution. Several approaches have been described for the immediate replacement. This clinical report presents 3 cases where fiber reinforced artificial tooth was successfully used to provisionally restore anterior edentulous area in terms of esthetic–cosmetic values and functionality.


In April 2016, a group of asylum seekers collectively refused the food served at their new interim accommodation centre in Offenburg for several weeks. I found out about their protest via an article in the regional newspaper Mittelbadische Presse (9/4/2016). According to the article, the asylum seekers were collectively refusing food because they were discontent with their transferral from one of the emergency reception facilities to a new interim accommodation centre, a so-called "container village" on the outskirts of town, set up to accommodate the asylum seekers for up to two years. While the asylum seekers had been able to cook for themselves at their previous reception centre, the new one offered no such facilities. Instead, an external caterer provided food to the asylum seekers three times per day. At first glance, this protest resembled what I had witnessed at the emergency reception centre in BadWaldsee. In both cases, food served as an important means for asylum seekers to make themselves visible as claims-making subjects. The storying of events in Offenburg, however, turned out to differ strongly from the one in Bad Waldsee. While, in the latter, the protesters were recast as mute victims and passive recipients of help and support in the wake of their protests, this was clearly not the case in Offenburg,where the local district council recast the protesting asylum seekers as "bogus" asylum seekers or "economic migrants" who should be excluded from humanitarian protection, whose presence was deemed illegitimate and who were rendered deportable. And yet, this storying was highly contested by volunteers supporting refugees in town. In what follows, I scrutinize this contested storying by outlining how different actors responded to and made sense of the protests at the Offenburg container village. To start off, I illustrate how the district council deemed the protests illegitimate and stripped them of political meanings.


The development of the Industry Foundation Classes (IFC) started from the vision of an integrated building product model which would cover all necessary information for buildings' whole lifecycle: requirements management, different design activities and construction and maintenance processes. Although the IFC model specification covers a substantial part of the required information its implementations into practical applications have shown several serious problems. One of the main problems is that the internal structures of the different software products do not support the information needs for the whole process. Thus, the idea of lossless, incremental data flow through the different applications used by the project participants has not come true. It is obvious that file based data exchange is not feasible solution, and some other solution for integrated project data model is necessary for the AEC industry. This paper discusses some viewpoints and potential solutions to the above problem.


This paper mainly discusses uniform stability problems of a class of fractional-order neural networks with distributed delays. We obtain existence and uniqueness conditions of solutions and uniform stability results for this system by applying fractional calculus theory and Banach fixed point theorem.


As the research hotspot of restoring vision for retinitis pigmentosa and age-related macular degeneration, visual prosthesis can form the visual perception and restore vision by capturing image with a microcamera, processing and encoding, transmitting the signal to the neural stimulator and delivering the current pulse to the neural system. Generally, three major types of visual prostheses are currently being developed: stimulation of the visual cortex using cortical implants, retinal devices implanted in the subretina or epiretina, and stimulation of the optic nerve. This paper will introduce the current progress and future challenge of visual prosthesis by C-sight group.


Analysis of Exercise Intensity and Energy Expenditure of Women Participating in the Curves Exercise Program Gregory D. Farris, B.S.Ed., M.Ed. Committee Chairperson: Richard B. Kreider, Ph.D. The Curves program is designed to improve fitness. The purpose of this study was to identify exercise intensity, HR and energy expenditure in a group of women participating in the Curves program. Seventy-eight women (53.6 ± 7.09 yrs, 192.1 ± 30.43 pounds, 43.5 ± 4.52 % fat) performed the Curves workout on two occasions. Results show that mean HR was 119 ± 15 b/min which was equivalent to 79% max HR or 63 % HRR. Thirty-three women (52.7 ± 6.68 yrs, 193.1 ± 31.73 pounds, 1.8 ± 0.28 L/min VO2 max) performed the Curves 30-min workout on two occasions. Results show that the mean RER to perform the 30-min workout was 1.00 ± 0.07 and 0.98 ± 0.05 for the two sessions. Estimated caloric expenditure was 164.5 ± 25.19 kcals and 160.6 ± 28.36 kcals for the two sessions. Results indicate that the Curves program qualifies as moderate intensity exercise.


The advancement of the construction of the energy internet has put forward higher requirements for multi-heterogeneous energy dispatch and multi-source information processing. As the core of the energy Internet, integrated energy service station is both the integration center of data and the regulation center of energy, and needs to realize the functions of information integration and sharing, energy cooperative dispatching, etc. in addition to completing the function of power transformation. This paper takes into account the hardware and software characteristics of the hybrid external network communication environment, analyses the multiple communication modes of the integrated energy service station, proposes an information monitoring architecture and network model with the integrated energy service station as the hub based on the requirements of information type, transmission data size, communication delay and reliability, and gives concrete implementation examples.


A fluid flow benchmark exercise was conducted to compare results between a cellular automata code and FIDAP. Cellular automata codes are free from gridding constraints, and are generally used to model slow (Reynolds number {approx} 1) flows around complex solid obstacles. However, the accuracy of cellular automata codes at higher Reynolds numbers, where inertial terms are significant, is not well-documented. In order to validate the cellular automata code, two fluids problems were investigated. For both problems, flow was assumed to be laminar, two-dimensional, isothermal, incompressible and periodic. Results showed that the cellular automata code simulated the overall behavior of the flow field. 7 refs., 12 figs.


At the Barcelona Meeting in March 2002, the EU member-states agreed upon a common policy goal to increase expenditures for research and development to 3% of GDP by 2010. In 2005 this target was also adopted by the Norwegian Government. This thesis is a case study of how and why the 3% objective became a goal in Norwegian research and development (R&D) policy. The adoption of the EU target is considered a case of policy diffusion through Europeanisation. A combination of features from theories used in Science and Technology Studies and Political Science is employed to show how different approaches to innovation and diffusion can help explain policy transfer from the EU to the national level. Furthermore, the combination of theories is used to analyse different actors and arguments involved in the diffusion process. The arguments were divided into interest-based, idea-based, and rule-based claims according to the motivations and mechanisms underlying them. Concluding remarks drawn from the study indicate that the adoption of the 3% target into Norwegian R&D policy was indeed a result of policy diffusion. Furthermore, the case points out how the identification of actors' interest-based, idea-based, and rule-based arguments can be vital for understanding the process leading to the transfer of this EU policy goal. However, while the combination of theories of diffusion and innovation are useful for explaining the Norwegian adoption of the 3% objective, its explanatory power is substantially reduced when trying to assess the implementation, or lack of implementation of this R&D policy goal.


We have used both Clontech AtlasTM Human Hematology/Immunology cDNA microarrays, containing 588 genes, and Affymetrix oligonucleotide U95Av2 human array complementary to more than 12,500 genes to get a global view of genes expressed in Epstein‐Barr virus (EBV)‐transformed B cells and genes regulated by Bruton's tyrosine kinase (Btk). We compared EBV‐transformed wild‐type (WT) B cells from a healthy individual, WT1 and an X‐linked agammaglobulinemia (XLA) patient cell line, XLA1, using the Clontech filters arrays. Eleven genes were ≥1.9‐fold induced in absence of functional Btk. Furthermore, we analyzed a second patient cell line, XLA2, and compared this to two WT cell lines using oligonucleotide arrays. A total of 391 genes were found to be differentially expressed, including kinases and transcriptions factors. Furthermore, one expressed sequence tag and eight complementary DNA clones with unknown function were down‐regulated in XLA2, indicating their biological role. Higher‐fold inductions, Fyn (39.5), Hck (15.5) and Cyp1B1 (5.8), were observed using oligonucleotide array and were confirmed using real‐time PCR for Fyn (20.8), Hck (6.7) and Cyp1B1 (10). Two genes, B cell translocation gene1 (BTG1) and B cell‐specific OCT binding factor‐1 (OBF‐1) were induced ≥1.9‐fold in both XLA1 and XLA2 analyzed by AtlasTM filter arrays andAffymetrix chips, respectively. Data from both filter and oligonucleotide arrays were compared to the gene clusters of a previously published lymphoma expression profile by linking to the UniGene transcript database. Our findings demonstrate for the first time the use of microarray to study the influence of Btk mutations and the use of functional annotation and validation of expression data by comparison of microarray analyses.


The effects of vanadate (Na3VO4) on endocochlear DC potential (EP) and cochlear microphonics (CM) were studied at the basal turn of guinea pig cochlea and its distribution in the cochlea was observed with an electron probe microanalyzer (EPMA). The results obtained were as follows;1. With perfusion of vanadate solution from the scala tympani, EP showed a transient overshoot and then a gradual decrease.2. With the perfusion from scala vestibuli, EP showed a rapid decrease without an overshoot. The decrease of EP was time and dose dependent of vanadate perfusion.3. With anoxic anoxia, negative EP was recognized and its negative potential level was decreased by longer perfusion.4. Cochlear microphonic potentials showed a decrease in parallel with the decrease of EP.5. By the histolagical study with EPMA, abundant accumulation of vanadate was recognized at the stria vascularis and also at the Corti's organ.6. From the results obtained, it is concluded that vanadate inhibits the electrogenic pump at the stria vascularis and also inhibits the hair cells of Corti's organ.


Electron microprobe analysis gave Na2O 4.45, K2O 0.07, CaO 14.77, SrO 18.19, BaO 0.10, La2O3 8.12, Ce2O3 13.14, Pr2O3 1.13, Nd2O3 3.81, Sm2O3 0.34, Y2O3 0.02, ThO2 0.02, SiO2 0.74, P2O5 30.71, F 2.03, H2O (calc) 0.38, O [ F 0.85, sum 97.18 wt%, corresponding to (Na1.93K0.02)S1.95(Ca3.54Sr2.36Ba0.01)S5.91(Ce1.08La0.67 2Nd0.30 Pr0.09 Sm0.03)S2.17 (P5.81 Si0.17)S5.98 O24[ F1.44 (OH).56]S2.00, ideally NaCa2 SrCe(PO4)3F. The mineral occurs as grains, up to 1.5 mm in size, that are intimately intergrown with belovite and an apatite-like mineral rich in Sr and REE. Bright yellow color, transparent, vitreous luster, white streak, brittle, step-like fracture, H 5 5, {1010} and {0001} cleavages, Dmeas 5 3.92(5), Dcalc 5 3.95 g/cm3 for Z 5 2. Optically uniaxial negative, e 5 1.660(2), v 5 1.682(2). Readily soluble in 10% HCl or HNO3 at room temperature. Strongest absorption bands in the infrared spectrum are at 1164, 1098, 1047, 1010, and 949 cm21, and weaker bands are at 600, 575, and 547 cm 21. Single-crystal X-ray structure study (R 5 0.049) indicated trigonal symmetry, space group P3, a 5 9.51(1), c 5 7.01(1) Å . Strongest lines of the X-ray powder pattern (57.3 mm camera, FeKa radiation) are 3.51(30,002), 3.12(40,210), 2.84(100 broad,211,112), 2.753(40,300), 1.967(30,222), and 1.870(30,213). The mineral occurs in hyperagpaitic pegmatites at the Khibina alkaline massif, Kola Peninsula, Russia. The new name is for Russian mathematician B.N. Delone (Delaunay), 1890–1980. Type material is in the Fersman Mineralogical Museum, Moscow. The mineral is chemically the Ca analog of belovite, but the two minerals differ structurally. J.L.J.


Soliton solutions of Einstein's field equations for space–times with two non-null,
commuting Killing Vectors are exact solutions obtained using the solution-generating
techniques that resemble the well-known Inverse Scattering Methods that have been
widely used m the solution of certain nonlinear PDE's such as Korteweg–de Vries,
Sine–Gordon, non-linear Schrodinger.
There exist two main soliton techniques in General Relativity. The Belinski–Zakharov
technique allows for purely gravitational solutions. The Alekseev technique
allows for solutions of the Einstein–Maxwell equations. In both techniques,
solitons arise in connection with the poles of a certain so-called "dressing matrix". [Continues.]


In this paper,a kind of limestone compound active agent(LCAA),which can greatly increase the strength of blended limestone cement was introduced.For example,52.5 MPa clinker can generate 42.5 MPa cement containing 30% limestones by mass when LCAA was used in the cement.Simultaneously,LCAA also had good effects on the strength increment of limestone mineral admixture concrete.Moreover,the shrinkage property of concrete was obviously decreased by adding lime stone admixture.Therefore,limestone had good future as mineral admixture in cement and concrete.


Wood vinegar( WV) is an important plant growth regulator-like substance used in agriculture worldwide,but little known on its mechanism at molecular level restricted its wider and further application. In this study,the effects of WV and auxin on the growth of Arabidopsis thaliana were compared at both genetic and morphologic level through semiquantitative PCR( SQ-PCR) and condition-controlled culturing. The results showed that WV can regulate auxin-inducible genes like Aux /IAA1,Aux /IAA5,Aux /IAA19,ARF19 and SAUR-AC1 expression. Through interaction between Aux /IAAs and ARFs,WV had a negative feedback in its regulation pathway,similar to the homolog of auxin IAA's. In addition,the morphologic comparison results showed that WV and auxin IAA both repressed leaf number and its expansion but promoted main root elongation and lateral root formation. These results indicated that the regulation effect of WV was similar but not identical to that of auxin. The results presented in this study will contribute to the wider and more precise usage of WV in agriculture.


This study examined the relationship between lean management and operational performance with the mediating
effect of human resource management (HRM) practices in Malaysia local authorities. Participants reported their perceptions of lean management implementation (philosophy, process, people and partners, and problem solving), resultant operational performance (efficiency and effectiveness), and four dimensions of HRM practices: selection and hiring, training and development, performance evaluation, and rewards and incentives. The evaluation of structural model of Partial Least Square- Structural Equation Modeling (PLS-SEM) using SmartPLS3 showed the superiority of the models in which: (1) philosophy significantly and positively affected effectiveness performance, (2) rewards and incentives significantly affected both efficiency and effectiveness performances, (3) philosophy significantly and positively affected all the four dimensions of HRM practices,
and (4) rewards and incentives mediate the relationship between philosophy and both efficiency and effectiveness performance. The implications of these results are discussed, especially regarding the effect of philosophy on operational performance in organization.


According to the epistemic view, vagueness is a case of ignorance. Neither do we know of any given borderline statement that it is true, nor do we know of any such statement that it is false. We are ignorant of which truth-value any given borderline statement has. Some proponents of the epistemic viewthe epistemicists hold that we nonetheless know that there is something we thus are ignorant of: we know that borderline statements are either true or false, although we do not know which truth-value they have. If all borderline statements are either true or false, as epistemicists contend, then vague terms have sharp boundaries. Accordingly, epistemicists claim that we do know that vague terms have sharp boundaries, although we do not know where they lie. That vague terms have sharp boundaries follows from the application, to statements in which these terms occur, of classical logic and its attendant bivalent semantics. Epistemicism thus incorporates classicism as applied to vague discourse. Others who still think that vagueness is at bottom an epistemic phenomenon, object to the epistemicist claim that we know that borderline statements are either true or false. According to these thinkers, we are not only ignorant of which of the two truth-values, if any, borderline statements possess, we are also ignorant of whether they have a truthvalue which we thus are ignorant of. To hold such a view implies commitment to the claim that epistemicism has not been shown to be correct. Thus, it would appear that proponents of this view are obliged to counter epistemicist arguments for applying the principle of Bivalence to borderline statements. However, epistemicists typically do not produce any such arguments, but rather take the validity of classical logic and the adequacy of its bivalent semantics for granted. Thus, epistemicists conceive of their position as leaving room for what is considered to be an independently motivated logical theory to which no serious alternative has been proposed. They try to show that the phenomenon of


A run-mode system allows itself to be changed while in operation, as opposed to systems that must be shut down for modification. A run-mode system is in a dynamic state when it is in transition from one static state to another. This research examines the correctness of run-mode systems in both static and dynamic states. As run-mode systems have many practical areas of application, this research uses the Petri net as the abstract model for developing the basic concepts and algorithms for correctness checking.
The traditional correctness checking problem of Petri nets examines a net's internal mechanism and it has been proved to be undecidable. This research proposes a new interpretation that focuses on the properties of the outcomes generated by a net. A path property notion is introduced in this dissertation for describing the characteristics of an outcome. The correctness checking evaluates a net's final path property against a specified correctness criterion. A net-wide checking algorithm is applicable for both static and dynamic checkings. To make the correctness analysis technique a more reasonable method with practical applicability, a change decomposition strategy, an elementary changes analysis, and a regional analysis are incorporated with the net-wide checking algorithm. The resulting integrated analysis technique provides a feasible and useful solution for both static and dynamic correctness checkings on run-mode systems. Its feasibility is demonstrated by an operational prototype system.
The research described in this dissertation produces at least three notable contributions. First, it offers a new interpretation focusing on the properties of the outcomes. The correctness checking problem is no longer undecidable as under the traditional interpretation. Second, it provides an integrated method to solve the correctness checking problem, in both static and dynamic aspects. Third, it provides analysis techniques to reduce the scope and degree of checking operations. An integrated checking method can be incorporated in practical applications. The first two are techniques provided by the research results. The third one is a goal; it can be reached by developing more ideas and techniques based on the foundation built by the first two techniques.


Abstract The reactions of cyclotriphosphazene (1) with 2-(2-hydroxyethylamino)-ethanol (2) were investigated. 2-(2-hydroxyethylamino)-ethanol (2) is a tri-functional reagent consisting of both aliphatic hydroxyl and the secondary amino groups and its nucleophilic substitution reactions with cylotriphosphazene can lead to different product types; open chain, spiro, ansa, bridged and their mixtures. The reactions with one, two and three equimolar ratios of 2-(2-hydroxyethylamino)-ethanol, in the presence of NaH at 0–10 °C and at room temperature gave the following cyclotriphosphazene derivatives: one mono-spiro, N3P3Cl4[O–(CH2)2–NH–(CH2)2–O] (3, 1:1, r.t.); its isomer mono-ansa (5, 1:1, r.t.); one dispiro, N3P3Cl2[O–(CH2)2–NH–(CH2)2–O]2 (4, 1:1, r.t.); its isomer spiro-ansa (6, 1:2, r.t.); and one single-bridged compound with spiro substituted units, N3P3Cl3[O–(CH2)2–NH–(CH2)2–O]3N3P3Cl3 (7, 1:3, at 0–10 °C); as well as single-, N3P3Cl5[O–(CH2)2–NH–(CH2)2–O]N3P3Cl5 (8, 1:2, r.t.), double-, N3P3Cl4[O–(CH2)2–NH–(CH2)2–O]2N3P3Cl4 (9, 1:2, r.t.), and tri-bridged, N3P3Cl3[O–(CH2)2–NH–(CH2)2–O]3N3P3Cl3 (10, 1:3, at 0–10 °C) derivatives. Triple-bridged derivative is the major product in this system. The structures of the novel-derived compounds were characterized by TLC-MS, FT-IR, elemental analysis, 1H, and 31P NMR spectral. Graphical Abstract


The invention relates to compounds SEEM TO HUMAN MILK FAT. THESE COMPOUNDS COMPRISING TRIGLYCERIDES IN WHICH AT LEAST 40% OF THE TOTAL AMOUNT OF WASTE OF FATTY ACID THIS SATURATED IN THE TRIGLYCERIDES ARE UNITED IN THE SECOND POSITION, WHILE THE WASTE OF FATTY ACID IN THE FIRST AND THIRD POSITIONS ARE DISTRIBUTED DISORDERLY OR NOT haphazardly between these positions AND INCLUDE Oleic acid, linoleic and linolenic WASTE AND OTHER UNSATURATED. The invention further relates to a fatty REPLACED MILK, A CHILD AND SUPPLY PROCESSES FOR THE PREPARATION OF COMPOUNDS.


In this paper, we discuss how access to health-related data by private insurers, other than affecting the interests of prospective policy-holders, can also influence their propensity to make personal data available for research purposes. We take the case of national precision medicine initiatives as an illustrative example of this possible tendency. Precision medicine pools together unprecedented amounts of genetic as well as phenotypic data. The possibility that private insurers could claim access to such rapidly accumulating biomedical Big Data or to health-related information derived from it would discourage people from enrolling in precision medicine studies. Should that be the case, the economic value of personal data for the insurance industry would end up affecting the public value of data as a scientific resource. In what follows we articulate three principles – trustworthiness, openness and evidence – to address this problem and tame its potentially harmful effects on the development of precision medicine and, more generally, on the advancement of medical science.


Objective
To explore the application of penile base staggered flap in the operation of severe hypospadias with penoscrotal transposition.

Methods
Twenty-three cases with severe hypospadias with penoscrotal transposition were corrected by urethroplasty and staggered flap plasty in our department from May 2013 to June 2016. After urethroplasty, the skin at the junction of the penile base and scrotum was transversely cut by 1.5-2.0 cm, and then sutured with Z-plasty to reconstruct the angle of the penis and scrotum.

Results
After the operation, infection and cracking at the suture of the staggered flap occurred in one child and was cured after dressing change and symptomatic treatment. Two cases suffered from urine leakage at the suture of the staggered flap. One of the cases realized self-healing and the other received a repair operation for urinary fistula. Three children suffered coronary sulcus fistula and was cured by urethroplasty. All the patients were followed up from 10 to 30 months with normal penis scrotal position and satisfactory appearance.

Conclusions
The application of penile base staggered flap can be used for severe hypospadias in one stage with penoscrotal transposition surgery. It is a simple and satisfactory method for the treatment of hypospadias with penoscrotal transposition.

Key words:
Hypospadias; Penoscrotal transposition; Urethroplasty; Surgical flap


Michigan Central Station and Roosevelt Park were constructed between 1908 and 1918 as part of Detroit's City Beautiful Movement. The construction process was a place-making effort designed to implant order on the urban landscape that involved the displacement of a community who represented everything that city planners sought to erase from Detroit's city center: overcrowding, poverty, immigrants, and transient populations. Current historical archaeological research reveals how the existing ornamental landscape of Roosevelt Park masks the history of a forgotten working-class neighborhood. This synthesis of archival and material evidence details the conditions of life within the neighborhood and of a contentious, decade-long displacement struggle rooted in the inequalities of early-20th-century industrial capitalism. Positioned at the start of a century of controversial urban planning initiatives, the Roosevelt Park case study encourages understandings of displacement as a process that has diachronic and comparative dimensions, both in Detroit and in other urban settings.


An apparatus for treating surface of base plate, which features that the performance of its treating liquid can be held up after the treating liquid is cyclically used, is composed of treating unit to be able to sequentially deliver the treating liquid and flushing liquid to the base plate on treating table; recovering unit for recovering waste treating liquid and flushing liquid; the waste liquid staying, concentration testing and liquid supplementing unit for testing the concentration of waste treating liquid and regulating it; and the treating liquid supplementing unit for providing the regulated treating liquid to said treating unit.


Background/Aim: Refractive errors are abnormal visual conditions that are usually managed by spectacle correction, use of contact lenses or laser surgery. They are relatively common and should be corrected as soon as possible in children to enable them have adequate vision to live a normal active life without visually-induced limitations. With increasing westernization, the misconceptions illiterate and semi-literate parents had about use of glasses at an early age have been largely overcome and more young children are nowadays being brought to the hospital for visual problems and where refractive errors are implicated, having their parents actually purchase the spectacles and encourage their use. The aim of this study is to find out the types of refractive error that occur in children aged 1 18 years obtaining spectacle correction from the Nigerian National Petroleum Corporation (N.N.P.C.) Medical Services in Akpajo, Port Harcourt. This is for comparison with data obtained in other locations within the state, geographical region and worldwide for effective planning for future school health and prevention of blindness programmes in the state. Methodology: This is a retrospective study in which data on refraction was obtained from the records of all children (aged 1 18 years) who were refracted during a period of one year (1st May, 2018 to 30th April, 2019) at the NNPC medical services facility. The children entitled to treatment in this facility are those of currently serving staff of the corporation. Relevant data such as age, sex and past ocular/family history were obtained from the electronic medical records. Other data included visual acuity, results of basic eye examinations; external ocular examination, funduscopy, slit lamp examination as well as the result of refraction. All the information was entered into a proforma specifically designed for this study and analysis was done using SPSS Version 20. Results: One hundred and fifty one children were seen, sixty six males and eighty five females with an age range of 1 18 years. (mean age was 12.53 std = 3.18. The commonest refractive error encountered was hyperopic astigmatism, followed closely by myopic astigmatism. Hyperopia was uncommon and anisometropia was rare. Refractive error is commonest in the adolescent age group (13 18 years) and there is no significant relationship between type of refractive error and sex distribution of patients diagnosed with refractive error.


External cephalic version (ECV) is an effective and safe technique for avoiding breech presentation at birth. However, it continues rejected by many women. The aim of this study is to develop a predictive model of success of external cephalic version, determine the safety of the technique and perinatal outcomes after successful version.


In this study, were compared the photosynthetic performance of chlorophyll b (Chl b)-deficient mutant lines (ANK-32A and ANK-32B) and wild type (WT) of spring wheat (Triticum aestivum L.) grown under sun and shade light regimes, at fourth fully developed leaf, grown in pots under natural climatic conditions. Analyses were based on measurements of pigment composition and fast chlorophyll (Chl) a fluorescence kinetics. The content of Chl a+b sun (WT 372, ANK-32A 144 and ANK-32B 128 mg*m-2) versus shade (WT 293, ANK-32A 150 and ANK-32B 151 mg*m-2) was statistically significant and the difference between WT and mutant ANK. Unlike the sun-grown, shade grown plants of ANK mutants did not express a severe chlorina phenotype.


This paper aims to dispute the following themas. ① the heads of non-pecuniary loss, ② the meaning and function of damages for non-pecuniary loss, ③ the conditions of entitlement as to damages for non-pecuniary loss, ④ the unconscious victim"s entitlement to damages for non-pecuniary loss. after comparative analysis, I have drawn the following conclusions. first, non-pecuniary loss is defined as an attack on one"s physical integrity which has no effect on one"s patrimony and is usually broken down into "pain and suffering" and 'loss of amenity(the injury itself and its impact on the plaintiff"s enjoyment of life)'. unconscious victim is entitle to substantial damages for non-pecuniary loss(loss of amenity). secondly, the meaning of damages for non-pecuniary loss is to provide solace for the real hurt suffered by the victim of a tort, to affirm human dignity and to confirm that personal capacities and mental equilibrium affect the quality of our life as human beings. thirdly, deterrence play much important role in damages for non-pecuniary loss than in damages for pecuniary loss because the conduct can increase the grievance of the victim. but judge should maintain limit of "real cost" in award damages for non-pecuniary loss. because the law of tort is not to prevention and punish but to compensate, and deterence and punishment is the only side effects. fourthly, in order to embrace every type of torts, we need flexile rule. so korean civil code art. 750 should be applied to cases that is not embraced by korean civil code artt. 751-752.


The principal value of specialized audiologic techniques lies in early diagnosis of retrocochlear lesions, which in turn minimizes technical difficulties in the surgical removal of acoustic neuromas; however, despite a wide battery of audiometric tests, the otolaryngologist too often has difficulty in distinguishing between cochlear and retrocochlear lesions. Johnson1 observed deviations in one or more respects from the classic audiometric findings in almost half of the cases of acoustic neuroma that he studied. Other audiologists2 have encountered similar problems.


The Ad Hoc network has a high demand for real-time data transmission, and TDMA algorithm plays an important significance in reducing delay. In this paper, we propose an adaptive timeslot exchange dynamic TDMA timeslot allocation algorithm in consideration of the relationship between data stream and timeslots. The exchange frames are added to the super frame, and the master timeslot adaptive switching technology is used to reorder the sequence allocation of the data streams. At the same time, defining the value of the data flow and optimizing the timeslot allocation sequence of the entire network data flow. Finally, distributing exchanging timeslots makes the sequence of network data streams in the time-sequence order consistent, which reduces the scheduling delay of the traditional timeslot allocation algorithm. Simulation results show that the average delay of the proposed algorithm is reduced by 33.41% after 6 hop counts while the average utilization of timeslots has an increase of 27.05% compared with P-TDMA algorithm.


The progress of nations has developed since the industrial revolution, which generated an impact on the creation of factories, the same thing happened with the world wars, which caused many deaths due to the deployment in the creation of war weapons. Reason for which labor accidents increased strongly within the factories and this is how industrial safety appears in the labor field with the purpose of reducing work accidents. Companies invest large amounts of money in staff training, to ensure the welfare of their employees. The present investigation analyzes this important aspect and it is included in the educational area because resources are used within the professional practice using laboratories and industrial workshops. The Tomas Oleas Educational Unit of the Colta Canton, forms technical baccalaureates that use laboratories daily and seeks to generate a safe environment. A diagnosis of the current situation was planned and executed, determining the requirement for Industrial Safety signage. For its implementation, signs were used in the following aspects: Obligation, Prevention, Prohibition and Evacuation; complying with established standards and technical specifications. With this investigation information of the current state of the workshop was collected, in addition, it was made directly where the facts occur, that is to say in the aforementioned institution, in conclusion the signage and industrial safety were implemented properly. Workshop personnel are recommended to keep the aforementioned indications, observe and comply with the rules established to safeguard their integrity.


Abstract This article presents a consideration regarding semiosis and the theoretical problems faced in semiotics in cases where the approach to the phenomenon is taken under limiting conditions such as a singular focus on subjects or objects in semiosis. These problems, exemplified as disjointed components of the Tartu-Moscow school can be faced and overcome given a complex approach as the paradigm established by the combination of parts given in Tartu-Moscow semiotics through its heritage of complex subject-system relations in the semiosphere. The implications of this thought are considered as a potential solution to the issues of limiting semiosis to either a singular or dual reference of signification, creating a coherent tool for the analysis of semiosis beyond the vague definition of the action of signs.


The spatially explicit and mechanistic model TREEGRASS was used to test the effects of tree density, tree spatial distribution, and tree size distribution on radiation absorption, net primary production (NPP), and water fluxes for a West African savanna. The model has previously been shown to adequately predict radiation absorption, production, and soil water balance in humid savannas. Using field measurements quantifying the spatial variations in grass NPP, the model was found to predict correctly the effect of tree abundance on grass NPP. Model simulations showed that annual photosynthetically active radiation (PAR), absorption efficiency, NPP, and transpiration of the tree layer increased with increasing tree density and decreased with increasing tree aggregation; the grass layer showed the opposite trends. Total NPP (tree plus grass) remained stable for all tree densities and decreased slightly for aggregated tree distributions. Total transpiration increased with tree density and was not affected by t...


In this study, seven water stress tolerant wheat genotypes including two exotic viz., Nesser and Dharwar dry and five local verities viz. GA-2002 Bakhar-2002, Chakwal and Inqulab-91 and Kolhistan-97 were crossed with university drought susceptible lines viz. 9244, 9247, 9252, 9258, 9267, 9316 and 9021 by using line x tester mating design. The objective of the study was to evaluate the effect of water stress on physioco-chemical properties of wheat grains. Moisture, ash, fat, protein, gluten, Zeleny, thousand kernel weight and grain yield values showed different response under normal and water stress environments. The quality traits of wheat grain were significantly affected under water stress conditions. The moisture content decreased while other constituents, predominantly protein contents increased in the entire cross breeds under water stress conditions. The protein showed positive correlations with dry gluten and Zeleny values while negative correlation with ash content of grain under normal and stress conditions The protein contents, gluten quality and contents have significantly negative correlations with grain yield and thousand kernel weights under stress condition, so it is imperative for breeders to balance these characters through genetic manipulation.


Objective To investigate related factors of deliration after TUPKVP and method of treatment,in order to raise the level of treatment in these patients.Methods 212 cases patients with benign prostatic hyperplasia(BPH)were given TUPKVP,analyzed related factors of patients with deliration.Results 11 cases patients occurred postoperative deliration,all were elderly patients,mainly for the perceived problems,memory loss,orientation less and so on.Conclusion The main reasons of postoperative deliration were elderly,knowledge and ability in patients with damage to sensory.The key of preventing and treating the complications was to strengthening of preoperative,intraoperative and postoperative management.


The paper reviews the coordination and interaction of the many disciplines that are required for the development of a commercially viable fuel cell system for transportation. Fluid dynamics, mechanical engineering, and control systems skills are required to develop an optimized system, and the interaction of the vehicle with the fueling infrastructure adds further to the overall complexity of the technology. Examined are proton exchange membrane fuel cells, and hybridization/optimization of two different power plants for transportation use.


Abstract Whilst health consequences of being locked-in at the workplace have been documented in several research studies, it is largely unknown how work characteristics and their changes over time relate to risks for becoming locked-in at a certain workplace. Accordingly, this paper studied how perceived control, learning opportunities and quantitative demands at work associate with workplace-locked-in (WPLI). The study included permanent employees who participated in the Swedish Longitudinal Occupational Survey of Health (SLOSH) study in wave 3 through 5 (n = 2918 individuals; n = 7460 observations). Results from multi-level analysis show that there was significant individual variation in WPLI changes over time, even though on average, WPLI decreased slightly. Differences in work characteristics between individuals (L2) and across time (L1) associated significantly with WPLI: higher levels of job control and learning opportunities related to lower odds ratios for WPLI, whereas higher quantitative job demands associated with higher odds ratios of WPLI. Moreover, differences in quantitative job demands, number of job changes and educational achievements explained the individual variations of WPLI developments over time. The result shows that WPLI can – to some extent – be prevented or reduced through good work design, and implications for HR managers and organizations are discussed.


Responses to salt stress were investigated in three alfalfa varieties (Gabes, Hunterfield, and Hyb.555). Seedlings were submitted to salinity induced by adding NaCl into water at 4 concentrations (0 2.5 5 and 10g.l). Growth parameters (DM, plant height, LA, LAR, SLA, leaves thickness, succulence), and hydraulic parameters (RWC, WC, WUE) were investigated in leaves, stems and roots after three months of salt stress. Results showed that NaCl decreased DMY of the three varieties. However, Gabes variety, compared to Hunterfield and Hyb.555 has a DMY significantly higher, in the absence and presence of NaCl. The severe decrease in the DMY of the introduced varieties was related to the premature senescence accelerated by the salt intensity and the duration. On the other hand, Gabes variety has a well-equilibrated distribution of DM between organs. The LAR and the SLA decreased significantly with the salt increasing. The salt increased the leaves thickness and succulence. WC increased in concomitance with the rise of leaf succulence. WUE under salt stress decreased in the three lucernes. However, Gabes variety has WUE significantly higher in all salt treatments. This study allowed highlighting the interest of the Gabes variety in any selection program for salt tolerance.


Natural cells have become an area of interest due to their biocompatibility, non-immunogenicity, biodegradability, and targeting specificity. The human vascular system retains distinctive physiological features that can be developed for enhanced and effective targeted drug delivery. Red blood cells (RBCs) have unique features and properties that make them potential natural carriers for numerous substances. Recently, the RBC membrane has become a unique biological carrier and it has been extensively studied due to its long-circulating half-life, low toxicity, high stability and the ability to transport various biologically active substances with higher drug release efficiency. Among the benefits of the RBC membrane as a drug delivery carrier in medical and biological fields is the use of this system in anticancer therapy. Antitumor drugs are loaded in gold NP, magnetic NPs, or mesoporous silica NPs. Then, the loaded NP is used as a core and coated with an RBC membrane to protect the NP from immune attack and enhance drug targeting. Moreover, RBCs have been used for encapsulating different enzymes to overcome the undesirable outcomes associated with enzyme replacement therapy. This review highlighted the most recent RBC membrane preparation methods, such as Membrane coating technology and Osmotic Loading Procedures. The recent advances in the design of RBC membrane carriers and discuss the applications of RBCs in different fields such as therapeutic enzymes, immunotherapy and anti-tumour therapy. Given the potential risks and challenges in the development of any treatment protocol, this review elucidated the problematic aspects and prospects, describing new modalities to overcome these problems. RBCs as a drug carriers are among the most interesting topics as a novel drug delivery system as they are convenient, effective, safer, biocompatible and have good properties to deliver and administrate the drug specifically to the target site of action with fewer side effects and interference with therapeutic aspects.


Calf milk replacers (CMRs) provide a convenient way to feed pre-ruminant calves. They can be stored long term as powder and mixed with water just prior to feeding. Calves can then be milk reared anywhere and at any time without having to source liquid whole milk. Provided the CMR is formulated correctly from good-quality ingredients and fed according to the instructions, which are usually on the CMR bag, calves can grow equally well when reared on CMR and their rumens can develop just as well as they would on a diet of whole milk. Because manufacturing CMR directly from whole milk is an expensive process, and because whole milk has a high market value, the bulk of the ingredients for commercial CMR are either by-products of dairy processing or non-dairy products. Obviously, the This chapter discusses the considerations to make when deciding on a calf milk replacer (CMR) feeding program.


PURPOSE: A liquid crystal alignment layer composition, an alignment layer manufactured thereby, a manufacturing method of the alignment layer, an optical film, and a display device including the display device are provided to secure the excellent vertical alignment property to a liquid crystal. CONSTITUTION: A liquid crystal alignment layer composition contains 1~50wt% of photo-curable resin binder; 0.01~5wt% of amine compound selected from the group consisting of first and second coupling agents; 0.1~5wt% of photoinitiator; and the balance of solvent. A manufacturing method of a liquid crystal alignment layer comprises the following steps: coating the liquid crystal alignment layer composition on a substrate; removing the solvent from the liquid crystal alignment layer composition; and curing the liquid crystal alignment layer composition.


ObjectiveTo observe the effects of cigarette smoke and green tea on radiation-induced bone marrow cell mutation, and to provide scientific information for prevention and treatment of radiation damage. Methods There were 8 groups in the factorial experiment design with 3 factors at 2 levels. Mice were randomly divided into each group. There were 8 mice in each group. Mice in seven experimental groups were exposed to cigarette smoke, green tea, radiation or their mixtures respectively. One group was treated as the blank control group. The frequencies of micrnucleated polychromatic erythrocytes (MPCE) were scored by single blinded method. The data were analyzed with factorial experiment's analysis of variance using SAS 8.0. Results Analysis of variance showed that radiaton, cigarette smoke and green tea were independently significant factors (P0.01). Interactions between cigarette smoke and radiation or between green tea and radiation were statistically significant (P0.01). ConclusionRadiaton and cigarette smoke can cause bone marrow cell mutations independently. There is synergistic effect between cigarette smoke and radiation. Green tea can inhibit radiation-induced cell mutation.


In this paper, we demonstrate the existence of some fixed points of rational type contraction in context of S-metric space and we examine the T-stability of the P-property for some mapping. Also, we present few examples to illustrate the validity of the results obtained in the paper.


Let $A$ be a commutative and unital $\mathbb{R}$-algebra, and $M$ be an Archimedean quadratic module of $A$. We define a submultiplicative seminorm $\|\cdot\|_M$ on $A$, associated with $M$. We show that the closure of $M$ with respect to $\|\cdot\|_M$-topology is equal to the closure of $M$ with respect to the finest locally convex topology on $A$. We also compute the closure of any cone in $\|\cdot\|_M$-topology. Then we omit the Archimedean condition and show that there still exists a lmc topology associated to $M$, pursuing the same properties.