A novel catalytic alkylation of indoles with allylic alcohols has been developed. Catalyzed by sulfuric acid (10 mol-%), the reaction between indoles 2 and allylic alcohols 1 based on ketene dithioacetal affords polyfunctionalized indoles 3 in good to excellent yields with high regioselectivities under mild conditions. The catalytic carbon-carbon coupling reaction provides a facile method for the environmentally benign functionalization of indoles with the advantages of good regiochemistry, atom efficiency, easily available catalyst, good yields and the synthetic potential of the polyfunctionalized indole products. Thus, further transformation of the resulting indoles 3 into pyridoindolone derivatives 4 was investigated. The efficiency of this carbon-carbon coupling reaction of 1 with 2 under the catalysis of sulfuric acid is due to the efficient formation of the reactive intermediate I, which is a carbocation that is strongly stabilized by two alkylthio groups at the terminal of the carbon-carbon double bond. The extension of this catalytic strategy to the synthesis of β-naphthols 5 was also achieved.


Mycorrhiza is a mutualistic symbiotic relationship between the root system of higher plants and fungal hyphae. The fungal network increases the capacity of plant to absorb more water and nutrients. This process helps in growth and favours rapid development of roots and plants. Arbuscular mycorrhiza (AM) is the most ancient type of mycorrhizal association between land plants and fungi of the phylum Glomeromycota (Tapadar et al., 2016b; Schüßler et al., 2001). AM fungi colonize the terrestrial plants of most ecosystem and forms functional links between soil and plants (Smith and Read, 2008). They facilitate inter plant transfer of nutrients, modify plant water relations and thereby improve stability of plant community (Smith and Read, 1997). It also plays an important role in stability of soil structure and water retention by the production of sticky International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 7 (2017) pp. 4501-4511 Journal homepage: http://www.ijcmas.com


The component glycerides of camel (Camelus indicus) depot fat were fractionated by crystallization of the neutral fat from acetone and ether and the composition of the fractions obtained was determined after ester fractionation. The major component acids are palmitic, stearic and oleic acid, with smaller amounts of myristic and hexadecenoic acid, and minor proportions of tetradecenoic acid. The chief component glycerides are—(i) 20.9% of fully saturated (dipalmitostearin and monopalmitodistearin); (ii) 61.6% of mono-unsaturated-disaturated (hexadecendopalmitostearin, oleopalmitostearin and oleodipalmitin); (iii) 17.5% of di-unsaturated-monosaturated (hexadeceno-oleopalmitin, dioleomonopalmitin and dioleomonostearin). The glyceride structure follows the typical land-animal fat type, i.e. 'random' distribution. The fully saturated glyceride content of the fat, determined separately by method of Hilditch & Lea, is 21.7%.


The present study aimed to detect the mutation characteristics of mitochondrial DNA (mtDNA) in Eca109 of Ec9706 cells, and to investigate their association with the nuclear genome (nDNA), thus providing a basis for gene targeting therapies for esophageal squamous cell carcinoma (ESCC). In vitro-cultured Ec9706 and Eca109 cells were analyzed the changes of single-nucleotide polymorphisms (SNPs), insertions/deletions (INDELs), copy number variation, and structure variation (SV) of their genome by high-throughput sequencing. The loci with SV on chromosome 1–12 of the two ESCC cell lines were ≥5% of the mtDNA, but SV on chromosome 13–22, X and Y was ≤3%; >40% of loci exhibited gain or loss; intergenic loci with INDEL changes and SNP features accounted for the majority of mutations. The affected genes encoded proteins including nDNA-encoding intra-mitochondrial-transporting proteins, ATP energy generation-associated proteins and mitochondrial electron respiratory chain proteins, and these proteins were all nucleus-encoded mitochondrial proteins. The transcription, duplication, and translation of the abnormally expressed mtDNA in Ec9706 and Eca109 cells were closely associated with disorders of nuclear DNA products.


Throughout this paper X is a Banach space and $\mu$ is the Lebesgue measure on [0, 1] and all operators are assumed to be bounded and linear. $L^1(\mu)$ is the Banach space of all (classes of) Lebesgue integrable functions on [0, 1] with its usual norm. Let $T : L^1(\mu) \to X$ be an operator.


The performance of an entire ship is increasingly impacted by propellers, which are the essential components of a ship's propulsion system that have growing significance in a variety of aspects. Consequently, it has been a hot research topic and a challenge to develop high-performance antifouling and anti-cavitation coatings due to the issue of marine biofouling and cavitation faced by propellers in high-intensity service. While there is an overwhelming number of publications on antifouling and anti-cavitation coatings, a limited number of papers focus on integrated protective coatings on propellers. In this paper, we evaluated the development of antifouling and anti-cavitation coatings for ship propellers in the marine environment as well as their current status of research. These coatings include self-polishing antifouling coatings, fouling-releasing antifouling coatings, and biomimetic antifouling coatings for static seawater anti-biofouling, as well as anti-cavitation organic coatings and anti-cavitation inorganic coatings for dynamic seawater anti-cavitation. This review also focuses both on the domestic and international research progress status of integrated antifouling and anti-cavitation coatings for propellers. It also provides research directions for the future development of integrated antifouling and anti-cavitation coatings on propellers.


Modern education policies require schools to be more effective than before. The 21st century's need for variety in skills and abilities necessitates schools not only to be effective but also to keep up with the changes of the modern world. Effective schools can be described as a type of school that creates a difference in students and adds values to them. Effectiveness of the students can be determined by many factors such as the vision of the school leaders, physical conditions of the schools or parents' socio-cultural backgrounds etc. In this study, performance evaluation systems and processes, which directly influence school effectiveness, are discussed in relation to organizational justice. The relationships between performance evaluation systems and organizational justice are examined in the light of the studies in the literature. The previous studies in the literature clearly show that teacher performance plays a critical role in school effectiveness. However, in order for performance evaluation systems to serve school effectiveness, teachers should have a positive perception of organizational justice in their own schools. In the light of previous studies, it is safe to claim that unless certain.


: In this paper we examine the effect of doping phosphate into BaCe 1 − y A y O 3 − y /2 (A = Y, Yb, In). The samples were analysed through a combination of X-ray diffraction, TGA, Raman spectroscopy and conductivity measurements. The results showed that phosphate could be incorporated into this system up to the 10% doping level, although this required an increased Y/Yb/In content, e.g., BaCe 0.6 (Y/In/Yb) 0.3 P 0.1 O 2.9 . The phosphate doping was, however, shown to lead to a decrease in conductivity; although at low phosphate levels high conductivities were still observed, e.g., for BaCe 0.65 Y 0.3 P 0.05 O 2.875 , σ = 4.3 × 10 − 3 S cm − 1 at 600 °C in wet N 2 . In terms of the effect of phosphate incorporation on the CO 2 stability, it was shown to lead to a small improvement for the In containing samples, whereas the yttrium doped compositions showed no change in CO 2 stability.


One of the New Curriculum Criterion characteristics was emphasizing probability and statistics. Probability and statistics was an indefinite mathematics and it was different from definite mathematics, which took a dominant position for a long time in middle mathematics. So students?random mathematics consciousness would be developed from the method of teaching, thinking and studying.


The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1 reverse transcription at the center of HIV-1 linear DNA genomes. These triplex structures can act as a cis-determinant of HIV-1 DNA nuclear import, allowing infection of non-dividing target cells. In one aspect, the presence of the DNA triplex sequence in an HIV vector strongly stimulates gene transfer in hematopoietic stem cells. The invention also provides methods of using these triplex structures for making recombinant cells, as well as methods of using the recombinant cells to express proteins of interest both in vitro and in vivo.


An initial increase (3-12 hr) in the polymorphonuclear leukocytes (PMN) counts after ligation of the rat left main coronary artery was reduced by 49.4% (at 12 hr) by a 5-lipoxygenase inhibitor, AA-861 (80 mg/kg, p.o., 1 hr before ligation). Depletion of the complement components induced by cobra venoma factor (CVF) (i.v.), given one day before, resulted in significant reduction in the PMN accumulation after 12 hr (by 63.6% at 24 hr). The combined treatment (CVF+AA-861) suppressed the PMN accumulation by 69.7% (24 hr). The infarct size at 48 hr was also reduced by approximately 36% by either AA-861, CVF or combined treatments.


A case study of the Defence Research Agency, a public sector scientific organization.

Shows how fundamental business processes were changed to enable the organization to operate in a more effective way.

The organization became more commercial and a customer-oriented culture resulted, in contrast to the previous bureaucracy.

The changes resulted in an overall reduction of staff of 2000 (although the number of scientists employed rose) whilst output has been maintained.

The case study shows how a major and fundamental strategic change can be successfully implemented.


The amount of impervious areas in Malmo continue to increase as the city expands. These urban areas are already difficult for trees, with their heat and drought, and they will be even more difficult with climate change. Therefore, we must use tree species that can cope with these challenges.

To find these, a trip was made to Hilversum in the Netherlands where an inventory of city trees was carried out. A literature study to find more information about the species has also been made.

With the result of the inventory and literature study, we have arrived at five tree species that can cope with the challenges and can be expanded in use in future Malmo.


A channel interleaving method, the channel interleaver and channel encoding means. Channel interleaver comprises a constellation-based permutation module. A plurality of first channel interleaver before receiving the generated forward error correction encoder sets of encoded bits. Encoded bits are distributed up subblocks and each subblock comprises a plurality of adjacent bits. Subblock interleaver interleaves each subblock and outputting a plurality of interleaved bits. Constellation-based permutation module rearranging the interleaved bits and outputting a plurality of rearranged bits. Rearranged bits are supplied to a symbol mapper, encoded bits prior to avoid concentration of a plurality of forward error correction encoder coded bits are mapped in consecutive modulation symbols having the same level of bit reliability. In addition, to avoid the bits are mapped to modulation symbols having the same level of bit reliability to achieve constellation diversity and to improve the decoding performance of each sub-plurality of adjacent blocks.


In the light of frequent jamming at intermediate pressure main stop valve of homemade 300MW turboset,disassembly analysis of the faulty main stop valve was carried out and appropriate modification was made.


Underactuated compliant robotic hands exploit passive mechanics and joint coupling to reduce the number of actuators required to achieve grasp robustness in unstructured environments. Reduced actuation requirements generally serve to decrease design cost and improve grasp planning efficiency, but overzealous simplification of an actuation topology, coupled with insufficient tuning of mechanical compliance and hand kinematics, can adversely affect grasp quality and adaptability. This paper presents a computational framework for reducing the mechanical complexity of robotic hand actuation topologies without significantly decreasing grasp robustness. Open-source grasp planning software and well-established grasp quality metrics are used to simulate a fully-actuated, 24 DOF anthropomorphic robotic hand grasping a set of daily living objects. DOFs are systematically demoted or removed from the hand actuation topology according to their contribution to grasp quality. The resulting actuation topology contained 22% fewer DOFs, 51% less aggregate joint motion, and required 82% less grasp planning time than the fully-actuated design, but decreased average grasp quality by only 11%.


By using joint-teaching and problem-based discussion through the organic integration of the related knowledge of histology,anatomy and physiology of nervous system,we aim to explore the application of joint-teaching model in medical students of the long-term system.The results showed that,compared with the traditional teaching model,joint teaching not only efficiently realized the integration of gross structure,microstructure and function of nervous system,but also has a great advantage to cultivate the comprehensive abilities of students such as active learning and thinking expansion.Therefore,we suggest that medical students of the long-term system may have priority to be carried out joint-teaching model with organ system-based integration teaching method.


My argument in the following will be that experiences tied to video games are potentially generic in the sense of having the potential to be experienced as similar to other experiences. This is partly because human experience is inextricably bound up with typicality and generality, partly because video games themselves are generic products. While games may utilize a very large set of intersubjectively shared generic resources, players are also individuals with individual biographies: This is why game experiences are only potentially generic.


This study investigated the ways in which the technological tool, The Geometer's Sketchpad, mediated the understandings that high school Honors Geometry students developed about geometric transformations by focusing on their uses of technological affordances and the ways in which they interpreted technological results in terms of figure and drawing. The researcher identified different purposes for which students used dragging and different purposes for which students used measures. These purposes appeared to be influenced by students' mathematical understandings that were reflected in how they reasoned about the physical representations, the types of abstractions they made, and the reactive or proactive strategies employed.


Objective: To determine the accuracy, quality and timing of ophthalmic referrals. Design: This was a prospective study. The data was collected using a pro forma. All patients gave voluntary written consent. Setting: The Ophthalmology Division at the University Hospital of the West Indies Participants: All new patients referred to the Ophthalmology Division from August 3, to November 3, 2016. It excluded patients referred for disease screening. Result: There were 207 patients recruited, 114 (55%) males and 93 (45%) females, aged four months – 87 years (Mean age 45.4years, SD 20.8). The majority were from general practitioners (33%), followed by ophthalmologists (28%) and emergency physicians (23%). The most common conditions were glaucoma (12%), cataract (10%) and uveitis (10%). Only 20% of referrals contained all four referral elements history, examination, visual acuity and diagnosis. Ophthalmologist referrals were most accurate (89%), while general practitioners (29%) were least accurate. Mean time from referral to the patient presenting to the eye clinic and being seen was 82 days for routine and 4.2 days for emergent/urgent referrals. There were 41 adverse events (19.8%); delays due to physician factors (inappropriately written referrals, inappropriate medications used or lack of disease screening) or patient factors including prolonged time to presentation. Conclusion: There is a high-rate of poorly written referrals and inaccurate diagnoses. Inadequate communication, poor timing of referrals, inaccurate diagnosis and treatment affect patient outcomes. With standardized referrals, patient morbidity may be reduced.


In order to identify the structure damage location and overcome the disadvantages of BP network,such as being affected greatly by ill samples and having poor antinoise ability,SOFM(Self-Organizing Feature Map)network is adopted to identify the damage location in a truss structure.The identification results show that SOFM network can distinguish similar samples and give intuitionistic judgement of the identification results through the topology map.When the noise is removed,the damage location can be identified correctly.When the noise level is under 30%,all the elements except individual element can be identified correctly in a probability over 95%,which shows that the SOFM network has a powerful antinoise ability.


1. Basic concepts and operations 2. Getting started 3. Development 4. Packaging, testing, and delivery issues 5. Extending and customizing the system 6. Administration 7. Goodies 8. Packaging 9. Troubleshooting.


Although macula densa (MD) cells are chief regulatory cells in the nephron with unique microanatomical features, they have been difficult to study in full detail due to their inaccessibility and limitations in earlier microscopy techniques. The present study used a new mouse model with a comprehensive imaging approach to visualize so far unexplored microanatomical features of MD cells, their regulation and functional relevance. MD-GFP mice with conditional and partial induction of green fluorescent protein (GFP) expression, which specifically and intensely illuminated only single MD cells were used with fluorescence microscopy of fixed tissue and live MD cells in vitro and in vivo with complementary electron microscopy (EM) of rat, rabbit, and human kidney. An elaborate network of major and minor cell processes here named maculapodia were found at the cell base, projecting towards other MD cells and the glomerular vascular pole. The extent of maculapodia showed up-regulation by low dietary salt intake and female gender. Time-lapse imaging of maculapodia revealed highly dynamic features including rapid outgrowth and an extensive vesicular transport system. EM of rat, rabbit, and human kidneys, and three-dimensional (3D) volume reconstruction in optically cleared whole-mount MD-GFP mouse kidneys further confirmed the presence and projections of maculapodia into the extraglomerular mesangium and the afferent and efferent arterioles. The newly identified dynamic and secretory features of MD cells suggest the presence of novel functional and molecular pathways of cell-to-cell communication in the juxtaglomerular apparatus (JGA) between MD cells and between MD and other target cells.


Energy demand is increasing exponentially nowadays, which primarily causes the burning of fossil fuels creating enormous amounts of environmental degradation. To arrest this, the need for clean and green technologies...


In this paper, we construct a class of association schemes by using pairs of subspaces of vector spaces and determine their full automorphism groups.


This paper presents 2.5-6 GHz phased-array transmitter, which can be used to generate 1-kW peak pulsed output. It consists of 16×12 transmit modules and each transmit module with greater than 37.5 dBm of CW output power is attached to rigid tapered slot antenna. In transmit module, integrated multi-function corechip is designed in order to individually control both amplitude and phase of array antennas. Far-field radiation pattern of active phased-array transmitter was obtained using fieldtransformation method after carrying out near-field measurement in anechoic chamber. Electronic beam steering capability of active phase-array transmitter was demonstrated with a scan angle of ±7 o in both azimuth and elevation angle. The overall system size is 620×421×771 mm 3 .


Fast beam-ion losses were studied in DIII-D in the presence of a scaled mock-up of two Test Blanket Modules (TBM) for ITER. A hot spot on the TBM surface was found when neutral beams were injected and the TBM fields were engaged while the fast-ion core confinement was not affected. Different orbit-following codes predict the formation of a hot spot on the TBM surface in good agreement with the experiments. The hot spot is formed by beam-ion losses from the edge of the plasma. The codes agreed amongst each other on the power deposited at the hot spot. The simulated power deposition profiles were used to calculate the measured temperature response of the tile. A good qualitative agreement was found for the time history of the tile temperature but the peak temperatures were not well reproduced. This is probably caused by the beam-ion distribution that was used in the simulations. From these experiments it can be concluded that effective mitigation techniques exist if hot spots from fast-ion losses form due to TBM fields which is good news for ITER.


The effects of supplementation with types of probiotics for beagle puppies that received high and low quality diets on the findings of imaging techniques were evaluaded. Eighteen animals were distributed in three randomized treatments: 1, control (diet), 2, diet with a probiotic (Bifidobacterium), and 3, diet with another probiotic (Lactobacillus). The experiment was divided into two phases each characterized by a change of diet. By ultrasonography, the thickness of the gastrointestinal wall was evaluated as well the presence of gas in the bowel and thickening of the wall by radiography. There was an increase in the thickness of the intestinal wall (P 0.05) were observed among treatments for scores of intestinal gas. The quantitative analysis allowed the determination of a score of intestinal gas, noninvasively, using the software Image J ®. It was concluded that the imaging technique supports the recommendation of this method as an auxiliary tool in nutritional assessment of diets for dogs.


transgenic mouse comprising two human immunoglobulin loci, wherein one human immunoglobulin locus is a human heavy chain locus located on a transchromosome, and the other human immunoglobulin locus is a portion of a transgene human light chain locus integrated stably in the mouse genome and encoding a human light chain.


Rheumatoid arthritis hasahighmorbidity buta lowmortality. Onecause ofdeath inthis disease is compression ofthecervical cordfollowing atlantoaxialsubluxation. Thismakesthefinding of atlanto-axial subluxation of greatimportance, although therelationship ofsmall amounts ofsubluxation tosymptoms andsubsequent progress has notbeenestablished. Similarly, theimportance ofachance finding ofsubluxation isuncertain. Inthis study, theentire rheumatoid population ofahospital clinic hasbeensurveyed bothclinically andradiologically todetermine theincidence of this abnormality.


This application note describes the growth of Bismuth Telluride (Bi 2 Te 3 ) in the Royce Institute thin films deposition facility and presents data demonstrating the material's properties.


Single crystal of M phase Yb:YTaO<inf>4</inf> was grown by the Czochralski method. Large emission cross-section (1.05×10−20cm2), wide FWHM of absorption and emission, and long lifetime (0.74ms), indicate that Yb:YTaO<inf>4</inf> is very promising laser crystal used in all solid state ultra-short laser.


Abstract One of the most versatile types of heat exchangers used is the plate heat exchanger. It has principal advantages over other heat exchangers in that plates can be added and/or removed easily in order to change the area available for heat transfer and therefore its overall performance. The cooling systems of Egypt's second research reactor (ETRR 2) use this type of heat exchanger for cooling purposes in its primary core cooling and pool cooling systems. In addition to the change in the number of heat exchanger cooling channels, the effect of changing the amount of mass flow rate on the heat exchanger performance is an important issues in this study. The inertia flywheel mounted on the primary core cooling system pump with the plate heat exchanger plays an important role in the case of loss of flow transients. The PARET code is used to simulate the effect of loss of flow transients on the reactor core. Hence, the core outlet temperature with the pump-flywheel flow coast down is fed into the plate heat exchanger model developed to estimate the total energy transferred to the cooling tower, the primary side heat exchanger temperature variation, the transmitted heat exchanger power, and the heat exchanger effectiveness. In addition, the pressure drop in both, the primary side and secondary side of the plate heat exchanger is calculated in all simulated transients because their values have limits beyond which the heat exchanger is useless.


The pursuit of ever higher mass-resolving power in Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has driven a demand for higher magnetic field strength and longer time-domain ICR signal lifetime, with proportionate increase in data set size in direct-mode detection. Heterodyne-mode detection thus becomes increasingly important for achieving ultrahigh-mass resolution from a fixed maximum-size data set. Unfortunately, as conventionally performed (i.e., analog single phase), heterodyne detection reduces the S/N ratio by a factor of 21/2 relative to direct-mode detection. Here, we restore the factor of 21/2 by use of quadrature heterodyne detection. In addition, replacement of analog by digital heterodyning eliminates analog circuitry (and its associated noise). Finally, digital filtering of the time-domain discrete ICR signal not only eliminates the need for a bank of analog low-pass filters but also ensures that the Nyquist bandwidth and filter bandwidth are always matched, for opt...


A specific powder specimen stage was designed.Sputtering deposition was used to pre-deposite Cu films and Ti/Cu bilayer on diamond powders surface.Then copper films were thickened to prepare diamond/copper composite powders by electroless copper plating.The results show that,after modified by sputtering deposition,the diamond powders can be used to prepare diamond/copper composite powders by electroless copper plating without activation and sensitization.Therefore the process can avoid introducing Sn,Pd and other impurities.The copper coating is more compact and has a better thermal shock resistance after adding Ti as a buffer layer.


This paper expounds some theoretical issues and policy proposals in connection with the reinforcement of developing eco_industry in the construction of Hainan as an eco_province. Furthermore, the author of the paper opines that the way for developing agriculture, industry and tourism in Hainan lies in the ecological trend and that priority should be given to developing the environment_related industry over other various industrial sectors.


Short-term ageing of bituminous binders is a well-accepted concept that represents ageing of binders during plant mixing, production, transportation and construction. Simulation of this ageing is carried out in controlled laboratory conditions and these aged binders are used to predict binder rutting performance. Similarly, the simulation of long-term ageing of binders accounts to ageing of the binder during service life of the pavements and these binders are used to characterise the binder response to fatigue performance in the SUPERPAVE test protocol. Two well-established laboratory test methods are generally practised for evaluating the short-term ageing of bitumen binders: (i) the thin film oven (TFO) test method where a pan filled with bitumen is placed on a rotating pan on the horizontal plane and (ii) the rolling TFO (RTFO) method that uses cylindrical glass bottles filled with bitumen which are rolled in the vertical plane. In the case of long-term ageing, simulation is performed in a pressurised ageing vessel (PAV) under constant conditioning of pressure and temperature. The RTFO and PAV are the part of the test protocol of SUPERPAVE specifications. These equipments are costly and may not be available to different agencies and thereby it has become difficult to adopt any studies involving short- and long-term ageing of binders. Any alternative procedure developed that provides similar ageing effects comparable to the SUPERPAVE method would help highway agencies to adopt and study the effect of ageing on binders. Keeping this as the main concern, an attempt is made to develop a cheap and generalised method for short-term and long-term ageing effects using a normal laboratory oven. Six binder types consisting of two each from viscosity grades, penetration-grade polymer-modified binders (PMB) and crumb rubber-modified binders, were considered in this study. Binders were aged in RTFO and PAV ageing and tested for rheological properties using the dynamic shear rheometer. Similarly, these binders were also aged in a normal oven kept at a constant temperature for varying periods of ageing. Test results were compared on the basis of rutting and fatigue criteria to arrive at the time of ageing required in a normal oven that would be similar to RTFO and PAV ageing, respectively. The study revealed that it is possible to correlate ageing methods of SUPERPAVE with a normal oven method and arrive at an alternative method of ageing. In order to compare the actual short-term ageing of one of the modified binders, bituminous mixes were collected from the field during mix production, transportation and compaction, and binders from these were extracted. Rheological parameters of the extracted bitumen from field samples collected during different stages of construction, RTFO and normal oven-aged samples were evaluated and compared. It was found that the actual ageing is different from RTFO and a normal oven ageing and thereby there is a need to carryout a detailed study on ageing characteristics of Indian binders.


The present paper calls for a reopening of the foreign language aptitude research.As such,it will first briefly review some of the developmental milestones of foreign language aptitude research in the past several decades,which gives rise to possible lacunas in the field.Then the present paper will elaborate on four recent attempts by aptitude researchers to reconceptualize the foreign language aptitude construct,thus laying the ground for future endeavors to further develop the theory.The paper concludes by outlining some basic principles guiding future research falling into line of inquiry.


Ergon Energy operates over 64,000 kilometres of Single Wire Earth Return (SWER) networks to supply electricity in rural and remote regions of Queensland. Much of the SWER network is approaching designed capacity limits due to unprecedented electrical demand brought by the proliferation of low cost, energy intensive home appliances. The objective of this study is to examine the effect of deploying distributed low voltage switched capacitor banks to provide customer voltage support and release additional network capacity.


The green movement is currently a hot topic within the cosmetics industry. This interest has been created by the announcement of large retailers that they will only sell products manufactured by green companies.


Kalininskaja nuclear power plants (KNPP) is located in Kresttsovskiy-Valdai aulocogene of sublatitudinal extension. The paper presents the GPS observations of modern movements of the earth's crust (MCM) that was carried out in 1996-2002 around KNPP.


The back extraction of UO 2 2+ ,Pu(Ⅳ),Am 3+ and TcO 4 - with 2 hydroxyethyl 1,1 diphosphonic acid (HEDPA) solution from 30 % TRPO(mixed trialkyl phosphine oxide)/ kerosene and 20 %TRPO 20 %TBP(tributyl phosphate)/kerosene systems is studied. Two kinds of HEDPA with different purity are compared. The effects of nitric acid concentration and HEDPA concentration on the back extraction are demonstrated. Based on the experimental results , a TRPO process using HEDPA as the back extractant is proposed.


The review of the modern state and the perspectives of bulk acoustic wave composite resonators is presented. Special attention is paid to the following topics: what composite resonators are, modern composite resonators including multifrequency resonators, the thin-film resonators with and without acoustic isolation from the substrate. A particular review of the microwave bulk acoustic spectroscopy of the materials - the measurements of attenuation and elastic coefficients is presented.


ducting and interpreting tests of what children learn in school. The five myths are indeed myths. Yet her associated argument against the credibility of properly adjusted test scores is logically troubling. Unadjusted test scores, she correctly states, are grossly misleading for comparing the quality of schools because they are affected by many other factors as well. Then she invites a "catch-22" by also stating that statistical adjustment to filter out the influence of such factors "has not worked." Rotberg's alternative is to judge an educational practice "on a careful consideration of the merits." She does not say, however, how merit should be determined. Surely, judgment of merit would require evidence of student learning. Otherwise, we are thrown back on the myriad we-know-a-good-school-whenwe-see-it contradictions of expert opinions and educational philosophies. Evidence for merit in science education at one time was children seated quietly in rows with work sheets; currently, it is noisy children at tables making up their own hands-on investigations; tomorrow, it may be children sitting slack-jawed in front of computer terminals. Education is as much a victim of untested fads as it is of fads in testing. Credible comparisons of test scores do seem possible because Rotberg finds them good enough to prove the impact of other factors: "Research shows, however, that per pupil expenditure, teacher expertise, and class size do make a difference in student achievement." (She also says that tests can be useful to describe national trends.) A useful follow-up Policy Forum would discuss how those differences could have been demonstrated in spite of the alleged impossibility of comparing the achievement of different groups of students through testing. Andrew Ahlgren* University of Minnesota, Minneapolis, MN 55455, USA


An ontology development tool is often the first thing that people get to see when they venture into the Semantic Web field. Ontology editors and visualization tools therefore carry a special responsibility for the success of the Semantic Web community. At the same time, the user communities around such tools serve as melting pots which can be exploited to collect feedback on the overall design of the language and associated systems. Protégé is one of the most used development platforms for ontology-based systems. This paper report on the experiences of using Protégé with OWL. The intention of the Protégé and specially Protégé Plugin is to make Semantic Web technology available to a broad group of developers and users, and to promote best practices and design patterns. In this document we walk through a selection of these issues and suggest directions for future work and standardization efforts.


We discuss the probability that among a number of random discrete values there is a unique maximal value. Some general inequalities are derived. As an application, we study the limit behavior of the probability of uniqueness for a subexponential number of binomially distributed variables.


Objective To observe antitumor activity and inducing apoptosis of low molecular weight polysaccharide isolated from Agaricus blazei Murill (LMPAB) on sarcoma 180 in mice.Methods The BALB/c mice inoculated in armpit with S180 cell suspension were treated by intraperitoneal injection of LMPAB [50 100 and 200 mg/(kg·d)] for 7days,The mice were sacrificed after 24h and tumor tissues were weighed respectively. Tumor cell apoptosis was detected by Annexin-Ⅴ-FITC/PI (Flow cytometry).Results In LMPAB group [200 mg/(kg·d)] (0.695±0.096) and Polyporus polysaccharide group (0.704±0.262) tumor weight reduced compared with the model group(1.038±0.262,P0.01),Inhibitory rate of sarcoma 180 in mice treated with 50,100,200 mg/(kg·d) LMPAB was 9.5%,23% and 32%,respectively. The apoptosis rate of sarcoma 180 cells in mice treated with 50,100,200 mg/(kg·d) LMPAB was (39.21±3.85) %,(32.17±5.10)% and (18.71±2.52)%,respectively,higher than that in the model group mice[(10.98±1.55)%].Conclusion LMPAB significantly inhibited the growth of sarcoma 180 subcutaneously implanted in mice,possibly through inducing apoptosis of tumor cells.


The invention relates to a test method and particularly a test method of materials. A test evaluation method of an LED (light emitting diode) packaging adhesive comprises the following steps of: step S1, dispensing and solidifying adhesive to form an LED packaging adhesive film, and preparing an LED packaging adhesive film to be tested; step S2, carrying out light transmittance performance test and other physical property tests on the LED packaging adhesive film; step S3, irradiating the LED packaging adhesive film through a lighting emitting device for light energy shock; step S4, carrying out light transmittance performance test and other physical property tests on the LED packaging adhesive film which is subjected to the energy shock in the step S3; and step S5, comparing and analyzing the test result obtained by the step S2 and the test result obtained by the step S4. The test method provided by the invention can be used for performance test of the LED packaging adhesive.


Ca2+ is a crucial second messenger in plant cells that plays a vital role in various physiological and biochemical processes, including plant growth and development, photosynthesis, and enzyme regulation. Exogenous calcium concentrations can have different effects on plant growth. The purpose of this study was to determine the appropriate calcium concentration for the growth of four tree seedlings, namely Pinus tabuliformis, Pinus sylvestris var. mongolica, Populus, and Morus alba seedlings, and whether this optimal calcium concentration varies among different tree species. This study utilized five calcium concentration gradients (0, 100, 200, 400, 800 mg·kg−1) for each species with three repeated treatments. To determine each species' calcium concentration needs, several growth indices, photosynthetic metrics, chlorophyll fluorescence parameters, water usage efficiency, and antioxidant enzyme activities were analyzed. The results showed that exogenous calcium significantly affected the growth and development of each seedling. The growth, biomass, photosynthetic parameters, photosynthetic products, photosynthetic pigments, water use efficiency, and antioxidant enzyme activity all increased initially and then decreased with the increasing calcium concentration. The exogenous calcium supply increased the concentration of calcium in the leaves. Thus, there was an optimal calcium concentration for plant growth, and a high or low calcium concentration was not conducive to plant growth. Furthermore, this study found that the optimum calcium concentration of different tree species was different. The optimal calcium concentration for Pinus tabuliformis, Pinus sylvestris var. mongolica, Populus, and Morus alba seedlings was 100, 100, 200, and 400 mg·kg−1, respectively, with broadleaf seedlings requiring higher calcium concentrations than coniferous seedlings.


The invention relates to a method for manufacturing a clinker from a raw constituted by a mixture comprising the compounds CaC03, A1203, and / or Al (OH) 3 CaS04, Si02, Fe203, and / or a product containing silica or silicates such as clay, all of which are present in anhydrous or hydrated form, individually or in combination. The process according to the invention comprises the steps of: - decarbonate and dehydrated, at least partially, the mixture by passing through a kiln (1) comprising a vessel (2) substantially vertical within which the mixture is heated; - extracting the mixture dehydrated and decarbonated of the kiln (1) and bringing it into a heating furnace (4) having a home and means of transport of the mixture through the hearth, - heating the mixture from the oven right (1) by passing through the focal point (5), through the transport means, so as to obtain a sintering of the mixture.


Supporting preservice teachers in their development of positive mathematical identities is important because of their future responsibility as teachers to develop their own students' mathematical agency. In this self-study, we investigated a mathematics teacher educator's facilitation practices during discussions to understand whether and to what extent the preservice teachers' mathematical identities were productively impacted. We analysed over 35 hours of video recordings of a mathematics content course for future elementary teachers and identified four key mathematics teacher educator facilitation practices that appeared to productively impact preservice teachers' identity: emphasizing reasoning, promoting broader engagement, shifting responsibility for learning, and developing a supportive classroom community. We also analysed survey data on preservice teachers' perceptions of their mathematical agency and authority. Implications for mathematics teacher educators are discussed.


Morphological changes are described in Japanese flounder Paralichthys olivaceus larvae and juveniles with emphasis on growth during the period of metamorphosis. Ontogenetic changes in condition factor and lipid, glycogen and protein levels were also analysed to determine the utilization of stored energy. Fish grew from 6.6 to 20.3 mm L T (1.15 to 84.4mg in mass, M) during the period from 11 to 40 days after hatching (DAH) at 19.3°C. Per cent specific growth rate per day (% G day -1 ) for wet mass was lowest during the metamorphic phase (21-30 DAH) compared to pre- (11 -20 DAH) and post-metamorphic (31 40 DAH) phases. When L T and M were expressed as M = a L b T , the b value was highest during the pre-metamorphic phase and lowest during the metamorphic phase. These findings indicate that the developmental changes that occur during metamorphosis of Japanese flounder are closely related to the growth pattern. Moisture, lipid and glycogen contents were also at the lowest level during metamorphosis compared to pre- and post-metamorphosis, which suggest that Japanese flounder use their energy reserves to accomplish metamorphosis due to an apparent decline in feeding during this period.


The use of a white-rot fungus, (Pers. Ex Fr.) Pouzar, as a biocontrol agent against sprouting has been studied with good results. The aim of the study was to investigate the efficacy of two pre-commercial thinning machines, Tehojätkä and Mense, to spread an inoculum of as a biocontrol agent on freshly cut birch ( Roth and Ehrh.), European aspen ( L.), rowan ( L.), and goat willow ( L.) stumps (the fungal treatment) and compare that to the control (cutting only, done by Tehojätkä). Efficacy was investigated in terms of stump mortality and the number of sprouts per stump. This study was conducted in one stand and sprouting was investigated for three years after treatment. The fungal treatment resulted in higher mortality of stumps (34.0% for Tehojätkä and 41.5% for Mense after three years), compared to the control (13.4%). However, the fungal treatment did not decrease the number of sprouts per stump compared to the control. The low occurrence of basidiomata indicates that the accuracy of the spreading mechanism was not satisfactory, causing low mortality figures for the fungal treatment compared to previous studies. In the future, this mechanized method may provide a promising alternative in sprout control if the spreading mechanisms, the accuracy of the treatment, and consequently the efficacy could be improved.Chondrostereum purpureumC. purpureumBetula pendulaB. pubescensPopulus tremulaSorbus aucupariaSalix caprea


In spite of the preliminary output of the PIRSIQ project suggesting we do not know or we have very different opinions about what models are, we can still find it profitable to discuss a few principles and rules of model validation. This is interesting because it can lead to an increase in the quality of our models while avoiding the pitfalls of a philosophical debate. In other words, we are taking an operational approach.


Objectives: To assess the payment of pricing factors necessary for achieving optimal community-based distribution of insecticide nets (ITNs) re-treatment services.
Methods: Questionnaire interviews were conducted with randomly selected household heads or their representatives in five malaria holo-endemic communities of Southeast Nigeria. Interviews were also held with community leaders before and after ITNs sales. The sale of ITNs was based on the communities' distribution and payment preferences.
Findings: While payment by installment was preferred for ITNs, it was one-off mechanism for net re-treatment. Most of the respondents that bought the nets paid by a maximum of two fourth-nightly installments, and some of them determined the mark-up price of ITNs over that for untreated nets before buying. The major problems encountered were cases of non-adherence to the payment modality and return of after use. A community-based system was able to sell the nets.
Conclusion: The payment preference of communities should be incorporated in
implementing community-based ITNs sales. Appropriate pricing should involve ITNs programme managers being aware of the price movements in local markets for untreated nets, as a basis for dynamic reasonable price setting for ITNs
Key words: Demand responsive, malaria, insecticide-treated nets, financing, community-based.
[Jnl College of Medicine Vol.8(2) 2003: 36-39]


Oxygen dissolved in the aqueous phase (O/sub 2/)/sub aq/ is an important oxidant in many industrial processes, ranging from pressure leaching and heap leaching of metals from minerals to the bleaching of wood fibers in the pulp and paper industry. Frequently, (O/sub 2/)/sub aq/ is a prime agent promoting corrosion of metals in aqueous systems. This study presents a general solubility model for estimating oxygen solubility in aqueous inorganic solutions over a wide range of conditions. These include changes in oxygen partial pressure P(O/sub 2/) (atm), variations in the process temperature T (K), and changing concentrations C/sub t/ of dissociated inorganic solute I. The model is based on a thermodynamic analysis showing that the concentration c/sub aq/ of (O/sub 2/)/sub aq/ in pure water is dependent upon P(O/sub 2/) and T via an equation of the form c/sub aq/=P(O/sub 2/)f(T), where f(T) is a T-dependent function related to the chemical potential, entropy, and partial molar heat capacity of the gaseous oxygen (O/sub 2/)/sub g/ and dissolved (O/sub 2/)/sub aq/ species. In the presence of a single I, this equation is modified by a /spl phi/-factor such that the new oxygen solubility, (c/sub aq/)/sub I/, becomes (c/sub aq/)/sub I/=/spl phi/c/sub aq/=/spl phi/P(O/sub 2/)f(T), where /spl phi/ is an I-dependent function of C/sub I/. Inorganic solutes of similar stoichiometry, composed of a common anion and having cations from the same group in the Periodic Table, tend to exhibit a similar /spl phi/-factor and (c/sub aq/)/sub I/ value, provided all concentrations, c/sub aq/, (c/sub aq/)/sub I/, and C/sub I/, are reported in molal (m) units (mol/kg H/sub 2/O). Methods for incorporating the effect of multiple I on /spl phi/ are presented and discussed.


The present invention discloses a GLP-1 analog, specifically relating to a GLP-1 remodeling polypeptide which can promote insulin secretion and lower blood sugar so as to treat type II diabetes. The present invention provides a group of GLP-1 analog polypeptide sequence which has a general formula: HX1EGTFTSDX2SSYLEGQAAKX3FIX4WLVKGR (formula I), wherein X1 is Ala, Gly or Val; X2 is Val, Leu or Ala; X3 is Leu or Ser; X4 is Glu or Asn. The internal experiment proves that the polypeptide provided by the present invention has the advantages of longer half-life period, promoting insulin secretion, lowering blood sugar, and is superior to the effect of natural GLP-1.


Recent advances in deep learning, natural language processing, and information retrieval show great potential for enhancing the knowledge and processes in the fields of pharmacogenetics, pharmacogenomics, and pharmacoepidemiology. These techniques allow for the unprecedented analysis of large unstructured datasets that would otherwise be intractable, such as finding relevant patterns and clusters in the data being analyzed (e.g. free-text notes in Electronic Health Records, or Pubmed articles or abstracts). From predicting patient outcomes and guiding drug choices that prevent adverse reactions to drug discovery and repurposing, artificial intelligence holds great promise when it comes to the development of support systems to aid clinical decision making in the coming years. In this Frontiers Research Topic, we invited potential contributors to submit their work and latest advances in deep and machine learning applied to pharmacogenetics, pharmacogenomics, and pharmacoepidemiology. One of the potential applications of ML in pharmacogenomics is to improve dose prediction accuracy, improving outcomes and reducing adverse drug events (ADEs). In this context, Steiner et al. employ regression to predict stable warfarin dosages in a diverse cohort that includes US Latinos and Latin Americans, concluding that the inclusion of ethnicity and warfarin indication, in addition to the International Warfarin Pharmacogenetics Consortium's recommended set of variables can result in a small but significant improvement in correct dose prediction. Also in the field of ADE avoidance, Kang et al. aim to predict the risk of fetal teratogenicity caused by prescribed antiseizure medications (ASMs), which is especially relevant in novel ASMs where prior evidence is limited. To this end, they employ a Support Vector Machine on a series of curated FDA-approved ASMs with risk for teratogenicity, using data from the FDA Spontaneous Adverse Events Reporting System (FAERS) as ground truth and outperforming state-of-the-art approaches. Pandi et al. propose text-mining to automatically compute potential pharmacogenomic associations. To achieve this, PubMed abstracts and articles are selected, PubTator Central annotations are used for entity recognition. Extracted sentences are then used to extract genome-chemical pairs using different classifiers. Finally, Fusaroli et al. propose Adversome, a new approach to detect ADEs and other diseaseand comorbidity-related syndromes in rapidly changing and low-resource environments such as the Edited and reviewed by: Volker Martin Lauschke, Karolinska Institutet (KI), Sweden


1. Name of product design: the combination of car lights. 2. Use of product design: This product is installed in the car trunk panel, including the taillights and reversing light. 3. Design: the design features of this design is that the product shapes and patterns. 4. Specify the image: a perspective view in FIG.


This paper presents the design of a wavelet-like filter bank satisfying approximately a number of desired system properties for restoration of multi-level digital signals embedded in the additive white Gaussian noise. Compared with the traditional wavelet filter banks, the proposed wavelet-like filter bank is shown to provide better performance in terms of signal-to-noise ratio and visual quality. (6 pages)


GEOFFREY SAMUELS, INSEAD The Middle East has begun to embrace the Internet. During the past six years, the region recorded the largest growth in Internet users among the major world areas as the number of Middle Eastern citizens accessing the Web soared by more than 600 percent, three times the world's average increase.The mobile telephone market has become a prodigy market, as liberalization across the region has led multiple vendors competing to lower costs and improve performance to attract record numbers of new customers. However, more important than rising Internet access or ringing mobile telephones is official awareness at the highest levels of Middle Eastern governments that it is no longer possible to relegate information and communication technology (ICT) policies to an administrative sideshow.A country's ICT capabilities can profoundly affect its capacity to innovate and its global competitiveness, as well as improve the socioeconomic prospects of its less-advantaged citizens. Senior-level attention to ICT as a key enabler of innovation has been expressed in different ways in different countries, but a fundamental and salutary change is that these issues now rank as top agenda items.Whether this attention will usher in effective policies, however, remains a debatable issue.


The trilogy, Inferno, Purgatorio, and Paradiso, directed by Romeo Castellucci of Societas Raffaello Sanzio, opened at the Avignon Festival in July 2008. While other theatre works inspired by Dante Alighieri's Divina Commedia (1304-21) have taken the work quite literally, in Castellucci's production one does not find Beatrice, Vergil, devils, or sinners. The trilogy's reference to Dante is not textual but pre-textual, as the company's response to the poem is a production which asks the same questions raised by Dante more than seven centuries ago. What are Hell, Purgatory, and Heaven in the third millennium? How can one represent them? How can one communicate them to a contemporary authence? With three extremely different shows, the Italian theatre company continues their exploration into the notion of the tragic, questioning the role of the artist, the power and limits of representation, and the notion of spectatorship. During the course of an hour-long Skype interview on 15 July 2009, Castellucci and I talked about his Divina Commedia. I began by asking him how he started working on the project. "I started from the title," he replied. Everyone knows what Inferno means, even those who have not read Dante. Everyone of us, in the course of everyday life, has experienced a moment of Hell, and the same thing can be said of Purgatory and Paradise. I am referring to intimate spaces and mental states, not physical places. With its 15,000 verses, Dante's Commedia is one of the most profound, imaginative, and celebrated works of European literature. Why did Castellucci decide to undertake such an arduous challenge? It is a bad idea to tackle the Divina Commedia because it does not lend itself to any kind of representation. It is one of the greatest works of art, because it really is a work of the imagination, not only of the author, but also of the reader. A flowing river of sounds, images, and feelings take place in the Beyond. It is a place that doesn't exist, and where anything can happen. The Artist thus takes on this unprecedented responsibility of creating new worlds that don't actually exist. To answer your question, why did I want to stage the Divina Commedia? I must confess, I don't really know. I can tell you that the title of a show for me is a "door" that leads into it, it is a promise, a promise that something will happen. I didn't want to make an erudite work, but I knew this was a very dangerous undertaking, and this danger inspired me. For Italians, Dante is the father of the mother tongue. The Divina Commedia marks the birth of the Italian language. The holy dimension of this work, which makes it so dangerous, also interested me very much. It was not so much a question of representing Dante, but of being Dante today. As Nicholas Ridout has suggested Creating Worlds 9-12), the idea of "creating worlds" is one that defines Societas Raffaello Sanzio's artistic project, in so far as their theatre does not aim at representing the world, but at creating an alternative reality which obeys its own laws and in which time flows at a different pace. So how did Castellucci imagine Hell? From the very beginning, I thought Inferno would represent the idea of the masses, the people, movements, waves, both in a choreographic sense and in an emotional one. Inferno does not have a clear-cut chronological development, so much so that in every city we go to we change the sequence of actions that take place onstage. It is a show that opens itself up to the city, since it also features a cast of seventy to eighty extras among the inhabitants of the host city. The extras are not just decorative, they become part of the writing of the show. In what follows, I try to recall the memories of the three productions, which I saw in London in April 2009. As the lights go down in the Barbican Theatre for the performance of Inferno, the Artist-Castellucci himself-comes onstage. "My name is Romeo Castellucci," he declares. …


Population planning is inevitable for a sustainable and secure future of a lower middle-income economy, like, Pakistan which stands fifth populous economy across the globe and has high population growth rate. Based on Pakistan Demographic and Health Survey 2017-18 data and by covering a sample of 12339 ever-married females, the study intends to investigate the correlates of family planning services use in Pakistan as well as the use of contraceptives across the regions and districts of Pakistan. An exploration of 34 studies (spanning over a time from 1989 to 2021), specifically on Pakistan, with respect to family planning services utilization, have found that the use of family planning services was an outcome of a woman's education, awareness status, wealth or economic status, religion, husband's approval, area of residence, number of living children, prevalence of the desired family planning method, desire for more children, subsidized healthcare services and other social or individual factors. In Pakistan, the average contraceptive use rate was recorded as between 19-49 percent across the regions and between 0-71 percent across the districts. The region Islamabad Capital Territory (ICT) had the highest contraceptive usage rate, i.e., 49%, followed by: Punjab (42%), Khyber Pakhtunkhwa (KPK) and Gilgit Baltistan (39% each), Sindh and Azad Jammu and Kashmir (AJK) (34% each), Federally Administered Tribal Areas (FATA) (24%), and Balochistan (19%). Amongst the districts, top three districts with highest contraceptive usage were Jafarabad, Sheikhupura and Jhang whereas the districts of Rajanpur, Tor Ghar and Kohlu were lying at the bottom. Region-wise disaggregation found that in the province of Punjab and Sindh, the range of contraceptive use across the districts was respectively ranged between 0-70 percent and 8-60 percent. Likewise, in KPK and Balochistan provinces, the range of contraceptive use had been recorded between 0-59 percent and between 2-71 percent. While the range of contraceptive use in Gilgit-Baltistan, FATA region, and in AJK had been respectively recorded between 9-48 percent, 11-39 percent, and 17-47 percent.


The insulin‐like growth factor I (IGF‐I) signaling pathway has been shown to play an important role in several aspects of cancer biology, including metastasis. The aim of this study was to define the contribution of serum (endocrine) and local (tumour microenvironment) IGF‐I on osteosarcoma tumour growth and metastasis, a cancer that is known to be dependent on the IGF‐I axis. To test this hypothesis, we evaluated the primary tumour growth and metastatic progression of K7M2 murine osteosarcoma cells injected to a genetically engineered mouse [liver‐specific IGF‐I deficient (LID)] in which serum IGF‐I levels are reduced by 75%, while maintaining expression of IGF‐I in normal tissues. We first demonstrated that IGF‐I in the tumour and the tumour‐microenvironment were maintained in the LID mice. Within this designed model, there was no difference in primary tumour growth or in pulmonary metastasis in LID mice compared to control mice. Furthermore, there was no difference in the number or localization of single metastatic cells immediately after their arrival in the lungs of LID mice and control mice, as analysed by single cell video microscopy. Collectively, these data suggest that marked reduction in serum IGF‐I is not sufficient to slow the progression of either primary or metastatic models of osteosarcoma. © 2008 Wiley‐Liss, Inc.


The key whether mathematics teaching in middle school can effectively manifest the cultural value is decided by a teacher's mathematics view and teaching view.The essential way is instantaneously to abstract,summarize and deepen mathematics knowledge in the teaching process.At the same time it is important to let students understand mathematics culture by diverse activities,of course,it is indispensable to diligently construct mathematics classroom culture which can manifest teacher's individual characteristic and mathematics culture characteristic.


The present application relates to an echogenic indwelling catheter, an assembly and a method for medicating a patient with medication such as anaesthetics or other suitable drugs. In one embodiment, the echogenic indwelling catheter comprises a catheter shaft (1) comprising a bore (2), a plurality of radial holes (3) distributed along at least a part of said catheter shaft and configured for delivery of medication, a guidewire (5b) attached to and/or within the bore of the catheter and extending beyond a distal end of the catheter shaft.


The urbanization effect on climate warming over the recent three decades (1978~2007) in Guangzhou, south China, where has experienced rapid urbanization process since China's reform and opening-up initiated in the late 1978, was estimated by comparing surface air temperature (SAT) observations in the urban meteorological station with those in its two surrounding rural stations. The climatic warming trend in Guangzhou city is 0.44°C/decade for the urban station and an average of 0.32°C/decade for the rural stations, resulting in an urban warming rate of 0.12°C/decade and a 27.3% contribution proportion to the climatic trend. In addition, there are obvious seasonal changes in the urban heat island intensity and its contribution to urban warming in the climatic change. The largest seasonal urban warming rate due to UHI is in summer and spring with 0.14°C/decade, the second in autumn with 0.11°C/decade, and the smallest in winter being 0.09°C/decade. The largest contribution of urban warming to SAT trend in season is in summer (51.9%), the second in autumn (27.5%), the third in spring (25.9%), and the least in winter (16.4%). Results indicate that urbanization effect could produce different seasonal pattern in UHI intensity variation, enhance the climatic warming rate, and result in overestimating the climatic warming trend to some considerable extent at the local scale. This study can help further improve the understanding of urban climatic change and global warming.


A traditional heterodyne detector, as a phase-insensitive device, suffers the well-known 3 dB noise penalty caused by image sideband vacuum. In contrast, a heterodyne detector with a bichromatic local oscillator, as a phase-sensitive device, should be exempted from the 3 dB noise penalty, in spite of the existence of the image sideband vacuum. Assuming coherent light at the input, we develop in this work a theory to describe the quantum nature of the phase-sensitive heterodyne detector, in a good agreement with experiment. The absence of the quantum noise of the image vacuum modes in the heterodyne detector may be explained by that the studied detector senses only a single field of light, i.e., the signal field, according to the theory developed.


Communication device capability information and / or methods that utilize and / or devices are described. Device capability information may be broadcast by the device using a first protocol. Protocol may be a beacon-based protocol. Using the device information, device configuration used to communicate the second protocol and / or user data is selected. In some embodiments, the first protocol 300 is a low bit rate protocol that supports less bits / sec, in some embodiments, the second protocol, the data rate in the range of kilobits / sec or further supports significantly higher data rates, a high rate protocol. Typically, the second protocol utilizes a signal phase to communicate information, first protocol, in many embodiments (but not necessarily all embodiments), it does not use the signal phase.


Acute Lymphocytic Leukemia (ALL) is a type of cancer caused by immature lymphocytes inthe bone marrow. Acute Leukemia is common in both children and adults. It can also cause death if leftuntreated. Hematologists diagnose ALL by examining the blood and bone marrow. This method used isslow and takes more time. In this study, the diagnosis and classification of the disease was carried out usingperipheral smear images with the proposed method. In the proposed method, 99.80% accuracy was obtainedby using the DarkNet19 pre-trained model. Then, 1000 features were obtained from Darknet19. 521 of theobtained features were selected with Mrmr feature selection algorithm. The selected features are classifiedwith support vector machines. An accuracy of 99.94% was achieved with the proposed method. The resultsshow that the proposed method can be used as a tool that will certainly assist pathologists in diagnosingALL and its subtypes.


Scientific workflows are a parallel computing technique used to orchestrate large, complex, multi-stage computations for data analysis and simulation in many academic domains. Resource management is a key problem in the execution of workflows because they often involve large computations and data that must be distributed across many resources in order to complete in a reasonable time. Traditionally, resources in distributed computing systems such as clusters and grids were allocated to workflow tasks through the process of batch scheduling. The tasks were submitted to a batch queue and matched to available resources just prior to execution. Recently, due to performance and quality of service considerations on the grid, and the development of cloud computing, it has become advantageous and, in the case of cloud computing, necessary for workflow applications to explicitly provision resources ahead of execution. This trend toward resource provisioning has created many new problems and opportunities in the management of scientific workflows. This thesis explores several of these resource management issues and describes some potential solutions.
This thesis makes the following contributions: 1. It describes several problems associated with resource provisioning in cluster and grid environments, and presents a new provisioning approach based on pilot jobs that has many benefits for both resource owners and application users in terms of performance, quality of service, and efficiency. It also describes the design and implementation of a system based on pilot jobs that enables applications to bypass restrictive grid scheduling policies and is shown to reduce the makespan of several workflow applications by 32%-48% on average. 2. It describes the challenges of provisioning resources for workflows and other distributed applications in Infrastructure as a Service (IaaS) clouds and presents a new technique for modeling complex, distributed applications that is based on directed acyclic graphs. This model is used to develop a system for automatically deploying and managing distributed applications in infrastructure clouds. The system has been used to provision hundreds of virtual clusters for executing scientific workflows in the cloud. 3. It describes the challenges and benefits of running workflow applications in infrastructure clouds and presents the results of several studies investigating the cost and performance of running workflow applications on Amazon EC2 using a variety of different resource types and storage systems. These studies compared the performance of workflows in grids and clouds, characterized the virtualization overhead of workflow applications in the cloud, compared the cost and performance of using different storage systems with workflows in the cloud, and evaluated the long-term costs of hosting workflow applications in the cloud. 4. It investigates the issue of predicting the resource needs of workflow applications using historical data, and describes a technique for collecting detailed resource usage records for workflow applications that is applied to several real applications. In addition to estimating resource requirements, this data can also be used as inputs for simulations of scheduling algorithms and workflow management systems, and for identifying problems and optimization opportunities in workflows. This technique is used to collect and analyze the resource usage of six different workflow applications, which is analyzed to identify potential bugs and opportunities for optimizing the workflows. 5. It investigates issues related to dynamic provisioning of resources for workflow ensembles and describes three different algorithms (1 offline and 2 online) that were developed for provisioning and scheduling workflow ensembles under deadline and budget constraints. The relative performance of these algorithms is evaluated using several different applicationsunder a variety of realistic conditions including resource provisioning delays and task estimation errors. It shows that the offline algorithm is able to achieve higher performance given perfect conditions, but the online algorithms are better able to adapt to errors and delays without exceeding the constraints.


OBJECTIVE: To critically review available data on the effective lower end of the phenytoin therapeutic range for the treatment of seizure disorders. DATA SOURCES: Relevant articles were identified from an English-language search of MEDLINE 1982-1992. Additional references were found in bibliographies of these articles. STUDY SELECTION/DATA EXTRACTION: We reviewed articles that included data on serum phenytoin concentrations (SPCs) and seizure control. Data on concurrent anticonvulsants, seizure diagnosis, and seizure severity were extracted when available. DATA SYNTHESIS: The original study defining the phenytoin therapeutic range as 10–20 mg/L is analyzed; it was based on a small, homogeneous sample that cannot be generalized to a more diverse epileptic population. Many studies report patients obtaining seizure control with SPCs below 10 mg/L. Studies including a range of seizure diagnoses and severity have a larger variability in effective SPCs; however, effective SPCs are reproducible. CONCLUSIONS: The therapeutic range of phenytoin is defined on an individual basis. Some patients, especially those with infrequent, primary tonic-clonic seizures, may be controlled with phenytoin concentrations below the recognized reference range of 10–20 mg/L.


Direct‐to‐Earth transmissions with optical on/off‐keying are becoming the method of choice to realize telemetry downlinks from low Earth orbit satellites at highest data‐rates. Here, we review the calculation procedure for a practical assessment of the mean link budget in this space‐ground data communication technology. We present a comprehensive survey of the dynamic orbital and beam‐pointing effects as well as the impacts from atmospheric attenuation on the link performance. The paper provides an exhaustive review of the formulas commonly used and propounds a recipe to reliably estimate the received power on ground. An overview of typical data transmitter terminals, transmission channel parameters, and the according optical ground stations is provided. Comparison with measured received powers over transmitter elevation angle and the respective design estimates serves for verification.


Disposable syringe ligation of the present invention, comprising a gun body, a suction cup, suction duct, slid, the push tube, the trigger and apron, wherein: the negative pressure is provided with a detachable suction means on the gun body, is provided inside the negative pressure pump is fixed on the gun body between the seat and the traction slid guide plate, the guide plate is provided on both sides of a rotation shaft, left and right traction rope traction rope end are fixed to both sides of the fifth wheel, and the other end after two bypass shaft guide plate forming a main traction rope, traction rope wound around the main rotational shaft; during the rotation of the trigger, you can drive the push tube Release apron. Injection ligation of the present invention, when the trigger is rotated, the outer surface of the suction cup gasket can be launched at realizing hemorrhoids ligation pairs. By vacuum suction means, to achieve the adsorption of lesions in patients before ligation operations, drug treatment and facilitate ligation operation, and the negative pressure suction apparatus can be recycled and reduce costs.


Issue related to control-loop interaction in a multi-output dc-dc converter with magamp post-regulators was discussed in this paper. The interaction occurs with peak current mode control using primary current sensed. Due to irregular pulse current from magmap circuitry,main loop and magamp control-loops are coupling,which even makes main and auxiliary outputs oscillate. Small signal models of magmap loop and whole system were derived,interaction mechanism was analyzed and it was revealed that control-loop interaction is another expression of worse cross regulation. Corresponding solutions were presented with cross output impedance analysis. And control-loop interaction could be settled with higher outer-loop gain of main circuit or slope compensation.


India's largest size 3.6 meter Devashal optical telescope (DOT) was commissioned in the year 2016, though the idea of building it germinated way back in the year 1976. This article provides research accounts as well as glimpses of its nearly four decades of journey. After a decade of site surveys, location of Devasthal in central Himalyan region of Kumaon was identified. Thereafter, a detailed site characterization was conducted and project approvals were obtained. The telescope is designed to be a technologically advanced optical astronomy instrument. It has been demonstrated to resolve a binary star having angular separation of 0.4 arc-sec. After the technical activation of the telescope on March 30, 2016, it has been in regular use for testing various back-end instruments as well as for optical and near-infrared observations of celestial objects. Back-end instruments used for these observations are 4KX4K CCD imager, Faint object imager cum spectrograph and TIFR near-infrared camera-II. A few published science results based on the observations taken with the telescope are also presented. Furthermore, the routine observations find that for a good fraction of observing time the telescope provides sky images of sub-arc-second resolution at optical and near-infrared wavelengths. This indicates that the extreme care taken in the design and construction of the telescope dome building has been rewarding since the as-built thermal mass contributes minimally so as not to degrade the natural atmospheric seeing measured at Devasthal about two decades ago during 1997-1999 using differential image motion monitor. The overall on-site performance of the telescope is found to be excellent and at par with the performance of other similar telescopes located over the globe.


The field of disability studies (DS) has grown rapidly in North America and around the world over the past 20 years.1–3 Canada has seven designated DS programmes across the country and DS courses in other areas of concentration in a variety of disciplines, such as the humanities.4 DS is now also being taught in non-DS health professional academic programmes—including physical and occupational therapy and rehabilitation courses in the United States.5 Consistent with these initiatives, Judith Heussman's keynote address at the 2007 World Congress of Physical Therapy6 emphasized the importance of physical therapists working with the community with disabilities. These developments guide the perspectives described in this editorial. In Canada, DS has not secured a substantial foothold, in general, in the allied health professional programmes—physical therapy (PT), occupational therapy, speech language pathology, and social work. However, in the Department of Physical Therapy at the University of Toronto, we have been developing content for, and teaching, critical disability studies (CDS) since the 1990s—more than 25 years. We began teaching DS at a time when no other PT programme in Canada offered this content and critical perspective to their students.


Plasmablastic lymphoma (PBL) is classified under the category of 'Mature B-cell neoplasms'. Plasmablastic lymphomas are the most common and account for 30% of all the cases type. PBL is an uncommon B-cell tumor which is limited to the jaw and oral cavity at presentation but can spread to distant sites at later stages type. Here we case report a 35 year old male presented to OPD as hard palate mass which turns to plasmablastic lymphoma after investigation.

Keywords: Plasmablastic Lymphoma (PBL), Triglycerides (TG), Low density lipoproteins (LDL).


This research aimed to calculate time allocation of family labor on cattle farming based on gender, and to analyze some factors influencing the time allocation for beef cattle farming. The research was conducted in Jepara, Indonesia. The research respondents were 71 beef cattle farmers selected by purposive sampling. Data were analyzed descriptively and multiple linear regression analysis. The contribution of women to the allocation of work time was 25.11% and 74.89% for men.The ratio of the time allocation of the female family workforce to that of male family workforce on beef farming was influenced by all independent variables simultaneously with R2 of 0.407. Partially independent variables having positive effect significantly on the dependent variable were the proportion of women productive age and the proportion of men who work outside farming (P≤0.01). The independent variables having negative effect significantly on the dependent variable were the proportion of education for women who have completed 12-year basic education; the proportion of women who work outside farming (P≤0.01), and the number of children under five years old (P≤0.10). It can be concluded that the small-scale beef cattle farming in the rural, the male family workforce was more dominant than the female family workforce.


The analysis of five spectra of the Bp He-weak Si star HD 28843 recorded by the SWP camera on board the International Ultraviolet Explorer reveals variations of the far-ultraviolet spectral energy distribution over a time interval of 4 yr and eight months. Variations are present shortwards of 1700 Å which can be partly attributed to variations of lines and continuum of Si ii. Other lines due to C ii and Si iii also contribute to the opacity in this range too. The variations suggest that silicon is not distributed in a uniform manner over the surface and that the horizontal gradients of the silicon abundance are probably quite large.


It is difficult to demand employee productivity, especially when Covid-19 limits social interaction. Continuous extra attention needed so that employee performance gets optimal evidence. By focusing on leadership styles, organizational commitment, and job satisfaction, this study attempts to select how these three factors transmit the performance of 'Resort X' employees in the Anambas (Province of Riau Islands, Indonesia). The sample involves the entire population to be asked for information related to relevant questions about these variables through census techniques. After the questionnaires distributed and collected, data validation applied using multiple linear regression methods and IBM SPSS. Effects simultaneously and partially describe that leadership style, organizational commitment, and job satisfaction play a significant role in employee performance. Despite the disruption caused by the global pandemic, it did not change the productivity of employees in promoting and attracting tourist visits. Tourist destinations need to adapt and strive for recovery through optimal resources.


A numerical investigation of powered resonance tube is carried out to study the effect of geometry on the unsteady flow characteristics and mass flow variations. Computational results for pressure fluctuations and sound pressure level (SPL) spectra are presented for different tube configurations. The results demonstrate that both amplitude and frequency for pressure oscillations in the gap are strongly dependent on tube length and separation distance.Copyright © 2003 by ASME


Beowulf cluster has created a lot of impact by delivering an excellent prize/performance and scalable computing systems to high performance computing community. Nevertheless, the widespread use of beowulf clusters has not happened as fast as it should be. One of the major problem is that the software tools on beowulf system is still in a very primitive state. Therefore, it is difficult for a small research group consisting mainly of non-computer scientists to build and maintain the cluster for their use. In this paper, many factors that contribute to the problem has been identified especially the unnescessary complexity that were built into the software. Some of the solutions to this problem have been proposed.


A technique that approximates the output of the soft morphological operators is described. The soft operators can be viewed as a voting process across neighborhoods defined by the structuring element. Instead of processing all votes across a neighborhood, this approximation technique randomly samples elements in the neighborhood and uses these values as inputs to a two-state finite state machine, where the state of the machine corresponds to the output at a given pixel. When properly designed, the machines sample a small fraction of the neighborhood, obtain output that is 91 to 100% accurate at each pixel, and is one to two orders of magnitude faster than conventional algorithms. Experiments on binary textures and digits confirm the theoretical results.


As contemporary controversies swamped the beleaguered Agency, the former president mused upon his time in the Oval Office and – looking to implicitly deflect any personal culpability for current crises – suggested, 'I think it has become necessary to take another look at the purpose and operations of our Central Intelligence Agency.' Having 'diverted from its original assignment', the work and activities of the CIA 'has led to trouble [for the US government] and may have compounded our difficulties in several explosive areas.' The sentiment could have applied to any American president since World War II. The ascent of the United States to global superpower was not without transgressions. Every administration would witness a political storm related to foreign affairs that, more often than not, involved the CIA. As it turned out, it was the man that signed the legislation creating the Agency who issued the lament, Harry Truman. The notion that the CIA has, over time, undermined US foreign policy objectives has proved a powerful construct in political, congressional, journalistic, academic, civilian, and fictional discourse. From botched covert operations in Eastern Europe during the 1940s to recent revelations about 'extraordinary rendition' and secret prisons, as well as intelligence 'failures' from the 1949 Soviet atomic bomb testing to the case for the 2003 Iraq invasion, responsibility for crises in American national security have frequently fallen at the feet of the CIA. In part, Truman and his staff had intended it to be this way. It is nonetheless remarkable that a fundamental


The present invention discloses a method for detecting the phase variation of one two o'clock remote sensing images. The present invention is two o'clock remote sensing image change detection method, the classification process with Gaussian Markov Random Field model combination, enhance the effective use of the spatial image information, improve the detection accuracy changes.


In this issue of the Mayo Clinic Proceedings (pages 28 to 32), Malek and coworkers discuss their experience with visual laser ablation of the prostate (VLAP) in 47 patients with benign prostatic hyperplasia (BPH). Symptoms from BPH are reported in almost half of all men by the age of 75 years. I Although patients may describe identical symptoms, the degree to which these symptoms affect the quality of a person's life often differs substantially. Frequently, the deci sion to treat is based on subjective criteria, and simply mak ing the decision to treat BPH has resulted in decreased symptoms.' The patient and the physician should collabo ratively decide when and how to treat BPH. Malek and associates, my colleagues and I,3 and other investigators'> have found that VLAP is a safe and effective treatment. Therapeutic Options for BPH.-For almost a century, transurethral resection of the prostate (TURP) has remained the "gold standard" for treating BPH. During the past de cade, considerable effort has been invested in attempts to devise a treatment modality that is as efficacious as TURP but associated with less morbidity. Prostatic balloon dilation was briefly advocated, but 6-month follow-up results have been disappointing." Transurethral incision of the prostate involves limited tissue resection, entails a short operative time, and is associated with minimal morbidity; however, it is recommended only for small prostates (less than 20 g),? Recently, medical therapy with use of 5a-reductase inhibi tors (finasteride) and aj-adrenergic antagonists (terazosin or prazosin hydrochloride) has been proposed, but a lifetime of patient compliance is necessary. Drawbacks of finasteride include delayed or minimal response (or both) and masking of prostate-specific antigen (PSA) levels for early detection of prostatic cancer." Headaches and dizziness from a j adrenergic antagonists have limited their use in some pa tients,? Currently, prostatic stents are under investigation and have been reported as a preferable alternative to a long term indwelling Foley catheter in debilitated patients with urinary retention.'? Promising results, decreased morbidity, and lower cost make VLAP a desirable alternative. Technique of VLAP.-Neodymium:yttrium-aluminum garnet (Nd:YAG) is the active medium used by most urolo


Coordinated development of urban and rural vocational education is an important part of coordinated de-velopment of urban and rural areas.Promoting the development of vocational education oriented towards rural ar-eas is an important act.Not only is it an internal demand of formating an good interaction relationship between ur-ban and rural vocational education,but also is the external representation for vocational education surving the con-struction of new socialist countryside.It mainly depends on the government to promote the development of voca-tional education oriented towards rural areas.To provide good policy environments for the development of vocation-al education oriented towards rural areas,the government should take some measures in admission policies,school-running policies,fiscal policies and teaching policies.


The purpose of this study is to investigate the effects of process parameters (tool diameters, wall angle and step size) on geometric accuracy during forming pyramid shape using computer numerical control (CNC) milling machine. Taguchi orthogonal array (L9) was used to design the experimental work and the results were analyzed using ANOVA package in Minitab 2017. The results shows that geometric accuracy increase as tool diameter and step size are decrease while it increase with wall angle increase. Two type of error was found sheet bending error (eb) and spring back error (es). Tool diameter have the highest effect on geometric accuracy followed by wall angle and step size.


Aims Duty of candour, the professional responsibility to be honest with patients when things go wrong, is not currently routine practice in the paediatric department of this tertiary referral hospital in Bhutan, despite a Ministry of Health initiative to improve accountability in the clinical setting. Reasons cited by the faculty include cultural differences and public perception. We sought to determine the attitudes towards duty of candour amongst healthcare professionals in this department. Methods We conducted a mixed-method quantitative and qualitative study using a semi-structured questionnaire. Convenience sampling targeted doctors and nurses working in four clinical areas: PICU, NICU, paediatric, and neonatal ward. Data were analysed in Epidata Stat software. We obtained ethical review exemption from the Research Ethics Board of Health of Bhutan. Results A total of 38 responses (26 nurses and 12 doctors) were collected. Ten respondents (26.3%) reported that the parent is usually informed following a medical error. Thirty-six respondents (94.7%) think the parent should be informed with 27 (71.1%) agreeing a consultant should offer an apology. There was no statistically significant difference between responses based on profession (doctors and nurses), gender or experience (less than or more than 5 years work experience). Table 1– Percentage of respondents agreeing with reasons for and against duty of candourAbstract G296(P) Table 1 Percentage of respondents agreeing with reasons for and against duty of candour Reasons For % Reasons Against % Maintain parental trust 97.4 Parental anxiety/stress 57.9 Obligation to be honest 86.8 Bhutanese culture 10.5 Parent's right to the truth 94.7 Fear of being blamed 47.4 Improve error reporting and patient safety 92.1 Hospital reputation 21.1 Difficult conversation 39.5 Conclusion This study shows that the majority of healthcare professionals in this department feel parents should be informed following an error and offered an apology. The most frequently reported barrier to duty of candour was causing parents anxiety or stress. Interestingly, only 10.5% identified cultural reasons as an obstacle. Further education and training using role-playing scenarios would be beneficial in increasing awareness and integrating duty of candour into existing quality assurance mechanisms.


To effectively solve the air strike likelihood,the concept "attack-vulnerability"of target was newly proposed to quantify it on the basis of the target value and selection theory.Furthermore,according to the secondary disaster risk assessment theory,a methodology was constructed for critical infrastructures under air strikes.Then a notional example about a petrochemical plant was provided to demonstrate the practicability and viability of the proposed assessment methodology.It has shown that the secondary disaster risk can be reduced obviously after taking risk mitigation factors into consideration;and that the risk assessment result can be useful for distributing defensive resources and making security management strategy.


Engineers involved in the evaluation, repair, and rehabilitation of concrete bridges have long had a need for nondestructive test methods which can provide information about the internal condition of a structure without the need to drill holes into the structure. The impact-echo method -- a versatile and powerful technique that can detect internal flaws in a wide variety of reinforced prestressed concrete bridges -- is rapidly becoming an extremely useful tool for engineers involved in condition assessment situations. This paper provides a brief explanation of the impact-echo method and describes a variety of case studies where the method has been used effectively for condition assessment of bridges.


Objective To study the curative effects of celecoxib combined with antitumor drugs on gliomas and its mechanism. Methods The human glioma cell lines U251 cells were cultured and they treated with celecoxib or temozolomide or both the drugs. The cell morphologic change was observed under the optical microscope. The proliferation of U251 cells was determined by methyl thiaszolyl tetrazoliu assay. The migration ability of U251 cells was determined by wound healing test. The apoptosis of U251 cells were evaluated by flow cytometry with PI-Annexin V staining. The expression of Bcl-2 and Bax in U251 cells were detected by western blot. Results The morphologic changes occurred in U251 cells treated with celecoxib or temozolomide or both the drugs, but the morphologic change in U251 cells treated by both the drugs were most significant. The inhibitory effect of celecoxib combined with temozolomide on U251 cells proliferation was significantly stronger than those of celecoxib or temozolomide (P0.01). The apoptosis rate in U251 cells treated by both the drugs was significantly higher than those in U251 cells treated by celecoxib or temozolomide alone (P0.01). The celecoxib combined with temozolomide more significantly inhibited the migration of U251 cells compared to celecoxib or temozolomide alone. The level of Bax expression was significantly higher and the level of Bcl-2 expression was significantly lower in U251 cells treated by both the drugs than those in U251 cells treated by celecoxib or temozolomide alone. Conclusion The combinative application of celecoxib and temozolomide can promote the apoptosis and inhibit the proliferation and migration of U251 cells in a synergistic manner. These effects of celecoxib combined with temozolomide may be related with the upregnlation of Bax expression and down regulation of Bcl-2 expression.


Report on Physics and technology in the fibres industry, Institute of Physics, Yorkshire Branch, 22 March 1979 at ICI Fibres, Harrogate, Yorkshire.


Abstract : Training and preparation are required in order to work successfully in another culture. A number of such training programs have been developed for this purpose. Some of them, like Foreign Service or Peace Corps training, require several months; others, such as those in some business organizations, involve orientation courses of several weeks. There is, however, also a need for the type of orientation which can be compressed into the space of a few hours. The need for such a program is particularly acute for the officer who suddenly finds himself en route to a foreign assignment, or for the government official or business executive who simply cannot spare the weeks or months to prepare himself for each and every culture within which he must perform effectively. An attempt was made to develop a culture training program which would provide the individual some familiarity with the host culture within the space of hours--if necessary on the plane to his destination.


financial information in schools. Payment information which is the basis for schools to determine future policies. The object of research in this thesis is the Demak Development High School which is one of the agencies engaged in the field of science and education.
The research objective is to design an effective and efficient school payment administration recording information system and design a school payment administration recording information system that has a system security that can maintain the accuracy of the data. The research method used is the Borg and Gall R&D Development Research model, the Prototyping System Development Method to produce a product in the form of a Prototype with 6 stages: Research and Data Collection, Planning, Initial Product Development, Product Testing, Product Revision, Final Trial.
The conclusion from the results of this study is that this system can facilitate the recording of administrative payment transactions so that there are no mistakes in recording, users can easily present payment reports more quickly so that they can minimize recording time and recording errors, and make it easier for users to print payment reports with affectic and efficient results so as to support and accelerate decision making


The city of Sibay of the Republic of Bashkortostan is young, which began construction in the days of strengthened socialism; and there are no events that affected most of the mosques in the villages of Baimaksky district, such as secularization, the liquidation of the Muslim community, mosques and the confiscation of its religious property. The history of the first mosque is connected with the history of the city, since it was originally formed in the Soviet years as a result of the industrialization of the Soviet Union, and there was no need to talk about mosques in those years. But times of change came and almost all the villages of the Bashkir Trans-Urals acquired their own mosques. The Bashkirs and Tatars who settled in this area and became the reason for the appearance of our city were ethnic Muslims. In the city of Sibay, a mosque and an Orthodox church were being built at the same time. One of the features of the end of the last century is that the population recognized a certain positive significance of religion, especially in the field of the moral education of the young.