The rotating disk is a basic machine part that is u sed widely in industry. The motion equation is transformed into the dynamic equa tion in real modal space. The personating intelligent integration is introduced to improve the existing control method. These modes that affect the transverse v ibration mainly are included to simulate the vibration of rotating disk, and two methods are applied separately on condition that the sensor and the ac tuator are collocated and non-collocated. The results obtained by all-sided si mulations show that the new method can obtain better control effect, especially when the sensor and the actuator are non-collocated.


Significance Protein O-glycosylation is an important process in all cells. Substrates are often modified at multiple Ser/Thr residues, but how a glycosyltransferase can act on a continuously changing substrate is unknown. Here, we have analyzed the mechanism by which the cytosolic O-glycosyltransferase GtfA/B of Streptococcus gordonii modifies the Ser/Thr-rich repeats of adhesin, a protein that mediates the attachment of the bacterium to host cells. GtfA/B is a tetramer, with two molecules of GtfA and GtfB. The GtfB subunit of the glycosyltransferase provides the primary polypeptide-binding site, whereas GtfA performs catalysis. GtfB binds unmodified substrate when conformationally constrained by GtfA and binds modified adhesin molecules when in a relaxed conformation. This model explains how the glycosyltransferase can modify a progressively changing substrate molecule. O-glycosylation of Ser and Thr residues is an important process in all organisms, which is only poorly understood. Such modification is required for the export and function of adhesin proteins that mediate the attachment of pathogenic Gram-positive bacteria to host cells. Here, we have analyzed the mechanism by which the cytosolic O-glycosyltransferase GtfA/B of Streptococcus gordonii modifies the Ser/Thr-rich repeats of adhesin. The enzyme is a tetramer containing two molecules each of GtfA and GtfB. The two subunits have the same fold, but only GtfA contains an active site, whereas GtfB provides the primary binding site for adhesin. During a first phase of glycosylation, the conformation of GtfB is restrained by GtfA to bind substrate with unmodified Ser/Thr residues. In a slow second phase, GtfB recognizes residues that are already modified with N-acetylglucosamine, likely by converting into a relaxed conformation in which one interface with GtfA is broken. These results explain how the glycosyltransferase modifies a progressively changing substrate molecule.


To memoirs and soldiers' letters, the new military historian must add soldier newspapers as a rich and useful source for understanding the fears and hopes of the troops of all ranks. By analysing the production and creation of these newspapers for the British, French, and German armies in the First World War, and indicating both the unique national traits of each nation's journals and the universal stories found across the three armies' newspapers, it is hoped that this article will point researchers toward the vast archive of soldier newspapers available for many of the wars of the last 250 years.


Technology provides ample opportunities for students to develop academically and gain easy access to education through online learning systems, especially in pandemic situations where in-class arrangements are restricted. However, one of the most challenging aspects of online learning is being aware of and supportive of students' emotional needs. This is because emotions play a crucial role in predicting student learning levels. In a traditional in-class setup, educators can easily recognize a student's emotions and adjust their teaching methods accordingly to match the students' learning levels. However, the same is much more challenging in an online environment as the available online meeting tools do not include emotion detection as part of their product due to various factors, such as technical limitations and the complexity of accurately detecting emotions through an online interface. Therefore, this work proposes a realtime student emotion detection system in an online education environment to change the delivery methods accordingly. First, we identify the five most influential emotions in an education environment: boredom, anxiety, enjoyment, anger, and surprise, based on the analysis of the literature. Then, we propose a CNN-based facial emotion recognition system based on these five emotions. To design and test the model, we designed a dataset based on images captured in a real university online learning setup and merged it with publicly available DAiSEE and FER 2013 datasets. Finally, we evaluate the model's performance based on classification accuracy, precision, recall, and other standard metrics. The model shows 96.70% accuracy in learner categorization, which is a significant increase in performance compared to the existing literature.


Abstract A skill forecast gives the probability distribution for the error in a forecast. Statistically, Well-founded skill forecasting methods have so far only been applied within the context of simple models. In this paper, the growth of analysis errors is studied. This means that errors that are already present in the estimate of the initial state can grow only in accordance with the dynamics of a model. Errors in the description of the model itself are neglected. This paper uses a three-level quasigeotrophic spectral model of the atmospheric circulation, truncated at T21. It is shown that a linear theory for the evolution of errors can be used for the first three days of a forecast. For the description of the global error, Monte Carlo methods are more efficient that methods based on the use of the adjoint of the tangent linear equations. The limitation to spatially local errors dramatically reduces the dimension of the error vector. In that case, adjoins methods are the most efficient ones. Local skil...


Cech cohomology $H^n(X)$ of a separable metrizable space $X$ is defined in terms of cohomology of its nerves (or ANR neighborhoods) $P_\beta$ whereas Steenrod-Sitnikov homology $H_n(X)$ is defined in terms of homology of compact subsets $K_\alpha\subset X$.
We show that one can also go vice versa: in a sense, $H^n(X)$ can be reconstructed from $H^n(K_\alpha)$, and if $X$ is finite dimensional, $H_n(X)$ can be reconstructed from $H_n(P_\beta)$.
The reconstruction is via a Bousfield-Kan/Araki-Yoshimura type spectral sequence, except that the derived limits have to be "corrected" so as to take into account a natural topology on the indexing set. The corrected derived limits coincide with the usual ones when the topology is discrete, and in general are applied not to an inverse system but to a "partially ordered sheaf".
The "correction" of the derived limit functors in turn involves constructing a "correct" (metrizable) topology on the order complex $|P|$ of a partially ordered metrizable space $P$ (such as the hyperspace $K(X)$ of nonempty compact subsets of $X$ with the Hausdorff metric). It turns out that three natural approaches (by using the space of measurable functions, the space of probability measures, or the usual embedding $K(X)\to C(X;\mathbb R)$) all lead to the same topology on $|P|$.


Background: The study aimed to compare the effectiveness of curcumin 0.5% and 5% by Natrium Chloride (NaCl) 0.9% in the acute wound healing of mice. Methods: This study was conducted at the Animal Laboratory and at the Department of Anatomical Pathology, Medical Faculty Hasanuddin University in Makassar, by using an experimental study. The samples consisted of 30 mice observed by the change of clinical and histopathological manifestations. Result: The study reveal that there was no significant difference between the application of curcumin 5% and Natrium Chloride 0.9% in the healing wound. After seven days the length of significant reepithelization was p=0.026 between curcumin 0.5% and Natrium Chloride 0.9%. After the seventh day of treatment the density of polymorpho nuclear (PMN) and macrophages was not significant (p<0.05) in all three groups. Statistically, the thickness of fibroblast was significant, between Natrium Chloride 0.9% and curcumin 0.5% (p=0.049), curcumin 5% (p=0.006) after the treatment on day seven. Conclusions: The use of application topical curcumin is not better than the NaCl 0.9% in acute wound healing in mice.


Background: Movement disorders and non-motor problems such as cognitive decline, anxiety, depression and behavioural problems, are common in people with dementia and can progress over time. Exercise coupled with music is a promising form of therapy designed to improve both the motor and non-motor manifestations of this debilitating neurological condition. Objectives: To present a protocol for a systematic review and critical analysis of the literature to answer the following questions: (i) Is music-cued exercise more effective than usual care for the treatment of motor and non-motor symptoms of dementia? (ii) What are the outcomes of music-cued exercise for people living with dementia? Methods: We provide the protocol for a systematic review and critical analysis of the literature using the PRISMA guidelines. Studies shall be reviewed that use music cued exercises aimed at improving the management of physical and non-physical problems associated with dementia. Eligibility criteria will be applied to the title and abstract of each citation as a first step followed by full text screening. Data extraction and quality appraisal are to be performed by two reviewers. Data sources: This protocol documents the comprehensive search strategy to be performed using MEDLINE, CINAHL, EMBASE, PSYCHINFO, PUBMED, SCOPUS and web of science databases. Science, technology and engineering databases will also be searched. Eligibility criteria: All study designs incorporating data will be included in this review. The following selection criteria shall be applied: • Participants will be people diagnosed with dementia, including Alzheimer's disease, of any stage and severity, all ages, any range of co-morbidities, any medications. • Interventions will use rhythmic music with any physical exercise or rehabilitation program. • Outcomes shall include motor impairments such as gait, postural stability and general mobility. Studies considering non-motor signs such as anxiety, depression, behavioural disturbances and cognitive decline will also be included. Results: Evidence will be built from this review regarding the effectiveness of using music-cued exercises to optimise physical abilities and improve non-motor disorders in people with dementia. Conclusions: This protocol paper documents the methods that we shall use for a forthcoming systematic review. The knowledge obtained from the review will provide guidance to people with dementia, caregivers and clinicians by clarifying the strength of the evidence for music-cued movement rehabilitation.


Let N be a near-ring and I be an ideal of N. The graph of N with respect to I is a graph with V (N ) as vertex set and any two distinct vertices x and y are adjacent if and only if xNy ⊆ I oryNx ⊆ I. This graph is denoted by GI(N). We define the line graph of GI(N) as a graph with each edge of GI (N ) as vertex and any two distinct vertices are adjacent if and only if their corresponding edges share a common vertex in the graph GI (N ). We denote this graph by L(GI (N )). We have discussed the diameter, girth, clique number, dominating set of L(GI(N)). We have also found conditions for the graph L(GI(N)) to be acycle graph.


Wasteform phase assemblages and radionuclide immobilization are described for a Synroc-D bulk composition processed at 1200/sup 0/C under oxygen fugacities (fO/sub 2/) ranging from air to those approximating graphite-CO-CO/sub 2/ buffer. All processing conditions produce assemblages of titanate and aluminate crystalline phases plus alkali aluminosilicate glass. In all cases the important radionuclides are immobilized in crystalline phases which have been shown to be highly leach-resistant.


In this paper,the polynomial type of Hamilton system is considered.Using Wu elimination method,a new algorithm is given to determine the system regularity.For regular systems,the Hamiltonian and motion equations are obtained.For degenerate systems,two new algorithms are given to solve the constraints,and the constrained Hamiltonian and constrained motion equations are obtained.These algorithms can be executed in symbolic computation software platform.


Abstract The present investigation was conducted on guava cv. Lalit spaced at 2 m × 1.5 m in meadow plant-soil interface during two consecutive rainy seasons of 2017 and 2018. Foliar application of humic acid was carried out at bud burst stage in two different levels i.e. 30 ml/L (HA30) and 60 ml/L (HA60), bio-inoculants were applied to the rhizosphere of the trees at two combinations, B1: PSB @ 10 ml/plant + Azotobacter chroococcum @ 10 g/plant, and B2: PGPR @ 25 ml/plant + AM fungi @ 25 g/plant along with reduced recommended dose of fertilizers (RDF) of N:P:K (360:740:200) i.e. 90 per cent of RDF (NPK90) and 80 per cent of RDF (NPK80). The experiment was laid out in Randomized Complete Block Design with eight treatment combinations, replicated thrice along with a control. The results showed that application of humic acid at 60 ml/L along with each of PSB and A. chroococcum at 10 ml/plant along with 80 per cent of NPK resulted in growth and fruiting over control. This combination also recorded significant increase in fruit set with marked reduction in fruit drop. Fruit yield was 1.89 times compared to control. Both physical and biochemical fruit quality traits were also significantly affected by this conjoint application. Microbial biomass in terms of actinomycetes, A. chroococcum, PSB and AM fungi were also tremendously increased compared to control. This combination also exhibited considerably greater amount of leaf N (2.55%), leaf P (0.24%) and leaf K (1.32%) under meadow plant-soil interface.


In this paper, we present an active rectifier with high power conversion efficiency (PCE) implemented in a 0.5- mum 5 V standard CMOS process with two modes of built-in back telemetry; short- and open-circuit. As a rectifier, it ensures a PCE > 80%, taking advantage of active synchronous rectification technique in the frequency range of 0.125 - 1 MHz. The built-in complementary back telemetry feature in this rectifier can be utilized in implantable microelectronic devices, radio frequency identification (RFID), and wireless sensor applications to reduce the silicon area, improve the reading range, and increase the data rate with load shift keying (LSK).


Two contradiction of nature Theory of Mao Zedong about correct dealing with two kinds of contradiction of different nature, it paid attention to dealing with the existing contradiction.Deng Xiaoping paid move attention to removing and reducing the existent objective conditions and mechanisms of China's social contradiction and thought system construction as fundamentality approach of solving contradiction. Thereby, Deng Xiaoping developed Mao Zedong Thought.


Few concepts have been more controversial, important and misunderstood than the "least restrictive environment principle." The author explores the history of the concept, particularly as it relates to the design and provision of educational programs to children and youth with disabilities. This historical account traces its origins to several legal cases, to the writings of numerous special education leader over a period of four decades, and to the more recent normalization principle. Next, the author examines, from both psychoeducational and sociopolitical perspectives, the controversial question, "Why integrate?" The discussion includes a review of recent research on attitudes toward disabilities, curriculum for severly and profoundly disabled students, the political meaning of integration, the economics of integrated schooling, program innovations, and parent/community responses to integration. Finally, the author identifies seven factors which can facilitate or impede application of the least restrict...


Doping ZnS nanoparticles with different metal and/or non-metal ions is one of the ways to improve their properties. That is because dopants introduce strain into the lattice of the ZnS nanoparticles. The influence of Ti on the ZnS nanoparticles was investigated on the structural properties, optical properties, and also electrical impedance spectroscopy (EIS). The presence of Ti in the crystal lattice of the ZnS introduced strain into the crystal structure, hence causing a lattice expansion and reducing the crystallite sizes of the ZnS nanoparticles. Ti doping was observed to increase the energy band gap of ZnS nanoparticles and also reduce the charge carrier recombination. Doping Ti into ZnS was observed to decrease the charge transfer resistance of ZnS nanoparticles with an increase in dopant concentration indicating an improved charge transfer mobility owing to the presence of strain in the crystal lattice.


The ecology environment problem belongs to morality. The environmental morality is the rule which can readjust the interests relationships in ecology environment between person and person, or people and society. For standardzing the relationship between human and environment, it is necessary to enhance the environmental morality education and foster people's environmental morality.


The main goal of the article is to compare a computational efficiency of different implementation of a hyperelastic material model in the ABAQUS/Standard v. 6.14 [1]. The software offers basically two ways to proceed, namely UMAT and UHYPER user subroutines [2]. The procedures are employed to implement an isotropic, compressible neoHookean material model [3]. Corresponding stored-energy function, constitutive equations and the consistent tangent operator are presented. These are essential to program the subroutines. Some theoretical and numerical aspects of different implementation approaches are discussed. As examples, a tube under axial compression and a contact problem of disc are considered. On the basis of obtained results, selected aspects of computational efficiency and quality of solutions are compared.


Abstract Introduction Severe eosinophilic asthma (SEA) is associated with multiple exacerbations. Fractional exhaled nitric oxide (FeNO), a biomarker of airway T2 inflammation, is known to be correlated with the risk of exacerbations. While the use of FeNO is well established to predict the therapeutic response to dupilumab (anti-IL-4/IL-13), it remains uncertain for biologics targeting the IL-5 pathway. Methods We conducted an observational, retrospective, monocentric analysis of adults with SEA who started mepolizumab (anti-IL-5) or benralizumab (anti-IL-5R) between January 1, 2016 and December 31, 2020. Results Data were collected for 109 patients. All participants reported uncontrolled asthma with a median of 3 annual exacerbations and a median Asthma Control Test score of 12. They all had an initial blood eosinophilia >300/mm3, with a median at 610/mm3 (IQR 420-856). Patients with a baseline FeNO ≥50 ppb reported more exacerbations in the previous year than those with a FeNO <50 ppb (p = 0.02). After initiation of treatment, change in FeNO was not associated with therapeutic response. However, decrease in the annual number of exacerbations was significantly greater in patients with a baseline FeNO ≥50 ppb than in those with a baseline FeNO <50 ppb (-3.3 ± 2.7 vs −0.9 ± 2.4, respectively; p = 0.01). There was no association between baseline FeNO values and subsequent lung function, asthma control or reduction of oral corticosteroids use. Conclusion In this real-world cohort, adults with SEA who had a baseline FeNO ≥50 ppb experienced a greater decrease in exacerbations after 12 months of anti-IL-5 or IL-5R biologics than those with a FeNO <50 ppb.


The promotion of mother tongue language has become a pressing concern for many countries and their educational institutions. This study aims to identify the requirements and obstacles to enhancing mother tongue language proficiency among higher education students, as perceived by faculty members. The study adopted a descriptive approach and administered a questionnaire to the study population.The study findings indicate that the requirements to activate the role of higher education institutions in enhancing mother tongue proficiency among students, as perceived by all faculty members, are substantial. Financial requirements were identified as the most crucial, followed by organizational, academic, and human requirements. Human obstacles, such as students' tendency to converse in a mix of mother tongue and foreign languages, were found to be among the most significant hurdles facing the promotion of mother tongue language in higher education institutions. Organizational, academic, and financial obstacles were also identified as significant and were found to be at a high level.


Abstract Seed shape in the Malvaceae and other families of the order Malvales was investigated. Seed shape was quantified by comparison with the cardioid. The J index is the percent similarity between both images, the seed and the cardioid, and similarity is considered in cases where the J index is over 90. Seed shape was analysed in 73 genera, and seeds resembling the cardioid were found in 10 genera, eight in the Malvaceae and two in the Bixaceae and Cistaceae. Seed shape was quantified by comparison with the cardioid in 105 species. A correlation was found between the values of the J index and plant form, with higher values of the J index in the seeds of herbs, intermediate – in bushes, and lower values in trees. The results suggest a relationship between seed shape and plant form, where seeds resembling the cardioid are associated with plants having small size.


According to Law of Conservation of Energy,a dynamic model is established to analyze the thermal and electrical performance of a combined parabolic concentrator-photovoltaic/thermal(CPC-PV/T) system.The influence of some factors such as the dimension of the CPC-PV/T system,the water mass flow rate and etc.,on the performance of CPC-PV/T system are investigated.When the water mass flow rate is constant,the daily electrical and thermal efficiency is decreased along with the increase of the length of the CPC-PV/T system.When the length of the system is constant,the temperature of water is decreased along with the increase of the water mass flow rate,the system electrical efficiency is increased.However,with the increase of the water mass flow rate,the variations in temperature of water and system electrical efficiency are decreased.There is an optimum relationship between the system electrical efficiency and the temperature of water based on the water mass flow rate.


Objective: To identify and characterize the key symptoms and clinical impacts associated with transitioning from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive multiple sclerosis (SPMS).
 Background: These results support the development of a screening tool to assist physicians in timely SPMS diagnosis.
 Methods: In-depth, open-ended, qualitative interviews were conducted face-to-face with 32 MS patients in the US and Germany (RRMS/SPMS, n=16 each). Semi-structured qualitative telephone interviews were also conducted with MS physicians (8 per country) to explore the clinical relevance of proposed tool items based on their experience in SPMS. A full written transcript of each interview was analyzed using Atlas Ti software.
 Results: Physicians considered gradual worsening of symptoms (13/16), lack of clear recovery (10/16), increased severity (9/16) and presence of new symptoms (9/16) to be most associated with progression to SPMS. Presence of new lesions on MRI (8/16) and absence of clear relapse (7/16) were also considered in SPMS diagnosis. According to physicians, symptom worsening was driven by domains of vision, cognition, balance and ambulation. Time to confirmation of SPMS diagnosis varied from 1.5 years (4/16). Key challenges in SPMS diagnosis included lack of treatment options (10/16) and inability to detect changes due to SPMS onset (6/16). Compared to RRMS, more SPMS patients rated their health as poor (n[[percnt]]: 3[19] vs. 1[6]) and MS as severe (5[31] vs. 1[6]).13 of 16 SPMS patients stated that subjective worsening of symptoms during the progression from RRMS to SPMS was driven by ambulation (10/16), muscle weakness (8/16) and vision (5/16).
 Conclusions: Clinicians found it challenging to confirm diagnosis of SPMS and considered a broader range of factors in making this diagnosis. Patients experienced a range of symptoms, but no symptoms were specific to RRMS/SPMS. Development of prognostic tool for timely SPMS diagnosis was considered useful for the clinical practice.
Funding:Novartis Pharma AG Disclosure: Dr. Ziemssen has received personal compensation for activities with Bayer Schering Pharma, Biogen Idec, EMD Merck Serono, Genentech, Genzyme, Novartis, Sanofi-Aventis, Teva Pharmaceutical, and Almirall. Dr. Bennett has received research support from various commercial entities. Dr. Tolley has received research support from various commercial entities. Ms. Kilgariff received research support from various commercial entities. Dr. Simsek has received personal compensation for activities with Novartis as an employee. Dr. Lahoz has received personal compensation for activities with Novartis as an employee. Dr. Verdun has received personal compensation for activities with Novartis as an employee.


We investigate the magnetic-field-orientation dependent magnetoelectric (ME) effect in the FeBSiC/Pb(Zr,Ti)O3(PZT)/FeBSiC laminates. It is shown that, by only using the bias-magnetic-field dependent ME response measured with the magnetic-field parallel to the surface plane of PZT slab, the magnetic-field-orientation dependent ME coefficient upon magnetic-fields of various amplitudes can be obtained via computer simulations. The simulation results match well the experimental measurements, demonstrating the applicability of the ME laminates-based sensors in detecting magnetic-fields with uncertain amplitudes and/or orientations in environment.


A large‐aperture planar array has been constructed for an indirect sensing of the vertical oceanic density fine structure distribution. The array is approximately 14 m square and consists of 128 hydrophones arranged in a horizontal plane around an 8‐kW sound source. Operating frequencies are from 2 to 20 kHz; pulse durations are from 12 to 1 msec. The array is towed to sea, submerged to a depth of 20 m, and suspended from R/P ORB (Oceanographic Research Buoy). A spring compression system decouples array motion from the motion of the surface support vessel for vertical excursions of up to 3 m. The back‐scattered energy from each transmission is clipped and digitized in 1024 depth intervals, covering approximately the upper 400 m of the water colume. Beamforming of the information at each depth interval allows discrimination between specular reflectors and point scatterers. [This research is supported by the Advanced Research Projects Agency.]


This study investigates the influence of masculine ideology on fathers and sons in the modern American play, True West by Sam Shepard. When approaching this American traditional family drama, it is revealed how the father's masculinity touches the emotions of the sons' masculinity. A father figure is influential on male characters in settling their masculinity. In this play, the absence of the father can lead his sons to conflict while establishing their identities of manhood. Although this limited example cannot be viewed as reliably representative of all cases in American Drama, it is interesting to note that masculinity seems to become more problematic in the work, offering us visions of ways that masculinity is rigidly constructed and how it is problematic within American society.


Leadership in Family Medicine/ Primary Health Care, including training of postgraduates in this discipline, is essential to favorably impact training, as well as patient related health care outcomes. In the Eastern province of Saudi Arabia, a step model leadership approach has been utilized to achieve targets set for training of postgraduates in Family Medicine training program, in same time it also has been utilized in the primary mental health program in Eastern Province-MOH. Step model leadership initiative is a transformational leadership that involves three steps. Step one essentially is based on a managerial role where tasks are assigned for the team and desired outcomes agreed at the start of the program. Step two is role model stage that ensures progression of the task. Step three is essentially an evaluator type of leadership role that tries to establish and mentain the continiuouty of achieving the desired outcomes, it utilizes advocacy as one of its main strategies. It is important that one in a leadership position in this step model understands their role and contributes effectively in line with the expectations of the step model for leadership initiative. This Step Model for leadership has been successfully applied in the training of postgraduates in Family Medicine Program in Eastern province, MOH of Saudi Arabia. It is proposed that it should be applied throughout Saudi Arabia and in other countries of the region.


MPEG-4 High-Definition Advanced Audio Coding (HD-AAC) enables scalable-to-lossless (SLS) audio coding with an Advanced Audio Coding (AAC) base layer, and fine-grained enhancements based on the MPEG SLS standard. While the AAC core offers better perceptual quality at lossy bit-rates, its inclusion has been observed to compromise the ultimate lossless compression performance as compared to the SLS 'non-core' (i.e., without an AAC base layer) codec. In contrast, the latter provides excellent lossless compression but with significantly degraded audio quality at low bit-rates. We propose a trellis-based approach to directly optimize the trade-off between the quality of the AAC core and the lossless compression performance of SLS. Simulations to test the effectiveness of the approach demonstrate the capability to adjust the trade-off to match application specific needs. Moreover, such optimization can in fact achieve an AAC core of superior perceptual quality while maintaining state-of-the-art (and surprisingly sometimes even better) lossless compression, all this in compliance with the HD-AAC standard.


A discussion of the position of the languages,which are endangered,in linguistic science,defining the principle indexes for determining the endangered languages,and some problems in the study of the endangered languages.


MATERIALS and METHODS: Fifty-four sudden sensorineural hearing loss (SSNHL) patients, admitted to our hospital between January 2012 and April 2013, were enrolled as the study subjects. Based on the specialists' clinical experience, 27 patients received full-dose prednisolone (Group I). The other 27 received a tapering dose of prednisolone (Group II). We analyzed the efficacy of the two management groups by assessing the patients' hearing recovery after 6 months of treatment.


Three agricultural products, carrot, broccoli and potato tissue, were osmotically dehydrated by immersion in 50% (w/w) sucrose solution and their rheological properties were measured before and after freezing-thawing-rehydration. Although the dynamic elasticity and viscosity became smaller after freezing-thawing as compared to the fresh sample, the osmotically dehydrated sample showed much higher retention of rheological properties than the untreated sample with the exception of the potato sample. In measurement of complex impedance, the radius of the Cole-Cole arc, an index of the intactness of cell plasma membrane, showed good correlations with the rheological properties for carrot and broccoli. The amount of drip from the cell tissue was also compared among various treatments. The osmotically dehydrated sample showed much less drip than the untreated sample after freezing-thawing-rehydration. Under an optical microscope, the cell structure seemed to show less injury for the osmotically dehydrated sample than the untreated sample. These results indicate that osmotic dehydrofreezing protects the cell structure, in particular the cell plasma membrane, against freezing injury to give reduced softening after freezing-thawing.


The E2F1 transcription factor can initiate proliferation or apoptosis, the latter by both transcription‐dependent and ‐independent mechanisms. Recently, an E2F1 mutant lacking the DNA binding domain, E2F1(180–437), has been implicated in degradation of MDMX and MDM2 proteins via lysosomal proteases. MDM proteins block p53 dependent apoptosis by directly inhibiting p53 stability and function. Here we demonstrate E2F1(180–437) induces death in HEK293 cells independent of E2F1 transcriptional activation and p53 stabilization. E2F1(180–437) elevates the activity of the calcium‐activated protease, calpain, which is required for E2F1 induced proteolysis of MDMX and E2F1 induced cell loss. To determine if E2F1 could be activating proteolysis via calpains in neurodegeneration, we examined MDMX immunofluorescence in simian immunodeficiency virus encephalitis (SIVE). We found a reciprocal relationship between E2F1 and MDMX staining: in SIVE where E2F1 immunostaining is increased, MDMX is decreased, while in controls where E2F1 immunostaining is low, MDMX is high. Together these experiments support a new function for E2F1 in the activation of calpain proteases and suggest a role for this pathway in SIVE. © 2005 Wiley‐Liss, Inc.


A comparative study of the magnetocaloric effect (MCE) in metals within the single-band Hubbard model on the face-centered cubic (fcc) lattice using both mean-field (Stoner) approximation (MFA) and dynamical mean-field theory (DMFT) is done. The MCE is investigated in the case of second order magnetic phase transition from ferromagnet to paramagnet. To ensure presence of itinerant ferromagnetism in the Hubbard model the special case of spectrum parameters generating giant van Hove singularity at the bottom of the band is considered, while the Fermi level Ef is in the vinicity of the band bottom. To compare MCE within MFA and DMFT temperature dependence of magnetization, total energy and finally entropy for a set of Coulomb interactions U at zero and finite values of magnetic field h for both methods were performed. Also one of the MCE potentials, isothermal entropy change, as a function of temperature ∆S(T) for both MFA and DMFT is calculated. In the MFA, the expected maximum value of ∆S(T) at the Curie temperature TC (∆Smax) quite significantly decreases while U grows. Similar but much weaker decreasing of ∆Smax is found for DMFT results. The account of local quantum fluctuations results in larger values of ∆Smax within DMFT than within MFA. A peak width of ∆S(T) at half height is approximately the same for both methods. Another effect of DMFT local quantum fluctuations is the destruction of anomalous Curie temperature TC dependence on U present in MFA, which is invoked by an effect of giant van Hove singularity. However the relative cooling power (RCP) is very close in DMFT and MFA for the same model parameters and goes down upon U increase.


We have teamed up with Tilde Records and Q-PUP, a solo lo-fi / indie / folk / experimental act from Minneapolis, to give you his new mystical music ...


Recently, studies on HVDC circuit breaker (CB) prototypes have become popular among power system researchers. In this paper, a novel hybrid-type superconducting DCCB model (SDCCB) is proposed. The SDCCB has a superconducting fault current limiter (SFCL) located in the main line, to limit the fault current. After the trip signal, Electronic (IGBT) switches located in the main line will commutate the fault current into a parallel line, where dc current is forced to zero by combination of IGBTs and surge arresters. To check performance of the SDCCB, a simulation analysis for SDCCB current interruption performance is done in MATLAB software for three different systems which are denoted as "Normal System," "Strong System," and "Very Strong System". The current limiting by the SFCL notably suppressed the dc fault current and significantly reduced the current interruption stress for SDCCB components.


Characteristics of a gas-liquid annular jet which employs gas passing through a pipe at the center of a nuzzle are investigated. That is, the power spectrum of which component in high frequency region is bigger than that of a normal jet, volume flowrate quality, and pressure distributions of the jet of which bubbles exist over the cross section are analyzed. Abrasives can be mixed homogeneously in the annular jet through the inner pipe and collide with the impinging plate. The annular jet has excellent characteristics and hence is effective in use of erosion or washing.


Hearing losses are one of the most common impairments of old age. Reduction of auditory efficiency, which is a normal age change, may affect self-confidence and interpersonal relationships and interfere with the daily living activities of older persons. This article discusses changes which can be made by the hearing impaired person, by those communicating with the hearing impaired individual, and in the environment to compensate for decreased hearing.


Evaluation of the level of Artificial Intelligence (AI) readiness using the AI Readiness Index (AIRI) framework developed by AI Singapore (AISG) is needed for ministries in Indonesia to evaluate the level of readiness for the adoption and implementation of Artificial Intelligence (AI) technology and provide recommendations from the results of the assessment conducted in the government institutions, especially for the Ministry of Communication and Informatics, and the Ministry of Finance using the AI Readiness Index (AIRI) Framework so that an optimal and objective analysis can be carried out on the causes of the lagging adoption and implementation of Artificial Intelligence (AI) technology in Indonesia. The analysis was conducted both descriptively and comparatively. Descriptive analysis is carried out on the assessment results displayed by the AI Readiness Index (AIRI) Framework, Comparative analysis is carried out on the assessment results of the AI Readiness Index (AIRI) Framework of government agencies with industries engaged in the same field, not only that but also compared with other government agencies. The results showed that the Ministry of Communication and Informatics scored 2.9 as aware of adopting and implementing AI so that the Ministry of Communication and Informatics can prepare the organization to adopt AI, while the Ministry of Finance scored 3.64 as ready to implement and implement AI so that the Ministry of Finance can help the organization to adopt AI solutions.


Detection principle of tension sensor for diamond string bead wire is introduced. Its calibration is carried out. Analysis of sensor performance shows that it can meet the design requirement. Its main specification includes: the measurement range is 0~3000N, the accuracy is less than 0.5% FS, the non- linearity is less than 0.2% FS, the delay is less than 0.01% FS; and the repetition is less than 0.05% FS. The tension sensor can accurately and reliably measure tension of diamond string bead wire. Thus, working process of diamond wire saw can be controlled according to tension condition of string bead wire, and it is favorable to improve efficiency of diamond wire saw. The sensor has good waterproof and shockproof capability, so it can safely and stably work under water.


Variation within communication systems can be examined at several levels: variation among individual notes, variation in the arrangement of notes, and variation in delivery. Here, variation in the arrangement and delivery of notes used in female red-winged-blackbird vocalizations is described, and this variation is examined for correlations with the context in which the vocalizations were given. Within a vocalization, notes were normally arranged in a series of similar notes. Of the 75 different note arrangements recorded from the population, 12 arrangements accounted for 84 % of vocalizations. Provisional results indicate that the arrangement of notes was influence by the following contexts: 1. The stage of the breeding season; 2. The individual female; 3. The breeding status of the female; 4. Certain female behaviour patterns; 5. Other red-winged-blackbird vocalizations; and 6. The presence or absence of a female's mate in the territory. Variation in delivery was measured by the number of notes within a vocalization; delivery was influenced by the stage of the breeding season, the individual female, and the breeding status of a female. Most note arrangements were used in a wide variety of contexts and did not appear to be functionally distinct.


Results of research carried out on a waste rockwool and ammonium nitrate mixtures to examine the possibility of using them in fertilization of plants were presented. Reactions occurring between compounds were analyzed to determine the possibility of an uncontrolled exothermic decomposition of nitrogen fertilizer additive. Results obtained from the analysis of prepared mixtures in various proportions and separate samples of individual compounds were compared. Ammonium nitrate used in the research was supplied by one of the domestic fertilizers producer and waste rockwool was collected after a completed crop cycle of a tomato plant. Each sample was dried and ground before examination. Analysis was carried out using differential thermal analysis coupled with thermogravimetry and mass spectrometry (DTA-TG-MS). Obtained results indicate a possibility of use of rockwool mixed with ammonium nitrate in agriculture. However, it is important to choose optimal proportions of compounds to ensure the thermal stability of the mixture.


— Using property ( E.A .) and its variants, we prove some common fixed point theorems for quadruple of weakly compatible self maps in metric space in this paper. Our results extend and unify various known results in literature. We also give application of proved result for four finite families of maps.


This paper reports the results of a survey of 415 Muslims of UEMOA region retail consumers inJune 2014 -June 2015used in gathering attitudes, perceptions and motivations towards Islamic methods of finance.The focal point of Islamic banking is adhering to the shariah law which prohibits the utilization of Riba(interest). This banking approach has recently grown in popularity not only in Islamiccountries, but has been embryonic in non-Muslim countries. Although these methods are nottotally new or revolutionary as it has been written and practiced during the renaissance of the Islamic civilization, it has yet to establish itself and be a test in the modern world as compared to the conventional banking.There are many reasons why Muslims still engage in « non-interest-free » products. One of the reasons is the availability of Islamic financial product or non-interest bearing financial instruments offers by the banks, it is quite difficult to find such instruments, as most of themare not easy to get. To some extent,there are only few financial institutions which offer such products. This article attempts to examine the attitude of UEMOA Muslims, towardsIslamic finance products and will explain whether there is demand for such products from them.It is found out that Muslims living in UEMOAare very much willing to change their practices from indulging in the conventional system – the Islamic financial system. The results indicate that while most respondents have at least some knowledge about some aspects of Islamic finance, specifically full-equity business partnerships and (interest-free benevolent loans, they are generally unaware of many other related products. Nonetheless, most respondents (78.55%) are potential users of Islamic methods of finance at the retail level, though potential use varying markedly according to age, and level of education.


In this paper, we propose a method of extracting and tracking regions of human face and hands appeared on sequential images considering fusion of color information and tracking region. Conventionally, it has been hard to extract the skin regions of human in the case when a background reflects skin color objects like corrugated cardboards, or including moving picture such as TV screen. Coping with such kind of difficult situation to extract skin regions, we firstly obtain three kinds of information based on background color, skin color and its tracking skin regions, then apply Dempster-Shafer's combination rule to the three kinds of information. This approach using the fused information becomes a robust extraction method, because other information can extract the regions even if one of the information lacks. The effectiveness of our approach is examined by the experiments.


At present, Wireless Local Area Networks (WLANs) supporting broadband multimedia communication are being deployed around the world. Standards include HIPERLAN/2, and IEEE 802.11a /802.11g. These systems provide channel adaptive data rates up to 54 Mbps over short ranges. It is likely that WLANs will become an important complementary technology to 3G cellular systems and typically used to provide 'hot-spot' coverage. In this paper, work performed under the framework of the IST ROMANTIK project for the use of WLANs in conjunction with UMTS is presented. In order to quantify the throughput enhancement benefits offered to a cellular network by wireless LAN technology, novel ray-tracing, software-simulated physical layer performance results and optimal base-station deployment analysis have been applied to inter-networking.


This document provides a framework to address the GMPLS routing and
signalling issues to support Generalized Multi-Protocol Label
Switching (GMPLS)control of Optical Transport Networks (OTNs) as
specified in ITU-T Recommendation G.709 as published in 2016.


Based on the data during 1997-2008 of 29 provinces in China,this paper studies the influencing factor of Urban Growth in China by using SAR and SEM model of panel spatial econometrics.The results show that(1) the GDP and FDI and fixed investment are key factor of Urban Growth,the rate that the model explain urban growth can amount to 70%.(2) there is spatial spillover in Urban Growth of China.This shows that there is a strong bandwagon effect among the local governments in urban growth.


217 Dear Editor, Dental health care professionals are facing challenges in managing acute or chronic dental conditions due to failure in regression of symptoms or side effects of traditional treatment regimens. Complementary therapies are now becoming the rule rather than the exception in the management of headache and facial pain. It is incumbent on physicians to be aware of and to have a working knowledge of these increasingly popular modalities. A number of unconventional medical methods are being used in dentistry. These include regulation thermography, homeopathy, nosode therapy, acupuncture, magnetic field therapy, ozone therapy, Mora therapy, and lymph drainage.[1] Complementary medicines are defined as herbal medicines, homeopathic remedies, and essential oils. Herbal medicine is completely different from homeopathy, about 65% of whose products from plants, with the others coming from animals (e.g., honeybee) or minerals, such as sulfur. The basic principle of homeopathy is selection of a remedy, which if given to a healthy individual will produce a range of symptoms similar to those observed in the ill patient ("like cures like"). Only minute amounts are given to avoid toxicity. Only one remedy is used at any one time. Dilute tinctures are used rather than concentrated ones. In homeopathic practice, it is common to use medication in tablet form. The standard tinctures used in Western tradition herbal medicine are very different than those used in homeopathy. Alcohol is used to dissolve the plant, and the final product is not diluted. Thus, these remedies are concentrated, highly potent preparations and are usually taken as the unmodified liquid tincture.[2] Homeopathy is the second largest system of medicine in the today's world recognized by the World Health Organization.[3] It is an emerging field of dental medicine that is useful in management of conditions affecting orofacial structures. Belladonna is useful for toothache, early dental abscess, and bruxism as well as in cases of postextraction, for example, dry socket. Natrum muriaticum drug is used in cases which occur due to cold sores and fever blisters, lips and corners of mouth dry and cracked lips. Antimonium crudum, Aconitum napellus, Aranea diadema, Calcarea carbonica, and Chamomilla are useful for a toothache. Arsenicum album is useful for unhealthy, bleeding gums, for diseases involving pulp and periapical region. Aconite can be used for panic, fright, and general mental and physical restlessness or sudden violent attacks, trigeminal neuralgia. Calcarea phosphorica is useful when mouth cannot be opened without pain. Phosphorous is the drug of choice for conditions related to salivation as well as to control the postsurgical bleeding. For aphthous ulcers, candidiasis, and oral lichen planus, borax can be given. Calcarea carbonica is used for a delayed eruption. Kreosotum is used for the decay of milk teeth.[4,5] Homeopathy is a safe and natural alternative that is effective in both adults and children. Homeopathic remedies are used in dentistry to improve the psychological or emotional condition of patients without the side effects of conventional drugs. The knowledge and understanding of homeopathic approach of treatment in dental diseases are still an ongoing process, and further research should be carried out in this regard.


The authors examine legal and ethical challenges for the psychiatrist when a defendant who is incompetent to stand trial declines to take prescribed psychotropic medication.


Funding information Jiangsu 333 Project, Grant/Award Number: BRA2016353; Natural Science Foundation of China, Grant/Award Numbers: 21525311, 21773027; National Key Research and Development Program of China, Grant/Award Number: 2017YFA0204800; Scientific Research Foundation of Graduate School of Southeast University, Grant/Award Number: YBPY1969 Abstract The existence of intrinsic ferromagnetic semiconductors (FMSs) in twodimensional (2D) materials has been a long-term concern and pursuit. Recent breakthroughs in the 2D FMSs, such as CrGeTe3 and CrX3 (X = Cl, Br, I) from bulk down to monolayer, have stimulated intensive researches on new physical phenomena and creative concepts. This minireview mainly summarizes recent progress of 2D intrinsic FMSs in theoretical side, and focuses on the ongoing strategies proposed to enhance ferromagnetism, involving the mechanisms of magnetic exchange interaction and the significance of magnetic anisotropy. Meanwhile, spin-related multifunctionality with ultrathin FMSs and their van de Waals heterostructures in magnetoelectric, valleytronic, and nondissipative electronic technology are introduced, as well as the current challenges and the prospects in this field are discussed.


Text is the largest communicative unit in translation,and the success of translation depends on the achievement of the commu- nicative function of text,Composition translation takes text for the object of translation and the basic unit,and it lays stress on text analysis and pragmatics meaning.


Background : This research aims to analyze the information of genu axial section image quality using T2 STIR and SPAIR sequences at Mayapada Hospital.
Methods : The design of this research is quantitative analytics with experimental approaches conducted at the Mayapada Hospital Radiology Installation with the study population taken from all MRI genu examination patients during September-December 2020 with a study sample of 5 patients aged 18-40 years with various complaints on Genu. Then, reconstruction is carried out with a stunt cut techniques on STIR and SPAIR sequence.
Result : The result of this study showed a difference in T2 STIR d an T2 SPAIR with p value of 0.025 < 0.05.
Conclusion : The contrast of MRI genu sequence STIR is brighter than SPAIR sequence as evidenced by the calculation of CNR value of STIR sequence 8,388 higher than SPAIR sequence value of 5,345. So it can be concluded that in MRI genu examination, the CNR value on the STIR sequence of a stunt pieces with SPAIR sequence of a stunt pieces has a significant difference.


This chapter explores how we might deal with the prevalence of disequilibria and radical uncertainty in complex economic systems, and examines the potential of agent-based models as a tool for helping us understand the dynamics of these systems and the impact of policy interventions.


In the course of a revision of the Malesian genera included by Radlkofer (Pfl. Reich Heft 98, 1932) in the Sapindaceae-Aphanieae and Lepisantheae, attention had to be paid to the genus Phoenicimon Ridl. Ridley described it in the Sapindaceae and expressed its supposed relationships more precisely by giving it the number 7A, between 7 Lepisanthes and 8 Otophora, and by adding the note 'Apparently most nearly allied to Otophora .... ' A study of both syntypes of Phoenicimon rubiginosus Ridl., the only species, and of some more specimens revealed its true identity as a species of Glycosmis in the Rutaceae. This identification was confirmed by Dr. C. G. G. J. van Steenis and by Dr. R. C. Bakhuizen van den Brink.


Homogeneity and heterogeneity are one of the critically studied and implementable concepts, become vital constituents in developing advanced electronic devices. In semiconductor history, many materials had tried to use as electronic devices such as capacitors, resistors, diodes, transistors, FET-MOSFET etc. Diode is the pioneer of the semiconductor industry, which established the basics of integrated circuits and catches attention towards semiconductor applications such as radio detectors. Eventually over the due period, diode has gained remarkable applications and still widening its horizon in major domains like rectifiers, sensors, modern displays etc. Semiconductors working as electric or electronic devices is very much dependent on the material's electric, electromechanical, thermal behavior, for a long silicon was main attraction of researchers to understand these behaviors and derived its application. Every material is possessing energy band, which help us to study its electrical characteristics and behaviors. Heterojunction meaning to connect two dissimilar materials together sharing a common interface, which can act as a junction. In modern technologies, heterojunction became a well-known process of improving quality of particular device. In our research, we are focusing on to Silicon Carbide heterojunction based device with different structures. Silicon Carbide polytypes such as 3C, 4H and 6H exhibits better electrical properties and used for Power electronic devices in general. In this paper, we are discussing the investigation of n type Silicon Carbide - Silicon heterojunction diode. For realizing its 2D structure and performing different simulation based study, we have used SILVACO ATLAS TCAD. In this paper, we focused on I-V behavior of Silicon Carbide - Silicon heterojunction diode with different internal structures. All simulations performed over the range of −10V to +10V voltage range. 2D structure built with 10mm by 10mm boundary also have uniform doping concentration throughout the device.


Summary: Metaphit [an analogue of phencyclidine (PCP) with an acylating isothiocyanate group] induced audiogenie clonic to clonic‐tonic seizures in mice exposed to audio stimulation 24 h after metaphit administration. The incidence of seizures was reduced by treatment 30 min before audio stimulation with specific PCP‐like compounds [5‐methyl‐10, ll‐dihydro‐5H‐dibenzo(a, d)cyclohepten‐5,10‐imine maleate (MK‐801), and PCP itself], competitive N‐methyl‐d‐aspartate antagonists 2‐amino‐5‐ phosphonopentanoic acid (AP‐5 and NPC‐12626), antiepileptic drugs [phenobarbital (PB), phenytoin (PHT)], and γ‐aminobutyric acid (GABA) agonists (muscimol and diazepam). In contrast, when given in conjunction with metaphit, most of these drugs were ineffective in protecting animals from audiogenic seizures 24 h later. Only compounds with long half‐lives (t½) such as MK‐801, PB, and PHT had a protective effect. High‐performance liquid chromatography (HPLC) determination of [3H]MK‐801 showed its long‐term presence in the brain after intraperitoneal (i.p.) administration of [3H]MK‐801. Audiogenic seizures observed 24 h after metaphit administration were potentiated by administration of the GABA antagonist picrotoxin 15 min before audio stimulation, and picrotoxin‐induced spontaneous seizures were enhanced by pretreatment (24 h earlier) with a dose of metaphit that in itself did not produce spontaneous seizures at the time of the picrotoxin test. Similar observations were made with N‐methyl d‐aspartic acid (NMDA) instead of picrotoxin. Thus, an interplay exists between excitatory glutaminergic and inhibitory GABAergic circuitries in the metaphit seizure model.


B7 homolog 3 (B7‐H3) is an immunomodulatory molecule that is highly expressed in prostate cancer (PCa) and belongs to the B7 superfamily, which includes PD‐L1. Immunotherapies (antibodies, antibody‐drug conjugates, and chimeric antigen receptor T cells) targeting B7‐H3 are currently in clinical trials; therefore, elucidating the molecular and immune microenvironment correlates of B7‐H3 expression may help to guide trial design and interpretation. The authors tested the interconnected hypotheses that B7‐H3 expression is associated with genetic racial ancestry, immune cell composition, and androgen receptor signaling in PCa.


A molecule traveling in a realistic propagation environment can experience stochastic interactions with other molecules and the environment boundary. The statistical behavior of some isolated phenomena, such as dilute unbounded molecular diffusion, are well understood. However, the coupling of multiple interactions can impede closed-form analysis, such that simulations are required to determine the statistics. This paper compares the statistics of molecular reaction-diffusion simulation models from the perspective of molecular communication systems. Microscopic methods track the location and state of every molecule, whereas mesoscopic methods partition the environment into virtual containers that hold molecules. The properties of each model are described and compared with a hybrid of both models. Simulation results also assess the accuracy of Poisson and Gaussian approximations of the underlying Binomial statistics.


Background: Current-generation drug-eluting stents unblock atherosclerotic arteries, inhibit restenosis, but also render the artery prone to thrombosis by inhibiting endothelial cell function. Hence, there is strong clinical interest in developing stents that inhibit restenosis, yet are less thrombogenic. Goals of this study were to 1) develop an ex vivo method to measure platelet adhesion and aggregation on coronary stents under clinically-relevant conditions, and 2) test the hypothesis that treating metal stents with trimethylsilane (TMS) through a novel glow discharge process that coats stents with a nanoscale layer of hydrophobic plasma coating, with or without additional post-deposition glow discharge treatment with NH3 and O2 gas, generating elemental nitrogen and oxygen on the stent surface, inhibits platelet adhesion to stents.

Methods: Bare-metal stents (BMS) made of 316L stainless steel was deployed in Masterflex tubing by inflating an over-the-wire coronary balloon within the stent. Tubing containing stents was filled with porcine indium-labeled platelets in anticoagulated whole blood and the ends were connected to create a closed circuit, which was connected to a peristaltic pump to generate unidirectional flow with shear stress of 67 s-1, similar to that present in human coronary arteries. After 30 min of continuous flow at 37°C the tubing was disconnected and extensively rinsed to remove blood. Platelet adhesion to stents was measured with a gamma counter and by scanning electron microscopy (SEM).

Results: Platelet adhesion to metal stents treated with TMS followed by NH3 and O2 (DC-TMS+NH3/O2) was 56±8.2% reduced compared to BMS (n=12; P=0.003), whereas TMS treatment alone did not significantly inhibit platelet adhesion. SEM confirmed significantly decreased platelet deposition on DC-TMS+ NH3/O2 stents vs. BMS.

Conclusions: A novel glow discharge surface modification involving TMS, NH3, and O2 gas generates stents with a bioactive surface that resists platelet adhesion under physiological conditions. Our ex vivo perfusion circuit facilitates rapid and precise comparison of stent thrombogenicity under physiological conditions, which should prove useful to other investigators developing coronary stents for clinical use.


Digital marketing (or online marketing) are all the actions and strategies that use the internet, digital devices and online platforms to promote, sell or communicate everything related to products or services, customer service and performance monitoring. . This research focuses on analyzing the importance of it in companies as a vital tool, detailing fundamental strategies to achieve proposed goals.The methodology used in the research is Quantitative, data collection was carried out through a survey with semi-open questions.The results indicate that Digital Marketing is extremely important for companies, as well as being a useful tool for them, but the familiarity of the respondents with this system is quite regular.Effective strategies such as television and radio advertising were identified to increase the customer base and improve the profitability of a company. Likewise, effective traditional marketing strategies such as social networks and influence marketing are mentioned, since social networks play a fundamental role in the digital marketing strategy within companies.As a result of the research, useful tips are proposed to implement within companies and promote digital marketing in companies. These include the use of social media and transparent client communication


DNA microarray has been applied to DNA sequencing,pharmaceuticals analysis,gene expression and so on. One of the key technologies is immobilizing DNA effeciently on modified surface. The main of support surfaces and the immobilization of DNA or Oligonucleotide are introduced in this article.


The invention discloses beef noodle in a stone pot. The beef noodle is composed of fine dried noodles, a sauce bag and a seasoning powder bag, wherein the sauce bag is prepared from palm oil, beef fat, beef, onion, ginger, garlic, star aniseed powder, cinnamon powder, medium chili flake, salt, monosodium glutamate, extract beef cream, soy sauce, glucose, cooking wine, paprika red pigment and beef flavor; the seasoning powder bag is prepared from salt, monosodium glutamate, sugar, I+G, yeast powder, hydrolyzed vegetable protein, garlic powder, ginger powder, black pepper powder, guar gum, creamer, soybean protein powder, caramel pigment, beef powder, powdered milk, star aniseed powder, cinnamon powder, curcuma powder, highly-hot chili powder, cheese powder, ethyl maltol, disodium succinate, medlar and a flavour enhancer. The beef noodle in the stone pot has the advantages of special taste, rich nutrition, convenience in eating, and reasonable and scientific formula, has the efficacies of enhancing the immunity and balancing the absorption of nutrients, is a good nutrition food and has a wide market prospect.


Although many studies have been conducted to extract buildings from airborne lidar data, most of them assume that all the boundaries of a building are straight line segments. This makes it difficult to model building boundaries containing curved segments correctly. This paper aims to model buildings containing curved segments as combination of straight lines and arcs. First, two sets of boundary points are extracted by adaptive convex hull algorithm and local convex hull algorithm with a larger radius. Then, arc segments are determined by average spacing of boundary points and intersection ratio of perpendicular lines. Finally, building boundary is modeled through regularization of least squares line or circle fitting. The experimental results showed that the proposed method can model the curved building boundaries as arc segments correctly by completeness of 69% and correctness of 100%. The approach will be utilized effectively to create automatically digital map that meets the conditions of the Korean digital mapping.


: Randomly collected decaying leaves and senescent, dried leaf litter of Eucalyptus rostrata , Ficus nitida , Phoenix dactylifera, and Phragmites australis submerged for one year in the River Nile, small and large irrigation canals at Sohag, Egypt, were investigated for freshwater fungi. Thirty-six fungal species belonging to 33 genera were identified from 982 fungal collections recorded from 864 samples. The most common genera were Halobyssothecium represented by 221 records, Aspergillus (190), and Cylindrocladiella (102). Of the 36 taxa recorded, five are new to science, of which Robillarda sohagensis was previously described. Multivariate clustering analysis based on similarity between the 96 fungal communities has produced 13 groups. The type of collected samples; random or baited and the host are the important factors that influenced the fungal communities. Halobyssothecium unicellulare was collected from 59 communities followed by Aspergillus flavus (48) and Cylindrocladiella pseudohawaiiensis (32). The highest numbers of species and records were reported from randomly collected leaves of Phoenix dactylifera and Phragmites australis from both the River Nile and the small irrigation canal. Bartalinia robillardoides was reported for the first time from freshwater habitats in Egypt during the present study. A description and illustration of the Egyptian collection are provided. Phylogenetic analyses of the LSU rDNA sequence confirmed its identity.


A comparison of the potentials of ep and e + e − machines to probe the structure of the photon is performed. In particular, the kinematic reach of a proposed future ep facility, THERA, is compared with those of current colliders, LEP and HERA, and with the proposed linear collider, TESLA. THERA like HERA will use a proton beam of 920 GeV but with an increased electron beam energy of 250 GeV allowing higher scales, ˆ Q 2 , and lower values of parton momentum fraction in the photon, x, to be probed.


The influence of cracking selenium on the structure and device parameters of Cu( In1- xGax)-Se2( CIGS) thin films was investigated. The activity of cracked selenium can be controlled by moderating the temperature of thermal cracking system employed in our self-designed selenization furnace. The HC-Se atmosphere can enhance the Ga concentration on the film surface and increase the band-gap energy of the CIGS film surface. In addition,HC-Se atmosphere can alleviate the "phase separation". Consequently,Vocvalue of the solar cell increases about 34. 6%. The device conversion efficiency using the novel thermal-cracking system increases by about 45. 5% from 6. 02% to8. 76%.


Epitaxial graphene on SiC(0001) suffers from strong intrinsic n-type doping. We demonstrate that the excess negative charge can be fully compensated by non-covalently functionalizing graphene with the strong electron acceptor tetrafluorotetracyanoquinodimethane (F4-TCNQ). Charge neutrality can be reached in monolayer graphene as shown in electron dispersion spectra from angular resolved photoemission spectroscopy (ARPES). In bilayer graphene the band gap that originates from the SiC/graphene interface dipole increases with increasing F4-TCNQ deposition and, as a consequence of the molecular doping, the Fermi level is shifted into the band gap. The reduction of the charge carrier density upon molecular deposition is quantified using electronic Fermi surfaces and Raman spectroscopy. The structural and electronic characteristics of the graphene/F4-TCNQ charge transfer complex are investigated by X-ray photoelectron spectroscopy (XPS) and ultraviolet photoelectron spectroscopy (UPS). The doping effect on graphene is preserved in air and is temperature resistant up to 200 C. Furthermore, graphene non-covalent functionalization with F4-TCNQ can be implemented not only via evaporation in ultra-high vacuum but also by wet chemistry.


The utility model discloses a self-balanced vehicle auxiliary wheel structure. A self-balanced vehicle comprises a telescopic device, a linkage part, a driving shaft, a driven shaft, a pair of driving elements and a pair of auxiliary wheels. The telescopic device is pivoted on a vehicle frame of the self-balanced vehicle, and the telescopic device is provided with an output shaft. One end of the linkage part is pivoted on the output shaft, and the other end of the linkage part is fixed on the driving shaft. The driving shaft and the driven shaft are fixed with the driving elements respectively. The driving elements are provided with gear teeth which are mutually meshed. The auxiliary wheels are connected with the driving elements. The self-balanced vehicle auxiliary wheel structure can maintain the stability of the self-balanced vehicle and ensure the safety of a driver when the self-balanced vehicle loses the self-balancing function or the speed is high. The utility model further discloses a self-balanced vehicle with the self-balanced vehicle auxiliary wheel structure.


Due to the impact of high performance customer service, many organizations attempt to improve customer support services using helpdesk systems. The objective of this study is to develop a Central Trouble Ticketing (CTT) system for effective information dissemination, efficient management of operations and to resolve challenges of Center of Training and Learning (CTL) through using e-learning website at a University. As for implementation phase, the Hypertext Preprocessor (PHP) was used as the server side programming tool and MySQL database as backend. The benefits of the Central Trouble Ticketing system include creation of a medium for lecturers to pass their complaints or messages to the technical department for speedy attention; and provision of better and faster operational processes which will reduce time spent on documentation. The system is more reliable, effective and convenient than the manual method in reporting cases of complain within the university technical community.


In this paper we present a design procedure of high frequency amplifiers that uses the gain peaking technique to extend their bandwidth. Namely, the performance of single inverters with and without gain peaking elements, was compared theoretically. Then, we derived simple analytical formulae that we have used together with powerful computer aided design tools to estimate the peaking inductances added to GaAs wideband monolithic direct coupled amplifiers to extend their frequency bands. It is shown that the gain peaking technique is effective for extending the bandwidth, for two circuit blocks in cascade a gain between 12 and 16 dB from dc up to 12-GHz was predicted by the simulation results.


The object of the statistical analysis is the statistical information. To correctly identify the type of statistical information is the most important prerequisite for rational use of statistical analysis methods. In this paper, the common methods for normality test are introduced theoretically. And the figure test and partial kurtosis test of normal distribution are proposed with detailed testing steps, suitable situation and mathematical model. It is demonstrated by simulation that both have good test results and practical value.


Fatigue is a common symptom frequently reported in many disorders but little is known about the prevalence of fatigue in asthma. The objective of this study was to determine the prevalence of fatigue in asthmatic patients, the effect of fatigue on asthma quality of life and the relationship between fatigue and anxiety/depression


BATTERY IS MADE BY A NUMBER OF ELEMENTS ARRANGED IN ELECTRICAL CONTACT WITH EACH OTHER, EACH ELEMENT WITH TWO ELECTRODES POREUSES31, 41, ELECTROLYTE FILLING THE GAP IS BETWEEN THOSE TWO PADS AND BIPOLAR CURRENT COLLECTORS IMPERMEABLES. ONE OF ELECTRODES31 IS SUBJECT TO CADRE32 WITH A HOLE CENTRAL34. A FACE50 THAT INCLUDES THE CADRE32 RAINURES51 FOR ONE HAND THE MOVEMENT OF ELECTROLYTE OF PORT ENTREE38A TO A ROOM DISTRIBUTION CONTACTING ELECTROLYTE FUND AND OTHER HAND THE EVACUATION OF ELECTROLYTE TO A SORTIE38B HOLE. ELECTROLYTIC COMPARTMENT IS CLOSED BY ANOTHER ISOLANT42 FRAMEWORK ON WHICH SHALL THE SECOND ELECTRODE41. INVENTION MADE ON THE SEALING OF ELECTROLYTE DISTRIBUTION NETWORKS AND FUEL THROUGH THE IMPLEMENTATION A MULTIPLE GROOVES EXCEEDING THE SURFACE OF FRAMES.


Recently, seismic processing techniques accommodate seismic anisotropy in the wave propagation phenomena for better imaging of subsurface structure and for more precise estimation of subsurface material parameters. After 30 years of research on seismic anisotropy, it has become well known that subsurface materials are more anisotropic than the foreseen. For example, shale rocks are anisotropic in the order around 30%, for which it is necessary to take the anisotropy into account for planning hydraulic fracturing. It is, however, difficult to estimate directly all of 21 independent parameters in the general elastic medium in the 3D Cartesian coordinate system, and a method to deal with seismic anisotropy for complex anisotropic materials has been waited for. In this research, we set model parameters as orientation and dip as well as 5 independent parameters instead of estimating 21 parameters directly under a hypothesis that the stable solution could be obtained. We attempt to estimate these parameters by full waveform strategy because azimuthal anisotropy influences the waveform. Low computational costs by efficient parameterization technique make it possible to work on 3D sonic logging model. Since one of the crucial problems of FWI is the predicted model would be possible to converge to local minimum as the number of parameters increases, the small number of unknowns in the proposed strategy could play a key role to deal with complex anisotropy. As a result, all elements come close to true values by full waveform inversion process. Our results suggest that the proposed parameterization strategy and FWI have an advantage over the conventional methods in terms of accuracy and stability.


One of the most promising applications for high temperature superconductors (HTSCs) is for use as signal interconnects between bare integrated circuits (ICs) in multichip modules (MCMs). For HTSC MCM and other related electronic applications, it is necessary to fabricate several YBa/sub 2/Cu/sub 3/O/sub 7-x/ (YBCO) layers separated by thick low dielectric layers. In this work, YBCO/yttrium stabilized zirconia (YSZ)/SiO/sub 2//YSZ/YBCO multilayer structures have been successfully deposited with patterned YBCO layers on single-crystal YSZ substrates. A reactive sputtering technique was used to grow the SiO/sub 2/ layer and the ion beam assisted deposition (IBAD) method was used to form biaxially aligned YSZ layers. In contrast to previously reported work, the top YBCO layer did not show any cracking. Using this process, a novel two-layer test vehicle was fabricated. A clock distribution circuit was mounted on the superconducting test vehicle to form a ring oscillator. The functionality of the test vehicle was found to be about 100 MHz.


The implications of nonlinear thermal radiation on a Cu–water nanofluid flow with varying viscosity characteristics and convective boundary conditions are investigated numerically in this article. The nonlinear model takes the combined effects of Joule dissipation and Ohmic heating into consideration. The Spectral Local Linearization Method (SLLM) is used to address the nonlinear governing model. The numerical investigation's findings were conducted and compared with the existing study. In Cu–water nanofluid flows with variable viscosity and convective boundary conditions, nonlinear thermal radiation plays an important role, as this work insightfully demonstrates. Pertinent results for velocity, temperature, skin friction, and heat transfer rate are displayed graphically and discussed quantitatively with respect to various parameters embedded in the model. The results revealed that the Cu–water thermal distribution lessens as the nanoparticle volume fraction upsurges. The outcomes of this study have potential applications in industrial systems such as power plants, cooling systems, and climate control systems.


Basing on Stokes'law and Newton's second law,the function of moving distance of spherule with velocity is deduced before the velocity of spherule comes to the terminal velocity.Using this result,the starting time is determined,and the rational size of spherule is discussed.


Container technology is a light weight back-end virtualization solution which copes with the growing demand for internet service concurrency. For security and availability, network isolation is essential in container network. Label based network access control policies are employed as a network isolation solution by the famous container orchestrator, Kubernetes. The large scale and flexibility of container networks implies a prohibitive complexity, whereas the constant changes of policies and containers demand a short response time, thus the policy verification needs to be efficient. However, there is no existing tool that solves the verification problem of label based network access control policies. Kano is proposed as the first system to cover container network policy verification, including incremental verification. It leverages on a prefiltration algorithm to reduce the time complexity of reachability matrix calculation from O(n2) to O(n). With predefined and user-defined constraints which can be verified quickly with the reachability matrix, Kano removes potential risk from the container network. Based on the verification result, Kano provides advices to reinforce the security and availability of the container network.


Treatment of patients with hemophilia A is based on the administration of exogenous Factor VIII (antihemophilic globulin). Usually this is accomplished by infusing fresh, fresh-frozen, or reconstituted freeze-dried normal human plasma. The large volume of plasma needed to achieve and maintain hemostasis may be sufficient to cause circulatory overload, and thereby represents a critical limiting factor in therapy. During recent years, several therapeutically effective concentrated Factor VIII preparations have become available. These products are similar to Cohn Fraction I, which is prepared from whole plasma by ethanol extraction. Unfortunately, the difficulties encountered in procuring large volumes of fresh plasma to use as raw material, and other problems related to the lability of Factor VIII, the complexity of necessary equipment and methods, and the need for rigid bacteriologic control, have limited production and raised the cost of these products. Attempts to produce an inexpensive concentrate have recently met with success. Two developments have permitted formulation of a method for preparation of Factor VIII concentrate that may be used in any blood bank. The first important observation was that of Pool and Robinson, who found that Factor VIII precipitates with fibrinogen in the cold, just as it does in salting-out and ethanol precipitation procedures. The second contributing factor was the definition of plasmapheresis as an alternate form of blood donation which permits collection of large


The quality and quantity of advance directives for healthy older people need to increase. Quality will improve with literal interpretations of do‐not‐resuscitate orders and more comprehensive directives. Changing the term "DNR" to "No ACLS (Advanced Cardiac Life Support)" should discourage health‐care providers from subsuming other limitations under the directive to withhold resuscitation. Other aggressive medical and surgical interventions should be prospectively considered in addition to resuscitation. The quantity of advance directives will increase when physicians feel motivated to devote time and expertise to thorough discussions of advance directives. Although education and legislation will motivate physicians to some extent, their roles are limited. Fair reimbursement for this primary‐care service is the most effective motive. The initial investment by Medicare may save large sums in the long run by reducing expensive, undesired care for older people.


OBJECTIVE:To study long-term outcomes in patients treated with IFNB-1b after clinically isolated syndrome (CIS). BACKGROUND:In BENEFIT, patients with CIS were randomized to IFNB-1b or placebo (PL) treatment. After the second clinical event or after 2 years, all patients were treated with IFNB-1b. Mean delay of IFNB-1b in PL was 1.33 years. Comprehensive clinical, MRI, and PROs at 11 years post-randomization are reported. DESIGN/METHODS:All originally randomized patients were asked to undergo clinical, MRI, laboratory, and PRO assessments 11 years after randomization. RESULTS:281 patients were identified (60[percnt] of originally randomized, 72.6[percnt] of eligible patients at participating sites); 278 enrolled. Baseline characteristics were similar to the original BENEFIT population. At Year 11, patients randomized to IFNB-1b still had lower overall annualized relapse rate (p=0.0018) and longer time to first relapse (p=0.0005) and clinically definite MS (p=0.0012). Median EDSS score was 2.0 (change from baseline 0.5) in both groups. PASAT scores remained high (overall median 56 [IQR 10]). Of the 81.3[percnt] working at CIS start, 73.4[percnt] were still employed (64.4[percnt] fulltime). 12.2[percnt] retired early or were on long-term disability (2.9[percnt] at baseline). 64.0[percnt] did not report any sick leave during the past 12 months. Health-related quality of life remained stable (median [IQR] change from baseline EQ-5D: 0.000 [0.209], FAMS TOI: -7.54 [27.17]. Median (IQR) fatigue (FSMC) score: 45.00 (40.00), 46[percnt] of patients without fatigue (cut-off score\textless43), median (IQR) depression (CES-D) score: 9.00 (15.00). MRI findings were similar across groups: 86.4[percnt] had no gadolinium-enhancing lesions; median (IQR) number of new T2 lesions since 5-year MRI: 2.0 (6.0), T2 volume: 1760.0mm³ (3963.0mm³), cortical lesions: 2.0 (5.0), brain volume 1519.0cm³ (152.0mm³), mean cortical thickness 2.64mm³ (0.56mm³). CONCLUSIONS:Results from BENEFIT11 support a long-term impact of early treatment with IFNB-1b on clinical measures, including cognition and fatigue, and health economic and MRI outcomes. Study Supported by:Bayer HealthCare Pharmaceuticals Disclosure: Dr. Edan has received personal compensation for activities with LFB, Biogenidec, speaking from Serono, Inc., Sanofi, Teva, and Bayer Pharmaceuticals Corporation as a consultant and/or scientific advisory board member. Dr. Freedman has received personal compensation for activities with Bayer Healthcare, Biogen Idec, Chugai, EMD Canada, Genzyme, Novartis, Sanofi-Aventis, and Teva Canada Innovation. Dr. Montalban has received personal compensation for activities with Bayer, Biogen Idec, EMD, Genentech, Genzyme, Merck Serono, Neurotec, Novartis, Sanofi-Aventis, Teva Pharmaceuticals, and Almirall. Dr. Miller has received personal compensation for activities with UCL Institute of Neurology, Biogen Idec, GlaxoSmithKline Inc., Novartis, Merck & Co. Inc., Chugai, and Mitsubishi Pharma. Dr. Miller has received personal compensation in an editorial capac Dr. Hartung has holds stock and/or stock options from Opexa Therapeutics. Dr. Hemmer has received personal compensation for activities with Roche, Novartis, Bayer Schering, Merck Serono, Biogen Idec, GlaxoSmithKline, Chugai Pharmaceutical, Micromet, and Genzyme as a scientific advisory board member. Dr. Fox has received personal compensation for activities Acorda Therapeutics, Bayer Pharmaceuticals Corporation, Biogen Idec, Eli Lilly & Company, EMD Serono, Genzyme Corporation, GlaxoSmithKline, and Novartis. Dr. Barkhof has received personal compensation for activities with Bayer Schering Pharma, Sanofi, Genzyme, Biogen Idec, Teva, Merck Serono, Novartis, Roche, Synthon BV, and Janssen Research as a consultant. Dr. Schippling has received personal compensation for activities with Novartis. Dr. Schippling has received research support from Bayer Schering and Biogen Idec. Dr. Schulze has received personal compensation for activities with PAREXEL International as an employee. Dr. Pleimes has received personal compensation for activities with Myelo Therapeutics GmbH as an employee, and with Bayer Pharmaceuticals Corp. as an employee and consultant. Dr. Pohl has received personal compensation for activities with Bayer Pharmaceuticals Corporation as an employee. Dr. Pohl owns stock and/or stock options in Bayer Pharmaceuticals Corporation. Dr. Sandbrink has received personal compensation for activities with Bayer Pharmaceuticals Corporation as an employee. Dr. Sandbrink holds stock and/or stock options in Bayer Pharmaceuticals Corporation. Dr. Suarez has received personal compensation for activities with Bayer Pharmaceuticals Corporation as an employee. Dr. Wicklein has received personal compensation for activities with Bayer Pharmaceuticals Corporation as an employee. Dr. Kappos has received personal compensation for activities with Actelion Pharmaceuticals


Social media data provides researchers with insight into how social media platforms are used, and how they shape the lives of their respective users. While exploring and analyzing data has vast research potential, the process for doing so is tedious, time-consuming, and difficult, especially for non-technical researchers. In most cases, researchers require funds and technical personnel to even begin exploring data-related ideas. For those that do have the resources, low quality and high latency data is typically the end result. To decrease the overall gap between the data and the researcher, we propose a method and prototypical web-based system that utilizes Twitter's latest API offering to enable researchers to collect high quality data themselves at minimal cost. The system has been evaluated through multiple implementations at multiple universities. Our initial findings are positive, indicating that our design and prototype alleviate the major issues faced by non-technical researchers collecting social media data.


Preprocessing is a critical step in next generation sequencing (NGS) data analysis, since any error or artifact in library preparation and the sequencing process can affect subsequent steps, leading to possibly erroneous biological conclusions. In this work, we propose ZSeq 2.0, a fully automatic NGS preprocessing method, which combines the strength of the original ZSeq method with a free of parameters scheme that automatically detects and filters out low complexity and highly biased regions, without any need for parameter adjustment. We estimate parameters by applying dynamic penalty rates to high and low GC-content sequences. We also use a labeling rule method to detect outlier sequences that have very low NUS. Some other preprocessing features have been added to ZSeq2.0, including adapter detection and low-quality nucleotides trimming at each side of the sequence. ZSeq2.0 is publicly available and can be downloaded from http://sourceforge.net/p/ZSeq/wiki/Home/.


EcoRI restriction endonuclease fragments from the mouse 1,350-base-pair EcoRI satellite sequence were cloned in pBR322 plasmid. One of these fragments, SAT-1, was hybridized to various restriction fragments from cloned mouse intracisternal type A particle (IAP) genes and to mouse total genomic DNA. Hybridization occurred between the SAT-1 sequence and each of the IAP clones. The common region of hybridization in each of the clones was the long terminal repeat region of the IAP genes.


Position information is crucial for diverse applications in wireless sensor networks (WSNs). In this letter, we study performance limits of anchorless cooperative localization in WSNs with strong sensor position uncertainty. Based on an approximated Cramér–Rao bound decomposition, we are able to show that the average localization performance of a network is largely determined by the number of agents and the signal metric employed rather than the network topology. Some properties of the proposed approximation, including its behavior in extended and dense networks and the performance bound of individual agents, are further analyzed. Finally, numerical results are used to verify our analysis.


In this paper, a group of test results were analyzed by employing principal components analysis. The factors related to the performance results of the mathematic majors, were determined. The factors are classified into: "synthesis", "fundament", "network and model", "fundament of communication", "abstractly thinking ability", and "programming ability". The factors not only embody the speciality, but also get a further analysis of the rationality of the course structure and the teaching process. The information offered is very valuable to improve our college's teaching-managing level and the construction of the new major.


Background To date services for children with Developmental Coordination Disorder (DCD) have not been informed by the perspective of children with DCD. This study aimed to synthesise the findings of discrete qualitative studies reporting the lived experiences views and preferences of children and young with DCD using a meta-ethnographic approach to develop new conceptual understandings. Methods A systematic search of ten databases; Academic Search Complete, AMED, CINAHL, ERIC, MEDLINE, PsychArticles, PsychInfo, EMBASE, SPORTDiscus, and Web of Science, was conducted between March and April 2019, and updated in early June 2020. Meta-ethnography, following the method described by Noblit and Hare was used to synthesise included studies. The Joanna Briggs Institute Checklist was used to appraise all included papers. PROSPERO registration number CRD42019129178. Results Fifteen studies met the inclusion criteria. Meta-ethnographic synthesis produced three themes; a) 'It's harder than it should be': Navigating daily activities b) Fitting in, and c) 'So what? I drop things': Strategies and supports to mitigate challenges. Children with DCD describe a mismatch between their abilities and performance norms for daily activities that led to a cascade of negative consequences including negative self-appraisal, bullying and exclusion. In the face of these difficulties children described creative and successful strategies they enacted and supports they accessed including; assistance from others (parents, friends and teachers), focusing on their strengths and talents, accepting and embracing their difference, adopting a "just do it" attitude, setting personal goals, self-exclusion from some social activities, using humour or sarcasm, viewing performance expectations as a social construct, and enjoying friendships as a forum for fun, acceptance and protection against exclusion. Conclusion Service provision for children and young people with DCD should address the social and attitudinal environments, focus on friendship and social inclusion and address stigma-based bullying particularly within the school environment. Furthermore, practitioners should identify and foster children's own strategies for navigating daily life activities with DCD. The identified themes resonate with contemporary disability theory and the International Classification of Functioning. The social and attitudinal environmental context of children and young people with DCD profoundly influences their experiences. Future intervention development and service provision for children and young people with DCD should consider opportunities to address social and attitudinal environmental factors.


Conclusion Nutrition of the animal is an important factor in the effects noted on the breasts of hypophysectomized rats after injection of estrogenic hormone. It is probable, however, that this hormone exerts a part of its effect on the breast by way of the hypophysis.


ARIMA model and two-stage OLS method are employed to test impact of expected money supply and non-expected money supply on GDP from 1994 in China.The empirical results show both expected money aggregate and unexpected money aggregate have significant effects on output in the short run and non-expected money aggregate have more significant impact on output.In the long run,the positive and negative effects of expected monetary and non-expected money on output are offset.Monetary policy in China shows neutral in the long-term.


Methicillin-resistant Staphylococcus epidermidis (MRSE) and methicillin-resistant Staphylococcus haemolyticus (MRSHa) are important coagulase-negative staphylococci. They are often isolated from bacteremia in humans mainly due to their ability to form biofilm on the surfaces of medical devices. Papain is a complex mixture of proteolytic enzymes and peroxidases extracted from the latex of Carica papaya and it is recognized by accelerating the healing process of wounds. This study aimed to evaluate the ability of the MRSE and MRSHa isolates to produce biofilms. Besides this, the ability of papain to inhibit the formation of biofilms or to disrupt the ones already formed by those bacteria was analyzed. Thirty MRSHa and 30 MRSE were isolated from bacteremia and used in this study. It was observed that papain has ability to reduce biofilms formed by MRSE (p < 0.06) and by MRSHa (p = 0.0005). In addition, papain was able to disrupt mature biofilms made by MRSE (p = 0.014). No antibacterial activity of papain was observed for any isolates of MRSE and MRSHa tested. Papain has been demonstrated as a potential product for reducing biofilm.


PURPOSE: To provide an effective bandage for treatment of clavicle which is comprised of dorsum bandages which extends to cross the dorsum and shoulder bandages connecting with the dorsum bandages and extending beyond the clavicles from axilla, and which is a one piece bandage for clavicle which extends to the connecting distal of which shoulder bandages cross at the center area of the dorsum bandage and extend around the outside of waist to venter. CONSTITUTION: A bandage is formed with non-elastic beltlike material wherein both of shoulder bandages 2, 3 are piled on a dorsum bandage 1 at mutually separating positions of both side dislocated from spine of both of the dorsum bandage 1, bur like bonding is formed on each of the piling position 5, 6, and bur like parts 7, 8 of the bur like bondings and covering parts are respectively provided on the dorsum bandage and shoulder bandages to cover the opposing bur like parts completely by the covering parts. COPYRIGHT: (C)1994,JPO


Adoption of the Information Society in Europe (as well as in the developed world at large), is considered a given and a political priority. The only uncertainty associated with this overwhelming and said to be irreversible trend is the rate of adoption and the nature of the obstacles holding it up. This contribution will argue that the attention and energy vested into studying these issues foster on restrictive perspectives partly based on erroneous assumptions. In particular, it will be argued that most IS adoption indicators are not only diverse (hence hazardous to compare) but more importantly deprived of unequivocal conceptual basis. The central and apparently simple 'Internet use' indicators will be used to elaborate on this issue.


The nineteenth century has long been seen as a century where European powers were acquiring antiquities for display in their national museums. At the forefront of this trend was the British Museum which worked in conjunction with the Foreign Office and Admiralty to bring them back to Britain. Yet current historiography of the region has ignored the role played by another leading government department, the Ordnance Office. The establishment of a permanent British military presence on Malta and in the Ionian Islands had a transformative effect on the study and acquisition of ancient, classical and medieval antiquities from the region as personnel from the civil and military establishments were now able to engage with them at first hand.


Just as norm-complying states adapt their practices to expected behaviors, post-conflict states are forced to adapt their practices and rhetoric to better resist pressures to comply with particular norms. Building on this insight, this paper analyzes three mechanisms through which the ruling elite in present day Serbia strategically constructed commemorative arenas for the purpose of dealing with the opposing demands and norms made both on the international as well as the national level: 1) de-contextualization of memory contents, 2) creation of social narratives of suffering and 3) promotion of the Holocaust memory as a screen memory. These are strategies of silencing which prevent public debate, representation, negotiation and are intended to reduce the tension between the contradicting demands at the international and the domestic levels. I suggest that the gap between the local and global forces and the changing role of the state, makes it possible for memory content to become a currency, a means of achieving certain real or symbolic benefits.


For scaring birds, at least two acoustic signals are generated whose frequencies are periodically modulated within a range between about 30 and 9000 Hz, the modulation period ranging between about 0.01 and about 5 seconds. The signals differ in the frequency modulation range, in the modulation period and/or in duration. The signals are emitted either in fixed or in arbitrary sequence.