Algorithm weight matrixes to accurately express the complex non-linear relationships of creep-rupture strength with testing temperature, time and alloy compositions were obtained by using the back-propagation neural network modeling based on the actual alloy compositions and creep-rupture strength at different temperatures and times for wrought Ni-base superalloys. The results show that the predicted creep-rupture strength data are in good agreement with ones for the given experimental conditions. The accuracy and applicability for the present neural network modeling are thus verified.


With the deepening of enterprises' reform, the duty of safeguarding rights by trade unions is more important.How to bring an important role of safeguarding rights of trade unions is a big problem that trade unions study and deal with.


The purpose of this study is to consider problems and ways of resistance of teachers in the context of their own experiences, emotions, definitions, conceptualizations through their own narratives and interpret in a sociological framework. The particular and unique narratives of teachers are primary and crucial sources in terms of interpreting and understanding the teaching profession in a sociological perspective. This study that is supported by interpretative, feminist and critical pedagogies conceptually and theoretically, focus on teacher as an actor and aims at the voice of teacher. The research was designed according to the qualitative research model. The nine social studies teachers were interviewed and their narratives were analyzed under various categories. The narratives of teachers reveal that teaching profession is learned by informal ways after going into the profession. According to the teachers in the research group, their vocational education is insufficient. Although there are some problems, teachers seem to built up some particular micro strategies of resistance.


Part 7 of a 7-part series: Unaware of the surrounding anger and irritability he&s caused, the passive-aggressive employee is content at doing less when asked for more.


In recent years, our knowledge of neurofibromatosis (NF) has expanded significantly. The location of the NF gene on chromosome 17, for NF 1, and chromosome 22, for NF 2, has been identified, and the clinical variations of the disorder have been more fully delineated. The book was sponsored by the National Neurofibromatosis Founddation, New York, NY, and the approach is varied, with some information written for the layperson and other topics more detailed and professionally oriented. The book is multiauthored and brings together the existing information about NF as of early 1990. It is divided into four sections: "Medical," "Genetic," and "Psychosocial Aspects," and "Appendices." There are 20 chapters covering most of the major areas of concern. Following the introduction and history, there are chapters on diagnosis, neurological aspects, ocular features, NF and cancer, molecular genetics, psychosocial aspects, and many other areas. The chapter organization makes it easy to find


New data shows our Be the Influence - Tackling Binge Drinking initiative's Facebook page is one of the most popular Australian Government social media pages with over 189,000 likes to date.


Abstract : Rock mass failure can occur through the propagation of cracks emanating from and causing coalescence of pre-existing fractures. The objective of this research was to develop a mechanical model for fracture coalescence which can be used in conjunction with numerical methods to simulate rock mass failure. The study consisted of: (1) Monitoring growth in uniaxially compressed gypsum specimens with pre-existing fractures with various arrangements. Consistent coalescence behavior as a function of preexisting fracture geometry was noted and is documented; (2) Development of an analytical coalescence model based on correlations between computed stress/strain fields and observed fracturing in the experiments. Using this analytical model, satisfactory agreement was achieved between simulated and experimental coalescence behavior as a function of pre-existing fracture geometry.


Abstract Introduction. Man is a unique, unrepeatable whole in space and time and that is why he requires a holistic treatment, taking into account physical, psychological, social and spiritual factors. The balanced factors can ensure human well-being and his quality of life. Integrated treatment is especially important for patients in palliative care, which was the basic starting point of our research. In our research we wanted to establish whether the patients in palliative care are treated holistically from the perspective of the nurses and where are the specific aspects of palliative care (psychological, physical, social and spiritual) more visible - in the hospitals or in the home environment. Material and methods. The questionnaire survey was based on the empirical quantitative methodology; a descriptive causal non-experimental method was used. The number of the included sample was 127 nurses (92 hospital nurses, 35 community nurses). To test the differences between the groups (hospital, community nursing), the single factor analysis of variance was used. All the research participants were ensured anonymity and they had the right to withdraw from the study before or during the questionnaire completion. Results. The physical aspect of the treatment was statistically significantly higher assessed by nurses in a hospital setting (̅χ =3.83; s=1.012; p=0.042). The psychological and spiritual aspects were higher assessed in community nursing setting and social aspect in hospital setting. Conclusions. Our research has highlighted the shortcomings of the holistic approach in palliative care. Nurses need in-depth knowledge and skills as well as practice within each holistic domain to perform quality treatment of palliative patients.


A transputer supernode system is designed for studying wave scattering in parallel. The processor farm system is enhanced by converting each worker into a supernode comprising a transputer plus two networks of single-processor-boards. Softwares are written to handle low-level tasks for parallel processing. The wave equations are solved by the method of moments. The scatter is represented by a grid of 2/sup n/ wires of equal length. Due to the manifold symmetry, the matrix can be fast enumerated. The matrix is also efficiently inverted by the matrix partition method. An adaptive scheme is used to evenly distribute loading among all processors and minimize inter-processor communications. Significant computational speedup is observed. >


The sustainable livelihoods approach dominates the development discourse as a panacea for poverty reduction. It is an approach premised on the view that it leads to development interventions that capacitate the poor. This article examines the efficacy of food gardening as a sustainable livelihood strategy. The research took the form of a case study. While the insights gleaned, show that food gardening has the potential to lift people out of the poverty trap, the current implementation of food gardens as an anti-poverty strategy is beset with challenges such as, lack of capital; poor access to markets, and inadequate business skills. DOI: 10.5901/mjss.2014.v5n4p597


This paper investigates the relation between graph signal processing and consensus of multi-agent systems. The graph signal processing is a technique to process graph signals, that is, signals whose values are on the vertices of graphs and whose structures are specified by the edges. By considering the combination of the states of agents and the graph describing the network structure between them as a graph signal, we show that the multi-agent consensus corresponds to low-pass filtering of the graph signal. This reveals a connection between the two distinct areas, i.e., the graph signal processing and the control of multi-agent systems. In addition, we provide a design method of consensus controllers based on the graph signal processing. In the proposed method, the controllers of agents are designed so that the spatial frequency of the states of the agents becomes a desired one. This enables us to construct controllers of multi-agent systems in the spatial frequency domain.


(54) SCHEDULING OF INDUSTRIAL (30) Foreign Application Priority Data PRODUCTION PROCESSES Apr. 27, 2004 (EP)........................................ O44052611 (75) Inventors: Alec Stothert, Westborough, MA (US); Andreas Poncet, Zurich (CH) Publication Classification Correspondence Address: BUCHANAN, INGERSOLL & ROONEY PC (51) Int. Cl. POST OFFICE BOX 1404 GOSB 13/02 (2006.01) ALEXANDRIA, VA 22313-1404 (US) (52) U.S. Cl. ................................................................ 7OO/36


The threshold reliability R d of a flow network G can be defined in terms of the flow threshold d as the probability that network G admits a flow of at least d from the source node to the sink node. A fast exact algorithm to evaluate the threshold reliability of flow networks in terms of a sum of disjoint products is presented. In the proposed algorithm, a reliability product can be derived under a branching product in O(m) time using a d-path where m is the number of arcs in the network. Two algorithms are also presented to approximate the threshold reliability by modifying the proposed exact algorithm so that it can be terminated faster but at the cost of a lower accuracy. One is obtained by setting an acceptable difference value between the upper and lower bounds of the threshold reliability as the stopping criterion of the exact algorithm and the other is obtained by searching qualified α–products. Since the threshold reliability problem is NP-hard, approximation algorithms are indispensable for solving moderate and large flow networks. The proposed exact algorithm is verified using experimental data and the performances and properties of the two approximation algorithms are also explored and compared.


The size of all components of the Fontan circuit need to be adequate in order to produce sustainable palliation for patients with functional single ventricle physiology. It is well established that patients with undersized pulmonary arteries (low Nakata index) usually do not fare well in the long-term with Fontan physiology.


The present invention discloses a process of tea Bitan snow, characterized in that: the process includes picking - shipping flowers bud - bud push over - scenting flower - drying - Add Flower identified - fried flower - stem speculation - packaging sales. In addition to having a spring bud quality, the other with a rich fragrance of jasmine and pleasant heart and lung, after opening flower soup identified flying like snow. Tea raw materials for the mountains and spring bud green goose. Raw fresh jasmine buds picked within jasmine green food base.


The purpose of this study was to discover the impact of leadership on organizational performance towards Lincoln University College. The objectives of the study were to investigate leadership's impact and to define the types and concepts of leadership behavior. Different theories of leadership were discussed in this research. This research work consists both qualitative & quantitative research methods. For data collection sources, standard questionnaires were modulated to obtain the necessary information. The questionnaires were then evaluated as per the results summed up, comprising 28 lecturers, 104 students and 21 employees, respectively. The secondary data for this study were collected from Internet and abstract of articles, LUC's Malaysian journal of nursing, library books and Personnel records, related documents and other relevant circulars.The results driven from this research showed and proved that there is a positive relationship between each variable and there is a strong impact of leadership on organizational performance.


Insulin, downstream of Akt activation, promotes glucose uptake into fat and muscle cells to lower postprandial blood glucose, an enforced change in cellular metabolism to maintain glucose homeostasis. This effect is mediated by the Glut4 glucose transporter. Growth factors also enhance glucose uptake to fuel an anabolic metabolism required for tissue growth and repair. This activity is predominantly mediated by the Glut1. Akt is activated by phosphorylation of its kinase and hydrophobic motif (HM) domains. We show that insulin-stimulated Glut4-mediated glucose uptake requires PDPK1 phosphorylation of the kinase domain but not mTORC2 phosphorylation of the HM domain. Nonetheless, an intact HM domain is required for Glut4-mediated glucose uptake. Whereas, Glut1-mediated glucose uptake also requires mTORC2 phosphorylation of the HM domain, demonstrating both phosphorylation-dependent and independent roles of the HM domain in regulating glucose uptake. Thus, mTORC2 links Akt to the distinct physiologic programs related to Glut4 and Glut1-mediated glucose uptake. DOI: http://dx.doi.org/10.7554/eLife.26896.001


Basic clinical diagnosis principles are based on the application of neural networks embedded in the expert system of cerebral potential signal. Analysis of ordinary expert system, development condition and main property of neural networks is provided, in the meantime argumentation of recognition, acquisition, fundamental structure design and intelligent diagnosis is also available in order to explain the effectiveness and advancement of our method.


In this paper, we present a complete optimization loop in order to maximize the efficiency of turbine blades. The optimization of the shape of turbine blades is considered within the context of a whole turbine stage. Thus, also stator/rotor interactions are taken into account. An essential part of the optimization loop is providing gradient information in order to increase efficiency. The derivation of the sensitivity equation and its discretization within the framework of the underlying flow solver is the main part of the paper. The performance of the optimzation loop is demonstrated on a complete turbine stage.


Modern power steering systems employ an electric motor drive system to provide torque assistance to the driver. The closed-loop mechanical system dynamics that impact stability, performance and steering feel are significantly impacted by the electrical dynamics of the actuator depending on the structure and tuning of the motor torque controller. This paper presents an integrated approach to the analysis of this electromechanical dynamic control interaction through mathematical modeling which is confirmed with simulations.


This paper mainly interpreted the unique ethnic customs in Tongdao,and analyzed the local tourism development situation and problems,proposed to be leaded by the government,established benefit sharing mechanisms,integrated tourism resources and enhanced the attractiveness of the area,promoted the tourism development of Dong villages,so as to promote both economy and society development.


Abstract The terrestrial and oceanic sources of moisture that supply warm-season rainfall to the Mississippi River basin and its subbasins are examined over a 36-yr period (1963–98). Using hourly observed precipitation, National Centers for Environmental Prediction (NCEP) reanalyses at 6-h intervals, and a back-trajectory algorithm, the water falling during observed precipitation events is probabilistically traced to its most recent surface evaporative source, terrestrial or oceanic. Maps of these sources generally show dual maxima, one terrestrial and one oceanic, in spring and a dominance of terrestrial sources in summer. Pentad time series averaged over the 36 years show a late-summer maximum of precipitation recycling in all but the Missouri subbasin. During the 36 years analyzed, 32% of warm-season precipitation in the entire Mississippi basin originated as evaporation within the basin (recycled). About 20% of warm-season precipitation was contributed directly by evaporation from the Gulf of Mexico a...


Many aspects of tissue transplantation have been studied,' but there are few reports of dental tissue transplantation. Several reports have dealt with surgical technic,2 9 histopathology,10-"1 transplanted tooth germs,12-16 and transplantation procedures,17-22 but few have considered the immune response to transplanted teeth.23'24 A recent report by Schulman24 suggested that freshly extracted teeth possess transplantation antigens. This was demonstrated by implantation of donor teeth into fascia on the backs of recipient rabbits, which resulted in sensitization of the rabbits and accelerated rejection of subsequent skin grafts from respective tooth donors. In view of available evidence, it is presumed that teeth might possess transplantation antigens capable of stimulating a second-set reaction when allografted to orthotopic sites. In the few studies concerned with immune mechanisms associated with tooth transplantation, orthotopic sites for teeth were not chosen. Deductions may be made from observations of implants of teeth under the skin of an animal's back; however, the bony alveoli of the mouth would be a more realistic site and would provide a more satisfactory basis for conclusions. In previous experiments, whole, intact teeth were utilized for immunologic work. It would be interesting to know how much antigenicity might be contributed by the hard and soft fractions of teeth. From a clinical standpoint, a tooth transplant might be more successful if the soft tissue were removed from the tooth before transplantation, for example. It was the purpose of this investigation to evaluate the capacity of soft and hard dental


It is intended to provide a processing liquid for resist substrates, which makes it possible to simultaneously and readily solve the problems of foreign matters sticking to pattern surface, pattern inversion and pattern roughness, and a pattern formation method using the same. This processing liquid for resist substrates contains a primary amine or an ammonia alkylene oxide adduct having a hydrocarbon group carrying from 11 to 30 carbon atoms together with water. The pattern formation method as described above comprises processing a developed pattern with the use of the processing liquid for resist substrates.


This thesis will analyze video from land-based, cooled mid-wave infrared cameras to identify temporal features indicative of a heat plume from a forest fire. Desirable features and methods will show an ability to distinguish between heat plume movement and other movements, such as foliage, vehicles, humans, and birds in flight. Features will be constructed primarily using combinations of statistics and principal component analysis (PCA) with intent to detect key characteristics of fire and heat plume: persistence and growth. Several classification systems will combine and filter the features in an attempt to classify pixels as either heat or non-heat. The classification systems will be tuned and compared with common metrics of error rate and computation time. It was found that the movement pattern of a heat plume could be distinguished from the similar movement pattern of foliage by detecting outlier movement patterns, a phenomenon associated with the growth property of fire. Outlier movement patterns were best detected by thresholding the quotient of mean and median of a set of variance measurements over time. The best tested classifier in terms of minimizing false positives without losing the heat signal came from PCA of a dual-range moving average difference. ACKNOWLEDGEMENTS Dr. Saghri and Dr. Jacobs offered their insights and experience throughout this entire project. It wouldn't be what it is without their dedication and passion. Thank you to the Raytheon and FLIR employees who generously volunteered their weekend time to configure and facilitate the data collection mission:


Existing feedback schemes of Channel State Information (CSI) in OFDMA systems can be mainly sorted into two categories as follows: 1) sounding channel feedback, and 2) precoder matrix indicator (PMI) feedback. However, both these two categories have some performance drawbacks and limitation of usage. In this paper, two Sounding-based Phase Feedback (SPF) schemes, namely, Type_1 SPF and Type_2 SPF, are proposed as alternatives of CSI feedback methods. With the proposed feedback schemes, the OFDMA transmitters can obtain the information of channel phases and perform an approximate Equal Gain Combining (EGC) transmission. Comparing to the current sounding channel feedback schemes, these two schemes have the flexibility to be employed in both TDD and FDD modes with comparable overhead. Comparing to the PMI feedback scheme, the proposed schemes have lower computation complexity at the receiver sides since the procedures to find the optimal precoder is not needed. Moreover, the fundamental performance limit due to quantizing the channel status also does not exist in the proposed schemes. Theoretically, the proposed schemes could convey near perfect channel phase information if appropriate estimation algorithms are adopted in the transmitter for channel estimation. Numerical analysis is also provided to evaluate the average receive SNR achieved by the two proposed schemes for comparing their performance under nonideal channel estimations. Simulation results show that the performance of the proposed schemes can achieve close performance to that of EGC (within 0.5 dB) which needs perfect channel phase information at the transmitter.


For many decades now, the idea of Vortex-Induced Vibrations (VIV) being modeled as a lock-in phenomenon of a mass-spring-dashpot system with an ideal added mass term has prevailed. In 2000, it was suggested by Vikestad et al. [1] that VIV may be modeled as a resonance phenomenon with variable natural frequency due to a variable added-mass term. In this paper, the variable added-mass approach is used for analysis of VIV at various added damping values. Additionally, Vandiver's damping coefficient c* is used [2] to correlate damping to lift. The findings are that: 1. The oscillation frequency is in unity with the mean of the natural frequency with variable added mass for each period of oscillation during VIV lock-in no matter the damping value. 2. The time-averaged variable added mass coefficient is shown to vary with an increasing damping coefficient, where below a reduced velocity of approximately seven, increased damping indicates increased added mass. After a reduced velocity of approximately seven, however, increased damping results in decreased added mass. 3. Vandiver's damping coefficient c* plotted against the nondimensional amplitude follows very closely to c*A/D = max lift coefficient = square root of 0.79 [3]. A handful of cases did exceed square root of 0.79 but only marginally.


In this article, substoichiometric titanium oxide thin films (TiOX) are prepared with the reactive DC sputtering in an oxygen and argon atmosphere and then annealed in an oxygen atmosphere. Under a set of optimum deposition parameters, TiOX film with sheet resistance value of 167.9 KΩ/(box) and TCR value of -3.30%/K obtained. Transmittance of the optimum film is obtained in the 300≤λ≤1100nm wavelength range at room temperature. Thickness, near-infrared absorptance, and other properties of the optimum film are also investigated in this paper.


Twelve compounds unknown in the literature N-(E)-2-stilbenyloxymethylenecarbonyl substituted hydrazones of 2-, 3- and 4-pyridinecarboxaldehydes, as well as methyl-3-pyridylketone have been prepared. The stereochemical behavior of these compounds in dimethyl-d6 sulfoxide solution has been studied by 1H NMR technique. The E geometrical isomers and cis/trans amide conformers have been found for N-substituted hydrazones 1–12. EI induced mass spectral fragmentation of these compounds were also investigated. The data obtained create the basis for distinguishing isomers.


ahAa Ta fl' 1717rOf\ftrp Tf I\Ot7rT]naAtKa raw~ n~ MatKl)l'a~, O'VTJpL7r7rfV~, Kat TOTE ,'1 ;){ ~'" -' ~ ~. . Kat f7rfLTaf7rL7rOI\V utWKI)C1fl' [But a certain GalUSMaecenas, an equestnan, handled the affairs both in the city ~d in the rest of Italy, both then and afterwards for a long time] (Dio.49.16.2); the phrase Ka~ ~lmmhI. 7rOA~[and afterwards for a long time] indicates that there were two periods of administration and refers to the one in 31 Be. This time is more or less confirmed by Tacitus, who states that Octavian placed Maecenas in charge of Rome and Italy during the Civil Wars (Tac.Ann.6.11.3), after leaving the army for the second time (Andre 1976:64 and 67). Maecenas' administration of Rome and Italy in 36 BC must have ended by 13 November, when Octavian's ovatio was celebrated (Reinhold 1988:41); Reinhold suggests that his administration was from 3 July either for four months until November or for two periods, that is from July for a month and then from the middle


This paper uses systems psychodynamic concepts to develop theory about the persistence of racial inequality in U.S. organizations and to inform an approach for disrupting it. We treat White men who aspire to emulate hegemonic masculine ideals as the dominant group and Black people as the archetypal subordinate group. In our theory, persistence is rooted in work contexts that conflate merit with idealized images of White masculinity, which provokes unconscious distress in White men who aspire to meet those ideals. To keep this distress at bay, they covertly construct an unconscious, multilevel defense system, comprising projective identification at the individual level bolstered by a social defense at the organization level. This system is selfsealing: It diverts attention away from the real culprit—work contexts that threaten White men's self-worth—by contriving a substitute problem—a shortage of meritorious Black people; at the same time, the social defense fuels aspects of the work context that give rise to such threats in the first place. The upshot is the persistence of racial inequality. We offer guidance on how to disrupt these dynamics by building mutually-reinforcing holding environments where organization members can engage in intrapsychic and intergroup reparative work. We conclude by offering theoretical contributions to organizational inequality, systems psychodynamics, and masculinity literatures.


To promote China's research on fields related to high-accuracy gravity measurement, the Institute of Electrical Engineering, Chinese Academy of Sciences (IEECAS), is committed to developing superconducting gravimeters. A superconducting gravimeter prototype has been successfully designed, fabricated, and tested through continuous improvement and optimization design. This article describes the main components of the prototype: superconducting gravity sensor, magnetic shield, cryogenic system, and displacement detection and feedback system. The novel work improves the superconducting gravity sensor on the persistent current switch and superconducting joint. Furthermore, the method for testing the levitation stiffness is also introduced, and the result demonstrates that an electromagnetic force method is a feasible approach with fast and good linearity. Finally, experimental test results on the prototype are shown, where solid Earth tide, temperature effect, and parasitic mode are obtained in the prototype signal. Moreover, it is shown that the levitation stiffness obtained by the electromagnetic force method and the tidal observation method are close to each other.


Interest in biological clock pathways in bipolar disorders (BD) continues to grow, but there has yet to be an audit of circadian measurement tools for use in BD research and practice.


For bituminous mixes, determination of bitumen content is considered to be one of the important facets of quality control during highway and airfield construction, and is achieved by extracting bitumen from the bituminous mix. In this paper the possibility of using kerosene oil as a solvent in the extraction of bitumen from bituminous mixes is explored. The possibility of using diesel oil for coarse mixes is also examined. Results based on the experimental data are presented. It is concluded that kerosene oil can be used as a solvent for dense mixes with cement as a filler. Use of kerosene oil for mixes where limestone dust is used as a filler is not recommended. For open graded mixes, kerosene oil gives better results as compared to those for dense mixes. Use of diesel oil has also not been found suitable as a solvent in the extraction of bitumen from bituminous mixes. (TRRL)


This article provides a typology ofreasons for conducting m i x ed - m et h ods re se a rch in spe cial edu c a ti o n .The mixed methods research process is described along with the role ofthe rationale and purpose ofstudy.The reasons given in the literature for utilizing mixed-methods research are explicated,and the limitations ofthese reason frameworks are identified.We build on these frameworks by providing a comprehensive list of reasons for conducting mixed-methods research.The reasons provided in our model are operationalized in the context ofspecial education and,thus,complement the goals ofspecial education re se a rch ers .Fi n a lly,we pre sent a fou r- d i m en s i o n a l Rationale and Purpose (RAP) model demonstrating how investigations can be designed according to the rationale for using mixed methods,purpose ofmixing,stage ofstudy where mixing occurs,and emphasis ofapproach derived from the research question(s).


This letter studies the problem of distributionally robust model predictive control (MPC) using total variation distance ambiguity sets. For a discrete-time linear system with additive disturbances, we provide a conditional value-at-risk reformulation of the MPC optimization problem that is distributionally robust in the expected cost and chance constraints. The distributionally robust chance constraint is over-approximated as a simpler, tightened chance constraint that reduces the computational burden. Numerical experiments support our results on probabilistic guarantees and computational efficiency.


The yield and robustness of carbon-based embedded memory can be significantly degraded by the presence of metallic carbon nanotubes (m-CNs) that create short circuits in the channel arrays of CN-MOSFETs. The malfunction caused by these short circuits can be avoided by removing the m-CNs using specialized etching techniques. During the removal of metallic nanotubes, however, residual m-CNs may be left in the channel arrays of some of the transistors. Furthermore, all of the nanotubes may be etched in some of the channel arrays, thereby causing permanent open circuits and malfunction. A statistical design methodology that considers all of these possibilities related to the formation and removal of metallic nanotubes is needed for achieving functional memory circuits with high yield despite fabrication imperfections in carbon-based electronics. An m-CN-removal-tolerant high-yield six-transistor (6T) static random access memory (SRAM) cell is proposed in this paper considering the nonidealities of CN-MOSFET fabrication. A general statistical functional yield model of memory arrays with 6T SRAM cells is developed by comprehensively considering the spatial correlations among different transistors. The yield of the m-CN-removal-tolerant memory array is increased by 131 times, and read access speed is enhanced by 16.42% as compared with the standard design that does not provide any tolerance to the removal of m-CNs in a 16-nm CN transistor technology.


This article reports on a study that examined the choice and use of academic reading strategies of adult learners who were identified as proficient and less proficient readers. The major objective was to explore the potential influence of their adult characteristics on their use of their academic reading strategies. Data were gathered using student diaries, participant observations, and think-aloud protocols. In addition, the take-home reading handouts were studied and retrospective interviews were conducted immediately after the think-aloud protocols. Data analysis was done at two levels: quantitative and qualitative. While the quantitative analysis yielded the variety and frequency count of the strategies used, the qualitative analysis provided the quality of and reasons for the choice and use of the strategies. Quantitative analysis resulted in the identification of 31 cognitive strategies, 20 metacognitive strategies, and 5 affective strategies amongst the proficient readers, and 26 cognitive strategies, 15 metacognitive strategies, and 6 affective strategies amongst the less proficient readers. The qualitative analysis revealed that the proficient readers were found to be able to manipulate their common characteristics as adult learners to the advantage of their academic reading, while the less proficient readers were found to be ignorant of the potentials of their common characteristics as adult learners. The findings of this study have direct implications on the teaching of academic reading to adult learners and the design of the academic reading curriculum in adult education.


A correct system specification is systematically obtained from the essential user requirements model by applying a set of rules, which give a formal semantics to the graphical analysis entities of SA/RT. The aim of the systematic procedure is to establish the methodological infrastructure necessary for deriving a complete system specification of a given real-time system in terms of CSP+T processes. A detailed complete solution to the Production Cell problem is discussed, showing how the method can be applied to solve a realworld industrial problem.


Multiple myeloma (MM) is a human cancer of malignant plasma cells. Recent genomic studies have started to catalog all the genetic alterations in selected panels of MM samples, and, within a short period of time, the large majority of MM-associated genetic and transcriptional alterations will have been identified. These recent insights, on one hand, indicate that MMs can harbor extensive clonal heterogeneity, and, on the other hand, they will help to reconstruct the molecular ontogeny of the disease's evolution (i.e., the clonal architecture of each individual MM). However, a pending challenge is to delineate the stages of hematopoietic differentiation at which the individual genetic alterations arise, or, in other words, to elucidate the cellular architecture of MM.

In the classical view of the initiation and progression of MM, an initiating genetic alteration is required to immortalize a plasma cell (Fig. 1A). Such cell is then destined to acquire additional genetics hits over time. The acquisition of additional hits further deregulates the behavior of the plasma cells, thus leading to the clinically recognized features of MM, including the lytic bone lesions. In this classical model, MM is therefore a disease arising from mutations occurring in an already differentiated plasma cell. However, in the last years it has been shown that cellular heterogeneity is also a feature of human MM. Indeed, by studying the engraftment of primary MM specimens in immunodeficient mice, it was found that tumor plasma cells were unable of engraftment following intravenous injection,1 suggesting that the MM-propagating/maintaining cell was not a tumor plasma cell. Therefore, an essential gap that must be covered in order to define the cellular architecture of MM is the identification of the nature of the MM cell of origin. In fact, in spite of the assumptions of the above-mentioned classical view of MM origin, very little is still known about the cancer cell of origin from which MM arises and about how the initial genetic lesion(s) regulate this essential step. These initial genetic lesions have always been detected in differentiated tumoral plasma cells, although the presence of a human myeloma stem cell was postulated many years ago.2 It is true that the patient's hematopoietic progenitor and stem cells (HS/PCs) seem not to show any of the initiating genetic alterations detected in tumor plasma cells; however, it is also true that these alterations would be very difficult to detect if the frequency of these putative stem cells harboring the MM-inducing genetic lesion was low. Therefore, due to this purely statistical reason, experimental results would seem to suggest that the MM cell of origin is not a stem/progenitor cell. However, until now, all the experiments in which the expression of human MM-linked oncogenes is targeted to the mouse differentiated B cell compartment have failed to reproduce the human disease in mice. Therefore, it is potentially possible that in human patients, the occurrence of MM-associated oncogenic alterations might happen in the HS/PCs compartment, and this cell of origin adopts/acquires afterwards a MM cell fate as a consequence of the oncogene activity.

Figure 1. Cellular architecture and multiple myeloma (MM) development. (A) Current working model for the development of MM in humans. In the current view of the initiation and progression of MM, an initiating hit is required to immortalize a plasma ...

To elucidate if MM is a stem cell-driven tissue, we initially focused on the effects of the MafB oncogene, since the MAF family of proteins seems to be implicated in 50% of human MM. In consequence, we have developed mice in which we limited MafB expression to the mouse HS/PCs Sca1+ cells.3 In human MM and in most animal models of cancer,4 the oncogenic alterations are expressed in all the cellular types that compose the tumoral tissue, from the MM stem cell to the terminal differentiated plasma cells. In our stem cell-driven Sca1-MafB model, the expression of MafB is restricted to the HS/PCs compartment, but this restricted expression pattern is nevertheless capable of generating a full-blown MM with all its differentiated cellular components, in such a way that Sca1-MafB mice share both major and minor diagnostic criteria with the human pathology. The demonstration that MM development can be established in mice by expressing MafB only in Sca1+ cells implies that MafB can impose a gene regulatory state in these stem cells that somehow persists during hematopoiesis, and that can program a tumor plasma cell phenotype symptomatic of MM. This is an observation that seems to apply to other cancer-initiating gene defects.5-10 In the oncogenic reprogramming model here presented, the reprogrammed Sca1+ population can nevertheless complete a multi-stage differentiation pathway involving an initial commitment to the B cell lineage and a subsequent differentiation to tumor plasma cells.3 This model of MM is very informative with respect to the fact that the oncogenic mutations can have different roles in MM stem cells vs. differentiated tumor plasma cells. Thus, genetically distinct MM stem cell subclones may exist on top of each MM tumor mass, revealing an even higher complex cellular composition of MM than initially thought (Fig. 1B).

In order to gain even more insight into the mechanism by which MafB can induce the reprogramming of stem cells into tumor plasma cells, we have also generated in vivo genome-scale maps of DNA methylation from both stem cells and mature B cells from Sca1-MafB mice.3 We found that a substantial number of CpG islands and promoters are specifically hypermethylated or hypomethylated in the stem cells of Sca1-MafB mice, setting a pattern inherited throughout B cell development. Thus, the results presented in our study demonstrate a novel molecular mechanism involved in tumor initiation, by showing that HS/PCs can be epigenetically reprogrammed to give rise to terminally differentiated tumor plasma cells by MafB.3 To our knowledge, these results represent the most convincing evidence to date that MM development can arise and be driven by a tumor cell fate change within the stem cells. These findings represent a novel paradigm in MM biology and will revolutionize the current modeling of MM tumorigenesis and progression and are likely to have profound therapeutic implications (Fig. 1C).


The neurochemical organization of the striosomal compartment in the human striatum was analyzed by histochemical and immunohistochemical techniques applied to postmortem tissue from normal individuals. The striosomes were delineated by using the following markers: acetylcholinesterase (AChE), enkephalin (ENK), substance P (SP), calbindin‐D28k (CB), parvalbumin (PV), calretinin (CR), limbic system‐associated membrane protein (LAMP), choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and NADPH‐diaphorase. Comparisons were made between striosomal boundaries, as outlined by each marker applied on adjacent sections, and particular attention was paid to possible variations in the chemical features of striosomes along the rostrocaudal extent of the striatum. The main findings of this study are as follows: 1) the striosomal compartment is composed of two chemically distinct domains: a core and a peripheral region; 2) the core is largely devoid of CB and displays a less intense staining for ENK and LAMP than the peripheral region; 3) although striosomes are largely devoid of AChE, the activity of this enzyme is slightly higher in the core than in the peripheral region; 4) the core and peripheral regions are weakly stained for PV and intensely stained for SP; 5) ChAT‐, CR‐ and NADPH‐diaphorase‐positive neurons are preferentially distributed in the peripheral region; 6) at rostral striatal levels, striosomes are largely devoid of TH, whereas the inverse is true caudally; and 7) at caudal striatal levels, the peripheral region of striosomes is intensely stained for CB and ChAT. These results demonstrate that the striosomes in human display a strikingly complex and heterogeneous chemical architecture. J. Comp. Neurol. 413:603–618, 1999. © 1999 Wiley‐Liss, Inc.


Treatment of oesophageal high-grade dysplasia is one of the great conundrums facing oesophageal surgeons. Both authors allude to the uncertainty of the natural history of high-grade dysplasia, especially the rate of progression to invasive cancer and furthermore to the variation in reported incidence of carcinoma in post oesophagectomy resections for high-grade dysplasia.

Professor Barr adopts the minimalist approach – favouring local ablative therapy (such as photodynamic therapy or endoscopic mucosal resection [EMR]) and endoscopic surveillance – postulating these inconveniences are better than death or life-long morbidity following oesophagectomy for a pathologically variable disease.

Mr Maynard quotes very impressive mortality following transhiatal oesophagectomy and rightly alludes to the fact that increasing depth of mucosal neoplasia equates to higher nodal disease with consequent reduction in survival from higher tumour stage.

What is the correct approach? Probably the answer will lie in increased use of EMR: this will enable better pretreatment staging and identification of patients with multifocal disease. Those whom are fit, have multifocal long-segment disease and with extending depths of neoplasia on EMR histology might fare best with surgical resection. The unfit with short-segment, superficial disease may suffice with endoscopic therapy/surveillance.

Tom Dehn


Supplemental Digital Content is Available in the Text. Background: Lid fatigability test (LFT), Cogan lid twitch (CLT), and forced eyelids closure test (FECT) are simple clinical screening tests for ocular myasthenia gravis (OMG). However, these tests are subjectively interpreted. We thus evaluated the interobserver and intra-observer reliability of each test. Methods: The 3 eyelid tests were performed in ptotic patients associated with various conditions, including OMG and others. Video clips of all tests were recorded using smartphone with built-in camera in the following order; LFT, CLT, and FECT. All video clips were distributed to 3 neuro-ophthalmologists and 3 general ophthalmologists, who were trained to evaluate the tests using a single standard instruction. After 3 months, all video clips were re-organized for the second evaluation. Interobserver and intra-observer reliability were calculated using Cohens' Kappa coefficient and Fleiss Kappa statistic. Results: The 3 eyelid tests were performed and recorded in 35 patients, which included the diagnosis of OMG, levator muscle dehiscence, partial oculomotor nerve palsy, and Horner syndrome. CLT received moderate-to-substantial interobserver reliability in neuro-ophthalmologist group (Fleiss Kappa 0.77 [95% CI 0.60–0.94] and 0.66 [95% CI 0.46–0.85] in first and second evaluation respectively), but the results varied in general ophthalmologist group (Fleiss Kappa 0.58 [95% CI 0.37–0.79] and 0.54 [95% CI 0.33–0.76] in first and second evaluation respectively). FECT and LFT received lower interobserver reliability in both groups. CLT also received moderate-to-almost perfect intra-observer reliability in neuro-ophthalmologist group (Cohen Kappa 0.55, 0.58, and 0.92), whereas FECT and LFT received lower intra-observer reliability. The intra-observer reliability varied among general ophthalmologists for all 3 eyelid tests. Conclusions: CLT is the most reliable test among the 3 eyelid tests. However, all tests should be interpreted with caution by general ophthalmologists.


ABSTRACT The number of students reporting dyslexia in HE institutions is increasing year on year, mirroring institutional inclusivity agendas. This article investigates the potential for a universal (but not sole) approach to teaching dyslexic learners across disciplines, institutions and academic content. The article discusses a largely unexplored nexus between commonly compromised working memory in many dyslexic learners, on the one hand; on the other, the scientifically validated capacity of multimedia learning (MML) methods to ease pressure on working memory by exploiting visual processing capacity. It advances this literature in two areas. First, MML's focus on cognitive engagement neglects the affective and behavioural dimensions of engagement. Second, MML methods have not been tested coherently with dyslexic learners. A speculative hypothesis, therefore, asks how the use of MML methods might affect each dimension of engagement for dyslexic learners. A replicable mixed methods longitudinal randomised control group trial was devised, with the subjects being dyslexic learners in nine disciplines at a UK university. The resulting data confirms that MML enhances engagement across each dimension to varying degrees, and that the key increases were not in the domain of cognitive engagement. Further, it shows that dyslexic learners' engagement across the spectrum is greater when exposed to multimedia methods than monomedia.


At Berkeley, California, main ionic constituents of bulk precipitation during the wet season of 1974–1975 were SO₄²⁻, Cl⁻, HCO₃⁻, Na⁺, and Ca²⁺, and mean H⁺ concentration was 10.7 ± 1.5 µeq/liter (pH 5.0). Although SO₄²⁻ comprised 50% of the anions in bulk precipitation, H⁺ concentration had the highest correlation with NO₃⁻. Impacted air pollutants accumulated on tree leaves between major rainstorms. Atmospheric N and S were correlated with NO₃⁻ and SO₄²⁻ in bulk precipitation and leafwash in a Eucalyptus globulus forest. Ionic composition of bulk precipitation resembled that of surface-soil solution in an adjoining, recently clear-cut area.


The study explores the integration and implementation of the Moodle platform at the English Language Center of the Salalah College of Technology. To achieve this purpose, a qualitative, interpretive approach with a case study research design was used to collect the data and to deepen our understanding of the phenomena and how it was constructed in social reality of the school.Two teachers have been chosen to be the interviewees, to give their opinions and views on the topic under study, and the factors affecting both the implementation and integration of the Moodle programme. It was evident from the narratives of the two interviewees that the integration of Moodle was successful, and that it has proven to be a useful tool in the teaching and learning processes of English. In spite of some existing factors that may hinder the working mechanisms of the implementation and integration of Moodle, it may be concluded that this platform could be recommended to be extended to the other skills of the English language that it currently does not support. Following this process will inevitably improve the comprehension and production of the English language and related materials, online and real, respectively.


Purpose – Outlines and reports on a radical new approach to developing both an organization and its people to enable those people to be themselves in body, mind and spirit while at work and so feel fulfilled – and, in the process, enable the organization to be more successful.Design/methodology/approach – Outlines the philosophy of Ecumenical Partnership Initiatives Compassion in Change (EPICC), a part of Workplace Matters; summarizes key industry trends identified in relevant research, and sets out EPICC's question‐based approach to achieving its clients' goals.Findings – Reports research findings that only 20 percent of employees in large organizations feel their strengths are used every day and eight out of ten employees feel miscast in their job. Outlines a new way of business thinking with regard to human resources and development. Reports that, when dealing with business issues within the social paradigm, it is important to be open to things of the spirit.Practical implications – Describes how peopl...


Application of systemic approach as implemented in logistics allows attaining an economic effect. Using logistics as a traffic management and safety-ensuring tool allows representing road traffic as a unified flow accompanied with other flows. It allows justifying adaptive control of traffic and road building and reconstruction processes for attaining a common goal: timely and exhaustive provision of road carrying capacity.


Left‐sided portal hypertension is usually found in patients undergoing pancreaticoduodenectomy (PD) with spleno‐mesenterico‐portal (S‐M‐P) confluence resection. This study is to explore the outcomes of S‐M‐P confluence reconstruction after resection by using bifurcated allogeneic vein.


This research was conducted to analyze the effect of service quality to satisfaction of patients treated at the healthy center in Desa Pasir utama. The samples in this research are 44 respondents. There were methods of sampling used the technique Accidentals also. The method analysis was quantitative analysis used validity test, reliability test, simple linear regression analysis, the correlation coefficient, coefficient of determination, and hypothesis testing. Used simple linear regression analysis concluded that service quality effect on patient satisfaction, it can be seen from the results of the regression equation with the result Y = 4,421+ 0,589XX, value indicates that the X or the service quality effect on customer satisfaction by 0.589 or 58.9%. Based on the calculation of correlation coefficients obtained results sig (2-tailed) of 0.058 means that the relationships between the two variables are low. The coefficient of determination shows the influence of variable X to variable Y is strong. Hypothesis test figures obtained significance of 0.000. It means that there were influenced quality of service to the satisfaction of the patient, because 0,000 <0.05 it means the value of regression is feasible or correct. It is recommended to the chairman of the health center in Desa Pasir Utama to be more concerned about the quality of services provided by employees of health centers so that patients get satisfaction in accordance with what they expect, and the need for modern facilities in order to hold a health center can be trusted by the local community.


The photoluminescence and electroluminescence behaviors of four types of pyrazoline compounds of different structures dissolved in solution or composed as a dopping dye in the EL device have been studied in this work. Results indicated that the non - cyclic hydrazone compound containing the same conjugated moiety as in pyrazoline is unable to emit strong fluorescence either in solution or in solid film. But, for the pyrazoline compound very strong luminescence can be observed when it was measured in both conditions described above. The pyrazoline compounds with phenyl group at 5 - position possess excellent property of film formation due to the difficulty in crystallization. On the contrary, the pyrazoline compound without phenyl group at 5 - position is unadaptable to preparing EL device, because the layer contained those compounds collapse rapidly due to crystallization.


This paper examines the differing philosophy of free software and open source software, exploring how they have affected software development, access to fundamental software infrastructure, and the development of the concept of freedom.


The transcription factor HOXB4 not only plays a role during nephrogenesis, but displays also oncogenic characteristics in different malignant neoplasms. An in‐silico analysis revealed HOXB4 as a new target of microRNA‐23a (miR‐23a). Nephroblastomas are malignant embryonal renal neoplasms of childhood resembling developing kidney morphologically and genetically. In our study we verified HOXB4 as a target of miR‐23a and furthermore examined the expression of HOXB4 and miR‐23a in nephroblastomas. We investigated binding of miR‐23a to the 3'UTR of HOXB4 by a luciferase assay. Effects on protein levels of HOXB4 were analysed in Western blot experiments. Expression of HOXB4 in nephroblastomas was assessed by quantitative REALtime PCR (qRT PCR) and immunohistochemistry. The luciferase reporter assay showed a statistically significant downregulation of activity by 72,5% demonstrating direct binding of miR‐23a to the 3'UTR of HOXB4. In addition, miR‐23a reduced the protein expression of HOXB4 statistically significantly by 65.1%. All 21 nephroblastomas investigated had statistically significantly decreased expression levels of miR‐23a. A high level of HOXB4 mRNA was found in five out of 33 nephroblastomas including mixed, blastema‐type and stroma‐type tumors. Protein expression of HOXB4 was stronger in 15 out of 27 nephroblastomas of all subtypes in a semiquantitative comparison to normal kidney parenchyma. Our study demonstrates for the first time the regulation of HOXB4 by miR‐23a. In comparison to mature kidney, nephroblastomas had low levels of miR‐23a, and in a majority of them a stronger protein expression in comparison to mature kidney was found. © 2013 Wiley Periodicals, Inc.


The study of the natural infection of aphid and the insect-resistant assay of transgenic ChIFN-γ tobacco in field verified that transgenic tobacco demonstrated a significant enhancement in insect resistance.To reveal the mechanism of the insect resistance to the transgenic ChIFN-γ tobacco,the content of nicotine in the transgenic leaves was determined and the tissue stained technique was carried out.No significant difference was obtained in the contents of nicotine between the transgene and wild type.However,the leaf thickness,cell density,cell wall thickness of the transgenic tobacco showed an improved trend in the transgenes,which might suggest that these parameters probably contributed to the positive resistance to tobacco aphids and Spodoptera litura larvae.


ABSTRACT: The Citanduy II Project9s model farm program on steep slopes in West Java was started in 1981 with the dual goals of reducing erosion and increasing farmer incomes. Both goals appear to have been reached. However, input requirements and output restrictions of the program reduced the farmers ability to respond to changing market conditions and, consequently, reduced the success of the project in increasing net incomes.


STUDY DESIGN
A cross-sectional study.

OBJECTIVE
To translate and cross-culturally adapt Copenhagen Neck Function Disability Scale into a Simplified Chinese version (CNFDS-C), and evaluate the reliability and validity of CNFDS-C in patients with non-specific chronic neck pain.

SUMMARY OF BACKGROUND DATA
The CNFDS is a reliable and valid evaluation instrument for chronic neck pain. However, Simplified Chinese version of CNFDS hasn't been validated.

METHODS
A total of 150 participants were included in this study. Internal consistency was estimated according to Cronbach's alpha. Test-retest reliability was assessed by Intra-class correlation coefficient (ICC). Construct validity was analyzed by correlations between CNFDS-C and the Neck Disability Index (NDI), Visual analogue scale (VAS) as well as the short form (36) health survey (SF-36).

RESULTS
The original version of the CNFDS was cross-culturally adapted and translated into Simplified Chinese. CNFDS-C was indicated to have excellent reliability (Cronbach's alpha = 0.810, ICC = 0.927). Moderate to substantial correlations between CNFDS-C and NDI (r = 0.642, p < 0.001), VAS (r = 0.581, p < 0.001), as well as physical function (r = -0.583, p < .001), role physical (r = -0.478, p < 0.001), bodily pain (r = -0.610, p < 0.001) and general health (r = -0.439, p < 0.001) subscales of SF-36 were observed.

CONCLUSION
CNFDS-C was demonstrated to have acceptable reliability and validity in patients with non-specific chronic neck pain, which could be recommended for patients in Chinese mainland.Level of Evidence: 3.


In response to an announcement of opportunity from NASA's Science Mission Directorate (SMD) Discovery Program, the Southwest Research Institute in collaboration with the Aerospace Corporation and the NASA Johnson Space Center (JSC) proposed a lunar lander science mission. The Moon Age and Regolith Explorer (MARE) would use a lunar lander to reach a young, nearside lunar lava flow for the collection and analysis of the lunar soil. This would be used for the determination of the impact history of the inner solar system and the evolution and differentiation of the interiors of one-plate planets. The lunar lander proposed was based on the NASA JSC Morpheus lander vehicle. The thermal environments for the proposed mission were both challenging and unprecedented, since survival of multiple lunar day/night cycles at the south-west region of the Aristarchus plateau were required. Other thermal design challenges included the need for a low mass, robust and reliable thermal management system that would assure the success of the proposed mission. As part of the proposal effort, and leveraging on existing NASA Small Business Innovative Research (SBIR), a completely passive thermal control system concept was used to meet mission requirements. The thermal management system proposed uses a novel type of hybrid grooved and sintered wick variable conductance heat pipe and a high conductivity heat spreader; the thermal management systems tested were developed by Advanced Cooling Technologies, Inc. (ACT) in Lancaster, Pennsylvania. This publication will present the design, analysis and prototype component and system level performance testing done at NASA JSC.


105 younger non lactating and non pregnant water buffaloes (Bubalus bubalis) apparently healthy, were studied. Negative results to haemoparasites studied were observed. A blood
sample was taken in the morning by venepuncture of the yugular vein. The blood was colected in tubes and added with sodium EDTA for a concentration of 1-2mglml; and processed within 24 hours. The hemocytometer method was used for determination of erythrocytes (ER), leukocytes (LEU) and platelets (PQ); packed cell volume (VCA) was determined by the microhematocrit technique and the hemoglobin (Hb) by the cianmethahemoglobine method. The Wintrobe indexes were calculated: mean corpuscular volume (VCM), mean corpuscular hemoglobin (HbCM) and the mean corpuscular hemoglobin concentration (CHbCM). Data were processed using the Statistical Analysis System Program (SAS). The quadratics adjusted means ± the standard error of them were: ER 7,499,323 ± 56,270 for μl, LEU 12,424 f 148 μl and PQ 648,086 ± 6,032 by μl, the VCA was 36.94 ± 0.14% and the Hb was 11.05 ± 0.10 g%. The VCM was 51.77 ± 0.34 μ3, the HbCM 16.06 ± 0.21 pg and the CHbCM 31.47 ± 0.31 g%. The ER, VCA and Hb concentration were higher in females; older and heavier animals the ER decreased. The PQ were higher in buffaloes heavier. Non very well trends were exhibited by the LEU.


Objective:To Observe the Change of β2-Microglobulin(β2-MG),Creatinine and Urea Nitrogen in Patients with Various Stage of Elderly Essential Hypertension,and to explore the significance of urine β2-microglobulin in the early diagnosis of kidney damage in elderly hypertensive patients.Methods:Plasma and urine β2-MG were measured by radioimmunoassay(RIA) in elderly hypertensive patients 134 cases(48 cases of stage I hypertension,Ⅱ period of 45 cases,Ⅲ period of 41 cases),and aged 40 cases as normal controls.Results:Ⅰ period of high blood pressure group than normal β2-MG increased(P0.05),Ⅱ period and Ⅲ period hematuria β2-MG were increased(P0.01).Conclusions:Early determination of urine β2-MG in the early diagnosis of renal damage in elderly hypertensive must have the reference value.


Sarcomas are a rare form of malignant tumor, with less than 15,000 new cases being diagnosed each year in the United States. In spite of their rarity, sarcomas are highly debilitating malignancies that are often associated with significant morbidity and mortality. They are also biologically very heterogeneous because they originate from many different tissues and cell types. Sarcomas have classically been defined by their tissue of origin and are additionally stratified according to their histopathology or the age of the patient at diagnosis. Uterine mesenchymal tumors that develop in the myometrium have traditionally been divided into benign uterine usual LMA, cellular LMA and malignant Ut-LMS based on cytological atypia, mitotic activity and other criteria. Ut-LMS is relatively rare, having an estimated annual incidence of 0.64 per 100,000 women [1], and is resistant to chemotherapy and radiotherapy; therefore, surgical interventions are virtually the only means of treatment [2, 3]. The prognosis of patients with Ut-LMS is poor, and the 5-year survival rate is approximately 35%. Uterine LMA may occur in 70-80% of women by the age of 50 years [4]. Difficulties have been reported in distinguishing Ut-LMS from other uterine mesenchymal tumors including uterine LMA, and a diagnosis generally requires surgery and cytoscopy. Diagnostic categories for uterine mesenchymal tumors and morphological criteria are used to assign cases. The non-standard subtypes of uterine mesenchymal tumors such as the epithelioid and myxoid types are classified in a different manner using these features; therefore, a diagnostic method needs to be established that can identify non-standard smooth muscle differentiation [5, 6]. High estrogen levels have been shown to significantly influence the development of tumors in the uterine body [7]. However, the molecular mechanisms underlying the transformation of uterine LMA and development of Ut-LMS remain unknown. Tumors that have developed and grown in the myometrium increase in size due to the influence of the female hormone, estrogen, which leads to the generation of more tumors. However, a relationship has not yet been reported between the development of Ut-LMS and hormonal conditions, and no obvious risk factors have been identified. The identification of risk factors associated with the development of human Ut-LMS will contribute significantly to the development of preventive and therapeutic treatments. Cytoplasmic proteins are mostly degraded by a protease complex referred to as the 20S proteasome, which has many substrates that consist of twenty-eight 20 to 30 kDa subunits [8, 9]. Proteasomal degradation is essential for many cellular processes, including the cell cycle, regulation of gene expression and immunological function [10]. A previous study reported that an interferon (IFN)-γ treatment induced the expression of large numbers of responsive genes, the β-ring subunits of proteasomes, i.e., low-molecular mass polypeptide (LMP)2/β1i, LMP7/β5i and LMP10/multicatalytic endopeptidase complex-like (MECL)-1/β2i [11]. Ut-LMS was detected in female LMP2/β1ideficient mice at 6 months or older, and its incidence at 14 months was approximately 40% [12]. Histopathological studies of LMP2/ β1i-lacking uterine tumors have revealed the characteristic abnormalities of Ut-LMS [12]. The non-standard subtypes of uterine mesenchymal tumors such as the epithelioid and myxoid types have been classified in a Manuscript accepted for publication May 15, 2014


— Wireless Sensor Network (WSN) includes large quantities of sensing node used in various situations to collect data. WSN considers applications to collect data from remote locations, for example in environment surveillance, military, transport protection, etc. An energy efficient routing protocol is essential to handle the discharged electricity of the system and to minimize traffic and upstairs during data broadcast phases to fulfill the sensing, communication and processing tasks of the WSN. The biggest problem in the WSN is that energy resources are small. In this study, an energy-efficient routing protocol improves energy efficiency with the life span of sensor nodes by using optimization


Minneapolis?The potential for better flaps, improved outcomes, and happier patients are the factors that motivated the surgeons at Minnesota Eye Consultants to join the ranks of others who are performing all-laser LASIK using the femtosecond laser microkeratome (IntraLase) for flap creation, said Richard L. Lindstrom, MD.


Originally published in the Bank of Canada Review, these articles are valuable for anyone interested in the history, evolution and rationale of central banks, and the Bank of Canada in particular. Articles are in English and French.


Objective To explore the relative problems about emergency treatment and nursing strategy for vaginal injury.Methods Emergency treatment should be quickly,0.1% adrenalin hydrochloride gauze was used to oppress the lacerative position,aseptic gauze was used to tamp in order to further compression hemostasis,or used catgut to suture the lacerated vagina.For the blood loss was more,we established the venous transfusion quickly,observed vital signs and vaginal bleeding situation,kept perineum cleanly and dry,prevented infection,strengthened psychological nursing and health guidance.Results 12 cases were recovered triumphantly with no wound infection and delayed healing,the mean time was 3 days.One case with vaginal laceration was once again 1 months later during coitus.Conclusion The most causes of vaginal injury are the first brutal sex,wrong posture,overexcitation,ect.Suturing the wound in time,sufficient antibiotic therapy,correct and timely nursing strategy,strengthening health guidance are key to success therapy and avoid the emergence of vaginal injury again.


While digital humanities has emerged as a cutting-edge research trend in the humanities over the past two decades, its application in literary research is still scarce. At present, the field of digital humanities for literary studies is largely focused on theoretical development, critical reflections, and infrastructure building. This article aims to explore the potential of digital humanities in advancing literary research through critical practices and elucidates the distinctive advantages of employing digital humanities methodologies in the study of literature. In this article, a dozen of children's editions of Robinson Crusoe from different historical periods are used as the corpus, and methods such as word cloud, keyword extraction, and sentiment analysis using Python are used to examine the adaptation of Defoe's original novel in children's editions and to uncover a positive inclination throughout the diachronic evolution of children's literature adaptations. It has also revealed some patterns within the intricate details of the different children's editions. In doing so, the article demonstrates the unique advantages of digital humanities in literary studies and proposes new ways of applying digital humanities to literary criticism.


The invention provides a high polymer chemistry coal and rock mass reinforcer for coal mines and solves the problems of the existing polyurethane reinforcing material, such as high price, inflammable and toxic properties, poor performance stability and the like. The high polymer chemistry coal and rock mass reinforcer for coal mines provided by the invention comprises components A and B which are the same in volume, wherein the component A consists of polyether polyol, catalyst and fire retardant, and the component B is polyaryl polymethylene isocyanate; the polyether polyol has more than 3 functional groups, hydroxyl value of 450-550 and molecular weight of 300-500; the catalyst is composed of dibutyltin dilaurate and triethylene diamine; and the fire retardant is composed of methyl methylphosphonate, tri(1,3-dichloro-2-propyl) phosphate and sodium silicate. The high polymer chemistry coal and rock mass reinforcer for coal mines provided by the invention belongs to polyurethane grouting agents and silicate modified polyurethane grouting agents, and is an environment-friendly material with resin content of 100% and no volatile organic compounds, and all indexes of the reinforcer completely accord with AQ1089-2011 quality standard of high polymer material for reinforcing coal and rock mass in coal mines.


Purpose: This study was done to propose an improvement in the Nursing Fee Differentiation Policy to alleviate polarization of nursing staffing level among hospitals and to rectify the confusion of legally mandated standards between the Korean Medical Law and National Health Insurance Act. Methods: The policy regulation was reconstructed related to nurse staffing standards and nurse-to-patients ratios. Data on nurse staffing grades were obtained from database of the Health Insurance Review & Assessment Service (HIRA) for the third quarter of 2010 for 44 tertiary hospitals, 274 general hospitals, and 1,262 hospitals. A break-even analysis was used to estimate financial burden of the revised policy improvement proposal. An industrial engineering method was used to calculate Nurse-to-Patients ratios per shift. Results: Twelve tertiary hospitals were downgraded. 74 general hospitals and 102 hospitals were upgraded after application of the regulation. Finances for total hospitalization expenditures changed from -3.55% to +3.14%. Conclusion: The results indicate that the proposed policy would decrease polarization between tertiary hospitals and small hospitals, and would not put a major strain on the finances of the Korean National Health Insurance. Therefore, it is suggested that government stake-holders and many interest groups consider this policy proposal and build a consensus.


Objective To evaluate findings of QT interval dispersion in acute myocardial infarction. Methods Synchrony 12 lead eletricocardiogram was recorded in 87 cases of acute myocardial infarction and 38 normal cases. QT dispersion and heart rate corrected QT dispersion were used for analysis. Results Patients with AMI had significant larger QTd and QTcd than the controls. Conclusions QTd and QTcd had obvious delay in acute myocardial infarction. Delayed QTd and QTcd could forecast Ventricular Fibrillation and ventricular tachycardia.


Be aimed at the roadheader vibration detection and fault diagnosis,the paper adopts the S3C2410 micro-controller,iMEMS accelerometer sensor and MMC card recording filtered vibration signals based on ARM7 embedded detector.The PC is used to read,analyze and process the recorded data on MMC card.


neither the degree of equivalence of the original text and its translation nor the translation adequacy, understood as rendering the functional focus of the original text, can serve as reliable and universal criteria of translation quality assessment. The situation in which the text was translated, the purpose of translation, the choice of translation strategy should also be taken into consideration, so assessment criteria can not be based on text comparison. The necessity to take into consideration all the circumstances accompanying the process of translation makes it impossible to assess translation quality within the framework of modern translatology.


In an investigation of the production of loud speech, it is found that, in comparison with normal speech, these productions are characterized by a substantially lowered jaw position for all vowels. On the basis of these results, we examine whether, for loud speech, speakers maintain tongue constrictions typical for normal vowel production in spite of the lowered jaw position, or if the tongue follows the jaw using constrictions atypical for the particular vowel. Acoustic analyses of the loud tokens show an increase in F1, thus indicating a lowering of the tongue. Tests show, however, that listeners perceive the intended vowel quality, and not that which might be inferred from the loud formant values. The characteristics of the loud speech targets will be discussed in light of the dynamic constraints of the articulatory system and the perceptual constraints set by the listener.


Several tissues produce and release interleukin‐6 (IL‐6) in response to beta2‐adrenergic stimulation with selective agonists (beta2‐agonists). Moreover, exercise stimulates muscle IL‐6 production, but whether beta2‐agonists regulate skeletal muscle production and release of IL‐6 in humans in association with exercise remains to be clarified. Thus, we investigated leg IL‐6 release in response to beta2‐agonist salbutamol in lean young men at rest and in recovery from resistance exercise.


Hard turning has been explored as an alternative to cylindrical grinding used in manufacturing parts made of tool steels. In the present study, the effects of cutting speed, feed rate and Depth of Cut (DOC) on cutting forces, specific cutting force, power and surface roughness in the hard turning are experimentally investigated. Experiments are carried out using mixed ceramic(Al2O3+TiC) cutting tool of corner radius 0.8mm, in turning operations on AISI D3  tool steel,  heat treated to a hardness of 62 HRC. Response Surface Methodology (RSM) based Central Composite Design (CCD) in Design of Experiments (DOE), is adopted in deciding the number of experiments (20) to be performed with various combinations of input parameters. The range of each one of the three parameters is set at three different levels, namely low, medium and high. The validity of the model is checked by Analysis of variance (ANOVA), predicted models are derived from regression analysis. From the results most favorable parameter setting for superior surface finish is acquired at a medium speed of cutting, medium feed and low DOC.


Objective. To identify the risk factors associated with the increasing of the probability of bovine abortion enabling the execution of effective control prog...


Over recent years, distributed energy resources (DER) have been the object of many studies, which recognise and establish their emerging role in the future of power systems. However, the implementation of many scenarios and mechanism are still challenging. This paper provides an overview of a local energy market and explores the approaches in which consumers and prosumers take part in this market. Therefore, the purpose of this paper is to review the benefits of local markets for users. This study assesses the performance of distributed and centralised trading mechanisms, comparing scenarios where the objective of the exchange may be based on individual or social welfare. Simulation results show the advantages of local markets and demonstrate the importance of advancing the understanding of local markets.


AIM To establish suitable metastatic rabbit Vx2 liver tumor model for experimental study, probe into different tumor transplanted methods and analyze the DSA (digital substract angiography) imagining features of the liver tumor. METHODS 60 male New Zealand white rabbits were divided into 3 groups at random, 20 in each group. 5×10 7 Vx2 carcinoma cells were injected via hepatic artery, pecutaneous into liver by syringe needle in the different 2 groups (control groups); the 3rd group (retrofit group) were transplanted tumor tissue mass (about 10 6~10 8 carcinoma cells) into liver. Then we observed: ①the success rate of implanting tumor; ②the volume change of tumor by ultrasonograpy (the growth rate of tumor was calculated); ③the biological features of tumor (histopathology and electronic microscope photographs); ④the DSA imagining features of tumor. RESULTS The success rates of transplanting tumor of 3 groups were 7/20, 10/20, 19/20; the retrofit group was the highest of 3 groups ( P 0.05). The tumor grew as exponential curve. Histopathology and electronic microscope photographs indicated that tumor grew in the liver tissue and infiltrated into the normal liver tissue, and that it had the similar biological features of squamous cell carcinoma transplanted in other sites of rabbits. The DSA imagining of tumor indicated that the carcinoma had liberal blood vessels. CONCLUSION A retrofit metastatic rabbit Vx2 liver carcinoma model has successfully been set up, The success rate of the method by which tumor tissue mass transplanted is obviously higher than the other two methods. This makes it possible to gain a reliable mature large tumor animal model for study.


As a part of building a harmonious society,building a harmonious enterprise should be people-oriented.The article elaborates this point of view from six aspects.Enterprises can remain invincible only if they achieve harmonious development with the society.


We consider two types of particles performing simple random walks on the integers. When two particles of different types collide they are immediately annihilated. All particles of one type are started off to the left of the origin, and all particles of the other type are started off to the right of the origin. We determine the asymptotic rate of annihilations and the fluctuations, around this rate, of the numbers annihilated at large times.


Through study and practice of the multifarious of preventing breaking coal mass spontaneous combustion,the use of spontaneous combustion technique step in stopped full mechanized mining face is expounded,which has made a good result.


The Glaser Safety Slug and the Velex/Velet Exploding Bullet are both designed to fragment on impact with their targets. Recognition of these rounds after firing is possible by the use of roentgenography and wound tract examination, and the characteristic appearances are described and illustrated. Despite the degree of physical disruption of the bullets recovery of the copper jackets will permit useful comparison microscope examination. In the case of the Velex/Velet Exploding Bullet recovery of the percussion cap may also provide useful information.


Objective:To study the characteristics and changes of left ventricular diastolic function in children with congenital heart disease(CHD) of right ventricular volume overload.Methods:Twenty-eight children with CHD and Twenty age-matched healthy children were recruited in this study. Their frequency spectrum of blood flow at mitral orifice and pulmonary veins were observed by color Doppler B-scanner.Results:(1)Compared with the normal control, the ratios of mitral E/A were lower, the peak velocity of pulmonary vein flow during left atrial contraction(ARP) was higher in the patients(P0.05). There was no significant difference in the decelerating time of E peak (EDT), the isovolumic relaxation time (IVRT) and shrink fraction (SF) of pulmonary veins between two groups(P0.05).(2) The normal ratios of E/A were observed on 13 patients, among them 92% (12/13) had an increased ARP value.Conclusions:The left ventricular diastolic dysfunction could be found in the children with congenital heart disease(CHD) of right ventricular volume overload, which was reflected by the E/A ratios and ARP values that obtained from color Doppler ultrasonography,the latter could distinguish the true normal ratios of E/A from the pseudo-normalized.


The present invention relates to a pulse generator and failsafe systems. A power distribution system includes a power supply connected to the power and ground in a plurality of loads and a plurality of pulse generators, each pulse generator is connected to each of the plurality of a load, configured to produce pulses at a predetermined frequency in accordance with said plurality of loads connected to the other of the power supply and ground.


Molecular orbital results obtained by the self‐consistent‐field Xα scattered wave (SCF‐Xα‐SW) method employing overlapping spheres are presented for the ground state and 15 excited states of ozone (O3). The results are compared with those of ab initio calculations which used the Hartree–Fock (HF), the generalized valence bond (GVB), and GVB with configuration interaction (CI) methods. The Xα–SW method yields the correct gound state (1A1) as do the GVB and GVB–CI methods which explicitly include electronic correlation effects. This is in contrast to the HF method, which predicts the ground state to be a 3B2 state. The Xα–SW molecular orbital (MO) results for the lower, dominantly covalent electronic states considered represent a substantial improvement over the HF–MO results and are consistent with the accurate GVB and GVB–CI results. The results are much less satisfactory for the higher states which are more ionic in character.


The aim of this article was to advance risk communication by examining percentile ranks as a non-arbitrary metric for quantifying risk. Although percentile ranks have a simple meaning, their calculation is complicated by ties (i.e., more than one offender having the same score). The strengths and weaknesses of percentile ranks are discussed, as are the options for calculating and presenting them in applied risk communication. As a demonstration, percentile ranks for Canadian sexual offenders were computed for the most popular sexual offender risk assessment tools (Static-99, Static-99R, Static-2002 and Static-2002R). The distribution of Static-99 scores was highly stable in international comparisons of sexual offenders from Canada (1990 to 2005; n = 2,011), Sweden (1993 to 1997; n = 1,278) and California (2008 to 2010; n = 37,600). The major limitation of percentile ranks is that they measure the "unusualness" of scores in a particular reference group, and may not correspond to other indicators of relative or absolute risk. Consequently, we recommend that evaluators presenting percentile ranks should consistently provide recidivism base rate information so that decision makers do not confuse the rarity of a score with estimates of absolute recidivism risk.


Continuous trading in Taiwan has received increased research interest in recent years. High-frequency trading is of particular interest. But, obtaining a high rate of return poses a lot of challenges. Many of these challenges can be overcome by algorithmic means. Genetic algorithms are an interesting class of algorithms for this kind of problem. Also, there is a growing body of literature that recognizes their importance. In this article we combined a genetic algorithm with a high-frequency trading perspective to consider bandwidth indicator application profitability. We used a simple genetic algorithm and develop an analytical model that examines the impact of different indicators on investment performance. We considered the following indicators: turnover rate, short-sale/margin ratio, bandwidth index and bid-ask ratio. Using these indicators, we select the highest-reward combination of stocks and the most appropriate trading frequency. Furthermore, we train and test the profit and loss performance of each stock group. Data for this study come from the Taiwan Stock Exchange Corporation (TWSE). We found the return rate of the bandwidth index is significantly better than other indicators. Five-minute intervals delivered the best trading results. Additionally, the findings show that the volatility of the bandwidth indicator has a high impact on the volatility of the return rate in high-frequency trading.


Atoms in solids are in constant random motion. Their kinetic energy is heat. Heat associated with local regions may fluctuate. The size of the fluctuations increases with decreasing size of the region. Such fluctuations enable thermally activated processes to occur. At equilibrium interstitials and vacancies undergo random walks in solids, which gives rise to diffusion in crystals and reptation in polymers. The activation energy is the free energy barrier these defects have to overcome to jump between sites. Diffusion is biased by driving forces resulting from gradients of chemical potential. The mobility relates the drift velocity of defects to the driving force on them. The Einstein relation relates the mobility to the diffusivity. It is an example of the fluctuation-dissipation theorem. Atomic motion enables diffusion and limits mobility. Thermal expansion is also a consequence of atomic motion, resulting from a fundamental asymmetry in all interatomic forces.


An examination of population policies and demographic trends in 19 sub-Saharan countries served by the IPPF African Region was undertaken. Due to the crudeness of the data the initial plan to investigate the relationship between demographic trends and government policies could not be followed through. Descriptive findings in regard to birth and deathrate changes observed between 1965-1970 and 1970-1975 were 1) in 11 of the countries birth rates increased and the increase was greatest in Ethiopia; 2) in 5 of the countries the birth rate declined and the greatest declne was observed in Mauritius and; 3) in 10 countries the death rate declined. The 18 countries were grouped into 3 categories in reference to their national population and family planning policies. The countries which had an official policy aimed at reducing population growth and which supported family planning efforts as a way of implementing this policy were Botswana Ghana Kenya and Mauritius. Countries which supported family planning as a human right but which did not have an anti-natalist policy were Dahomey Gambia Lesotho Liberia Mali Nigeria Tanzania Togo Uganda Zaire and Zambia. Countries which neither supported family planning nor had a government policy aimed at reducing population growth were Ethiopia and the Malagasy Republic. Although some family planning is allow in all countries even where it is not the official policy the degree to which family planning is practiced in these 18 countries is not very extensive. The lack of contraceptive practice is frequently attributed to high infant and child mortality; couples produce many children so that at least some will survive to adulthood. At the present time we do not have sufficient verification that high infant and child mortality increases fertility. The observed relationship between high fertility and high infant and child mortality may be due to data collection and analysis deficiencies or to some other factor which increases both variables. Perhaps increased fertility is due to shortened amenorrhea which occurs when an infant dies. The relationship may function in the opposite direction; high fertility might contribute to high mortality. Included is a table showing crude birth and death rates and other demographic characteristics for most of the 18 countries for 1965-1970 and for 1970-1975.


We examine in this paper the issue of how institutions are maintained and the role of agency in this process. We investigate more specifically the efforts of actors to maintain the institutional order through discourse. We approach this issue through an in-depth and longitudinal study of actors' efforts to maintain institutions in the French Music Industry from 2004 to today. Our study focuses on the discursive work of some actors in fixing meaning about artists and then maintaining institutions. To do this, we resort to a discourse analysis and more particularly to a lexicometric study. We contribute to the study of institutional maintenance in two ways. First, we argue that maintaining institutions is the outcome of agency and not an automatic or a mechanical mimetic process. Secondly, we demonstrate the reproduction of institutions through discourse.


Objective To investigate the difference in clinical efficacy of suspended moxibustion with or without deqi(arrival of qi)in the treatment of knee osteoarthritis,and to provide a scientific basis for clinical application of moxibustion according to different acupoints.Methods Sixty patients with knee osteoarthritis(swelling type)were included,and according to whether deqi occurred at Neixiyan and Waixiyan of the affected side(whether the sense of warmth penetrates the knee joint cavity),these patients were divided into deqi group with 34 cases and non-deqi group with 26 cases.The patients in both groups received moxibustion(40min)once daily for 30 days.The clinical outcome was evaluated immediately and at three months after the treatment.Results Immediately and at three months after the treatment,both groups had significantly reduced joint circumference and total score for clinical symptoms(P0.05);the deqi group had significantly lower joint circumference and total score for clinical symptoms than the non-deqi group(P0.05);the clinical efficacy in deqi group was superior to that in non-deqi group(P0.05).Conclusion As for the treatment of knee osteoarthritis(swelling type),suspended moxibustion can effectively improve the clinical symptoms.The immediate and long-term clinical outcomes of patients with deqi are significantly better than those of patients without deqi.


by a twin vane system. During excitation, the jet was found to spread significantly and entrain mass much more than its steady counterpart. Time averaged static pressure measured in the flow field with a disc probe exhibited prominent well defined suction regions different from that of a steady jet. Plane Jet, Static Pressure, Entrainment, Excited Jet Key Words nAo{¥n{ ¥¼fTv« R±aeo½ps


OBJECTIVE
To determine whether p16 gene is involved in the genesis of primary hepatocellular carcinoma (HCC).

METHODS
Twenty-five HCC tumor samples with corresponding non-tumor liver tissue specimens were examined for p16 gene alterations. The identification of deletion of exon 1 and exon 2 in p16 gene was performed using comparative multiplex polymerase chain reaction (PCR) analysis. The point mutation of exon 2 in p16 gene was investigated by single strand conformational polymorphism (SSCP) analysis, and the status of p16 gene methylation was screened using a PCR based methylation analysis. 35 parafin-embedded specimens of HCC with corresponding non-tumor liver tissues, including the 25 cases described above for screening p16 gene alterations, were investigated for p16 protein expression using immunohistochemical analysis.

RESULTS
Among 25 cases, 2 homozygous deletions and 1 hemizygous deletion were found in HCC samples. No point mutation was identified in the remaining 22 tumor samples without p16 gene deletions. Hypermethylation was detected in 24% (6/25) of tumor samples. However, the corresponding non-tumor liver tissue specimens were always unmethylated at the p16 locus. Loss of p16 protein expression occurred in 16 of 35 (45.7%) tumor samples, and all the non-tumor liver tissue specimens showed positive p16 staining. For the 25 cases examined for p16 gene alterations, the loss of p16 protein expression was observed in all tumors with p16 gene alterations and also in 3 tumors without p16 gene alterations.

CONCLUSION
Inactivation of the p16 gene may play an important role in the genesis of primary hepatocellular carcinoma.


This paper analyzes the role of microfinance in poverty alleviation and improving the living standard of poor households. A survey of 400 active clients of the Khushhali Bank (a Microfinance Bank) in Dera Ghazi Khan and Layyah districts of the Punjab (Pakistan) has been undertaken for this purpose. Statistical and econometric techniques are used to explore the impact of the microfinance. It is found that microfinance credit positively affects income generation and consumption level of poor; and the impact on productive activities is higher than the consumption.


The problems that became the basis of this study is the decline in the overall number of subscribers of Graha Candi Golf from 548 in 2015, January to 515 in August 2015. Customers of the golf course Graha Candi Golf is a customer who is usually always come back to play (returning customers). So with this decline, it can be said there are problems decrease attachment to the customer (customer retention) on the golf course Graha Candi Golf. The purpose of this study was to analyze the effect of customer relationship marketing, service quality and corporate image on customer retention and customer satisfaction as an intervening variable. The population of this research is all customer golf course Graha Candi Golf Semarang. The sampling technique was by purposive sampling. The samples used were 117 subscribers golf course Graha Candi Golf Semarang. The analysis method used is quantitative analysis, including descriptive statistical analysis, path analysis, and Sobel Test. Based on the results of testing customer relationship marketing, Service quality and corporate image positive effect on customer satisfaction and customer retention. Customer satisfaction has a positive influence on customer retention. Customer satisfaction is able to mediate the effect of customer relationship marketing, service quality and corporate image on customer retention Key words: customer relationship marketing, service quality, corporate image, customer satisfaction, customer retention.


Data science and artificial intelligence have passed the stage of innovative trends. The applications in practice increase with every year with enterprises of all industry sectors creating new solutions utilising their data. However, there is much to learn for the enterprises, especially for those new to the implementation of information technology and data-based projects. Data science process models can assist in structuring such projects by giving ideal-typical project structures and assist with the provision of explanations, best practices, and concrete tools. One aspect which is rarely covered by data science process models is the utilisation of the results beyond their technical integration. This includes the risk of failing in operation due to missed requirements regarding affected employees or organisational aspects of the enterprises, especially their business processes. This paper provides an overview of relevant aspects for the integration of new data-based solutions into practice, i. e. the socio-technical system environment of the enterprise. Bridges to different project phases and results are shown to derive measures for integration. In addition, common tools for handling the arising challenges and tasks are listed and briefly discussed.


It's not uncommon to hear both lay persons and professionals matter-of-factly refer to the "starvation response" (also called metabolic adaptation) and "setpoint theory" as if they were accepted facts. The supposition of these theories is that the body reacts to reduced energy intake, or weight loss, by lowering its basal metabolic rate in an attempt to maintain the current weight or return to a higher weight. If this were the case the data would show a suppressed resting metabolic rate (RMR) per kilogram of fat free mass (FFM) after weight loss.


Specific trials on adult Burkitt lymphoma (BL) and 'unclassifiable' lymphomas with features intermediate between BL and diffuse large B‐cell lymphoma (BL/DLBCL) are advocated which include substantial numbers of older patients, to improve treatment feasibility, while countering risks of systemic and central nervous system (CNS) recurrences. We prospectively evaluated a modified CODOX‐M/IVAC (CODOX‐M: cyclophosphamide, vincristine, doxorubicin, high‐dose methotrexate; IVAC: ifosfamide, etoposide and high‐dose cytarabine) regimen by the addition of rituximab (R) and liposome‐encapsulated cytarabine (D) to increase antitumour activity and halve the number of intrathecal treatments. Thirty adults (40% >60 years) with BL (n = 15) and BL/DLBCL (n = 15) were accrued. Primary endpoints were progression‐free survival (PFS), CNS recurrence, and liposomal cytarabine‐associated toxicity. Eighty percent of patients received the whole treatment programme, the remaining cases received at least three full courses. Application of the RD‐CODOX‐M/IVAC regimen resulted in remarkable 4‐year PFS (78%) and complete remission (CR) rates (93%). However, PFS was significantly lower in patients older than 60 years as compared to younger ones (49%vs 93%, P = 0·03; median, 36 months), despite high actual dose‐intensity, CR rate and tolerability. Reduced‐intensity intratechal prophylaxis through liposomal cytarabine was effective because the CNS failure rate was low (3·4%) and without severe neurological toxicities. The RD‐CODOX‐M/IVAC strategy is feasible and highly effective, but improving outcomes in elderly patients remains a priority.


This article presents a clinical vignette in which the therapist uses her awareness, as well as the counter-transference and projective identification processes operating in the therapeutic relationship as a mirror or as a barometer indicating something in the client's experience. It is not a metaphor. The author proposes the hypothesis that the neurons of the intestine and the heart, similary to brain neurons, have mirror properties which can reflect somatosensory affective states of the client.


Intramural pregnancy implanting in the previous cesarean section scar is one of the rarest form of an ectopic pregnancy and probably the most dangerous form because of its risk of rupture and hemorrhage. Pathologically, the location of the gestational sac is completely isolated from the uterine cavity and entirely surrounded by myometrium without any contact of endometrium. For young patients who wish to maintain their fertility, an earlier diagnosis and more conservative treatment are highly desirable. We have recently experienced a case of intramural pregnancy implanting in the scar of cesarean section, treated completely with systemic methotrexate injection. So, we report this case with a brief review of the literature.