The city is the engine of wealth growth and accumulation and urbanization is an effective approach to extend public service infrastructure,modern civilization to the countryside,which further promotes the development of the economy.Based on an analysis of actual situation of urbanization development in Hunan,this paper constructs a comprehensive evaluation index system of urbanization construction including 7 first-level indexes and 48 second-level indexes.It carries on the accurate evaluation of construction level and the development degree,in order to promote a new stage of social economy development.


By using the traditional equivalent enthalpy drop method(EEDM) and EEDM related to the piping thermal efficiency respectively,the subcritical units-N600-16.7/538/538 type turbine and SG-2008/17.5-M901 type boiler are chosen to do the research.Through qualitative analysis and quantitative calculation,the piping thermal efficiency′s effect which is caused by de-superheating water and re-heater de-superheating water,is gained and analyzed.Finally constructive suggestions are presented in this paper for power plant that in order to save energy,the effect of de-superheating spraying system on the piping thermal efficiency should be fully considered and thus the variation of thermal efficiency for the thermal economic benefits to the whole plant is inevitably important.


The main harmful disease of white and narrow-leafed lupin is anthracnose. High effective fungicides should to be used to protect its crops. Under field conditions the fungicide Zan-tara (1.5 l/ha) showed the high productivity (91.3%) against this disease. The fungicide is effective against fusaria, sclerotinia and botrytis too. Its use allows protect crops of culti-vated lupin species against diseases' complex and significantly decrease yield losses.


T cell activation induces a metabolic switch generating energy required for proliferation, survival, and fueling their functions. Thus, it is essential to monitor metabolism associated to subcellular functional and structural changes. We used non-invasive label-free two-photon fluorescence lifetime microscopy (2P-FLIM) to map the spatial and temporal dynamics of the metabolic NADH co-enzyme during T lymphocyte activation. 2P-FLIM measurements of the protein-bound and free NADH ratios provides a readout of the redox state (NAD+/ NADH) of the cells, and thus of their OXPHOS and glycolysis rates. Using this method, we followed the dynamics of fraction of bound NADH (fb NADH) in live single cells. Comparing fb NADH between resting and activated T cells, we show that T cell activation induces a rapid switch toward glycolysis. The switch takes only 10 minutes and remains stable for at least one hour. Three-dimensional (3D) analysis revealed that the intracellular distribution of fb NADH is symmetrically distributed in resting cells, whereas increases at the contact zone in activated cells. Finally, we show that fb NADH negatively correlates with spreading of activated T cells, suggesting a link between actin remodeling and metabolic changes. This study shows that 2P-FLIM measurement of fb NADH is well suited to follow a fast metabolic switch in 3D, in single T lymphocytes with subcellular resolution.


We study a boundary value problem consisting of a second-order q-difference equation together with Dirichlet boundary conditions. Separation of variables leads us to an eigenvalue problem for a second-order Euler q-difference equation. We determine the exact number of eigenvalues.


Abstract  The use of marginal donors is well accepted by most centers for emergency situations, but there is debate on their use for patients on regular waiting lists. We report our experience of the l‐year survival for patients on waiting lists (n= 147, 1‐year survival = 32 %), patients transplanted from good donors (n= 60, l‐year survival = 84 %), and patients transplanted from marginal donors (n = 15, l‐year survival = 56 %). We concluded that liver transplantation from marginal donors (a) is a safe procedure (b) has a 1 ‐year survival that is significantly better than that on a waiting list (c) is ethically justified especially in countries with donor shortages, and (d) may allow transplantation of "special" high risk and poor long‐term outcome patients.


To the Editor:

The interpretation of cardiac troponin concentrations at presentation and their dynamics over time is a key aspect in the diagnostic workup of acute myocardial infarction in the absence of characteristic electrocardiogram abnormalities. The present biological variation study sought to examine and compare the hour-to-hour biological variation in cardiac troponin I (cTnI) over 24 h in individuals with and without chronic kidney disease (CKD).1 This study was carried out according to the principles of the Declaration of Helsinki and approved by the Institutional Review Board and Ethics Committee of Maastricht University Medical Center (clinicaltrials.gov: NCT02091427 and NCT02210897). All participants provided written informed consent.

From 8:30 AM until 9:30 AM the next day, 20 individuals with clinically stable CKD stage 3 or higher (estimated glomerular filtration rate (eGFR) <59 mL · min−1 · 1.73 m−2) and 20 individuals without CKD were restricted to the laboratory environment. All individuals were of Caucasian ethnicity. Every hour during 24 h, …


Abstract : Gas bubbles have been reported to routinely accumulate in cavities during anodic or cathodic polarization in several merals and alloys (Fe, Ni, Cu, Al, stainless steel). These in-place gas bubbles have been found to sharply increase the gradients of potential and ionic concentration within the cavities. A limiting electrode potential, E sub (LIM), in the cavity has been observed, consistant with theoretical considerations which predict its existence. Mathematical modeling has been reasonably successful, especially in the case of cathodic polarization where the calculation shows that the potential and concentration gradients are strong functions of the sharpness of the crack, the ohmic voltage increasing as the crack opening decreases, in agreement with earlier calculations of current distribution in slots by Wagner. By analogy, a similar result in expected for anodic polarization. The shift of the potential with increasing distance into a cavity is always in the direction of a decrease in anodic or cathodic polarization, is typically very large approaching the E sub (LIM) value of the system, is largely independent of the cathodic or anodic polarization, is typically very large approaching the E sub (LIM) value of the system, is largely independent of the cathodic or anodic polarization applied to the external surface and often places that base of the cavity in a potential regime of other reactions, e.g., anodic metal dissolution at the crack tip while the sample's outer surface is under effective cathodic protection.


The ESP was one of the largest and most diverse conferences I have ever joined. More than 400 speakers presented their research from all fields of photobiology. This broad coverage of topics created an interdisciplinary atmosphere and offered new perspectives. Therefore it is impossible to summarize all the scientific presentations and I rather will try to highlight a few presentations and describe my personal experiences.


At present, permanent pacemaker implantation is one of the most common therapeutic or prophylactic strategies in the management of patients with cardiac problems. The present study was undertaken to evaluate the clinicalprofile and outcomes of patients undergoing pacemaker implantation.Total 30 patients, who received permanent pacemaker for bradyarrhythmias from 1st August 2018 to 30th May 2019, were included in the study. A detailed analysis inclusive of history taking and clinical examination followed by biochemical work up (renal function test, thyroid function test, random blood sugar) and cardiac work upwere done for each patient. The mean age of patients at implant was 60 years with male predominant. The most common presenting symptoms were syncope (in 66% of patients) followed by lightheadedness (63%), Fatigue (56%), palpitation (56%), and dyspnea (53%).Hypertension (63%) was the most common associated co-morbidity. Complete heart block (70%) was commonest indication of pacing followed by sick sinus syndrome (SSS) (23%) and trifascicular block (7%).The complications observed were pneumothorax and pacemaker implant site wound exudation in one patient each.Complete heart block (CHB) was the major indications of pacemaker implantation in present study and advanced age and male gender were associated with higher implantation rate with minimal complications. The pacemaker implantation is a lifesaving procedure and improves quality of life dramatically.


In this study, high-performance In2Se3/Silicon-on-Insulator (SOI) heterojunction field-effect transistor photodetector is fabricated. The In2Se3/Si heterostructure phototransistor exhibits dual-band detection with a maximum responsivity of 12 A/W and 41 A/W for illumination of 405 nm and 800 nm wavelengths, respectively. This phototransistor has shown a lower noise-equivalent power of 6.8 fW.Hz<inline-formula> <tex-math notation="LaTeX">$^{-1/2}$ </tex-math></inline-formula> and higher detectivity of <inline-formula> <tex-math notation="LaTeX">$2.9\times 10^{13}$ </tex-math></inline-formula> cm.Hz<inline-formula> <tex-math notation="LaTeX">$^{1/2}\text{W}^{-1}$ </tex-math></inline-formula>. Flicker noise dominates the In2Se3/SOI phototransistor with a corner frequency of 3 Hz. The device's enhanced performance is due to the improved synergistic effect with efficient electron-hole dissociation in the heterojunction. This heterostructure based photodetector can be of great interest for dual-band (Ultra-violet and visible) detection in imaging, optical communication and healthcare applications.


An analysis is made of the influence of transit effects on the profile of a two-absorption line of a gas interacting with a standing wave field. It is shown that in the case of a confined light beam the resonance width is governed by the transit times of atoms across the beam. When two light beams separated by a large distance are present, there is an additional resonance line of width which is the reciprocal of the transit time between the beams. This resonance is analyzed allowing for the relaxation of atomic levels.


Malaysian students come from various ethnicities and cultural communities since Malaysia is known as a multiracial and multicultural country. Therefore, issues related to the portrayal of local cultural aspects in KBSM English Language materials used in some Malaysian schools have captured the attention of researchers. This study employs a set of checklist which has been used as a guideline to analyze the cultural aspects in a curriculum in order to examine English Language Form 1 to Form 5 textbooks used in schools in Johor Bahru. The findings show that there was insifficient incorporation of cultural aspects into the English materials. Many of the available cultural elements were presented at a superficial level and not discussed within the holistic cultural experience. The findings suggest that the absence and the lack of certain cultural aspects in the materials may be due to the fact some cultural topics are avoided fearing sensitivity, and that they may be implicitly portrayed through, for example, value integration, moral and educational emphasis. This study recommends that language learning materials must be able to present the language learners' own culture and all the cultures that suround them and the materials must be useful and effective both as English learning materials as well as a tool for promoting cultural knowledge and understanding among Malaysian students.


Background: One of the main subjects of training and assessing medical science students is to promote their knowledge, attitude, and skills as is too accurately and correctly assess them. Scientific evidence shows that theoretical assessment of students through written and oral exams cannot suffice to determine their skill performance and competence, making it necessary to find a new method. Therefore, we decided to examine internship course in anesthesia through an objective structured field examination (OSFE). The goal was to test clinical skill performance and competence of anesthesia students based on the same criteria, namely, by an instructor's observation of the student's skills and assessment based on pre-designed checklists. Materials and methods: This study enrolled 25 anesthesia students who had completed internship course in the form of a final exam at the Nikookari Teaching Hospital in Tabriz Iran based on using OSFE method. In this study, data collection tool was skill assessment checklists for skills including identifying the patient and controlling their files, preparing the required equipment for anesthesia, intravenous cannulation, maintenance of anesthesia, endotracheal extubation, recovery room care and patient's discharge from recovery room. By scoring each procedure, the results of the checklists were evaluated and analyzed through qualitative statistical methods. Results: In this study, the mean of the final score was 16.27±1.41, and that of the following skills was 18.46±1.3 for identifying the patient and controlling their files, 16.67±1.4, preparing the equipment for anesthesia, 17.34±1.8, endotracheal extubation, 16.00±2, maintenance of anesthesia, 17.72±1.2, recovery room care, and 14.00±1.1 for patient's discharge from recovery room. The university examiner for training program approved the examination as excellent. Moreover, the students were content with this assessment method and assess it as excellent with the mean of 72.43±10.18. Conclusion: This examination improved assessment methods of skill performance and competence of anesthesia students by means of the same criteria. We suggest that the above-mentioned method, which is a revised version of OSFE be implemented in other fields of medical sciences. [Afhami MR. Designing and implementing the test Objective Structured Field Examination (OSFE) for improving assessment of internship course of anesthesia students. Life Sci J 2013;10(9s):173-176] (ISSN:10978135). http://www.lifesciencesite.com. 21


Purpose. The importance of physical activity in various aspects of health including cognitive health estimated by students' academic performance is being emphasized in many publications. Comparatively, the relations between somatic as well as motor components of physical ability and the academic performance, are examined more seldom. For this reason, the aim of this paper is to search for relations between selected components of physical and reasoning ability, as well as to establish whether any intersexual differences may be observed. Basic procedures. In the study, the measurements of basic traits of physical development and the results of selected motor tests performed by 12-year-old students (53 girls, 45 boys) were used. Reasoning ability was estimated on the basis of results obtained by students in the final exam of primary school. To estimate the relations between the considered variables, a linear correlation was employed, and in further proceedings, the best subsets regression procedure. Main findings. The occurrence of intersexual differences in the area of relations between the somatic and motor components of physical ability, and reasoning ability was observed. These interrelations are especially evident in multiple correlation. Conclusions. A higher level of somatic and motor development is conducive to better results of students' reasoning ability. The somatic and motor components of physical ability, presented as a set of explanatory variables, are dependent on the subject's sex in approximately 17–37%, and are the source of the variability of the results of reasoning ability. NR 64 2013 AN TRO PO MO TO RY KA


This thesis examined the delivery of exercise physiology services from the Queensland University of Technology Health Clinics. Evaluation constituted three conceptually linked studies that investigated client health outcomes and experience of health care, as well as the learning experience of students delivering a model of rehabilitative care in post-traumatic stress disorder and cardiac rehabilitation. Value was demonstrated through safe and effective client health outcomes, both physically and psychologically. Client experience of health care and student experience of learning revealed a supportive culture of health and educational development that will inform the future design of health care and student education environments.


This paper defines the data concerning the identity of sarapion and of his brother hippalos. We depart from the actual confusion in TM People of this sarapion and a contemporary official with the same name. We collect the prosopographical information about the two brothers, sarapion and hippalos, listing all the papyrological evidence; we separate the evidence related to the brother of hippalos from those concerning the namesake official. Finally, we add the texts not present in TM People yet


Corruption is a major global financial problem with billions of dollars rendered lost or unaccountable annually. Corruption through contract fraud is often conducted by withholding and/or altering financial information. When such scandals are investigated by authorities, financial and legal documents are usually altered to conceal the paper trail. Smart contracts have emerged in recent years and appear promising for applications such as legal contracts where transparency is critical and of public interest. Transparency and auditability are inherent because smart contracts execute operations on the blockchain, a distributed public ledger. In this paper, we propose the Minimum Hybrid Contract (MHC), with the aim of introducing 1) auditability, 2) transparency, and 3) immutability to the contract's financial transactions. The MHC comprises an online smart contract and an offline traditional legal contract. where the two are immutably linked. Secure peer-to-peer financial transactions, transparency, and cost accounting are automated by the smart contract, and legal issues or disputes are carried out by civil courts. The reliance on established legal processes facilitates an appropriate adoption of smart contracts in traditional contracts.


The author points out that Logistics Industry is the key point for the fully implementation of building a new socialist countryside.Based on some statistics data,the author puts forward a mathematic model to measure the performance of rural governance measurement,and form a conclusion that logistics industry is bottleneck for the development of Shanghai rural areas.To break through this bottleneck,we should,first,form a logistic development mode consistent with regional population and the mode of resource flow;second,improve the arrangement and plan of inner-region transportation net;third,intensively take advantage of land;forth,establish a multi-element logistic network organization and so on.


Naomi Wallace's political theatre has been an ongoing pursuit of social change, combining socio-political critique and inquiry into history. In her 1994 play In the Heart of America, Wallace delves into the interlocking network of violence, war, homophobia, and racism. Tracing the identity quest of Remzi, an Palestinian-American soldier who is beaten to death by fellow soldiers during the Gulf War of the early 1990s, the play presents scenes of violence in which racist and homophobic hate crimes victimize racial and sexual minorities. These minorities are, in the words of Boxler who speaks for the national ideology of freedom and American foreign policy, the "enemies" of the nation. They are discursively constituted for the ideological purpose of justifying imperialist wars overseas. In order to problematize their disidentificatory relations with American national ideology, Wallace's play focuses on representing Medina's notion of "identity trouble" these minority characters experience. Dramatizing Medina's familial notion of identity that all identity categories are intrinsically heterogeneous and unstable, Wallace presents characters of hyphenated and queer identities fighting in Iraq who feel that they don't quite belong to America, who feel ill at ease with American national ideology. Remzi witnesses violence in "the heart of America" and then in the U.S. military camp, and accordingly moves from identification to disidentification with America, finally reclaiming his Arab roots as a Palestinian. Craver similarly stands "uneasy" under the master signifer of America, but he maintains his disidentificatory relation with the nation. He resists the national ideology by citing and appropriating its language to re-signify its meaning and reconstitute his identity.


Abstract. After a brief survey of the underlying fundamentals for Inflation Targeting, we test the performance for Latin American countries that are currently using this monetary policy regime. Specifically, we will analyze the cases of Brazil, Chile, Colombia, Peru and Uruguay. For this group we estimate monetary policy rules, and discuss their coherence to the benchmark framework. We compare, as well, their performance in dealing with targeting inflation. For a more comprehensive panel of inflation targeters we test causality from monetary policy rules disalignments to policy objectives. We find, with some few exceptions, that Latin American countries set monetary policy as predicted by open economy's optimal rule a la Parrado & Velazco (2002). We also find that monetary policy rules disalignments lead to deviations of inflation from its target.


The thermal analysis of high speed machine is necessary made to check of serviceability. The temperatures of electric machine individual parts influence other aspects of electric machine design. This paper deals with modeling of thermal phenomena of high seed asynchronous machine. The main requirement for this model is easy integration into electromagnetic model. The Computational fluid dynamics (CFD) analysis can be used to determine some boundary condition of thermal model that aren't commonly known for high speed machine.


Major depressive disorder (MDD) is a debilitating human health status characterized by mood swings and high suicidal attempts. Several studies have reported the role of neuroinflammation in MMD, yet the efficacy of natural drug substances on neuroinflammation-associated depression needs to be further investigated. The present study demonstrated the neuroprotective effects of Acetyl-L- carnitine (ALC) alone or in combination with caffeic acid phenethyl ester (CAPE) on lipopolysaccharide (LPS) induced neuro-inflammation, depression, and anxiety-like behavior.Male Sprague Dawley (SD) rats were used to explore the relative effects of ALC and the mechanistic interplay of the peroxisome proliferator-activated receptors (PPARγ) in depression. Lipopolysaccharide (LPS) was administered to induce depression and anxiety-like symptoms such as a decreased grooming tendency, diminished locomotive activity, and increased immobility period.We found marked neuronal alterations in the cortex and hippocampus of LPS intoxicated animals associated with higher inflammatory cytokines expression cyclooxygenase (COX2), tumor necrotic factor-alpha (TNF-α). These detrimental effects exacerbate oxidative stress as documented by a compromised antioxidant system due to high lipid peroxidase (LPO). ALC significantly reverted these changes by positively modulating the PPARγ dependent downstream antioxidant and anti-inflammatory pathways such as NOD and pyrin domain-containing protein 3 (NLRP3) linked nuclear factor kappa B (NF-κB) phosphorylation. Moreover, co-administering NF-κB inhibitor caffeic acid phenethyl ester (CAPE) with ALC also increased PPARγ expression significantly and decreased NF-ᴋB and NLRP3 inflammasome.These findings indicate that ALC could be a possible depression supplement. The effects are partly mediated by inhibiting neuroinflammation and NLRP3 inflammasome coupled to PPARγ upregulations.


Previous case-control studies reported more than 15 years ago found positive associations between use of an intrauterine device (IUD) and tubal infertility, and in one of them copper devices in particular were implicated.The present unmatched case-control study, undertaken at three public hospitals in Mexico City, recruited 1895 women in the years 1997-1999: 358 with primary infertility and documented tubal occlusion, 953 with primary infertility but not tubal occlusion, and 584 primigravid control women. A thorough reproductive history was taken, and blood was tested for antibodies to Chlamydia trachomatis. Risk factors were comparable in the women with tubal occlusion and the infertile control women, but compared with those with tubal occlusion, pregnant control women reported more sex partners, had lower rates of past upper genital tract infection, and described fewer symptoms of pelvic inflammatory disease. Positive tests for Chlamydia antibody also were less frequent in this group. Previous use of a copper IUD was not associated with an increased risk of tubal occlusion, regardless of which control group was included in the analysis. When pregnant control women were included, women whose partners used condoms were at half the risk as those using no contraception. Antibody to C. trachomatis in women not using a copper IUD was associated with tubal occlusion (odds ratio, 2.4) when pregnant control women were analyzed. No such effect was noted in women who had used an IUD. These findings indicate that copper IUDs are much safer than previously thought and that these devices may be considered for nulligravid women who are not at risk for sexually transmitted disease. The investigators, in fact, believe that contemporary copper IUDs may be among the most effective and safest reversible contraceptive methods and also one of the least expensive.


In the globalized food markets, certifications of quality and safety standards have become commercial weapons. Assistance in the implementation and the control of these factors in developing countries proves indispensable in order to enable them to have access to world markets. The purpose of this paper is to illustrate such an approach through a project implemented in Vietnam in 2005-2006, supported by the European Union within the framework of the EU-VIETNAM SMALL PROJECTS FACILITY. The project "Improvement of shrimp products' quality exported to Europe through building up capacity of shrimp producers, private sector and local authority in Bac Lieu province" aimed at strengthening the skills of Vietnamese managerial staff and researchers in the study of the sector, the establishment of quality and health standards and the development of sector management policies and measures to achieve the established standards.


This paper discusses the difference between the Visual Studio Tools for Office and traditional VBA based on .NET,and points out the superiority and prospects of Visual Studio Tools for Office.


A review of the literature demonstrated the need for more empirical studies concerning survivors of incest. Eight recent empirical studies were examined with respect to their adherence to a procedural framework based upon the scientific method. It was hypothesized that various specific threats to internal, external, construct and statistical conclusion validity would be present in the studies. The hypothesis was supported. All expected threats to validity (except threats to internal validity) were found in the studies. The results were summarized in table form. A lack of communality was observed across studies. Suggestions were offered for improvements in the problem areas identified.


Abstract An electroanalytical methood, based on derivative chronopotentiometry of the complex of beryllium(II) with 4-[(4-diethylamino-2-hydroxy-phenyl)-azo]-5-hydroxy-naphthalene-2,7-disurphonic acid (Beryllon II) accumulated adsorptively on the surface of a hanging mercury drop electrode, has been developed for determining trace beryllium in food. The dependences of the peak height on the dt/dE vs. E curve on the pre-concentration time, preconcentration potential and the constant reducing current are discussed. In 0.15 mol/1 NHs+0.05 mol/1 NH4Cl, 4×10−7 mol/l Beryllon II, and at a preconcentration potential of -0.30 V (ve. SCE), the limit of detection and linear range are 1 × l0−10 mol/l and 3 × 10−10 -2 × l0−7 mol/l, Iwpectively. The relative standard error of the method is 2.3% for 6 × 10−8 mol/l Be(II). The method WBB applied to samples of food. The electrode procees hae been diecueeed.


The purpose of this study is to establish the key elements of brand equity for international students by exploring existing brand equity theory in its applicability to international higher education (HE). The main objective of this research is to enhance academic understanding of brand equity in the HE sector and explore the implications for management practice. Quantitative data collected via a self-completion survey are used to test a model of brand equity in the context of HE. The empirical setting is Slovenia, which has a mixture of public and private provision and an increasingly competitive environment. The results provide support for the proposed conceptual model, with image-related and awareness-related determinants. The findings of this research provided evidence that the customer-based brand equity model can be applied to the HE context as an element of competitive advantage and used to guide marketing activities for Universities internationally.


The authors of the article suggest the strategy of forming a platform operating model to increase the level of digital maturity of industrial systems in the changing conditions of reality. They have analyzed the current situation on adapting industrial systems to the changing conditions of reality of 2022: the sanctions restrictions and the COVID-19 pandemic crisis. In analogy with the bionics companies concept the authors introduce the term of «bionic industrial systems» as the aggregate of economic entities which form the closed cycle of producing artificial products by machine and combine new technology with human ability of transforming operations on the basis of digital strategizing, develop the experience, customer relationships and more effective performance, increase the pace of innovation significantly. There is a conclusion that bionic industrial systems are characterized by the presence of digital strategies, high level of digital maturity which should be evaluated according to the index of digital acceleration. The authors suggest four strategies allowing transformation of industrial systems into bionic ones and maximize their value on the basis of digital strategizing. The use of platform operating model is considered to be the key distinctive feature of the bionic industrial systems. The article presents the strategy of forming a platform operating model of bionic industrial systems based on the model of digital transformation of the transactions of the Deloitte company. This is the structure describing the digital path on the basis of defining 10 evolution stages taking into account cybersecurity and digital culture. The digital industrial platform ZIIoT by the Russian IT-company «Tsifra» (Digit) has been studied as the best experience, and the authors present practical cases of its implementation in Gasprom, Lukoil, Novolipetsk Metallurgical Plant. The implementation of the strategy of forming a platform operating model in industrial systems is expected to result in reducing costs due to accelerated implementation of digital scenarios, additional income and opportunities of diversification through digital strategizing, etc. The authors introduce the concept of forming a platform operating model to increase the level of digital maturity of industrial systems.


We present a class of numerical methods for the semiconductor Boltzmann Poisson problem in the case of spherical band energies. The methods are based on spherical harmonics expansions in the wave vector and difference discretizations in space–time. The resulting class of approximate solutions dissipate a certain type of entropy.


OBJECTIVE To assess the costs of tuberculosis at household level in Dar es Salaam and to compare them with the provider costs of the national tuberculosis control programme.


Education Muhammadiyah University of Surakarta.
The aims of this research are to describe the equivalence of intention of expressive utterances in action film and its translation, and to describe the equivalence of politeness strategy of expressive utterances in action film and its translation.
The type of this research is descriptive qualitative. The data source of this research is action film and its translation. The methods of analyzing data are observation and documentation. The techniques of analyzing data of this research are describing the equivalence of the intention by referring to the speech act theory and describing the equivalence of the politeness pattern by referring politeness strategy.
Based on the result of the data analysis, the writer findsthe equivalence of the intentions and the equivalence of politeness pattern of expressive utterance in action film and its translation. The equivalece of intention of expressive utterance used in action film and its translation are: praising (22,22%), apologizing (13,89%), feeling of irritated (27, 78%), thanking (6,94%), accusing (4,17%), feeling of frightened (12,5%), feeling of surprised (2,78%) and feelingof pleasure (9,72%). The politeness pattern is divided into three kinds, they are: bald on record (45,83%), positive politeness (41,67%), and off record (12,5%).


In the October number of the School Review' the writer discussed various devices aiming to meet the needs of the slow worker in mathematics. These devices reflected by current practice in institutions offering practice teaching courses are: (i) conferences with teachers and student teachers in hours other than the class period; (2) special supervised classes of study; (3) division of classes into separate sections on the basis of ability; (4) the use of bright students as instructors of the slow students (this device was found to to be in extensive use; a report of an experiment aiming to evaluate this device by testing the effect of classroom communication on the learning process was presented, the objective evidence tending to show that not only was the slow student weakened but the fast worker lost in interest and efficiency); and (5) a definitely organized minimum course of study.


The system and apparatus for identifying the time of the event, such as an edge received by the data signal or the clock signal and generating a time stamp to record is disclosed. A set of strobe pulses can be generated by routing the external clock signal to a delay element to delay value is increased gradually. The data signal or the device under test clock signal may be applied to each input of a set of the latch that is clocked by a strobe pulse. This causes the set of the latch may capture a series of samples of the data signal or the clock signal. The sequence of samples may be encoded as an edge in the clock cycle time. A clock cycle counter may be added to the edge time to produce a time-clamp. Data signal, a clock signal, an edge, the event, timestamp, a strobe, a digital signal, a delay element, a strobe pulse, latch, counter


Our current matrimonial law is revised in 2001,of which the rules about legal couple's property are detailed.However there are still many defects in both the framework and the fundamental composition.Because of its importance to our families,it is necessary to perfect the system.


The utility model discloses an object displacement device which comprises a fixed frame, a jacking power mechanism and a horizontal movement mechanism, wherein the jacking power mechanism is used for jacking an object positioned on a bottom plate of the fixed frame; and the horizontal movement mechanism is used for horizontally moving the object; the jacking end of the jacking power mechanism is connected with a fixed plate and can drive the fixed plate to move; a slide rail is fixed on the fixed plate; and the horizontal movement mechanism comprises a translational power mechanism and an object supporting mechanism which is driven by the translational power mechanism and can slide along the slide rail. The object displacement device has the beneficial effects that the object can be conveniently and quickly displaced, the process of a whole production line realizes semi-automation, the safety is high, the labor production efficiency is improved, the work intensity is reduced, and the production cost is reduced.


Oscillatory spanwise wall motion is known to cause a substantial reduction in streamwise friction drag. This is of particular interest in civil aviation where fuel efficiency of major importance. Given optimum actuation conditions, reductions of almost 50% can be achieved in channel flow at relatively low values of the Reynolds number although the effectiveness declines with increasing Reynolds number.


&NA; The transgenic mouse strains surfactant protein C‐reverse tetracycline transactivator (SP‐C‐rtTA), club cell secretory protein (CCSP)‐rtTA, and tetracycline operator (TetO)‐Cre have been invaluable for spatiotemporally regulating gene deletion in the pulmonary epithelium. In this study, we measured the efficiency and specificity of gene deletion that can be achieved in these mice using the Rosa26‐eYFP reporter. Triple‐transgenic mice (tTg or rtTA/TetO‐Cre/Rosa‐eYFP) were bred and treated with various doxycycline (dox) regimens to induce gene deletion, which was then quantified in various cell populations by flow cytometry. In these crosses, we found that the TetO‐Cre transgene must be transmitted through the female parent to avoid germline gene deletion. With dox exposure during lung development, SP‐C‐tTg mice deleted in ˜65‐75% of alveolar epithelial type II (ATII) cells, but in only ˜45‐50% of the integrin &bgr;4+ population, which consisted of club cells and distal lung progenitor cells. In contrast, CCSP‐tTg mice deleted in ˜50% of ATII cells and ˜80% of integrin &bgr;4+ cells. Upon dox treatment of adults, deletion in ATII cells and integrin &bgr;4+ cells in SP‐C‐tTg mice dropped significantly to ˜20% and ˜6%, respectively, whereas CCSP‐tTg mice deleted in ˜57% of ATII and ˜40% of integrin &bgr;4+ cells. Interestingly, untreated CCSP‐tTg mice also deleted in ˜40% of integrin &bgr;4+ cells, indicating significant leakiness of CCSP‐tTg in &bgr;4+ cells. In all mouse groups, minimal deletion occurred in mouse tracheal epithelial cells or in mesenchymal or hematopoietic cells. These data provide the first quantitative, side‐by‐side comparison of the deletion efficiency for these widely used transgenic mouse strains.


Attitudes towards their work situation are compared for Japanese and Australian managers working in the Australian subsidiaries of Japanese companies. Discriminant analysis is used to establish a "direct" cultural axis, which distinguishes between the two groups' direct perspectives, and a "stereotype" cultural axis, which distinguishes between their stereotypes of the other group's direct perspective. Discrimination rated at 93% is attained on the direct cultural axis, and complete consensus on the stereotype axis. However, it is shown that the direct and stereotype axes are unrelated. The lack of congruence between myth and reality is examined using the item loadings onto the two discriminant axes.


A rectilinear drawing of a graph is one where each edge is drawn as a straight-line segment, and the rectilinear crossing number of a graph is the minimum number of crossings over all rectilinear drawings. We describe, for every integer k ≥ 4, a class of graphs of crossing number k, but unbounded rectilinear crossing number. This is best possible since the rectilinear crossing number is equal to the crossing number whenever the latter is at most 3. Further, if we consider drawings where each edge is drawn as a polygonal line segment with at most one break point, then the resulting crossing number is at most quadratic in the regular crossing number. © 1993 John Wiley & Sons, Inc.


Based on parametric design of open-air coal mining machine,and according to its concrete characteristics,implementation method of parametric design system for open-air coal mining machine is researched.The system workflow is described,and Pro/TOOLKIT,SQL server and so on are determined as development tools of system.This system can reduce design cycle of open-air coal mining machine,and improve design quality.


Photoperiod response (Ppd) genes are very important for adaptation of wheat to different agro-climatic conditions, but also have influence on crop yield. The aim of this study was to compare agronomic traits of 10 Serbian wheat cultivars and 54 NILs of cv. Paragon with single, double and triple doses of Ppd-1 alleles. The results showed that the NILs with introgressed single early Ppd-1 alleles (Set 2), as well as the NILs with introgressed Ppd-1 null alleles, knock-outs and late alleles (Set 4) had significantly longer stems and spikes then Serbian cultivars (Set 1). The lines with introgressed double early Ppd-1 alleles (Set 3) were very similar to the Serbian cultivars. Some promising lines with good potential for breeding programs were identified


Juice is defined in the most general sense as the extractable fluid contents of cells or tissues. Juices, in general, are good sources of vitamins and minerals and other valuable components to human health. Fruit juices are highly perishable commodity and are thermally processed to aid their preservation. However, heat processing particularly under severe conditions may induce several chemical and physical changes that impair the organoleptic properties and may reduce the content or bioavailability of some bioactive compounds.In pasteurization, sterilization and blanching, the use of heat can destroy nutrients such as thermally labile vitamins and also components responsible for product flavor and taste.Non thermal technologies are preservation treatments that are effective at ambient or sub-lethal temperatures, thereby minimizing negative thermal effects on fruit juice nutritional and quality parameters.High pressure processing (HPP) is a non-thermal food preservation technique for microbial and enzyme inactivation with reduced effects on nutritional and quality parameters when compared to thermal treatments.High Pressure Processing can provide safe product with reduced processing time and maintain maximum fresh-like flavor and taste in the product due to the lower processing temperatures. Moreover, it is environment friendly since it requires only electrical energy and no waste by-products generated. Therefore, High Process-treated fruit juices are superior in fruit juice preservation in the areas of microbial inactivation, sensory improvement and shelf-life extension to those of juices preserved in the traditional way by heat treatment.


It is difficult to satisfy practical measurement because of poor noise immunity and low precision of traditional vortex flow meter.Therefore,it is prevailing study tendency in the flux measurement to research and exploit vortex flow meter with high noise immunity.Aiming at the existing problems of the present vortex flow meter,a new embedded vortex flow meter was designed,the hardware configuration and related circuits were given;on the aspects of algorithm of signal processing,the spectrum correction method of the chirp-Z transform was presented to improve the measurement precision through reducing the frequency space of the main lobe region of the spectrum based on FFT without increasing more operations.Meanwhile,in order to verify its validity,the Matlab simulations were carried out.The simulation results show that the method has the advantages of high accuracy,rapid speed and flexibility.


Using block-matrix sweep techniques of numerical modeling the influence of ohmic losses in the waveguide walls have been investigated. The absence of agreement with the second order periodic condition for EM field distribution in the longitudinally-periodic waveguide with lossy walls is shown.


The objective of this paper is to examine the solidification possibilities of selected waste in form of industrial waste sludge, within the paper solidification formulas are designed which are subsequently laboratory tested by compressive strength tests after 28 and 60 days, leachability tests and other tests considering environmental impacts – ecotoxicological tests.


Summary A critical check list of Bulgarian spiders is presented, together with a comprehensive review of published data. Altogether 910 species based on 173 publications are listed, derived from a total of 7,222 records. Many changes in nomenclature have been made as a result of taxonomic revisions and the re-examination of existing collections. The following new synonyms are proposed: Linyphia phrygiana var. pirini Drensky, 1921 = Pityohyphantes phrygianus (C. L. Koch, 1836), Hogna (Tarentula) macedonica Drensky, l929 = Hogna radiata (Latreille, 1817), Prosthesima bitolensis Drensky, 1929 = Zelotes gracilis (Canestrini, 1868), Comaroma ressenensis Drensky, 1929 = Spermophora senoculata (Duges, 1836), and Cyclosa strandjae Drensky, 1915 = Cyclosa conica (Pallas, 1772).


ABSTRACT Waterborne polyurethanes can be formulated into coatings and adhesives, containing little or no co-solvent, that form films at ambient temperature. They exhibit excellent adhesion to many surfaces including glass and polymeric fibers. These environment-friendly polymers are non-toxic, non-flammable, and they do not pollute the air or produce wastewater. In general, the polyurethanes are hydrophobic in nature and insoluble in water. Therefore, in order to disperse them in water, they must be modified by, for example, incorporating ionic groups and/or non-ionic hydrophilic segments into the polymer structure. In this review paper, types of waterborne polyurethanes, synthesis methods, and applications have been studied. GRAPHICAL ABSTRACT


The perfect catalyst: The advances towards the ability to design a catalyst from first principles are explored. Aspects of computational chemistry as well as the kinetics and physical state of the reactive catalyst are discussed.Keywords: Keywords: catalyst design; computational chemistry; heterogeneous catalysis; kinetics; surface chemistry


The thesis focuses on labour market flexibility,
security and complexity. The research is divided into three
chapters: two of the chapters specifically relate to perceived
security, flexibility and job satisfaction, using data from the
longitudinal Swiss Household Panel (SHP), while the last
investigates labour market programs and their impact on a regional
labour market. The first essay analyses perceptions of economic
insecurity in Switzerland, during the business cycle between 2008
and 2011. The analysis contributes to depict perceptions of Swiss
workers; results show that perceptions of job security tend to be
higher among workers with supervisory responsibilities, among
permanent workers and among workers who live in regions that are
not adversely affected by economic conditions. The second essay
focuses on the determinants of perceived job satisfaction, a
summary measure reflecting how workers value various job
characteristics, paying specific attention to the role of perceived
security and temporary contracts. Results indicate that the
duration of the contract may be less important if the worker
perceives that he is not at risk of unemployment: job stability and
perceived security are nonetheless valued in different ways and the
lack of job security is a primary source of job dissatisfaction. No
significant differences emerge on the estimated effect by gender,
while some heterogeneity is evident by age and education. Finally,
the third paper, that follows (ACE) models approach, highlights a
mechanism of the job search in a regional labour market
characterized by a complex environment where firms, worker agents
and policies interact in a systemic way. The model allows to
approximate quite a number of stylized features of the southern
Swiss regional labour market.


history of the Indonesian people, but also helped to reconcile the Dutch and the Indonesian governments at the time. Phacharaphorn Phanomvan in chapter 10 shows the importance of social media and websites that serve as tools to expand local understanding of regional and local history. Social media have helped to make the Plai Bat Avalokitesvara statue and the Prakhon Chai sculptures a regional pride and promoted local heritage in the Northeastern region of Thailand. In chapter 11, Galloway traces important historical Burmese repatriation objects such as Pagan Buddha images and the Lion Throne, which were taken from Myanmar to British India in 1902 and returned in 1948. Interestingly, she points out that Buddhism and the worship of Nats spirits discourage an attachment to objects that are linked to bad luck, which is why repatriation never became an important issue in Myanmar. Returning Southeast Asia's Past: Objects, Museums, and Restitution provides important case studies on the subjects of repatriation, the law of provenance, object ownership and related political issues. It also has important bibliographic sources for Southeast Asian studies, art history, history and museum studies.


CORDIC (Coordinate Rotation Digital Computer) is an iterative digital algorithm, which allows rapid rotation of coordinates in the digital plane. The CORDIC can be used for the calculation of trigonometric functions. This iterative method of performing the transformations uses only shifts and adds. Significant savings in hardware can be achieved through the implementation of the heterodyne circuits of modulators, demodulators and filters using the CORDIC algorithm. In particular, significant hardware savings can be achieved in the implementation of a digital heterodyne filter in VLSI using the CORDIC algorithm.


Some formal ontological relations are identified, in the context of an account of ontological categorization. It is argued that neither formal ontological relations nor ontological categories should themselves be regarded as elements of being, but that this does not undermine the claim of formal ontology to be a purely objective science. It is also argued that some formal ontological relations, like some ontological categories, are more basic than others. A four-category ontology is proposed, in which two basic categories of universals and two basic categories of particulars are distinguished in terms of certain formal ontological relations characteristically obtaining between entities belonging to the different categories.


<italic>We show that for any set &Pgr; of n points in three-dimensional space there is a set Q of &Ogr;(n<supscrpt>1/2</supscrpt> log<supscrpt>3</supscrpt> n) points so that the Delaunay triangulation of &Pgr; ∪ Q has at most &Ogr;(n<supscrpt>3/2</supscrpt> log<supscrpt>3</supscrpt> n) edges — even though the Delaunay triangulation of &Pgr; may have &OHgr;(n<supscrpt>2</supscrpt>) edges. The main tool of our construction is the following geometric covering result: For any set &Pgr; of n points in three-dimensional space and any set S of m spheres, where each sphere passes through a distinct point pair in &Pgr;, there exists a point x, not necessarily in &Pgr;, that is enclosed by</italic> &OHgr;(<italic>m</italic><supscrpt>2</supscrpt>/<italic>n</italic><supscrpt>2</supscrpt> log<supscrpt>3</supscrpt> <italic>n</italic><supscrpt>2</supscrpt>/<italic>m</italic>) <italic>of the spheres in S.</italic>
par><italic>Our results generalize to arbitrary fixed dimensions, to geometric bodies other than spheres, and to geometric structures other than Delaunay triangulations.</italic>


The invention concerns a method of producing hydrophilic or partially hydrophilic inorganic aerogels. The method is characterized in that a hydrophobic inorganic aerogel is pyrolyzed in the presence of oxygen at temperatures ranging from 100 to 1000 DEG C.


The recent WHO list of the main 'killers' in high-income countries, such as the USA and Australia, comprises many noncommunicable diseases including ischemic heart disease, stroke and chronic pulmonary disease...


ABSTRACT Past scholarship has offered varying explanations for why presidents choose to use executive orders. However, to this point, much of what we know of unilateral powers does not adequately address the role the bureaucracy plays in the president's decision. This research seeks to account for bureaucratic factors as a strategic presidential consideration in the employment of such directives. I classify executive orders from 1989–2012 based on which agency or agencies they apply to, and consider the importance of various characteristics (e.g. agency ideology, level of centralization, politicization, etc.) in determining which organs of the bureaucracy presidents will direct executive orders to generally. The results provide evidence that the White House directs fewer executive orders to agencies that have a politically independent leadership structure, and this result holds across a variety of measures judging an order's impact. The results demonstrate that the type of directive is crucial in determining a president's strategic decision to use executive orders, in line with previous research, and that agency centralization is one crucial component of this strategic calculation.


Simple Summary In order to explore the biological role of Fas-associated factor 1 (FAF1) in testes and ovaries of domestic yaks, we examined the mRNA, protein expression and tissue localization of FAF1 in the ovaries of different ages and reproductive cycles in domestic yaks. The results showed that FAF1 mRNA and protein were expressed differently in the ovaries of testes of different ages and different reproductive cycles, mainly expressed in sperm, sperm cells, spermatogonia, primary spermatoblasts, supporting cells, testesian stromal cells and periductalcells in the testes, germinal epithelial cells, granule cells, cumulus cells, follicular membrane cells and luteal cells of ovarian tissues, and it was speculated that FAF1 may be closely related to the testicular development, spermatogenesis and testosterone secretion of male domestic yaks, and to the follicular atresia of female domestic yaks. Development, maturation and luteal lysis physiological processes are related, which provides a basis for further exploration of FAF1 in the reproductive physiological function of domestic yaks. Abstract Fas-associated factor 1 (FAF1), a member of the Fas family, is involved in biological processes such as apoptosis, inflammation, cell proliferation and proteostasis. This study aimed to explore the biological role of FAF1 in testicular tissue at different ages (juveniles (1 and 2 years old), adults (3, 4, 6, and 7 years old) and old-aged animals (11 years old)) and ovaries during different reproductive cycle phases (follicular, luteal, and pregnancy phases). FAF1 mRNA, relative protein expression and protein expression localization were determined in testes and ovaries using real-time quantification, WB and immunohistochemistry (IHC), respectively. Real-time quantification of testis tissues showed that the relative expression of FAF1 mRNA in testis tissues at 3, 4 and 7 years of age was significantly higher than of those in other ages, and in ovarian tissues was significantly higher in luteal phase ovaries than those in follicular and pregnancy phase ovaries; follicular phase ovaries were the lowest. WB of testis tissues showed that the relative protein expression of FAF1 protein was significantly higher at 11 and 7 years of age; in ovarian tissue, the relative protein expression of FAF1 protein was significantly higher in follicular phase ovaries than in luteal and pregnancy phase ovaries, and lowest in luteal phase ovaries. The relative protein expression of FAF1 at 3, 4 and 7 years of age was the lowest. IHC showed that FAF1 was mainly expressed in spermatozoa, spermatocytes, spermatogonia and supporting cells; in ovarian tissue, FAF1 was expressed in ovarian germ epithelial cells, granulosa cells, cumulus cells and luteal cells. The IHC results showed that FAF1 mRNA and protein were significantly differentially expressed in testes of different ages and ovarian tissues of different reproductive cycle phases, revealing the significance of FAF1 in the regulation of male and female B. grunniens reproductive physiology. Furthermore, our results provide a basis for the further exploration of FAF1 in the reproductive physiology of B. grunniens.


The present invention relates to an image registration method acquired by at least one imaging system. The method comprises the steps of: - positioning at least a first sensor (S) integral with the imaging system, - positioning at least one second sensor (P) so as to make it integral with the movements of an organ of a patient is taken at least two images, - acquiring the positions of said sensors (S, P) for acquisitions of images- image registration based on the sensor positions (S, P) .A further object of the a system of images acquired by a least one imaging system comprising registration means for acquiring the position of at least a first integral sensor of the imaging system and at least a second sensor secured to the movement of an organ of a patient is taken at least two images, the registration being performed based on the sensor locations at the time of image acquisition.


I N a talk to the GroupAnalytic Society (London) in 1982, I outlined an existential approach to psychotherapy, saying that in my opinion group work was more manifestly 'existential' than other forms of therapy. Here are some reflections to elaborate this view. There are many ways in which we can group the various schools of psychotherapy. A distinction I find most helpful is between those models that emphasize the interplay of forces within the individual and those that stress the interaction betiteeiz individuals. (Greenberg and Mitchell (1 983), in their fundamental book on object-relations, make a similar distinction between what they call 'drive/structure' and 'relational/structure' models.) Within psychoanalysis the big shift occurred with Fairbairn's move to seeing the libido as object-seeking rather than pleasure-seeking. In spite of an 'objectifying' terminology, object-relations theory puts the relationship between persons, particularly between mother and child, into the centre of its concern. So too do John Bowlby's considerations of attachment developed at about the same time and Sullivan's 'interpersonal' approach. Winnicott, though a t first influenced by Melanie Klein (whose interests, as I see it, were predominantly intra-psychic), came to develop his own ideas about the central importance of the interplay between mother and child. Group analysis, by its very nature, is concerned with the relation of people to each other, with interaction and context. Foulkes, in his first book (1948), considered that 'each individual itself an artificial, though plausible abstraction is basically and centrally determined, inevitably, by the world in which he lives . . .': he is 'part of a social network, and can only artificially be considered in isolation . . .'. Twenty-one years before this was written, a seminal philosophical work


A man who runs a Wednesbury roof company which charged £11,500 for a "patchwork quilt" roof by using inappropriate tiles has been found guilty of three charges at Wolverhampton Crown Court.


Suqin Zheng, Suojun Yuan, Longjun Zhou 1. School of Educational Science, Jiangsu Second Normal University, Nanjing 211200, Jiangsu, China 2. Jiangsu Second Normal University, Nanjing 211200, Jiangsu, China; and Engineering Research Center of Digital Learning Support Technology, Ministry of Education, Changchun 130000, Jilin, China Correspondence to: Dr. Longjun Zhou, Ph.D., Email: email@example.com Funding: This study was supported by the Jiangsu University Philosophy and Social Science Research Major Project (Project approval #: 2020SJZDA110). DOI: https://doi.org/10.15354/si.21.or103 The authors declare no competing interest.


The invention discloses a plant growth regulator containing cycocel and compound sodium nitrophenolate mixture, which comprises the effective ingredients: cycocel and compound sodium nitrophenolate, wherein the weight ratio of the cycocel and the compound sodium nitrophenolate is 10: 1 to 10, and the mass fraction of the cycocel and the compound sodium nitrophenolate in the mixture is 30 to 80 percent. The plant growth regulator is used for controlling the excessive vegetation growth of the crops, promoting the increase in yield of the crops and for improving the quality of the crops.


Hydrogen bond mediated films made by step by step deposition of poly(4-vinylpyridine) (P4VP) and hydroxylated poly(2,3,4,5,6-pentafluorostyrene) (PPFS) copolymers prepared by thiol para-fluoro coupling, bearing either one (PPFSME) or two (PPFSMPD) hydrogenated hydroxyl groups or a (poly)fluorinated hydroxyl (PPFSOH), respectively, were successfully constructed. The influence of the structural parameters, such as the hydroxyl environment (which dictates the H-bond strength) was in-depth investigated in terms of their impact on (i) growth mechanism, (ii) internal organization, and (iii) surface features. The use of the weaker H-bond donor partner (PPFSME) leads to low quality films composed of irregularly distributed aggregates. While [PPFSMPD/P4VP] multilayer films are comparatively thick and composed of stratified layers with smooth topology, the use of PPFSOH with P4VP yields thin films made of mixed and interpenetrated polymer layers. Playing on the interaction strength appears as a powerful tool to elaborate tailored multilayer films with molecularly tunable properties.


Objective To observe the expression of KDRn3 protein in human umbilical vein endothelial cells (HUVECs) as well as the inhibitory effect of expressed product on the proliferation of HUVECs. Methods Plasmid pEGFP-N1 / KDRn3 constructed previously was amplified and identified, then transfected to HUVECs in mediation of liposome. Culture the transfected HUVECs for a certain time, then observe the expression of green fluorescent protein by fluorescent microscopy, determine the KDRn3 content in culture supernatant by ELISA and the proliferation level of HUVECs by MTT method. Results Green fluorescence was observed in the HUVECs 48 h after transfection with pEGFP-N1 / KDRn3. However, both the number of HUVECs showing green fluorescence and the fluorescence strength increased 72 h after transfection. The KDRn3 contents in cell culture supernatant 24, 48 and 72 h after transfection were significantly higher than those before transfection. The proliferations of HUVECs 48 and 72 h after transfection with pEGFP-N1 / KDRn3 were significantly inhibited as compared with those of control. Conclusion KDRn3 protein was expressed in HUVECs and inhibited the proliferation of the latter.


A Molecular Attack on Myeloid Leukemia Chronic myeloid leukemia (CML) results from a mutation that disrupts two genes, ABL and BCR, on chromosomes 9 and 22, respectively. The mutation-a reciprocal translocation of DNA-creates the fusion genes BCR-ABL (on a cytogenetically abnormal Philadelphia chromosome) and ABlrBCR. The former encodes BCR-ABL, a deregulated tyrosine kinase present in virtually all CML patients and required for oncogenicity. BCR-ABL induces leukemia in mice. With all of this in mind, investigators at centers including the Oregon Health Sciences University and Novartis Pharmaceuticals designed imatinib mesylate (previously designated STI 571, or signal transducing inhibitor 571), a drug that prevents the kinase from phosphorylating its substrate. In a phase 1, dose-escalating trial, imatinib was administered orally to 83 CML patients unresponsive to conventional a-interferon therapy. During a median of 310 days, imatinib was generally well tolerated. Complete hematologic responses were obtained in 53 of the 54 patients treated daily with doses of 300 mg or more. Cytogenetic responses occurred in 54% of these subjects. In seven, the response was a complete cytogenetic remission. In a companion study by the same investigators, imatinib produced hematologic responses in 21 (55%) of 38 CML patients in myeloid blast crisis, seven of whom remained in remission after 101 to 349 days. Fourteen of 20 patients with lymphoid blast crisis or Philadelphia-chromosome-positive acute lymphoblastic leukemia also responded but eventually experienced a relapse. Imatinib has already been approved by the Food and Drug Administration; review of the drug's clinical data was completed within 2.5 months.


An angular vertical comb-drive (AVC) with electrically controllable initial comb-offset is presented in the context of a single crystalline silicon scanning micromirror. The electrothermal actuated control of the variable offset is used to investigate the influence of the initial comb offset on the dynamic resonance behavior of the scanning mirror. With possible maximum vertical comb-offsets between 10 μm and 5 μm a higher dynamic mirror scan angle at the mechanical resonance frequency of 6 kHz is found for higher initial offsets. The same behavior of higher scan angles for higher offsets is also shown when mechanically controlling the initial comb-offset including negative offset values and offsets close to 0 μm.


OBJECTIVE To determine the content of ginsenoside Rb 1 in Shengmaizengyetong capsulae.METHODS The determination was performed by RP HPLC using ODS column acetonitrile water (28∶72) as the mobile phase with the detective wavelength of 203 nm at 30℃.RESULTS The average recovery was 96.69% with RSD 0.996%.CONCLUSION This method appeared to be accurate and highly reproducible.It can be used as a method for quality control of Shengmaizengyetong capsulae.


The concerto evidently appeals to HK Gruber, as symphonies do not. He has so far written four works that are unambiguously in this form: '…aus schatten duft gewebt…', a concerto for violin and orchestra of 1977–8; the concerto for percussion and orchestra Rough Music (Rauhetöne) of 1982–3; Nebelsteinmusik, for solo violin and string orchestra, of 1988; and the Concerto for Cello and Chamber Orchestra of 1989. Ambiguous examples of the form are his early Concerto for Orchestra (1960–64) – concertos for orchestra are by definition ambiguous – and Frankenstein!!, his 'pan–demonium' (rather than 'concerto') for baritone chansonnier and orchestra (on children's rhymes by H.C. Artmann), finalized in 1977. Then there are four works which remain in manuscript (withdrawn from circulation): Concerto No. l for flute, vibraphone, xylophone and percussion (1961); Concerto No. 2 for tenor saxophone, double bass and percussion (1961); 'furbass' for double bass and orchestra; and an unsatisfactory forerunner of the violin concerto, Arien (1974–5). The symphony he has not touched; and one is tempted to see in this reliance on solo/ensemble confrontation an attempt to hold together the self–splintered, all too globally diversified language of the late 20th century by an eloquent soloist's sheer persuasiveness, by musical force, so to speak, the soloist being dramatized as a kind of Atlas. In the same way Gruber's recourse to popular songs and idioms of 'light music' in these works can seem like a desperate attempt to find a tonal prop and sanction for a language so pervasively threatened by tone–deafness and gobbledygook.


Character design is the soul of an animation work, and its status is equivalent to the selection of movie actors. At present, most colleges and universities offer animation majors, but there are many problems in the animation character design courses for animation majors, such as students' low awareness of animation characters, less enthusiasm for class, and lower level of works. After investigating related industry companies, the author believes that at present, animation companies have a large demand for talents in pre-animation design (including character design). Therefore, teachers should make a reasonable teaching plan based on this. Teachers should introduce practical cases in teaching, introduce real projects in the corporate industry into the classroom, and improve the assessment system, which can improve students' practical ability and thus provide excellent talents for the industry.


Summary In the years 1878 and 1879 the American physicist Alfred Marshall Mayer (1836–1897) published his experiments with floating magnets as a didactic illustration of molecular actions and forms. A number of physicists made use of this analogy of molecular structure. For William Thomson they were a mechanical illustration of the kinetic equilibrium of groups of columnar vortices revolving in circles round their common centre of gravity (1878). A number of modifications of Mayer's experiments were described, which gave configurations which were more or less analogous to Mayer's arrangements. It was Joseph John Thomson who, in publications between 1897 and 1907, used Mayer's results to obtain a good deal of insight into the general laws which govern the configuration of the electrons in his atomic model. This article is mainly concerned with Mayer's experiments with floating magnets and their use by a number of physicists. Through his experiments Mayer made a significant, although small, contribution to ...


The present invention provides a method for eliminating a multi-pass laser cladding overlapping holes. In this method, the laser power density and the relationship between the aspect ratio of the cladding layer single-channel, single channel to determine the optimal aspect ratio of the cladding layer; single-channel relationship cladding aspect ratio can be calculated according to the determined process parameters employed parameters, pitch and overlap to eliminate multi-pass laser cladding overlapping holes. The present invention eliminates overlapping multi-pass laser cladding method can eliminate overlapping holes holes in the cladding layer, can also reduce cracking sensitivity cladding, the cladding layer to improve life.


Thanks to the work of a number of scientists who made it known that severe space weather can cause extensive social and economic disruptions in the modern high‐technology society. It is therefore important to understand what determines the severity of space weather and whether it can be predicted. We present results obtained from the analysis of coronal mass ejections (CMEs), solar energetic particle (SEP) events, interplanetary magnetic field (IMF), CME‐magnetosphere coupling, and geomagnetic storms associated with the major space weather events since 1998 by combining data from the ACE and GOES satellites with geomagnetic parameters and the Carrington event of 1859, the Quebec event of 1989, and an event in 1958. The results seem to indicate that (1) it is the impulsive energy mainly due to the impulsive velocity and orientation of IMF Bz at the leading edge of the CMEs (or CME front) that determine the severity of space weather. (2) CMEs having high impulsive velocity (sudden nonfluctuating increase by over 275 km s−1 over the background) caused severe space weather (SvSW) in the heliosphere (failure of the solar wind ion mode of Solar Wind Electron Proton Alpha Monitor in ACE) probably by suddenly accelerating the high‐energy particles in the SEPs ahead directly or through the shocks. (3) The impact of such CMEs which also show the IMF Bz southward from the leading edge caused SvSW at the Earth including extreme geomagnetic storms of mean DstMP < −250 nT during main phases, and the known electric power outages happened during some of these SvSW events. (4) The higher the impulsive velocity, the more severe the space weather, like faster weather fronts and tsunami fronts causing more severe damage through impulsive action. (5) The CMEs having IMF Bz northward at the leading edge do not seem to cause SvSW on Earth, although, later when the IMF Bz turns southward, they can lead to super geomagnetic storms of intensity (Dstmin) less than even −400 nT.