COVID-19 pandemic has been associated with increased morbidity, mortality and economic loss globally. In the absence of definitive treatment, the only way to develop herd immunity and to curtail the spread of infection is through an effective vaccination programme. Under normal circumstances, a vaccine development would have taken 8–12 years; however, in case of COVID vaccine, this process has been reduced to 10 months. Since the lockdown, multiple countries have used various platforms to develop COVID vaccines at a war footing and recently close to five vaccines that have been approved for emergency use. This has lead to confusion, controversy and debate among the medical fraternity about the safety and efficacy of these vaccines. This articles gives an overview of the vaccines present, various trial results and adverse effects seen till now.


The Kurdish case considered one of the most important issues in the modern history of Iraq, and the problem of the Kurds is represented by their demand for rights that guarantee their national and linguistic distinction, and the inclusion of these rights in laws and constitutions, and most Iraqi governments have responded, these demands were rejected, and some of them were rejected, including the annexation of Kirkuk, the oil-rich region, to the Kurdish areas, which sparked a dispute between the two sides and led to bloody clashes. The research deals with the Kurdish case in Iraq from 1958-1963, which is the period of rule of Abd al-Karim Qasim, the leader of the July 14 revolution in Iraq, which ended the monarchy. The research was divided into three axes. The first axis is the position of the Kurds in support of the revolution and the privileges granted by Abdul Karim Qassem to the Kurds, including the approval of the new Iraqi constitution, some articles that include the national rights of the Kurds. For the Kurds and allowed the return of the exiles to Iraq, including Mustafa Barzani, and the release of Kurdish detainees in Iraqi prisons since the royal era. The second axis included bad relations between Abdul Karim Qasim and the Kurds. The last axis dealt with the armed clash between the two, which lasted from 1960 to 1963, the year in which the rule of Abd al-Karim Qasim ended after his overthrow, and the Kurds allied with the revolutionaries to achieve their demands for autonomy. The study relied on a set of sources, including published American documents, as well as books, including the book Northern Iraq 1985-1975 by the author Ammar Ali Al-Samar. And the book Political Currents in Iraqi Kurdistan, a reading in the files of the Kurdish movements and parties in Iraq 1946-2001, by the author, Salah Al-Khursan, in addition to theses, university theses, and a group of research and studies.


The Helmholtz equation–least‐squares (HELS) method [Wang and Wu, J. Acoust. Soc. Am. 102, 2020–2032 (1997); Wu, J. Acoust. Soc. Am. 107, 2511–2522 (2000)] has been proven a reliable acoustic holography method. The main advantages are its simplicity in formulations, flexibility in measurement locations, and uniformity in algorithm for a variety of source geometry and conditions. This paper presents a complete acoustic holography system based on the HELS method that makes full use of these advantages. This system has been under development as part of an ongoing research at the Acoustics, Vibration, and Noise Control Laboratory at Wayne State University. The physical setup will be described which includes the front‐end multichannel data acquisition system and the associated hardware. Experimental results on reconstruction of the radiated acoustic fields from a complex source using this system will be demonstrated. Comparisons of this system with other acoustic holography systems currently available will be m...


Based on the related theories of industrial clusters,this article reveals the cluster characteristic and cluster effect of the technology business incubators of our country,it analyzes the cluster evolution of the incubators in their longitudinal and transverse development,and puts forward some countermeasures and suggestions from the angle of cluster for the development of incubators as to promote the hi-tech industry.


As beings who live facing others, we have a peculiarity of trying to lead a human life from a very human perspective. These relationship-centered singularities can be explained from a psychological point of view, especially based on the fact that Emmanuel Levinas is a clue to emotion and moral sensitivity. Human tendencies are relational and have the ability to listen to the object's verbal and nonverbal expression behavior as a positive characteristic in forming human relationships. This provides a theory of the human element of facing and moral temperament in the attitude of empathizing with the other person, and above all, it can be understood as the positivity of human emotional activities.
We must choose correctly while the inner voice and the moral command of pure reason coexist. Levinas' sensitivity is a sympathetic emotional listening that spreads from the face to the face resulting from the other. This study attempts to prove the moral relevance of these concepts based on Levinas' theory of correct choice and ethical responsibility based on data on the situation of human relationship-forming ability of listening attitude, accountability, and moral sensitivity.


In the present days, medicinal plants receive great attention to the researchers in the field of pharmacology, due to the fact that most of the drug industries rely on natural products more especially medicinal plants for the production of new drugs. Some traditional medicines and their derived products were often made from crude plant extracts, which include a mixture of complex different phytochemical constituents. The chemical features of these constituents vary substantially among different species. Gas chromatography and Mass spectroscopy (GC-MS) method used for the analysis of the obtained extracts can be a remarkable tool for screening the quantity of some active principles in herbs used in pharmaceutical industries. The identification of secondary metabolites is based on the peak area, retention time-molecular weight, molecular formula, MS Fragment- ions and Pharmacological Actions. The aim of this study was to carry out for identification of bioactive compounds from the leaf ethyl acetate and methanolic extract of Artocarpus altilis  by (GC-MS). Fifty and fifteen bioactive phytochemical compounds were identified in the methanolic and ethyl acetate extracts respectively. GC/MS analysis revealed the existence of Acetic acid, n-Hexadecanoic acid, 1,2,3-Propanetriol, 1-acetate (Acetin), Hexadecanoate , 7-Tetradecenal, in the methanol extract while the ethyl acetate extract revealed the presence of 3, 7-dimethyl-2, 6-octadienal (Geranial-pseudo phytol), 3,7,11,15Tetramethyl-2-hexadecen-1-ol (Phytol), Piperonal and Heliotropin. Further studies are needed to isolate active principle of the extract as well as to elucidate their exact mechanism of action in various disorders.


There is a problem with looking at faith and politics in American public discourse, but it is probably not the one that you think. Having little to do with the separation of church and state, the problem lies in what we actually discuss. In the end, it just doesn't seem very useful or revealing about the role of faith in everyday life. While election exit polls focus on religious affiliation and rate of attendance, these metrics tell us little about how people's beliefs work. In 2008, I ran a research project through Northwestern's Kaplan Institute for the Humanities exploring the role that belief plays in people's electoral decision-making. Previous research focused on polls and single-session focus groups, but I was interested in talking to people over a longer period of time. Using three discussion groups in New Hampshire and five in the Chicagoland area, we focused on the impact of a candidate's beliefs, how the campaigns targeted religious voters, how the media covered religion, and most importantly for me, how their own beliefs influenced their political choices. In the initial meetings, I generally got a standard rant, a rehashing of conventional wisdom around the evils of mixing religion and politics, but then something interesting happened. We kept on meeting. Once we got past everyone's bullet points, people became more reflective. Nuance, and even confusion, took the place of black and white surety. For example, many liberals in my groups stated that their beliefs played no role in who they chose to support in the election. In fact, they were a little offended by the question. However, over time they each articulated a clear role that their personal beliefs played in shaping how they think and live. When I would try to connect the dots, adding politics, they seemed perplexed. They would first agree, but then suddenly (often vehemently) deny that their beliefs played any role. The reason, I think, is cultural and not religious. Liberal minded people have associated religious voting with the "Religious Right," and to let faith impact their vote was tantamount to admitting that they were like "those people." Even though their own stories (delivered in their own words) showed how their beliefs shaped their world, they rebelled against the association. For theatre and performance scholars, this disconnect is of significant importance for it turns out that analyzing politics and belief comes down to the same tools already we use. It is not enough just to look at The Problem of Faith and Politics (It's Not What You Think)


Let me try to throw a philosophical spotlight on the topics of value change and new ethics in modern society by pursuing the question: in what sense and why is it symptomatic of the situation of the sciences and higher education, that both express the need today for a new ethic, i.e. an ethic of unlimited responsibility for the planet and for the future on the one hand, but deny or doubt the rational foundation of such an ethic?


Nowadays, non-contact vital sign measurement from facial videos using an RGB camera has gained popularity among researchers as it is a feasible and convenient method suitable for personalized and clinical health monitoring. This paper proposes a simple but cogent technique for heart rate (HR) estimation from the facial RGB videos. It is suggested that the integration of color channels from different color spaces derived from the RGB model can provide a better estimation of the pulsating component of arterial blood synchronous with the cardiac cycle. The shared pulse signal related to blood volumetric changes underneath the skin existing in these color signals is separated using the principal component analysis, and the resultant signal is used to determine the HR value using the short-time Fourier transform. The experiments are performed using three publicly available datasets including PURE, UBFC-rPPG, and Cohface. In the experimental analysis, the proposed technique yields lower values of the mean absolute error (MAE) and root mean square error (RMSE) for the three datasets as, PURE: MAE = 1.65 beats per minute (bpm) and RMSE = 2.9 bpm, UBFC-rPPG: MAE = 2.57 and RMSE = 5.57 bpm, and Cohface: MAE = 4.51bpm and RMSE = 6.5 bpm. These performance measures for the proposed technique are found to be lower than those obtained from some of the state-of-art methods. This study suggests that color channels from the alternative color spaces can be used for non-contact vital sign monitoring.


Disasters whether natural or man-made, pose major challenge to human health and development in Africa; their impact on the health of individuals and communities are often severe and could hinder attainment of global, regional, and national development goals (1–3). Recent disasters in Africa aptly illustrate the complex interaction between health systems and disasters; a vicious cycle in which weak health systems provide fertile grounds for deterioration of public health and natural hazards into disasters while on the other hand, disasters further decimate already weak health systems (4). The sustained transmission of the 2014/15 Ebola virus disease outbreak in Guinea, Liberia, and Sierra Leone was consistently linked to the weak health systems in these countries (5, 6). The outbreak resulted in the death of several health workers (7), depletion of scarce financial resources, diversion of medical equipment. This in addition to overburdening of already weak health information and supply chain management systems resulted in disruption of health services delivery in these countries (8–10). Other disasters such as the Yellow Fever outbreaks in Angola, Democratic Republic of Congo and Uganda, and ongoing armed conflicts in South Sudan, Central Africa Republic, northeast Nigeria, and other African countries also had similar consequences (11–15). This pattern is not limited to Africa; the fragile pre-disaster health systems in the city of New Orleans in America and the Eastern Visayas Region of the Philippines contributed to the public health consequences of Hurricane Katrina and Haiyan (Yolanda) and constrained timely and effective post-disaster health system recovery efforts (16, 17). The preKatrina health system in the city of New Orleans was characterized by low coverage of health insurance and reduced access to health services by the largely poor population of the city (16). Similar challenges such as inadequate health-care infrastructure, staffing, and low coverage of health insurance, which reduced access to health services were also prevalent in the affected areas of the Philippines pre-Hurricane Haiyan (17). The Sendai Framework for Disaster Risk Reduction (SFDRR) and sustainable development goals (SDGs), both of which are landmark United Nations agreements adopted in 2015, recommend scaling up implementation of disaster risk reduction (DRR) strategies as means to improve resilience to disasters globally (18, 19). The SFDRR in contrast to its predecessor, the Hyogo Framework for Action, puts a lot of emphasis on health (20). It proposes resilient health systems as an opportunity


Random walks describe diffusion processes, where movement at every time step is restricted to only the neighboring locations. We construct a quantum random walk algorithm, based on discretization of the Dirac evolution operator inspired by staggered lattice fermions. We use it to investigate the spatial search problem, that is, to find a marked vertex on a d-dimensional hypercubic lattice. The restriction on movement hardly matters for d > 2, and scaling behavior close to Grover's optimal algorithm (which has no restriction on movement) can be achieved. Using numerical simulations, we optimize the proportionality constants of the scaling behavior, and demonstrate the approach to that for Grover's algorithm (equivalent to the mean-field theory or the d -> infinity limit). In particular, the scaling behavior for d = 3 is only about 25% higher than the optimal d -> infinity value.


The novel coronavirus disease 2019 (COVID-19) was characterized as a global pandemic by the World Health Organization (WHO) on March 11, 2020. The present pandemic has caused an intolerable impact on the health structure as well as the pharmaceutical sector, which in ultimatum has created enormous issues in the everyday lives of the patient community. On the other hand, the situation may appear in short and long-term time-horizon and need identification along with appropriate planning to reduce their socio-economic burden. The Indian pharmaceutical industry is the world's third-largest drug producer by volume. India supplies affordable and low-cost generic drugs to millions of people around the globe and operates more than 250 United States Food and Drug Administration (USFDA) and United Kingdom Medicine and Healthcare products Regulatory Agency (UKMHRA) approved plants. Given the Indian pharmaceutical industry, the source of Active Pharmaceutical Ingredients (APIs) for multiple diseases is much crucial part of the Pharma industry's strategic plan to combat the COVID-19 pandemic. China is the top global producer and exporter of APIs by volume and Indian pharmaceutical industries are also rely heavily on APIs from China for the production of their medicine formulations by importing around 70 percent of the total requirement. However, the present pandemic situation has exposed the world's over-reliance on China in terms of API import and bound world leaders to fig. out sustainable alternatives.


The hydrolysis of acetylated starches with different subsitutions degrees was conducted with an enzyme active at 90°C. The extent of degradation was evaluated by colorimetric and chromatographic methods.

With slightly acetylated starches, 100% of the substrate was fragmented and the main product obtained was maltose. The classification of these different substrates according to their percentage of biofragmentation was the same with the two methods.

With highly acetylated starches, the degradation was lower and the decomposition products are mainly maltose, maltotriose and pentaose. The classification of the different substrates was also the same with the two methods. Moreover, the values of the kinetic parameters confirmed these classifications.


The paper aims to report on the main initiatives developed by the Brazilian Agricultural Research Corporation (Embrapa) on open access to scientific and technological information, as well as initiating the organization and availability of research data. For this purpose, a history is made, starting in 2008, when the Company, through an internal project, consolidated several actions in the scope of information management, especially the publication of its open access repositories (Alice and Infoteca-e). Next, more recent initiatives are described, such as the Open Access scenario developed within the framework of a strategic institutional project on data, information and knowledge governance, initiated in 2015 and finalized in 2017, which presented a series of guidelines to be observed on the theme by the managers and the community of Embrapa with the purpose of aligning it with the international trends.


A digital still camera image processing system on chip is presented in this paper The still camera system is different from a video camera system in many aspects. In a video camera system, many problems like slight color errors, random noises and some kind of artifacts would be averaged away by freshening operation, but they would be unacceptable in a still camera system. Therefore modules on the chip like AE/AF/AWB are designed as re-constructive, so camera makers could easily use basic functions on the chip to develop their products with their special know-how. The system also can process both a primary color and a complementary color image data array.


The article deals with the ontological multifunctional (multidimensional) language and is closely related to its phatic function. It is shown that after the 60s of the twentieth century the phatic function of language, phatic itself, essence and purpose of phatic communication, phatic speech genres have been comprehensively studied in the west (especially in Russian) philologies, however, these questions in the Uzbek science are waiting to be explored.


Medicinal plant biotechnology: from basic research to industrial applications , Medicinal plant biotechnology: from basic research to industrial applications , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی


Abstract The purpose of this study was to identify variables associated with tai chi group compliance among community-dwelling older adults. Twelve older adults participated in 10 classes, with an hour of taichi and a half-hour focus group, over a 5-week period. Focus group topics included exercise history, likes and dislikes of current group and instructor, and obstacles to learning tai chi. Tai chi was appealing to participants of all physical abilities, although those who dropped out appeared to have greater physical and cognitive limitations. Most participants found repetition and slow presentation of moves helpful. Many found it difficult to practice at home suggesting the potential utility of cues (e.g., audiotapes, videotapes, or printed materials) to facilitate home practice.


SINCE the new Government took office there has been predictable pressure on Sir Keith Joseph, the Secretary of State for Social Services, to make his views clear on a number of issues, but in line with the other members of the Government, he has been cautious in making any firm commitments at this stage. In a Parliamentary debate before the Summer recess he was challenged by Mrs. Barbara Castle, speaking for the Opposition, to explain how he would ensure the continuing expansion of the hospital-building program and maintain the present standard of the welfare services in the face of the . . .


Engineering drawing is a compulsory course for technical college students.It is important to research engineering drawing in network course,The multimedia network teaching will not be restricted by time,space and has various forms.This article discusses the practice of the course,and it also probes into the research in implementing this course.


The March 2011 Tohoku, Japan, tsunami caused severe damage to many buildings, bridges, and lifelines along the Pacific coast of Japan. To analyze its effects on structures, the tsunami flow velocity and the tsunami flow depth are needed to estimate the force acting on structures. Videos recording tsunami flows are available on many websites. Ten cases of tsunami flow velocities and flow directions are analyzed from videos by estimating the movement distances of observed objects. The analyzed tsunami flow velocities are 3–5 m/s in Kamaishi City, 2 m/s in Ofunato City, 3–6 m/s in Kesennuma City and 1.5 m/s in Iwaki City. The analyzed velocities fall in the range of 1.0 g h to 1.5 g h . A case study of tsunami simulation is performed to estimate the velocity in Kesennuma City. At the same locations as the recorded videos, the tsunami flow velocities from the simulation agree the velocities from recorded videos.


The formation and early evolution of low-mass young stellar objects (YSOs) are investigated using three-dimensional non-ideal magnetohydrodynamics simulations. We investigate the evolution of YSOs up to after protostar formation, at which protostellar mass reaches . We particularly focus on the impact of the dust model on the evolution. We found that a circumstellar disk is formed in all simulations, regardless of the dust model. Disk size is approximately 10 au at the protostar formation epoch, and it increases to several tens of au at after protostar formation. The disk mass is comparable to the central protostellar mass, and gravitational instability develops. In simulations with small dust sizes, the warp of the pseudodisk develops after protostar formation. The warp strengthens magnetic braking in the disk and decreases disk size. Ion-neutral drift can occur in the infalling envelope when the typical dust size is and the protostar (plus disk) mass is . The outflow activity is anticorrelated to the dust size, and the strong outflow appears with small dust grains.


Summary.

1
The family Empetraceae is described and its position in a natural classification is discussed. According to the cons nsus of modern opinion its proper place is either next the Ericaceae or as an additional tribe within that family.

2
The biology of the genus Empetrum is described.

3
Its geographical distribution is described in detail and the most important ecological features are noticed briefly.

4
Variation within the genus is described and is shown to be chiefly in seven characters:–general habit, degree of hairiness, shape and size of leaf, arrangement of leaves, angle of leaf-insertion, sex of flowers, colour of berry.

5
The morphological and geographical range of each of these seven characters is described in detail.

6
Variation as seen in these characters is of three kinds: simple continuous, complex continuous, and discontinuous.

7
It is shown that instead of an almost indefinite number of forms within the genus all the individuals fall into ten clearly differentiated groups. This is chiefly due to the combined influence of correlated variation and geographical segregation.

8
These ten groups are described.

9
Previous taxonomic work on the genus is briefly reviewed.

10
The inter-relationships of the ten groups comprising the genus are fully discussed and a taxonomic treatment is suggested, which is, in the writer's opinion, expressive of the conclusions reached in the discussion.

11
According to this classification the genus contains two species, one having a subspecies, a variety and three forms, the other having three forms.

12
In conclusion the methods adopted in the taxonomic treatment are described and discussed.

The writer gratefully acknowledges his deep indebtedness to the Directors of the Herbaria at Berlin, Upsala, Geneva, Copenhagen, Leningrad, and the Gray Herbarium for the loan of numerous specimens by which the detailed analysis of the genus was made possible. His thanks are also due to many friends who have offered valuable criticisms, advice and information, and to the Librarian of the Botanical Department of the British Museum (Nat. Hist.) for his help with the extensive literature of the genus.


Removal of hydrogen sulfide (H{sub 2}S) from coal gasifier gas and sulfur recovery are key steps in the development of Department of Energy's (DOE's) advanced power plants that produce electric power and clean transportation fuels with coal and natural gas. These plants will require highly clean coal gas with H{sub 2}S below 1 ppmv and negligible amounts of trace contaminants such as hydrogen chloride, ammonia, alkali, heavy metals, and particulate. The conventional method of sulfur removal and recovery employing amine, Claus, and tail-gas treatment is very expensive. A second generation approach developed under DOE's sponsorship employs hot-gas desulfurization (HGD) using regenerable metal oxide sorbents followed by Direct Sulfur Recovery Process (DSRP). However, this process sequence does not remove trace contaminants and is targeted primarily towards the development of advanced integrated gasification combined cycle (IGCC) plants that produce electricity (not both electricity and transportation fuels). There is an immediate as well as long-term need for the development of cleanup processes that produce highly clean coal gas for next generation power plants. To this end, a novel process is now under development at several research organizations in which the H{sub 2}S in coal gas is directly oxidized to elemental sulfur over a selective catalyst. Such a process is ideally suited for coal gas from commercial gasifiers with a quench system to remove essentially all the trace contaminants except H{sub 2}S In the Single-Step Sulfur Recovery Process (SSRP), the direct oxidation of H{sub 2}S to elemental sulfur in the presence of SO{sub 2} is ideally suited for coal gas from commercial gasifiers with a quench system to remove essentially all the trace contaminants except H{sub 2}S. This direct oxidation process has the potential to produce a super clean coal gas more economically than both conventional amine-based processes and HGD/DSRP. The H{sub 2} and CO components of syngas appear to behave as inert with respect to sulfur formed at the SSRP conditions. One problem in the SSRP process that needs to be eliminated or minimized is COS formation that may occur due to reaction of CO with sulfur formed from the Claus reaction. The objectives of this research are to formulate monolithic catalysts for removal of H{sub 2}S from coal gases and minimum formation of COS with monolithic catalyst supports, {gamma}-alumina wash coat, and catalytic metals, to develop a regeneration method for a deactivated monolithic catalyst, to measure kinetics of both direct oxidation of H{sub 2}S to elemental sulfur with SO{sub 2} as an oxidizer and formation of COS in the presence of a simulated coal gas mixture containing H{sub 2}, CO, CO{sub 2}, and moisture, using a monolithic catalyst reactor. The task of developing kinetic rate equations and modeling the direct oxidation process to assist in the design of large-scale plants will be abandoned since formulation of catalysts suitable for the removal of H{sub 2}S and COS is being in progress. This heterogeneous catalytic reaction has gaseous reactants such as H{sub 2}S and SO{sub 2}. However, this heterogeneous catalytic reaction has heterogeneous products such as liquid elemental sulfur and steam. Experiments on conversion of hydrogen sulfide into elemental sulfur and formation of COS were carried out for the space time range of 46-570 seconds under reaction conditions to formulate catalysts suitable for the removal of H{sub 2}S and COS from coal gases and evaluate their capabilities in reducing hydrogen sulfide and COS in coal gases. Simulated coal gas mixtures consist of 3,200-4,000-ppmv hydrogen sulfide, 1,600-20,000-ppmv sulfur dioxide, 18-27 v% hydrogen, 29-41 v% CO, 8-12 v% CO{sub 2}, 0-10 vol % moisture, and nitrogen as remainder. Volumetric feed rates of simulated coal gas mixtures to the reactor are 30 - 180 cm{sup 3}/min at 1 atm and 25 C (SCCM). The temperature of the reactor is controlled in an oven at 120-155 C. The pressure of the reactor is maintained at 40-210 psia. The molar ratio of H{sub 2}S to SO{sub 2} in the monolithic catalyst reactor is maintained approximately at 2 for all the reaction experiment runs.


: The experiment was conducted at Soil and Water Research Department Greenhouse, was carried out to study the effect of different levels of salinity stress on the barely crop also Study the effect of the water magnetization to reduce salinity effect and 15 N in plant parts. Lowest grain yield of 11.68 g pot -1 b y M 0 S 2 N 0 . This decrease in grain yield was by the low N fertilization and the salinity stress. Grain yield was 38.80 g pot -1 (M 0 S 2 N 4 ) with an increase averaging 232.2%. The lowest straw dry matter yield was 10.60 g pot -1 given by M 0 S 3 N 0 . Plants werfaced difficulty to absorb N because of salinity. The highest straw yield was 26.40 g pot -1 (M 1 S 0 N 4 ) with 149.1%. The highest straw N uptake was 197.9 by M1N4S0 with 343.7%. The lowest N uptake in grains was 117.9 g pot -1 by M 0 S 1 N 3 . The highest grains N uptake was 372.9 g pot -1 by M 0 S 2 N 2 216.3% increse N recovery by straw ranged was 0.11 to 7.76 g pot -1 due to M 0 S 0 N 3 and M 1 S 2 N 1 , respectively. The main effect of magnetization was an increase due to M 1 . The main effect of salinity show an increase in NR when the salinity was in medium rates. N recovery by grains ranged from 0.65 to 25.14 g pot -1 due to M 0 S 0 N 1 and M 1 S 1 N 1 , respectively.


The invention belongs to the field of CCD (charge-coupled device) spectral signal acquisition and transmission, relating to the technical field of integrated circuit design of optics, field programmable gate array and USB2.0 (universal series bus) protocols. The invention discloses a CCD spectral signal universal acquisition system based on FPGA and USB2.0 protocols. The overall system mainly consists of two big parts of a spectral signal generation unit and a data acquisition unit; the generation of spectral signals is controlled by an optical imaging module and an FPGA; a USB is matched with the FPGA to perform logic controlling and be responsible for acquiring the spectral signals; and a host computer is used for analyzing the result of the data. In order to meet the requirements of various different CCD sensors, an IO (input/output) of the FPGA is reserved as the interface between a system board and a sensor; an A/D (analog/digital) converter with CDS (central data system) relevant double-sampling characteristics is adopted to inhibit the dark current noise of the CCD sensor; an asynchronous FIFO (first input first output) is arranged on the FPGA sheet to perform large-capacity data buffering and clock domain conversion, and finally under the USB2.0 protocol interface, the acquired data in the FIFO is transmitted to the host computer to perform interface display and result analysis. According to the system provided by the invention, the purposes of transmitting and processing large-capacity data in real time and hardware versatility can be realized.


The study focuses on politeness of merchants and managers in the Minang tourism area in the use of aizuchi towards Japanese tourists in Padang city. Politeness in terms of the language used by Minang merchants in tourism areas can be seen in the daily lives of those who use the Kato Nan Ampek culture. The ampek kato are kato malereng, kato mandaki, kato manurun, and kato mandata. Based on the five characteristics proposed by Mynard, there are only three characteristics, namely expressing confirmation, showing concern, and surprise. These characteristics indicate a cultural attitude that uses Kato Nan Ampek, namely kato mandaki and kato mandata. Politeness that is done to Japanese people who have aizuchi culture, namely the response to the interlocutor varies depending on the place. In general, merchants and tourism object managers are very polite in order to attract tourists to their business. Because of the limitations in mastering the Japanese language, the characteristic forms shown by the merchants are only in the form of confirmation by using the words はい (hai), はい、そうです (hai sou desu), and the form of one's attention in the form of そうですね (sou desune), expressing doubts by using the phrase わかりません (wakarimasen). Meanwhile, the politeness given by merchants and tourism managers is based on the functions put forward by Horiguchi, namely stating that the interlocutor is listening, understanding the conversation, agreeing, and expressing feelings.


This symposium is on the use of simulation/gaming for training in the concepts, methods, and uses of advanced and lean manufacturing. In addition to a large range of manufacturing topics, a wide variety of learning topics is covered, as one might expect. They include evaluation, facilitator roles, e-learning, effectiveness, learning experience, and teamwork. I would like to thank the Guest Editors, Lisa Ncube and Doug McWilliams, as well as the authors and reviewers, for the work that they have put into bringing together such a varied and intriguing symposium. All those interested in advanced and lean manufacturing will find this collection to be invaluable. People involved with simulation/ gaming more generally will also learn much from these pages.


This paper solves the problem of adaptive fuzzy inverse compensation control for an uncertain nonlinear system whose actuator is subjected to generalized dead-zone nonlinearity. By defining a continuous connection function and combining with the mean-value theorem, the generalized dead zone is first decomposed into a nominal asymmetric dead zone multiplying an uncertain continuous input function. Afterward, a smooth inversion and its parameterization are further proposed such that a new expression of adaptive asymmetric dead-zone compensation error is established in Theorems 1 and 2. With such an expression, the fuzzy systems can be successfully embedded into a compensation structure to indirectly handle uncertain input dynamics. In addition, a separation scheme is developed to construct two online estimators. Based on the above design procedure, an adaptive inverse compensator for generalized dead zone is built eventually. With the backstepping iteration design of compensator input, an adaptive fuzzy controller is developed to establish the closed-loop system stability. Finally, two simulations are conducted to illustrate the effectiveness and applicability of the proposed control scheme.


In this paper, we look back to the theory evolution from flying goose mode to double-headed economy development mode of China. On the issue of whether the latter mode comes into existence, we redefine the conception of dominant industry; on the other hand, we probe into whether trade specialization coefficient is valid for the analysis to international competitive power. After the debate about China's turning point, we put forward our own assumption about economy development mode of present China.


Background: Cardiovascular Disease is a leading cause of preventable death. Cardiovascular risk factors' identification is the cornerstone for effective and early interventions decreasing the frequency of acute health-threatening events. Since adolescence and youth are very vulnerable stages to develop risky habits, we decided to run this study in the Multidisciplinary Universitary Camp for Research and Service.
Methods: A descriptive cross-sectional study was performed in the Multidisciplinary Universitary Camp for Research and Service in which 450 medical students from Colombia were assessed. After a probabilistic random simple sampling (n=50), we applied the World Health Organization test and Finnish Risk Score to calculate Cardiovascular and Diabetes Mellitus risk, respectively. We characterized the population by sociodemographic variables and anthropometric measurements.
Results: The study shows that from 18 participating universities (n=50), the mean age of the participants was 21.14 years (SD 7.3) of whom 40% were male and 60% were female. Overall, 92% have a low risk of cardiovascular disease, 6% are at moderate risk and 2% are at high risk. 92% have low risk of diabetes mellitus and 8% are at moderate risk of having diabetes mellitus in the long term.
Conclusion: The early identification of and intervention on risk factors could decrease significantly the onset of acute health-threatening cardiovascular pathologies. As medical students, adolescents and young adults are at risk of developing unhealthy habits which increase the incidence of cardiovascular disorders. The use of anthropometric measures and validated risk score scales is an appropriate way to get evidence for starting early interventions.


Accepted: 16.08.2021 In today's learning society, use of media and technology affects students in all educational levels. There are a number of studies conducted among university students in this context. However, adolescents, who are sensitively exposed to the negative effects of the excessive use of media and technology, have been neglected. The aim of this study is to investigate the association among adolescents' use of media and technology, their academic procrastination behavior, and academic achievement. This study also examines the possible mediating effect of academic procrastination behavior on the relationship between adolescents' media and technology use and academic achievement. This quantitative study included data from 1278 middle and high school students. We collected data via a questionnaire comprising of the demographic information form, media and technology usage and attitude scale, and academic procrastination behavior scale as well as students' grade point averages to measure students' academic achievement. The results revealed that as media and technology usage increased, students' academic achievement decreased. In addition, academic procrastination behavior had a mediating effect on this relationship. In other words, adolescents' media and technology use cause academic procrastination behaviour to adversely affect their academic achievement. The implications for future research and the limitations of the study were also discussed.


This study uses data from the National Homicide Monitoring Program within a context of national and international research to describe what is known about the trends and key characteristics of same-sex intimate partner homicide in Australia. Foreword While there is a sizable body of research on intimate partner homicide in general, there has been limited focus on intimate partner homicide involving people in same-sex relationships. The present study, one of the first of its kind, uses data from the National Homicide Monitoring Program (NHMP) within a context of national and international research to describe what is known about the trends and key characteristics of same-sex intimate partner homicide in Australia. An analysis is provided of the similarities and differences between same-sex and opposite-sex intimate partner homicide incidents, including identification of some of the factors associated with these incidents. Consideration is also given to the role of sexual discrimination and marginalisation in same-sex intimate partner homicide.


In 1999,the Second National Commission on Stratigraphy of China formally suggested that the Chinese Pliocene Epoch be divided into the early and late parts, and named them as the Gaozhuangian and Mazegouan ages, respectively. The chronostratigraphic unit Gaozhuangian Stage corresponds to the Gaozhuangian Age. The name "Gaozhuang" is derived from the lithostratigraphic unit Gaozhuang Formation, whose type section is located at Taoyang-Gaozhuang-Zhaozhuang in Yuncu Town, Yushe County, Shanxi Province. The Gaozhuangian Stage is correlated with the marine Zanclean Stage in the International Stratigraphical Chart, and they share the same definition of the lower boundary at the top of the paleomagnetic Chron C3r, with an age of 5.3 Ma. At the Taoyang section in the Yushe Basin, this boundary is situated in the basal part of massive sandstones of Bed 5 of the Gaozhuang Formation. The Gaozhuangian Age is correlated with the Ruscinian Age of the European land mammal ages, and it includes a Neogene mammal faunal unit, i.e. NMU 12, corresponding to the European MN 14—15. The Gaozhuang fauna from the Yushe Basin belongs to NMU 12. Among the Pliocene mammalian faunas in China, the Shilidun fauna from the Linxia Basin, Gansu, the Leijiahe fauna III from Lingtai, Gansu, and the Harr Obo and Bilike faunas from Huade, Inner Mongolia also belong to NMU 12. The Shilidun section of Guanghe, Gansu is a potential candidate stratotype of the Gaozhuangian Stage.


This paper presents an experimental study performed on building elements with embedded 3D thin defects looking to evaluate testing techniques used in Infrared Thermography (IRT) applications in buildings. An experimental campaign is performed on building elements with 3D defects located at different depths, using a pulse phase thermography based experimental setup. While numerous active IRT testing techniques have already been developed for Non-Destructive Testing (NDT) in many areas, there is still a substantial lack of active IRT applications in Civil Engineering due to the specific characteristics of building materials and construction solutions. This paper looks to further the application of experimental active IRT in buildings by presenting an experimental active IRT campaign which has been performed on test specimens simulating defected building elements containing thin inclusions beneath a ceramic tiling system. Test results are presented in terms of phase contrast curves.


The #metoo movement reaching academia and Applied Linguistics creates a need for discussion on how we as scholars react to oppressive ideologies and behaviors in our community. However, this is not merely a question of processing cases of sexual harassment and assault. More deeply, we need conversations on who we do and do not know, read, and cite, and how to make our field more epistemologically equitable. This article hopes to elicit comments, reactions, and dialogue.


Background  Seborrheic dermatitis is a common inflammatory skin disorder affecting 1–3% of the population. It is thought to be linked to dandruff via a common etiology, yeasts of the genus Malassezia. Ciclopirox is a broad‐spectrum, hydroxypyridone‐derived, synthetic antifungal agent with anti‐inflammatory properties.


We designed a web-based system with game-like properties that utilizes crowdsourcing to facilitate the beneficial transfer-of-knowledge to case managers (CMs) working with the homeless. This has two significant impacts: First, Portalis allows CMs to make informed decisions in managing client cases. Second, it enables individuals who would like to volunteer their services but are limited by time constraints to contribute.


Our mental representation of the egocentric space is influenced by the disproportionate sensory perception along the ventral-dorsal (i.e., front-back) axis of the body. Previous studies typically investigated the neural architectures involved in the egocentric representations within the visual field and revealed a crucial involvement of the parietal cortex and its interaction with the frontal lobe. However, neural architectures involved in the space representation behind self-body are still unclear. To address this problem, we applied both functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) to a 3D spatial-memory paradigm for human participants, in which the participants remembered a target location within (left or right) or outside (back) their visual field. Both fMRI and MEG experiments showed that the involvements of the fronto-parietal network including the frontal eye field and supplementary motor area were larger in the representations of retrieved target object within the visual field than outside. Conversely, the medial temporal lobe (MTL)-parietal network, including the right entorhinal cortex, was more involved in the target representation when the target was outside the visual field in both the experiments. In the MEG experiment, the connectivity increased in alpha-band frequency (8–13 Hz) in both fronto-parietal and MTL-parietal networks, and the preferential enhancement of the MTL-parietal network for the back preceded that of the fronto-parietal network for left/right. These findings suggest that the parietal cortex may represent whole space around self-body by coordinating the two distinct brain networks to process the egocentric spatial representation inside and outside the visual field. Significance Statement Representations of external space around self-body are necessary for coordinated actions, and our sensory-motor system is strongly biased toward processing the space in front. However, space exists behind us too. We conducted both fMRI and MEG studies and found that the parietal cortex coupled with the frontal lobe (FEF and SMA) and medial temporal lobe (MTL) represents a target inside and outside the visual field, respectively, although the target location was retrieved from short-term memory in both conditions. These results suggest that the parietal cortex may represent the whole of the present external space by interacting (alpha rhythm) with the frontal lobe for subsequent actions and the MTL to inquire the back scene.


Processing large volumes of information in real time requires large amounts of computational power, which consumes a significant amount of energy. With the rise in the amount of data produced, energy-efficient high-performance information processing systems are becoming a necessity. We present a hybrid CPU-FPGA system for high-throughput classification of streams of textual documents (e.g. emails or web pages). The current system parses the document stream using a multicore CPU and performs classification on the parsed stream using Field-Programmable Gate Arrays (FPGAs). As an example, we demonstrate a Naive Bayes classifier on the TREC Aquaint dataset. Our current solution can classify 10Gb/s internet traffic in real time. Our aim is to increase the throughput to 100Gb/s by incorporating the parser into the FPGA design.


To the Editor:We have readwith interest the article byNew et al. [1] about a family with Nijmegen Breakage Syndrome (NBS) and a novel mutation in the NBS1 gene whose affected members were misdiagnosed as Fanconi Anemia (FA) based on their increased sensitivity to DNA cross-linking agents. We report on another case of NBS and positive diepoxybutane (DEB) test. Our patient, a female diagnosed as NBS at the age of 13 years, presented with clinical, immunological, and cytogenetics features consistent with NBS. As an interesting finding, a clinically disabling juvenile rheumatoid arthritis-like polyarthritis was also part of her phenotype [2]. During follow-up, DEB test was also performed. Chromosome breakages in the patient and in the control culture were evaluated in 50 metaphases in each case (breaks/cell). Sensitivity to DEB was significantly increased in the patient (2.4 breaks/cell) versus the control (0.02 breaks/cell). Genomic DNA molecular analysis showed the common NBS1 gene mutation in homozygous state, as described in the vast majority of NBS patients. NBS and FA patients share developmental delay and microcephaly, immunodeficiency is more common in NBS, and aplastic anemia is more frequently associated with FA [3]. At least 11 complementation groups and 9 associated genes are known in FA and their products interact in the so called breast cancer susceptibility gene (FA/BRCA) pathway of genome stability and tumor suppression. On the other hand, nibrin, the mutated protein in NBS, is an essential component of the Mre11/Rad50/NBS1 complex that plays a critical role in DNA repair and chromosomal stability. More than 90% of all NBS patients carry a 5-bp deletion in exon 6 of the NBS1 gene resulting in the expression of a partially functional truncated protein. Cells from individuals with NBS are hypersensitive to ionizing radiation, whereas patients with FA are hypersensitive to DNA cross-linking agents, as Mytomycin C (MMC). and DEB. However, it has been demonstrated that NBS cell lines and individuals with NBS are also hypersensitive to MMC [4]. Different conclusions can arise from the findings in the present case. As previously stated by others authors [1,2], DEB test cannot be considered specific for FA diagnosis because other diseases, as NBS, show increased chromosomal breaks in response to it. Interestingly, DEB sensitivity does not appear to be mutationspecific for NBS, as different mutations, those leading to no protein [1] or a truncated, low level of protein, as predicted by mutation 657del5 in our patient, showed increased sensitivity to DEB. Moreover, DEB-sensitive NBS patients showed severe and debilitating immune-mediated complications suggesting that different NBS subgroups could be defined based on their DEB sensitivity.


The invention provides a multi-faceted prism ultrahigh uniform-speed scanning-based uniform-speed linear light spot optical path system. The system is composed of an off-axis parabolic mirror, an off-axis parabolic cylindrical mirror, an oblique multi-faceted prism, an oblique cylindrical parabolic mirror and an off-axis parabolic cylindrical mirror; the system is suitable for optical fiber output-class lasers with a wide power range and wide-range lasers such as CO2 lasers. With the system adopted, an elongated linear light spot of which the energy distribution is basically uniform can be obtained, the transmission directions of focusing beams being consistent, and the positions of focusing light spots being basically coplanar; the problem of the generation of a softened layer which is caused by light spot superposition in laser quenching, long interval time and extremely short cooling time can be alleviated or eliminated, and hardening strength can be ensured; the length of the obtained linear light spot can be hundreds of millimeters, and the energy distribution of the obtained linear light spot is uniform; and the scanning speed of the multi-faceted prism is ultra high. The system can be applied to high-speed large-area laser quenching, laser cladding and laser cleaning of two-dimensional planes or three-dimensional hook surfaces with focal depth ensured.


National Cancer Institute defines liquid biopsy as a test done on a sample of blood for the detection of cancer cells from a tumor that are circulating in the blood or for the detection of cell free DNA pieces from tumor cells that are in the blood. Liquid biopsies are non-invasive blood tests since circulating tumor cells (CTCs) and cell free tumor DNA (cfDNA) fragments are shed into the bloodstream or lymphatic system (Beije, et al., 2015) from existing tumors and can be detected in blood (Curigliano, 2014). The presence of CTCs can be indicative of metastatic disease (Alix-Panabieres & Pantel, 2013).


This paper is concerned with the circuit configuration and control of parallel distributed uninterruptible power supply (UPS) systems. These systems are expected to provide high quality continuous power to critical loads in the face of mains disturbances or failure. This paper discusses the system configuration issues of distributed UPS. These can be classified as online or line-interactive systems. Decentralized control without signal communication is a major requirement for distributed systems. This paper discusses the control issues which need to be addressed before distributed UPS systems can become practical.<<ETX>>


Colour is a central issue in Renato Birolli's painting and theory since it is discussed by the artist in his writings and diary's notes starting from the mid-1930s. The article highlights Delacroix, Van Gogh and Cézenne influence in Birolli's work, discussing his theory of "colour-form".


A simple lapping device is described with which long thin rods of rectangular cross section or flat plates (≥ 0.5 mm thick) of very brittle materials can successfully be prepared.


This study was performed to review the effect of treadmill exercise and sports massage on the change of serum lipids and autonomic nerve system targeting 24 overweight female college students who have BMI more than 25 kg/m². They were divided into three groups of eight members; Only treadmill exercise group(TG), treadmill exercise with sports massage group(TSG), and control group(CG). The exercises were performed 20 times and the result is as following; The change of HDL-C significantly increased after the experiment compared with before the exercise: TSG(p<.01) and TG(p<.05). The change of TC also significantly decreased after the experiment compared with before the exercise: TSG(p<.001) and TG(p<.05). The result of one-way ANOVA among the three groups is as following; HDL-C in the TSG(p<.01) and TG(p<.05) significantly increased compared with CG and TC also significantly decreased. The change of SN also significantly decreased after the experiment both in the supine; TSG(p<.001), TG(p<.01) and in the upright; TSG(p<.01), TG(p<.05) compared with before the experiment. The change of PSN also significantly increased after the experiment both in the supine and in the upright position; TSG(p<.001), TG(p<.01) compared with before the experiment. The result of one-way ANOVA among the three groups is as following; TSG and TG significantly increased(p<.05) after the experiment both in the supine and in the upright position compared with CG. There is little change in the CG after all the varied experiments compared with before the experiment. Accoring to the result of the study. it is considered that the exercise and the exercise along with the sport massage will be a good method of obesity care and the prevention of cadiovascular disease by improving the state of blood lipid and autonomic nerveous system.


China is long term pursuing benefit and fair play in the development of its regional economy.Stricted by many factors,however,benefit and fair play are always mutual contradictory and mutual resistant.Whether can we correctly handle their relations is of vital importance to the development of China's regional economy and its social and political stability.From history angel,combining with years of practice of China's regional economy before and after liberation,this paper simply analyses its experience and lesson,at the same time,puts forward several proposals to the developing orientation and measures of China's regional economy.


Rate constants for the reactions of H atoms with the methylsilanes, (CH3)4-nSiHn, n=1–3, have been measured over the temperature range 298–580 K in flash photolysis experiments in which H atoms were produced by the mercury-sensitized photolysis of H2 and monitored by Lyman-α absorption. The values obtained, for n=1–3, respectively, are given by, The results show that methyl substitution increases the reactivity of the Si–H bond towards H atom attack. Comparison is made with previously published data, and with attack by other atoms and free radicals.


ABSTRACT Metal inert gas (MIG), Tungsten INERT GAs (TIG), laser and Electron beam (EB) cladding processes are used in cladding-based Additive manufacturing (AM). Only in the case of MIG, the raw-stock is fed axially into the molten pool resulting in the omni-directional cladding. In other processes, the raw-stock is fed off-axially into the molten pool resulting in deviation in the bead geometry from its actual trajectory and varying bead cross-section along the path. As the trajectories vary widely in cladding-based AM, it is required to maintain a consistent raw-stock feeding condition (namely, front, back or sides). Therefore, an auxiliary wire orienting mechanism has been developed which can be easily retrofitted with a conventional TIG cladding torch and CNC machine. The wire orientation angle is computed on-the-fly and hence the NC programme need not provide this information. Although this implementation was demonstrated for TIG, the same methodology holds good for laser and EB too.


Economic freedom and Corruption are always important issues that governments need to control, due to their impact on the development of each country is very large, especially in developing countries. The purpose in this article is to determine the impact of economic freedom index and corruption perceptions index on corporate income tax revenue. Empirical method was employed on secondary time series data set during the period 1999-2018. Econometric tools were employed to present and analyze the collected data from concerned bodies. The results show that economic freedom index and corruption perceptions index is significantly and positively correlated with corporate income tax revenue at 1% significance level. Besides, annual rate of inflation has a negative and significant impact on corporate income tax revenue at 10% significance level.


The effects of seawater salinity,p H and diet on growth and development of the planktonic larvae in clam Modiolus modiolus were investigated in order to explore the optimum culture conditions. It was found that growth and development of the planktonic larvae were significantly affected by the 3 ecological factors( P 0. 05). The planktonic larvae had normal growth and development at a salinity of 25-30,with the optimal salinity of 30,showing stronger tolerance to high salinity than to low salinity. The suitable p H range for growth was changed from 6 to9,and the best growth and maximal survival was observed in the larvae at p H 8. In diets experiment,both the best growth and higher survival rate were found in the larvae fed the alga mixture of Isochrysis zhanjiangensis,Nitzschia closterium and Chaetoceros muelleri Lemmerman. However,the worst growth and lower survival were observed in the planktonic larvae fed single Chaetoceros muelleri Lemmerman or mixture of Chaetoceros muelleri Lemmerman with Nitzschia closterium,indicating that Isochrysis zhanjiangensis meets the nutritional requirement of the planktonic larvae for early growth and development. There were no significant differences in growth and survival in larvae fed Isochrysis zhanjiangensis and Nitzschia closterium only and the mixed microalgae containing Isochrysis zhanjiangensis( P 0. 05).


ABSTRACT This chapter discusses a report on the results of the introduction of novel teaching strategies to an otherwise rigid and nonconstructivist approach to teaching. The novel teaching strategies are aimed to foster creativity as well as independent thought in both teaching and learning among elementary school students and their teachers. As part of a larger team, the authors taught English at a summer camp in China using methods based initially on the reader's and writer's workshop approach in the United States, which, in itself, is assumed to spur the development of creative minds. Obstacles and difficulties discussed include initial resistance, tremendous need for structure on the part of the students, and lack of exposure to using independent thought. Attention is also paid to successes. Data arose from the authors' periodic reflections throughout the camp as well as on samples of student work. Student work was analyzed for skill of English use, as well as for independent and creative content. Assessment tools included a set of rubrics developed by the researchers to determine level of English proficiency and degree of creativity and independent thought contained in each assignment. Researchers initially coded assignments together to ensure interrater reliability, then coded separately; once complete, researchers met to discuss and compare coding of the data. This field-based research study could serve as a valuable beginning for further research comparing a more constructivist approach, including learning environments where students are creatively at work and teachers facilitate an environment conducive to learning through discovery, with more traditional, structured approaches, where teacher and students follow preestablished patterns for teaching and learning, which may stifle creativity and curiosity in learning.


The German Schiller Association (DSG) is a literary society that offers its community the space and conditions to mitigate that solitariness. It is an environment that we, as Early Career Researchers, aim to employ to come together, physically, in the German Literature Archive in Marbach with a conference that will represent the launch of a new network for ECRs. Our launch event will focus on reflections on solitude in theory, in literature and in philosophy, but it will also take in psychological aspects of the experience of solitude in reality.


9729 Background: to report the NCI of Milan experience on treating Peritoneal Mesothelioma (PM) with cytoreductive surgery (CRS) and intraperitoneal hyperthermic perfusion (IPHP). Secondary endpoints: 1) assessment of potential prognostic factors; 2) test of in vitro PM sensitivity to chemotherapies; 3) development of a gene therapy approach.

METHODS
Thirty eight PM patients underwent 40 consecutive procedures. Mean follow-up was 18,7 mths. 34 (89%) cases had malignant epithelioid disease. Twenty one (53%) cases received preoperative chemotherapy. The IPHP was performed with closed abdomen technique with cisplatin+mitomycin-C or cisplatin+doxorubicin through a heart-lung pump for 60 or 90 minutes at 42.5° C. Potential prognostic biological markers were evaluated on surgical 19 PM specimens. PM in vitro drug sensitivity was evaluated on primary cultures derived from surgical specimens. We established new PM cell lines for the development of a gene therapy approach, which aimed at the inhibition of cell survival factors.

RESULTS
5-year overall and progression free survivals were 70% and 49%, respectively. The operative morbidity GIII, mortality and toxicity GIII/IV rates were 20%, 0% and 10%, respectively. PM cells largely expressed anti-apototic proteins belonging to bcl-2 and IAP family; most of the cases were negative for the expression of the pro-apototic factor SMAC/diablo. Reactivation of telomerase was found in 17/19 cases, which were positive for the expression of the hTERT catalytic subunit of the enzyme. The assessment of sensitivity profile of 7 PM primary cultures to a panel of drugs found a variable response rate for the different compounds.

CONCLUSIONS
CRS+IPHP seems consistent with a potentially effective treatment for selected PM patients. Apoptosis related markers presented an apparent correlation with PM tumor cell biology, but the their prognostic significance is still undefined. Further definition of drug sensitivity profile and the development gene therapies will provide a possible biological rationale for the design of new clinical treatments. [Table: see text].


An efficient protocol for the oxidation of secondary and primary alcohols to the corresponding ketones and aldehydes and/or carboxylic acids using hydrogen peroxide as oxidant is described. A quasi-homogenous reaction system was obtained by t-butanol as solvent to achieve high yield of the product in short time.


GDP of Saudi Arabia has increased from $ 1 billion US dollar in 1972 to more than $300 billion US dollar in 2011. The increase in population from 10 million in 1950 to 28 million in 2010, urbanization represent about 80%. the country consume about 20-25% of it's own oil production about 2.5 million per/daily. This shows that the Saudi policy have given incentive to cars user for longtime and has done little to manage demand or support public transport. The main objective of this paper is place the Saudi model in public transport in the international context and to draw an international prospective of public transport policy and the rational of government intervention in transport sector. The study gives classification models which characterize the industries and form of intervention. Further more the study highlight some of the approaches which adopted by both developed and developing industry at specific time.
The Methods and models use vary from one country and this study had classified intervention in transport sector in five models which are such as models of ownership, regulation, competition, finance system and private public partnership model. In 2011 Saudi Arabia has introduce it First National Transport Strategy, which have adopted many objectives among the most is, to improve efficiency of transport sector, module environmental impact of transport sector, improves safety facilitate the movement of peoples and goods to improve economic activity (MOT 2011). This state shows that no clear objectives to improve public transport policy.


Solar activity is characterized by alternation in dynamics of parameters amplitudes of increase and decrease. The periods of increase and the periods of decrease can be allocated and generated in separate dynamic numbers. During researches of tendencies of dynamics of these numbers it has been established, that activity of amplitudes of decrease prevails of activity of amplitudes of increase.


Since 1902, when Alexes Carrel published his original technique for anastomosis of small blood vessels and transplanting visceral organs, the discipline of surgery has hungered for a definitive monograph on reconstruction by microsurgical techniques. This fine book attempts, with 65 prominent contributors in 48 chapters, to achieve such a review. The book is divided into three parts: basic science, donor composite tissue, and reconstruction. Each part has about 16 chapters, but the main portion, and the most exciting part, deals with microsurgical reconstruction at various recipient sites (head and neck, thorax and breast, upper extremity, and lower extremity). The section on basic science refreshingly reviews the anatomy and hemodynamics of microcirculation, as well as the problems of intravascular coagulation and the metabolic consequences of ischemia and hypoxia. One section attempts to explain the rationale of various experimental procedures using extremely high magnification (×5,000) microphotographs and electron micrographs (×15,000). Most of


The increased emergence of multidrug resistant bacterial strains is a continuous life-threatening global problem. The best approach to prevent the reproduction and invasion of the pathogenic bacteria is to inhibit the replication stage. The untapped molecular machinery involved in the replication is ParE subunit of topoisomerase IV. The compounds active against the ParE were chosen for the study.

To analyze the electronic parameters, chemical stability, kinetic stability, and binding modes of the compounds.

Density functional theory (DFT) and molecular electrostatic potential (MESP) calculations were computed using Jaguar with a basis set 6-31G**++ (B3LYP) in the gas phase. MD simulation was performed for the 100 ns using Desmond available in Maestro to determine the stability and to get insight into the molecular mechanism of E. coli ParE docked complexes.

From the DFT calculations, the energy gap ∆E 7.58 and 7.75 eV between the HOMO and LUMO of both the compounds P1 (4-(2-(2-(2-chloroacetamido)phenoxy)acetamido)-3-nitrobenzoic acid) and P2 (4-(2-(benzo[d]thiazol-2-ylthio)acetamido)-3-nitrobenzoic acid) explained the chemical and kinetic stability of the system. MD results demonstrated the minimum fluctuations and conformational stability of the protein structures.

The P1 and P2 compounds were chemically and kinetically stable. Further, MD results demonstrated the stability and inhibitory action of the ligands were dependent on hydrophobic, ionic and water bridges than that of hydrogen-bonding interactions.


We are being told on an almost daily basis that the European financial position is dire and that implosion is imminent. If Greece does leave the euro as predicted there will be a significant fallout for the rest of the European economy and that includes the UK. Like most surgeons, I am an optimist by nature and feel that no matter how difficult the situation our nation is strong enough to ride the storm and come out stronger. Nevertheless, we may be in for a hard time and the healthcare system will not be immune.


Abstract : Underwater welding using shielded metal arc welding (SMAW) on US Naval Vessels is very attractive because of the ability to effect repairs without costly dry dock expenses. In the past the primary problems with underwater wet weldments on steels utilizing SMAW with ferritic electrodes, were underbead cracking in the heat affected zone (HAZ), slag inclusions, oxide inclusions, and porosity. To avoid underbead cracking three weld samples were made using an austenitic nickel weld metal with an Oxylance coating at 10 feet of salt water, 25 feet of salt water, and 33 feet of salt water. A final sample was made using austenitic nickel weld metal with a Broco coating at 33 feet of salt water. Because of the ductility of the austenitic nickel weld metal no underbead cracking occurred, however porosity and high inclusion counts were found in all four samples. The average size of the inclusion increased with increasing depth. The Broco sample exhibited far greater porosity than did the 0xylance samples. This work addresses quality of the welds, mechanisms for the formation of the inclusions, and analysis of the difference between the Oxylance and Broco weld rods.


Objective
To explore the clinical effect of levodopa combined with carbidopa for children with amblyopia and the influence on their QOL score.

Methods
A total of 60 children (60 eyes) with monocular amblyopia admitted to our hospital from June, 2017 to May, 2019 were divided into a control group (30 cases and 30 eyes) and a study group (30 cases and 30 eyes) according to the random number table method. The control group were given visual stimulation, occlusion therapy, and orthodontic glasses; in addition, the study group were given levodopa and carbidopa; both groups were treated for six months. The treatment effects, corrected visual acuities, life quality, and incidences of adverse reactions were compared between these two groups.

Results
After the treatment, the effective rate was 83.33% in the study group, and was 73.33% in the control group, with no statistical difference (P>0.05). After the treatment, the corrected visual acuities of the two groups was significantly improved. After treatment, the corrected visual acuity of the study group was significantly higher than that of the control group (P 0.05).

Conclusion
Comprehensive therapy combined with levodopa and carbidopa has a good clinical effect on amblyopic children. It can not only effectively improve the children's visual function and quality of life, but also is safe and reliable.

Key words:
Levodopa; Carbidopa; Amblyopic children; Physical therapy; Quality of life


The invention provides a resistance-reducing and wearable coating used for a concrete substrate, comprising component A and component B; wherein, the component A comprises 20-40% of hydroxyl acrylic resin or hydroxyl polyester resin, 10-25% of ultra-fine graphite, 19-30% of filling material, 2-6% of auxiliary agent and 10-30% of solvent according to the weight percentage; the component B is curing agent isocyanate. After the coating is coated, the concrete substrate has the efficacy of resistance reduction and wearability, the coating is applicable to high wearable and high-compression environment, has excellent wearability, has the efficacy of reducing the resistance, is especially applicable to the coating of the sliding surface of the concrete, generates no outgrowth during the preparation process, requires no post-processing, thereby having simple and convenient process method, saving the energy resource and having low cost. After component A and component B are mixed uniformly, the coating has excellent film-forming performance at the normal temperature and has good storage stability.


1262 © 2007 The Authors JEADV 2007, 21, 1253–1302 Journal compilation © 2007 European Academy of Dermatology and Venereology We present a case of a 74-year-old woman with the KTS coexisting with BCC localized within port-wine stain on the left side of the neck (fig. 1). The nodule was hard, ulcerated, mobile over the underlying bone, measuring 1/0.8 cm, but there was no bleeding from it. There was no regional lymphadenopathy. The histological analysis of the biopsy specimen of this lesion showed adenoid BCC. The BCC was excised with margins. The coexistence of BCC and port-wine stain was first described by Scott. Until then, the relationship between vascular malformations and skin malignancies is still casual and have been described in 16 cases. The development of nodules within port-wine stain is not an infrequent occurrence in later life. They are usually benign and result from an increased number of vascular channels together with an enlargement of diameter. If the enlargement of nodule occurs the exclusion of malignancy is recommended. A true relationship between the vascular malformation and the development of skin cancer is difficult to prove. The most important risk factors are radiotherapy and sun exposure. Possible aetiologic causes of BCC or SCC also are genodermatoses, arsenic exposure, tar exposure, immunological derangement. In contrast to our patient, most described patients were male and most of them had been irradiated previously. The domination of men may be explain by women camouflaging their vascular lesions with cosmetic make-up resulting in decreased sun damage of the skin. We suspect that in our patient the chronic occupational exposure to sunlight played the significant role in BCC development. Magana-Garcia et al. suggest that the vascular changes might predispose to the development of BCC because it could sometimes develop in a nonsun-exposed port-wine stain. In summary, there is no direct evidence that patients with this type of vascular malformation are at higher risk for skin cancer. Further reports of similar cases are needed before an association between port-wine stain and BCC can be accepted as genuine.


The calculated bond lengths and vibrational frequencies of the octahedral compounds UF6, NpF6, and PuF6 from Hartree–Fock and various density functional calculations are compared. The calculations employ relativistic effective core potentials (RECPs) derived from one-component relativistic Hartree–Fock atomic wave functions. The structures and frequencies of the hexafluoride molecules were obtained using analytic gradient and second derivative techniques. Of the methods examined here the local density (SVWN) and hybrid functional (B3LYP) have the best performance in terms of the errors compared to experiment for the bond lengths and vibrational frequencies. The analytic representations of the RECPs for U, Np, and Pu are given along with Gaussian basis sets for the valence electrons of these actinide elements.


A series of papers which appeared in the September 1969 issue of the Bell System Technical Journal treated the theory of dielectric waveguides and stressed the potential use of such media for optical communication circuits.1−4 Here we report on the realization of low-loss, thin glass films which can be used for circuit fabrication. Methods of preparing planar films and waveguides having rectangular cross section are described along with the techniques used in evaluating their optical characteristics.


The fundamental goal of this research is to develop a MAGDM (Multi-Attribute Group Decision Making) problem of Medical Consumption Products. We propose TODIM–VIKOR approach in this paper, which combines the TODIM (an acronym in Portuguese for Interactive and Multi-criteria Decision-Making) and VIKOR (Vlsekriterijumska Optimizacija I Kompromisno Resenje) procedures under Fermatean fuzzy information. A new Fermatean fuzzy scoring function is presented for dealing with comparison problems. In addition, we introduce a novel entropy measure for assessing the degree of fuzziness associated with an FFS. We also offer a Jensen–Shannon divergence measure for the Fermatean Fuzzy set that can be used to compare the discrimination information of two FFSs. This suggested measure meets all mathematical standards for being considered a measure. We introduced entropy and divergence measures to determine the objective weight in the TODIM–VIKOR approach. Meanwhile, to deal with multiple attribute group decision-making, a new decision procedure based on the suggested Entropy and Jensen–Shannon divergence measure was proposed in a Fermatean Fuzzy environment. In this article, TODIM has in view to find out the overall dominance degree, and VIKOR is to determine the compromise solution. Finally, we manage a supplier selection problem to verify the performance of the suggested Fermatean fuzzy TODIM–VIKOR method by comparing the ranking solution to the rankings of existing methodologies. We investigate the reliability and effectiveness of our proposed methodology.


As a paratrooper who was in combat in WorldWar II, I saw, but fortunately did not need, the medics who ran and crawled to help the wounded under fire. I saw plenty of riflemen freeze under fire, but not one medic. Infantry war is lonely. Movies give the wrong impression with everyone huddled together under a camera's eye. Soldiers move apart in modern combat so one sheU, one grenade, one raking machine gun pass cannot wipe out a unit. Front Une medics not only heal, they pierce the loneliness of the wounded and the dying. The medics I met, however, did more to prepare me for combat than to treat me after I got there. The first infantry lesson to learn is that you are not an individual but one part of a multi-bodied military animal—and any part can be lost, like the arm of a rock crab, and the main body wul keep on moving. I began to grasp this concept at my pre-induction physical in the former CadiUac-Olds building in Boston.We aU stripped—no hospital johnnies, no shoes, no shorts, nothing, as we spent the day slowly ascending the floors of automobile ramps that circled the inside waUs of the building. Naked— shoved close together but never, ever touching—shivering, exposed, anonymous human animals we were poked, prodded, questioned, and explored. No orifice was too intimate for public examination. This is the army, son;


Worldwide, and in Jordan specifically, date palm fruit production has been steadily increasing. Recently, various dates extracts have been used functionally as antioxidants or anticancer agents. In addition, Jordanian date palm fruit of Barhi variety at two maturity stages (Rutab) and (Tamr) inhibited chemically-induced mammary cancer in animal model. The aim of this study is to strengthen the scientific evidence on the effect of dates on mammary cancer via assessing the effect of different concentrations of water extracts of three varieties of dates grown in Jordan (Barhi, Belle Huwaimil, and Medjool) at two maturity stages (Rutab and Tamr) on the viability of MCF-7 breast cancer cell line. The effects of different extracts on MCF7 inhibition/proliferation was analyzed using MTT assay. Percentage of inhibition was calculated. The most effective concentration was 100 mg/ml for all varieties. At this concentration, Medjool variety at the Tamr stage exhibited the highest inhibition. At the 12.5 and 25 mg/ml concentrations of the extracts, the most effective date palm fruit varieties were Belle Huwaimil and Barhi at the Tamr stage respectively. At lower concentrations (3.125 and 6.25 mg/ml), Medjool at the Tamr stage and Belle Huwaimil respectively were the most effective extracts were Barhi at the Tamr and Rutab stages were the least effective (P=0.000**). It is concluded that water extract of palm fruit reduced MCF-7 cell viability.


A system for controlling the use of the portable digital device (14) having a recording function or capture a voice and / or image data (12). The operation of data recording or capture function, the portable digital device is inhibited if at a particular geographic location or region (10). Also described how to control the use of portable digital device in a communication network. The method includes the steps of receiving a signal in said apparatus on said network, analyzing the signal in the device, and determining whether to control the use of the apparatus, the apparatus according to the result of said analysis and a step to control the use. The method also includes the steps of providing a list of locations where control of the application is limited, the steps of comparing the position of the list information regarding the location of the device, the position of the device to the list present If, and a step of generating a result indicating that the use of the apparatus is controlled. .FIELD 1


We report two fluorophores, N-(1-pyrenylmethyl)-1-pyrenebutanamide and N-(1-pyrenylmethyl)-1-pyreneacetamide, that exhibit temperature-dependent emission spectra over the temperature range of 20−100 °C. The fluorophores are readily synthesized via a one-pot process and can be used in dilute form (<1 μM) for measuring the temperature of various organic solvents nonintrusively. The fluorophores allow measurement of temperatures within a precision of ±1 °C and provide an internal reference signal that allows factors such as fluorophore concentration, optical path, and excitation light intensity to be ignored.


According to Abah (2007), motivation is the thoughts to do an element since element has that means to the character doing it. Also, Emma (2008) stated that for a person to be motivated, he needs to accept as true with that an act on his element need to be observed through a given outcome. Motivation has been described in phrases of ways behavior get commenced and the way its miles sustained, is directed, stopped and the way its miles sustained, is directed stopped and what form of subjective response is gift withinside the organism whilst all that is going on. This study's foundation is the relationship between motivation and productivity. The project is a laborious effort to study productivity, with Enugu State University of Science and Technology (ESUT) serving as a test group. Specifically, the research intends to isolate and analyze the motivational techniques used by the mentioned university to solicit worker cooperation. This study is descriptive in nature, and the pattern of descriptive analysis is based on answers to specific research questions formulated by the researcher.


The background and motivation for the adoption by the ACM Council on November 11, 1966, of a set of Guidelines for Professional Conduct in Information Processing are described. A brief history is given of ethical codes in other professions. Some reasons for and against adoption of ethical rules are considered, and several sections of the ACM Guidelines are analyzed. The purpose is to inform about this important aspect of our profession, as well as to stimulate thought and interest.


In our previous paper, we have proposed mutual superposition transmission (MST) for spatial multiplexing (SM) orthogonal frequency division multiplexing (OFDM) systems. In MST, two data symbols of two different subcarriers are mutually superposed on respective subcarriers after being weighted. As a result, a diversity gain is obtained without degrading the transmission speed. However, one drawback of MST is huge computational complexity of detection of the received signals. In this paper, we propose modified mutual superposition transmission (MMST) together with a two-step maximum likelihood detection (MLD) algorithm to reduce the computational complexity of the signal detection. In the proposed MMST, the superposition operation is modified so that the receiver can detect the superposed pair of symbols separately. In the proposed two-step MLD algorithm, we first detect symbols called the base layer (BL) symbols, then detect symbols called the extended layer (EL) symbols based on the detection results of the BL symbols. By dividing the MLD algorithm into two steps, the number of symbol candidates for searching can be reduced. From simulation results, we can show that the SM-MMST-OFDM system achieves almost the same packet error rate performance as the SM- MST-OFDM system while the computational complexity is reduced.


Treatments for the maxillary impacted central incisors consist of many approaches,such as resistant reducing technique,surgical exposure combined with orthodontic traction,surgical extraction.Resistant reducing technique is just suitable for the maxillary impacted incisor with normal position and having the potential of growth,and usually it can receive a good result.Surgical exposure combined with orthodontic traction is the most popularly technique used in clinic.Surgical techniques include open eruption exposure and closed eruption exposure,and the latter is better.The most important thing in the orthodontic traction is the design of anchorage,position,direction and force of the traction.Surgical extraction and other techniques are mainly used for dilacerated impacted incisors,so they are seldom used in clinic.


This paper explores the question of whether and how individuals may sustain economic cooperation absent government. To do so I present and examine a case study of EVE Online, wherein individual players seeking to fight one another in an online virtual world must nevertheless figure out how cooperate in an anarchic setting. Contrary to what some of the previous literature might suggest, I find that players effectively establish property rights and engage in contractual exchange through the combined use of a simple reputation mechanism and self-policing.


People living with HIV (PLWH) have a high risk for lymphoma, particularly non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma. The likelihood of developing NHL with severe immunosuppression is approximately 1% annually, an increase of about 100-fold compared with the general population. Even with a stable, effective antiretroviral therapy (ART) regimen, PLWH have a roughly 10-fold higher NHL risk than the general population. Non-Hodgkin lymphoma is now a leading cause of death for PLWH (1). Thus, identifying NHL-specific risk factors and interventions is a high priority for improving HIV/AIDS clinical care. A team of investigators from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) analyzed data from more than 50000 European patients to examine whether NHL risk in PLWH is further increased by co-infection with hepatitis C virus (HCV) or chronic hepatitis B virus (HBV) (2). In their analysis, the hazard ratios for NHL were 0.67 (95% CI, 0.40 to 1.12) with HCV infection and 1.33 (CI, 0.69 to 2.56) with HBV infection before ART initiation versus 1.73 (CI, 1.21 to 2.46) and 1.74 (CI, 1.08 to 2.82), respectively, during ART. Thus, these viral infections seem to be unassociated with NHL risk in the absence of ART but associated with NHL risk similar in magnitude to the estimated risk in the general population during ART (3, 4). Although this study was large and carefully conducted, there are reasons for caution in its interpretation. First, control of HIV replication with ART apparently had minimal effect on NHL risk. Incidence of NHL in the absence of HCV or HBV infection was 186 cases per 100000 person-years in ART-naive patients versus 149 cases per 100000 person-years in ART-treated patients. Incidence was actually higher in ART-treated patients than ART-naive patients among those with HCV infection, HBV infection, or dual infection. This finding runs counter to a substantial body of literature showing that HIV treatment consistently decreases risk for NHL. In particular, a previous article from COHERE reported systemic NHL incidence of 463 cases per 100000 person-years in untreated patients versus 205 cases per 100000 person-years among those receiving combination ART (rate ratio, 0.44) and primary brain lymphoma incidence of 57 versus 24 cases per 100000 person-years, respectively (rate ratio, 0.43) (5). Speculation on the reasons for this inconsistency is possible, given that the treated and untreated cohorts in the current study largely comprise the same persons who were switched after initiation of ART. However, the expected association of ART with NHL is so large that, in its absence, a superimposed effect of HCV or HBV infection becomes suspect. A second concern is the extrapolation of NHL risk estimates up to 10 years based on data for median follow-up of 13 months for untreated patients and 50 months for treated patients, with many more NHL cases indicated in the spline-based parametric cumulative incidence curves compared with the numbers actually observed among HCV- or HBV-infected patients. Because the association of ART with NHL risk was null, this extrapolation to intervals with sparse information could be problematic. Third, several previous studies of AIDS-related NHL have failed to detect increased hazard ratios for hepatitis virus co-infection. As cited by the authors, HCV infection was associated with decreased NHL risk in the Aquitaine cohort after adjustment for treatment (6). Also, HCV or HBV co-infection did not increase NHL risk in the Swiss HIV Cohort, although treatment status was not reported (7). Moreover, there was no association between HCV infection and NHL in the Chelsea and Westminster HIV cohort during the ART era (8). Finally, co-infection with HCV and HBV was not associated with hematologic cancer in patients in the Montefiore HIV cohort, 55% of whom were receiving ART (9). Although these new findings are potentially more specific for ART-treated patients, additional research is needed for confirmation. If HCV and HBV infection are actually associated with increased risk, several mechanisms could be responsible. These infections or their antiviral treatment could be immune stimulators, which contribute directly to lymphomagenesis. In patients with a low CD4 cell count, NHL arising soon after ART initiation could represent unmasking in the phenomenon known as immune reconstitution inflammatory syndrome. On the other hand, chronic HCV or HBV infection could hamper immune recovery or attenuate ART effectiveness. Hypothetically, anti-HCV or anti-HBV therapies could themselves be lymphomagenic. However, none of these potential carcinogenic effects would be important if HCV and HBV infection could be prevented or effectively treated. In fact, the main reasons to prevent and treat HCV and HBV infection are to reduce hepatic failure and hepatocellular carcinoma, which are more common sequelae of these viral infections than NHL. The ART-treated patients without HCV and HBV infection had a median CD4 count of 0.256109 cells/L at NHL diagnosis, and the counts in co-infected patients were even lower, which speaks to the need for earlier initiation of ART. Given that NHL among PLWH too often presents at a late stage, we have recently suggested that simple screening methods (physical examination, chest radiography, and serum lactate dehydrogenase measurement) might afford earlier detection of and lower mortality from lymphoma (10). In research studies of ART-naive PLWH, circulating levels of chemokines, other cytokines, micro-RNAs, and markers of microbial translocation have been predictive of AIDS lymphoma, but these parameters have not been evaluated in patients receiving effective ART or with regard to their performance in the presence of HCV or chronic HBV co-infection. The finding that NHL risk during ART is elevated 1.7-fold with HCV or HBV co-infection may partially explain the persistent excess of NHL in patients with well-controlled HIV infection. More important, this study highlights the urgent need to prevent HCV and HBV infection in PLWH and to treat those who are co-infected.


BACKGROUND
RhoA signaling is widely reported to be dysregulated in Alzheimer's disease (AD), but its therapeutic targeting demonstrated mixed outcomes. We hypothesize that the activation and inactivation states of RhoA and LIMK are different in the cortex and in subregions of hippocampus along the rostral-caudal dimensions.

OBJECTIVE
We intended to elucidate the plane and spatial dependent RhoA signaling in association with AD.

METHODS
We applied antibody pRhoA that recognizes an inactive state of RhoA (S188 phosphorylation) and antibody pLIMK against an active state of LIMK (T508 phosphorylation) to investigate RhoA signaling in wildtype (WT) and triple transgenic AD (3xTg-AD) mouse model. We prepared serial sections from the rostral to caudal coronal planes of the entire mouse brain followed by immunofluorescence staining with pRhoA and pLIMK antibodies.

RESULTS
Both pRhoA and pLIMK elicited a shift of expression pattern from rostral to caudal planes. Additionally, pRhoA demonstrated dynamic redistribution between the nucleus and cytoplasm. pLIMK did not show such nucleus and cytoplasm redistribution but the expression level was changed from rostral to caudal planes. At some planes, pRhoA showed an increasing trend in expression in the cortex but a decreasing trend in the dentate gyrus of the 3xTg-AD mouse hippocampus. pLIMK tends to decrease in the cortex but increase in the dentate gyrus of 3xTg-AD mouse hippocampus.

CONCLUSIONS
RhoA activation is dysregulated in both human and mouse AD brains, and the RhoA-LIMK signaling axis reveals spatial dysregulation along the rostral-caudal plane dimensions.


A study was undertaken to identify the potential parents and superior hybrids for yield improvement in Bhendi at the Plant Breeding Farm, Department of Genetics and Plant Breeding, Faculty of Agriculture, Annamalai University during the year 2015. The experimental material consisted of six genotypes collected from various sources representing wide genetic diversity. The selected six genotypes namely Arka Anamika, Arka Abhay, Hissar Unnat, Kamini, MDU 1 and Pusa Savani were crossed in all possible combination (diallel fashion) and produced 30 hybrids (including reciprocal crosses). The characters observed were days to 50 per cent flowering, plant height at maturity, number of branches per plant,fruit length, fruit girth, fruit weight and fruit yield per plant. Standard heterosis was computed for commercial exploitation of hybrid vigour. One of the parents Hissar Unnat, a national check variety was considered as standard variety to work standard heterosis. The hybrids selected based on the magnitude of heterosis, the hybrid Hissar Unnat  Pusa Savani possessed significant positive value for number of branches per plant, number of fruits per plant, fruit length, fruit weight and fruit yield per plant. Hissar Unnat  Pusa Savani recorded maximum negative and significant heterosis for days to 50 per cent flowering, Arka Abhay x Hissar Unnat negative and significant heterosis for plant height and Arka Anamika × MDU 1 recorded maximum negative and significant heterosis for fruit girth. These hybrids have been identified as best hybrids from the productivity point of view, further these high yielding hybrids may be tried under different environments to test their stability over locations and to confirm their superiority.


Exclusive π+π− production in proton-antiproton collisions at s=0.9 and 1.96 TeV in the Collider Detector at Fermilab has been measured. Events with exactly two particles with opposite charge, in |η(π)| < 1.3, with no other particles detected in |η(π)| < 5.9, were selected. We require the central π+π− state to have rapidity |y(ππ)| < 1. The data are expected to be dominated by double pomeron exchange. Therefore, the quantum numbers of the central state are constrained. The data show resonance structures attributed to the f0 and f2 mesons. The results are valuable for light hadron spectroscopy, and for understanding the nature of the pomeron in a region between non-perturbative and perturbative QCD.


Replacing traditional incandescent and fluorescent lights with more efficient, and longer-life LEDs is the trend in the lighting industry. However, since it is directly connected to AC line, like the traditional forerunners, there is a risk that 100Hz or 120Hz flicker could occur as a result of driving current ripple at the supply's output, which may make the consumers uncomfortable though most of the time human eyes are not able to notice them. LED and luminaire manufacturers are keen to get the problem solved, and they turned to the driver manufacturers because ultimately the driver determines whether flicker or not. This article investigates the cause of flicker, describes how it occurs to LEDs, and explains how engineers do trade-off between different solutions to solve the problems. Finally it offers a cost-effective and flexible way of implementing flicker-free LED lighting by utilizing ripple suppressor.


Objective. To identify the scientific evidence available on factors associated to the duration of exclusive breastfeeding. Methodology. A systematic review w...