Objective To design a curriculum of clinical nursing simulation training based on working process systematization theory,which will not only enhance students' clinical thinking and skills but also improve their internal nursing abilities.Methods After clinical nursing research and task analysis,20 nursing cases of training project with high degree of aggregation were selected as study environment.The training was presented with 5 steps and 9 tables in each case.Results The book of clinical nursing thinking and skills simulation training tutorial was designed.The nursing simulation training platform based on network was used as the curriculum carrier.The average score of 9 tables with 207students ranged from 53.2 to 74.1 in pre-test.The results showed a normal distribution.Both the teachers and students found the training course could significantly improve clinical nursing ability.Conclusions The clinical simulation training course based on working process systematization is an innovative course suitable for improving the abilities of vocational nursing students.

Key words:
Working process systematization; Nursing thinking; Skills; Simulation training


Current standards used to assess specific anthropometric measures (weight[W], length [L], and occipitofrontal circumference [OFC]) in infants employ the use of growth curves established by Lubchenco et al in 1967. These curves are used to classify an infant as small, appropriate, or large-for-gestational age (SGA, AGA, LGA respectively). These classifications can bear significant implications for the newborn (further work-up for SGA and LGA infants) and parents (prognosis for SGA and LGA infants). We have observed a high percentage of newborns with birthweight >4000 gms (11.8%) and >4500gms(2.8%) in our population. Our aim was to compare measurements of W, L, and OFC in a population of infants born at military hospitals (MH) with Lubchenco. W(kg), L (cm), and OFC (cm) were compiled from 6422 infants born at two MH from 1992-1995. Infants were grouped by gestational age (GA) and gender. The 10th, 25th, 50th, 75th, and 90th percentiles were calculated at each GA for all infants. 95% confidence intervals (CI) were calculated for each parameter at each GA and medians were compared to medians from Lubchenco. For W, Lubchenco medians fell outside the 95% CI for infants at 24,25, and 27 weeks and were larger than infants born at these GA at MH. For OFC, Lubchenco medians fell outside the 95% CI for infants at 29-31 weeks and were also larger than infants born at these GA at MH. For L, Lubchenco medians fell within our 95% CI up to 35 weeks. However, for W, Lubchenco medians also fell outside the 95% CI for infants at 39-42 weeks and were smaller than 39-42 week infants born at MH. For L, Lubchenco medians diverged outside our 95% CI for infants at 36-42 weeks and were smaller compared to 36-42 week infants born at MH. OFC had similar trends with Lubchenco medians falling outside our 95% CI for infants at 37-42 weeks and were also smaller compared to the similar group at MH. We conclude, in general, infants born less than 30 weeks at these MH have smaller OFC's and weigh less compared to Lubchenco, but infants near term gestation are larger in OFC, L, and W compared to previous standards. We speculate that differences in the study population, environmental factors, and maternal factors play a role in the anthropometric differences observed.


In order to study gas hydrate, potential future energy resources, Korea Institute of Geoscience and Mineral Resources has conducted seismic reflection survey in the East Sea since 1997. one of evidence for presence of gas hydrate in seismic reflection data is a bottom simulating reflector (BSR). The BSR occurs at the interface between overlaying higher velocity, hydrate-bearing sediment and underlying lower velocity, free gas-bearing sediment. That is often characterized by large reflection coefficient and reflection polarity reverse to that of seafloor reflection. In order to apply depth migration to seismic reflection data. we need high performance computers and a parallelizing technique because of huge data volume and computation. Phase shift plus interpolation (PSPI) is a useful method for migration due to less computing time and computational efficiency. PSPI is intrinsically parallelizing characteristic in the frequency domain. We conducted conventional data processing for the gas hydrate data of the Ease Sea and then applied prestack depth migration using message-passing-interface PSPI (MPI_PSPI) that was parallelized by MPI local-area-multi-computer (MPI_LAM). Velocity model was made using the stack velocities after we had picked horizons on the stack image with in-house processing tool, Geobit. We could find the BSRs on the migrated stack section were about at SP 3555-4162 and two way travel time around 2,950 ms in time domain. In depth domain such BSRs appear at 6-17 km distance and 2.1 km depth from the seafloor. Since energy concentrated subsurface was well imaged we have to choose acquisition parameters suited for transmitting seismic energy to target area.


This work is dealing with the motivation of the Vietnamese people in the Czech Republic to migration and sending the remittance. The aim of this work is to analyse the sending of the remittances of the Vietnamese people living in the Czech Republic. In this work I focused especially on what motivated Vietnamese people for migration to the Czech
Republic and to sending the remittance. The quantitative research in the form of questionnaire construction was used in research. In this research I found out that the Vietnamese people mostly migrate abroad to build the business activity so they could financially secure their families by means of the remittance. The work is solved in the context of migration and the practice of sending the remittance.


Three species of fish namely Chryschthys nigrodigitatus, Clarius anguillaris and Tilapia zilli obtained from the River Niger investigated to ascertain the extent of trace metal pollution. The fishes were cut into three parts namely, the gills, muscles and tails and were analysed for trace metals such as manganese, lead, cadmium, chromium, nickel and copper using the atomic absorption spectrophotometer of model pye unican SP 2900 Australia. The results obtained revealed that all the aforementioned trace metals were all detected and there were variations in the concentrations of metals in various fish parts analysed. There were evidence of bioaccumulation of metals in fishes indicating that they were highly polluted since the values exceeded the WHO set standard for fishes. A look at the mean results further indicated that the gills accumulate more metals than those of the muscles and tails. Also Tilapia zilli was observed to accumulate the highest trace metal levels than others in this study. Manganese had the highest concentrations when compared with other metals. The fishes studied can be used as indicators for environmental pollutions monitoring programme in Nigerian Rivers.


The discovery of new lanthanide properties in layered rare‐earth hydroxides is tremendously important to developing novel materials with the advantages of both lanthanides and layered hydroxides. Herein, a polyethylenimine‐assisted hydrothermal route for preparing Ce‐doped layered yttrium hydroxide nanoplates (LYH:Ce NPs) is established, in which the Ce doping provides simultaneous control of the size and fluorescent properties. Typically, 10% Ce doping tailors the average particle size from 680 to 196 nm and induces bright blue luminescence with a quantum efficiency of over 10.0%. Owing to the much more efficient f–d Ce3+ transition, the LYH:Ce NPs show three orders of magnitude stronger photoluminescence than LYH:Eu and LYH:Tb NPs, and exhibit the properties required to fabricate switched "on/off" optical sensors by controlling the Ce3+ ↔ Ce4+ redox couple. Furthermore, by combining the merits of the luminescence of Ce3+ dopants and anion‐exchange ability of an LYH host, the LYH:Ce NPs exhibit the properties necessary for photofunctional materials for photosensitized singlet oxygen production.


Infections with the human immunodeficiency virus (HIV) are the most serious problems worldwide. Characteristic of an extracted medicinal plant is of great therapeutic significance. Emblica officinalis Linn is a valuable natural plant used in the South East Asian traditional medicine for different infection.. In this paper, aqueous extract of Emblica officinalis was prepared by cold maceration. The obtained dried extract was subjected to in-vitro anti HIV activity using viral p-24 assay as a criteria for the detection of viral load and antioxidant activity by using Beta Carotenelinoleate oxidation model. The aqueous extract (40 mg/100 ml) showed significant reduction in viral load as compared to control titer value and showed antioxidant activity. It is contributed by Flavonoids and polyphenols constituents. The results of the present study indicating that the aqueous extract of the Emblica officinalis can be used against Human Immunodeficiency Virus type 1. Being antioxidant, it can be used to prevent neurological diseases (damage of brain cell mitochondria) by HIV.


Epidemiologically, the relevance of infection caused by hepatitis viruses is related mainly to their wide geographic distribution and the large number of infected individuals in all parts of the world. In this study, 668 residents from the islands around the Tucuruí Dam were selected. Blood samples were collected for investigation of serological markers (HBsAg, total anti‐HBc, anti‐HBS, and anti‐HCV) by enzyme immunoassays. HCV‐positive subjects were tested using RT‐PCR and RFLP for the identification of viral genotypes. Among the 668 subjects studied, 1.9% were HBsAg positive, 28% were total anti‐HBc positive, and 41.9% were anti‐HBs positive. The anti‐HBs marker alone (vaccine response) was detected in 25.7% of the volunteers. Anti‐HCV antibody was detected in 2.2% of the subjects and genotype 1 was the predominant genotype (70%). The results indicate an intermediate level of HBV and HCV endemicity in the region studied, as well as low HBV vaccination coverage. J. Med. Virol. 84:1907–1912, 2012. © 2012 Wiley Periodicals, Inc.


Language became a very essential aspect of human life as a result of the growth of a very large era at this time. Particularly in the usage of English as an international language. However, along with changes and improvements in social, cultural, and economic factors, tourism has also established the tourism sector as one of the most important factors for the global community, particularly for the people of South Nias, which still preserves and presents natural and cultural beauty that remains intact even in the midst of modernity. Of course, the existence of current tourists will elicit a favorable response. Thus, to prevent this from happening, a solution is needed, namely by providing teaching or socialization in the form of training of tour guide for the next generation. The community services program organized by Warmadewa University and Nias Raya University which aim to educate and increase the interest of the younger generation regarding the preservation of the tour guide and the awareness of tourism destination, this also has a relationship with cultural and linguistic aspects. This article used descriptive qualitative methodology to describe real-world occurrences that occur in a community. The data were gathered by observation, interviews, and documentation. As a consequence of this service, the younger generation is interested in tour guide profession in order to preserve one of the world's acknowledged of tourism in Nias Island especially for the students of English language study program at Universitas Nias Raya.


Everyone, even the most die-hard defender of the established order recognizes that we face serious social and environmental problems. The news media regularly circulate the latest figures on the latest social problems. The country with the worst pollution, highest infant mortality, lowest life expectancy, epidemic rates of drug abuse, poverty, anti-social behaviour. But the mainstream media, popular debate and elite discussion treat these at bestas a procession of seemingly unrelated and inexplicable facts and events. At worst the tendency is to suggest that whatever the problem racism, obesity, unemployment, famine, war that the people affected are in some way culpable. If in doubt, blame the victim.


Internet of Things (IoT) is a network that uses internet services and contains surrounded different objects such as mobile nodes, smart homes, smart transport system, and many other smart systems that will lead to smart internet. Also, IoT can be defined as a machine to machine (M-to-M) connection as any node connects to another node through internet and allow other nodes to connect. The main characteristics of these objects can be addressed in having physical body, having identifier, having computing and processing capabilities, linked with least one name and address, may sense physical phenomena or trigger actions. Simply, IoT has different meanings that can be summarized as combination of "sensors and actuators" or "Sensor Networks and Near Field Communication using Radio Frequency Identification Device (RFID) tags" [1]. IoT is a promising approach to construct a global network that possesses smart computing objects [2]. Smart computing objects will perceive from their environments and actuate with people or machines. However, the promising approach faces numerous challenges [3] such as:


Tea tasting is predominantly controlled by human experts known as "TEA TASTERS". Aroma, flavor, color are the major components in determining the quality of tea. In modern world the advancement of various image processing techniques with the help of PC can result as boon for tea industries because it can be successfully applied in imitating the visual perception of tea taster for determining tea quality in objective manner. The developed approach is able to analyze the generated color information from black tea liquor samples. For color analysis, Histogram based approach has been used with controlled illumination. Further color matching algorithm approves conformity with statistical results obtained. This paper describes the various components of intelligent system engineering and it is used for the color analysis of black tea. This paper emphasizes on a brief description of image capturing technique, illumination arrangement and color evaluation using L*ab color model. Abstract Tea tasting is predominantly controlled by human experts known as "TEA TASTERS". Aroma, flavor, color are the major components in determining the quality of tea. In modern world the advancement of various image processing techniques with the help of PC can result as boon for tea industries because it can be successfully applied in imitating the visual perception of tea taster for determining tea quality in objective manner. The developed approach is able to analyze the generated color information from black tea liquor samples. For color analysis, Histogram based approach has been used with controlled illumination. Further color matching algorithm approves conformity with statistical results obtained. This paper describes the various components of intelligent system engineering and it is used for the color analysis of black tea. This paper emphasizes on a brief description of image capturing technique, illumination arrangement and color evaluation using L*ab color model. I. Introduction Tea being a widely consumed beverage with an expanding worldwide market processed through a chain of processes like-plucking, CTC fermentation and drying. After processing the plucked leaf, the "made tea" is tested by an expert human panel having train sensory organ called tea taster and gradation done on the basis of appearance, taste and smell. Tea taster defines quality of tea in terms of some subjective parameters like character, body, color, pungency. This is a very tedious work as human experts are very few. Due to this, researchers looked forward and tried various models to award grading to tea samples Again in human term the human panel testing is subjective non repeatable may not be liable also as it depends on taster individual bias ,age ,mental state ,fatigue, experience etc (1). Thus the measurement of qualitative parameter is a complex problem because more than 700 hundred chemical compound contributes to the final quality of tea. Machine vision technology has been successfully applied in industrial inspection, defect identification in different processes like steal, fruits, vegetable etc. The color of tea can vary according to type of source used and it can also vary because of different wavelengths associated with different colors of tea samples (2). It is a combination of both hardware and software. This machine vision has potential to eliminate the problem in inconsistent result during the testing by a group of taster for the same coups of tea. In this paper an attempt is made to characterize tea quality based on appearance parameter like liquor, color (3). II. Stages of Black Tea Processing and chemistry behind its Color formation


We achived the photo-engraving and the test of an optical waveguide by a vortex beam in liNbO3 fibers using the photorefractive effect presents in this material.


Continuous successes in exploration demonstrate that gas resources are undoubtedly widely available on the planet. Recent gas discoveries are strewn just about everywhere, affecting all the continents, and prospects for large undiscovered structures are promising. This abundance of gas reserves and resources, combined with the obvious need for cleaner fuels, fuel a "gas rush". Indeed, benefiting in particular from its undeniable intrinsic properties, natural gas, which was never sure of a captive market, and which was actually restricted or banned in the power sector three decades ago, has proved very successful. Be it technological, economic or environmental, numerous factors have made it the fuel of choice in many key markets. Already accounting for about 24% of primary energy requirements worldwide, gas enjoys the highest growth rate and the brightest prospects, readily grabbing additional shares of the energy mix. While on the whole gas availability does not raise any doubt in the medium-to-long term, major trends in discoveries and field characteristics are very likely to strongly impact the future of gas. The overall distribution of gas reserves on the earth in particular does not harmonize with the size and growth of the regional markets. This creates growing regional imbalances between production and demand areas, at the continental scale, and even more, at the local scale of the countries. In consequence, the major industrialized countries are forced to rely increasingly on the international gas trade, just like the most advanced emerging countries of Asia and Latin America. Today, the gas industry has to evolve in a rapidly changing and competitive scene. The general trend of liberalization of energy markets is causing the breakup of the traditional industrial structures, the diversification of contractual forms, and the proliferation of players and trading flows. As bridging the distance between where gas is found and where it is needed represents one of the most important long-term challenge facing the gas industry, the search for new gas transportation economics and cost reductions accordingly remain crucial factors for the future expansion of gas.


A construction of the radioactive ion beam facility has been started at RIKEN, which is a project to construct a four-sector ring cyclotron (IRC-4) and a six-sector superconducting ring cyclotron (SRC-6), experimental storage rings (MUSES) and an experimental facility. Heavy ions are to be accelerated to energies of up to for light nuclei and for the heaviest nuclei by the SRC-6 and up to in the MUSES. Wide varieties of radioactive nuclear beams are to be supplied as secondary beams. Electrons, stable nuclei, and highly charged ions in addition to radioactive nuclei can be stored in the storage rings. The MUSES provides various collision methods, such as colliding, merging and internal target modes. A few of the new nuclear-physics opportunities are discussed briefly.


Hair follicles harbor a heterogeneous regenerative cell pool and represent a putative low-to-non-invasively available source of stem cells. We previously reported a technology for culturing human melanocytes from the hair follicle outer root sheath (ORS) for autologous pigmentation of tissue engineered skin equivalents. This study translated the ORS technology to horses. We de-veloped a culture of equine melanocytes from the ORS (eMORS) from equine forelock hair follicles cultured by means of an analogue human hair follicle-based in vitro methodology. The procedure was adjusted to equine physiology by addition of equine serum to the culture medium. The hair follicles were isolated by macerating forelock skin rests, enzymatically digested and subjected to air-medium-interface cultivation method. The procedure resulted in differentiated equine melanocytes, which exhibited typical morphology, presence of melanosomes, expression of cytoskeleton proteins vimentin, α-SMA, Sox2, S100ß and tyrosinase as well as tyrosinase activity followed by production of melanin. According to all assessed parameters, eMORS could be ranked as partially melanotic melanocytes. The results of the study offer an experimental base for further insight into hair follicle biology in equine and for comparative studies of hair follicles across different species.


The improvement of micro vision sensor is required for milli-machines and micromachines. This paper proposes a compound-eye-type micro vision sensor with simple structure for milli-machines. The sensor consists of only a photo sensor array and a cover. A prototype of the sensor is constructed. As an application of the sensor, detection of shape and motion is discussed. Experiments with the prototype show that the proposed sensor can obtain rough shape and motion, and is applicable for practical use.


Humanoid robots are becoming an important factor for the future work. Future planes are made for the use of humanoid robots for space and planetary exploration application. The development of humanoid robot to work in such environment for the purpose of human assisting is becoming highly demanded. The challenge of developing a bipedal robot to walking on other planets and moons is really high due the different in gravity compare to earth. The difference in the gravity might have a great effect on the robot locomotion. In order to know this effect some basic study needed to be conducted. This research studies the effect of different gravity on the locomotion. The approach for dealing for the different gravity is purposed in this study.


To more effectively manage walnut husk fly Rhagoletis completa (Diptera: Tephritidae), in California walnut orchards, it is important to understand the factors that affect the timing of adult emergence. In the present study, we examine the effects of incubation temperature, pre‐chill and chill durations, latitude, cultivar and size on the post‐diapause development of R. completa puparia. The lower developmental threshold, upper developmental threshold and optimal temperature for puparial development are estimated to be 4, 34 and 26.6 °C, respectively. The thermal requirement for adult emergence after 120 days of chilling is estimated to be 2024 degree days. Percentage adult emergence declines at both higher and lower incubation temperatures. Chill duration at 5 °C for diapausing puparia has a nonlinear negative effect on the thermal requirement but no effect on percentage emergence. Insufficient chilling leads to poor synchronization of adult emergence. Greater pre‐chill duration at room temperature increases the thermal requirement and slightly decreased percentage emergence. Latitude has a negative effect on the thermal requirement. Puparia from northern California black walnut (Juglans hindsii) have a slightly greater thermal requirement than puparia from cultivated walnut (Julgans regia). There is no significant difference in puparial fresh weight or mean thermal requirement between males and females, although the positive correlation between thermal requirement and puparial fresh weight is stronger for females than males. The effects of temperature and other environmental factors on the post‐diapause development of R. completa are discussed in relation to observations from other Rhagoletis species.


Hantzsch esters (1,4-dihydropyridine dicarboxylates) have become, in this century, very versatile reagents for enantioselective organic transformations. They can act as hydride transfer agents to reduce, regioselectively, a variety of multiple bonds, e.g., C=C and C=N, under mild reaction conditions. They are excellent reagents for the dearomatization of heteroaromatic substances, and participate readily in cascade processes. In the last few years, they have also become useful reagents for photoredox reactions. They can participate as sacrificial electron and hydrogen donors and when 4-alkyl or 4-acyl-substituted, they can act as alkyl or acyl radical transfer agents. These last reactions may take place in the presence or absence of a photocatalyst. This review surveys the literature published in this area in the last five years.


The credit classification of a borrower is the main method to effectively reduce the credit risk of P2P online loans. In this paper, LightGBM algorithm has the advantage in the high accuracy of data classification. Feature extraction, selection and reconstruction of the original data are performed by feature engineering. The One hot Encoding technology is used to re-encode the discretised feature indicators. Z-score data normalisation normalises the characteristics of continuous variables. Re-sort all feature indicators by contribution and perform PCA dimensionality reduction, and filter out effective feature indicators for training and testing. Finally, the problem of imbalance of samples and optimisation of model parameters is solved by ten-fold cross-validation. Result of simulation experiment shows that the LightGBM model has good stability, good fitting ability and high classification prediction accuracy.


Endoillumination for vitreoretinal surgery continues to improve with the introduction of brighter, safer light sources with color filters that may allow opportunities for better tissue visualization.


The article on sleepiness in neurology training in this issue of Neurology ® adds to what is known about lack of sleep in medical trainees.1 Lack of sleep has mostly been studied in areas of medical training other than neurology. The study by Reimann and colleagues tries to fill this gap. They looked at a group of neurology doctors-in-training, called residents. They wanted to see whether the residents showed signs of sleepiness and whether sleepiness made their thinking slower and less accurate. The study found that neurology residents were sleepy but not slow in their thinking after working for a complete day and night (on call) or after working one of a series of night shifts.

Sleepiness has long been a part of teaching people to become doctors, but now people inside and outside medicine are beginning to worry about the effects that sleepiness may have on patient and trainee safety. Sleepiness may make residents more likely to make medical mistakes.2 Sleepiness may also make residents poor drivers when they leave work to go home.3 One study found that sleepy residents were about as sharp in their thinking as people with blood alcohol levels of 0.04–0.05%.4

In this study, sleepiness was measured in residents after a day and night shift, a night shift, or a day shift using a test that looked at the size of residents' pupils. The study found that those residents who worked overnight (either an all day and night shift or a night shift only) were sleepier than …


The Er(superscript 3+), Er(superscript 3+)/Yb(superscript 3+) co-doped heavy metal oxyfluoride glasses were prepared by melting method. The thermal stability of the glasses was investigated by their DTA curves. Absorption spectra and emission spectra were measured with different concentrations of Er(superscript 3+), Er(superscript 3+)/Yb(superscript 3+) co-doped heavy metal oxyfluoride glasses. The Judd-Ofelt intensity parameters Ωt (t=2, 4, 6), oscillator strength, transition probability, fluorescence branch and radiative lifetime were determined from optical-absorption measurements. The FWHM was estimated from the fluorescence spectra, arid the spectroscopic properties on concentrations of Yb(superscript 3+) were analyzed.


The use of promotional discount on food is a phenomenon which is interesting among the business as one of the strategies of marketing. The use of the discount in the restaurant fast -food can be a stimulus to the decision of purchasing consumer. In this study using a sample of as many fast food restaurant visitors. With respondents as many as 100 respondents. Research is trying to see how large the stimulus the against making decisions purchase of the consumer in the restaurant fast -food Samarinda. Results of the study showed that variabel consumers behavior towards the discount effect significantly, whereas the relationship variable discount to the decision of buying influence positive but not significant and variable behavior of consumers against the decision of buying influence positive but not significant.


Member of Embelia is economically important medicinal plants. Embelia ribes is red listed endangered species. DNA barcodes Interspersed Transcribed Spacer (ITS), matK , rbcL, and psbA-trnH were selected for its species discrimination ability using TaxonDNA software and tree-based maximum likelihood monophyly analysis. The results showed that the species identification success rate of psbA-trnL and ITS+ psbA-trnL combination has high success rate "best match" and "best close match" functions on TaxonDNA. Among the barcodes employed, plastid psbA-trnL showed the highest success rate followed by ITS and rbcL while matK had the weak discriminating ability. In the concatenated sequences, the high discriminating rate was seen in ITS+ psbA , ITS+ matK + rbcL , and ITS+ matK + rbcL + psbA . In the tree-based analysis, disjunct distribution of the E. ribes species was observed in the ITS phylogeny. It is necessary to know the discriminatory ability of single or combinations of barcodes to detect variation at the inter and intraspecies levels.


The authors grasped the crucial points of such demographic phenomenon as population ageing and defined the most important consequences for the economy of the country on the increase in the proportion of older persons. On the one hand, population ageing is noted as Russian demographic security threat. On the other hand, the international experience of the formation of the silver industry and focused on a certain category of older citizens economy are noticed. Prospects of development of the market of services for pensioners are estimated.


: This paper develops practical recommendations for the implementation of innovative financial market instruments in Ukraine. The main areas of implementation of innovative financial market instruments are revealed. The basic assets, which require introduction of innovative tools in the domestic financial market, are determined. Recommendations on effective implementation of innovative financial market instruments are proposed. The development and implementation of innovative financial instruments will provide additional opportunities for managing financial flows and risks, reducing time and transaction costs.


Courses in clinical epidemiology usually include acquainting students with a single 2X2 table. All diagnostic test characteristics are explained using this table. This pedagogic approach may be misleading. A new didactic approach is hereby proposed, using two tables, each with specific analogous notations (uppercase and lowercase) and derived equations. This approach makes it easier to discuss the use of Bayes' Theorem and the two stages of analyses, i.e., using sensitivity to calculate predictive values. Two different types of false negative rates and false positive rates are discussed.


Simulation and bisimulation metrics for stochastic systems provide a
quantitative generalization of the classical simulation and
bisimulation relations.
These metrics capture the similarity of states with respect to
quantitative specifications written in the quantitative $\mu$-calculus
and related probabilistic logics.

We present algorithms for computing the metrics on Markov
decision processes (MDPs), turn-based stochastic games, and concurrent
games.
For turn-based games and MDPs, we provide a polynomial-time algorithm
based on linear programming
for the computation of the one-step metric distance between states.
The algorithm improves on the
previously known exponential-time algorithm based on a reduction to the theory of
reals.
We then present PSPACE algorithms for both the decision problem and the
problem of approximating the metric distance between two states,
matching the best known bound for Markov chains.
For the bisimulation kernel of the metric, which corresponds to probabilistic
bisimulation, our algorithm works in time $\calo(n^4)$ for both
turn-based games and MDPs; improving the previously best known
$\calo(n^9\cdot\log(n))$ time algorithm for MDPs.

For a concurrent game $G$, we show that computing the exact distance
between states is at least as hard as computing the value of
concurrent reachability games and
the square-root-sum problem in computational geometry.
We show that checking whether the metric distance is bounded by a
rational $r$, can be accomplished via a reduction to the theory of
real closed fields, involving a formula with three quantifier
alternations, yielding $\calo(|G|^{\calo(|G|^5)})$ time
complexity, improving the previously known reduction with
$\calo(|G|^{\calo(|G|^7)})$ time complexity.
These algorithms can be iterated to approximate the metrics using
binary search.


A number of known, and potential, New Zealand pozzolans have been examined with respect to their use in portland-pozzolan cements meeting the requirements of NZS 3123, Specification for portland-pozzolan cement (Type PP cement). The materials investigated comprised a pumicite, diatomaceous pumicites, diatomites, calcined shale, calcined clay and a pulverised-fuel ash (p.f.a.). All these materials, with suitable processing, could be used to produce portland-pozzolan cement to NZS.3123. The results of tests on these pozzolans raise doubts about the validity of the compressive strength requirements set out in the Standard. The relationship between the end-use of the portland-pozzolan cement and the properties of the pozzolan are discussed and a suggestion made for a change in the Standard.


11 history of e symptoms of the disease, especially in its later stages, require more careful study. Good work has been done on the pathology of chronic inflammation of the tubes and ovaries; but there are only a few scientific observations on chronic inflammation of the uterus, and we are bound to admit that many pathological points are not yet definitely settled. Further, the failure of many to grasp the important part that chronic uterine inflammation plays in gynaxological practice is responsible for much in the way of treatment that is illogical and pernicious. In dealing with the various kinds of cases, it will be most convenient if we reverse the order in which the infective process develops and take the more serious cases first.


The formulation of hypermultiplets that has been developed for five-dimensional matter multiplets is by dimensional reductions translated into the appropriate spinor language for six and four dimensions. We also treat the theories without actions that have the geometrical structure of hypercomplex geometry. The latter is the generalization of hyper-Kähler geometry that does not require a Hermitian metric and hence corresponds to field equations without action. The translation tables of this paper allow the direct application of superconformal tensor calculus for the hypermultiplets using the available Weyl multiplets in six and four dimensions. Furthermore, the hypermultiplets in three dimensions that result from reduction of vector multiplets in four dimensions are considered, leading to a superconformal formulation of the c-map and an expression for the main geometric quantities of the hyper-Kähler manifolds in the image of this map.


As someone who had never accepted the catechism that we lived in a secular world, it is with a wry sense of 'I told you so' that I read that we no longer do. Yet the 'post' in post-secular is a tricky little word, which is useful for public discourse because it is utterly vague. It simply means after, and so can imply anything you want it to. For some it is decidedly 'anti' and conjures up the rise of fundamentalism, while for others it indicates an emerging new kind of faith, which is deeply imprinted by the secular phase we were meant to be in before we entered the after stage whatever that means. In either case, it most assuredly is not the death knell of faith.


The date of Silvanus's election as bishop of Cirta is indicated in three sources: the "protocol of Cirta" (erroneously dated to March 4th, 303, which Augustine corrected to March 5th, 305: c. Cresc...


Harbor seals (Phoca vitulina) regularly hauled out at Yaquina Estuary only during tides lower than about +0.3 m. Few seals (and no pups) were present during the pupping season in May and June. The greatest numbers hauled out in August or September; a smaller secondary peak appeared in February in two of six years. Seal abundance was about the same from 1977-1983, with the summer maximum ranging from 40 to 72 seals. There have been many studies of harbor seals (Phoca vitulina) hauling out in the Pacific Northwest (e.g. Johnson and Jeffries 1977, Calambokidis et al. 1979, Everitt et al. 1980, Brown 1981, Graybill 1981, Brown and Mate 1983, Roffe and Mate 1984). But with the exception of Brown and Mate's 4.5-yr project these studies were brief (i.e. two years or less) or discontinuous. As a result, the yearly variation in numbers for a particular haul out site is poorly understood. The purpose of this paper is to examine the within-year and yearly variation of harbor seals at the major haul out site of Yaquina Estuary, Oregon during a 6.4-yr continuous period and to contrast the seasonality of seals at Yaquina Estuary with that of other Oregon estuaries. STUDY AREA AND METHODS The 15.8-km2 Yaquina Estuary is located on the mid-Oregon coast in Lincoln County. It is comprised of a narrow mouth, several embayment areas, and an upper estuarine channel area (Fig. 1). Low tides were divided into three categories: low-low, intermediate, and high-low. Low-low tides were +0.3 m or less above mean lower low water (MLLW, 0.0 m), intermediate low tides were between +0.3 and +0.6 m above MLLW, and high-low tides were from +0.6 to +1.4 m above MLLW. Yaquina Estuary was divided into four regions (II-V) with a fifth region (I) just outside the estuary mouth (Fig. 1). Censuses consisted of single sweeps of each region with a 20 x telescope from roadside vantage points adjacent of each region with a 20 x telescope from roadside vantage points adjacent to the estuary. There was one census per day (when wind speeds were less than about 20 km/hr) that was made within 1 hr of the time of predicted low tide. Regions I and II were censused during 22 low-low tides, 14 intermediate low tides and 28 high-low tides from April through September 1982 and April through August 1983. Region II was also censused during 28 low-low tides and 9 high-low tides from December 1976 through August 1977. Region III was censused during 170 low-low tides and 31 high-low tides from October 1980 through October 1983. Region IV was censused during 393 low-low tides from June 1977 to October 1983, and region V was censused during 118 low-low tides; both regions were also censused during 31 highlow tides. RESULTS AND DISCUSSION Haul-out sites.-There were eight sites where seals hauled out in regions I-V (Fig. 1). Five of these sites (A, B, F, G, and H) were adjacent to the main Yaquina Estuary channel. Site A was on the tip of the largest rock finger perpendicular to the south jetty west of the Highway 101 bridge, sites B and G were intertidal mudflats, site F was composed of three rocks that were only exposed during low tides and could hold 1-3 seals, and site H consisted of oyster rafts. In contrast, sites C, D, and E were on intertidal mudflats adjacent to two subtidal channels whose banks were not exposed at tide heights above about +0.3 m above MLLW. Site C was near a channel about 70 m wide that flowed 44 THE MURRELET 66:44-49 SUMMER 1985 This content downloaded from 220.127.116.11 on Wed, 31 Aug 2016 05:21:06 UTC All use subject to http://about.jstor.org/terms BAYER: HARBOR SEAL CENSUSING IN OREGON FIGURE 1. Yaquina Estuary study regions. southwest into the Yaquina channel, and sites D and E were along a separate channel about 140 m wide that also flowed southwest into the Yaquina channel. Log booms and rafts were present upstream of H but were not used by seals. Seals did not haul out evenly throughout the estuary. They never hauled out at region I. At region II, two seals were observed once at site A during only one of 31 high-low tides, and no seals were at A for any intermediate low or low-low tide counts. At region III, only one seal at a time was at site B in one of 31 high-low tide censuses and in only 4% of 170 low-low tide censuses. At region V, two seals hauled out in one of 31 highlow tide censuses, and one seal hauled out in 2% of 118 low-low tide counts. There were no intermediate low tide censuses at either region III or V. When seals hauled out at Yaquina Estuary, they usually did so at region IV, where they were observed in 73% of 393 low-low tide censuses. Prior to the second time seals were caught at C (i.e. researchers from Oregon State University captured and tagged seals there on 28 July and 22 August 1983), seals hauled out at C in 71% of 135 low-low tide counts; seals were at sites D, E, F, or G in 1% or less of these censuses. After the second tagging operation, seals were still at C in 64% of 11 censuses (which was not significantly different than before tagging, Fisher's exact test, p > 0.10), and they were not at F or G. But they hauled out significantly more often after than before the second tagging at D (i.e. in 55% of 11 counts, Fisher's exact test, p < 0.001) and E (in 18% of 11 counts, Fisher's exact test, p < 0.001). During high-low tides, five or less seals were found in this region only at site F in 13% of 31 censuses; there were no intermediate low tide censuses at region IV. Frequency of hauling out.-The frequency of seals at region IV during low-low tides changed seasonally (Table 1). They were least likely to be present during the JanuaryMarch and April-June periods, when an average of 43-47% of the counts were without 45 SUMMER 1985 This content downloaded from 18.104.22.168 on Wed, 31 Aug 2016 05:21:06 UTC All use subject to http://about.jstor.org/terms


Nowadays, company executives require relevant and accurate business information in real-time to take strategic decisions. It is also essential to have freedom to access this information anywhere and anytime. There is a real need to extend this functionality beyond the office and on the fingertips of the decision makers. Mobile tools for Business Intelligence aim to provide these features in a flexible and cost-effective manner. This paper describes a model of architecture of mobile tools for accessing decision support systems to overcome the limitations of existing mobile business intelligence tools and highlights the benefits of using mobile business applications.


Abstract A magnetically-induced Freedericksz transition was used in conjunction with capacitance techniques to determine the splay elastic constant of the 4,4′-dialkoxyphenylbenzoate monomer '5OO5rsquo; [C5H11OC6H4COOC6H4OC5H11] and its dimer. As a function of reduced temperature in the nematic phase, it was found that K 11 of the dimer is only about 20 per cent larger than that of the monomer. Moreover, the values of K 11/S 2 versus reduced temperature, where S is the scalar order parameter, are equal to within experimental noise. These results suggest that for short oligomers Meyer's entropic model for splay elasticity in polymer liquid crystals is not applicable. A lowest order correction to the entropic model is suggested, which partially accounts for excluded volume and dispersive effects.


Diseases characterized by uncontrolled overactivity of one or both facial nerves are distressing to the patient and discouraging to the physician who treats them. They include essential blepharospasm, hemifacial spasm, and selective facial tics involving one or two branches of the nerve on one side. They are usually slowly progressive and unremitting, and rarely associated with other neurologic disorders.


Commonly, Nd2-xCexCuO4 cuprates, which presumably contain impurity oxygen ions at apical sites, show a wide antiferromagnetic region (x = 0.00-0.12). However, depth-resolved muon spin rotation measurements by K. M. Kojima et al. on superconducting T'-La1.9Y0.1CuO4 (x = 0.00) thin films have revealed the absence of any long-range antiferromagnetic order [1]. Synthesis conditions as well as electronic correlations have been extensively investigated for both optimallyand under-doped RE2-xCexCuO4. We have recently demonstrated that superconductivity can be induced to as-grown Pr2CuO4 by a stringent control of growth conditions [2]. In contrast, a process commonly referred to "post-synthesis annealing" is an established route for the induction of superconductivity and elimination of defects in RE2-xCexCuO4. A much less investigated regime are over-doped RE2-xCexCuO4. Here, we aim at a detailed investigation of synthesis conditions using molecular beam epitaxy for high quality over doped Pr2-xCexCuO4 (x ≥ 0.15). It is worth being mentioned that the Ce substitution in Pr2-xCexCuO4 reduces thermodynamic constraints for the induction of superconductivity, and hence, even Pr2-xCexCuO4 films grown in a relaxed mode on SrTiO3 substrates show superconductivity in their as-grown state. This is in contrast to as-grown superconducting Pr2CuO4, where a coherent growth mode on GdScO3 substrates plays a crucial role [2]. Doping enhances the density of states at Fermi level with an increase of defect concentration, and metallic conduction is enhanced, i.e., decrease of resistivity with increase of residual resistivity ratio. [1] K. M. Kojima et al., Phys. Rev. B 89, 180508(R) (2014). [2] Y. Krockenberger et al., Appl. Phys. Express 8, 053101 (2015).


Derivation of statistical traffic data is highly dependent on the balance of detection and false alarm rates. In case false alarms have not been eliminated in the initial detection phase, they are often subsequently tracked, though, resulting in trajectories that do not match the true traffic situation. This finally leads to derivation of erroneous traffic parameters within the individual road segments. In this paper, a method is described how to eliminate false alarms by evaluating the trajectories and velocities of a tracking procedure. Basically, two types of false alarms are considered which bias the statistics of traffic data: The first type deals with redundant detections that lead to multiple trajectories biasing the statistics. The second type comprises false alarms that belong to the static background inducing zero-velocity into the statistics. We show that the presented procedure is able to increase the total correctness of detection and tracking from 65% up to 95% which allows a much more precise calculation of traffic flow parameters.


Heat stress is problematic to root growth in the production of containerized nursery plants. Container color may moderate effects of solar radiation on substrate temperatures. Studies were conducted near Manhattan, KS, to evaluate effects of con- tainer color on growth of roots and shoots in bush beans (Phaseolus vulgaris L.), red maple (Acer rubrum L.), and eastern redbud (Cercis canadensis L.). Four treatments among studies included containers colored flat and gloss white, silver, and black; a green container color treatment was added to the tree studies. Plants were grown in bark-based soil-less substrate and temperatures were measured at 5-cm depths in the south sides and centers. After 4 months, plant variables were measured. Roots were separated into three sections: core, north, and south. In the bean study, substrate temperatures at the south sideofthecontaineraveraged lowestinflatandglosswhite('36 8C)andgreatest inblack containers (50.3 8C). Root density at the south side was reduced in beans by 63% to 71% in black compared with flat and gloss white. In heat-sensitive maples, substrate tem- peratures at the south side of containers averaged up to 7.7 8C greater in black and green than in other treatments. Substrate temperatures in the center averaged 3.5 to 3.8 8C greater in black than in flat and gloss white, resulting in up to 2.5 times greater root density in flat and gloss white than in black containers. In heat-tolerant redbuds, the effectsofcontainercoloronwhole-plantgrowthwere lessevident. Datasuggestthatheat- sensitiveplantsbenefitfrombeinggrowninwhitecontainersorpaintingoutersurfacesof green and black containers white.


This paper studies protective measures and the lightning overvoltage which from high- speed railway traction substation high voltage 330 kV line side and a different feeder side. The lightning overvoltage simulation models of the traction substation have been established with ATP-EMTP; different outlet means and the distribution plan of arrester have been simulated and analyzed. The simulation results show that the lightning overvoltage of the feeder connecting the viaduct through power line is higher when the lightning strikes with different feeder connection mode; at the same time, a set of Y5W-42/120 arrester should be installed at the voltage transform of the low-voltage bus.


OBJECTIVE
To investigate the effects and mechanism of genistein on proliferation inhibition and onset of apoptosis in nasopharyngeal carcinoma cell line CNE.

METHOD
Antiproliferative effect of genistein against CNE was tested by MTT method. Apoptotic phenotype of CNE was observed by electron microscope. Cell apoptosis percentage and cell cycle phase distribution of CNE were measured by flow cytometric assay.

RESULT
A time dependent and dose dependent proliferation inhibition was demonstrated in CNE, the high potency has the obvious suppression on tumor growth function; Genistein induces nasopharyngeal cancer cell early apoptosis rate but to strengthen along with the density increase, 200 micromol/L group is highest, is 49.9%; and genistein induced a G2/ M cell cycle arrest. The characteristic morphological changes of apoptosis in CNE cells was observed after treated by genistein.

CONCLUSION
The time dependent and dose dependent proliferation inhibitory effect of genistein on nasopharyngeal cancer cells. Genistein's mechanism on suppressing effect is probably associated with inducing the cell apoptosis and intervening the cell circle of carcinoma cell. The results provide evidence for the potential usefulness of genistein in the prevention and treatment of human nasopharyngeal carcinoma.


Failure detection and isolation issues of engine speed, torque converter turbine speed, and wheel speed sensors commonly used in automotive powertrain controllers are presented in this paper. Due to the highly nonlinear nature of powertrain dynamics, constant gain extended Kalman filters are designed for use as detection filters. Then, a failure detection and isolation algorithm utilizing functionally redundant sensors is developed and applied to the powertrain problem. The developed algorithm is inherently robust to unmodeled dynamics and process noise and is effective in detecting and isolating failures of the powertrain sensors.


This essay considers practical jokes involving the animation of corpses at old-time wakes in Ireland. The seeming revival of the dead enacted in these practical jokes parodies the familiarfolkloric theme of the revival of the seemingly dead. Practical jokes fit into the format of the wake and were ways of integrating the corpse into the social scene. Further, these practical jokes typify a cultural tendency toward provocative ludic behavior. PRACTICAL JOKES INVOLVING the animation of corpses at wakes seems at first encounter to be a singularly bizarre practice, incongruous with its social context.' Such amusements, however, were congruent with the behavioral norms of wakes as they were held in Ireland through the first half of the 20th century. Furthermore, these seeming revivals of the dead quite possibly were part of a tradition of parodying the "revival of the seemingly dead" and "resurrection"-familiar themes in Irish folklore and popular culture. Moreover, these practical jokes should not be perceived as peculiar, for they exemplify aspects of Irish humor and the Irish proclivity toward provocative ludic behavior-introduced below by Brian Foley as the tendency to "create a situation." "There was all sorts of different wakes," Brian Foley recalled as we sat in the home of his father-in-law, Michael Walsh, in Kilmacthomas (Kilmac), County Waterford, one afternoon in 1992:


In the body, each base face (2) of the plate on both sides planes (E1, E2) (3) there are cutting plates (1, 1 '), the conical surface portion (4a) and side partial side (4) with the base face forms a cutting edge (5) at an acute angle (alpha) to each other, the flat surface portion of the same side (4b) is formed foundation surface on the opposite side and obtuse (beta). Cone axis located conical surface portion of the plate plane (6), extends offset parallel to the plate center axis (7) located in the same plate plane, forming a eccentric arcuate course of the cutting edge ing. In the cutting tool (17) having such a number of cutting edge plate, cutting plate provided around the range of the center line of the tool holder (16) (M) is preferably centerline (M) It is arranged offset by Φ = (5 ± 3) ° for.


"Reprinted fom the Annual report of the Chief to the Director, Dept. of Registration and Education, for the fiscal year 1946-1947."


Two types of intracellular aminopeptidase activity are present in E. coli B. One type, present in the 'soluble' fraction, is completely inactivated by chymotrypsin or trypsin; the other, in the particulate fractions ('ribosome' and 'membrane'), is resistant to these enzymes. The 'ribosomal' peptidase activity is present partially in a latent form which becomes activated on disruption of the ribosome structure. During the transition from log phase to post-log phase growth there is a progressive increase in the specific activity of the peptidase in the 'soluble' and 'membrane' fraction and a corresponding decrease in the 'ribosome' fraction.


It is well known that waveforms can be designed to maximize the SNR of objects with specific desired features. In some cases, it may be desirable to tune a waveform for different features at different angles. A MIMO radar can transmit multiple waveforms across a large span of angles. It is possible to design a MIMO radar waveform transmitted from individual elements to achieve the desired waveform parameters in the radar far field which is the superposition of all the individual element waveforms. A MIMO waveform model that calculates the Tx and Rx IPR across angle/range, based on the element waveforms transmitted can be used instead to calculate the element waveforms necessary to create the desired far-field waveform "beams". The specific waveform modulation for each Tx beam can be defined. This waveform can be "tuned" to maximize the SNR of specific features.


The article focuses on the values of the role of cybersecurity in the modern information society. To develop an effective system of interaction in the information space, there is a need to form boundaries of protection for users. The system of protection that exists in society is aimed at resolving the contradictions that arise at the level of actual confrontation and significant influence on political processes with clearly defined subjects of political activity. For the modern world, the subjects of global governance pay serious attention to the level of security of the management system in individual countries and regions, which indicates the effectiveness or imbalance in the management system. Also, the role of such an entity at the supranational level of the management system. Therefore, the chosen topic is quite relevant for the global process of interaction and taking into account the views of individual regions. In addition, effective protection of cyberspace will help reduce the level of manipulation by political actors, which will help increase the level of political culture among politicians and the level of political awareness among ordinary citizens. The article analyzes modern scientific approaches to understanding the concept of cybersecurity and cybersecurity, provides a generalized description of these concepts, identifies modern forms of security in cyberspace, analyzes the state of cybersecurity in the Ukrainian information space and defines its status as a subject of global interaction in the information space. In the political process, an integral element of interaction is the information space, as the modern platform for public relations between policy actors has been reformatted in the latest ways, and therefore the mechanisms of influencing citizens become innovative and demonstrate uncertain response from society and possible ways of political development. events. As a result, a number of mechanisms need to be put in place to protect all cyberspace users who engage in public communication on important policy issues.


Nickel is considered one of the most harmful heavy metals on human health. This experimental study was designed to investigate whether magnesium supplementation has any influence on nickel-induced toxicity in albino rats. Twenty one adult rats were divided into three groups of seven animals each group. The first group was used as a control and received saline solution. The second group was administered with nickel sulfate (2.0 mg/100 g, i.p) and the third group was given both nickel sulfate (2.0 mg/100 g, i.p.) and magnesium sulfate (300 mg/kg, i.p) simultaneously on alternate days. Body weight gain was recorded regularly. After 21 consecutive days, cellular functions were evaluated by biochemical and oxidative stress markers. The nickel sulfate-treatment decreased body weight gain in rats. Nickel treatment produced also oxidative injury characterized by an increase in glucose level, enzymes markers activities, lipid profile and total proteins and bilirubin concentrations. Simultaneously, glutathione level (GSH) and catalase activity was diminished in liver tissue. These results are further substantiated with obviously changes in hepato- histoarchithecture. However, the treatment with magnesium ameliorated the previous parameters and resulted in an improvement of the histopathological lesions. Our results suggest that magnesium supplementation may be effective in reducing nickel oxidative damage.


With the development of computer technology and network, the need for copyright protection and authentication is increasing day by day, and the information hiding technique is becoming more and more important. If we consider information hiding as communication process, neither the information sender nor the receiver is able to know all the characteristics of this communication channel due to the existence of channel error and malicious attacks. This has made the assumption of information hiding capacity more difficult and has delayed the development of information hiding. In the paper, a mathematical model for the calculation of information hiding capacity is proposed in the presence of channel error and malicious attacks. This model can avoid the effect of general attacks and errors soundly and provide a theoretic basis for information hiding. The lower and upper bound of the information hiding capacity are analyzed, and simulation results have proved this method is quite practical.


XMM-Newton is one of the most successful astronomical missions of the European Space Agency. We illustrate the impact of the mission with various scientific highlights covering a wide range of scientific fields from young stars up to cosmology.


ABSTRACT The present study investigated the protective effects of the polyphenol epicatechin on the protein structural changes, gel properties and N-nitrosodiethylamine (NDEA) formation of oxidatively stressed myofibrillar protein (MP). Results showed that oxidation treatments to MP significantly increased their carbonyl content and surface hydrophobicity as compared to the control groups (p < 0.05). Epicatechin inhibited protein carbonyl content and surface hydrophobicity, especially treated with 2 mM epicatechin. Under oxidative conditions, the fluorescence intensity of tryptophan gradually decreased with the increase of epicatechin concentrations from 0 to 2 mM. The storage modulus (G') was increased gradually after oxidation and epicatechin treatment. Epicatechin reduced the loss of P22 and water holding capacity (WHC), promoted the hydration of the proteins. Under oxidative conditions, epicatechin had a concentration dependent effect on the formation of NDEA; low concentrations of epicatechin promoted NDEA formation, while high concentrations inhibited NDEA production. In conclusion, an appropriate quantity of polyphenols can inhibit the oxidation of MP and formation of N-nitrosamines.


Severe pancreatitis may be associated with massive necrosis of the pancreas and/or retroperitoneal adipose tissue. Toxicity results from the dead tissue and secondary infection. A 45 year old patient, while fully immunosuppressed, developed this complication following cadaveric renal transplantation. He survived continued immunosuppression, 16 operative debridements of the retroperitoneum, and maintained a functioning renal transplant. In view of the previously reported high mortality rates from mild pancreatitis after transplantation, the current experience warrants further evaluation of the open method of treatment.


We have studied the structural and magneto-optical properties of postdeposition oxidized Co thin films. The oxidization process leads to the formation of a double-layered structure of fcc Co3O4 on top of metallic Co. The magneto-optical Kerr effect (MOKE), measured in the range 0.8 eV⩽EPh⩽5.5 eV reveals characteristic dependencies of the MOKE spectra on annealing temperature and time. In particular, we observe resonance-type enhancements of the Kerr effects by up to a factor of 10 compared with unannealed metallic Co. The experimental data are quantitatively reproduced by bilayer optical stack calculations.


High-pressure experiments on metallic thallium have been carried out using a diamond-anvil cell for pressures up to 32 GPa. A hexagonal close packed → face-centred cubic (f.c.c.) phase change takes place around 4 GPa. Fitting of the experimental data to the Murnaghan and Birch equations of state has been used to obtain values for the bulk moduli and their pressure derivatives for the two phases. Extrapolation of the high-pressure data for the f.c.c. phase to low pressure has been used to obtain an estimate of the pressure to about 0.23 GPa in nanosized metastable f.c.c. thallium inclusions formed in aluminium by ion implantation.


15%. At 5 years, the mortality of patients receivinginfrainguinal grafts for critical ischaemia is about 50%(13,16,17).Despite this highmortality, limb salvage remains goodafter femorotibial reconstruction in this fragile patientgroup. At 3 years, the cumulative limb salvage rate was67%.Withimprovedcase selection, the establishment of


Objective To analyze the clinical features and evaluate surgical procedures of traumatic intracranial venous sinus injury.Methods From January 2008 to December 2010,we analyzed the clinical characteristics of 22venous sinus injury patients.They were compressed with gelatine spongedirectly,and sutured,and ligated sinus,with the aid of EC glue and suspended the dura to terminate the bleeding.Results We found 12 cases of superior sagittal sinus injury,6 cases of transverse sinus injury,2 cases of sinus exchange injury,1 case of rock sinus injury,1 case of sigmoid sinus injury.19 cases needed repair sinus,and 3 cases needed sinus ligation.According to Glasgow Outcome Scale,17cases had good prognosis(GOS 4-5),4 cases poor(GOS 2-3),1 death(GOS 1).Conclusion We should use the appropriate surgical approach dealing with different types of intracranial venous sinus injury,which can achieve satisfactory therapeutic effect.

Key words:
Craniocerebral injury;  Venous sinus injury;  Emergency surgery


Abstract  A choice experiment was developed to assess how the value of the recreational sea angling experience in South West England would change as characteristics of the angling experience changed. Catch levels of anglers' favourite species are extremely important, until they reach around six fish per day, at which point anglers become satiated. Anglers are discerning about the species they catch – they would pay only a third as much for increased catches of non-favourite species than for the favourite species. Overall, increasing the size of individual fish would have a larger impact than increasing the catch per day, although this varies by species. In contrast, the presence or absence of rod or bag limits and the environmental quality of a site are only minor factors in anglers' decisions on where to fish. These results will help fisheries managers to identify their goals with respect to sea angling.


Changsha is a famous historic and cultural city.The trend of Changsha's real estate is closely linked with people.The paper analyzes the Changsha's estate from a multi angle,such as the humanity history,development characteristics and trend,in order to provide the reference for the personnel of market development and purchaser.


On the work one described chosen problems concerning of threats of the crew of the armored personnel carrier with dynamic loads during crushing the obstacle. One paid attention on the lack of regulations regulative this problems. One described the general construction, and also worked out model of the armored personnel carrier and crashed object. To the modeling one used the software LS-DYNA, using the method of finite elements. One gave also conditions for carrying out the numeric research. On the work one placed example results of numerical tests, deformations and stresses in the hull of the vehicle and in the crashed gate. One placed also example-courses of the speed and accelerations of chosen elements of the vehicle and people inside. On the basis on received results of simulation research one evidenced high level threats of the crews, liable to be effective with serious offences, particularly of the head and the spine. One qualified also directions and the range of further works targeting the improvement of the safety of the crew, in this taking into account the use of investigative dummy man. To further research one proposed models of dummy man Hybrid III, which for the necessity of taking in to consideration of additional elements of the equipment of soldiers (eg. the helmet, the weapon, the bullet-proof vest) must be however properly modified. One pointed also on the necessity of working out the additional protective devices and also formulate the methodology of the experimental research.


The influence of high frequency translational jitter in highly viscous liquids on the dipolar relaxation rate is calculated on the basis of an Einstein model. The frequency integral over the diffusional peak of the dipolar relaxation rate decreases with increasing mean squared vibrational amplitude. The results are applied to N.M.R. experiments on glycerol.


The specialty of coastal defence missile is aimed such as that system complex,technology difficulty big,dvelop time urgent,reliability require high and so on.Start with the relation of the reliability manage technology of coastal defense tactical missile and equipment system project manage,The connotation motivity and means of reliability manage were definituded.The idea of system project reliability manage and method of reliability information manage were put forward.This have importante directe effection to standard equipment develop program,in effect using test information,ensure equipment quality.


Objictive To explore the incidence of Meckel's Diverticulum(MD)coexisting with other malformations and to study the relationships among pathomorphological characteristics and complications and clinical symptoms of MD.Methods 61children with MD in our hospital from Jan,1990to Jan,2003were reviewed to analysis the pathological changes and the clinical characteristics.Results Of 61children with MD,there were other deformities in10cases(16.4%),53(86.9%)occurenced complications,55(90.2%)had clinical symptoms,26(42.6%)occurenced ectopic gastric mucosa(EGM).The hemorrhages rate of occurencing in children with EGM was significantly higher than those without EGM.Of 55cases with clinical symptoms,49(89.1%)occurenced complications,but no one had complications in the6cases without clinical symptoms.Conclusions MD might coexist with other malformations,so operation should be performed carefully to avoid missed diagrosis.In the children with MD,the EGM caused hemorrhage obviously and complications were closely related with clinical symptoms .Meckel's Diverticulum/PA


5 years"(PDat)))) AND (sensitiv*(title/abstract) OR sensi- tivity AND specificity(MeSH Terms) OR diagnos*(title/ abstract) OR diagnosis(MeSH:noexp) OR diagnostic *(MeSH:noexp) OR diagnosis, differential(MeSH:noexp) OR diagnosis(Subheading:noexp)) AND ("last 5 years"(PDat)))) NOT (((((((((((aged OR aging) AND (androgens/deficiency OR hypogonadism OR testosterone/deficiency))) AND ((health behavior OR hypogonadism/epidemiology OR impotence/diagnosis OR libido OR life Style OR Penile erection OR quality of life OR reference values OR risk OR spermatogenesis)))) AND (sensitiv*(title/abstract) OR sen- sitivity AND specificity(MeSH Terms) OR diagnos*(title/ abstract) OR diagnosis(MeSH:noexp) OR diagnostic *(MeSH:noexp) OR diagnosis, differential(MeSH:noexp) OR diagnosis(Subheading:noexp)) AND ("last 5 years"(PDat)))) OR ((((((aged OR aging) AND (ANDrogens/deficiency OR hypogonadism OR testosterone/deficiency)) AND ("last 5 years"(PDat)))) AND (((Questionnaires OR ADAM OR Smith OR AMS) AND ("last 5 years"(PDat)))) AND ("last 5 years"(PDat)))))) AND ((((((aged OR aging) AND (ANDro- gens/deficiency OR hypogonadism OR testosterone/defi- ciency)) AND ((questionnaires OR adam OR smith OR AMS OR mmas OR massachusetts male ageing study OR aging males symptoms scale) OR (health behaviOR OR hypogo- nadism/epidemiology OR impotence/diagnosis OR libido OR life style OR penile erection OR quality of life OR re- ference values OR risk OR spermatogenesis)) AND ("last 5 years"(PDat)))) AND (sensitiv*(title/abstract) OR sensi- tivity AND specificity(MeSH Terms) OR diagnos*(title/ abstract) OR diagnosis(MeSH:noexp) OR diagnostic *(MeSH:noexp) OR diagnosis, differential(MeSH:noexp) OR


Z" bosons have been produced by collisions of longitudinally polarized electrons with unpolarized positrons at the SLAC Linear Collider and their decays have been recorded by the SLD experiment. We present preliminary QCD results based on the first 6000 such decays. We find good agreement between the inclusive properties of these data and the predictions of perturbative QCD plus fragmentation models. The strong coupling, a,, has been measured by three methods: jet rates yield as(MZ) = 0.119 $0.002 (stat.) + 0.003 (exp. syst.) & 0.014 (theoK); energy-energy correlations yield a,(MZ) = 0.121 f-0.002 f 0.004 + g.Fi ; and the energy-energy correlation asymmetry gives a,(MZ) = 0.108 + 0.003 5 0.005 + $gg. INTRODUCTION THE SLD AND EVENT SELECTION The SLAC Linear Collider (SLC) produces electron-positron annihilation events at the Z0 resonance which are recorbed by the SLC Large Detector (SLD)'. The first physics run began in February 1992. SLC performance continued to improve during the run, routinely achieving Z" production rates of lo-20 per hour. By the end of August, about 12,000 Z"s had been accumulated. Approximately 6000 hadronic Z" decays were used in the analysis presented here. The detector is described in detail elsewhere'. The micro-vertex and Cherenkov Ring lmaging Detectors were not used in this analysis, but are described in separate contributions to this conference3. A major achievement of the 1992 run was the delivery of an intense beam of longitudinally polarized electrons. Details of the polarization program and a preliminary measurement of the left-right cross section asymmetry were contributed separately to this conference*. In this paper we study in detail the structure of hadronic Z" decays, compare with the predictions of perturbative QCD plus fragmentation models, and measure the strong coupling, as, by three established techniques. Charged particles were tracked in the Central Drift Chamber (CDC), which consists of 80 layers of axial or stereo sense wires, contained in a 0.6T axial magnetic field. Particle energies were measured in the Liquid Argon Calorimeter (LAC) and Warm Iron Calorimeter, which are segmented into approximately 40,000 projective towers. Two triggers were used for hadronic events, one requiring a total LAC energy greater than 8 GeV, the other requiring at least two well-separated tracks in the CDC. Events were then required to pass two loose selections of hadronic events, one based on the topology of energy deposition in the LAC, the other on the number and topology of charged tracks in the CDC. tWork supported in part by Department of Energy, contract DE-AC03-76SF005 15. The analysis presented here used charged tracks measured in the CDC. A set of cuts was applied to select well-measured tracks and events well-contained within the detector accepPresented at the XXVI International Conference on High Energy Physics (ICHEP 92) Dallas, Texas, August 6-12, I992 tance. Tracks were required to have: l -afitqualityof @-Jv< 15, l a closest approach to the beam axis within 10 cm, and within 20 cm along the axis of the nominal interaction point, _ l a polar angle, 8, with respect to the beam _ _ _ .aXis within lcosel < 0.8, and l a minimum momentum transverse to the beam axis of pl> 150 MeV/c. Events were required to have: l a minimum of five such tracks, l no track with measured momentum, p > 100 GeVlc, l a thrust axis with polar angle, f3T, with respect to the beam within Icos~Tl < 0.71, and l a minimum charged visible energy, Evis > 0.2M~, where all tracks were assigned the charged pion mass. A total of 3837 events survived these cuts. The background is dominated by an estimated contribution of c 0.5% from tau pair events. HADRONIC EVENT PROPERTIES We have studied global event variables, including thrust, oblateness, sphericity and aplanarity, as well as inclusive track variables, such as rapidity, momentum, and transverse momentum in and out of the event plane. In addition, we have selected a sample of 3-jet events using a ycut (see below) of 0.02, in order to examine the scaled jet energies and the polar angles of the most energetic jet and the event plane, as well as the Ellis-Karliner angle'. For each of these quantities, we compared the distributions from the data with the predictions of two perturbative QCD plus fragmentation Monte Carlo programs, JETSET 6.35 and HERWIG 5.36. For JETSET, we used a parameter set tuned by TASS07 at & = 35GeV. For HERWIG, we used the default parameters. For each model, 10,000 events were generated and passed through a detailed simulation of the SLD and the same reconstruction, event selection, and analysis as the data. For all variables studied, both models give a good description of the data. The distributions of thrust, oblateness, and transverse momentum in and out of the event plane are shown in Fig. 1 as examples. These results confirm predictions' . of the JETSET simulation made before data at the Z" were available, and are in agreement with results from experiments at LEP9.


University of Tampere School of Social Sciences and Humanities PETTINEN, KARITA: The significance of social work in a psychiatric hospital according to patients' interwievs and medical reports Master's Thesis, 72 pages, 5 appendix pages Social Work Supervisor: Suvi Raitakari May 2016 ________________________________________________________________________________ This master's thesis studies how social work gains its significance in a psychiatric hospital. The research material in this study consist of two interwievs of patients who have been discharged from the psychiatric hospital and of the medical reports made by social workers relate to the patients taking part in the interviews. The significance of social work relate to what social work is, what patients feel beneficial in social work and how social work has influenced them or if it has influenced at all. The social workers documents are studied how social workers document their work and how it has been made. The starting point is that what social workers document is, on their opinion, significant social work for the patients. The research questions are: How do the patients give significance to the social work in their interviews? How do the social workers give significance to their work according to the medical reports? and What do the different meanings of social work tell about its influences? The patients who took part in the study were selected via the social workers in the hospital ́s acute psychiatric unit. The criterion was that the patients were in hospital care due to mental health and/or drug problem and they had been transacted with the social worker in the acute psychiatric unit. The patients were interviewed three months after the hospital care was finished, the interview material was collected by a thematic interview and those were arranged as individual interviews. The medical reports regarding the social work were used as the second material in the study. The material was analyzed utilizing thematic analysis in two different analyze sections. The significance of social work according to patients ́ interviews are analyzed in the first section. In the second section, the significance of social work is analyzed according to the documents made by social workers. The theoretical framework in this study consists of the definiton of sosial workers job description and previous knowledge about the operational environment of social work. Based on the results, social work is significant according to the patients ́ interviews and the social workers ́ documents. The patients find social work helpful towards their recovery and as a link among several different authorities at which time social work gains its significance as a sharing of information. According to the social workers ́ documents, social work is significant when defining the patients ́overall situation and as social works ́ responsibility of patients situations as well as giving the patients the responsibility of their management and arrangement of life.


Based on the daily temperature data during 1960~2008 in Xuzhou,the variation characteristics and trends of the average temperature,the extreme (minimum and maximum) temperature,cold accumulated temperature and hot accumulated temperature are discussed. The results show that,in recent 49 years,the variation trend of average temperature is upwards obviously,mainly in winter and spring (especially in February and April). The most significant warming up about 1.5 ℃ was in winter. The yearly minimum temperature and cold accumulated temperature tend upwards remarkably,and the yearly maximum temperature and hot accumulated temperature tend downwards slightly. In Xuzhou,the cold winters were focused on the former period before 1980s and the warm winters were frequently appeared after 1990s. Almost no abnormal hot summer appears in recent semicentury. So,in Xuzhou,the whole summer temperature was in the low state relatively.


Abstract Temperature-dependent FT-IR and FT-Raman studies of C60 and C70 in crystal and KBr disk states suggest that both C60 and C70 enlarge significantly with temperarture increase in the 303-523 K.


Recently developed techniques for the symbolic derivation of formulas and the automatic generation of code for numerical computation are applied to formulate the hybrid mixed model in finite element analysis. The hybrid mixed model is a promising approach to overcome several difficulties associated with the more traditional displacement models for the analysis of "constrained-media" problems. Applying the FINGER (FINite element GEneratoR) system, FORTRAN code has been generated for computing the strain-displacement coefficients and the stiffness coefficients for a sample hybrid mixed plate bending element. Attention is paid to improving the efficiency of code generated and the generality of the approach. Described is the first full-scale problem which subject the approach to stringent conditions and requirements of an actual engineering application.


Background: LADIES TRIAL is considered one of the most important trials related to diverticular peritonitis. Its protocol and results were published in 2010, 2015, 2017, and 2019. Despite this one and other published trials, the proper procedures for each diverticular peritonitis scenario are still being debated, a thorough review of the methodology used in this trial is necessary to validate or reject their conclusions.Aim: To analyze the methodology used in the design, application, analysis of results, and conclusions of all LADIES TRIAL publications. Secondly, to collaborate in the improvement of the research about diverticular peritonitis and to facilitate its analysis by the readers.Methods: The central parts of a research trial were analyzed, from the research question, hypothesis development, operationalization of variables and trial design, statistical analysis of results, to conclusions. Errors, biases and weaknesses were searched for to try and challenge the trial's findings.Results: LADIES was a randomized, open-label, superiority trial analyzed according to intention to treat modified in cases of non-compliance with the inclusion-exclusion criteria. Its design was generally correct, although errors, weaknesses, and biases were detected in its application. Regarding results, LOLA showed that, in Hinchey 3, laparoscopic lavage has a higher rate in early morbidity and mortality than sigmoidectomy, but with a shorter operative time. For its part, DIVA showed that, in Hinchey 3 and 4, the primary anastomosis has higher ostomy-free survival with less morbidity, combining the initial surgery and ostomy closure, compared to the Hartmann procedure.Conclusions: Not having reached the sample size calculated in its design implies that only large effect differences achieved statistical significance. The low frequencies of adverse events accentuated this methodological problem. The specialization of the intervening centers and surgeons, the exclusion of hemodynamically unstable patients or patients undergoing steroid therapy, compromised the external validation of their findings.


This special issue of Vulnerable Children and Youth Studies includes several papers from Eastern and Southern Africa presented at the 8th AIDS Impact Conference held in Marseilles (France) in July, 2007. The Conference is an important international event focused specifically on the 'human, economic and social sciences applied to HIV and AIDS'. In the decade following the first AIDS Impact Conference in 1991, recognition has grown of the contribution that social science research brings to our understanding of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) from a cultural, economic, medical, psychological and social perspective. A particular focus of the 2007 AIDS Impact Conference – with its thought-provoking theme 'if not now, then when' – was to highlight the interrelatedness of the biological, psychological and social aspects of HIV and AIDS and to encourage researchers and practitioners from a variety of continents, disciplines, sectors and cultures to engage in dialogue and debate over the application of human, economic and social science research – as well as its current and future role in the fight against HIV and AIDS. Given this background, and considering that in no other place in the world are young people as severely affected by HIV and AIDS as in sub-Saharan Africa, it is appropriate to focus this special issue upon child and youth vulnerabilities. The issue contains several papers from the continent highlighting opportunities for turning the tide on HIV and AIDS in Africa through harnessing particular leverage points in our preventative and behavioural intervention efforts. A companion special edition of the journal AIDS Care presents a collection of papers from the Conference exploring emerging social science research focused on antiretroviral treatment (Moatti & Spire, 2008). The 2007 Conference, and this special issue, draws our attention to a few important issues at this juncture in the epidemic. First, HIV and AIDS is often headlined dramatically by donor and international aid agencies in an effort to generate further investments which aim to change


There are many forms of life in the waterfront(especially,in the coastline),which contains rich ecological relations and implications.These forms of life can influence the life and existence of human like art.However,like Turkey,some modified projects of waterfront and/or coastline create a hierarchical,operational and exploitative relationship of man to nature,so as to seriously destroy the ecological condition of the zone,for example,abundant plants disappear,the environment is polluted,its interests of life and aesthetic values no longer exist.Although some artists try to protect the waterfront by their arts,some plants have been replanted back to the zone,it is necessary to preserve the natural qualities of the waterfront for its environmental beauty.


This paper introduces compact band-stop filters using interdigital DGS slots. The slots are etched in the ground under the 50-ohm microstrip transmission line. The two filters were realized by etching two and three slots. Both filters have lower cut-off frequency at about 4.6 GHz, and higher cut-off frequency of 7.2 GHz. A good agreement was achieved between the simulated and measured results.


With the serious shortage and increasingly high price of oil resource,the exploitation of ocean recourses become more and more important and the requirement of offshore platform steels is increased.In this paper,the classification,application and production state of offshore platform steels are introduced.And the tendency of offshore platform steels,such as the increased requirement of strength from 355 MPa and 420 MPa to 500 MPa,the demands of large thickness,-60 ℃ low-temperature toughness and improved corrosion resistance in seawater,is pointed out.


We present results of a numerical study of a Langevin equation describing the growth of wetting layers that occur when a binary mixture phase separates in the presence of a wall that attracts one of the two components of the mixture. We focus on the asymptotic behavior of the layer thickness with time and compare our results with recent theoretical predictions, showing good qualitative agreement. We also formulate and check a scaling hypothesis for the time evolution of the density-profile function.


Diffuse large B‐cell lymphoma (DLBCL) is a non‐Hodgkin lymphoma with high mortality rates. Small nucleolar RNAs (snoRNAs) are tumor‐specific biological markers, but there are few studies on the role of snoRNAs in DLBCL.


The invention discloses a power line communication channel estimation method. The power line communication channel estimation method comprises the steps of receiving signal conversion; selecting pilot frequency; conducting estimation by using a compressed sensing signal recovery algorithm. Aiming at the disadvantages that the channel estimation performance of the traditional estimation algorithm based on a least square method and a minimum mean square error is reduced with pilot frequency number, the estimation accuracy is reduced, the calculation complexity is high and the like, power line channel estimation is conducted by using the feature that power line channels have sparsity and by adopting a compressed sensing method, unit impulse responses of the channels are obtained through the known pilot frequency information by using a matching tracking algorithm, the pilot frequency number is reduced, the calculation complexity is decreased and the transmission efficiency and communication quality are improved. By adopting irregular pilot frequency distribution and designing pilot frequency distribution according to channel and noise conditions, a typical strategy is to interpose pilot frequency reference information at frequency points with small channel attenuation or larger signal-to-noise ratio to improve the accuracy of channel estimation.


Steroid receptor coactivator-3 (SRC-3) mediates the transcriptional functions of nuclear receptors and other transcription factors, regulating the cell proliferation, survival and growth. SRC-3 amplification or overexpression, detected in many hormone-dependent or -independent tumors, has been demonstrated its important role in promoting carcinogenesis. It was suggested that development of an effective SRC-3 inhibitor could offer a promising therapeutic strategy. Gambogic acid (GA), the major active ingredient in gamboges, is secreted from Garcinia hanburyi. In recent decades, accumulating evidence has been discovered to elucidate its potent anti-tumor efficacies. In our study, we investigated the effects and molecular mechanisms of GA on non-Hodgkin9s lymphoma (NHL) cell lines. GA was demonstrated to induce cell growth inhibition, G1 phase cell cycle arrest and apoptosis in NHL. The IC 50 for Daudi or Raji at 24 h was 0.15±0.01 μΜ or 0.79±0.23 μΜ, respectively. In control, the IC 50 for Jurkat or normal human lymphocytes was 1.324±0.02 μΜ or 2.54±0.21 μΜ, respectively. After incubation with 0.2 μΜ GA for 12 h, the rate of Daudi cells in G1 phase increased from 33.8±1.83% to 64.4±4.4%, with rate of S phase from 53.0±0.14% to 17.99±3.87%. For Raji cells (0.6 μΜ for 12 h), the rate of cells in G1 phase increased from 44.34±1.55% to 57.07±0.5%, with rate of S phase from 44.75±2.2% to 38.16±0.87%. The G1 phase cell cycle arrest was accompanied by the down-regulation of cyclin D3 and p-Rb and up-regulation of P21 and P27. GA (0.2 μΜ for 24 h) greatly induced apoptosis in Daudi cells (from 6.2±2.8% to 46.8±3.2%), but almost none in Raji cells (from 9.5±0.5% to 9±0.72%). When treated with 0.4 μΜ or 0.6 μΜ GA, the rate of apoptosis in Raji cells increased to 40.5±5.5% or 76.5±4.5%. The apoptosis was further confirmed by evaluating the activation of caspase3 with western blot assay. After GA treatment, cyto C and Apaf-1 increased, and Bcl-2 decreased, all indicating GA induced apoptosis in mitochondrial pathway. The effects of GA on the regulations of five oncoproteins (Bcl-6, c-Myc, NF-κB, SRC-3 and Bcl-2) were measured by western blot analysis. These oncoproteins have been considered to be strongly implicated in B-cell lymphomagenesis. SRC-3, Bcl-2 and c-Myc were down-regulated. NF-κB was down-regulated directly or inhibited via up-regulation of IκB-α. The effects of GA on Bcl-6 were contradictory in Daudi and Raji. Because of the pivotal role of SRC-3 in promoting carcinogenesis, we explored whether the above effects of GA were mainly mediated by the regulation of SRC-3. Western blot analysis showed an obvious down-regulation of SRC-3 while the mRNA levels measured by RT-PCR analysis had no marked decline. SRC-3 protein stability examined by cycloheximide assay showed an accelerated degradation of SRC-3. Since SRC-3 has been reported to be degraded in proteasome pathway, we doubted whether SRC-3 was degraded similarly in response to GA. Cullin3, the component of the ubiquitin E3 ligase for SRC-3, was demonstrated to be up-regulated. The proteasome inhibitor MG132 could weaken GA-induced SRC-3 degradation. SRC-3 was shown to be ubiquitinated with immunoprecipitation method, and the ubiquitinated SRC-3 accumulated in the presence of MG132. All the data suggested that GA induced down-regulation of SRC-3 mainly through ubiquitin-dependent proteasome degradation pathway mediated by cullin3. According to GA-induced apoptosis in five cell lines (Daudi, Raji, Pfeiffer, SU-DHL6 and Jurkat), cells with higher SRC-3 level were observed the higher sensitivity. To figure out the relationship of SRC-3 level and cell sensitivity, stable cell clones expressing lower SRC-3 by lentiviral shRNA transfection was established. We compared the antitumor efficacies of GA in SRC-3 siRNA clones with control clones. After treated with 0.6 μΜ GA for 24 h, the rate of apoptosis in SRC-3 siRNA clones or control clones increased from 14.6±3.3% to 44.3±3.7% or from 16.6±2.24% to 63.6±1.99%, respectively (44.3±3.7% vs. 63.6±1.99%, P Taken together, our results demonstrated the potent antitumor efficacies of GA on NHL and revealed that SRC-3 ubiquitination, mediated by Cullin3, played a critical role in this process, providing the molecular basis for the clinical trial in lymphoma. Disclosures No relevant conflicts of interest to declare.


The surface acidity and basicity of binary oxides of Zr with Ce and La are determined using a series of Hammet indicators and H o , ,max values are reported. The generation of new acid sites habe been ascribed to the charge imbalance of M 1 -O-M 2 bonds, where M 1 and M 2 are metal atoms. Both Bronsted and Lewis acid sites contribute to the acidity of the oxides


We report a surface spectroscopy investigation of metathesis reactions among propene, ethene, 1-butene, 1,3-butadiene, norbornene, and cyclopentylidene on a planar polycrystalline β-Mo2C surface. Surface cyclopentylidene was prepared by exposure of the clean metal carbide to cyclopentanone. Propagator species, surface methylidene, ethylidene, propylidene, propylidiene, and ring-opened norbornene were detected using reflectance absorbance infrared spectroscopy. High-resolution X-ray photoelectron data were obtained for the interaction between propene and surface cyclopentylidene. Vibrational and thermal desorption measurements as a function of the number of exposure cycles were carried out for the reaction with propene. Turnover to yield butene was detected. The carbonyl bond dissociative adsorption of propanal and acrolein was used to prepare propylidene and propylidiene to further identify the metathesis propagator species. Given that molybdenum carbide displays metallic conductance, olefin metathesis at...


Youth suicide robs a people of its dreams, its investment in the future, and its hope of passing the culture on to future generations. Although much research work has been done, the problem continues unabated. The purpose of this paper is to provide a review of research concerning suicide among native North American youth and to recommend a prevention research agenda to address gaps in knowledge. The paper is divided into three sections. The first section focuses on suicide rates by ethnicity, gender, and region. Risk factors are considered in the second section, with particular attention given to individual, family, tribal, and community factors. Finally, I highlight unanswered questions and propose a research agenda.


The problem of pattern recognition in real time applications and its performance improvement in learning system is focused in this paper. The efficiency of learning systems for pattern recognition is improved by the integration of frequency resolution information with the extension of the conventional radial network. The extended neuro modeling with radial network and with the incorporation of frequency feature is observed to provide better accuracy in estimation than the conventional RBFneuro modeling. A comparative evaluation is carried out for the retrieval accuracy for the developed recognition system and is evaluated for the Precision Recall rate for the pattern recognition system. Keyword: frequency spectral estimation, extended radial network, neuro modeling, pattern recognition


Research purposes: For the connections between the concrete beam and the steel beam of the all existing hybrid bridges around the world,the steel-concrete connective segment are specially designed as the transit connection.The structure of the steel concrete connective segment varies significantly among the different bridges.At present,there are still some critical problems to be solved in the area of how to ensure the rationality,safety and reliability of the connection structure and in the areas of the mechanical behaviours,design theory and the calculation method for the steel-concrete connection segment. Research conclusions:Under the effect of the axial compressive loading,the loads beared by the shear connector and the core concrete are proportional to their stiffness.The simulation calculation of the steel-concrete segment should be made according to the different simulation calculation purposes,and by using different models,such as the spring model,the solid model without bond-slip effects and the solid model on considering the failure of concrete with bond-slip effects.This paper presents a novel method for the connection between concrete beam and steel beam,that is to anchor the longitudinal steel bars directly on the end of the bearing plate without the joint segment.This connection structure is simple with the clear load bearing.


The digital economy is in full swing and has become a new path for economic growth, with the role of the digital economy radiating more and more widely and with greater and greater influence, and which is an important cornerstone for promoting the "Digital China" strategy, and an increasingly important driver and new path for global economic recovery and social progress. Based on relevant domestic research results, this paper collates the connections among digital economy, industrial development and economic growth, and further points out the breakthrough points for future research.