Abstract In Bangladesh, pneumonia is a major cause of child mortality, killed 26,766 under 5 children, accounting for 24% of all under 5 child deaths in 2022. To address this issue, we implemented a community-based project in Barishal from June 2021 to December 2022. Project activities aimed to strengthen the health system for improved access and utilization of quality child health care and child immunization services, encouraged community practice and behavior for care-seeking and exclusive breastfeeding. During the project period, 22 medical doctors, 30 paramedics and 168 MoHFW employed service providers including community clinics, community-based health facility for six thousand population, received case management training, 38 health centers were equipped with necessary logistics and supplies for improved case management of sick children. We also conducted special vaccination campaigns in 13 hard-to-reach areas, deployed 11 vaccination aids for improving child vaccination coverage in remote areas and raised awareness of recommended health practices at the community level. A comparison of baseline and endline survey data showed significant improvements in children among 12-23 months of age who received all recommended basic vaccines by 12 months [77% in baseline (n = 239) vs. 92% in endline (n = 235); p < 0.01]; care-seeking from health facilities or trained health service providers for sick children with pneumonia [40% in baseline (n = 127) vs. 52% in endline (n = 225); p < 0.005]; and exclusive breastfeeding for children below 6 months [52% in baseline (n = 122) vs. 62% in endline (n = 120); p < 0.01]. These results revealed the project's success with simple but contextualized efforts to enhance the health system by developing the capacity and skills of service providers to provide high-quality child health care for sick children, improving access to equitable child immunization, and raising social awareness through partnerships with the MoHFW and community engagement initiatives. Key messages • Community-based intervention with minimum resources have potential to scale up with improving accessibility and utilization of health services, specially in hard to reach areas in Bangladesh. • Contextualized and simple intervention through collaboration with local government and community engagement is critical for success of community based health system strengthening project.


Single-phase limited cubic solid solutions Pb1-xAgxS based on PbS with a metal sublattice alloyed with silver are obtained. The maximum relative content of silver in solid solutions Pb1-xAgxS reaches x = 0.15. For the first time the thermal expansion of semiconductor solid solutions Pb1-xAgxS was measured by dilatometry method in the temperature range 295-580 K. Substitution of lead atoms by silver atoms in Pb1-xAgxS leads to a decrease in the coefficient of thermal expansion associated with a change in the anharmonicity of atomic vibrations and a weak increase in the elastic properties. For single-crystal particles PbS and solid solutions Pb1-xAgxS, spatial distributions of the elastic modulus E, Poisson's ratio , and linear compressibility  as a function of the direction (hkl) are found. The reflection spectra of the synthesized powders PbS, Ag2S and Pb1-xAgxS are measured and it is shown that the replacement of lead with silver in PbS is accompanied by an increase in the width of the band gap.


Low emission swirlers for industrial gas turbine combustor are developed. Swirler designs are examined by RANS and LES simulation. Natural gas burning tests are carried out at atmospheric test rig. At design condition, low NOx and CO emission were achieved. Normalized equivalence ratio of blow off was about 0.7.


Fiber-Optic Sensors appear suitable for successfully fulfilling a wide spectrum of sensing transducer requirements in industrial and military applications. Before they supercede existing sensors, a large amount of materials, subsystem and system design research must be accomplished to solve the apparent difficulties. This paper summarizes their promise, the technological problems that arise, and the principle approaches that will solve these problems.


In this paper, an adaptive background modeling approach for moving object detection is proposed. Based on mixture Gaussian model suggested by Stauffer, a mixture Gaussians model has been built for each pixel and its learning rate can be adjusted dynamically according to the scene change from the frame difference. This approach has changed the strategy used in various improvements to re-initialize the model on the condition of light suddenly change. Experiments show that the adaptive background model proposed in this paper has good adaptability to complex environments, the convergence rate of the model can be speeded up, and the moving object can be detected effectively and rapidly in the case of light suddenly changing.


The thigh muscles of two patients with dermatomyositis (DM) without muscle weakness or conspicuous creatine kinase elevations were studied by magnetic resonance imaging (MRI). Myositis limited to the vastus intermedius muscles (VIM) was detected in both patients, and in one, the diagnosis was confirmed by the findings of a biopsy specimen. Focal myositis of the VIM in early-stage DM, which otherwise would remain hidden by the relatively small muscle size and deep location, can be detected by MRI.


Abstract : The purpose of this program was to identify, develop and characterize coating compositions, processing techniques and resulting properties for: (1) repair of localized damage to diffused aluminide coatings on nickel base turbine blade alloys and (2) re-application of coatings to worn turbine blades during engine overhaul (reprocess coating). A multiphased effort was undertaken to develop a stripping procedure for removing used aluminide coatings and a coating process for re-applying a new coating as well as for use as a repair. A comprehensive test program was also conducted to compare the environmental performance of reprocess and repair coatings and to evaluate the effects of the new coatings on the mechanical properties of the substrate relative to the corresponding properties of the original coatings. A chemical stripping procedure was developed for removing remnant Jo-Coat from B-1900 and INCO-713C and CODEP C-2 from IN-100 and U-500 without significant substrate attack. Grit blasting was found to be satisfactory for partial stripping wherein only surface scale and oxides required removal. A vacuum fired slurry slip pack coating process using 56Cr-44A1 powder as a source material was developed which was capable of affecting both complete recoatings as well as repair coatings to locally damaged areas.


Objectives: We have conducted this study to assess (1) the existence of prevention programmes for AR as developed by professional and health care organizations in AsiaPacific countries; (2) any discrepancies in local guidelines in comparison to ARIA, or within and across these countries. Study design: Web search study. Methodology: We have conducted a study using Web search in accordance with the perspective of physicians or patients for the relevant prevention and pharmacotherapy guidelines in the management of AR as developed by professional and health care organizations in Asia-Pacific countries/regions. Results: National allergy (AR and/or asthma) preventive programs are found in only 6 out of 17 (22.2%) countries (excluding Japan and South Korea). There exist several aspects of discrepancies in existing educational programs such as in (1) allergic disease (asthma or AR) that the guidelines focus on; (2) targeted age groups (children or adults); and (3) breadth and depth of coverage, such as for particular inhalant allergens or food allergies only. Based on the information provided by MIMS website (updated in 2011 by Research Article British Journal of Medicine & Medical Research, 2(2): 157-171, 2012 158 UBM Medica, London, United Kingdom) and the MIMS proven by the country's local health authority, controversies exist in recommended minimum age, doses and potential side-effects of many commonly used 2 nd -generation antihistamines and intranasal corticosteroids. Conclusion: This is the first study that demonstrates discrepancies and a lack of public education programmes for AR prevention and management in Asia-Pacific countries/regions.


In this paper we introduce GRAPP&S (Grid APPlication & Services), a multi-scale framework for an unified storage and indexing of both data and services. Indeed, GRAPP&S was designed to support different data formats such as files, stream or database queries, but also to support the access to distant services (web services, cloud services or HPC computing services, for example). GRAPP&S coordinates an hierarchical routing architecture that allows data indexing and access, thanks to a multi-scale network of local-area communities. Transparent access is provided by a network of specialized proxies, which handle most aspects related to data loCopyright is held by the author/owner(s) UbiMob 2013, 5–6 juin 2013, Nancy, France. cation, request handling, data preprocessing/summary and also data consistence. Furthermore, GRAPP&S infrastructure can be easily enhanced to ensure security and confidentiality inside a GRAPP&S community and among different communities.


Hydrolytic model of two chitosanases of chitosan,ChiB and ChiA,separated and purified from a culture filtrate of Aspergillus CJ22-326,was investigated.The experimental results on the viscosity changes of reaction solution and analysis of enzymatic hydrolysis products by TLC and HPLC showed that ChiB was an endo-type cleavage enzyme.ChiB decreased the viscosity of reaction solution significantly,hydrolyzed β-(1,4) glucosidic bond of chitosan at random.Using chitooligosaccharides as substrates,ChiB acted on GlcN-GlcN and did not act on GlcNAc-GlcNAc glucosidic bond.Chitooligosaccharides with the degree of polymerization below 5 could not be hydrolyzed by ChiB.Hydrolysis products of chitopentose were chitobiose and chitotriose.The latter was the main product of chitohexaose hydrolysis.ChiA was an exo-type amino-glucosidase which mainly cleaved glucosamine residue from non-reducing end of chitosan or chitooligosaccharides.ChiA acted only on GlcN-GlcN and GlcN-GlcNAc glucosidic bonds.


In a recently published paper, Carrascosa et al. (1) bring to our attention the relevance of the proinflammatory activities of adipokynes in psoriasis and the catalyzing role of obesity in precipitating the metabolic syndrome and the associated cardiovascular disease in obese or overweight psoriatic patients. A recent study (2) analyzed the role of antibiotic in early life on the intestinal microbiota composition in a rat model. Early life is a critical period both for the intestinal microbiota, as mice are particularly vulnerable to exposure at low-dose antibiotic in this period (3). In this study, cecal microbiota from 18-week-old controls and penicillin-treated mice were transferred to a 3-week-old germ-free mice to investigate the effects on body composition and metabolism (2). Mice that received penicillin-altered microbiota become more fat than those that received microbiota from controls independently to others factors. Translated to humans, we must be aware that some procedures, such as cesarean section (4) and early treatment with antibiotics (5), increase the risk of obesity later in men.


A continuous method of monitoring the depth of corrosion of a metal material, a metal which is measured by a measuring apparatus, the probe and clamp, wire, sheet resistance measuring instrument, computer. By measuring the metal side resistance, corrosion depth to obtain different metal etching time. Advantage of the present invention are: to overcome the disadvantages of the conventional burying test studies like metal corrosion and electrochemical etching method and reinforced concrete, fill soil corrosion of metal, reinforced concrete corrosion direct, continuous monitoring method blank, has broad application prospects, significant economic and social value.


2.3. Manipulations required to convert the risk factor maps into raster maps for inclusion in the multicriteria decision model to estimate the risk of spread of HPAIV Sensitivity analysis of the factors and weights used to estimate and map the risk of spread of HPAIV H5N1 in Indonesia. The average change in risk estimates was calculated from 1000 randomly-selected locations.. Sensitivity analysis of the distance scale used to produce the distance and density risk factor maps for Indonesia. The average change in risk estimates was calculated at 1000 randomly-selected locations..


A further study of the field-reversed ion layer equilibria is presented (Part I was published in Nucl. Fusion 21 (1981) 1633). The formalism for introducing steady-state perturbations into the equilibria presented in Part I is applied to the problem of a perturbing rigid rotor ion current and analytic solutions are obtained. The problem of an equilibrium altered by a perturbing group of ions of differing canonical angular momentum is solved iteratively. The results of these studies are that the primary ion currents readjust so as to largely nullify the effect of the perturbations, tending therefore to preserve the unperturbed field reversal values. The effects of finite temperature electrons on the equilibrium are considered, using a 'Boltzmann model' for the electrons. As for the two perturbed cases, the field reversal ratio tends to be preserved at the value occurring in the unperturbed case. In support of the results, a variational principle is presented which shows the equilibria to be minima of magnetic and rotational kinetic energies.


To the best of the author's knowledge, this is first empirical paper to examine the tendency of U.S. corporate firms to engage in window dressing behavior in cash holdings. Using quarterly financial data, S&P constituents' data, and S&P issuer credit rating data from Compustat, stock price data from Center for Research for Security Prices (CRSP), and governance index data, we find evidence of upward window dressing in cash holdings during the fourth fiscal quarter (financial year-end) even after controlling for corporate cash holdings determinants. This window dressing behavior is widespread across subsamples based on size, competition, risk, governance, and level of information asymmetry. Our findings further suggest that the upward window dressing in corporate cash holdings towards fiscal year-end is sensitive to firm size and to some extent the level of information asymmetry.


The research, concerning influence of transcorneal dialysis of drugs in penetrating eye wounds with injury and further lens removal in the case of intraocular infection (16 patients). It was revealed high therapeutic effectiveness of the method in suppression of intraocular infection.


ABSTRACT A total of 117 honeysuckle (Lonicera japonica Thunb.) samples from four major regions of production in China, including Fengqiu in Henan, Pingyi in Shandong, Julu in Hebei, and Xiushan in Chongqing, were analyzed to determine their geographical origin. δ13C, δ15N, and δ18O values were determined by isotope ratio mass spectrometry (IRMS), and the contents of 18 elements (Fe, Mn, Cu, Zn, K, Ca, Mg, Pb, Cd, Cr, As, Hg, Se, Sr, Ni, Co, B, and Mo) were measured by inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Multivariate statistical analysis by analysis of variance (ANOVA), principal component analysis (PCA), and linear discriminant analysis (LDA) were performed. The results showed that there were very significant differences in the stable isotope ratios and elemental concentrations in honeysuckle based on geographical origin, with plants from each region having a unique fingerprint. Discriminant functions were established to distinguish the origin of honeysuckle using suitable indicators including Cd, Cr, As, Hg, Se, Co, Ni, Sr, Fe, δ13C, δ15N, and δ18O. Cross-validated cases of 95.7% were correctly classified.


The article considers modern approaches to forming the language personality of a student of pedagogical college. The authors propose to use high school technologies of teaching the Russian language with the elements of business communication and practical rhetoric


The size and position of mitotic spindles is determined by the lengths of their constituent microtubules. Regulation of microtubule length requires feedback to set the balance between growth and shrinkage. Whereas negative feedback mechanisms for microtubule length control, based on depolymerizing kinesins and severing proteins, have been studied extensively, positive feedback mechanisms are not known. Here, we report that the budding yeast kinesin Kip2 is a microtubule polymerase and catastrophe inhibitor in vitro that uses its processive motor activity as part of a feedback loop to further promote microtubule growth. Positive feedback arises because longer microtubules bind more motors, which walk to the ends where they reinforce growth and inhibit catastrophe. We propose that positive feedback, common in biochemical pathways to switch between signaling states, can also be used in a mechanical signaling pathway to switch between structural states, in this case between short and long polymers. DOI: http://dx.doi.org/10.7554/eLife.10542.001


Bacillus anthracis protective antigen (PA) has been produced from a recombinant B. subtilis and its efficacy, when combined with the Ribi adjuvant (MPL‐TDW‐CWS) or alhydrogel, has been compared with that of the licensed UK human vaccine, in guinea pigs challenged with aerosolized Ames strain spores. Recombinant PA combined with the Ribi adjuvant performed as well as PA from B. anthracis cultures in previous reports ( Ivins & Welkos 1986 ; Ivins et al. 1990 ; Turnbull et al. 1991 ; Jones et al. 1996 ; McBride et al. 1998 ) giving protection in 100% of animals exposed to the highest challenge dose of the Ames strain of B. anthracis that can be administered practically (retained lung doses of approximately 106 spores).


A 25-year-old man presented to the trauma center with gunshot wounds to the left shoulder and left lower quadrant.

The patient was combative and diaphoretic with a systolic blood pressure of 100 mm Hg and a heart rate of 132 beats per minute. He had a single gunshot wound to the soft tissue of the superior aspect of the left shoulder, with normal pulses at the left wrist and a normal neurological examination in the left upper extremity. His abdominal examination was significant for a gunshot entrance wound in the left lower quadrant and diffuse peritonitis. The right femoral pulse was not palpable.

After blood was drawn for type and cross-match, a surgeon-performed ultrasound was 'negative' for a hemopericardium and a left hemopneumothorax. A massive transfusion protocol was initiated, and a cephalosporin antibiotic was administered. On the first set of arterial blood gases, the pH was 7.11 with a base deficit of −17.5. After transport to the operating room, the patient was intubated, a midline exploratory laparotomy was performed and 2 L of hemoperitoneum were evacuated. There were multiple enterotomies in the small bowel, transection of the right external and internal iliac arteries and near transection of the right spermatic cord. Intestinal clamps were rapidly placed at the sites of enterotomies. Progressive hypotension mandated manual compression of the supraceliac abdominal aorta. A vascular clamp was then applied to the right common iliac artery, and the distal end of the right internal iliac artery was clamped and ligated. As the distal end of the right external iliac artery had retracted under the inguinal ligament, the midline abdominal incision was extended obliquely across the inguinal ligament into the right groin. A vascular clamp was then applied to the distal end of the right external iliac artery. The right spermatic cord was ligated. …


The development of a new low-cost, low-power, electrical resistivity tomography system (PRIME - Proactive Infrastructure Monitoring and Evaluation) is described. PRIME is designed to provide continuous near-real-time information on the internal condition of the earthworks, helping to predict failures and enable timely intervention. Conventional asset monitoring involves examining the surface (either by people on the ground or from aerial photos) and using point sensors, such as moisture content and tilt meters, which only give information in the immediate vicinity of the sensor. But PRIME uses imaging for the volumetric tracking of moisture content changes and the detection of ground movement, thereby identifying problems at a much earlier stage. An example of the deployment of PRIME to monitor a leaking canal embankment is also provided.


The method of signal correlation of microwave responses as applied to the measurement of Earth-surface ice temperatures from orbit is explained and summarized. Ice temperatures are estimated by a correlation function that is derived from the processes of a forward stepwise correlator. Subsets of the post-detected outputs of microwave receiving channels are combined in a multivariate cross-correlation function which operates as a spatial filter and serves to improve the spatial resolution of the thermal gradients in ice structures. The correlator is designed to selectively identify the correlative components among the microwave responses and to strongly suppress or cancel the non-correlative components appearing in the post-detected outputs.


This presentation argues that we seldom speak of our findings in qualitative research as serendipitous, although we have splendid possibilities to make surprising findings. In order to enhance the chances and sharpen our analyses we have to read broadly but also pay attention to details in our data. We should avoid societal or scholarly conventionality, even be disobedient to recommendations, if this blinds us to new meanings of our findings. The value of serendipitous findings lies in the fact that they diverge from conventionally held knowledge. Thus, we have to retain our curiosity, with the "strange intoxication" or passion that Ma XWeber wrote about in Science as Vocation.


To investigate the relationship between fabric anisotropy and macroscopic stresses of granular soils, threedimensional discrete element analysis was performed. Eight triaxial stress probing tests were simulated, and the variation of the degree of fabric anisotropy was estimated in terms of the cross-anisotropic fabric tensor. Regardless of the direction of stress paths, there was a unique relationship between the degree of fabric anisotropy and the stress ratio in lower stress ratios ranging from -0.1 to 0.6.


A new di-block acrylate copolymer with a Copper-Phthalocyanine (CuPc) core has been synthesized via a multi-step reaction scheme involving the atom-transfer radical polymerization. This material displayed amphiphilic character and consists of a CuPc core with eight copolymer arms. This new amphiphilic material and related intermediates have been characterized by UV-Vis, FT-IR, 1H-NMR and elemental analysis. A preliminary study involving self-assembly properties of this material by optical, atomic force and scanning electron microscopies is presented.


The Co3sfe6s magnetic thin films with Cu underlayer were prepared and characterized using RF magnetron sputtering. Nano under layer effects on the magnetic properties and crystalline structure of the film were investigated for the GHz frequency use. It was found that the underlayer was very effective in inducing elongation of lattice parameter, preferred crystalline orientation, and decrease of crystallite size. These effects were attributable to a reduction of surface energy in the underlayer and led to improve remarkably the magnetic properties for the GHz frequency use above 1 0 GHz.


The study reported in this paper investigated the effect of a simultaneous secondary task on subject's ability to judge time-to-collision (TTC). Using the Leeds Driving simulator, subjects watched as they appeared to approach, at one of two constant speeds, a texture-less distant object along a flat straight road in a randomly undulating scene. At predetermined points the subject was instructed to look at an in-car display, at which point the approach to the target object was no longer presented. The subject's primary task was to decide when the vehicle in which he or she was travelling would collide with the target. Three secondary task conditions, using the in-car display were studied: (1) where the subject had to perform a difficult signal detection task; (2) an easy signal detection task; and (3) no secondary task during the TTC estimation phase. The results showed the expected difference in ability to perform the easy and difficult secondary task, but an increased collision rate (ie overestimation of TTC) and reduced TTC error in these secondary task conditions. The fact that these tendencies in TTC estimations also reflected the difficulty level of the secondary task suggests that what some have regarded as 'direct' perception is disrupted by cognitive load. The results obtained are interpreted as showing that the TTC task depend in part on prospective duration estimation, which is itself sensitive to ongoing cognitive load. The use of the TTC estimation task as a means of assessing the impact of distraction from in-car devices is discussed. (A) For the covering abstract see ITRD E106152.


With the rise of information technology,the application of network has penetrated into all aspects of social life.As a new type of teaching media,online teaching integrated into the professional curriculum,which constituted the new teaching model together with teachers,students,teaching materials and multimedia,and realized optimization of the process of teaching.Referring to the diversification strategy theory in management,combined with the changes of teaching philosophy in the new era,the network teaching platform shows a strong advantage and strength in diversified teaching activities,playing a full role in shools.


As device interconnects continue to scale, copper metallization and low dielectric constant materials will begin as soon as the 180 nm technology. The damascene approach with either CVD or PVD conformal coverage of good diffusion barrier layers, enhanced filling of Cu by CVD or electroplating as well as chemical-mechanical polishing of low-k material and Cu may be required to achieve high-level integration.


In this lecture note we consider another class of performance modelling languages— stochastic extensions of process algebras, particularly the stochastic process algebra, PEPA. Like queueing networks and stochastic Petri nets, and their variants, these formal languages can be regarded as high-level model specification languages for low-level stochastic models. As we will see, the development of SPA has been very similar to that of SPN: in both cases an untimed formalism, used for studying the correct functional behaviour of systems, is extended by associating exponential delays with actions and reachability analysis is used to construct a corresponding Markov process. Process algebras emerged as a modelling technique for the functional analysis of concurrent systems approximately thirty years ago. Over the last twenty years there have been several attempts to take advantage of the attractive features of this modelling paradigm within the field of performance evaluation. Stochastic process algebras (SPA) were first proposed as a tool for performance and dependability modelling in 1990. Compared with existing performance modelling formalisms SPA offered something new—formally defined compositionality. Queueing networks, have an inherent compositionality but this is implicit and informal. As we have seen stochastic extensions of Petri nets have a semantic model but, in general, no clear compositional structure. In the process algebra the compositionality is explicit—provided by the combi-nators of the language—and formal—supported by the semantics and equivalence relations of the language. It was immediately clear that having this explicit structure within models offers benefits for model construction: • when a system consists of interacting components, the components, can each be modelled separately, and then composed to form the larger system; • models have a clear structure and are easy to understand; • models can be constructed systematically, by either elaboration or refinement; • the possibility of maintaining a library of model components, supporting model reusability, is introduced. Furthermore researchers have shown that in some cases the compositional structure in the model construction can be exploited during model analysis, meaning that a number of smaller Markov processes can be solved instead of a single large one. Process algebras are abstract languages used for the specification and design of concurrent systems. The most widely used process algebras are Milner's Calculus of Communicating Systems (CCS) and Hoare's Communicating Sequential Processes (CSP) and the SPAs


Background:  Early laparoscopic cholecystectomy has been shown to be the treatment of choice for acute presentations of gallstone disease. However, currently this practice is not common in many centres. The aim of the study was to evaluate surgical management of patients presenting with acute symptomatic gallstone disease to Middlemore Hospital in 2005.


This discussion paper aims to highlight the existing scenario of Technical and Vocational Education and Training (TVET) for the economic growth in Pakistan. It specifically analysis the status of vocational training, related policies and practices with reference to the 18th Amendment, which abolishes the concurrent list and grants more provincial autonomy in the matters of education. Article 25A of the Constitution of the Islamic Republic of Pakistan (iv) states that the provinces should set priorities for access and quality education based on the provincial needs and develop action plans for its actualization. A developing country like Pakistan needs to devise a systematic, well thought and sophisticated policy for TVET; therefore, this paper proposes a policy following the simple framework of input, process and output. The inputs are predominantly focused on highlighting and matching demand and supply of the TVET. The process thoroughly discusses both the formal and informal education arrangements. Finally, the outputs are deliberated in the form of economic effects such as the manpower structures, technological development, manpower quality and economic behavior leading to the ultimate goal of economic growth and development of the country.


Reverse total shoulder replacement is a viable surgical option for Cuff Tear Arthropathy. Short term results have been promising. Longer term follow-up has demonstrated a high rate of scapular notching. This is attributed to mechanical impingement between the humeral cup and scapular neck when the arm is fully adducted. The long term sequelae of scapular notching are unclear but there is concern that it may compromise fixation of the glenoid component and affect functional outcomes. Design modifications to address this problem include the newly available eccentric glenospheres and larger diameter glenospheres. These glenospheres are designed to offer greater ranges of motion and theoretically may reduce the risk of impingement and notching. The purpose of this biomechanical study is to demonstrate the difference in range of motions with each design of glenosphere. To our knowledge there is no published literature evaluating this design differences. The SMR (Lima Orthotec) reverse total shoulder prothesis was implanted into a synthetic bone model (Sawbones, Pacific Laboratories, Vashon, Washington). Four different types of glenospheres (Standard 36 mm, Eccentric 36 mm, Standard 44 mm, Eccentric 44 mm) were then implanted into the same model which was fixed on a measurement table. The precision coordinate measurement device (FARO-Arm, SO6/Rev22, FARO Technologies Inc., Lake Mary, Florida) was used to establish the centres of rotation and ranges of motion. To date, the collection of data has just been completed, but the data are yet to be analysed. In conclusion, this is a biomechanical study evaluating the ranges of motion and risk of notching, comparing different designs of glenospheres in Reverse Total Shoulder Joint Replacement.


This article introduces the findings of social psychology, especially group psychology, into the study of investment arbitration. It argues that arbitrators as members of small groups (i.e. tribunals or divisions in an Investment Court) might be subjected to a number of influences inherent to such collective settings—factors already proven to be at play in domestic courts. In turn, identifying those factors provides an opportunity to reduce their impact on the decision-making of legal adjudicators through the implementation of adequate remedies. Adopting one of the most popular models of group decision-making—groupthink— this article discusses the manifestations and implications of this theory for Investor-State Dispute Settlement both in its ad hoc and institutionalized forms. Specifically, it claims that the Investment Court defended by the EU and generally posited in some agreements might not be that different from the current system from a socio-psychological perspective, and hence could be further improved.


At first,this paper studied technology and method of alert correlation for analyzing their advantages and disadvantages.Then,presented alert correlation model based on multi-sources data fusion.After that,discussed evaluation dataset for analyzing their used scope and existent problems.At last,described future research and development.


The spermatozoon of the polychaete Tomopteris helgolandica is of an aberrant type with two flagella, each measuring about 40μm. The nucleus is roughly conical and weakly bent. At the anterior end it is rounded and covered only by the nuclear and plasma membranes. Membraneous, electron-dense structures are applied laterally to the nucleus. These structures may have a helical arrangement. The middle piece contains about ten mitochondria, two centrioles, and two centriolar satellite complexes. The centriolar regions are connected with the posterior part of the nucleus. The axonemes of the two tail flagella lack the usual central complex with central tubules, radial spokes, or related structures. No arms seem to be present on the A tubules of the doublets. In the middle piece the tail flagella are surrounded by invaginations of the plasma membrane forming flagellar canals. The sperm has a bilateral symmetry whereas the primitive sperm has a radial symmetry. The occurrence of two tail flagella in this spermatozoon has no phylogenetical connection with biflagellate spermatozoa in other animal groups. A series of mutations has resulted in the development of two flagella emerging from the two centrioles, the lack of a central complex in the axoneme, and the lack of a typical acrosome. In the Polychaeta, sperm structure is generally more related to function that to phylogenetics. During swimming the spermatozoon of Tomopteris rotates around its longitudinal axis.


Effective natural-convection-cooled heat sinks are vital to the future of electronics cooling due to their low energy demand in the absence of an external pumping agency in comparison to other cooling methods. The present numerical study was carried out with ANSYS Fluent and aimed at identifying a more-effective fin design for enhancing heat transfer in natural convection applications for a fixed base-plate size of 100 mm × 100 mm under an applied heat flux of 4000 W/m2. The Rayleigh number used in the present study lied within the range of 2.6 × 106 to 4.5 × 106. Initially, a baseline case with rectangular fins was considered in the present study, and it was optimized with respect to fin spacing. This optimized baseline case was then validated against the semi-empirical correlation from the scientific literature. Upon good agreement, the validated model was used for comparative analysis of different heat sink configurations with rectangular, trapezoidal, curved, and angled fins by constraining the surface area of the heat transfer. The optimized fin spacing obtained for the baseline case was also used for the other heat sink configurations, and then, the fin designs were further optimized for better performance. However, for the angled fin case, the optimized configuration found in the scientific literature was adopted in the present study. The proposed novel curved fin design with a shroud showed a 4.1% decrease in the system's thermal resistance with an increase in the heat transfer coefficient of 4.4% when compared to the optimized baseline fin case. The obtained results were further non-dimensionalized with the proposed scaling in terms of the baseline case for the two novel heat sink cases (trapezoidal, curved).


A novel SAR image segmentation algorithm LMFCV-SIS based on local median fitting(LMF) C-V model was proposed according to the characteristics of SAR images.The main idea of the algorithm is to use the LMF of the pixel and its neighbors to form an energy and the final evolution of the curve was given by the minimization of the energy.The performance of the approach was verified by plenty of real airborne SAR images and the experimental results from the real data show its efficiency and accuracy.


The furniture industry is growing to a great extent in Bangladesh. Many market researchers believe that the industry has enormous potentiality. However, the expansion of this industry may face complexities within a few years. Due to the wrong selection of facilities, many organizations failed to earn profit as expected. It also needs a large investment. Selecting a suitable place for a new facility is going to be the biggest question of upcoming years. This study aimed to analyze Bangladesh's furniture industry, address the facility location problem, and provide a constructive solution to the decision-makers. In this study, seven criteria were considered: availability of raw materials, transportations, skilled labor, proximity to customers, energy availability, economic zone facility, and environmental impact, and five ideal locations or alternatives: Khulna, Chattogram, Bogura, Gazipur, and Manikganj. Thirty-four experts took part in the survey to analyze the significant criteria for selecting a furniture industry's facility location and alternatives or potential locations for the facility. The Analytical Hierarchy Process (AHP) and Fuzzy AHP methods (FAHP), two MCDM techniques, were used to analyze the data set. A sensitivity analysis was done to determine the model's robustness for any critical changes in the real world. The result showed that 'energy availability is the most significant criterion to select a facility location for the furniture industry, where it got 35.1% criteria weight in AHP and 33.9% in FAHP. 'Chattogram' was selected as the most suitable place containing 33.74% normalized weight in AHP and 33.81% normalized weight in FAHP.


Abstract Monitoring computer users' behaviour to enhance the usability of software has become increasingly popular among the developers of computer products. One objective of this paper is to compare the use of a software monitoring technique with other field observation methods. It is argued that when contrasted against traditional observation techniques, the software monitor provides a more accurate and unobtrusive approach to collecting behavioural data on larger samples of individuals for longer periods of time than either participant observation or Thinking Aloud methodologies. A second objective is to demonstrate the application of software monitors on installed multi-user systems. Technical aspects of software monitor design are discussed, with emphasis on specific practical problems in monitor design and utilization when making the transition from the laboratory to an office environment. Data from two studies are presented. The first illustrates how a software monitor can be used to determine the ...


This paper is about migration from a small Cycladic island (1) to Athens, the capital city of Greece, and chiefly concerns those male migrants for whom migration entails a change from agricultural labour to work in the building trade. The first part of the paper briefly sets the depopulating island of Nisos in the context of Greek rural depopulation, migration within and from Greece, and the growth of Athens. Migration from Nisos from 1840 to 1940 fitted into traditional expectations about an island-man's wage-earning activities at a certain stage in his life and is therefore interpreted here as supporting established island institutions. Migration since World War II and the Greek civil war (1945–49) is interpreted as transforming island life and even threatening the continued existence of a viable community. The second part of the paper gives an account of the involvement of Nisiot migrants in the building trade as workmen, subcontractors and property-owners, and discusses the tensions which have arisen between members of old-established migrant families and more recent migrants enriched by the building boom.


Little, if any, information regarding the effects of seawater immersion on the impact resistance of composite materials has been published to date. In the present study, instrumented impact tests were used to characterize such effects for two glass fiber reinforced epoxy composites. One material consisted of continuous nonwoven E-glass fibers in a conventional epoxy resin and the other consisted of woven E-glass fibers in a rubber toughened epoxy resin formulated specifically for marine applications. In the conventional epoxy system, the energy for incipient damage increased significantly follow ing seawater immersion due to plasticization of the matrix by the absorbed moisture. Both glass/epoxy systems experienced substantial reductions in peak load and energy absorbed at peak load as a result of moisture-induced degradation of the fibers and fiber/matrix interface. Energy after peak load decreased in the conventional epoxy system follow ing immersion. Total energy absorbed was reduced significantly for both glass/epoxy systems following seawater immersion. These results indicate that moisture-induced degradation can significantly reduce the impact resistance of glass fiber reinforced epoxy composites.


Danville, Pa. - Hand dermatitis can be difficult to diagnose and treat, according to Christen M. Mowad, M.D., assistant professor, department of dermatology, Geisinger Medical Center, Pennsylvania State College of Medicine.


The aim of this study is to construct an Islamic learning media using Macromedia Flash on curved side geometry subject. The type of this research is a development research which refers to ADDIE (Analysis, Design, Development, Implementation, and Evaluation) model. The result of this research indicates that based on the assessment of the media experts, the learning media have been valid and Based on the assessment of contain experts the learning media have been valid. The results of questionnaire responses of teachers, questionnaire responses of students, and interviews with students indicate that the learning media have been applicated by teachers and learners.


i) and immunoglobulin G Fc region binding polypeptide having an amino acid sequence selected from the amino acid sequence having at least 95% identity thereto is provided. Methods of producing the polypeptides, compositions comprising the aforementioned polypeptide, the polynucleotide encoding the polypeptide, multimers of the polypeptides, and methods of using the polypeptides are also provided. .The


This paper is about Psychooncology and his vision of cancer patients. The authors analyze the importance of coping and resilience like modulators in cancer patient health.  The contributions of many investigations in this field are important to understand the resilience and coping value in the oncology patient evolution. The author offers conclusions about this topic and invites to consider this field like a priority in futures research.


Self-regulation is an active and constructive process whereby students set goals for their learning and then attempt to monitor, regulate, and control their cognition, motivation and behavior. The aim of the present study is to measure self-regulation among adolescents studying in five schools of district Shopian. For this purpose, self-regulation questionnaire (SRQ) standardized by Ryan and Connel (1998) was administered to the sample of 100 adolescents. Of these 50 were male and 50 were female students. The main findings are: Significant difference were found between the two groups, on sub dimensions, namely, Friendship self-regulation, Religious self-regulation, Pro-social self-regulation, Academic self-regulation and composite scores of self-regulation. Introduction Adolescence is the most important period of human life. Poets have described it as the spring of life of human beings and an important era in total life-span. The word comes from a Greek word 'adolescere' which means 'to grow to maturity'. Self-regulation is a comprehensive construct that involves complex interactions among cognitive, metacognitive and motivational strategies (Boekaerts, Pintrich, & Zeidner, 2000; Butler, 2011). Self-regulation is a cyclical process of cognitive engagement in which purposive behaviour is planned, adapted and evaluated (Butler & Winne, 1995; Zimmerman, 2000, 2001). Typically the whole process revolves the three or four phases it is depending upon the use different forms of cognitive engagement, which are usually ordered in time but which are not hierarchical, thereby allowing the possibility of phases operating simultaneously and dynamically (Pintrich, 2004). Self-regulation refers to students self-generated thoughts, feelings, and actions which are systematically oriented toward the attainment of goals (Zimmerman, 1994), and the use of internalized self-regulatory strategies help individuals to achieve in school (McCoach, 2002). Self-regulated learners actively avoid behaviors and cognitions detrimental to academic success; they know the strategies necessary for learning to occur and understand when and how to utilize strategies that increase perseverance and performance (Byrnes, Miller, & Reynolds, 1999). In fact, self-regulated learners view learning as a controllable process: they constantly plan, organize, monitor, and evaluate their learning during this process (Ley & Young, 1998). Self-regulated learning is a multidimensional construct that emphasizes the active role of the learner (Abar & Loken, 2010). The majority of educational psychologists agree that effective learning requires students' to self regulate their motivation cognition and behaviour (Zimmerman, 1989). Canzana (2012) found that self-regulation has positive relationship with academic adjustment. It means that self-regulation is directly or indirectly related with academic performance and social adjustment. Students are self-regulated to the degree that they are meta-cognitively, motivationally and behaviorally active participants in their learning process (Mega et al (2014). Zimmerman & Kitsantas (2014) found self-regulation was more predictive of student's grade point average and performance it implies that when an individual have self-regulation his/her academic performance will be good. Kurd et al (2014) also found highest relationship of self-regulation with academic performance. It was also found that academic performance was positive and significant effect on self-regulation. It implies that when student can use self-regulation techniques, they should have better academic performance. Gupta (2012) found that spiritual intelligence and emotional intelligence have positive and significant relationship with selfregulation and self-efficacy, significant difference was found among boys and girls in terms of self-efficacy, emotional intelligence and self-regulation. Objectives The objectives of the present study are: 1. To examine the differences of means in all the sub dimensions of self-regulation between male and female adolescents. 2. To examine the difference between male and female adolescents on composite scores of self-regulation. Hypotheses 1. There exists no significant differences of means in all the sub dimensions of Self-regulation between male and female adolescents. 2. There exists no significant differences of means in Self-regulation between male and female adolescents. Method The present study is descriptive in nature. 100 female and male adolescents served as participants in this study. The age range of participants was from 15-17, years. Participants were drawn from five schools of district Shopian. Measure Self-regulation questionnaire developed by Ryan and Connell (1998) was used to measure self-regulation of adolescents. Four components of self-regulation viz. Academic self-regulation, Pro-social self-regulation, Religion self-regulation and Friendship self-regulation are covered in the test. 89 items constitute the test. Each item in the form of


Background: Asthma medication is amongst the most frequently prescribed drugs in children. In 2016, the European Medicines Agency (EMA) published a new inventory of paediatric therapeutic needs, highlighting the need for more safety information on asthma medication. Aim: To identify safety signals related to asthma medication in children. Method: Spontaneous reports received in the EudraVigilance database between 2011-2015 were investigated. New safety signals were identified through the calculation of the proportional reporting ratio (PRR) as a measure of disproportionality (PRR>1 was considered a signal). Stratification by age and gender was performed. To control for confounding by indication, we restricted to all asthma medication as reference category. Results: 15,284 drug-event pairs from 4,086 individual pediatric safety reports concerning asthma drugs were analysed. New safety signals were found: pneumonia with various inhaled corticosteroids (ICS) (e.g. fluticason: PRR 5.9, 95% CI [4.0-8.8]), adrenal suppression with various ICS (e.g. triamcinolon: PRR 612.4, 95% CI [356.8-1050.8]) and several psychiatric disorders associated with montelukast (e.g. obsessive thoughts: PRR 32.7, 95% CI [13.5-78.7]). Stratifying by gender did not affect signals while restricting to asthma medication influenced the strength of the signal and eliminated confounding by indication. Conclusion: It is important to investigate safety signals in children using spontaneous databases. We confirmed already known signals and identified new safety signals like risk of pneumonia in children using ICS. This association has already been studied in adults (mainly COPD patients) and needs to be further investigated in children.


The drug formulation in the context Maku腔 (SCS) on the eye of a human subject for the treatment of posterior segment disorders or choroidal disease in non-surgical provides methods and devices for targeting administration. In one embodiment, the methods comprise the step of injecting a drug formulation choroidal space on the eye via the steps and inserted microneedle inserting a hollow microneedle insertion site within the eye, wherein in the injected drug formulation flows into the upper choroid space flows out of the insertion site during the injection. In one embodiment, the flowable drug formulation comprises a drug nanoparticles or fine drug particles.


While Ethiopian Christianity has been deduced as a 300s CE phenomenon, a late comer in the narrative of Christianity and the one detached from biblical and apostolic tradition, there appears to be ground for alternative theorem. A case for 1st century CE Christianity in Ethiopia is derived from the biblical account of the baptism of a diplomat titled an Ethiopian eunuch in Acts 8:26–38. The reference to Ethiopia, possibly Aksum, a notable empire South of Israel adjacent to the Arabian Peninsula, adds ground for the investigation regarding the possible existence of Christianity before Ezana (cf. Kaplan 1982). This theory would be deriving from the parallel spread of apostolic Christianity in related regions such as India. The royal conversion of Ezana through the Syriac influence of Frumentius is a 4th century CE phenomenon. Although this tallies with the established epigraphic and literary documents pertaining to Ethiopia, this does not corroborate a relatable synthesis with the New Testament Lukan Acts. The visibility of Ethiopia and Southern Arabia in Hebrew heritage, as recorded during the golden age of Solomon, logically implies that in the effort to spread Judaism's protégé Christians inadvertently would assert their position firstly amongst those relatable to Israel and Judaism.


The literatures on differential commodity taxes and on quantity controls to supplement income taxation have developed separately. This paper combines these two strands in the standard framework of optimal non-linear income taxation. We use a model with two types of households where the government has access to both subsidy policy and public provision of a good substitutable for leisure, and households can supplement the publicity provided good from the market. We present conditions under which policy should involve one or both of these two instruments alongside income taxation. The model is extended to many ability types.


The nature of ego functions of the professionals in Kolkata, who have chosen performing (music, dance, & acting) and visual (painting & photography) art as their career, in comparison to a control group of non-artist professionals has been investigated in the present manuscript with the purpose of understanding the effect of such statistical functions on creative personalities. The sample constituted of 150 artist professionals and 150 non-artist professionals from Kolkata within age range of 20 to 40 years, including respondents of both the genders. The control group was matched with the study group in terms of relevant demographic variables. The tool used to obtain the findings was Ego Function Assessment (EFA) Scale, as modified by Bellak (1989). The EFA scale assessed twelve separate ego functions viz., Reality Testing, Judgment, Sense of Reality, Drive Control, Object Relation, Thought Process, Adaptive Regression, Defense Functioning, Stimulus Barrier Autonomous Functioning, Synthetic-Integrative Functioning and Mastery Competence. Descriptive and multivariate tests were used for statistical analysts of data. The data analysts revealed significant differences between the two groups, and between the genders in terms of ego functions. The creative's had poorer ego functions on many respects, but had higher adaptive regression. However, their differing perspective of emotions (as indicated by higher adaptive regression) may account for their specialty. Suggestions for mental health management of creative persons require awareness on the part of the mental health workers in this regard.


This paper presents a feasibility analysis of microwave photonic links for signal distribution in active aperture radar. Phased array radar antenna uses large number of transmit/receive modules spread over the entire physical area of antenna. The received echo signal is processed with the help of various microwave and data signals. This requires distribution of large number of coaxial cables across antenna panel to perform beam forming and other signal processing functions for target detection. An optical distribution network is proposed for transmission of multiplexed microwave signals on single optical fiber on the basis of link power budget calculations. The results have been experimentally tested for S band frequency signals from 50MHz to 4GHz. Analysis is also carried out to observe the effect of extreme temperature on performance of optical components.


This paper, after optimization of the vertical slab in screw tire-shaping vulcanizing machine taking the method of FEM, shows that the stiffener-inside slab is better than the stiffener-outside, the slab with the structure of stiffeners is better than the bare-board one. Meanwhile, it cuts about 23.69% cost of the steel to take the optimized scheme.


Jerusalem artichoke tubers have diverse applications in the food industry as well as in biotechnology. Their suitability depends mostly on the inulin content. Seasonal fluctuations of fructan exohydrolase activity responsible for inulin degradation was investigated in the tubers of three Jerusalem artichoke cultivars. The changes of fructan exohydrolase activity positively correlated with the changes of the content of total and short fructooligosaccharides. Therefore, to extract inulin with higher degree of polymerization for biotechnological purposes, the tubers of Jerusalem artichoke should be uprooted in autumn before the level of fructan exohydrolase reaches its maximum. If short fructooligosaccharides are desirable, the tubers in late autumn or spring tubers overwintered in soil are suitable.


Background: In the face of investigations on how Amazonia is presented in textbooks (TBs), it is clear that there is a limitation in approaching this topic, as it is loaded with stereotypes disregarding socio-environmental issues. Objectives: To understand how teaching knowledge is mobilised by teachers from a formative activity centred on investigative teaching sequences in the Amazonian context. Design: With this in mind, we started with an action research. Setting and Participants: It took place in a municipal school in Ananindeu/PA, with the participation of all teachers who worked in the initial years of elementary school of this institution, a total of five teachers, aged between 28 and 49 years. They are the only members of the teaching staff serving the eight classes at the school, in the morning and afternoon shifts, all with a background in pedagogy and at least one specialisation. Data collection and analysis: We used semi-structured collective interviews, recorded in audio and video, which were later transcribed and analysed through content analysis, carried out in three stages: 1 - Pre-analysis, 2 - Exploration of the material and 3 – Treatment of results and interpretation, based on the theoretical framework adopted in the investigation Results: We understand the mobilisation of teaching knowledge in the construction of Investigative Teaching Sequences (ITSs) aimed at the Amazon context, as a viable alternative, since textbooks disregard the reality of Amazonia, making it invisible throughout its entirety complexity. Conclusions: In this sense, the proposition of inquiry-based science teaching through ITSs focused on the Amazonian context favours overcoming this regional neglect. Therefore, teachers and students can start with an investigative process that takes into account relevant and significant themes for both.


The invention discloses a variable-capacitance transistor and a manufacturing method therefor, and relates to the technical field of semiconductors. The transistor comprises a semiconductor fin of a first conductive type; a plurality of grid structures which are disposed around a part of the semiconductor fin and are separated from each other, wherein the grid structures at least comprise a pseudo-grid structure at the edge of the semiconductor fin, and a first grid structure separated from the pseudo-grid structure, and each grid structure comprises a grid insulating material layer on a partof the surface of the semiconductor fin, a grid electrode on the grid insulating material layer, and a separation object for the grid electrode; The transistor also comprises a source electrode or a drain electrode which is located on the semiconductor fin and is lifted between the pseudo-grid structure and the first grid structure. The grid electrode of the pseudo-grid structure and the lifted source electrode or drain electrode are electrically connected to the same level. The transistor can enable the shape of the source electrode and the drain electrode to be neat, can remove the parasiticcapacitance as much as possible, and enables the performances of a device to be more stable.


In order to promote electric vehicle research in Darwin, the Northern Territory Centre for Energy Research in association with the Northern Territory Power and Water Authority (NT PAWA) is developing its own short-range electric commuter vehicle. Outlined below is the procedure used to determine the vehicle specification including range, acceleration and top speed as well as a justification of the type of vehicle used. Also outlined is the vehicle propulsion system which includes an innovative DC-DC converter utilising Maxwell ultracapacitors in parallel with Zinc Bromide batteries and a variable gap axial flux permanent magnet brushless DC machine (BDCM).


A medicine "Jiwenning" for treating chicken pest is prepared from 28 Chinese-medicinal materials including croton seed, oriental wormwood, cyrtomium rhizome, fleece flower etc, etc.


Traumatic ocular injuries are common cause of emergency room visits. Injuries of the globe are a significant cause of blindness and visual deficits. The clinical assessment of globe trauma can be challenging. Some diagnoses can be made clinically, but imaging assessment is often required to determine associated lesions. Computed tomography (CT) allows the timely diagnosis of traumatic injuries of the globe, especially the presence of foreign bodies. In addition, knowledge of the imaging findings in other ocular pathologies that can be confused with traumatic pathologies is important to make an adequate differential diagnosis. The aim of this article is to carry out a review of imaging findings of traumatic ocular injuries.


The article is devoted to one of the main philosophical and aesthetical problems contraposition «beauty-utility» and its solution by the philosophers of different countries and ages, particularly by those of them, who spoke about «disinterested» character of «Beauty», which formed the philosophic base of English aestheticism.


The Full Bayesian Signi cance Test (FBST) for precise hypotheses is presented, with some applications relevant to reliability theory. The FBST is an alternative to signi cance tests or, equivalently, to p-values. In the FBST we compute the evidence of the precise hypothesis. This evidence is the probability of the complement of a credible set \tangent" to the sub-manifold (of the parameter space) that de nes the null hypothesis. We use the FBST in an application requiring a quality control of used components, based on remaining life statistics.


In this study novel prodrug of neomycin with 5-amino salicylic acid (5-ASA) were synthesized and evaluated their potential against In vivo/In vitro model of ulcerative colitis. The presence of azo linkage makes it site specific due to specific cleaves in colon. The synthesized prodrugs are characterized by UV, FTIR, 1 H-NMR and MASS spectral analysis. In vitro analysis of synthesized product shown the stability in HCl buffer (pH 1.2) and phosphate buffer (pH 7.4), which substantiate the avoidance of dissolution of prodrugs throughout upper GIT. The results revealed that prodrugs shows reduction in the extent and severity in stomach ulcerations compared to control. © 2015 iGlobal Research and Publishing Foundation. All rights reserved. Indo Global Journal of Pharmaceutical Sciences, 2016; 6(1): 18-23 19 be mediated through GSH-sensitive processes (antioxidant effects) and the reduction of changes in vascular permeability and decreased cellular infiltration in the mucosa (anti-inflammatory effects) [6]. In presented study, we have synthesized the azo prodrug of 5-ASA and neomycin and evaluate for in vitro and in vivo analysis. Salicylic acid prodrug (SAP) further evaluated against ulcerogenic activity and histopathological analysis. MATERIALS & METHODS All other chemicals used in the synthesis were of A.R. grade and those of synthetic grade were purified prior to use. Sulfasalazine was purchased from Ipca laboratories Ltd., Mumbai, salicylic acid were purchased from GlaxoSmithKline Pharmaceuticals Ltd, Mumbai and Neomycin was obtained from Mr. Deepak Kannujiya, Production Incharge, Quixotic Healthcare, Baddi, as a gift sample. Chemistry Synthesis of azo prodrug of Neomycin with salicylic acid (MXP) Neomycin (0.01 mol; 6.14 g) was dissolved in a suitable volume of water containing 2.5-3 equivalents of hydrochloride acid (0.02mol; 1.7 ml of 35% HCl), by the application of heat if necessary and then solution was cooled in ice. The temperature was maintained at 0-5 0 C on a cryostatic bath and an aqueous solution of sodium nitrite (2 mol, 1.4 g in 10 ml) was added portion wise, through syringe making sure that the tip of the syringe was always dipped completely in the solution. The addition of sodium nitrite solution was continued till the solution gave an immediate positive test for excess of nitrous acid with an external indicator i.e. moist potassium iodide-starch paper. The precipitated neomycin, if any, got dissolved during the diazotization to give a clear solution of the highly soluble diazonium salt. To stabilize the diazonium salt and to minimize secondary reactions, proper condition of acidity was maintained throughout, by adding excess of acid (0.5-1 equivalents). The reaction mixture was kept in cryostatic bath at 0-5 0 C during the course of reaction (which is exothermic in nature), in order to avoid the hydrolysis of diazonium salt to corresponding phenol. Coupling of diazonium salt of Neomycin with salicylic acid Salicylic acid (0.01 mol; 1.38 g) was completely dissolved in sodium hydroxide solution (2 mol; 0.08g/ml). The solution was cooled below 5 0 C. Then slowly diazotised salt of neomycin was added with continuous stirring, through syringe. Alkaline condition was constantly maintained. After completing the reaction, water was evaporated and crude product was recovered. It was recrystallized by dissolving in methanol and cooling at 0 0 C. Purified product was dried under vacuum. M.pt215oC, Rf0.6 (chloroform:methanol, 2:2), percentage yield79%, Aq. Solubility0.63g/ml, log P0.76, max in HCl buffer (pH 1.2): 302 nm and in phosphate buffer (pH 7.4): 308 nm. Scheme: Synthesis of azo conjugates of salicylic acid with Neomycin 1. Synthesis of diazonium salt of Neomycin


Abnormalities in mineral metabolism may play a role in the pathogenesis of CVD. Everett discusses Parker and colleagues' findings in this issue on the association between 3 markers of mineral metab...


A series of ordered mesoporous organic-inorganic hybrid material was designed by using the amine-functionalized SBA-15 (PdX2@SBA-15/NY, Y=1, 2) as solid support for palladium complexes. Among them, the Pd(OAc)2/ethylenediamine complex encapsulated into SBA-15 (Pd(OAc)2@SBA-15/PrEn or Pd(OAc)2@SBA-15/PrNHEtNH2) exhibits higher activity and selectivity toward Suzuki cross-coupling reaction under aerobic conditions and water solvent mixture. The SBA-15/PrEn supported palladium pre-catalyst could be separated easily from reaction products and used repetitively several times, showing its superiority over homogeneous catalysts for industrial and chemical applications. Copyright (c) 2013 John Wiley & Sons, Ltd.


Control Structure Interaction (CSI) is a relatively new technology developed over the last 10 to 15 years for application to large flexible space vehicles. The central issue is recognition that high performance control systems necessary for good spacecraft performance may adversely interact with the dynamics of the spacecraft structures, a problem increasingly aggravated by the large size and reduced stiffness of modern spacecraft structural designs. The CSI analysis and design methods were developed to avoid interactions while maintaining spacecraft performance without exceeding structural capabilities, but they remain largely unvalidated by hardware experiments or demonstrations, particularly in-space flight demonstrations. One recent proposal for a low cost flight validation of CSI technology is to demonstrate active damping augmentation of the Space Shuttle Remote Manipulator System (RMS). An analytical effort to define the potential for such an active damping augmentation demonstration to improve the structural dynamic response of the RMS following payload maneuvers is described. It is hoped that this study will lead to an actual inflight CSI test with the RMS using existing shuttle hardware to the maximum extent possible. By using the existing hardware, the flight demonstration results may eventually be of direct benefit to actual Space Shuttle RMS operations, especially during the construction of the Space Station Freedom.


The Bianchi type-III cosmological model for a cloud string in the presence of bulk viscosity and magnetic field are presented. To obtain the determinate model it is assumed that there is an equation of state ρ = kλ and the scalar of expansion is proportional to the shear scalar θ∝σ, which leads to a relation between metric potentials B = mCn. The physical and geometric aspects of the model are also discussed. The model describes a shearing non-rotating continuously expanding universe with a big-bang start. In the absence of magnetic field, it reduces to the string model with bulk viscosity that was previously given in the literature.


The operation of a satellite power system (SPS) involves the conversion of solar energy into electrical energy with the aid of facilities carried by a geosynchronous satellite, the transmission of the obtained energy to earth in the form of microwave radio frequency energy, and the conversion of the energy received on earth into dc current for distribution into the network. Attention is given to questions concerning suitable microwave radiation density, details of space transportation for the construction of the SPS, and suitable approaches for the transformation of the solar energy into electric energy. It appears that a Rankine cycle using cesium as the main working fluid and a steam bottoming cycle might have advantages over a Brayton cycle concept considered earlier. In the area of solar photovoltaic concepts GaAlAs cells have advantages over silicon cells related to lighter weight, efficiency, and resistance to space radiation. The required amount of gallium seems to become available.


The computer simulation was performed in the potassium nitrate electrolyte solution using molecular dynamics method.The simple points charged(SPC) three-site model was adopted for H_2O molecule,the potassium ion was treated as hard sphere,and a rigid four-site model was adopted for the nitrate ion.During the simulation,both coulomb long-range interactions and L-J interactions were considered,and the coulomb long-range interaction was calculated using the EWALD summethod.The results show that the absolute value of water-water interaction energy increases with the increase of ionic concentration,which relates to the increase of the order degree.The higher concentration of the solution is,the higher order degree of dipole tropism is,and much more water molecules are attached to ions.


Physiotherapy is a medical profession offered to individuals in order to regain Movement to the maximum, develop and maintain functional capabilities at all stages of a person's life, Physiotherapy involves the combination of both physical and psychological well-being factors Many studies was done around supporting well-being interior design These studies dealt with an individual aspect of Wellbeing and do not link its various aspects,so The study came to address the problem of the lack of comprehensiveness application aspects of physical and psychological Well-being in physical therapy spaces interior design,Where traditional rehabilitation facilities do not provide patients with suitable environments for physical or mental Recovery, by isolating them in closed static spaces, The results of the research provide a good understanding of the factors, communication with nature and the dynamic spaces in the interior Design of physical therapy spaces, and provide a scientific reference for the operators and designers of these facilities as well as researchers interested in this field.


A new class of 4-deoxy-4-([4-substituted-1-piperazinyl], [4-morpholinyl] and [4-(perhydrol, 4-thiazin-4-yl)])-2,3-anhydrolyxopyranosides (3a-g and 6a-g) were synthesized from epoxy triflate moities 2 and 5 and 4-substituted piperazines, morpholines and perhydro-1,4- thiazines, respectively, to test their antibacterial activity. The characterized series of new compounds was tested in vitro against E. coli ATCC11229, S. aureus ATCC6538 and C. albicans SATCC10231.


The article reveals the algorithm for evaluating the research value of individual causality theories of serial crimes. Within the framework of various research schools, several main directions have been formed, explaining the reasons for the existence of serial crimes. For the most part, these theories are persuasive in both theoretical and empirical aspects, which makes the explanation of their large number problematic. The result of the study was an analysis of the strengths and weaknesses of biological theories of causality of serial crimes. In the conducted research, the following general scientific methods were used: analysis, synthesis, system-structural. The following private scientific methods were used in the study: biographical analysis, statistical analysis, comparative-historical method, expert assessment. The factors determining the content of the obtained knowledge about the personality of the offender are singled out: objective patterns that predetermine the nature of the object under study; the level of scientific knowledge necessary for the cognition of the object under study; the social order of the society; academic traditions; the research potential of the scientist. Among the factors by which it is expedient to determine the value of the theory of causality of serial crimes, the following criteria of analysis were assigned: the content of the theory; the typical image of a serial criminal resulting from the content of the theory; theoretical consistency and value; practical value and scope; empirical validity; strengths of the theory; weaknesses of the theory; political and doctrinal bias; the current state and development prospects. These criteria were used in the content analysis of a group of biological theories of causality of serial crimes.


In 1988, Warren Lee May has asked in the Proceedings of the American Mathematical Society the following: Let G be an abelian group whose p-component G p is simply presented andlet F be a field of char F = p > 0. Then whether the F-isomorphism FH ≅ FG for any group H implies that H p ≅ G p ? The first actual positive answer isgiven by us in 1997 again in these Proceedings for the particular case when length G p < Ω. Here we shall establish an elegant positive solution of the question when length G p < Ω2 but only over the field of p-elements F p , utilizing a new criterion for simply presentedness with length Ω in the terms of summable p-groups.


Nonlinear refractive index of the intracavity air is a problem. We review how the negative phase shift achievable from cascaded nonlinearities can cancel the positive phase shift from air to support 210-W average output power. © 2019 The Author(s)


Purpose: Gold standard to predict survival and stratify patients for risk-adapted therapy in diffuse large B-cell lymphoma (DLBCL) is the international prognostic index, although it does not consider the molecular heterogeneity of DLBCL. Deregulation of cyclin E (CCNE) is a strong predictor of poor prognosis in some neoplastic diseases. In tumor cells, it induces chromosomal instability with an increased rate of aneuploidy/polyploidy. Experimental Design: We analyzed in this retrospective study the prognostic value of immunohistochemical CCNE expression on a validated tissue microarray containing 101 de novo DLBCLs and, in 9 cases, the CCNE-induced chromosomal instability as assessed by cytometry. Results: Forty-six of 98 evaluable DLBCLs expressed CCNE in a mean proportion of 20 ± 29% of tumor cells; 38 cases expressed CCNE in ≥20% of tumor cells. CCNE-positive samples were aneuploid compared with near tetraploidy in CCNE-negative cases. Multivariate analysis showed CCNE expression in ≥20% of tumor cells to be an international prognostic index–independent, Adriamycin-based treatment-independent, and BCL2-independent prognostic factor for poor disease-specific survival. CCNE expression in ≥80% of tumor cells was associated with dismal short-term prognosis. CCNE expression in ≥50% of tumor cells emerged as an independent predictive factor for standard CHOP treatment resistance. Conclusions: CCNE expression assessment is easy on paraffin-embedded tissue. The high prognostic value of CCNE expression in DLBCL may be the basis for future prospective trials. In addition, a high CCNE expression hints at the presence of a possible target for individualized cancer therapy.


This paper focuses on developing the constitutive models for metal materials under cyclic loading that include thermal loads. Nonlinear isotropic hardening, linear kinematics hardening and a nonlinear combined hardening model are developed separately by using finite element method (FEM). Hardening parameters are obtained from the test data, and the exponential model is used to simulate the nonlinear data curves. Bauschinger effect is considered in the combined hardening model under cyclic hardening and the numerical results are presented to verify the accuracy and convergence of the program.


In this article, I introduce and evaluate the use of messy map interviews (MMI). Based on messy situational maps, MMI is an interview tool I have developed to facilitate understanding of elements pertinent to interviewees. I present and evaluate how the tool contributes to interview studies that aim to describe and analyze elements pertinent to interviewees. This is done by use of an exemplar of working with MMI, exploring parental decision-making about HPV vaccination. Based on the results, the study shows that MMI can help keep qualitative research loyal to what interviewees ascribe relevance to. Furthermore, the tool can potentially help nuance the analysis of how elements are understood by interviewees. The article concludes that MMI can be a useful mapping tool that keeps interviewees' perspectives in focus in interview studies.


The article discusses the properties of color in prose. Unlike a lyric work, prose comments on the use of color when expressing creative ideas. In the prose context, the static and dynamic manifestations of colors are given. The dynamic manifestation of colors in context is evidenced by examples of the repetition of the same color and the emergence of the primary color through its counterparts. It is also shown that the ratio of color to words and paragraphs in the context determines its importance in the expression of an artistic idea.


Circulation. 2019;139:146–147. DOI: 10.1161/CIRCULATIONAHA.118.037670 146 Tze-Fan Chao, MD Gregory Y.H. Lip, MD Shih-Ann Chen, MD In Response: We thank Aldaas et al for their comments regarding our recently published article on stroke prevention in very elderly patients (≥90 years of age) with atrial fibrillation (AF).1 We agree that the patient number treated with non-vitamin K antagonist oral anticoagulants (NOACs) in our study was small (n = 978), especially for those treated with apixaban (n = 60). In Taiwan, dabigatran was introduced in June 2012, rivaroxaban in February 2013, and apixaban in June 2014, and therefore patient numbers treated with apixaban were limited during our study period (years 2012–2015). We appreciate the enthusiasm of Aldaas et al for apixaban, and their comment that our results may not be generalized to the worldwide practice because they consider that apixaban is "widely prescribed." However, apixaban is not necessarily the most commonly prescribed anticoagulant in every country, and warfarin is still widely used globally.2 Also, we did not aim to focus on the comparisons of any specific NOACs to warfarin. Compared with warfarin, apixaban was associated with less major bleeding, less total bleeding, and less intracranial hemorrhage among patients aged ≥75 years.3 Therefore, if more patients in the NOAC group of our study were treated with apixaban, an even lower risk of major bleeding or intracranial hemorrhage could have been observed, which could further strengthen our conclusion that NOACs perform better than warfarin even among the very elderly AF population. Most importantly, in our study, only 3.9% of patients ≥90 years of age received warfarin in the era without NOACs, and the proportion was 16.1% (7.1% with warfarin and 9.0% with NOACs) in the era with NOACs. The increment in the prescriptions of oral anticoagulants, especially for NOACs, demonstrates how the introduction of NOACs, as a more convenient and safer choice, could substantially change the stroke prevention landscape among very elderly AF patients. Ultimately, stroke prevention is the cornerstone of AF management, and should be offered to patients with ≥1 stroke risk factors,2 as part of the holistic approach to improve outcomes in AF patients.4,5


The fluid mechanics associated with the interface between two fluids, and in particular air and water, is of obvious importance in applications such as remote sensing, and the characterization of the environment. In remote sensing applications interfacial dynamics play a role in determining signatures in the radar, infrared, and visible wavelengths of the electromagnetic spectrum. These dynamics also play an important role in the determination of the interfacial flux of heat, mass, and momentum at the air-sea interface. In particular, accurate estimation of carbon dioxide flux and aerosol production has a direct bearing on our ability to predict climate change. Here we will discuss the current progress that has been made in applying direct numerical simulations (DNS) to some of these problems. We will illustrate the use of DNS to study the relatively simple case of a flat interface subject to shear and an outgoing heat flux.


As part of a pilot project started in 2004, Larry Faudskar set out to see whether a telephone-based medication therapy management (MTM) service could be run for clients scattered across the nation.

Faudskar, area vice president of clinical management for CVS Caremark helped create the test program


Summary Rate of liver phosphorylase activity is decreased in fasted, adrenalectomized rats. Cortisone acetate administered at levels of 5, 2.5 or 1.25 mg/100 g body weight increased this activity above that of controls, the latter dosage only slightly above control level. Since glucose-6-phosphatase activity is also reported to be increased it is suggested that these 2 enzymatic effects may represent response to increased production of glucose precursors from peripheral protein.


Are Muslims especially prone to large-scale political violence? From Montesquieu to Samuel Huntington, prominent modern analysts of politics have regarded Muslims as unusually inclined to strife. Many other observers have portrayed Islam as a peace-loving faith and Muslims as largely pacific.Yet scholars still lack much hard evidence on whether a relationship between Islam and political violence really exists. Precious few studies adduce empirical evidence on whether Islamic societies are actually more or less violent. This article assesses whether Muslims are more prone to large-scale political violence than non-Muslims. The authors focus neither on terrorism nor on interstate war. Instead, they investigate large-scale intrastate violence. The article makes three contributions. First, it offers useful data on Islam and political strife. Second, it investigates whether Muslims are especially violence prone. Relying on cross-national analysis, the authors find no evidence of a correlation between the proportion of a country's population that is made up of Muslims and deaths in episodes of large-scale political violence in the postwar period. Third, the authors investigate whether Islamism (the ideology), as opposed to Muslims (the people), is responsible for an inordinate share of the world's large-scale political violence. They find that Islamism is implicated in an appreciable but not disproportionate amount of political violence.


Background; Cardiac injury is a prevalent complication and is associated with worse prognosis in COVID-19 patients. The increased cardiac workload resulting from respiratory failure and hypoxemia is a common mechanism of cardiac injury and the right ventricle may bear the brunt of its impact. The aim of the present study was to determine the incidence and prognostic value of RV dysfunction in COVID-19 patients admitted to ICU using conventional echocardiography parameters.Patients were subjected to full history taking, and clinical examination, Computed Tomography of chest was done for all patients to assess severity of lung infiltration, all patients received standard treatment according to Ministry of Health and Population COVID19 treatment protocol recommendations. Echocardiographic assessment was done to all patients.The mean age of the patients was 61.10±9.64years (range 42-80years).There were 36 (60%) male and 24 (40%) female. The non-survivor group consisted of 28 patients (46.7%) and survivors consisted of 32 patients (53.3%). There was statistically significant association between mortality and RV function  regarding TAPSE, FAC%, RV basal diameter and EPAP. We concluded that in COVID-19 patients, RV function must be assessed and its prognostic importance recognized. RV dysfunction is not only a symptom of high pulmonary pressures, but it also contributes to cardiac insufficiency.


We present the physical properties of the semi-detached Algol-type eclipsing binary Y Cam based on high resolution spectra obtained using the Bohyunsan Optical Echelle Spectrograph. This is the first spectroscopic monitoring data obtained for this interesting binary system, which has a δ Sct-type pulsating component. We obtained a total of 59 spectra over 14 nights from 2009 December to 2011 March. Double-lined spectral features from the hot primary and cool secondary components were well identified. We determined the effective temperatures of the two stars to be Teff,1 = 8000 ± 250 K and Teff,2 = 4629 ± 150 K. The projected rotational velocities are v1sin i1 = 51 ± 4 km s−1 and v2sin i2 = 50 ± 10 km s−1, which are very similar to a synchronous rotation with the orbital motion. Physical parameters of each component were derived by analyzing our radial velocity data together with previous photometric light curves from the literature. The masses and radii are M1 = 2.08 ± 0.09 M⊙, M2 = 0.48 ± 0.03 M⊙, R1 = 3.14 ± 0.05 R⊙, and R2 = 3.33 ± 0.05 R⊙, respectively. A comparison of these parameters with the theoretical evolution tracks showed that the primary component is located between the zero-age main sequence and the terminal-age main sequence, while the low-mass secondary is noticeably evolved. This indicates that the two components have experienced mass exchange with each other and the primary has undergone an evolution process different from that of single δ Sct-type pulsators.


The hypothesis that freshwater tidal wetlands act as sinks for heavy metals was tested using sewage sludge applied biweekly from March to October 1981 at low treatment (25 g m−2 wk−1) and high treatment (100 g m−1) levels. No differences in aboveground macrophyte standing crop were found except in June when high and low treatment sites had significantly higher (p=0.05) standing crops than control sites. Except for chromium, metal standing stocks in the vegetation on treatment sites did not increase as a result of sludge application. The March litter had significantly higher (p=0.05) concentrations of chromium, copper, lead, and nickel at all sites than the October vegetation, but only high and low treatment litter chromium levels were significantly higher (p=0.05) than control litter. When sludge application terminated in October, the top 5 cm of soil at the high and low treatment sites had retained, respectively, 47 and 43% of the cadmium, 53 and 28% of the chromium, 52 and 0% of the copper, 51 and 0% of the zinc, 31 and 0% of the lead, and 0 and 0% of the nickel applied; only cadmium (15 and 46%, respectively) and chromium (12 and 28%, respectively) were still retained the following March. Thus, freshwater tidal wetlands can retain significant quantities of heavy metals associated with sewage sludge. The vegetation and litter play minor roles while the soil plays a major role in heavy metal retention.


Statistical analysis of signal recordings at 10 cm wavelength has given the following results. The distance dependence of the half-hour signal median F_{m} over a sea path corresponds to a scattering parameter which is approximately inversely proportional to the height. Between F_{m} and the surface value of M a correlation coefficient of 0.62 is found, and between F_{m} and the dew point 0.55. A unit increase of M seems to be followed by a signal increase between the limits 0.3 and 0.8 db. The fading range, as defined between the 10 per cent and 90 per cent of time levels, is 12-14 db, and the fading frequency mostly about 2 c/s for a 300 km path. Over a 260 km land path the pulse broadening was normally 0.1-0.2 \mu s which corresponds to a scattering parameter varying inversely as the first to second power of the height. A severe pulse distortion caused by selective fading is found to be very common. Some other propagation characteristics are also discussed.


Five(±)2-phenyl-2-alkyloxy-ethanols were synthesized via reactions of alcohol with styrene oxide using sulfuric acid resin D-72 as a catalyst.Thier structures were characterized by(~1H NMR,) IR and GC-MS.Tha catalyst can be reused 8 times.


Preliminary charts are presented based on two years of data, to demonstrate the geographic distribution over Sweden of the annual amounts of Na, Cl, K, Ca, NH 3 -N and NO 3 -N brought to the surface of the earth by precipitation. The ratios of these total amounts to the total amounts of Na deposited during the same time interval are shown to possess systematic geographic distribution patterns. Comparisons are made between these ratios and the corresponding quantities in sea water. The investigation is now being resumed to provide additional data from a larger number of stations and for longer time periods. DOI: 10.1111/j.2153-3490.1954.tb01121.x


My thesis relates on the investigation of a family of inorganic nanoparticles with non-centrosymmetric crystal structure, known as harmonic nanoparticles. It treats both fundamental and application aspects. While most of the works on the nonlinear properties of micro- and nano-structures have addressed the generation of distinct signals, such as second or third harmonic, I demonstrate that the combination of harmonic nanoparticles with dual output lasers can enable the simultaneous excitation and detection of multiple emission orders, including several harmonics and signals stemming from various sum and difference frequency mixing processes. The strong optical responses remain conserved when the harmonic nanoparticles are embedded in biological media, opening the way to multi-functional applications, as shown in this thesis, such as photo-triggering, localized photo-damage and opto-poration.


1 BOKU, Department of Sustainable Agricultural Systems, Division of Livestock Sciences (NUWI), Gregor-Mendel-Strasse, 1180 Vienna, Austria, e-mail: firstname.lastname@example.com 2 Same address as 1, e-mail: firstname.lastname@example.com 3 Qualitas AG, Chamerstrasse 56, Ch-6300, Zug, Switzerland, e-mail: firstname.lastname@example.com 4 Same address as 3, e-mail: email@example.com 5 Department of Animal Science, Faculty of Agriculture, University of Zagreb, Svetošimunska cesta 25, 10000 Zagreb, Croatia, e-mail: firstname.lastname@example.com 6 Same address as 1, e-mail: firstname.lastname@example.com ABSTRACT In current study, we estimated local genetic ancestry for Swiss-Fleckvieh dairy cattle population using two alternative approaches implemented in LAMP and MULTIMIX software. Swiss-Fleckvieh is a composite descending from Simmental and Red Holstein Friesian. Illumina BovineSNP50 Beadchip data for 485 animals were used. Genetic ancestries averaged across admixed animals indicated a high correlation of individual admixture at global levels (0.99), yet the correlation between genetic ancestries averaged across 7914 windows (5 SNPs each) was 0.55. The highest correlations of window-wise estimates were along chromosomes 2, 5, 12, 15, 21, 27 and 29 (≥0.80) and the lowest was −0.71 on chromosome 24. Based on LAMP results, a region on chromosome 13 (46.3–46.7 Mb) and three adjacent regions on chromosome 18 (18.8–19.2, 20.1–25.7 and 23.9–25.7 Mb) passed the threshold based on deviation from normal distribution of local ancestries assuming 1000 independent segments. Regarding MULTIMIX, another region on chromosome 22 (9.3–10.3 Mb) was significant. Although estimates from both programs are comparable at the global levels, there was considerable difference at the local levels.


The features of alpha-linolenic acid metabolism in the peripheral blood of pregnant women of III trimester and in the homogenate of placentas of parturient women with the exacerbation of herpes-virus infection depending on IgG antibodies titer to the virus of simple herpes of 1 type have been studied in this work. It was found out that pregnant women who suffered from the exacerbation of herpes-virus infection during gestation had a decrease of alpha-linolenic acid concentration in plasma of the peripheral blood by 35% and in membranes of erythrocytes by 42%. At the same time in the homogenate of placentas of the parturient women who suffered from the exacerbation of herpes-virus infection during pregnancy there was a decrease of alpha-linolenic acid content. The most significant changes were observed at IgG antibodies titer to the virus of simple herpes of 1 type 1:12800. The revealed dysbolism of alpha-linolenic acid in herpes-virus infection may lead to a poor production of protective eicosanoids synthesized from acids of omega-3 family.


In this work, we first develop a general mesoscopic multiple-relaxation-time lattice Boltzmann (MRT-LB) model for the two-dimensional diffusion equation with the constant diffusion coefficient and source term, where the D2Q5 (five discrete velocities in two-dimensional space) lattice structure is considered. Then we exactly derive the equivalent macroscopic finite-difference scheme of the MRT-LB model. Additionally, we also propose a proper MRT-LB model for the diffusion equation with a linear source term, and obtain an equivalent macroscopic six-level finite-difference scheme. After that, we conduct the accuracy and stability analysis of the finite-difference scheme and the mesoscopic MRT-LB model. It is found that at the diffusive scaling, both of them can achieve a fourth-order accuracy in space based on the Taylor expansion. The stability analysis also shows that they are both unconditionally stable. Finally, some numerical experiments are conducted, and the numerical results are also consistent with our theoretical analysis.


This paper is an attempt to extract useful thermodynamic information from the experimental activity of zinc in Zn-Bi binary liquid alloy at different temperatures. The molecular interaction volume model (MIVM) was adopted to calculate a number of temperature dependent thermodynamic functions, including activity, free energy of mixing, concentration fluctuations in the long-wavelength limits, and diffusion. The reasonable agreement of the modeled thermodynamic parameters with the existing experimental data verified that the MIVM is quite convenient and reliable in the assessment of the thermodynamic properties of binary liquid alloys. K e y w o r d s: Zn-Bi, thermodynamic properties, molecular interaction volume model


Different nitrogen level was used in the cultivation test of Yunyan 85,a specialty tobacco variety,to study the effects on quality and yield of Yunyan 85 and to provide the scientific basis for improvement of tobacco quality,yield and flavor and production.The results showed that the tobacco under 6.2 kg nitrogen/667m2 treatment(3.72 kg/667m2 for base fertilizer and 2.48 kg/667m2 for top application) had good aroma quality,aroma amount and taste,little offensive odor and irritancy and the best quality,and the yield,output value and ratio of first and middle grade tobacco were all higher than treatments with 5.2 kg nitrogen/667m2 and 4.0 kg nitrogen/667m2.


We propose algorithms for the synthesis of decentralized controllers with partial observation of infinite state systems modelled by Symbolic Transition Systems. We provide models of safe controllers both for potentially deadlock and deadlock free controlled systems. To obtain algorithms for these problems, we use abstract interpretation techniques which provide overapproximations of the transitions set to be disabled. Our tool SMACS allowed us to make an empirical validation of our methods and show their feasibility and eficiency.


Two-dimensional polyacrylamide gel electrophoresis (2D PAGE) followed by mass spectrometry (MS) is the most widely used method of protein resolution and identification. But it exist shortcomings. In this paper introduce some novel methods for protein resolution and identification,including the methods by high-liquid chromotography,capillary isoelectric focusing,capillary electrophoresis or 1D and 2D microcapillary chromotagraphy.