This article investigates a generalised solution approach for transient viscoelastic flows employing consistent dynamic boundary conditions. Such a procedure vaunts three key properties independence of reference frame, problem dimension and constitutive equation type. Three different boundary condition protocols have been investigated, two transient and one steady, through a time-dependent incremental pressure-correction formulation with a hybrid finite element/finite volume scheme. These procedures are compared and contrasted through application to pressure-driven start-up flow in 4:1 planar rounded-corner contractions for two fluid models, Oldroyd and pom-pom. Some novel differences are highlighted in the dynamic evolution of flow structure and the impact upon stress generation, as a consequence of protocol, whether steady or transient, under flow-rate or force-driven control. Overshootundershoot kinematics observed under any particular flow protocol have been mutually linked to the precise boundary conditions imposed. Under flow-rate controlled protocols, large oscillations are stimulated in pressure, which may disturb computational tractability. Comparatively, the evolution of force-driven flow can provide considerably smoother development patterns in pressure, with largest attached vortices and strong oscillatory vortex structure features. Specifically under transient flow-rate control, some distinct complex flow features have emerged, including reversed flow, followed by vortex detachment and reattachment. For pom-pom SXPP-fluids and force-driven protocol, transient flow development is observed to be relatively smooth and non-oscillatory at a Weissenburg number of unity. At larger levels of Weissenburg number, transient overshoots have been detected in characteristic variables of stress and molecular backbone-stretch. In addition, Weissenburg number continuation to steady-state, has been shown to disconnect the dynamics between velocity and stress, which prevents highly-elastic localised regions from developing.


Simple Summary The anticancer drug doxorubicin is widely used for the treatment of malignant tumors, including colon, breast, and ovary cancers. However, prolonged use of doxorubicin causes heart damage, ranging from changes in the structure and function of heart cells to heart failure, the condition in which the heart does not pump enough blood. As this problem affects the quality of life and survival of cancer patients, solutions to it are urgently needed. This study demonstrates that Chrysanthemum morifolium extract, an extract of the purple chrysanthemum flower, reduced the heart damage caused by doxorubicin by suppressing cell death in heart cells and heart failure in an animal model. As Chrysanthemum morifolium has been eaten since ancient times, the extract from this functional food is likely to be safe in clinical application, potentially allowing patients to receive the well-established anti-cancer benefits of doxorubicin without the side effect of heart damage. Abstract It is well known that the anthracycline anticancer drug doxorubicin (DOX) induces cardiotoxicity. Recently, Chrysanthemum morifolium extract (CME), an extract of the purple chrysanthemum flower, has been reported to possess various physiological activities such as antioxidant and anti-inflammatory effects. However, its effect on DOX-induced cardiotoxicity is still unknown. An 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT)assay revealed that 1 mg/mL of CME reduced DOX-induced cytotoxicity in H9C2 cells but not in MDA-MB-231 cells. A TUNEL assay indicated that CME treatment improved DOX-induced apoptosis in H9C2 cells. Moreover, DOX-induced increases in the expression levels of p53, phosphorylated p53, and cleaved caspase-3,9 were significantly suppressed by CME treatment. Next, we investigated the effect of CME in vivo. The results showed that CME treatment substantially reversed the DOX-induced decrease in survival rate. Echocardiography indicated that CME treatment also reduced DOX-induced left ventricular systolic dysfunction, and a TUNEL assay showed that CME treatment also suppressed apoptosis in the mouse heart. These results reveal that CME treatment ameliorated DOX-induced cardiotoxicity by suppressing apoptosis. Further study is needed to clarify the effect of CME on DOX-induced heart failure in humans.


The utility model provides a gravity circulation type air conditioner end device which comprises a housing, a first heat exchanger positioned in the housing and a pipe line communicated with the first heat exchanger, wherein the upper end and the lower end of the housing are separately provided with a top blast tuyere and a bottom blast tuyere; the first heat exchanger is positioned in the upper space of the housing, and the first heat exchanger is separately connected with cold and heat source through the pipe line. The utility model is characterized in that a second heat exchanger is arranged below the first heat exchanger, and the second heat exchanger is connected with the cold and heat source through the pipe line. The gap between the first heat exchanger and the second heat exchanger can be so infinitesimal, and thus the first heat exchanger and the second heat exchanger are integrally connected to be a heat exchanger which has the same height to the housing as far as possible. The heat exchange area in vertical direction of the air conditioner end device of the utility model is increased, and thus the chimney effect between the cold / hot air is more visible. The utility model is suitable for refrigerating and heating.


We derive deep I band luminosity functions and colour-magnitude diagrams from HST imaging for eleven 0:2 0:4 that are not encountered locally. Surface brightness selection eects preferentially inuence the detectability of faint red galaxies, accounting for claims of evolution at the faint end.


Introduction Mercury is long known as a common environmental contaminant. In methylated form it is even more toxic and the methylation process is facilitated by microbial activities. Methyl mercury easily crosses cell membrane and accumulates in soft tissues of fishes and finally biomagnifies with increasing trophic levels. Natural variations in the isotopic composition of mercury have been reported and such variations have emphasized mass dependent fractionations, while theory, and laboratory experiments indicate that mass-independent isotopic fractionation (MIF) effects are likely to be found as well. This study focuses on the MIF of mercury isotopes in the soft tissues of fishes.


The aim of the present study was to evaluate the prevalence of active and passive smoking during pregnancy and its association with sociodemographic indicators, as well as perinatal and postnatal outcomes in newborns. Methods: This cross-sectional study was comprised of 431 pairs of mothers/ newborns. The study variables were: preterm birth, birth weight, oral mucosal lesions, sociodemographic indicators and smoking data. We collected data from medical records and through a self-administered questionnaire answered by mothers. A pediatric dentist examined the newborns for oral mucosal lesions. Bivariate and multivariate logistic regression models were used to evaluate the association between active and passive smoking and the other variables (α=5%). Results: The prevalence of active (9.5%) and passive smoking (4.2%) during pregnancy was low. Active smoking was statistically associated with low birth weight (OR: 2.4; 95%CI:1.1-5.3), lower schooling level (OR: 0.2; 95%CI:0.1-0.5) and mothers aged ≥36 years old (OR: 4.9; 95%CI:1.2-20.0). Passive smoking was not statistically associated with the other variables. There was no association between active or passive smoking during pregnancy and premature birth and oral lesions of the newborn. Conclusions: The prevalence of active and passive smoking were low. Active smoking was associated with low birth weight, maternal age and mother's schooling, suggesting a social influence of smoking behavior among a population with a lower educational level. There was no association between active and passive smoking and prematurity and oral lesions of the newborn


A device (100, 200) for collecting blood comprising: a body defining a receptacle (111, 211) sized to accommodate a tube (130, 230) recogidade blood, the body having a first open end and a second end supporting a needle (134), the needle (134) a proximal end (134a) extending into the receptacle (111, 211), and unaestructura retainer (120, 220) extending into the receptacle (111, 211) configured pararetener of releasably to the tube (130, 230) for collecting blood into the receptacle (111, 211), elque retaining structure (120, 220) includes at least one actuating member ( 122, 222) I elasticodispuesto on an inner surface (134, 224) of the body, the at least one actuating member (122, 222) elastic first (124) and second (126) ends, wherein at least one of the ysegundo first ends (124, 126) is secured to the inner surface (113, 224) of cu Erpo, caracterizadoporque a central portion of at least one actuating member (122, 222) elastic tilts haciadentro from the inner surface into the receptacle (111, 211) for engaging and retaining maneraliberable tube (130, 230) blood collection.


Spin-wave excitations in reentrant spin-glass (RSG) materials have been a controversial issue for a long time. In one group of materials, spin-wave stiffness constant D and spin-wave amplitude A s decrease as temperature decreases toward the spin-glass transition temperature in accordance with the decrease of magnetization. In another group of materials, the temperature variations of D and A s are opposite to those observed in the former group. The coexistence of two kinds of spin-waves has been observed in the RSG alloy Fe 65 (Ni 0.866 Mn 0.134 ) 35 . Temperature variations of D and A s for each spin-wave are similar to those of each spin-wave observed in the two groups of materials. The origin of the two kinds of spin-wave excitations observed in different groups of RSG materials is attributed to the presence of spin-waves in finite-size magnetic clusters and in an infinite ferromagnetic network.


This research aims to illustrate the characteristics of illegal transports of e-waste as a transnational environmental crime flow. It looks at the environmental problems at the basis of its criminalization: what actors are involved, what the nature of the phenomena is and what its impact, harm and vulnerabilities are. This will provide meaning to the second goal of our research which focuses on the governance of transnational environmental crime flows. The aim is to map governance nodes and networks and pay attention to different actors involved, to their interactions and potentially different finalities. We try to answer to these research goals by means of a case study research into illegal transports of e-waste. This presentation focuses on the characteristics of this phenomenon (goal 1), and briefly discusses preliminary results about its governance (goal 2).


The potential of new technologies that have been developed to support greater teacher effectiveness has increased, but, teachers/lecturers at higher education institutions do not use such technology enough in developing new methods of instruction. This is possibly because of the frustration experienced in slow equipment delivery and setting it up each time they want to use it. Too often, hardware and facility improvements are funded without the resources necessary to help lecturers make significant changes in courseware and teaching methods. There is too much reluctance on the part of lecturers to use instructional media as a way of improving teaching and learning. It is further acknowledged by this paper that, today, the diversification of technologies makes it possible to reach a new stage, making the integration of these new media essentials: the Internet, cyberspace, multimedia, hypermedia, and so on. The current width of this evolution, undoubtedly, calls for an urgent response to the problems raised by the use of educational media. Moreover, the particular characteristics of these new media, the digital whole, addresses new questions such as: what teaching scenarios are relevant and innovating? What is the impact of these media on methodologies and the organization of the learning and teaching institution? L'éducation des médias éducatifs dans l'enseignement supérieur. Les nouvelles technologies ont été développées pour soutenir une plus grande efficacité des enseignants mais l'on constate que ceux-ci ne s'appuient pas suffisamment sur ces technologies pour développer de nouvelles méthodes et de nouveaux usages pédagogiques. Trop souvent le hardware et les services sont financés sans que le soient aussi les mesures d'accompagnement susceptibles d'entraîner chez les enseignants des modifications significatives dans leurs méthodes d'enseignement. Il y a donc une certaine résistance de leur part À utiliser les nouveaux médias éducatifs afin de développer l'enseignement et l'apprentissage. L'évolution des médias actuels fait surgir de nombreuses questions telles que : quels sont les scénarios pédagogiques pertinents et innovatifs ? Quel est l'impact de ces médias sur les méthodologies, sur l'organisation des apprentissages et des systèmes de formation. Die Integration pädagogischer Medien in der höheren Bildung. Neue Technologien wurden entwickelt, um die Effektivität in der Bildung zu unterstützen. Man stellt jedoch fest, dass Lehrkräfte an höheren Bildungsinstitutionen diese Technologien nicht genügend einsetzen, um neue pädagogische Methoden zu entwickeln. Finanzielle Mittel für Hardware und weitere Einrichtungen werden häufig bereitgestellt, jedoch ohne die notwendigen Ressourcen, die den Lehrkräften bei der signifikanten Veränderung ihrer Lehrmethoden helfen sollen. Es existiert somit eine gewisse Abneigung seitens der Lehrkräfte, die neuen Medien zur Verbesserung ihrer Unterrichtsqualität einzusetzen. Die gegenwärtige Entwicklung der neuen Medien werfen somit Fragen wie diese auf : Welche Bildungsszenarien sind relevant und innovativ ? Welche Auswirkungen haben diese Medien auf die Methodik und die Bildungsinstitutionen ?


Abstract:Spatial descriptions in Alciphron's Letters convey meaning even as they reinforce the Athenocentric view of the collection. This article considers the production of space in the Letters and how Alciphron uses the figure of the courtesan to expand the perspective of the collection to include the broader Hellenistic world. Although Alciphron's courtesans are closely tied to Athens, Book 4 contains several examples of correspondence that are marked as crossing the boundaries of Attica. In addition, a spatial reading of the epistolary exchange between Menander and Glycera reveals a latent tension in the collection between Athens and Alexandria as competing cultural centers.


Collaborative inference helps robots to complete large tasks with mutual collaboration in edge-assisted multi-robot systems. It is challenging to provide trusted edge collaborative inference in the presence of malicious nodes. In this article, we propose a blockchain-based collaborative edge knowledge inference (BCEI) framework for edge-assisted multi-robot systems. First, we formulate the inference process at the edge as the collaborative knowledge graph construction and sharing model. Second, to guarantee the trust of knowledge sharing, an efficient knowledge-based blockchain consensus method is presented. Finally, we conduct a case study on the emergency rescue application to evaluate the proposed framework. The experiment results demonstrate the efficiency of the proposed framework in terms of latency and accuracy.


Whether writing a report for work, school, or publication, citing references is often a drudgery that most of us prefer to avoid. The good news is that there are software solutions that make citation notations and bibliography creation easy. The software solutions allow the user, while writing a paper, to create a database with all of the criteria necessary for citing commonly used resources such as journal articles, books, and Web sites. When the paper is done, a click of the mouse will insert the citations in the marked spot and create a reference list according to the selected format, for example, American Psychological Association (APA) or MLA. These reference databases are called personal bibliographic managers (PBMs) or a personal reference manager. Microsoft Word 2007 (Microsoft, Redmond, WA) for the PC and Word 2008 for the Apple Mac (Apple Computer, Cupertino, CA) have added a PBM as one of their new features. The purpose of this article was to explain how to use these Word PBMs. Instructions are provided for Word 2007 with corresponding instructions for Word 2008 in parentheses. Limitations of the Word PBM and alternative solutions are also discussed.


The opportunities to understand human-mobility have increased significantly of late with the rapid adoption of wireless devices that report locations frequently. In this work1, we utilize one such rich data-set comprising of nationwide call data records from several million users to analyze and understand their location patterns. We define a location pattern as the set of locations visited by a user, which roughly speaking, can be considered to be the footprint of the user. Such an analysis is useful since it allows insight into aspects such as the range covered by a user, general direction and major routes of travel, characterization of geographic areas etc.,. These in turn are useful inputs for network planning, traffic planning and mobility models. We propose a systematic methodology that utilizes geometric structures like the Minimum Area Rectangle, line segmentation and clustering techniques to extract meaningful information for location patterns and apply it to our large data-set. Based on this we report on aspects such as the size and orientation of footprints, length of major routes as well as characterize and compare locales based on movement patterns. Finally, we identify some key features of location patterns that can be modeled very well with a single statistical distribution, the Double Pareto LogNormal (DPLN) distribution regardless of locale.


Using a simple model, we calculate the transport properties of a one-dimensional easy-plane ferromagnet in the presence of an in-plane magnetic field. The model incorporates the combined effects of a magnetic field gradient and a temperature gradient acting on a gas of solitons and spin waves. Suggestions are made for experiments capable of measuring these effects in materials such as ${\mathrm{CsNiF}}_{3}$ and (${\mathrm{C}}_{6}$${\mathrm{H}}_{11}$${\mathrm{NH}}_{3}$)${\mathrm{CuBr}}_{3}$. We also discuss their use as another type of probe for solitons.


OBJECTIVE:To evaluate the curative efficacy of methotrexate combined with total glucosides of paeony for juvenile rheumatoid arthritis(JRA).METHODS: 61 JRA cases were randomly assigned to either control group(n=30) receiving methotrexate [(0.25-0.8)mg·kg-1] once a week orally plus brufen modified release capsule(fenbid) 0.6-1.2 g daily in two divided oral doses or treatment group(n=31) receiving add-on total glucosides of paeony 0.6 g t.i.d orally in addition to the drugs for control group for 3 consecutive courses of treatment,with one course of treatment lasting 4 weeks.The scores for clinical symptoms and signs,American College of Rheumatology response 70(ACR70),disease activity score and the total number of pain joints,the laboratory tests indices including blood sedimentation,rheumatoid factor,c-reactive protein,immunoglobulins(IgA,IgG and IgM) and the adverse drug reactions in both groups were recorded before and after treatment.RESULTS: At 4,8 and 12 weeks,the total response rates were 90%,94% and 100%,respectively for the treatment group,as compared with 87%,90% and 97%,respectively for the control group,showing no statistical difference between the two groups(P0.05).After treatment,the joint pain indices,morning stiffness time,ACR-70 response,disease activity score were statistically different between the treatment group and the control group at the same time point(P0.05);moreover,the differences in ESR,CRP and IgM were also significant between the treatment group and the control group at the same time point(P0.05);however,the adverse drug reactions were not statistically different between the two groups(P0.05).CONCLUSION: Addition of total glucosides of paeony to methotrexate resulted in proved efficacy and mild adverse reactions in treating patients with juvenile rheumatoid arthritis.


This paper develops the concept of the complex order-distribution. This is a continuum of fractional differintegrals whose order is complex. Two types of complex order-distributions are considered, uniformly distributed and Gaussian distributed. It is shown that these basis distributions can be summed to approximate other complex order-distributions. Conjugated differintegrals are an essential analytical tool applied in this development due to their associated real time-responses. An example is presented to demonstrate the complex order-distribution concept. This work enables the generalization of fractional system identification to allow the search for complex order-derivatives that may better describe real time behaviors.Copyright © 2005 by ASME


Background The environmental factors responsible for recent increases in the prevalence of asthma and atopic disease have been assumed to act after birth. Their possible effects on fetal immune development in utero have not been investigated systematically, although sensitization to allergens may occur before birth.


PROBLEM TO BE SOLVED: To provide both a mobile wearable advantage and a conventional fixed type advantage by combining a laptop computer and a mobile computer which has entire functions and is separable. SOLUTION: A base computer 6 (e.g. a laptop) has normal laptop components and a housing 9 for a mobile computer 10. Both computers 6 and 10 can separately and independently operate and also, can separately and independently communicate when they are separated. For instance, a removable keyboard and a monitor, i.e., a display are used as a means to be attached to a user's body. The entire components, i.e., the keyboard, the display, i.e., the monitor and a starting means 16 are designed to be replaced and used in the computers 10 and 6. COPYRIGHT: (C)1998,JPO


Lavas from Mahukona, a small Hawaiian volcano on the Loa trend, exhibit major and trace element abundance variations exceeding those in lavas from large Hawaiian shields, such as Mauna Loa and Mauna Kea. Mahukona lavas define three geochemically distinct groups of tholeiitic shield basalt and a transitional group of postsshield basalt. At 10% MgO the tholeiitic groups range from 9 to 12% CaO; such differences in CaO can reflect partial melts derived from garnet pyroxenite (low CaO) and peridotite (high CaO), but the negative CaO‐Yb (both at 10% MgO) trend formed by Mahukona lavas is inconsistent with this explanation. Within Mahukona lavas, radiogenic Nd‐Hf‐Pb isotopic ratios are highly correlated with each other; however, 87Sr/86Sr is decoupled from these radiogenic isotopic ratios. Rather, 87Sr/86Sr is correlated with trace element abundance ratios involving Sr, and importantly, Mahukona lavas define a negative Rb/Sr‐87Sr/86Sr trend, implying that a Sr‐rich source component characterized by high 87Sr/86Sr is important in the petrogenesis of Mahukona lavas. We infer that this Sr‐rich source component is recycled ancient carbonate‐rich sediments. Intershield heterogeneity among Hawaiian shields also shows a negative Rb/Sr‐87Sr/86Sr trend. For example, Makapuu‐stage Koolau lavas have higher 87Sr/86Sr but lower Rb/Sr than Mauna Kea lavas. Consequently, we infer that a recycled ancient carbonate‐rich sedimentary source component is important in the Hawaiian plume. Although most lavas from Loa and Kea trend volcanoes define distinct fields in isotopic ratios of Sr, Nd, Hf, and Pb, the majority of Mahukona lavas have isotopic ratios at the boundary between the fields defined by Loa and Kea trend lavas. However, a subgroup of Mahukona shield lavas have Kea‐like isotopic and trace element signatures, an observation that can be explained by vertical heterogeneity in a bilaterally asymmetrical plume.


Electronic structures of Mg-doped LiCoO2 were studied both experimentally via electron energy-loss spectroscopy (EELS) and theoretically via ab initio calculations based on density-functional theory. The Co L2,3 edge and O K edge were employed to probe effects of Mg doping on the electronic structure of Co 3d and O 2p states. According to the EELS results, Co tends to be a mixed-valence state, and O becomes more closed-shell characteristic with Mg doping. Quantum-mechanical calculations are performed using a total-energy pseudopotential code, CASTEP. Density of states and partial density of states are calculated, which are consistent with EELS spectra. Both experimental and theoretical evidence of the change in the valence state of both Co and O are revealed. A charge balance mechanism in Mg-doped LiCoO2 is suggested.


Background Untreated patients with familial hypercholesterolemia are at increased risk of premature cardiovascular death. The primary aim of this study was to investigate whether this is also the case in the statin era. Methods and Results In this registry‐based study, 4688 male and female patients from the Unit for Cardiac and Cardiovascular Genetics (UCCG) Registry with verified molecular genetic diagnosis of familial hypercholesterolemia in the period 1992–2010 were linked to the Norwegian Cause of Death Registry. Standardized mortality ratios and 95% CIs were estimated. There were 113 deaths. Mean age of death was 61.1 years. Cardiovascular disease was the most common cause of death (46.0%), followed by cancer (30.1%). Compared with the Norwegian population, cardiovascular disease mortality was significantly higher in the UCCG Registry in all age groups younger than 70 years (standardized mortality ratio 2.29, 95% CI 1.65 to 3.19 in men and women combined; standardized mortality ratio 2.00, 95% CI 1.32 to 3.04 in men; standardized mortality ratio 3.03, 95% CI 1.76 to 5.21 in women). No significant differences were found in all‐cause mortality or cancer mortality. Conclusions Despite prescription of lipid‐lowering drugs, familial hypercholesterolemia patients still had significantly increased cardiovascular disease mortality compared with the general Norwegian population.


S U N W E N , A L S O K N O W N A S S U N Y A T S E N , W A S born in Hsiang-shan prefecture in Kwangtung. His ancestors had been farmers for generations. As a child Sun too followed his forebears' calling with plow and hoe. When he was thirteen, he went to be with his eldest brother, who had migrated to Hawaii and was regarded as one of the well-to-do. He went to an American school there55 and was converted to Christianity. This upset his brother, who forced him to return home, where he worked on the farm once again. He was then seventeen. But the local villagers now realized his ability as a student, and raised money to make it possible for him to go to Canton to study at a medical school.56 After a stay of one year there, he moved to Hong Kong just as the English opened Hong Kong Medical College, transferred to it, and studied there for five years. He graduated from the Medical College with a first-rate record, and then immediately moved to Macao, where he began to practice medicine. He became well-known and prosperous with his policy to treat the poor free of charge and charging the rich exorbitant fees. He was so successful there that jealous European physicians did their best to make things difficult for him. During his stay in Macao,


This chapter sets the scene by placing cabotage services within the context of the development of the EC Maritime Transport Policy from 1986 to 1992. It briefly considers Council Regulation 3577/92 and the relevant European Court of Justice (ECJ) case law, and focuses on the EC competition rules (Articles 81 and 82 EC Treaty). The chapter then describes the likely impact of these rules on cabotage services generally, given that these rules now apply to this type of maritime transport service. It discusses island cabotage with particular focus on the tension between ensuring that a degree of competition exists in this market and acknowledging the public service function of these maritime transport services. Finally, it explains generally the application of the EC State aid rules to the grant of compensation when public service obligations are imposed. Keywords: Council Regulation 3577/92; EC competition rules; EC Maritime Transport Policy; EC State aid rules; European Court of Justice (ECJ) case law; island cabotage; maritime transport service


In this paper, Principal Component Analysis (PCA) is performed on HRIRs grouped according to azimuth and covariance to improve distortion performance while reducing storage requirement. By further combining Balanced Model Truncation (BMT) using a joint optimization scheme, a virtual 3D sound synthesis scheme with low computation complexity, little storage requirement and efficient linear interpolation is proposed. A smaller model distortion is achieved as high PCA model error of contralateral HRIR is decreased by grouping PCA strategy.


The utility model relates to an insect prevention shell fabric composed of an lining, a surface layer and a yarn laying layer arranged between the lining and the surface layer, wherein the lining is natural fibre or artificial fibre, the surface layer is synthon multifilament and the yarn laying layer is mekralon monofilament or polyethylene fiber monofilament, and the lining, the surface layer and the yarn laying layer all include pesticide component. The fiber adopted by the insect prevention shell fabric can be recovered for spraying filament processing afresh and is low in cost, and the shell fabric made by the fiber has a good touch. The insect prevention shell fabric made in the utility model has good air permeability, strong capability of resisting insects such as mosquito, and lasting mosquito prevention effect.


For multi-variable control system of voltage and frequency of marine diesel engine generator set, multiple CMAC neural networks (NN) controllers are designed and applied in system control according to principle of mapping connection and learning rule of CMAC NN. The CMAC NN control algorithm is provided with ability of fast learning rate on line. In control realizing process, the inverse dynamic model of object control system was obtained by multiple CMAC NN through learning. This model is a general approach model. The simulation results of the responses of generator load testing indicated that the quality is well in coordinate between two CMAC NN control loops.


A recording apparatus may comprise a recording head which has an ejection surface, and a wiping device configured to move in a wiping direction. The wiping device may comprise a wiper and a wiper holder. The wiping device may comprise a cam mechanism configured to support the wiper holder and change the height of the wiper holder, such that the wiper is positioned at a contacting height when the cam mechanism is moving in the wiping direction, and such that the wiper is positioned at a separation height when the cam mechanism is moving in the retracting direction. The wiping device may comprise a guide mechanism. The wiping device may comprise a moving device configured to move the wiper and the wiper holder together with the cam mechanism by moving the cam mechanism selectively in either the wiping direction or a retracting direction.


This research aims to analyze the effect of profitability, interest rates, liquidity, and solvency on insurance gross premium in Indonesia. The financial ratios studied are Return on Assets, Current Assets Ratios, and Debt to Equity Ratio as independent variables and demand for insurance services as the dependent variable. The data in this study used secondary data for five years (2012-2016), to analyze this study using multiple linear regression analysis with the data used is panel data which then carried out hypothesis testing with F test, T test, and Determination Coefficient (R- Square). The results of panel data regression analysis with the selected model are Fixed Effect Model which shows that the variables of profitability, level of liquidity, and solvency level have an influence on the demand for insurance services in Indonesia. While the interest rate shows no effect on the demand for insurance services in Indonesia. The results of this analysis show the following profitability (X1) 13.73, liquidity (X2) -2.4, solvency (X3) 2.28 and Interest Rate (X4) -0.83. While the value for the coefficient of determination (R-Square) is 0.87 or 87%. This shows that the variable capability of profitability, interest rates, liquidity, and solvency in explaining the demand for insurance services in Indonesia is 87%. Keywords: Financial Ratio, Gross premium


The overall introduction introduces the general problem of town development and attempts to define town planning in industrialised countries and in developing countries. A preliminary chapter is devoted to the dynamics of town planning and its negative effects in morocco. The first part - town planning : its scope and its limits - deals with the problem of property and with planning documents. The second part considers urban administration against the background of de concentration and decentralisation. The analysis of these two issues leads to concrete proposals with regard to both urban planning and administration. Proposals are also put forward for the adoption of a property policy. The adaptation of town planning documents to the moroccan context, and for the elaborate links between these two components of town planning. With regard to urban administration, the shortcomings of the local structures make advanced decentralisation difficult. A proposal is therefore made for the increased use of "urban agencies", which contitute a kind of de-concentration as a transitory step leading to decentralisation.


Purpose

The purpose of this paper is to explore a new design for the journal of revolute joints that can improve the dynamic performance of 3D printed non-assembly mechanisms.

Design/methodology/approach

The design improves upon previous proposed designs that use drum-shaped journals in place of cylindrical ones. The authors introduce an innovative new worm-shaped journal. The authors also propose a systematic and efficient procedure to identify the best parameter values for defining the exact shape of the journal. Using three different mechanisms for the experiments, the paper constructs 3D computer-aided design (CAD) models using the design as well as cylindrical and drum-shaped designs. The parameters for the optimum geometry for each type of design are determined by dynamic simulation using the CAD system. Actual prototypes of the ideal designs are constructed using a commercial fused deposition modeling (FDM) machine for physical comparisons.

Findings

This paper shows that in simulations as well in physical models, the proposed design outperforms the previous designs significantly.

Research limitations/implications

This study was mainly focused on the FDM process, and the authors have not yet explored other processes. One limitation of this approach is that it requires the mechanism to be printed along the axial direction of the revolute joint.

Originality/value

This paper proposes a new design for the journal in 3D printed revolute joints. A clear advantage of the design is that it can easily be used to replace normal revolute joins in non-assembly models without affecting any other parts of the geometry. Therefore, with relatively little effort, the authors can print non-assembly mechanisms with improved dynamic performance.


Highly educated and demanding customers, complex business structures, rapidly changing technology, greater liability, and strong competition bring unprecedented pressures on the vegetable seed industry. An effective quality system involving all of the business functions (breeding, parent seed maintenance, production, processing, testing, seed treatment, packaging, marketing, and customer service) seems to be inevitable. The future of the seed business belongs to companies that can provide continuous supplies of high-quality seed with necessary support and technical services and can afford investment in a rapidly advancing technology.


objective:To investigate the effect of early enternal nutrition combined with parenteral nutrition on the body composition of SAP patients. Methods:30 ASP patients were divided into two groups randomly,treatment group and control group.The patients in treatment group were supported with early EN combined with PN.The patients in control group were supported with TPN.The skin-fold and the change of fat were measured.Isotope dilution technique was used to measure TBW,TBF,LBM,ICM,ECM. Results:The TBW、TBF、LBM、ICM、ECM、albumin、Hb、transferrin in treatment group showed no statistical difference from control group(P0.05).But,the count of lymphocyte in treatment group was higher than that in control group(P0.05). Conclusion:Early EN combined with PN has no significantly different effect on the body composition from TPN,but it can improve the immune state of ASP patients.


Offshore exploration for, and production of, hydrocarbons in the Arctic has potential for oil spills and oil-well blowouts, which in tum has significant potential for detrimental effects on Arctic marine wildlife (pimlott and others 1976; Geraci and St Aubin 1980, 1988; 0ritsland and others 1981; Stirling and Calvert 1983; Stirling 1988). In addition, considerable quantities of oil regularly enter the marine environment through ballast water and tank washing from ships (Neff 1988). Polar bears are likely to be im pacted by an oil spill within their habitat, through the oiling of fur, ingestion of oil from grooming, and by feeding on oiled seals or sea birds (0ritsland and others 1981; Stirling and Calvert 1983). However, it is not known if wild polar bears would avoid swimming in oiled leads or eating oil-coated prey (Stirling and Calvert 1983). We report two observations of free-ranging polar bears contacting petroleum products. In Hudson Bay, polar bears spend three to four months on land during the summer and fall because the sea icc melts (Stirling and others 1977; Derocher and Stirling 1990). On 24 August 1984, an 8 year old adult male polar bear was captured near Cape Churchill, Manitoba. A brown oily substance was found matted into tile fur on parts of the head, neck, and shoulders of the bear. Samples of the oiled hair were collected and analyzed using gas chromatography, which revealed the substance to be a refined lubricating oil. The exact type was not identifiable. The bear was fe-sighted on 22 October 1984, by which time a substantial amount of hair had fallen out along the shoulder and neck region (Fig. I). This was not due to hair moult, which occurs from May through August (Kolenosky 1987). In September 1988 this bear was re-captured and no damage was detectable, indicating that the effects were not permanent. Fur is important to polar bears for thermo-regulation (0riL,landI970) and this ability is advcrsely affected by oil contamination (Kooyman and others 1977; Hurst and 0rils!and 1982). Skin damage <Inti hair loss can occur in polar bears aflcrcontacl with crude oil undcrcxpcrill1cnta! conditions (0ritsland anel others 1981). While thc source of the refined oil this bcarcomaclcd is unknown, it resulted in hair los$ similar to that found from exposure to crude oils. No similar hair loss was recorded in sightings or several hundred other bears at the same time of year. On 7 October 1989 asub-aduh pol;:lrbearwas observed drinking hydraulic oil from a pail outside the Churchill Northern Studies CerHre, Cllurchill, Manitoba (C. Paddock, personal cornolUnication). The bear conSUrlled an /!liV


Route Guidance System is a technology developed for facing efficiently traffic problems in congested urban areas. Final goals of the authors' research include the development of an Expert System prototype in order to simulate an on-vehicle Information System behaviour with the following characteristics: (1) route choice according to the personal user criterion; (2) capability of managing sudden critical situations (congestion, accidents, work in progress) by showing real-time alternative routes on the surrounding network; and (3) route choice according to the on-board disposability of an Information System, perfectly updated about the road network conditions and other user services as parking availability. This report focusses on a methodology for the analysis of the behaviour of road users in selecting a route. The examination of a driver's choice regarding the accomplishment of a journey shows four main elements in the choice mechanism: (1) the time of choice; (2) the choice criterion; (3) the source of information; and (4) the information processing system. For the covering abstract of the conference see IRRD 866319.


ABSTRACT This essay suggests that Petrarch's canzoniere, rather than being an originator of a mode of literary erotics, is a reception and mediator of classical Latin love elegy. Taking its starting point from Catullus' searing erotic poems written to and about Lesbia, it investigates the evidence for reading Catullus as a source for Renaissance literary love, and considers the ways in which Catullan erotics shape the poetics of love in early sixteenth-century England. The first section clarifies Latin elegy's defining tropes and maps these onto Renaissance erotics. The essay then traces the transmission of Catullus to the Renaissance and the ways in which he was received by readers, commentators and writers. The generally-accepted position on Catullus in England is that Philip Sidney was the first to translate one of his poems into English, but this paper offers pressing evidence that Catullus had a hitherto underexplored position at the Henrician court. A close reading of Wyatt's 'Whoso List to Hunt' considers how framing this text with Catullus rather than just Petrarch reveals the complex intertextual dialogues in the poem. As well as elucidating an alternative model for Wyatt's erotics, the readings here provide a case-study in Wyatt's practice of imitatio.


Industrial and anthropogenic activities have made heavy metals ubiquitous in the environment, and humans are exposed to them in various ways (Wilson and Pyatt, 2007). Heavy metals such as Fe, Cu, Zn, and Ni are essential for proper functioning of the biological systems in plants and their deficiencies or excesses could lead to disruption of cells (Ward, 1995; Uwah, 2009). However, contamination of heavy metals in the ecosystem through water, soil, air and agricultural produce (and their consumption by humans) have been a great concern of health issues. Sources of heavy metal contamination in Abstract


Newer troponin assays provide high sensitivity and precision and are reported in a stratified manner by some laboratories. We sought to investigate the clinical impact of such reporting in the treatment of patients with suspected acute coronary syndrome (ACS).


Analytical models were developed and simulations of memory latency were performed for Uniform Memory Access (UMA), Non-Uniform Memory Access (NUMA), Local-Remote-Global (LRG), and Replicated Concurrent-Read (RCR) architectures for hit rates from 0.1 to 0.9 in steps of 0.1, memory access times of 10 nsec to 100 nsec, proportions of read/write access from 0.01 to 0.1, and block sizes of 8 to 64 words. The RCR architecture based on redundant inexpensive DRAM is shown to provide favourable performance over UMA and NUMA architectures for application and system parameters in the range evaluated. RCR outperforms LRG architectures when the hit rates of the processor cache exceed 80% and hit rates of replicated memory exceed 25%. Inclusion of a small replicated memory at each processor significantly reduces expected access time since all replicated memory READ access hits become independent of global traffic. For configurations of up to 32 processors, results show that latency is further reduced by distinguishing burst-mode transfers between isolated memory accesses and those which are incrementally outside the working set.


The present study aims to find out the awareness of Higher Secondary School English teachers on Multiple Intelligences. Each teacher needs to be aware of different forms of intelligences. The objectives of the study are to find out the level of awareness of Higher Secondary School teachers on Multiple Intelligences and to compare the awareness on Multiple Intelligences among Higher Secondary School teachers based on gender and locality. Survey method is used for collecting data from 150 higher secondary school teachers in Thiruvananthapuram District. A questionnaire on Multiple Intelligences was the tool used for collecting data. The major statistical techniques used for analysing data were percentage analysis and t-test. The study revealed that majority of higher secondary school teachers possess awareness on Multiple Intelligences at an average level and also there exists significant difference in the awareness of Multiple Intelligences among higher secondary school teachers based on their gender. It was also found that there is no significant difference in the awareness of Multiple Intelligences among higher secondary school teachers based on their locality. Awareness on Multiple Intelligences can change the way teachers teach and it is especially useful in supporting more student-centered approaches to instruction and in developing the Multiple Intelligences in students by means of promoting collaborative learning activities.


In this paper we use the Alexandrov Reflection Method to obtain a characterization to embedded CMC capillary annulus $\Sigma^2 \subset \mathbb{B}^3$. In especial, but using a new strategy, we present a new characterization to the critical catenoid. Precisely, we show that $\Sigma \subset \mathbb{B}^3$ being an embedded minimal free boundary annulus in $\mathbb{B}^3$ such that $\partial \Sigma$ is invariant under reflection through a coordinates planes, then $\Sigma$ is the critical catenoid. This work is part of the second author thesis which was written in 2019.


The fifth-generation (5G) mobile telecom network has been a focal point of research amongst the community in recent times. Features and characteristics like dynamicity (which enables the dynamic allocation of resources to stakeholders on a need basis), low latency, higher network capabilities etc., makes 5G attractive to telecom operators. But as is the case with any new technology, new threats have emerged and made their way into the ecosystem. Therefore, we have a need to evaluate these threats and evaluate the state of security of 5G deployments. Security metrics provide a pathway to quantitatively measure the security posture of an environment by taking these new threats into account. Existing literature contains a plethora of security metrics proposals designed for different system setups. We need to analyze if and how existing security metrics can be applied to a 5G environment. As such, this thesis aims to do a state-of-the-art survey to explore the diverse set of security metrics in literature, understand the process of deriving security metrics. We then employ this knowledge to investigate the factors that hinder the usage of existing security metrics in a 5G environment, identify solutions from existing academic proposals on how to address those factors, propose an adapted security metrics approach to address the multi-ownership nature of 5G and discuss the design and analysis of Argus-5, a tool designed to verify the feasibility of the adapted security metrics approach and simulate various scenarios.


Gibberellic acid (GA3) applied to Hedera helix L. cv. Baltica markedly enhanced branching; optimum treatment was 300 ppm applied twice on alternate weeks. The branching effect was evident only on growth occurring from buds maturing after treatment. When GA3 was applied to pruned plants secondary lateral shoot growth occurred. Application of 6-benzylamino-9-(tetrahydropyran-2-yl)-9H-purine (PBA) did not affect lateral growth.


Abstract Universities must strategically communicate agricultural science to effectively reach millennials skeptical of agricultural innovations and constantly assessing the credibility of online information. Universities are trusted information sources and must maintain credibility on social media platforms such as Twitter, used by millennials to receive and share information. Source credibility seeks to understand message source and recipient characteristics that influence recipients' perceptions of a source's expertise and trustworthiness. The purpose of this study was to explore differences in engagement when specific factors affecting source credibility were emphasized when communicating with millennials about agricultural science on Twitter. The purpose was accomplished by describing the level of engagement and the differences in engagement observed between perceived gender, race, and age of university scientists. Over seven months, researchers wrote press releases about published journal articles authored by two or more diverse, university-affiliated scientists. They published multiple tweets about each release, with the only difference being the scientists' headshots. Scientists were categorized as perceived male versus female, White versus Non-White, and older versus younger. Descriptive analysis of engagement metrics from 32 tweets found those with females performed better than those with males. Non-White scientist tweets performed better with the exception of engagement rate. Tweets featuring younger scientists received more engagement than older. The exploratory results implied tweets featuring young, Non-White females may elicit higher engagement. Future studies should examine if engagement metrics are correlated with source credibility dimensions. Strategically featuring diverse scientists in research communication may be utilized to build engagement in universities' social media.


Abstract Reasonable allocation of educational powers and expenditure responsibilities between central and local government is crucial to the development of education. The reason lies in the fact that local governments have relatively insufficient incentives to invest in education by using local fiscal revenues, while the central government, which pursues the maximization of the interests of the whole society, could promote education and other public services with spatial spilloves. The fiscal transfer payment has made up for the shortage of local investment in education. This paper uses 2010 census (micro data) and macro fiscal data to verify the effects above. Based on the year of birth and place, this paper constructs the proportion of fiscal transfers for compulsory education in the total fiscal revenue (local fiscal revenue and fiscal transfers) to reflect its structural effect. It is found that every 10% increase in the proportion of fiscal transfers brings at least additional 0.2 year of schoolings for local residents, and the effect of special transfer payments accounts for a larger share, among the three types of transfer payment. In the mechanism test, we find that transfer payment can effectively increase local education expenditure and produce an obvious structural effect. Based on this, in order to further improve the long-term educational performance of individuals, we believe that it is necessary to improve the incentive effect of the transfer payment system on common power and the division of expenditure responsibilities in the field of education.


Introduction When it comes to mental health, lawyers appear to be their own worst enemies. Research over the past several decades has identified that certain traits and characteristics correlate with success in law school and in the practice of law (Daicoff, 2004). Research has also identified that there is an unusually high incidence of distress and psychopathology (mental illness) amongst law students and lawyers, compared to the general population, and even other professions (Deveson, 2012). These findings have catalyzed the legal community to take action to try to improve the situation and outcome for law students and lawyers. They have also motivated researchers to try to pinpoint the cause of this phenomenon, in the hope of finding solutions.


Uninary levels of delta-aminolevulinic acid (ALA) were determined in 93 workers exposed to lead. Control groups were made up of 32 employees of the same factories of test group and of 24 patients with no history of lead exposure. In the first group, urinary concentration of ALA was 28.55 mg/1; it was 3.36 mg/1 in the second group and 2.98 mg/1 in the other control group. Differences between workers and controls were statistically significant.


By using the data of FHD vector proton precession magnetometer in the 1.0 min.sampling rate,we preliminary analyzed the anomalies of daily-variation spatial correlation before an earthquake occurred in this paper.Firstly,we reduced the influence of the phase difference of daily variation on the correlation caused by the disagreement of the longitude of the observatories by using delay technique,and found that the delay technique can extend the selecting range of the longitude of the reference observatories,which is considered one of the advantages the digital geomagnetic data of minutely value have.We also analyzed the influence of the short-period changes on the spatial correlation of daily variation and found that the influence of the hour-period on the spatial correlation is larger than the shorter period.


This journal explains the results of cohesion and coherence analysis in the current new news discourse in Indonesia published by Republika, Thursday 16 May 2019. The research uses descriptive methods by describing and explaining the results of the analysis found in the study. This research is a type of qualitative research because the results tend to be released and descriptive. the technique used in this study is to take data, data collection is done in two ways, namely listening and taking notes. This study found the results of the use of cohesion and and the use of coherence. Cohesion is the integration between the parts that are characterized by the use of language elements. Cohesion is divided into two parts, lexical cohesion and grammatical cohesion. Grammatical cohesion includes conjunction, reference, release, substitution. Lexical cohesion includes antonyms, synonyms, repetitions, metonymy, and hypomini. Whereas, cohorence is the relationship between elements one with the other elements so that it has an integrated meaning.


We read with interest the article by Thomas et al. on 'Combined effects of systolic blood pressure and serum cholesterol on cardiovascular mortality in young (<55 years) men and women'. The authors have observed a dramatic increase in cardiovascular disease and coronary heart disease risk in young (especially men) French people due to an associated elevation of high systolic blood pressure and high serum cholesterol. We would like to draw attention to the fact that hypertension and serum cholesterol also enhance the risk of stroke, which is the second most common cause of death worldwide. The authors have recorded a significant proportion of mortality induced by high systolic blood pressure and high serum cholesterol. However, the possibility of a cause and effect relationship between stroke and mortality due to these factors has not been considered in this study. Several studies have shown that treatment of systolic hypertension in the elderly can prevent stroke and cardiovascular events [2]. It appears that few studies have covered the effect of high systolic blood pressure and high serum cholesterol in younger patients. We strongly consider that had the authors taken this point into consideration during their study, it would have benefited the scientific community much more. Additionally, the information pertaining to the role of certain risk factors, such as smoking, has not been addressed clearly. For example, the earlier study, in which patients with 6·7 mmol . l 1 of plasma cholesterol and a borderline systolic blood pressure of 140 mmHg were prone to coronary heart disease and cardiovascular disease, is almost similar to patients with a high cholesterol (9·1 mmol . l ) or a systolic blood pressure of 240 mmHg, if the former patient smokes five cigarettes per day. Therefore, the relationship of borderline elevation of two or three risk factors with serious elevation of one factor, as detailed above, deserves more elucidation. It is documented that isolated systolic hypertension is a good predictor with which to indicate the proneness of cardiovascular disease in those who are above 60 years of age. To the best of our knowledge, information on this is not available in younger patients. In the present study from the provided data, it is difficult to analyse the presence of any case having isolated systolic hypertension. Consideration of this point during analysis also would have strengthened the scientific content. Letters to the Editor 1887


Recirculating ball (RCB) steering gear with four-bar linkage steering system is widely used in commercial vehicles with rigid front axle and over slung suspension owing to their architectural arrangement. The usage of RCB steering gear with four-bar linkage steering system with underslung suspension is not commercialized globally due to complexity of packaging suspension and steering linkages. Few automotive OEMs have studied and implemented Y link steering system in place of four-bar linkage steering system for underslung suspension arrangement. Y link steering system has got its inherent disadvantages such as higher bump steer, poor self-centering, complex linkages, more number of parts and less tire life. Further this arrangement is comparatively costlier than four-bar linkage steering system owing to their higher number of parts. In this paper, an extensive analysis has been made to implement the four-bar linkage steering system for underslung suspension vehicle. In this arrangement, the track rod (one of the links of a four-bar linkage system) is packaged above the leaf spring unlike in vehicles with overslung spring. Due to this unique arrangement, there exists some challenges in critical parameter optimization and packaging which are addressed in this paper. A mathematical model was developed to arrive at optimum steering and suspension geometry inorder to reduce the Ackerman error for better tire life and improve vehicle handling characteristics. By solving this mathematical model, optimum hardpoints can be arrived to achieve less Ackerman error, lower steering effort, lower bump steer, better steering returnability and best in class tire life. The present paper shows a possible approach to define the optimized steering and suspension linkages from the existing complex geometry with underslung suspension. This attempt is first of its kind in automotive industry and if commercialized successfully will go a long way in improving steering performance and cost savings for the vehicles with underslung suspension.


Making use of a class of 2D statistical face models known as active appearance models (AAMs), we investigate a technique for generating real-time animated avatars suitable for video gaming. We consider here a number of improvements of these models in order to make them more robust to varying environmental conditions, as well as to reduce the computational load such that to become adapted for real-time implementations.


We report the discovery of J1521−3538, a bright (V = 12.2), very metal-poor ([Fe/H] = −2.8) strongly r-process-enhanced field horizontal branch star, based on a high-resolution, high signal-to-noise Magellan/MIKE spectrum. J1521−3538 shows the largest r-process element overabundance in any known r-process-enhanced star, with [Eu/Fe] = +2.2, and its chemical abundances of 22 neutron-capture elements closely match the scaled solar r-process pattern. J1521−3538 is also one of few known carbon-enhanced metal-poor stars with r-process enhancement (CEMP-r stars), as found after correcting the measured C abundance for the star's evolutionary status. We propose to extend the existing classification of moderately enhanced ( ) r-I and strongly r-process enhanced ( ) r-II stars to include an r-III class, for r-process stars such as J1521−3538, with and , or times the solar ratio of europium to iron. Using cosmochronometry, we estimate J1521−3538 to be and , using two different sets of initial production ratios. These ages are based on measurements of the Th line at 4019 Å and other r-process element abundances. This is broadly consistent with the old age of a low-mass, metal-poor field red horizontal branch star. J1521−3538 likely originated in a low-mass dwarf galaxy that was later accreted by the Milky Way, as evidenced by its highly eccentric orbit.


AIM
Acinetobacter baumannii can cause sepsis with high mortality rates. We investigated whether glucose sensing might play a role in A. baumannii pathogenesis.

MATERIALS & METHODS
We carried out transcriptome analysis and extracellular polysaccharide determination in an A. baumannii clinical isolate grown on complex medium with or without glucose supplementation, and assessed its ability to induce production of inflammatory cytokines in human macrophages.

RESULTS
Growth in glucose-supplemented medium strongly enhanced A. baumannii sugar anabolism, resulting in increasing lipopolysaccharide biosynthesis. In addition, glucose induced active shedding of lipopolysaccharide, in turn triggering a strong induction of inflammatory cytokines in human macrophages. Finally, hemolytic activity was strongly enhanced by growth in glucose-supplemented medium.

CONCLUSION
We propose that sensing of exogenous glucose might trigger A. baumannii pathogenesis during sepsis.


In analyzing the background of the current development of graduate education in China, this article elucidates that vigorous development of graduate education is of strategic significance for the social and economic development of the country and for rejuvenating the country through science and education. Based on a discussion of the existing problems and the sources in this respect, this article points out that cultivation of the ability of creative thinking and research should be the kernel of graduate education. Centered a-round this kernel, a few measures and proposals are offered.


Article is devoted to the analysis of religious culture of Ural students in the system of higher professional education of Russia. Materials of two complex regional investigations in the problems of confessional behavior among students held by the authors in 2005-2012 in the Institute of Economics of the UB of the RAS in the given article. Sociologist revealed inconsistency of religious consciousness of students, ambiguity of motifs and causes of their participation in propaganda actions of Russian Orthodox Church, targeted to student audience.


Since the founding of the PRC,China's higher education administrative system has traveled a tortuous route from establishment to reform,from reform under the conditions of the traditional socialist planned economy to restoring order from chaos in the new period,and then from adapting to a socialist economy commodity to reform under a socialist market economy.It has experienced failures as well as successes.This paper surveys this historical process and highlights the intrinsic relations of reform.It sums up the experiences and lessons and their relevance for China's higher education administration reforms in the new century.


We revisit the exquisite archival radio data for the Type Ic supernova SN 1994I and present a revised model for the supernova (SN) radio emission and a pilot study that aims to constrain the rate of C-band radio transients within the face-on host galaxy, M51 (NGC 5194). We find that the temporal and spectral evolution of the SN 1994I radio emission are well fit by a synchrotron self-absorption model and use this to estimate physical parameters. We compute a pre-explosion mass loss rate of M ˙ = 3.0 × 10 − 5 M ⊙ ?> yr−1 for the progenitor, consistent with those observed from galactic Wolf–Rayet stars. Our model makes different assumptions for the dynamical model for the shockwave interaction than the model previously published by Weiler et al., but our M ˙ ?> is consistent with theirs to within errors and assumptions. Drawing from a subset of the archival radio observations from the Very Large Array collected for the monitoring of SN 1994I, we conduct a pilot study to search for previously unidentified transients. Data were primarily taken at a frequency of 4.9 GHz and are logarithmic in cadence, enabling sensitivity to transients with variability timescales ranging from days to months. We find no new transient detections in 31 epochs of data, allowing us to place a 2 &sgr; ?> upper limit of 17 deg−2 for the source density of radio transients above 0.5 mJy ( L ≳ 4 × 10 25 ?> erg s−1 Hz−1 at the distance of M51). This study highlights the feasibility of utilizing archival high-cadence radio studies of SN host galaxies to place constraints on the radio transient rate as a function of luminosity in the local universe.


After a careful analysis of the problem the study holds following reaso ns responsible for the growing menace: 1. Improper implementation of the Minimum Wages Act and non


Abstract : The dependence on beam energy and lattice geometry of the intensity of electrons diffracted from surfaces is evaluated using the inelastic-collision model. At energies below that of the second primary Bragg peak, qualitative features of the intensity profiles are related to the lattice geometry. Their quantitative features depend sensitively on the scattering from the surface layer. The first detailed interpretation of such profiles is proposed for the (100) face of tungsten. (Author)


The striped stem borer moth, Chilo suppressalis, has two major host plants; rice, Oryza sativa, and the water-oats, Zizania latifolia. It has been suggested that there is reproductive isolation between the populations feeding on rice (rice population) and water-oats (water-oats population). We compared the morphological characteristics of the two populations using multi variate analyses based on eight genital and ten non-genital traits in male adults. Body size differed between the two populations as shown previously. However the results of a principal component analysis (PCA) based on genital traits showed a proportional difference between the two populations, but not on the non-genital traits. This shows the existence of a morphological difference in the genitalia of male adults between the populations. We also conducted a discriminant function analysis (DFA) based on seven genital and five non-genital traits. The discriminant function obtained could classify the two populations with 94.3% accuracy. Another discriminant function using only four genital traits also could distinguish the two populations with 88.6% accuracy. DFA would be of use in the practical forecasting of occurrence.


To examine how body mass index (BMI) and change in BMI are associated with mortality in old (70–79) and very old (≥80) individuals.


Ultrasmall (∼2 nm) copper(I)- and silver(I)-doped CdS and core/shell CdSe/CdS quantum dots (QDs) stabilized by Cd(II) complexes with mercaptoacetate anions and ammonia were produced in aqueous solu...


Mating of Sitotroga cerealella (Olivier) was disrupted by the synthetic sex pheromone, ( Z,E )-7,11-hexadecadien-1-ol acetate, in 3 different enclosed environments. The effectiveness of the pheromone as a disruptant depended on both population and dose. Higher doses were more effective than lower doses over a range of population densities, and all doses were most disruptive at low population densities.


Anterior segment dysgenesis (ASD) is involved in not only the structural and morphological abnormalities of anterior segment but also the changes of metabolism and physiology of ocular drainage system.Patients with ASD often have elevated intraocular pressure then resulting in development of glaucoma.Gene mutations related to eyeball development are important reasons for these abnormalities.Moreover,the signal transduction pathways of these gene products are intercommunicated with each other to form a complicated network.We reviewed the study of anterior segment development related genes.


Lessie Williams received the inaugural REACH Lark Galloway-Gilliam Award for Advancing Health Equity from the Centers for Disease Control and Prevention in August. Recently retired, Williams previously served as executive director of the nonprofit organization Highland Haven in Portland, Oregon, where she created youth violence prevention programs, expanded access to culturally-relevant mental health services and launched culturally-tailored health education programs to promote healthy behaviors.


Many studies are carried out to explore factors affecting students' performance (academic achievement). The purpose of this research is to identify and examine factors that affect students' performance at UiTM Kedah. A set of questionnaires was distributed to the respective respondents. Several factors that being discussed in this research are demographic, active learning, students' attendance, involvement in extracurricular activities, peer influence and course assessment. The data is analyzed using descriptive analysis, factor analysis, reliability testing and Pearson correlation of Statistical Package for Social Sciences (SPSS). After conducting factor analysis, all variables are grouped into five factors which exclude peer influence. The researchers found that four factors are positively related to students' performance that are demographic, active learning, students' attendance and involvement in extracurricular activities. However, course assessment was found to be negatively related to students' performance. Further research on students' performance can be conducted on a larger scale including all UiTM to obtain better result. KEYWORDS: student performance, active learning, attendance, extracurricular activities, peer influence, assessment.


The decline of the Cherry Point Pacific herring stock (CPPHS) has been a puzzle of the upper Puget Sound. In this study, age‐structured population modeling was used to examine the timing and scale of the dynamics of Pacific herring stocks throughout the Puget Sound region. The intrinsic rate of increase and equilibrium age structure was calculated and forecast models were created for the stocks found in Puget Sound. We demonstrate that the causative agent for the decline of the CPPHS and the collapse in age structure existed in the 1974–1975 timeframe. Similarly, Puget Sound Pacific herring stocks at Squaxin Pass, Discovery Bay, and Port Gamble also demonstrate a collapse in age structure as seen in CPPHS during that same period. The data from the mid 1980s to 2006 demonstrate that all stocks share the collapse in age structure. The conclusion is that the causative agent had to affect these stocks at a scale corresponding to the Puget Sound; the effect has lasted over a 30‐year period, and was essentially simultaneous across the region. Forecast modeling of the stocks indicates that given current conditions none of the stocks are likely to show an increase in population size. The results were used to examine the likelihood that the Eastern Pacific decadal oscillation, disease, and persistent organic pollutants are singularly or in concert the causative agents. A research program is suggested to determine the cause(s).


Abstract A pure resistance electrical analogue is used to assess the elastic toe displacements that occur in a longitudinal fillet weld subjected to a uniform shearing intensity throughout its length. The result is compared with measured values obtained from an experimental investigation of fillet weld deformations. Conclusions are drawn concerning the behaviour of a stiff welded junction.


In this paper, we introduce a novel regularization technique for the spectral partitioning of a mesh that relies on a efficient preconditioning of the associated graph Laplacian. The regularization is obtained by leveraging on fractional order Sobolev norms obtained with integral operators and by linking the Laplacian and the operators with suitably chosen Gram matrices that connect the underlying discretization spaces. The numerical results support the developed theory when applied to some of the realistic examples arising in Computational Electro-magnetics applications.


where A,B,Cj are linear, continuous and symmetric operators on a real Hilbert space H. A and B are positive definite, B is completely continuous and the operators Cj are positive semidefinite and have finite dimensional range. The poles σj of problem (1.1) are assumed to be positive and ordered by magnitude: 0 < σ1 < σ2 < · · · < σp. Problems of this type govern eigenvibrations of plates with elastically attached loads, and mechanical vibrations of fluid-solid structures, e.g. In [1], [6], [7] the second author studied iterative projection methods of JacobiDavidson and of Arnoldi type for the rational sparse matrix eigenproblem (1.1). These methods determine eigenvalues quite efficiently, however, it was an open question whether all eigenvalues in a given interval (in particular between consecutive poles) had been found or not. The question can be easily answered for intervals (μ1, μ2] such that no pole σk is contained in [μ1, μ2] considering the parameter dependent linear eigenproblem


Simple Summary Colitis-associated cancer (CAC) are associated with the development and progression of colorectal cancer (CRC). And Fusobacterium nucleatum (F. nucleatum), a major pathogen involved in chronic periodontitis, may play an important role in CRC progression. Though the importance of F. nucleatum in CRC has attracted attention, its exact role and related mechanism in CAC progression remain unclear. We investigated the effects of F. nucleatum in both in vitro and in vivo colitis models induced with dextran sodium sulfate (DSS), a well-known colitis-inducing chemical, on the aggressiveness of CAC and its related mechanism. This study showed that F. nucleatum accelerates the progression of CAC cancer by promoting epithelial–mesenchymal transition (EMT). This study provides a novel mechanism involved F. nucleatum in the development of colitis-associated CRC. Abstract Recently, it has been reported that Fusobacterium nucleatum, a major pathogen involved in chronic periodontitis, may play an important role in colorectal cancer (CRC) progression. In addition, inflammatory bowel diseases such as ulcerative colitis and Crohn's disease represent major predisposing conditions for the development of CRC, and this subtype of cancer is called colitis-associated cancer (CAC). Although the importance of F. nucleatum in CRC has attracted attention, its exact role and related mechanism in CAC progression remain unclear. In this study, we investigated the effects of F. nucleatum in experimental colitis induced with dextran sodium sulfate (DSS), which is a well-known colitis-inducing chemical, on the aggressiveness of CAC and its related mechanism in both in vitro and in vivo models. F. nucleatum synergistically increased the aggressiveness and epithelial–mesenchymal transition (EMT) characteristics of CRC cells that were treated with DSS compared to those in non-treated CRC cells. The role of F. nucleatum in CAC progression was further confirmed in mouse models, as F. nucleatum was found to significantly increase the malignancy of azoxymethane (AOM)/DSS-induced colon cancer. This promoting effect of F. nucleatum was based on activation of the EGFR signaling pathways, including protein kinase B (AKT) and extracellular signal-regulated kinase (ERK), and epidermal growth factor receptor (EGFR) inhibition significantly reduced the F. nucleatum-induced EMT alteration. In conclusion, F. nucleatum accelerates the progression of CAC by promoting EMT through the EGFR signaling pathway.


There are many nursing achievements to be proud of during these difficult times, despite ongoing challenges of the COVID-19 pandemic. Staffing shortages due to sickness and self-isolation are affecting many services, and the implementation of mandatory vaccination in care settings and hospitals has brought an additional raft of issues.


The invention discloses a method for preparing peptide used for the active feed by the bacteria and enzyme synergistic fermentation bean pulp. The method comprises the following steps of: preparing complex enzyme used for synergistic fermentation; preparing complex strain used for the synergistic fermentation; mixing and adding the complex enzyme and the complex strain into the bean pulp; blending the bean pulp with warm water; carrying out grading temperature-control fermentation on the bean pulp containing water; and post-processing materials formed after fermentation to obtain a finished product. Compared with the prior art, the method has the advantages that trypsin inhibitor is almost removed, big-molecule protein in the bean pulp is effectively degraded, and the actions of the microorganism and the enzyme are furthest cooperated.


Liquefaction of mixtures of an Illinois bituminous coal and a caustic lignin was studied. Reactions were conducted at an initial hydrogen pressure of 1.1 MPa and at a temperature of 375°C, in tetralin. The liquid product from the coal-lignin mixture contains a lower fraction of the undesirable benzene insolubles than the product for coal alone. Size-exclusion chromatography studies indicate that, with the coal-lignin mixture, the weight-averaged molecular weight for the overall liquid product is lower than the molecular weight obtained by reacting coal or lignin alone


Ca2+ inflow via store-operated Ca2+ channels was investigated in rings of rat tail and basilar arteries kept in serum-free organ culture, which is known to preserve the contractility of the vascular smooth muscle. After culture for 3–4 days, Ca2+ release from intracellular stores in response to caffeine (20 mM) was augmented 2- to 4-fold. Following depletion of intracellular Ca2+ stores by caffeine and thapsigargin (10 µM), addition of Ca2+ (2.5 mM) caused an increase in the intracellular Ca2+ concentration which was 2–3 times greater in cultured than in freshly dissected rings, and was not affected by verapamil (10 µM). In contrast, L-type Ca2+ channel currents were decreased by 20% after culture. While freshly dissected rings developed no or very little force in response to the addition of Ca2+ after store depletion, cultured rings developed 42% (tail artery) and 60% (basilar artery) of the force of high-K+-induced contractions. These contractions in cultured vessels were insensitive to verapamil but could be completely relaxed by SKF-96365 (30 µM). Store depletion by caffeine increased the Mn2+ quench rate 3- to 4-fold in freshly dissected as well as cultured tail artery, while there was no increase in freshly dissected basilar artery, but a 3-fold increase in cultured basilar artery. Uptake of Ca2+ into intracellular stores was twice as rapid in cultured as in freshly dissected tail artery. This study shows that organ culture of vascular smooth muscle tissue causes changes in Ca2+ handling, resembling the pattern seen in dedifferentiating smooth muscle cells in culture, although contractile properties are maintained.


Right © The Electrochemical Society, Inc. 2015. All rights reserved. Except as provided under U.S. copyright law, this work may not be reproduced, resold, distributed, or modified without the express permission of The Electrochemical Society (ECS). The archival version of this work was published in doi: 10.1149/2.0441509jes. J. Electrochem. Soc. 2015 volume 162, issue 9, D444-D448 Type Journal Article


Analysis of the behavior of an economic agent is one of the central themes of microeconomics. Right now, with the comprehensive increase in the amount of data and the expansion of the computing capabilities of personal computers, there is a need to implement methods of behavioral economics in the study of human behavior. In the course of this study, a survey was created aimed at identification of patterns of behavior of the modern consumer according to his selection criteria stores and reactions to questions based on Behavioral Economics theorems. Clustering the obtained results were performed using machine learning algorithms, after which the Random Forest classification algorithm was trained. According to the results of Silhouette analysis, K-means clusters were selected as the main ones for further modeling. TSNE algorithms, hierarchical and spectral analysis were used for additional visual representation. This study offers a tool for classifying customer preferences and analyzing current industry trends. A tool has been created to classify consumers of food retail chains in order to improve their "buyer's journey" and better understand their needs. The created tool for clustering and classification by machine learning methods can be used in business processes. To improve the result, it is necessary to choose a more representative sample, because used in this study consists of an average rationally thinking and knowledgeable individuals, which cannot be said of the average consumer not only among the older generation but also among the younger. Therefore, the next directions in the study may be to identify new ones behavioral trends in other industries; deepening understanding of food retail; use of geodata to improve analysis, etc. Potentially attractive the direction may be to add an assessment of the impact of network advertising on behavior consumers through semantics analysis and image recognition.


Electronic publication is the mixture of modern communication techniques, web techniques and multimedia techniques. Compared with the traditional printing document,it has many characteristics and advantages, it has shortcomings itself either. So the choice of the interview strategy should be paid more attention to when a library interview documents.


Regular perturbation is applied to the Manakov equation and motivates a generalized correlated phase-and-additive noise model for wavelength-division multiplexing over dual-polarization optical fiber channels. The model includes three hidden Gauss-Markov processes: phase noise, polarization rotation, and additive noise. Particle filtering is used to compute lower bounds on the capacity of multi-carrier communication with frequency-dependent powers and delays. A gain of 0.17 bits/s/Hz/pol in spectral efficiency or 0.8 dB in power efficiency is achieved with respect to existing models at their peak data rate. Frequency-dependent delays also increase the spectral efficiency of single-polarization channels.


Chiral tertiary amine-derived ionic liquid-supported squaramide was synthesized from available precursors and applied as an efficient organocatalyst for asymmetric Michael additions of β-dicarbonyl compounds to α-nitroolefins in the presence of water. Corresponding Michael adducts were generated under proposed conditions in nearly quantitative yield with high enantioselectivity (up to 99% ee). Useful precursors to pharmaceutically important chiral β-amino acids and anticonvulsant Pregabalin were conveniently prepared using the developed "on water" protocol. The catalyst is readily recoverable and reusable over 30 times without a significant decrease of catalytic reaction activity and selectivity.


Objective To discuss the diagnosis,treatment and prognosis of cutaneous and pulmonary amyloidosis.Methods The clinical manifestation,results of laboratory examination and treatment of one case of primary cutaneous and pulmonary amyloidosis were analyzed retrospectively and reviewed.Results The most common symptoms of the patient were reticularbromus moth patch,lichenification and nodule.His cutaneous biopsy specimens showed that homosphere eosinophilous substance deposited under dermal papilla and reticular layer and Congo red stain were positive.The computer tomography displayed nodule,fibriform streaks,high-density patching shadow and lymphadenopathy of mediastinum at lungs.The nodule of lungs biopsy specimens showed amyloidosis.Conclusion The mixed type cutaneous amyloidosis complicating rare pulmonary nodulous amyloidosis is seldom seen in clinic.Its diagnosis relies on pathology.There are no specific treatments so far,but the manifestation can be improved by antibiosis and anti-inflammatory.


Binary black-hole systems are expected to be important sources of gravitational waves for upcoming gravitational-wave detectors. If the spins are not colinear with each other or with the orbital angular momentum, these systems exhibit complicated precession dynamics that are imprinted on the gravitational waveform. We develop a new procedure to match the precession dynamics computed by post-Newtonian (PN) theory to those of numerical binary black-hole simulations in full general relativity. For numerical relativity NR) simulations lasting approximately two precession cycles, we find that the PN and NR predictions for the directions of the orbital angular momentum and the spins agree to better than $\sim 1^{\circ}$ with NR during the inspiral, increasing to $5^{\circ}$ near merger. Nutation of the orbital plane on the orbital time-scale agrees well between NR and PN, whereas nutation of the spin direction shows qualitatively different behavior in PN and NR. We also examine how the PN equations for precession and orbital-phase evolution converge with PN order, and we quantify the impact of various choices for handling partially known PN terms.


A method for recovering triethylamine from triethylamine hydrochloride aqueous solution comprises allowing calcium oxide and the triethylamine hydrochloride to react, and distilling at 50-150 DEC C to obtain the triethylamine; adding the calcium oxide into the collected triethylamine, refluxing under heating to remove water, and distilling to collect the triethylamine having water content smaller than 0.5%, distilling to obtain the triethylamine, separating solid from a turbid aqueous solution residual in a reaction kettle, adjusting the pH value of the aqueous solution to 7 with hydrochloric acid, and removing water to respectively obtain calcium chloride hexahydrate, calcium chloride dehydrate and anhydrous calcium chloride; and allowing the calcium oxide after drying the triethylamine and the triethylamine hydrochloride to react to obtain the triethylamine. Compared with the prior method for recovering the triethylamine from the triethylamine hydrochloride aqueous solution, the method has the advantages of simple operation, low price, high recovery rate, and no three wastes discharge.


Simple Summary In this paper we perform an introduction about pregnancy-associated cancer (PAC) and transplacental passage of antineoplastic agents. Furthermore, we describe therapeutic use and potential toxic effects of chemotherapeutic drug (alkylating agents, antimetabolites agents, anthracyclines, topoisomerase inhibitors, antimitotic agents, actinomycin-D, bleomycin) and targeted agents during pregnancy. This manuscript may be a useful and practical guide for the management of PAC, which is a challenge for clinicians that have to consider alike maternal benefits and fetal potential risks correlated to the antineoplastic treatment. Abstract The incidence of PAC is relatively infrequent among pregnant women. However, it has gradually increased in recent years, becoming a challenging area for clinicians that should take into account in the same way maternal benefits and fetal potential risks correlated to the antineoplastic treatment. None of the antineoplastic drugs is completely risk-free during the pregnancy, the timing of exposure and transplacental transfer properties influence the toxicity of the fetus. Despite the lack of guidelines about the management of PAC, several studies have described the use and the potential fetal and neonatal adverse events of antineoplastic drugs during pregnancy. We provide a review of the available literature about the transplacental passage and fetal effects of chemotherapy and targeted agents, to guide the clinicians in the most appropriate choices for the management of PAC.


PRECISION ROTARY DIVIDER PLATE AND METHOD FOR FORMING TEETH. PILOT ROTARY MOUNTED PLATE 12 ON BASE FIXED STRUCTURE 80 DOOR ON LOWER SIDE 30 INDOOR TOOTHED CROWN 34 TO ENHANCE CROWN DENTEE 62 FORMED ON A PISTON 44 CAN AXIALLY MOVE AND ROTATE IN A BORING 84 OF THE STRUCTURE 80 SOLIDARITY OF A CENTERING RING 40 CARRYING A CURVED CROWN 43 FOR GRANTING WITH A SECOND OUTER CURVED CROWN 64, CONCENTRIC IN THE FIRST 62 OF THE PISTON 44, WHEN THE PISTON IS SOLICITED IN THE EMERGENCY POSITION BY A PRESSURIZED FLUID. TWO ENGINES ARE RESPECTIVELY IN ROTATION PLATFORM 12 AND PISTON 44 TO OBTAIN ANGULAR RELATION DESIRED BETWEEN THE TRAY AND THE FIXED STRUCTURE, AS WELL AS A PUSHED PRECISION, OF THE ORDER, FOR EXAMPLE, OF 1000 OF MM, DIVISION ANGULAR. APPLICATION TO DIVIDER PLATES FOR MACHINING AND VERIFICATION OPERATIONS.


A BSTRACT : Efler (General Court, judgment of 10 May 2017, case T-754/14, Efler et al. v. Commission ) is the last in a stream of cases dealing with the European Citizens' Initiative (ECI). This Insight seeks to position Efler in the current narrative of ECIs taking into account the Commission's powers – as well as the boundaries thereto – to register an ECI, in the light of the case law of the General Court. Therefore, this Insight will be structured as follows. Firstly, it will offer an overview of the current state of affairs regarding ECIs, with a particular emphasis on the case law of the General Court concerning the registration stage of an ECI. Secondly, it will tackle the peculiarity of the Efler case, to the extent that the General Court focussed on the concept of legal act to implement the Treaty. Thirdly and in con-clusion, it will argue that Efler is a welcome development in the narrative of ECIs given that it could very well have a positive impact on the revision of Regulation 211/2011, making the registration procedure more citizen-friendly. However, the broad understanding of the notion of legal act offered by the General Court could even open the gates to a flow of unrealistic and unreasonable ECIs.


It is shown that previous astrophysical methods of dating the young pulsar in Vela, PSR 0833-45, have effectively given upper limits to the true age. A value of 5000-8000 yr is found here to be not inconsistent with all available observational data. The historical significance of such a young age is briefly discussed.


Since the days of Ross and Grassi the anophelines have received close attention of research Avorkers all over the tropics, but never in history was the pace of progress in the study of this group of insects developed such importance as during the last one and a half decade. A number of anophelines acts as vectors of malaria, one of the worst diseases of the tropical countries. Efforts were mostly directed in the past to study the systematics and biology of the insects as they came up, but any serious attempt to study their complicated life processes or ecology which is in fact linked up with intensive field observations in relation


• The findings from this study support our classroom data for textbook prepU versions which clearly demonstrate that progression through prepU mastery levels leads to better student outcomes (grades or NCLEX pass rates). I N T RO D U C T I O N Combining a formative assessment tool for instructors and an online quizzing and learning environment for students, prepU brings together best practices in learning, technology and assessment to provide a unique adaptive quizzing tool for students and instructors. Online quizzing allows students to study and learn using the mastery approach proposed by Bloom (1968). By allowing students to take quizzes, study, retake quizzes, study again and so on, students may benefit from some of the learning gains shown in mastery learning programs (Kulik, Kulik, & BangertDrowns, 1990).


Speech directed at infants and pets has properties that distinguish it from speech among adults (6). Some of those properties are potentially useful for language learning. By careful design of form and behavior, robots can hope to evoke a similar speech register and take advantage of these properties. We report some preliminary data to support this claim, based on experiments carried out with the infant-like robot Kismet (4). We then show how we can build a language model around an initial vocabulary, perhaps acquired from "cooperati ve" speech, and bootstrap from it to identify further candidate vocabulary items drawn from arbitrary speech in an unsupervised manner. We show how to cast this process in a form that can be largely implemented using a conventional speech recognition system (8), even though such systems are designed with very different applications in mind. This is advantageous since, after decades of research, such systems are expert at making acoustic judgments in a probabilistically sound way from acoustic, phonological, and language models.


FIELD: medicine, pharmacy. SUBSTANCE: invention proposes the drug that is the composition showing synergistic, biological, neurometabolic and providing cellular trophism and also etiopathogenic and homeostatic effects. Composition is developed on the basis of combination the following active components: (a) with respect to oxidative and catabolic stress: methionine with aminoethanolphenoxy acetates and/or aminoethylphenoxy acetamides; (b) with respect to anabolic stress: hydrooxopyrimidine carboxylates and/or oxopyrrolidine acetamides with potassium, zinc or lithium; (c) vasodilating and lipidemia normalizing preparations: nicotinic alcohol and/or acid or their derivatives with magnesium and iodine; (d) energy activating and (e) antitoxic compounds: aspartate, fructose, vitamin B 1 , vitamin B 6 , hydroorthophosphate and sulfate. Method of preparing the drug involves the following stages: (a) pharmaceutical preparing two complementary types of capsules or tablets with cover that are soluble in stomach and intestine being the latter have enterosoluble envelope; (b) prolonged release of vasodilating preparation from intestine-soluble standard dose. Invention provides emotional-affective stabilization and maintenance of human mental functions under stress conditions. EFFECT: improved method of preparing, enhanced effectiveness of drug. 7 tbl, 3 ex


Determination of the plasma concentrations of beta‐thromboglobulin (BTG), thromboxane B2 (TxB2) and platelet factor 4 (PF4) were made at the time of birth in 18 newborns and their respective mothers. Both groups show significant elevation of all these molecular markers, suggesting marked platelet activation. The elevated TxB2 levels in the newborn group, 25 ± 8 pg/ml, are compatible with a normally functioning and activated platelet prostaglandin pathway. Mode of delivery, vaginal or caesarean section, does not significantly influence the degree of activation in either group. Ultrastructural platelet examination did not reveal any morphologic differences between maternal and newborn platelets. There appears to be marked activation of the newborn and maternal platelet systems at the time of birth, and we postulate that this may explain in part the transient platelet dysfunction observed in newborns.


When deploying online homework in physics courses, an important consideration is how many tries learners should be allowed to solve numerical free-response problems. While on the one hand, this number should be large enough to allow learners mastery of concepts and avoid copying, on the other hand, granting too many allowed tries encourages counter-productive behavior. We investigate data from an introductory calculus-based physics course that allowed different numbers of tries in different semesters. It turns out that the probabilities for successfully completing or abandoning problems during a particular try are independent of the number of tries already made, which indicates that students do not learn from their earlier tries. We also find that the probability for successfully completing a problem during a particular try decreases with the number of allowed tries, likely due to increased carelessness or guessing, while the probability to give up on a problem after a particular try is largely independen...


Objective: To compare food consumption among individuals identified with or without orthorexia, and their differences in relation to the level of physical activity. Methods: A cross-sectional study was carried out with a sample of 59 adult individuals (30 women and 29 men), aged between 18 and 50 years, of both sexes. Participants were assessed and divided about level and type of physical activity (physically active: >150min of exercise per week). Presence of orthorexia was evaluated by ORTO-15 questionnaire, and food consumption was evaluated by a usual one-day recall. Statistical analysis was done by T-Student or Mann-Whitney U Test for comparison between groups with and without orthorexia. Comparison of data described as absolute and percentage frequencies was performed by chi-square. Results: The mean age of the sample evaluated was 31.2 ± 8.9 years. There was a prevalence of orthorexia of 78%, being higher in physically active individuals (86% versus 65%, p = 0.05). Individuals with orthorexia consumed more protein in relation to grams per day, kg, percentage of total energy value and kcal (p <0.05); and had lower intake of carbohydrates than the percentage of total energy value (p <0.05), compared to those without orthorexia. This pattern remained significant only in the physically active group. Conclusion: The results of this study suggest that orthorexia may be associated with physical exercise and eating behavior with higher intakes of protein and low carbohydrates.