Surface modification by ion implantation has been conducted to improve the tribological properties of a high-strength and high-fracture-toughness unidirectionally aligned silicon nitride (UA-SN). B + , N + , Si + , and Ti + ions were implanted into the planes parallel and normal to the grain alignment of the UA-SN with a fluence of 2 × 10 17 ions/cm 2 at an energy of 200 keV. The ion implanted UA-SN showed a dramatic improvement in wear resistance. For example, the specific wear rate of the Si + -implanted specimen in the direction parallel to the grain alignment was reduced to a value of 3 x 10 -10 mm 2 /N, equal to 1/20 of the unimplanted one. Cross-sectional transmission electron microscopy indicates the high wear resistance was attributed to the amorphous surface caused by the ion implantation.


As is known to us, visually induced motion sickness (VIMS) is often experienced in a virtual environment. Learning the visual attention of people with VIMS contributes to related research in the field of virtual reality (VR) content design and psychology. In this paper, we first construct a saliency prediction for people with VIMS (SPPV) database, which is the first of its kind. The database consists of 80 omnidirectional images and the corresponding eye tracking data collected from 30 individuals. We analyze the performance of five state-of-the-art deep neural networks (DNN)-based saliency prediction algorithms with their original networks and the fine-tuned networks on our database. We predict the atypical visual attention of people with VIMS for the first time and obtain relatively good saliency prediction results for VIMS controls so far.


Euphemisms are indirect ways of expression,they are the use of pleasant,mild or roundabout expressions in place of those blunt,harsh or direct ones.Euphemizing is a reflection of the mode of cognition and is concerned with the cognitive psychological activities of human beings.This paper is going to have a research on the generation of euphemistic effect of English euphemisms with the Figure-ground Theory and explore the understanding process of English euphemisms within the framework of Relevance Theory.It analyses the identification and understanding of English euphemisms in the daily communicative process and probes into the cognitive inference ability of human beings in the process of understanding of them.


The goal of the project was to design and implement an English word-list representation suitable for spell-checking in space-constrained environments. The compression algorithm was derived by statistically analyzing the word list. A compression ratio of 18p was achieved through a combination of prefix and suffix encoding. The compressed file can be randomly accessed by prefix marker positions. A simple spell-checker based on the encoding was implemented and tested in Java. Copyright © 2005 John Wiley & Sons, Ltd.


This paper proposes a circuit capable of incorporating buffered delays in the order of picoseconds. To study our proposed circuit in the profound way, we have also explored our proposed circuit using emerging technologies such as FinFET and CNFET. Comparisons between these technologies have been made in terms of different parameters such as duration of incorporated delays (pulse width) and its variability with supply voltages. Further, this paper also proposes a trigger pulse generator by utilizing proposed buffered delay circuit as its basic element. Parametric results obtained for the proposed trigger pulse generator match different application specific requirements. These applications are also mentioned in this paper. The proposed trigger pulse generator requires very low supply voltage (700 mV) and also proves its effectiveness in terms of tunability of pulse width of the generated pulses. The modeling of the circuit has been done using Verilog and the simulation results are extensively verified using SPICE.


Abstract. A monitoring station for suspended sediment transport is in operation in the Carapelle torrent since 2007. Continuous data are registered to investigate the relationships between suspended sediment concentration and water discharge in flood flows and to model soil erosion and sediment load at the watershed scale. The Carapelle is one of the main streams of Apulia region (Southern Italy); the rainfall regime is typically Mediterranean and the land use is largely represented by winter wheat, with a lower fraction of deciduous oaks, hardwoods, pasture and other land uses. The AnnAGNPS model was calibrated and validated at the event scale. Thirty-six events were used to estimate the performance of the model during the period 2007-2011. The model performed well in predicting runoff; the prediction capability of sediment load was also good. On the monthly and annual scale, the model showed a good prediction capability for runoff and satisfactory results for sediment load. Based on the current conditions of the watershed as a baseline scenario, the effectiveness of alternative management practices was also evaluated, with a focus on reduced tillage and conversion of cropland to forest. To identify feasible strategies, the latter was targeted only at the most erosion-prone areas, as detected by the model. The effect of vegetated streams and riparian buffers as natural traps increasing the in-situ sediment deposition was also considered.


One approach to designing structured low-density parity-check (LDPC) codes with large girth is to shorten codes with small girth in such a manner that the deleted columns of the parity-check matrix contain all the variables involved in short cycles. This approach is especially effective if the parity-check matrix of a code is a matrix composed of blocks of circulant permutation matrices, as is the case for the class of codes known as array codes. We show how to shorten array codes by deleting certain columns of their parity-check matrices so as to increase their girth. The shortening approach is based on the observation that for array codes, and in fact for a slightly more general class of LDPC codes, the cycles in the corresponding Tanner graph are governed by certain homogeneous linear equations with integer coefficients. Consequently, we can selectively eliminate cycles from an array code by only retaining those columns from the parity-check matrix of the original code that are indexed by integer sequences that do not contain solutions to the equations governing those cycles. We provide Ramsey-theoretic estimates for the maximum number of columns that can be retained from the original parity-check matrix with the property that the sequence of their indices avoid solutions to various types of cycle-governing equations. This translates to estimates of the rate penalty incurred in shortening a code to eliminate cycles. Simulation results show that for the codes considered, shortening them to increase the girth can lead to significant gains in signal-to-noise ratio (SNR) in the case of communication over an additive white Gaussian noise (AWGN) channel


This paper is devoted to the numerical modelling of transient exterior acoustics problems. The propagation of acoustic waves in waveguides is addressed. These systems can be decoupled into a series of scalar problems using the method of separation of variables. For each mode, high-order doubly asymptotic boundaries for the resulting scalar wave equation are proposed. This is based on a continued-fraction solution of the frequency-dependent modal impedance coefficient, which relates the modal pressure to the modal flux at the near field / far field interface. The continued-fraction solution is transformed into a series of linear equations in the frequency domain by introducing internal variables. This corresponds to a system of first-order differential equations in the time-domain, which fully represents the unbounded waveguide in a transient analysis. Numerical experiments demonstrate that both evanescent and propagating modes can be modelled with high accuracy. This leads to stable time-domain solutions, even for long-time simulations. Highly accurate representations can be achieved for arbitrarily high modes. The proposed method is used to study several transient acoustic wave propagation problems in waveguides.


With reference to the national standard The Usage of Numerals in Publications( 2011),the paper reviews the origins of the Chinese numeral "zero"and its different forms. It discusses problems in the application of the numeral "zero ",and provides corresponding solutions.


The article represents a short historical outline of creation and development of the music industry. It analyzes the prerequisites for shaping the music industry as well as the historical facts, which influenced the music industry development. The author outlines stages of the development and studies the influence on the music industry emergence of such inventions as book printing, sound recording, radio, cinematography and Internet. Special attention is given to the digital technology influence on music production and consumption.


Petri nets are a well-known formalism widely used in different application areas. Yet, the lack of adequate tools that can be integrated within engineering development frameworks are one major drawback. This paper identifies and justifies the characteristics of one class of Petri nets targeted for the modelling of automation systems and (networked) embedded systems, named as input-output Petri net (IOPT), and its representation using the Petri net markup language (PNML). The paper also presents a set of associated tools under development. This Petri net class, defined on top of the well-known place-transition Petri nets, is the common link across a set of tools under development, including a graphical editor, a state-space analyser for the verification of properties, conflict resolution through automatic arbiter generation, automatic code generators, simulator, among others. In this sense, the main goal of the proposed Petri net class and associated tools is to support the entire system development flow, from specification to implementation.


The oxidation of sodium bisulfite in the presence of cationic polyelectrolytes or micelles has been studied. The formation of cationic-bisulfite complexes is indicated, and a kinetic analysis suggests the validity of the enzyme kinetics applied to determine the kinetic parameters. Distinct differences in the activity of cationics depend on the configuration of the cationics in solution; micelle-forming cationics are more effective than nonmicellar polycationics, except in the case of poly(diallyldimethylammonium chloride), (PDADM). The oxidation rate is strongly affected by the presence of monomer in the system, especially where nonmicellar polycationics are involved.


The purpose of this study is to examine the intention to enroll reward programs that companies are introduced as a marketing strategy for increase profits. In particular, this study assumes the mobile shopping context that is growing rapid in recent, unlike previous studies to study the offline or online contexts. To develop the research model, we focused on the customers value(cash value, aspirational value, redemption of choice value, relevance value, convenience value), the perceived goal-proximity(PG), the perceived enjoyment(PE), and the intention to enroll. The structural model analysis reveals two points. The first is aspirational value and relevance value are significant impact on PG, relevance value and convenience value are significant impact on PE, and PG and PE are significant impact on intention to enroll. The second is the difference between the high reward experience group and the low reward experience group. Specially, relevance value and convenience value on PG occur the path difference between the two groups. As a result, this study enhances our conceptual understanding of the customer value and suggests more effective solutions to corporates in mobile shopping.


According to the invention a light metal cylinder liner with a surface which facilitates the connection with the surrounding cast material may be produced, whereby the cylinder liner is produced by means of a lost-foam method with a form for production of the cast foam model having a structured surface with height variations of 0.8 to 5 mm, said structuring being for example grooves or longitudinal elevations.


We present herein the first high-power rapidly wavelength-swept laser in the 780-nm band. A commercial diode laser was modified to increase its sweep frequency up to 30 kHz thus allowing its use for real-time biomedical imaging. The tuning range of the laser starts at 761 nm and goes up to 798 nm. The maximum output power of the laser after coupling it into a single-mode fiber is 54 mW and its coherence length is 11 mm. The potential of this laser for biomedical imaging was demonstrated in a spectrally encoded setup.


This letter presents a broadband self-driving radio frequency-to-direct current (RF-dc) rectifier design realized on the CG2H40010F Cree's GaN device. First, the transistor modeling parameters for the reverse-biased <inline-formula> <tex-math notation="LaTeX">$I$ </tex-math></inline-formula>–<inline-formula> <tex-math notation="LaTeX">$V$ </tex-math></inline-formula> characteristics have been obtained to achieve the high-frequency rectification at negative drain biasing. Besides, an enhanced self-synchronization is achieved across the operating bandwidth through an additional microstrip open-stub line at the gate input matching network. Thus, an additional line maintains a fixed 180° phase offset between drain and gate voltages. Finally, the rectifier efficiency of >60% has been measured from 2.65 to 2.95 GHz for 10-W RF input power. The designed rectifier has been outperformed the recent designs in terms of operational bandwidth (300 MHz) and rectification efficiency.


The stability of a diffusion flame anchored at impinged point at right angle between air and fuel gas was studied. The stability of the flame may be affected by the flow and mixing field between fuel and oxidizer in the vicinity of the burner port where the flame attaches. To make such circumstances clear, velocity and concentration profiles were studied experimentally using a cold model. Results were as follows : (1) In the vicinity of the burner port, a pair of recirculation zones could be found out. And in the circulation zone, velocity was so small that the zone itself was not so effective as to control the profile outside of the zone. (2) In the outer region of this zone, the dimensionless velocity and concentration profile could be obtained.


The structure of musical scales has been proposed to reflect universal acoustic principles based on simple integer ratios. However, some studying tuning in small samples of non-Western cultures have argued that such ratios are not universal but specific to Western music. To address this debate, we applied an algorithm that could automatically analyze and cross-culturally compare scale tunings to a global sample of 50 music recordings, including both instrumental and vocal pieces. Although we found great cross-cultural diversity in most scale degrees, these preliminary results also suggest a strong tendency to include the simplest possible integer ratio within the octave (perfect fifth, 3:2 ratio, ~700 cents) in both Western and non-Western cultures. This suggests that cultural diversity in musical scales is not without limit, but is constrained by universal psycho-acoustic principles that may shed light on the evolution of human music.


Neutron spin-echo spectroscopy (NSE) offers unprecedented opportunities in the investigation of diffusion in crystalline systems due to its outstanding energy resolution. NSE not only enables measurements at lower diffusivities than the established techniques of neutron spectroscopy, but it also gives a very immediate access to the different time scales involved in the diffusion process. This is demonstrated in detail on the example of the binary alloy NiGa where the Ni atoms hop between regular sites on the Ni sublattice and anti-sites on the Ga sublattice. Experiments on two different NSE instruments are compared to measurements using neutron backscattering spectroscopy. The potential of NSE for the investigation of jump diffusion and experimental requirements are discussed.


The missile launcher of the carrier-based fighter, which directly affects the completion of a launching mission, encounters crucial environmental adaptability problems like high temperature brought by the rocket flame and the marine climates, thus requires higher reliability while being compared to most other parts of the fighter. In this paper, the failure mode and mechanism of carrier-based fighter missile launcher caused by humidity, fungus and salt-fog were analyzed first, especially the corrosion problems. Three-proofing structural design and protection technologies were discussed as followed. Optimum material selection principles as well as some new detection measures were put forward at last.


Introduction: The presence of neutropenia or neutrophilia is observed in the evaluation of the neonate with suspected sepsis; however, its incidence has not been estimated in our population in the absence of systemic infection. Mate- rial and methods: A cohort of newborns at term, with low perinatal risk, were followed from birth to two months of age, leukocyte count, neutrophils (NT), and total lymphocyte (TL) were evaluated; the frequency of neutropenia at these ages was determined. Results: We included 110 infants; the mean values of the total leukocyte count were 18,950/ μL (CI 95% 10,255-29,170); 11,250/μL (6,030-17,045) and 9,750/μL (6,055-17,900); total lymphocytes, 7,442/μL (4,736 to 11,326), 8,198/μL (2,625-12,559) and 7,478/μL (4,276- 12,782); total neutrophil count, 7,818/μL (2,853 to 13,809), 2,112 (927-7,021) and 1,944 (737-3,618) at birth, one and two months, respectively. Signifi cant neutropenia ( 9,500/L) was present in 35.5% of infants at birth, but in none in the fi rst and second months of age. Conclusions: The presence of neutropenia or neutrophilia is a physiological change in low-risk infants. This fact must be considered when evaluating sepsis at this age.


Most medicines depend on a good understanding by the patient of how to take or use the medicine safely and effectively. Such actions relate strongly to people's health literacy, defined by Kickbusch and Maag as 'The ability to make sound health decisions in the context of everyday life – at home, in the community, at the workplace, the health care system, the market place and the political arena'. They go on to say that it is 'a critical empowerment strategy to increase people's control over their health and ability to seek out information and their ability to take responsibility'. The landmark US Institute of Medicine report, Health Literacy: a Prescription to End Confusion, reported that low health literacy negatively affects the treatment outcome and safety of care delivery. The people concerned are more likely to be admitted to hospital, and they may stay longer and be less likely to take their medicines and/or make errors with those medicines. So, health literacy covers a very wide range of activities, and people's ability to make good decisions about medicines, and use them safely and effectively, form an important part. Such 'medication literacy' has yet to be defined, but it could be argued that it is a person's ability to make decisions about medicines that are right for them, allowing the medicines' safe and effective use. Low health literacy is a factor that underpins the wider issue of health inequality, as getting the best out of a health system is complex and arguably requires high levels of health literacy. According to the UK Department of Health, over half of England's adult population have literacy skills below Level 2. It is sobering to note that this is the level needed to discuss a condition interactively with a doctor or specialist.


Graph Neural Networks(GNNs) learn node representations of graphs through topological structure neighborhood propagation and aggregation. It has achieved great success in graph learning tasks and is widely used in node classification tasks. However, graphs in the real world are usually sparse and noisy, and noise can also affect surrounding nodes through topological structure, which negatively affects the performance of GNNs. In this paper, we propose a new framework to deal with these problems. Specifically, first, we design an edge generator to densify the sparse graph using node similarity and reduce the weight of noisy edges. Then, adaptive label propagator generates pseudo-labels based on topological structure, and the dynamic and adaptive weighting strategy of the adaptive label propagator can overcome the shortcomings of GNNs on noisy labels. Finally, we use the topology information and node information of the obtained new graph for final classification and pseudo-label reweighting through GNNs. Experimental results on public datasets indicate the superiority of our method over existing baselines, demonstrating the robustness of our method to sparse and noisy graphs.


Measuring accurately Sea Surface temperature is important for many marine applications and monitoring the global climate system. Many instruments are used for the measuring the SST. The SST delivered from satellite have the advantages that are a broad scope and consistent detection. But SST products show the different value because of different of retrieval algorithm and sensor. To reduce the uncertain, SST data ensemble is carried out using the Bayesian model averaging(BMA). BMA is method of the weighted average using the posterior probability distribution. And the means and variances of the posterior probabilities are estimated using Expectation-Maximization(EM) algorithm. The estimated mean of the posterior probability is used as the weight for the weighted average. SST data of Aqua/MODIS, Terra/MODIS and NOAA/AVHRR was used as ensemble member. SST data Envisat/AATSR was used as reference data for calculating the posterior probability and validation data. To make the monthly ensemble SST, their provided monthly SST data was used. one-leave-out-cross validation that is one of the statistical validation method is used for validating the ensemble SST. The 12 cases, except for the data of one month per the case, was made and excepted month was used validation period. And we compared with the ensemble mean and median. As the result, ensemble BMA showed the lowest RMSE.


1Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway; 2Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; 3Department of Neurology, University Hospital of North Norway, Tromsø, Norway; 4Clinic for Heart Disease, St. Olav's University Hospital, Trondheim, Norway; 5Department of Cardiology, University Hospital of North Norway, Tromsø, Norway Purpose: To assess whether acute myocardial infarction (MI) diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for a population-based, epidemiological study. Patients and Methods: Using the Tromsø Study Cardiovascular Disease Register for 2013–2014 as gold standard, we calculated correctness (defined as positive predictive value (PPV)) and completeness (defined as sensitivity) of MI cases in the Norwegian Myocardial Infarction Register and the Norwegian Patient Register separately and in combination. We calculated the sensitivity and PPV with 95% confidence intervals using the Clopper-Pearson Exact test. Results: We identified 153 MI cases in the gold standard. In the Norwegian Myocardial Infarction Register, we found a PPV of 97.1% (95% confidence interval (CI) 92.8–99.2) and a sensitivity of 88.2% (95% CI 82.0–92.9). In the Norwegian Patient Register, the PPV was 96.3% (95% CI 91.6–98.8) and the sensitivity was 85.6% (95% CI 79.0–90.8). The combined dataset of the Norwegian Myocardial Infarction Register and the Norwegian Patient Register had a PPV of 96.6% (95% CI 92.1–98.9) and a sensitivity of 91.5% (95% CI 85.9– 95.4). Conclusion: MI diagnoses in both the Norwegian Myocardial Infarction Register and the Norwegian Patient Register were highly correct and complete, and each of the registers could be considered as endpoint sources for the Tromsø Study. A combination of the two national registers seemed, however, to represent the most comprehensive data source overall. The benefits of using data from national registers as endpoints in epidemiological studies include faster, less resource-intensive access to nationwide data and considerably lower loss to follow-up, compared to manual data collection in a limited geographical area.


During my training stay at the Wellcome Trust Centre for Neuroimaging at the University College London, I had the unique opportunity to learn about dynamic causal modelling (DCM), a biophysical modelling approach, from leading experts in the eld. Although it is most commonly applied to fMRI data, its utilization ranges from invasive to non-invasive measurements. As broad as the data modalities are that DCM is compatible with, as great is the number of research elds, in which DCM is applied. Especially cognitive neuroscience and computational psychiatry have taken advantage of the technique. Since its key paper release in 2003 more than 130 papers have been published on the topic. In my project I used DCM to study the relation between fast electric signals and slow, laminaspeci c hemodynamic signals. The aim was to establish the lamina-speci city of neuronal dynamics in early visual cortex. In this setting, lamina-speci c refers to the cortical layers of origin of the di erent signals generated by neuronal activity. To achieve this I used concurrently measured EEG and fMRI data from a cued visual attention task([8]). DCM enabled me to infer on spectral responses at di erent cortical depths, which in turn I then used as regressor in a general linear model for the fMRI data. The concurrent recording of EEG and fMRI data gave me the opportunity to compare the modalities on a trial-by-trial basis. The goal of DCM is to explain the generation of experimentally observed data features by dynamics of a network containing hidden states (i.e. not directly observable). In particular, if DCM is applied to EEG data, these networks are based on neural mass models (for example the canonical microcircuit in Figure 1) of cortical columns. This makes it possible to directly test predictions of theoretical models against the data and estimate physiologically meaningful model parameters. The temporal variation in every cell population of the neural mass model is de ned by two ordinary di erential equations, describing the change in voltage and current. The equations describe the transformation of the presynaptic spikes to postsynaptic output by a convolution of a synaptic alpha kernel with incoming spikes. The ring rate and hence output of single populations is approximated by a sigmoidal function. The output of the cortical column is then a weighted sum of the output of the three excitatory cell populations but is dominated by (deep and super cial) pyramidal cells. Based on time-frequency analysis of a virtual electrode time series in early visual cortex, we assumed similar statistical feature and frequency content for the sustained gamma component, i.e. about 500ms after stimulus onset until the end of the stimulation period. This allowed us to summarize the spectral content into steady state responses that we used as features in the DCM ([6]). Using Bayesian Model Inversion we obtained the parameters of the network, such as connection strengths and synaptic time constants. This enabled us to estimate the spectral responses of di erent subpopulations (Figure 1), which in turn can be linked to di erent cortical


I approached this task from the perspective of a senior National Health Service (NHS) manager with significant involvement in policy formulation at national level and a practising Chief Executive with a long-term involvement in the NHS Research and Development programme. I accept that health care managers are low users of research evidence and have little tradition of using the library, in whatever form, to find the answer. On the other hand, researchers have a different perception of what constitutes good or useful research and measure their success in a way which does not encourage connectivity with management or policy making. The longstanding arguments between timeliness and thoroughness have moved on little. Syntheses of existing knowledge by those with skills in translating into the language of the reader offers a real opportunity to increase the utilization of research by tackling the timeliness and usability issues. The process of reviewing these papers at an interim stage has clearly improved their final product.


Based on the theory of labor and salary,potential forms and distribution situation as well as the forms of materialized labor,the shortcomings in the distribution system of universities in China were analyzed in the paper.The idea of distribution system was put forward as followings:the amount of salary should be based on the post,and the performance efficency should be taken into account,so the distribution system can guarantee those who are diligent and efficient can get better payment. By reforming the distribution system, the institutes of higher education can possess top talents, get excellent achievements and reward the excellent talents with higher wages to arouse the teaching staff's enthusiasm, initiative and creativity.


The use of a stroke emergency mobile unit speeds thrombolysis and thus improves short-term outcomes, with no risk to patients' safety.


This article aims at reflecting briefly on the debates between opinion and information as posited in the weeklies Accion, Marcha and Ercilla during the 1930s and 1940s. Within a clearly political dimension, the three weeklies promoted significant intellectual, political and cultural discussion among authors who defended the inclusion of different interpretations, but disagreed on how the news or texts should be presented to readers. Information or commentary: how to establish a dialogue with the public? To lead opinion or to appear as neutral in the public life debate?


The paper detailedly analyzed problems of how to determine lag time of data between two sensors,effect of sensor error,accuracy rate of alarm in application of alarming method for abnormal data of coal mine gas based on three kinds of correlation models of difference between the maximum and the minimum,the minimum and correlation coefficient,and proposed that data curve comparison method should be used instead of distance anemometer algorithm to determine the lag time,meanwhile,found phenomenon that movement speed of gas air mass in roadway is lower than wind speed and gave preliminary explanation for the phenomenon.It proposed a method to use mathematical statistics method to eliminate effect of sensor error.Combined with field data,verification was conducted on accuracy rate of the three kinds of correlation models,and the result shows that the alarming method can be effectively applied in practice.


A 6-year-old, male intact Chihuahua was presented to the Veterinary Teaching Hospital of the University of Bern after experiencing a single generalized seizure. The dog was hypothermic (rectal temperature, 36.1°C), obtunded and had a non-ambulatory tetraparesis. Postural reactions were reduced in all 4 limbs and a right-sided head tilt, a severely reduced menace response, delayed direct and consensual pupillary light reflexes, and bilaterally absent nasal sensation and corneal reflexes were present. Other cranial nerve reflexes and segmental spinal reflexes were considered normal, and no pain response was elicited on spinal palpation or by passive movement of the head and neck. The clinical findings were consistent with multifocal intracranial disease with involvement of the forebrain and brainstem. There was regenerative anemia (hematocrit 0.33 L/L; reference range, 0.39–0.57 L/L, reticulocytes 209.6 9 10/ L; reference range, 10.9–111.0 9 10/L), a neutrophilic left shift (band neutrophils 0.55 9 10/L; reference range, 0.0–0.3 9 10/L) without neutrophilia (8.31 9 10/L; reference range, 3.0–11.5 9 10/L) and lymphopenia (0.6 9 10/L; reference range, 1.0–4.8 9 10/L). Hypokalemia (3.71 mmol/L; reference range, 4.22–5.43 mmol/L), hypocalcemia (2.15 mmol/L; reference range, 2.42– 2.85 mmol/L), hypocholesterolemia (2.89 mmol/L; reference range, 3.47–10.03 mmol/L), hypoproteinemia (48.4 g/L; reference range, 56.0–73.0 g/L), hypoalbuminemia (24.1 g/L; reference range, 30.0–40.5 g/L), a low serum creatinine concentration (29 lmol/L; reference range, 52–117 lmol/L), hyperbilirubinemia (21.3 lmol/L; reference range, 0.5–3.9 lmol/L), and increased activity of alanine aminotransferase (661 IU/L; reference range, 26–126 IU/L), alkaline phosphatase (251 IU/L; reference range, 9–132 IU/L), aspartate aminotransferase (343 IU/ L; reference range, 22–76 IU/L), creatine kinase (781 IU/ L; reference range, 64–400 IU/L), gamma-glutamyl transferase (19 IU/L; reference range, 1–7 IU/L), and glutamate dehydrogenase (45 IU/L; reference range, 2–10 IU/ L) were present. Abnormalities were not noted on urinalysis and oscillometric blood pressure measurements were within normal limits. Right and left lateral thoracic radiographs revealed mild generalized cardiomegaly without evidence of congestive heart failure, minimal pleural effusion, and reduced abdominal detail. Abdominal ultrasound revealed mild anechoic fluid with signs of peritonitis and steatitis of the abdominal fat, hepatomegaly and mild bilateral pyelectasis. Abdominocentesis revealed a clear fluid with low total protein concentration (12 g/L), consistent with transudate. Magnetic resonance imaging (MRI) of the brain revealed multifocal intra-axial, sharply delineated lesions, mainly affecting the gray matter in the cerebellar vermis, right brainstem, left thalamus, right caudate nucleus, and dorsolaterally in the area of the right parietal and occipital lobes without mass effect. These lesions were hyperintense on T2-weighted (T2W) and fluid attenuation recovery (FLAIR) sequences, and hypointense on T1-weighted (T1W) sequences with no contrast enhancement after intravenous administration of 0.15 mmol/kg gadodiamide and no evidence of hemorrhage on T2*-weighted (T2*W) gradient echo sequences (Figs 1A, 2A). The lesions were hyperintense on diffusion weighted images (DWI), and hypointense on the apparent diffusion coefficient (ADC) map, indicating restriction of diffusion (Figs 1B, 2B). No abnormality of the basilar artery was observed on conventional T1W and T2W spin echo, FLAIR, T2*W, and DWI MRI sequences, however, MR angiography was not performed. MRI findings were compatible with multifocal, acute, ischemic infarction. Cerebrospinal fluid, collected from the cerebellomedullary cistern, contained 27 white blood cells per From the Division of Neurological Sciences, (Salger, Vandevelde, Henke); the Division of Clinical Neurology, (Salger, Vandevelde, Henke); the Department of Clinical Veterinary Medicine, (Salger, Stahl, Vandevelde, Henke); the Division of Clinical Radiology, (Stahl); and the Department of Veterinary Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (Piersigilli). Corresponding author: F. Salger, Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland; e-mail: firstname.lastname@example.com. Submitted March 28, 2014; Revised June 9, 2014; Accepted July 30, 2014. Copyright © 2014 by the American College of Veterinary Internal Medicine DOI: 10.1111/jvim.12447 Abbreviations:


Objective:Explore the occurrence of adverse reactions of quinolones and clinical control measures.Method:A total of 27 cases of quinolone ADR reports collected in our hospital in 2009 were analyzed statistically in respect of patients age and sex,route of administration,drug varieties,organs or systems involved and the clinical manifestation.Result:Lesions of skin and its appendages were the most common damages of quinolone ADR.Conclusion:Importance should be attached to the reporting and monitoring of quinolone ADR reports in the clinic and reduce the incidence of adverse reactions.


The fully operational Detector Control System (DCS) for the High Momentum Particle Identification Detector (HMPID), developed in PVSS 2.12.1, is described. As a future development, some details on the implementation of the new DCS version in PVSS II v3.0 are also presented.


The magnetization reversal resulting from the thermal fluctuation is irreversible for overcoming the energy barrier, ant it is called as the thermally assisted tunneling. In this paper the relaxation in magnetizaition reversal resulting from the thermal fluctuation is observed in Pr-Fe-B permanent magnets. The dependence of magnetic moments on the time natural logarithm is same as that on the energy barrier in the thermally assisted tunneling. So the relaxation in magnetization reversal is originated from the macroeffect of magnons which follow Bose distribution law. The critical size in the irreversible magnetization reversal obtained by the fluctuation field is in nanometer scale and closed to the theoretical domain wall size, indicating that the thermal assisted magnetization reversal undergoes the nucleation and de-pinning of domain wall. The increase of coupling volume would reduce the possibility of magnons tunneling in magnetization reversal due to the weakening effect of thermal fluctuation. The variation of fluctuation field with the field verifies the effect of exchange coupling in Pr-Fe-B magnets, and the calculated value of fluctuation field is consistent with the aftereffect of thermal activation. With the increase of temperature the thermal fluctuation energy increases, and though the aftereffect of thermal fluctuation weakens due to the exchange coupling, the ratio of thermal fluctuation aftereffect and coercivity increases in Pr-Fe-B magnets.


Why agencies, and why now? The proliferation of agencies is not accidental; it entails much more than merely rearranging the organisational map of government. There is a logic to the popularity of agencies that sheds light on the current state of democratic governance. Every government that embraces agencies does so for its own reasons, but as diverse as they may appear to be, all the reasons are the same. Some governments set up agencies to empower managers, others to emphasise service delivery, still others to evade personnel controls or other administrative constraints. As different as these motives may be, all attest to the belief that the inherited department-centred model no longer satisfies the organisational needs of government.


The problems of analysis of improving the safety systems for ships reactor facilities, which are designed to prevent the escape of coolant outside circuit, protective cover and the environment are considered. Developed logical structural relationship of possible development of the accident and the subsequent introduction of safety systems provided by the project to ensure minimal impact from the accident. On all floating objects a few levels are executed of the echeloned defence, preventing the exit of coolant-moderator in an environment. Every subsequent level is entered in case of the not sufficient working off previous. Thus an exit of active isotopes in an environment is an improbable event. It is shown that the evolution of security systems comes from the active to the passive principle of operation, which increases the reliability of their working in emergency situations. New security systems are introduced on ships with nuclear power installations in order to avoid accidents that have already occurred at operating nuclear ships or at increasing international and Russian requirements for the safety of nuclear facilities.


This article focuses on the development of software engineering standards in the Institute of Electrial and Electronics Engineers (IEEE). (Portions of this article are reprinted, with permission, from Software Engineering Standards: A User's Road Map, by James W. Moore, IEEE Computer Society Press, copyright 1997 IEEE). It briefly describes the overall IEEE, its Computer Society, and its Standards Association. It then goes on to describe the Software Engineering Standards Committee, where software engineering standards are developed.

The Institute of Electrical and Electronics Engineers (IEEE) is the world's largest technical professional society, with membership numbering more than 350,000 individuals in 150 countries. The organization claims to produce 30% of the world's published literature in electrical engineering, computing, and control technology. It conducts more than 300 major conferences per year and maintains more than 800 standards, with another 700 under development. The IEEE is organized into 36 Technical Societies. Software engineering is of interest to several societies, e.g., the Communications Society and the Power Engineering Society, but its primary focus is within the Computer Society.

Keywords:

computer society;
standards association;
standards committee


The invention discloses a low-silver lead-free solder paste soldering flux with high ductility, the main ingredients of the soldering flux comprise tin, silver, copper, scandium, tantalum and ruthenium, wherein silver accounts for 0.3%, copper accounts for 0.7%, scandium accounts for 1-5%, tantalum accounts for 2-5%, and ruthenium accounts for 2-5%. A rare earth metal adding method is adopted, so the cracking phenomenon is obviously improved, the product stability is increased, and moreover, the corrosion resistance and thermostable performance of the soldering flux are obviously improved.


Thanks to the detector technology development based on high Z materials (GaAs, CdTe, CZT, etc.), the hybrid pixel detectors with direct photon-to-charge conversion become more and more popular, even in medical applications. Single photon counting systems aim at good position resolution, so making a pixel size smaller is a general tendency in such systems. However, for the detectors with pixel pitch of about 100 μm charge division effect becomes visible and it affects up to 20–30% of all interactions, depending on detector thickness and bias voltage. For the smaller pixel size this effect is even more pronounced. In this article we propose a new algorithm for charge sharing compensation—the Multithreshold Pattern Recognition algorithm. The algorithm was implemented in a readout circuit of pixel architecture with four energy thresholds, designed for operation with wide energy-range X-ray radiation. The simulation results and implementation details are presented in this paper.


A study was conducted to compare the quality characteristics of non-melting flesh (NMF) peach genotypes intended for fresh market use with the standard melting flesh (MF) peach genotypes, and to determine the effect of storage at 8 °C on the physical and chemical composition of the respective fruit types. In general, mesocarp firmness, skin L (lightness) and hue (red and orange components) decreased significantly with time in storage. This decrease was much more dramatic in MF genotypes than in their NMF counterparts. Water-soluble uronic acids increased significantly in both flesh types. Total soluble solids and total uronic acid content showed little or no change depending upon the genotype. NMF fruits had significantly higher hue and L values, firmness, soluble solids and total carotenes and xanthophylls than their MF counterparts. Water-soluble pectin content was significantly higher in MF genotypes.


Bismuth borophosphate glasses containing different doping cerium oxide have been synthesized at 1200 °C by melt-quenching technique. The doping concentration of the Ce3+ was varied from 0.05 mol% to 2.0 mol%. The glass samples were characterized through optical absorption and luminescence spectral measurements. UV-visible and near infrared absorption spectra of glass samples were not observed nevertheless the absorption edge was shift to the longer wavelength. The photoluminescence and radioluminescence spectra show emission bands around 367 nm under 317 nm excitation wavelength. Also, the highest emission intensity was found at 0.5 mol% CeF3 dopant for both of photoluminescence and radioluminescence.


For a foreign observer who has been trained in German and French psychopathology, British psychiatry is very attractive at first glance for a number of reasons. Its eclectic and principally non-theoretical approach (Cooper, 1975), characterized by an open acceptance of foreign concepts and by the tendency to question traditional structures and hypotheses and to test them by means of statistical methods, appears most impressive. The substantial contribution British authors have made toward the development of structured tools in psychopathology, like for instance the Present State Examination or the Hamilton Rating Scale in order to facilitate such a statistical evaluation, which reflects clearly the inheritance of Sir Francis Galton, is also a cause of sincere admiration. The European observer realizes furthermore that the British approach is rooted mainly in continental, especially in German, clinical psychiatry, and is not as heavily influenced by psychodynamic theories as, for instance, the American schools were, at least until recently. This provides him with a comfortable feeling of familiarity and he is not inclined to question certain British tenets until his involvement progresses and he becomes aware of the comparative lack of attention paid by British schools to some of the fundamentals of continental psychopathology.


Objective To analyse the correlation between serum high-sensitivity C-reactive protein(hs-CRP) and insulin resistance in type II diabetes,and discuss whether elevated serum hs-CRP level is associated with development of type II diabetes.Methods In 122 patients with type II diabetes,serum hs-CRP,FPG,FINS,TG,TC,HDL-C,LDL-C,UA,HbA_1c,blood pressure and BMI were measured.Homeostasis model assessment(HOMA) and improved insulin sensitivity index(ISI) were applied to assess the status of insulin resistance(IR).Results It was found that SBP,DBP,BMI,TG were significantly higher in elevated hs-CRP group than in normal hs-CRP group(P0.01).Serum hs-CRP was positive correlated with DBP,BMI,FPG,FINS,TG,UA,IR in type II diabetes(P0.05),but was negative correlated with HDL-C and ISI(P0.05). Conclusions There was positive correlation between Serum hs-CRP and insulin resistance in type II diabetes.Elevated Serum hs-CRP predicted the development of type II diabetes.


Waiting for the train at a small station of the circumvesuviana train line in the outskirts of a city, waiting in a courtyard transformed by time in new urban architectures, waiting in the large buildings of the council housing, waiting at the railway station in the city center. Places that cross the metropolitan spaces, characterizing them with their forms and hosting lives in transit which adapt themselves to the places where they lived. Ponticelli, the eastern outskirts of Naples, is a difficult neighborhood because of the stagnant economy, rich in history and traditions is tight between the status of outskirts and a strong will to emerge. In-attese is a photographic work carried out in parallel with an ethnographic study for about eighteen months. The photographs here presented show symptomatic places of the urban and social transformations that have taken place from the post-war period to the present day and portray forms of cultural persistence that create social cohesion in an existential coexistence that characterizes the face of the neighborhood.


Review of Campus Wars: The Peace Movement at American State Universities in the Vietnam Era by Kenneth J. Heineman.This article can also be found at the Monthly Review website, where most recent articles are published in full.Click here to purchase a PDF version of this article at the Monthly Review website.


Emerging from the lingering effects of two decades of quick fix and piecemeal strategies for success, American companies are searching for strategies that will prepare them to take their place in the new corporate order of the 21st century. From the authors of the bestseller The Genius of Sitting Bull, comes Forging the Heroic Organization, which utilizes a revolutionary business-building strategy that is both cutting-edge and battle-tested over centuries. It is based on the sacred Sioux concept of Cangleska Wacan, a hoop or medicine circle that embodied the interrelationship of everything under the sun - humans, their organizations and their environment into one continuous process of growth and development. In Emmett Murphy's ingenious adaptation of this concept, leaders are shown a proven process of collaborative work redesign and continuous improvement that can be applied to every stakeholder who depends on the success of the organization. These stakeholders include front-line managers, employees, suppliers, customers, shareholders and the Board, the community, the environment, government, international partners, and the global competition. Murphy shows how businesses can harness the energy of their stakeholders to respond with flexibility and speed to opportunities for growth, new product development, and all the expected and unexpected crises that occur in corporate life, from the challenge of restructuring and reengineering to sales and market share decline, from government regulation to international competition. The time has come for businesses to rethink and address the crucial interrelationships upon which their success - and their very livelihood - depends. Emmett Murphy'sForging the Heroic Organization charts the course all companies can follow in the quest for real growth and strength that stands the test of time.


Online non-intrusive load monitoring algorithms have captivated academia and industries as parsimonious solutions for household energy efficiency monitoring as well as a safety control, anomaly detection, and demand-side management. However, the computational energy cost for executing such algorithms should not overcome the promised energy efficiency from the disaggregated appliance specific consumption information feed-backs. Moreover, the energy efficiency of cloud computing systems is also becoming a concern for the environment due to carbon emission. This study analyzes the energy spent to execute NILM algorithms via computation cost estimation and prediction using computing system-level power monitoring and data-driven approaches. A generic framework for an automated algorithm cost monitoring and modeling methodologies is devised for large load scale deployment of Cloud-based Online-NILM algorithms. The efficacy of the proposed approach was examined and validated on two computing system use-cases, i.e., Dedicated Server and Cloud Virtual Server. The prediction models, developed using statistical and machine learning tools, demonstrate the promising applicability of the data-driven approach with a very high prediction accuracy without detailed knowledge of the computing systems and the algorithm.


Early modern composite monarchies functioned by maintaining local rights and traditions and the successful accommodation of noble elites in the army, diplomatic corps, and regional governments. Scholars commonly focus on the integration of nobles from the core lands in order to implement a faithful civil service and reliable institutions for government. Yet noble families from peripheries or border regions have been disregarded either as supporters or as opponents of royal power. This article explores the differing strategies of the Carrettos from Imperial Italy and the Arenbergs from the Southern Netherlands, two noble families from the border regions of the Habsburg realms and how they responded to integrative measures offered by the Spanish and Austrian Habsburgs. It analyses four important aspects of noble family strategies. First, the article examines how vassalage, loyalty, and sovereignty created important bonds between noble families in the western border regions of the Holy Roman Empire and the emperor or sovereign. Second, it establishes how families became members of competitive Habsburg court societies via court honours, titles, and interregional marriage alliances. Third, the article looks at how these families supported the early modern state with successful performances of state service and how they utilized the vast career possibilities of composite monarchies. Fourth and finally, it analyses how the failed integration of noble elites from border regions resulted in governmental crisis and uprisings. This article demonstrates how nobles in the border regions could be integral to state power.


Constituents will get the chance to chat with their local MP at his regular 'shoppers surgery' to be held at the Marks and Spencer (M&S) store at ...


HMG-CoA reductase is the rate-limiting enzyme of cholesterol biosynthesis. As intracellular levels of cholesterol should be regulated elaborately in response to external stimuli and internal needs, the expression of the HMG-CoA reductase gene is regulated intricately at several different levels from transcription to post-translational modification. In this study, we investigated the regulatory mechanism of HMG-CoA reductase gene expression at the post-transcriptional/pre-translational levels in a baby hamster kidney cell line, C100. When 25-hydroxycholesterol was added to cells cultured in medium containing 5% delipidized fetal bovine serum and 25 μM lovastatin, the levels of HMGCoA reductase mRNA decreased rapidly, which seemed to be due to the increased degradation of reductase mRNA. These suppressive effects of 25-hydroxycholesterol on HMG-CoA reductase mRNA levels were blocked by a translation inhibitor, cycloheximide. Similarly, actinomycin D and 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole, transcription inhibitors, blocked the 25-hydroxycholesterol-mediated degradation of HMG-CoA reductase mRNA. These results indicate that new protein/RNA synthesis is required for the degradation of HMG-CoA reductase mRNA. In addition, data from the transfection experiments shows that cis-acting determinants, regulating the stability of reductase mRNA, were scattered in the sequence corresponding to 1766-4313 based on the sequence of Syrian hamster HMG-CoA reductase cDNA. Our data suggests that sterol-mediated destabilization of reductase mRNA might be one of the important regulatory mechanisms of HMG-CoA reductase gene expression.


The warm good-bye gift "Tuan-Time" for graduates in Xiamen University was described in details, which online and offline activities are both involved.


Purpose: The aim was to identify and describe nursing actions performed by nursing staff in which patients with wet age-related macular degeneration (AMD) experience good nursing care.Method: An ex ...


While the influence of culture on negotiation styles has seen increased coverage recently, research on subcultural differences has been scarce. Especially, a rare example of subcultural effects is the study of negotiation styles of Chinese. This study will discuss the effect of subcultural differences on negotiation styles in Chinese society. A few keycities in China such as Beijing, Shanghai, Guangdong (Canton), Heilongjiang, Jilin, Liaoning, Sichuan, and Zhejiang will be described for the characteristics of the inhabitants in these cities. In addition, Hong Kong and Taiwan have developed their different subcultures from Mainland China.


Background: Poor soil fertility management in Ghana has necessitated the need to investigate the appropriate source of nitrogen which enhances nitrogen use efficiency and improves maize productivity under rainfed condition. Methods: The experiment consisted of five treatments; control (no fertilizer), NPK 15-15-15 (90 kg N ha-1), urea (90 kg N ha-1), poultry manure (4.2 tons ha-1) and combination of NPK 15-15-15 and poultry manure (½NPK 15-15-15 + ½ poultry manure). Randomized complete block design was the experimental design used for the experiment with three replications. Result: The greatest grain yield (5,551 kg ha-1) and biomass yield (14,296 kg ha-1) for the major rainy season were recorded by the combined application of NPK 15-15-15 and Poultry manure treatment, while the highest grain yield (3,507 kg ha-1) and biomass yield (7,976 kg ha-1) was recorded by NPK 15-15-15 treatment during the minor rainy season.


We present the techniques and early results of our program to measure the luminosity function for White Dwarfs in the SuperCOSMOS Sky Survey. Our survey covers over three quarters of the sky to a mean depth of I~19.2, and finds ~9,500 Galactic disk WD candidates on applying a conservative lower tangential velocity cut of 30kms^-1. Novel techniques introduced in this survey include allowing the lower proper motion limit to vary according to apparent magnitude, fully exploiting the accuracy of proper motion measurements to increase the sample size. Our luminosity function shows good agreement with that measured in similar works. We find a pronounced drop in the local number density of WDs at a M_bol~15.75, and an inflexion in the luminosity function at M_bol~12.


Article info: Received: 05 Jan 2021 First Revision: 23 Jan 2021 Accepted: 25 Feb 2021 Published: 01 Apr 2021 2018 The Authors. This is an open access article under the CC-By-NC license.


The authors present an interesting analysis of delusions which should be kept in mind when considering such symptoms in the patient.


The calculation of the Loss of Load Probability (LOLP) is an important element in generation planning studies. LOLP is calculated either independently to evaluate the risk of a certain generation system or in conjunction with several planning application programs such as, generator maintenance scheduling, probabilistic production costing, hydrothermal scheduling, generation expansion, etc. Exact calculation of the LOLP requires the calculation of the Capacity Outage Probability Table (COPT). This table takes into consideration the capacity rating the the forced outage rates of the generating units of the system and it provides the probability values associated with various amounts of system capacity on outage. The capacity outage table is calculated by utilizing the well known recursive convolution formula. Usually the table is simplified by rounding the capacity outage table to selected discrete capacity levels. The size of the round off increment depends on the desired accuracy. The classic approach is time consuming and requires a considerable amount of computer memory. In order to reduce the computational time and computer storage several methods have been proposed, in which the capacity outage probabilities are approximated with analytic continuous probability distributions. Most of these methods utilize the Central Limit Theorem, Fourier techniques and the Gram Charlier's expansion. Closely related to the LOLP is the maintenance scheduling problem. Preventive maintenance is required for all generating units in order to reduce the probability of capacity shortage and improve the overall reliability of the power system.


The use of Cornwall automatic pipettes (Becton, Dickinson and Co., Rutherford, N.J.) for the planting of replicate cell suspensions into multiple culture vessels is a routine procedure in some tissue-culture laboratories. This instrument withdraws samples from the bottom of an Erlenmeyer flask in which the cell suspension is continuously stirred by a Teflon-coated magnetic bar. The same apparatus is also valuable in the replacement of media in monolayer cultures. One disadvantage of this pipette is that the design of the apparatus requires the introduction of the aspirating portion, a latex tubing terminating in a hollow metal sinker into the flask. Not only is the exterior of the tubing easily contaminated during transfer to the flask, but the sinker may periodically collide with the Tefloncoated magnetic bar rotating in the bottom of the flask. In addition, the passage of the latex tubing out of the neck of the flask requires a loose-fitting closure to eliminate kinking of the tube. This closure, sometimes composed of cheesecloth, cotton, or aluminum foil, is also vulnerable to airborne contamination. Because of the difficulties listed above, a modification to the apparatus is proposed which minimizes the problems. These modifications are illustrated in Fig. 1. An Erlenmeyer flask (300 to 1,000 ml) was fitted with a serum bottle orifice with attached rubber cap and clinched-on metal skirt. The metal sinker of the Cornwall apparatus is replaced by a male Luer-Lok hose end (B-D, Co.; # H/468L). For the preparation of replicate cultures, the surface of the rubber cap is sterilized with 70% ethyl alcohol and flame and punctured with a no. 18 gauge disposable needle which has been attached to the Luer-Lok on the end of the latex tubing. The magnetic stirring bar and the cell suspension are then added to the flask by removing the screw cap. With media alone, the apparatus is convenient for routine feeding of cultures. An additional advantage is that media for several periodic feedings may be stored in the flask, eliminating the necessity of transfer. It is recommended that a single rubber cap be punctured no more than three times, since some leakage occurs with repeated injections. The cap and metal skirt should be removed for thorough cleaning and a new assembly replaced prior to


Current antiepileptic drugs (AEDs) have several shortcomings. For example, they fail to control seizures in 30% of patients. Hence, there is a need to identify new AEDs. Drug repurposing is the discovery of new indications for approved drugs. This drug "recycling" offers the potential of significant savings in the time and cost of drug development. Many drugs licensed for other indications exhibit antiepileptic efficacy in animal models. Our aim was to create a database of "prescribable" drugs, approved for other conditions, with published evidence of efficacy in animal models of epilepsy, and to collate data that would assist in choosing the most promising candidates for drug repurposing.


The analysis of the aromatic region of 1H and 13C NMR spectra of cyclolinopeptide A (cyclic nonapeptide with the sequence c—(Pro— Pro— Phe—Phe—Leu— Ile— Ile— Leu— Val— ), (CLA)) shows that Phe-3 and Phe-4 aromatic rings are oriented nearly perpendicularly to each other, forming edge-to-face pair. It signifies the strong limitation of the free rotation of aromatic residues, probably because of the steric hindrance exerted by proximal aliphatic side chains of CLA.


Waste glass (WG) can be used as fine aggregate and powder in concrete mixtures, preventing pollution induced by this non‐biodegradable material. The properties of WG‐included concrete should be examined before its practical use. Compressive strength (CS) is one of the most crucial characteristics of concrete, and the measurement of which needs time‐consuming and expensive experiments. The use of machine learning (ML) methods for modeling the CS of concrete can help achieve more reliable and precise models. In this study, a comprehensive database of WG‐included concrete was collected from the literature. Next, four ML methods, including support vector regression (SVR), least‐square support vector regression (LSSVR), adaptive neuro‐fuzzy inference system (ANFIS), and multilayer perceptron neural network (MLP) were served in the CS modeling. A recently proposed metaheuristic method, called marine predators algorithm (MPA), was proposed to optimize the control parameters of the ML models to guarantee generalized accuracy. Results indicate that the hybrid LSSVR‐MPA model outperforms the other developed ML models comparing the error metrics with an RMSE = 2.447 MPa and R2 = 0.983. The sensitivity analysis reveals that replacing the cement with WG powder decreases the CS, whereas serving the WG as the replacement for natural fine aggregate improves the CS.


The influences of microstructure, connectivity, and disorder on the critical current density, Jc, are discussed to clarify the different mechanisms of Jc(H) in different magnetic field ranges for in situ and combined in situ/ex situ MgB2∕Fe wires with nano SiC and malic acid codoping. Sintering temperature plays a very important role in the electromagnetic properties at different temperatures and under various magnetic fields. Connectivity, upper critical field, Hc2, and irreversibility field, Hirr, are studied to demonstrate the mechanism of Jc dependence on magnetic field. The combined in situ/ex situ process is proved to be a promising technique for fabrication of practical MgB2 wires.


Digital information and communication technologies modify individual's behavior and change social relations significantly. Within this dynamic chain of information, we realize that many scientific studies deployed only in printed matter, were limited geographically and its contents did not have adequate visibility. This research aims to report the paths followed for the digitization of the dissertations coming from the Graduate Program in Information Science at the Universidade Federal da Paraiba (PPGCI/UFPB) and made available through the DSpace platform as a digital repository. The research universe was composed by 174 dissertations. The documents were scanned and processed using Optical Character Recognition (OCR). It can be stated that 26% of the existing dissertations are available at the PPGCI/UFPB repository. Statistics show that these dissertations are being widely accessed by the community.


BACKGROUND AND AIMS
Oral small-molecule drugs (SMDs) are expanding the therapeutic landscape for inflammatory bowel disease (IBD). This systematic review and meta-analysis summarises the efficacy and safety of JAK inhibitor (JAKi) and sphingosine-1-phosphate (S1P) receptor modulator treatments for ulcerative colitis (UC) and Crohn's disease (CD).

METHODS
MEDLINE, Embase, and CENTRAL were searched from inception to May 30, 2022. Randomised controlled trials (RCTs) of JAKi and S1P receptor modulators in adults with UC or CD were eligible. Clinical, endoscopic, histologic, and safety data were pooled and analysed using a random-effects model.

RESULTS
Thirty-five RCTs (26 UC, 9 CD) were included. In UC, JAKi therapy was associated with induction of clinical (risk ratio [RR] 3.16, 95% confidence interval [CI] 2.03-4.92; I2=65%) and endoscopic (RR 3.99, 95% CI 2.36-6.75; I2=36%) remission compared to placebo. Upadacitinib was associated with histologic response (RR 2.63, 95% CI 1.97-3.53). S1P modulator therapy was associated with induction of clinical (RR 2.52, 95% CI 1.88-3.39; I2=1%) and endoscopic (RR 2.39, 95% CI 1.07-5.33; I2=0%) remission relative to placebo. Ozanimod was superior to placebo for inducing histologic remission in UC (RR 2.20, 95% CI 1.43-3.37; I2=0%), while etrasimod was not (RR 2.36, 95% CI 0.71-7.88; I2=0%). In CD, JAKi therapy was superior to placebo for induction of clinical remission (RR 1.53, 95% CI 1.19-1.98; I2=31%), and endoscopic remission (RR 4.78, 95% CI 1.63-14.06; I2=43%) compared to placebo. The risk of serious infections was similar for oral SMDs and placebo.

CONCLUSION
JAKi and S1P receptor modulator therapies are effective in IBD for inducing clinical and endoscopic remission and, in some circumstances, histologic response.


The data driven mining technology was applied in the most of the existing behavior here we assume the strategy of domain driven data mining and utilize Real word business requirements and problems are and prospects. Data driven business world is heading—and what challenges and opportunities CEOs see in 80% place data mining and analysis as the second-most their organization's growth prospects. It's clear business domain, and analytical. showcase even more examples of domain-driven computer and data science their studies. This is a major data challenge that is also found out by text mining grant proposals. The prospects for success come down to several factors.


The study of traditional medicinal plants was conducted in Goba woreda from August to October 2018 in three kebeles Kedu, Elasa and Aloshe Tilo. In this woreda, diverse medicinal plants were used to treat human and livestock disease. Among this various medicinal plant only 35 species were collected and identified by using the Flora book of Ethiopia and Eritrea (volume 3, 1989). The data was collected from 21 informants of traditional healer and from these 7 informants healer taken from each kebele and 16 were males and 5 females. The healers were used for treat dermatological, respiratory, ureno-genital, gastro-intestinal, febrile and livestock disease in the study area by using plant part of leaf (58%), root (25%) and other part (17%) to serviceable orally, nasally or dermally. However; these plant species were threatened by the activities of the community like expansion of agriculture, overgrazing, and deforestation of plant was the risk of extinction. To conserve the area and preserve the medicinal plants it was recommended to make aware of the society and to develop in –situ and ex-situ conservation plants. Keywords: Human diseases, Livestock ailments, Traditional healer, Traditional medicinal plants DOI : 10.7176/JNSR/9-10-01 Publication date :May 31 st 2019


The directed generation of pure astrocyte cultures from pluripotent stem cells has proven difficult. Generation of defined pluripotent‐stem‐cell derived astrocytes would allow new approaches to the investigation of plasticity and heterogeneity of astrocytes. We here describe a two‐step differentiation scheme resulting in the generation of murine embryonic stem cell (mESC) derived astrocytes (MEDA), as characterized by the upregulation of 19 astrocyte‐associated mRNAs, and positive staining of most cells for GFAP (glial fibrillary acidic protein), aquaporin‐4 or glutamine synthetase. The MEDA cultures could be cryopreserved, and they neither contained neuronal, nor microglial cells. They also did not react to the microglial stimulus lipopolysaccharide, while inflammatory activation by a complete cytokine mix (CCM) or its individual components (TNF‐α, IL1‐β, IFN‐γ) was readily observed. MEDA, stimulated by CCM, became susceptible to CD95 ligand‐induced apoptosis and produced NO and IL‐6. This was preceded by NF‐kB activation, and up‐regulation of relevant mRNAs. Also GFAP‐negative astrocytes were fully inflammation‐competent. Neurotrophic support by MEDA was found to be independent of GFAP expression. In summary, we described here the generation and functional characterization of microglia‐free murine astrocytes, displaying phenotypic heterogeneity as is commonly observed in brain astrocytes. © 2011 WiWiley Periodicals, Inc.


In this paper, a novel stacked differential mode rectenna is proposed and its characteristics are experimentally evaluated. The proposed rectenna operates in a differential mode. Therefore, the proposed rectenna can effectively rectify microwave power even under low power environments. The conversion efficiency of 37.1% was obtained when the received power density was as low as 0.04 W/m2. The proposed rectenna can easily achieve large-scale rectenna arrays by simply stacking the rectifying diodes and microstrip antennas because the stacking structure does not degrade the conversion efficiency.


Alzheimer's Disease (AD) is a progressive neurological disorder, characterized by amyloid-beta (Aβ) and neurofibrillary tangles (NFTs). Recently a new factor called neuroinflammation is added which can directly play a key role in the progression of AD. The recent studies in humans and mice had shown that aggregated protein (Aβ and NFTs) binds to the microglia cells (the resident innate immune cells) found in the central nervous system and activates the innate immune response which is characterized by the release of inflammatory mediators and increase the disease progression through the neuroinflammation. Several factors such as traumatic brain injury, obesity, etc. can play a major role in neuroinflammation. Hence targeting the immune mechanism and reduce the risk factors could lead to future promising therapeutics for AD.


There is empirical evidence that households use residential houses as status goods. Their visibility qualifies them as an excellent signaling device of the relative income and wealth position, in contrast to less visible financial assets. To this end we introduce a residential housing sector and status concerns for housing into a neoclassical framework. In the model, households derive utility from the absolute amount of housing and from comparing their stock of housing to a reference stock, which is composed of the current or past level of housing of their peers. We analyze how status concerns affect household behavior and find that they increase housing demand and labor supply. Furthermore, we find that status concerns exert a negative externality and elevate housing to inefficiently high levels. We derive a (state contingent) optimal tax that establishes the first-best allocation along the transition path and at the steady state. Calibrating the model to the US we quantify the optimal tax on residential housing to 1.8%. Introducing the optimal tax entails a considerable welfare gain of 0.29% measured in consumption equivalents.


Absolute Lao Zi is Yen Zun's annotations of Lao Zi, where he explicates his understanding of Lao li based on the themes found within and constructs his own philosophical system. Yen Zun uses the idea of "nature of Tao"--with emphases on the nothingness of Tao as reality, the nature of Tao, and the flourishing of the world in harmony with nature--and re-interpret Taoist thoughts from the perspective that the way of man should be conjunct with the way of heaven; the power of his influence is certainly profound. This paper is intended to explore the followings issues in terms of the thoughts in Absolute Lao Zi: first, the "Shf- Wu" of Tao as reality shows that Tao is fundamental to the being and transcendence of world; second, it is to explain the generative principle of Tao Te, divinity, harmony and the cosmos; third, it is to point out that Absolute Tao Te advocates the self-generation of the world within the Taoist framework of Wu wei; fourth, the function of Tao is to advocate the reduction of desires and the preservation of virtue, as well as the conservation of spirit and life, to form a political philosophy of humanism and Wu wei. It's expected that these explorations can illustrate the rich meanings embedded in Absolute Tao Te and the great impact it makes.


We report on observations of the blazar W Comae (ON+231) with the Solar Tower Atmospheric Cherenkov Effect Experiment (STACEE), a wavefront-sampling atmospheric Cherenkov telescope, in the spring of 2003. In a data set comprising 10.5 hours of ON-source observing time, we detect no significant emission from W Comae. We discuss the implications of our results in the context of the composition of the relativistic jet in W Comae, examining both leptonic and hadronic models for the jet. We derive 95% confidence level upper limits on the flux at the level of 1.5–3.5 × 10 - 10 cm - 2 s - 1 above 100 GeV for the leptonic models, or 0.5–1.1 × 10 - 10 cm - 2 s - 1 above 150 GeV for the hadronic models.


BACKGROUND: Transfusion‐associated circulatory overload (TACO) is a frequent complication of blood transfusion. Investigations identifying risk factors for TACO in critically ill patients are lacking.


The objective of the study was to determine the efficacy and success of Maryland State Highway Administration's (SHA's) public service campaign regarding pedestrian safety. Data collection issues forced a change in this focus as the project progressed. The study contains two issues that are addressed for an important segment of society – elderly citizens. The results allow an examination of senior citizen attitudes concerning pedestrian safety. A survey was conducted to determine the attitudes and beliefs of senior citizens concerning pedestrian safety. The surveys were conducted at local senior centers. In addition, focus groups were conducted at six senior centers to allow the seniors to discuss these issues. Standard statistical methods were employed to analyze the survey, while the analytical framework for the focus groups was drawn from critical ethnography and studies of practice and discourse in public policy. These methodologies are discussed in detail in the report.


The introduction of Goods and Services Tax (GST) in India starting from July 1, 2017 was a landmark move in the history of Indian tax reforms. The pre-GST regime characterised by VAT rate varying between products and states bequeathed a path for GST, where the tobacco price variation across states is expected to vanish due to uniform tax rates influencing consumption and revenue from tobacco products. An analysis of the tax burden during pre-GST period and after implementation of GST has helped us in understanding that, the transition to the GST has not made any major increase in the tax burden on the cigarettes. Even the GST compensation cess have not made any drastic increase in the tax burden on cigarettes. On the contrary, the post-GST tax structure on cigarettes is claimed to be burdensome by major cigarette producing companies in India. In the light of these conflicting views, it is imperative to assess impact of GST on the affordability of tobacco products.We employ the affordability index developed by Bletcher and van Walbeck (2004) using Relative Income Price (RIP) on tobacco and non-tobacco products for the time period between 2014-15 and 2017-2018. The study finds that in the post-GST period, for majority of the study states cigarettes have become less affordable. This isdue to a fall in income counteracted against price increases. For majority of the study states, beedi has become less affordable during the post-GST period. This is due to price increases counteracted against income decreases. And finally for non-tobacco products, in post-GST period, the affordability of rice, wheat and egg has increased in majority of the states. In case of rice and egg, this effect is due to increases in income counteracted against price increases. On the other hand, in case of wheat the result was due to increases in income coupled with fall in wheat prices


Ampholine pH 4–6 and Pharmalyte pH 4.2–4.9, 4.5–5.4 or 5–6 have been used to improve the resolution of the simplified technique of high resolution two‐dimensional electrophoresis. All give excellent resolution but Pharmalyte interferes with protein detection methods to an extent which increases with the pH range of the mixture. The effect is characterised by a progressive increase in the intensity and area of background stain associated with the anode and cathode regions of the two‐dimensional gels. It is minimal following Serva Blue R (Coomassie Blue) staining but severe following silver staining.


Water-stressed plants accumulate abnormally large amounts of free proline, a protein component. Blue grama (Boutelouagracilis) was clipped and water-stressed to test whether the degree of proline accumulation might be related to regrowth potential of . range grass. Clipping of plants before stress reduced the accumulation of proline in bases of stressed shoots but increased herbage production; clipping after stress speeded the decrease of accumulated proline in shoot bases.


The article presents the current status of the revision of EN 1993‐1‐11 with regard to the design of saddles and clamps for ropes or for parallel wire tension components for suspended structures. The focus here is on presenting a general approach for clamps. For saddles, emphasis is on types where the slip resistance is – in addition to the component from deviation forces – increased by clamping forces, although general aspects are also covered. The starting point is a (retrospective) look at the provisions in national standards and guidelines as well as in the current version of EN 1993‐1‐11 (2006). Subsequently, the new provisions are presented, and the different new coefficients are explained in detail.


Introduction: Breast cancer is a common malignancy among female in Bangladesh.But its molecular subtypes are not evaluated due to lack of expert investigationsupport. So objectives of the present study are to evaluate the molecular subtypesof breast cancer patients according to St Gallen classification in our contest.
Materials and methods: It is retrospective study done among histopathologicallyproved 40 breast cancer patients visiting Medical Oncology and Radiotherapydepartment of Chattogram Maa-O-Shishu Hospital. Molecular subtypes wasevaluated by immunohistochemistry according to St Gallen Classification.
Results: In this study a total of 40 cases of invasive female breast cancers wereincluded. Age of the patients ranged from 31-62 years, with a mean age of 41 ±13.5 years. ER expression was seen in 60% and PR in 55% of cases and Her-2/neupositivity in 16%. Majority (52.5%) of the tumors were located in the left breast. Thepercentage of ER but not PR positivity increased with age, though this differencewas not statistically significant. Majority of the cases were diagnosed at stage IIwith a percentage of 42.5%. Stage II tumors showed more ER and PR positivity.Among all 57.9% of ER positive and 49.5% of PR positive tumors were present while72.2% of tumors were negative for Her-2/neu. The triple-negative breast tumorswere more commonly found at grade 2. Regarding luminal status 14(35%) wasLuminal A, 5(12.5%) was Luminal B, 9(22.5%) was TNBC and 12(30%) was HER 2positive.
Conclusion: In this study luminal A was the commonest molecular subtypes. LuminalA subtypes tumors had a long term risk of distant matastatic disease which can bereduced by hormonal treatment.
Chatt Maa Shi Hosp Med Coll J; Vol.19 (1); January 2020; Page 55-58


Non-randomized studies indicated significant correlation between revascularization and improvement of survival in patients with left ventricular systolic dysfunction and preserved myocardial viability. Almost 80% reduction of 1-year all-cause mortality was observed. This benefit was inversely correlated with left ventricular ejection fraction. However, thorough analysis of the STICH trial — with all its limitations — indicate no association between preserved myocardial viability and predicted benefit of surgical revascularization. These conflicting data signalize that the assessment of myocardial vitality cannot be the only determinant in choice of the best therapeutic option in patients with ischemic heart failure. Hence, a well-controlled IMAGE-HF trail was planned. The authors hypothesized, that advanced cardiac imaging techniques, including anatomical ones such as CMR and PET/CT will be more accurate in the identification of patients who benefit from coronary revascularization as compared with SPECT imaging. Nevertheless, at present, there is lack of arguments for discontinuing myocardial viability assessment before qualification for revascularization in patients with ischemic heart failure. Taking into account all limitations of myocardial viability assessment, we are aware of very high mortality rate in this group of patients, which tells us to exhaust all opportunities that could improve their prognosis.


Classic selective sweeps occur when positive selection increases a variant's frequency from low to high in a population, and underlie some long‐studied human characteristics such as variation in skin, hair or eye colour. In such well‐studied 'gold standard' examples, a known variant has been associated with a plausible phenotype and underlying selective force. Signatures of classic sweeps have more recently been detected in population‐genetic data independently of any prior information about the corresponding phenotype or selective force, and usually without suggesting any insights into these. Motivated by the need to understand such candidates, we first review the gold standards and show that our understanding of them is often incomplete or unconvincing; only two of the examples we consider are compellingly explained. We assess approaches for large‐scale association of classic sweep candidate variants to phenotypes and selective forces, test these on the gold standards, and discuss the standards of evidence needed to adequately understand a selective sweep.


The increasing rate of online shopping and online search of information about products and services has made online reviews or E-Word of Mouth (E-WoM) a common phenomenon with consumers. User generated opinions and information are gaining acceptance from prospective customers while they browse online for goods and services. Consumers often seek online user generated reviews to make offline purchase decisions as well. As online retail has picked up pace in India in recent years, the role of user generated content in the online space has become more relevant. This paper attempts to study the aspect of buying behaviour of customers and focus on how the upcoming users are utilizing E-WoM before making ISSN: 0971-1023 | NMIMS Management Review Volume XXXIV | Issue 1 | April 2017 ISSN: 0971-1023 | NMIMS Management Review Volume XXXIV | Issue 1 | April 2017 Antecedents to Customer Acceptance of Information in E-Word of Mouth Antecedents to Customer Acceptance of Information in E-Word of Mouth or abandoning a purchase. In this study, product ranking emerged as the strongest antecedent to customers' acceptance of information in E-WoM. Additionally, the study brings out that highly involved customers pay attention to the number of reviews written online, their timeliness as well as how accurate they are. An online retailer may rearrange his merchandise, especially in terms of displaying the products, on the basis of reviews and ranks he gets for his merchandise.


A magic square of 3×3 and its multiples i.e. (9×9) squares and so on, of order N are composed of (n×n) matrix having filled with numbers in such a way that the totals sum along the rows ,columns and main diagonals adds up the same. By using a special geometrical figure developed.


This thesis designs a Koch dipole antenna operating in multiple frequency band with radio frequency(RF)switch,by combining Koch fractal dipole antenna with RF switch.The antenna can work at several frequency bands by controlling RF switch.Compared with common dipole antennas,the length of Koch dipole antenna is reduced significantly.The simulation results based on HFSS software indicate that the designed antenna has good performances in several different frequency bands.


Artemisitene (ATT) activates the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) by increasing its stabilization and reducing ubiquitination. The cysteine (Cys) residues of the cytosolic Nrf2 repressor Kelch-like ECH-associated protein-1 (Keap1) function as redox sensors and may be crucial in activating Nrf2. To determine whether ATT-induced Nrf2 activation is dependent on the modification of Keap1 and to elucidate the underlying mechanism, we transfected cell lines with six different Keap1 mutant constructs, each with a Cys (−77, −151, −257, −273, −288, and −297) to Ser substitution. Only the Cys151Ser mutant prevented ATT-mediated activation of Nrf2, indicating that the Cys151 residue of Keap1 likely interacts with ATT and is essential for Nrf2 stabilization and transcription of downstream genes. Our finding provides a pharmacological basis for using artemisitene against oxidative stress-related diseases.


INTAN HAFIZA. Analysis of the binding of active pare molecular compound (Momordica charantia) to the Maltase Glucoamylase Enzyme for Anti-Diabetes Agents. Supervised by TONY IBNU SUMARYADA and AGUS KARTONO. Molecular Docking with receptors is a well-known computational method used to predict interactions between two molecules. Phenolic bitter compounds (Momordica charantia) have been shown to have efficacy in the treatment of diabetes but the potential of each of these compounds is unknown. The control used for the comparison material for the test ligand is miglitol. The parameters analyzed were binding energy (∆G), inhibition constant (Ki), and binding site similarity (BSS). The phenolic compounds that being explored in this study were glitazone, pioglitazone, voglibose, ferulic acid, gallic acid, caffeic acid, pcoumaric, gentisic acid, chlorogenic acid, cianidanol. Simulation results show that antioxidant flavonoids cianidanol can inhibit maltase glucoamylase enzyme activity with binding energy values of -6.7 kcal mol-1 compared to miglitol binding energy worth -5.4 kcal mol. The percentage of BSS of the cianidanol compound compared with the miglitol control ligand of 94.73% indicates that the positioning is almost similar and has a similar mechanism as miglitol. It can also be concluded that flavonoid compounds are natural maltase glucoamylase inhibitor.


Occupied Regions of Genomes from Affinity‐purified Naturally Isolated Chromatin (ORGANIC) is a high‐resolution method that can be used to quantitatively map protein‐DNA interactions with high specificity and sensitivity. This method uses micrococcal nuclease (MNase) digestion of chromatin and low‐salt solubilization to preserve protein‐DNA complexes, followed by immunoprecipitation and paired‐end sequencing for genome‐wide mapping of binding sites. In this unit, we describe methods for isolation of nuclei and MNase digestion of unfixed chromatin, immunoprecipitation of protein‐DNA complexes, and high‐throughput sequencing to map sites of bound factors. © 2015 by John Wiley & Sons, Inc.


Objective:To study the spinal cord injured patients postoperative rehabilitation therapy. Methods: the 41 cases, All of the patients were performed Chinese medicine, acupuncture, taken orally liquid form such as physiotherapy rehabilitation therapy. Results: After the TCM comprehensive therapy, the patient all have different degrees of improvement. Conclusion: rehabilitation therapy in traditional Chinese medicine of spinal cord injury rehabilitation therapy has positive function.


Anticipating what might happen as a result of an action is an essential ability humans have in order to perform tasks effectively. On the other hand, robots capabilities in this regard are quite lacking. While machine learning is used to increase the ability of prospection it is still limiting for novel situations. A possibility to improve the prospection ability of robots is through simulation of imagined motions and the physical results of these actions. Therefore, we present URoboSim, a robot simulator that allows robots to perform tasks as mental simulation before performing this task in reality. We show the capabilities of URoboSim in form of mental simulations, generating data for machine learning and the usage as belief state for a real robot.


The suitability of dimethyl ether as a C1 compound was examined with the obligate methylobacterium Methylococcus capsulatus (Texas). The ether did not support growth and was not formed during growth on methane; it was an inhibitor of growth and oxidation of methane and a poor oxidation substrate for cell suspensions. NADH stimulation of methane, but not dimethyl ether, oxidation occurred in cell extracts.


A side-to-side arteriovenous fistula, created between the radial artery and the cephalic vein, has been recommended as the standard procedure for establishing vascular access for chronic haemodialysisv:". Venous hypertension affecting the hand can occur in 4to 10% of patients with this type of fistula confi~uration5.1O.11. Venous hypertension represents a clinical entity the manifestations of which. closely resemble those of chronic venous insufficiency of the lower limbs. Common symptoms include hand pain (sore-thumb syndrome), pigmentation chan~es, and stasis ulcersti.II.14. Surgical management is fairly simple and consists of ligation of the distal portion of the cephalic vein. Postoperatively, hand pain and oedema readily disappear and stasis ulcers usually heal after a few weeks.


With the rapid development of globalization, the advanced oral Chinese curriculum becomes more and more important in international education for the foreign students of the senior class in China. Aiming to address the problems in the teaching of oral Chinese curriculum, this paper uses the literature method, comparative analysis method, and survey method to study the advanced oral Chinese teaching mode under the constructivism theory. With the guidance of constructivism theory, this paper concludes and provides three teaching modes including scaffolding mode, interactive mode, and task-based mode by analyzing oral Chinese teaching cases. The construction of the three teaching modes can do more effective functions on the advanced oral Chinese curriculum for the international education teachers to use.


Bionic ionic skins, having ionic transduction and chromotropic trait as chameleons, along with multiple sensing, antibacterial, self-healing, and anti-freezing functions, are of great importance in a wide range of applications,...


Mount components prevents the tilting on the multilayer substrate. Multilayer substrate according to the present invention includes a body having a major surface, it is provided on the main surface, and the external electrodes of the first external electrode through the n, provided element body and the other conductor is connected a first dummy layer not provided with a, when viewed from the normal direction of the principal face, the external of the m of the external electrodes of the m of the first external electrode to the external electrode of the n the distance to the nearest external electrodes to the electrodes is defined as the distance Dm, the average of the distances D1 to the distance Dn is defined as the average Dave, when viewed from the normal direction, the distance Dm around the external electrodes of the m defines a circular area whose radius and area (Am), the first dummy layer, when viewed from the normal direction, a region small distance Dm radius than the average Dave of the (Am) at least it is provided in the partial region (Am), characterized by.


Using a higher categorial interpretation of entanglement involving gauge theories and σ -models instead of qubits, one recovers T-duality as a form of ancilla aided entanglement generation. This opens the way towards new dualities in gauge theories and σ -models produced by means of analogies with quantum circuits of various types.


Probabilistic load flow(PLF) calculation is an important tool for power system steady state performance analysis.Most of the existing PLF methods require to know the probability distribution functions of input random variables,which are very difficult to be modeled accurately.In the paper,a PLF method based on polynomial normal transformation and Latin hypercube sampling was proposed.This method used the numerical characteristics of input random variables to establish their probability distribution models by polynomial normal transformation technique,and then adopted Monte Carlo simulation method based on Latin hypercube sampling to obtain the numerical characteristics and probability distribution curves of bus voltage and branch power.The validity of proposed method was tested on IEEE 30 bus system and IEEE 118 bus system.The simulation results show that the proposed method is effective,which not only has the advantages of fast computation,high accuracy and good robustness,but also can deal with the correlation between input random variables flexibly.The proposed method is of some practical engineering value.


Remdesivir (GS-5734) is a valuable nucleoside RNA polymerase inhibitor, which is considered to be a potential drug for curing COVID-19 and has been used in clinical trials now. In this paper, six potential RNA polymerase inhibitors were compared with Remdesivir based on the density functional theory (DFT). By comparing electronic structure properties of the chosen inhibitors with Remdesivir, it is found that the dipole moment, energy gap, and conceptual density functional parameters of compound 6 were similar to those of Remdesivir, indicating its potential of serving as inhibitor of SARS-CoV-2 RNA polymerase. Moreover, the potential inhibitory ability of compound 6 against SARS-CoV-2 was further confirmed by molecular docking study. This paper is expected to provide a quantum chemical computation aided strategy for further screening drug candidates.


A 34-year-old male was referred to our hospital for drainage of symptomatic pancreatic fluid collections (PFCs) secondary to an acute pancreatitis. He was affected by gastro-duodenal and biliary obstruction. CT scan images revealed 1 perigastric pseudocyst (well-defined wall, without necrosis content, 70 x 120 mm) and 1 periduodenal walled-off pancreatic necrosis (WOPN) (thickened wall, partially liquefied collection containing solid content, 80 x 90 mm). Both PFC were accessed under endoscopic ultrasound (EUS)-guidance with a 6 Fr-cystotom and dilation tract using a 10 mm balloon (Fig. 1). First, the pseudocyst was drained transgastrically with a fully covered SEMS with bilateral anchor Double endosonography-guided transgastric and transduodenal drainage of infected pancreatic-fluid collections using metallic stents