Peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors of the nuclear hormone receptor superfamily. They were originally identi®ed as molecular targets for compounds that induce an increase in size and number of hepatic and renal peroxisomes in rodents, together with a concomitant increase in the capacity of peroxisomes to metabolize fatty acids via increased expression of the enzymes required for b-oxidation. PPAR appear to act as messengers responsible for translating nutritional, pharmacological and environmental stimuli into changes in gene expression and cellular differentiation pathways [1,2]. They have also been shown to activate steroid hormone receptors [3]. Three isoforms of PPAR have been identi®ed. Termed a, d (or b) and g, they are encoded by different genes and show distinct tissue distribution [1,2].


12 architectural drawings of two prominent palaces in Courland (now Latvia), namely in Mitau (Jelgava) and Ruhental (Rundale) are to be found in the Tessin-Hårleman Collection (THC) of Nationalmuseum in Stockholm, one of the most famous gatherings of architectural drawings in Europe. They are kept in the so called Bergholtz collection which is a part of THC. The drawings of two Courland palaces make this collection of special interest for the art of the Baltic region. Who was the creator of the collection, what was the reason to compile it and what other drawings are stored there – these are the first questions to be answered in this article. Friedrich Wilhelm von Bergholtz (1699–1771) is a well-known person in Russian history of the 18th century. Born in the German Duchy of Holstein, he made three long-term visits to the Russian empire during the first half of the century, spending about 15 years there in total. The first stay (1709–1714) was connected with his father's military service for Peter the Great, as a general-lieutenant, who took part in the Northern war. In 1721–1727 Friedrich Wilhelm von Bergholtz stayed at the


Continuous-wave losing was achieved at temperatures up to 70°C in mesastripe AlGaAs heterojunction lasers consisting of stripes 10-μ wide (emission wavelength 835-845 nm) attached on the substrate side to a copper heat sink. This made it possible to achieve a thermal resistance not exceeding 40°K/W in spite of an increase in the length of the heat sink. Moreover, the diode assembly became easier and it was possible to eliminate completely the distortion in the angular distribution pattern. The minimum transverse current was 58 mA at 25°C and the maximum power was up to 30 mW. Life tests showed only slight changes in the output power in a period of 450 h at 70°C.


In order to fetch a large number of instructions per cycle, wide-issue superscalar processors have to predict the outcome of multiple branches in a cycle, and fetch instruction blocks from multiple targets. This paper investigates a control flow prediction scheme that predicts the outcome of multiple branches by performing a single prediction. Instead of predicting the outcome of each individual conditional branch, this scheme considers a tree-like subgraph of the control flow graph of the executed program as a single prediction unit, and predicts the target of a subgraph at a time, thereby allowing the superscalar fetch mechanism to go past multiple branches per cycle. This approach is evaluated using the MIPS architecture, for a 12-way superscalar processor, and an improvement in effective fetch size of more than 50%, over an identical processor that uses branch prediction is observed for the SPEC integer benchmarks. No appreciable difference in the prediction accuracy was observed although the control flow prediction scheme predicted one out of four outcomes.


The term fatigue refers to a condition characterized by extreme body, psychic and mental exhaustion that is neither induced by body activity, reduced body efficiency nor reduced energy. In contrast to normal body exhaustion as result of body or mental effort, tumour related fatigue occurs even without or with very little body activity and tends not to improve by either rest or sleep. In the last years, the problem of tumour related fatigue has generated more interest in the scientific and clinical fields. In the clinical picture of patients, a differentiation is made between acute and chronic fatigue. Acute fatigue occurs during or immediately after undergoing chemotherapy or radiotherapy. Chronic fatigue can occur several months or years after the completion of the therapy. This is related to how the patient copes with the disease or long term adaptation challenges. In the present scientific discourse, fatigue is considered to be a multidimensional concept encompassing bodily, cognitive and affective aspects


Hemoglobin D disease in a Christian family of Indian ancestry is described. A boy 10 years of age and his mother were found to have the disease.


The article is devoted to analysis of features of cognitive processes of adolescents with somatoform autonomic dysfunction in comparison with healthy adolescents. Methods used: the Stroop test to assess the emotional component of perception, the method of "10 words" to study the dynamics and specificity of memory, semantic differential to study the characteristics of emotional relationship to neutral and emotionally significant stimuli. 166 adolescents aged 13 to 17 years has been studied: 106 adolescents with somatoform autonomic dysfunction, 60 adolescents of the control group. The huge role of emotional component in the process of perception, the specific features of attention and memory in adolescents with somatoform autonomic dysfunction and their differences from healthy adolescents was defined. Age analysis revealed more pronounced disorders in younger adolescents compared with older. In adolescents with somatoform autonomic dysfunction concomitant somatic diseases are observed more expressed disturbances.


Theoretical and experimental investigations have been
made to determine the effect of temperature (in the
range of 27°C - 55°C) on the accuracy of moisture
measurement in hevea rubber latex. The measurements
are based on the microwave attenuation, operating at
9.5 GHz.
The results show that microwave attenuation is
affected by temperature and variation of temperature
of a few degrees in the latex may introduce
inaccuracies of more than 5% in water content
measurements.


The author discusses the mythical presentations about the existence of two autonomous, different and opposing realities - this world and that world - the first of which is always marked as "ours" and human, and the second one as a strange and a distant world of demoniac creatures.


Spam mail management in universities differs from that in enterprises having uniform and strict network policy, and requires the guarantee of a free policy of mail environment. In this paper, we report on the findings from the operation experiment of adopted spam mail filtering based on the volunteer application of users to the management. In particular, management of the electronic mail (email) delivery delay problem is picked up under the consideration of the state of the email usage in our university. We also discuss an ideal method of the spam mail filtering in universities and in research institutes under the free policy of mail environment.


In order to explore the influence of the peritoneal transport on the effect of peritoneal dialysis. 21 patients with continuous ambulatory peritoneal dialysis(CAPD) was analyzed. The effect of dialysis was evaluated by the method of KT/V and Ccr in order to examine the effect of peritoneal transport on peritoneal dialysis. Conclusion: The function of peritoneal transport plays an important role in the effect of peritoneal dialysis.


Biochemistry courses have an important place as a common subject in faculties of medicine, food engineering, biology and chemistry. MSLQ, Metacognitive Awareness Inventory and Learning Approach Questionnaire were used. The study also involves repeated observations of the same instructor in a biochemistry class over eight weeks to describe students' academic performance, instructor practice, teaching methods and generally, learning environment in the biochemistry class. Students achieving the two highest scores, two average scores and the two lowest scores from biochemistry exams were selected for in-depth interviews and results demonstrated that self-efficacy, intrinsic goal orientation, task-value, cognitive strategies such as critical thinking ability and elaboration, metacognitive self-regulated strategies and effort regulation may have a considerable importance in students' biochemistry achievement. Results of the study also revealed that levels of students' awareness of what and how they monitor in their biochemistry learning process has an important effect on their biochemistry success.


Random sequences play an important role in cryptographic research.NIST published 16 standard tests to test the randomness of binary sequences in March 2001,and test for the longest-run-of-ones in a block and overlapping template matching test are included in the 16 tests.Most analysis are focused on longer random sequences,this paper analyzes short random sequences and makes a comparison of these two kinds of test.


On 15 April 2016, the Kumamoto earthquake (Mw 7.3) occurred in Japan with no warning signals. Global Navigation Satellite System (GNSS) receivers provide useful information on disturbances in the ionosphere by calculating the changes in total electron content (TEC), which is the number of electrons in the ionosphere. Here we show our recently proposed correlation analysis of TEC data which can detect the preseismic ionospheric anomalies from the public GNSS data. Our method detected the ionospheric anomaly several tens of minutes before the 2016 Kumamoto earthquake near its epicenter. Furthermore, we gave an indicator to distinguish between the preseismic TEC anomalies and the medium‐scale traveling ionospheric disturbances (MSTIDs) by calculating the anomalous area rates. These results support the hypothesis for existence of the preceding phenomena before large earthquakes.


A prominent effective description of particles interacting with the quantum properties of gravity is through modifications of the general relativistic dispersion relation. Such modified dispersion relations lead to modifications in the relativistic time dilation. A perfect probe for this effect, which goes with the particle energy cubed $E^3$ over the quantum gravity scale $E_{\text{QG}}$ and the square of the particle mass $M^2$ would be a very light unstable particle for which one can detect the lifetime in the laboratory as a function of its energy to very high precision. In this article we conjecture that a muon collider or accelerator would be a perfect tool to investigate the existence of an anomalous time dilation, and with it the fundamental structure of spacetime at the Planck scale.


Standard client-server workflow management systems have an intrinsic scalability limitation: the central server is a bottleneck for large scale applications. It is also a single fault paint that may disable the whole system. We propose a fully distributed architecture for workflow management systems. It is based on the idea that the case (an instance of the process) migrates from host to host, according to the process definition specification, as the corresponding activities are executed. This basic architecture is improved so that other requirements for Workflow Management Systems, besides scalability, are also contemplated. A CORBA-based implementation of such architecture is discussed, with both its limitations and positive points described.


xii CHAPTER ONE: INTRODUCTION 1 Motivation 1 Molecular dynamics 3 The classical Hamiltonian for a molecular system 3 Potential energy term 4 Kinetic energy term 9 The radial distribution function (RDF) 13 Thermodynamic background 14 Phase Space and Statistical Thermodynamics 14 Thermodynamic Cycles 15 Free energy perturbation method 17 Determination of the solvation free energy 19 Molecular mechanics models 22 Non-polarizable MM force fields 22 Models used in this work for Mg and Zn 27 CHAPTER TWO: SOFTWARE 34 Simulation methods 34 Developed program code 35 CHAPTER THREE: RESULTS 39 Parametrization of DC force fields for Mg and Zn ions 39 Relationship between ∆Gsolv(Zn ), RDF (M-O) and parameter values 42 Comparison of SC/TIP3P, DC/TIP3P and continuum dielectric models 47 ZnF2(H2O3) cluster in gas phase 54 CHAPTER FOUR: DISCUSSION 60 CHAPTER FIVE: CONCLUSIONS 66 APPENDIX A: FORCE FIELD PARAMETERS 68


Objecive: To investigate the role of detecting plasma viscosity in different shear rates for hemorheological analysis. Methods: The index of plasma viscosity(PV) at 30 ℃ in a shear rale of 110 sec-1 to 10 sec-1 was determined from 18 exercisers for 5 KM by LIANG-100 TIPE viscometer. Meanwhile the index of PV in the fixed shear rate was determined by role method. Results: The index of PV was increased significantly wilh shear rale decreasing. The index of PV in the fixed shear rale is higher than the one in 110 sec-1 shear rales but lower in 10 sec-1 shear rate. The PV in the shear rates of 10 sec-1 and 20 sec-1 after exercise were higher than the one before exercise,but no remarkable difference of the PV in shear rales of 40 sec-1 to 110 sec-1 and in the fixed shear rate could be found between before exercise and after exercise. Conclusions: At 30 ℃ the index of PV in a lower shear rale were increased with shear r-ate decreasing, Determining PV in different shear rales is the requisites of non-Newtonians, it may express the miner change of PV.


This datasheet on blue eye disease covers Identity, Overview, Associated Diseases, Pests or Pathogens, Distribution, Hosts/Species Affected, Diagnosis, Pathology, Epidemiology, Impacts, Prevention/Control, Further Information.


The amount of data produced by different sectors in past few years has seen an exponentially increase. As a result, professionals are struggling to process vital data in this new competitive environment. The main purpose of this research study is to understand, explore and provide important insights in the big data analytics (BDA) implementation in different functions of logistics and supply chain management (L&SCM) by conducting a bibliometric analysis and future review of relevant articles to write a literature review on trends and implementation of BDA. The study performs a literature review based on the understanding of bibliometric analysis to further state the review on application and opportunity BDA in logistics management and supply chain management (SCM). The motive of this research study aims to find the advantages of adopting BDA, study the inadequate research findings which was not mentioned in previous research papers in this field. Further the literature review categorizes the trends and implementation of research topic in nine main functions of logistics as well as SCM. This research study will help the practitioners and academia with insightful observation on research finding, applying and incorporating BDA for managers and supply chain (SC) professional to take decision whether use of analytics will help to improve SC and is in vesting in BDA a good decision. Also, the article indicates the scope of future study by highlighting the trends in use of analytics and how this implementation in various functions of SC can be further studied based upon the research gap and future direction. This article is unique in terms on conducting bibliometric study since the evolution of big data concept, analyze the trends, interpret and further with the process of literature review showcase a theory regarding the use of the analytics technology in logistics and SC domain.


5 Top 20% manufacturing firms in China produce about 90% of industrial output, compared to over 96% in 6 United States. Using China NBS industrial firm-level dataset, we confirm the missing of large firms in a novel 7 dimension in number of products. While being large and old, multi-product firms are fewer and smaller in China. 8 To account for this difference, we study driving factors behind firms' changes in product scopes. We find that 9 firms with a higher human capital, especially in terms of undergraduate employees, are more likely to both add 10 and drop products. After adding products, their sales growth are higher compared to firms with a low human 11 capital. The mechanism is through a higher sales-generating productivity given the same input of management 12 and operation expenses. We incorporate the findings into the product-scope-choice model of Bernard, Redding, 13 and Schott (2010), in order to quantify how much the scarcity of human capital in China can account for the China14 U.S. difference in firm sizes and product scopes. 15 JEL Codes: E44, L11, O11 16 ∗Email: firstname.lastname@example.com. †Email: email@example.com.


In renal failure, the concentrations of low molecular weight (LMW) plasma proteins (MWt < 50 OOO) may be increased in the serum due to reduced filtration, and increased in the urine because of impaired tubular uptake., Because of the sensitivity of the changes in their concentrations in both serum and urine, LMW plasma proteins, particularly &microglobulin (&M), have been used for the assessment of glomerular and tubular function. Following doubts about the reliability and stability of &-M measurements in the urine and the increase in serum concentration of &-M in several other clinical situations independent of renal function, retinol binding protein (RBP; MWt 21 OOO)z and a-1 microglobulin (alM; MWt 33OOO),' which are relatively more stable in body fluids, have been suggested as the preferred alternative indicators. We measured RBP and a ,M levels in serum and urine in patients with varying degrees of renal failure in an attempt to assess their relative sensitivity in monitoring renal function.


The article presents the results of the studies related to the development of hardening, antifriction, heat-resistant, corrosion-resistant coatings. There have been considered the models of concentration supercooling associated with the presence of a radial concentration gradient of metal nitride impurity; Benard cells, the occurrence of which is caused by the presence of a vertical temperature gradient; a cellular dislocation structure associated with the presence of plastic deformations in the coating; the emergence of auto-waves in the most diverse environments, including living beings. From the studies presented in the work, it follows that self-organization of forming coatings can occur only under conditions of a large value of the surface energy.


A novel complex, [(Cu2L4(CH3OH)(H2O)]·1/2CH3OH·H2O (HL = 2-furoic acid), was synthesized and characterized by elemental analysis, IR spectroscopy, and X-ray single-crystal diffraction. The title complex crystallizes in monoclinic, space group P2(1)/c with a = 10.2035 (12) Å, b = 13.1875 (17) Å, c = 20.069 (3) Å, a = 90°, b = 90.1460 (10)°, g = 90°, V = 2700.4 (6) nm3, Z = 2, F(000) = 1332, S = 1.053, Dc = 1.612 g·cm−3, R 1 = 0.0664 ((I > 2σ(I)), wR 2 = 0.1772, μ = 1.648 mm−1. Theoretical study of the title complex was carried out by Density Functional Theory B3LYP method. CCDC: 921325.


To the editor:

Mutations in the genes isocitrate dehydrogenase 1 and 2 ( IDH1/IDH2 ) have been recently identified in gliomas and acute myeloid leukemia (AML).[1][1] We and others reported that IDH1 R132 mutations were associated with normal karyotype and nucleophosmin 1 gene ( NPM1 ) mutations. In


Reactivity controlled compression ignition (RCCI) is a combustion strategy that offers high fuel conversion efficiency and near zero emissions of NOx and soot which can help in improving fuel economy in mobile and stationary internal combustion engine (ICE) applications and at the same time lower engine-out emissions. One of the main challenges associated with RCCI combustion is the difficulty in simultaneously controlling combustion phasing, engine load, and cyclic variability during transient engine operations. This thesis focuses on developing model based controllers for cycle-to-cycle combustion phasing and load control during transient operations. A control oriented model (COM) is developed by using mean value models to predict start of combustion (SOC) and crank angle of 50% mass fraction burn (CA50). The COM is validated using transient data from an experimental RCCI engine. The validation results show that the COM is able to capture the experimental trends in CA50 and indicated mean effective pressure (IMEP). The COM is then used to develop a linear quadratic integral (LQI) controller and model predictive controllers (MPC). Premixed ratio (PR) and start of injection (SOI) are the control variables used to control CA50, while the total fuel quantity (FQ) is the engine variable used to control load. The selection between PR and SOI is done using a sensitivity based algorithm. Experimental validation results


Based on the integral application of genetic algorithm with real number code and improved BP artificial neural network, an optimum inversion method is proposed. By numerical analysis, the availability of this method for inversion analysis of the initial stress field in rock masses and the material parameters is discussed. In calculation example, the calculative data of Burgers model is used as training sample and the inversion parameter vectors are searched by genetic algorithm. The calculation result indicates that the optimization of artificial neural network weight can increase the efficiency and reliability of artificial neural network calculation .The application of this method to inversion analysis of the rock initial stress field and material parameters has the following advantages: calculation stabilization, prompt convergence and preferable precision. By all appearances this application is valuable.


Presents the development of crime fiction in French cultures from the mid-nineteenth century onwards and explores the distinctive features of a French-language tradition.


A growing number of multinational companies are changing their place of incorporation from the United States to foreign jurisdictions. By doing so, companies are able to reduce taxes paid to the U.S. government on their foreign operations. They do not typically change their actual business structure, and they continue to pay taxes on U.S.-source income to the federal government. A number of bills have been introduced in Congress to stop such corporate "inversions" or "expatriations." Unfortunately, those bills offer only a superficial response to issues raised by the inversions and do not tackle the underlying problems caused by the U.S. corporate income tax. A recent U.S. Treasury report provides a more thoughtful, even though incomplete, response to the corporate inversion trend. The report recognizes that inversions raise broad issues related to business tax burdens and calls for a comprehensive reexamination of U.S. international tax rules. Corporate inversions are part of a broader dynamic of rising global tax competition. U.S. policymakers have so far not formulated a response to this powerful and liberating force in the world economy. Instead, they occasionally apply Band Aids to corporate tax issues raised by the media, but put off long overdue fundamental tax reforms.


Introduction - early-modern England Africa the African on the Elizabethan stage Elizabethan poetics of blackness the African on the Jacobean stage Jacobean poetics of blackness early-modern tropes of blackness.


The medical field has wide career preferences as the medical world develops, making it attractive for students to study medicine. The breadth of career preferences in the medical field exposes students to various career options according to their wishes and abilities. Insight into medical career preferences will help students determine the right medical career. This study aims to determine the determinants of career preferences of medical preclinical students in general in Indonesia. This study used a method descriptive cross-sectional. The data is the result of the questionnaire in accordance with the inclusion criteria of the sample. The number of samples obtained was 145 medical preclinical students at the Faculty of Medicine, Udayana University. From the results of the study, it was found that 138 students (95.2%) chose a career as a clinician and 7 students (4.8%) chose a career as a non-clinical doctor. Students who choose clinicians, choose a pediatrician and internal medicine specialist as many as 22 students (16.2%). Pre-clinical blocks that are preferred by students are Behavior 87 students (60%) and Endocrine 24 students (16.6%). Parental background, cost, and time required for further education are not obstacles for respondents to choose their career preferences.


Mixture models are used extensively for the description of the mechanical behaviour of biological tissues. Because of their increasing complexity there is a need for new methods to validate the models and to determine the material parameters in the constitutive equations of the individual components and their interaction.In the paper a mixed numerical experimental method to detennine the material parameters in bipllasic mixlure is summarized and a recursive estimat.ion algorithm is derived to estimate parameters for biphasic mixtures. In a simulation it is shown that an inverse analysis to determine 4 material parameters can be done in a CPU-time of the order of one single direct analysis. Moreover, some results of experiments with a synthetic model material are discussed. The latter were used to validate a tri-phasic material model and have shown that the theory according to Snijders [7) is not complete.


222 I CUTIS WWW.MDEDGE.COM/DERMATOLOGY D ermatology certainly is the most visual medical specialty. In the current era of powerful electronic imaging and laboratory techniques, the skills of physical diagnosis seem to have become less important in medicine—not so in dermatology, in which the experienced clinician is able to identify many conditions by simply looking at the skin. Of course, dermatologists do heavily rely on dermatopathologists to microscopically visualize biopsies to distinguish diseases. Even as we acknowledge the dominant role of visual recognition, there is increasing progress in making clinical determinations based on molecular events. The era of genomic dermatology is here.


with Small Design of Video Service Engine with SCSI Interface 3.b for An ADSL-based Near Video on Demand System Chi-Shoung Huang ',* Wen-Deh Wang Huang-Cheng Huang ' Yinyi Lin Liang-Wei Lee ' Yin-Hwa Huang ' Chang-Chi Lai ' Bing-Shan Chien ' Yu-Chyuan Chang ' Chi-Shi Liu ' Bor-Sheng Jeng ' Applied Technology Laboratory Telecommunication Laboratories, Chunghwa Telecom Co., Ltd. 12, Lane 551, Min-tsu Rd, Sec. 3, Yang-Mei, Taoyuan 326, Taiwan, R.0.C Department of Electncal Engineering National Central University Chung-Li, Taiwan 32054, R.O.C. A design of video service engine Computer System Interface (SCSI) for an ADSL-based Near Video On Demand (NVOD) system is presented in this paper. In this work, the design of video service engine which provides 504 program channels at a T1 rate is proposed. The system architecture, hardware design and performance test are included here. A field trial for the proposed system is applied in Taipei, R.O.C. From the performance test, a reliable and low-cost quality of service(QoS) is achieved.


The primary text upon which we focus during the seder is the parsha in Ki Savo, "Arami Ovaid Avi; (my father was tricked by an Aramean)" (Devarim 26:5), which also served as the text which would be recited by those who would bring bikkurim (first fruits) to Yerushalayim when they were oleh regel. The pilgrim would read, in thanks, the parsha of "Arami Ovaid Avi." The Geonim asked: Why was this text chosen to be the focus of the seder? There are so many direct and explicit parshiyos in Sefer Shemos that directly discuss yetzias Mitzrayim, the exodus. Why choose a more indirect parsha to serve as the primary text for exposition on the first night of Pesach?


Concentric-ring phased arrays subdivided into sectors (radial slices) can, with appropriate phasing, produce power absorption patterns useful for hyperthermia cancer therapy. The ability of a concentric-ring array to move a focal region along the central axis of the transducer is well known. Less well known is the ability of such an array to produce variable diameter annular (or ring) focal regions. Such focal rings can be effective in heating some tumors if directed around the tumor periphery. These focal rings have been produced in the past by fixed annular focus lenses, or effectively by mechanical scanning of "point" focus ultrasonic transducers. Production of these focal rings by a concentric-ring phased array has the advantage of allowing the focal ring diameter and focal length to be easily changed and scanned by phasing providing much greater heating flexibility. However, under some conditions such arrays produce very large secondary focus effects along the central axis of the amay. Concentric-ring arrays can also provide only patterns of circular symmetry. These problems can be partially solved by dividing the disk of the array into sectors. By appropriate phasing of the sectors, the intensity along the central axis can be greatly reduced. Moreover, appropriate phasing of the rings and sectors can produce patterns that are circularly asymmetric. By controlling these asymmetries, nonspherical tumors can be heated more optimally. Power absorption patterns in Iossy media for this class of applicators are analyzed numerically allowing a quantitative evaluation of both advantages and limitations of this approach. A thermal model based on the bioheat equation is also used to predict temperature distributions in volumes where important thermal parameters, particularly blood flow, are varied.


The enhanced conduction at low fields (<4MV∕cm) in metal-insulator semiconductor structures having nitrided oxides was recently explained using a generalized thermionic trap-assisted tunneling model. In the present work, we show that the same model can predict both high and low field leakage currents if we assume that a fraction (∼35%) of the insulator thickness located next to the metal-insulator junction is devoid of traps.


Cubanite occurs as small veinlets in chalcopyrite and as anhedral aggregates of small grains. Individual grains or aggregates are not common. Pyrargyrite occurs as unoriented grains in chalcopyrite. Cubanite was reported from liq. magmatic, pegmatitic, pneumatolytic, and hydrothermal veins. The presence of Cubanite in the S ores shows that the complex ore deposition is formed by hydrothermal process at temps. >250°. Pyrargyrite is an earlier mineral formed through the hydrothermal process.


Phenylketonuria (PKU) is considered to be a paradigm for a monogenic metabolic disorder but was never thought to be a primary application for human gene therapy due to established alternative treatment. However, somewhat unanticipated improvement in neuropsychiatric outcome upon long-term treatment of adults with PKU with enzyme substitution therapy might slowly change this assumption. In parallel, PKU was for a long time considered to be an excellent test system for experimental gene therapy of a Mendelian autosomal recessive defect of the liver due to an outstanding mouse model and the easy to analyze and well-defined therapeutic end-point, i.e. blood L-phenylalanine (L-Phe) concentration. Life-long treatment by targeting the mouse liver (or skeletal muscle) was achieved using different approaches, including (i) rAAV or non-viral naked DNA-vector based gene addition, (ii) genome editing using base editors delivered by rAAV vectors, and (iii) by delivering rAAVs for promoter-less insertion of the PAH-cDNA into the Pah locus. Here we summarize the gene therapeutic attempts of correcting a mouse model for PKU and discuss the future implications for human gene therapy.


The folk-custom tourism is the characteristics and advantages of tourism resources in Big Xiangxi.In the course of developing folk-custom tourism in Big Xiangxi,we must set the goal of achieving sustainable development and preserve the balance of cultural ecology, so that we can protect and pass down the folk-custom and further develop tourism .we must persist in the principles of preserving the unique of folk-custom culture and participation of residents,and choose the optimized models such as setting up the Primitive Ecological Nationality Village,etc.and establish corresponding ensuring system.


Mobile Health or mHealth is an emerging concept of the use of mobile devices and wireless technology for healthcare purposes. Recently, mHealth-related technology is expected to form a new category of medical devices particularly in the monitoring of patients. This is also anticipated to improve the efficiency and effectiveness of pharmaceutical clinical trials. However, there are challenges to utilize this enabling technology to innovate healthcare business. Considering this context, we explore the potential of mHealth. First, we position mHealth with respect to current innovation theories based on intensive literature review. Second, we hypothesize that mHealth has two potential areas of innovation: product innovation in the medical devices industry and process innovation in the pharmaceutical industry. To test the hypotheses, we conducted a holistic observation on clinical trials to examine how large mHealth impacts a treatment pathway by innovative products. Consequently, we observed 193 studies are registered; however, most of these remain at a primitive level of information and communication technology such as text messaging and application, which suggests a significant gap to the market forecasts. This present study forms the basis of the trend of mHealth and a future outlook from the viewpoint of technology and innovation management.


The overall objective of this project was to use a systems biology approach to evaluate the potentials of a number of cyanobacterial strains for photobiological production of advanced biofuels and/or their chemical precursors. Cyanobacteria are oxygen evolving photosynthetic prokaryotes. Among them, certain unicellular species such as Cyanothece can also fix N2, a process that is exquisitely sensitive to oxygen. To accommodate such incompatible processes in a single cell, Cyanothece produces oxygen during the day, and creates an O2-limited intracellular environment during the night to perform O2-sensitive processes such as N2-fixation. Thus, Cyanothece cells are natural bioreactors for the storage of captured solar energy with subsequent utilization at a different time during a diurnal cycle. Our studies include the identification of a novel, fast-growing, mixotrophic, transformable cyanobacterium. This strain has been sequenced and will be made available to the community. In addition, we have developed genome-scale models for a family of cyanobacteria to assess their metabolic repertoire. Furthermore, we developed a method for rapid construction of metabolic models using multiple annotation sources and a metabolic model of a related organism. This method will allow rapid annotation and screening of potential phenotypes based on the newly available genome sequences of many organisms.


Many applications require a DC bus supporting connections to several renewable energy sources, storage systems and loads. However, due to the intermittent nature of renewable energy sources and load variations it is essential to stabilize the voltage of the DC bus. Usually a battery is used to support the DC bus voltage, but their continuous charge and discharge cycling will affect his lifetime. Thus, the use of a storage system based in supercapacitors provides an interesting alternative to stabilize the DC power grid. In this context, this work presents a study of a storage system based in supercapacitors combined with a bidirectional quadratic DC-DC converter to support the DC bus. A full design of the controllers for the quadratic converter is also presented. The behaviour of the system will be tested through several simulation results.


In practice,there are lots of factors which affect the stability of the slope.Slope stability of the fuzzy comprehensive evaluation model was built with fuzzy mathematics theory.The index system and the calculation of the weight factor were discussed;Based on this model,the stability of landslide in Tongchuan Chauncey of Shaanxi Province was evaluated,making the evaluation of slope stability from the traditional single factors,qualitative description and semi-quantitative analysis into qualitative and quantitative evaluation process.This makes the whole into a quantitative calculation and analysis.The assessment results becoming more scientific and rational,and more objective reflection of reality.


Recent years have seen a growing interest in an area of research commonly referred to as sensory deprivation (S-D). In these studies, 1-3,10 persons are exposed to an environment altered in terms of the available stimulation. Subjects in most of these studies have been normal volunteers, and a common finding is that S-D produces some degree of disruption in behavior. Occasionally normal subjects report dramatic behavioral changes during S-D, with symptoms approximating pathological reactions such as hallucinations, delusions, and disorientation. In a few studies subjects already experiencing behavior pathology, eg, hospitalized psychiatric patients, have been subjected to a S-D situation. For example, Azima and Cramer, 1 Gibby et al, 5 and Harris 6 placed schizophrenics and other types of psychiatric patients in S-D environments with the paradoxical finding that improvement in behavior occurred rather than a deepening of the pathology. However, only in the experiment


Learning from Hallucination (LfH) is a recent machine learning paradigm for autonomous navigation, which uses training data collected in completely safe environments and adds numerous imaginary obstacles to make the environment densely constrained, to learn navigation planners that produce feasible navigation even in highly constrained (more dangerous) spaces. However, LfH requires hallucinating the robot perception during deployment to match with the hallucinated training data, which creates a need for sometimes-infeasible prior knowledge and tends to generate very conservative planning. In this work, we propose a new LfH paradigm that does not require runtime hallucination—a feature we call "sober deployment"—and can therefore adapt to more realistic navigation scenarios. This novel Hallucinated Learning and Sober Deployment (HLSD) paradigm is tested in a benchmark testbed of 300 simulated navigation environments with a wide range of difficulty levels, and in the real-world. In most cases, HLSD outperforms both the original LfH method and a classical navigation planner.


Transforming growth factor–β (TGF-β) signaling regulates various aspects of cell growth and differentiation and is often dysregulated in human cancers. We combined genetic engineering of a human organotypic three-dimensional (3D) skin model with global quantitative proteomics and phosphoproteomics to dissect the importance of essential components of the TGF-β signaling pathway, including the ligands TGF-β1, TGF-β2, and TGF-β3, the receptor TGF-βRII, and the intracellular effector SMAD4. Consistent with the antiproliferative effects of TGF-β signaling, the loss of TGF-β1 or SMAD4 promoted cell cycling and delayed epidermal differentiation. The loss of TGF-βRII, which abrogates both SMAD4-dependent and SMAD4-independent downstream signaling, more strongly affected cell proliferation and differentiation than did loss of SMAD4, and it induced invasive growth. TGF-βRII knockout reduced cell-matrix interactions, and the production of matrix proteins increased the production of cancer-associated cell-cell adhesion proteins and proinflammatory mediators and increased mitogen-activated protein kinase (MAPK) signaling. Inhibiting the activation of the ERK and p38 MAPK pathways blocked the development of the invasive phenotype upon the loss of TGF-βRII. This study provides a framework for exploring TGF-β signaling pathways in human epithelial tissue homeostasis and transformation using genetic engineering, 3D tissue models, and high-throughput quantitative proteomics and phosphoproteomics. Description A human skin model reveals requirements for distinct TGF-β signaling pathways in epidermal development and homeostasis. Modeling TGF-β signaling in human skin Studies in mice and human tumors have identified multiple roles for TGF-β signaling in normal skin biology and in the development and progression of skin cancers. To investigate the requirements for TGF-β signaling in human epidermal development and homeostasis, Ye et al. performed phenotypic and quantitative proteomic and phosphoproteomic analyses of an in vitro model of stratified human epidermis with knockout of individual TGF-β signaling components. Whereas SMAD4-dependent signaling was important for limiting epidermal proliferation and promoting differentiation and cell adhesion, SMAD4-independent signaling was important for preventing invasive growth by suppressing signaling through MAPK pathways. The proteomic and phosphoproteomic data will enable future studies investigating TGF-β signaling in normal and pathological contexts, and the human epidermis model could be exploited for future drug discovery efforts.


This paper introduces the dual-level traffic smoothing technique for hard real-time communication over multi-hop switched Ethernet without any modifications to existing Ethernet hardware. The dual-level traffic smoothing technique combines the node-level traffic smoothing with the global-level traffic controlling techniques. Thorough measurements are made to demonstrate the hard real-time communication performance of this approach over multi-hop switched Ethernet.


he illustrates how Coleridge was not only influenced by a range of a diverse number of figures, but he also creatively modified their thought. Among the many figures considered are Heraclitus, Plato, Plotinus, Bacon, Böhme, Kant, and Schelling. Adding to this this, Cheyne also draws helpful comparisons to the thought of Hegel, Newman, Kierkegaard, Sartre, and Heidegger, among others, bringing Coleridge into an even wider dialogue. Though Cheyne is not the first to claim for Coleridge a greater place in intellectual history, he comes closer to entering that "class of thinkers" described by Mill than many of those who have come before him. Alexander J. B. Hampton University of Toronto


The case describes decisions faced by Rob Loomis and Jon Pruden, the cofounders of a coffeehouse, and how they resolved them. First, their coffeehouse franchise experienced disappointing results—they decided to close it and reopen as an independent coffeehouse. Shortly thereafter, they had to respond to an existential challenge to their business—the entry of Starbucks across the street. The case describes Rob's decision to persist despite Starbucks' entry, and his strategic, operational, and tactical moves to ensure growth. A key dilemma that Rob faced was whether his initial success against Starbucks was sustainable. An underlying theme of the case is that entrepreneurial success requires persistent improvisation to adapt to dynamic and uncertain environments.


The Physiological Profile Assessment (PPA) is a validated composite measure of sensorimotor function, known to predict falls with 75% accuracy. This work aimed to investigate whether PPA is also associated with fragility fractures.

 Participants were 489 community-dwelling older people (age=70-90) enrolled in the longitudinal population-based Sydney Memory and Ageing Study. Participants underwent comprehensive assessments at enrolment, including the 5-item PPA (visual contrast sensitivity, lower limb proprioception, knee extension strength, simple reaction time and postural sway). Participant records were linked to emergency department, hospital and death records (2005-2014) to identify fragility fractures following baseline assessment, with median follow-up duration of 7.5 years. Negative binomial regression, with observation time as the offset, was used to assess factors associated with fractures.

 At baseline assessment, 281 (57.5%) participants were assessed as having low/mild fall risk [PPA<1] and 208 (42.5%) as moderate/marked/very marked fall risk [PPA score >1]. Over the study period, 72 (14.7%) individuals sustained 1 fracture, and a further 39 (8.0%) sustained 2 or more fractures.
 Univariate analysis showed that increasing age (Incidence Rate Ratio (IRR) 1.1, 95%CI 1.0-1.1, p=0.0026), being female (IRR 1.8, 95%CI 1.3-2.8, p=0.0033), having osteoporosis (IRR 1.7, 95%CI 1.1-2.6, p=0.0340) and moderate/marked/very marked PPA (IRR 1.8, 95%CI 1.2-2.7, p=0.0025) were associated with fractures. In the multivariate analysis, only moderate/marked/very marked PPA (IRR 1.6, 95%CI 1.1-2.5, p=0.0159) and being female (IRR 1.8, 95%CI 1.1-2.8, p=0.0121) remained independently associated with fractures.

 These findings show that people at increased risk of falls based on the Physiological Profile Assessment are also at increased risk of future fragility fractures regardless of the presence of osteoporosis. Early identification of this high risk population provides the opportunity to intervene with evidence based strategies to minimize falls risk as well as considering pharmacological management of bone health.


According to Government Accounting Standards (GAS) in Indonesia, the government recognizes the fixed assets if there is evidence that there has been a title transfer and/or legal control. Accounting for fixed assets has been regulated in Government Accounting Standard - Statement No. 07. Reliability of land reported in financial statement is a must, due to administrative regulation and anticipation of legal risk. This research paper aims to determine the implementation of GAS Statement No. 07: Accounting for Fixed Assets in Provincial Government of West Kalimantan, particularly the reliability of the recognition of land assets, and efforts made by Financial and Assets Management Board (BPKAD) of West Kalimantan on its responsibility of assets administration, especially in order to improve the reliability of the recognition of land assets. The result showed 98.78% of the total land assets reported on Balance Sheet of the Provincial Government of West Kalimantan as December 31, 2015 had certificate on behalf of the Provincial Government of West Kalimantan, the indication of high reliability. Keywords: PSAP No. 07, Accounting for fixed assets


Objectives/Scope: Monitoring is an essential component of risk management for geologic carbon sequestration. The high cost of conducting monitoring operations often requires evaluating the potential value of data before the actual measurement are collected. The value of information (VOI) of the data is defined here as the uncertainty reduction in the objective of interest (e.g., cumulative CO2 leakage in this study) that will be obtained once the data are assimilated into model(s). In this study, we will introduce a novel approach to quantify the expected uncertainty reduction or VOI before the monitoring data are acquired, such that the optimal monitoring operation can be determined. After the application of optimized monitoring strategy, new monitoring data are usually available from the CO2 storage site. The collected monitoring data can then be incorporated into the models to reduce the uncertainty of CO2 and brine leakage through wellbores. This study focuses on the development of statistical methods to improve the precision of risk assessments by quantifying the uncertainty reduction in CO2 sequestration before and after acquiring monitoring data. Methods, Procedures, Process: A filtering-based data assimilation procedure is used to perform the monitoring design. To reduce the computational cost of the filtering-based data assimilation process, a supervised machine learning algorithm, multivariate adaptive regression splines (MARS), is applied to develop the computationally efficient reduced order models (ROMs) from full numerical simulations of CO2 and brine flow. It is important to point out that the monitoring time is included as one uncertain parameter to build the ROMs, such that we can predict the measurement at any time during the monitoring lifetime. All the training simulations used to build ROMs are performed by the use of the finite element heat and mass transfer (FEHM) simulator. The expected uncertainty reduction in cumulative CO2 leakage for all the potential monitoring scenarios can be quantified, and the optimal monitoring strategy is chosen to be the one that gives the highest amount of uncertainty reduction, and therefore the most precise estimate of risk. After the monitoring data come in, the uncertainty reduction in CO2 and brine leakage rate through wellbores can be quantified by applying the Affine Invariant Markov chain Monte Carlo (MCMC) algorithm. The rate of CO2 and brine leakage through wellbore can be evaluated by using Integrated Assessment Model (IAM) that couples storage-reservoir model and wellbore model. Generally, MCMC can be prohibitively expensive because each evaluation of proposed state in Markov chain requires a forward simulation, and MCMC often takes hundreds of thousands of runs to converge for a large scale model. To alleviate the high computational cost, ROMs or analytical solutions are developed to evaluate the acceptance of a proposed state in Markov chain. Further, the posterior distribution of model parameters generated from MCMC sampling can be used to predict the longterm fate of CO2 with confidence.


When interviewed about requirements pertaining to new hires, an executive in the Human Resources Division of Men's Wearhouse responded, "We don't look for people with specific levels of education and experience. We look for one criterion for hiring: optimism. We look for passion, excitement, energy. We want people who enjoy life." Students who are being trained in today's business curriculum are constantly inundated with highly complex subjects such as analytics, finance, and subject related theory. Rarely are they introduced and/or trained in ways to maximize their potential for success regarding their professional outlook once entering the workplace. This paper discusses an approach to include positivity via Positive Psychology, studying "what makes life most worth living" as an enhancement to an undergraduate business curriculum focusing on 1) communication best practices, 2) building professional relationships, and 3) management techniques. Included in this research are professional development techniques that can be easily replicated by educators and/or practitioners.


Background It is uncertain whether lower levels of staffing by nurses at hospitals are associated with an increased risk that patients will have complications or die. Methods We used administrative data from 1997 for 799 hospitals in 11 states (covering 5,075,969 discharges of medical patients and 1,104,659 discharges of surgical patients) to examine the relation between the amount of care provided by nurses at the hospital and patients' outcomes. We conducted regression analyses in which we controlled for patients' risk of adverse outcomes, differences in the nursing care needed for each hospital's patients, and other variables. Results The mean number of hours of nursing care per patient-day was 11.4, of which 7.8 hours were provided by registered nurses, 1.2 hours by licensed practical nurses, and 2.4 hours by nurses' aides. Among medical patients, a higher proportion of hours of care per day provided by registered nurses and a greater absolute number of hours of care per day provided by registered nur...


Gradient polymer blend material recently received much concern, because of its advantages, such as good combination properties and simple preparation. The research progress of gradient polymer blend material in the past decade is summarized in this paper. Methods of preparing gradient polymer blend material respectively in solution, melting and latex blend systems are introduced in detail, such as dissolution-diffusion method, electric induction method, temperature gradient method. Related theories of predicting how the dispersed phase or polymer compositions form gradient morphology in different blend systems are introduced, and the influencing factors of forming gradient structure are discussed. The development trend and main research topics of gradient polymer blend material in the future are also suggested.


The separation of hydrogen from synthesis gas is a major cost element in the manufacture of hydrogen from coal. Separation of these gases by membranes is an alternative technique that is still largely unexplored and that could offer substantial cost savings. The authors have been developing membranes for this application at Membrane Technology and Research, Inc. After reviewing polymer permeability data available in the literature or obtained at MTR, two polymers were selected for membrane development work: (1) Poly(etherimide) for the separation of hydrogen from nitrogen and from carbon monoxide; and (2) Poly(ether-ester-amide) for the separation of hydrogen sulfide and carbon dioxide from hydrogen. After characterizing the membrane properties of relatively thick (20-50 {mu}m) films, the authors concentrated on fabricating asymmetric and composite ultrathin high-performance membranes. Asymmetric or composite ultrathin membranes in which the permselective layer is on the order of 0.5- to 1.0 {mu}m-thick are required if usefully high membrane fluxes are to be obtained. The membranes were then tested with pure gases and gas mixtures. Results on both types are briefly discussed.


The quality of a software product is determined by its usability; the quality of technical documentation is determined by its comprehensibility. Usability conceptualizes the person using a software product to perform a task; comprehensibility deals with the reader of operating instructions-although they are generally one and the same person. However, only rarely are the software and technical documentation part of an integrated design. This is all the more surprising in that, on the technical level, the boundary between software and user information is becoming increasingly blurred; one need only think of the hypertext links between software and help systems, or of electronic versions of operating instructions. We make the case for considering user, software, and operating instructions as a single system oriented toward performing a task; the operating instructions therefore are regarded as a subsidiary subsystem of a structure to be described. This is done from a linguistic perspective, with reference to the central category of knowledge available to the user or contained in the software and in the operating instructions and that we approach via an empirical analysis of authentic material (operating instructions as primary data, statements of end users concerning operating instructions). Taking the example of creating software and operating instructions for a computer tomograph, we show how the relevant knowledge elements contribute to the accomplishment of an operating task and discuss the resultant requirements concerning the contents of software and operating instructions, particularly for handling fault and problem situations.


Abstract The homogeneous ThO2-UO2 fuel cycle option for a pressurized water reactor (PWR) of current technology is investigated. The fuel cycle assessment was carried out by calculating the main performance parameters: natural uranium and separative work requirements, fuel cycle cost, and proliferation potential of the spent fuel. These performance parameters were compared with a corresponding slightly enriched (all-U) fuel cycle applied to a PWR of current technology. The main conclusion derived from this comparison is that fuel cycle requirements and fuel cycle cost for the mixed Th/U fuel are higher in comparison with those of the all-U fuel. A comparison and analysis of the quantity and isotopic composition of discharged Pu indicate that the Th/U fuel cycle provides only a moderate improvement of the proliferation resistance. Thus, the overall conclusion of the investigation is that there is no economic justification to introduce Th into a light water reactor fuel cycle as a homogeneous ThO2-UO2 mixture.


Mi-Ae Jang, Sang-Yong Shin, Seungman Park, Moon-Woo Seong, Sung Sup Park, and SunHee Kim, as Diagnostic Genetics Subcommittee, The Korean Association of Quality Assurance for Clinical Laboratory Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine; Green Cross Laboratories Quality control for genetic tests has become more important as the test volume and clinical demands increase dramatically. The diagnostic genetics subcommittee of the Korean Association of Quality Assurance for Clinical Laboratories performed two trials for cytogenetics and molecular genetics surveys in 2013. A total of 43 laboratories participated in the cytogenetic surveys, 30 laboratories participated in the fluorescent in situ hybridization surveys, and 122 laboratories participated in the molecular genetics surveys in 2013. Almost all of them showed acceptable results. However, some laboratories had unacceptable results for karyotype nomenclature, detection of complex cytogenetic abnormalities in hematologic neoplasms and constitutional anomalies. The molecular genetics surveys included various tests: Mycobacterium tuberculosis detection, hepatitis B and C virus detection and quantification, human papilloma virus genotyping, gene rearrangement tests for leukaemia and lymphomas, gene tic tests for JAK2, fms-related tyrosine kinase 3, Nucle ophosmin, cancer-associated genes (KRAS, EGFR and BRAF), hereditary breast and ovarian cancer genes (BRCA1 and BRCA2), Li-Fraumeni syndrome (TP53), Wilson disease (ATP7B), achondroplasia (FGFR3), Huntington disease, spinocerebellar ataxia, spinal and bulbar muscular atrophy, mitochondrial encephalopathy with lactic acidosis and stroke like episodes, myoclonic epilepsy associated with ragged-red fibers, Prader-Willi/ Angelman syndrome, Duchenne muscular dystrophy, spinal muscular atrophy, Fragile X syndrome, non-syndromic hearing loss and deafness (GJB2), apolipoprotein E genotyping, methylenetetrahydrofolate reductase genotyping, ABO genotyping and DNA sequence analysis. Molecular genetic surveys showed excellent results for most of the participants. The external quality assessment program for genetic analysis in 2013 was proved to be helpful for continuous education and evaluation of quality improvement. (J Lab Med Qual Assur 2014;36:71-83)


The XPS image is obtained by the dissection of the surface area of interest into a series of adjacent narrow strips. The width of the entrance slit system of the energy analyzer gives the strip width and a translational movement of the specimen makes it possible to investigate the total number of strips step by step. By means of the double focusing properties of the spherical analyzer the energy spectrum from each point (spot) of the strip area under observation is available on the detector focal plane. Specific photoelectron lines are selected by a suitable choice of the sphere voltages. A position sensitive electron detector together with a computer is used to collect and store these spectra simultaneously in the course of one measurement. The net count rate is evaluated afterwards. Each spot of the strip is represented by its corresponding value of the net count rate and the series of values is stored in a computer memory. At the end of collection of all the strip information the image is put together strip by strip. To date a resolution of 0.3 mm has been realised and the time of data collection for an area of 10 × 10 mm2 is about one hour. The corresponding time of measurement with our imaging method is just a few minutes as one needs only the elemental distribution of an element along a single line as in an electron micronalyzer with a line scan.


Six species of new records collected from intertidal mangrove/non-mangrove and subtidal cave sediments during a mangrove ecological study (1998-2001) and a marine cave expedition (2002) in Hong Kong waters are redescribed. These include two enoplids: Anoplostoma viviparum in Anoplostomatidae and Trissonchulus janetae in Ironidae, two chromadorids:Paracomesoma dubium and Actarjania splendens in Comesomatidae, and two monhysterids: Parodontophora marina and Parodontophora c.f. danker in Axonolaimidae. Five of them are the first records from China. Ecological and taxonomic remarks are provided and discussed in comparison with the original descriptions.


1. Introduction .—The first part of this paper, written by Love, contains a theoretical solution of the problem of rational hydrodynamics which has been named by writers on ballistics, "Lagrange's problem"; the second part, written by Pidduck, gives the application to ballistics. In the problem it is supposed that a given mass of gas, which is initially in a uniform state, is contained in a segment of a tube of uniform section. At one end the segment of the tube is bounded by a fixed transverse section, and at the other end the tube is closed by a piston of given mass, which is initially at rest and is free to move along the tube without resistance. It is required to find the subsequent states of the gas and the motion of the piston.


The Tg-HbIIA cDNA was cloned and then the bioinformatics, expression and immune defense analysis of Tg-HbIIA cDNA were carried out. The full length of Tg-HbIIA cDNA was 731bp, which consists of an open reading frame of 450bp encoding a polypeptide of 150 amino acids, a 5'-UTR of 63bp and a 3'-UTR of 246bp; the deduced amino acid sequence of Tg-HbIIA shared 89% and 88% similarity with HbIIA from two species of the genus Scapharca respectively. The structure prediction of Tg-HbIIA showed the hemoglobin domain and the ten potential heme binding sites. The mRNA expression of Tg-HbIIA in haemocytes was detected highest in all the clam cells/tissues including haemocytes, adductor muscle, foot, hepatopancreas, gill and mantle. The Quantitative Real-time PCR showed that the mRNA transcript level of Tg-HbIIA, significantly up-regulated after Vibrio parahaemolyticus, Lipopolysaccharide and Peptidoglycan challenge which indicated that Tg-HbIIA was involved in the immune defense responses against bacterial infection and exposure to bacterial pathogenic factors. However, the temporal and level of expression were different in three challenge groups.


: Addition of tetrahydrothiophene (THT) to a THF solu-tion of bis(iodozincio)methane modified the stability and reactivity: EXAFS analysis indicated that THT stabilizes bis(iodozincio)methane in a monomeric structure; the species reacts with acyl chlorides to give 1,3-diketones.


WHEREAS, in accordance with Ark. Code Ann. § 14-54-901, the City of Conway has corrected conditions existing on 2902 Pheasant Drive within the City of Conway and is entitled to compensation pursuant to Ark. Code § 14-54-904: and WHEREAS, State law also provides for a lien against the subject property, with the amount of lien to be determined by the City Council at a hearing held after the notice to the owner thereof by certified mail with said amount $233.48 ($184.99 + Penalty-$18.49 + filing fee-$30.00) to be thereafter certified to the Faulkner County Tax Collector; and WHEREAS, a hearing for the purpose of determine such lien has been set for October 8 th , 2013 in order to allow for service of the attached notice of same upon the listed property owners, by certified or publication as is necessary.


This paper develops a distributed state estimation approach for smart grids. Particularly, the designed filter is developed in an interconnected way where the packet dropouts take place between estimators. The error function between true and estimated states is written in compact form, then it can be transformed into the linear matrix inequality (LMI). After solving the LMI problem, the desired gains are determined for the smart grid state estimation. The proposed method is applied to the IEEE 14-bus system where system state and input matrices are obtained from the Holt-Winters approach.


Females have an efficient searching capacity. Females, in general, use their antennae to examine an aphid host in order to assess size and determine if the aphid has already been parasitized. Females lay eggs into aphids by means of rapid movement of the abdomen. A female will curl her abdomen under her body and then "poke" the aphid using her ovipositor (egg-laying device) to insert an egg. Eggs hatch into larvae that consume the internal contents of aphids. The parasitized or "mummified" aphids are goldenyellow to brown in color. A. ervi can parasitize many aphids in a day.


This project has been completed. The data have been fully analyzed and published. Publications that evolved from this program, either directly or indirectly, are listed.


Asymmetric information and risk are two main problems in credit markets. These problems are even

higher in developing credit markets. Formal financial sectors in developing countries are still growing

and are reluctant to provide credit to poor. Micro credit is considered as an effective strategy to

overcome this problem and to give poor opportunities to access financial services. Therefore there is a

strong need for continuous operation of micro- credit programs. However, many micro credit programs

face difficulties in achieving main goals of sustainability and outreach. This study aimed at assessing

these two main aspects of success of micro credit programs. A comparison was done between two

micro credit programs: SEEDS, Sarvodaya Economic Enterprise Development Services Ltd, and Gami

Pubuduwa, a program operated by Hatton National Bank in Sri Lanka. The results showed the program

operated by the private commercial bank was achieving success faster than the program by community

based organization in relation to sustainability indicator, but SEEDS was in ahead in reference to

outreach measures. Findings evidenced the importance of profit orientation and targeting

"economically active poor" for the success of micro credit programs. The study was based on primary

and secondary data collected during two weeks period of field work activities in Sri Lanka.


Environmentalism began to take shape in the second half of the 20th century, and in its' more radical form in the 1990's. The proposed study tries to examine the various academic conceptual developments in the field of ecocriticism. It depicts the interdisciplinary relationship between literature and environment in varied forms. The research work also attempts to find out that separation of humanity from nature has a long history, and more precisely it has roots in Christian and post-Christian Western culture. It explores that how the study of the rise of industrial capitalism, which first appeared in Western Europe and spread by colonialism be relevant to this field. The work also portrays that, how with the advent of modernity, the society is heading towards more and more westernised form of culture and ideology. It examines how individualism emerged as a major phenomenon, and the sole importance shifted to man because of his rational thinking. The work will trace the urgent need to set up a kind of value system and ideology in this society so that those existing views of domination can be proved false and anthropocentric view can be shifted to biocentric and ecocentric. The work also attempts to give local colour to the research by providing an ecological glimpse in the literary texts of few Indian English female writers.


Naive painting was settled into our language from "naive" which is a french word. Besides having the meaning "Pure and unaffected",it is also used for uneducated artists and their works. It is not any theoritical framework. It often defines a childish description. It is based on individual instincts and intuitions. Naive art starting in 19th century and expanding in 20th century gathered movement and speed in 1950s. With the emergence of naive art as a species or a movement,art market has gained momentum in this direction. Inclining on naive art is prominently seen especially in 20th century French art. Tendencies and efforts of seeking childlike purity of the artists like Picasso and Gauguin are the most significant samples of this and besides,the most important representative of naive painting is Henri Rousseau. Some of the representatives of naive painting in Turkey are Fahir Aksoy, Ibrahim Balaban, Mehmet Pesen, Hikmet Karabucak and Oya Katoglu. Today there are representatives of naive painting in our country, they take place in art environments through holding their group exhibitions and exhibiting their works for the art audience and one of the artists is Naive Artist Recai Demirsoz from Safranbolu. The art life and works of Naive artist Recai Demirsoz forming the nature of the study have been included in the essay.


Maros Regency is an area that has potential coastal resources. The social interaction of fishing communities in the coastal regions of Maros Regency is relatively high in the effort to utilize fishery resources. This is marked by the various fishing gear used by fishers, so the phenomenon of fisherman conflict becomes a social process that also colours the social interactions of these fishing groups. Differences in resource utilization and management methods can trigger social conflicts between fishers involving other stakeholder components. This study aims to analyze the types and forms of conflicts in the use of coastal resources that occur in the coastal areas of Maros Regency, South Sulawesi Province. The methods used are observation, interviews and Focus Group Discussion (FGD) with qualitative data analysis to describe the types and forms of conflicts in the use of coastal resources, and quantitatively with spatial analysis methods using Geographic Information System (GIS) applications to analyze conflict locations. The results showed that the types of fishing conflicts in the Maros Regency's coastal areas were agrarian conflicts, class conflicts, technological conflicts, and conflicts of perception. The forms of conflict in the use of natural resources (including fishery resources) are horizontal conflicts (traditional fishers and klitik net fishermen) with semi-modern fishermen (cantrang fishermen) and vertical conflicts (semi-modern fishermen and cantrang fishers) with the government ( Maros District Fisheries Service, Camat and Village Heads, both open (manifest) and closed (latent).


The curing kinetics of PF resin modified with sodium silicate had been investigated by differential scanning calorimetry (DSC). The kinetic analysis was performed at heating rates of 5, 10, 15, and 20°C/min,respectively. The kinetic parameters such as reaction order and activation energy were solved by Kissinger and Crane equation. The relationship between curing temperature and heating rate was also investigated. The activation energy and the curing reaction order,which were obtained by kinetic calculation, are 83.00kJ/mol and 0.917, respectively. The curing reaction kinetics equations were built by the obtained best curing temperature, reaction order, pre-exponential factor and reaction rate constant.


reviewer has nowhere seen a finer exposition of the distinction between the Christian conscience and the psychoanalytic super-ego, and of the need for both in order to have an adequate understanding of the human individual. The section on identification, as the psychological mechanism whereby good example is made effective, is an illuminating one, and one fraught with significant implications for Christian education. Equally valuable for the priest is the discussion of what the author calls the "neurosis of unbe lief," namely, the manner in which lack of faith and loss of faith may some times be a manifestation of neurosis. To the present reviewer, Stern proves his primary thesis, on the compatability of the psychoanalytic method with Christian principles, much more adequately than he does his second, on the third revolution. Under standably, Karl Stern, who is a psychiatrist, is more at home discussing psychoanalysis than he is treating psychology. He maintains that the for mer can be salvaged from the psychological revolution, but implicitly con signs the major portion of psychology to unalterable opposition to Catholic principles. It seems that preoccupation with the development of a thesis has led the author into an inconsistent position on this point. It is difficult to see why one cannot do for psychology in general what Stern attempts to do for psychoanalysis, and why it is not as important and as urgent to do so. Some minor blemishes strike the reader. Sometimes, as on page 235, scriptural quotations are identified by chapter and verse; elsewhere, as on the very next page, they are not. Speaking of the love of one's neighbor for the sake of God, Stern goes on to remark that this process need not be con scious (p. 239). However, if it were not conscious, could it be considered a virtuous act, as Stern clearly intends that it should? In another place he writes: "Again we have entered a strange layer of the psychic, a realm in which freedom is not the same as in deliberate planning and yet is not ex cluded as in a machine" (p. 216). One wonders, how valid and how helpful is such a concept? These, however, are admittedly minor points in a book of unquestioned significance. The dominant impression of the book is that psychoanalysis is essentially a method, a technique for treating mental disorder. Like all techniques, it is in itself indifferent, as the book convincingly demonstrates. In the hands of a Christian, it can become a truly Christian technique. Perhaps our tragedy up to the present is that there have been too few Christian psychoanalysts.


Students' cognitive engagement in teaching and learning process is an important factor for successful learning. Improvement of students'cognitive engagement was investigated through a teaching and learning process using POE (predict-observe-explain) approach and self-developed interactive media. The objective of this study is to improve students' cognitive engagement in teaching and learning process at junior high school. The development of interactive multimedia uses Animate CC and Four D and its validation were explained. The self-developed interactive multimedia was used with POE approachin teaching and learning process at junior high school. This three steps predict-observe-explain approach is used and students higher order thinking and total participants showing higher order thinking characteritics were analysed. It was found that the self-developed interactive multimedia isto contribute to the students' active cognitive engagement.


Abstract This study assesses the impact of two different remote sensing–derived leaf area index (RSLAI) datasets retrieved from the same source (i.e., Advanced Very High Resolution Radiometer measurements) on a general circulation model's (GCM) seasonal climate simulations as well as the mechanisms that lead to the improvement in simulations over several regions. Based on the analysis of these two RSLAI datasets for 17 yr from 1982 to 1998, their spatial distribution patterns and characteristics are discussed. Despite some disagreements in the RSLAI magnitudes and the temporal variability between these two datasets over some areas, their effects on the simulation of near-surface climate and the regions with significant impact are generally similar to each other. Major disagreements in the simulated climate appear in a few limited regions. The GCM experiment using the RSLAI and other satellite-derived land surface products showed substantial improvements in the near-surface climate in the East Asian and We...


Buses are central building blocks in the architecture of digital systems. There are numerous standards for bus architectures and evaluation metrics in terms of data transfer rate, quality of service, and latency; however, it is not common to find metrics related to the physical features of bus implementations, such as power consumption and area in terms of their microarchitecture. This paper evaluate bus micro-architectures at pre-synthesis level, allowing for the comparison of alternative circuits implementing the same standard and thus providing estimations on the power consumption and area requirements. A metric is proposed to evaluate the bus implementation and its utilization is shown with generic serial and parallel buses, based on simulations with a 0.18µm CMOS standard cell library.


The termination of protein synthesis in bacteria requires two codon-specific release factors, RF-1 and RF-2. A gene for a third factor, RF-3, that stimulates the RF-1 and RF-2 activities has been isolated from the gram-negative bacteria Escherichia coli and Dichelobacter nodosus. In this work, we isolated the RF-3 gene from Salmonella typhimurium and compared the three encoded RF-3 proteins by immunoblotting and intergeneric complementation and suppression. A murine polyclonal antibody against E. coli RF-3 reacted with both S. typhimurium and D. nodosus RF-3 proteins. The heterologous RF-3 genes complemented a null RF-3 mutation of E. coli regardless of having different sequence identities at the protein level. Additionally, multicopy expression of either of these RF-3 genes suppressed temperature-sensitive RF-2 mutations of E. coli and S. typhimurium by restoring adequate peptide chain release. These findings strongly suggest that the RF-3 proteins of these gram-negative bacteria share common structural and functional domains necessary for RF-3 activity and support the notion that RF-3 interacts functionally and/or physically with RF-2 during translation termination.


In this article, Dr Ianchulev discusses MIGS supraciliary microstenting, a compelling new approach for outflow enhancement that results in sustained reduction of IOP and anti-hypertensive topical medication use in OAG patients.


In this paper, the scattering measuring principle of turbidity is introduced firstly. The new type of turbidity sensor probe designed in this paper overcomes the deficiencies of existing technologies, which has higher sensitivity, strong anti-interference and can detect the turbidity accurately and continuously. The system designed with the core of MCU C8051F020 is presented. Then the design of turbidity sensor probe, data acquisition, processing and non-linear compensation are introduced in detail. Besides, in order to eliminate the impact of temperature on the turbidity measurement and improve the measurement accuracy, temperature measurement circuit has been designed. Test results have shown that the designed on-line turbidity-meter has some advantages: low price, high precision, easy operation etc. It can be widely applied in the fields of waterworks, industrial production, aquaculture, environmental protection and so on


The invention discloses a manufacture process for a eucalyptus core plate. The manufacture process comprises the following steps of: drying, groove planing, material cutting, plate joining, primary sanding, assembly, cold pressing, repairing, primary heat pressing, ash scraping, secondary sanding, surfacing, secondary heat pressing, edge sawing, polishing, inspecting, putting in storage and the like. The manufactured eucalyptus core plate has the advantages of good quality, attractive patterns on an edge, a smooth plate surface, large density, heavy weight, sensibility of thickness, easiness in processing, excellent nail holding force, non-deformation and the like. According to the manufacture process, core bars inside the eucalyptus are recycled and processed to form a eucalyptus core plate, thus the energy is saved, the cost is lowered, and the manufactured eucalyptus core plate can be applied in various fields of furniture industry.


. Objective/Context : The article describes the role of Colombia inthe Korean War between 1951-1954, proposing an analysis that links the context of the Cold War in Latin America, the violence in Colombia, and the features of the Korean conflict. Methodology : Based on new historiography of the Cold War and the concept of global history , the text exposes an analysis of primary and secondary sources to identify synchronicities between Internal Policies, the international context and the practices of military and political Colombian elites to participate


Abstract The removal of harmful cyanobacteria has recently become an important target in water management strategies. Various methods have been developed to eliminate these microorganisms including: (1) biological methods, especially with floating treatment wetlands and riparian vegetation; (2) physical methods with aeration, mechanical circulation, and hypolimnetic oxygenation; (3) chemical methods with coagulation and flocculation processes; (4) barley straw. We propose that the in situ mechanical-based micro-sieving process provides an opportunity for this to succeed in practice. The appropriate, selective technical parameters and techniques can result in successful water quality improvement, which is essential to meet Water Framework Directive goals and especially for public health. Additionally, micro-sieving used for removing Gloeotrichia can contribute to a significant reduction in internal phosphorus loads, a necessary step in lake restoration. The theoretically probable mean cell-bound P-content transferred with G. echinulata colonies (during strong blooms) can be as high as 48 mg L−1, and this potential P-load is usually deposited on lake bottoms. The removal of cyanobacterium can result in significant limitations of internal P-sources. The method presented above could be a promising, practical, easy-to-use, and cost-effective method for managing and limiting cyanobacterial blooms.


Presents an improved procedure, by using both surface and interior integral equations for conducting bodies of revolution, in which certain field components, such as the tangential E-field, vanish not only on the radiating surface, but also in the interior of the radiator, therefore the deficiencies of the previous procedure in the vicinity of the interior resonant frequencies can be overcome. A general computer program is written, and sample computations are given for a sphere. It is shown that a unique solution can be obtained using the improved method.


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A integrated circuit (IC) die element to provide a hybrid reconfigurable processor modules stacked. A processor module reconfigurable according to one embodiment disclosed herein is thinner microprocessor die device, memory die elements and / or FPGA die elements are stacked, extends through the thickness direction of the die or as having a structure in which these die elements are interconnected by a contact. Such processor modules, it is possible to increase the data sharing rate between the microprocessor and FPGA significantly, the effect of reducing the cost of manufacturing at the same time the finished assembly when improving the yield of the finished assembly. .FIELD 4


Forty seven isolates were separated from different tissus of matured rubber after strict surface sterilization.The amounts and species of endophytic bacteria in rubber demonstrated a decreasing trend in the tissues from root,inflorescence,bark,petiole,lamina and fruit.Corynespora cassiicola and Colletotrichum gloeosporioides isolated from rubber were used as indicative pathogens and two strains with relatively strong antimicrobial effect were screened.The colony figure observation,characteristic of physiological and biochemical and sequence analysis of 16S rDNA showed the two strains were Bacillus subtilis and B.mojavensis respectively.


Bilateral Investment Treaties (BITs) allow developing countries to trade some policy autonomy for improved access to internationally mobile capital. While the impact on capital flows is widely written about, BITs' impact on policymaking is typically studied more narrowly in the context of regulatory policy and "regulatory chill". We argue that the restraints that BITs place on governments also have important fiscal costs that should be accounted for. We locate those costs in two areas. First, many BITs have umbrella clauses that allow protected firms to challenge violations of side agreements that are typically more constraining than the BITs themselves and more likely to contain tax-specific constraints. Second, BITs undermine revenue generation by channeling economic activity into multinational corporations, which are among the least easily taxed part of the economy. Evidence from 105 developing countries from 1981 to 2009 supports our hypotheses, particularly as they relate to BITs with umbrella clauses.


Objective To investigate the effects of pravastatin on nitric oxide production in endothelial progenitor cells. Methods Total mononuclear cells(MNCs) were isolated from peripheral blood by Ficoll density gradient centrifugation,and cultured in vitro.After 7 days of culture.attached cells were stimulated with pravastatin(10 and 100μmol/L) for 48 h.The cells were identified by immuno-histochemistry and flow cytometry and tested the ability to intake the acLDL.The content of NO and the level of endothelial nitric oxide synthase(eNOS) mRNA were tested.Results Compared with control group,the content of NO and the level of eNOS of pravastatin group increased obviously(P0.05 ).Conclusions Pravastatin could increase the production of nitric oxide and the expression of eNOS mRNA in EPCs,which could improve blood vessel endothelium function.


The embedded-atom method of Daw and Baskes is used to calculate the reconstruction of the Au(100) surface. The state of minimum surface energy for a 5 x 5 unit cell is attained by adding five atoms to the surface layer, resulting in a 1 x 5 reconstruction giving a slightly buckled quasitriangular surface with 20% higher areal atomic density than the truncated surface. These results are compared with experiment and with the recent calculation of Ercolessi, Tosatti, and Parrinello. The experimental results and both calculations agree semiquantitatively.


This study aimed to identify the impact of the implementation of the corporate social responsibility "CSR" with its four dimensions as economical, legal, ethical, and discretional on the company's financial performance, by two common financial indicators : return on assets "ROA" and return on sales "ROS". Memorable, Almadar telecommunication company has been chosen as a case study because it is a unique one in the Libyan business filed which incurs the social responsibility activities by managerial structure and professional treatments. Consequently, relying on the data collection by multi tolls "questionnaire, interviews, and analysis of financial statements", additionally, testing the four sub-hypotheses by Pearson correlation test, the study became able to present satisfied and scientific evidence to recognize that, there is a significant relationship between the implementation of "CSR" and the enhancement of Almadar financial performance over all the four dimensions of "CSR", stated earlier.


The structure by X-ray crystallography of the valinomycin–cesium picrate complex has been determined by the heavy atom method. The crystal class was trigonal, space group P31, with unit cell dimensions a = b = 14.028(4) â, 31.888(10) Ǎ, Z = 3, filtered Mo radiation; the final value of R was 0.111 for 4088 reflections measured at − 170 °C. The enclosed cation was found to be too large for the cavity, causing the valinomycin to be incompletely closed and forming a weak bond with the picrate at the D-valyl end, which was the same end as had been previously found to be involved in the sodium complex. This result is in agreement with the proposal that the cation enters and exits by the D-valyl end.


In 2012 became reality James Boyle's desire exposed in his essay from 1997 regarding a politics of intellectual property concerning the great deal of attention that must be paid to the Intellectual Property. At that time Boyle was disappointed by the lack of attention from lawyers, scholars, legal academics and the media for the Clinton administration's proposal for copyright on the Net, a document that provided the blueprint of domestic and international regulatory efforts to expand intellectual property rights. Certainly this was not the case with ACTA where the public media forced by the private citizen's protests tried to weight both the benefits and the costs of the new protection standards brought by the new international convention. After those moments Intellectual Property regulations are no more an esoteric and arcane field, something that is only interesting and comprehensible to the practitioners in the field, but a matter of public interests like the environment which arouse the attention of all the persons. In this way we all become aware that intellectual property radiates beyond the legal frame and interferes with several aspects of our lives, including our free time and the tourism consequently.


This work has been carried out as part of a CRC-ACS research program. SUMMARY: There is an increasing demand within the composites industry for integrally-manufactured three-dimensional preform structures. Using and extending the basic principles of conventional weaving processes has allowed a wide range of such structures to be developed, as briefly summarised in this paper. Such integrally-woven preforms, however, lack reinforcing fibre in the bias directions (eg. +45 (cid:176) ) intermediate between the warp and weft. A detailed review of recent developments to overcome this limitation is presented in this paper, together with the type of integrally-woven multiaxial structure (eg. 5-axis) achievable. Although the details of implementation differ, these multiaxial weaving developments utilise the principles of lappet weaving, triaxial weaving, and cross-laying.


The ancient underground cavern of Longyou has a history of more than 2,000 years, and it exhibits a considerable value in archeology, history, science, and culture; therefore, its protection is of considerable significance. Investigating the development mechanism of vault cracks is an important part of the protection work. Most previous studies have been conducted from a single perspective. For an in-depth study, a multi-factor approach is used to conduct compre-hensive research based on mechanical analysis and monitoring analysis. The analysis shows that the vault cracks continue to expand and uneven settlement of vault increases gradually. Theoretical analysis and monitoring exhibit similar trends, which indicates that the vault is considerably damaged; therefore, a reinforced support technology is necessary. In this study, the Building Information Modeling (BIM) technology is considered for application to an ancient underground cavern. It has the potential to provide new ideas and visual materials to investigate and conserve the ancient underground cavern of Longyou. In addition, it would promote the wider application of the BIM technology in geotechnical engineering.


A spacecraft hurtles through the cosmos. For a brief period the craft has been manned, but the travelers have no control over its course, speed, or destination. During the endless flight, they depend on the supplies already on board or those that can be produced there. To endure the voyage, their house must be kept in order.

For awhile the travelers were few, supplies seemed unlimited, and there were numerous corners into which the refuse could be swept. But the crew increased in number more and more rapidly. Distribution of supplies became unsatisfactory, and the suspicion arose that the quantity might be inadequate. In a sense, the craft seemed to be getting smaller. Even the corners were filling up.


Growing soybeans in different row-spacings introduces competition. Competition begins when the immediate supply of a single necessary factor falls below the combined demands of all plants. This paper reviews the main competition factors of genotypes, light, water, nutrients and weed in responses to row spacings for the past four decades. It demonstrated that responses of soybean genotypes to row width differ among cultivars, which depend on seasonal rainfall and irrigation. Determinate types produce more yield in narrow-rows, and cultivars with lodging resistance should be adopted in narrow-spacings, but indeterminate soybean should also be used to optimize yields in certain system. Narrow-compared with wide-row soybean (Glycine max) cultivation increases light interception (LI) and dominant components for the increase come from LAI, light extinction coefficients and branch types. Water use efficiency (WUE) and evapotranspiration are not influenced by row spacing, but seed yield could be increased if irrigation is applied. Nutrient uptake is significantly affected by row spacing, seed yields and uptake of N, P, K in plants increases with decreasing row spacing, and the effects depend on the fertilizer levels. Other factors rather than row spacing affect nitrogen fixation. Weed density, peak time and periodicity of weed emergence are not affected by row spacing, but better complementary weed control by the herbicides at the used doses can be obtained in narrow spacing due to the reduced weed number and dry weight. More researches are required to investigate the physiological responses, nutrient and water uptake and translocation, light utilization at different layers of canopy and soil environment changes in different row-spacings.


The research follows the basic principles of "more emphasis on hardware and software, more emphasis on qualified indicators, more emphasis on mass satisfaction, and more emphasis on quantity and quality" In order to solve the problem of imbalance between urban and rural teachers, it is necessary to explore effective ways of balanced development of compulsory education from the five aspects of technical support and mechanism coordination, and to infiltrate modern information technology into the optimal allocation of teachers.


Using genetic sequencing (COI-5P, LSU, rbcL) to elucidate their phylogenetic positions and then morphological characters to distinguish each from existing species, three procumbent species, including two novel species, from warm temperate Northern Hemisphere waters are added to the recently resurrected genus Halopeltis J. Agardh: H. adnata (Okamura) comb. nov. from Korea, H. pellucida sp. nov. from Bermuda and H. willisii sp. nov. from North Carolina, USA. Prior to these reports, the genus was confined to the Southern Hemisphere and tropical equatorial waters of the Northern Hemisphere although the latter records lack molecular confirmation. These three additional species join the six known species presently residing in Halopeltis.


An animal model for the experimental study of small cell carcinoma of the lung (SCCL; human) has been developed. Tumors arising from continuous cell lines of cultured tumor cells as well as transplantable tumors of human SCCL in nude athymic mice have been characterized as to growth rate and morphology. The effect of antilymphocyte and antithymocyte sera and the sex of the host mouse were evaluated.


Surveying the history of the dematerialization of the art object, Racine discusses how the installations created by Boulet, Cadieux and Meigs derive from the artists' immediate experience. Landry emphasizes the strategies proper to each work. Includes a short story by Meigs entitled "The Western Gothic." Biographical notes. 32 bibl. ref.


The purpose of this study is to determine the needs for a mobile application which will be developed so that the problems faced by academics in intra-faculty communication can be solved and their professional development can be supported. A questionnaire form consisting of two sections was used by researchers as a data collection tool of the study. Frequency analysis was conducted on the data obtained from the academics who were included in the study. At the end of the study, it was concluded that academics experienced problems as regards the communication means they used in the faculty, that phone costs increased, lines were mostly occupied, meetings took too much time and e-mails occasionally were not delivered. It was found out that academics requested that intra-faculty communication should be performed through a mobile device and should be given educative information as regards their professional development.


This paper presents a fast sequencing algorithm for a mixed model assembly line with multiple workstations which minimize the total utility work and idle time. We compare the proposed algorithms with another heuristic, the Tsaibased heuristic, for a sequencing problem that minimizes the total utility works. Numerical experiments are used to evaluate the performance and effectiveness of the proposed algorithm. The Tsai-based heuristic performs best in terms of utility work, but the fast sequencing algorithm performs well for both utility work and idle time. However, the computational complexity of the fast sequencing algorithm is O (KN) while the Tsai-based algorithm is O (KNlogN). Actual computational time of the fast sequencing heuristic is 2-6 times faster than that of the Tsai-based heuristic.