This Article had drawn a conclusion that A Dictionary of South Yunnan Yi would produce an effect on the development of Yiology,because this is the dictionary which was written by the writer who was scholar and Bi Mo,who had put forward proposal of perspective of context,which was a product founded on wide experi- ence of studies and translation of Ancient Books in Yi language during 23 years.


The present invention discloses a method for preparing strawberry scorched rice, food belonging to the art, includes the following steps: (1) Pretreatment: Wash Fresh strawberries, strawberry juice into a juice stand, millet, rice wash stand; (2) cooking: glutinous rice, millet, rice boiled milk mixture; (3) mixing: honey, sugar, rice, red bean, strawberry juice, stir palm oil, placed in an oven of 160 ℃ baked 10min, to obtain the strawberry flavor rice crust. The method is simple, get rich strawberry flavor rice crust nutritional preparation according to the invention, the maximum extent to retain the unique flavor of strawberries with honey nutrition, red bean, milk, rice, millet, people of all ages.


mental health services A proposal to research acute mental health service users' perspectives of their work related needs was presented to a NHS Local Research Ethics Committee (LREC). This was a non-experimental project which involved a qualitative interview based methodology. The project sought to interview people while they were still users of acute mental health services. The LREC paid particular attention to the specific issues relating to this group who were deemed to be vulnerable. Notably there was concern as to the risk of coercion in the recruitment process. The researcher had proposed that, once potential participants had been given information about the project by a member of their care team, they would subsequently be approached, again by a member of their care team, for their decision. The committee expressed concern that this second approach risked coercion. Instead the committee proposed that there should be an 'opt in' telephone contact number / office on the information sheet for participants to call once their decision had been made. This amended proposal was initially agreed to during the LREC discussion. Subsequently the principal investigator became concerned that this amendment might unnecessarily exclude people with capacity to consent from participation. The researcher argued that people, who are recovering from acute mental health problems, whilst having the capacity to consent, often need prompting to remind them of any decisions they may need to take.


This study aimed to describe the figurative language of the soccer commentator in the final match of AFF Suzuki Cup 2016.
This research was a qualitative descriptive research. The data used in this research was 251 utterances of football commentator's speech in the final match of AFF Suzuki Cup 2016 containg figurative languages. Secondary data sources in this study were taken from the AFF Suzuki Cup 2016 final match that had been downloaded from youtube. Primary data source was taken from the AFF Suzuki Cup final match aired on RCTI TV station. Research method in this research was conducted through three stages of research as follows. (1) Method and technique of data presentation used was scrutinize method with tapping technique and advanced technique of noting. (2) Method and technique of data analyzing by using equivalent and distributional method. The determining tools are facts pointed or referenced by language or referent language by using the basic techniques of the determinant-sorting technique and advanced correlation of the equalizing technique (HBS). (3) The method of data presentation was using informal method.
The results on figurative language analysis of football commentaries in the final match of AFF Suzuki Cup 2016 had found four kinds of figurative as follows. (1) The figurative languages based on the choice of words consisted of two kinds of informal language and language style of conversation. (2) The language based on the tone was found in three kinds: simple style, noble force, and medium style. (3) The language based on the structure of sentence was found as much as two kinds of climax and repetition. (4) The language based on the directness of meaning was as follows. (A) The rhetorical language was found in three styles of polysyndeton, euphemism, and hyperbole. (B) The figurative language found consisted of seven kinds, namely similes, metaphors, personifications, allusions, epithets, synecdoche, and irony.


The goal of this research was to determine motor abilities that have the biggest impact on girls' performance of gymnastic floor elements. Sample consisted of 103 girls from fifth and sixth grades. They were subjected to the experimental program which included learning of gymnastic elements in the regular physical education classes. Quality of performing "Straddle forward roll", "Handstand" and "Round off" was evaluated by the competent gymnastic judges and their mark represented a dependent variable. Battery of 12 motor ability tests was applied as a system of independent variables. The relation between a system of independent variables and a dependent variable was estimated by linear regression analysis. Results showed that applied motor variables as a system of independent variables have statistically significant impact (p ≤ 0.05) on performance of all 3 gymnastic elements in girls. Observed individually, 5 motor ability variables had statistically significant impact on dependent variable, i.e. variables "Seated straddle stretch" and "Leg lifting lying aside", which evaluates flexibility, variables "Sit-ups in 60 seconds" and "Handgrip strength" for general strength evaluation and variable "20 meters dash" for explosive strength evaluation. Based on the results, the authors concluded that physical preparation is necessary before learning mentioned gymnastic elements. Thus, improving general and explosive strength and flexibility should be primary.


MIME(Multipurpose Internet Mail Extensions) is mainly used to transfer non-text data for e-mail.It is compatible with the old version of message format,which make those old application gateways can also process the information in MIME format,and adds many functions and can transmit binary data in e-mail.Aggregate document is an application of MIME format,which is used to gather root resource and subsidiary resources to the same message.Firstly this paper describes the formats of MIME and aggregate documents,and proposes a decoding algorithm for MIME format documents.Then on the basis of the algorithm,a decoding algorithm for aggregate documents is given.


We explore how minority- and women-owned suppliers lacking hard power manage asymmetric relationships with larger, more powerful buyers in the context of supplier diversity relationships. We examin...


For the requirements of the miniature and intelligen- ce demand, an ER source is designed. In order to meet the miniature demand, the piezoelectric ceramic transformer is selected as the step-up component, and the drive circuit is adopted the driving way to the single-end. To promote the intelligent degree of the high-voltage source, the system uses the PWM technology relying mainly on SG3524 and the microcontroller technology taking 80C196KC as the core. Based on these, the volume of ER source and system response rate are in line with the needs of ER devices.


Suitability of laboratory animals for each and every individual research is determined by their health status (Nicklas et al., 1999). The laboratory animals are prone to develop infections caused by various viruses (Elizebath et al., 2012). These pathogens cause infections of subclinical nature, difficult to manage, thus potentially influencing the outcome of the research (Nicklas et al., 1993; Collins and Parker, 1972).

https://www.ijcmas.com/9-8-2020/M. R. Srinivasan, et al.pdf


The only proteinogenic acid with a mercapto group, cysteine is the main participant in the binding of proteins and peptides to the surfaces of noble metals. A chiral molecule, it becomes a major player in surface patterning for chiral amplification, biosensing, and chiral catalysis. Here, we examine the interplay of molecule–surface and molecule–molecule interactions in the self-assembly process of monomers, dimers, and trimers of l-cysteine on a (1 × 2)-reconstructed Au(110) surface, and the implications for chiral recognition. Multiple adsorbed configurations of l-cysteine and l-cysteinate in neutral and zwitterionic forms were generated using molecular dynamics simulations, serving as starting points for further density functional theory (DFT)-based optimizations. We found that binding for both monomers and dimers was stronger at kink sites formed on the surface during the chemisorption process, and was unlikely to occur along the highly coordinated trough sites. In this, DFT calculations disagreed wit...


Learning graph structured data from limited examples on-the-fly is a key challenge to smart edge devices. Here, we present the first chip-level demonstration of few-shot graph learning which homogeneously implements both the controller and associative memory of a memory-augmented graph neural network using a 1T1R resistive random-access memory (RRAM). Leveraging the in-memory computing paradigm, we validated the high end-to-end accuracy of 78% (GPU baseline 80%) and robustness on node classification of CORA dataset, while achieved 70-fold reduction in latency and 60-fold reduction in energy consumption compared with conventional digital systems.


Malnutrition is an obstacle to the improvement of health in the various countries. Surabaya as a metropolis; in fact is still not exempt from of malnutrition. This aimed study is identify the role and function Posyandu on child nutrition, their knowledge, trust, food and habits, the nutrition status of children; and to construct a model of nutrition balanced for the child based on socio-cultural pattern, as an effort to repair the nutrition status, to achieve of the Millennium Development Goals (MDGs ). This was a descriptive-qualitative research. The data were obtained from Pegirian ini Semampir Sub-district and from Putat Jaya in Sawahan Sub-dis-trict. For the collection of data the researchers used interviews and observation. The result showed the Kampong Officals is thje effective way to approching people. The involvement of a leader of the people will give good psychological impact on the society. The society demanded even quality of health knowledge of all cadres. Cultural backgrounds including the belief in certain food and the meaning—culturally—of certain food were very influential to the selection of food. Application of PGS should also involve kindergarten or elementary school teachers in the region of RT/RW. Thus the question of nutrition was not just the duty of the cadres of Posyandu but also the responsibility of all those involved, such as the mother, local leaders, health workers, teachers and school children.


Abstract : White Sands Missile Range (WSMR) has a requirement to accurately determine the position and pitch attitude (V-angle) of missiles with respect to fiducials in a frame of visual information. This requirement is to effect the 'boresight correction,' i.e., the correction in angle to the mount encoder information for elevation and azimuth where the camera and associated optics are accurately positioned relative to the encoders. Since manual film reading is both relatively slow and quite tedious, a method for automatic film reading that is at least as accurate and as fast as manual reading would be a significant development for WSMR. During the past several years, a great deal of effort has been expended by WSMR to develop such a film reader, the end result being the development of the Automatic Programmable Film Reader.


How does philosophy in Australia treat the issue of how humans can or should relate to the natural world? The question is particularly interesting in the light of current interest in the environment, and because of the presence in this country of two cultures, Aboriginal and white, which contrast markedly on the issue of relations to the land. Philosophy in Australia is not simply Western philosophy. On this issue Aboriginal philosophies of nature must be considered. In this article I want to discuss the two Australian philosophical traditions, and the conflict between them, by focusing on two figures, one historical and one contemporary, which will help to crystallise aspects of the opposition in which they stand.


: The article offers an account of Raquel Tibol's art criticism in the context of Latin American narratives during the 1960s and 1970s. The study examines the political and aesthetic shifts, the tensions between form and content, and the importance of the political in the visual interpretations of the period. The aim is to place Raquel Tibol's art criticism in dialogue with her contemporar-ies in light of the emergence of the new Latin American left in order to determine the discursive nuances that emerged between theory and practice


Water balance is a euhydration index reflecting water intake and loss. It may be evaluated with the Water Balance Questionnaire (WBQ), a practical validated new tool that estimates intake from frequency intake of foods, beverages and drinking water and loss from excretion of sweat, urine and feces.


Two unique broad-band decametric arrays SURA and UTR2 are described in outline format. They are used for radio astronomy and radiophysical research (solar system investigations, ionospheric research, near-Earth plasma, etc). Both facilities were used last summer in 'bistatic' configuration, transmitting from SURA and receiving with UTR2. Moon and Sun were used as targets, NASA's WIND spacecraft was detecting with the RAD-2 receiver [5]. Preliminary results are shown.


From volunteer parents helping junior sports teams to professionals guiding All Blacks and Olympians, coaches play a huge role in keeping New Zealand active. People like Sport Wellington Community Coach Advisor Kelly Curr are tasked with building the framework that supports New Zealand's coaches.


Pseudo-first-order rate constants (k1 obs) for the reaction of MeNHOH with NCPH obey the relationship: k1 obs=k′b[MeNHOH]T2 where [MeNHOH]T represents total concentration of N-methylhydroxylamine buffer. The rate constants, k1 obs obtained at different total concentration of acetate buffer ([Buf]T) in the presence of 0.004 mol dm−3 MeNHOH follow the relationship: k1 obs=kb[Buf]T. The values of acetate buffer-catalyzed rate constant (kb) at different pH reveal the occurrence of both general base- and general acid- or general base-specific acid-catalysis in the reaction of MeNHOH with NCPH. © 1997 John Wiley & Sons, Inc. Int J Chem Kinet 29: 647–654, 1997.


Facing the upgrade of requirements both in functionality and role of CAD in the lifecycle of product development, four research issues are presented, namely easy operation and embedded intelligence, network-based collaboration, data sharing, and function enhancement. The three potential solutions for network-based collaboration are summarized and four approaches for solving data sharing are outlined. Four key problems for function enhancement are pointed out as well. In conclusion, authors point out that all the solutions, approaches and key problems mentioned in the paper are far from to reach the ideal solution, so the efforts to further improvement would be endless.


Abstract : Electromagnetic waves propagating along the ground-air interface are influenced markedly by terrain features. Previous studies have dealt extensively with abrupt changes in surface properties (modeled in terms of surface impedance), or abrupt changes in height as represented by precipitous hills or valleys, on the convexly curved earth's surface. When the terrain changes gradually, as in the presence of smooth hills or depressions, it is necessary to consider the effects of variable concave surface curvature, and more generally those of a gradual change over from concave to convex, on the signal propagation characteristics. Of special interest are the fields observed on or near the surface when the source is also situated on or near the surface. This paper is concerned with a review of earlier work on the concave surface problem, and with a summary of our current effort to adapt and extend these results to ground wave propagation. (Author)


For high performance requirements, P/PI-cascade feedback controlled miniature servo axes often provide insufficient damping of structural vibrations. The axis performance can be improved significantly by state space control extensions that are meanwhile available for commercial machine tool control systems. The benefit of additional load state feedback depends directly on the suitable state observation or capturing location in the machine structure. This contribution explains the state space control extension application for miniature drives and elucidates the achievable benefit by an exemplary linear servo drive.


Nitrogen, the principal component of the atmosphere, is still being released from the earth's crust, as is evident from the high values of the nitrogen fugacity within the earth, particularly in some petroliferous basins. However, the exact flux varies considerably on a regional scale and is directly related to geotectonics. The high nitrogen concentrations and fugacities at depth are important to solving the problem of the origin and status of the earth's nitrogen respiration. The authors find that the nitrogen levels in oil and gas pools correlate much more closely with characteristics of the basement than with those of the sedimentary section. Levels are particularly high on the margins of ancient cratons and above medium massifs. 20references, 3 figures.


: Some eeological considerations the distribution pattern of egg, larval (pupal) and imaginal populations in a cemetery of central The mean the observed individual counts in order to analyze the distribution pattern of the mosquitees of each stage. The results indicate that the basie components of the spatia] distribution seem to be groups of several individuals, and that such small groups of each stage mosquito distribute aggregatively in the area. Two transforrnation compared in their ethciencies stabilizing variate distribution, the former transformation the ]atter.


The space laser emission energy distribution of different continuous operation settings depends from many factors, first on the settings design. For more accurate describing of multimode laser emission energy distribution intensity the experimental and theoretic model, which based on experimental laser emission distribution shift presentation with given accuracy rating in superposition basic function form, is proposed. This model provides the approximation error only 2,2 percent as compared with 24,6 % and 61 % for uniform and Gauss approximation accordingly. The proposed model usage lets more accurate take into consideration the laser emission and working surface interaction peculiarity, increases temperature fields calculation accuracy for mathematic modeling of laser treatment processes. The method of experimental laser emission energy distribution studying for given source and mathematic apparatus for calculation of laser emission energy distribution intensity parameters depended from the distance in radial direction on surface heating zone are shown.


In recent years, Newton's method has been generally accepted as a superior algorithm for solving power flow problems. But the introduction of generator var limits, area-interchange control, load-tap- changing (LTC) transformers, and variable phase shifting transformers has significantly increased the solution times (compared with a fixed system). This paper shows how LTC transformers and variable phase-shifting transformers may be automatically adjusted by the Newton algorithm, thus complementing a previous inclusion of the area interchange control variables within the Newton algorithm [1]. Tests of the new method for adjusting LTC transformers and phase shifters indicate a significant overall saving in solution time.


The deposition of particulate soil on to a fabric in a wash system has been treated as a particular case of the general colloid stability theory of Derjaguin, Landau, Verwey & Overbeek. The zeta potentials on the fabric and the soil in detergent solutions have been calculated from electrophoretic mobility measurements. The colloid stability of the systems was determined by a sedimentation method. In particular, it is shown that the anti-redeposition action of sodium carboxy-methyl cellulose may be adequately explained by repulsive electrostatic and attractive van der Waals forces.


AUX air-conditioning brand is one of the leader of China's air-conditioning brands, which is created by AUX Air-conditioning Co., Ltd. This essay involves analyses using strategy tools and frameworks such as Porter's five forces analysis and Value chain analysis.


Flocculation is one of the effective and inexpensive methods for the large scale harvesting of microalgae. In this work, ferric chloride was chosen as the flocculant agent for treating the microalgae, volume of ferric chloride(X1) and level of pH(X2) were chosen as the two independent variables in the 2 factorial experiment. The linear approximate equation of the yield response surface is y= 91.75 + 5.25 X1 + 1.75 X2. Based on the method of the Path of Steepest Ascent, another 5 experiments were tested by moving through the experimental region along a path that yields the maximum increases in the response. In conclusion, sedimentation efficiency would reach to the top 99% when the volume of added ferric chloride solution (concentration 1 mol/L) is 0.44ml per litre and pH value is 8.45.


Purpose – Because of global environmental concerns, sustainable design has become a mainstream building design goal in recent years. Sustainable development is even more urgent in the light of global climate change. This paper aims to examine the contributions which building information modelling (BIM) can make to the production of sustainable building designs.Design/methodology/approach – Various research methodologies have been adopted, including literature review, design tool analysis, a case study and structured face‐to‐face interviews. Data collected were synthesized as part of the research process.Findings – BIM is found to be ideally suited to the delivery of information needed for improved design and building performance. Two most significant benefits of BIM for sustainable building design are: integrated project delivery (IPD) and design optimization. However, there are also barriers to adopting BIM for sustainable design.Research limitations/implications – This paper does not attempt to address ...


We have previously suggested that the recognition of a cross‐reactive epitope on the 5‐HT4 receptor and the 52‐kDa SSA / Ro protein by serotonin‐antagonizing autoantibodies could explain the electrophysiological symptoms of congenital heart block in neonatal lupus. To confirm this hypothesis, we immunized female mice with four synthetic peptides corresponding to the recognized epitopes. All mice developed anti‐peptide antibodies, which cross‐reacted with the Ro52 and 5‐HT4 receptor peptides and recognized both cognate proteins. Peptide‐immune mice were mated. The pups from mice immunized with the Ro52 peptides had no symptoms of neonatal lupus apart from bradycardia. However, pups from mice immunized with the 5‐HT4 receptor peptides and bradycardia, atrioventricular block of type I or II, longer QT intervals, skin rashes and neuromotoric problems. The 5‐HT4 receptor was detectable in the different fetal tissues affected (heart, skin and brain) by immunohistochemistry. Hearts from diseased pups were less developed and showed disorganized myocardial hyperplasia, compared to the normal littermates. These results demonstrate that the serotoninergic 5‐HT4 receptor is the antigenic target of physiopathological autoantibodies in neonatal lupus.


After an early onset over Kerala on 23 May 2009, further advance of the monsoon over the Indian region was delayed
by about two weeks with the monsoon restricted to the west coast and southern peninsula until 24 June


ABSTRACT There exists an urgent need to develop licensed drugs and vaccines for the treatment or prevention of filovirus infections. FGI-103 is a low-molecular-weight compound that was discovered through an invitro screening assay utilizing a variant of Zaireebolavirus (ZEBOV) that expresses green fluorescent protein. Invitro analyses demonstrated that FGI-103 also exhibits antiviral activity against wild-type ZEBOV and Sudanebolavirus, as well as Marburgvirus (MARV) strains Ci67 and Ravn. Invivo administration of FGI-103 as a single intraperitoneal dose of 10 mg/kg delivered 24 h after infection is sufficient to completely protect mice against a lethal challenge with a mouse-adapted strain of either ZEBOV or MARV-Ravn. In a murine model of ZEBOV infection, delivery of FGI-103 reduces viremia and the viral burden in kidney, liver, and spleen tissues and is associated with subdued and delayed proinflammatory cytokine responses and tissue pathology. Taken together, these results identify a promising antiviral therapeutic candidate for the treatment of filovirus infections.


Monolithic integration of loading capacitors into the X -band frequency selective surfaces (FSSs) based on ring slots is investigated as a means to control the frequency response of the FSS. Ring slots and integrated capacitors are formed on a microwave-friendly substrate using multistep thin-film deposition and patterning. Numerical simulations and experimental measurements are performed to extract the capacitance values and quality factors of the fabricated capacitors. It is proven that these capacitors in the range of 0-120-fF shift congruently the resonant frequency of the ring slot FSS from 11.8 to 8.14-GHz. Quality factors of the fabricated capacitors are estimated to be within the range of 50-150.


A modelling environment for the geometrical, topological and functional specification of mechatronic systems is presented. The close coupling of real model components and their virtual counterparts allows a synchronous construction of real and virtual prototypes and their evaluation.


On the example of one of the successful sectors of the Russian industry — the production of large diameter pipes (LDP) for trunk pipelines, the relationship between corporate governance and industry development is explored. At present, the specificity aspects of corporate governance in Russia leads to a short planning horizon, the high role of informal rules and the strong dependence of the company development vector on the controlling shareholders (company owners) interests. The owners of LDP companies decide to increase investment and production capacity under the conditions of demand drop for LDP. At the same time, the LDP demand drop poses a problem of significant underloading of capacities, which as a result may lead to a dropin the level of pipes production competencies and the industry product quality level reduction from achieved in 2014–2015 point. The article considers the configuration of key aspects of the Russian LDP production: corporate governance, capacity utilization, which determines the accumulation and loss of competencies, as well as the product quality.


PN code phase has been approximately synchronized after PN code acquisition. But code phase is keeping changing constantly under high dynamic environment, and then the correlation peak will be losing lock rapidly if without any compensation approach. Thus how to design code tracking loop under high dynamic environment has become a key step in spread spectrum transponder. This paper begins with the analysis of loop characters, not only derives the sensitivity of phase detector, but also describes the design of loop filter parameters, and at last it gives the simulation results. The analysis and simulation results indicate that it can achieve the goal of accurate tracking of code phase by this kind of code tracking loop.


Wild rice (Zizania latifolia), a rhizome grass species of high stem emerged plant, is a typical clone plant. Tillering nodes of wild species can propagate two generations and live 2 years in general, of which the oldest lives up to 3 years in the wetland conditions of the Songnen Plain China. The rhizome can live one year in general, occasionally up to 2 years. There are two age classes in both tillers and rhizomes of the clone population, and the 1st age class constitutes the majority, which are 74.1% tillers, 89.4% accumulative rhizome length, 92.8% dead standing biomass and 92.7% rhizome biomass. The potential clone population consist of rhizome buds of 0 age class and tillering node buds of 1 age class, of which 0 age class constitute the majority, 84.8%. The number of vegetative buds is 10 times more than the tillers. The clone population has a great popentiality for growing rapidly.


III-V junctionless gate-all-around (GAA) nanowire MOSFETs (NWFETs) are experimentally demonstrated for the first time. Source/drain resistance and thermal budget are minimized by regrowth using metalorganic chemical vapor deposition instead of implantation. The fabricated short channel (Lg=80 nm) GaAs GAA NWFETs with extremely scaled NW width (WNW=9 nm) exhibit excellent gm linearity at biases as low as 300 mV, characterized by the high third intercept point (2.6 dbm). The high linearity is insensitive to the bias conditions, which is favorable for low power applications.


A split-post dielectric resonator was used to measure solid laminar dielectric specimens which had been previously measured by a number of other techniques. Detailed error analysis of permittivity and dielectric loss tangent measurements has been performed. It was proved that, by using a 4 GHz split post resonator, it is possible to measure permittivity with uncertainties down to 0.3% and dielectric loss tangent with resolution 2/spl times/10/sup -5/ for well machined laminar specimens.


For the second time in just a few years, Belgium recently faced a profound political and institutional crisis. Since constitutions are the ultimate means of building and sustaining a just and stable politico-institutional order, these crises raise the question of what role the constitution plays in channeling and/or constraining the political state of affairs. This is a most pressing topic, especially since the dominant theory about why and how countries such as Belgium are able to function as stable polities also claims to be indicative of the democratic quality of these countries. I submit that the Belgian case can indeed be instructive in telling us a bit more about the constitutional conditions that are, if nothing else, at least not antagonistic to societal stability. [R, abr.]


This article analyzes the contents and requirements of advanced study of nurse teaching in the intervention operation room.In light of the characteristics of intervention operations,it discusses some problems in nursing teaching regarding related nursing theory,and mastery and study of intervention instrument management theory.


The railway switch failure prediction for railway signal equipment maintenance plays an important role. The paper put forward railway switch failure prediction algorithm based on least squares support vector machine, and chose five characteristic indexes composed of railway switch failure prediction models characteristic input vectors. It reduces the dimension of input vectors, shorten the least squares support vector machine training time, and use a pruning algorithm to accelerate the computing speed maintaining a good regression performance at the same time. The experiment proved that railway switch failure prediction algorithm has strong self-learning ability and higher prediction accuracy based on least squares support vector machine. And it can accelerate the speed of switch failure prediction and improve the accuracy and reliability of railway switch failure prediction.


s 1. Ellaithy A, Xu Y, Kawano T, Gonzalez-Maeso J, Logothetis D. Ionic Lock: Functional Role in Activation of Metabotropic Glutamate Receptor 2. Poster presentation at Chemistry and Pharmacology of Drug Abuse (CPDA) conference, Boston, MA, August 2017. 2. Xu Y, Ellaithy A, Kawano T, Gonzalez-Maeso J, Logothetis D. Ionic Lock: Functional Role in Activation of Metabotropic Glutamate Receptor 2. Biophysical Journal. 2017;112(3):530a. Poster presentation at Biophysical Society meeting, New Orleans, LA, February 2017. 3. Ellaithy A, Younkin J, Baki L, Logothetis DE. A positive allosteric modulator of metabotropic glutamate 2 receptor alters 5-HT2A receptor signaling in a heteromeric complex. Poster presentation at Biophysical Society meeting, Baltimore, MD, February 2015. 4. Ellaithy A, Helmy B, Salama M. Does Colchicine possess a neuroprotective effect in Parkinson's disease? Poster presentation at University Medical Center Groningen ISCOMS, June 2012, Netherlands.


Road maintenance is an important element of maintenance of road infrastructure and enables smooth traffic flow. This is the reason why road maintenance service is organized in order to preserve and maintain satisfactory technical conditions of the road and provide smooth traffic flow and road safety. Road maintenance is divided into regular and emergency maintenance operations. Regular maintenance works are carried out continuously throughout the year. Emergency maintenance includes work on smaller reconstructions such as the renovation or replacement of pavement. The organization of winter maintenance is essential because of the snow and ice on the road surface that reduce safety and traffic flow capacity. Winter maintenance depends on the geographic location, altitude, climate, and the work of winter service and their response depends on organization and getting precise and timely information about road conditions.


The present invention provides an apparatus for the gap between the sealing member for reducing the gas turbine. The gas turbine (2) of the embodiment has: a first arcuate member (38) and a second arcuate member (40) adjacent; section (42) and connected at a first end of the first arcuate groove member (38) two grooves (44); a first seal member (42) and a second arcuate member (40) adjacent to the first groove of the first groove set (46) (50); providing a second slot (44 ) a second sealing member (52) adjacent the second groove (48) and a second arcuate member (40), between the first sealing member (50) and a second seal member (52) remains a gap (54) is coupled between the cover and substantially on the first sealing member (50) and a second seal member (52) a first seal member (50) and a second seal member (52) and; gaps (54) the connecting member (56).


The utility model belongs to the airplane landing gear technology, and relates to an improvement of a strut lock in the landing position of an airplane landing gear. The airplane landing gear strut lock mechanism provided by the utility model comprises lug pieces (10), a compression spring (11), an upper strut (12), a bracket (13), a knuckle bearing (14), a roller (15), a lower strut component (16), an electric door (17) and a lock hook (20), wherein a connecting hole of a main connecting double lug (10) is connected with a retractable action cylinder; and unlocking and locking of a strut lock can be performed through the retractable action cylinder. When the landing gear is in the landing position, the lock hook (20) is clamped on a lug boss of the upper strut (12) through the retractable action cylinder, and at the same time, the movement of the lower strut component (16) is limited by the roller (15) installed on the upper strut (12). The airplane landing gear strut lock mechanism provided by the utility model has the advantages of simple structure, small occupied area and light weight, is fixed reliably, and can undergo and deliver ground loads, thereby being very suitable for light airplanes.


No one doubts that a sounding body is distributing energy, and that a sound-wave is one mode of transmitting energy; but in most practical cases the quantity of energy involved is so small as to elude easy measurement, and the problem is sometimes complicated by physiological questions. Attention has been directed mainly, in acoustical measurements, to finding the velocity of sound in various media, and to determining the vibrationfrequency of the notes of the scale and of sounding bodies; this last problem has been solved experimentally in more than a score of ways, from the simple· rod-tonometer that was so serviceable in the hands of Chladni and Scheibler, up to the refinements of Mayer's electrical method, and Rayleigh's, Macleod and Clarke's, Poske's and Michelson's methods, and Konig's fork-clock. But from time to time a number of contributions have been made to this subject of energy. Our text· books, however, so seldom refer to them that one is surprised on looking up the matter to see how much has been done; yet in so disconnected a way that considerable connecting matter is needed. It is hoped that this paper may supply a part of what is needed. In saying that our books give us little on the sub· ject, of cOllrse it is meant few quantitative results; we find easily enough the law of inverse distances given, with the pre· tended proof, by striking fOllr bells twice as far from the ear as a single similar bell is; the use of resonance cases and soundingboards is familiar, of speaking and hearing trumpets, of the deadening effect of a non-homogeneous atmosphere, etc.; all these and similar things are pleasantly told, with more detail than in any other book I have met with, in Radau's Wonders of Sound. In recent years the question of Energy has come up in new ways, as in finding the Potential at any point due to a vibrating body, and in deducing the equations of harmonic motion as is done by Lord Rayleigh, from assuming that the sum of the kinetic and potential energy in the vibrating body is constant; but here as before we have no numerical data given to help toward clear thinking. We may consider our subject under three heads: A. Instruments to which a store of energy is imparted at once, and which are then left to themselves; E:'. g. tuning fork, bell, and all stringed instruments. B. Instruments that store up little or no energy, and so need a constant supply from outside: e. g. all wind and reed instru· ments, singing flames, and the voice.


Recently, nanodiamond particles have attracted increasing attention as a promising nanomaterial for its biocompatibility, easy functionalization and conjugation with biomolecules, and its superb physical/chemical properties. Nanodiamonds are mainly used as markers for cell imaging, using its fluorescence or Raman signals for detection, and as carriers for drug delivery. For the success of these applications, the biomolecule associated with the nanodiamond has to retain its functionality. In this work, the protein activities of egg white lysozyme adsorbed on nanodiamond particles of different sizes is investigated. The lysozyme nanodiamond complex is used here as a protein model for analyzing its structural conformation changes and, correspondingly, its enzymatic activity after the adsorption. Fourier-transform infrared spectroscopy (FTIR) is used for the analysis of the sensitive protein secondary structure. To access the activities of the adsorbed lysozyme, a fluorescence-based assay is used. The process of adsorption is also analyzed using UV-visible spectroscopic measurements in combination with analysis of nanodiamond properties with FTIR, Raman spectroscopy, and ζ-potential measurements. It is found that the activity of lysozyme upon adsorption depends on the nanodiamond's size and surface properties, and that the nanodiamond particles can be selected and treated, which do not alter the lysozyme functional properties. Such nanodiamonds can be considered convenient nanoparticles for various bioapplications.


The concept of fractional-order control (FOC) means controlled systems and/or controllers are described by fractional-order differential equations. Expanding derivatives and integrals to fractional orders is by no means new and actually has a firm and long-standing theoretical foundation. Interest in this subject was evident almost as soon as the ideas of classical calculus were known. The earliest more or less systematic studies seem to have been made in the beginning and middle of the 19th century by Liouville, Holmgren, and Riemann, although Eular, Lagrange, and others made contribution even earlier [1]. Parallel to these theoretical beginnings was the development of applying fractional calculus to various problems [1]. As to fractional calculus' application in control engineering, FOC was introduced by Tustin for the position control of massive objects (see Figure 1) half a century ago in 1958, where actuator saturation requires sufficient phase margin around and below the critical point [2]. The characteristic equation of the above close-loop 1/s system with variable gain factor A is 1 + A( jω) = 0 (1)


Currently, computer simulation in virtual reality systems has a special status. In order for a computer model to meet the requirements of the tasks it models, it is necessary that the mathematical apparatus correctly describe the simulated phenomena.
In this monograph, the simulation of pursuit problems is carried out. An adaptive modeling of the behavior of both pursuers and targets is carried out. An iterative calculation of the trajectories of the participants in the pursuit problem is carried out.
The main attention is paid to the methods of pursuit and parallel rendezvous. These methods are taken as the basis of the study and are modified in the future.
The scientific novelty of the study is the iterative calculation of the trajectories of the participants in the pursuit task when moving at a constant speed, while following the predicted trajectories.
The predicted trajectories form a one-parameter network of continuous lines of the first order of smoothness. The predicted trajectories are calculated taking into account the restrictions on the curvature of the participant in the pursuit problem.
The fact of restrictions on curvature can be interpreted as restrictions on the angular frequency of rotation of the object of the pursuit problem.
Also, the novelty is the calculation of the iterative process of group pursuit of multiple targets, when targets are hit simultaneously or at specified intervals. The calculation of the parameters of the network of predicted trajectories is carried out with a curvature variation in order to achieve the desired temporal effect.
The work also simulates the adaptive behavior of the pursuer and the target. The principle of behavior can be expressed on the example of a pursuer with a simple phrase: "You go to the left - I go to the left." This happens at each iteration step in terms of choosing the direction of rotation. For the purpose, the principle of adaptive behavior is expressed by the phrase: "You go to the left - I go to the right."
The studies, algorithms and models presented in the monograph can be in demand in the design of autonomously controlled unmanned aerial vehicles with elements of artificial intelligence.
The task models in the monograph are supplemented with many animated images, where you can see the research process.
Also, the tasks have an implementation in a computer mathematics system and can be transferred to virtual reality systems if necessary.


With the increasing incidence of malfunctions of air transportation system due to severe weather, the Air Traffic Flow Network Rerouting (ATFNR) is playing an important role in improving the global efficiency of air traffic. This paper adopts a multi-objective optimization model to solve the ATFNR problem to make a tradeoff between the total delay costs and the airlines fairness. Meanwhile, a specially-designed algorithm based on multi-objective comprehensive learning particle swarm optimizer (MOCLPSO) under the cooperative co-evolution framework is presented to handle this large scale, multi-objective real-world optimization problem. The empirical studies show that the presented methodology is effective and outperforms an existing approach to ATFNR problem as well as two well-known Multi-Objective Optimization Algorithms.


Twenty-one shade and flowering trees were planted in a cultivated opening surrounded on three sides by gypsy moth-infested forest stands. Three Malus cultivars, Salix babylonica, Acer platanoides 'Royal Red' and 'Crimson Sentry,' and Prunus cerasifera 'Thundercloud' were the most heavily defoliated (30-70%) each year. Acer rubrum 'Northwood' and 'October Glory,' Tilia cordata 'Greenspire,' and Tilia americana suffered low to moderate defoliation (4-20%). Acer platanoides 'Emerald Queen,' Acer saccharinum, Fraxinus pennsyloonica 'Marshall Seedless,' Platanus × acerifolia 'Bloodgood,' Pyrus calleryana 'Redspire,' Acer platanoides 'Deborah,' Prunus serrulata 'Kwanzan,' Gledttsia triacanthos var. imermis 'Sunburst,' and Magnolia × soulangtana lost <4.0% of their foliage because of gypsy moth feeding injury. A wide range of host plant resistance levels among cultivars of A. platanoides and species of Acer and Prunus indicates a need for evaluating cultivars of shade trees susceptible to gypsy moth. In a separate study at the same site, Acer rubrum 'Northwood' planted in the cultivated opening was more heavily defoliated (14.4%) by gypsy moth larvae than similar trees planted in the adjacent forest stand (6.6%).


the recent surge of interest in developing philosophical conversations across the Americas has often taken democracy as its theme. For example, in October 2010 the inaugural issue of the Inter-American Journal of Philosophy was published, leading off with an article by Guillermo Hurtado: "El dialogo filosofico interamericano como un dialogo para la democracia" ("Inter-American Philosophical Dialogue as a Dialogue for Democracy"). Hurtado proposes that "one of the guiding lines of the dialogue be democracy understood not simply as a form of government but also as an ideal of our life together" (10). No one associated with the Society for the Advancement of American Philosophy (SAAP) needs to be convinced that North American philosophy has a great deal to contribute in this regard. Simply scanning the paper and panel titles of the SAAP 2011 Conference indicates that democracy will be treated from the perspectives of James, Royce, Dewey, Addams, Follett, Du Bois, King, and Rorty. In response to Hurtado and others who have called for philosophical dialogue across the Americas,3 my article focuses on some aspects of democracy that appear when considering the concept of el pueblo and its role in the Latin American liberation philosophy of Enrique Dussel.


Today Samba is well known brand of banking sector of Saudi Arabia. Samba Financial group is growing and emerging entity in the Saudi Arabia. Samba Bank comes out with number of innovations in its products and services along with following all the marketing trends like CRM and other marketing efforts for the customer satisfactions, at the same time simultaneously maintaining its bottom line. The present case is an attempt to indicate the major strategies of Samba bank and how it is moving strategically in the new age of Globalizations. The first part of the paper will cover the profile of bank and its achievements, the second part will highlight the strategies mainly focused on Takeover, mergers& acquisition and expansions, along with its services and product innovations and also covering quality of services, diversity and leadership in banking industry of Saudi Arabia. An attempt has been made to analyze the overall corporate strategy of samba bank in the new age of Banking.


Ferromagnetic materials, such as steel, are used for shielding of power and telecommunication cables. These shields often provide path for currents during faults or lightning and are important for the integrity and safety of electrical systems and devices. Since such currents might be with low- or high-frequency content, and of low or high intensity, ferromagnetic shield behavior might be quite different due to hysteresis. This paper describes a method for analyzing the dynamic behavior of ferromagnetic cable shields based on the Jiles model of hysteresis. The solution is implemented in ATP-EMTP, which allows one to analyze the complex behavior of ferromagnetic cable shields in conjunction with that of the other elements of the power system. Due to limitations of the model of hysteresis, application of the proposed model is limited to frequencies up to about 10 kHz. The model is illustrated for a practical 100-m-long cable.


This article examines the different conceptions of racial identity and 'geography' in two landmark Supreme Court decisions, Shaw v. Reno (1993) and Easley v. Cromartie (2001). Both decisions evaluated similar Congressional redistricting plans in North Carolina, but reached opposite conclusions. In Reno, the Court based its reasoning on the 'objective', 'natural' and 'rational' geography of North Carolina. Such geographic relationships create political communities and constrain the way in which state legislatures can draw electoral districts. In contrast, the Easley decision based its reasoning on voting behaviour, and makes an implicit appeal to deliberative democratic principles. From this perspective, political relationships create the geographic relationships defined by Congressional district boundaries. Where the Reno decision treats race as an arbitrary social distinction that the state should not use as the basis of political representation, the Easley opinion argues that the state can consider differences in racial voting behaviour during the redistricting process. More fundamentally, the Easley decision implies that racial identity is formed by deliberative political communities, rather than being an objective, static characteristic. This suggests that disputes over spatial relationships are critical to the construction of hegemonic racial identities, and that space is fundamental to the conception of racial difference.


We provide upper and lower bounds in consistency strength for the theories "ZF + ¬ACω + All successor cardinals except successors of uncountable limit cardinals are regular + Every uncountable limit cardinal is singular + The successor of every uncountable limit cardinal is singular of cofinality ω" and "ZF + ¬ACω + All successor cardinals except successors of uncountable limit cardinals are regular + Every uncountable limit cardinal is singular + The successor of every uncountable limit cardinal is singular of cofinality ω1". In particular, our models for both of these theories satisfy "ZF + ¬ACω + κ is singular iff κ is either an uncountable limit cardinal or the successor of an uncountable limit cardinal". There are many instances in the literature where choiceless large cardinal patterns are initially forced from strong hypotheses which one later sees can be weakened somewhat. For example, it is shown in [4] that the models constructed in [11] from an almost huge cardinal can actually be ∗2000 Mathematics Subject Classifications: 03E25, 03E35, 03E45, 03E55. †


Josephson junctions of high-Tc Y-Ba-Cu-O films have been successfully fabricated by ablating the films with a pulsed excimer laser. No degradation of the resistance-vs. -temperature characteristics of the films due to the laser ablation was found. The effect of radio frequency irradiation was investigaed at 77K. Clear Shapiro steps were observed under the microwave (8GHz) and millimeter-wave (94GHz) irradiation.


The present application provides a primer set for genotyping M. tuberculosis selected from the group consisting of primer sets 1-25 (SEQ ID Nos. 1-50), and also provides an extension primer for genotyping M. tuberculosis selected from one of the group consisting of SEQ ID Nos. 51-75. The present application provides a combination of single-nucleotide polymorphism markers of M. tuberculosis. Further, the present application provides a method and a kit for genotyping M. tuberculosis.


The researcher, as the central figure in this study, specifically expounded his views on the growth and setback of teaching processes, and participated in the after-school homework tutoring. The researcher deeply interpreted the implicit knowledge from online tutoring by exploring the tutor's teaching diaries, online teaching materials, and discourse between tutor and student. At the end of the semester, the central figure turned a novice into an expert and eventually mastered the adjustment of teaching materials, teaching procedures, teaching directions as well as teacher/student interaction. In addition to developing teaching specialties in long-distance education, the use of technology, cultural empathy and affective factors were key factors to maintain the quality of the after-school homework tutoring. The researcher reconstructed the new comprehension of disadvantaged students, rural area education and online tutoring when incorporating previous experience into the online tutoring program.


Through the observation and testament of the surrounding rock of Caoyuling Tunnel, this paper analyzes the substantial components and engineering geological property of the sandy mudstone.


Studies have shown that symptomatic improvement of cryptosporidiosis in immunocompromised patients is possible following treatment with" hyperimmune" colostrum containing anti-sporozoite antibodies from cattle immunized with Cryptosporidium parvum antigens. The contribution to immunity of antibodies developed during Cryptosporidium infection is unclear, however. Previously, we showed that scm ( severe combined immunodeficiency) mice acquired immunity to C. muds infection ifinjected with immunocompetent splenocytes. To investigate the role of the splenic donor B-cells in this immunity, groups of CB-17 scm mice received BALB/c splenocytes, or splenocytes depleted of B-cells by immunomagnetic separation before infection. Both groups recovered from infection at similar times and displayed little difference in patterns of oocyst excretion. Subsequently, B-cells and serum anti-parasite antibodies were found only in mice reconstituted with unfractionated spleen cells. These results suggested that B cells may not normally be required in immunity against Cryptosporidium. MJIRI, Vol. 13, No.2, 119-123, 1999


The Swiss Centre for Innovations in Learning (SCIL) promotes competent and meaningful use of new technologies in university and corporate education. SCIL provides consulting, coaching, research, and moderation to accelerate progress towards enhanced quality in education. The centre was founded in March 2003. It is initiated and supported by the GEBERT RUF FOUNDATION for five years. Ingrid Schonwald, Dieter Euler, Jasmina Hasanbegovic, Sabine Seufert


We show that Fe3+, Co2+, Ni2+, and Cu2+ fixed by diamino-functionalized MCM-41 and MCM-48 work as adsorption centers for arsenate ions. The stoichiometry of the N/metal cation was determined as well as the As/metal cation for the adsorption of arsenate. The effectiveness of the removal of arsenate from a dilute solution is ordered according to Fe3+ > H+ ∼ Co2+ > Ni2+ ∼ Cu2+, which is slightly different from the adsorption capacity:  Fe3+ > Co2+ ∼ H+ > Ni2+ > Cu2+. The distribution coefficients, Kd, exceed 200 000 at [arsenate] < 100 ppm in Fe/NN-MCM-41. The Fe center binds nearly three arsenate ions, which allows the adsorption capacity of Fe/NN-MCM-48 to be one of the largest at 2.5 mmol (g of adsorbent)-1 among the adsorbents of arsenate. The difference between the meso-framework structures appears in their adsorption capacity; cation/NN-MCM-48 adsorbs a larger amount of arsenate than cation/NN-MCM-41. This is mainly caused by the difference of cation content in these functionalized mesoporous silicas. ...


Three dimensional photoelastic models were used to make an assessment of the effect of cracks in bolts on the distribution of stress along the bolt thread. Only cracks in the first thread root above the loaded face of the nut were considered in the photoelastic tests. The stress intensity factors of the cracks were found from the models and compared well with those predicted by the empirical formula derived by James and Mills (1988). The existence of a crack in a bolt was shown to cause a shift in the stress concentration factor away from the loaded face by an amount that was proportional to the depth of the crack. Tests were also performed to determine the changes that occur in the shape of fatigue cracks in bolts and to investigate the possibility of secondary cracking occurring. It was concluded that the shape of fatigue cracks depends upon the mean stress at which the bolt is tested. High mean stresses caused crescent shaped cracks to develop, the crescent shape becoming less marked at lower mean stresses, almost to the extent of becoming straight-edged. Secondary cracking was found to occur although not necessarily at the second thread root.


Taking SmarTeam as the research platform and taking engine product as example,the engine product data management model based on object-oriented technology is investigated in detail in this paper as well as its establishment technology.The Architecture of engine product data management system is established.Using the developing technology of SmarTeam,the function of list management is developed.


Summary form only given. Solitons are a fairly general nonlinear phenomena, appearing in very many nonlinear wave systems in nature. Very often, the solitons of a given system are all self-similar to each other. In other words, there is a simple scaling relation for their size and intensity that maps all the solitons onto each other. This happens when the underlying equation describing the system does not have any natural length scale appearing in it, a good example is the cubic nonlinear Schrodinger equation (NLSE).


A numerical pattern synthesis and optimisation technique for shaped and low sidelobe beams adhering to desired array element excitations are described. The synthesis approach is a modification of the Woodward synthesis method with an additional sidelobe minimisation, and the final element excitation optimisation is based on array polynome complex root swapping and genetic algorithms. These methods have been applied to an equispaced linear planar array. Results of the synthesis and genetic algorithms are presented.


To the Editor:

We read with interest the article by Jaeger et al1 published in the March issue of Stroke . In that article, tissue tension of oxygen (PtiO2) has been used as a surrogate marker of cerebral blood flow. After subarachnoid hemorrhage, in some patients a correlation (measured as the moving linear correlation coefficient, ORx) was found between changes in cerebral perfusion pressure (CPP) and corresponding changes in PtiO2, whereas in others this correlation was not detected. The absence of correlation was interpreted as a sign of preserved autoregulation, because a constant "flow" was …


It is an important goal to get larger contact area between armature and rails in the design and operation of railguns. However, oversize contact area may not be so necessary. Most of the current in the railgun will only flow in part of the contact area even the whole flank surface of the armature contacts the rails. So if part of the armature flank surface does not contact the rails, the maximum value of the current density remains almost the same as that with the whole surface contact. It is addressed in this paper what size is large enough from the view of current distribution and the maximum current density. Calculations are also done to analyze the factors affecting the size. Generally, 20% of the armature flank surface can be regarded as the large enough size of the contact area for the certain structure of railgun analyzed in this paper.


Food quality and safety are of paramount importance to the palm oil industry. The aim of this research was to develop a sustainable and in situ method to improve the quality of crude palm oil (CPO) using an aerobic-liquor generated in a palm oil mill. Compared to non-treated CPO, the aerobic-liquor treatment could produce CPO with higher hydrolytic and oxidative stability, as well as lower contaminant content. After refining, the palm oil produced has an improved quality and it performed better in deep-frying. The method was subsequently scaled-up and was found to be feasible for industry application.


Abstract : A MW class free electron laser capable of delivering energy at the speed of light can improve ASCM defensive capability for Navy ships. Many design challenges must be overcome to make such a weapon possible. One such challenge is to maintain the power density on laser cavity mirrors at acceptable levels. The use of a short Rayleigh length to increase beam spot size at the mirror is studied as a possible solution to this problem. In this thesis, it is shown that by using a short Rayleigh length FEL, power densities at the mirrors are significantly reduced without causing a noticeable reduction in performance. For a short Rayleigh length FEL, the resonator cavity is sensitive to misalignment and vibration. The effect of mirror tilt due to vibrations is explored and the results show that as mirror tilt increases, FEL efficiency does decreases. However, a mirror tilt several orders of magnitude greater than currently achievable active alignment tolerances is required before the FEL efficiency is noticeably affected. In this thesis, it is shown that mirror tilt within achievable tolerance limits will not adversely affect the performance of a FEL.


Recent VLBA and VLA observations indicate the possibility of a circumnuclear disc or torus of HI in detected in absorption in NGC 3894. Strong absorption lines are detected toward both the aproaching and receding jets. Absorption profiles integrated over six regions across the source are shown. At lease two velocity components are present in all lines of sight except toward the southeast. The parameters are obtained from these fits(Peck and Taylor,1998,Ap.J.,502,L23)~We use the bending model to explain the four prominent absorption features.


The cellular radioresponse is regulated by constitutively expressed proteins and by new gene expression. We have previously shown that radiation induces changes in gene expression primarily via translational control. Regulation of gene translation largely occurs at the initiation stage, and many factors that regulate initiation impact the eukaryotic translation initiation factor 4F (eIF4F) complex. eIF4F is comprised of the cap-binding protein eIF4E, the RNA helicase eIF4A, and the scaffold protein eIF4G. Because eIF4A is considered to regulate the translation of mRNAs involved in cell survival and proliferation, we investigated it as a target for tumor cell radiosensitization. Knockdown of eIF4A1 in the U251 glioblastoma and the HeLa cervical carcinoma cell lines resulted in a decrease in translational efficiency as determined by polysome profiling and an increase in cellular radiosensitivity as determined by clonogenic survival analysis. There was also an increase in γH2AX foci remaining at 24h after irradiation, consistent with an inhibition of DNA double strand break repair. These results suggest that eIF4A serves as a determinant of cellular radiosensitivity. As an additional approach to inhibiting eIF4A, we utilized the rocaglate hydroxamate (-)-SDS-1-021, which prevents eIF4A inclusion into eIF4F. Treatment of U251, HeLa and PSN1 pancreatic carcinoma cells with 10 nM (-)-SDS-1-021 resulted in decreased translational efficiency, which was accompanied by a decrease in protein synthesis. Treatment of the tumor cell lines with (-)-SDS-1-021 immediately before radiation resulted in an increase in radiosensitivity as well as an increase in γH2AX foci remaining at 24h, similar to eIF4A1 knockdown. Importantly, whereas treatment of the normal human fibroblast cell line MRC9 with (-)-SDS-1-021 also inhibited translation and protein synthesis, there was no effect on radiosensitivity. To gain a better understanding of the mechanism of radiosensitization by (-)-SDS-1-021, RNAseq was performed using polysome-bound mRNAs isolated from U251 and MRC9 cells. Cells were treated with 10 nM (-)-SDS-1-021, immediately irradiated (2Gy), and then harvested six hours post-irradiation. In U251 cells treated with 2Gy alone, 192 genes were translationally upregulated. The upregulation of 160 of these genes was inhibited by (-)-SDS-1-021 in the combination treatment group. Similarly, in MRC9 cells, 322 genes were translationally upregulated in response to radiation, and the upregulation of 173 of these was inhibited in the combination treatment group. By Ingenuity Pathway Analysis, the radiation-induced, (-)-SDS-1-021-sensitive genes in U251 were significantly enriched for proteins involved in DNA replication, recombination, and repair, which is in contrast to the MRC9 (-)-SDS-1-021 genes. Altogether, these findings suggest that eIF4A1 is a viable target for tumor radiosensitization. Citation Format: Stacey L. Lehman, Theresa Wechsler, Kayla R. Schwartz, Amy Wahba, Lauren E. Brown, John A. Porco, Jerry Pelletier, Kevin Camphausen, Philip J. Tofilon. Inhibition of the translation initiation factor eIF4A1 enhances tumor cell radiosensitivity [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 6507.


Objectives: The objectives of this study are to identify and compare the preferences of male and female undergraduate dental students on different aspects of teaching lectures and clinical courses in two major dental schools in Riyadh: the College of Dentistry of King Saud University (KSU) and Riyadh Elm University (REU). Materials and Methods: A questionnaire of three parts was formulated: Part 1 contained demographic data; Part 2 covered information about: the length and timing of lectures, schedule announcement, attendance, having materials before sessions, interactive sessions, and getting handouts and clinical demonstrations; and Part 3 covered preferences regarding logbooks, written assignments, quizzes, resources, team-based learning (TBL), and student feedback. The questionnaire was distributed to male and female undergraduate dental students in two dental schools in Riyadh. A stratified random sampling method was applied to collect a sample of 345 participants. Results: Among the participants, 159 were from KSU and 186 were from REU and 183 were male and 162 were female. About 74% of the dental students preferred the use of logbooks, and 40% preferred not to have written assignments. A total of 63% preferred using several resources, and REU students (72%) stated this preference more. More than half of the students (58%) agreed on having frequent quizzes. More REU (61%) than KSU students (38%) preferred (TBL). The majority (78%) preferred to take their feedback into consideration. Conclusions: This study illustrated that logbooks, writing assignment, and quizzes are learning styles that are still acceptable by dental students. Teachers should consider the feedback from the students when evaluating course outlines.


This review is focused on the impact of chemometrics for resolving data sets collected from investigations of the interactions of small molecules with biopolymers. These samples have been analyzed with various instrumental techniques, such as fluorescence, ultraviolet–visible spectroscopy, and voltammetry. The impact of two powerful and demonstrably useful multivariate methods for resolution of complex data—multivariate curve resolution–alternating least squares (MCR–ALS) and parallel factor analysis (PARAFAC)—is highlighted through analysis of applications involving the interactions of small molecules with the biopolymers, serum albumin, and deoxyribonucleic acid. The outcomes illustrated that significant information extracted by the chemometric methods was unattainable by simple, univariate data analysis. In addition, although the techniques used to collect data were confined to ultraviolet–visible spectroscopy, fluorescence spectroscopy, circular dichroism, and voltammetry, data profiles produced by other techniques may also be processed. Topics considered including binding sites and modes, cooperative and competitive small molecule binding, kinetics, and thermodynamics of ligand binding, and the folding and unfolding of biopolymers. Applications of the MCR–ALS and PARAFAC methods reviewed were primarily published between 2008 and 2013.


One of the goals of the Maastricht Treaty is to promote the harmonic, balanced and sustainable development of economic activities, and not-inflating economic growth. To achieve this item, the European Community worked out a collection of policies that, with special regards to culture, point out two main themes: cultural heritages as a tool to promote historic identities of lands ∙ cultural heritages as a tool to promote a new economic ∙ development Following this idea, the Doctorate Course on "Design and technologies for cultural heritages" promotes the training of new specialists able to integrate the various needs in design for the usage, valorization and management of cultural heritages.


We present a novel and compact six-mirror cavity configuration to combine four beams intracavity for energy scaling. A single beam output exceeding 453 mJ with 165 mus duration is obtained, with the combination efficiency of 90.7%.


The Ca2+ receptor, a member of the family 3 of G protein-coupled receptors (GPCR), responds not only to its primary physiological ligand Ca2+ but also to other di- and trivalent metals (Mg2+, Gd3+) and the organic polycations spermine and poly-l-Arginine. As has been found for other family 3 GPCRs, the large amino-terminal extracellular domain (ECD) of the Ca2+ receptor is the primary Ca2+ binding domain. To examine how the signal is propagated from the ECD to the seven-transmembrane core domain (7TM) we constructed a Ca2+receptor mutant (T903-Rhoc) lacking the entire ECD but containing the 7TM. We have found that this structure initiates signaling in human embryonic kidney (HEK) 293 cells stably expressing the construct. One or more cation recognition sites are also located within the 7TM. Not only Ca2+, but also several other Ca2+receptor-specific agonists, Mg2+, Gd3+, spermine, and poly-l-Arginine, can activate T903-Rhoc truncated receptor-initiated phosphoinositide hydrolysis in HEK 293 cells. The phenylalkylamine compound, NPS 568, identified as a positive allosteric modulator of the Ca2+ receptor can selectively potentiate the actions of Ca2+ and other polycationic agonists on the T903-Rhoc receptor. Similarly, organic polycations synergistically activate T903-Rhoc with di- and trivalent metals. Alanine substitution of all the acidic residues in the second extracellular loop of the T903-Rhoc receptor significantly impairs activation by metal ions and organic polycations in the presence of NPS 568 but not the synergistic activation of Ca2+ with poly-l-Arginine. These data indicate that although the ECD has been thought to be the main determinant for Ca2+recognition, the 7TM core of the Ca2+ receptor contains activating site(s) recognizing Ca2+ and Gd3+ as well as the allosteric modulators NPS 568 and organic polycations that may play important roles in the regulation of receptor activation.


Online purchasing is becoming increasingly common as a purchasing mode. At the onset of e-commerce it was thought that success was guaranteed merely by being present on the internet and offering low prices. Currently customer service has proved itself to be a key element for achieving good results in a website (Zeithaml, Parasuraman & Malhotra, 2002b). In this context, the study of commercial website quality has emerged as an area of strategic importance. As in traditional stores, service quality and customer satisfaction seem to play vital roles in the success and survival of Internet sites.


Purpose of review Update of key elements on enhanced recovery after thoracic anaesthesia and surgery. Recent findings Pathways to enhance recovery after thoracic surgery ('fast-track') aim to improve response to lung surgery, reduction of postoperative pulmonary complications, and restore patient's vital function. Uncomplicated recovery after lung surgery reduces morbidity, hospital stay, and costs. Video-assisted thoracoscopic surgery is a major part of enhanced recovery minimizing tissue injury and stress response. Maintaining patient's physiology throughout perioperative processes by optimized anaesthesiological management and effective pain control present a crucial role in improving outcome. Summary The concept of enhanced recovery ('fast-track') after thoracic surgery and anaesthesia was developed in recent years making allowance to the increased number of video-assisted parenchymal lung resections in managing primary lung cancer. Current studies promote the benefit in thoracic surgical patients, if an established departmental protocol-based algorithm is implemented.


To the Editor.— I have confronted a number of authoritarian regimes in medical journals. Oh, when did they begin the regime? I suspect physicians who "institute a therapeutic regime" are the same folk who deploy their "diagnostic armamentarium." The force of law and the presence of arms are perceived in the shadowy background of these multisyllabic terms. When did they begin the regime? Regime was not found in my medical dictionary but was present in the American College Dictionary , said to define a mode or system of rule or government. Regimen , from the Latin regere —to rule or to guide—was present in my Gould Medical Dictionary as "a systematic course or plan directed toward the improvement of health, the diagnosis of disease, or the investigation of biologic activities." Insidiously, the one term has been substituted for the other, perhaps on the simplistic ground that they look so much alike. Another


The variation of histomorphometric data in a bone biopsy cylinder of the iliac crest was determined in order to derive a rule of the sampling procedure in such a biopsy specimen. Measurements in different cylinders of a biopsy zone in the right and the left iliac crest were obtained in order to determine the magnitude of change necessary for the recognition of therapeutic or spontaneous alterations performing sequential biopsies.


The ground state energy of an atom is de ned to be lowest possible value of the energy Hamiltonian. This work describes an algorithm to obtain lower bounds for the ground state energy of atoms, together with its implementation. The results are within a few precent of the upper bounds given by Hartree{Fock's method.


Abstract : Maintenance of adequate oxygenation and prevention of hypoxemia are the primary goals for the battlefield casualty, but in military operations, oxygen is a limited resource to be conserved. A portable oxygen concentrator has the advantage of operating solely from electrical power and therefore is a never-exhausting supply of oxygen. Our previous bench work demonstrated that the pulsed dose setting of the concentrator can be used in concert with the ventilator to maximize oxygen delivery. We evaluated this ventilator/ concentrator system with closed loop control of oxygen output in a porcine model. The Zoll 731 portable ventilator and Sequal Saros portable oxygen concentrator were used for this study and were connected via a USB cable to allow communication. The ventilator was modified to allow closed loop control of oxygen based on the oxygen saturation (SpO2) via the integral pulse oximetry sensor. Twelve pigs were used for the evaluation. The animals were placed on a ventilator on 100 fraction of inspired oxygen (FIO2) and lung injury was induced by warmed saline lavage via the endotracheal tube until partial pressure of oxygen (PaO2)/FIO2 decreased to 100. The pigs were then placed on the ventilator/concentrator system and allowed to adjust the oxygen autonomously to determine if the target SpO2 could be maintained.


The formation, viscous evolution, and gravitational stability of protoplanetary disks are investigated. The formation process is parameterized by the angular velocity of the molecular cloud core omega, while the viscous evolution is parameterized by the viscosity parameter alpha in the disk; in this study we consider a range of (0.4-6) x 10(exp -14)/s for omega and from 10(exp -5) to 10(exp -1) for alpha. The axisymmetric gravitational stabilities of the disks are checked using Toomre's criterion. The resulting disk surface temperature distribution, (d log T(sub s)/d log R) approximately = -0.6 (R is the cylindrical radius), can be attributed to two heating sources: the viscous heating dominant in the inner disk region, and the accretion shock heating dominant in the outer disk region. This surface temperature distribution matches that observed in many disks around young stellar objects. During the infall stage, disks with alpha less than 10(exp -1.5) become gravitationally unstable independent of omega. The gravitational instabilities occur at radii ranging from 5 to 40 AU. The ratio of the disk mass to the central star mass ranges from 0.2 to 0.5 at the times of instability, about 4 x 10(exp -5) x (omega/10(exp -14)/s)(exp -0.67) yr. Most disks with low alpha and high omega become gravitationally unstable during their formation phase.


An anti-anaphylactic braided fabric is prepared from woven chain and latitude line, longitude line and filling yarn, or longitude line and latitude line, wherein, each longitude line and filling line has dual yarns, while the average aperture of braided fabric is not higher than 9 mum, thereby improving the anti-anaphylactic effect, improving service life and reducing cost.


According to contrast of surface moving deformation after excavating the second and the fourth coal seam in the west of the frist stope in Zhaizheng colliery,this passage analyzes the regularity of the influence of repeated excavation on surface moving deformation,and puts forward countermeasures and proposals.It is useful for the excavation of mining many coal seams in future


Experiment on species composition of rocky coastal protective forest was carried out in Sanmen and Ninghai county, Zhejiang province, and determination was made on tree growth.


Immunization of Macaca irus monkeys with purified soluble HL-A substances provokes both antispecies and anti-HL-A cytotoxins. By absorption with defibrinated human blood, HL-A reagents of high titre can be prepared in good yields based on initial cytotoxicity. The absorbed sera have a very high correlation with HL-A specificity. When a monkey was immunized with an HL-A substance for which its peripheral lymphocytes typed positively, neither HL-A nor species cytotoxins were produced. A hypothesis is discussed to explain this finding in which it is proposed that a species determinant on the HL-A molecule represents a weaker immunological stimulus to another primate species than the HL-A determinant.


With the aim of addressing the impact of extractive protocols in molecular characterization of ceramic content, sixteen archaeological shards and waterproofing coatings of Roman amphorae were studied to compare the extractive capacities of protocols prevalently mentioned in wine amphorae analysis. A microwave-assisted protocol is developed in order to esterify grape-derivative markers from archaeological pitch and shard. Gas chromatography-mass spectrometry is used to highlight the great capacities of a two-step protocol that combines organic extraction with BF3-etherate complex butylation applied on archaeological shards. Instead, simultaneous alkaline fusion and direct-resin acid-catalyzed butylation are favored for the characterization of waterproofing material. The identification of tartaric acid, together with succinic, fumaric pyruvic and syringic acids provide valuable insights on the archaeological grape-derivative content, possibly wine. Diterpenic markers highlighted Pinus pitch and wood tar, originally used to waterproof the amphorae. Since markers are reliable tools in organic residue analyses, protocols exhibiting high extractive capacities are favored to avoid false conclusions drawn through the absence of markers.


Non-destructive inspection using ultrasonic sensors is widely utilized to guarantee the safety of large structures. However, there is the problem that it will take a very long time to complete. Therefore, it was decided to develop a sensor capable of testing a wide range of structures at a high inspection speed. The ultrasonic wave that the ultrasonic sensor can generate must be equally emitted in any direction and the ultrasonic wave returned from any direction be detected. To attain this objective, an electromagnetic acoustic transducer (EMAT) consisting of a circular-shaped magnet and an electric induction coil (EM) has been developed, because it is impossible to fabricate such a special ultrasonic sensor using a commercial-type ultrasonic sensor with a piezoelectric element, and it is convenient to automatically scan over the surface of the structure. First, the detail specifications of the new ultrasonic sensor have been determined by changing many of the parameters, for example, the impedance and the size of the EM coil, the size of the magnet, etc. The performance of the new sensor was then tested under different conditions. Based on the results of the experimental tests, it was demonstrated that the new sensor could generate ultrasonic waves in any direction and detect them from any direction. However, the performance was not high enough to apply the new sensor to a real structure. The new sensor has been improved to increase the performance by adding a new concept.


Ultraviolet multiphoton excitation with a picosecond laser pulse at the wavelength of no appreciable ground-state absorption has been used to excite benzene and alkylbenzenes homogeneously in the neat liquid state and to investigate their photophysical and photochemical primary processes by picosecond time-resolved transient absorption spectral measurements. The excimer formation processes in neat liquid benzenes excited by two-photon absorption of the 355-nm picosecond pulse from a Nd/sup 3 -/:YAG laser have been confirmed to proceed via ionization and recombination processes, and the lifetime of the ionized (ion pair) state has been determined to be 10-20 ps in neat benzene. 26 references, 4 figures, 4 tables.


Abstract 4598 There are few data on the use of maintenance Rituximab after auto-SCT for patients with B cell lymphoma of aggressive histology that are resistant to chemotherapy. From May 2005 to March 2010, 25 consecutive pts underwent auto-SCT for DLBCL resistant to chemotherapy at our center. Median age 43 year (7 – 69 yrs); 11 patients were male. Two pts were HIV positive. Initial staging was II-B in 6 patients, II-EB in 4 patients, III-B 8 patients and IV-B in 7 patients. Initial IPI score was low-intermediate (13% of the pts), high-intermediate (58%) and high (29%). Nine of the 25 pts had bulky disease and 8 had visceral or bone marrow lymphomatous involvement. The median time from diagnosis to auto-SCT was 21 months (13 – 48 m). Prior to auto-SCT, 44% of the patients received 2 chemotherapy regimens and 56% received more than 2. All pts had chemotherapy-sensitive disease to the their last chemotherapy regimen prior to auto-SCT, with 80% and 20% of the pts achieving complete and partial remission prior to transplant, respectively. Sixteen out of 25 pts received Rituximab prior to auto-SCT; of those, 5 received Rituximab in the first line chemotherapy and 11 received it as part of the rescue chemotherapy regimens. The protocol was approved by our institutional review board and informed consent was obtained from each pt and or their guardians. Conditioning regimen consisted of Cyclophosphamide 1500 mg/m2 (D-6 to D-3), Etoposide 400 mg/m2 (D-6 to D-3) and Carmustin 150 mg/m2 (D-6 to D-4). The median CD34+ cells/kg infused was 2.9 × 106/Kg (1.9 - 8.5×106). All pts received G-CSF 10 micrograms/Kg/day SC from day +1 until neutrophil engraftment. Median time to neutrophil engraftment (ANC >500/mm3) was 8 days (5 – 17 d). Median time to platelet recover (>20,000/mm3) was 13 days (7 – 29 d). Transplant related mortality at day +100 was one in 25 pts (4%); this pt died due to multi-drug resistant Pseudomonas infection on day +17. Rituximab 375mg/m2 weekly for 4 weeks was administered as maintenance for a total of 4 cycles (16 doses); the cycles started on days +120, +240, +360 and +480 after auto-SCT. Twelve pts developed mild infusion reaction (tremor and rash). The hematological toxicity was low; grade II neutropenia occurred in 9 out of 25 pts. The neutropenic only occurred after the forth dose of the cycle with a median duration of 5 days (2 - 13). All pts received Bactrim and Acyclovir prophylaxis for one year after the auto-SCT. There were no viral infectious complications. Four of the 25 pts died (16%); one due to Pseudomonas infection; 3 due to relapsed disease which occurred at 6, 9 and 19 months after the transplant. Overall disease free survival was 75% with a median follow up of 31 months (6 - 55 mo). Of the five pts with refractory disease who had received Rituximab at some point prior to transplant, 2 pts relapsed and died due to refractory Lymphoma after the transplant, but 03 are alive in CR (9, 13, 21 months). Our data suggests that the administration of Rituximab as maintenance after auto-SCT for pts with DLBCL is well tolerated and it may decrease the incidence of relapse. Randomized studies are warranted to confirm the benefit of Rituximab as maintenance in the post auto-SCT setting to decrease relapse rate. Disclosures: No relevant conflicts of interest to declare.


To increase machining efficiency, in addition to determining the temperature distribution on the tool surface, it is also necessary to determine the internal temperature distribution. The existing methods for determining the cutting tool temperature distribution and temperature field measurement have significant disadvantages, which limit their applicability and accuracy. The purpose of this study is to develop and test a novel cutting tool temperature field measurement method. The method involves recording the cutting tool thermal expansion fields by laser interferometry and calculating the tool material temperatures with its coefficient of thermal expansion (CTE). Compared with the methods employing infrared thermometry, the method developed in the present study has a higher spatial resolution and a lower achievable field of view due to its usage of light in the visible region. In addition, since the oxidation film has a higher reflection coefficient for visible light, the present method is less sensitive to the thin-film interference on an oxidized tool surface than those using infrared thermometry, eliminating the false shift of the measured temperature. Moreover, by utilizing cheaper optical components and equipment for interference fringe pattern registration, this method is more affordable. Unlike the emissivity coefficient in infrared thermometry, CTE is independent of changes in the surface quality and can be measured with high accuracy by modern dilatometry. Therefore, the developed method, which employs CTE to calculate the temperature, has a higher reliability. In the present study, the efficiency of this method is tested by the orthogonal turning of difficult-to-cut martensitic heat-treated steel with a cemented tungsten carbide tool. Through the experiment, the temperature distributions along the rake face and flank of the tool, as well as the temperature field inside the tool, were obtained. The results can improve the temperature field measurement in machining cutting tools.


In order to study the effects of different polyunsaturated fatty acids (PUFA) ratios on the immune responses of laying hens, one hundred and sixty eight thirty week old laying hens were randomly assigned to ten diets containing five ratios (1∶1, 1∶4, 1∶8, 1∶16, 1∶32) n 3/n 6 PUFA supplemented with 30 or 300 mg/kg VE. Laying hens were injected with BSA at week 5 and week 7, antibody titers were measured at 10 d after primary and secondary challenge respectively. Concanavalin (ConA) and lipopolysaccharide (LPS) stimulated proliferation of lymphocyte in blood and IgY concentration of egg yolk were assessed at week 5 and week 10 respectively. At week 9, plasma IgG concentration was determined at 6 h, 12 h and 24 h after LPS was injected. Results demonstrated that as the ratios of n 3/n 6 decreased, anti BSA titers decreased significantly (P0.05), egg yolk IgY concentration also decreased but unsignificantly (P0.05). Ratios of n 3/n 6 and VE added level in diets can also affect IgG concentration of plasma. As the ratios of n 3/n 6 decreased, lymphocyte proliferation of blood to ConA increased significantly (P0.05) at week 10. N 3 to n 6 ratio at 1∶1 to 1∶8 can increase the immune responses of laying hens.


Near-infrared Characterization of the Atmospheres of Alien Worlds Bryce Croll Doctor of Philosophy Graduate Department of Astronomy and Astrophysics University of Toronto 2011 In this thesis I present near-infrared detections of the thermal emission of a number of hot Jupiters and likely transit depth differences from different wavelength observations of a super-Earth. I have pioneered "Staring Mode" using the Wide-field Infrared Camera on the Canada-France-Hawaii Telescope to achieve the most accurate photometry to-date in the nearinfrared from the ground. I also discuss avenues that should allow one to achieve even more accurate photometry in the future. Using WIRCam on CFHT my collaborators and I have detected the thermal emission of the following hot Jupiters: TrES-2b and TrES-3b in Ks-band, WASP-12b in the J, H & Ks-bands, and WASP-3b in the Ks-band on two occasions. Nearinfrared detections of the thermal emission of hot Jupiters are important, because the majority of these planets' blackbodies peak in this wavelength range; near-infrared detections allow us to obtain the most model-independent constraints on these planets' atmospheric characteristics, their temperature-pressure profiles with depth and an estimate of their bolometric luminosities. With these detections we are able to answer such questions as: how efficiently these planets redistribute heat to their nightsides, if they're being inflated by tidal heating, whether there's any evidence that one of these planets is precessing, and whether another experiences extreme weather and violent storms? My collaborators and I have also observed several transits of the super-Earth GJ 1214b. We find a deeper transit depth in one of our near-infrared bands than the other. This is likely indicative of a spectral absorption feature. For the differences in the transit depth to be as large as we observed, the atmosphere of GJ 1214b must have a large scale height, low mean molecular weight and thus have a hydrogen/helium dominated atmosphere. Given that other researchers have not found similar transit depth differences, we also discuss the most likely atmospheric


The present paper relates to a process for obtaining SE( sugar fatty acid esters)from methyl ester of aliphatic acid, which is prepared by the reaction between a higher fatty acid and a methyl alcohol, and sucrose in the presence of catalyst. In this process a few surfactants is utilized as promoter, instead of using any solvent as reaction medium. The quality indexes of product accord with GB10617 - 89.


Clinical examination remains the gold standard in the diagnosis of a cyclodialysis cleft. This could be challenging especially in the presence of folds in Descemet's membrane, hyphema, corneal edema, peripheral anterior synechiae or a shallow anterior chamber.1.


Purpose: To introduce a simple and practical method for detecting vitrectomy infusion line position in a hazy media. Methods: The position of the infusion cannula was evaluated before and during vitrectomy in 17 eyes of 17 patients with hazy media. This procedure was performed by using the light pipe inserted partially into the cannula and determining the color of transmitted light into the vitreous cavity. Dark red or brownish color was considered as suprachoroidal placement and bright whitish color as the correct position of the cannula tip. Results: In 13 patients, the position of the cannula was considered as a precise position by using the aforementioned method at the beginning of the operation, and vitrectomy was performed without any infusion line-related complications. In two cases, the incorrect placement of the infusion cannula was confirmed with this technique, and the cannula was reinserted and repositioned. In two cases, secondary slippage of the cannula in suprachoroidal space was detected by using this method during vitrectomy, and another cannula was tried in another position. Conclusion: Using the color of light pipe inserted partially into the cannula is a safe and simple method for evaluating the position of the infusion line in the eye.


Technical advances in diagnostic capabilities have given many physicians, including neurologists, a false sense of security in diagnosing multiple sclerosis (MS). The increasing dependency upon the results of these electrophysiological, immunological and tissue-imaging procedures has made doctors pay less attention to the history and the neurological examination. Although some enthusiasts claim the nuclear magnetic resonance (NMR) scan will render the clinical neurologist obsolete, the actual facts are quite different. Most if not all the specialized procedures that have been introduced are not specific for MS, many of them require careful interpretation, and some of them, despite their popularity, are irrelevant. The unfortunate result is that the number of patients with what should be called pseudo-MS appears to be. growing. Another area closely related to diagnosis is the question of introducing new and experimental therapeutic regimens. These must be tried only on MS patients whose diagnosis meets certain criteria, and very specific types of MS, known only from the history. Before initiating treatment both diagnostic criteria and nomenclatural definitions must be carefully considered. Conditions that are similar in one aspect or another to MS that create problems both in differential diagnosis and prognostication are a final consideration. Among those, of course, is hysteria. Almost a century ago, Farquhar Buzzard stated that "in its infancy the name given to M S is hysteria." The relationship of hysteria to MS is so well known that it will not be dealt with here. Among the other problems of the differential diagnosis is acute disseminated encephalomyelitis, more recently called disseminated vasc~lomyelinopathy.**~ When this occurs after a benign, unrecognized or subclinical infection it is hard to distinguish from the first attack of MS. Acute transverse myelitis, chronic progressive myelopathy, optic or retrobulbar neuritis and the spinocerebellar degenerations are among the classical differential diagnostic dilemmas.


This paper presents a 50Gbps half rate SerDes transmitter with automatic serializing time window search. By implementing a serializing time window search loop, the serializing timing is guaranteed and circuits running at highest speed such as latches for retiming and clock tree buffers for delay matching are eliminated. Fabricated in 65nm CMOS technology, the transmitter running at 50Gbps consumes only 75mW power under 1.2V power supply. The total jitter of 50Gbps eye diagram is 9.8ps for 1e-12 BER.


Revised! EENY-203, a 3-page illustrated fact sheet by H.V. Weems, Jr., is part of the Featured Creatures collection. It describes this species of fruit fly that attacks cherries and causes wormy fruits — synonyms, distribution, identification, life history and habits, and hosts. Includes references. Published by the UF Department of Entomology and Nematology, August 2009.
EENY-203/IN360: Cherry Fruit Fly, Rhagoletis cingulata (Loew) (Insecta: Diptera: Tephritidae) (ufl.edu)


Background: Disparities in cancer defined by race, age, or gender are well established. However, demographic metrics are surrogates for the complex contributions of genotypes, exposures, health care, socioeconomic and sociocultural environment, and many other factors. Macroenvironmental factors represent novel surrogates for exposures, lifestyle, and other factors that are difficult to measure but might influence cancer outcomes. Methods: We applied a "multilevel molecular epidemiology" approach using a prospective cohort of 444 White prostate cancer cases who underwent prostatectomy and were followed until biochemical failure (BF) or censoring without BF. We applied Cox regression models to test for joint effects of 86 genome-wide association study–identified genotypes and macroenvironment contextual effects after geocoding all cases to their residential census tracts. All analyses were adjusted for age at diagnosis and tumor aggressiveness. Results: Residents living in census tracts with a high proportion of older single heads of household, high rates of vacant housing, or high unemployment had shorter time until BF postsurgery after adjustment for patient age and tumor aggressiveness. After correction for multiple testing, genotypes alone did not predict time to BF, but interactions predicting time to BF were observed for MSMB (rs10993994) and percentage of older single heads of households (P = 0.0004), and for HNF1B/TCF2 (rs4430796) and census tract per capita income (P = 0.0002). Conclusions: The context-specific macroenvironmental effects of genotype might improve the ability to identify groups that might experience poor prostate cancer outcomes. Impact: Risk estimation and clinical translation of genotype information might require an understanding of both individual- and macroenvironment-level context. Cancer Epidemiol Biomarkers Prev; 19(9); 2115–23. ©2010 AACR.


Choroterpes gregoryi new species (type locality: Maquenco, Costa Rica) and Choroterpes mairena new species (type locality: Cuajiniquil, Costa Rica) (Ephemeroptera: Leptophlebiidae: Atalophlebiinae) are described from imagos and nymphs. Both species occur along the west coast of Costa Rica in streams on or near the Nicoya Complex. Choroterpes mairena is adapted to living in temporary streams with long dry seasons, while Choroterpes gregoryi is found in permanent streams. Both species occur in pools with extensive leaf packs.