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Sharing with other charities and neighborhood churches we gave the aid away to grateful families quickly. Charities such as Matt 25 joined in to pass out aid as fast as possible.
Matt 25 joined arms with us seeing such a great need. We appreciate their help!
In a crisis time families need aid quickly. They are standing in chaos often overwhelmed at the tasks before them with little outside help. MAH and our partners understand this and reach out as fast as possible to put help, encouragement and supplies in their hands.
"A Thank You gift from Matthew 253540 Ministry's to those who help Feed The Homeless daily ! Mom's Against Hunger, this gift wouldn't have been possible without your help/donation. Thank You!"

subset: commoncrawl


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A new campaign aimed at raising awareness of wildlife crime in East Yorkshire is encouraging residents to report such incidents to the police.
Humberside Police with charities Crime stoppers and World Animal Protection Wildlife, are working together to stop cruelty against animals, which have come under attack the form of trapping, hare coursing and illegal hunting.
A police spokesperson said: "Wildlife crime is diverse and happens everywhere, including cities. Hare coursing is just one form of illegal poaching that takes place all over the UK but specifically affects the Humberside Police area.
"Trapped and terrified: hare coursing involves a wild animal brutally killed for money & entertainment."
The blood sport involves greyhounds chase down hairs andin 2004, The Hunting Act made hare coursing illegal and anyone convicted of the offence can be fined up to £5,000 by a Magistrates' Court.
However the force is not only targeting hare coarsers, but also deer and badger poachers who often use 4x4 vehicles, dogs and firearms when for animal cruelty.
"Suspicious looking road kill or the discovery of bait, traps and snares indicate poaching," the spokesperson continued.
Laws are also in place to protect Britain's avian life and Humberside Police take a tough stance against those who may compromise birds' well bring.
"Walking or working in a known nesting area, heather burning or use of machinery is bird disturbance - it is a wildlife crime" The police spokesperson said.
The law also states that is illegal to kill, steal or injure any wild bird,take or damage the nest of any wild bird whilst in use or being built.
Egg collecting can also carry a serious penalty and the RSPB said: "Anyone that chooses to be in possession of eggs is obliged to show, on a balance of probabilities, that their possession is lawful.
"For persons found guilty of any of these offences, Magistrates have the power to impose maximum sentences of £5,000 fine and/or six month's imprisonment per egg."
Bats are in decline in the UK and there are only 16 species left and some are very rare. The law protecting bats is similar to that which protects birds.
Harming a bat, damaging or destroying a roost can carry a £5,000 penalty and up to six months in prison.
For more information on wildlife crime and how to report it, visit the National Wildlife Crime Unit's website at www.nwcu.police.uk.
Alternatively call Crime Stoppers anoymously on 0800 555 111.


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How to show a Google map in your Phonegap app using Google Map api V3, and what whitelist urls to add to your project. This post expect you know how to set up a new Phonegap project.
1. Start by adding a reference to Google maps api in index.html
Then add a div that will contain the map. Choose an id like "map_canvas". That id will be used to add our map from our javascript later on.
##2. Create a new javascript file called googlemap.js in the www folder and add the following content
and add a reference to it in index.html
the mapOptions variable contains information about zoomlevel, where the center of the map is and what kind of map we want to show. And the line containing the map variable uses getElementById to get our map_canvas and adding the map.
3. Whitelisting google urls
Now we must add the following urls to our Cordova.plist under externalHosts if using Xcode:
4. Showing the map
To show the map we must run the initialize function in googlemap.js. Since we are using the example index.html from phonegap we add these lines to the onDeviceReady function in index.html
Now run the app and you should se a map over Australia.
5. Adding markers
To add markers to our map we use the LatLng and Marker object from Google API. Edit the initialize function in googlemap.js to look like this:
and add the following function, called addMarkersToMap:
Here we added a function called addMarkersToMap and called it from the initialize function. What it's doing is adding two markers on our map at the given latitude and longitude. And when we create a new marker object, like markerOne, we give the object the position and which map we want to add the marker to.
But if we run the app now we only see one marker. Let's fix that.
6. Zooming out the map to show all markers
to zoom out the map without knowing which zoomlevel to use we are going to use the LatLngBounds object from the Google Map API.
Start off by adding the following line first in the addMarkersToMap function:
and before the closing tag of the function add these lines:
The addMarkersToMap function now looks like this:
Now we're done, run the app and the map now zooms out so you can see the marker which we added in Sweden.
I've created an example application of this and pushed it to a repository on Github, have a look at it if you want to see the code.


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Earlier last month, I was invited to Fusion Kitchen's event – A Taste of Pakistan. Fusion Kitchen is a start-up social venture that helps recent immigrant women develop their transferable skill sets, work experience, and self-confidence through teaching cooking classes focused on dishes specific to their cultures. Sonam Swarup & Chantelle Buffie from Simon Fraser University started up this project.
Sonam and Chantelle started Fusion Kitchen because they were both passionate about helping this particular demographic of women overcome the barriers they face to get in employment in Canada. There's so many opportunities in Canada, and these women have so much to offer, but because of a combination of things, employers don't tend to give them that "first chance" in the Canadian workforce. Having mothers both from ethnic background who came to Canada at a much older age also made the issue resonate more personally with them. Fusion Kitchen combines their love for community giving, culture, food, and travel into one.
During this event, our special guest – Shahnaz Afsar led us through the evening. She emigrated from Pakistan to Canada and has a background in the education sector. We have 3 hours to work in groups to create a whole meal.
As we arrived, we were greeted by Shanaz and given traditional Pakistan appetizers and juice. All the other attendees were able to mingle and have a snack before getting down and dirty.
Before we got into the cooking, we were given a quick lecture on Pakistani culture and quick steps for the recipes we were going to create. The audience is able to ask questions anytime.
All the ingredients were nicely laid out for us and it was a joy using spices and ingredients that were foreign to me.
Everyone was split up into groups. It's a great chance to meet new people in the community. Plus team building is always so much fun! At the end of the class, the best group wins a prize!
We all had the recipes in hand and we begun prepping all the ingredients. I loved all the vibrant colors and smells.
You really gotta get your hands down and dirty when prepping.
One of the bes tricks I've learned is how to separate the yolk from its egg. You crack the top of the egg so there is a small hole. Then, you can easily pour the egg white out without getting the yolk or egg-shell in it.
You make everything from start to finish. These were our Lentils and Mint Kebabs!
There was a cooking area on the other side of the kitchen. I spent much of my time prepping, so I didn't spend much time here. Our group left most of the cooking to Colleen.
After a while, everyone's prep area would become a mess. hahaha. Sometimes the ingredients can look similar. There were times when we were just tossing things around trying to look for something. A great thing about a shared kitchen space is that everyone is willing to help each other out.
With all the hard work, we were able to enjoy the meal together as a class!! The food we cooked accommodated vegetarian as well.
Lentils and Mint Kebabs
Potatoes with Cumin
Squash Sabzi
Chicken Makhni (Spinach) was my favorite. I don't know if it was the recipe or the awesome cooking abilities of the class, but it was so good. It was so good that I am even considering cooking it at home. (Me cooking?! I know right?)
Peas Pulao
You can grab as little or as much as you want…but keeping in mind others appetites too. It was really good!
My group didn't win the prize for the best group, but it was very full to compete. The winning group got the ingredients for one of the recipes.
It was really fun and I had a great time! We all got a booklet at the end of the class that summarized the event and included all the recipes! I would suggest this cooking class to anyone who want to try to cook new types of cuisines, while meeting new people!
Check out their next cooking class: http://www.thefusionkitchen.com/our-next-cooking-class/


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This thanksgiving got me thinking about what I'm thankful for this year and I thought I might share them with your readers and hopefully we learn from you as well.
1) I'm thankful for my family and my children for giving me constant love, being bright, and respectful.
2) I'm thankful for my friends - the old ones who have stuck around, and the new ones who keep blowing my mind, and to my generous and kind friends who bought me "GORED GORDED, KITFO, SHIRO, and invited me for drinks.
3) I am thankful for my friends who empathized with my issues and concerns and stood their ground on principle. Friends:
· Who live their life in an honest and truthful way
· Who share their gifts of honesty and integrity with others.
· And friends who always have fun with their friends and community without compromising their values.
4) I'm thankful for the web (CNN, Aiga, Walta, Tigrai online, Dekialula, BBC, and many notable sites for giving me an amazing outlet and the ability to give me updated news bond me with people all over the world. People like you.
5) I am thankful for the teachers who guided and educated my children.
6) I am thankful for our current and fallen heroes for paving the way so I am reunite with my family without the fear of being tortured and my body will be dragged in the middle of the capital for display.
7) I am thankful for our priest for being our shepherd, teach us so much about Church and its importance and his great ways of explaining God's word, and demands "NOTHING" in return.
8) I am thankful for the voters (that includes me) who assisted in making, the bright and feisty Nancy Pelosi The Speaker Of The House.
9) I am thankful for being alive.
10) I am thankful for having a job. (You know what happens if you don't have a job: -Let's just it would not be pleasant.
11) And most of all, this thanksgiving, I'm thankful I'm not a turkey.
HOW ABOUT YOU-- WHAT ARE THANKFUL FOR THIS THANKS GIVING SEASON. (Please share)
Abel Ghirmai- The Emerald City, WA


text:
The Facebook Messenger has undergone a lot of changes since the past few months. For instance, the Messenger 4 had got rid of the clutter by going from nine tabs to just four and simplified the interface so it was easier to send a photo or begin a video call. The social giant had also introduced a dark mode, threaded replies and a ten-minute unsend window. During the F8 2019, the annual developer conference of Facebook, the company announced there would be even more changes coming to the Messenger in 2019.
Samsung's HU8550 Series is currently available in sizes ranging from 50 to 75 inches, with an 85-incher coming this month.
The Ultra High Definition (UHD) TV market will be heating up this summer. Samsung Electronics has announced several new TV models, which will expand the company's offering to six UHD series with sizes ranging from 40 to 110 inches.
The latest and largest of the new additions is the 85-inch UN85HU8550. Promising an extra-large, eye-popping image, this member of the flat-panel HU8550 Series has a 3840x2160 resolution, as well as UHD Dimming and Precision Black features. UHD Dimming can scan the number of zones in the image and adjust brightness accordingly, while Precision Black dims LEDs behind the darkest area of the picture for a better contrast and darker black levels. Other features include Wide Color Enhancer Plus technology, Clear Motion Rate 1200 for smooth action, four HDMI inputs and three USB ports.
This 85-incher also has a quad-core processor, which will make whipping through all of the set's Smart TV features a breeze. Besides access to a slew of web-based streaming services, Samsung's Smart TV platform includes the recently released Smart Hub, which can organize all of your entertainment into five panels right on the home screen. It also has the S Recommendation feature for discovering new content based on your preferences and what's trending. And just in case you still find it overwhelming to navigate through all of the features, this set has voice interaction, which allows you to speak commands for everything from web surfing to powering the TV to "turn off."
Samsung will offer the 85-incher later this month, with a $9,999.99 price tag. However, the company is currently selling the HU8550 in 50- ($2,499.99), 55- ($2,999.99), 60- ($3,499.99), 65- ($3,999.99) and 75-inch ($5,999.99) screen sizes.
Samsung also plans to release the curved HU7250 Series. That curved design boasts a more immersive viewing experience, a wider field of view with a panoramic effect, and a better viewing angle from any seat in the house. The HU7250 Series includes UHD Dimming and upconverting of SD, HD and full HD content to near UHD picture quality. It also has Samsung's own Quad Screen Multi-Link feature, which allows users to turn one screen into four. Other features include the quad-core processor and the Smart TV platform with Smart Hub. The 55-inch model ($2,199.99) and a 65-incher ($3,299.99) will start shipping sometime in August.
Last in the new UHD TV lineup is the HU6950 Series. This collection of flat UHD TV sets has the quad-core processor, the Smart TV options with Smart Hub, web browsing, and the Quad Screen Multi-link feature. Other features include Clear Motion Rate 240 technology, UHD Dimming, four HDMI inputs, and three USB ports. Available this month, the HU6950 Series includes a 40-inch model ($999.99), a 50-inch set ($1,499.99), and a 55-incher ($1,999.99).
"As the UHD TV market leader, we're seeing excellent category growth and adoption among consumers who are looking for the highest resolution and best-in-class picture quality Samsung UHD TVs offer," said Joe Stinziano, executive VP of Samsung Electronics America. "We're excited to introduce another super-sized model and two entirely new series to our UHD TV family. Whether it's a flat or curved UHD TV, Samsung continues to provide consumers the broadest selection of UHD TVs for any home."
All of Samsung's UHD TVs also include support for HEVC, HDMI 2.0, MHL 3.0 and HDCP 2.2, as well as future-proofing options via the Samsung UHD Evolution Kit.


text:
Spokeo is one of the larger people search sites. The expose primarily public records and publicly available information.
How to Remove Your Information from Spokeo
Locate the individual listing to remove (for name listings, please select the state, city, then exact profile match).
Copy the URL (the URL can be found on the top of your browser and should look something like "http://www.spokeo.com/search?q=Smith%20Sample#Sample:1219812367″).
Go to Spokeo's opt out page.
Paste the URL.
Provide your email address (this acts as a verification process for the confirmation to be sent to your Inbox) and solve the captcha.
Check your Inbox for the confirmation email, and click on the link on the bottom to complete the removal process.
The directory listing will become flagged and will be removed within 1 business day.


text:
- Research
- Open Access
Lack of association among TNF-α gene expression, -308 polymorphism (G > A) and virulence markers of Helicobacter pylori
- Luanna Munhoz Zabaglia1,
- Mariane Avante Ferraz1,
- Weendelly Nayara Pereira1,
- Wilson Aparecido Orcini1,
- Roger Willian de Labio2,
- Agostinho Caleman Neto2,
- Fernanda Wisnieski3,
- Juliana Garcia de Oliveira1,
- Marilia de Arruda Cardoso Smith3,
- Spencer Luiz Marques Payão1, 2 and
- Lucas Trevizani Rasmussen1Email author
© Zabaglia et al. 2015
- Received: 30 June 2015
- Accepted: 21 December 2015
- Published: 30 December 2015
Tumor necrosis factor plays a critical role in the pathogenesis of gastric diseases such as gastric cancer, and an abnormal inflammatory response has frequently been observed in dyspeptic patients. Helicobacter pylori infection can induce a gastric mucosal inflammatory response that may be influenced by -308 (G > A) polymorphisms and gene expression of the TNF-α gene.
One hundred and thirty-four gastric biopsy samples were collected from patients of both genders (61♂ and 73♀, mean age 40.3 ± 24.2 years) with gastric symptoms. The -308 (G > A) polymorphism of TNF-α was characterized using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The expression level was measured using real-time PCR, and relative quantification (RQ) was calculated using the comparative CT method (2-ΔΔCT).
The analysis revealed an increase in TNF-α gene expression in patients with gastritis; on the other hand, no statistical differences were observed in patients with gastric cancer. In addition, no association was found among -308 polymorphism genotypes, virulence markers, or TNF-α gene expression.
Helicobacter pylori induces a large increase in TNF-α expression in patients with gastritis, regardless of tissue inflammation, but after the tissue becomes neoplastic, the presence of bacteria did not influence expression. These results suggest that the TNF-α pathway may play an important role in the progression from gastritis to gastric cancer
- H. pylori
- TNF-α
- Gene expression
- Gastric cancer
- cagA
Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes more than half of the world population, causing chronic infection. It comprises a major risk factor for gastric cancer (GC), which is the fourth most commonly diagnosed cancer and the second most deadly one, with over 750,000 new cases annually worldwide [1, 2].
Several factors are correlated with the severity of clinical outcomes. These factors include the virulence markers of H. pylori, such as the genes cagA, vacA and dupA, and host genetic factors. However, bacterial factors or host genetic factors alone are not sufficient to explain why so few individuals harboring H. pylori develop gastric disease [3, 4].
Evidence suggests that the main pathophysiological event in the H. pylori infection of gastric mucosa is the induction of a gastric mucosal inflammatory response. This reaction is induced by the contact of H. pylori with gastric cells, and is followed by neutrophil and mononuclear cell activation and the transcription and synthesis of pro-inflammatory and anti-inflammatory cytokines [4, 5].
Tumor necrosis factor alpha (TNF-α) is a very important multifunctional pro-inflammatory cytokine. It provides a rapid form of host defense against infection by gram-negative bacteria. It is produced by activated monocytes and macrophages, which play a key role in inflammatory response [6]. However, this cytokine is also associated with gastric acid inhibition and paracrine effects, both of which may increase the risk of developing gastric cancers [7, 8].
Several polymorphisms in the promoter region of the TNF-α gene have been associated with a variety of inflammatory diseases and cancer [9, 10]. TNF-α-308 G > A (rs1800620), one of the most frequently studied polymorphisms on this gene, seems to have an influence on transcriptional activities and may contribute to the development of gastric disease [11]. Furthermore, previous studies showed that H. pylori virulence markers, such as cagA, vacA, and dupA genes, play important roles in gastric mucosal inflammation and injury through activated inflammatory cell infiltration [12–14].
CagA-cytotoxin is a virulence factor that has been well established as being associated with the development of peptic ulceration or gastric adenocarcinoma. This protein is translocated into the epithelial cytosol, thus causing changes that favor the persistence of the bacterium, but which also lead to changes in gastric cells without the direct adherence of bacteria in the stomach [15].
Another important virulence marker is vacuolating cytotoxin A (vacA), which encodes the secreted toxin VacA. The VacA toxin exhibits multiple cellular activities, and all H. pylori strains possess a vacA gene. This gene displays allelic diversity in two main regions: the signal (s) region (s1 and s2) and the middle (m) region (m1 and m2). Different combinations are associated with vacuolating capabilities. In addition, vacA s1/m1 strains are correlated with greater vacuolating activity and gastric disease, while vacA s2/m2 strains appear to be nonvacuolating [16–18].
Thus, the absence of an association with H. pylori positivity is understandable, as is the strong association between cagA and s1/m1 of vacA factors, and as well as their association with gastritis and gastric cancer. The secretion of the vacuolating toxin vacA has been found to induce vacuole formation in the gastric epithelial cellular membrane, as well as the modulation of apoptosis rather than the secretion of inflammatory cytokines. These mechanisms, in turn, influence gastric carcinogenesis [19].
The strong association between the inflammatory process and gastric carcinogenesis is very important in the evaluation of genetic polymorphisms in cytokine genes. The polymorphism in the TNF gene promoter region may influence not only cytokine gene expression, but also susceptibility to disease and pathogenesis [20]. Furthermore, the relationship among genes, host cytokine polymorphisms, their expression, and the severity of clinical outcomes in the ethnically diverse Brazilian population needs to be further characterized.
We believe that the relationship between the host genetic factors and the genetic factors of H. pylori can determine the severity of gastric disease in infected individuals. Thus, the aims of the current study were to determine the expression levels of the TNF-α cytokine gene in tissues samples from gastric cancer patients, chronic gastritis patients and uninfected controls, to evaluate the TNF-α -308 G > A polymorphism, and to determine the influence of H. pylori, cagA, vacA and dupA virulence markers on gastric carcinogenesis.
This study was approved by the Research Ethics Committee of Sacred Heart University (Universidade do Sagrado Coração) in Bauru, São Paulo, Brazil (under registration n. 068/12). Written informed consent was obtained from every patient involved in the study. All tissue samples were obtained by means of endoscopy or gastric surgery, procedures which were performed in the Department of Gastroenterology at Marília Medical School, the São Paulo Hospital, or the João de Barros Barreto University Hospital.
Study population
One hundred and thirty-four gastric biopsy samples were collected from patients of both genders (61♂/73♀, mean age 40.3 ± 24.2 years) with gastric symptoms. Histological parameters were analyzed and revealed 70 patients with chronic gastritis (G), 40 with normal gastric tissue (C), and 24 with gastric cancer (GC) tissue. The histological parameters were classified according to the Sydney system [21] and Lauren's classification [22]. Patients exposed to chemotherapy or radiotherapy before surgery or those who had received antimicrobial therapy, anti-cholinergic and anti-inflammatory agents, or proton pump inhibitors up to 30 days before endoscopy were excluded.
DNA extraction and H. Pylori status
DNA from gastric biopsies was extracted using the QIAamp® tissue kit (Qiagen, Germany) according to the manufacturer's recommendations. The presence of H. pylori and virulence markers from cagA, vacA and dupA genes were all detected using polymerase chain reaction, as in previous studies [23–27].
Genotyping of TNF-α
The -308 (G > A) polymorphism of TNF-α was characterized using both polymerase chain reaction (PCR) and the restriction fragment length polymorphism (RFLP) technique according to the Wilson's protocol [28].The 107 base pair fragment was amplified using the primers 5′AGGCAATAGGTTTTGAGGGCCAT3′ and 5′TCCTCCCTGCTCCGATTCCG3′, and the amplification condition that was utilized included 35 cycles: 45 s at 94 °C, 45 s at 61 °C, and 45 s at 72 °C. The amplicons were digested with NcoI (Fermentas, USA) overnight at 37 °C, visualized in 3 % agarose gel, stained with ethidium bromide, and analyzed using an Alpha Imager 2200 (Alpha Innotech Corporation™). The fragments visualized were 107 bp in length in the case of allele A and 87 and 20 bp in length in the case of allele G.
RNA Extraction and cDNA Synthesis
After collection, the biopsy fragments were immediately placed into an RNAlater solution (Applied Biosystems™, USA) and stored at -20 °C until use. Total RNA was isolated using an RNeasy Mini Kit (Qiagen, Germany), and RNA concentration and quality were measured using the NanoDrop 2000 Spectrophotometer (NanoDrop, USA). The concentration was adjusted to 500 ng, and cDNA synthesis was conducted using High-Capacity cDNA Reverse Transcription Kits (Applied Biosystems™, USA) following the manufacturer's instructions.
Quantitative analysis of TNF-α gene expression
In order to determine TNF-α gene expression (Hs01113624_g1), the normal gastric tissue sample, which was negative for H. pylori infection, was designated as a calibrator. All reactions were repeated, and GUSB (Hs00187320_m1), UBC (Hs00221499_m1), and TBP (Hs00187332_m1) were used as reference genes.
The expression level was measured using the TaqMan® System (Life Technologies, USA) within the Applied Biosystems 7500 Fast Real-Time PCR system (Applied Biosystems™, USA). Relative quantification (RQ) was calculated using the comparative CT method (2-ΔΔct).
Statistical analysis
The χ 2 test was used to compare the TNF-α allele and genotype distributions. Odds rates (ORs) were calculated using a dominant model (i.e., combining heterozygotes and homozygotes for the minor allele). To analyze gene expression, the two-tailed Student's t-test was used. Statistical analyses were performed using the GraphPad Prism 5 statistical package. Statistical significance was accepted at p < 0.05.
H. Pylori infection and virulence markers
Presence and characteristics of Helicobacter pylori in gastric biopsies
Histolohy (N/%)
Positive samples (n%)
cagA+ (%)
dupA+ (%)
vacA (%)
Control (40/100)
3 (7.5)
1 (2.5)
1 (2.5)
1 (2.5)
2 (5)
Chronic gastritis (70/100)
47 (67.1)
19* (27.1)
25 (35.7)
19* (27.1)
21 (30)
7 (10)
Gastric cancer (24/100)
21 (87.5)
20* (83.3)
15 (62.5)
21* (87.5)
Total (134)
For the other analyses, the group with gastric cancer tissue that also tested negative for H. pylori was excluded due to the low sample number.
TNF-α-308 (G > a) polymorphism
Genotype and allele frequencies of −308 G > A polymorphism of the TNF-α gene, adjusted for the presence of. H pylori in patients with normal gastric mucosa, gastritis and gastric cancer
Normal (n = 40)
Chronic gastritis (n = 70)
Gastric cancer (n = 24)
Hp + (n: 03)
Hp - (n: 37)
Hp + (n: 47)
Hp - (n: 23)
OR (95 % CI), p
Hp + (n: 21)
Hp - (n: 03)
OR (95 % CI, p
03 (100 %)
30 (81 %)
34 (72.3 %)
18 (78.3 %)
1.55 (0.48-4.98), 0.46
15 (71.4 %)
02 (66.6 %)
3.66 (0.48-27.85), 0.2
04 (10.9 %)
09 (19.1 %)
05 (21.7 %)
03 (14.3 %)
01 (33.4 %)
03 (8.1 %)
04 (8.6 %)
03 (14.3 %)
6 (100 %)
64 (86.5 %)
77 (82 %)
41 (89 %)
1.36 (0.61- 3.03), 0.55
33 (78.5 %)
05 (83.3 %)
1.84 (0.70- 4.81),021
10 (13.5 %)
17 (18 %)
05 (11 %)
09 (21.5 %)
01 (16.7 %)
TNF-α expression in patients with gastritis and gastric cancer
It is important to note that, in the expression analysis, samples from all of the test groups were compared to the normal gastric tissue samples, which were negative for H. pylori infection (control group RQ = 1.072).
Comparing the mRNA expression between control and case groups
Histology analyses
RQ Mean ± SD
Control group (n = 37)
Case groups
Normal gastric tissue Hp-
2.912 ± 2.03
Gastritis Hp+
3.774 ± 1.98
Gastritis Hp-
1.297 ± 0.89
Neoplasic Hp+
1.163 ± 1.09
Conversely, there was no statistical difference observed when the control group (RQ = 1.072) was compared to patients with gastric cancer. Expression in neoplastic tissue (RQ = 1.163; p = 0.6332) did not present any alterations (Table 3).
Correlation among TNF-α gene expression, -308 (G > a) polymorphism, and H. Pylori virulence markers
No association was observed between the genotypes or alleles of the -308 (G > A) polymorphism and TNF-α gene expression in any of thesamples. First, gene expression of the samples withG/G genotypes was compared to that ofG > A + A/A genotypes in patients with gastritis (p = 0.8269) and with gastric cancer (p = ns).The small number of A/A genotypes,particularly in the gastric cancer samples, may have influenced theanalysis. In subsequent analyses, gene expression was compared tothe presence of cagA gene (p = 0.4677), to the presence of thedupA gene (p = 0.0518), and to genotypes s1/m1 and s2/m2 of the vacA gene (p = 0.3578). The presence of more pathogenic of H. pyloristrains did not induce changes in TNF-α expression. In addition, cagA, vacA and dupA genes were not found to be associated with differential gene expression of TNF-α cytokine.
H. pylori infection in gastric mucosa causes an inflammatory response in the host characterized by infiltration of immune cells such as macrophages, neutrophils, and lymphocytes. This reaction is most likely induced by the contact of the bacterium with the epithelium; however, it has been estimated that only 20 % is adhered to the gastric mucosa and therefore able to activate the inflammatory response [29].
Thus, it is evident that virulence factors play a more important role in the progression of gastric carcinogenesis than the mere presence of the bacteria does.
The TNF-α cytokine plays an essential role in host immunity against infectious disease and cancer progression [30]. However, studies on the association between TNF-α-308 G > A polymorphisms and gastric carcinogenesis are very controversial [31–35].
Li et al. [6] evaluated several studies on the TNF-α-308 G > A polymorphism in different ethnic populations. In Caucasian populations, they demonstrated a weak association between the TNF-α-308 A variant and gastric cancer risk. Meanwhile, no associations were found between this A variant and gastric carcinogenesis in East Asian samples or other ethnic populations, including the Brazilian population. Two of the most recent Brazilian articles cited in this meta-analysis evaluated patients with chronic gastritis and gastric cancer and did not find any association between the TNF-α-308 A polymorphism and gastric carcinogenesis [4, 36].
The association between inflammation and disease progression is well described in a gastric cancer model, which begins with chronic gastritis that persists and may induce changes such as metaplasia, dysplasia and, finally, cancer [37]. We also observed that, in patients with chronic gastritis, TNF-α mRNA was overexpressed in relation to the control patients, and the association was greater among patients who had gastritis and were also H. pylori positive. On the other hand, there was no increased expression in patients with gastric cancer. These results indicate the involvement of this cytokine in initial carcinogenesis. A recent study with a mouse model showed that TNF-α is also produced in excess in early colonic lesions in cases of colorectal cancer, and the data supported the closest association between TNF-α and early tumor progression [38].
Bartchewsky et al. [39] showed that patients with chronic gastritis infected by cagA-positive strains of H. pylori had the highest cytokine mRNA and protein levels. However, we did not find an association between higher cytokine mRNA level and patients infected by cagA-positive strains. Santos et al. [4] found similar results regarding the presence of the TNF-α-308 G > A polymorphism and infection by cagA-positive strains. This polymorphism apparently does not affect the presence of H. pylori or the progression of gastric disease.
More recently, Caliskan et al. [40] performed a study to determine the relationship between among H. pylori genotypes and their effects on cytokine release levels. These authors studied five genotypes: cagA and vacA s1m2 (genotype 1); cagA and vacA s1m1 (genotype 2); cagA, vacA s1m2, and babA2 (genotype 3); vacA s2m2 (genotype 4); and cagA and vacA s2m2 (genotype 5). These researchers found that all of these genotypes increased IL-1β, IL-6, IL-8, IL 10, and TNF-α levels in THP-1 cells. However, genotype 5 was found to cause higher amounts of IL-1β, IL-6, TNF-α, and IL-10, whereas genotype 1 induced the highest levels of IL-8. Thus, they suggested that the host cytokine response varies depending on the individual specific immune response to different H. pylori strains.
In another recent study, Michalkiewicz et al. [41] analyzed gene expression of innate immunity and cytokines in the gastric mucosa from H. pylori-infected children and uninfected children and found high mRNA expression of IL-6, IL-10, IFN-γ, and TNF-α. However, H. pylori cagA-positive strains were associated only with higher IL-6 and IL-10 mRNA expression in relation to the cagA-negative strains. Meanwhile, TNF-α presented increased protein levels and was correlated with bacterial density.
Our results are consistent with those of several authors, and we offer two hypotheses. It is possible that bacterial density, not the H. pylori genotypes, stimulates mRNA synthesis of TNF-α. It is also possible that an increase in protein levels occurs without a significant increase in gene expression. The important finding is that, regardless of the pathway, TNF-α induces an intense inflammatory response that inhibits gastric acid production and suggests a worse prognosis.
In addition, we found that, contrary to results reported in the literature, TNF-α-308 G > A polymorphisms did not influence TNF-α mRNA expression in cases of gastric disease. In patients with postoperative sepsis, Baghel et al. [20] revealed that the AA homozygous genotype presents a greater capacity for producing TNF-α cytokines than other genotypes. Higuchi et al. [42] reported that the A variant of the TNF-α-308 polymorphism presented higher transcriptional activity and increased TNF-α cytokine production. Hosono et al. [43] found increased tumor necrosis factor receptor 1 expression in human colorectal adenomas, though TNF-α expression did not differ significantly.
These contradictory results may be explained, at least in part, by the fact that the Brazilian population is composed of a genetic miscegenation of various ethnic groups. This variation may influence allele and/or genotype frequencies and their correlations with gene expression. Furthermore, most studies evaluate protein levels of TNF-α, which are not necessarily associated with the mRNA levels of TNF-α. A recent study published by de Oliveira et al. [44] found results similar to ours. These authors reported that the polymorphic alleles of TNF-α (-308) did not have any effect on TNF-α or IL-10 expression levels. It is important to note that this study was performed on a Brazilian population and reinforces the hypothesis mentioned above.
Ours results show that the presence of Helicobacter pylori induces a large increase in TNF-α expression in patients with gastritis, regardless of tissue inflammation, but after the tissue becomes neoplastic, the presence of bacteria did not influence expression. These results suggest that the TNF-α pathway may play an important role in the progression from gastritis to gastric cancer.
Ethics committee approval
This study was approved by the Research Ethics Committee of Sacred Heart University (Universidade do Sagrado Coração) in Bauru, SP, Brazil (under registration n. 068/12).
Written informed consent was obtained from all patients or their legal guardians for publication of this case report.
The authors would like to thank the State of São Paulo Research Foundation (FAPESP) for the funding of this research (grant numbers 2012/18333-3, 2013/21224-4 and 2013/21285-3).
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Authors' Affiliations
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EAST HARTFORD — An East Hartford high school, the Connecticut International Baccalaureate Academy, has been awarded the top spot in a national ranking for best high schools in Connecticut.
The academy, located at 857 Forbes St., was recognized as the best high school by U.S. News & World Report, a company that publishes news, consumer advice, rankings and analyses.
Other schools among the top 10 include West Hartford's Conard High School, Simsbury High School and Farmington High School.
Conard was fourth in the state rankings. West Hartford's other public high school, William H. Hall High School, was 12th. Both consistently rank as among the best in Connecticut.
To formulate its rankings, U.S. News examined schools' enrollment and demographic data and test scores. It also evaluated how schools compared with others, both locally and nationally.
"It really is a tribute to my students and their work, my teachers and their work and the parents of our students who see a vision of their students through education," said academy Principal Caryn Stedman. "This recognition really shows that with a rigorous curriculum, a group of caring, committed teachers and supportive parents, students can achieve at very high level."
The magnet school, one of East Hartford's two public high schools, also ranked 34th in the nation. It follows the International Baccalaureate Middle Years Programme model for grades 9 and 10, and the Diploma Programme model for grades 11 and 12.
West Hartford School Superintendent Thomas Moore the recognition of the town's two high schools "is a reflection of the support that the town gives to our schools and that West Hartford believes in education."
"It's a good day for West Hartford, no doubt about it, and I'm very proud of our kids," Moore continued. "To both be in the top 15 high schools in the state of Connecticut, we consider both high schools to be equally great high schools for our kids."
Simsbury High School was sixth in the state list. Superintendent Matthew Curtis said the recognition was gratifying.
"However, we try not to lose sight of our long-term goal of consistent performance over time," Curtis said. "Simsbury has a long-standing record of excellence because of our incredible programs, staff and students and because our parents and community provide so much support for what we do."
Courant Staff Writers Suzanne Carlson and Kristin Stoller contributed to this report.


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Dear fellow Washington Print Club members,
The Washington Print Club continues strong and productive. Educational programs are well attended and new ideas have been inaugurated or are under discussion [see below].
The focus of the fall series of educational programs remains as varied and diverse as the membership itself. Two of the programs revolved around special exhibitions at the National Gallery of Art: "Drawings for Paintings in the Age of Rembrandt." and "Photography Reinvented: The Collection of Robert E. Meyerhoff and Rheda Becker." Both programs were led by the organizing curators. The former show probably was one of the most thought-provoking exhibitions in a long while.
Because of the realistic nature of Dutch seventeenth-century art, the general assumption is that they were produced while looking at the subject depicted. This, of course, turns out to be incorrect. Indeed, in the words of Karel van Mander, a sixteenth-century Flemish artist and theoretician: "drawing is the portal to many of the arts." Among the different drawing types discussed were: compositional drawings; individual figure studies; counter proofs; carefully ruled construction drawings; presentation sheets; and sketchbooks.
The tour of "Photography Reinvented" was an equally fascinating experience. The eighteen photographers represented are at the forefront of redefining the role and direction of contemporary photography. At the heart of the reinvention are issues about the ways photography does and does not render reality and the interplay between its flat shapes and its instantaneous representation of the three-dimensional world before the lens.
Other educational programs included a visit to the home of one of our member collectors. It was an amazing treat and awe-inspiring revelation. Art was everywhere-even on the ceiling! At the center of this vast and phenomenal collection is the work of the sub-continent Indian artist Bhupen Khakhar (1934-2003). Earlier this year the Tate Modern in London mounted a landmark exhibition entitled "Bhupen Khakhar: You Can't Please All." A substantial member of the member's paintings and works on paper were included.
In an effort to expand our programs and to enlarge our membership, the Print Club partnered for the first time with The Washington Printmakers Gallery and Georgetown University's Lauinger Library. An exhibition of the prints of Werner Drewes was presented during November at the Printmakers Gallery while, Georgetown University hosted an exhibition entitled "Color in Relief: Wood Block Prints from Origins to Abstraction" which included the work of Drewes. At the center of the two events was a symposium about woodcuts, their evolution, and relevance for the twenty-first century. In addition, as part of the celebration, a folio of prints was commissioned combining one work by Werner Drewes with modern images commissioned from members of American Abstract Artists based in New York.
The Club's bi-annual publication On Paper has published its second edition. Both editions have met with universal praise for their layout and their articles. This recent issue has a cover color image of a print by Martin Puryear [Three Holes, 2002] along with a lengthy illustrated article on his prints and sculptures. Other articles discuss James Gillray and British caricature; reduction prints; the work of Donna Diamond; a members trip to Cuba; and, a linocut by Artemis Rodriguez.
The second of the Washington Print Club's new initiatives will be inaugurated in 2017. It is awarding of a cash prize to the best print student at a specific recognized arts program throughout the region. The first prize will be given to a student from the Maryland College of Fine Art in Baltimore. The school's art faculty will chose the recipient and the Washington Print Club will provide the $1,000.00 prize. It will be awarded at next year's annual membership meeting and reception. The features that make this idea so intriguing are that the Print Club will work with one arts institution per year and the specific institution will rotate annually among the myriad fine arts faculties in the greater Baltimore-Washington area.
Christopher With,
The Washington Print Club


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Get in the Ring believes that startups need fans if they're going to be successful. During the competition fans from all over the world follow their favorite startups in their journey to the International Final through the local, national or regional finals or online through the live webcasts of these finals.
In only three years'time Get in the Ring grew from a local event to a global competition in 64 countries. The competition is a featured event of the Global Entrepreneurship Week.
Through National and Regional Finals startups will be selected for the International Final.
Get in the Ring aims to challenge the status quo of pitching. The minds of the investors need to be triggered. For this reason, Get in the Ring changed the way people are pitching and has introduced a new unique pitching concept. Startups getting in the ring will battle it out, one on one, during five different rounds. Each round focuses on a relevant topic that all investors are interested in.
During the Investment Battle two startups will be pitching at the same time, called a battle. Every battle consists of five rounds and every round will focus on a different subject important for a business. Per round, entrepreneurs will have approximately 25 seconds to convince the champions, the jury, on each subject. After five rounds every participant will be asked questions by the jury (called the Champions). This will take 5 minutes per participant.
The rounds include:
- Team
- Achievements
- Business model & market
- Financials & investment proposition
- Freestyle
After the question round the Champions will choose which startup is the winner of the battle. The winners of each battle will go through for the voting round.
Eligibility Criteria
In order to participate, startups need to meet the following criteria:
– Exists no longer than 8 years
– Be proficient in the English language
– Have a scalable and innovative business idea or model
Startup Phase
– Showing clear, growing and measurable user and market traction in a big or rapidly growing target market.
– Can and wants to scale fast.
– Can be able to attract significant funding
Judging Criteria
– Team qualifications and experience
– Achievements
– Scalable and innovative business idea and/or model
– Market opportunities
– Fundability of the startup


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For many, today this means Valentine's day, but in the Gallagher household, this means the lead up to Gallifrey One, the premier annual Doctor Who convention that takes place in the LAX Marriott Hotel. This will be my 6th year attending (not including my facetimed from France experience!), and if you have gone or attempted to get tickets for this, you know how lucky that is.
This year, I'm coming at the prep and thought process for this event differently than I have before. The hotel is fairy close to home so while I could go out and retrieve anything I accidentally leave behind quite easily, this is always a pain; in this light, I'm not talking about checking and double checking on all your gear, including fittings.
Since experiencing the magnitude that was Boston Comic Com. and the shifts in schedules, shifts in lines, crowd control, and so many things happening all at once that you just miss out, I've begun to appreciate planning ahead so much more (as if I didn't already, right?).
So, this week (besides binge watching a bit of DW Series 1) I will be going over the online schedule and picking all my time slots – and time to grab a bite or two to eat! – and plotting out my budget. This online schedule has a customizable option I will definitely be checking out asap!
If you do have tickets, be aware that there is a new 'no videotaping panels' rule – pictures are great but, because people have been posting whole panels rather than clips, there is no unofficial filming. Still, if this ruins your weekend, remember you are lucky to be there!
So, wear your Union Jack with pride, take my hand, and (as always): Run!
This is Leave on the Wind, helping you soar.


text: On Fri, 11 Dec 2009 13:26:41 +0100 Jan Henrik Sylvester wrote: > Boris Samorodov wrote: > > here is a patch to switch to Emacs 23 as a default. There are > > 50 affected ports. Tests were done at tinderbox. Please give > > this patch a try. I'm going to fire up an exp run after some > > testing. The patch is relative to PORTSDIR: > You already know that I have been running emacs23 (with auctex, cedet, > elib, and jde) for a while with patches that are practically the same, > but in case you are waiting for more success reports with your current > patch, I rebuild my *emacs*-ports on two different 8.0-RELEASE > machines (i386 and amd64), created packages, moved them on to another > machine, and tried emacs (with auctex) there. Everything seems to be > fine. Gary, Jan, thanks for testing. I've submitted a PR: http://www.freebsd.org/cgi/query-pr.cgi?pr=141369 -- WBR, Boris Samorodov (bsam) Research Engineer, http://www.ipt.ru Telephone & Internet SP FreeBSD Committer, http://www.FreeBSD.org The Power To Serve


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Local News Stage Manager Fills in for Missing Traffic Reporter, Is Terrible [VIDEO]
During a live broadcast, the traffic reporter for Fox's affiliate in Western Michigan failed show up for his segment, leaving viewers to stare at a traffic map and nothing else.
After about seven seconds of this awkward silence, stage manager Mike Davis — who happens to bare a striking resemblance to Larry David — entered into the shot and gave a hilarious, impromptu traffic report using only arm gestures.
No word on whether the traffic reporter was late because he was stuck in traffic, but he better start showing up on time or Davis is going to have his job.
[via Huffington Post]


text: Posted by Joyce Steward on November 15, 2009 ROTARY, FREEMASONRY AND THE ROMAN CATHOLIC CHURCH Blog ROTARY, FREEMASONRY AND THE ROMAN CATHOLIC CHURCH This badge was found by our historian colleague, Dr. Wolfgang Ziegler and triggered off a search for its origin which has not yet been resolved. The central part of what is otherwise a normal Rotary lapel badge, seems to show the symbols of Freemasonry, the set square and compasses, while the letter 'G' in the centre is also an indication of the Scottish Rite of Masonry. We know that many of the early Rotarians were Masons and that, according to C.R. Hewitt in 'Towards My Neighbour', some Rotary clubs recruited exclusively from Freemasons until the practice was banned in the 1920s. To date, no precise details of these links have been found in the archives of either body. Many such details are not clear when we look back at things that have come into existence many years ago. A lot of research is required to unearth the meaning behind many things. The fear of the unknown is one that spares none and many hesitate and fear the worst when they are not sure about what they are associated with. A trader goes through this feeling very regularly as he does not know what will happen to the market and this anxiety may cause him to take wrong decisions. Automated software like The Brit Method, prevents such mistakes. The relationship was a matter of some discussion and in February 1923, an article in 'The Rotary Wheel' sought to allay fears among Rotarians who might think that their membership of the one could cause problems in the other. However, many people who did not know much about these organisations, thought that Rotary was a form of Masonry. This eventually led to a much more serious problem when the Catholic Church, which had long been an antagonist of Masonry, classed Rotary as a similar organisation. Also see the Ziegler Collection G.K. Chesterton who was often a vocal critic of Rotary, was a Catholic convert. and his adherence to the sectarian line may have coloured his views. The problems seem to have started in Spain about 1928 when the Bishops of Almeria, Leon, Orense, Palencia and Tuy laid charges that Rotary is "nothing else but a new satanic organisation with the same background and teachings of masonry" and that "according to documents and reliable sources, Rotary is a suspected organisation, and should be considered as execrable and perverse". The Church also criticised and condemned Rotary for showing a concept of life and of service without reference to church teaching. Indeed, it seems that they believed it a secret society with quasi-religious overtones as many in the Church thought was the case with Freemasonry. For whatever reason, the Vatican took up the reins and in 1929 issued a decree that "it is not expedient" for Catholic priests to participate in Rotary either as members or guests. This decree and its implications were worrying to the many Catholics in Rotary not the least the then President Tom Sutton who was himself a Catholic, and former Chancellor Germany Wilhelm Cuno, a member in Hamburg. Critical and at times disparaging articles regularly appeared in Catholic newspapers, especially in the 'Civilta Cattolica' in Italy, and Tom Sutton went off to Rome to try to convince the Papal authorities that Rotary was not Masonic, and that it was a movement which was not in conflict with any Catholic teaching. Sutton's attempts to convince the Secretary of State in the Vatican, Cardinal Gaspari, were fruitless and the anti-Rotary articles continued to be published. An even more virulent article later appeared in Paris in 'La France Catholique' making allegations about both Paul Harris and the links between Rotary and Freemasonry, which were later reprinted in the Baltic paper 'Rytas'. The factual errors could be, and promptly were shown to be false, and by 1933 there was a mood swing in the Vatican, perhaps partly occasioned by the number of prominent and influential Catholics throughout the world who were joining Rotary. Priests were now allowed to use their discretion about attending or even joining Rotary. Nevertheless, one of the results of the Church's attitude was the slow development of Rotary in some predominantly Catholic countries such as Ireland. This uneasy peace continued until 1951 when another Vatican decree warned priests that they should not join Rotary and that "the faithful should be aware of seditious and suspected organisations". By then, however, the world had changed and the decree caused an immediate angry response, among others from the then Catholic President of RI, Arthur Laqueux, and from the Rotarian Catholic Bishop of Fort Wayne, Indiana, who publicly declared the decree "quite incomprehensible". Fairly soon, the Vatican began to retract. The official newspaper 'Osservatore Romano' wrote "In some nations, because of a prevalent Masonic influx, the action of Rotary Clubs has conflicted with the activity and the needs of the Church. It must be said, however, that such has not been the case in other nations where the attitude of Rotary has shown itself in practice tolerant and benevolent towards religious interests."By the end of the decade, the Catholic Truth Society was able to declare that "Rotary is neither secret nor seditious". It was nevertheless still regarded as a "society banned under pain of sin only" and not of "sin and excommunication". Gradually there was a thaw in relations between the Church and Rotary. In 1970 Pope Pius VI addressed Rotarians in Italy, and in 1979 Pope John Paul II spoke to the International Convention in Rome, praising some of Rotary's humanitarian programmes at a special audience in the Vatican. Later he accepted a Paul Harris Fellowship and a World Understanding and Peace Award from Rotary, while Catholic priests throughout the world were taking positions of authority, even serving as District Governors. As Alvarez points out, it was not only Rotary that was condemned during the 1930s and 1940s. The Lions Clubs and even the YMCA incurred the wrath of the Vatican. In fact, the condemnation of the Y.M.C.A. was even earlier in 1920 when it was described as "White Masonry", on the grounds that "such organisation, while showing special concern for the youth, corrupted their faith, teaching them a conception of life dispensing with the Church and all religious teachings. The Y.M.C.A. is contributing to the decay of the youth's faith, by affirming that its purpose is to show them a conception of life without churches or religious confession". Joyce Stewardhttp://rotaryfirst100.org/author/info/


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A belated appreciation for Diana Prince
There's a tweet I came across a few weeks ago, back when Wonder Woman just started gaining traction. It is super funny, yet also very true and powerful at the same time:
NO WONDER WHITE MEN ARE SO OBSCENELY CONFIDENT ALL THE TIME I SAW ONE WOMAN HERO MOVIE AND I'M READY TO FIGHT A THOUSAND DUDES BAREHANDED— meg s.s. (@megsauce) June 4, 2017
And it is so accurate. Ever since I saw this film on IMAX, I felt like a warrior was ready to rip herself out of my chest. I was so pumped, so amazed, so awed. It was the story of one woman - a strong, ideal, almost-perfect goddess - and yet, in so many ways, it was also incredibly human.
Unfortunately, this isn't going to be a proper review of the movie. (Although it's definitely a 12/10 for me.) But I'd like to take the time to write about something that is so incredibly rare for me these days: to find something so inspiring. Seeing Wonder Woman embrace this whole idea of being brave amidst it all for the common good - it's uplifting. And truth is, I really needed that.
And these days, don't we all?
(Yeah, sometimes, I spend my short breaks reading superhero comics. When the weight of it all becomes too heavy to bear, I like jumping into a world where the lines between good and bad are clearly drawn. Where we know who the good guys and the bad guys are. I guess it's my way of coping with all this grief and sadness and anger; some sort of coping mechanism.)


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Have you ever hug and kiss your kitchen appliances? My kids laugh at me when they see me hugging and kissing my breadmaker. It has done such a wonderful things in making bread, pizza dough, pasta and even jam for me. It never let me down unless the recipe is a bad one. Over the weekend, I made my first focaccia bread and pasta and that was a delicious "homemade" dinner. Kids asked me what would I do if the breadmaker broke, I would certainly cry but luckily I have a spare. When my husband bought me the Kenwood Chef, it gave me a new breadmaker as a bonus gift. How nice is that!
Focaccia Bread (Breadmaker method)
4 cups baker's flour (I use Defiance)
1 1/2 teaspoon salt
8g instand dry yeast
2 teaspoons olive oil
1 1/4 lukewarm water
1 teaspoon mixed dried oregano and basil
1/2 teaspoon minced garlic
- olive oil, salt, cheese, garlic, dried oregano and basil
- olive oil, salt, garlic, cherry tomato, fresh rosemary
- Pour the liquid ingredients into the breadmaker: i.e. water and oil.
- Then followed by the dry ingredients with the yeast last, i.e. salt, garlic, herb, flour and yeast.
- Press the select button to "dough"
- When the dough is done, take it onto the floured bench or place a piece of baking paper onto the bench. Sprinkle the dough with some flour and roll it into rectangular shape that fitted into the baking tray or small round shape of your choice. (I make one large rectangular and a small square)
- Dimple the surface of the dough with your fingertips. Leave the dough in a warm place for 15 minutes. ( I leave it in a pre-warmed oven)
- Lightly brush the dough with olive oil, sprinkle with salt, herbs, garlic, cheese, halved tomatoes of your choice.
- Bake at 210c for 15-20 minutes or until the bread is cooked through. My dough is a bit thick, I actually bake it about 30 minutes.
- You can cut the bread in half, butter it. Put it under the grill for grilled toast or bruschetta bread.


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Myanmar youngsters gear up for the Football for Friendship Programme in Russia
Source : The Global New Light of Myanmar
View Count : 1013
Jun 02, 2018
MIN Khant Thu and Thant Tay Zar, the selected 12 year old ambassadors from Myanmar will be on their way to Russia on June 8th to participate in the 6th Gazprom Football for Friendship International Programme. They will be joined by kids from over 210 countries around the world, in Moscow.
Min Khant Thu selected in the role of a defender will be a part of the 32 International Teams of Friendship that play against each other in the Gazprom Football for Friendship International Championship. The young footballer will be a part of the "Gharial" team and will undergo a 3 day training camp in Moscow.
The training camp is scheduled for the young ambassadors to get used to the playing conditions and get ample practice with their team, before the start of the championship. Each International Team of Friendship will be trained by 14-16 year old young coaches from different countries. The young footballers will also participate in workshops and sessions, conducted by renowned celebrities.
Min Khant Thu, who hails from Monywa, started playing football at the age of 6. He was scouted by the Myanmar Football Academy who were impressed by his control over the ball. He currently studies and plays for the academy, and dreams to play for a professional football club in the future, like his idol, Lionel Messi. A Barcelona FC fan, this talented, young footballer believes it is important to promote friendship, equality and peace because he believes that we need each of these three things to brighten our world.
Apart from football, this young ambassador also likes to read and sing.
At the F4F Programme in Russia, Min Khant Tu will be accompanied by Thant Tay Zar, who will act as a young journalist and cover all the local and global activities of the program as part of the International Children's Press Center.
The Press Centre acts as hub for the young journalists who gather information, make reports, write news articles and prepare materials on the initiatives implemented as part of the Programme.
Thant Tay Zar is a football enthusiast who hails from Yangon.
He started playing at the age of 6 and made it to his school football team at a young age. He has participated in inter school football tournaments, playing as a striker for his school team. He was selected as a striker for his team because of his speed and his strong control over the ball.
An avid supporter of FC Barcelona, his favourite player is Neymar Jr. In his free time, he likes to read and play video games.
Min Khant Thu and Thant Tay Zar will also participate in the Sixth Football for Friendship International Children's Forum in Russia, which will provide the youngsters an opportunity to meet their peers from other countries, share their experiences, and discuss with famous footballers and journalists on how to promote key values of the F4F Programme around the world.
The International Children's F4F Forum will be participated by famous sportsmen, journalists, and public figures who support the project and provide their thoughts and inspiration to the young athletes.
The young ambassadors will also participate in the Nine Values School programme, where they will be taught about the 9 key values of the F4F programme (friendship, equality, fairness, health, peace, devotion, victory, traditions and honour) under the guidance of young coaches and the supervision of famous players.
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Pitch in any amount now to help re-elect Sherrod Brown, sweep the statewide races and turn Ohio blue -- and we'll send you this Stand with Sherrod car magnet.
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After a three-year break, the King family is back at the helm of Cal's Restaurant and Pizza Express in Garrettsville.
Aaron King and his mother, Carole, took over the ownership of the facility on Nov. 29, and they are eager to return Cal's into one of the top restaurants in the area, they said. Both said they have missed their regular customers and look forward to seeing them again, along with meeting new ones.
The restaurant has and will remain open during the transition period. The Kings do not expect any changes in the staff at this time, as all the employees are being retained.
Although Carole and Aaron King are back at the helm, they will turn the day-to-day management reins of the facility over to Brian Rader, who has been with the family for 25 years. Both Carole and Aaron King will be around to assist Rader. Aaron King is next door at Skylanes Bowling Alley and CaroleKing will be in the restaurant three days a week to assist with the operations.
One of the changes already being implemented by the Kings is going back to their original pizza ingredients.
The pair also recently had the pizza oven, "Big Bertha," rebuilt and it is now ready for use. The Kings said "Big Bertha" is Northeastern Ohio's largest pizza oven.
Expect to see items like veal and eggplant parmesan, and homemade chili return to the menu. The King's will also add slow-roasted prime rib on the menu for Friday and Saturday nights and will go back to their original recipe for fried chicken.
Besides bringing back menu items, homemade specials will return on Wednesdays and Thursdays. Cakes by Carolyn Miller also will return to the dessert menu along with Mrs. Clarke's pies. A new updated menu is being developed and will be implemented soon.
They also have updated their catering menu and redecorated Cal's II, which is available for events and parties.
The restaurant also will be remodeled. The landlord is working with the family to update the facility. Plans include changes to windows and carpeting in the regular dining room.
A new website and social media sites are being developed and will be up and running soon.
Cal's also will offer complete menu delivery service, which means everything on their menu is available for delivery service.
January will mark the 30th anniversary for the restaurant and the 27th for the King family. They are busy planning for specials for their anniversary.
Cal's is located at 8301 Windham St. (S.R 82) in the Sky Plaza and can be reached at 330-527-2133.


text:
Summary: - RESOLVED: Accept Anton's edit merging the sentences in comment 2 and 3 in CSS2.1 bug 16049 about margin-collapsing. https://www.w3.org/Bugs/Public/show_bug.cgi?id=16049 - RESOLVED: Accept Anton's edit about margin-collapsing of a min-height parent and last-child for CSS2.1 bug 16037. https://www.w3.org/Bugs/Public/show_bug.cgi?id=16037 - Closed ISSUE-229 about justification and pre-wrap; text-align already defines this. - RESOLVED: Change the animation model to snapshot much less properties. Details of exactly what snapshotting is left TBD. - RESOLVED: Treat both mismatched string lengths and non-rectangular regions as illegal syntax in Grid/Template. - Discussed -webkit-mask and reflections; and relation to SVG properties and element(). Edward O'Connor to write up what WebKit implements for masking, FXTF to help harmonize with SVG http://robert.ocallahan.org/2008/06/applying-svg-effects-to-html-content_04.html http://people.mozilla.com/~roc/SVG-CSS-Effects-Draft.html ====== Full minutes below ====== Present: Glenn Adams Tab Atkins David Baron Bert Bos Tantek Çelik (via IRC) Arron Eicholz Elika Etemad Simon Fraser Sylvain Galineau Daniel Glazman Vincent Hardy Molly Holzschlag Koji Ishii John Jansen Brad Kemper Chris Lilley Peter Linss Edward O'Connor Anton Prowse Alan Stearns David Storey Steve Zilles <RRSAgent> logging to http://www.w3.org/2012/04/11-css-irc <glazou> FWIW, we have the transition conf call for both Backgrounds and Images later today ScribeNick: TabAtkins Administrative -------------- plinss: Last minute items? glazou: Maybe the email about webkit-mask and reflections. glazou: I just read that Ted will submit a proposal to the WG. glazou: But maybe we need to discuss what to do about that. fantasai: I think we did discuss that at some point. vhardy: I'd like this to be in the FXTF charter, as this is related to SVG as well. <fantasai> IIRC, we concluded that reflections should be done with filters or some other generic mechanism plinss: Where will it live and how much priority? glazou: we don't need to discuss it right now. plinss: Start with margin-collapsing, then. Margin Collapsing ----------------- plinss: Any remaining issues? antonp: One and a half, yes. antonp: The one we got halfway through last week... antonp: Is the bug I'm about to paste. <antonp> https://www.w3.org/Bugs/Public/show_bug.cgi?id=16049 antonp: This concerned a note in chapter 10 about min-height and max-height. antonp: It was a confusing note; arron and I came up with a simpler note. antonp: We just removed most of the note completely. antonp: But fantasai wanted to keep some mention of margin-collapsing in that note. antonp: So she proposed some wording. <fantasai> http://lists.w3.org/Archives/Public/www-style/2012Apr/0101.html antonp: Rather than take her exact wording, I thought we could resolve to something similar. <antonp> last week fantasai proposed: "for example, margin collapsing is not affected because it's based on computed values and not used values" antonp: The proposal can be found in that bug report. antonp: Scroll down to the very end of the comments to see the proposal from last week. antonp: I'm fine with adding an extra line along the lines of what fantasai proposed, but I'm not entirely happy about her exact wording. antonp: I agree that a note about margin-collapsing here could be useful antonp: But if it's needed, it's because the calculation for min/max height need a temporary value of what the computed height is. antonp: And the idea of the note is that you're *not* supposed to re-think about margin-collapsing when doing the real height. <fantasai> suggest s/affected/recalculated/ in the note antonp: So I'd prefer what I said in note 3. antonp: So the full proposal is to take the sentence in comment 2 and the sentence in comment 3 and put them together. antonp: last week we agreed on the comment 2 sentence, but there was some confusion about the comment 3 sentence. * fantasai defers to dbaron :) <dbaron> fine with me plinss: I hear no objections. RESOLVED: Accept Anton's edit merging the sentences in comment 2 and 3 in the bug report about margin-collapsing. <antonp> https://www.w3.org/Bugs/Public/show_bug.cgi?id=16037 antonp: In this case, we've got an auto-height parent with a large min-height. antonp: And it contains a last-child. antonp: Should there be collapsing between the margin of the last-child and the margin of the parent? antonp: We discussed this in Paris and drew some diagrams. antonp: And we more-or-less agreed that we should do collapsing, even though it seems a bit strange in this case. antonp: It turns out this bug has a relationship to bug 16036 which we discussed last week. antonp: In the comments there's some mention of this, and how it influences the wording we need to use to fix 16037. antonp: The proposal is in comment 5 of the bug report. antonp: This makes things a bit clearer. antonp: It splits the conditions into a list, rather than a long complicated sentence. antonp: In the previous spec it was a complex sentence, but the addition we're making renders it much harder to read. antonp: So hopefully we're achieve the desired effect, which is to say that margin-collapsing does occur between the last child and the bottom margin of the parent in this case. antonp: This is currently part of a giant note. antonp: It was previous normative, but it was recently changed to a note so it could be changed to more readable and comprehensive normative text later. dbaron: So the change is that you're removing the mention of min-height at the beginning of the sentence, and adding a mention of it in the third bullet? antonp: Yes. antonp: I don't think the current spec is quite wrong, I think it's just overly specific. antonp: And because of that, it gives you the impression that you wouldn't collapse in another condition. antonp: And we're saying there can be collapsing in another condition as well. antonp: Giving very specific conditions can be misleading if there's a more general rule in actuality. dbaron: Sounds okay to me, though I haven't worked through it in full detail. plinss: Can this change behavior in some cases? Do we have testcases? antonp: I'm not aware of any specific testcases for this. <Katie> [Microsoft.aa] has Katie antonp: There are testcases around this, but as soon as you get into complex sets of conditions for margin-collapsing, there usually aren't testcases. antonp: I'm all in favor of adding testcases. plinss: I'd like to see testcases for this. antonp: Does that mean you'd like to see a testcase before resolving? plinss: I think so, unless someone really wants to resolve now? mollydotcom: I think that personally if the language is clear, it's fine. mollydotcom: It seems that in what Anton described, that's the behavior that people expect. TabAtkins: I disagree - margin-collapsing is ridiculously complicated, so we need testcases anyway. <smfr> TabAtkins++ mollydotcom: I just mean that if the language is clear, it's not required that a testcase appears before we accept the note. RESOLVED: Accept Anton's edit about margin-collapsing of a min-height parent and last-child. antonp: The other issue in the agenda doesn't seem to have priority. I can postpone. plinss: Sounds good. Justification and White Space ----------------------------- Scribe: dbaron plinss: Next topic - combining justification and white-space: pre. fantasai: I think this is already resolved because of a decision we made about 2.1 -- should already be in the spec. TabAtkins: Was it put in the spec more than a month ago? fantasai: Says in the section on 'text-align': ... reads from spec... fantasai: Well, there's obviously a missing "not" in the sentence, but otherwise it's there. TabAtkins: This does work once that is changed from collapsible to non-collapsible, which means this is fine. http://www.w3.org/TR/css3-text/#text-align "If an element's white space ... must ensure that tab stops continue to line up as required by the white space processing rules." breaking replaced elements -------------------------- ScribeNick: TabAtkins fantasai: I haven't triaged any css3-break issues yet, and rossen's not on the call, so we should defer this issue until the two of us have had a chance to look at it. plinss: Vincent, are you okay with deferring? vhardy_: Yep. animation-fill-mode ------------------- <plinss> http://lists.w3.org/Archives/Public/www-style/2012Mar/0445.html plinss: Next, interaction of animation-fill-mode with running/completed animations. sylvaing: What happens if the animation-fill-mode is updated after an animation is started or after it's completed? sylvaing: There's some language about snapshotting the values when an animation starts. dbaron: I don't like the whole wording about capturing values. sylvaing: So what do we do then? dbaron: I think this should have an effect either way. dbaron: You have an animation, it starts at some time, and you can compute ... dbaron: The things that have an effect at the time the animation starts are duration, delay, and name. sylvaing: So those you'd treat as if they're snapshotted. sylvaing: So if you have a 2s delay, and after 1.5s you update it to a 3s delay, what do you do? dbaron: I think I wrote something about this a year ago, trying to remember. sylvaing: The snapshotting is simpler from implementation. sylvaing: But if we don't do it, we still need something clear and predictable. dbaron: My memory of what webkit does is that they snapshot some things, but not as much as the spec says. dbaron: My general issue is that anytime you snapshot, you're exposing more details about when changes occur. dbaron: So if you set an animation and then change a property about animations, whether it affects the animation or not depends on how you batch style changes. sylvaing: So what do we do instead? dbaron: I think what I proposed was that you compute a start time for the animation based on when animation-name changes. dbaron: If someone sets play-state to 'paused', while it's paused it moves that time forward. dbaron: But otherwise the only thing you snapshot is that start time. smfr: So you're suggesting that authors can change iteration-count or direction while it's running? dbaron: Yes. smfr: If you're halfway through a reverse iteration and you suddenly change animation-direction, it'll jump. sylvaing: So how does this stop detecting style batching? You're still in control of when you apply animation-name. smfr: Were you suggesting that duration is snapshotted as well? dbaron: I don't think so. TabAtkins: I think the implication there is that if you're 2s into an animation, and you change duration to 1s, it would automatically end and fire an animationend event. dbaron: Maybe something like that. sylvaing: I think the snapshotting has its downsides, but it's simple and predictable. dbaron: That's not what webkit did - it didn't match the snapshotting. sylvaing: Sure, but we could consider that to be a bug. sylvaing: Is this better for authors? smfr: We've had feedback that people want to change animation-duration after the animation has started. vhardy: I also think it's better to have a live model than a snapshot - this is the SMIL model too. [discussion about needing testcases] TabAtkins: Testing seems to be a red herring - we'll need it anyway. We need to decide between snapshot everything, snapshot some, or snapshot minimum. sylvaing: Current impls don't quite snapshot everything. smfr: Delay is interesting if you push it forward past the current time. dbaron: I think Gecko snapshots delay. dbaron: We compute a start time, and that involves delay. plinss: To me, it makes sense to let delay change if the animation hasn't started yet, and disallow it if it hasn't. dbaron: And if you set the delay back before the current amount of time delayed, start then or start as if it was delayed there the entire time? TabAtkins: I think the latter. plinss: So question is snapshot some, or snapshot minimum? sylvaing: Seems that snapshotting less seems reasonable. vhardy_: SMIL's lack of snapshotting is convenient and solves some problems. plinss: Seems reasonable. sylvaing: I think we're agreed not to keep the snapshotting. Maybe some more discussion about precise details. RESOLVED: Change the animation model to snapshot much less properties. Details of exactly what snapshotting is left TBD. mismatched grid-template strings -------------------------------- <plinss> http://lists.w3.org/Archives/Public/www-style/2012Mar/0418.html PhilCupp: I can speak to this. PhilCupp: What happens when strings are shorter than other? PhilCupp: We could consider extending the last character until they're equal length. PhilCupp: But that can create non-rectangular grid cells. PhilCupp: So I suggest we just pad it with empty cells. PhilCupp: I think Bert just responded with the same suggestion. PhilCupp: The second discussion was about non-rectangular regions. PhilCupp: I think there was agreement that it would be useful, but we don't want to add it to the current level of the spec. TabAtkins: I agree with both of these. antonp: For shorter strings, I'd prefer them to be invalid. PhilCupp: We could do that too. antonp: I think it's good to encourage typing out the periods when you want empty cells, to make it more readable. vhardy: agree with antonp plinss: Then we could in the future decide to make mismatched string lengths pad out the last cell, even if it's a non-rectangular region. PhilCupp: I'm okay with that. RESOLVED: Treat both mismatched string lengths and non-rectangular regions as illegal syntax in Grid. -webkit-mask ------------ glazou: The WG needs to discuss this because of the f2f discussions in paris. glazou: I spent roughly 20 minutes today looking for sites using this in production. It's spreading fast. <fantasai> http://robert.ocallahan.org/2008/06/applying-svg-effects-to-html-content_04.html glazou: I'd like to avoid the clash we had in Paris for other properties. glazou: I heard the message from one browser vendor that the chairs didn't jump on the properties implemented by one browser and spreading, so let's do this. fantasai: We had a discussion about these properties before, and our conclusion was not to have new properties for masking and reflection, but rather to use the existing SVG properties for this. ChrisL: Agreed. Looking at this blog post, it seems Maciej didn't like or understand them. ChrisL: And we can extend this in the future. ChrisL: Such as using one color channel in an image, or something like that. ChrisL: So using SVG's seems to be a more workable approach and has a longer implementation history. glazou: There's a trend about webkit-mask today. ChrisL: But if we do this now, SVG will have to support both of them now. ChrisL: We've had this confusion before, and we'd like to avoid it if possible. plinss: We do need to address this problem, but not necessarily by importing the Webkit properites per se. <fantasai> plinss++ vhardy: Some of the uses I saw was people using masks to fill text with a gradient. Is that what you saw? glazou: Most of what I saw was masks on images. mollydotcom: Once again we see a webkit property proliferating, so I agree with Daniel that we need to address it. Just saying "here's SVG" won't win the day. mollydotcom: We should sync with SVG, but the demand is already here and needs syntax that people understand (CSS, not SVG). <glazou> +1 <glazou> unfortunately fantasai: The proposal isn't "Use SVG". The proposal is to take a property that SVG already has and say "you can use it on HTML too", instead of inventing a new property that does almost exactly the same thing. <vhardy> fantasai++ <smfr> applying a mask should not require typing angle brackets mollydotcom: Once the precedent is widely created, how do we turn back? <smfr> what is the proposal? <fantasai> http://people.mozilla.com/~roc/SVG-CSS-Effects-Draft.html ChrisL: You don't need to point to SVG. The property lets you point to an image. <JohnJansen> I think this boils down to something being implemented in webkit, but no one brings that to the WG to get it standardized. It would be good to have a process other than "I've heard of this new thing in webkit..." Who owns bringing something to the WG? <mollydotcom> thanks john for saying what I couldn't articulate <fantasai> JohnJansen: it was brought to the WG. And the WG decided to go with roc's approach. <fantasai> JohnJansen: but nothing happened, so now people are panicking <sylvaing> JohnJansen: yes, this is not a new random thing. <JohnJansen> fantasai, sylvaing: I realize that... where is the proposal, though? <sylvaing> John: see links posted above <dbaron> and then there's also http://www.w3.org/TR/2012/WD-css3-images-20120112/#element-reference <dbaron> which we just decided to remove <smfr> dbaron: that's certainly relevant for reflections <dbaron> smfr, yes <fantasai> dbaron: we didn't decide to remove it, we decided to defer it krit: 'mask' actually needs to point to a <mask> element. TabAtkins: And that's not cool. :/ ChrisL: We could use the same simplifying technique we used with 'filter' to make it CSS-friendly. plinss: In general that's okay. plinss: So could someone propose a clean CSS syntax for this? hober: I can write up what webkit currently does, but I'm not sure I'm the best person to harmonize with SVG. TabAtkins and vhardy: We can help. glazou: And reflections? dbaron: We had something - the element() value - that would have allowed reflections, but we decided to defer it a few weeks ago. Meeting closed.Received on Wednesday, 11 April 2012 20:12:37 UTC
This archive was generated by hypermail 2.3.1 : Monday, 2 May 2016 14:38:57 UTC


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Zynga will continue to delve into licensed IP for its casual mobile games in the coming year, and is focusing on two hefty names to do it: Harry Potter, and Game of Thrones.
According to Zynga's latest financial report, the company will invested in licensed games for both franchises for release in 2019.
The first, a Harry Potter match-3 title, will be licensed through Warner Bros. Interactive Entertainment. The second, a Game of Thrones social casino slots game, goes through HBO. An additional Game of Thrones title is also in the works.
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Welcome to Living Above
The Influence in Dane County WI.
Narcotics are addictive drugs that reduce the user's perception of pain and induce euphoria (a feeling of exaggerated and unrealistic well-being). The English word narcotic is derived from the Greek narkotikos , which means "numbing" or "deadening." Although the term can refer to any drug that deadens sensation or produces stupor, it is commonly applied to the opioids that is, to all natural or synthetic drugs that act like morphine.
The central nervous system in humans and other mammals contains five different types of opioid receptor proteins, located primarily in the brain, spinal cord, and digestive tract. When a person takes an opioid medication, the drug attaches to these opioid receptors in the brain and spinal cord and decreases the person's perception of pain. Narcotics do not, however, reduce or eliminate the cause of the pain.
Some of the opioid receptors (known as mu and sigma receptors) influence a person's perception of pleasure. When a narcotic medication stimulates these receptor proteins, the person typically experiences intense sensations of euphoria or well-being. The speed with which these drugs take effect depends on the method of administration; IV narcotics reach their peak effectiveness within ten minutes, while oral narcotics take about an hour and a half, and skin patches take between two and four hours.
Overdoses of narcotics can cause drowsiness, unconsciousness, and even death because these drugs suppress respiration.
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ISIS Propaganda Video Puts NYC On High Alert
An attack similar to the Paris attack last week is targeted at in New York; this is the contents of the Islamic State video. This propaganda video threatens an attack on the New York City, informs officials on Thursday. Though the legitimacy of the video is not verified and the officials have not received any


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