text:
- Research
- Open Access
Complete remission after first-line radio-chemotherapy as predictor of survival in extranodal NK/T cell lymphoma
© Chauchet et al.; licensee BioMed Central Ltd. 2012
- Received: 22 April 2012
- Accepted: 8 June 2012
- Published: 8 June 2012
Extranodal nasal-type NK/T-cell lymphoma is a rare and severe disease. Considering the rarity of this lymphoma in Europe, we conducted a multicentric retrospective study on nasal-type NK/T cell lymphoma to determine the optimal induction strategy and identify prognostic factors.
Thirty-six adult patients with nasal-type NK/T-cell lymphoma were recruited and assessed. In total, 80 % of patients were classified as having upper aerodigestive tract NK/T-cell lymphoma (UNKTL) and 20 % extra-upper aerodigestive tract NK/T-cell lymphoma (EUNKTL).
For advanced-stage disease, chemotherapy alone (CT) was the primary treatment (84 % vs. 10 % for combined CT + radiation therapy (RT), respectively), while for early-stage disease, 50 % of patients received the combination of CT + RT and 50 % CT alone. Five-year overall survival (OS) and progression-free survival (PFS) rates were 39 % and 33 %. Complete remission (CR) rates were significantly higher when using CT + RT (90 %) versus CT alone (33 %) (p < 0.0001). For early-stage disease, CR rates were 37 % for CT alone versus 100 % for CT + RT. Quality of response was significantly associated with survival, with 5-year OS being 80 % for CR patients versus 0 % for progressive disease patients (p < 0.01).
Early RT concomitantly or sequentially with CT led to improved patient outcomes, with quality of initial response being the most important prognosticator for 5-year OS.
- Extra nodal NK/T cell
- Radiotherapy plus chemotherapy
- Complete response
- KPI index
Extranodal nasal-type NK/T-cell lymphoma is a rare and severe disease, occurring more frequently in Asia and South America than in Europe and North America [1–4]. This type of disease represents a distinct entity among T-cell lymphomas according to the World Health Organization (WHO) classification, [5] being found in both the nasal cavity and extranasal sites [6–8]. The disease is characterized histologically by the local invasion and necrosis of natural killer (NK) cells or T-cells with an invariable Epstein-Barr virus (EBV) infection. In published studies involving adults with a median age of 50 years, 60-90 % of lymphomas were localized in the nasal and upper airway regions, with the remaining found in extranasal sites [2, 9, 10]. Due to the low incidence of the disease, only a few randomized controlled trials have been undertaken [11–13]. Previous studies showed that 5-year overall survival (OS) rates were less than 40 %, with progression usually occurring within 2 years [2, 7, 9–15]. However, the early use of sequential radiotherapy (RT) and chemotherapy (CT) for localized nasal NK/T-cell [13, 16] lymphoma was shown to be a successful therapy, which cured approximately half of patients [1, 17]. In most patients with advanced disease (stage III/IV), the clinical course is highly aggressive, with frequent CT resistance and poor outcome. CHOP-based therapy [18, 19] was often used, but associated without satisfactory results. However, recent combination therapies involving L-asparaginase have improved the outcome in high-risk, refractory, or relapsed patients [20–22]. The optimal therapy for advanced-stage or relapsed and refractory disease is yet to be established, although the results of several recent prospective trials showed improved results using CT or CT + RT [20, 23–25]. Considering the rarity of this lymphoma in Europe, we conducted a multicentric retrospective study on nasal-type NK/T cell lymphoma. To this end, we reviewed the clinical and biological characteristics as well as treatments of 36 patients, with outcomes analyzed according to disease responses in order to determine the optimal induction strategy and identify prognostic factors.
Patient characteristics
Clinical characteristics of the 36 patients diagnosed with NK/T cell lymphoma 'nasal type'
Number of patients
Median age (years ; range)
49 (22–80)
Age > 60 years, n (%)
9 (25)
Gender (male – female)
24 – 11
WHO performance status, n (%)
0- 1
27 (75)
6 (17)
3 (8)
Local invasiveness in Upper NK / T lymphoma: T3 and T4, n (%)
21 (72)
Signs and symptoms, n (%)
Purulent rhinorrhea
20 (55)
Nasal obstruction or edema
25 (69)
12 (33)
11 (30)
5 (14)
Orbital edema or uveitis
5 (14)
2 (5)
Nerve VII, palsy
2 (5)
B symptoms, n (%)
14 (39)
Anatomic category, n (%)
Upper NK/T lymphoma
29 (80)
Extra upper NK/T lymphoma
7 (20)
Sites of localization, n (%)
25 (69)
Paranasal sinus
21 (58)
16 (44)
Palate – pharyngeal
9 (25)
Bone marrow
8 (22)
4 (11)
4 (11)
4 (11)
Central nervous involvement
4 (11)
4 (11)
Gastrointestinal tract
3 (8)
2 (5)
1 (3)
Suprarenal gland
Regional lymphadenopathy, n (%)
16 (44)
Biology, n (%)
LDH > Upper limit of normal
14 (39)
22 (61)
B2 microglobuline > upper limit of normal
21 (58)
CRP > upper limit of normal
18 (50)
13 (36)
Serum albumin <30 mg/L
12 (33)
Hemophagocytic syndrome, n (%)
3 (8)
Ann Arbor staging, n (%)
10 (28)
6 (17)
20 (55)
IPI score, n (%)
0 – 1 (low risk)
16 (44)
2 (low intermediate risk)
7 (20)
3 (high intermediate risk)
7 (20)
4 -5 (high risk)
6 (16)
Korean NK/T cell prognostic index, n (%)
0 (low risk)
5 (14)
1 (low intermediate risk)
14 (39)
2 (high intermediate risk)
8 (22)
3 – 4 (high risk)
9 (25)
PIT score, n (%)
0 (low risk)
13 (37)
1 (low intermediate)
11 (31)
2 (high intermediate risk)
8 (22)
3 – 4 (high risk)
3 (8)
Treatment modalities
First line treatment of the patients with T/NK cell lymphoma
Number of patients n (%)
Stage I -II n (%)
Stage IV n(%)
UNKTL n (%)
EUNKTL n (%)
First line therapy
36 (100)
16 (45)
20 (55)
29 (80)
7 (20)
Chemotherapy alone
25 (69)
8 (50)
17 (85)
18 (62)
7 (100)
Chemotherapy + radiotherapy
10 (28)
8 (50)
2 (10)
10 (35)
Radiotherapy alone
1 (3)
1 (5)
1 (3)
Anthracycline-based regimen
26 (74)
11 (69)
15 (79)
20 (71)
6 (86)
High-dose methotrexate + high-dose aracytine regimen
4 (11)
2 (12)
2 (11)
3 (11)
1 (14)
High-dose methotrexate + L-asparaginase
2 (6)
1 (7)
1 (5)
2 (7)
Cisplatin-based regimen
3 (9)
2 (12)
1 (5)
3 (11)
Radiation therapy and modalities
Ten patients received CT + RT. The RT was given with a median dose of 40 gray (40 to 46). Only one patient received RT alone (30 gray) plus corticosteroids because of advaned age and comorbidities.
Response to treatment
At the end of treatment, complete remission (CR) was observed in 48 % of patients, while the remaining 52 % experienced partial response or progressive disease. For the entire cohort, CR rates were 33 % for CT alone compared with 90 % for RT + CT.. In the CT group, there was no significant difference (p = 0.77) in CR rates according to the type of regimen: 52 % of patients achieved CR with an anthracycline-based regimen, 66 % with the combination of methotrexate and L-asparaginase, and 34 % with cisplatin-based regimens
For UNKTL patients, CR rates were only 50 % for CT alone versus 90 % for RT + CT.. However, UNKTL patients with CT + RT have more favorable prognostic parameters than CT alone patients: 20 % stage IV versus 61 %, 10 % of elevated LDH versus 44 %; but the same percentage of local invasiveness and regional lymphadenopathy involved (70 % vs 67 % and 40 % vs 44 %, respectively). One patient received RT alone, but experienced disease progression on this regimen.
Among the low stage group (stage I-II), the distribution between the two treatment modalities is balanced confirming the better outcome with the combination CT + RT. However in the stage IV patients, the difference in the distribution between CT and CT + RT could create a significant bias in favor of the CT + RT group.
Response rate after first line therapy in patient with NK/T lymphoma
All patients
First line therapy
Chemotherapy alone
Chemotherapy + radiotherapy
Radiotherapy alone
Stage I and II
Chemotherapy alone
Chemotherapy + radiotherapy
Stage IV
Chemotherapy alone
Chemotherapy + radiotherapy
Radiotherapy alone
Chemotherapy alone
Chemotherapy + radiotherapy
Radiotherapy alone
Chemotherapy alone
Overall survival and progression-free survival
Extranodal nasal-type NK/T-cell lymphoma is considered a distinct clinicopathological entity according to the WHO classification of lymphoid tumors, being more frequent in Asia and Central and South America than in Western countries [2, 3, 5, 9, 17, 26]. In a recent international multicenter study reported by the International Peripheral T-cell Lymphoma Project, median survival time for patients with NK/T-cell lymphoma was 8 months, being the worst among all peripheral T-cell lymphomas included in the study [17]. To date, only a few studies have compared the clinical and pathologic features of patients with nasal or extranasal disease [7, 10, 17].
In our study, 36 French patients, all of European descent, observed over a 22-year period were diagnosed with nasal-type NK/T cell lymphoma..Main patient characteristics, such as age, sex ratio, B symptoms, and clinical aspects of the disease, were comparable to those previously reported [17, 27, 28]. At diagnosis, 80 % of tumors involved the upper aerodigestive tract, including the nasal and oral cavity, as well as the naso-, oro- and hypopharynx, while 20 % were extranasal. Disease presentation in our population was aggressive, with 65 % of UNKTL patients presenting stage IV at diagnosis. Although extranasal cases presented more adverse clinical features, no statistical differences were found in terms of OS or PFS between UNKTL and EUNKTL patients. This absence in OS difference may be accounted for by the more advanced disease stage of the UNKTL population. Previous studies reported bone marrow and central nervous system involvement at presentation to be rare, affecting 3 % and 7 % of cases, respectively [8, 29–31]. In our study, however, bone marrow and central nervous system involvement was observed in 22 % and 11 % of patients, respectively. However, regional node involvement was found to be more frequent, affecting 44 % of patients [32, 33]. In line with previous studies, we identified several variables associated with poor survival, notably regional lymph node involvement [34], local invasiveness [34–37], elevated lactate deshydrogenase [1, 34], poor performance status [1], and B symptoms [1, 37, 38].
Several staging systems have been proposed in respect to nasal NK/T-cell lymphoma in order to predict prognosis. The Ann-Arbor staging system, while designed mainly for Hodgkin lymphoma, is not always accurate in the case of NK-cell lymphomas. In a number of studies on nasal NK-cell lymphoma, the involvement of areas outside the nasal cavity, including the paranasal sinuses, nasopharynx, and orbits, was defined as stage IE disease. In this case, the Ann-Arbor staging system cannot be used to determine the extent of the disease. Thus, for our patients, we scored local invasiveness greater than or equal to T3 according to the TNM classification. Overall, 72 % of UNKTL patients had a local invasiveness > T3, which was associated with worse survival.
Several studies investigated the impact of IPI in patients with nasal NK/T-cell lymphoma [7, 9, 13]. However, the use of this index has been controversial [13, 34, 39, 40], as in a number of studies, only a small proportion of NK/T-cell lymphoma patients (up to 7 %) were categorized as high-risk [1, 13, 34, 41, 42]. Assigning a conventional IPI score appears to be of limited value, since most cases of NK/T-cell lymphomas are localized and result in a low score, despite survival being poor.
Lee et al. [9] developed the KPI, a prognostic model based on four risk factors: B symptoms, advanced stage, elevated lactate dehydrogenase levels, and involvement of regional lymph nodes. When analyzed according to the number of risk factors, the 5-year OS rate was 81 % for patients with no risk factors (score 0) and 7-15 % for those with three to four (scores 3–4). Our data validated the prognostic impact of the KPI, with 5-year OS rates being 60 % for patients with score 0 versus 17 % for those with score 4. This index appears more accurate than the IPI score in distinguishing high-risk groups, potentially being the most appropriate prognostic scoring system for patients with nasal-type NK/T lymphoma [43].
There are currently a few randomized trials evaluating the different therapeutic options for nasal-type NK/T-cell lymphomas. The majority of studies are retrospective in nature and almost all are conducted in the geographical areas where the tumor is prevalent. Most authors reported on the use of RT alone or combined with CT, with RT being associated with high remission rates and prolonged survival, mainly in the case of localized disease [34, 40, 44, 45]. In a study of 82 patients with localized disease, early RT was shown to be the only independent prognostic factor, with 5-year OS being significantly better in patients receiving >54 Gy [46]. There appears to be a consensus that the optimal dose is 50 Gy, to be delivered to both the nasal cavity and sinuses. Nevertheless, concurrent CT may improve both local and systemic disease control. When comparing CT alone to RT alone or CT + RT, CR rates were significantly higher in patients treated with CT + RT [13, 28, 34, 44, 47]. In addition, two recent reports on CT + RT for localized disease (stage IE to IIE) showed improved results compared to the historical controls using RT alone [24, 48].
In our study, the overall response rate was 48 %, with progressive disease observed in 52 % of patients and no partial response. Combined therapy comprising RT and anthracycline-based CT regimens was associated with higher CR rates and longer OS compared to CT or RT alone, even in advanced-stage disease (CR rate of 31 % vs 50 % for CT and CT + RT, respectively). However, the CT + RT cohort has a better prognostic profile than the CT population and this difference will create a significant bias in favor of CT + RT group, especially for this high stage group. No CR was recorded for RT alone, although this treatment was only administered to one elderly patient with a non optimal dose of 40 Gy. In the two published metaanalyses, first-line CT regimens involved CHOP, CHOP-like schedules, etoposide, ifosfamide, or cisplatin. In our study, however, the disease did not respond well to these combinations. The introduction of L-asparaginase-containing regimens led to further improvements, as most studies using asparaginase-based regimens in a relapsed or refractory setting reported response rates of around 50 %, with 5-year OS being 65 % (86 % for localized disease and 38 % for advanced stage) [20, 22, 25, 48–50]. In our study, the different CT regimens were compared, with no statistical difference (but low numbers of patients in each type) found in CR rates according to the type of regimen. The use of L-asparaginase-based regimens in induction therapy did not improve CR rates, although only four patients were administered this regimen. Data regarding the use of L-asparaginase as first-line therapy is therefore still needed.
For all patients, 5-year OS and PFS rates were 39 % and 33 %, respectively. In addition, the quality of response after first-line treatment was found to be crucial for survival, with 5-year OS being 80 % in CR patients compared to 0 % in progressive disease patients.
In our study, the early use of RT concomitantly or sequentially with CT was shown to improve patient outcome, especially in the case of localized disease, and even in patients presenting aggressive forms. Based on these positive results, patients with localized disease should be administered RT + CT. The use of L-asparaginase-based regimens as first-line therapy should be considered for patients with disseminated disease, although prospective trials are still needed to confirm improved survival rates associated with this therapeutic approach.
Patients and Methods
Patients and staging evaluation
Between January 1989 and September 2010, 36 patients were recruited in seven hematological centers in France. All the patients in this series been entirely of European descent (no patients were of Asia or south America descent). Patients were required to fulfill the WHO criteria for clinicopathologic diagnosis and classification of NK/T-cell lymphoma [5]. All biopsied tissues were critically reviewed. The following data was collected: gender, age, clinical characteristics (performance status and symptoms), biological parameters (lactate dehydrogenase, C-reactive protein [CRP], and serum albumin), radiological presentation, and histopathological reports describing angiocentricity, angioinvasion, necrosis zones, and polymorphism of individual cells. Immunohistochemical studies had to be positive for NK/T-cell markers, including CD2, CD3, or CD56 cytotoxic molecule (TIA-1 or granzyme B), and for EBV-encoded small RNA, and negative for B-cell markers, such as CD20 or CD79. Patients with blastic NK-cell lymphoma/leukemia, aggressive NK-cell lymphoma/leukemia, and unspecified peripheral T-cell lymphoma were excluded from the analysis. Scores for the International Prognostic Index [51] (IPI), Korean Prognostic Index (KPI) [9], and Prognostic Index for PTCL/NOS [52] (PIT) were calculated for all patients. We separately analyzed the survival of patients with upper aerodigestive tract NK/T-cell lymphoma (UNKTL) and extra-upper aerodigestive tract NK/T-cell lymphoma (EUNKTL) [1, 27]. UNKTL included all lymphomas confined to the nasal cavity, nasopharynx, and upper aerodigestive tract, whereas lymphomas at all other sites were considered to be EUNKTL. Patients with primary lesions within the nasal cavity and secondary lesions in other organs were classified as UNKTL. Local invasiveness was defined in accordance with the 2002 TNM classification of the American Joint Committee on Cancer [9].
Outcomes and treatment strategies
CT schedules, RT dosages, and chronological sequence of treatments were analyzed for each patient. In terms of CT, treatments were based on anthracycline, aracytine or cisplatin regimens (doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone [ACVBP]) for 17 (49 %) patients; cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) for 9 (25 %) patients; cyclophosphamide, vincristine, prednisone, doxorubicin, and methotrexate (COPADM) followed by cyclophosphamide, cytosine arabinoside, and etoposide (CYVE) for four (11 %) patients; etoposide, methylprednisolone, cytosine arabinoside, and cisplatin (ESHAP) and dexamethasone (DHAP) for 3 (8.3 %) patients; high-dose methotrexate plus L-asparaginase for 2 (6 %) patients. Autologous bone marrow transplantation was performed as first-line consolidation on one patient. The different treatment schedules are listed in Table 2. Studied outcomes were treatment response, progression-free survival (PFS), and OS, with treatment response being evaluated at the end of treatment according to the standardized response criteria of Cheson et al.[53].
Regarding RT treatment, the median dose was 40 grays (Gy). All patients received RT from a linear accelerator with 4 megavolt (MV), 6 MV or 10 MV photons to achieve dose homogeneity. Generally, the planning target volume included all macroscopic lesions, the paranasalsinuses, the nasopharynx, the upper gum, and the palate with adequate margins. Regardless of primary tumor localization, elective cervical lymph node irradiation was not delivered unless the neck was involved clinically. The most common field arrangement was two lateral opposing photons fields with supplementation between the medial canthus by appropriate energy of electron.
Statistical analysis
OS and PFS were estimated using the Kaplan-Meier product-limit method. OS was measured from the date of diagnosis to death or last follow-up visit. Unadjusted Cox proportional hazards models were employed to make group comparisons for baseline and treatment characteristics and Kaplan –Meier curves were used to quantify the percentage of patients who were free of recurrence or those who stay alive over time. A p-value <0.05 was considered statistically significant, with two-sided significance tests used for all p-values.
Authors' Affiliations
- Lee J, Park YH, Kim WS, Lee SS, Ryoo BY, Yang SH, Park KW, Kang JH, Park JO, Lee SH: Extranodal nasal type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy. Eur J Cancer. 2005, 41: 1402-1408. 10.1016/j.ejca.2005.03.010.View ArticlePubMedGoogle Scholar
- Oshimi K, Kawa K, Nakamura S, Suzuki R, Suzumiya J, Yamaguchi M, Kameoka J, Tagawa S, Imamura N, Ohshima K: NK-cell neoplasms in Japan. Hematology. 2005, 10: 237-245. 10.1080/10245330400026162.View ArticlePubMedGoogle Scholar
- Quintanilla-Martinez L, Franklin JL, Guerrero I, Krenacs L, Naresh KN, Rama-Rao C, Bhatia K, Raffeld M, Magrath IT: Histological and immunophenotypic profile of nasal NK/T cell lymphomas from Peru: high prevalence of p53 overexpression. Hum Pathol. 1999, 30: 849-855. 10.1016/S0046-8177(99)90147-8.View ArticlePubMedGoogle Scholar
- Rudiger T, Weisenburger DD, Anderson JR, Armitage JO, Diebold J, MacLennan KA, Nathwani BN, Ullrich F, Muller-Hermelink HK: Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the Non-Hodgkin's Lymphoma Classification Project. Ann Oncol. 2002, 13: 140-149. 10.1093/annonc/mdf033.View ArticlePubMedGoogle Scholar
- Chan JK, Quintanilla-Martinez L, Ferry JA, Peh SC: Extranodal NK/T-cell lymphoma, nasal type. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Edited by: Swerdlow SH, Campo E, Harris NL. 2008, International Agency for Research on Cancer, Lyon, FranceGoogle Scholar
- Jaffe ES, Krenacs L, Raffeld M: Classification of cytotoxic T-cell and natural killer cell lymphomas. Semin Hematol. 2003, 40: 175-184. 10.1016/S0037-1963(03)00132-X.View ArticlePubMedGoogle Scholar
- Lim ST, Hee SW, Quek R, Lim LC, Yap SP, Loong EL, Sng I, Tan LH, Ang MK, Ngeow J: Comparative analysis of extra-nodal NK/T-cell lymphoma and peripheral T-cell lymphoma: significant differences in clinical characteristics and prognosis. Eur J Haematol. 2008, 80: 55-60.PubMedGoogle Scholar
- Oshimi K: Progress in understanding and managing natural killer-cell malignancies. Br J Haematol. 2007, 139: 532-544. 10.1111/j.1365-2141.2007.06835.x.View ArticlePubMedGoogle Scholar
- Lee J, Suh C, Park YH, Ko YH, Bang SM, Lee JH, Lee DH, Huh J, Oh SY, Kwon HC: Extranodal natural killer T-cell lymphoma, nasal-type: a prognostic model from a retrospective multicenter study. J Clin Oncol. 2006, 24: 612-618. 10.1200/JCO.2005.04.1384.View ArticlePubMedGoogle Scholar
- Pagano L, Gallamini A, Trape G, Fianchi L, Mattei D, Todeschini G, Spadea A, Cinieri S, Iannitto E, Martelli M: NK/T-cell lymphomas 'nasal type': an Italian multicentric retrospective survey. Ann Oncol. 2006, 17: 794-800. 10.1093/annonc/mdl015.View ArticlePubMedGoogle Scholar
- Kwong YL, Anderson BO, Advani R, Kim WS, Levine AM, Lim ST: Management of T-cell and natural-killer-cell neoplasms in Asia: consensus statement from the Asian Oncology Summit 2009. Lancet Oncol. 2009, 10: 1093-1101. 10.1016/S1470-2045(09)70265-7.View ArticlePubMedGoogle Scholar
- Bossard C, Belhadj K, Reyes F, Martin-Garcia N, Berger F, Kummer JA, Briere J, Baglin AC, Cheze S, Bosq J: Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials. Blood. 2007, 109: 2183-2189. 10.1182/blood-2006-07-033142.View ArticlePubMedGoogle Scholar
- Chim CS, Ma SY, Au WY, Choy C, Lie AK, Liang R, Yau CC, Kwong YL: Primary nasal natural killer cell lymphoma: long-term treatment outcome and relationship with the International Prognostic Index. Blood. 2004, 103: 216-221. 10.1182/blood-2003-05-1401.View ArticlePubMedGoogle Scholar
- Ng SB, Lai KW, Murugaya S, Lee KM, Loong SL, Fook-Chong S, Tao M, Sng I: Nasal-type extranodal natural killer/T-cell lymphomas: a clinicopathologic and genotypic study of 42 cases in Singapore. Mod Pathol. 2004, 17: 1097-1107. 10.1038/modpathol.3800157.View ArticlePubMedGoogle Scholar
- Yong W, Zheng W, Zhang Y, Zhu J, Wei Y, Zhu D, Li J: L-asparaginase-based regimen in the treatment of refractory midline nasal/nasal-type T/NK-cell lymphoma. Int J Hematol. 2003, 78: 163-167. 10.1007/BF02983387.View ArticlePubMedGoogle Scholar
- Isobe K, Uno T, Tamaru J, Kawakami H, Ueno N, Wakita H, Okada J, Itami J, Ito H: Extranodal natural killer/T-cell lymphoma, nasal type: the significance of radiotherapeutic parameters. Cancer. 2006, 106: 609-615. 10.1002/cncr.21656.View ArticlePubMedGoogle Scholar
- Au WY, Weisenburger DD, Intragumtornchai T, Nakamura S, Kim WS, Sng I, Vose J, Armitage JO, Liang R: Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project. Blood. 2009, 113: 3931-3937. 10.1182/blood-2008-10-185256.View ArticlePubMedGoogle Scholar
- Kwong YL, Chan AC, Liang R, Chiang AK, Chim CS, Chan TK, Todd D, Ho FC: CD56+ NK lymphomas: clinicopathological features and prognosis. Br J Haematol. 1997, 97: 821-829. 10.1046/j.1365-2141.1997.1462962.x.View ArticlePubMedGoogle Scholar
- Suzuki R, Suzumiya J, Yamaguchi M, Nakamura S, Kameoka J, Kojima H, Abe M, Kinoshita T, Yoshino T, Iwatsuki K: Prognostic factors for mature natural killer (NK) cell neoplasms: aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type. Ann Oncol. , 21: 1032-1040.Google Scholar
- Jaccard A, Gachard N, Marin B, Rogez S, Audrain M, Suarez F, Tilly H, Morschhauser F, Thieblemont C, Ysebaert L: Efficacy of L-asparaginase with methotrexate and dexamethasone (AspaMetDex regimen) in patients with refractory or relapsing extranodal NK/T-cell lymphoma, a phase 2 study. Blood. 2011, 117: 1834-1839. 10.1182/blood-2010-09-307454.View ArticlePubMedGoogle Scholar
- Jaccard A, Petit B, Girault S, Suarez F, Gressin R, Zini JM, Coiteux V, Larroche C, Devidas A, Thieblemont C: L-asparaginase-based treatment of 15 western patients with extranodal NK/T-cell lymphoma and leukemia and a review of the literature. Ann Oncol. 2009, 20: 110-116.View ArticlePubMedGoogle Scholar
- Yong W, Zheng W, Zhu J, Zhang Y, Wang X, Xie Y, Lin N, Xu B, Lu A, Li J: L-asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type. Ann Hematol. 2009, 88: 647-652. 10.1007/s00277-008-0669-3.View ArticlePubMedGoogle Scholar
- Girinsky T, Lapusan S, Ribrag V, Koscielny S, Ferme C, Carde P: Phase II study of concomitant chemoradiotherapy in bulky refractory or chemoresistant relapsed lymphomas. Int J Radiat Oncol Biol Phys. 2005, 61: 476-479. 10.1016/j.ijrobp.2004.06.210.View ArticlePubMedGoogle Scholar
- Kim SJ, Kim K, Kim BS, Kim CY, Suh C, Huh J, Lee SW, Kim JS, Cho J, Lee GW: Phase II trial of concurrent radiation and weekly cisplatin followed by VIPD chemotherapy in newly diagnosed, stage IE to IIE, nasal, extranodal NK/T-Cell Lymphoma: Consortium for Improving Survival of Lymphoma study. J Clin Oncol. 2009, 27: 6027-6032. 10.1200/JCO.2009.23.8592.View ArticlePubMedGoogle Scholar
- Kwong YL, Yamaguchi M, Maeda Y: Phase II study of SMILE chemothearpy for newly-diagnosed stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type: NKTSG study. Haematologica., 95.Google Scholar
- Barrionuevo C, Zaharia M, Martinez MT, Taxa L, Misad O, Moscol A, Sarria G, Guerrero I, Casanova L, Flores C, Zevallos-Giampietri EA: Extranodal NK/T-cell lymphoma, nasal type: study of clinicopathologic and prognosis factors in a series of 78 cases from Peru. Appl Immunohistochem Mol Morphol. 2007, 15: 38-44. 10.1097/01.pai.0000205062.27174.56.View ArticlePubMedGoogle Scholar
- Lee J, Kim WS, Park YH, Park SH, Park KW, Kang JH, Lee SS, Lee SI, Lee SH, Kim K: Nasal-type NK/T cell lymphoma: clinical features and treatment outcome. Br J Cancer. 2005, 92: 1226-1230. 10.1038/sj.bjc.6602502.PubMed CentralView ArticlePubMedGoogle Scholar
- Li CC, Tien HF, Tang JL, Yao M, Chen YC, Su IJ, Hsu SM, Hong RL: Treatment outcome and pattern of failure in 77 patients with sinonasal natural killer/T-cell or T-cell lymphoma. Cancer. 2004, 100: 366-375. 10.1002/cncr.11908.View ArticlePubMedGoogle Scholar
- Kim GE, Cho JH, Yang WI, Chung EJ, Suh CO, Park KR, Hong WP, Park IY, Hahn JS, Roh JK, Kim BS: Angiocentric lymphoma of the head and neck: patterns of systemic failure after radiation treatment. J Clin Oncol. 2000, 18: 54-63.PubMedGoogle Scholar
- Vose J, Armitage J, Weisenburger D: International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol. 2008, 26: 4124-4130.View ArticlePubMedGoogle Scholar
- Wong KF, Chan JK, Cheung MM, So JC: Bone marrow involvement by nasal NK cell lymphoma at diagnosis is uncommon. Am J Clin Pathol. 2001, 115: 266-270. 10.1309/E5PR-6A9R-Q02N-8QVW.View ArticlePubMedGoogle Scholar
- Kim TM, Lee SY, Jeon YK, Ryoo BY, Cho GJ, Hong YS, Kim HJ, Kim SY, Kim CS, Kim S: Clinical heterogeneity of extranodal NK/T-cell lymphoma, nasal type: a national survey of the Korean Cancer Study Group. Ann Oncol. 2008, 19: 1477-1484. 10.1093/annonc/mdn147.View ArticlePubMedGoogle Scholar
- Li YX, Liu QF, Fang H, Qi SN, Wang H, Wang WH, Song YW, Lu J, Jin J, Wang SL: Variable clinical presentations of nasal and Waldeyer ring natural killer/T-cell lymphoma. Clin Cancer Res. 2009, 15: 2905-2912. 10.1158/1078-0432.CCR-08-2914.View ArticlePubMedGoogle Scholar
- You JY, Chi KH, Yang MH, Chen CC, Ho CH, Chau WK, Hsu HC, Gau JP, Tzeng CH, Liu JH: Radiation therapy versus chemotherapy as initial treatment for localized nasal natural killer (NK)/T-cell lymphoma: a single institute survey in Taiwan. Ann Oncol. 2004, 15: 618-625. 10.1093/annonc/mdh143.View ArticlePubMedGoogle Scholar
- Li YX, Coucke PA, Li JY, Gu DZ, Liu XF, Zhou LQ, Mirimanoff RO, Yu ZH, Huang YR: Primary non-Hodgkin's lymphoma of the nasal cavity: prognostic significance of paranasal extension and the role of radiotherapy and chemotherapy. Cancer. 1998, 83: 449-456. 10.1002/(SICI)1097-0142(19980801)83:3<449::AID-CNCR13>3.0.CO;2-W.View ArticlePubMedGoogle Scholar
- Logsdon MD, Ha CS, Kavadi VS, Cabanillas F, Hess MA, Cox JD: Lymphoma of the nasal cavity and paranasal sinuses: improved outcome and altered prognostic factors with combined modality therapy. Cancer. 1997, 80: 477-488. 10.1002/(SICI)1097-0142(19970801)80:3<477::AID-CNCR16>3.0.CO;2-U.View ArticlePubMedGoogle Scholar
- Robbins KT, Fuller LM, Vlasak M, Osborne B, Jing BS, Velasquez WS, Sullivan JA: Primary lymphomas of the nasal cavity and paranasal sinuses. Cancer. 1985, 56: 814-819. 10.1002/1097-0142(19850815)56:4<814::AID-CNCR2820560419>3.0.CO;2-P.View ArticlePubMedGoogle Scholar
- Kim WS, Song SY, Ahn YC, Ko YH, Baek CH, Kim DY, Yoon SS, Lee HG, Kang WK, Lee HJ: CHOP followed by involved field radiation: is it optimal for localized nasal natural killer/T-cell lymphoma?. Ann Oncol. 2001, 12: 349-352. 10.1023/A:1011144911781.View ArticlePubMedGoogle Scholar
- Aviles A, Diaz NR, Neri N, Cleto S, Talavera A: Angiocentric nasal T/natural killer cell lymphoma: a single centre study of prognostic factors in 108 patients. Clin Lab Haematol. 2000, 22: 215-220. 10.1046/j.1365-2257.2000.00307.x.View ArticlePubMedGoogle Scholar
- Cheung MM, Chan JK, Lau WH, Ngan RK, Foo WW: Early stage nasal NK/T-cell lymphoma: clinical outcome, prognostic factors, and the effect of treatment modality. Int J Radiat Oncol Biol Phys. 2002, 54: 182-190.View ArticlePubMedGoogle Scholar
- Cheung MM, Chan JK, Lau WH, Foo W, Chan PT, Ng CS, Ngan RK: Primary non-Hodgkin's lymphoma of the nose and nasopharynx: clinical features, tumor immunophenotype, and treatment outcome in 113 patients. J Clin Oncol. 1998, 16: 70-77.PubMedGoogle Scholar
- Kim K, Kim WS, Jung CW, Im YH, Kang WK, Lee MH, Park CH, Ko YH, Ree HJ, Park K: Clinical features of peripheral T-cell lymphomas in 78 patients diagnosed according to the Revised European-American lymphoma (REAL) classification. Eur J Cancer. 2002, 38: 75-81.View ArticlePubMedGoogle Scholar
- Dearden CE, Johnson R, Pettengell R, Devereux S, Cwynarski K, Whittaker S, McMillan A: Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma). Br J Haematol. , 153: 451-485.Google Scholar
- Kim K, Chie EK, Kim CW, Kim IH, Park CI: Treatment outcome of angiocentric T-cell and NK/T-cell lymphoma, nasal type: radiotherapy versus chemoradiotherapy. Jpn J Clin Oncol. 2005, 35: 1-5. 10.1093/jjco/hyi006.View ArticlePubMedGoogle Scholar
- Kuo TT, Shih LY, Tsang NM: Nasal NK/T cell lymphoma in Taiwan: a clinicopathologic study of 22 cases, with analysis of histologic subtypes, Epstein-Barr virus LMP-1 gene association, and treatment modalities. Int J Surg Pathol. 2004, 12: 375-387. 10.1177/106689690401200410.View ArticlePubMedGoogle Scholar
- Huang MJ, Jiang Y, Liu WP, Li ZP, Li M, Zhou L, Xu Y, Yu CH, Li Q, Peng F: Early or up-front radiotherapy improved survival of localized extranodal NK/T-cell lymphoma, nasal-type in the upper aerodigestive tract. Int J Radiat Oncol Biol Phys. 2008, 70: 166-174. 10.1016/j.ijrobp.2007.05.073.View ArticlePubMedGoogle Scholar
- Li YX, Yao B, Jin J, Wang WH, Liu YP, Song YW, Wang SL, Liu XF, Zhou LQ, He XH: Radiotherapy as primary treatment for stage IE and IIE nasal natural killer/T-cell lymphoma. J Clin Oncol. 2006, 24: 181-189. 10.1200/JCO.2005.03.2573.View ArticlePubMedGoogle Scholar
- Yamaguchi M, Tobinai K, Oguchi M, Ishizuka N, Kobayashi Y, Isobe Y, Ishizawa K, Maseki N, Itoh K, Usui N: Phase I/II study of concurrent chemoradiotherapy for localized nasal natural killer/T-cell lymphoma: Japan Clinical Oncology Group Study JCOG0211. J Clin Oncol. 2009, 27: 5594-5600. 10.1200/JCO.2009.23.8295.View ArticlePubMedGoogle Scholar
- Obama K, Tara M, Niina K: L-asparaginase-Based induction therapy for advanced extranodal NK/T-cell lymphoma. Int J Hematol. 2003, 78: 248-250. 10.1007/BF02983802.View ArticlePubMedGoogle Scholar
- Yong W, Zheng W, Zhu J, Zhang Y, Wei Y, Wang X, Lin N, Xie Y, Xu B, Li J: Midline NK/T-cell lymphoma nasal-type: treatment outcome, the effect of L-asparaginase based regimen, and prognostic factors. Hematol Oncol. 2006, 24: 28-32. 10.1002/hon.765.View ArticlePubMedGoogle Scholar
- A predictive model for aggressive non-Hodgkin's lymphoma: The International Non-Hodgkin's Lymphoma Prognostic Factors Project. N Engl J Med. 1993, 329: 987-994.View ArticleGoogle Scholar
- Gallamini A, Stelitano C, Calvi R, Bellei M, Mattei D, Vitolo U, Morabito F, Martelli M, Brusamolino E, Iannitto E: Peripheral T-cell lymphoma unspecified (PTCL-U): a new prognostic model from a retrospective multicentric clinical study. Blood. 2004, 103: 2474-2479. 10.1182/blood-2003-09-3080.View ArticlePubMedGoogle Scholar
- Cheson BD: The International Harmonization Project for response criteria in lymphoma clinical trials. Hematol Oncol Clin North Am. 2007, 21: 841-854. 10.1016/j.hoc.2007.06.011.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
A great many of our clients at BPE Law Group are real estate investors who have long handled all of the tasks involved with owning and managing rental property. For those who are members of the Baby Boom generation and approaching retirement, the demands of management are in conflict with their desires to travel and possibly even move to a new location.
A professional property manager can possibly fill the gap… but it is not easy for hands-on owners to give up control especially if there is a concern about the manager's experience, diligence, and attention to property and tenant needs. For many of these owners, their rental income may be a substantial portion of their income. Will turning control over to someone else place them in financial jeopardy?
Here are some of the key factors to look at in choosing a property manager:
1. Licensed – In California, all property managers are required to be licensed by the Bureau of Real Estate. They must either hold a Broker's license or must be working under a licensed Broker.
2. Training – All real estate licensees are required to undergo training in real estate subjects – including property management – as a precondition for licensing. Advanced training and certification programs are available. Perhaps the best known designation is Certified Property Manager ("CPM") which is awarded to those who complete the rigorous experience and training requirements of the Institute of Real Estate Management ("IREM"). In addition, the California Association of Realtors has a Property Management Certification ("PMC") with 7 courses leading to the PMC designation.
3. Experience – The CPM designation requires that the candidate has at least 3 years of experience as a property manager in addition to the required training. No experience is required for the PMC designation. Under California law, there is no legal requirement that a property manager be either specifically trained or experienced.
4. Affiliations – Most property managers will be members of their local Board of Realtors and be a member of local and national property management organizations. Perhaps the best known of these is the National Association of Rental Property Managers ("NARPM") which has a very active Chapter in Sacramento. There are 136 Members in the Chapter including 26 companies that hold the designation of Certified Residential Management Company ("CRMC"). Here is a link to their website: SacNARPM.
Regardless of how you find a property manager, the individual and company must be prepared to demonstrate their training and experience in these key responsibilities:
1. Collect the rent timely
2. Take the calls from the tenant, be responsive, keep a record of calls
3. Arrange for repairs – do they have maintenance on staff refer to contractors
4. See that the repairs are done properly.
5. Send appropriate notices to the tenant for late or nonpayment of rent, violations of the rules, etc. Do or oversee evictions.
6. Get your approval for major expenses.
7. Inspect the property occasionally
8. Provide you with an accounting of all money received and disbursed monthly or quarterly, as well as keep a client trust account for owner money. State law regulates property managers much as it does real estate agents. And every state is different.
And whatever else you agree upon between you. In fact every responsibility of the property manager is agreed upon contractually.
A property manager is given substantial control over a valuable financial asset. Under California law, the manager owes you a "fiduciary duty" which is the highest duty of care. They must put your financial interests ahead of their own and the actions they undertake in your behalf must be in your best interests.
For over 20 years, the attorneys of BPE Law Group, P.C. have been advising and representing property owners, managers, and real estate professionals on all issues concerning the use of real property. If you would like a consultation with us, please call our office at (916) 966-2260 and our staff will schedule you with one of our very experienced real estate attorneys. Our flat fee consult for new clients may get you the answers you need for the questions you have. If you have a general legal questions, please e-mail me at firstname.lastname@example.com.
The information presented in this Article is not to be taken as legal advice. Every person's situation is different. If you are facing a legal issue of any kind, get competent legal advice in your State immediately so that you can determine your best options.

subset: commoncrawl


text:
* These rates are given as an indication they will be confirmed by telephone
with one of our advisers or by a quote that the technician will establish on site.
Check out all the reviews of ServiceLand customers who have applied for
Locksmith on pedroso
Thank you for your speed. And your professionalism. I will not hesitate; Remind you if I need to....
quick answer on the phone a little issue complicated of successful advices of the technician....
For your Locksmith in your city of pedroso


text:
by Pham Nhu Trang
My love like grass
Still grow up in you
Although on the rocky barren land
Or on desert, white sand
still green...
My love like grass
"My love like grass"
Labels: Pham Nhu Trang
2 comments:
- Jean Lewis said...
I like the way grass is used for a love which is always green and true. The fact that it falls on barren ground is a sad reflection of what is all too often true. I think this poem
shows great promise.
- June 25, 2012 at 3:16 AM
Việt Nam thật đẹp ly le
- February 14, 2013 at 4:00 AM


text:
Your Irish Granny's Soda Bread
March 16, 2012
This Irish Soda Bread recipe comes to me from friend Molly Sinnett, who answered my Facebook plea for an authentic loaf. Something passed down from an Irish Granny would have been ideal, and she totally delivered!
This is a complete departure from the soda bread I picked up last weekend in Carroll Gardens (Caputo's Bake Shop, those are most definitely eggs in your dough…I'll be back for your hot cross buns though!).
I was wary of using margarine in the recipe, with its hydrogenated oil; but, I didn't exactly want to substitute butter when her recipe specifically says "don't use butter!" So, I went with a stick of Smart Balance and crossed my fingers.
The secret to this loaf has to be the soured buttermilk–the crumb is perfectly tender and reminds me of a colossal scone. And I absolutely love scones. So very excited for a thick slice for breakfast tomorrow with my Irish Breakfast tea. Happy St. Pat's everyone!
Granny's Irish Soda Bread
(Thanks Molly!)
- 5 cups unbleached all-purpose flour
- 1 rounded tsp baking soda
- 1 rounded tsp baking powder
- 1 cup sugar
- 1 stick margarine, sliced into 8 Tbsps (I used Smart Balance)
- 6-8 ounces raisins (or more if you desire)
- 1 1/2 cups sour buttermilk (to sour add 1 tsp white vinegar and let sit at room temp 1/2 hour)
- Mix together first 4 ingredients. Using a pastry cutter, blend the margarine into the flour and sugar mix. Add raisins.
- Create a well, pour in the buttermilk and stir. Use hands to fully incorporate wet and dry ingredients.
- Divide dough into 2 round loaves. Set in center of cake pans that have been greased and floured. Cut an X into the top of each loaf and bake at 375 degrees for 45-50 minutes.


text:
Francis Darrell Sprinkle, 77
Francis Darrell Sprinkle, 77, of La Monte, MO, passed away Sunday, June 22, 2014 at his home, He was born on January 8, 1937, a son of Francis and Mable (Finley) Sprinkle.
On April 7, 1959 at Bridal Cave in Camdenton, MO, he was united in marriage to Darlene Kay Atkin, who survives of the home.
Francis owned and operated Sprinkle's Welding and Repair Shop in La Monte for many years.
Besides his wife, he is survived by one son, Tony Sprinkle of Columbia; two daughters, Chris Jamison (Phil) of Macks Creek, MO; and Joyce Bruecher (Paul) of Sedalia; three sisters, Alleen Glidewell of Mobile, AL, Pauline Fisher of Raytown, MO, and Carolyn McMahon (Joe) of Olathe, KS; and five grandchildren, Anthony Jamison, Kenny Jamison, Cora Sprinkle, Calvin Bruecher, and Justin Bruecher.
He was preceded in death by his parents and one sister, Betty Eckhoff.
A visitation will be held from 2:00 p.m. - 5:00 p.m. on Sunday, June 29, 2014 at La Monte Baptist Church.
Memorial contributions are suggested to Bothwell Hospice in care of the family.
Arrangements under the direction of Rea Funeral Chapel, Sedalia, MO.
Online condolences may be conveyed to the family at www.reafuneralservice.com


text:
Xion Audio Player is an ultra light and easily skinnable Audio Player. Xion Audio Player also supports direct loading from Zip files which allow you to package several .PSD files in the one package. This has the added benefit of being compressed and therefore consumes less disk space.
Xion Audio Player supports not only skins but also various plugins. Currently it has more than 600 skins and 2 plugins in its directory. It has a very unique interface. It can also be used in minimized version just like Winamp.
- Ultra easy to skin using a powerful skinning system
- Complete animation support
- Skins load directly from .PSD files, not script or extra files required!
- Powerful playlist support
- Seamless playback
- 10 band equalizer with presets
- Blazingly fast, low cpu and low memory consumption
- MP3/OGG (Shoutcast, etc) internet radio streaming
- Customizable global hotkeys
- Auto play and position saver
- Single click play/pause
- Volume and balance controls
- Full system tray functionality
- MSN Messenger and Windows Live Messenger Integration
- Future Expansion through Components
Zion Audio Player support almost all audio format. You can check the complete list here. A portable version of this audio player is also available which can be used directly from your portable USB drives. It works in Windows XP, Vista as well as in Windows 7. If you are looking for a cool, new audio player, just try this one.
[ Download Xion Music Player ]


text:
Pack Some Action and Knock'em Out!
A Mobile Boxing Experience on a Whole New Level.
Honor, power and wealth they say you can't have it all. But hey kid, they're all lying. Enter the world of Boxing, and you can seize it all. Rise from the dirty streets and reach the exalted World Championships. Arm yourself with custom gloves, hone your killer moves and Knock'em Out with a Mega Punch! Win glorious trophies and even more glorious cash. Majestic mansions and slick rides will make your friends jealous, in addition to giving you powerful bonuses! Believe me, all this greatness is just within your grasp.
Now kid, show the World who the real Boxing Star is.
▶ Dodge your opponent's attacks, and throw the perfect counter!
▶ Watch your fighter evolve from an amateur to a Boxing Star in Story Mode!
▶ Meet countless colorful characters!
▶ Find the best combination of various skills and items fitting your fighting style!
▶ Collect and equip powerful gloves that unlock vicious Mega punches!
▶ Spend like a winner with the spoils and show off your riches on social media!


text:
Weather: Sunny Today.
GRASS is the word for today, gotta get the yard at home done today. Sunny outside so it should be a good day to work in the yard.
Weather: Sunny Today.
GRASS is the word for today, gotta get the yard at home done today. Sunny outside so it should be a good day to work in the yard.
Weather: 50 and cloudy.
I had a good day yesterday, turns out my air cleaner was clogged on the lawn mower I think and it just flooded out the motor. Guess a little preventive maintenance would have avoided the problem. Good news is I had one on the shelf, just too lazy to put it on I guess. It was too wet to finish cutting grass so I just got a cooler of beer and sat in the garage down by the Lake at Mom's house. Nothing better than sitting in a garage on a rainy day drinking beer. But I think I am going to need a screen to put in the garage door opening, Holy Mosquitos, I feed them pretty good yesterday.
Weather: Rainy.
Partly shitty and some rain too. But you know what they say, " A shitty day in the UP is better than a sunny day any place else". I gotta go check on the lawn mower today, it quit on me yesterday and being pissed I just walked away from it. Now it's time to go check it out.
Not much going on up here, maybe I can try this for excitement.
Weather: 80's and sunny.
Now we are talking, beautiful today. What a great day to work on my honey do lists. Or maybe I'll just cut grass. Lots of grass to cut.
An English tourist was driving through the South Island of New Zealand when he noticed a man on the side of the road having sex with a sheep.
A few kilometers further on he came upon a small town, so he parked his car and went into the pub for a drink.
He grabbed a cold beer, sat at a table, and then took a look around the bar. He immediately noticed a one-legged guy sitting over at a corner table, masturbating without a care in the world.
The English tourist turned to the bartender and said, "What sort of country is this? A few kilometers back down the road there was this guy having sex with a sheep and now that guy in the corner is masturbating in full view of everyone."
The bartender said, "You heartless bastard. He's only got one leg. How do you expect him to catch a sheep?"
Weather: 70's and rain,getting warmer.
Rain again, go figure. Who cares, I have to work anyway. Lots to do around here, Mom's house is going to end up just being a bunch more items on the Honey Do list, that probably won't get done. This is going to be a hard one to juggle, Mom's list, Becker's list.
I have a correction from yesterday on the size of Geko's walleye, Ernie said it was 28-30″, turns out it was only 25″, imagine that, a guy over estimating lengh by 3-5″.
Did you ever wonder why there are less white guys in the NBA?
Weather: 60's and rain again.
Warm and rainy for a few days. That's good, we have to water them mosquitos. It was a good weekend in the UP, Had Mom and brother Pat up, finished all the house closing stuff for Mom and she gave me a ToDo list of stuff to get done before she moves up for good.
Fishing has been getting a little better from what I have been hearing, Geko pulled this one in with Ernie manning the net. Ernie claims it is 28-30″ but didn't have a tape with him. Damn I wonder what they do with them 14 & 1/2 inchers?
Weather: 60's and rain.
Kind of crappy out side but what are you going to do, sit inside and drink beer maybe. But when drinking a beer today please remember why Memorial Day was started, to Honor those that lost their lives for our country while serving in our Armed Forces.
Weather: Overcast and warm.
Well looks like I missed a day. Sorry but Mom was here and I was a bit pre-occupied. The pic below is Mom in her front yard, about 4 more weeks and she will be waking up here every morning. We had a very relaxing weekend, went from not being able to close on Friday because of paperwork issues to issues being solved, closing taking place, then drinking beers on the deck with mom. Life does not get any better.
Weather: Beautiful, just fricken Beautiful.
Well as luck would have it, (or maybe no luck) a snafu in the paperwork is not allowing us to close on Mom's house today. Total bummer, and no free beer at the party today. I repeat there is no party at Mom's today. Everything will work out though, the paperwork should go through next week, Mom was headed back to Indiana on Sunday to finish packing anyway. Looks like we will have to change it to a U-Haul unloading party on June 20th instead.
A lawyer boarded an airplane in New Orleans with a box of frozen crabs and asked a blonde flight attendant to take care of them for him.
She took the box and promised to put it in the crew's refrigerator. He advised her that he was holding her personally responsible for them staying frozen, mentioning in an arrogant manner that he was a lawyer, and threatened what would happen to her if she let them thaw out.
Shortly before landing in New York , she used the intercom to announce to the entire cabin, "Would the lawyer who gave me the crabs in New Orleans please raise your hand to identify yourself?"
Not one hand went up … so she took them home and had fresh-cooked crabs for dinner.
There are two lessons here:
1. Lawyers aren't as smart as they think they are.
2. Blondes aren't as dumb as many folks think they are.
Weather: Beautiful, at least for the next few days.
Sweet, sunny outside and my Mom is on her way up to close on the house tomorrow. I am busy doing the important things like getting beer on ice and filling the boat with gas. We will be having a little open house Friday night if you are in the area just take a right on the end of Goose Lane, Party should start around 6ish.


text:
It is appropriate, perhaps, for the grandson of the inventor of the snowmobile to turn his hand to designing an aircraft specifically for operations in the Arctic. That person is Canadian industrial designer Charles Bombardier, and his design is a ground-effect cargo aircraft called the Nunavik Arctic Express.
Inspired by Russia's wing-in-ground-effect Ekranoplan - and watching episodes of Ice Road Truckers, it seems - the Nunavik is designed to fly at up to 200mph, 15-50ft above the sea, ice and tundra as it moves cargo between Arctic locations in support of drilling and mining operations, as well as border patrol and search-and-rescue missions.
The concept is powered by four 1,500shp Pratt & Whitney Canada PW100 turboprops and has a boxy cargo-friendly fuselage similar to the Shorts 360 -- inspired by is hardly the right phrase -- carrying up to 36 LD2 containers accessible by forklift via large side doors. The airframe would be composite for lightness and ruggedness, Bombardier says.
He acknowledges some challenges with the design, including maneuvering at such low altitude in airspace beyond radar coverage. He suggests fitting an autopilot using radar and laser altimeters and flying corridors determined by the regulatory authorities. Taxiing also needs to be tackled (the concept has skis) and Bombardier is looking at a water takeoff capability.
Bombardier the grandson is an industrial designer, not an aircraft (or snowmobile) engineer, and seems pretty open to constructive comments on his concepts, only a few of which are aircraft - like the Antares STOL airliner we featured recently on Things With Wings. So be sure to visit his website and let him know what you think.
- Graham Warwick's blog
- Log In or Register to post comments
- Manchester's New Long-haul Routes
- Supersized Prang


text:
By getting most of these into account, you should have no problem selecting the proper products.
With just about no Body fat, carbs, or cholesterol – and ZERO included creamers or gums that other goods tend to use as fillers and thickeners – you're acquiring on the list of purest top quality isolated products and solutions out there. Bear in mind, the best enter = the ideal output.
Even though you may get your protein from food stuff resources - and It can be recommended that you just do - protein powder is a wonderful addition to make sure you get adequate regularly.
Since our Site is synchronized Along with the USPTO data, we advise earning any knowledge variations with the USPTO straight. Our Web-site will auto-update once the USPTO details is updated.
Casein protein powder is really a bit by bit digesting protein which could aid offer a constant stream of amino acids towards the muscles for lengthier durations.* Casein is perfect to choose suitable ahead of mattress, for all night recovery.*
- If you are new to LegalForce/Trademarkia, be sure to just enter your Speak to e mail and create a password being related to your critique. If you already have a LegalForce/Trademarkia account, remember to enter your account's electronic mail and password in advance of publishing your critique. * Please Fee: * Your Review:
Need a protein complement low in lactose? Check out the big choice of reduced-lactose protein products! Categories Index
– 28% BCAAs. Our formula is fortified with about 7g of BCAAs for each 25g protein serving – one of the best concentrations readily her response available
The USPTO tends to make this knowledge available for research by the general public in order that people today can Find ownership details for mental property, Significantly exactly the same way a county might make real estate property property ownership data offered.
Obtaining the appropriate protein is vital, and There are a variety of differing kinds that you're going to will need to pick from to perform your objectives.
Should web link you abide by this easy guideline, your muscles should have almost everything they should recovery out of published here your workouts and you'll get the results you're looking for!
– Among A very powerful amino acids to strengthen athletes and bodybuilders. It plays an important job in gut wellbeing, intestinal wellness, muscle metabolism, and mobile support
No statements on this page happen to be accepted with the FDA. Get hold of a doctor and obtain penned authorization
Your muscles will likely be a lot less sore immediately after your exercise routines due to amplified Restoration level, in addition to the fact that your exercise sessions by themselves will likely be a lot more successful because of the elevated levels of power and endurance the BCAAs allows for.
Everything about Rule 1 protein
By getting most of these into account, you should have no problem selecting the proper products.


text:
The Cebu Medical doctors' University (previously Cebu Health professionals' College or university) was granted College standing on November 2004. It is the only faculty while in the Philippines designated a university without the need of aquiring a fundamental schooling (pre-university ??high school) curriculum; it caters mostly to classes associated with the health providers subject.
For anyone who is booking journey for children who will be travelling alone, remember to Look at the age constraints set by the working provider prior to reserving.
An Grownup travelling with youngsters needs to be more than eighteen many years of age. For ticket bookings of a lot more than 9 passengers, be sure to Get in touch with your neighborhood reservations Business office
Since the nationalists misplaced the Chinese civil war, the artifacts in no way discovered their way back to Beijing.
Circa 1900 can be a colonial dwelling that has been restored right into a cafe, piano bar, and performance location.
Telecommunication facilities, broadband and wi-fi Online connections are offered and therefore are supplied by many of the nation's biggest telecommunication organizations.
Welcome to Rappler, a social news community wherever stories encourage community engagement and digitally fuelled actions for social improve. Rappler arises from the root words "rap" (to debate) + "ripple" (to help make waves).
hi there there! It really is my very first time to go to the area and i am grateful & fulfilled due to the fact I used to be givin an opportunity to see and is familiar with the heritage with regards to the island... its a remarkably encouraged museum and its pretty very affordable!
Street reveals and shows are also held right here so don?�t be surprised when customers group in specified locations.
Become a Element of our loyalty programme and revel in An array of privileges and Advantages to our most Recurrent flyers. See complete account Gains.
Scheduling of greater than 8 rooms is currently not obtainable on line. Make sure you Get hold of your local reservations Business office. Full no. of Adults
This is often 2nd time to use this hotel and we really liked. A lot of things were being at no cost, staffs had been Tremendous pleasant and sort, very accecible For lots of sights. I will definitely use this hotel on up coming excursion in Taipei.??We believe that evaluate contributions and property responses will spotlight a wide array of views and ordeals, which happens to be critical in assisting friends make knowledgeable selections about wherever to stay.|Tooltip about travelling with little ones. Press enter to increase. A kid visitor is classed as becoming 17 several years outdated or under. All youngsters must be accompanied by an adult guest. A optimum of four adults and three kids may perhaps stay in one particular room.|I went with someone that is extremely instructive and proficient about Filipino history, so my practical experience was really enlightening.|[fifty][fifty one] Many international and cargo airlines fly to Cebu. There's also direct transfer flights through the money's Ninoy Aquino Global Airport that commonly hook up the town to other Locations check here on earth.|Peaceful resort with comfy bed, totally free refill of mineral water and snacks daily, will definitely remain right here once more.|Pizza and rooster are amazing. Number of pizza flavors. Pasta was a little 'meh' ,but i'm like that with pasta. Would i eat here all over again? Each individual weekend if possible. What a lot of people usually not point out is the fact It truly is just p200. Significantly, you felt like you wasted your p200? U nuts?|Booking of more than 6 travellers is at this time not readily available on the web. Remember to Make contact with your local reservations office.|An Grownup travelling with small children need to be in excess of 18 here a long time of age. For ticket bookings of greater than 9 travellers, you should Make contact website with your local reservations office|Most effective fares on flights observed by Other folks in the last 48 several hours. (Make sure you Observe that some fares may well only implement when there are 菲律賓遊學代辦 actually various travellers.)|Intending to this museum is a great way for to start with time holidaymakers 菲律賓遊學 to understand Taiwanese culture and history. The doorway rate is NTD160 for Older people and NTD eighty for college students with IDs. The museum is found in Taipei?�s Shilin district.|By 1569 the Spanish settlement in Cebu had turn out to be crucial as a safe port for ships from Mexico and as a leaping-off place for even further exploration on the archipelago. Little expeditions led by Juan de Salcedo went to Mindoro and Luzon, where he and Martín de Goiti performed a leading role from the subjugation on the Kingdoms of Tundun and Seludong in 1570.|Every boy or girl passenger need to be accompanied by an adult. For more information on bookings with little ones, remember to contact your neighborhood reservations Place of work or see our rules for kids travelling.|[66] It can be at present headed by the Augustinian Recollects and has two various campuses throughout the metropolis, excluding a new campus exterior the city situated in the municipality of Balamban.}
Tooltip about travelling as an adult. Push enter to broaden. An Grownup travelling with kids must be in excess of 18 yrs of age. For ticket bookings of over 6 passengers, please Speak to your local reservations Office environment}
Not known Factual Statements About cebu
The Cebu Medical doctors' University (previously Cebu Health professionals' College or university) was granted College standing on November 2004. It is the only faculty while in the Philippines designated a university without the need of aquiring a fundamental schooling (pre-university ??high school) curriculum; it caters mostly to classes associated with the health providers subject.


text:
The Georgia College women's basketball team (18-10) will play Columbus State University (20-7) in the Peach Belt Conference (PBC) Tournament Championship Sunday, March 9, in Columbus, Ga. The West Division No. 4-seed Bobcats will take on the West Division's No. 3-seed Cougars, who advanced after beating East Division No. 2-seed Flagler Thursday and West Division No. 1-seed and PBC Regular-Season Champion Clayton State University in the semifinals. The Bobcats return to the finals for the first time since 2011, when they defeated USC Aiken for GC Women's Basketball's seventh PBC Tournament Title. Bobcats head coach Maurice Smith is 5-0 in PBC tournament games. Catch the action on the HomeTeam Country102FM and ESPN 1450AM; GC Hall of Famer Scott MacLeod and sports information director Al Weston will bring you the call. The Bobcats are 4-0 in neutral site games this season.
The all-time series has the Bobcats and Cougars tied with 24 wins apiece. The teams met twice this season with Columbus State taking both contests. The Cougars won in Columbus, Ga. 79-55 Feb. 1 by 24 points, and again in Milledgeville, Ga. two weeks later 65-54 by 11 points. The 54- and 55-point totals would be the third and fourth fewest scored for the Bobcats this season, respectively. The Bobcats and Cougars met last in the PBC Tournament in 2011. Georgia College beat Columbus State 63-45 in the quarterfinals that year on their way to the title. In that game, the Bobcats were the West's second seed, while the Cougars were the West's third seed.
The Georgia College women's basketball team (18-10) got three 21-point performers to help push past No. 23 University of North Georgia (22-6) 83-67 Saturday in the semifinals of the 2014 Peach Belt Conference (PBC) Tournament.
Senior Brandi McKinney, and All-PBC Second Team juniors Enisha Donley and Shanteona Keys each netted the 21 points to get 63 of the team's 83.
The Bobcats never trailed in the contest, starting off on a 9-0 run. The lead reached as high as 20 twice in the first half. The first 20-point lead came with 12:45 left in the first frame, leading 24-4 after a three from McKinney.
It was more of the same in the second half, as UNG failed to get the deficit any closer than 11 over the remaining 20 minutes.
McKinney had 13 of her 21 in the second half, finishing 4-for-7 from long range. She added a team-best nine rebounds, and five big steals. Donley was 9-of-15 from the floor with eight boards. Freshman guard LaRice Walker scored 13 points, getting 7-for-9 from the free-throw line.
The Georgia College women's basketball team rallied from a 13-point deficit before falling to Columbus State University, 65-54 Feb. 15 at the Centennial Center. Junior Shanteona Keys led the team with a double-double netting 17 points, 11 boards, and three assists; while freshman LaRice Walker added 14 points, and three assists and steals.
The Cougars went on an early 13-point run that allowed them to take a nine-point lead into the intermission at 32-23.
Columbus State went up 13-points early in the second half before the Bobcats came to life. Georgia College went on an 18-3-run to take the lead at 43-41. Nine of the 18 points came off threes with McKinney, Walker, and Keys hitting from downtown. Keys' three gave the Bobcats their first lead at 43-41 since the opening minutes of play. The Cougars would finish the game with a 14-3-run with eight of those points coming from Tae Smith to seal the win.
The Bobcats have four different players that are listed in nine top-10 PBC categories that include points-per-game, points, field goals, field-goal percentage, 3-pointers, 3-point percentage, free-throw percentage, steals and blocks. The Bobcats also placed two players on the All-PBC teams.
Enisha Donley has been named to the 2013-14 All-PBC Second Team and is ranked in four top-10 PBC categories while leading the Bobcats in scoring. Donley is fifth in PBC points-per-game (16.8), fifth in PBC points (454), fifth in PBC field goals (187) and fourth in PBC field-goal percentage (.539).
Shanteona Keys also has been named to the 2013-14 All-PBC Second Team. This is her second-consecutive selection to the second team while making the third team as PBC Freshman of the Year two seasons ago. She is also a two-time Academic All-American. Keys is seventh in PBC points-per-game (15.6), sixth in PBC points (436) and seventh in PBC field goals (161).
Brandi McKinney is the Bobcats' best player from the bench as she ranks in four PBC top-10 categories. McKinney is third in PBC 3-pointers (58), fourth in PBC 3-pointer percent (.372), eighth in PBC free-throw percentage (.794) and fifth in PBC steals (64).
Abby Slocumb is fourth in PBC blocks with 47. She will end her career No. 2 on the Georgia College all-time blocks list currently having 112, and her 47 this season is the fourth-highest total in a season in a Bobcat uniform. The third-highest single season total for blocks in a season is 67 (2009-10) held by the all-time shot blocker at Georgia College, Antoinette Reames (2008-10) with 140.
Shanteona Keys is currently ranked in four top-10 Georgia College all-time categories that include points, field goals, free throws and 3-pointers. She picked up her 1,305th point in the win against UNG Saturday, March 8. Keys needs 43 more points to tie current No. 3 Betsy Foy's (1999-02) 1,348 points. Keys' 138 threes currently rank her at No. 8 on the Georgia College all-time threes list and she is 10 threes away from tying current No. 7 Brett Haggard (1997-01). Keys is No. 5 in Georgia College all-time field-goals with 451 and needs 46 more to tie current No. 4 May Neloms (1984-88). Keys ranks No. 4 in Georgia College all-time free throws at 265 and needs 19 to tie current No. 3 Sherita Ballard (1987-91) at 284.


text:
Banning unhealthy food advertising to children
February 9, 2017SPHERU's Dr. Rachel Engler-Stringer joined the Heart and Stroke Foundation last week in talking about how the food and beverage industry are marketing unhealthy options to children in Canada.
On Feb. 1, the Heart and Stroke Foundation released their annual report entitled, "The kids are not alright. How the food and beverage industry is marketing our children and youth to death."
Dr. Engler-Stringer and Fleur Macqueen Smith, director of government relations and health promotion of the Saskatchewan Heart and Stroke Foundation, appeared on Global News Regina and Global News Saskatoon to explain the effects food and beverage advertising have on children and their families.
During her appearance on the Global Regina News Morning Show, Dr. Engler-Stringer explained that since 1979, obesity rates in children have tripled in Canada.
"What the Heart and Stroke Foundation is calling for, and I agree with, is a ban on advertising of food and beverages to children under the age of 16," Dr. Engler-Stringer said.
According to the report, research shows that 90 per cent of all food and beverage advertising to children is promoting unhealthy food, high in salt, sugar and fat.
The Heart and Stroke Foundation also commissioned a poll to determine how Canadians felt about advertising to children. Many parents felt as though the odds were stacked against them when it came to advertising, Dr. Engler-Stringer said.
A prime example of limiting food advertising to children is what's currently happening in Quebec. In 1980, Quebec implemented a complete ban on advertising to children under the age of 13. As a result, Quebec children, particularly francophone children, have lower rates of fast food consumption as well as one of the lowest obesity rates in Canada.
For more information, check out Dr. Engler-Stringer and Fleur Macqueen Smith's interviews on Global News Morning Regina, Global News Morning Saskatoon and Global Saskatoon Evening News.


text:
This story was delivered to BI Intelligence " E-Commerce Briefing" subscribers. To learn more and subscribe, please click here.
The United States Postal Service (USPS) is testing new in-store kiosks that help eBay sellers send out their packages more quickly, reports eCommerce Bytes.
The kiosks are placed within US Post Office locations where eBay sellers can scan their packages for initial intake with the USPS without having to wait in line. eBay sellers are choosing to go to the post office despite being able to print out postage labels from their home or office to drop them in the mail.
The new kiosks will help these sellers save time and could help them ship out a higher volume due to its convenience. It can also help eBay sellers appease customers that insist on speedy send-outs accompanied by a notification to their email or mobile phone.
The USPS is likely trying to present e-commerce merchants with easier shipping solutions after implementing a rate hike this past January. Prices across Priority Mail, Parcel Select Lightweight, and First Class Package International Service packages all increased, directly impacting online sellers.
This price hike could have already encouraged some e-tailers to find other shipping options, like UPS, FedEx, and even Uber. Moving forward, we expect to see more initiatives from the USPS that remove friction for online merchants, like long wait times and high shipment volume.
The parcel delivery industry — a segment of the shipping sector that deals with the transportation of packages to consumers — is booming thanks to e-commerce growth, and players outside the industry want a piece of the pie.
Evan Bakker, research analyst for BI Intelligence, Business Insider's premium research service, has compiled a detailed report on the future of shipping that looks at efforts by Amazon, Alibaba, and Walmart to handle more of their own shipping and concludes that big retailers are well positioned to disrupt the parcel industry.
Here are some of the key points from the report:
- Transportation and logistics could be the next billion dollar opportunity for e-commerce companies. The global shipping market, including ocean, air, and truck freight, is a $2.1 trillion market, according to World Bank, Boeing, and Golden Valley Co.
- There is much at stake for legacy shipping companies, which have seen a boom in parcel delivery as e-commerce spending has risen. Twenty different partners currently share the duties of shipping Amazon's 600 million packages a year, with FedEx, USPS, and UPS moving the most.
- Amazon, Alibaba, and Walmart have so far focused on building out their last-mile delivery and logistics services but are increasingly going after the middle- and first-mile of the shipping chain.
- Amazon has already made major moves across each stage of the shipping journey. It launched same-day delivery service, which it handles through its own fleet of carriers, cutting out any third-party shippers. The company also recently began establishing shipping routes between China and North America.
- Walmart's interest in expanding its transportation and logistics operations is almost purely related to cost-savings. It's begun leasing shipping containers to transport manufactured goods from China and is making greater use of lockers and in-store pickup options to cut down on delivery costs.
- Alibaba has begun leasing containers on ships, similar to Amazon's Dragon Boat initiative. This means that Alibaba Logistics can now facilitate first-mile shipping for third-party merchants on its marketplace.
In full, the report:
- Sizes the market for the shipping industry.
- Explains how the industry operates in broad terms.
- Suggests why major e-commerce retailers should disrupt the space.
- Outlines the shipping initiatives of Amazon, Walmart, and Alibaba.
- Concludes how these moves might impact traditional carriers.
Interested in getting the full report? Here are two ways to access it:
- Subscribe to an All-Access pass to BI Intelligence and gain immediate access to this report and over 100 other expertly researched reports. As an added bonus, you'll also gain access to all future reports and daily newsletters to ensure you stay ahead of the curve and benefit personally and professionally. » START A MEMBERSHIP
- Purchase & download the full report from our research store. » BUY THE REPORT
The choice is yours. But however you decide to acquire this report, you've given yourself a powerful advantage in your understanding of the future of shipping.


text:
Another band from Bordeaux (from where are also coming Oyabun, Sun Preachers and Marble Chariot) is BAGARRE GENERALE... Meaning "General Fight" in french, I guess such a name would rather more suggest some HC sound behind it, something at least more noisy and revolting.
But don't misunderstand me, the band's sound is everything except something pacifying, it's damn dark, heavy and crushing !
In fact this instrumental quatuor consisting in Alix (BassTrombone) ,Gabriel (Guitar), Olivier (Bass & Keyboards) and Cyrille (Drums & Trombone), describe their style as retro-futurist Metal but their label does it more concretely through a description that is amazing and absolutely fair about the various emotions brought by the unique moods of their long epic songs, full of massive and haunting guitars with this trombone enhancing every sensations, could they be disturbing, cold, bleak and blazing :
"Bagarre Générale c'est un peu comme courir nu dans la forêt en tirant en l'air avec un fusil d'assaut et deux ou trois acides qui fondent sous la langue.
Comme si Keelhaul et High On Fire , pris d'une crise de Zeuhl, sortaient les cuivres comme on brandit une machette.
Ou encore comme si les fantômes lubriques de Malher et Moussorgski se mettaient à sodomiser tout azimut les jeunes éphèbes du math-metal.
Bagarre Générale c'est une musique épique, massive et irréelle où les cuivres se mélangent aux guitares pour dérouler des beignes soniques et accoucher d'un magma de terreur soutenu par une section rythmique implacable et insatiable."
in English this could more or less give :
"Bagarre Générale" sounds a bit like running naked in the forest shooting into the air with an assault rifle and two or three acids dissolving under the tongue.
As if Keelhaul and High On Fire, caught by a Zeuhl's cris, took out the brass as brandishing a machete.
Or as if the lustful ghosts of Mahler and Mussorgsky began to sodomize young men bearing all the math-metal.
Bagarre Générale plays a music that is epic, massive and unreal where brass are mixed with guitars to sonically smash your head and deliver a magma of terror backed by a relentless and unstoppable rhythmic section."
I'd like to thank Chris from Huata to have mentioned this killer band in his end of year-list (to be published in about 10 days), that's the main goal of this topic where everyone mentions his faves of the years, including some cool revelations... like Bagarre Generale (for him and maybe you too now), help curious people to always find new gems displaying heavy sounds !
I suppose this must be called an EP, considering it contains 4 songs for about 30 minutes but who cares after all, if you do your market on bandcamp then this is a name your price affair that deserves a few bux more than many full length albums ; and in any case a vynil edition is available here !!!
Facebook page


text:
Google Think Voices captures a four part interview with Avinash Kaushik on how to succeed in the digital world using key insights to evaluate and refine the customer experience.
Avinash reveals tips on how to elevate your marketing efforts to capture maximum consumer favorability.
The first video segment details three important tracking metrics to implement for a full view of your marketing effectiveness. The metrics he highlights are:
- Task Completion Rate
Involves leveraging surveys and qualitative data to understand the customer experience with your brand. This data assists retailers in making adjustments efficiently at scale to increase consumer satisfaction and conversions.
- Economic Value Added
An analysis of the macro and micro conversions leading to a positive contribution to a business' bottom line. Move beyond measuring clicks and impressions to derive additional insights of the true value of acquired customers.
- Bounce Rate
A measure of consumer activities tied to the effectiveness of your campaigns and landing pages. By examining the number of people that visit a site and leave immediately, retailers are able to focus on areas within the shopping cycle that could be improved.
The second video focuses on finding insights to make smart marketing decisions that result in a higher conversion rate. Avinash discusses how DoubleClick Ad Planner can help precisely target consumers that are hard to reach by linking demographic data to search behavior.
Here are few more videos that may be of your interest:
In this video, Kaushik talks about changes in how people are influenced. Marketers have grown accustomed to shout channels, but increasingly people are influenced by marketers participating in conversations on sites like Facebook and Twitter.
Here Kaushik talks about the importance of experimentation with websites. He suggests bringing everyone together with ideas, and then implementing different versions of a website and testing their success through tools like Google Website Optimizer, Adobe Test & Target, and Optimost.
Kaushik gives an example of a company, E.L.F., using conversation and social media channels to fuel growth. E.L.F. does not use shout channels, but instead finds key influencers through social media sites and empowers them to have conversations about the company's products.
He talks about the disappearance of an online / offline world, and the emergence of a 'nonline' world. People move between the two realms with no friction, and marketers need to do a better job of integrating the two in campaigns.
In this video, he goes over some of the most important data for evaluating online websites. Kaushik talks about the importance of bounce rate – the number of people that refuse to give your site a single click – and of loyalty and recency measures.
[Via: Google Retail Advertising Blog]


text:
I have setup and Elastic load balancer in VPC. There is a public and private subnet. Currently the web server is in the Private subnet and there is a NAT instance in public subnet, from which the web server can be accessed.
Now when i created an Elastic Load balancer, which pointed to the web server in private subnet, the requests from ELB are not being sent to web server.
Is there any special method through which i have to configure ELB in VPC?


text:
Hey everybody, we're back from a long break with a brand new Game Breakers Podcast featuring the usual cast as well as our great guests: David Hellman and Tevis Thompson, the creators of Second Quest. We have a great time talking about Zelda and their book, so come and have a listen!
Oh, and by the way, we have an RSS feed now! Come subscribe to keep updated!
David Hellman: https://twitter.com/davidhellman
Tevis Thompson: https://twitter.com/tevisthompson
Zack O'Neill: https://twitter.com/ChimeraReviewer
David Jones: https://twitter.com/DJs_SecretPlans
Podcast: Play in new window | Download


text:
Parsons X Styletag Weekender Challenge Winners Announced
Parsons and StyleTag have announced the winners of the Station-to-Station Weekender challenge, which awarded our designers over $25,000 in prizes. After months of trend-sighting on StyleTag's app, our designers have generated a huge social network of images of the fashion on New York's streets.
Between February 6 and March 10, 2014, students from across our three campuses (New York, Paris and Parsons AAS Online) were asked to create and upload original photos to Styletag, a fashion-sharing app used by designers, photographers, bloggers, stylists and others in the fashion industry. Through the app, Styletag gave Parsons' designers exposure to the global fashion community. In this image-making, trend-based competition, sponsored by Styletag, participants uploaded their posts to Styletag once per day for the duration of the challenge. Entries of original photographic content focusing on today's trends and consumer insight were eligible for cash prizes.
Simon Collins said, "As fashion and technology have grown increasingly intertwined, Parsons is very pleased to have partnered with the innovative Styletag app. With an interface that celebrates real-world designs and trends while harnessing the power of technology, it is an indispensible tool for fashion education in our digital age."
Russ Eisenman, head of marketing for Styletag's developer, San Francisco-based SK Planet, Inc., adds, "Giving young talent a place to shine is why we built Styletag, and we're thrilled so many Parsons students have joined. The Parsons Challenge has allowed us to showcase the versatility of the Styletag platform as much more than a handy app for mobile commerce – it's a forum for the digital fashion community to share ideas and images, spot trends, get inspired and even get discovered."
Weekender Challenge entries were judged based on the following criteria: ability to capture trends and consumer insight; image quality (artistry, color, lighting, styling, composition, etc.); inclusion of descriptive trend information; and inclusion of sufficient and accurate product information, with bonus points awarded for live purchase links.
Styletag awarded cash prizes in three categories: Women's Ready-to-Wear, Accessories and Trends.
Winners in each of these categories are:
1. Malaika Haaning
2. Olivia Burca
3. Jennefer Keyserman
1. Diotime Boudoussier
2. Vicky Bateman
3. Kylie Conibear
1. Jill Lao
2. W. Griffin Snyder
3. Katrina Chan
Featured Styletag work was on display alongside thesis work from students in the AAS Fashion Design and AAS Fashion Marketing Programs at an end of the year exhibition taking place between May 22-30.
This post originally appeared on the 560 Parsons School of Fashion magazine.


text:
Reverend Dennis W. Broughton, Jr. is a dedicated, third generation member of the AME Church whose ministry as preacher, teacher, theologian, and scholar of the gospel of Jesus Christ has spanned fourteen years. Pastor Broughton currently serves as pastor of Wayman Chapel African Methodist Episcopal Church in Sumter, South Carolina.
At Wayman Chapel, Pastor Broughton is deeply engaged in what he describes as a "Communal Ministry" in which pastor and people work collaboratively to lift up our Lord and Savior Jesus Christ. Believing that every person has something special to offer, his goal is to provide guidance, inspiration, love, and support to his church family and others throughout the Sumter community. Pastor Broughton achieves this goal by employing the power of prayer, the Word of God and the Holy Spirit to inspire himself and others to overcome despite the many barriers and obstacles in our troubled world and become more faithful servants of God and more obedient disciples of Jesus Christ Reverend Broughton's educational background includes a Bachelor of Arts Degree from Allen University in Columbia, South Carolina; a Master of Divinity Degree from Payne Theological Seminary in Wilberforce, Ohio; and a Doctor of Ministry Degree from United Theological Seminary in Dayton, Ohio. His future plans are to further his studies at the postdoctoral level and to continue the fight against social, economic, and political oppression of humankind.
Reverend Broughton is married to the former Wendy Geiger of Alexandria Va . His motto is "You can be whatever you want to as long as you put God first." His favorite scripture is Proverbs 3: 5-6: "Trust in the Lord with all thine heart', and lean not unto thine own understanding. In all thy ways acknowledge Him and He shall direct thy path."


text:
Serving residents and businesses throughout the bay area,Calwest Paving Company is a family owned and operated paving company that prides itself on being thorough and delivering quality services. With a reputation for providing a quick turnaround time, we strive for complete customer satisfaction with every paving project that we undertake. We are fully-equipped to perform all types of paving applications, including:
No matter what you need, we can do it! From driveway repairs to new parking lots, you can be confident knowing that we'll go the extra mile for you! Contact us today to get started.


text:
Ellis Craig Sowby arrived on May 23, 2009 at 12:22pm after a VERY long night. He was 7lbs 12oz and 20 inches long. Almost a pound and a half bigger (and 2.5 inches longer) than Suede was. All in all it went well and Mom and family are doing great. Here are a few pics we got today. That makes him... 6 days old.
Friday, May 29, 2009
Thursday, May 7, 2009
Happy Cinco de Mayo! Flan anyone?
In honor of Cinco de Mayo (and some cravings for some custard) I made my first attempt at the beloved flan. I was quite nervous about the outcome. But....I have to boast and say it was AWESOME!!! Looked great and tasted even better. This will have to become a tradition :)
Posted by Taralyn at 8:12 AM 4 comments:
Subscribe to: Posts (Atom)


text:
Our community features distinctive carpets, paint colors, furnishings and decor to increase familiarity, promote relaxation and help make all areas secure, easy to navigate and aesthetically stimulating. Apartments open to a central gathering area, providing residents with a safe access to group activities.
Our Memory Care Center partners are specifically educated in dementia and Alzheimer's programming to assist residents in structured, individualized daily activities. Programming thoughtfully guided by our caregivers will center on meaningful and useful activities that are rewarding and successful for each resident.
We are also delighted to be one of the few certified health centers in Murfreesboro to provide residents access to special programs like Music & Memory, which can be remarkably beneficial for those with cognitive and physical challenges.
Inside and outside, The Memory Care Center at AdamsPlace is a purposefully thought-out home, where residents enjoy their routines, rituals and quality of life. Families enjoy peace of mind in knowing that their loved one is comfortable, safe and in good care.
20th Anniversary and Memory Care Opening
View photos from the event.


text: Stussy is a highly influential streetwear brand, a label that has captured the ethos of hip-hop, dance, skate and street art subcultures since its founding in the 80s. Beginning as a surfboard business in California, Shawn Stussy scribbled his signature onto boards to create a makeshift logo. When he began adding this logo to clothing sold out of his car in Laguna Beach, the iconic brand was born, and can be found today in high-end clothing stores worldwide. Stussy sweats are imbued with the urban attitude of the brand. Scrawled slogans and relaxed, slouchy fits create a laid-back, carefree vibe that is perfect for sports or streetwear.


text:
We are excited to announce that we are now offering the convenience of online registration through partner company,
Here are the following steps you need to know to participate for the fall season.
Go to the school website under Athletic and register online LAST DAY TO REGISTER WILL BE August 10, 2017.
Bring a hard copy of your physical forum to the school. Remember that Physical are only good for 365 days, if yours has expired you cannot participate until school receives new physical.
All athletes must take the baseline concussion test in the computer lab before participating. The following date are Aug 14, 2017 Hackensack Campus.
- 1pm Boys Soccer
- 2pm Girls Soccer
- 3pm Girls Volleyball
- 4pm Cross Country
PAY $30 dollars to the high school secretary.
Practice starts this Monday Aug 15. Boys &Girls soccer will be from 3 to 5 at Johnson Park. Girls volleyball practice is from 4 to 530 at the HS gym. All athletes should wear the proper athletic attire for each sport.
Last step go out and have fun.
Nazmi Mehmedi
Physical Educator & Health
Athletic Coordinator


text:
|First Sex Pistols poster , from German magazine Bravo 1976
Very little point in writing much here. Anyone without knowledge of this band would not be here in the first place.
Here are a handful of shows recorded in 1976 while Glen Matlock was the bass player.
Get them here:


text:
Alphonse Atoll, a nature lover's paradise, is one of the world's most pristine, untouched Edens. The islands in the atoll enjoys an exquisite climate and miles of unblemished shorelines, lagoons and sea flats.
Alphonse is one of three in the group, and sits aside St François and Bijoutier. All enjoy a perfect location in the Seychelles outer islands, in the very heart of the Indian Ocean. Although the accommodation is on Alphonse Island, the fishing is done around St. Francois Island.
What truly distinguishes Alphonse Island as one of the most outstanding fishing destinations in the world is the combination of comfortable hotel accommodation alongside the opportunity to fish 3 different islands right on your doorstep.
Alphonse Atoll is one of the famed saltwater fly fishing destinations of the Indian Ocean. Its ten thousand acres of white sand flats provide easy wading and world class fishing.
The atolls are home to huge populations of bonefish, three different types of triggerfish, barracuda, snapper, grouper, permit, parrotfish and eight species of trevally, including the giant trevally. The most challenging fish to catch, though, is the fabled milkfish, a turbo-charged algae-eater growing to 40lbs.
This diversity gives anglers the opportunity to target a myriad of different species during their stay.
Alphonse Island boasts a single resort made up of Beach Bungalows and Suites. Built alongside the water's edge, each accommodation enjoys spectacular ocean views.
A central dining and bar area lets you socialise alongside the sparkling pool and shoreline, with cuisine offering the very best of traditional Creole creations. Fresh produce farmed on the island and freshly caught fish are always on the menu, but diversity is key, including Asian inspired dishes and sensational sashimi, complemented by a wine list of distinctive variety.
Alphonse Island offers so much more than world-class fishing. This makes this idyllic island the perfect destination for non-fishing partners and families.
Alphonse Island is a true haven for outdoor enthusiasts and nature lovers. There are also bespoke activities to satisfy your every desire, including cycling, guided walks, tennis courts, spa therapies and island hopping.View Detail
There's always more to do on Alphonse Island. Our other recreational activities include dolphin spotting, snorkelling, stand-up paddle boarding, kayaking, windsurfing and paddle boating. There is also tennis, massage therapies and you'll love the complete freedom to explore the wonders of the island on foot or bicycle.View Detail