text:
- Review
- Open Access
Integrating resource defence theory with a neural nonapeptide pathway to explain territory-based mating systems
© Oldfield et al. 2015
- Published: 24 August 2015
The ultimate-level factors that drive the evolution of mating systems have been well studied, but an evolutionarily conserved neural mechanism involved in shaping behaviour and social organization across species has remained elusive. Here, we review studies that have investigated the role of neural arginine vasopressin (AVP), vasotocin (AVT), and their receptor V1a in mediating variation in territorial behaviour. First, we discuss how aggression and territoriality are a function of population density in an inverted-U relationship according to resource defence theory, and how territoriality influences some mating systems. Next, we find that neural AVP, AVT, and V1a expression, especially in one particular neural circuit involving the lateral septum of the forebrain, are associated with territorial behaviour in males of diverse species, most likely due to their role in enhancing social cognition. Then we review studies that examined multiple species and find that neural AVP, AVT, and V1a expression is associated with territory size in mammals and fishes. Because territoriality plays an important role in shaping mating systems in many species, we present the idea that neural AVP, AVT, and V1a expression that is selected to mediate territory size may also influence the evolution of different mating systems. Future research that interprets proximate-level neuro-molecular mechanisms in the context of ultimate-level ecological theory may provide deep insight into the brain-behaviour relationships that underlie the diversity of social organization and mating systems seen across the animal kingdom.
- monogamy
- polygyny
- territory
- V1a
Understanding the causes and consequences of animal behaviour is a fundamental goal in biology [1]. Advances in behavioural ecology, especially during the last three decades of the 20th century, provide an ultimate-level understanding of how ecological and evolutionary forces shape behaviour and social organization (e.g., [2]). At a more proximate level, advances in neuroendocrinology have increased our understanding of the physiological and molecular mechanisms that mediate changes in behaviour in response to ecological and social stimuli [3–6]. However, a conceptual integration of ultimate- and proximate-level perspectives is yet lacking but may provide a more complete understanding of how neuroendocrine mechanisms mediate variation in behaviour and social organisation [7].
In this review we explore the thesis that neural expression of the nonapeptides arginine vasopressin (AVP), vasotocin (AVT) and their receptor V1a may facilitate territoriality, which in turn may shape mating systems in diverse taxa. First, we provide a framework rooted in resource defence theory to illustrate the relationships among aggression, territoriality, and mating system. Next, we consider the relationship between neural AVP, AVT, and V1a and aggression and territoriality and then gather and assess published studies that have examined AVP, AVT, and V1a variation within particular species. We find that neural vasopressinergic and vasotocinergic action is more closely associated with territoriality than it is with outright aggression. Then, we argue that resource defence theory could explain evolution in a neural vasopressinergic or vasotocinergic circuit at the species level, and we review studies that have compared neural AVP, AVT, and V1a between species that differ in territorial behaviour. Because territoriality is a component of the amalgamation of behaviour that we call mating system, we conclude that selection for up-regulation of a neural vasopressinergic or vasotocinergic circuit could mediate territorial behaviour and therefore play a role in the evolution of different resource-based mating systems.
Aggression, territoriality, mating systems
There are many reasons why animals may behave aggressively, and one of the most common reasons is to defend resources [8] such as food [9], shelter [10], and mates and offspring [11]. In contrast, costs of defence might include injury, vulnerability to predators, time spent not exploiting the resource, and energy expended [12]. The decision to defend a resource depends on benefits - costs, which depends on the resource's distribution in space and time [9], on the individual's motivation and its body condition, and on other ecological factors such as number of competitors, available space, habitat complexity, and predation threat [13–16].
It is important to note that other ecological factors can also influence social organization and mating system. Habitat use may influence distribution (animals aggregating in certain areas of the habitat due to unspecific physical factors like thermal environment, humidity, etc.; like bats in caves). The presence of hetero specific competitors or brood predators may restrict territory size or necessitate parental care [27, 29], and high predation threat may cause individuals to aggregate [30]. For example, zebra finches, Taeniopygia guttata, form dense aggregations but are strongly monogamous [31]; most likely as a result of additional ecological factors that are beyond the scope of resource defence.
Here we present a perspective that extends the concept of intra- and inter-individual plasticity and reaction norm to and beyond the species level. Resource defence theory predicts intra-individual plasticity in behaviour. However, the same ecological factors that may lead to plastic behavioural responses in individuals may also lead to evolution in the tendency to behave territorially. This idea is consistent with recent conceptual arguments that suggest that behaviour may evolve by genetic accommodation, in which the degree of plasticity may not change, but the reaction norm of behavior may change in both effect size and in slope [32, 33]. Population size fluctuates in many species [34], and likely attenuates selection for particular patterns of territorial behaviour. However, within a population, individuals vary both in their ability to plastically adjust behaviour according to local ecological conditions experienced at any given time and in their overall tendencies to behave territorially [35]. Therefore, long term changes in both the stability of ecological conditions and the overall typical state of those conditions could select individuals genetically predisposed to more or less readily adjust their behaviour to local conditions and also to tend to behave either less or more territorially in general. This would result in the evolution of differences in the typical patterns of social organization (e.g., scattered, small territories, large territories, aggregations) exhibited by different species [36]. Indeed, interspecies differences in territoriality are well documented [23]. Furthermore, studies that have found that differences between species in territorial behaviour and mating system may remain after ecological manipulation [37] indicate that in at least some species these differences are genetically selected and not simply plastic responses to local ecological conditions (see also [38]).
AVP, AVT, V1A and behaviour
Nonapeptides and receptors that play a role in reproductive behaviour.
Molecule or structure
A nonapeptide associated with reproduction and social bonding. Thought to be most important in females.
The bird/reptile homolog of oxytocin.
The anamniote homolog of oxytocin.
Arginine Vasopressin (AVP)
A nonapeptide associated with aggression, space use, and reproduction. Thought to be most important in males.
Arginine Vasotocin (AVT)
The non-mammalian homolog of AVP.
A cell membrane receptor for AVT and AVP that is commonly associated with social behaviour.
AVP circuit
A collection of neurons that project axons and deliver AVP or AVT to another set of neurons in a different region in the brain.
Mammalian brain regions associated with mating system and their putative homologs in teleost fishes (see [80] for a detailed discussion).
Brain region
Bed Nucleus of the Stria Terminalis (BNST)
Contains cell bodies of AVP- or AVT-producing neurons in tetrapods.
Medial amygdala
Contains cell bodies of AVP- or AVT-producing neurons in tetrapods.
Supracommissural nucleus of the ventral telencephalon (Vs)
Putative teleost homolog of the medial amygdala and BNST, but possesses no AVT-producing cell bodies.
Preoptic Area (POA)
A neuroendocrine integration centre located at the interface of the hypothalamus and telencephalon. Contains groups of AVP- or AVT-producing neuron cell bodies that project axons throughout the brain.
Paraventricular nucleus (parvocellular subdivision in teleosts)
Associated with stress and subordinate behaviour. In teleosts, part of the POA.
Supraoptic nucleus (magno-/gigantocellular subdivision in teleosts)
Associated with aggression and reproductive behaviour. In teleosts, part of the POA.
Lateral septum (LS)
In tetrapods, a collection of neurons in the medial forebrain lying generally anterior to the anterior commissure. Receives axons of AVP- or AVT-producing neurons. Associated with several types of social behaviour.
Ventral nucleus of the ventral telencephalon (Vv)
Putative teleost homolog of the lateral septum.
Ventral pallidum (VP)
A brain region immediately ventral to the lateral septum in tetrapods. Receives axons of AVP- or AVT-producing neurons. Implicated in social pair-bonding in rodents.
One possible explanation for the septal AVP-V1a circuit's stimulatory effect on both affiliation and aggression could be that it more generally enhances social cognition and in doing so stimulates the formation all types of social relationships [55]. Here we define social cognition specifically as the acquisition and retention of social information [56]. Territoriality would seem to require establishing relationships with other individuals (albeit a confrontational context) and the recognition of individuals upon a subsequent encounter. Social cognition may thus be necessary to form and maintain relationships with both mates and offspring and with competitors (such as familiar neighbours or "dear enemies") when maintaining a territory, compared with simply roaming over a broad home range [44, 57–59]. Additionally, holders of large territories are probably continually establishing new relationships as neighbouring individuals change, compared to holders of small territories who have fewer neighbours, or compared to roamers who may encounter many individuals but never form a relationship. Therefore, up-regulation of a neural circuit that stimulates social cognition, specifically the establishment and maintenance of social relationships in specific surroundings, could facilitate both affiliative and aggressive behaviour, depending on social context.
In the sections below, we review studies that have measured aspects of neural AVP, AVT, and/or V1a. The studies are of two general designs: they either measure and compare neural AVP, AVT, and/or V1a between different behavioural phenotypes or they manipulate neural AVP, AVT, and/or V1a and measure the resulting behaviour. Studies that measured neural AVP, AVT, and/or V1a have done so using a variety of different methods. Many studies used immunohistochemistry (e.g., [60]), a laboratory technique used to anatomically visualize the location of a specific protein by using a specific antibody that binds to it. The antibody is visible with a fluorescence microscope when it is bound to a special light-emitting molecule. These studies typically then compare the sizes or numbers of AVP or AVT-immune-reactive (AVP-ir) cells or density of staining within the cells. Some studies measure c-Fos expression in a similar way in addition to the AVP- or AVT-ir (e.g., [61]). Immediate early genes, such as c-Fos, are rapidly and transiently upregulated following an external stimulus. Therefore, increased expression of both AVP or AVT and c-Fos suggest that an AVP- or AVT-expressing neuron is increasing activity in response to a stimulus. Other studies have measured AVP or AVT mRNA. In situ hybridization binds mRNA using a radioactively labelled complementary strand of DNA or RNA (e.g., [62]). Quantitative PCR measures AVP or AVT mRNA by binding it with a light-emitting molecule (e.g., [63]). Finally, a few studies have measured AVT directly using high-performance liquid chromatography; a new application of this method (e.g., [64]). V1a receptors have been identified using autoradiography: binding to a radioactively labelled ligand (e.g., [65]). Many studies that have manipulated neural AVP, AVT, and/or V1a have directly applied AVP, AVT, or V1a antagonist. This has been done by either infusing AVP or V1a antagonist into one of the brain ventricles, (e.g., [66]) or directly injecting AVP or AVT into a specific brain region or into the intraperitoneal cavity (e.g., [67]). A few studies have "knocked down" AVT production in a particular brain region by injecting antisense oligonucleotides that bind to the target mRNA and prevent it from being translated [68].
Intra-species variation in AVP, AVT, V1a and territoriality
A substantial number of studies have examined neural AVP, AVT, and V1a within and among individuals of a particular species. In this section, we review those studies to asses if neural AVP, AVT, or V1a is closely associated with either aggression or territoriality. An association with aggression would indicate a direct relationship between the molecular pathway and aggression. An association with territoriality would suggest that the pathway has a cognitive function, which would better explain the perplexing diversity of behaviours that have been associated with AVP, AVT, and V1a in previous studies. Furthermore, if neural AVP, AVT, or V1a is associated with territoriality within species, then it may also be possible for neural AVP, AVT, and V1a to also be associated with territoriality between species.
Intra-species variation in mammals
Many studies have demonstrated a relationship between neural AVP and V1a and aggression in rodents [44, 69, 70]. Most studies that have investigated the role of AVP or V1a in aggression have relied on resident-intruder tests, which alone are not sufficient to distinguish increases in pure aggressive behaviour from aggression performed specifically as a form of territory defence. However, one study specifically found that in one particular species, the aggression stimulated by neural AVP and V1a is performed not simply to injure or drive away another individual, but to establish a social relationship in the context of a particular place (territory). Bester-Meredith et al. [66] cleverly examined the effects of intracerebroventricularly (ICV) infused AVP and V1a antagonist on aggression in both a resident-intruder test and a neutral arena test. In the monogamous, territorial California mouse, Peromyscus californicus, the antagonist lengthened attack latencies in the resident-intruder test, but had no effect in the neutral arena test. In the promiscuous white-footed mouse, P. leucopus, which does not typically maintain exclusive territories (see Inter-Species Variation in Mammals section below) the antagonist did not alter attack latencies in either test. These results indicate that neural V1a functions specifically in territorial behaviour in California mice but is not a mechanism that strictly increases aggression in either of these species [66].
Additional evidence that the function of neural AVP and V1a extends beyond simply increasing aggression and instead functions specifically to establish social relationships in the context of territoriality can be found in Syrian hamsters, Mesocricetus auratus. Males of this species rub secretions of special glands onto objects in their territories in response to cues from other male hamsters, an activity known as flank marking. AVP injection into the medial preoptic area / anterior hypothalamus, BNST, medial amygdala, and lateral septum of males stimulates flank marking in the absence of other hamsters, and is mediated by V1a in the lateral septum [71–74].
One study has examined the role of septal V1a in natural intra-species variation in space use in male prairie voles. Prairie vole males are typically considered monogamous and territorial, but they may also exhibit a wandering tactic in which they are not site attached but roam and mate opportunistically with females they encounter [75–78]. Within-species comparisons among individual males failed to find a significant difference in septal V1a between territorial males and wandering males [79].
Intra-species variation in birds
The anatomy of the septal AVT circuit in birds is similar to the septal AVP circuit in mammals (see Figure 3 in [80]). In birds, some studies have supported a relationship between neural AVT and V1a and aggression and territoriality and some have not. In a well-studied polymorphism in white-throated sparrows, Zonotrichia albicollis, white-striped males defend their territories more vigorously and intrude into other territories for extra-pair copulations more often than do tan-striped males, and they have more AVT-ir (immune-reactive) expression in the medial portion of the BNST and in the ventrolateral subdivision of the caudal lateral septum [60]. In this species, neural AVT and aggression are clearly associated with a situation in which increased social cognition would benefit a territory-holding male in identifying and remembering nearby males and females.
The relationship between neural AVT and V1a and behaviour is more complex in estrildid finches. In the highly social and monogamous zebrafinch, aggression decreases with time when individuals are group-housed, but is higher in paired compared with unpaired males. Intracerebroventricular AVT injection increases, and V1a antagonist decreases, aggression during competition to court [81, 82]. Furthermore, increases in AVT-Fos are observed in a mate competition paradigm if subjects are allowed to court, but not if they are aggressively subjugated [61]. Kabelik et al. [83] injected a mixture of V1 antagonists into the lateral ventricle and observed a decrease in aggression in unpaired males on the first day of group formation, when aggression was performed as competition over mates. However, paired males increased aggression after the same treatment. In territorial species, the field sparrow, Spizella pusilla [84] and the violet-eared waxbill, Uraeginthus granatina [85] intraseptal AVT infusions inhibit resident-intruder aggression. On the other hand, bilateral knockdown of AVT production in the BNST using antisense oligonucleotides and intraseptal infusions of V1a antagonist in male zebra finches reduced gregariousness: the tendency to associate with a large group (n=10) over a small group (n=2) [68]. The antisense oligonucleotides also decreased exploration behavior in a novel environment [68]. In the moderately gregarious Angolan blue waxbill (Uraeginthus angolensis), bilateral antisense knockdown of AVT production in the BNST reduced social contact, but not gregariousness, especially in males [86]. Thus, in estrildid finches, AVT and V1a of the septal circuit variously promotes aggression, social contact, or gregariousness, suggesting a general social cognition function that varies depending on social context and on species.
Intra-species variation in reptiles and amphibians
The septal AVT circuit in reptiles and amphibians is anatomically similar to the septal AVP circuit in mammals (see Figure 3 in [80]). Neural AVT influences reproductive and aggressive behaviour in reptiles and amphibians [87, 88], and many species in these taxa exhibit territorial behaviour and diverse mating systems [89–91]. Neural AVT is well known to stimulate mate calling in frogs, but two studies specifically observed results pertinent to the role of AVT in territorial behaviour. In staged encounters involving the gray tree frog, Hyla versicolor, intraperitoneal (IP) AVT injection increased an intruder male's ability to acquire calling sites from resident males without physical aggression [67]. Similarly, after IP injection of AVT in the common coquí, Eleutherodactylus coqui, satellite males left the territories of other males and formed their own new territory and began calling [92]. In contrast to this pattern of association between AVT and territoriality, Marler et al. [93] found that satellite males possessed significantly more AVT-ir, in terms of both density of staining within cells and in cell size, in the nucleus accumbens of the brain than did calling males. These studies suggest a role for neural AVT in territoriality in amphibians, but the specific brain regions involved remain unclear.
Intra-species variation in teleost fishes
In teleost fishes, neural AVT and V1a expression have often been associated with aggression and territoriality, although several studies have found an inverse relationship (reviewed by [94]). Some studies in teleosts have observed an association between territorial behaviour and measures of AVT and V1a in distinct forebrain regions that have putative mammalian homologs (Fig. 3B; Table 2; [6]). In teleosts, AVT-expressing neuron cell bodies are located only in the parvocellular, magnocellular, and gigantocellular portions of the preoptic area (POA) and (to a lesser extent) the lateral tuberal nucleus of the hypothalamus [95–98]. Several studies [96, 98–101] have found that aggressive males of a particular species have larger or more numerous AVT-ir cell bodies than do non-aggressive males in the gigantocellular portion of the POA, and sometimes non-aggressive males have more in the parvocellular portion, the putative teleost-homolog of the paraventricular nucleus [3]. In many of these studies, the males compared were specifically identified as being either associated with a specific site or not, so the aggression performed comprised territoriality [96, 98, 100, 101]. One study found larger parvocellular and magnocellular AVT-ir neurons in males of a less aggressive population, but the large size may have been due to due greater function in osmoregulation [102]. Another study found fewer AVT neurons in the magnocellular layer of the POA in territorial individuals after controlling for body size [103], although the pattern was observed in juveniles of a species that undergoes a natural social status-based male to female sex change (clown anemonefish, Amphiprion ocellaris), so reduced AVT might have been indicative of impending female differentiation. Other studies measured AVT mRNA or AVT directly. These have often found higher levels of AVT in the brains of territorial individuals (e.g., [64, 96, 104–106]) although at least one study found no relationship [107].
A general classification of mating system variation with an emphasis on territory defence if it sometimes occurs in a particular mating system [2].
Mating system
Individuals mate with multiple members of the opposite sex, sometimes indiscriminately. Typically there is no pair bonding. Individual home ranges overlap with those of same sex and those of the opposite sex [171,172].
Ongoing mating with a group of multiple mates. Can be subdivided into polygyny and polyandry, depending on which sex is polygamous (2,131,171,172).
A type of polygamy in which one male mates with multiple females. In territorial polygynous systems, each male holds a territory from which other breeding males are typically excluded, and which contains the territories or home ranges of females. The males' territories do not overlap with the territories of other males, and the female territories only overlap with the territory of a single male. Males may mate with the same females in successive mating attempts [171]. Social relationships apparently exist between a territorial male and each female, but they do not spend as much time in coordinated activities as do monogamous pairs. Relatively common [2,172].
A type of polygamy in which one female mates with multiple males for successive breeding attempts. Relatively rare compared to polygyny [2,171].
Members of each sex mate with multiple partners. Not tied to resource defence. Often used instead of "Promiscuity" to distinguish species that do not mate indiscriminately, but may or may not involve ongoing relationships (see "Lek," below).
A type of polygyny or polygynandry[173] in which males form aggregations of small display territories and compete for dominant status during breeding season and females choose among them. Males do not contribute resources or parental care; females visit briefly only to have their eggs fertilized. There are no social bonds [171,174].
A female and a male form a social bond, often mutually defend a territory, and often cooperate to care for their offspring. Environmental constraints prevent either sex from monopolizing more than one member of the opposite sex. Adults remain in close proximity to each other. May be serial, with partners changing with each breeding attempt, or long-term [171,172].
Studies of fish species with alternative male mating tactics have provided opportunities to examine intra-species variation in the role of neural AVT and V1a in territoriality, and have produced contrasting results. In male bluehead wrasses, Thalassoma bifasciatum, territorial males did not have more numerous AVT-ir neurons, but AVT mRNA within magnocellular neurons in territorial males tended to be greater than in the smaller, reproductive but non-territorial male phenotype [113]. Furthermore, qPCR revealed in both whole-brain and hypothalamus samples that V1a2 (one of the two V1a paralogs present in teleosts [114]) was also higher in territorial males [63]. After IP injection with AVT or a V1a receptor antagonist in males, AVT generally increased territorial behaviour and V1a antagonist decreased territorial behaviour, which was not limited to aggression, but also involved remaining at one site instead of roaming, refraining from feeding, and increasing inspections of conspecifics [115]. Furthermore, AVT was necessary to assume territorial status in both non-territorial males and sex-changing females [116]. In contrast, in the plainfin midshipman, Porichthys notatus, dominant, territorial males have AVT-ir neurons in the entire POA that are larger than in smaller, non-territorial sneaking males, which has been interpreted to be an insignificant effect of larger body size. However, non-territorial males have more AVT-ir neurons per body mass [117]. Similarly, if corrected for body mass, the smaller non-nesting males of the Azorean rock-pool blenny, Parablennius parvicornis, have significantly more AVT-ir cells in the entire POA than do the large nesting males [118]. One study was able to distinguish whether neural AVT was more strongly associated with territoriality or courtship toward females [62]. In the peacock blenny, Salaria pavo, territorial males do not perform courtship behaviour [119]. In the entire POA, immunocytochemistry found that there were no differences in body size-corrected AVT-ir cell size or numbers between territorial morphs and sneaking morphs. However, AVT mRNA expression on a per-cell basis using in situ hybridization was higher in sneaker males than in nest-holders, indicating that AVT in this species is associated with courtship behaviour more than it is with territoriality. This is consistent with another study in which IP injections of AVT induced the expression of courtship behaviour in sneakers but not in territorial males [120]. Therefore, in some species, neural AVT and V1a are associated with territoriality, but in others they are more strongly associated with courtship.
Intra-species variation in invertebrates
Little is known about the mechanisms that might underlie aggression and territoriality in invertebrates. In arthropods in particular, many species are territorial [121, 122], and aggressive defence of resources is at least partially mediated by a known molecular mechanism (juvenile hormone) in some species [123]. Distinct nonapeptides are found in different invertebrate taxa [41], including some arthropods such as ants [124, 125], although no such molecules have been found in eusocial honeybees [126]. Oxytocin/vasopressin homologs induce reproductive movements in leeches, worms, and snails [127, 128] and affect learning and memory in cuttlefish [129], but there is at this time no evidence that nonapeptides play a role in territoriality in invertebrates. Research into the neuromolecular mechanisms regulating territoriality in invertebrates is a promising avenue for understanding the evolution of social behaviour.
Interspecies variation in AVP, AVT, V1a and territoriality
Below we review studies that have compared aspects of neural AVP, AVT, or V1a in two or more species that differ in aggression, territoriality, and mating systems and interpret them in the context of resource defence theory. On an inverted-U resource defence function we plot relative expression of neural AVP, AVT, and V1a, using social organization (e.g, scattered, large territories, aggregations) as a proxy for resource density and competitor density, then we evaluate congruency between patterns of neural expression and the species-typical level of territorial behavior (no territories, small territories, large territories) (Fig. 2). Just as our analysis assumes that species-typical patterns of social organization are selected in response to species-typical ecological conditions and population densities, it also assumes that neural AVP, AVT, and V1a are consistent enough within species to persist under the artificial social conditions elicited by a laboratory environment. Indeed, the statistically significant differences between species reported in numerous published studies (see below) suggest that neural expression within a species is consistent enough to persist under artificial socio-ecological conditions (sensu [61]). Many of the studies discussed below are two-species comparisons, which are limited in their ability to allow conclusions about the evolution of traits [130]. However, multiple observations of a particular pattern more strongly indicate that the pattern is a result of evolutionary change and not merely a random difference between species [130].
Inter-species variation in mammals
In studies that compared males of two mammal species, expression patterns in the septal vasopressinergic circuit mirrors territory size. Prairie voles are typically socially monogamous (but see discussion above in the section Intra-Species Variation in Mammals), and male-female pairs usually share a common nest and home range, from which males exclude other males, i.e., a territory [131]. Meadow voles, M. pennsylvanicus, in contrast, are promiscuous and the males are not territorial. Females have small home ranges and distinct territories, but males' home ranges are large and overlap considerably, and males frequently enter the territories of estrous females [132]. The number of male home ranges that overlap with female home ranges is similar to the number of female home ranges that overlap with male home ranges. Wang [133] found that male prairie voles had a higher density of AVP-expressing axons in the lateral septum than did male meadow voles (Fig. 2A). Interestingly, male montane voles, M. montanus, which are polygynous and maintain exclusive, long-term territories that are even larger than those of male prairie voles and which encompass several smaller female territories [134], show even greater expression in the septal vasopressinergic circuit: Comparisons of receptor V1a densities in the lateral septum between prairie voles and montane voles have found higher levels in M. montanus [65, 135, 136]. Therefore, expression of both AVP and V1a in the lateral septum is associated with male territory size in Microtus voles (Fig. 2A).
The vasopressinergic circuit is also associated with territoriality in mice of the genus Peromyscus. These species show variation in territorial behaviour similar to that found in Microtus voles. Mated pairs of the monogamous California mice are strongly territorial, maintaining exclusive home ranges [137]. Males spend more time providing parental care and attack opponents more rapidly than do males of the promiscuous white footed mice [52], which cease to nest with females after the litters are born and provide no paternal care [138]. White footed mice may sometimes aggressively defend their home range as a territory, but only at high densities, and even then there is some overlap among the males' home ranges [139, 140]. In fact, females' home ranges are more strictly exclusive of same-sex individuals than are males' home ranges [139]. Low densities are more common[141], and although under these conditions males' home ranges are exclusive of each other, resident males frequently leave their home ranges to roam in search of females [142], and contact between males is frequent but usually does not involve aggression [141]. Importantly, male California mice show a larger area of neuron cell bodies and axons stained for AVP in the BNST and more V1a receptors in the lateral septum than do male white footed mice([52]; Fig. 2A). Similarly, home ranges of adult deer mice, P. maniculatus, overlap broadly with those of members of the same and opposite sexes, and both males and females are promiscuous [143]. Insel et al. [144] found that male California mice have more V1a receptors in the lateral septum than do male deer mice. In sum, in comparative studies of both Microtus voles and Peromyscus mice, the species that exhibits the greatest exclusive use of space also shows the highest expression in the septal vasopressinergic circuit (Fig. 2A).
Three comparative studies that did not find a positive relationship between neural AVP or V1a and territorial behaviour should be mentioned. First, Wang et al. [145] found that males of the monogamous pine vole, M. pinetorum, had larger areas covered by AVP-expressing axons in the lateral septum than did prairie voles, meadow voles, or montane voles. However, for unknown reasons this study also failed to observe any of the other species differences in expression that had repeatedly been reported in previous studies. Next, Insel et al. [65] found that pine voles had less V1a in the lateral septum compared to the promiscuous meadow voles. However, that study did not analyse males and females separately, which likely obscured any relationship between V1a and territory size that might exist only in males. Finally, Turner et al. [146] failed to find an association between V1a density in the lateral septum and mating system in males of Peromyscus spp. However, their analysis likely suffered from a lack of power due to small sample sizes (only two males of each of five species).
Inter-species variation in birds
In birds, studies have compared neural AVT and V1a in gregarious (aggregating) vs. territorial estrildid finch species. All species of this group are monogamous, so mating system is dissociated from social organisation [3]. Although the septal vasotocinergic circuit has been associated with aggression in some contexts in some species (see Intra-Species Variation in Birds section, above), across species it is more strongly associated with grouping behaviour [3]. Specifically, the gregarious zebra finch and spice finch (Lonchura punctulata) show more AVT-expressing neurons in the BNST, and higher baseline Fos levels and greater social induction of Fos in those AVT neurons than do the territorial species, the Melba finch (Pytilia melba) and the violet-eared waxbill (Uraeginthus granatina). The moderately gregarious species, the "Angolan" blue waxbill (U. angolensis), typically exhibits intermediate values [61]. Similarly, an antagonist known to bind to mammalian V1a was found to bind in several septal areas typically in higher densities in the zebra finch and spice finch than in the Melba finch and the violet-eared waxbill [147]. This pattern seemingly contrasts with the association of septal AVP and V1a and territoriality described above for cricetid rodents (Fig. 2B). However, Goodson & Wang [61] introduced the idea of social valence to explain their findings: septal-circuit AVT and V1a across species is associated with positive interactions and inversely associated with negative interactions. From this perspective, a competitive social interaction and social attraction may both be positive, whereas experiencing aggressive subjugation would be a negative interaction (see also [43, 148] for further discussion of the "social valence" concept).
Inter-species variation in teleost fishes
Similar to the situation described above for cricetid rodents, expression in neural AVT and V1a in the brains of males varies across fish species with characteristically different male territory sizes (in the brain region homologous to the mammalian lateral septum: the ventral nucleus of the ventral telencephalon [area Vv]; see [80]). The coral reef-dwelling butterflyfishes, Chaetodontidae, provide a compelling example. The multiband butterflyfish, Chaetodon multicinctus, is a monogamous species in which the male and female work together to defend feeding territories against competitors [28]. This species does not use the territories for breeding, but the male provides territory defence and thus food to the female, and the female provides reproductive opportunity to the male [26]. The milletseed butterflyfish, C. miliaris, in contrast, is a pelagic species that schools and breeds promiscuously in groups [28]. Dewan et al. [95] found that males of the territorial multiband butterflyfish had larger AVT-expressing neuron cell bodies (in the gigantocellular and magnocellular regions of the POA) and higher AVT-expressing axon densities (in area Vv) than did the non-territorial milletseed butterflyfish (Fig. 2C). Dewan et al. later [149] compared males of seven butterflyfish species and confirmed quantitatively that the number and size of AVT-ir cells in the gigantocellular preoptic cell group and the density of AVT-ir varicosities in the Vv were generally greater in those species with mating systems characterised by male territories.
A recent study by Oldfield et al. [150] compared males of two heroine cichlid species with different mating systems: the Cuatro Ciénegas cichlid, Herichthys minckleyi, in which males are polygynous and maintain large territories, and the Rio Grande cichlid, H. cyanoguttatus, in which males form monogamous pair-bonds with females and defend small, temporary nesting territories [38]. These authors found that neural expression of V1a2 in males was associated with territory size. Specifically, in gross-dissected tissue containing the gigantocellular and magnocellular regions of the POA, V1a2 mRNA in territorial male Cuatro Ciénegas cichlids was higher than in territorial male Rio Grande cichlids and non-reproductive males of either species [150]. Even though anatomical resolution was limited in this study, the pattern of higher neural V1a2 expression in males in species in which males have larger territories is similar to that observed by Dewan et al. [95, 149], and suggests a similar, and possibly conserved, mechanism in different teleost families (Fig. 2C). Furthermore, this neural mechanism underlying variation in territory sizeis at least in part conserved between mammals and teleost fishes even though patterns of territoriality have clearly evolved independently [6, 38].
The results of our analysis indicate that neural vasopressinergic and vasotocinergic action facilitates territoriality, which in turn may shape mating systems. We found that, within species, neural AVP, AVT, and V1a are often associated with territorial behaviour. Similarly, among species, we found that neural AVP, AVT, and V1a are associated with territorial behaviour in a pattern consistent with resource defence theory. This suggests that ecological pressures may, through natural selection, drive up- or down-regulation of expression in a particular neural circuit that stimulates territorial behaviour, resulting in the evolution of differences in reaction norms between species. Because territorial behaviour can influence the acquisition of mates, then such a neural circuit may also influence the evolution of mating systems.
One possible reason that neural AVP, AVT, or V1a expression might be higher in territorial individuals may be because it directly stimulates outright aggressive behaviour (reviewed by [70]). However, several studies indicate that AVP, AVT, and V1a do not necessarily stimulate aggressive behaviour but instead initiate an aggressive disposition, which might be beneficial during the establishment of a social relationship. Although male prairie voles ICV-infused with a V1a antagonist failed to develop a typical increase in aggressive behaviour after co-habitation with a female, aggression was not reduced in males that had previously-established pair-bonds with females [48]. Decreases in aggression caused by nonapeptide antagonists in birds and fishes were also restricted to occurring during establishment of a relationship but not after a relationship had formed [83, 108]. Furthermore, although Oldfield et al. [150] found neural V1a2 expression to be associated with territory size in two species of cichlid fishes, raw numbers of aggressive acts compared between territorial males of each species were negatively associated with V1a2 [38]. Therefore, although neural AVP, AVT, and V1a may stimulate aggression in mammals, birds, and fishes, it seems to do so primarily during the formation of social relationships and not necessarily in other contexts.
The role of neural AVP, AVT, and V1a in the formation of social relationships could be related to its known role in general social cognition. AVP and V1a in the lateral septum are well known to facilitate social memory [55]. For example, in rats, V1a agonists injected into the lateral septum facilitate, but V1a antagonists and AVP anti-sense DNA inhibit, the memory of same-sex conspecifics and familiar juveniles [151]. The association described above between AVT and V1a in the septal circuit and gregariousness in finches is consistent with this idea – the tendency of gregarious animals to approach other individuals and to choose to associate with large groups over small groups is similar to the tendency of animals with large territories (compared to animals with small territories or roaming-tactic species) to establish social relationships [152]. Thompson & Walton [153] found that AVT ICV-administered to highly social individual male goldfish, Carassius auratus, inhibited social approach toward same-sex conspecifics, but treatment with an AVT receptor antagonist stimulated social approach [153], but this mechanism was later found to be mediated by a different circuit in the hindbrain [154]. Therefore, neural AVP, AVT, and V1a, at least in one circuit in the forebrain, seems to be responsible for generally positive-valence behaviour important for establishing social relationships, which may include aggression, but also territoriality (independent of aggression), and gregariousness.
Ophir [5] proposed a two-axis interaction between social bonding and social spacing that determines overall social behaviour, such that seemingly contradictory aspects of social behaviour may in fact arise from the coordinated action of multiple vasopressinergic circuits in the brain (see also [3, 96]). The finding that V1a receptors are widely distributed throughout the vertebrate brain [155–158] and that this expression pattern is highly conserved across vertebrates [159], is consistent with the notion that AVP (or AVT) and V1a expression in different brain regions likely mediates different behavioural processes such as social bonding and territoriality in a manner that is similar across lineages [3, 6, 94, 96, 148, 160]. The septal vasopressinergic or vasotocinergic circuit could variably stimulate additional downstream circuits, each of which are more directly responsible for either affiliative or aggressive behaviour. Alternatively, there may be subdivisions within the septal vasopressinergic or vasotocinergic circuit that are differentially responsible for stimulating different forms of social behaviour [161].
We also found that, at least in mammals and fishes, differences between species' mating systems are consistent with differences in neural AVP, AVT, and V1a expression. Despite the apparent connection with monogamy in prairie voles [48], across different vole species the association between the septal vasopressinergic circuit and monogamy has not appeared to be very robust: the higher abundance of V1a in the lateral septum in M. montanus than in M. ochrogaster [65, 135, 136] had previously been interpreted to be inconsistent with the idea that the septal vasopressinergic circuit was associated with mating system across species [3, 5]. To reconcile these disparate results, Goodson and Bass [162] proposed the idea that V1a expression in the lateral septum of cricetid rodents is consistent with the patterns of space use observed in different mating systems (i.e., home range size and overlap), but not with pair bonding. The current work expands this idea by showing how stimulation of a neural vasopressinergic or vasotocinergiccircuit could enhance social cognition and the formation of social relationships, thereby facilitating territorial ownership and influencing mating systems in those species in which males may defend resources in order to mate. It is important to note, however, that these factors do not necessarily interact in this way to determine mating system in all species. In some species, other ecological factors (such as high predation threat or need for parental care) may play a key role in shaping social organization and mating system. In estrildid finches, overall social organization is dissociated from mating system. Species may exhibit territorial or aggregating social organizations, but all are monogamous. Thus it is not surprising that septal circuit AVT and V1a do not predict territoriality or mating system in these species.
Although the septal vasopressinergic or vasotocinergic circuit has clearly been found to be responsible for stimulating affiliative and gregarious behaviour, pair bonding in male Microtus spp. is likely mediated not by the lateral septum but by the ventral pallidum, a region immediately ventral to the lateral septum [163]. Although males of the polygynous M. montanus have higher V1a densities in the lateral septum than do monogamous male M. ochrogaster, the latter have higher densities of V1a in the ventral pallidum [164]. Blocking the binding sites of V1a in the ventral pallidum prevented mating-induced preference for a particular female partner in male M. ochrogaster [163], and experimental induction of V1a receptor expression in the ventral pallidum of M. pennsylvanicus dramatically increased partner-preference in this normally promiscuous species [164]. Young & Wang [163] proposed that pair bonding in M. ochrogaster is caused by an interaction between AVP in the ventral pallidum that causes partner preference and AVP in the lateral septum that causes partner recognition (in combination with dopamine in the nucleus accumbens). A teleost fish homolog of the mammalian ventral pallidum has not yet been conclusively identified [80], but a recent developmental and neurochemical study suggests that it may be the caudal portion of area Vv [165]. Additionally, recent evidence has found that monogamous male prairie voles expressed higher OT receptor density in the nucleus accumbens than did non-monogamous males [166], a pattern proposed previously to be important to elicit mating-induced partner preference in females [163]. It will thus be fruitful to examine whether a similar pair-bonding circuit may be present in other vertebrate taxa, and whether it involves AVP, AVT, or OT or isotocin [167].
To fully understand the mechanisms underlying different mating systems, more data are needed from females. Female behaviour plays an important role in shaping mating systems. In many species females maintain territories that may or may not be congruent with male territories (see examples provided above for cricetid rodents), and mating systems emerge from conflict between male and female interests [168]. Unfortunately, we have not found published data on the relationship between nonapeptides and territorial behaviour in females. It seems likely that a neural mechanism underlying space use in females might involve OT, which has been found to vary with social structure in tuco-tucos [169]. In fact, OT has recently been found to activate V1a receptor and weakly stimulate flank marking in male Syrian hamsters, so it may play a role in shaping mating systems in males as well [170].
In sum, we have identified an association between a proximate-level neuro-endocrine mechanism and an ultimate-level behaviour pattern that has a direct effect on the social organization of populations. Specifically, neural AVP, AVT, and V1a are associated with territorial behaviour in males, and the most parsimonious explanation for the role of AVP, AVT, and V1a in territorial behaviour is to stimulate social cognition, not necessarily aggression. Furthermore, we have applied the concept of intra- and inter-individual plasticity and reaction norm to evolutionary patterns at and above the species level. Because mating in some species involves territorial behaviour, neural AVP, AVT, and V1a also seem to mediate mating system in both mammals and teleost fishes, but not in the bird species studied to date. Territorial behaviour is most likely one key trait driving resource defence-based mating systems, whereas mating systems are emergent properties arising from the presence or absence of territorial behaviour, pair bonding behaviour, parental behaviour, and perhaps other, less obvious, types of social behaviour. Each one of these types of behaviour is most likely stimulated by one particular (nonapeptide) neural circuit. We expect that interdisciplinary integration of ultimate- and proximate-level perspectives will continue to improve our understanding of social behaviour in the future [7]. Additional comparative studies that include a detailed understanding of social organisation, isolate a single aspect of behaviour, such as pair bonding, and employ a fine resolution of brain anatomy have a promising outlook for identifying discrete nonapeptide circuits and characterising their particular contributions to larger, emergent forms of social behaviour.
We thank Mike Benard, Jean Burns, David Zheng, Adam Dewan, and several anonymous reviewers for commenting on earlier versions of this manuscript and members of the Hofmann laboratory, as well as Alex Ophir and Steven Phelps, for discussions. James Grant kindly provided advice on our integration of mating systems into the inverted-U framework. This work was supported by an Engineering Plus NSF-ADVANCE Opportunity grant to R.G.O., and NSF Grants IOS-0843712 and IOS-1354942, an Alfred P. Sloan Foundation Fellowship, the Dwight W. and Blanche Faye Reeder Centennial Fellowship in Systematic and Evolutionary Biology, and an Institute for Cellular and Molecular Biology Fellowship to H.A.H.
Authors' Affiliations
- Tinbergen N: On aims and methods of ethology. Z Tierpsychol. 1963, 20: 410-433.Google Scholar
- Emlen ST, Oring LW: Ecology, sexual selection, and the evolution of mating systems. Science. 1977, 197: 215-223. 10.1126/science.327542.PubMedGoogle Scholar
- Goodson JL: Nonapeptides and the evolutionary patterning of sociality. Prog Brain Res. 2008, 170: 3-15.PubMed CentralPubMedGoogle Scholar
- Hofmann HA: The neuroendocrine action potential. Horm Behav. 2010, 58: 555-562. 10.1016/j.yhbeh.2010.06.012.PubMedGoogle Scholar
- Ophir AG: Towards meeting Tinbergen's challenge. Horm Behav. 2011, 60: 22-27. 10.1016/j.yhbeh.2011.03.012.PubMedGoogle Scholar
- O' Connell LA, Hofmann HA: Genes, hormones, and circuits: an integrative approach to the study the evolution of social behavior. Front Neuroendocrinol. 2011, 32: 320-325. 10.1016/j.yfrne.2010.12.004.Google Scholar
- Hofmann HA, Beery AK, Blumstein DT, Couzin ID, Earley RL, Hayes LD, et al: An evolutionary framework for studying mechanisms of social behavior. Trends Ecol Evol. 2014, 29: 581-589. 10.1016/j.tree.2014.07.008.PubMedGoogle Scholar
- Huntingford FA, Turner AK: Animal conflict. 1987, London: Chapman and HallGoogle Scholar
- Grand TC, Grant JWA: Spatial predictability of food influences its monopolization and defence by juvenile convict cichlids. Anim. Behav. 1994, 47: 91-100. 10.1006/anbe.1994.1010.Google Scholar
- Gray SJ, Jensen SP, Hurst JL: Structural complexity of territories: preference, use of space and defence in commensal house mice Mus domesticus. Anim Behav. 2000, 60: 765-772. 10.1006/anbe.2000.1527.PubMedGoogle Scholar
- Warner RR, Hoffman SG: Population density and the economics of territorial defence in a coral reef fish. Ecol. 1980, 61: 772-780. 10.2307/1936747.Google Scholar
- Grant JWA: Territoriality. Behavioural ecology of teleost fishes. Edited by: Godin J-GJ, editor. 1997, Oxford: Oxford University Press, 81-103.Google Scholar
- Brown JL: The evolution of diversity in avian territorial systems. Wilson Bull. 1964, 76: 160-169.Google Scholar
- Grant JWA: Whether or not to defend? The influence of resource distribution. Mar Behav Physiol. 1993, 22: 137-153. 10.1080/10236249309378862.Google Scholar
- Maher CR, Lott DF: A review of ecological determinants of territoriality within vertebrate species. Amer Mid Natural. 2000, 143: 1-29. 10.1674/0003-0031(2000)143[0001:AROEDO]2.0.CO;2.Google Scholar
- Oldfield RG: Aggression and welfare in a common aquarium fish, the Midas cichlid. J Appl Anim Wel Sci. 2011, 14: 340-360. 10.1080/10888705.2011.600664.Google Scholar
- Oldfield RG: Behavioral interaction, body size, and sex determination in the Midas cichlid Amphilophus citrinellus. J Fish Internat. 2007, 2: 242-249.Google Scholar
- Fretwell SD, Lucas HL: On territorial behaviour and other factors influencing habitat distribution in birds. I. Theoretical development. Act Biotheoretic. 1969, 19: 16-36. 10.1007/BF01601953.Google Scholar
- Ens BJ, Weissing FJ, Drent RH: The despotic distribution and deferred maturity: two sides of the same coin. Amer Natural. 1995, 146: 625-650. 10.1086/285818.Google Scholar
- Pitcher TJ: Functions of shoaling behaviour in teleosts. The behaviour of teleost fishes. Edited by: Pitcher TJ. 1986, London: Croom Helm, 294-337. 10.1007/978-1-4684-8261-4_12.Google Scholar
- Hoare DJ, Couzin ID, Godin J-GJ, Krause J: Context-dependent group size choice in fish. Anim Behav. 2004, 67: 155-164. 10.1016/j.anbehav.2003.04.004.Google Scholar
- Shuster SM, Wade MJ: Mating systems and strategies. 2003, Princeton: Princeton University PressGoogle Scholar
- Schradin C, Kinahan AA, Pillay N: Cooperative breeding in groups of synchronously mating females and evolution of large testes to avoid sperm depletion in African striped mice. Biol Reprod. 2009, 81: 111-117. 10.1095/biolreprod.108.075838.PubMedGoogle Scholar
- Mock DW, Fujioka M: Monogamy and long-term pair bonding in vertebrates. Trends Ecol Evol. 1990, 5: 39-43. 10.1016/0169-5347(90)90045-F.PubMedGoogle Scholar
- Barlow GW: A comparison of monogamy among freshwater and coral reef fishes. Indo-Pacific Fish Biology: Proceedings of the Second International Conference on Indo-Pacific Fishes. Edited by: Uyeno T, Arai R, Taniuchi T, Matsuura K. 1986, Tokyo: Ichthyological Society of Japan, 767-775.Google Scholar
- Whiteman EA, Côté IM: Monogamy in marine fishes. Biol Rev. 2004, 79: 351-375. 10.1017/S1464793103006304. doi: 10.1017/S1464793103006304PubMedGoogle Scholar
- McKaye KR: Competition for breeding sites between the cichlid fishes of Lake Jiloa, Nicaragua. Ecol. 1977, 58: 291-302. 10.2307/1935604.Google Scholar
- Hourigan TF: Environmental determinants of butterflyfish social systems. Envir Biol Fish. 1989, 25: 61-78. 10.1007/BF00002201.Google Scholar
- Kvarnemo C, Ahnesjö I: The dynamics of operational sex ratios and competition for mates. Trends Ecol Evol. 1996, 11: 404-408. 10.1016/0169-5347(96)10056-2.PubMedGoogle Scholar
- Magurran AE: The adaptive significance of schooling as an anti-predator defence in fish. Ann Zool Fenn. 1990, 27: 51-66.Google Scholar
- Zann RA: The zebra finch - a synthesis of field and laboratory studies. 1996, Oxford: Oxford University PressGoogle Scholar
- Foster SA: Evolution of behavioural phenotypes: influences of ancestry and expression. Anim Behav. 2013, 85: 1061-1075. 10.1016/j.anbehav.2013.02.008.Google Scholar
- Renn SC, Schumer ME: Genetic accommodation and behavioural evolution: insights from genomic studies. Anim Behav. 2013, 85: 1012-1022. 10.1016/j.anbehav.2013.02.012.Google Scholar
- Krebs CJ: Population fluctuations in rodents. 2013, Chicago: University of Chicago PressGoogle Scholar
- Dingemanse NJ, Wolf M: Between-individual differences in behavioural plasticity within populations: causes and consequences. Anim Behav. 2013, 85: 1031-1039. 10.1016/j.anbehav.2012.12.032.Google Scholar
- Blomberg SP, Garland T: Tempo and mode in evolution: phylogenetic inertia, adaptation and comparative methods. J Evol Biol. 2002, 15: 899-910. 10.1046/j.1420-9101.2002.00472.x.Google Scholar
- Oldfield RG, Mandrekar K, Nieves MX, Hendrickson DA, Chakrabarty P, Swanson BO, et al: Parental care in the Cuatro Ciénegas cichlid Herichthys minckleyi (Teleostei: Cichlidae). Hydrobiol. 2015, 748: 233-257. 10.1007/s10750-014-2081-4.Google Scholar
- Schradin C, Lindholm AK, Johannesen J, Schoepf I, Yuen C-H, König B, et al: Social flexibility and social evolution in mammals: a case study of the African striped mouse (Rhabdomys pumilio). Molec Ecol. 2012, 21: 541-553. 10.1111/j.1365-294X.2011.05256.x.Google Scholar
- Young LJ, Flanagan-Cato LM: Oxytocin, vasopressin and social behavior. HormBehav. 2012, 63: 227-462.Google Scholar
- Choleris E, Pfaff DW, Kavaliers M: Oxytocin, vasopressin, and related peptides in the regulation of behavior. 2013, Cambridge: Cambridge University PressGoogle Scholar
- Donaldson ZR, Young LJ: Oxytocin, vasopressin, and the neurogenetics of sociality. Sci. 2008, 322: 900-4. 10.1126/science.1158668.Google Scholar
- Ross HE, Freeman SM, Spiegel LL, Ren X, Terwilliger EF, Young LJ: Variation in oxytocin receptor density in the nucleus accumbens has differential effects on affiliative behaviors in monogamous and polygamous voles. J Neurosci. 2009, 29: 1312-1318. 10.1523/JNEUROSCI.5039-08.2009.PubMed CentralPubMedGoogle Scholar
- Goodson JL, Thompson RR: Nonapeptide mechanisms of social cognition, behavior and species-specific social systems. Curr Opin Neurobiol. 2010, 20: 784-794. 10.1016/j.conb.2010.08.020.PubMedGoogle Scholar
- Albers HE: The regulation of social recognition, social communication and aggression: vasopressin in the social behavior neural network. Horm Behav. 2012, 61: 283-292. 10.1016/j.yhbeh.2011.10.007.PubMedGoogle Scholar
- De Vries GJ, Buijs RM: The origin of vasopressinergic and oxytocinergic innervation of the rat brain with special reference to the lateral septum. Brain Res. 1983, 273: 307-317. 10.1016/0006-8993(83)90855-7.PubMedGoogle Scholar
- Caffe' AR, Van Leeuwen FW, Luiten PGM: Vasopressin cells in the medial amygdala of the rat project to the lateral septum and ventral hippocampus. J Comp Neurol. 1987, 261: 237-252. 10.1002/cne.902610206.Google Scholar
- Freeman SM, Young L: Oxytocin, vasopressin, and the evolution of mating systems in mammals. Oxytocin, vasopressin, and related peptides in the regulation of behaviour. Edited by: Choleris E, Pfaff DW, Kavaliers M. 2013, Cambridge: Cambridge University Press, 128-147.Google Scholar
- Winslow JT, Hastings N, Carter CS, Harbaugh CR, Insel TR: A role for central vasopressin in pair bonding in monogamous prairie voles. Nat. 1993, 365: 545-8. 10.1038/365545a0.Google Scholar
- Wang Z, Ferris CF, De Vries GJ: Role of septal vasopressin innervation in paternal behavior in prairie voles (Microtus ochrogaster). Proc Nat Acad Sci USA. 1994, 91: 400-404. 10.1073/pnas.91.1.400.PubMed CentralPubMedGoogle Scholar
- Young LJ, Nilsen R, Waymire KG, MacGregor GR, Insel TR: Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole. Nat. 1999, 400: 766-768. 10.1038/23475.Google Scholar
- Liu Y, Curtis JT, Wang Z: Vasopressin in the lateral septum regulates pair bond formation in male prairie voles (Microtus ochrogaster). Behav Neurosci. 2001, 115: 910-919.PubMedGoogle Scholar
- Bester-Meredith JK, Young LJ, Marler CA: Species differences in paternal behavior and aggression in Peromyscus and their associations with vasopressin immunoreactivity and receptors. Horm Behav. 1999, 36: 25-38. 10.1006/hbeh.1999.1522.PubMedGoogle Scholar
- De Vries GJ: Sex differences in vasopressin and oxytocin innervation of the brain. Prog Brain Res. 2008, 170: 17-27. http://dx.doi.org/10.1016/S0079-6123(08)00402-0PubMedGoogle Scholar
- van Anders SM, Goldey KL, Kuo PX: The steroid/peptide theory of social bonds: integrating testosterone and peptide responses for classifying social behavioral contexts. Psychoneuroendocrinol. 2011, 36: 1265-1275. 10.1016/j.psyneuen.2011.06.001.Google Scholar
- Dore R, Phan A, Clipperton-Allen AE, Kavaliers M, Choleris E: The involvement of oxytocin and vasopressin in social recognition and social learning: interplay with the sex hormones. Oxytocin, vasopressin, and related peptides in the regulation of behaviour. Edited by: Choleris E, Pfaff DW, Kavaliers M. 2013, Cambridge: Cambridge University Press, 232-255.Google Scholar
- Ferguson JN, Young LJ, Insel TR: The neuroendocrine basis of social recognition. FrontNeuroendocrinol. 2002, 23: 200-224.Google Scholar
- Temeles EJ: The role of neighbors in territorial systems: when are they 'dear enemies'?. Anim Behav. 1994, 47: 339-350. 10.1006/anbe.1994.1047.Google Scholar
- Bielsky IF, Hu SB, Ren X, Terwilliger EF, Young LJ: The V1a vasopressin receptor is necessary and sufficient for normal social recognition: a gene replacement study. Neuron. 2005, 47: 503-513. 10.1016/j.neuron.2005.06.031.PubMedGoogle Scholar
- Weitekamp CA, Hofmann HA: Evolutionary themes in the neurobiology of social cognition. Curr Opin Neurobiol. 2014, 28: 22-7.PubMedGoogle Scholar
- Maney DL, Erwin KL, Goode CT: Neuroendocrine correlates of behavioral polymorphism in white-throated sparrows. Horm Behav. 2005, 48: 196-206. 10.1016/j.yhbeh.2005.03.004.PubMedGoogle Scholar
- Goodson JL, Wang Y: Valence-sensitive neurons exhibit divergent functional profiles in gregarious and asocial species. Proc Nat Acad Sci USA. 2006, 103: 17013-7. 10.1073/pnas.0606278103.PubMed CentralPubMedGoogle Scholar
- Grober MS, George AA, Watkins KK, Carneiro LA, Oliveira RF: Forebrain AVT and courtship in a fish with male alternative reproductive tactics. Brain Res Bull. 2002, 57: 423-5. 10.1016/S0361-9230(01)00704-3.PubMedGoogle Scholar
- Lema SC, Slane MA, Salvesen KE, Godwin J: Variation in gene transcript profiles of two V1a-type arginine vasotocin receptors among sexual phases of bluehead wrasse (Thalassoma bifasciatum). Gen Comp Endocrinol. 2012, 179: 451-464. 10.1016/j.ygcen.2012.10.001.PubMedGoogle Scholar
- Kleszczyńska A, Sokołowska E, Kulczykowska E: Variation in brain arginine vasotocin (AVT) and isotocin (IT) levels with reproductive stage and social status in males of three-spined stickleback (Gasterosteus aculeatus). Gen Comp Endocrinol. 2012, 175: 290-296. 10.1016/j.ygcen.2011.11.022.PubMedGoogle Scholar
- Insel TR, Wang ZX, Ferris CF: Patterns of brain vasopressin receptor distribution associated with social organization in microtine rodents. J Neurosci. 1994, 14: 5381-5392.PubMedGoogle Scholar
- Bester-Meredith JK, Martin PA, Marler CA: Manipulations of vasopressin alter aggression differently across testing conditions in monogamous and non-monogamous Peromyscus mice. Aggress Behav. 2005, 31: 189-199. 10.1002/ab.20075.Google Scholar
- Semsar K, Klomberg KF, Marler C: Arginine vasotocin increases calling-site acquisition by nonresident male grey treefrogs. Anim Behav. 1998, 56: 983-7. 10.1006/anbe.1998.0863.PubMedGoogle Scholar
- Kelly AM, Kingsbury MA, Hoffbuhr K, Schrock SE, Waxman B, Kabelik D, et al: Vasotocin neurons and septal V1a-like receptors potently modulate songbird flocking and responses tonovelty. Horm Behav. 2011, 60: 12-21. 10.1016/j.yhbeh.2011.01.012.PubMed CentralPubMedGoogle Scholar
- Veenema AH, Beiderbeck DI, Lukas M, Neumann ID: Distinct correlations of vasopressin release within the lateral septum and the bed nucleus of the stria terminalis with the display of intermale aggression. Horm Behav. 2010, 58: 273-281. 10.1016/j.yhbeh.2010.03.006.PubMedGoogle Scholar
- Pagani JH, Wersinger SR, Young WS: The roles of vasopressin and oxytocin in aggression. Oxytocin, vasopressin, and related peptides in the regulation of behaviour. Edited by: Choleris E, Pfaff DW, Kavaliers M. 2013, Cambridge: Cambridge University Press, 193-212.Google Scholar
- Ferris CF, Albers HE, Wesolowski SM, Goldman BD, Leeman SE: Vasopressin injected into the hypothalamus triggers a stereotypic behavior in golden hamsters. Sci. 1984, 224: 521-3. 10.1126/science.6538700.Google Scholar
- Ferris CF, Pollock J, Albers HE, Leeman SE: Inhibition of flank-marking behavior in golden hamsters by microinjection of a vasopressin antagonist into the hypothalamus. Neurosci Lett. 1985, 55: 239-243. 10.1016/0304-3940(85)90027-8.PubMedGoogle Scholar
- Irvin RW, Szot P, Dorsa DM, Potegal M, Ferris CF: Vasopressin in the septal area of the golden hamster controls scent marking and grooming. Phys Behav. 1990, 48: 693-9. 10.1016/0031-9384(90)90213-N.Google Scholar
- Bamshad M, Albers E: Neural circuitry controlling vasopressin-stimulated scent marking in Syrian hamsters (Mesocricetus auratus). J Comp Neurol. 1996, 369: 252-263. 10.1002/(SICI)1096-9861(19960527)369:2<252::AID-CNE6>3.0.CO;2-2.PubMedGoogle Scholar
- McGuire B, Getz L: The nature and frequency of social interactions among free-living prairie voles (Microtus ochrogaster). Behav Ecol Sociobiol. 1998, 43: 271-9. 10.1007/s002650050491.Google Scholar
- McGuire B, Getz LL: Alternative male reproductive strategies in a natural population of prairie voles (Microtus ochrogaster). Act Theriolog. 2010, 55: 261-270. 10.4098/j.at.0001-7051.077.2009.Google Scholar
- Solomon NS, Jacquot JJ: Characteristics of resident and wandering prairie voles Microtus ochrogaster. Canad J Zool. 2002, 80: 951-5. 10.1139/z02-053.Google Scholar
- Ophir AG, Phelps SM, Sorin AB, Wolff JO: Social but not genetic monogamy is associated with greater breeding success in prairie voles. Anim Behav. 2008, 75: 1143-1154. 10.1016/j.anbehav.2007.09.022.Google Scholar
- Ophir AG, Wolff JO, Phelps SM: Variation in neural V1aR predicts sexual fidelity and space use among prairie voles in semi-natural settings. Proc Nat Acad Sci USA. 2008, 105: 1249-1254. 10.1073/pnas.0709116105.PubMed CentralPubMedGoogle Scholar
- O' Connell LA, Hofmann HA: The vertebrate mesolimbic reward system and social behavior network: a comparative synthesis. J Comp Neurol. 2011, 519: 3599-3639. 10.1002/cne.22735.Google Scholar
- Goodson JL, Adkins-Regan E: Effect of intraseptal vasotocin and vasoactive intestinal polypeptide infusions on courtship song and aggression in the male zebra finch (Taeniopygia guttata). J Neuroendocrinol. 1999, 11: 19-25.PubMedGoogle Scholar
- Goodson JL, Lindberg L, Johnson P: Effects of central vasotocin and mesotocin manipulations on social behavior in male and female zebra finches. Horm Behav. 2004, 45: 136-143. 10.1016/j.yhbeh.2003.08.006.PubMedGoogle Scholar
- Kabelik D, Klatt JD, Kingsbury MA, Goodson JL: Endogenous vasotocin exerts context-dependent behavioral effects in a semi-naturalistic colony environment. Horm Behav. 2009, 56: 101-7. 10.1016/j.yhbeh.2009.03.017.PubMed CentralPubMedGoogle Scholar
- Goodson JL: Territorial aggression and dawn song are modulated by septal vasotocin and vasoactive intestinal polypeptide in male field sparrows (Spizella pusilla). Horm Behav. 1998, 34: 67-77. 10.1006/hbeh.1998.1467.PubMedGoogle Scholar
- Goodson JL: Vasotocin and vasoactive intestinal polypeptide modulate aggression in a territorial songbird, the violet-eared waxbill (Estrildidae: Uraeginthus granatina). Gen Comp Endocrinol. 1998, 111: 233-244. 10.1006/gcen.1998.7112.PubMedGoogle Scholar
- Kelly AM, Goodson JL: Behavioral relevance of species-specific vasotocin anatomy in gregarious finches. Front Neurosci. 2013, 7: 242-doi: 10.3389/fnins.2013.00242PubMed CentralPubMedGoogle Scholar
- Kime NM, Whitney TK, Davis ES, Marler CA: Arginine vasotocin promotescalling behavior and call changes in male túngara frogs. Brain Behav Evol. 2007, 69: 254-265. 10.1159/000099613.PubMedGoogle Scholar
- Kabelik D, Alix VC, Burford ER, Singh LJ: Aggression- and sex-induced neural activity across vasotocin populations in the brown anole. Horm Behav. 2013, 63: 437-446. 10.1016/j.yhbeh.2012.11.016.PubMedGoogle Scholar
- Kunte K: Natural history and reproductive behavior of Nyctibatrachus cf. humayuni (Family Ranidae: Anura). Herp Rev. 2004, 35: 137-140.Google Scholar
- Rivas JA, Burghardt GM: Snake mating systems, behavior, and evolution: the revisionary implications of recent findings. J Comp Psychol. 2005, 119: 447-454.PubMedGoogle Scholar
- Brown JL, Morales V, Summers K: A key ecological trait drove the evolution of biparental care and monogamy in an amphibian. Amer Natural. 2010, 175: 436-446. 10.1086/650727.Google Scholar
- Eyck Ten GR: Arginine vasotocin activates advertisement calling and movement in the territorial Puerto Rican frog Eleutherodactylus coqui. Horm Behav. 2005, 47: 223-9. 10.1016/j.yhbeh.2004.10.005.PubMedGoogle Scholar
- Marler CA, Boyd SK, Wilczynski W: Forebrain arginine vasotocin correlates of alternative mating strategies in cricket frogs. Horm Behav. 1999, 36: 53-61. 10.1006/hbeh.1999.1524.PubMedGoogle Scholar
- Godwin J, Thompson R: Nonapeptides and social behavior in fishes. Horm Behav. 2012, 61: 230-8. 10.1016/j.yhbeh.2011.12.016.PubMedGoogle Scholar
- Dewan AK, Maruska KP, Tricas TC: Arginine vasotocin neuronal phenotypes among congeneric territorial and shoaling reef butterflyfishes: species, sex, and reproductive season comparisons. J Neuroendocrinol. 2008, 20: 1382-1394. 10.1111/j.1365-2826.2008.01798.x.PubMedGoogle Scholar
- Greenwood AK, Wark AR, Fernald RD, Hofmann HA: Expression of arginine vasotocin in distinct preoptic regions is associated with dominant and subordinate behavior in an African cichlid fish. Proc Roy Soc Lond B. 2008, 275: 2393-2402. 10.1098/rspb.2008.0622.Google Scholar
- Thompson RR, Walton JC: Vasotocin immunoreactivity in goldfish brains: characterizing primitive circuits associated with social regulation. Brain Behav Evol. 2009, 73: 153-164. 10.1159/000219485.PubMedGoogle Scholar
- Ramallo MR, Grober M, Cánepa MM, Morandini L, Pandolfi M: Arginine-vasotocin expression and participation in reproduction and social behavior in males of the cichlid fish Cichlasoma dimerus. Gen Comp Neuroendocrinol. 2012, 179: 221-231. 10.1016/j.ygcen.2012.08.015.Google Scholar
- Larson ET, O' Malley DM, Melloni RH: Aggression and vasotocin are associated with dominant-subordinate relationships in zebrafish. Behav Brain Res. 2006, 167: 94-102. 10.1016/j.bbr.2005.08.020.PubMedGoogle Scholar
- Santangelo N, Bass AH: Individual behavioral and neuronal phenotypes for arginine vasotocin mediated courtship and aggression in a territorial teleost. Brain Behav Evol. 2010, 75: 282-291. 10.1159/000316867.PubMedGoogle Scholar
- Dewan AK, Tricas TC: Arginine vasotocin neuronal phenotypes and their relationship to aggressive behavior in the territorial monogamous multiband butterflyfish Chaetodon multicinctus. Brain Res. 2011, 1401: 74-84.PubMedGoogle Scholar
- Lema SC, Nevitt GA: Variation in vasotocin immunoreactivity in the brain of recently isolated populations of a Death Valley pupfish Cyprinodon nevadensis. Gen Comp Endocrinol. 2004, 135: 300-9. 10.1016/j.ygcen.2003.10.006.PubMedGoogle Scholar
- Iwata E, Nagai Y, Sasaki H: Social rank modulates brain arginine vasotocin immunoreactivity in false clown anemonefish (Amphiprion ocellaris). Fish Physiol Biochem. 2010, 36: 337-345. 10.1007/s10695-008-9298-y.PubMedGoogle Scholar
- Aubin-Horth N, Desjardins JK, Martei YM, Balshine S, Hofmann HA: Masculinized dominant females in a cooperatively breeding species. Molec Ecol. 2007, 16: 1349-1358. 10.1111/j.1365-294X.2007.03249.x.Google Scholar
- Renn SCP, Aubin-Horth N, Hofmann HA: Fish and chips: functional genomics of social plasticity in an African cichlid fish. J Exper Biol. 2008, 211: 3041-3056. 10.1242/jeb.018242.Google Scholar
- Filby AL, Paull GC, Hickmore TF, Tyler CR: Unravelling the neurophysiological basis of aggression in a fish model. BMC Genom. 2010, 11: 498-10.1186/1471-2164-11-498.Google Scholar
- Almeida O, Gozdowska M, Kulczykowska E, Oliveira RF: Brain levels of arginine vasotocin and isotocin in dominant and subordinate males of a cichlid fish. Horm Behav. 2012, 61: 212-7. 10.1016/j.yhbeh.2011.12.008.PubMedGoogle Scholar
- Oldfield RG, Hofmann HA: Neuropeptide regulation of social behavior in a monogamous cichlid fish. Physiol Behav. 2011, 102: 296-303. 10.1016/j.physbeh.2010.11.022.PubMedGoogle Scholar
- Santangelo N, Bass AH: New insights into neuropeptide modulation of aggression: field studies of arginine vasotocin in a territorial tropical damselfish. Proc Roy Soc B. 2006, 273: 3085-3092. 10.1098/rspb.2006.3683.Google Scholar
- Backström T, Winberg S: Arginine-vasotocin influence on aggressive behavior and dominance in rainbow trout. Physiol Behav. 2009, 96: 470-5. 10.1016/j.physbeh.2008.11.013.PubMedGoogle Scholar
- Bastian J, Schniederjan S, Nguyenkim J: Arginine vasotocin modulates a sexually dimorphic communication behavior in the weakly electric fish Apteronotus leptorhynchus. J Exper Biol. 2001, 204: 1909-1923.Google Scholar
- Lema SC, Nevitt GA: Exogenous vasotocin alters aggression during agonistic exchanges in male Amargosa River pupfish (Cyprinodon nevadensis amargosae). Horm Behav. 2004, 46: 628-637. 10.1016/j.yhbeh.2004.07.003.PubMedGoogle Scholar
- Godwin J, Sawby R, Warner RR, Crews D, Grober MS: Hypothalamic arginine vasotocin mRNA abundance variation across sexes and with sex change in a coral reef fish. Brain Behav Evol. 2000, 55: 77-84. 10.1159/000006643.PubMedGoogle Scholar
- Lema SC: Identification of multiple vasotocin receptor cDNAs in teleost fish: sequences, phylogenetic analysis, sites of expression, and regulation in the hypothalamus and gill in response to hyperosmotic challenge. Molec Cell Endocrinol. 2010, 321: 215-230. 10.1016/j.mce.2010.02.015.PubMedGoogle Scholar
- Semsar K, Kandel FL, Godwin J: Manipulations of the AVT system shift social status and related courtship and aggressive behavior in the bluehead wrasse. Horm Behav. 2001, 40: 21-31. 10.1006/hbeh.2001.1663.PubMedGoogle Scholar
- Semsar K, Godwin J: Multiple mechanisms of phenotype development in the bluehead wrasse. Horm Behav. 2004, 45: 345-353. 10.1016/j.yhbeh.2004.01.003.PubMedGoogle Scholar
- Foran CM, Bass AH: Preoptic AVT immunoreactive neurons of a teleost fish with alternative reproductive tactics. Gen Comp Endocrinol. 1998, 111: 271-282. 10.1006/gcen.1998.7113.PubMedGoogle Scholar
- Miranda JA, Oliveira RF, Carneiro LA, Santos RS, Grober MS: Neurochemical correlates of male polymorphism and alternative reproductive tactics in the Azorean rock-pool blenny Parablennius parvicornis. Gen Comp Endocrinol. 2003, 132: 183-9. 10.1016/S0016-6480(03)00063-7.PubMedGoogle Scholar
- Oliveira RF, Ros AF, Gonçalves DM: Intra-sexual variation in male reproduction in teleost fish: a comparative approach. Horm Behav. 2005, 48: 430-9. 10.1016/j.yhbeh.2005.06.002.PubMedGoogle Scholar
- Carneiro LA, Oliveira RF, Canário AVM, Grober MS: The effect of arginine vasotocin on courtship behaviour in a blenniid fish with alternative reproductive tactics. Fish Physiol Biochem. 2003, 28: 241-3. 10.1023/B:FISH.0000030542.31395.8a.Google Scholar
- Hölldobler B: Territoriality in ants. Proc Amer Philosoph Soc. 1979, 123: 211-8.Google Scholar
- Shellman-Reeve JS: Courting strategies and conflicts in a monogamous, biparental termite. Proc Roy Soc B. 1999, 266: 137-144. 10.1098/rspb.1999.0613.Google Scholar
- Scott MP: Resource defense and juvenile hormone: the "challenge hypothesis" extended to insects. Horm Behav. 2006, 49: 276-281. 10.1016/j.yhbeh.2005.07.003.PubMedGoogle Scholar
- Gruber CW, Muttenthaler M: Discovery of defense- and neuropeptides in social ants by genome-mining. PLoS ONE. 2012, 7: e32559-10.1371/journal.pone.0032559. doi: 10.1371/journal.pone.0032559PubMed CentralPubMedGoogle Scholar
- Gruber CW: Physiology of invertebrate oxytocin and vasopressin neuropeptides. Exper Physiol. 2014, 99: 55-61. 10.1113/expphysiol.2013.072561.Google Scholar
- Stafflinger E, Hansen KK, Hauser F, Schneider M, Cazzamali G, Williamson M, et al: Cloning and identification of an oxytocin/vasopressin-like receptor and its ligand from insects. Proc Nat Acad Sci USA. 2008, 105: 3262-7. 10.1073/pnas.0710897105.PubMed CentralPubMedGoogle Scholar
- Fujino Y, Nagahama T, Oumi T, Ukena K, Morishita F, Furukawa Y, et al: Possible functions of oxytocin/vasopressin-super family peptides in annelids with special reference to reproduction and osmoregulation. J Exper Zool. 1999, 284: 401-6. 10.1002/(SICI)1097-010X(19990901)284:4<401::AID-JEZ6>3.0.CO;2-U.Google Scholar
- Wagenaar DA, Hamilton MS, Huang T, Kristan WB, French KA: A hormone-activated central pattern generator for courtship. Curr Biol. 2010, 20: 487-495. 10.1016/j.cub.2010.02.027.PubMed CentralPubMedGoogle Scholar
- Bardou I, Leprince J, Chichery R, Vaudry H, Agin V: Vasopressin/oxytocin-related peptides influence long-term memory of a passive avoidance task in the cuttlefish Sepia officinalis. Neurobiol Learn Mem. 2010, 93: 240-7. 10.1016/j.nlm.2009.10.004.PubMedGoogle Scholar
- Garland T, Adolph SC: Why not to do 2-species comparative studies – limitations on inferring adaptation. Physiol Zool. 1994, 67: 797-828.Google Scholar
- Getz LL, McGuire B, Pizzuto T, Hofmann JE, Frase B: Social organization of the prairie vole Microtus ochrogaster. J Mamm. 1993, 74: 44-58. 10.2307/1381904.Google Scholar
- Madison DM: Space use and social structure in meadow voles. Behav Ecol Sociobiol. 1980, 7: 65-71. 10.1007/BF00302520.Google Scholar
- Wang Z: Species differences in the vasopressin-immunoreactive pathways in the bed nucleus of the stria terminalis and medial amygdaloid nucleus in prairie voles (Microtus ochrogaster) and meadow voles (Microtus pennsylvanicus). Behav Neurosci. 1995, 109: 305-311.PubMedGoogle Scholar
- Jannett FJ: Sex ratios in high-density populations of the montane vole Microtus montanus, and the behavior of territorial males. Behav Ecol Sociobiol. 1981, 8: 297-307. 10.1007/BF00299530.Google Scholar
- Wang ZX, Young LJ, Liu Y, Insel TR: Species differences in vasopressin receptor binding are evident early in development: Comparative anatomic studies in prairie and montane voles. J Comp Neurol. 1997, 378: 535-546. 10.1002/(SICI)1096-9861(19970224)378:4<535::AID-CNE8>3.0.CO;2-3.PubMedGoogle Scholar
- Young LJ, Winslow JT, Nilsen R, Insel TR: Species differences in V1a receptor gene expression in monogamous and nonmonogamous voles: behavioral consequences. Behav Neurosci. 1997, 111: 599-605.PubMedGoogle Scholar
- Ribble DO, Salvioni M: Social organization and nest co-occupancy in Peromyscus californicus, a monogamous rodent. Behav Ecol Sociobiol. 1990, 26: 9-16. 10.1007/BF00174020.Google Scholar
- Svihla A: A comparative life history study of the mice of the genus Peromyscus. Misc Pub Mus Zool Univ Mich. 1932, 24: 1-39.Google Scholar
- Metzgar LH: Behavioral population regulation in the woodmouse Peromyscus leucopus. Amer Mid Natural. 1971, 86: 434-448. 10.2307/2423635.Google Scholar
- Wolff JO: The effects of density, food, and interspecific interference on home range size in Peromyscus leucopus and Peromyscus maniculatus. Can J Zool. 1985, 63: 2657-2662. 10.1139/z85-397.Google Scholar
- Wolff JO: Life history strategies of white-footed mice (Peromyscus leucopus). Virg J Sci. 1986, 37: 208-220.Google Scholar
- Wolff JO, Cicirello DM: Mobility versus territoriallity: alternative reproductive strategies in white-footed mice. Anim Behav. 1990, 39: 1222-4. 10.1016/S0003-3472(05)80799-7.Google Scholar
- Blair WF: A study of prairie deer-mouse populations in Southern Michigan. Amer Mid Natural. 1940, 24: 273-305. 10.2307/2420931.Google Scholar
- Insel TR, Gelhard R, Shapiro LE: The comparative distribution of forebrain receptors for neurohypophyseal peptides in monogamous and polygamous mice. Neurosci. 1991, 43: 623-630. 10.1016/0306-4522(91)90321-E.Google Scholar
- Wang Z, Zhou L, Hulihan T, Insel TR: Immunoreactivity of central vasopressin and oxytocin pathways in microtine rodents: a quantitative comparative study. J Comp Neurol. 1996, 366: 726-737. 10.1002/(SICI)1096-9861(19960318)366:4<726::AID-CNE11>3.0.CO;2-D.PubMedGoogle Scholar
- Turner LM, Young AR, Römpler H, Schöneberg T, Phelps SM, Hoekstra HE: Monogamy evolves through multiple mechanisms: evidence from V1aR in deer mice. Molec Biol Evol. 2010, 27: 1269-1278. 10.1093/molbev/msq013.PubMedGoogle Scholar
- Goodson JL, Evans AK, Wang Y: Neuropeptide binding reflects convergent and divergent evolution in species-typical group sizes. Horm Behav. 2006, 50: 223-236. 10.1016/j.yhbeh.2006.03.005.PubMed CentralPubMedGoogle Scholar
- Ho JM, Murray JH, Demas GE, Goodson JL: Vasopressin cell groups exhibit strongly divergent responses to copulation and male–male interactions in mice. Horm Behav. 2010, 58: 368-377. 10.1016/j.yhbeh.2010.03.021.PubMed CentralPubMedGoogle Scholar
- Dewan AK, Ramey ML, Tricas TC: Arginine vasotocin neuronal phenotypes, telencephalic fiber varicosities, and social behavior in butterflyfishes (Chaetodontidae): potential similarities to birds and mammals. Horm Behav. 2011, 59: 56-66. 10.1016/j.yhbeh.2010.10.002.PubMedGoogle Scholar
- Oldfield RG, Harris R, Hendrickson DA, Hofmann HA: Arginine vasotocin and androgen pathways are associated with mating system variation in North American cichlid fishes. Horm Behav. 2013, 64: 44-52. 10.1016/j.yhbeh.2013.04.006.PubMedGoogle Scholar
- Dantzer R, Koob G, Bluthe R, Le Moal M: Septal vasopressin modulates social memory in male rats. Brain Res. 1988, 457: 143-7. 10.1016/0006-8993(88)90066-2.PubMedGoogle Scholar
- Veenema AH, Neuman ID: Central vasopressin and oxytocin release: regulation of complex social behaviours. Prog Brain Res. 2008, 170: 261-276.PubMedGoogle Scholar
- Thompson RR, Walton JC: Peptide effects on social behavior: effects of vasotocin and isotocin on social approach behavior in male goldfish (Carassius auratus). Behav Neurosci. 2004, 118: 620-6.PubMedGoogle Scholar
- Thompson RR, Walton JC, Bhalla R, George KC, Beth EH: A primitive social circuit: vasotocin-substance P interactions modulate social behavior through a peripheral feedback mechanism in goldfish. Eur J Neurosci. 2008, 27: 2285-2293. 10.1111/j.1460-9568.2008.06210.x.PubMedGoogle Scholar
- Campbell P, Ophir AG, Phelps SM: Central vasopressin and oxytocin receptor distributions in two species of singing mice. J Comp Neurol. 2009, 516: 321-333. 10.1002/cne.22116.PubMedGoogle Scholar
- Kline RJ, O' Connell LA, Hofmann HA, Holt GJ, Khan IA: Immunohistochemical distribution of an AVT V1a receptor in the brain of a sex changing fish Epinephelus adscensionis. J Chem Neuroanat. 2011, 42: 72-88. 10.1016/j.jchemneu.2011.06.005.PubMedGoogle Scholar
- Leung CH, Abebe DF, Earp SE, Goode CT, Grozhik AV, Mididoddi P, et al: Neural distribution of vasotocin receptor mRNA in two species of songbird. Endocrinol. 2011, 152: 4865-4881. 10.1210/en.2011-1394.Google Scholar
- Huffman LS, O' Connell LA, Kenkel CD, Kline RJ, Khan IA, Hofmann HA: Distribution of nonapeptide systems in the forebrain of an African cichlid fish Astatotilapia burtoni. J Chem Neuroanat. 2012, 44: 86-97. 10.1016/j.jchemneu.2012.05.002.PubMedGoogle Scholar
- O' Connell LA, Hofmann HA: Evolution of a vertebrate social decision-making network. Sci. 2012, 336: 1154-7. 10.1126/science.1218889.Google Scholar
- Goodson JL, Kabelik D: Dynamic limbic networks and social diversity in vertebrates: from neural context to neuromodulatory patterning. Front Neuroendocrinol. 2009, 30: 429-441. 10.1016/j.yfrne.2009.05.007.PubMed CentralPubMedGoogle Scholar
- Goodson JL, Evans AK, Lindberg L: Chemoarchitectonic subdivisions of the songbird septum and a comparative overview of septum chemical anatomy in jawed vertebrates. J Comp Neurol. 2004, 473: 293-314. 10.1002/cne.20061.PubMed CentralPubMedGoogle Scholar
- Goodson JL, Bass AH: Social behavior functions and related anatomical characteristics of vasotocin/vasopressin systems in vertebrates. Brain Res Rev. 2001, 35: 246-265. 10.1016/S0165-0173(01)00043-1.PubMedGoogle Scholar
- Young LJ, Wang Z: The neurobiology of pair bonding. Nat Neurosci. 2004, 7: 1048-1054. 10.1038/nn1327.PubMedGoogle Scholar
- Lim MM, Wang Z, Olazabal DE, Ren X, Terwilliger EF, Young LJ: Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene. Nat. 2004, 429: 754-7. 10.1038/nature02539.Google Scholar
- Ganz J, Kaslin J, Freudenreich D, Machate A, Geffarth M, Brand M: Subdivisions of the adult zebrafish subpallium by molecular marker analysis. J Comp Neurol. 2011, 520: 633-655.Google Scholar
- Ophir AG, Gessel A, Zheng D-J, Phelps SM: Oxytocin receptor density is associated with male mating tactics and social monogamy. Horm Behav. 2012, 63: 445-453.Google Scholar
- O' Connell LA, Matthews BJ, Hofmann HA: Isotocin regulates paternal care in a monogamous cichlid fish. Horm Behav. 2012, 61: 725-733. 10.1016/j.yhbeh.2012.03.009.Google Scholar
- Davies NB: Sexual conflict and the polygamy threshold. Anim Behav. 1989, 38: 226-234. 10.1016/S0003-3472(89)80085-5.Google Scholar
- Beery AK, Lacey EA, Francis DD: Oxytocin and vasopressin receptor distributions in a solitary and a social species of tuco-tuco (Ctenomys haigi and Ctenomys sociabilis). J Comp Neurol. 2008, 507: 1847-1859. 10.1002/cne.21638.PubMedGoogle Scholar
- Song Z, McCann KE, McNeill JK, Larkin TE, Huhman KL, Albers HE: Oxytocin induces social communication by activating arginine-vasopressin V1a receptors and not oxytocin receptors. Psychoneuroendocrinol. 2014, 50: 14-19.Google Scholar
- Clutton-Brock TH: Review lecture: mammalian mating systems. Proc Roy Soc Lond B. 1989, 236: 339-372. 10.1098/rspb.1989.0027.Google Scholar
- Heske EJ, Ostfeld RS: Sexual dimorphism in size, relative size of testes, and mating systems in North American voles. J Mamm. 1990, 71: 510-9. 10.2307/1381789.Google Scholar
- Kellogg KA, Markert JA, Stauffer JR, Kocher TD: Microsatellite variation demonstrates multiple paternity in lekking cichlid fishes from Lake Malawi, Africa. Proc Roy Soc Lond B. 1995, 260: 79-84. 10.1098/rspb.1995.0062.Google Scholar
- McKaye KR, Svata M, Stauffer JR: Bower size and male reproductive success in a cichlid fish lek. Amer Natural. 1990, 135: 597-613. 10.1086/285064.Google Scholar
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Who remembers the Six Gun Territory of yore? Head on out to Kirby's Family Farm in Williston this weekend for a trip down memory lane! Original Gunfighters, Cancan girls, Train Robberies, Indians, Live Entertainment, Crafts, Vendors and more.
Get your tickets…they are going fast! For more info check out their FB event page.
See ya there….PEW! PEW!

subset: commoncrawl


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text:
This book will change your life!
· It describes encounters with angels and demons as well as experiences with supernatural protection and communication.
· The book addresses the recent killing sprees and how the devil has launched a new campaign to use people for evil and to instill fear. Fear and faith are opposites and this book will help you expel fear and it will increase you faith.
· It provides real life "how to's" for spiritual matters. You will learn how to identify demonic oppression. The book breaks down the "nuts and bolts" of faith and explains how to obtain healing through faith in a very easy to understand fashion. It also teaches you how to increase your discernment so you can hear God's voice more clearly.
· The book touches on many vital issues including anxiety, abortion, suicide and death.
It's a powerful book that everyone should read.
Deborah Delbridge is a Christian author, speaker and business woman. Deborah's unique insight into the subconscious mind has opened up our understanding of human behavior and emotional health as well as brought us a deeper understanding of faith and victorious living. She has also achieved levels of success in the corporate world and she has pioneered her own companies in the field of real estate, mortgage, and debt settlement. She currently maintains her real estate company and is open to ministry engagements.


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Friday, April 9, 2010
Lots of Peppers, and Tomatoes
I've said before that we like to grow lots of varieties of various vegetables and peppers and tomatoes are no exception. Here are some of the little pepper and tomato plants in the greenhouse. Growing lots of varieties has its practical sides as well as well as being more fun. We can make a much nicer display at the market with various colors and shapes, hot ones, sweet ones, ones with just a little heat, thick walled for salads, thin walled for frying and drying, etc. It also means that if the weather is less than perfect, that is, the usual sort of weather, we have a lot of different responses to it in all the different varieties. It does mean that we spend a lot of time picking up the labels out of the garden in the fall. We make our labels out of white plastic yogurt and cottage cheese containers. A good way to give all that plastic a bit more time before it hits the landfill.
Posted by thousandflower at 7:11 PM
Labels: vegetables
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text:
McDonald's Kildare Town appeal axed
An Bord Pleanala has axed an appeal by fast food giant, McDonalds to build a drive-thru restaurant beside Tescos and the Kildare Village in Kildare town.
"Having regard to the distance from the traditional town centre and its isolation from existing development to the east and south-east (Tesco and Kildare Village Outlet) it is considered that the proposed development involves an uncoordinated form of development which does not integrate effectively with the existing pattern of development," they say.
And "thus failing to provide appropriate pedestrian/vehicular linkages and is therefore not in accordance with Policy R23 of the Kildare County Development Plan 2011-2017, which encourages such consolidation".
The proposed development would, therefore, seriously injure the amenities of property in the vicinity and would be contrary to the proper planning and sustainable development of the area," declared the board.
It also found that proposals "to remove trees along the road frontages, the absence of an integrated landscape approach including lack of clarity regarding roadside boundary treatment, together with an inadequate internal layout and a serious proliferation of signage at a landmark site entering Kildare Town", would seriously injure the amenities of the area and of property in the vicinity.
The board noted the concern of the inspector regarding traffic safety, however, it did not agree that this could be addressed by way of design alterations having regard to traffic levels.
McDonald's had appealed Kildare County Council's decision to turn down its application. The plans, which garnered some local opposition, were refused by the council due to concerns over increased traffic and its location at the entrance to a heritage town. The company wanted to build the restaurant along with 35 car parking spaces at the junction of the Nurney Road and the Monasterevin road.
Meanwhile, the oral hearing into the planned expansion of the nearby Kildare Village begins today, Tuesday April 30 at the Keadeen Hotel, Newbridge. It is understood the people behind the Whitewater Shopping centre sought the hearing which is being conducted by An Bord Pleanala. The Kildare Village outlet is also appealing a condition set out by Kildare County Council whereby a block within the development would require a separate planning application. The hearing is expected to last three to four days. The plans, if approved, would see the Village almost double in size. An Taisce will be entitled to attend as will Tesco who made an observation on the appeal.
- Niamh O'Donoghue


text:
The Astros put seven prospects on MLB.com's Top 100 list, while getting the highest number of "Prospect Points" in baseball, as was revealed last night. Those prospects?
Carlos Correa: #8
Mark Appel: #17
George Springer: #21
Jon Singleton: #50
Lance McCullers: #52
Mike Foltynewicz: #54
Delino DeShields: #66
It's worth noting that Jim Callis said last night that Carlos Rodon would automatically get slotted in the Top 10.
Also notable:
The Angels are the only team not to have a single prospect in the Top 100.
On the Best Tools list, the Astros have three prospects in the Honorable Mention category:
Delino DeShields: Fastest Runner
Mike Foltynewicz: Best Fastball
Carlos Correa: Strongest Arm
Friday, January 24, 2014
Astros put seven on Top 100 list
2 comments:
- mayydoubleyoo said...
any word on when the team top 20's will be out?
- January 24, 2014 at 12:58 PM
so excited to watch this team grow. not all prospects will pan out, but man do we actaully have a great, and growing farm system. carne (i misspelled crane, but i like it better as carne), WILL spend money, but only when its smart to do so. we will be as consistent as the cards...i can see it forming already...
- January 25, 2014 at 12:12 AM
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text:
At one time, when someone said "a little bird told me" they were trying to be coy. They simply meant that someone told them, but they were declining to say who. But in today's gadget laden, high tech, in touch, instant world it is much more likely they simply got a tweet on their Ipad.
Although I myself still prefer 8-track tapes & vinyl to cd's, I know that is not the prevailing view or the direction of the tide. So to that end, and to make the most of my time and my fun here in Caneyhead I now invite you to follow me.
Pick your poison...I mean pick your method. On my sidebar you can now click to follow L & F on Twitter. Or you can "Like" Caneyhead's Facebook page and stay up to date there. I invite you all to get in on it. Those who follow me here through one of these social media will not only know each time I post to this blog, but they will get tidbits that won't be found here. Let's face it, so many times there is a funny or a thought or an observation or bit of news that I'd love to share, but time won't allow for a blog post. These things I'll be sharing on Twitter & Facebook. Also, for those who actually know Caneyhead or also live in SE Texas I will be sharing info about local events, bargains I've found, places and businesses I recommend, etc. I think this works out to a win-win situation.
For those who don't play on Facebook or Twit, further down the sidebar you can still follow all the posts here at Life & Faith in Caneyhead through Blogger. If you don't have a Blogger account, no problemo...just a little further down you can get it through email with Feedblitz.
If you happen to find a post here funny, inspiring or otherwise interesting, below each post I invite you to share it by email or just about any social media you are connected to or involved in.
Let's start having fun again!