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On February 25, the Rayno Report held another one of our riveting social chats streaming live on CrowdChat and Twitter. This one was on the topic of #whitebox. With 582 views so far and a total social reach of 564,000 people, it's evident it's a popular topic!
What is a white box, you ask? These are network switches built on commodity hardware using merchant silicon, rather than the proprietary integrated systems in traditional networks. The advantage of building on commodity hardware is more flexibility in choosing your own OS and software applications — and better economies of scale.
The sponsor of the chat, Pica8 (@Pica8) pointed out that the emerging Software Defined Networking (SDN) community is building white box switches using Original Design Manufacturers (ODMs), or outsourced manufacturing outfits. This is similar to way that iPhones and servers are now built, where the hardware manufacturing is separate from software installation.
"Think of ODMs as companies that build things like iPods and servers, and they also build switches," Tweeted @Pica8. "Companies like Accton and Quanta are becoming the most well known." Pica8 provides a white box operating system based on Linux known as PicOS.
The white box movement is part of a larger open networking movement using a variety of standards to build more flexible, open, and vendor-neutral gear. As Vishal Sharma, Principal, Metanoia, piped in from LinkedIN: "… perhaps initiatives like OpenStack, and a # of open-source initiatives, which make it easier to manage disparate hardware."
Another big trend to watch in the development of white boxes is Facebook's Open Compute Project (OCP), which defines standard components for data-center hardware. OCP was mentioned several times on the chat and Pica8 supports OCP.
"I think OCP is fundamentally important, enterprise vendors are largely selling a different set of solutions to enterprises than what they sell to cloud, we need more transparency, checks/balances," tweeted in @afewell, a product specialist with Dell.
The top use cases for white boxes include Top of Rack (TOR) switches and campus switches, as well as other data applications such as big data clusters, according to @Pica8.
Prajakta Joshi (@Prajaktaplus), Director of Product, ON.Lab (ONOS), said that operators are "particularly interested in WBs for a number of reasons – extracting complexity out of dataplane, scale at reasonable cost…
"Definitely see growth driven by SDN and cloud deployments," tweeted Joshi. "As SDN takes a stronger foothold in Service Provider networks and Enterprise, I expect whiteboxes to play an important role."
The chat reflects excitement of the growth in the flexible white box model. You can see the transcript of the chat here. This was the first of a series of #whitebox chats, tune in for another in the next month or so!


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clap clap blog: we have moved
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Thursday, July 24, 2003
Jason points me to an Economist article about the rightward shift among US youth. It makes a point that may sound a wee bit familiar as regards the unintended consequences of the boomers taking over the educational system:
IN WOODY ALLEN's musical comedy, "Everyone Says I Love You", one young character suffers from a terrible affliction: compulsive conservatism. He annoys his decent (ie, liberal) parents by calling for smaller government or extolling the latest article in the NATIONAL REVIEW. Everything ends happily, however: the parents discover he is suffering from a brain tumour. The tumour is removed, and with it goes the youth's annoying politics.
These days more and more young Americans are suffering from a similar affliction. This week Washington saw two jamborees for young right-wingers: a National Conservative Student Conference, put on by the Young America's Foundation, and a National Convention of College Republicans. Hundreds of young conservatives flooded into the capital to listen to their heroes (including a wrestler called Warrior), to learn how to identify liberal textbook bias, to visit the White House, and to watch Karl Rove receiving the Lee Atwater Leadership Award.
Why this upturn in conservatism? One reason is a healthy desire to tweak the noses of people in authority. America's academic establishment is so solidly liberal that Naderites easily outnumber Republicans. The leftists who seized control of the universities in the 1960s have imposed their world-view on the young with awesome enthusiasm, bowdlerising text-books of anything that might be considered sexist or racist, imposing draconian speech codes and inventing pseudo-subjects such as women's studies. What better way of revolting against such illiberal claptrap than emulating the character in Mr Allen's film?
By going to the moderate left, of cou....oh wait, that doesn't exist because all the leftists my age are friggin' crazy.
Well, maybe I'm just feeling bitter, but it does seem like taking a moderate oppositional stance against the identity-politics loonies would be a bit more effective than right-wing pranksterism. But maybe it's just that you can't oppose the loonies because they're so good at shouting you down (anyone who's tried to take a slightly oppositional stance on a campus recently knows this) so ineffective rebellion is the best option. I don't really believe that, though.

subset: commoncrawl


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I like the way they bring out the best in their students. I like being able to teach as opposed to just being a traffic cop. I abhor monopolies and relish competition. Private schools offer competition and an alternative to public education. Let's not lose sight of that basic fact. The egalitarian and other social issues serve merely as a smoke screen to obscure what is wrong with public education in America.Good stuff. Sure, there are some things about independent schools which aren't pretty, but that could also be said about public schools. The bottom line: if I want to dedicate my life to teaching and working in schools, I want to do it in an environment where I can make a difference, where I can feel save, where I can develop deep and meaningful relationships with everyone in the community, where the values of the institution are aligned with my own values and where we actually strive to live those values, and where mediocrity isn't tolerated but meritocracy is demanded.
Thursday, December 21, 2006
Why independent schools?
Recently, a few of my friends and colleagues have asked me why I'm looking to teach in a boarding school. I have a variety of reasons, some of which I discuss here. Then, today, I saw this bit from Robert Kennedy who writes the About.com site for private schools. Here he's talking about independent schools and his love for them:
Posted by Peter A. Stinson on 12/21/2006
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Joaquin Tintoré Subirana
- Director
- Phone number: +34 971439821
- Fax: +34 971439979
- E-mail: jtintore at socib.es
Joaquin Tintoré Subirana
About me
Ph. D. Physics – Physical Oceanographer
ICTS SOCIB, http://www.socib.es
Dr. Joaquín Tintoré is Professor of physical oceanography from CSIC at IMEDEA (CSIC-UIB) and since December 2008, Director of the Spanish Large Scale Marine Infrastructure, SOCIB (Balearic Islands Coastal Ocean Observing and Forecasting System), a new multi-platform facility of facilities that responds to scientific, technological and strategic society priorities related to the role of the oceans and the coasts in a global change framework.
Throughout his career he has studied the physical processes and mechanisms that can explain the dynamics of the coastal ocean and its multidisciplinary interactions (from the nearshore to the open ocean) with particular emphasis on the impacts of fronts and instabilities such as mesoscale and submesoscale eddies on upper ocean vertical biogeochemical exchanges. He has always combined a threefold approach: (a) searching for new and non-repetitive scientific ideas, (b) maintaining high quality excellent science linked to technology development and (c) developing new tools for decision support and by this increasing the transfer of knowledge to society and contributing to science and ecosystem based Integrated Coastal and Ocean Management (ICOM).
He has published 139 papers in international refereed journals, has been principal investigator in 47 peer reviewed research projects and has also coordinated two EU funded international projects. He has been the advisor for 9 Ph. D Thesis and 10 MSc Thesis. In 2003 he obtained the Spanish National Research Award for his "outstanding research contributions in the field of coastal oceanography and mesoscale dynamics".
With respect to some of his experience in Management of science, he was Scientific Manager of the first Spanish Marine Sciences and Technology Programme (1995-1998) and Vice-Chairman from the Marine Board of the European Science Foundation (1997-1998; member 95-98). He was Director from IMEDEA (CSIC-UIB) from 1999 to 2008 and Executive Scientific Coordinator from Marine and Environmental research activities at CSIC involving 21 research institutes in Spain and over 1.700 research personnel (2001-2004). He served in the Prestige Scientific Advisory Committee (CCA) in 2002-2003, as well as in many other international committees and boards.
His present interest includes the implementation of new monitoring devices such as autonomous underwater gliders (more than 15.000 profiles since 2006) by this contributing to a paradigm change in ocean observation: from single platform ship based observations to multi-platform integrated and distributed observing and forecasting systems (the basis for new international observatories and of the large scale installation SOCIB).
SOCIB reaches in 2014 its operational phase, therefore contributing to peer review state of the art science, the development of new technologies and also the development of tools for science based decision support, by this, increasing our capacity for knowledge based, reliable and independent response to society needs.
Publications record:
139 publications in peer review journals.
- H index: 33 (H=22 for the last 5 years; citations 3498 (1650; last 5 years). Source: Google Scholar citations 12/2013: http://scholar.google.es/


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GB Locking Systems Ltd was formed in 2003 and has been established as a Company specialising in the specification and supply of access control and door automation products to the trade. We have a combined total of over 60 years experience in the industry and have a vast knowledge of electronic locks.
We stock products only from reputable sources such as CDVI, Videx and Waferlock amongst others.
Our vast knowledge of access control and electronic locks means you can be sure that we will only specify and supply products that we know will work according to requirements.
We are constantly working to improve and expand our range of quality products and have included several new additions in our latest catalogue.
GB Locking Systems have gained an outstanding reputation for customer service, and take a great deal of pride in providing all customers with great service on a personal level.
We offer a full service support package, including technical support, site surveys, and project management.
We are able to offer expert assistance, either by telephone or by visiting a site directly, to specify the most appropriate system and to ensure each customer's individual requirements are met.
We also offer training and technical assistance along with technical drawings and wiring schematics – all of which are tailored to application.


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Statement by Nick Tomkin
Long-term strategies have a habit of losing momentum and excitement, so it is easy to see why many might not understand the benefits of LRT today. In 10 years from now, do we want to say we should have? Hamilton deserves forethought on this magnitude.
Join Nick Tomkin and 10987 others:
Show your support for LRT
Please note: Statements will be sent to the contact list which includes City Council, MPPs, Premier Wynne, and local provincial candidates. These politicians and officials may respond to you via email.


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Bride Seats
Bride seats concentrate on safety to enhance their sports seats to perform better. Every sport seat goes through various crash tests to conform with the safety standards of Japanese circuit racing: F.I.A.official homologation.
The number of race car drivers using Bride Super Seats has continually increased. With every driver's victory from different classes and categories, feedback is given by the drivers themselves. Feedback is a vital information source that Bride has taken in to consideration for enhancing and developing a better and safer super seat.
Bride bucket seats: These are fixed back bucket seats made to provide support for fast road and track use.
Bride reclining sport seats: These are fully reclining sport seats made to replace your existing car seats with a sporty look and design.


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Monday, 30 September 2013
Messy Play with Persil NZ - (A Sponsored Post)
I love doing crafts and messy play with my kids, but I have to confess that sometimes I get caught up thinking about the 'mess' rather than the fun and my boring adult-ness seems to come through.
Although I try and teach my kids to look after their things, I don't want them to be materialistic. I'd rather them value people and memories over things any day.
So I want them to learn by experience, touching and being creative – and perhaps it wouldn't hurt me to forget my stuffy adult-ness and get down and get involved too. To feel the squelch of mud between my toes and do a finger painting. One of my favourite memories as a kid was playing 'ewwy gooey' in the backyard – basically Mum would give us whatever old ingredients she had in the cupboard and we would make crazy concoctions. Such fun!
So, when I was given this opportunity to work with Persil on this campaign, I was initially disappointed that they didn't send me an All Black; but instead I decided to take a look back at some of the messy and creative memories I've helped create with my kids.
Is it just me or does mess seem to be proportionate to fun for kids?
The great thing about having a good washing powder/ detergent like Persil, the only permanent reminders will be in the photos not on the clothes.
What's your favourite messy/fun activity?
Jen x
This is a sponsored post but opinions are my own.
Sunday, 29 September 2013
Selfish Sewing (Sweet Scalloped Shorts finished!)
I have finally finished my Sweet Scalloped Shorts that I've been making for selfish sewing week. I really enjoyed this project. It was a bit of a stretch for my sewing skills, but I felt like I wanted to learn new skills so it was a good challenge.
As I mentioned in a previous post I had a wee bit of a battle with the welt pockets – mainly with attaching the pocket bags; but now I feel confident doing them in a future project. I also did darts (I've only done them once before) and my first ever invisible zip.
Now I'm looking forward to making a couple more pairs in different colours to wear this Summer.
The pattern is sweet scalloped shorts from Pattern Runway and I used cream linen fabric.
During Selfish Sewing Week I also made a knit maxi skirt (which I haven't yet had a chance to photograph properly) and have partially made another Wiksten tank, although I'm not so sure if the colours suit me – I might have to give it to someone else.
Jen x
Joining in with Selfish Sewing Week organised by Rachael from Imagine Gnats and Jill from Made with Moxie. …(And Show and Tell, Made by Hand, and Make it wear it and Wardrobe Wednesday and WIWW, later in the week.)
Saturday, 28 September 2013
"A portrait of my children, once a week, every week, in 2013."
Noah, Isabelle and Pipi: We visited a local waterfall today, the kids had a lot of fun and all 3 fell asleep in the car on the way home. My favourite photo is this one of Isabelle – this pose is so typical of her.
Jen x
Joining in over here
To see more of my weekly portraits go here.
Wednesday, 25 September 2013
Selfish Sewing (Days 2 & 3 snippets)
Continuing on my sewing for selfish sewing week, yesterday I spent a long time battling with the welt pockets on my sweet scalloped shorts. Mainly I was just battling to understand the instructions. I worked out how to do the welt but attaching the pocket bag had me stumped. I googled it and it seemed I was in good company, a bunch of other people had had the same problem. In the end I worked out a solution that works ok.
Because of the frustration that came from the welt pockets I really wanted a really simple and easy project to lift my mood. So, today, as well as plodding on with the shorts I made a simple knit maxi skirt using this awesome tutorial. It was terrible weather here today, perfect for being inside sewing – but not so great for photos! Oh well, I said I only going to post sneak peeks until the end of the week anyway…
And here's my little sewing buddy who kept rolling onto and dribbling on my fabric…
Jen x
Joining in with Selfish Sewing Week organised by Rachael from Imagine Gnats and Jill from Made with Moxie.
Monday, 23 September 2013
Selfish Sewing (Day 1 & some inspiration)
Hello! Did you do any sewing for YOURSELF today?
Well, as I mentioned in this post I'm taking part in Selfish Sewing Week organised by Rachael from Imagine Gnats and Jill from Made with Moxie.
So what have you sewed yourself today, you might ask? Well, uh … nothing (yet). BUT I have done a lot of preparing to sew.
I don't know about you but I prepare to sew 1 of 2 ways. The first way I run around and do all the housework first so I don't feel guilty about sewing (also it helps if you want to lay fabric/ patterns out to have a clean floor); or secondly, I say stuff the housework, I'm sewing!
Today was a scenario 1 kind of day (I had planned on doing this all in the weekend but sickness and visiting family meant that didn't happen.) This is how my day played out:
- Watch America's Cup races while nervously and speedily folding the washing (I tell you, it saved my nails a bit too, keeping my hands busy like that! Go Team NZ!)
- Get a casserole bubbling away in the slow cooker that will last at 2 nights (freeing me up to SEW!)
- Dishes, vacuum etc
Then I pre-washed, and cut out these sweet scalloped shorts
I'm happy taking things slow because I'm really trying to do things properly; and it seems to be my natural tendency to sometimes rush projects just to get them finished quickly.
I plan to do a few sneaky peeks during the week, and then fill you in with what I've made with a big reveal at the end… Just to be a bit elusive (and also by my grown up photo taker is away working for most of the week.)
So for now, here is a bit more selfish sewing inspiration that I've just stumbled upon via Pinterest/ other blogs etc in the last couple of days – unfortunately I don't all the fabric at hand to make these things, but trust me I'll be trying them soon enough!
I just found Nette's version of the Blair batwing shirt and I LOVE it. The polka dots are perfect. (Probably a post selfish sewing week project for me though.)
I just discovered this one today, via Imagine Gnats; an Etsy tutorial on how to design and sew your own leggings – AWESOME! (Again this is not something I'll make this week though – need to buy some cotton, lycra blend fabric first.)
Free 'Kimono cool' tutorial from Elle Apparel – isn't it (and she) gorgeous?
What have you been sewing/ getting inspired by recently?
Jen x
Sunday, 22 September 2013
"A portrait of my children, once a week, every week, in 2013."
Noah: drawing a sun
Isabelle: Really enjoying her fluffy at a local carnival (photo credit to Auntie Lecy)
Pipi: tummy time!
Jen x
Joining in over here
To see more of my weekly portraits go here.
Friday, 20 September 2013
'Round here
It seems I've been doing so many craft and review posts that I've hardly had a chance to say "Hello!"
Don't get me wrong I love showing you what I've been making and sharing cool products with you but I know the real reason you read my blog is to listen to me and ramble on about all the mundane details of my life, right? So I thought it was about time I filled you in on the haps around here:
In bullets (as inspired by Stella and Ange):
- It's been a bit of a sick house round here. For the last 2 weeks my husband's had the man flu and had it bad! And for most of this week Noah and Isabelle have had conjunctivitis. This has made me realise 2 things – 1) How grateful I am that I had the flu jab while pregnant with Pipi (giving the both of us immunity); 2) That it is extremely difficult to get eye drops in little kids' eyes.
- We're in the throws of toilet training (Isabelle that is) – she showed some consistent early success, but there's been more misses than hits these last couple of days (perhaps this is due to being a bit unwell.)
- Noah wrote his own name – well it was more of a 'Noab' – see photo below. I painted each letter with water and a paint brush and he traced it with chalk, but it really boosted his confidence.
- My 3 favourite TV programs at the moment are: Call the Midwife, America's Cup footage and the Block NZ – not necessarily in that order. Such a weird collection of shows.
- We saw our Plunket nurse the other day and she remarked at how strong Pipi is – she's forever trying to pull herself up into sitting position. I know they always say these sort of things to encourage Mums, but my heart swelled with pride.
- I can't stop making and eating this stuff – I think my 'food baby' will start 'showing' soon.
- My in-laws, Mum and her husband and Dad and my step Mum all pitched in and bought our kids a super duper awesome trampoline for Christmas, taking advantage of a great special. It arrived in boxes today and is safely hidden in the garage. Now to keep it that way 'til Christmas.
- Stella has a really awesome giveaway on her blog at the moment – go check it out! Although I realllly want to win!
And now for some photos by Noah. (He runs off with my camera any chance he gets!) …
What is happening at your house?
Wednesday, 18 September 2013
{Sewing for ME} Contrast Shoulder Slouch Tee
[Please excuse all the 'headless' photos – all of the photos of me wearing my new handmade top are either selfies by me to show the shoulder detail or have been taken by Noah aged 4. But, hey he's getting better!]
I've been feeling the urge to sew for myself a lot recently. Previously I've made a few Wiksten tanks, a merino circle top and a purple merino wrap dress (made in my pre-blogging days). I get a lot of wear out of all of these garments.
I would love to be able to make a few more items to bulk out my Summer wardrobe. I get frustrated sometimes shopping for clothes when I have an idea of what I want in my head but just can't seem to find it on the shelves. Plus it helps to save me money and I get to learn some more skills along the way, all the while enjoying my hobby – seems like a win, win really! This has coincided with the added inspiration of some of my other blogging friends doing the same thing and Selfish Sewing Week being next week.
So, why sew something now when Selfish Sewing Week is next week? It's simple really, I saw this tutorial on iCandy handmade and wanted to make it NOW! So I did. It was a really simple sew. I used a really thin (tissue) knit I had in my stash of the main part and some cream silk scraps for the contrasting shoulder details. As I usually wear a smaller size than that provided in the free pattern I drafted my own off a top I already own which is a similar style – however, if I make another I definitely will make it longer.
And my plans for Selfish Sewing Week?
My main goal is to do a bit of sewing on these sweet scalloped shorts. These are definitely a bit of a challenge for my skill level, but I'm looking forward to the challenge. I don't think I'll get them finished in the week, I don't want to rush them after all – but I want to make a decent start. I've got some lovely cream linen to use for these.
And to give me a bit of satisfaction that comes from finishing a project or two (while I have that slow burn project in the background), I also plan to sew another Wiksten tank and perhaps another top like the one above or a maxi skirt. We'll see – I'm aiming for fun, not stress after all!
I have quite a few other projects planned to bulk out my Summer wardrobe, but I'll get round to them sometime, just probably not next week! … Perhaps I'll share some of these ideas in a later blog post?
Are you sewing anything for yourself at the moment? Got any cool patterns/ tutorials to share with me? I'd love to hear from you!
(And although you can't see much of the top here, here's some proof that I indeed do have a head, and a cute baby and massive bags under my eyes, ugh!)
Jen x
Joining in with Show and Tell, Made by Hand, and Make it wear it.
Tuesday, 17 September 2013
Breastmates Nourish Maternity Nursing Top Review
Recently I was very lucky to be sent this gorgeous Nourish Maternity Nursing Top from Breastmates to review. When it arrived the first thing that struck me about it was the super softness of the fabric and the great quality of the workmanship (being someone who sews a lot this is something that I tend to notice and value.)
I have to confess that apart from a few breastfeeding singlets, previously I haven't really been the biggest purchaser of breastfeeding clothes. But then again, prior to Pipi I'd only had Summer babies; and this time around I was finding it a bit chilly lifting up my top to feed on those cold Winter mornings. Also, it's quite nice not to have to display your post-baby tummy, especially in those first few weeks. With the Nourish Maternity Nursing Top, you don't have to due to "easy access breastfeeding openings are via an inner vertical slit hidden behind the pleats."
The pleat design is awesome for a few different reasons:
- To enable discrete breastfeeding as mentioned above
- It's very flattering, especially how it skims over any post baby 'wobbly bits'
- Is designed to be worn during pregnancy also, and the pleats expand over your growing bump.
- And beyond all of these practical reasons, it's just a beautiful classic style – 'Grecian' is the word that springs to mind for me. It just drapes beautifully.
Being something you can wear both when pregnant, then breastfeeding (and beyond) means the Nourish Maternity Nursing Top is extremely versatile and great value for money. If you're a long time reader of my blog then you'll know I don't think people need to spend masses of money when pregnant or with a new baby, but instead we should use what we have, recycle (mend & make new) and then when we need to, buy quality products that last and last. In my opinion, this, and the other Breastmates' products fit this bill.
I know I'll be getting a lot more wear out of this top, that's for sure! Thanks to Franny from Breastmates for sending it to me to review.
Have you checked out Breastmates before? I also have my eye on their clip on camis – such a genius idea!
You can also find Breastmates here on Facebook.
Jenny x
(Joining in, for the first time in ages with Wardrobe Wednesday and WIWW.)
Monday, 16 September 2013
DIY Chalk Cloth Bunting (No sewing machine required)
I'm extremely happy with how this project turned out – first of all, it's super quick and easy (no sewing machine required) and was something that I could make with my pre-schoolers. Ok – so Isabelle just amused herself by drawing on the bunting, but Noah did most of the threading for me and an older child could probably manage the whole project themself.
Secondly, it looks awesome (more than my less than average photos show) and will be SO USEFUL in that I can simply rub out the chalk and make a sign say whatever I want for any occasion or celebration. We are only limited by the colours of chalk we own and our imaginations – 'Happy Birthday', 'Merry Christmas' – whatever.
Have you used chalk cloth before? This is my first time. I actually bought my chalk cloth from Spotlight for a completely different project (which I still plan to do), but then this one just kind of happened. Chalk cloth is a flexible, non-fray vinyl that can be cured* to be used as a chalkboard.
I made by bunting 5x5 inches (I usually use metric but just happened to have my quilting ruler handy at the time.) I wanted to make them even width and height so as to use the fabric most economically. I marked my template with chalk and cut them out with sewing scissors. I managed to get 17 triangles across the width of the fabric (I'd bought only a 1/4 metre and still have around a half of this left.)
Because it doesn't fray you don't have to worry about hemming! Bonus!
I used a needle to puncture a hole in each of the top two corners of each triangle and I hadn't them to Noah to thread with string with a large, blunt (kid-friendly) wool needle. I helped him a bit with this. Because the cloth had been rolled up I choose to thread it the way I did to straighten it out.
Then we cured (*this is the process by which you rub chalk all over the cloth. Clean. Then repeat the process again.) ; and wrote letters on our flags.
And then we were done! Ta da!
We've been really getting into The America's Cup – so I thought it only fitting for the first use of our flags to be a banner in support of our team. Go Team NZ!
Noah, you know you're not allowed up on the couch like that!
All in all, it was a fun, easy and super effective craft that I was able to do with the kids and something I know we'll get a lot of use out of in the future.
What have you made with chalk cloth? This is definitely not the last you'll see of it on this blog!
See here for other craft projects to make with kids
Jen x
Joining in with the lovely Miriam


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Set Up
Today is set up day for the AMAZE ME installation at Dover Street Market in London. As with everything that comes flat packed, assembly is never as strightforward as the instructions make out – and this doesn't have instructions. The four week installation will officially begin on Monday, but if you visit the store tomorrow you'll see it being tested.


text: Blog Home - Previous Post | Next Post How To Remove A Carpet Stain Posted on Jul 29, 2016 5:31pm PDT Keeping your carpet free of stains is an admirable goal, but one that may require a fair bit of work if you want to be successful. When you inevitably find a stain, your first step should be to determine just what caused it. Did your kids run wild and attempt to reenact the Battle of Bunker Hill with their dinner? Did you place your morning coffee just close enough to the edge of the table for gravity to take over? Did your pets ignore all warnings to keep the mud and dead critters outside? No matter how terrible a stain may look, there's always a way to fight back. Removing Pet Stains Pick up what you can. If your pet brought home a little present for you, you're going to want to put on a pair of gloves first so you can pick up whatever they dropped off and throw it in the trash. If they left behind a wet spot, grab a towel and dab at the mess until it's reasonably dry; make sure you don't smear or rub it in though. If the spot is already dry, grab a spray bottle and get it a little moist. Once you've done that, apply a stain cleaning product to the area. One of the best ways to deal with any smell is to mix a quarter of a cup of white vinegar with a quart of warm water and use a spray bottle to spritz the solution on the stain. Let it sit for a few minutes before grabbing a towel to dab it dry. If these techniques fail, you can also mix a quart of water with some stain removing laundry detergent in a spray bottle, spritz your solution on the stain, and let it sit for a few minutes. After waiting for that little bit, dab it clean with a towel, and if necessary, repeat the process until the stain is gone. Removing Coffee Stains The sooner you act, the more effective your efforts will be. First off, grab a few towels to dab the spot dry; only dab, never, ever smear or rub. Switch to a clean towel if your first one becomes too dirty. Mix a quarter cup of white vinegar, a quart of water, and a bit of non-bleach detergent in a spray bottle and spritz it over the stain. Let it sit, rinse it off, and repeat as necessary. Pick up some carpet cleaner from the store and follow the directions on the bottle. Before you attempt a full-blown clean, be sure that your carpet can safely handle the cleaner you're intending to use, and for safety's sake wear a pair of gloves to protect your skin from potential harm. Removing Blood Stains Again, the sooner you act, the more effective your efforts will be. Once you've made sure that the person responsible for the blood has received the necessary medical care, make sure you're only using cold water to clean the stain; blood coagulates with heat, while cold will help protect your carpet fibers. Fill a spray bottle with cold water and two tablespoons of grease-fighting liquid dish detergent. Completely soak the stain with the mixture, then dab the stain with a towel. Rinse with cold water and repeat as necessary. Bleach free stain removers like OxiClean are great for removing blood stains from almost any material. While the directions may recommend using warm water, cold water should work just fine in this case. Apply the mixture to the stain, dab at the wet spot with a towel, rinse, and repeat as necessary. No one wants a carpet covered in stains, but sometimes a home remedy might not be enough. In those cases, call The Maids at (972) 471-9509, or visit our website for a free price estimate. Since we were founded in 1979, The Maids has been one of the leading home cleaning services across the United States and Canada. With locations in more than 90 cities in North America, the clean home you've always wanted is just a phone call away. Related Posts: Top 6 Reasons People Hire a Cleaning Service 5 Tips To Help You Vacuum Categories: Tips, House Cleaning Permalink


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Twenty Fourteen – Sidebar, header and search box
Hi All.
I have set up a wordpress blog which I plan to display on another webpage using and iframe. The idea being end users can update contents on a news feed without me having to add everything for them.
The page can be viewed here: http://www.cccfr.org/cms/
I am using the Twenty Fourteen theme and so far I have managed to clear much of the content through the settings but I need to remove the search function at the top, change the main body background to #D8D8D8 and change the sidebar and page nav bar to from #FFFFF to #D8D8D8
Also, I need to remove the data and time stamp form the posts,
Any advise gratefully received.
- The topic 'Twenty Fourteen – Sidebar, header and search box' is closed to new replies.


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Little Mix want rapper on new album
- Bang Showbiz
- 14 October 2016
Little Mix's Jesy Nelson says the band are in talks to get a rapper to feature on their eagerly-anticipated fourth album, 'Glory Days'
Little Mix have teased their plans to get a rapper on their new LP 'Glory Days'.
The girl group - who won 'The X Factor' in 2011 under the guise of mentor Tulisa Contostavlos - will release their fourth album on November 18 and singer Jesy Nelson has spoken of plans to have someone spit lyrics on one of their tracks.
She said: "It would be great to get a rapper on the record, we'd love to have one feature, we can't say who we have in mind just yet."
The 'Black Magic' hitmakers - also comprised of Perrie Edwards, Jade Thirlwall and Leigh-Anne Pinnock - released lead single 'Shout Out To My Ex' earlier this week, which is reportedly aimed at band member Perrie Edward's former fiancé Zayn Malik, who left the pop beauty devastated last year when he called off their engagement, and she has hit back in the band's forthcoming single 'Shout Out To My Ex' which is said to mock his sexual prowess.
On the track, she sings: "I hope she gettin' better sex, Hope she ain't fakin' it like I did, babe."
Perrie, 23, says it is the "perfect" lead single" and shows what fans can expect from their new album.
She told the Daily Star newspaper: "We're really proud and excited about our new album and can't wait to share our music with everyone.
"Shout Out To My Ex' was unanimously our favourite choice for the first single. It's the perfect taster for what is to come!"


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Our fourth and, Lord willing, final baby, Lewis Will-Edmond, has arrived! And he's settling into our home quite perfectly. It may be too early to tell, but it doesn't seem that his four names add up to a large personality. Our little guy is calm and cool… well, until he wants milk, and then he starts making a snorting noise that could call a farmer's pigs home. You might think this call of the wild would send the kids running away, but on the contrary, it's just one more thing that has all five of us falling more in love with our little piglet.
Before Lewis was born, Sarah and I often talked about what kind of brother Bowen would be. It has been such a joy to see how loving and sweet he is to Lewis. We were afraid he might become confused or jealous over all the attention his little brother would be getting, but he's just joining in. He loves to help by bringing Sarah diapers and wipes when it's time to change him, and even taking dirty ones to the trash. He loves to rub his head and give him kisses, and has clearly decided that it's his duty to make sure Lewis has his pacifier at all times. I guess that makes him the paci patrolman. Bowen may have a little heart, but you'd never know it by the way he loves.
Sarah, the day after Lewis was born.
Moments after delivery.
The first time they met.
Bowen, sharing his toys.
Digging Deeper: Lord Willing
"…You do not know what tomorrow will bring. What is your life? For you are a mist that appears for a little time and then vanishes. Instead you ought to say, 'If the Lord wills, we will live and do this or that.'" James 4:14-15
Over the past couple of years, I've found myself regularly using the phrase "Lord willing" before expressing my own plans, desires and intentions to others… especially since we found out Bowen had HLHS. That news put a wrench in our "perfect" plans and dreams, but through it we learned to trust that God had something different, dare I say better, in mind. Surrendering to the fact that all of our plans are subject to interference and failure has been a key to finding contentment through our struggles.
Maybe you're questioning whether it's God plans or your own that you are living out at the moment. If it's your desire to serve the Lord and to commit your life to him, just rest in the assurance that He's working "all things," including your questions, doubts, screw-ups, worries, bad days and disaster bound ideas for a bigger and better purpose than you can see right now. Don't lose your faith.
The plans of the heart belong to man, but the answer of the tongue is from the Lord.
All the ways of a man are pure in his own eyes, but the Lord weighs the spirit.
Commit your work to the Lord, and your plans will be established.
Proverbs 16:1-3


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The Lam Dong provincial People's Committee has decided to reschedule the Da Lat Flower Festival from 2009 to 2010 to coordinate with the 1000th anniversary of Thang Long - Hanoi. The event, previously scheduled for December 19-23, 2009, will be held from January 1-4, 2010.
It will be the country's first major event of 2010, kicking off a lineup of cultural activities to celebrate the 1000th anniversary of Thang Long-Hanoi.
Preparations for the event have been virtually completed, with a general programme, opening and closing scripts and a budget already approved.
All rights reserved© 2012 Vietnamtravelresort.com. Registered in UK. Business License: 08061654 Address: THE MERIDIAN, 4 COPTHALL HOUSE, STATION SQUARE, COVENTRY, WEST MIDLANDS, ENGLAND, CV1 2FL Tel: +44 (0) 843-532-55-12; Email: email@example.com Website: www.controlandmanagement.co.uk


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Harrowby United are undone by single goal from high-flying Rangers
United Counties League
Premier Division
Harrowby United 0
Deeping Rangers 1
Harrowby United welcomed in-form Deeping Rangers to Dickens Road on a sunny but chilly afternoon for a Boxing Day Lincolnshire derby.
Rangers started the game having put together an impressive 18-match unbeaten run that sees them sitting third in the league table.
It looked like the game would go with the form book early on as Rangers started brightly, putting the Arrows under pressure from the off. Harrowby custodian Joe Christopher saved from Rangers top scorer Scott Coupland after 10 minutes, the striker's weak left foot effort comfortable for the keeper to get down to.
Three minutes later, Coupland again had a shooting opportunity but blazed his effort high and wide of the goal after Arrows debutant Callum Barratt was been dispossessed in midfield.
Harrowby created their first chance in the 18th minute when a corner was knocked down in the Rangers penalty area, falling to Liam Jaques who stuck out a leg but could only stab the ball wide. Three minutes later, from another corner, Jack Stafford had a shot blocked and the rebound effort from Jaques again went wide.
On 22 minutes, a poor defensive clearance by Harrowby dropped for Coupland who was this time denied by a fine block tackle from Arrows skipper John Currall.
The game's solitary goal came on the half hour mark when more sloppy defensive play led to a poor clearance kick from Christopher which was gathered by Rangers Jason Kilbride. The wide man advanced down the right flank before delivering an inch perfect cross for an unmarked Coupland to nod down and into the corner of the net from 10 yards out, to score for an impressive sixth game in succession.
Harrowby again gave the ball away cheaply in a dangerous area in the 35th minute but this time Currall dealt well under pressure with Kilbride's low cross.
Five minutes before the break, a good move down the left between Harrowby's Luke Johnson and Scott Floyd ended with the latter playing a teasing ball across the six yard box for Luke Peberdy, whose shot was well blocked by Rangers centre back Luke Hunnings.
The second half started with Harrowby having their best offensive period of the game, creating pressure as they kept possession better and pushed Rangers on to back foot.
Stafford headed a corner from the right just over the crossbar before the hour mark. Three minutes later, Harrowby were awarded a free kick 20 yards from goal and Matt Clarke stepped up to fire a low shot around the Rangers defensive wall, but Rangers keeper Richard Stainsby produced the save of the game to turn the ball around the post.
This was to prove to be Harrowby's closest attempt on goal as Rangers came alive and looked a real threat on the break.
A 66th minute free kick from Dan Schiavi almost doubled their lead as his strike from 25 yards dipped late and hit the top of the bar. Another break four minutes later, produced a cross from the right which was headed on to the post by Rangers substitute Will Bird.
As the game entered its closing stages, Harrowby lost a bit of discipline as Rangers attempted to run down the clock. Sam Weatherstone hacked down Rangers forward Scott Mooney to receive a yellow card before, in stoppage time, receiving a second yellow and ultimate red for a rant at the referee.
Rangers saw the game out to extend their unbeaten run to 19 games.
Jaques also saw red after the final whistle as he voiced his displeasure a little too vehemently at referee Mr Bright
Harrowby United: Christopher, Weatherstone, Johnson, Currall (c), Stafford, Kembertiz, Jaques, Barratt (Matongo 17), Floyd, Peberdy, Clarke. Subs not used: Hanratty, Brettoner, Bennett (GK).
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Finally, an information leak we can all be proud of. It's the 2008 Subaru Impreza WRX in the buff, courtesy of our commendatori at Autoblog.it. Out with the chrome-y grill, and in with a more tasteful gunmetal look. Still, that profile is as ungainly as a hippo wearing one of Wink Martindale's Botany 500 suits.
Nuova Subaru Impreza - foto reali, finalmente [Autoblog.it]
The 2008 Subaru Impreza: Real? Fake? Photoshopped? Yes. [internal]


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Dr. Phoebe Chow
We offer many unique testings and treatments to address the root causes of various illnesses in order to achieve a cure and an optimum level of health instead of just managing symptoms.
We are one of the first few naturopathic clinics that provide ozone therapy in Vancouver. We specialize in many intravenous therapies such as chelation, hydrogen peroxide, careseng, glutathione, alpha lipoic acid, various vitamins/minerals/amino acid, placenta and homeopathic preparations.
Dr. Phoebe Chow is a licensed naturopathic doctor who has been in practice in Vancouver, BC since 1989. She obtained her B.Sc Honor degree in human physiology from the University of British Columbia and a B.A. degree in business administration from Simon Fraser University before entering into a four-year post graduate study in naturopathic medicine.
She has received further training and is certified by The College of Naturopathic Physicians of BC in ozone therapy, prolozone pain treatment, acupuncture and chelation. Dr. Chow is also licensed to prescribe most pharmaceuticals such as bio-identical hormones.
With her experience in oxidative therapies and anti-aging medicine, she has written articles on ozone therapy which are published in Alive magazine (Oct, 1995 issue), the "Encyclopedia of Natural Healing" in 1997 and Vista magazine (36th issue) on "stem cell and anti-aging". A recent article on "Treasures right from your own blood" was also published in the October, 2010 issue of Explore magazine and platelet-rich-plasma therapy in Health Action magazine, the winter 2011 issue. She was also interviewed twice on a regional TV station, Fairchild TV, in Vancouver.
With over 20 years of clinical experience, Dr. Chow and her well trained team have treated many clients both local and abroad with good results in many conditions ranging from colds/flu, allergies and anti-aging to more serious illnesses such as cardiovascular disease, autoimmune conditions and cancer.


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This is the last item I included in my Harry Potter swap. I was least impressed with this one. My partner had wisted some wool dread falls that were really nice looking, but having no wool available, I found a tutorial on making acrylic dreads. Lets just say, it really takes a lot of time to make these. And, I'm not really sure if my partner will actually even wear them. :)
These dread falls are made from acrylic yarn that has been brushed and mamed into dreads. You have to boil the dreads to get them to hold together. I experimented with many different things while making them. There aren't enough of the ones I made to really create the look. So, she will have to finish making more, herself. Hehe.
I might eventually make my daughter some or make some for a future costume.
35 minutes ago


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This is our ever-changing collection of quotations, from both the famous and the obscure. Words of wisdom and stupidity, of wonder and fear, of admiration and execration, of hilarity and despair. Just for fun.
"Words strain,
Crack and sometimes break, under the burden,
Under the tension, slip, slide, perish,
Decay with imprecision, will not stay in place,
Will not stay still."
T.S. Eliot
Quotation of the week
"The best advertisement for free expression is the use of it. We have a moral obligation to speak of difficult topics, and to speak for people in countries where such open speech is perilous. We demonstrate our support for free expression when we refuse to let the Chinese censor a book we are publishing in the People's Republic; when we write openly about the complexities of Islam and refuse to be bullied into silence; when we push and push to find out the truth about the prisoners held in Guantanamo; when we insist that writing can be a moral act."
Andrew Solomon, President of PEN
More words of wisdom...


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Cornell researchers see algae byproduct as prime animal feed
Biofuels Digest
This blog is produced by the Center for Advanced BioEnergy Research CABER) at the University of Illinois. CABER is under the direction of Hans P. Blaschek, professor and Assistant Dean of the U of I College of Agricultural,Consumer and Environmental Sciences Office of Research. This blog is a roundup of research news and related topics dealing with biofuels. It does not cover biofuel production and prices at this time.
Biofuels Digest
Meghan Sapp | May 27, 2014
Read more
Posted by Natalie at 2:00 AM
Labels: algae, biodiesel, Cornell University, livestock


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Jazz critic Ben Ratliff gave my new CD, The Art of the Soprano, Vol. 1, a great review in today's New York Times, Arts & Leisure section.
It was nice that he was able to trace the arc of growth between the three solo CDs: Monk Abstractions (2007), Blue Soliloquy (2010) and The Art of the Soprano, Vol. 1 (2012). And let me just say that this is one of the benefits of being a do-it-yourself artist. No label will just sit back and patiently let you work out your thing, over the course of five years, while you make three solo soprano saxophone recordings. And understandably so. Art and commerce don't mix. Sort of like oil and water.
What's really interesting, is that I almost didn't release it. Like with most recordings, after I made this one, I went through Post-Recording-Depression (PRD). This is where after you record it, you think, "Wow, this is a great CD!" Then three-months later, you're wondering how you could have allowed such a tragedy to take place. You start to focus on that one note that was out of tune, that one phrase played slightly out of time, that extra chorus of rambling, that second take, which may have been the better of the two, and the list goes on and on.
At one point I even told myself--as I tried to rationalize why I should just go ahead and release it--that if it does get trashed, I'll just try to learn from my mistakes and do a better job the next time. When I sent it to Disc Makers, I literally closed my eyes as I dropped it in the mailbox.
I'm glad I didn't listen to Mr. Voice of Doubt. Once again, he would have led me down the wrong path.


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Companies of all sizes and within practically every industry have discovered that Google AdWords can considerably boost the visibility of a brand without wreaking havoc on company finances. Since marketing in essence is all about increasing customer or client base in the most cost-efficient manner, Google AdWords is quite a valuable marketing tool.
But like all tools, in order to be truly effective, it must be wielded the proper way; that's where AdWords scripts come in. Carefully constructed AdWords scripts can allow a company to take full advantage of all the features and capabilities of AdWords and thus optimize their profits.
The Benefits of Using AdWords Scripts
AdWords scripts (Google's extensive information on using scripts is located here) provide access to a specific AdWords account through a program called JavaScript. It's important for business marketers to consistently use the most effective AdWords script campaigns available in order to increase campaign performance. Properly executed AdWords scripts can:
- Be automated to run according to a particular time schedule
- Be integrated with external data sources like email, spreadsheets, and URLs
- Send notifications through email when certain parameters are met
- Create detailed and comprehensive performance reports
The above are just a few examples of how AdWords scripts give marketers incredible flexibility within company AdWords accounts. AdWords scripts basically allow businesses to be more active players in their own marketing campaigns.
Bid Headroom: Analyzing Position 1 With AdWords Scripts
Bid headroom is a term that delineates the difference between your maximum and average cost per click. This value is important because the larger the gap between your maximum and average, the less control you will have over your total expenditure.
Using Headroom Analysis to Improve Bidding
The exact bid headroom for an account can be fairly easily calculated — simply subtract the average cost-per-click from bids for keywords where the maximum bids have historically been higher than your CPCs. Marketers can then average out the headroom for position 1 keywords more effectively. By knowing the gap between maximum bid and average CPC, a marketer's PPC budget can be controlled much more effectively.
Unless you want to torture yourself unnecessarily by laboriously attempting to identify these values on your own, the Position 1 Bid Headroom script at the end of this post can be a huge time-saver. This script will make the necessary calculations for you and — like all AdWords scripts — it can be automated to run periodically according to unique account needs. Incorporating a script to identify top position bid headroom can significantly improve control over costs and resolve high cost-per-acquisition issues.
Position 1 Bid Headroom Script as a Solution
For instance, if a company's competitor elects to use an aggressive bidding strategy, this could cause that company's average CPCs to sharply increase. This will set off a cascade of negative effects in your PPC account overall, one of which is an over-inflated cost per acquisition. The position 1 bid headroom AdWords script can help keep the discrepancy between your maximum and average costs in check. The image below shows the location in AdWords where scripts you have available can be uploaded to your AdWords account within the Bulk Operations section of the Campaigns tab.
When set up and managed properly, AdWords campaigns can help businesses grow enormously. By positioning keywords correctly in an AdWords script, ROI goals can be met and profits maximized. Adwords scripts, like the Position 1 Bid Headroom Script below, allow businesses to exert optimal control over their accounts, which in turn maximizes profits.
var spreadsheet_url = "ENTER GOOGLE DOCS SPREADSHEET URL"; var RECIPIENT_EMAIL = "ENTER YOUR EMAIL ADDRESS"; function main() { var maxCPC = 0; var avgCPC = 0; var diff = 0; var row = 0; var spreadsheet = getSpreadsheet(spreadsheet_url); //Get Sheets var sheet = spreadsheet.getActiveSheet(); sheet.clear(); sheet.getRange("A1").setValue("Keyword"); sheet.getRange("B1").setValue("Campaign Name"); sheet.getRange("C1").setValue("AdGroup Name"); sheet.getRange("D1").setValue("Average Position"); sheet.getRange("E1").setValue("Max CPC"); sheet.getRange("F1").setValue("Avg CPC"); sheet.getRange("G1").setValue("Diff %"); var keywordsIterator = AdWordsApp.keywords() .withCondition("AveragePosition < 1.1") .forDateRange("LAST_30_DAYS") .get(); while(keywordsIterator.hasNext()) { var keyword = keywordsIterator.next(); var stats = keyword.getStatsFor("LAST_30_DAYS"); //Modify DateRange as per requirements if(stats.getAveragePosition() == 1 && stats.getAverageCpc() >= 0.05) { row = sheet.getLastRow() + 1; maxCPC = keyword.getMaxCpc(); avgCPC = stats.getAverageCpc(); diff = (maxCPC/avgCPC)*100; sheet.getRange("A" + row).setValue(keyword.getText()); sheet.getRange("B" + row).setValue(keyword.getCampaign().getName()); sheet.getRange("C" + row).setValue(keyword.getAdGroup().getName()); sheet.getRange("D" + row).setValue(stats.getAveragePosition()); sheet.getRange("E" + row).setValue(maxCPC); sheet.getRange("F" + row).setValue(avgCPC); sheet.getRange("G" + row).setValue(diff); } } var newReportLinks = spreadsheet.getUrl(); Logger.log("Report is Ready! Visit the following URL to see it :"); Logger.log(newReportLinks); MailApp.sendEmail( RECIPIENT_EMAIL, 'Report is ready.', newReportLinks); } function getSpreadsheet(spreadsheetUrl) { var matches = new RegExp('key=([^&#]*)').exec(spreadsheetUrl); if (!matches || !matches[1]) { throw 'Invalid spreadsheet URL: ' + spreadsheetUrl; } var spreadsheetId = matches[1]; return SpreadsheetApp.openById(spreadsheetId); }
Image: Keywords Cost — Original Billboard Image from Shutterstock


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Elemental Light National Juried Exhibition
Call Type: Exhibitions
Eligibility: National
City: Cutchogue (North Fork, Long Island)
State: New York
Fee: $40.00
Entry Deadline: 5/15/17
Alex Ferrone Gallery welcomes entries of photographically-based works for the Elemental Light National Juried Exhibition. Juried by Lisa Chalif, Curator of The Heckscher Museum of Art, NY, submissions must depict how the photographic artist uses light in an image. Is light the subject of the image? Is light falling on the subject? Does light separate the subject drastically from the background, etc.? This competition is open to national artists and photographers. Thirty works will be selected for the "Elemental Light Exhibit" in the Gallery from July 8 – July 30, 2017. Juror's Awards include an advertising package, various photographic equipment, fine art prints and framing prizes. Submission fee: $40 for up to three images. Deadline is May 15, 2017.


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Biosensors (EIB) for the Determination of PhycotoxinsFrancesco Botré, PhDDipartimento di Controllo e Gestione Delle Merci del Loro Impatto Sull'Ambiente, Universittá Degli Studi Di Roma, Rome, ItalyThe overall goal of this research program is to develop biosensor-based analytical methods for the analysis of phycotoxins (toxins produced by algae which are responsible, when ingested, of various diseases in man) in mussels. These new methods should at least integrate, but hopefully substitute, the commonly applied "global toxicity tests", i.e. highly invasive bioassays on mammalians (in which the mussel extract is either injected or mixed with the food), which are, at present, the only internationally recognized methods for the screening of these toxins in seafood.
Enzymatic inhibition biosensors (EIBs), being a particular form of response-based analytical devices, would reveal a good compromise between purely "biological" and "physico-chemical" techniques. An EIB represents in fact a sort of "artificial bioindicator", partially combining the flexibility of a biological effect-based test and the selectivity of a physico-chemical assay. In other words, the screening analysis to detect the possible contamination of seafood by phycotoxins would be carried out by "feeding the biosensor" and monitoring the alteration of a specific biochemical parameter, rather than "feeding the mouse" and following the development of generic toxic effects.
The last part of the project is aimed to develop disposable, monoenzymatic biosensors produced by the technique of "screen printing" for the direct determination of algal toxins belonging to the DSP ("diarrhetic shellfish poisoning") group. These novel analytical devices should be used for timely planned monitoring of risky areas and possibly also for shipboard operations.Development and Use of an Immortalized Human Goblet Cell Line for the Use in Ocular Toxicity TestingDarlene Dartt, PhDThe Schepens Eye Research Institute, Harvard University, Boston, MassachusettsThe conjunctival epithelium along with the cornea make up the ocular surface. The conjunctiva has long been used as a component of the Draize test. Mucin secretion from conjunctival tissue has been one of the endpoints measured by this test. The Draize test has been the accepted method by which a variety of agents have been evaluated with respect to their ability to cause irritation and injury to the ocular surface. Unfortunately the inhumane treatment of animals during this test procedure has often been overlooked. To replace the Draize test, many laboratories have used a variety of cell lines and primary cultures of corneal epithelial cells and conjunctival squamous cells. No one, however, has been able to culture conjunctival goblet cells. The long term goal of our proposal is to develop a cell line of human conjunctival goblet cells with an extended life span which will be able to be used for ocular irritancy testing. We hope to accomplish this goal by fulfilling the following specific aims:
The development of a human goblet cell line with an expanded lifespan that secrete mucin and other antibacterial proteins is a useful model that could be potentially use in place of the Draize test.Development of an In Vitro System to Test the Effects and Toxicity of Anti-Inflammatory and Anti-Fibrotic Drugs in the Human LiverGeny Groothuis, PhDUniversity of Groningen, Groningen, The NetherlandsLiver cirrhosis is a fatal liver disease and belongs to the top ten causes of death in the Western World. Cirrhosis is characterized by, among others, excessive deposition of connective tissue (fibrosis) leading to loss of liver function. To date, no adequate drug therapy is available due to the fact that the potential drugs show either lack of effect or serious side effects. The only effective treatment is liver transplantation.
In addition the pathogenesis of the disease process, being the onset and progression of fibrosis and its reversibility, are only partially understood. Research concerning the pathogenesis and the development of drugs is usually performed in animal experiments, which is accompanied by relatively high discomfort for the animals.
In this project an in vitro system using liver slices will be developed in order to be able to investigate the pathogenesis of the disease without treatment of the animals, thereby reducing the number and the discomfort of the animals used. Moreover, the system will allow us to test drugs, developed in our institute for efficacy and toxicity in vitro and in vivo, as is currently the case. In addition, such an in vitro system can be applied to human liver tissue, enabling us to study human specific features of the pathogenesis of liver fibrosis and cirrhosis. This will contribute to a safer first administration of newly developed drugs in man and to a reduction, replacement and refinement of animal experiments.In Vitro Irritancy Test Using Telomerase Transfected Human Corneal CellsJames V. Jester, PhDThe University of Texas Southwestern, Dallas, TexasEye irritation testing is recognized as important in determining the safety of consumer products where manufacture or use may lead to accidental exposure and damage to the eye. Irritancy testing as currently performed, however, requires the use of live animals for which there are no recognized alternative replacement tests. The long-range goal of our work is to first develop and then validate an alternative, replacement test using a human tissue culture model that reconstructs the anterior, exposed portion of the human eye. For the development of a human based tissue culture model we have generated extended-life, telomerase transfected human corneal cells that show growth regulation and differentiation that is similar if not identical to normal human corneal cells. We have also developed a Human Corneal Construct (HCC) using these cells that resembles, in part, normal human corneas. The goal of this research is to evaluate the effectiveness of an HCC Test to predict ocular irritation potential of a wide range of irritants from slight to severe. They will also identify a simple biochemical end point that can be used by other laboratories to determine ocular irritation potential on a standard, commercial basis.Reducing Postoperative Pain and Distress in MiceAlicia Z. Karas, DVMTufts University, Boston, MassachusettsPostoperative pain in laboratory rodents is often not adequately addressed by investigator, for several reasons. One reason for lack of giving pain medications to rodents is the inability to detect overt signs of pain or distress. There is also a genuine lack of knowledge about the administration and effects of pain medications that may lead to their omission from protocols. Although doses of analgesics for rodents are listed in the most current laboratory animal texts, and a few articles have been published regarding suggested techniques, studies to show true efficacy are comparatively rare. There is thus a need to make published information available regarding the presence and extent and treatment of postoperative pain in the mouse.
The weight loss and behavioral data that we have completed thus far tell us that some factor about surgery leads to a serious physiologic/metabolic setback in mice. It may or may not be pain, and main may be one of many contributing factors. We are proposing to study a number of interventions that might improve the welfare of the mouse portoperatively. These interventions will consist of pain medications, fluid and nutrition support, thermal support, and combinations of all interventions. The objective of our work is to use a relatively small number of mice to study techniques and interventions that will reduce postoperative distress. If we are successful, we can make recommendations to investigators and ICES that will not only improve welfare of mice, but theoretically result in less morbidity, and remove a potentially significant source of confounding from studies.Differential Effects of Environmental Enrichment for MiceHal Markowitz, PhD and Clifford Roberts, DVMUniversity of California, San Francisco, CaliforniaPerhaps the most important refinement that can be made in the use of living animals in biomedical research is to improve the ways in which they "model" the disorders for which we seek cures. In this research we evaluate the effect of a number of different daily living conditions and exercise regimen for mice on their behavior and disease progress. Mice that are models for familial Amyotrophic Lateral Sclerosis (ALS) will be assigned to four groups: traditional caging; cages with "mouse houses"; cages with exercise wheels; and a group with wheels in their home cages and individual exercise regimen involving training six days a weeks. Control animals of the same strain will be assigned to identical groups.
Using standardized tasks to evaluate the behavioral abilities of the experimental animals as their disease progresses we will assess the utility of these different living conditions in slowing or accelerating progress of the functional disorder. Examples of these tests, which closely mirror the tests made on human ALS patients, include ability to balance on a rotating rod, gait analysis, and monitoring of food consumption. The control animals will be used to compare these results with normal behavioral change associated with increased age. Differences as a function of caging conditions are not often properly considered and seldom used as a critical component of experimental design. If our results do show differential outcomes we anticipate that methods similar to these will be used increasingly by researchers to refine their use of experimental animals.Genomic Approaches to Defining Pain and Distress in MiceNorman C. Peterson, DVM, PhDJohns Hopkins University, Baltimore, MarylandThis project will utilize micro-chip technology to simultaneously monitor the expression of thousands of genes in mice brains in response to inflammatory pain delivered to a hind paw. By using this technology to develop a "pain stimulus gene expression map", we will be able to better characterize pain perception in mice. Ultimately, this will provide us with a means to more objectively identify conditions that cause pain and distress in laboratory animals, and to develop specific methods/reagents that inhibit or alleviate it in animals and people.Measures to Reduce Stress Caused by Experimental ProceduresBert van Zutphen, PhD and Vera Baumans, DVMUniversity of Utrecht, Utrecht, The NetherlandsAnimals that are used in biomedical research are often submitted to routine experimental procedures. These procedures may cause an imbalance of the animal's homeostasis ('stress'. The purpose of the present project is to measure the animal's stress response to such procedures and to investigate the options for refinement. Is it possible to reduce the stress response through environmental enrichment or through conditioning of the animals? In this study the focus is on injection techniques in mice. It is anticipated that the stress response not only depends on the experimental procedure per se but also on the animal's environmental circumstances (e.g. social housing vs. individual housing; physically enriched housing vs. standard housing) and on the degree of conditioning.
Thus, groups of animals housed under different conditions, will be submitted to routine experimental procedures and the (difference in) stress response will be measured.
In the first year the effects of different kinds of housing conditions will be studied in two mouse inbred strains (BALB/C and C57BL/C). At a later stage the effect of conditioning will be subject of study.
Parameters for measuring the stress response include heart rate, body temperature, activity, food intake, body weight and corticosteroids.
The application of radio-telemetry is needed for stress-free collection of data on heart rate and body temperature. For this purpose a transmitter must be implanted into the abdomen of the animal. Studying the consequences of this procedure is also part of the present project.
Milestones for the first year will be to find answers to the following questions:
Development of an in vitro Cell Model of the Human Blood Brain BarrierSenén Vilaró, PhDSchool of Biology, University of Barcelona, Barcelona, SpainThe main obstacle for efficient drug targeting to the brain lies on the blood-brain barrier (BBB). Separating brain from blood at the level of the endothelial cells from cerebral capillaries, this cell barrier strictly controls the entry of solutes into the central nervous system. To assess the toxicity or bioavailability of drugs in development, academic groups and pharmaceutical companies would benefit from an in vitro model of BBB, based on brain endothelial cells in culture. In response to the need of such in vitro models, the main objective of our proposal is to develop easy-to-use stable immortalized endothelial cell lines from human brain microvessels, which will retain their functional properties and allow to develop an in vitro model of the human BBB as a highly reliable and reproducible alternative method to animal experimentation for pharmacological and toxicological testing of CNS-directed compounds.
Using the isolation procedure developed during the first year of CAAT funding, primary cultures of microvascular endothelial cells will be obtained from total brain samples from post-mortem multidonor patients. As BBB properties are quickly lost in culture, immortalization will be performed on early primary cultures using viral constructs expressing the human telomerase, as immortalizing gene. Selection will be based on expressing the human telomerase, as immortalizing gene. Selection will be based on growth properties and expression of specific brain endothelial markers. Positive immortalized subpopulations will be characterized, in solo or in co-culture with astrocytes, for transendothelial electrical resistance and permeability to standard molecules with known BBB profiles. A correlation will be established between in vitro and in vivo permeability values. Once validated, this in vitro cell model of human BBB will constitute a valuable alternative to animal use for product screening and safety tests. Its application in large high through-put screening will accelerate the CNS-oriented drug discovery, and decrease the R&D costs for pharmaceutical industry.Development of Reversibly Transformed Human Corneal Epithelial Cells as an Optimal In Vitro ModelSteven E. Wilson, MS, MDUniversity of Washington, Seattle, WashingtonMany potential drug and cosmetic products must be tested for ocular toxicities prior to evaluation in humans. In many cases, living animal models are utilized for testing these substances. Since the corneal epithelium is one of the primary tissues that can be injured by drugs or cosmetics, it is our hope that an alternative in vitro testing strategy can be developed that will spare large numbers of experimental animals. Previous investigators have developed corneal epithelial cell lines from animal and humans. However, these previous cell lines have been continually (constuitively) transformed with specific genes such as SV 40 T antigen. Unfortunately, permanent continual expression of those proto-oncogenes results in loss of the normal differentiated state in these epithelial cells.
With the funding from CAAT, we have already developed methods for reversible transformation of human corneal epithelial cells. We have demonstrated that these cells can be induced to proliferate when provided with an inducer triggering expression by the vector, but that the cells assume a more differentiated cell type when the inducer is removed from the culture.
In the last year of the study, it is our intention to utilize a different transforming gene called te lomerase that is present, but closely regulated, in normal human cells and other animal cell types that undergo continuous proliferation. This normal gene is less likely to produce chromosomal abnormality in the epithelial cell lines. We will generate regulatable vectors that express this telomerase gene and insert these into cultured human corneal epithelial cells. We will study normal differentiated functions to select appropriate cell lines that will be of special importance for use in toxicity testing and other applications in which cultured human corneal epithelial cell lines are needed for research.Evaluation of CYP3A Induction with Engineered Cell LinesBingfang Yan, DVM, PhDUniversity of Rhode Island, Kingston, Rhode IslandDrugs entering the human body undergo extensive chemical conversions through an array of diverse catalytic proteins referred to as drug-metabolizing enzymes. Among them, cytochrome P450 (CYP) enzymes rank first among the phase I biotransformation enzymes in terms of catalytic versatility and the number of drugs they metabolize. Approximately twelve CYP enzymes are involved in drug-metabolism with CYP3A enzymes being the most abundant and responsible for the metabolism of two thirds of drugs. CYP3A induction by many drugs is known as an important contributing factor to many failures of therapy or severe toxicity. Recent studies demonstrate that activation of the pregnane X receptor (PXR) is responsible for CYP3A induction by many drugs, providing a rationale for establishing an in vitro screening system. The objective of the proposed studies is to develop a PXR-based in vitro screening system for CYP3A induction. Stable transfectants have been prepared to express steady levels of the PXR and to harbor a PXR responsive reporter. In the final period of support, we will focus on the optimization of the screening conditions such as selection of the best responsive transfectants. Screening of CYP3A inducers has been exclusively dependent upon the use of human hepatocytes and animals. The availability of human livers and the use of a large number of animals are the primary limited factors in rapidly and accurately predicting the effects of drugs on CYP3A expression. The screening system to be established will significantly reduce the number of animal use and ease the supply of human tissues.Bovine Corneal Organ Culture: An Ex Vivo Model for Chemical Toxicity TestsFu-Shin Yu, PhDThe Schepens Eye Research Institute, Boston, MassachusettsFor five decades, the Draize test has remained the accepted method for evaluating the potential of test material to cause eye irritation or injury. Criticisms of this method center on the inhumaned treatment of animals and the irreproducibility of the subjective scoring procedure. There is a great demand for a mechanistic based in vitro testing system that will minimize the use of animals in chemical toxicity tests. Recently, we have developed an ex vivo model for chemical toxicity tests using a simple, long-term corneal organ culture method and tested several chemicals and consumer products. Our results showed that this system that closely resembles an in vivo testing, is an appropriate model for chemical safety tests. The corneas we use are prepared from the bovine eyes, economical and resourceful by-products of meat industry; no live animals are euthanized for testing. To perfect his system, our aims are:
These ex vivo evaluations can be used for accurate prediction of irritation potential in vivo and offer a reliable alternative to the use of live animals.
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Deluded Restaurateur, Bigoted Anti-White Environmentalist & Montel Bong HitsHeadline Potpourri #8
Michael Savage has been dropped from a station in his hometown of San Francisco. As the Bible says, a prophet is without honor in his own land. It is claimed the move was made because the station wanted to go in a different philosophical direction with more contemporary content. In other words, the station managers were actually hoping to propagate leftwing debauchery.
Because they don't want to listen to Glenn Beck, a group of Michigan leftists believes no one else should be allowed to either. From the story, one gets the impression that the group of rabblerousers aren't even members of the Michigan Chamber of Commerce who invited Beck. Does the Chamber of Commerce go and protest whatever leftwing dregs address the socialist conclaves? Did conservatives rampage outside this annual event when serpent man James Carville addressed the event in years past?
Socialistic anti-White bigot Cornel West is scheduled to address a prominent environmentalist conference in Washington. Pluralists will yammer that this organization should have the liberty to invite anyone they want to address their convention. Quite true. However, I am not among these tolerancemongers who are picketing the Michigan Chamber of Commerce for daring to invite Glenn Beck. It must be remembered that, unlike those at 9/12 rallies and Tea Parties, leftists usually destroy property at their protests.
A Maryland restaurateur apparently thinks mass murder is a cutesy laughing matter since he has named his eatery Rhode Island Reds and given it a Bolshevist theme. Does he realize that small business owners like him were lined up against the wall and shot where Communists seized power? If it's O.K. to have an eatery with Communistic decor, maybe we should also open one with a NAZI motif. Better yet, maybe we can have one where patrons are served by waiters wearing Klan robes. Why not? Marxists around the world are guilty of shedding as much and perhaps even more blood than the adherents of fascistic racialism.
If it is improper to shout out during an address before Congress that the President lies, then why is all the incessant fawning applause proper? I ask all of those now in a tizzy, will your manners keep you warm when your freedom has been taken away and you find yourself either in financial ruin at best or in a reeducation camp at worst? If Obama can threaten to call out those critical of his healthcare plan, why can't we do the same to him?
Contrary to his most diehard fanatics, Obama is no God and it is suppose to be the Constitution and not the President that reigns supreme in the land of liberty.
In a display of bipartisanship that would make Nancy Pelosi and President Obama proud, Montel Williams is urging Representative Michelle Bachman to slit her wrists. Is this civil or is Montel held to a different standard because he is a Black liberal? Sounds like someone missed out on their bong hit that morning.
A teen girl claiming to worship Satan set fire to a number of pews inside a California church. However, since the structure was owned by Mormons, a sect ridiculed for being White in terms of its members, it seems authorities are taking a rather blasé approach to the incident. In an account posted at KCRA.com, fire officials said their primary concern is to make sure the girl received counseling rather than to see that she is punished. Had the girl set fire to a Black or Hispanic church, a Jewish synagogue, or an Islamic mosque, would the tone of authorities be so carefree? Had an inexcusable act like this been inflicted upon one of these cherished minorities, California's "Hate Crime" laws would have come into play. After all, the girl's mother has confirmed that the girl hate's the church.
At the local library, there is a map of Central and South America on the wall for immigrants to place a sticker on where they are from. Since suburban Maryland is highly transient in terms of population, where are maps of the other states and countries of the world for the remainder of we taxpayers to do the same? Maybe the library should concentrate on keeping the shelves in order rather than pandering to immigrant populations since as of late they look torn to Hades.
by Frederick Meekins
Frederick Meekins
Issachar Bible Church & Apologetics Research Institute
Send email feedback to Frederick Meekins
Biography - Frederick Meekins
Frederick Meekins is an independent theologian and social critic. He holds a BS in Political Science/History. Frederick earned a MA in Apologetics & Christian Philosophy from Trinity Theological Seminary. Frederick holds a Doctor of Practical Theology through the Master's Graduate School Of Divinity in Evansville, Indiana. Dr. Meekins earned a Ph.D. in Apologetics through Newburgh Theological Seminary. His books are available in print and electronic formats through Amazon.com. His ministry site, Issachar Bible Church & Apologetics Research Institute, can be found at http://issacharbiblechurch.blogspot.com/. The Twitter page of Dr. Meekins can be found at
http://twitter.com/epistolizer .
Visit Frederick Meekins's website at Issachar Bible Church & Apologetics Research Institute
Copyright © 2009 by Frederick MeekinsAll Rights Reserved.
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Learn more about Penlan Pharmaceuticals
ExoCream® is designed to help provide symptomatic relief from common dry skin conditions such as eczema, contact dermatitis and psoriasis. 1
The Primary Care Dermatolgy Society (PCDS) state in their 2015 clinical guidance2:
Emollients are the mainstay of therapy and without them it is not possible to manage eczema effectively. Good evidence shows that the more emollients are used, the less topical steroids are needed. Compliance is essential and so always review patients to check they are happy with what has been prescribed.
Most patients prefer creams and gels. The most important factor is to find one that the patient likes and is happy to use. Ointments tend to be less well tolerated by patients, but they are less likely to cause contact allergic dermatitis as they do not contain preservatives. Encourage appropriate usage by prescribing generous amounts eg 500 grams of moisturisers to use regularly (often QDS).
As with other topical treatments, moisturisers should be gently rubbed into the skin until they are no longer visible. They should be applied downward in the direction of the hairs to lessen the risk of folliculitis.
Warn that they may sting for the first couple of days before soothing the skin
Order of application - if topical steroids are also being used, moisturisers can be applied first and allowed to dry for 15-20 minutes before applying the topical steroid.
Emollients tend to have a short duration of action and will be required to be applied regularly or when needed.
ExoCream® is best applied when the skin is moist and should ideally be applied to the skin at least three or four times a day or as often as recommended by a healthcare professional to keep the skin well moisturised and in good condition. In particular, it is a good idea to regularly apply to the hands because they are exposed to the elements more than any other part of the body.
ExoCream® should be applied liberally to the affected area then smoothed into the skin along the line of hair growth, rather than rubbing it in.
Patients may also want to use ExoCream® after washing their hands, having a bath or taking a shower. Advise patents that when bathing they should use warm not hot water and to avoid staying in the bath too long as this can make dry skin conditions worse.
1ExoCream® Instructions For Use 2016


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2nd Yr Working holiday expires in April. Advice??
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Topic: 2nd Yr Working holiday expires in April. Advice??
Posted: 06/April/2010 at 18:55
Hi Guys/Gals.. My 2nd year working holiday visa is expired on the 22nd of april. On my visa it does not state 'No futher stay'. Im currently in Darwin and had planned to drive to melbourne to be at the birth of my cousins child in June and say goodbye to family as well as stoping off to sight see along the way. Now my question is can apply for a tourist visa inside Australia now or do i have to go home on the 22nd as i will be unable to obtain a tourist Visa. Im from the Uk if that helps.
Thanks all!
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Joined: 02/March/2009
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|Quote Reply Posted: 06/April/2010 at 21:05
Call immigration and advise them what you wish to do and ask is there any visa you can obtain for further stay.
Do not overstay as this will cost you a lot of money and seriously disadvantage you if you ever wish to come back.
I am NOT a lawyer. Anything said is NOT legal advice.
Please post your legal questions in a forum rather than sending a PM. Thanks.
Joined: 06/April/2010
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|Quote Reply Posted: 06/April/2010 at 21:37
Thanks buddy. No i do not intend to overstay. Ive got to many friends and family over here to risk not being allowed back in at any stage!
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E is for Epona
This month is the A to Z Blog Challenge and I've chosen to cover the topic of deities. I'll post a deity from religions across the world, past and present. Many of these inspire the gods within the books I write. I find the topic fascinating and hope you enjoy each post this month.
E is for Epona
Celtic Horse Goddess associated with fertility, a cornucopia, horses, mules and oxen
who accompanied it's soul on its final journey.
This goddess is unique as she was adopted by the Romans and a temple was erected to her in Rome.
~Sabrina A. Fish is the author of YA Fantasy novellas Lost Haven, Road to Nowhere, and The Gilded Cage. You can follow here or go to her website to learn more about her books.


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